PMID- 10151618 OWN - NLM STAT- MEDLINE DCOM- 19951205 LR - 20220408 IS - 0963-8172 (Print) IS - 0963-8172 (Linking) VI - 4 IP - 2 DP - 1995 Jun TI - Understanding adverse events: human factors. PG - 80-9 AB - (1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole. FAU - Reason, J AU - Reason J AD - Department of Psychology, University of Manchester, UK. LA - eng PT - Journal Article PL - England TA - Qual Health Care JT - Quality in health care : QHC JID - 9209948 MH - Accidents, Occupational/*prevention & control/psychology MH - Automation MH - Behavior MH - England MH - Health Personnel/*psychology MH - Health Services Research MH - Humans MH - Iatrogenic Disease/*prevention & control MH - Patient Care Team/standards MH - Psychology, Industrial MH - Risk Management/*standards PMC - PMC1055294 EDAT- 1995/05/08 00:00 MHDA- 1995/05/08 00:01 PMCR- 1995/06/01 CRDT- 1995/05/08 00:00 PHST- 1995/05/08 00:00 [pubmed] PHST- 1995/05/08 00:01 [medline] PHST- 1995/05/08 00:00 [entrez] PHST- 1995/06/01 00:00 [pmc-release] AID - 10.1136/qshc.4.2.80 [doi] PST - ppublish SO - Qual Health Care. 1995 Jun;4(2):80-9. doi: 10.1136/qshc.4.2.80. 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Welters P128 - Validity of the age-adjusted d-dimer cutoff in patients with COPD B. Bombay, J. M. Chauny, R. D. Daoust, J. L. Lessard, M. M. Marquis, J. P. Paquet P129 - A scoping review of strategies for prevention and management of bleeding following paediatric cardiopulmonary bypass surgery K. Siemens, D. Sangaran, B. J. Hunt, A. Durward, A. Nyman, I. A. Murdoch, S. M. Tibby P130 - Nadir hemoglobulin during cardiopulmonary bypass: impact on postoperative morbidity and mortality F. Ampatzidou, D. Moisidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, G. Drossos P131 - Red blood cell transfusion do not influence the prognostic value of RDW in critically ill patients S. Spadaro, A. Fogagnolo, T. Fiore, A. Schiavi, V. Fontana, F. Taccone, C. Volta P132 - Reasons for admission in the paediatric intensive care unit and the need for blood and blood products transfusions E. Chochliourou, E. Volakli, A. Violaki, E. Samkinidou, G. Evlavis, V. Panagiotidou, M. Sdougka P133 - The implementation of a massive haemorrhage protocol (mhp) for the management of major trauma: a ten year, single-centre study R. Mothukuri, C. Battle, K. Guy, G. Mills, P. Evans P134 - An integrated major haemorrhage protocol for pre-hospital and retrieval medical teams J. Wijesuriya, S. Keogh P135 - The impact of transfusion thresholds on mortality and cardiovascular events in patients with cardiovascular disease (non-cardiac surgery): a systematic review and meta-analysis A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth P136 - The relationship between poor pre-operative immune status and outcome from cardiac surgery is specific to the peri-operative antigenic threat S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies P137 - Impact of simple clinical practice guidelines for reducing post-operative atrial fibrillation after cardiac surgery. A. Omar, M. Allam, O. Bilala, A. Kindawi, H. Ewila P138 - Dexamethasone administration during cardiopulmonary bypass has no beneficial effects on elective postoperative cardiac surgery patients F. Ampatzidou, D. Moisidou, M. Nastou, E. Dalampini, A. Malamas, E. Vasilarou, G. Drossos P139 - Intra-aortic balloon counterpulsation in patients undergoing cardiac surgery (IABCS): preliminary results G. Ferreira, J. Caldas, J. Fukushima, E. A. Osawa, E. Arita, L. Camara, S. Zeferino, J. Jardim, F. Gaioto, L. Dallan, F. B. Jatene, R. Kalil Filho, .F Galas, L. A. Hajjar P140 - Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury C. Mitaka, T. Ohnuma, T. Murayama, F. Kunimoto, M. Nagashima, T. Takei, M. Tomita P141 - Acute kidney injury influence on high sensitive troponin measurements after cardiac surgery A. Omar, K. Mahmoud, S. Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi P142 - Complex evaluation of endothelial dysfunction markers for prognosis of outcomes in patients undergoing cardiac surgery I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov P143 - New-onset atrial fibrillation in intensive care: incidence, management and outcome S. A. Jenkins, R. Griffin P144 - One single spot measurement of the sublingual microcirculation during acute pulmonary hypertension in a pig model of shock M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince P145 - Assessment of levosimendan as a therapeutic option to recruit the microcirculation in cardiogenic shock – initial experience in cardiac ICU A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon P146 - Terlipressin vs. norepinephrine in the Potential Multiorgan Donor(PMD) F. Righetti, E. Colombaroli, G. Castellano P147 - Echocardiography in the potential heart donor exposed to substitution hormonotherapy F. Righetti, E. Colombaroli P148 - Machine learning can reduce rate of monitor alarms M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky P149 - Peripherally inserted central catheters placed in the ICU S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon P150 - Recordings of abnormal central venous pressure waveform morphology during an episode of pulmonary hypertension in a porcine shock model M. S. Tovar Doncel, C. Ince, C. Aldecoa, A. Lima P151 - Ultrasound guided central venous access technique among French intensivists M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel P152 - Predictive ability of the Pv-aCO2 gap in patients with shock M. Shaban, R. Kolko, N. Salahuddin, M. Sharshir, M. AbuRageila, A. AlHussain P153 - Comparison of echocardiography and pulmonary artery catheter measurements of hemodynamic parameters in critical ill patients P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama P154 - The volume clamp method for noninvasive cardiac output measurement in postoperative cardiothoracic surgery patients: a comparison with intermittent pulmonary artery thermodilution J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel P155 - Hemodynamic monitoring in patients with septic shock (SS) – CPCCO (continuous pulse contour cardiac output) vs. TEE (transesophageal echocardiography) E. Colombaroli, F. Righetti, G. Castellano P156 - Cardiac output measurement with transthoracic echocardiography in critically ill patients: a pragmatic clinical study T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos P157 - Left ventricular outflow tract velocity time integral correlates with stroke volume index in mechanically ventilated patients Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana P158 - Transpulmonary thermodilution (TPTD) derived from femoral vs. jugular central venous catheter: validation of a previously published correction formula and a proprietary correction formula for global end-diastolic volume index (GEDVI) W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P159 - Venous return driving pressure and resistance in acute blood volume changes P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger P160 - Dynamic arterial elastance calculated with lidcoplus monitor does not predict changes in arterial pressure after a fluid challenge in postsurgical patients D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi P161 - Analysis of duration of post-operative goal-directed therapy protocol C. Ostrowska, H. Aya, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, A. Rhodes, M. Cecconi P162 - Hemodynamic optimization – back to square one? M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm P163 - Effectiveness of fluid thoracic content measurement by bioimpedance guiding intravascular volume optimization in patients with septic shock M. Aguilar Arzapalo, L. Barradas, V. Lopez, M. Cetina P164 - A systematic review on the role of internal jugular vein ultrasound measurements in assessment of volume status in critical shock patients N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani P165 - Importance of recognizing dehydration in medical Intensive Care Unit M. Mackovic, N. Maric, M. Bakula P166 - Effect of volume for a fluid challenge in septic patients H. Aya, A. Rhodes, R. M. Grounds, N. Fletcher, M. Cecconi P167 - Fluid bolus practices in a large Australian intensive care unit B. Avard, P. Zhang P168 - Liberal late fluid management is associated with longer ventilation duration and worst outcome in severe trauma patients: a retrospective cohort of 294 patients M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila P169 - Association of fluids and outcomes in emergency department patients hospitalized with community-acquired pneumonia P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro P170 - Association of positive fluid balance with poor outcome in medicosurgical ICU patients A. Ben Souissi, I. Mezghani, Y. Ben Aicha, S. Kamoun, B. Laribi, B. Jeribi, A. Riahi, M. S. Mebazaa P171 - Impact of fluid balance to organ dysfunction in critically ill patients C. Pereira, R. Marinho, R. Antunes, A. Marinho P172 - Volume bolus in ICU patients: do we need to balance our crystalloids? M. Crivits, M. Raes, J. Decruyenaere, E. Hoste P173 - The use of 6 % HES solution do not reduce total fluid requirement in the therapy of patients with burn shock V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein P174 - Electron microscopic assessment of acute kidney injury in septic sheep resuscitated with crystalloids or different colloids T. Kampmeier , P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer P175 - Alterations of conjunctival microcirculation in a sheep model of haemorrhagic shock and resuscitation with 0.9 % saline or balanced tetrastarch P. Arnemann, M. Hessler, T. Kampmeier, S. Rehberg, H. Van Aken, C. Ince, C. Ertmer P176 - A single centre nested pilot study investigating the effect of using 0.9 % saline or Plasma-Lyte 148 ® as crystalloid fluid therapy on gastrointestinal feeding intolerance in mechanically ventilated patients receiving nasogastric enteral nutrition S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young P177 - A single centre nested pilot study investigating the effect on post-operative bleeding of using 0.9 % saline or Plasma-Lyte® 148 as crystalloid fluid therapy in adults in ICU after heart surgery S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, P. Young P178 - Extreme hypernatremia and sepsis in a patient with Huntington’s dementia: a conundrum in fluid management H. Venkatesh, S. Ramachandran, A. Basu, H. Nair P179 - Diagnosis and management of severe hypernatraemia in the critical care setting S. Egan, J. Bates P180 - Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients S. Oliveira, N. R. Rangel Neto, F. Q. Reis P181 - Missing the “I” in MUDPILES – a rare cause of high anion gap metabolic acidosis (HAGMA) C. P. Lee, X. L. Lin, C. Choong , K. M. Eu, W. Y. Sim , K. S. Tee, J. Pau , J. Abisheganaden P182 - Plasma NGAL and urinary output: potential parameters for early initiation of renal replacement therapy K. Maas, H. De Geus P183 - Renal replacement therapy for critically ill patients: an intermittent continuity E. Lafuente, R. Marinho, J. Moura, R. Antunes, A. Marinho P184 - A survey of practices related to renal replacement therapy in critically ill patients in the north of England. T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez P185 - High initiation creatinine associated with lower 28-day mortality in critically ill patients necessitating continuous renal replacement therapy S. Stads, A. J. Groeneveld P186 - The impact of Karnofsky performance scale on outcomes in acute kidney injury patients receiving renal replacement therapy on the intensive care unit I. Elsayed, N. Ward, A. Tridente, A. Raithatha P187 - Severe hypophosphatemia during citrate-anticoagulated CRRT A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles P188 - Citrate regional anticoagulation for post dilution continuous renal replacement therapy S. Ghabina P189 - Citrate 18 mmol/l improves anticoagulation during RRT with adsorbing filters F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco P190 - Calcium gluconate instead of calcium chloride in citrate-anticoagulated CVVHD O. Demirkiran, M. Kosuk, S. Bozbay P191 - Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis (CVVHD) using Ultraflux EMiC2 vs. Ultraflux AV1000S V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann P192 - Removal of bilirubin with a new adsorbent system: in vitro kinetics S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti P193 - Case series of patients with severe sepsis and septic shock treated with a new extracorporeal sorbent T. Laddomada, A. Doronzio, B. Balicco P194 - In vitro adsorption of a broad spectrum of inflammatory mediators with CytoSorb® hemoadsorbent polymer beads M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan P195 - Observations in early vs. late use of cytosorb therapy in critically ill patients K. Kogelmann, M. Drüner, D. Jarczak P196 - Oxiris membrane decreases endotoxin during rrt in septic patients with basal EAA > 0,6 F. Turani, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, R. Barchetta P197 - An observational prospective study on the onset of augmented renal clearance: the first report S. Morimoto, H. Ishikura P198 - An ultrasound- guided algorithm for the management of oliguria in severe sepsis I. Hussain, N. Salahuddin, A. Nadeem, K. Ghorab, K. Maghrabi P199 - Ultrasound in acute kidney injury (aki). First findings of farius, an education-programme in structural ultrasonography S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies P200 - Effectiveness of renal angina index score predicting acute kidney injury on critically ill patients M. Aguilar Arzapalo, L. Barradas, V. Lopez, A. Escalante, G. Jimmy, M. Cetina P201 - Time length below blood pressure thresholds and progression of acute kidney injury in critically ill patients with or without sepsis: a retrospective, exploratory cohort study J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura P202 - Anaemia does not affect renal recovery in acute kidney injury J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann P203 - Estimated glomerular filtration rate based on serum creatinine: actual practice in Dutch ICU’s A. Hana, H. R. De Geus P204 - Comparison of estimated glomerular filtration rate calculated by mdrd, ckd-epi-serum-creatinine and ckd-epi-cystatin-c in adult critically ill patients H. R. De Geus, A. Hana P205 - Early diagnosis of septic acute kidney injury in medical critical care patients with a urine cell cycle arrest marker: insulin like growth factor binding protein-7 (IGFBP-7) M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri P206 - Urinary neutrophil gelatinase-associated lipocalin as early biomarker of severe acute kidney injury in intensive care J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper P207 - Shrunken pore syndrome is associated with a sharp rise in mortality in patients undergoing elective coronary artery bypass grafting A. Dardashti, A. Grubb P208 - The biomarker nephrocheck™ can discriminate the septic shock patients with an akin 1 or 2 acute renal failure who will not progress toward the akin 3 level J. Maizel, M. Wetzstein, D. Titeca, L. Kontar, F. Brazier, B. De Cagny, A. Riviere, T. Soupison, M. Joris, M. Slama P209 - A worldwide multicentre evaluation of acute kidney injury in septic and non-septic critically ill patients: the intensive care over nations (icon) audit E. Peters, H. Njimi, P. Pickkers, J. L. Vincent P210 - Does enhanced recovery after surgery reduce the incidence of acute kidney injury in those undergoing major gynae-oncological surgery? M. Waraich , J. Doyle, T. Samuels, L. Forni P211 - Identification of risk factors for the development of acute kidney injury after lower limb arthroplasty N. Desai, R. Baumber, P. Gunning, A. Sell P212 - Incidences and associations of acute kidney injury after major trauma S. Lin, H. Torrence, M. O’Dwyer, C. Kirwan, J. Prowle P213 - Acute kidney injury of major trauma patients T Kim P214 - Trajectory of serum creatinine after major surgery and the diagnosis of acute kidney injury M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle P215 - Epidemiology of acute kidney injury after cardiac surgery. A single center retrospective study S. Hanoura , A. Omar, H. Othamn, S. Sudarsanan , M. Allam, M. Maksoud, R. Singh, A. Al Khulaifi P216 - Post-operative acute kidney injury after major non-cardiac surgery and its association with death in the following year M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, J. Prowle P217 - Factors affecting acute renal failure in intensive care unit and effect of these factors on mortality O. Uzundere, D. Memis , M. Ýnal, A. , N. Turan P218 - Results of the live kidney transplantations according to national data of turkish organ and tissue information system M. A. Aydin, H. Basar, I. Sencan, A. Kapuagasi, M. Ozturk, Z. Uzundurukan, D. Gokmen, A. Ozcan, C. Kaymak P219 - Anaesthesia procedure and intensive therapy in patients with neck phlegmon V. A. Artemenko, A. Budnyuk P220 - Nasal high flow oygen for acute respiratory failure: a systematic review R. Pugh , S. Bhandari P221 - Setting optimal flow rate during high flow nasal cannula support: preliminary results T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti P222 - Dose to dose consistency across two different gas flow rates using cystic fibrosis and normal adult breathing profiles during nasal high flow oxygen therapy L. Sweeney, A . O’ Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin P223 - Final results of an evaluation of airway medix closed suction system compared to a standard closed suction system M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi P224 - Different cuff materials and different leak tests - one size does not fit all T. Poropat, R. Knafelj P225 - Observational study on the value of the cuff-leak test and the onset of upper airway obstruction after extubation E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas P226 - A device for emergency transtracheal lung ventilation D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider P227 - Long-term outcome and health-related quality of life in patients discharged from the intensive care unit with a tracheostomy and with or without prolonged mechanical ventilation S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, J. Decruyenaere P228 - Ultrasound-guided percutaneous dilational tracheostomy versus bronchoscopy-guided percutaneous dilational tracheostomy in critically ill patients (trachus): a randomized clinical trial A. Gobatto, B. Bese, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson P229 - Is it safe to discharge patients with tracheostomy from the ICU to the ward? B. C. Civanto, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia P230 - The application of tracheostomy in children in ICU A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu P231 - The impact of passive humidifiers on aerosol drug delivery during mechanical ventilation P. Kelly, A. O’Sullivan, L. Sweeney, R. MacLoughlin P232 - Evaluation of vibrating mesh and jet nebuliser performance at two different attachment setups in line with a humidifier nebuliser system A. O’Sullivan, P. Kelly, L. Sweeney, E. Mukeria, M. Wolny , R. MacLoughlin P233 - Psv-niv versus cpap in the treatment of acute cardiogenic pulmonary edema A. Pagano, F. Numis, G. Vison, L. Saldamarco, T. Russo, G. Porta, F. Paladino P234 - Noninvasive ventilation in patients with haematologic malignancy: a retrospective review C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta P235 - Use of non-invasive ventilation in infectious diseases besides classical indications A. Silva-Pinto, A. Sarmento, L. Santos P236 - The impact of fragility on noninvasive mechanical ventilation application and results in the ICU Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, M. Aydogdu, G. Aygencel, Z. Ülger, G. Gursel P237 - Effects of metabolic alkalosis on noninvasive ventilation success and ICU outcome in patients with hypercapnic respiratory failure N. Boyacý, Z. Isýkdogan, Ö. Özdedeoglu, Z. Güllü, M. Badoglu, U. Gaygýsýz, M. Aydogdu, G. Gursel P238 - Asynchrony index and breathing patterns of acute exacerbation copd patients assisted with noninvasive pressure support ventilation and neurally adjusted ventilatory assist N. Kongpolprom, C. Sittipunt P239 - High frequency jet ventilation for severe acute hypoxemia A. Eden, Y. Kokhanovsky, S. Bursztein – De Myttenaere, R. Pizov P240 - HFOV revisited: a 7 year retrospective analysis of patients receiving HFOV who met oscillate trial entry criteria L. Neilans, N. MacIntyre P241 - Implementation of a goal-directed mechanical ventilation order set driven by respiratory therapists can improve compliance with best practices for mechanical ventilation M. Radosevich, B. Wanta, V. Weber, T. Meyer, N. Smischney, D. Brown, D. Diedrich P242 - A reduction in tidal volumes for ventilated patients on ICU calculated from IBW. can it minimise mortality in comparison to traditional strategies? A . Fuller, P. McLindon, K. Sim P243 - Predictive value of lung aeration scoring using lung ultrasound in weaning failure M. Shoaeir, K. Noeam, A. Mahrous, R. Matsa, A. Ali P244 - Conventional versus automated weaning from mechanical ventilation using SmartCare™ C. Dridi, S. Koubaji, S. Kamoun, F. Haddad, A. Ben Souissi, B. Laribi, A. Riahi, M. S. Mebazaa P245 - Ultrasonographic evaluation protocol for weaning from mechanichal ventilation A. Pérez-Calatayud, R. Carrillo-Esper, A. Zepeda-Mendoza, M. Diaz-Carrillo, E. Arch-Tirado P246 - Diaphragm ultrasonography: a method for weaning patients from mechanical ventilation S. Carbognin, L. Pelacani, F. Zannoni, A. Agnoli, G. Gagliardi P247 - Dorsal diaphragmatic excursion tracks transpulmonary pressure in ventilated ARDS patients: a potential non-invasive indicator of lung recruitment? R. Cho, A. Adams , S. Lunos, S. Ambur, R. Shapiro, M. Prekker P248 - Pulse oximetry in the icu patient: is the perfusion index of any value? M. Thijssen, L. Janssen, N. Foudraine P249 - Ventilation is a better assessment of respiratory status than EtCO2 C. J. Voscopoulos, J. Freeman P250 - Evaluation of the relationship between non-invasive minute ventilation and end-tidal CO2 in patients undergoing general vs spinal anesthesia C. J. Voscopoulos, J. Freeman, E. George P251 - Respiratory volume monitoring provides early warning of respiratory depression and can be used to reduce false alarms in non-intubated patients C. J. Voscopoulos, D. Eversole, J. Freeman, E. George P252 - P/i index: a predictive edi-derived weaning index during nava S. Muttini, R. Bigi, G. Villani, N. Patroniti P253 - Adequacy of ventilation in patients receiving opioids in the post anesthesia care unit: minute ventilation versus respiratory rate G. Williams, C. J. Voscopoulos, J. Freeman, E. George P254 - Comparison of regional and global expiratory time constants measured by electrical impedance tomography (EIT) A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis P255 - Electrical impedance tomography: robustness of a new pixel wise regional expiratory time constant calculation A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis P256 - Validation of regional and global expiratory time constant measurement by electrical impedance tomography in ards and obstructive pulmonary diseases C. K. Karagiannidis, A. W. Waldmann, S. B. Böhm, S. Strassmann, W. W. Windisch P257 - Transpulmonary pressure in a model with elastic recoiling lung and expanding chest wall P. Persson, S. Lundin, O. Stenqvist P258 - Lactate in pleural and abdominal effusion G. Porta, F. Numis, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero P259 - Outcome of patients admitted to the intensive care with pulmonary fibrosis F. Asota, K. O’Rourke, S. Ranjan, P. Morgan P260 - Sedation and analgesia practice in extra-corporeal membrane oxygenation (ECMO)-treated patients with acute respiratory distress syndrome (ARDS): a retrospective study J. W. DeBacker, E. Tamberg, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Mehta P261 - Characteristics and outcomes of patients deemed not eligible when referred for veno-venous extracorporeal membrane oxygenation (vv-ECMO) S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke P262 - The SAVE SMR for veno-arterial ECMO R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger P263 - A simplified score to predict early (48 h) mortality in patients being considered for VA-ECMO A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge P264 - Lung function six months post extra corporeal membrane oxygenation (ECMO) for severe acute respiratory failure in adult survivors C. Sampson, S. Harris-Fox P265 - Bicarbonate dialysis removes carbon dioxide in hypoventilated rodents. M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum P266 - Procalcitonin as predictor of primary graft dysfunction and mortality in post-lung transplantation C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello P267 - New molecular biomarkers of acute respiratory distress syndrome in abdominal sepsis A. K. Kuzovlev, V. Moroz, A. Goloubev, S. Polovnikov, S. Nenchuk P268 - Tight junction’s proteins claudin -5 and regulation by tnf in experimental murine lung injury model of ali/ards V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos P269 - Cell counts in endobronchial aspirate to assess airway inflammation in ARDS patients: a pilot study S. Spadaro, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, C. Volta P270 - Epidemiological and clinical profile of patients with acute respiratory distress syndrome in the surgical intensive care unit surgical, hospital JRA, Antananarivo T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera P271 - Effect of high PEEP after recruitment maneuver on right ventricular function in ARDS. Is it good for the lung and for the heart? S. El-Dash, ELV Costa, MR Tucci, F Leleu, L Kontar, B. De Cagny, F. Brazier, D. Titeca, G. Bacari-Risal, J. Maizel, M. Amato, M. Slama P272 - Effect of recruitment maneuver on left ventricular systolic strain P. Mercado, J. Maizel, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, S. El Dash, M. Slama P273 - Inhaled nitric oxide – is switching supplier cost effective? Remmington, A. Fischer, S. Squire, M. Boichat P274 - Epidemiological study of severe acute pancreatitis in Japan, comparison of the etiology and the patient outcomes on 1159 patients. H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui P275 - Extracorporeal liver support therapy. Experience in an intensive care unit R. Marinho, J. Daniel, H. Miranda, A. Marinho P276 - Accuracy of mortality prediction models in acute versus acute-on-chronic liver failure in the intensive care setting K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters P277 - Risk of coronary artery disease in patients with chronic liver disease: a population based cohort study Y. Su P278 - 20 years of liver transplantation in Santiago de Compostela (Spain). Experience review J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez P279 - Diarrhea is a risk factor for liver injury and may lead to intestinal failure associated liver disease in critical illness N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll P280 - Bowel care on the intensive care unit: constipation guideline compliance and complications K. Tizard, C. Lister, L. Poole P281 - Malnutrition assessed by phase angle determines outcomes in low risk cardiac surgery patients D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite P282 - Preoperative fasting times in an irish hospital A. O’Loughlin, V. Maraj, J. Dowling P283 - Costs and final outcome of early x delayed feeding in a private Brazil ICU M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes P284 - Can ventilator derived energy expenditure measurements replace indirect calorimetry? T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard P285 - Revisiting the refeeding syndrome: results of a systematic review N. Friedli, Z. Stanga, B. Mueller, P. Schuetz P286 - Compliance with the new protocol for parenteral nutrition in our ICU L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois P287 - Nutrition may be another treatment in the intensive care unit where less is more? R. Marinho, H. Castro, J. Moura, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, A. Marinho P288 - Should we provide more protein to critically ill patients? R. Marinho, M. Santos, E. Lafuente, H. Castro, S. Cabral, J. Moura, P. Martins, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, P. Casteloes, A. Marinho P289 Protein provision in an adult intensive care unit S. Gray P290 - Prevalence and clinical outcomes of vitamin d deficiency in the medical critically ill patients in Songklanagarind hospital K. Maipang, R. Bhurayanontachai P291 - Vitamin d deficiency strongly predicts adverse medical outcome across different medical inpatient populations: results from a prospective study L. G. Grädel, P. Schütz P292 - Omega-3 fatty acids in patients undergoing cardiac surgery: a systematic review and meta-analysis P. Langlois, W. Manzanares P293 - Can 5-hydroxytriptophan prevent post-traumatic stress disorder in critically ill patients? R. Tincu, C. Cobilinschi, D. Tomescu, Z. Ghiorghiu, R. Macovei P294 - Parenteral selenium in the critically ill: an updated systematic review and meta-analysis W. Manzanares, P. Langlois, M. Lemieux, G. Elke, F. Bloos, K. Reinhart, D. Heyland P295 - Probiotics in the critically ill: an updated systematic review and meta-analysis P. Langlois, M. Lemieux, I. Aramendi, D. Heyland, W. Manzanares P296 - Diabetes with hyperglycemic crisis episodes may be associated with higher risk of pancreatic cancer: a population-based cohort study Y. 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Koutsogiannidis, M. Moschopoulou, G. Drossos P302 - Lactate levels in diabetic ketoacidosis patients at ICU admissions G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel P303 - Intensive care implications of merging heart attack centre units in London J. M. Wong, C. Fitton, S. Anwar, S. Stacey P304 - Special characteristics of in-hospital cardiac arrests M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis P305 - Clinical evaluation of ICU-admitted patients who were resuscitated in the general medicine ward S. Suda , T. Ikeda, S. Ono, T. Ueno, Y. Izutani P306 - Serious game evaluation of a one-hour training basic life support session for secondary school students: new tools for future bystanders S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon P307 - Public and clinical staff perceptions and knowledge of CPR compared to local and national data J. C White, A. Molokhia, A. 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Perkins P335 Timing of endovascular and surgical treatment for aneurysmal subarachnoid haemorrhage: early but not so fast. J. Rubio, J. A. Rubio, R. Sierra P336 Red blood cell transfusion in aneurysmal subarachnoid hemorrhage – the Sahara cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre P337 - Aneurysmal subarachnoid hemorrhage and anemia: a canadian multi-centre retrospective cohort study S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. 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Suchomel P343 - Evaluation of levetiracetam pharmacokinetics after severe traumatic brain injury in neurocritical care patients at a level one trauma center N. Ebert, J. Jancik, H. Rhodes P344 - Model based time series cluster analysis to determine unique patient states in traumatic brain injury T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella P345 - Brain compartment monitoring capabilities from ICP to BI (bioimpedance) during HS (hypertonic saline) administration. State of art simulation outcome depending on brain swelling type A. K. Kink , I. R. Rätsep P346 - Transfusion of red blood cells in patients with traumatic brain injury admitted to Canadian trauma health centers: a multicenter cohort study A. Boutin, L. Moore, M. Chasse, R. Zarychanski, F. Lauzier, S. English, L. McIntyre, J. Lacroix, D. Griesdale, P. Lessard-Bonaventure, A. F. 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Schuetz P351 - Developing an innovative emergency medicine point-of-care simulation programme T. Brown, J. Collinson, C. Pritchett, T. Slade P352 - The InSim program: an in situ simulation program for junior trainees in intensive care M. Le Guen, S. Hellings, R. Ramsaran P353 - Impact of excessive and inappropriate troponin testing in the emergency setting how good are we A. Alsheikhly P354 - The development of time tracking monitor at emergency department T. Abe P355 - Role of focussed echocardiography in emergency assessment of syncope L. Kanapeckaite, M. Abu-Habsa, R. Bahl P356 - Insertion of an open-ended 14-gauge catheter through the chest wall causes a significant pneumothorax in a self-ventilating swine model M. Q Russell, K. J. Real, M. Abu-Habsa , R. M. Lyon, N. P. Oveland P357 - Ez-io® intraosseous access teaching in the workplace using a mobile ‘tea trolley’ training method J. Penketh, M. Mcdonald, F. 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Hines P396 - Identifying poor outcome patient groups in a resource-constrained critical care unit K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy P397 - Effects of icu weekend admission and discharge on mortality. E. Moreira, F. Verga, M. Barbato, G. Burghi P398 - Organizational factors, outcomes and resource use in 9,946 cancer patients admitted to 70 ICUs M Soares, U. V. Silva, L. C. Azevedo, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, P. E. Brasil, F. A. Bozza, J. I. Salluh P399 - Evaluation of oncological critically ill patients, severity score and outcome compared to not oncological in a particular hospital cti. M. B. Velasco, D. M. Dalcomune P400 - Outcomes of patients admitted to a large uk critical care department with palliative oncological diagnoses R. Marshall, T. Gilpin, A. Tridente, A. Raithatha P401 - Predictors of mortality in febrile neutropenic patients with haematological malignancies admitted to an intensive care unit of a cancer center D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria P402 - Patients with hematologic malignancies requiring invasive mechanical ventilation: characteristics and predictors of mortality H. Al-Dorzi, H. Al Orainni , F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, Y. Arabi P403 - Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review S. Gaudry, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, D. Dreyfuss, F. Tubach P404 - Alopecia in survivors of critical illness: a qualitative study C . Battle, K. James, P. Temblett P405 - The impact of mental health on icu admission L. Davies, C. Battle, C. Lynch P406 - Cognitive impairment 5 years after ICU discharge S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso P407 - Apache ii versus apache iv for octagenerians in medical icu M. Fister, R. Knafelj P408 - Outcomes of octagenarians in an indian icu P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran P409 - Mortality and outcomes in elderly patients 80 years of age or older admitted to the icu M. B. Velasco , D. M. Dalcomune P410 - Octagenerians in medical icu - adding days to life or life to days? R. Knafelj, M. Fister P411 - The very elderly admitted to intensive care unit: outcomes and economic evaluation N. Chin-Yee, G. D’Egidio, K. Thavorn, D. Heyland, K. Kyeremanteng P412 - The very elderly in intensive care: relationship between acuity of illness and long-term mortality A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott P413 - Acquired weakness in an oncological intensive care unit I. Guerreiro P414 - Musculoskeletal problems in intensive care unit (ICU) patients post-discharge H. Devine, P. MacTavish, J. McPeake, T. Quasim, J. Kinsella, M. Daniel P415 - Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness C. Goossens M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche P416 - Physical outcome measures for critical care patients following intensive care unit (icu) discharge H. Devine, P. MacTavish, T. Quasim, J. Kinsella, M. Daniel, J. McPeake P417 - Improving active mobilisation in a general intensive care unit B. Miles , S. Madden, H. Devine P418 - Mobilization in patients on vasoactive drugs use – a pilot study. M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade P419 - Pharmacy intervention at an intensive care rehabilitation clinic P. MacTavish, J. McPeake, H. Devine, J. Kinsella, M. Daniel, R. Kishore, C. Fenlon, T. Quasim P420 - Interactive gaming is feasible and potentially increases icu patients’ motivation to be engaged in rehabilitation programs T. Fiks, A. Ruijter, M. Te Raa, P. Spronk P421 - Simulation-based design of a robust stopping rule to ensure patient safety Y. S. Chiew, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, C. Pretty, G. M. Shaw, J. G. Chase P422 - Are daily blood tests on the intensive care unit necessary? T. Hall, W. C. Ngu, J. M. Jack, P. Morgan P423 - Measuring urine output in ward patients: is it helpful? B. Avard, A. Pavli, X. Gee P424 - The incidence of pressure ulcers in an adult mixed intensive care unit in turkey C . Bor, E. Akin Korhan, K. Demirag, M. Uyar P425 - Intensivist/patient ratios in closed ICUs in Alexandria, Egypt; an overview M. Shirazy, A. Fayed P426 - Eicu (electronic intensive care unit): impact on ALOS (average length of stay) in a developing country like India S. Gupta, A. Kaushal, S. Dewan, A. Varma P427 - Predicting deterioration in general ward using early deterioration indicator E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson P428 - High impact enhanced critical care outreach - the imobile service: making a difference E. Helme, R. Broderick, S. Hadfield, R. Loveridge P429 - Impact of bed availability and cognitive load on intensive care unit (ICU) bed allocation: a vignette-based trial J. Ramos, D. Forte P430 - Characteristics of critically ill patients admitted through the emergency department F. Yang, P. Hou P431 - Admission to critical care: the quantification of functional reserve J. Dudziak, J. Feeney, K. Wilkinson, K. Bauchmuller, K. Shuker, M. Faulds, A. Raithatha, D. Bryden, L. England, N. Bolton, A. Tridente P432 - Admission to critical care: the importance of frailty K. Bauchmuller, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Research Collaboration P433 - Development of an instrument to aid triage decisions for intensive care unit admission J. Ramos, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I . Velasco, D. Forte P434 - Using selective serotonin re-uptake inhibitors and serotonin-norepinephrine re-uptake inhibitors in critical care: a systematic review of the evidence for benefit or harm J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min P435 - Measuring adaptive coping of hospitalized patients with a severe medical condition:the sickness insight in coping questionnaire (sicq) E. Boezeman, J. Hofhuis , A. Hovingh, R. De Vries, P. Spronk P436 - Results of a national survey regarding intensive care medicine training G. Cabral-Campello, I. Aragão, T. Cardoso P437 - Work engagement among healthcare professionals in the intensive care unit M. Van Mol, M. Nijkamp, E . Kompanje P438 - Empowering the intensive care practitioners. is it a burnout ameliorating intervention? P. Ostrowski, A. Omar P439 - Icu patients suffer from circadian rhythm desynchronisation K. Kiss , B. Köves, V. Csernus, Z. Molnár P440 - Noise reduction in the ICU: feasible ? Y. Hoydonckx, S. Vanwing, B. Stessel, A. Van Assche, L. Jamaer, J. Dubois P441 - Accidental removal of invasive devices in the critical patient into the bed-washing. does the presence of professional nurse modify his incidence? V. Medo, R. Galvez, J. P. Miranda P442 - Deprivation of liberty safeguards (dols): audit of compliance in a of a 16-bed specialist cancer critical care unit. C. Stone, T. Wigmore P443 - Use of a modified cristal score to predict futility of critical care in the elderly Y. Arunan, A. Wheeler, K. Bauchmuller, D. Bryden P444 - Improvement of Referral Rate to Palliative Care for Patients with Poor Prognosis in Neurosurgical Intensive Care Unit Y. Wong, C. Poi, C. Gu P445 - Factors associated with limitation of life supporting care (lsc) in a medico-surgical intermediate care unit, and outcome of patients with lsc limitation: a monocentric, six-month study. P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat P446 - Palliative care consultation and intensive care unit admission request: a cohort study J. Ramos, M. Correa, R. T. Carvalho, D. Forte P447 - Nursing and medicine together in postsurgical intensive care unit: situations of prognostic conflict at the end of life. our critical care nurses suffer with our medical activism? A. Fernandez, C. McBride P448 - End of life who may decide E. Koonthalloor, C. Walsh P449 - Correctly diagnosing death A. Webber, M. Ashe, K. Smith, P. Jeanrenaud P450 - Skin procurement performed by intensive care physicians: yes, we can. A. Marudi , S. Baroni, F. Ragusa, E. Bertellini P451 - Death analysis in pediatric intensive care patients E. A. Volakli , E. Chochliourou, M. Dimitriadou, A. Violaki, P. Mantzafleri, E. Samkinidou, O. Vrani, A. Arbouti, T. Varsami, M. Sdougka P452 - The potential impact of euthanasia on organ donation: analysis of data from belgium J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook P453 - Communication within an intensive care setting K. Sim, A. Fuller P454 - Development and implementation of a longitudinal communication curriculum for critical care medicine fellows A. Roze des Ordons, P. Couillard, C. Doig P455 - Staff-family conflict in a multi-ethnic intensive care unit R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen P456 - Does the source of admission to critical care affect family satisfaction? B. Nyamaizi, C. Dalrymple, A. Molokhia, A. Dobru P457 - A simple alternative to the family satisfaction survey (fs-icu) E. Marrinan, A. Ankuli, A. Molokhia P458 - A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis J. McPeake, R. Struthers, R. Crawford , H. Devine , P. Mactavish , T. Quasim P459 - Prevalence and risk factors of anxiety and depression in relatives of burn patients. P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, F. Verga, J. Cabrera, G. Burghi P460 - Guidance of visiting children at an adult intensive care unit (icu) A. Rutten , S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen P461 - Visiting policies in Italian pediatric ICUs: an update A. Giannini, G Miccinesi, T Marchesi, E Prandi FAU - Bateman, R M AU - Bateman RM AD - University of Western Ontario, London, Canada. ISNI: 0000 0004 1936 8884. GRID: grid.39381.30 FAU - Sharpe, M D AU - Sharpe MD AD - University of Western Ontario, London, Canada. ISNI: 0000 0004 1936 8884. GRID: grid.39381.30 FAU - Jagger, J E AU - Jagger JE AD - University of Western Ontario, London, Canada. ISNI: 0000 0004 1936 8884. GRID: grid.39381.30 FAU - Ellis, C G AU - Ellis CG FAU - Solé-Violán, J AU - Solé-Violán J AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - López-Rodríguez, M AU - López-Rodríguez M AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - Herrera-Ramos, E AU - Herrera-Ramos E AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - Ruíz-Hernández, J AU - Ruíz-Hernández J AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - Borderías, L AU - Borderías L AD - Hospital San Jorge, Huesca, Spain. ISNI: 0000 0004 1765 5935. GRID: grid.415076.1 FAU - Horcajada, J AU - Horcajada J AD - Hospital Universitari del Mar, Barcelona, Spain. ISNI: 0000 0004 1767 8811. GRID: grid.411142.3 FAU - González-Quevedo, N AU - González-Quevedo N AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - Rajas, O AU - Rajas O AD - Hospital Universitario de la Princesa, Madrid, Spain. ISNI: 0000 0004 1767 647X. GRID: grid.411251.2 FAU - Briones, M AU - Briones M AD - Hospital Clínico y Universitario de Valencia, Valencia, Spain. GRID: grid.411308.f FAU - Rodríguez de Castro, F AU - Rodríguez de Castro F AD - Hospital Dr Negrín, Las Palmas de GC, Spain FAU - Rodríguez Gallego, C AU - Rodríguez Gallego C AD - Hospital Universitari Son Espases, Palma de Mallorca, Spain. ISNI: 0000 0004 1796 5984. GRID: grid.411164.7 FAU - Esen, F AU - Esen F AD - Medical Faculty of Istanbul, Istanbul University, Anesthesiology and Intensive Care, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Orhun, G AU - Orhun G AD - Medical Faculty of Istanbul, Istanbul University, Anesthesiology and Intensive Care, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Ergin Ozcan, P AU - Ergin Ozcan P AD - Medical Faculty of Istanbul, Istanbul University, Anesthesiology and Intensive Care, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Senturk, E AU - Senturk E AD - Medical Faculty of Istanbul, Istanbul University, Anesthesiology and Intensive Care, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Ugur Yilmaz, C AU - Ugur Yilmaz C AD - Medical Faculty of Istanbul, Physiology, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Orhan, N AU - Orhan N AD - Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Arican, N AU - Arican N AD - Medical Faculty of Istanbul, Forensic Medicine, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Kaya, M AU - Kaya M AD - Medical Faculty of Istanbul, Physiology, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Kucukerden, M AU - Kucukerden M AD - Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Giris, M AU - Giris M AD - Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Akcan, U AU - Akcan U AD - Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Bilgic Gazioglu, S AU - Bilgic Gazioglu S AD - Institute of Experimental Medicine, Immunology, Istanbul University, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Tuzun, E AU - Tuzun E AD - Institute of Experimental Medicine, Istanbul University, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Riff, R AU - Riff R AD - Ben-Gurion University of the Negev, Beer-Sheva, Israel. ISNI: 0000 0004 1937 0511. GRID: grid.7489.2 FAU - Naamani, O AU - Naamani O AD - Ben-Gurion University of the Negev, Beer-Sheva, Israel. ISNI: 0000 0004 1937 0511. GRID: grid.7489.2 FAU - Douvdevani, A AU - Douvdevani A AD - Soroka Medical Center, Beer-Sheva, Israel. ISNI: 0000 0004 0470 8989. GRID: grid.412686.f FAU - Takegawa, R AU - Takegawa R AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Yoshida, H AU - Yoshida H AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Hirose, T AU - Hirose T AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Yamamoto, N AU - Yamamoto N AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Hagiya, H AU - Hagiya H AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ojima, M AU - Ojima M AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Akeda, Y AU - Akeda Y AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Tasaki, O AU - Tasaki O AD - Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ISNI: 0000 0000 8902 2273. GRID: grid.174567.6 FAU - Tomono, K AU - Tomono K AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Shimazu, T AU - Shimazu T AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ono, S AU - Ono S AD - Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo Japan. GRID: grid.411909.4 FAU - Kubo, T AU - Kubo T AD - National Defense Medical College, Tokorozawa, Saitama Japan. ISNI: 0000 0004 0374 0880. GRID: grid.416614.0 FAU - Suda, S AU - Suda S AD - Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo Japan. GRID: grid.411909.4 FAU - Ueno, T AU - Ueno T AD - Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo Japan. GRID: grid.411909.4 FAU - Ikeda, T AU - Ikeda T AD - Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo Japan. GRID: grid.411909.4 FAU - Hirose, T AU - Hirose T AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ogura, H AU - Ogura H AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Takahashi, H AU - Takahashi H AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ojima, M AU - Ojima M AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Kang, J AU - Kang J AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Nakamura, Y AU - Nakamura Y AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Kojima, T AU - Kojima T AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Shimazu, T AU - Shimazu T AD - Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ikeda, T AU - Ikeda T AD - Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Suda, S AU - Suda S AD - Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Izutani, Y AU - Izutani Y AD - Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ueno, T AU - Ueno T AD - Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ono, S AU - Ono S AD - Hachiouji medical center, Tokyo medical university, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Taniguchi, T AU - Taniguchi T AD - Kanazawa University, Kanazawa, Japan. ISNI: 0000 0001 2308 3329. GRID: grid.9707.9 FAU - O, M AU - O M AD - Kanazawa University Hospital, Kanazawa, Japan. ISNI: 0000 0004 0615 9100. GRID: grid.412002.5 FAU - Dinter, C AU - Dinter C AD - ThermoFisher, Hennigsdorf, Germany FAU - Lotz, J AU - Lotz J AD - Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany FAU - Eilers, B AU - Eilers B AD - MVZ Labor Limbach Gruppe, Berlin, Germany FAU - Wissmann, C AU - Wissmann C AD - ThermoFisher, Hennigsdorf, Germany FAU - Lott, R AU - Lott R AD - Institut für Klinische Chemie und Laboratoriumsmedizin, Mainz, Germany FAU - Meili, M M AU - Meili MM AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schuetz, P S AU - Schuetz PS AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Hawa, H AU - Hawa H AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Sharshir, M AU - Sharshir M AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Aburageila, M AU - Aburageila M AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Salahuddin, N AU - Salahuddin N AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Chantziara, V AU - Chantziara V AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Georgiou, S AU - Georgiou S AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Tsimogianni, A AU - Tsimogianni A AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Alexandropoulos, P AU - Alexandropoulos P AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Vassi, A AU - Vassi A AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Lagiou, F AU - Lagiou F AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Valta, M AU - Valta M AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Micha, G AU - Micha G AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Chinou, E AU - Chinou E AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Michaloudis, G AU - Michaloudis G AD - Saint Savvas Hospital, Athens, Greece. GRID: grid.416564.4 FAU - Kodaira, A AU - Kodaira A AD - Tokyo Medical University, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ikeda, T AU - Ikeda T AD - Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 FAU - Ono, S AU - Ono S AD - Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 FAU - Ueno, T AU - Ueno T AD - Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 FAU - Suda, S AU - Suda S AD - Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 FAU - Izutani, Y AU - Izutani Y AD - Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan. GRID: grid.411909.4 FAU - Imaizumi, H AU - Imaizumi H AD - Tokyo Medical University, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - De la Torre-Prados, M V AU - De la Torre-Prados MV AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Garcia-De la Torre, A AU - Garcia-De la Torre A AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Enguix-Armada, A AU - Enguix-Armada A AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Puerto-Morlan, A AU - Puerto-Morlan A AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Perez-Valero, V AU - Perez-Valero V AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Garcia-Alcantara, A AU - Garcia-Alcantara A AD - Hospital Virgen de la Victoria, Málaga, Spain. ISNI: 0000 0000 9788 2492. GRID: grid.411062.0 FAU - Bolton, N AU - Bolton N AD - St Helens and Knowsley NHS Trust, Merseyside, UK FAU - Dudziak, J AU - Dudziak J AD - St Helens and Knowsley NHS Trust, Merseyside, UK FAU - Bonney, S AU - Bonney S AD - St Helens and Knowsley NHS Trust, Merseyside, UK FAU - Tridente, A AU - Tridente A AD - St Helens and Knowsley NHS Trust, Merseyside, UK FAU - Nee, P AU - Nee P AD - St Helens and Knowsley NHS Trust, Merseyside, UK FAU - Nicolaes, G AU - Nicolaes G AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Wiewel, M AU - Wiewel M AD - Center for Experimental and Molecular medicine, Amsterdam, Netherlands FAU - Schultz, M AU - Schultz M AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Wildhagen, K AU - Wildhagen K AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Horn, J AU - Horn J AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Schrijver, R AU - Schrijver R AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Van der Poll, T AU - Van der Poll T AD - Center for Experimental and Molecular medicine, Amsterdam, Netherlands FAU - Reutelingsperger, C AU - Reutelingsperger C AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Pillai, S AU - Pillai S AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Davies, G AU - Davies G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Mills, G AU - Mills G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Aubrey, R AU - Aubrey R AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Morris, K AU - Morris K AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Williams, P AU - Williams P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Evans, P AU - Evans P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Gayat, E G AU - Gayat EG AD - Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 FAU - Struck, J AU - Struck J AD - Sphingotec, Berlin, Germany FAU - Cariou, A AU - Cariou A AD - Hôpital Cochin, Paris, France. ISNI: 0000 0001 0274 3893. GRID: grid.411784.f FAU - Deye, N AU - Deye N AD - Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 FAU - Guidet, B AU - Guidet B AD - Hôpital Saint-Antoine, Paris, France. ISNI: 0000 0004 1937 1100. GRID: grid.412370.3 FAU - Jabert, S AU - Jabert S AD - CHRU de Montpellier, Montpellier, France. ISNI: 0000 0000 9961 060X. GRID: grid.157868.5 FAU - Launay, J AU - Launay J AD - Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 FAU - Legrand, M AU - Legrand M AD - Hôpital Saint-Louis, Paris, France. ISNI: 0000 0001 2300 6614. GRID: grid.413328.f FAU - Léone, M AU - Léone M AD - AP-HM, Marseille, France. ISNI: 0000 0001 0407 1584. GRID: grid.414336.7 FAU - Resche-Rigon, M AU - Resche-Rigon M AD - Hôpital Saint-Louis, Paris, France. ISNI: 0000 0001 2300 6614. GRID: grid.413328.f FAU - Vicaut, E AU - Vicaut E AD - Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 FAU - Vieillard-Baron, A AU - Vieillard-Baron A AD - Hôpital Ambroise Paré, Paris, France. ISNI: 0000 0000 9982 5352. GRID: grid.413756.2 FAU - Mebazaa, A AU - Mebazaa A AD - Hôpital Lariboisière, Paris, France. ISNI: 0000 0000 9725 279X. GRID: grid.411296.9 FAU - Arnold, R AU - Arnold R AD - Christiana Care Health System, Newark, USA. ISNI: 0000 0004 0444 1241. GRID: grid.414316.5 FAU - Capan, M AU - Capan M AD - Christiana Care Health System, Newark, USA. ISNI: 0000 0004 0444 1241. GRID: grid.414316.5 FAU - Linder, A AU - Linder A AD - Skane University Hospital, Lund University, Lund, Sweden. ISNI: 0000 0001 0930 2361. GRID: grid.4514.4 FAU - Akesson, P AU - Akesson P AD - Skane University Hospital, Lund University, Lund, Sweden. ISNI: 0000 0001 0930 2361. GRID: grid.4514.4 FAU - Popescu, M AU - Popescu M AD - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. ISNI: 0000 0000 9828 7548. GRID: grid.8194.4 FAU - Tomescu, D AU - Tomescu D AD - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. ISNI: 0000 0000 9828 7548. GRID: grid.8194.4 FAU - Sprung, C L AU - Sprung CL AD - Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 FAU - Calderon Morales, R AU - Calderon Morales R AD - Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 FAU - Munteanu, G AU - Munteanu G AD - Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 FAU - Orenbuch-Harroch, E AU - Orenbuch-Harroch E AD - Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 FAU - Levin, P AU - Levin P AD - Hadassah-Hebrew University Medical Center, Jerusalem, Israel. ISNI: 0000 0001 2221 2926. GRID: grid.17788.31 FAU - Kasdan, H AU - Kasdan H AD - LeukoDx, Jerusalem, Israel FAU - Reiter, A AU - Reiter A AD - LeukoDx, Jerusalem, Israel FAU - Volker, T AU - Volker T AD - LeukoDx, Jerusalem, Israel FAU - Himmel, Y AU - Himmel Y AD - LeukoDx, Jerusalem, Israel FAU - Cohen, Y AU - Cohen Y AD - LeukoDx, Jerusalem, Israel FAU - Meissonnier, J AU - Meissonnier J AD - LeukoDx, Jerusalem, Israel FAU - Girard, L AU - Girard L AD - Abionic SA, Lausanne, Switzerland FAU - Rebeaud, F AU - Rebeaud F AD - Abionic SA, Lausanne, Switzerland FAU - Herrmann, I AU - Herrmann I AD - Swiss Federal Laboratories (Empa), St. Gallen, Switzerland FAU - Delwarde, B AU - Delwarde B AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Peronnet, E AU - Peronnet E AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Cerrato, E AU - Cerrato E AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Venet, F AU - Venet F AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Lepape, A AU - Lepape A AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Rimmelé, T AU - Rimmelé T AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Monneret, G AU - Monneret G AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Textoris, J AU - Textoris J AD - Pathophysiology of injury induced immunosuppression (PI3) Lab, Lyon 1 University / Hospices Civils de Lyon / bioMérieux, Lyon, France FAU - Beloborodova, N AU - Beloborodova N AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Moroz, V AU - Moroz V AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Osipov, A AU - Osipov A AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Bedova, A AU - Bedova A AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Sarshor, Y AU - Sarshor Y AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Pautova, A AU - Pautova A AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Sergeev, A AU - Sergeev A AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Chernevskaya, E AU - Chernevskaya E AD - Negovsky V.A. Research Institute of General Reanimatology, Moscow, Russia FAU - Odermatt, J AU - Odermatt J AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Bolliger, R AU - Bolliger R AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Hersberger, L AU - Hersberger L AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Ottiger, M AU - Ottiger M AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Christ-Crain, M AU - Christ-Crain M AD - University Hospital Basel, Basel, Switzerland. GRID: grid.410567.1 FAU - Mueller, B AU - Mueller B AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schuetz, P AU - Schuetz P AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Sharma, N K AU - Sharma NK AD - UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b FAU - Tashima, A K AU - Tashima AK AD - UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b FAU - Brunialti, M K AU - Brunialti MK AD - UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b FAU - Machado, F R AU - Machado FR AD - UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b FAU - Assuncao, M AU - Assuncao M AD - Albert Einstein Hospital, Sao Paulo, Brazil. ISNI: 0000 0001 0385 1941. GRID: grid.413562.7 FAU - Rigato, O AU - Rigato O AD - Sírio Libanês Hospital, Sao Paulo, Brazil FAU - Salomao, R AU - Salomao R AD - UNIFESP, Sao Paulo, Brazil. ISNI: 0000 0001 0514 7202. GRID: grid.411249.b FAU - Cajander, S C AU - Cajander SC AD - Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 FAU - Rasmussen, G AU - Rasmussen G AD - Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 FAU - Tina, E AU - Tina E AD - Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 FAU - Söderquist, B AU - Söderquist B AD - Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 FAU - Källman, J AU - Källman J AD - Faculty of Medicine and Health Örebro University, Örebro, Sweden. ISNI: 0000 0001 0738 8966. GRID: grid.15895.30 FAU - Strålin, K AU - Strålin K AD - Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden. ISNI: 0000 0000 9241 5705. GRID: grid.24381.3c FAU - Lange, A L AU - Lange AL AD - Faculty of Medicine and Health, Örebro, Sweden FAU - Sundén-Cullberg, J S AU - Sundén-Cullberg JS AD - Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. ISNI: 0000 0000 9241 5705. GRID: grid.24381.3c FAU - Magnuson, A M AU - Magnuson AM AD - Faculty of Medicine and Health, Örebro, Sweden FAU - Hultgren, O H AU - Hultgren OH AD - Faculty of Medicine and Health, Örebro, Sweden FAU - Davies, G AU - Davies G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Pillai, S AU - Pillai S AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Mills, G AU - Mills G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Aubrey, R AU - Aubrey R AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Morris, K AU - Morris K AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Williams, P AU - Williams P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Evans, P AU - Evans P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Pillai, S AU - Pillai S AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Davies, G AU - Davies G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Mills, G AU - Mills G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Aubrey, R AU - Aubrey R AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Morris, K AU - Morris K AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Williams, P AU - Williams P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Evans, P AU - Evans P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Pillai, S AU - Pillai S AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Davies, G AU - Davies G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Mills, G AU - Mills G AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Aubrey, R AU - Aubrey R AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Morris, K AU - Morris K AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Williams, P AU - Williams P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Evans, P AU - Evans P AD - NISCHR Haemostasis Biomarker Research Unit, Swansea, UK FAU - Van der Geest, P AU - Van der Geest P AD - Erasmus Medical Center, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Mohseni, M AU - Mohseni M AD - Erasmus Medical Center, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Linssen, J AU - Linssen J AD - University Witten/Herdecke, Witten, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - De Jonge, R AU - De Jonge R AD - Erasmus Medical Center, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Duran, S AU - Duran S AD - Maasstad Ziekenhuis, Rotterdam, Netherlands. ISNI: 0000 0004 0460 0556. GRID: grid.416213.3 FAU - Groeneveld, J AU - Groeneveld J AD - Erasmus Medical Center, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Miller, R III AU - Miller R III AD - Intermountain Healthcare, Salt Lake City, USA. ISNI: 0000 0004 0460 774X. GRID: grid.420884.2 FAU - Lopansri, B K AU - Lopansri BK AD - Intermountain Healthcare, Salt Lake City, USA. ISNI: 0000 0004 0460 774X. GRID: grid.420884.2 FAU - McHugh, L C AU - McHugh LC AD - Immunexpress, Seattle, USA FAU - Seldon, A AU - Seldon A AD - Immunexpress, Seattle, USA FAU - Burke, J P AU - Burke JP AD - Intermountain Healthcare, Salt Lake City, USA. ISNI: 0000 0004 0460 774X. GRID: grid.420884.2 FAU - Johnston, J AU - Johnston J AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Reece-Anthony, R AU - Reece-Anthony R AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Bond, A AU - Bond A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Molokhia, A AU - Molokhia A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Mcgrath, C AU - Mcgrath C AD - Wirral trust, Merseyside, UK FAU - Nsutebu, E AU - Nsutebu E AD - RLBUHT, Liverpool, UK FAU - Bank Pedersen, P AU - Bank Pedersen P AD - Department of Emergency Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 FAU - Pilsgaard Henriksen, D AU - Pilsgaard Henriksen D AD - Department of Respiratory Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 FAU - Mikkelsen, S AU - Mikkelsen S AD - Department of Anaesthesiology and Intensive Care Medicine, Odense University Hospital, Odense C, Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1 FAU - Touborg Lassen, A AU - Touborg Lassen A AD - Wirral trust, Merseyside, UK FAU - Tincu, R AU - Tincu R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Cobilinschi, C AU - Cobilinschi C AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Tomescu, D AU - Tomescu D AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Ghiorghiu, Z AU - Ghiorghiu Z AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Macovei, R AU - Macovei R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Wiewel, M A AU - Wiewel MA AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Harmon, M B AU - Harmon MB AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Vught, L A AU - Van Vught LA AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Scicluna, B P AU - Scicluna BP AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Hoogendijk, A J AU - Hoogendijk AJ AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Horn, J AU - Horn J AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Zwinderman, A H AU - Zwinderman AH AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Cremer, O L AU - Cremer OL AD - University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a FAU - Bonten, M J AU - Bonten MJ AD - University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a FAU - Schultz, M J AU - Schultz MJ AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van der Poll, T AU - Van der Poll T AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Juffermans, N P AU - Juffermans NP AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Wiersinga, W J AU - Wiersinga WJ AD - Amsterdam Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Eren, G AU - Eren G AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Tekdos, Y AU - Tekdos Y AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Dogan, M AU - Dogan M AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Acicbe, O AU - Acicbe O AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Kaya, E AU - Kaya E AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Hergunsel, O AU - Hergunsel O AD - Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey. ISNI: 0000 0004 0419 1043. GRID: grid.414177.0 FAU - Alsolamy, S AU - Alsolamy S AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Ghamdi, G AU - Ghamdi G AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alswaidan, L AU - Alswaidan L AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alharbi, S AU - Alharbi S AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alenezi, F AU - Alenezi F AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Arabi, Y AU - Arabi Y AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Heaton, J AU - Heaton J AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Boyce, A AU - Boyce A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Nolan, L AU - Nolan L AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Johnston, J AU - Johnston J AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Dukoff-Gordon, A AU - Dukoff-Gordon A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Dean, A AU - Dean A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Molokhia, A AU - Molokhia A AD - Lewisham and Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Mann Ben Yehudah, T AU - Mann Ben Yehudah T AD - Assaf Harofeh MC, Beer Yaakov, Israel FAU - Fleischmann, C AU - Fleischmann C AD - Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Thomas-Rueddel, D AU - Thomas-Rueddel D AD - Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Haas, C AU - Haas C AD - Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Dennler, U AU - Dennler U AD - Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Reinhart, K AU - Reinhart K AD - Jena University Hopital, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Suntornlohanakul, O AU - Suntornlohanakul O AD - Prince of Songkla University, Hat Yai, Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Khwannimit, B AU - Khwannimit B AD - Division of Critical Care Medicine, Hat Yai, Thailand FAU - Breckenridge, F AU - Breckenridge F AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Puxty, A AU - Puxty A AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Szturz, P AU - Szturz P AD - University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic. ISNI: 0000 0004 0609 0692. GRID: grid.412727.5 FAU - Folwarzcny, P AU - Folwarzcny P AD - University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic. ISNI: 0000 0004 0609 0692. GRID: grid.412727.5 FAU - Svancara, J AU - Svancara J AD - Institute of Biostatistics and analyses, Masaryk University, Brno, Czech Republic. ISNI: 0000 0001 2194 0956. GRID: grid.10267.32 FAU - Kula, R AU - Kula R AD - University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic. ISNI: 0000 0004 0609 0692. GRID: grid.412727.5 FAU - Sevcik, P AU - Sevcik P AD - University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic. ISNI: 0000 0004 0609 0692. GRID: grid.412727.5 FAU - Caneva, L AU - Caneva L AD - Università degli studi di Pavia, scuola di specialità: Anestesia e Rianimazione, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Casazza, A AU - Casazza A AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Bellazzi, E AU - Bellazzi E AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Marra, S AU - Marra S AD - Università degli studi di Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Pagani, L AU - Pagani L AD - Università degli studi di Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Vetere, M AU - Vetere M AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Vanzino, R AU - Vanzino R AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Ciprandi, D AU - Ciprandi D AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Preda, R AU - Preda R AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Boschi, R AU - Boschi R AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Carnevale, L AU - Carnevale L AD - UOC Anestesia e Rianimazione Ospedale Civile di Vigevano, AO Pavia, Vigevano, Italy FAU - Lopez, V AU - Lopez V AD - Hospital O’horan, Mérida, Mexico FAU - Aguilar Arzapalo, M AU - Aguilar Arzapalo M AD - Hospital O’horan, Mérida, Mexico FAU - Barradas, L AU - Barradas L AD - Hospital O’horan, Mérida, Mexico FAU - Escalante, A AU - Escalante A AD - Hospital O’horan, Mérida, Mexico FAU - Gongora, J AU - Gongora J AD - Hospital O’horan, Mérida, Mexico FAU - Cetina, M AU - Cetina M AD - Hospital O’horan, Mérida, Mexico FAU - Adamik, B AU - Adamik B AD - Department of Anaesthesiology and Intensive Therapy, Medical University, Wroclaw, Poland. ISNI: 0000 0001 1090 049X. GRID: grid.4495.c FAU - Jakubczyk, D AU - Jakubczyk D AD - Department of Anaesthesiology and Intensive Therapy, Medical University, Wroclaw, Poland. ISNI: 0000 0001 1090 049X. GRID: grid.4495.c FAU - Kübler, A AU - Kübler A AD - Department of Anaesthesiology and Intensive Therapy, Medical University, Wroclaw, Poland. ISNI: 0000 0001 1090 049X. GRID: grid.4495.c FAU - Radford, A AU - Radford A AD - AKPA, Waltham, USA FAU - Lee, T AU - Lee T AD - St. Paul’s Hospital, Vancouver, Canada. ISNI: 0000 0000 8589 2327. GRID: grid.416553.0 FAU - Singer, J AU - Singer J AD - St. Paul’s Hospital, Vancouver, Canada. ISNI: 0000 0000 8589 2327. GRID: grid.416553.0 FAU - Boyd, J AU - Boyd J AD - St. Paul’s Hospital, Vancouver, Canada. ISNI: 0000 0000 8589 2327. GRID: grid.416553.0 FAU - Fineberg, D AU - Fineberg D AD - AKPA, Waltham, USA FAU - Williams, M AU - Williams M AD - AKPA, Waltham, USA FAU - Russell, J AU - Russell J AD - St. Paul’s Hospital, Vancouver, Canada. ISNI: 0000 0000 8589 2327. GRID: grid.416553.0 FAU - Scarlatescu, E AU - Scarlatescu E AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Tomescu, D AU - Tomescu D AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Droc, G AU - Droc G AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Arama, S AU - Arama S AD - University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania. ISNI: 0000 0000 9828 7548. GRID: grid.8194.4 FAU - Müller, M AU - Müller M AD - Acedemisch Medisch Centrum, Amsterdam, Netherlands FAU - Straat, M AU - Straat M AD - Acedemisch Medisch Centrum, Amsterdam, Netherlands FAU - Zeerleder, S S AU - Zeerleder SS AD - Acedemisch Medisch Centrum, Amsterdam, Netherlands FAU - Juffermans, N P AU - Juffermans NP AD - Acedemisch Medisch Centrum, Amsterdam, Netherlands FAU - Fuchs, C F AU - Fuchs CF AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Scheer, C S AU - Scheer CS AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Wauschkuhn, S W AU - Wauschkuhn SW AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Vollmer, M V AU - Vollmer MV AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Meissner, K M AU - Meissner KM AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Kuhn, S K AU - Kuhn SK AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Hahnenkamp, K H AU - Hahnenkamp KH AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Rehberg, S R AU - Rehberg SR AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Gründling, M G AU - Gründling MG AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Yamamoto, N AU - Yamamoto N AD - Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Ojima, M AU - Ojima M AD - Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Hamaguchi, S AU - Hamaguchi S AD - Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Hirose, T AU - Hirose T AD - Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Akeda, Y AU - Akeda Y AD - Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Takegawa, R AU - Takegawa R AD - Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Tasaki, O AU - Tasaki O AD - Department of Emergency Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. ISNI: 0000 0000 8902 2273. GRID: grid.174567.6 FAU - Shimazu, T AU - Shimazu T AD - Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Tomono, K AU - Tomono K AD - Division of Infection Control and Prevention, Osaka University Graduate School of Medicine, Suita, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Gómez-Sánchez, E AU - Gómez-Sánchez E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Heredia-Rodríguez, M AU - Heredia-Rodríguez M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Álvarez-Fuente, E AU - Álvarez-Fuente E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Lorenzo-López, M AU - Lorenzo-López M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Gómez-Pesquera, E AU - Gómez-Pesquera E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Aragón-Camino, M AU - Aragón-Camino M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Liu-Zhu, P AU - Liu-Zhu P AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Sánchez-López, A AU - Sánchez-López A AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Hernández-Lozano, A AU - Hernández-Lozano A AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Peláez-Jareño, M T AU - Peláez-Jareño MT AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Tamayo, E AU - Tamayo E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Thomas-Rüddel, D O AU - Thomas-Rüddel DO AD - Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 FAU - Fleischmann, C AU - Fleischmann C AD - Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 FAU - Haas, C AU - Haas C AD - Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 FAU - Dennler, U AU - Dennler U AD - Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 FAU - Reinhart, K AU - Reinhart K AD - Jena University Hospital, Jena, Germany. ISNI: 0000 0000 8517 6224. GRID: grid.275559.9 FAU - Adora, V AU - Adora V AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Kar, A AU - Kar A AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Chakraborty, A AU - Chakraborty A AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Roy, S AU - Roy S AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Bandyopadhyay, A AU - Bandyopadhyay A AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Das, M AU - Das M AD - Medica Superspecialty Hospital, Kolkata, West Bengal India FAU - Mann Ben Yehudah, T AU - Mann Ben Yehudah T AD - Assaf Harofeh MC, Beer Yaakov, Israel FAU - BenYehudah, G AU - BenYehudah G AD - Assaf Harofeh MC, Beer Yaakov, Israel FAU - Salim, M AU - Salim M AD - DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b FAU - Kumar, N AU - Kumar N AD - DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b FAU - Arabi, L AU - Arabi L AD - DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b FAU - Burger, T AU - Burger T AD - DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b FAU - Lephart, P AU - Lephart P AD - DMC, Detroit, USA. ISNI: 0000 0001 0088 6903. GRID: grid.413184.b FAU - Toth-martin, E AU - Toth-martin E AD - Wayne State University, Detroit, USA. ISNI: 0000 0001 1456 7807. GRID: grid.254444.7 FAU - Valencia, C AU - Valencia C AD - Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium. ISNI: 0000 0004 0635 3376. GRID: grid.418170.b FAU - Hammami, N AU - Hammami N AD - Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium. ISNI: 0000 0004 0635 3376. GRID: grid.418170.b FAU - Blot, S AU - Blot S AD - Ghent University, Ghent, Belgium. ISNI: 0000 0001 2069 7798. GRID: grid.5342.0 FAU - Vincent, J L AU - Vincent JL AD - Erasme University, Brussels, Belgium FAU - Lambert, M L AU - Lambert ML AD - Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium. ISNI: 0000 0004 0635 3376. GRID: grid.418170.b FAU - Brunke, J AU - Brunke J AD - QualityLabs Bt GmbH, Nuremberg, Germany FAU - Riemann, T AU - Riemann T AD - B.Braun Melsungen AG, Melsungen, Germany. ISNI: 0000 0001 0699 8877. GRID: grid.462046.2 FAU - Roschke, I AU - Roschke I AD - Dr. Roschke medical marketing GmbH, Cologne, Germany FAU - Tincu, R AU - Tincu R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Cobilinschi, C AU - Cobilinschi C AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Tomescu, D AU - Tomescu D AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Ghiorghiu, Z AU - Ghiorghiu Z AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Macovei, R AU - Macovei R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Nimitvilai, S AU - Nimitvilai S AD - Nakhonpathom hospital, Nakhonpathom, Thailand FAU - Jintanapramote, K AU - Jintanapramote K AD - Nakhonpathom hospital, Nakhonpathom, Thailand FAU - Jarupongprapa, S AU - Jarupongprapa S AD - Nakhonpathom hospital, Nakhonpathom, Thailand FAU - Adukauskiene, D AU - Adukauskiene D AD - Lithuanian University of Health Sciences, Kaunas,, Lithuania. ISNI: 0000 0004 0432 6841. GRID: grid.45083.3a FAU - Valanciene, D AU - Valanciene D AD - Lithuanian University of Health Sciences, Kaunas,, Lithuania. ISNI: 0000 0004 0432 6841. GRID: grid.45083.3a FAU - Bose, G AU - Bose G AD - University Hospital North Midlands, Stoke-on-Trent, UK FAU - Lostarakos, V AU - Lostarakos V AD - University Hospital North Midlands, Stoke-on-Trent, UK FAU - Carr, B AU - Carr B AD - University Hospital North Midlands, Stoke-on-Trent, UK FAU - Khedher, S AU - Khedher S AD - EPS Charles-Nicolle, Bab Saadoun, Tunisia FAU - Maaoui, A AU - Maaoui A AD - EPS Charles-Nicolle, Bab Saadoun, Tunisia FAU - Ezzamouri, A AU - Ezzamouri A AD - EPS Charles-Nicolle, Bab Saadoun, Tunisia FAU - Salem, M AU - Salem M AD - EPS Charles-Nicolle, Bab Saadoun, Tunisia FAU - Chen, J AU - Chen J AD - Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan FAU - Cranendonk, D R AU - Cranendonk DR AD - Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. ISNI: 0000000084992262. GRID: grid.7177.6 FAU - Van Vught, L A AU - Van Vught LA AD - Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands FAU - Wiewel, M A AU - Wiewel MA AD - Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands FAU - Cremer, O L AU - Cremer OL AD - Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a FAU - Horn, J AU - Horn J AD - Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Bonten, M J AU - Bonten MJ AD - Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a FAU - Schultz, M J AU - Schultz MJ AD - Department of Intensive Care Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van der Poll, T AU - Van der Poll T AD - Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands FAU - Wiersinga, W J AU - Wiersinga WJ AD - Academic Medical Center, University of Amsterdam, Center for Experimental and Molecular Medicine, Amsterdam, Netherlands FAU - Day, M AU - Day M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Penrice, G AU - Penrice G AD - NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Roy, K AU - Roy K AD - Health Protection Scotland, Glasgow, UK. ISNI: 0000 0001 2232 4338. GRID: grid.413893.4 FAU - Robertson, P AU - Robertson P AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Godbole, G AU - Godbole G AD - Public Health England, London, UK. ISNI: 0000 0001 2196 8713. GRID: grid.9004.d FAU - Jones, B AU - Jones B AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Booth, M AU - Booth M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Donaldson, L AU - Donaldson L AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kawano, Y AU - Kawano Y AD - Fukuoka University Hospital, Fukuoka, Japan. ISNI: 0000 0004 0594 9821. GRID: grid.411556.2 FAU - Ishikura, H AU - Ishikura H AD - Fukuoka University Hospital, Fukuoka, Japan. ISNI: 0000 0004 0594 9821. GRID: grid.411556.2 FAU - Al-Dorzi, H AU - Al-Dorzi H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Almutairi, M AU - Almutairi M AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alhamadi, B AU - Alhamadi B AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Crizaldo Toledo, A AU - Crizaldo Toledo A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Khan, R AU - Khan R AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Al Raiy, B AU - Al Raiy B AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Arabi, Y AU - Arabi Y AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Talaie, H AU - Talaie H AD - Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. GRID: grid.411600.2 FAU - Van Oers, J A AU - Van Oers JA AD - St. Elisabeth Hospital, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Harts, A AU - Harts A AD - St. Elisabeth Hospital, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Nieuwkoop, E AU - Nieuwkoop E AD - St. Elisabeth Hospital, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Vos, P AU - Vos P AD - St. Elisabeth Hospital, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Boussarsar, Y AU - Boussarsar Y AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Boutouta, F AU - Boutouta F AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Kamoun, S AU - Kamoun S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mezghani, I AU - Mezghani I AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Koubaji, S AU - Koubaji S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Ben Souissi, A AU - Ben Souissi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Riahi, A AU - Riahi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mebazaa, M S AU - Mebazaa MS AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Giamarellos-Bourboulis, E AU - Giamarellos-Bourboulis E AD - University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 FAU - Tziolos, N AU - Tziolos N AD - University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 FAU - Routsi, C AU - Routsi C AD - University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 FAU - Katsenos, C AU - Katsenos C AD - Korgialeneion Benakeion Hospital, Athens, Greece FAU - Tsangaris, I AU - Tsangaris I AD - University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 FAU - Pneumatikos, I AU - Pneumatikos I AD - University of Thrace, Alexandroupolis, Greece. ISNI: 0000 0001 2170 8022. GRID: grid.12284.3d FAU - Vlachogiannis, G AU - Vlachogiannis G AD - Aghios Dimitrios Hospital, Thessaloniki, Greece FAU - Theodorou, V AU - Theodorou V AD - University of Thrace, Alexandroupolis, Greece. ISNI: 0000 0001 2170 8022. GRID: grid.12284.3d FAU - Prekates, A AU - Prekates A AD - Tzaneion Hospital, Piraeus, Greece FAU - Antypa, E AU - Antypa E AD - G.Gennimatas General Hospital, Thessaloniki, Greece. GRID: grid.414012.2 FAU - Koulouras, V AU - Koulouras V AD - University of Ioannina, Ioannina, Greece. ISNI: 0000 0001 2108 7481. GRID: grid.9594.1 FAU - Kapravelos, N AU - Kapravelos N AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Gogos, C AU - Gogos C AD - University of Patras, Patras, Greece. ISNI: 0000 0004 0576 5395. GRID: grid.11047.33 FAU - Antoniadou, E AU - Antoniadou E AD - G.Gennimatas General Hospital, Thessaloniki, Greece. GRID: grid.414012.2 FAU - Mandragos, K AU - Mandragos K AD - Korgialeneion Benakeion Hospital, Athens, Greece FAU - Armaganidis, A AU - Armaganidis A AD - University of Athens, Medical School, Athens, Greece. ISNI: 0000 0001 2155 0800. GRID: grid.5216.0 FAU - Robles Caballero, A R AU - Robles Caballero AR AD - Hospital Universitario La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Civantos, B AU - Civantos B AD - Hospital Universitario La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Figueira, J C AU - Figueira JC AD - Hospital Universitario La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - López, J AU - López J AD - Hospital Universitario La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Silva-Pinto, A AU - Silva-Pinto A AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Ceia, F AU - Ceia F AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Sarmento, A AU - Sarmento A AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Santos, L AU - Santos L AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Almekhlafi, G AU - Almekhlafi G AD - PSMMC, Riyadh, Saudi Arabia FAU - Sakr, Y AU - Sakr Y AD - UNIKLINIKUM JENA, JENA, Germany FAU - Al-Dorzi, H AU - Al-Dorzi H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Khan, R AU - Khan R AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Baharoon, S AU - Baharoon S AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Aldawood, A AU - Aldawood A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Matroud, A AU - Matroud A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alchin, J AU - Alchin J AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Al Johani, S AU - Al Johani S AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Balkhy, H AU - Balkhy H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Arabi, Y AU - Arabi Y AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alsolamy, S AU - Alsolamy S AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Yousif, S Y AU - Yousif SY AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alotabi, B O AU - Alotabi BO AD - King Fahad Medical City, Riyadh, Saudi Arabia. ISNI: 0000 0004 0593 1832. GRID: grid.415277.2 FAU - Alsaawi, A S AU - Alsaawi AS AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Ang, J AU - Ang J AD - Addenbrooke’s Hospital, Cambridge, UK. ISNI: 0000 0004 0622 5016. GRID: grid.120073.7 FAU - Curran, M D AU - Curran MD AD - Addenbrooke’s Hospital, Cambridge, UK. ISNI: 0000 0004 0622 5016. GRID: grid.120073.7 FAU - Enoch, D AU - Enoch D AD - Addenbrooke’s Hospital, Cambridge, UK. ISNI: 0000 0004 0622 5016. GRID: grid.120073.7 FAU - Navapurkar, V AU - Navapurkar V AD - Addenbrooke’s Hospital, Cambridge, UK. ISNI: 0000 0004 0622 5016. GRID: grid.120073.7 FAU - Morris, A AU - Morris A AD - University of Cambridge, Cambridge, UK. ISNI: 0000000121885934. GRID: grid.5335.0 FAU - Sharvill, R AU - Sharvill R AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Astin, J AU - Astin J AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Heredia-Rodríguez, M AU - Heredia-Rodríguez M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Gómez-Sánchez, E AU - Gómez-Sánchez E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Peláez-Jareño, M T AU - Peláez-Jareño MT AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Gómez-Pesquera, E AU - Gómez-Pesquera E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Lorenzo-López, M AU - Lorenzo-López M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Liu-Zhu, P AU - Liu-Zhu P AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Aragón-Camino, M AU - Aragón-Camino M AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Hernández-Lozano, A AU - Hernández-Lozano A AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Sánchez-López, A AU - Sánchez-López A AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Álvarez-Fuente, E AU - Álvarez-Fuente E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Tamayo, E AU - Tamayo E AD - Hospital Clínico Universitario de Valladolid, Valladolid, Spain. ISNI: 0000 0000 9274 367X. GRID: grid.411057.6 FAU - Patel, J AU - Patel J AD - Salford Royal Hospital, London, UK. ISNI: 0000 0000 8535 2371. GRID: grid.415721.4 FAU - Kruger, C AU - Kruger C AD - Salford Royal Hospital, London, UK. ISNI: 0000 0000 8535 2371. GRID: grid.415721.4 FAU - O’Neal, J AU - O’Neal J AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Rhodes, H AU - Rhodes H AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Jancik, J AU - Jancik J AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - François, B AU - François B AD - CHU Dupuytren, Limoges, France. ISNI: 0000 0001 1481 5225. GRID: grid.412212.6 FAU - Laterre, P F AU - Laterre PF AD - St Luc University Hospital, Brussels, Belgium. ISNI: 0000 0004 0461 6320. GRID: grid.48769.34 FAU - Eggimann, P AU - Eggimann P AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Torres, A AU - Torres A AD - Hospital Clinic of Barcelona, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Sánchez, M AU - Sánchez M AD - Hospital Clínico San Carlos, Madrid, Spain. ISNI: 0000 0001 0671 5785. GRID: grid.411068.a FAU - Dequin, P F AU - Dequin PF AD - Université François Rabelais and CHU Bretonneau, Tours, France. ISNI: 0000 0001 2182 6141. GRID: grid.12366.30 FAU - Bassi, G L AU - Bassi GL AD - Hospital Clinic of Barcelona, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Chastre, J AU - Chastre J AD - Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a FAU - Jafri, H S AU - Jafri HS AD - MedImmune, Gaithersburg, USA. GRID: grid.418152.b FAU - Ben Romdhane, M AU - Ben Romdhane M AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Douira, Z AU - Douira Z AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Kamoun, S AU - Kamoun S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Bousselmi, M AU - Bousselmi M AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Ben Souissi, A AU - Ben Souissi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Boussarsar, Y AU - Boussarsar Y AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Riahi, A AU - Riahi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mebazaa, M S AU - Mebazaa MS AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Vakalos, A AU - Vakalos A AD - Xanthi General Hospital, Xanthi, Greece FAU - Avramidis, V AU - Avramidis V AD - Xanthi General Hospital, Xanthi, Greece FAU - Craven, T H AU - Craven TH AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Wojcik, G AU - Wojcik G AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Kefala, K AU - Kefala K AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - McCoubrey, J AU - McCoubrey J AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Reilly, J AU - Reilly J AD - Health Protection Scotland, Glasgow, UK. ISNI: 0000 0001 2232 4338. GRID: grid.413893.4 FAU - Paterson, R AU - Paterson R AD - Western General Hospital, Edinburgh, UK. ISNI: 0000 0004 0624 9907. GRID: grid.417068.c FAU - Inverarity, D AU - Inverarity D AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Laurenson, I AU - Laurenson I AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Walsh, T S AU - Walsh TS AD - Royal Infirmary of Edinburgh, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Mongodi, S AU - Mongodi S AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Bouhemad, B AU - Bouhemad B AD - Centre Hospitalier Universitaire Dijon, Dijon, France. GRID: grid.31151.37 FAU - Orlando, A AU - Orlando A AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Stella, A AU - Stella A AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Via, G AU - Via G AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Iotti, G AU - Iotti G AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Braschi, A AU - Braschi A AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Mojoli, F AU - Mojoli F AD - Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy. ISNI: 0000 0004 1762 5736. GRID: grid.8982.b FAU - Haliloglu, M AU - Haliloglu M AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Bilgili, B AU - Bilgili B AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Kasapoglu, U AU - Kasapoglu U AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Sayan, I AU - Sayan I AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Süzer Aslan, M AU - Süzer Aslan M AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Yalcın, A AU - Yalcın A AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Cinel, I AU - Cinel I AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Vakalos, A AU - Vakalos A AD - Xanthi General Hospital, Xanthi, Greece FAU - Avramidis, V AU - Avramidis V AD - Xanthi General Hospital, Xanthi, Greece FAU - Ellis, H E AU - Ellis HE AD - Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK. GRID: grid.419135.b FAU - Bauchmuller, K AU - Bauchmuller K AD - Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK. GRID: grid.419135.b FAU - Miller, D AU - Miller D AD - Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK. GRID: grid.419135.b FAU - Temple, A AU - Temple A AD - Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK. GRID: grid.419135.b FAU - Chastre, J AU - Chastre J AD - Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a FAU - François, B AU - François B AD - CHU Dupuytren, Limoges, France. ISNI: 0000 0001 1481 5225. GRID: grid.412212.6 FAU - Torres, A AU - Torres A AD - Hospital Clinic of Barcelona, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Luyt, C E AU - Luyt CE AD - Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a FAU - Sánchez, M AU - Sánchez M AD - Hospital Clínico San Carlos, Madrid, Spain. ISNI: 0000 0001 0671 5785. GRID: grid.411068.a FAU - Singer, M AU - Singer M AD - University College, London, UK FAU - Jafri, H S AU - Jafri HS AD - MedImmune, Gaithersburg, USA. GRID: grid.418152.b FAU - Nassar, Y AU - Nassar Y AD - Cairo University, Giza, Egypt. ISNI: 0000 0004 0639 9286. GRID: grid.7776.1 FAU - Ayad, M S AU - Ayad MS AD - Cairo University, Giza, Egypt. ISNI: 0000 0004 0639 9286. GRID: grid.7776.1 FAU - Trifi, A AU - Trifi A AD - University hospital Center of La Rabta, Tunis, Tunisia FAU - Abdellatif, S AU - Abdellatif S AD - University hospital Center of La Rabta, Tunis, Tunisia FAU - Daly, F AU - Daly F AD - University hospital Center of La Rabta, Tunis, Tunisia FAU - Nasri, R AU - Nasri R AD - University hospital Center of La Rabta, Tunis, Tunisia FAU - Ben Lakhal, S AU - Ben Lakhal S AD - University hospital Center of La Rabta, Tunis, Tunisia FAU - Bilgili, B AU - Bilgili B AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Haliloglu, M AU - Haliloglu M AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Gul, F AU - Gul F AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Cinel, I AU - Cinel I AD - Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey. ISNI: 0000 0001 0668 8422. GRID: grid.16477.33 FAU - Kuzovlev, A AU - Kuzovlev A AD - V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia FAU - Shabanov, A AU - Shabanov A AD - N.V. Sklifosofsky Institute of Emergency Medicine, Moscow, Russia FAU - Polovnikov, S AU - Polovnikov S AD - NN Burdenko Main Military Hospital, Moscow, Russia FAU - Moroz, V AU - Moroz V AD - V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia FAU - Kadrichu, N AU - Kadrichu N AD - Novartis Pharmaceuticals, San Carlos, USA. ISNI: 0000 0004 0439 2056. GRID: grid.418424.f FAU - Dang, T AU - Dang T AD - Novartis Pharmaceuticals, San Carlos, USA. ISNI: 0000 0004 0439 2056. GRID: grid.418424.f FAU - Corkery, K AU - Corkery K AD - Novartis Pharmaceuticals, San Carlos, USA. ISNI: 0000 0004 0439 2056. GRID: grid.418424.f FAU - Challoner, P AU - Challoner P AD - Nektar Therapeutics, San Francisco, CA USA. ISNI: 0000 0004 0410 3955. GRID: grid.476522.0 FAU - Bassi, G Li AU - Bassi GL AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Aguilera, E AU - Aguilera E AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Chiurazzi, C AU - Chiurazzi C AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Travierso, C AU - Travierso C AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Motos, A AU - Motos A AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Fernandez, L AU - Fernandez L AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Amaro, R AU - Amaro R AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Senussi, T AU - Senussi T AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Idone, F AU - Idone F AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Bobi, J AU - Bobi J AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Rigol, M AU - Rigol M AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Torres, A AU - Torres A AD - Hospital Clinic, Barcelona, Spain. ISNI: 0000 0000 9635 9413. GRID: grid.410458.c FAU - Hodiamont, C J AU - Hodiamont CJ AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Juffermans, N P AU - Juffermans NP AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Janssen, J M AU - Janssen JM AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Bouman, C S AU - Bouman CS AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Mathôt, R A AU - Mathôt RA AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - De Jong, M D AU - De Jong MD AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Hest, R M AU - Van Hest RM AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Payne, L AU - Payne L AD - Maine Medical Center, Portland, USA. GRID: grid.240160.1 FAU - Fraser, G L AU - Fraser GL AD - Maine Medical Center, Portland, USA. GRID: grid.240160.1 FAU - Tudor, B AU - Tudor B AD - Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. GRID: grid.22937.3d FAU - Lahner, M AU - Lahner M AD - Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. GRID: grid.22937.3d FAU - Roth, G AU - Roth G AD - Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. GRID: grid.22937.3d FAU - Krenn, C AU - Krenn C AD - Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. GRID: grid.22937.3d FAU - Talaie, H AU - Talaie H AD - Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. GRID: grid.411600.2 FAU - Jault, P AU - Jault P AD - HIA Percy, Clamart, France. ISNI: 0000 0004 1795 3756. GRID: grid.414028.b FAU - Gabard, J AU - Gabard J AD - Pherecydes Pharma, Romainville, France FAU - Leclerc, T AU - Leclerc T AD - HIA Percy, Clamart, France. ISNI: 0000 0004 1795 3756. GRID: grid.414028.b FAU - Jennes, S AU - Jennes S AD - Hôpital Reine Astrid, Brussels, Belgium FAU - Que, Y AU - Que Y AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Rousseau, A AU - Rousseau A AD - CHU Liege, Liege, Belgium. ISNI: 0000 0000 8607 6858. GRID: grid.411374.4 FAU - Ravat, F AU - Ravat F AD - CH Saint Jospeh Saint Luc, Lyon, France FAU - Al-Dorzi, H AU - Al-Dorzi H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Eissa, A AU - Eissa A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Al-Harbi, S AU - Al-Harbi S AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Aldabbagh, T AU - Aldabbagh T AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Khan, R AU - Khan R AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Arabi, Y AU - Arabi Y AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Trifi, A AU - Trifi A AD - University hospital center of La Rabta, Tunis, Tunisia FAU - Abdellatif., S AU - Abdellatif. S AD - University hospital center of La Rabta, Tunis, Tunisia FAU - Daly, F AU - Daly F AD - University hospital center of La Rabta, Tunis, Tunisia FAU - Nasri, R AU - Nasri R AD - University hospital center of La Rabta, Tunis, Tunisia FAU - Ben Lakhal, S AU - Ben Lakhal S AD - University hospital center of La Rabta, Tunis, Tunisia FAU - Paramba, F AU - Paramba F AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Purayil, N AU - Purayil N AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Naushad, V AU - Naushad V AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Mohammad, O AU - Mohammad O AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Negi, V AU - Negi V AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Chandra, P AU - Chandra P AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Kleinsasser, A AU - Kleinsasser A AD - MUI, Innsbruck, Austria. ISNI: 0000 0000 8853 2677. GRID: grid.5361.1 FAU - Witrz, M R AU - Witrz MR AD - Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Buchner-Doeven, J F AU - Buchner-Doeven JF AD - Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Tuip-de Boer, A M AU - Tuip-de Boer AM AD - Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Goslings, J C AU - Goslings JC AD - Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Juffermans, N P AU - Juffermans NP AD - Academic Medical Centre, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Hezel, M AU - Van Hezel M AD - Academic Medical Center Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Straat, M AU - Straat M AD - Academic Medical Center Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Boing, A AU - Boing A AD - Academic Medical Center Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Bruggen, R AU - Van Bruggen R AD - Sanquin, Amsterdam, Netherlands. ISNI: 0000 0001 2234 6887. GRID: grid.417732.4 FAU - Juffermans, N AU - Juffermans N AD - Academic Medical Center Amsterdam, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Markopoulou, D AU - Markopoulou D AD - KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 FAU - Venetsanou, K AU - Venetsanou K AD - KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 FAU - Kaldis, V AU - Kaldis V AD - KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 FAU - Koutete, D AU - Koutete D AD - KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 FAU - Chroni, D AU - Chroni D AD - KAT Hospital Athens, Kifisia, Greece. ISNI: 0000 0004 0622 8129. GRID: grid.415070.7 FAU - Alamanos, I AU - Alamanos I AD - ICU-B, KAT Hospital Kifisia, Athens, Greece FAU - Koch, L AU - Koch L AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Jancik, J AU - Jancik J AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Rhodes, H AU - Rhodes H AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Walter, E AU - Walter E AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Maekawa, K AU - Maekawa K AD - Hokkaido University Hospital, Sapporo, Japan. ISNI: 0000 0004 0378 6088. GRID: grid.412167.7 FAU - Hayakawa, M AU - Hayakawa M AD - Hokkaido University Hospital, Sapporo, Japan. ISNI: 0000 0004 0378 6088. GRID: grid.412167.7 FAU - Kushimoto, S AU - Kushimoto S AD - Tohoku University Graduate School of Medicine, Sendai, Japan. ISNI: 0000 0001 2248 6943. GRID: grid.69566.3a FAU - Shiraishi, A AU - Shiraishi A AD - Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan. GRID: grid.474906.8 FAU - Kato, H AU - Kato H AD - National Hospital Organization Disaster Medical Center, Tokyo, Japan. ISNI: 0000 0004 0569 9594. GRID: grid.416797.a FAU - Sasaki, J AU - Sasaki J AD - Keio University School of Medicine, Tokyo, Japan. ISNI: 0000 0004 1936 9959. GRID: grid.26091.3c FAU - Ogura, H AU - Ogura H AD - Osaka University Graduate School of Medicine, Osaka, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Matauoka, T AU - Matauoka T AD - Rinku General Medical Center, Osaka, Japan FAU - Uejima, T AU - Uejima T AD - Kinki University Faculty of Medicine, Osaka, Japan. ISNI: 0000 0004 1936 9967. GRID: grid.258622.9 FAU - Morimura, N AU - Morimura N AD - Yokohama City University Graduate School of Medicine, Yokohama, Japan. ISNI: 0000 0001 1033 6139. GRID: grid.268441.d FAU - Ishikura, H AU - Ishikura H AD - Faculty of Medicine, Fukuoka University, Fukuoka, Japan. ISNI: 0000 0001 0672 2176. GRID: grid.411497.e FAU - Hagiwara, A AU - Hagiwara A AD - National Center For Global Health and Medicine, Tokyo, Japan. ISNI: 0000 0004 0489 0290. GRID: grid.45203.30 FAU - Takeda, M AU - Takeda M AD - Tokyo Women’s Medical University, Tokyo, Japan. ISNI: 0000 0001 0720 6587. GRID: grid.410818.4 FAU - Tarabrin, O AU - Tarabrin O AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Shcherbakow, S AU - Shcherbakow S AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Gavrychenko, D AU - Gavrychenko D AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Mazurenko, G AU - Mazurenko G AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Ivanova, V AU - Ivanova V AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Chystikov, O AU - Chystikov O AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Plourde, C AU - Plourde C AD - Hopital Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Lessard, J AU - Lessard J AD - Hopital Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Chauny, J AU - Chauny J FAU - Daoust, R AU - Daoust R AD - Hopital Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Shcherbakow, S AU - Shcherbakow S AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Tarabrin, O AU - Tarabrin O AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Gavrychenko, D AU - Gavrychenko D AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Mazurenko, G AU - Mazurenko G AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Chystikov, O AU - Chystikov O AD - Odessa National Medical University, Odessa, Ukraine. GRID: grid.445907.b FAU - Vakalos, A AU - Vakalos A AD - Xanthi General Hospital, Xanth, Greece. GRID: grid.414012.2 FAU - Avramidis, V AU - Avramidis V AD - Xanthi General Hospital, Xanth, Greece. GRID: grid.414012.2 FAU - Kropman, L AU - Kropman L AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - In het Panhuis, L AU - In het Panhuis L AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Konings, J AU - Konings J AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Huskens, D AU - Huskens D AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Schurgers, E AU - Schurgers E AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Roest, M AU - Roest M AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - De Laat, B AU - De Laat B AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Lance, M AU - Lance M AD - Maastricht UMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Durila, M AU - Durila M AD - Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. ISNI: 0000 0004 0611 0905. GRID: grid.412826.b FAU - Lukas, P AU - Lukas P AD - Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. ISNI: 0000 0004 0611 0905. GRID: grid.412826.b FAU - Astraverkhava, M AU - Astraverkhava M AD - Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. ISNI: 0000 0004 0611 0905. GRID: grid.412826.b FAU - Jonas, J AU - Jonas J AD - Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic. ISNI: 0000 0004 0611 0905. GRID: grid.412826.b FAU - Budnik, I AU - Budnik I AD - Sechenov First Moscow Stat Medical University, Moscow, Russia FAU - Shenkman, B AU - Shenkman B AD - Sheba Medical Center, Tel-Hashomer, Israel. ISNI: 0000 0001 2107 2845. GRID: grid.413795.d FAU - Hayami, H AU - Hayami H AD - Yokohama Municipal Citizen’s Hospital, Yokohama, Japan. ISNI: 0000 0004 0377 5418. GRID: grid.417366.1 FAU - Koide, Y AU - Koide Y AD - Hayama Heart Center, Hayama, Japan FAU - Goto, T AU - Goto T AD - Yokohama City University Hospital, Yokohama, Japan. ISNI: 0000 0004 1767 0473. GRID: grid.470126.6 FAU - Iqbal, R AU - Iqbal R AD - Institute of Ageing and Chronic Disease, Liverpool, UK FAU - Alhamdi, Y AU - Alhamdi Y AD - Institute of Infection and Global Health, Liverpool, UK FAU - Venugopal, N AU - Venugopal N AD - Institute of Ageing and Chronic Disease, Liverpool, UK FAU - Abrams, S AU - Abrams S AD - Institute of Infection and Global Health, Liverpool, UK FAU - Downey, C AU - Downey C AD - Department of Haematology, Royal Liverpool University Hospital (RLUH), Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Toh, C H AU - Toh CH AD - Institute of Infection and Global Health, Liverpool, UK FAU - Welters, I D AU - Welters ID AD - Institute of Ageing and Chronic Disease, Liverpool, UK FAU - Bombay, V B AU - Bombay VB AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Chauny, J M AU - Chauny JM AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Daoust, R D AU - Daoust RD AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Lessard, J L AU - Lessard JL AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Marquis, M M AU - Marquis MM AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Paquet, J P AU - Paquet JP AD - Hôpital du Sacré-Coeur de Montréal, Montreal, Canada. ISNI: 0000 0001 2160 7387. GRID: grid.414056.2 FAU - Siemens, K AU - Siemens K AD - Evelina London Children’s Hospital, London, UK FAU - Sangaran, D AU - Sangaran D AD - Evelina London Children’s Hospital, London, UK FAU - Hunt, B J AU - Hunt BJ AD - St Thomas Hospital, London, UK. GRID: grid.425213.3 FAU - Durward, A AU - Durward A AD - Evelina London Children’s Hospital, London, UK FAU - Nyman, A AU - Nyman A AD - Evelina London Children’s Hospital, London, UK FAU - Murdoch, I A AU - Murdoch IA AD - Evelina London Children’s Hospital, London, UK FAU - Tibby, S M AU - Tibby SM AD - Evelina London Children’s Hospital, London, UK FAU - Ampatzidou, F AU - Ampatzidou F AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Moisidou, D AU - Moisidou D AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Dalampini, E AU - Dalampini E AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Nastou, M AU - Nastou M AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Vasilarou, E AU - Vasilarou E AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Kalaizi, V AU - Kalaizi V AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Chatzikostenoglou, H AU - Chatzikostenoglou H AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Drossos, G AU - Drossos G AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Spadaro, S AU - Spadaro S AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Fogagnolo, A AU - Fogagnolo A AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Fiore, T AU - Fiore T AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Schiavi, A AU - Schiavi A AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Fontana, V AU - Fontana V AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Taccone, F AU - Taccone F AD - Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, Bruxelles, Belgium FAU - Volta, C AU - Volta C AD - Intensive Care Unit, University of Ferrara, Italy, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Chochliourou, E AU - Chochliourou E AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Volakli, E AU - Volakli E AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Violaki, A AU - Violaki A AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Samkinidou, E AU - Samkinidou E AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Evlavis, G AU - Evlavis G AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Panagiotidou, V AU - Panagiotidou V AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Sdougka, M AU - Sdougka M AD - Hippokration General Hospital Thessaloniki, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Mothukuri, R AU - Mothukuri R AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Battle, C AU - Battle C AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Guy, K AU - Guy K AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Mills, G AU - Mills G AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Evans, P AU - Evans P AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Wijesuriya, J AU - Wijesuriya J AD - Central London School of Anaesthesia and Intensive Care Medicine, London, UK FAU - Keogh, S AU - Keogh S AD - University of the Sunshine Coast, Maroochydore, Australia. ISNI: 0000 0001 1555 3415. GRID: grid.1034.6 FAU - Docherty, A AU - Docherty A AD - University of Edinburgh, Edinburgh, UK. ISNI: 0000 0004 1936 7988. GRID: grid.4305.2 FAU - O’Donnell, R AU - O’Donnell R AD - University of Edinburgh, Edinburgh, UK. ISNI: 0000 0004 1936 7988. GRID: grid.4305.2 FAU - Brunskill, S AU - Brunskill S AD - John Radcliffe Hospital, Oxford, UK. ISNI: 0000 0001 2306 7492. GRID: grid.8348.7 FAU - Trivella, M AU - Trivella M AD - John Radcliffe Hospital, Oxford, UK. ISNI: 0000 0001 2306 7492. GRID: grid.8348.7 FAU - Doree, C AU - Doree C AD - John Radcliffe Hospital, Oxford, UK. ISNI: 0000 0001 2306 7492. GRID: grid.8348.7 FAU - Holst, L AU - Holst L AD - Copenhagen University Hospital, Copenhagen, Denmark. ISNI: 0000 0004 0646 7373. GRID: grid.4973.9 FAU - Parker, M AU - Parker M AD - Peterborough NHS Trust, Peterborough, UK FAU - Gregersen, M AU - Gregersen M AD - Aarhus University, Aarhus, Denmark. ISNI: 0000 0001 1956 2722. GRID: grid.7048.b FAU - Almeida, J AU - Almeida J AD - Hospital de Sao Paulo, Sao Paulo, Brazil. GRID: grid.413463.7 FAU - Walsh, T AU - Walsh T AD - University of Edinburgh, Edinburgh, UK. ISNI: 0000 0004 1936 7988. GRID: grid.4305.2 FAU - Stanworth, S AU - Stanworth S AD - John Radcliffe Hospital, Oxford, UK. ISNI: 0000 0001 2306 7492. GRID: grid.8348.7 FAU - Moravcova, S AU - Moravcova S AD - Royal Brompton & Harefield NHS Trust, London, UK. ISNI: 0000 0004 0581 2008. GRID: grid.451052.7 FAU - Mansell, J AU - Mansell J AD - Barts Heart Centre, London, UK FAU - Rogers, A AU - Rogers A AD - Barts Heart Centre, London, UK FAU - Smith, R A AU - Smith RA AD - Barts Heart Centre, London, UK FAU - Hamilton-Davies, C AU - Hamilton-Davies C AD - Barts Heart Centre, London, UK FAU - Omar, A AU - Omar A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Allam, M AU - Allam M AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Bilala, O AU - Bilala O AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Kindawi, A AU - Kindawi A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Ewila, H AU - Ewila H AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Ampatzidou, F AU - Ampatzidou F AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Moisidou, D AU - Moisidou D AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Nastou, M AU - Nastou M AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Dalampini, E AU - Dalampini E AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Malamas, A AU - Malamas A AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Vasilarou, E AU - Vasilarou E AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Drossos, G AU - Drossos G AD - G.Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Ferreira, G AU - Ferreira G AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Caldas, J AU - Caldas J AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Fukushima, J AU - Fukushima J AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Osawa, E A AU - Osawa EA AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Arita, E AU - Arita E AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Camara, L AU - Camara L AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Zeferino, S AU - Zeferino S AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Jardim, J AU - Jardim J AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Gaioto, F AU - Gaioto F AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Dallan, L AU - Dallan L AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Jatene, F B AU - Jatene FB AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Kalil Filho, R AU - Kalil Filho R AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Galas, F AU - Galas F AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Hajjar, L A AU - Hajjar LA AD - University of Sao Paulo, Brazi, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Mitaka, C AU - Mitaka C AD - Juntendo University Hospital, Tokyo, Japan. GRID: grid.411966.d FAU - Ohnuma, T AU - Ohnuma T AD - Saitama Medical Center, Jichi Medical University, Saitama, Japan. ISNI: 0000000123090000. GRID: grid.410804.9 FAU - Murayama, T AU - Murayama T FAU - Kunimoto, F AU - Kunimoto F AD - Gunma University Hospital, Maebashi, Japan. ISNI: 0000 0004 0595 7039. GRID: grid.411887.3 FAU - Nagashima, M AU - Nagashima M AD - Yokohama City Minato Red Cross Hospital, Yokohama, Japan FAU - Takei, T AU - Takei T AD - Yokohama City Minato Red Cross Hospital, Yokohama, Japan FAU - Tomita, M AU - Tomita M AD - Tokyo Medical and Dental University Hospital of Medicine, Tokyo, Japan. GRID: grid.474906.8 FAU - Omar, A AU - Omar A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Mahmoud, K AU - Mahmoud K AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Hanoura, S AU - Hanoura S AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Sudarsanan, S AU - Sudarsanan S AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Sivadasan, P AU - Sivadasan P AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Othamn, H AU - Othamn H AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Shouman, Y AU - Shouman Y AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Singh, R AU - Singh R AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Al Khulaifi, A AU - Al Khulaifi A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Mandel, I AU - Mandel I AD - Research Institution for Cardiology, Tomsk, Russia FAU - Mikheev, S AU - Mikheev S AD - Research Institution for Cardiology, Tomsk, Russia FAU - Suhodolo, I AU - Suhodolo I AD - Siberian State Medical University, Tomsk, Russia. ISNI: 0000 0001 0027 1685. GRID: grid.412593.8 FAU - Kiselev, V AU - Kiselev V AD - Research Institution for Cardiology, Tomsk, Russia FAU - Svirko, Y AU - Svirko Y AD - Research Institution for Cardiology, Tomsk, Russia FAU - Podoksenov, Y AU - Podoksenov Y AD - Research Institution for Cardiology, Tomsk, Russia FAU - Jenkins, S A AU - Jenkins SA AD - The Hillingdon Hospitals NHS Foundation Trust, Middlesex, UK. ISNI: 0000 0004 0476 7073. GRID: grid.440199.1 FAU - Griffin, R AU - Griffin R AD - The Hillingdon Hospitals NHS Foundation Trust, Middlesex, UK. ISNI: 0000 0004 0476 7073. GRID: grid.440199.1 FAU - Tovar Doncel, M S AU - Tovar Doncel MS AD - University Hospital Rio Hortega, Valladolid, Spain. ISNI: 0000 0001 1842 3755. GRID: grid.411280.e FAU - Lima, A AU - Lima A AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Aldecoa, C AU - Aldecoa C AD - University Hospital Rio Hortega, Valladolid, Spain. ISNI: 0000 0001 1842 3755. GRID: grid.411280.e FAU - Ince, C AU - Ince C AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Taha, A AU - Taha A AD - Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 FAU - Shafie, A AU - Shafie A AD - Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 FAU - Mostafa, M AU - Mostafa M AD - Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 FAU - Syed, N AU - Syed N AD - Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 FAU - Hon, H AU - Hon H AD - Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. ISNI: 0000 0004 1773 3278. GRID: grid.415670.1 FAU - Righetti, F AU - Righetti F AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Colombaroli, E AU - Colombaroli E AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Castellano, G AU - Castellano G AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Righetti, F AU - Righetti F AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Colombaroli, E AU - Colombaroli E AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Hravnak, M AU - Hravnak M AD - University of Pittsburgh, Pittsburgh, USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d FAU - Chen, L C AU - Chen LC AD - Carnegie Mellon University, Pittsburgh, USA. ISNI: 0000 0001 2097 0344. GRID: grid.147455.6 FAU - Dubrawski, A D AU - Dubrawski AD AD - Carnegie Mellon University, Pittsburgh, USA. ISNI: 0000 0001 2097 0344. GRID: grid.147455.6 FAU - Clermont, G C AU - Clermont GC AD - University of Pittsburgh, Pittsburgh, USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d FAU - Pinsky, M R AU - Pinsky MR AD - University of Pittsburgh, Pittsburgh, USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d FAU - Gonzalez, S AU - Gonzalez S AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Macias, D AU - Macias D AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Acosta, J AU - Acosta J AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Jimenez, P AU - Jimenez P AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Loza, A AU - Loza A AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Lesmes, A AU - Lesmes A AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Lucena, F AU - Lucena F AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Leon, C AU - Leon C AD - Valme University Hospital, Seville, Spain. ISNI: 0000 0004 1768 1690. GRID: grid.412800.f FAU - Tovar Doncel, M S AU - Tovar Doncel MS AD - University Hospital Rio Hortega, Valladolid, Spain. ISNI: 0000 0001 1842 3755. GRID: grid.411280.e FAU - Ince, C AU - Ince C AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Aldecoa, C AU - Aldecoa C AD - University Hospital Rio Hortega, Valladolid, Spain. ISNI: 0000 0001 1842 3755. GRID: grid.411280.e FAU - Lima, A AU - Lima A AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Bastide, M AU - Bastide M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Richecoeur, J AU - Richecoeur J AD - CH Beauvais, Beauvais, France FAU - Frenoy, E AU - Frenoy E AD - Réanimation polyvalente, Le Havre, France FAU - Lemaire, C AU - Lemaire C AD - CH Roubaix, Roubaix, France. ISNI: 0000 0004 0608 7784. GRID: grid.477297.8 FAU - Sauneuf, B AU - Sauneuf B AD - CH Cotentin, Cherbourg, France FAU - Tamion, F AU - Tamion F AD - CHU Rouen, Rouen, France. GRID: grid.41724.34 FAU - Nseir, S AU - Nseir S AD - CHU Lille, Lille, France. ISNI: 0000 0004 0471 8845. GRID: grid.410463.4 FAU - Du Cheyron, D AU - Du Cheyron D AD - CHU Caen, Caen, France. ISNI: 0000 0004 0472 0160. GRID: grid.411149.8 FAU - Dupont, H AU - Dupont H AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Maizel, J AU - Maizel J AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Shaban, M AU - Shaban M AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Kolko, R AU - Kolko R AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Salahuddin, N AU - Salahuddin N AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Sharshir, M AU - Sharshir M AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - AbuRageila, M AU - AbuRageila M AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - AlHussain, A AU - AlHussain A AD - King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Mercado, P AU - Mercado P AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Maizel, J AU - Maizel J AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Kontar, L AU - Kontar L AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Titeca, D AU - Titeca D AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Brazier, F AU - Brazier F AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Riviere, A AU - Riviere A AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Joris, M AU - Joris M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Soupison, T AU - Soupison T AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - De Cagny, B AU - De Cagny B AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Slama, M AU - Slama M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Wagner, J AU - Wagner J AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Körner, A AU - Körner A AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Kubik, M AU - Kubik M AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Kluge, S AU - Kluge S AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Reuter, D AU - Reuter D AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Saugel, B AU - Saugel B AD - University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Colombaroli, E AU - Colombaroli E AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Righetti, F AU - Righetti F AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Castellano, G AU - Castellano G AD - Intensive Care Unit, St. Boniface Hospital, Verona, Italy FAU - Tran, T AU - Tran T AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - De Bels, D AU - De Bels D AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Cudia, A AU - Cudia A AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Strachinaru, M AU - Strachinaru M AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Ghottignies, P AU - Ghottignies P AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Devriendt, J AU - Devriendt J AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Pierrakos, C AU - Pierrakos C AD - Brugmann Hospital, Brussels, Belgium. ISNI: 0000 0004 0469 8354. GRID: grid.411371.1 FAU - Martínez González, Ó AU - Martínez González Ó AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Blancas, R AU - Blancas R AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Luján, J AU - Luján J AD - Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain. ISNI: 0000 0004 1765 5855. GRID: grid.411338.c FAU - Ballesteros, D AU - Ballesteros D AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Martínez Díaz, C AU - Martínez Díaz C AD - Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain. ISNI: 0000 0004 1765 5855. GRID: grid.411338.c FAU - Núñez, A AU - Núñez A AD - Hospital Universitario de San Carlos, Madrid, Spain. ISNI: 0000 0001 0671 5785. GRID: grid.411068.a FAU - Martín Parra, C AU - Martín Parra C AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - López Matamala, B AU - López Matamala B AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Alonso Fernández, M AU - Alonso Fernández M AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Chana, M AU - Chana M AD - Hospital Universitario del Tajo, Aranjuez, Spain FAU - Huber, W AU - Huber W AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Eckmann, M AU - Eckmann M AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Elkmann, F AU - Elkmann F AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Gruber, A AU - Gruber A AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Klein, I AU - Klein I AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Schmid, R M AU - Schmid RM AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Lahmer, T AU - Lahmer T AD - Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. ISNI: 0000000123222966. GRID: grid.6936.a FAU - Moller, P W AU - Moller PW AD - Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 FAU - Sondergaard, S AU - Sondergaard S AD - Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden FAU - Jakob, S M AU - Jakob SM AD - Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 FAU - Takala, J AU - Takala J AD - Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 FAU - Berger, D AU - Berger D AD - Department of Intensive Care Medicine, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 FAU - Bastoni, D AU - Bastoni D AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Aya, H AU - Aya H AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Toscani, L AU - Toscani L AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Pigozzi, L AU - Pigozzi L AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Rhodes, A AU - Rhodes A AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Cecconi, M AU - Cecconi M AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Ostrowska, C AU - Ostrowska C AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Aya, H AU - Aya H AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Abbas, A AU - Abbas A AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Mellinghoff, J AU - Mellinghoff J AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Ryan, C AU - Ryan C AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Dawson, D AU - Dawson D AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Rhodes, A AU - Rhodes A AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Cecconi, M AU - Cecconi M AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Cronhjort, M AU - Cronhjort M AD - Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 FAU - Wall, O AU - Wall O AD - Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 FAU - Nyberg, E AU - Nyberg E AD - Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 FAU - Zeng, R AU - Zeng R AD - Wenzhou Medical University, Wenzhou, Zheijang China. ISNI: 0000 0001 0348 3990. GRID: grid.268099.c FAU - Svensen, C AU - Svensen C AD - Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 FAU - Mårtensson, J AU - Mårtensson J AD - Department of Intensive Care, Austin Hospital, Melbourne, VIC Australia. ISNI: 0000 0001 0162 7225. GRID: grid.414094.c FAU - Joelsson-Alm, E AU - Joelsson-Alm E AD - Karolinska Institutet, Stockholm, Sweden. ISNI: 0000 0004 1937 0626. GRID: grid.4714.6 FAU - Aguilar Arzapalo, M AU - Aguilar Arzapalo M AD - Hospital O’horan, Mérida, Mexico FAU - Barradas, L AU - Barradas L AD - Hospital O’horan, Mérida, Mexico FAU - Lopez, V AU - Lopez V AD - Hospital O’horan, Mérida, Mexico FAU - Cetina, M AU - Cetina M AD - Hospital O’horan, Mérida, Mexico FAU - Parenti, N AU - Parenti N AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Palazzi, C AU - Palazzi C AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Amidei, L A AU - Amidei LA AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Borrelli, F B AU - Borrelli FB AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Campanale, S C AU - Campanale SC AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Tagliazucchi, F T AU - Tagliazucchi FT AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Sedoni, G S AU - Sedoni GS AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Lucchesi, D L AU - Lucchesi DL AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Carella, E C AU - Carella EC AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Luciani, A L AU - Luciani AL AD - Policlinico Modena, Bologna, Italy. ISNI: 0000 0004 1769 5275. GRID: grid.413363.0 FAU - Mackovic, M AU - Mackovic M AD - Clinical Hospital Sveti Duh, Zagreb, Croatia FAU - Maric, N AU - Maric N AD - Clinical Hospital Sveti Duh, Zagreb, Croatia FAU - Bakula, M AU - Bakula M AD - Clinical Hospital Sveti Duh, Zagreb, Croatia FAU - Aya, H AU - Aya H AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Rhodes, A AU - Rhodes A AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Grounds, R M AU - Grounds RM AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Fletcher, N AU - Fletcher N AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Cecconi, M AU - Cecconi M AD - St George’s Healthcare NHS Trust, London, UK. GRID: grid.451349.e FAU - Avard, B AU - Avard B AD - The Canberra Hospital, Hughes, ACT Australia. ISNI: 0000 0000 9984 5644. GRID: grid.413314.0 FAU - Zhang, P AU - Zhang P AD - Australian National University Medical School, Canberra, Australia. ISNI: 0000 0001 2180 7477. GRID: grid.1001.0 FAU - Mezidi, M AU - Mezidi M AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Charbit, J AU - Charbit J AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Ould-Chikh, M AU - Ould-Chikh M AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Deras, P AU - Deras P AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Maury, C AU - Maury C AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Martinez, O AU - Martinez O AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Capdevila, X AU - Capdevila X AD - Lapeyronie University Hospital, Montpellier, France. ISNI: 0000 0004 0638 8990. GRID: grid.411572.4 FAU - Hou, P AU - Hou P AD - Brigham and Women’s Hospital, Boston, USA. ISNI: 0000 0004 0378 8294. GRID: grid.62560.37 FAU - Linde-Zwirble, W Z AU - Linde-Zwirble WZ AD - Trexin Medical, Chicago, USA FAU - Douglas, I D AU - Douglas ID AD - University of Colorado and Denver Health, Denver, USA. ISNI: 0000000107903411. GRID: grid.241116.1 FAU - Shapiro, N S AU - Shapiro NS AD - Beth Isreal Deaconess, Boston, USA FAU - Ben Souissi, A AU - Ben Souissi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mezghani, I AU - Mezghani I AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Ben Aicha, Y AU - Ben Aicha Y AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Kamoun, S AU - Kamoun S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Laribi, B AU - Laribi B AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Jeribi, B AU - Jeribi B AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Riahi, A AU - Riahi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mebazaa, M S AU - Mebazaa MS AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Pereira, C AU - Pereira C AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Antunes, R AU - Antunes R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Crivits, M AU - Crivits M AD - University Hospital, Ghent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Raes, M AU - Raes M AD - University Hospital, Ghent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Decruyenaere, J AU - Decruyenaere J AD - University Hospital, Ghent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Hoste, E AU - Hoste E AD - University Hospital, Ghent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Bagin, V AU - Bagin V AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Rudnov, V AU - Rudnov V AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Savitsky, A AU - Savitsky A AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Astafyeva, M AU - Astafyeva M AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Korobko, I AU - Korobko I AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Vein, V AU - Vein V AD - City Clinical Hospital 40, Yekaterinburg, Russia FAU - Kampmeier, T AU - Kampmeier T AD - University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Arnemann, P AU - Arnemann P AD - University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Hessler, M AU - Hessler M AD - University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Wald, A AU - Wald A AD - Marienhospital Osnabrück, Osnabrück, Germany FAU - Bockbreder, K AU - Bockbreder K AD - Charité, University of Berlin, Berlin, Germany FAU - Morelli, A AU - Morelli A AD - Sapienza University of Rome, Rome, Italy. GRID: grid.7841.a FAU - Van Aken, H AU - Van Aken H AD - University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Rehberg, S AU - Rehberg S AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Ertmer, C AU - Ertmer C AD - University Hospital Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Arnemann, P AU - Arnemann P AD - University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Hessler, M AU - Hessler M AD - University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Kampmeier, T AU - Kampmeier T AD - University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Rehberg, S AU - Rehberg S AD - University Hospital of Greifswald, Greifswald, Germany. ISNI: 0000 0000 9116 8976. GRID: grid.412469.c FAU - Van Aken, H AU - Van Aken H AD - University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Ince, C AU - Ince C AD - Erasmus MC University Hospital Rotterdam, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Ertmer, C AU - Ertmer C AD - University Hospital of Muenster, Muenster, Germany. ISNI: 0000 0004 0551 4246. GRID: grid.16149.3b FAU - Reddy, S AU - Reddy S AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Bailey, M AU - Bailey M AD - Monash University, Melbourne, Australia. ISNI: 0000 0004 1936 7857. GRID: grid.1002.3 FAU - Beasley, R AU - Beasley R AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Bellomo, R AU - Bellomo R AD - Austin Hospital, Melbourne, Australia. ISNI: 0000 0001 0162 7225. GRID: grid.414094.c FAU - Mackle, D AU - Mackle D AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Psirides, A AU - Psirides A AD - Wellington Regional Hospital, Wellington, New Zealand. ISNI: 0000 0000 8862 6892. GRID: grid.416979.4 FAU - Young, P AU - Young P AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Reddy, S AU - Reddy S AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Bailey, M AU - Bailey M AD - Australian and New Zealand Intensive Care Research Centre, Melbourne, Australia FAU - Beasley, R AU - Beasley R AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Bellomo, R AU - Bellomo R AD - Austin Hospital, Melbourne, Australia. ISNI: 0000 0001 0162 7225. GRID: grid.414094.c FAU - Mackle, D AU - Mackle D AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Young, P AU - Young P AD - Medical Research Institute of New Zealand, Wellington, New Zealand. ISNI: 0000 0004 0445 6830. GRID: grid.415117.7 FAU - Venkatesh, H AU - Venkatesh H AD - Princess of Wales Hospital, Bridgend, UK. ISNI: 0000 0004 0648 9337. GRID: grid.415249.f FAU - Ramachandran, S AU - Ramachandran S AD - Imperial College London, London, UK. ISNI: 0000 0001 2113 8111. GRID: grid.7445.2 FAU - Basu, A AU - Basu A AD - Glan Clwyd Hospital, Bodelwyddan, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 FAU - Nair, H AU - Nair H AD - Glan Clwyd Hospital, Bodelwyddan, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 FAU - Egan, S AU - Egan S AD - University Hospital Galway, Galway, Ireland. ISNI: 0000 0004 0617 9371. GRID: grid.412440.7 FAU - Bates, J AU - Bates J AD - University Hospital Galway, Galway, Ireland. ISNI: 0000 0004 0617 9371. GRID: grid.412440.7 FAU - Oliveira, S AU - Oliveira S AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Rangel Neto, N R AU - Rangel Neto NR AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Reis, F Q AU - Reis FQ AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Lee, C P AU - Lee CP AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Lin, X L AU - Lin XL AD - National Neuroscience Institute, Singapore, Singapore. ISNI: 0000 0004 0636 696X. GRID: grid.276809.2 FAU - Choong, C AU - Choong C AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Eu, K M AU - Eu KM AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Sim, W Y AU - Sim WY AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Tee, K S AU - Tee KS AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Pau, J AU - Pau J AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Abisheganaden, J AU - Abisheganaden J AD - Tan Tock Seng Hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Maas, K AU - Maas K AD - Erasmus Medical Centre, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - De Geus, H AU - De Geus H AD - Erasmus Medical Centre, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Lafuente, E AU - Lafuente E AD - Centro Hospitalar Tamega e Sousa, Penafiel, Portugal. GRID: grid.466592.a FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Moura, J AU - Moura J AD - Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal FAU - Antunes, R AU - Antunes R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Doris, T E AU - Doris TE AD - South Tees NHS Trust, Middlesbrough, UK FAU - Monkhouse, D AU - Monkhouse D AD - South Tees NHS Trust, Middlesbrough, UK FAU - Shipley, T AU - Shipley T AD - South Tees NHS Trust, Middlesbrough, UK FAU - Kardasz, S AU - Kardasz S AD - South Tees NHS Trust, Middlesbrough, UK FAU - Gonzalez, I AU - Gonzalez I AD - South Tees NHS Trust, Middlesbrough, UK FAU - Stads, S AU - Stads S AD - Ikazia Hospital, Rotterdam, Netherlands. ISNI: 0000 0004 0568 7120. GRID: grid.414565.7 FAU - Groeneveld, A J AU - Groeneveld AJ AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Elsayed, I AU - Elsayed I AD - Sheffiled Teaching Hospitals, Sheffield, UK FAU - Ward, N AU - Ward N AD - Sheffiled Teaching Hospitals, Sheffield, UK FAU - Tridente, A AU - Tridente A AD - Whiston Hospital, St Helens & Knowsley, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Raithatha, A AU - Raithatha A AD - Sheffiled Teaching Hospitals, Sheffield, UK FAU - Steuber, A AU - Steuber A AD - University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d FAU - Pelletier, C AU - Pelletier C AD - University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d FAU - Schroeder, S AU - Schroeder S AD - University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d FAU - Michael, E AU - Michael E AD - University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d FAU - Slowinski, T AU - Slowinski T AD - Charite University Hospital, Berlin, Germany. ISNI: 0000 0001 2218 4662. GRID: grid.6363.0 FAU - Kindgen-Milles, D AU - Kindgen-Milles D AD - University Hospital Duesseldorf, Düsseldorf, Germany. ISNI: 0000 0000 8922 7789. GRID: grid.14778.3d FAU - Ghabina, S AU - Ghabina S AD - Royal London Hospital, London, UK. ISNI: 0000 0001 0738 5466. GRID: grid.416041.6 FAU - Turani, F AU - Turani F AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Belli, A AU - Belli A AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Busatti, S AU - Busatti S AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Barettin, G AU - Barettin G AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Candidi, F AU - Candidi F AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Gargano, F AU - Gargano F AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Barchetta, R AU - Barchetta R AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Falco, M AU - Falco M AD - Aurelia and European Hospital, Rome, Italy. GRID: grid.414645.6 FAU - Demirkiran, O AU - Demirkiran O AD - Istanbul University Cerrahpasa Medical School, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Kosuk, M AU - Kosuk M AD - Istanbul University Cerrahpasa Medical School, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Bozbay, S AU - Bozbay S AD - Istanbul University Cerrahpasa Medical School, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Weber, V AU - Weber V AD - Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 FAU - Hartmann, J AU - Hartmann J AD - Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 FAU - Harm, S AU - Harm S AD - Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 FAU - Linsberger, I AU - Linsberger I AD - Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 FAU - Eichhorn, T AU - Eichhorn T AD - Danube University Krems, Krems, Austria. ISNI: 0000 0001 2108 5830. GRID: grid.15462.34 FAU - Valicek, G AU - Valicek G AD - University Hospital St. Poelten, St. Poelten, Austria FAU - Miestinger, G AU - Miestinger G AD - University Hospital St. Poelten, St. Poelten, Austria FAU - Hoermann, C AU - Hoermann C AD - University Hospital St. Poelten, St. Poelten, Austria FAU - Faenza, S AU - Faenza S AD - Teaching Hospital Policlinico S.Orsola-Malpighi, Bologna, Italy. GRID: grid.412311.4 FAU - Ricci, D AU - Ricci D AD - Department of Nephrology, Dialysis, Hypertension, Bologna, Italy FAU - Mancini, E AU - Mancini E AD - Department of Nephrology, Dialysis, Hypertension, Bologna, Italy FAU - Gemelli, C AU - Gemelli C AD - Science and Technology Park for Medicine, Mirandola, Italy FAU - Cuoghi, A AU - Cuoghi A AD - Science and Technology Park for Medicine, Mirandola, Italy FAU - Magnani, S AU - Magnani S AD - Aferetica, Bologna, Italy FAU - Atti, M AU - Atti M AD - Aferetica, Bologna, Italy FAU - Laddomada, T AU - Laddomada T AD - San Marco Hospital, Zingonia, Italy FAU - Doronzio, A AU - Doronzio A AD - San Marco Hospital, Zingonia, Italy FAU - Balicco, B AU - Balicco B AD - San Marco Hospital, Zingonia, Italy FAU - Gruda, M C AU - Gruda MC AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - O’Sullivan, P AU - O’Sullivan P AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Dan, V P AU - Dan VP AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Guliashvili, T AU - Guliashvili T AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Scheirer, A AU - Scheirer A AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Golobish, T D AU - Golobish TD AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Capponi, V J AU - Capponi VJ AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Chan, P P AU - Chan PP AD - CytoSorbents, Monmouth Junction, USA. GRID: grid.428484.6 FAU - Kogelmann, K AU - Kogelmann K AD - Klinikum Emden, Emden, Germany FAU - Drüner, M AU - Drüner M AD - Klinikum Emden, Emden, Germany FAU - Jarczak, D AU - Jarczak D AD - University Hospital Eppendorf, Hamburg, Germany. ISNI: 0000 0001 2180 3484. GRID: grid.13648.38 FAU - Turani, F AU - Turani F AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Belli, A B AU - Belli AB AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Martni, S M AU - Martni SM AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Cotticelli, V C AU - Cotticelli VC AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Mounajergi, F AU - Mounajergi F AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Barchetta, R AU - Barchetta R AD - Aurelia Hospital /European Hospital, Rome, Italy. GRID: grid.414077.1 FAU - Morimoto, S AU - Morimoto S AD - Fukuoka University hospital, Fukuoka, Japan. ISNI: 0000 0004 0594 9821. GRID: grid.411556.2 FAU - Ishikura, H AU - Ishikura H AD - Fukuoka University hospital, Fukuoka, Japan. ISNI: 0000 0004 0594 9821. GRID: grid.411556.2 FAU - Hussain, I AU - Hussain I AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Salahuddin, N AU - Salahuddin N AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Nadeem, A AU - Nadeem A AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Ghorab, K AU - Ghorab K AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Maghrabi, K AU - Maghrabi K AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Kloesel, S K AU - Kloesel SK AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Goldfuss, C AU - Goldfuss C AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Stieglitz, A AU - Stieglitz A AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Stieglitz, A S AU - Stieglitz AS AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Krstevska, L AU - Krstevska L AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Albuszies, G AU - Albuszies G AD - GPR Klinikum Ruesselsheim, Ruesselsheim, Hessen Germany FAU - Aguilar Arzapalo, M AU - Aguilar Arzapalo M AD - Hospital O’horan, Mérida, Mexico FAU - Barradas, L AU - Barradas L AD - Hospital O’horan, Mérida, Mexico FAU - Lopez, V AU - Lopez V AD - Hospital O’horan, Mérida, Mexico FAU - Escalante, A AU - Escalante A AD - Hospital O’horan, Mérida, Mexico FAU - Jimmy, G AU - Jimmy G AD - Hospital O’horan, Mérida, Mexico FAU - Cetina, M AU - Cetina M AD - Hospital O’horan, Mérida, Mexico FAU - Izawa, J AU - Izawa J AD - Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Iwami, T AU - Iwami T AD - Kyoto University, Kyoto, Japan. ISNI: 0000 0004 0372 2033. GRID: grid.258799.8 FAU - Uchino, S AU - Uchino S AD - Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Takinami, M AU - Takinami M AD - Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Kitamura, T AU - Kitamura T AD - Osaka University, Osaka, Japan. ISNI: 0000 0004 0373 3971. GRID: grid.136593.b FAU - Kawamura, T AU - Kawamura T AD - Kyoto University, Kyoto, Japan. ISNI: 0000 0004 0372 2033. GRID: grid.258799.8 FAU - Powell-Tuck, J G AU - Powell-Tuck JG AD - Guy’s & St Thomas’ NHS Foundation Trust, London, UK. GRID: grid.420545.2 FAU - Crichton, S AU - Crichton S AD - King’s College, London, UK. ISNI: 0000 0001 2322 6764. GRID: grid.13097.3c FAU - Raimundo, M AU - Raimundo M AD - Hospital de Santa Maria, Lisbon, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 FAU - Camporota, L AU - Camporota L AD - Guy’s & St Thomas’ NHS Foundation Trust, London, UK. GRID: grid.420545.2 FAU - Wyncoll, D AU - Wyncoll D AD - Guy’s & St Thomas’ NHS Foundation Trust, London, UK. GRID: grid.420545.2 FAU - Ostermann, M AU - Ostermann M AD - Guy’s & St Thomas’ NHS Foundation Trust, London, UK. GRID: grid.420545.2 FAU - Hana, A AU - Hana A AD - ErasmusMC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - De Geus, H R AU - De Geus HR AD - ErasmusMC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - De Geus, H R AU - De Geus HR AD - ErasmusMC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Hana, A AU - Hana A AD - ErasmusMC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Aydogdu, M AU - Aydogdu M AD - Gazi University Medical Faculty, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Boyaci, N AU - Boyaci N AD - Gazi University School of Medicine, Critical Care Fellowship Programme, Ankara, Turkey FAU - Yuksel, S AU - Yuksel S AD - Gazi University School of Medicine Biochemistry Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Gursel, G AU - Gursel G AD - Gazi University Medical Faculty, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Cayci Sivri, A B AU - Cayci Sivri AB AD - Gazi University School of Medicine Biochemistry Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Meza-Márquez, J AU - Meza-Márquez J AD - Fundación Clínica Medica Sur, Mexico City, Mexico FAU - Nava-López, J AU - Nava-López J AD - Fundación Clínica Medica Sur, Mexico City, Mexico FAU - Carrillo-Esper, R AU - Carrillo-Esper R AD - Fundación Clínica Medica Sur, Mexico City, Mexico FAU - Dardashti, A AU - Dardashti A AD - Lund University and Skane University Hospital, Lund, Sweden. GRID: grid.411843.b FAU - Grubb, A AU - Grubb A AD - Lund University and Skane University Hospital, Lund, Sweden. GRID: grid.411843.b FAU - Maizel, J AU - Maizel J AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Wetzstein, M AU - Wetzstein M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Titeca, D AU - Titeca D AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Kontar, L AU - Kontar L AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Brazier, F AU - Brazier F AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - De Cagny, B AU - De Cagny B AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Riviere, A AU - Riviere A AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Soupison, T AU - Soupison T AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Joris, M AU - Joris M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Slama, M AU - Slama M AD - Radboudumc, Nijmegen, Netherlands. ISNI: 0000 0004 0444 9382. GRID: grid.10417.33 FAU - Peters, E AU - Peters E FAU - Njimi, H AU - Njimi H AD - Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. ISNI: 0000 0001 2348 0746. GRID: grid.4989.c FAU - Pickkers, P AU - Pickkers P AD - Radboudumc, Nijmegen, Netherlands. ISNI: 0000 0004 0444 9382. GRID: grid.10417.33 FAU - Vincent, J L AU - Vincent JL AD - Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. ISNI: 0000 0001 2348 0746. GRID: grid.4989.c FAU - Waraich, M AU - Waraich M AD - The Royal Surrey County Hospital, Guildford, UK. ISNI: 0000 0004 0417 0648. GRID: grid.416224.7 FAU - Doyle, J AU - Doyle J AD - The Royal Surrey County Hospital, Guildford, UK. ISNI: 0000 0004 0417 0648. GRID: grid.416224.7 FAU - Samuels, T AU - Samuels T AD - The Royal Surrey County Hospital, Guildford, UK. ISNI: 0000 0004 0417 0648. GRID: grid.416224.7 FAU - Forni, L AU - Forni L AD - The Royal Surrey County Hospital, Guildford, UK. ISNI: 0000 0004 0417 0648. GRID: grid.416224.7 FAU - Desai, N AU - Desai N AD - Royal National Orthopaedic Hospital, Middlesex, UK. ISNI: 0000 0004 0417 7890. GRID: grid.416177.2 FAU - Baumber, R AU - Baumber R AD - Royal National Orthopaedic Hospital, Middlesex, UK. ISNI: 0000 0004 0417 7890. GRID: grid.416177.2 FAU - Gunning, P AU - Gunning P AD - Royal National Orthopaedic Hospital, Middlesex, UK. ISNI: 0000 0004 0417 7890. GRID: grid.416177.2 FAU - Sell, A AU - Sell A AD - Royal National Orthopaedic Hospital, Middlesex, UK. ISNI: 0000 0004 0417 7890. GRID: grid.416177.2 FAU - Lin, S AU - Lin S AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Torrence, H AU - Torrence H AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - O’Dwyer, M AU - O’Dwyer M AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Kirwan, C AU - Kirwan C AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Prowle, J AU - Prowle J AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Kim, T AU - Kim T AD - Asan medical center, Seoul, South Korea. ISNI: 0000 0001 0842 2126. GRID: grid.413967.e FAU - O’Connor, M E AU - O’Connor ME AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Hewson, R W AU - Hewson RW AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Kirwan, C J AU - Kirwan CJ AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Pearse, R M AU - Pearse RM AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Prowle, J AU - Prowle J AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Hanoura, S AU - Hanoura S AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Omar, A AU - Omar A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Othamn, H AU - Othamn H AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Sudarsanan, S AU - Sudarsanan S AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Allam, M AU - Allam M AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Maksoud, M AU - Maksoud M AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Singh, R AU - Singh R AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Al Khulaifi, A AU - Al Khulaifi A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - O’Connor, M E AU - O’Connor ME AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Hewson, R W AU - Hewson RW AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Kirwan, C J AU - Kirwan CJ AD - Barts Health NHS Trust, London, UK. ISNI: 0000 0001 0372 5777. GRID: grid.139534.9 FAU - Pearse, R M AU - Pearse RM AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Prowle, J AU - Prowle J AD - Queen Mary University of London, London, UK. ISNI: 0000 0001 2171 1133. GRID: grid.4868.2 FAU - Uzundere, O AU - Uzundere O AD - Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 FAU - Memis, D AU - Memis D AD - Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 FAU - Ýnal, M AU - Ýnal M AD - Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 FAU - Gultekin, A AU - Gultekin A AD - Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 FAU - Turan, N AU - Turan N AD - Trakya Univ, Edirne, Turkey. ISNI: 0000 0001 2342 6459. GRID: grid.411693.8 FAU - Aydin, M A AU - Aydin MA AD - General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 FAU - Basar, H AU - Basar H AD - AnkaraNKARA Research and Training Hospital, Ankara, Turkey FAU - Sencan, I AU - Sencan I AD - General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 FAU - Kapuagasi, A AU - Kapuagasi A AD - General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 FAU - Ozturk, M AU - Ozturk M AD - General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 FAU - Uzundurukan, Z AU - Uzundurukan Z AD - General Directorate of Health Services, Ministry of Health, Ankara, Turkey. GRID: grid.415700.7 FAU - Gokmen, D AU - Gokmen D AD - Department of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey. ISNI: 0000000109409118. GRID: grid.7256.6 FAU - Ozcan, A AU - Ozcan A AD - Ankara Research and Training Hospital, Ankara, Turkey. ISNI: 0000 0004 0642 6432. GRID: grid.413783.a FAU - Kaymak, C AU - Kaymak C AD - AnkaraNKARA Research and Training Hospital, Ankara, Turkey FAU - Artemenko, V A AU - Artemenko VA AD - MC Into-Sana, Odessa, Ukraine FAU - Budnyuk, A AU - Budnyuk A AD - MC Into-Sana, Odessa, Ukraine FAU - Pugh, R AU - Pugh R AD - Glan Clwyd Hospital, Rhyl, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 FAU - Bhandari, S AU - Bhandari S AD - Glan Clwyd Hospital, Rhyl, UK. ISNI: 0000 0000 9831 5916. GRID: grid.415564.7 FAU - Mauri, T AU - Mauri T AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Turrini, C AU - Turrini C AD - University of Ferrara, Sant’Anna Hospital, Ferrara, Italy FAU - Langer, T AU - Langer T AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Taccone, P AU - Taccone P AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Volta, C A AU - Volta CA AD - University of Ferrara, Sant’Anna Hospital, Ferrara, Italy FAU - Marenghi, C AU - Marenghi C AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Gattinoni, L AU - Gattinoni L AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Pesenti, A AU - Pesenti A AD - Fondazione IRCCS Ca’ Granda, Maggiore Policlinico Hospital, Milan, Italy FAU - Sweeney, L AU - Sweeney L AD - Aerogen, Galway, Ireland FAU - O’Sullivan, A AU - O’Sullivan A AD - Aerogen, Galway, Ireland FAU - Kelly, P AU - Kelly P AD - Aerogen, Galway, Ireland FAU - Mukeria, E AU - Mukeria E AD - Aerogen, Galway, Ireland FAU - MacLoughlin, R AU - MacLoughlin R AD - Aerogen, Galway, Ireland FAU - Pfeffer, M AU - Pfeffer M AD - Kaplan Medical Centre, Rehovot, Israel FAU - Thomas, J T AU - Thomas JT AD - West Virginia University, Morgantown, West Virginia USA. ISNI: 0000 0001 2156 6140. GRID: grid.268154.c FAU - Bregman, G B AU - Bregman GB AD - Kaplan Medical Centre, Rehovot, Israel FAU - Karp, G K AU - Karp GK AD - Kaplan Medical Centre, Rehovot, Israel FAU - Kishinevsky, E K AU - Kishinevsky EK AD - Kaplan Medical Centre, Rehovot, Israel FAU - Stavi, D S AU - Stavi DS AD - Kaplan Medical Centre, Rehovot, Israel FAU - Adi, N A AU - Adi NA AD - Kaplan Medical Centre, Rehovot, Israel FAU - Poropat, T AU - Poropat T AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Knafelj, R AU - Knafelj R AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Llopart, E AU - Llopart E AD - Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f FAU - Batlle, M AU - Batlle M AD - Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f FAU - De Haro, C AU - De Haro C AD - Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f FAU - Mesquida, J AU - Mesquida J AD - Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f FAU - Artigas, A AU - Artigas A AD - Corporació Sanitària i Universitària Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias, Sabadell, Barcelona, Spain. GRID: grid.7080.f FAU - Pavlovic, D AU - Pavlovic D AD - Dalhousie University, Halifax, Canada. ISNI: 0000 0004 1936 8200. GRID: grid.55602.34 FAU - Lewerentz, L AU - Lewerentz L AD - Ernst-Moritz-Arndt-Universität, Greifswald, Germany. GRID: grid.5603.0 FAU - Spassov, A AU - Spassov A AD - Ernst-Moritz-Arndt-Universität, Greifswald, Germany. GRID: grid.5603.0 FAU - Schneider, R AU - Schneider R AD - Ernst-Moritz-Arndt-Universität, Greifswald, Germany. GRID: grid.5603.0 FAU - De Smet, S AU - De Smet S AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - De Raedt, S AU - De Raedt S AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Derom, E AU - Derom E AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Depuydt, P AU - Depuydt P AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Oeyen, S AU - Oeyen S AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Benoit, D AU - Benoit D AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Decruyenaere, J AU - Decruyenaere J AD - Ghent University Hospital, Gent, Belgium. ISNI: 0000 0004 0626 3303. GRID: grid.410566.0 FAU - Gobatto, A AU - Gobatto A AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Besen, B AU - Besen B AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Tierno, P AU - Tierno P AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Melro, L AU - Melro L AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Mendes, P AU - Mendes P AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Cadamuro, F AU - Cadamuro F AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Park, M AU - Park M AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Malbouisson, L M AU - Malbouisson LM AD - Universidade de São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Civantos, B C AU - Civantos BC AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Lopez, J L AU - Lopez JL AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Robles, A AU - Robles A AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Figueira, J AU - Figueira J AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Yus, S AU - Yus S AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Garcia, A AU - Garcia A AD - Hospital La Paz, Madrid, Spain. ISNI: 0000 0000 8970 9163. GRID: grid.81821.32 FAU - Oglinda, A AU - Oglinda A AD - Institute of Mother and Child, Chisinau mun., Moldova FAU - Ciobanu, G AU - Ciobanu G AD - Institute of Emergency Medicine, Chisinau mun., Moldova FAU - Oglinda, C AU - Oglinda C AD - Institute of Mother and Child, Chisinau mun., Moldova FAU - Schirca, L AU - Schirca L AD - Institute of Mother and Child, Chisinau mun., Moldova FAU - Sertinean, T AU - Sertinean T AD - Institute of Mother and Child, Chisinau mun., Moldova FAU - Lupu, V AU - Lupu V AD - State University of Medicine and Pharmacy, Chisinau mun., Moldova FAU - Kelly, P AU - Kelly P AD - Aerogen, Galway, Ireland FAU - O’Sullivan, A AU - O’Sullivan A AD - Aerogen, Galway, Ireland FAU - Sweeney, L AU - Sweeney L AD - Aerogen, Galway, Ireland FAU - MacLoughlin, R AU - MacLoughlin R AD - Aerogen, Galway, Ireland FAU - O’Sullivan, A AU - O’Sullivan A AD - Aerogen, Galway, Ireland FAU - Kelly, P AU - Kelly P AD - Aerogen, Galway, Ireland FAU - Sweeney, L AU - Sweeney L AD - Aerogen, Galway, Ireland FAU - Mukeria, E AU - Mukeria E AD - Aerogen, Galway, Ireland FAU - Wolny, M AU - Wolny M AD - Aerogen, Galway, Ireland FAU - MacLoughlin, R AU - MacLoughlin R AD - Aerogen, Galway, Ireland FAU - Pagano, A AU - Pagano A AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Numis, F AU - Numis F AD - San Paolo Hospital, Naples, Italy FAU - Visone, G AU - Visone G AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Saldamarco, L AU - Saldamarco L AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Russo, T AU - Russo T AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Porta, G AU - Porta G AD - San Paolo Hospital, Naples, Italy FAU - Paladino, F AU - Paladino F AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Bell, C AU - Bell C AD - National University of Ireland, Galway, Galway City, Ireland. ISNI: 0000 0004 0488 0789. GRID: grid.6142.1 FAU - Liu, J AU - Liu J AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Debacker, J AU - Debacker J AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Lee, C AU - Lee C AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Tamberg, E AU - Tamberg E AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Campbell, V AU - Campbell V AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Mehta, S AU - Mehta S AD - Mount Sinai Hospital, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Silva-Pinto, A AU - Silva-Pinto A AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Sarmento, A AU - Sarmento A AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Santos, L AU - Santos L AD - Centro Hospitalar São João, Porto, Portugal. ISNI: 0000 0000 9375 4688. GRID: grid.414556.7 FAU - Kara, Ý AU - Kara Ý AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Yýldýrým, F AU - Yýldýrým F AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Zerman, A AU - Zerman A AD - Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey FAU - Güllü, Z AU - Güllü Z AD - Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey FAU - Boyacý, N AU - Boyacý N AD - Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey FAU - Basarýk Aydogan, B AU - Basarýk Aydogan B AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Gaygýsýz, Ü AU - Gaygýsýz Ü AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Gönderen, K AU - Gönderen K AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Arýk, G AU - Arýk G AD - Gazi University School of Medicine, Geriatrics Department, Ankara, Turkey FAU - Turkoglu, M AU - Turkoglu M AD - Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey FAU - Aydogdu, M AU - Aydogdu M AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Aygencel, G AU - Aygencel G AD - Gazi University School of Medicine, Internal Medicine Critical Care Department, Ankara, Turkey FAU - Ülger, Z AU - Ülger Z AD - Gazi University School of Medicine, Geriatrics Department, Ankara, Turkey FAU - Gursel, G AU - Gursel G AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Boyacý, N AU - Boyacý N AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Isýkdogan, Z AU - Isýkdogan Z AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Özdedeoglu, Ö AU - Özdedeoglu Ö AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Güllü, Z AU - Güllü Z AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Badoglu, M AU - Badoglu M AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Gaygýsýz, U AU - Gaygýsýz U AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Aydogdu, M AU - Aydogdu M AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Gursel, G AU - Gursel G AD - Gazi University School of Medicine Respiratory Medicine and Critical Care Department, Ankara, Turkey. ISNI: 0000 0001 2169 7132. GRID: grid.25769.3f FAU - Kongpolprom, N AU - Kongpolprom N AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Sittipunt, C AU - Sittipunt C AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Eden, A AU - Eden A AD - Carmel, Lady Davis Medical Center, Haifa, Israel. GRID: grid.471000.2 FAU - Kokhanovsky, Y AU - Kokhanovsky Y AD - Carmel, Lady Davis Medical Center, Haifa, Israel. GRID: grid.471000.2 FAU - Bursztein – De Myttenaere, S AU - Bursztein – De Myttenaere S AD - Carmel, Lady Davis Medical Center, Haifa, Israel. GRID: grid.471000.2 FAU - Pizov, R AU - Pizov R AD - Carmel, Lady Davis Medical Center, Haifa, Israel. GRID: grid.471000.2 FAU - Neilans, L AU - Neilans L AD - Duke University, Durham, USA. ISNI: 0000 0004 1936 7961. GRID: grid.26009.3d FAU - MacIntyre, N AU - MacIntyre N AD - Duke University, Durham, USA. ISNI: 0000 0004 1936 7961. GRID: grid.26009.3d FAU - Radosevich, M AU - Radosevich M AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Wanta, B AU - Wanta B AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Weber, V AU - Weber V AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Meyer, T AU - Meyer T AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Smischney, N AU - Smischney N AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Brown, D AU - Brown D AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Diedrich, D AU - Diedrich D AD - Mayo Clinic, Rochester, USA. ISNI: 0000 0004 0459 167X. GRID: grid.66875.3a FAU - Fuller, A AU - Fuller A AD - St Helens and Knoowsley, Prescot, UK FAU - McLindon, P AU - McLindon P AD - Royal Infirmary, Edinburgh, UK. ISNI: 0000 0001 0709 1919. GRID: grid.418716.d FAU - Sim, K AU - Sim K AD - St Helens and Knoowsley, Prescot, UK FAU - Shoaeir, M AU - Shoaeir M AD - Alexandria Universitry General Hospital, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Noeam, K AU - Noeam K AD - Alexandria Universitry General Hospital, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Mahrous, A AU - Mahrous A AD - Alexandria Universitry General Hospital, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Matsa, R AU - Matsa R AD - University Hospital North Middlands, Stoke On Trent, UK. ISNI: 0000 0004 0641 4263. GRID: grid.415598.4 FAU - Ali, A AU - Ali A AD - Alexandria Universitry General Hospital, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Dridi, C AU - Dridi C AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Koubaji, S AU - Koubaji S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Kamoun, S AU - Kamoun S AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Haddad, F AU - Haddad F AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Ben Souissi, A AU - Ben Souissi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Laribi, B AU - Laribi B AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Riahi, A AU - Riahi A AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Mebazaa, M S AU - Mebazaa MS AD - Mongi Slim University Hospital, La Marsa, Tunisia FAU - Pérez-Calatayud, A AU - Pérez-Calatayud A AD - Medica Sur, Mexico City, Mexico. GRID: grid.414741.3 FAU - Carrillo-Esper, R AU - Carrillo-Esper R AD - Medica Sur, Mexico City, Mexico. GRID: grid.414741.3 FAU - Zepeda-Mendoza, A AU - Zepeda-Mendoza A AD - Medica Sur, Mexico City, Mexico. GRID: grid.414741.3 FAU - Diaz-Carrillo, M AU - Diaz-Carrillo M AD - Medica Sur, Mexico City, Mexico. GRID: grid.414741.3 FAU - Arch-Tirado, E AU - Arch-Tirado E AD - Instituto Nacional de Rehabilitacion, Mexico City, Mexico. ISNI: 0000 0004 0633 2911. GRID: grid.419223.f FAU - Carbognin, S AU - Carbognin S AD - University of Padua, Padua, Italy. ISNI: 0000 0004 1757 3470. GRID: grid.5608.b FAU - Pelacani, L AU - Pelacani L AD - Sant Antony hospital, Padua, Italy FAU - Zannoni, F AU - Zannoni F AD - University of Padua, Padua, Italy. ISNI: 0000 0004 1757 3470. GRID: grid.5608.b FAU - Agnoli, A AU - Agnoli A AD - Sant Antony hospital, Padua, Italy FAU - Gagliardi, G AU - Gagliardi G AD - Sant Antony hospital, Padua, Italy FAU - Cho, R AU - Cho R AD - HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Adams, A AU - Adams A AD - HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Lunos, S AU - Lunos S AD - University of Minnesota, Minneapolis, USA. ISNI: 0000000419368657. GRID: grid.17635.36 FAU - Ambur, S AU - Ambur S AD - HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Shapiro, R AU - Shapiro R AD - HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Prekker, M AU - Prekker M AD - HCMC, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Thijssen, M AU - Thijssen M AD - Viecuri Medical Center, Venlo, Netherlands. ISNI: 0000 0004 0477 5022. GRID: grid.416856.8 FAU - Janssen, L AU - Janssen L AD - Viecuri Medical Center, Venlo, Netherlands. ISNI: 0000 0004 0477 5022. GRID: grid.416856.8 FAU - Foudraine, N AU - Foudraine N AD - Viecuri Medical Center, Venlo, Netherlands. ISNI: 0000 0004 0477 5022. GRID: grid.416856.8 FAU - Voscopoulos, C J AU - Voscopoulos CJ AD - University of Hawaii, John A. Burns School of Medicine, Honolulu, USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 FAU - Freeman, J AU - Freeman J AD - Respiratory Motion Inc., Waltham, USA FAU - Voscopoulos, C J AU - Voscopoulos CJ AD - University of Hawaii, John A. Burns School of Medicine, Honolulu, USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 FAU - Freeman, J AU - Freeman J AD - Respiratory Motion Inc., Waltham, USA FAU - George, E AU - George E AD - Massachusetts General Hospital, Boston, USA. ISNI: 0000 0004 0386 9924. GRID: grid.32224.35 FAU - Voscopoulos, C J AU - Voscopoulos CJ AD - University of Hawaii, John A. Burns School of Medicine, Honolulu, USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 FAU - Eversole, D AU - Eversole D AD - Respiratory Motion Inc., Waltham, USA FAU - Freeman, J AU - Freeman J AD - Respiratory Motion Inc., Waltham, USA FAU - George, E AU - George E AD - Massachusetts General Hospital, Boston, USA. ISNI: 0000 0004 0386 9924. GRID: grid.32224.35 FAU - Muttini, S AU - Muttini S AD - AO Desio e Vimercate, Vimercate, Italy FAU - Bigi, R AU - Bigi R AD - AO Desio e Vimercate, Vimercate, Italy FAU - Villani, G AU - Villani G AD - AO Crema, Crema, Italy FAU - Patroniti, N AU - Patroniti N AD - University of Milan-Bicocca, Monza, Italy. ISNI: 0000 0001 2174 1754. GRID: grid.7563.7 FAU - Williams, G AU - Williams G AD - UT Health Science Center at Houston, Houston, TX USA. ISNI: 0000 0000 9206 2401. GRID: grid.267308.8 FAU - Voscopoulos, C J AU - Voscopoulos CJ AD - University of Hawaii, John A. Burns School of Medicine, Honolulu, HI USA. ISNI: 0000 0001 2188 0957. GRID: grid.410445.0 FAU - Freeman, J AU - Freeman J AD - Respiratory Motion Inc., Waltham, MA USA FAU - George, E AU - George E AD - Massachusetts General Hospital, Boston, MA USA. ISNI: 0000 0004 0386 9924. GRID: grid.32224.35 FAU - Waldmann, A AU - Waldmann A AD - Swisstom AG, Landquart, Switzerland FAU - Böhm, S AU - Böhm S AD - Swisstom AG, Landquart, Switzerland FAU - Windisch, W AU - Windisch W AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten / Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Strassmann, S AU - Strassmann S AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten / Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Karagiannidis, C AU - Karagiannidis C AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten / Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Waldmann, A AU - Waldmann A AD - Swisstom AG, Landquart, Switzerland FAU - Böhm, S AU - Böhm S AD - Swisstom AG, Landquart, Switzerland FAU - Windisch, W AU - Windisch W AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten/ Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Strassmann, S AU - Strassmann S AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten/ Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Karagiannidis, C AU - Karagiannidis C AD - Kliniken der Stadt Köln, Pneumology and Critical Care Medicine, Witten/ Herdecke University, Ostmerheimer Str. 200, 51109 Cologne, Germany. ISNI: 0000 0000 9024 6397. GRID: grid.412581.b FAU - Karagiannidis, C K AU - Karagiannidis CK AD - ARDS and ECMO Center Köln-Merheim, Cologne, Germany FAU - Waldmann, A W AU - Waldmann AW AD - Swisstom, Chur, Switzerland FAU - Böhm, S B AU - Böhm SB AD - Swisstom, Chur, Switzerland FAU - Strassmann, S AU - Strassmann S AD - ARDS and ECMO Center Köln-Merheim, Cologne, Germany FAU - Windisch, W W AU - Windisch WW AD - ARDS and ECMO Center Köln-Merheim, Cologne, Germany FAU - Persson, P AU - Persson P AD - Sahlgrenska Univ Hospital, Göteborg, Sweden. ISNI: 000000009445082X. GRID: grid.1649.a FAU - Lundin, S AU - Lundin S AD - Sahlgrenska Univ Hospital, Göteborg, Sweden. ISNI: 000000009445082X. GRID: grid.1649.a FAU - Stenqvist, O AU - Stenqvist O AD - Sahlgrenska Univ Hospital, Göteborg, Sweden. ISNI: 000000009445082X. GRID: grid.1649.a FAU - Porta, G AU - Porta G AD - Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 FAU - Numis, F AU - Numis F AD - San Paolo Hospital, Naples, Italy FAU - Serra, C S AU - Serra CS AD - University of Sassari, Sassari, Italy. ISNI: 0000 0001 2097 9138. GRID: grid.11450.31 FAU - Pagano, A P AU - Pagano AP AD - Cardarelli Hospital, Naples, Italy. GRID: grid.413172.2 FAU - Masarone, M M AU - Masarone MM AD - University of Saerno, Salerno, Italy FAU - Rinaldi, L R AU - Rinaldi LR AD - Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 FAU - Amelia, A A AU - Amelia AA AD - Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 FAU - Fascione, M F AU - Fascione MF AD - Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 FAU - Adinolfi, L A AU - Adinolfi LA AD - Second University of Naples, Naples, Italy. ISNI: 0000 0001 2200 8888. GRID: grid.9841.4 FAU - Ruggiero, E R AU - Ruggiero ER AD - San Paolo Hospital, Naples, Italy FAU - Asota, F AU - Asota F AD - East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK FAU - O’Rourke, K AU - O’Rourke K AD - East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK FAU - Ranjan, S AU - Ranjan S AD - East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK FAU - Morgan, P AU - Morgan P AD - East Surrey Hospital, Surrey and Sussex NHS Trust, Surrey, UK FAU - DeBacker, J W AU - DeBacker JW AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Tamberg, E AU - Tamberg E AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - O’Neill, L AU - O’Neill L AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Munshi, L AU - Munshi L AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Burry, L AU - Burry L AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Fan, E AU - Fan E AD - University Health Network-Toronto General Hospital and Univeristy of Toronto, Toronto, Canada. ISNI: 0000 0001 0661 1177. GRID: grid.417184.f FAU - Mehta, S AU - Mehta S AD - Mount Sinai Hospital and University of Toronto, Toronto, Canada. ISNI: 0000 0004 0473 9881. GRID: grid.416166.2 FAU - Poo, S AU - Poo S AD - University of Cambridge, Cambridge, UK. ISNI: 0000000121885934. GRID: grid.5335.0 FAU - Mahendran, K AU - Mahendran K AD - Papworth Hospital, Cambridge, UK. ISNI: 0000 0004 0399 2308. GRID: grid.417155.3 FAU - Fowles, J AU - Fowles J AD - Papworth Hospital, Cambridge, UK. ISNI: 0000 0004 0399 2308. GRID: grid.417155.3 FAU - Gerrard, C AU - Gerrard C AD - Papworth Hospital, Cambridge, UK. ISNI: 0000 0004 0399 2308. GRID: grid.417155.3 FAU - Vuylsteke, A AU - Vuylsteke A AD - Papworth Hospital, Cambridge, UK. ISNI: 0000 0004 0399 2308. GRID: grid.417155.3 FAU - Loveridge, R AU - Loveridge R AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Chaddock, C AU - Chaddock C AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Patel, S AU - Patel S AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Kakar, V AU - Kakar V AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Willars, C AU - Willars C AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Hurst, T AU - Hurst T AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Park, C AU - Park C AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Best, T AU - Best T AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Vercueil, A AU - Vercueil A AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Auzinger, G AU - Auzinger G AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Borgman, A AU - Borgman A AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Proudfoot, A G AU - Proudfoot AG AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Grins, E AU - Grins E AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Emiley, K E AU - Emiley KE AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Schuitema, J AU - Schuitema J AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Fitch, S J AU - Fitch SJ AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Marco, G AU - Marco G AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Sturgill, J AU - Sturgill J AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Dickinson, M G AU - Dickinson MG AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Strueber, M AU - Strueber M AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Khaghani, A AU - Khaghani A AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Wilton, P AU - Wilton P AD - Meijer Heart & Vascular Institute, Grand Rapids, USA FAU - Jovinge, S M AU - Jovinge SM FAU - Sampson, C AU - Sampson C AD - Glenfield Hospital, UHL, Leicester, UK. ISNI: 0000 0004 0648 9396. GRID: grid.416025.4 FAU - Harris-Fox, S AU - Harris-Fox S AD - Glenfield Hospital, UHL, Leicester, UK. ISNI: 0000 0004 0648 9396. GRID: grid.416025.4 FAU - Cove, M E AU - Cove ME AD - National University Hospital, Singapore, Singapore. ISNI: 0000 0004 0621 9599. GRID: grid.412106.0 FAU - Vu, L H AU - Vu LH AD - National University Singapore, Singapore, Singapore. ISNI: 0000 0001 2180 6431. GRID: grid.4280.e FAU - Sen, A AU - Sen A AD - Mayo Clinic, Phoenix, AZ USA. ISNI: 0000 0000 8875 6339. GRID: grid.417468.8 FAU - Federspiel, W J AU - Federspiel WJ AD - University of Pittsburgh, Pittsburgh, PA USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d FAU - Kellum, J A AU - Kellum JA AD - University of Pittsburgh, Pittsburgh, PA USA. ISNI: 0000 0004 1936 9000. GRID: grid.21925.3d FAU - Mazo Torre, C AU - Mazo Torre C AD - Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f FAU - Riera, J AU - Riera J AD - Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f FAU - Ramirez, S AU - Ramirez S AD - Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f FAU - Borgatta, B AU - Borgatta B AD - Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f FAU - Lagunes, L AU - Lagunes L AD - Vall D’Hebron University Hospital, Barcelona, Spain. ISNI: 0000 0001 0675 8654. GRID: grid.411083.f FAU - Rello, J AU - Rello J AD - Universitat Autonoma de Barcelona, Barcelona, Spain. GRID: grid.7080.f FAU - Kuzovlev, A K AU - Kuzovlev AK AD - V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia FAU - Moroz, V AU - Moroz V AD - V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia FAU - Goloubev, A AU - Goloubev A AD - V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia FAU - Polovnikov, S AU - Polovnikov S AD - NN Burdenko Main Military Hospital, Moscow, Russia FAU - Nenchuk, S AU - Nenchuk S AD - NN Burdenko Main Military Hospital, Moscow, Russia FAU - Karavana, V AU - Karavana V AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Glynos, C AU - Glynos C AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Asimakos, A AU - Asimakos A AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Pappas, K AU - Pappas K AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Vrettou, C AU - Vrettou C AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Magkou, M AU - Magkou M AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Ischaki, E AU - Ischaki E AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Stathopoulos, G AU - Stathopoulos G AD - University of Patras, Rio, Achaia Greece. ISNI: 0000 0004 0576 5395. GRID: grid.11047.33 FAU - Zakynthinos, S AU - Zakynthinos S AD - George P. Livanos and Marianthi Simou Laboratories, Athens, Greece FAU - Spadaro, S AU - Spadaro S AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Kozhevnikova, I AU - Kozhevnikova I AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Dalla Corte, F AU - Dalla Corte F AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Grasso, S AU - Grasso S AD - University of Bari, Bari, Italy. ISNI: 0000 0001 0120 3326. GRID: grid.7644.1 FAU - Casolari, P AU - Casolari P AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Caramori, G AU - Caramori G AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Volta, C AU - Volta C AD - University of Ferrara, Ferrara, Italy. ISNI: 0000 0004 1757 2064. GRID: grid.8484.0 FAU - Andrianjafiarinoa, T AU - Andrianjafiarinoa T AD - CHU HJRA, Antananarivo, Madagascar FAU - Randriamandrato, T AU - Randriamandrato T AD - CHU HJRA, Antananarivo, Madagascar FAU - Rajaonera, T AU - Rajaonera T AD - CHU HJRA, Antananarivo, Madagascar FAU - El-Dash, S AU - El-Dash S AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Costa, E L V AU - Costa ELV AD - Cardio-Pulmonary Department, Pulmonary Division, Heart Institute (Incor), University of São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Tucci, M R AU - Tucci MR AD - Cardio-Pulmonary Department, Pulmonary Division, Heart Institute (Incor), University of São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Leleu, F AU - Leleu F AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Kontar, L AU - Kontar L AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - De Cagny, B AU - De Cagny B AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Brazier, F AU - Brazier F AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Titeca, D AU - Titeca D AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Bacari-Risal, G AU - Bacari-Risal G AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Maizel, J AU - Maizel J AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Amato, M AU - Amato M AD - Cardio-Pulmonary Department, Pulmonary Division, Heart Institute (Incor), University of São Paulo, São Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Slama, M AU - Slama M AD - Réanimation médicale, Centre Hospitalier Universitaire, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Mercado, P AU - Mercado P AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Maizel, J AU - Maizel J AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Kontar, L AU - Kontar L AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Titeca, D AU - Titeca D AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Brazier, F AU - Brazier F AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Riviere, A AU - Riviere A AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Joris, M AU - Joris M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Soupison, T AU - Soupison T AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - De Cagny, B AU - De Cagny B AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - El Dash, S AU - El Dash S AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Slama, M AU - Slama M AD - CHU Amiens, Amiens, France. ISNI: 0000 0004 0593 702X. GRID: grid.134996.0 FAU - Remmington AU - Remmington AD - Royal Brompton Hospital, London, UK. GRID: grid.439338.6 FAU - Fischer, A AU - Fischer A AD - Royal Brompton Hospital, London, UK. GRID: grid.439338.6 FAU - Squire, S AU - Squire S AD - Royal Brompton Hospital, London, UK. GRID: grid.439338.6 FAU - Boichat, M AU - Boichat M AD - Royal Brompton Hospital, London, UK. GRID: grid.439338.6 FAU - Honzawa, H AU - Honzawa H AD - Musashino Red Cross Hospital, Tokyo, Japan. ISNI: 0000 0000 9887 307X. GRID: grid.416332.1 FAU - Yasuda, H AU - Yasuda H AD - Musashino Red Cross Hospital, Tokyo, Japan. ISNI: 0000 0000 9887 307X. GRID: grid.416332.1 FAU - Adati, T AU - Adati T AD - Musashino Red Cross Hospital, Tokyo, Japan. ISNI: 0000 0000 9887 307X. GRID: grid.416332.1 FAU - Suzaki, S AU - Suzaki S AD - Musashino Red Cross Hospital, Tokyo, Japan. ISNI: 0000 0000 9887 307X. GRID: grid.416332.1 FAU - Horibe, M AU - Horibe M AD - JSEPTIC Clinical Trial Group, Tokyo, Japan FAU - Sasaki, M AU - Sasaki M AD - JSEPTIC Clinical Trial Group, Tokyo, Japan FAU - Sanui, M AU - Sanui M AD - JSEPTIC Clinical Trial Group, Tokyo, Japan FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Daniel, J AU - Daniel J AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Miranda, H AU - Miranda H AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, A AU - Marinho A FAU - Milinis, K AU - Milinis K AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - Cooper, M AU - Cooper M AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Williams, G R AU - Williams GR AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - McCarron, E AU - McCarron E AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Simants, S AU - Simants S AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Patanwala, I AU - Patanwala I AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Welters, I AU - Welters I AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - Su, Y AU - Su Y AD - Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan FAU - Fernández Villanueva, J AU - Fernández Villanueva J AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Fernández Garda, R AU - Fernández Garda R AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - López Lago, A AU - López Lago A AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Rodríguez Ruíz, E AU - Rodríguez Ruíz E AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Hernández Vaquero, R AU - Hernández Vaquero R AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Tomé Martínez de Rituerto, S AU - Tomé Martínez de Rituerto S AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Varo Pérez, E AU - Varo Pérez E AD - Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain. ISNI: 0000 0000 8816 6945. GRID: grid.411048.8 FAU - Lefel, N AU - Lefel N AD - MUMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Schaap, F AU - Schaap F AD - MUMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Bergmans, D AU - Bergmans D AD - MUMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Olde Damink, S AU - Olde Damink S AD - MUMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Van de Poll, M AU - Van de Poll M AD - MUMC, Maastricht, Netherlands. GRID: grid.412966.e FAU - Tizard, K AU - Tizard K AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Lister, C AU - Lister C AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Poole, L AU - Poole L AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Ringaitiene, D AU - Ringaitiene D AD - Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. ISNI: 0000 0004 0567 3159. GRID: grid.426597.b FAU - Gineityte, D AU - Gineityte D AD - Vilnius University, Faculty of Medicine, Vilnius, Lithuania FAU - Vicka, V AU - Vicka V AD - Vilnius University, Faculty of Medicine, Vilnius, Lithuania FAU - Norkiene, I AU - Norkiene I AD - Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. ISNI: 0000 0004 0567 3159. GRID: grid.426597.b FAU - Sipylaite, J AU - Sipylaite J AD - Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania. ISNI: 0000 0004 0567 3159. GRID: grid.426597.b FAU - O’Loughlin, A AU - O’Loughlin A AD - Mercy University Hospital, Cork, Ireland. ISNI: 0000 0004 0575 9497. GRID: grid.411785.e FAU - Maraj, V AU - Maraj V AD - Mercy University Hospital, Cork, Ireland. ISNI: 0000 0004 0575 9497. GRID: grid.411785.e FAU - Dowling, J AU - Dowling J AD - Mercy University Hospital, Cork, Ireland. ISNI: 0000 0004 0575 9497. GRID: grid.411785.e FAU - Velasco, M B AU - Velasco MB AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Dalcomune, D M AU - Dalcomune DM AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Dias, E B AU - Dias EB AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Fernandes, S L AU - Fernandes SL AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Oshima, T AU - Oshima T AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Graf, S AU - Graf S AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Heidegger, C AU - Heidegger C AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Genton, L AU - Genton L AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Karsegard, V AU - Karsegard V AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Dupertuis, Y AU - Dupertuis Y AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Pichard, C AU - Pichard C AD - Geneva Universtiy Hospital, Geneva, Switzerland. ISNI: 0000 0001 0721 9812. GRID: grid.150338.c FAU - Friedli, N AU - Friedli N AD - Medical University Department, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Stanga, Z AU - Stanga Z AD - Department of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Bern, Bern, Switzerland. ISNI: 0000 0004 0479 0855. GRID: grid.411656.1 FAU - Mueller, B AU - Mueller B AD - Medical University Department, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schuetz, P AU - Schuetz P AD - Medical University Department, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Vandersteen, L AU - Vandersteen L AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Stessel, B AU - Stessel B AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Evers, S AU - Evers S AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Van Assche, A AU - Van Assche A AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Jamaer, L AU - Jamaer L AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Dubois, J AU - Dubois J AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Castro, H AU - Castro H AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Moura, J AU - Moura J AD - Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal FAU - Valente, J AU - Valente J AD - Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal FAU - Martins, P AU - Martins P AD - Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Casteloes, P AU - Casteloes P AD - Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal. ISNI: 0000 0000 8902 4519. GRID: grid.418336.b FAU - Magalhaes, C AU - Magalhaes C AD - Centro Hospitalar do Algarve, Faro, Portugal FAU - Cabral, S AU - Cabral S AD - Instituto Portugues de Oncologia do Porto, Porto, Portugal. GRID: grid.435544.7 FAU - Santos, M AU - Santos M AD - Faculdade de Ciencias da Nutricao e Alimentacao da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Oliveira, B AU - Oliveira B AD - Faculdade de Ciencias da Nutricao e Alimentacao da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Salgueiro, A AU - Salgueiro A AD - Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Santos, M AU - Santos M AD - Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Lafuente, E AU - Lafuente E AD - Centro Hospitalar Tamega e Sousa, Penafiel, Portugal. GRID: grid.466592.a FAU - Castro, H AU - Castro H AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Cabral, S AU - Cabral S AD - Instituto Português de Oncologia do Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Moura, J AU - Moura J AD - Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal FAU - Martins, P AU - Martins P AD - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Oliveira, B AU - Oliveira B AD - Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Salgueiro, A AU - Salgueiro A AD - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Duarte, S AU - Duarte S AD - Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal FAU - Castro, S AU - Castro S AD - Centro Hospitalar do Algarve, Faro, Portugal FAU - Melo, M AU - Melo M AD - Centro Hospitalar do Baixo Vouga, Aveiro, Portugal FAU - Casteloes, P AU - Casteloes P AD - Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal. ISNI: 0000 0000 8902 4519. GRID: grid.418336.b FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Gray, S AU - Gray S AD - Nottingham University Hospital NHS Trust, Nottingham, UK. ISNI: 0000 0001 0440 1889. GRID: grid.240404.6 FAU - Maipang, K AU - Maipang K AD - Prince of Songkla University, Songkla, Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Bhurayanontachai, R AU - Bhurayanontachai R AD - Prince of Songkla University, Songkla, Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Grädel, L G AU - Grädel LG AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schütz, P AU - Schütz P AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Langlois, P AU - Langlois P AD - Université de Sherbrooke, Sherbrooke, Canada. ISNI: 0000 0000 9064 6198. GRID: grid.86715.3d FAU - Manzanares, W AU - Manzanares W AD - University Hospital, Montevideo, Uruguay FAU - Tincu, R AU - Tincu R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Cobilinschi, C AU - Cobilinschi C AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Tomescu, D AU - Tomescu D AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Ghiorghiu, Z AU - Ghiorghiu Z AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Macovei, R AU - Macovei R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Manzanares, W AU - Manzanares W AD - University Hospital, Montevideo, Uruguay FAU - Langlois, P AU - Langlois P AD - Université de Sherbrooke, Sherbrooke, Canada. ISNI: 0000 0000 9064 6198. GRID: grid.86715.3d FAU - Lemieux, M AU - Lemieux M AD - Queen’s University, Kingston, Canada. ISNI: 0000 0004 1936 8331. GRID: grid.410356.5 FAU - Elke, G AU - Elke G AD - University Medical Center Schleswig-Holstein, Kiel, Germany. ISNI: 0000 0004 0646 2097. GRID: grid.412468.d FAU - Bloos, F AU - Bloos F AD - University of Jena, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Reinhart, K AU - Reinhart K AD - University of Jena, Jena, Germany. ISNI: 0000 0001 1939 2794. GRID: grid.9613.d FAU - Heyland, D AU - Heyland D AD - Queen’s University, Kingston, Canada. ISNI: 0000 0004 1936 8331. GRID: grid.410356.5 FAU - Langlois, P AU - Langlois P AD - Université de Sherbrooke, Sherbrooke, Canada. ISNI: 0000 0000 9064 6198. GRID: grid.86715.3d FAU - Lemieux, M AU - Lemieux M AD - Queen’s University, Kingston, Canada. ISNI: 0000 0004 1936 8331. GRID: grid.410356.5 FAU - Aramendi, I AU - Aramendi I AD - University Hospital, Montevideo, Uruguay FAU - Heyland, D AU - Heyland D AD - Queen’s University, Kingston, Canada. ISNI: 0000 0004 1936 8331. GRID: grid.410356.5 FAU - Manzanares, W AU - Manzanares W AD - University Hospital, Montevideo, Uruguay FAU - Su, Y AU - Su Y AD - Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi County, Taiwan FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Babo, N AU - Babo N AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Hoshino, M AU - Hoshino M AD - Aida Hospital, Fukushima, Japan FAU - Haraguchi, Y AU - Haraguchi Y AD - Keiyo Hospital, Tokyo, Japan FAU - Kajiwara, S AU - Kajiwara S AD - Aida Hospital, Fukushima, Japan FAU - Mitsuhashi, T AU - Mitsuhashi T AD - Shisei Hospital, Saitama, Japan FAU - Tsubata, T AU - Tsubata T AD - Keiyo Hospital, Tokyo, Japan FAU - Aida, M AU - Aida M AD - Aida Hospital, Fukushima, Japan FAU - Rattanapraphat, T AU - Rattanapraphat T AD - Prince of Songkla University, Hat Yai City, Songkhla Province Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Bhurayanontachai, R AU - Bhurayanontachai R AD - Prince of Songkla University, Hat Yai City, Songkhla Province Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Kongkamol, C AU - Kongkamol C AD - Prince of Songkla University, Hat Yai City, Songkhla Province Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Khwannimit, B AU - Khwannimit B AD - Prince of Songkla University, Hat Yai City, Songkhla Province Thailand. ISNI: 0000 0004 0470 1162. GRID: grid.7130.5 FAU - Marinho, R AU - Marinho R AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Santos, M AU - Santos M AD - Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Castro, H AU - Castro H AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Lafuente, E AU - Lafuente E AD - Centro Hospitalar Tamega e Sousa, Penafiel, Portugal. GRID: grid.466592.a FAU - Salgueiro, A AU - Salgueiro A AD - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Cabral, S AU - Cabral S AD - Instituto Português de Oncologia do Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Martins, P AU - Martins P AD - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Moura, J AU - Moura J AD - Unidade Local de Saude do Alto Minho, Viana do Castelo, Portugal FAU - Oliveira, B AU - Oliveira B AD - Faculdade de Ciencias da Nutrição e Alimentação da Universidade do Porto, Porto, Portugal. ISNI: 0000 0001 1503 7226. GRID: grid.5808.5 FAU - Melo, M AU - Melo M AD - Centro Hospitalar Baixo Vouga, Aveiro, Portugal FAU - Xavier, B AU - Xavier B AD - Centro Hospitalar Baixo Vouga, Aveiro, Portugal FAU - Valente, J AU - Valente J AD - Unidade de Saude Local de Castelo Branco, Castelo Branco, Portugal FAU - Magalhaes, C AU - Magalhaes C AD - Centro Hospitalar do Algarve, Faro, Portugal FAU - Casteloes, P AU - Casteloes P AD - Centro Hospitalar de Vila Nova de Gaia, Vila Nova de Gaia, Portugal. ISNI: 0000 0000 8902 4519. GRID: grid.418336.b FAU - Marinho, A AU - Marinho A AD - Centro Hospitalar do Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Moisidou, D AU - Moisidou D AD - Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Ampatzidou, F AU - Ampatzidou F AD - Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Koutsogiannidis, C AU - Koutsogiannidis C AD - Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Moschopoulou, M AU - Moschopoulou M AD - Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Drossos, G AU - Drossos G AD - Department of Cardiothoracic Surgery, George Papanikolaou General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0576 574X. GRID: grid.415248.e FAU - Taskin, G AU - Taskin G AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Çakir, M AU - Çakir M AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Güler, AK AU - Güler AK AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Taskin, A AU - Taskin A AD - Ankara Mevki Military Hospital, Ankara, Turkey. GRID: grid.461837.f FAU - Öcal, N AU - Öcal N AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Özer, S AU - Özer S AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Yamanel, L AU - Yamanel L AD - Gülhane Military Medical Academy, Ankara, Turkey. ISNI: 0000 0001 0720 6034. GRID: grid.413460.4 FAU - Wong, J M AU - Wong JM AD - St Bartholomew’s Hospital, London, UK. ISNI: 0000 0000 9244 0345. GRID: grid.416353.6 FAU - Fitton, C AU - Fitton C AD - St Bartholomew’s Hospital, London, UK. ISNI: 0000 0000 9244 0345. GRID: grid.416353.6 FAU - Anwar, S AU - Anwar S AD - St Bartholomew’s Hospital, London, UK. ISNI: 0000 0000 9244 0345. GRID: grid.416353.6 FAU - Stacey, S AU - Stacey S AD - St Bartholomew’s Hospital, London, UK. ISNI: 0000 0000 9244 0345. GRID: grid.416353.6 FAU - Aggou, M AU - Aggou M AD - Aristotle Medical School, Thessaloniki, Greece FAU - Fyntanidou, B AU - Fyntanidou B AD - Aristotle Medical School, Thessaloniki, Greece FAU - Patsatzakis, S AU - Patsatzakis S AD - Aristotle Medical School, Thessaloniki, Greece FAU - Oloktsidou, E AU - Oloktsidou E AD - Aristotle Medical School, Thessaloniki, Greece FAU - Lolakos, K AU - Lolakos K AD - Aristotle Medical School, Thessaloniki, Greece FAU - Papapostolou, E AU - Papapostolou E AD - Aristotle Medical School, Thessaloniki, Greece FAU - Grosomanidis, V AU - Grosomanidis V AD - Aristotle Medical School, Thessaloniki, Greece FAU - Suda, S AU - Suda S AD - Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ikeda, T AU - Ikeda T AD - Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ono, S AU - Ono S AD - Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Ueno, T AU - Ueno T AD - Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Izutani, Y AU - Izutani Y AD - Tokyo Medical University Hachiosi Medical Center, Tokyo, Japan. ISNI: 0000 0001 0663 3325. GRID: grid.410793.8 FAU - Gaudry, S AU - Gaudry S AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Desailly, V AU - Desailly V AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Pasquier, P AU - Pasquier P AD - Laboratoire ILUMENS, Paris, France FAU - Brun, PB AU - Brun PB AD - Institut de Hauts de Seine, Nanterre, France FAU - Tesnieres, AT AU - Tesnieres AT AD - Laboratoire ILUMENS, Paris, France FAU - Ricard, JD AU - Ricard JD AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Dreyfuss, D AU - Dreyfuss D AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Mignon, A AU - Mignon A AD - Laboratoire ILUMENS, Paris, France FAU - White, J C AU - White JC AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Molokhia, A AU - Molokhia A AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Dean, A AU - Dean A AD - Queen Elizabeth Hospital, London, UK. GRID: grid.439484.6 FAU - Stilwell, A AU - Stilwell A AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Friedlaender, G AU - Friedlaender G AD - Minet Green Health Practice, London, UK FAU - Peters, M AU - Peters M AD - Department of Public Health, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b FAU - Stipulante, S AU - Stipulante S AD - Department of Public Health, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b FAU - Delfosse, A AU - Delfosse A AD - Department of Emergency Medicine, University Hospital of Liège, Liège, Belgium. ISNI: 0000 0000 8607 6858. GRID: grid.411374.4 FAU - Donneau, AF AU - Donneau AF AD - Department of Medical Biostatistics, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b FAU - Ghuysen, A AU - Ghuysen A AD - Department of Public Health, University of Liège, Liège, Belgium. ISNI: 0000 0001 0805 7253. GRID: grid.4861.b FAU - Feldmann, C AU - Feldmann C AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Freitag, D AU - Freitag D AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Dersch, W AU - Dersch W AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Irqsusi, M AU - Irqsusi M AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Eschbach, D AU - Eschbach D AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Steinfeldt, T AU - Steinfeldt T AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Wulf, H AU - Wulf H AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Wiesmann, T AU - Wiesmann T AD - University Hospital, Philipps University Marburg, Marburg, Germany. ISNI: 0000 0004 1936 9756. GRID: grid.10253.35 FAU - Kongpolprom, N AU - Kongpolprom N AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Cholkraisuwat, J AU - Cholkraisuwat J AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Beitland, S AU - Beitland S AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Nakstad, E AU - Nakstad E AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Stær-Jensen, H AU - Stær-Jensen H AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Drægni, T AU - Drægni T AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Andersen, G AU - Andersen G AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Jacobsen, D AU - Jacobsen D AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Brunborg, C AU - Brunborg C AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Waldum-Grevbo, B AU - Waldum-Grevbo B AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Sunde, K AU - Sunde K AD - Oslo University Hospital, Oslo, Norway. ISNI: 0000 0004 0389 8485. GRID: grid.55325.34 FAU - Hoyland, K AU - Hoyland K AD - William Harvey Hospital, Ashford, UK. ISNI: 0000 0004 0398 7998. GRID: grid.417122.3 FAU - Pandit, D AU - Pandit D AD - William Harvey Hospital, Ashford, UK. ISNI: 0000 0004 0398 7998. GRID: grid.417122.3 FAU - Hayakawa, K AU - Hayakawa K AD - Kansai Medical University Takii Hospital, Moriguchi, Japan. GRID: grid.410783.9 FAU - Oloktsidou, E AU - Oloktsidou E AD - Aristotle Medical School, Thessaloniki, Greece FAU - Kotzampassi, K AU - Kotzampassi K AD - Aristotle Medical School, Thessaloniki, Greece FAU - Fyntanidou, B AU - Fyntanidou B AD - Aristotle Medical School, Thessaloniki, Greece FAU - Patsatzakis, S AU - Patsatzakis S AD - Aristotle Medical School, Thessaloniki, Greece FAU - Loukipoudi, L AU - Loukipoudi L AD - Aristotle Medical School, Thessaloniki, Greece FAU - Doumaki, E AU - Doumaki E AD - Aristotle Medical School, Thessaloniki, Greece FAU - Grosomanidis, V AU - Grosomanidis V AD - Aristotle Medical School, Thessaloniki, Greece FAU - Yasuda, H AU - Yasuda H AD - Japanese Red Cross Musashino Hospital, Tokyo, Japan. ISNI: 0000 0004 1762 2623. GRID: grid.410775.0 FAU - Admiraal, M M AU - Admiraal MM AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Assen, M AU - Van Assen M AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Putten, M J AU - Van Putten MJ AD - Medisch Spectrum Twente, Enschede, Netherlands. ISNI: 0000 0004 0399 8347. GRID: grid.415214.7 FAU - Tjepkema-Cloostermans, M AU - Tjepkema-Cloostermans M AD - Medisch Spectrum Twente, Enschede, Netherlands. ISNI: 0000 0004 0399 8347. GRID: grid.415214.7 FAU - Van Rootselaar, A F AU - Van Rootselaar AF AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Horn, J AU - Horn J AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Ragusa, F AU - Ragusa F AD - University Modena, Modena, Italy. ISNI: 0000000121697570. GRID: grid.7548.e FAU - Marudi, A AU - Marudi A AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Baroni, S AU - Baroni S AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Gaspari, A AU - Gaspari A AD - University Modena, Modena, Italy. ISNI: 0000000121697570. GRID: grid.7548.e FAU - Bertellini, E AU - Bertellini E AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Taha, A AU - Taha A AD - Faculty of Medicine Alexandria University, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Abdullah, T AU - Abdullah T AD - Faculty of Medicine Alexandria University, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Abdel Monem, S AU - Abdel Monem S AD - Faculty of Medicine Alexandria University, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Alcorn, S AU - Alcorn S AD - Victoria Hospital, Kirkcaldy, UK. ISNI: 0000 0004 0624 9667. GRID: grid.416854.a FAU - McNeill, S AU - McNeill S AD - Victoria Hospital, Kirkcaldy, UK. ISNI: 0000 0004 0624 9667. GRID: grid.416854.a FAU - Russell, S AU - Russell S AD - Victoria Hospital, Kirkcaldy, UK. ISNI: 0000 0004 0624 9667. GRID: grid.416854.a FAU - Eertmans, W AU - Eertmans W AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - Genbrugge, C AU - Genbrugge C AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - Meex, I AU - Meex I AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - Dens, J AU - Dens J AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - Jans, F AU - Jans F AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - De Deyne, C AU - De Deyne C AD - Ziekenhuis Oost-Limburg, Genk, Belgium. ISNI: 0000 0004 0612 7379. GRID: grid.470040.7 FAU - Cholkraisuwat, J AU - Cholkraisuwat J AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Kongpolprom, N AU - Kongpolprom N AD - Chulalongkorn University, Bangkok, Thailand. ISNI: 0000 0001 0244 7875. GRID: grid.7922.e FAU - Avard, B AU - Avard B AD - The Canberra Hospital, Hughes, ACT Australia. ISNI: 0000 0000 9984 5644. GRID: grid.413314.0 FAU - Burns, R AU - Burns R AD - ANU Medical School, Canberra, Australia. ISNI: 0000 0001 2180 7477. GRID: grid.1001.0 FAU - Patarchi, A AU - Patarchi A AD - “Spirito Santo” Hospital, Pescara, Italy. GRID: grid.416240.5 FAU - Spina, T AU - Spina T AD - “Spirito Santo” Hospital, Pescara, Italy. GRID: grid.416240.5 FAU - Tanaka, H AU - Tanaka H AD - St Lukes International Hospital, Akashi-Chou Chuo-Ku, Japan. GRID: grid.430395.8 FAU - Otani, N AU - Otani N AD - St Lukes International Hospital, Akashi-Chou Chuo-Ku, Japan. GRID: grid.430395.8 FAU - Ode, S AU - Ode S AD - St Lukes International Hospital, Akashi-Chou Chuo-Ku, Japan. GRID: grid.430395.8 FAU - Ishimatsu, S AU - Ishimatsu S AD - St Lukes International Hospital, Akashi-Chou Chuo-Ku, Japan. GRID: grid.430395.8 FAU - Cho, J AU - Cho J AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Moon, J B AU - Moon JB AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Park, C W AU - Park CW AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Ohk, T G AU - Ohk TG AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Shin, M C AU - Shin MC AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Won, M H AU - Won MH AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Dakova, S AU - Dakova S AD - Military Medical Academy, Sofia, Bulgaria. ISNI: 0000 0004 0621 0228. GRID: grid.413126.3 FAU - Ramsheva, Z AU - Ramsheva Z AD - Military Medical Academy, Sofia, Bulgaria. ISNI: 0000 0004 0621 0228. GRID: grid.413126.3 FAU - Ramshev, K AU - Ramshev K AD - Military Medical Academy, Sofia, Bulgaria. ISNI: 0000 0004 0621 0228. GRID: grid.413126.3 FAU - Cho, J AU - Cho J AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Moon, J B AU - Moon JB AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Park, C W AU - Park CW AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Ohk, T G AU - Ohk TG AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Shin, M C AU - Shin MC AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Cho, J AU - Cho J AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Moon, J B AU - Moon JB AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Park, C W AU - Park CW AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Ohk, T G AU - Ohk TG AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Shin, M C AU - Shin MC AD - Kangwon National University, Chuncheonsi, South Korea. ISNI: 0000 0001 0707 9039. GRID: grid.412010.6 FAU - Marudi, A AU - Marudi A AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Baroni, S AU - Baroni S AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Gaspari, A AU - Gaspari A AD - University Modena, Modena, Italy. ISNI: 0000000121697570. GRID: grid.7548.e FAU - Bertellini, E AU - Bertellini E AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Orhun, G AU - Orhun G AD - Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey FAU - Senturk, E AU - Senturk E AD - Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey FAU - Ozcan, P E AU - Ozcan PE AD - Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey FAU - Sencer, S AU - Sencer S AD - Istanbul University, Medical Faculty of Istanbul, Department of Neuroradiology, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Ulusoy, C AU - Ulusoy C AD - Istanbul University, Institute of Experimental Medicine, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Tuzun, E AU - Tuzun E AD - Istanbul University, Institute of Experimental Medicine, Neuroscience, Istanbul, Turkey. ISNI: 0000 0001 2166 6619. GRID: grid.9601.e FAU - Esen, F AU - Esen F AD - Istanbul University, Medical Faculty of Istanbul, Anesthesiology and Intensive Care, Istanbul, Turkey FAU - Tincu, R AU - Tincu R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Cobilinschi, C AU - Cobilinschi C AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Tomescu, D AU - Tomescu D AD - Fundeni Clinical Institute, Bucharest, Romania. ISNI: 0000 0004 0540 9980. GRID: grid.415180.9 FAU - Ghiorghiu, Z AU - Ghiorghiu Z AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Macovei, R AU - Macovei R AD - Bucharest Clinical Emergency Hospital, Bucharest, Romania FAU - Van Assen, M AU - Van Assen M AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Admiraal, M M AU - Admiraal MM AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Putten, M J AU - Van Putten MJ AD - Medisch Spectrum Twente, Enschede, Netherlands. ISNI: 0000 0004 0399 8347. GRID: grid.415214.7 FAU - Tjepkema-Cloostermans, M AU - Tjepkema-Cloostermans M AD - Medisch Spectrum Twente, Enschede, Netherlands. ISNI: 0000 0004 0399 8347. GRID: grid.415214.7 FAU - Van Rootselaar, A F AU - Van Rootselaar AF AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Horn, J AU - Horn J AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Fallenius, M AU - Fallenius M AD - Helsinki University Hospital, Helsinki, Finland. ISNI: 0000 0000 9950 5666. GRID: grid.15485.3d FAU - Skrifvars, M B AU - Skrifvars MB AD - Helsinki University Hospital, Helsinki, Finland. ISNI: 0000 0000 9950 5666. GRID: grid.15485.3d FAU - Reinikainen, M AU - Reinikainen M AD - North Karelia Central Hospital, Joensuu, Finland. ISNI: 0000 0004 0368 0478. GRID: grid.416446.5 FAU - Bendel, S AU - Bendel S AD - Kuopio University Hospital, Kuopio, Finland. ISNI: 0000 0004 0628 207X. GRID: grid.410705.7 FAU - Raj, R AU - Raj R AD - Helsinki University Hospital, Helsinki, Finland. ISNI: 0000 0000 9950 5666. GRID: grid.15485.3d FAU - Abu-Habsa, M AU - Abu-Habsa M AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Hymers, C AU - Hymers C AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Borowska, A AU - Borowska A AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Sivadhas, H AU - Sivadhas H AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Sahiba, S AU - Sahiba S AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Perkins, S AU - Perkins S AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Rubio, J AU - Rubio J AD - Hospital Universitario Puerta del Mar, Cadiz, Spain. ISNI: 0000 0004 1771 1175. GRID: grid.411342.1 FAU - Rubio, J A AU - Rubio JA AD - Hospital Infanta Cristina, Badajoz, Spain. ISNI: 0000 0004 1771 0842. GRID: grid.411319.f FAU - Sierra, R AU - Sierra R AD - Hospital Universitario Puerta del Mar, Cadiz, Spain. ISNI: 0000 0004 1771 1175. GRID: grid.411342.1 FAU - English, S AU - English S AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Chasse, M AU - Chasse M AD - Ulaval, Quebec City, Canada FAU - Turgeon, A AU - Turgeon A AD - Ulaval, Quebec City, Canada FAU - Lauzier, F AU - Lauzier F AD - Ulaval, Quebec City, Canada FAU - Griesdale, D AU - Griesdale D AD - UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Garland, A AU - Garland A AD - UManitoba, Winnipeg, Canada FAU - Fergusson, D AU - Fergusson D AD - OHRI, Ottawa, Canada FAU - Zarychanski, R AU - Zarychanski R AD - UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Tinmouth, A AU - Tinmouth A AD - OHRI, Ottawa, Canada FAU - Van Walraven, C AU - Van Walraven C AD - OHRI, Ottawa, Canada FAU - Montroy, K AU - Montroy K AD - OHRI, Ottawa, Canada FAU - Ziegler, J AU - Ziegler J AD - UManitoba, Winnipeg, Canada FAU - Dupont Chouinard, R AU - Dupont Chouinard R AD - Ulaval, Quebec City, Canada FAU - Carignan, R AU - Carignan R AD - Ulaval, Quebec City, Canada FAU - Dhaliwal, A AU - Dhaliwal A AD - UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Lum, C AU - Lum C AD - OHRI, Ottawa, Canada FAU - Sinclair, J AU - Sinclair J AD - OHRI, Ottawa, Canada FAU - Pagliarello, G AU - Pagliarello G AD - OHRI, Ottawa, Canada FAU - McIntyre, L AU - McIntyre L AD - OHRI, Ottawa, Canada FAU - English, S AU - English S AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Chasse, M AU - Chasse M AD - Ulaval, Quebec City, Canada FAU - Turgeon, A AU - Turgeon A AD - Ulaval, Quebec City, Canada FAU - Lauzier, F AU - Lauzier F AD - Ulaval, Quebec City, Canada FAU - Griesdale, D AU - Griesdale D AD - UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Garland, A AU - Garland A AD - UManitoba, Winnipeg, Canada FAU - Fergusson, D AU - Fergusson D AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Zarychanski, R AU - Zarychanski R AD - UManitoba, Winnipeg, Canada FAU - Tinmouth, A AU - Tinmouth A AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Van Walraven, C AU - Van Walraven C AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Montroy, K AU - Montroy K AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Ziegler, J AU - Ziegler J AD - UManitoba, Winnipeg, Canada FAU - Dupont Chouinard, R AU - Dupont Chouinard R AD - Ulaval, Quebec City, Canada FAU - Carignan, R AU - Carignan R AD - Ulaval, Quebec City, Canada FAU - Dhaliwal, A AU - Dhaliwal A AD - UBC, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Lum, C AU - Lum C AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Sinclair, J AU - Sinclair J AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Pagliarello, G AU - Pagliarello G AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - McIntyre, L AU - McIntyre L AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Groza, T AU - Groza T AD - Cliniques St Luc, Université catholique de Louvain, Brussels, Belgium. ISNI: 0000 0001 2294 713X. GRID: grid.7942.8 FAU - Moreau, N AU - Moreau N AD - Cliniques St Luc, Université catholique de Louvain, Brussels, Belgium. ISNI: 0000 0001 2294 713X. GRID: grid.7942.8 FAU - Castanares-Zapatero, D AU - Castanares-Zapatero D AD - Cliniques St Luc, Université catholique de Louvain, Brussels, Belgium. ISNI: 0000 0001 2294 713X. GRID: grid.7942.8 FAU - Hantson, P AU - Hantson P AD - Cliniques St Luc, Université catholique de Louvain, Brussels, Belgium. ISNI: 0000 0001 2294 713X. GRID: grid.7942.8 FAU - Carbonara, M AU - Carbonara M AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Ortolano, F AU - Ortolano F AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Zoerle, T AU - Zoerle T AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Magnoni, S AU - Magnoni S AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Pifferi, S AU - Pifferi S AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Conte, V AU - Conte V AD - Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Stocchetti, N AU - Stocchetti N AD - Milan University, Milan, Italy. ISNI: 0000 0004 1757 2822. GRID: grid.4708.b FAU - Carteron, L AU - Carteron L AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Suys, T AU - Suys T AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Patet, C AU - Patet C AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Quintard, H AU - Quintard H AD - CHU de Nice, Nice, France. ISNI: 0000 0001 2322 4179. GRID: grid.410528.a FAU - Oddo, M AU - Oddo M AD - CHUV, Lausanne, Switzerland. ISNI: 0000 0001 0423 4662. GRID: grid.8515.9 FAU - Rubio, J A AU - Rubio JA AD - Hospital Infanta Cristina, Badajoz, Spain. ISNI: 0000 0004 1771 0842. GRID: grid.411319.f FAU - Rubio, J AU - Rubio J AD - Hospital Universitario Puerta del Mar, Cadiz, Spain. ISNI: 0000 0004 1771 1175. GRID: grid.411342.1 FAU - Sierra, R AU - Sierra R AD - Hospital Universitario Puerta del Mar, Cadiz, Spain. ISNI: 0000 0004 1771 1175. GRID: grid.411342.1 FAU - Spatenkova, V AU - Spatenkova V AD - Regional Hospital, Liberec, Czech Republic. ISNI: 0000 0004 0609 0449. GRID: grid.447961.9 FAU - Pokorna, E AU - Pokorna E AD - Institute of Experimental Medicine, Prague, Czech Republic. ISNI: 0000 0004 0404 6946. GRID: grid.424967.a FAU - Suchomel, P AU - Suchomel P AD - Regional Hospital, Liberec, Czech Republic. ISNI: 0000 0004 0609 0449. GRID: grid.447961.9 FAU - Ebert, N AU - Ebert N AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Jancik, J AU - Jancik J AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Rhodes, H AU - Rhodes H AD - Hennepin County Medical Center, Minneapolis, USA. ISNI: 0000 0000 9206 4546. GRID: grid.414021.2 FAU - Bylinski, T AU - Bylinski T AD - University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c FAU - Hawthorne, C AU - Hawthorne C AD - Institute of Neurological Sciences, NHSGGC, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Shaw, M AU - Shaw M AD - Department of Clinical Physics and Bioengineering, NHSGGC, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Piper, I AU - Piper I AD - Department of Clinical Physics and Bioengineering, NHSGGC, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Kinsella, J AU - Kinsella J AD - Academic Unit of Anaesthesia, Pain and Critical Care Medicine, University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c FAU - Kink, A K AU - Kink AK AD - Smartimplant Ltd., Tallinn, Estonia FAU - Rätsep, I R AU - Rätsep IR AD - NEMC, Tallinn, Estonia. ISNI: 0000 0004 0631 377X. GRID: grid.454953.a FAU - Boutin, A AU - Boutin A AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Moore, L AU - Moore L AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Chasse, M AU - Chasse M AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Zarychanski, R AU - Zarychanski R AD - University of Manitoba, Winnipeg, Canada. ISNI: 0000 0004 1936 9609. GRID: grid.21613.37 FAU - Lauzier, F AU - Lauzier F AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - English, S AU - English S AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - McIntyre, L AU - McIntyre L AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Lacroix, J AU - Lacroix J AD - Universite de Montreal, Montreal, Canada. ISNI: 0000 0001 2292 3357. GRID: grid.14848.31 FAU - Griesdale, D AU - Griesdale D AD - University of British Columbia, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Lessard-Bonaventure, P AU - Lessard-Bonaventure P AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Turgeon, A F AU - Turgeon AF AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Boutin, A AU - Boutin A AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Moore, L AU - Moore L AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Green, R AU - Green R AD - Dalhousie University, Halifax, Canada. ISNI: 0000 0004 1936 8200. GRID: grid.55602.34 FAU - Lessard-Bonaventure, P AU - Lessard-Bonaventure P AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Erdogan, M AU - Erdogan M AD - Dalhousie University, Halifax, Canada. ISNI: 0000 0004 1936 8200. GRID: grid.55602.34 FAU - Butler, M AU - Butler M AD - Dalhousie University, Halifax, Canada. ISNI: 0000 0004 1936 8200. GRID: grid.55602.34 FAU - Lauzier, F AU - Lauzier F AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Chasse, M AU - Chasse M AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - English, S AU - English S AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - McIntyre, L AU - McIntyre L AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Zarychanski, R AU - Zarychanski R AD - University of Manitoba, Winnipeg, Canada. ISNI: 0000 0004 1936 9609. GRID: grid.21613.37 FAU - Lacroix, J AU - Lacroix J AD - Universite de Montreal, Montreal, Canada. ISNI: 0000 0001 2292 3357. GRID: grid.14848.31 FAU - Griesdale, D AU - Griesdale D AD - University of British Columbia, Vancouver, Canada. ISNI: 0000 0001 2288 9830. GRID: grid.17091.3e FAU - Desjardins, P AU - Desjardins P AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Fergusson, D A AU - Fergusson DA AD - Ottawa Hospital Research Institute, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Turgeon, A F AU - Turgeon AF AD - Universite Laval, Quebec, Canada. ISNI: 0000 0004 1936 8390. GRID: grid.23856.3a FAU - Goncalves, B AU - Goncalves B AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Vidal, B AU - Vidal B AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Valdez, C AU - Valdez C AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Rodrigues, A C AU - Rodrigues AC AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Miguez, L AU - Miguez L AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Moralez, G AU - Moralez G AD - Hospital Estadual Getulio Vargas, Rio de Janeiro, Brazil FAU - Hong, T AU - Hong T AD - Yonsei University College of Medicine, Seoul, South Korea. ISNI: 0000 0004 0470 5454. GRID: grid.15444.30 FAU - Kutz, A AU - Kutz A AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Hausfater, P AU - Hausfater P AD - Emergency Department, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. ISNI: 0000 0001 2150 9058. GRID: grid.411439.a FAU - Amin, D AU - Amin D AD - Morton Plant Hospital, Clearwater, USA. ISNI: 0000 0000 8602 0133. GRID: grid.416123.3 FAU - Struja, T AU - Struja T AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Haubitz, S AU - Haubitz S AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Huber, A AU - Huber A AD - Department of Laboratory Medicine, Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Mueller, B AU - Mueller B AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schuetz, P AU - Schuetz P AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Brown, T AU - Brown T AD - Royal Cornwall Hospital Trust, Truro, UK. ISNI: 0000 0004 0474 4488. GRID: grid.412944.e FAU - Collinson, J AU - Collinson J AD - Royal Cornwall Hospital Trust, Truro, UK. ISNI: 0000 0004 0474 4488. GRID: grid.412944.e FAU - Pritchett, C AU - Pritchett C AD - Royal Cornwall Hospital Trust, Truro, UK. ISNI: 0000 0004 0474 4488. GRID: grid.412944.e FAU - Slade, T AU - Slade T AD - Royal Cornwall Hospital Trust, Truro, UK. ISNI: 0000 0004 0474 4488. GRID: grid.412944.e FAU - Le Guen, M AU - Le Guen M AD - Manchester Royal Infirmary, Manchester, UK. ISNI: 0000 0004 0641 2823. GRID: grid.419319.7 FAU - Hellings, S AU - Hellings S AD - Manchester Royal Infirmary, Manchester, UK. ISNI: 0000 0004 0641 2823. GRID: grid.419319.7 FAU - Ramsaran, R AU - Ramsaran R AD - Manchester Royal Infirmary, Manchester, UK. ISNI: 0000 0004 0641 2823. GRID: grid.419319.7 FAU - Alsheikhly, A AU - Alsheikhly A AD - Hamad Medical Corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Abe, T AU - Abe T AD - University of Tsukuba, Tsukuba Medical Center Hospital, Tsukuba, Japan. ISNI: 0000 0004 1764 0856. GRID: grid.417324.7 FAU - Kanapeckaite, L AU - Kanapeckaite L AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Abu-Habsa, M AU - Abu-Habsa M AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Bahl, R AU - Bahl R AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Russell, M Q AU - Russell MQ AD - Kent, Surrey & Sussex Air Ambulance Trust, Kent, UK FAU - Real, K J AU - Real KJ AD - Prometheus Delta-Tech, Herefordshire, UK FAU - Abu-Habsa, M AU - Abu-Habsa M AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Lyon, R M AU - Lyon RM AD - Kent, Surrey & Sussex Air Ambulance Trust, Kent, UK FAU - Oveland, N P AU - Oveland NP AD - Stavanger University Hospital, Stavanger, Norway. ISNI: 0000 0004 0627 2891. GRID: grid.412835.9 FAU - Penketh, J AU - Penketh J AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Mcdonald, M AU - Mcdonald M AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Kelly, F AU - Kelly F AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Alfafi, M AU - Alfafi M AD - Aseer Central Hospital, Abha, Saudi Arabia. ISNI: 0000 0004 0607 7156. GRID: grid.413974.c FAU - Alsolamy, S AU - Alsolamy S AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Almutairi, W AU - Almutairi W AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Alotaibi, B AU - Alotaibi B AD - King Fahad Medical City, Riyadh, Saudi Arabia. ISNI: 0000 0004 0593 1832. GRID: grid.415277.2 FAU - Van den Berg, A E AU - Van den Berg AE AD - HagaZiekenhuis, Den Haag, Netherlands. ISNI: 0000 0004 0568 6689. GRID: grid.413591.b FAU - Schriel, Y AU - Schriel Y AD - Reinier de Graaf Gasthuis, Delft, Netherlands. ISNI: 0000 0004 0624 5690. GRID: grid.415868.6 FAU - Dawson, L AU - Dawson L AD - Reinier de Graaf Gasthuis, Delft, Netherlands. ISNI: 0000 0004 0624 5690. GRID: grid.415868.6 FAU - Meynaar, I A AU - Meynaar IA AD - HagaZiekenhuis, Den Haag, Netherlands. ISNI: 0000 0004 0568 6689. GRID: grid.413591.b FAU - Talaie, H AU - Talaie H AD - Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. GRID: grid.411600.2 FAU - Silva, D AU - Silva D AD - Santa Maria University Hospital, Lisboa, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 FAU - Fernandes, S AU - Fernandes S AD - Santa Maria University Hospital, Lisboa, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 FAU - Gouveia, J AU - Gouveia J AD - Santa Maria University Hospital, Lisboa, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 FAU - Santos Silva, J AU - Santos Silva J AD - Santa Maria University Hospital, Lisboa, Portugal. ISNI: 0000 0001 2295 9747. GRID: grid.411265.5 FAU - Foley, J AU - Foley J AD - St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 FAU - Kaskovagheorgescu, A AU - Kaskovagheorgescu A AD - St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 FAU - Evoy, D AU - Evoy D AD - St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 FAU - Cronin, J AU - Cronin J AD - St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 FAU - Ryan, J AU - Ryan J AD - St. Vincent’s University Hospital, Dublin 4, Ireland. ISNI: 0000 0001 0315 8143. GRID: grid.412751.4 FAU - Huck, M AU - Huck M AD - Percy Military Teaching Hospital, Clamart, France FAU - Hoffmann, C AU - Hoffmann C AD - Percy Military Teaching Hospital, Clamart, France FAU - Renner, J AU - Renner J AD - Percy Military Teaching Hospital, Clamart, France FAU - Laitselart, P AU - Laitselart P AD - Percy Military Teaching Hospital, Clamart, France FAU - Donat, N AU - Donat N AD - Percy Military Teaching Hospital, Clamart, France FAU - Cirodde, A AU - Cirodde A AD - Percy Military Teaching Hospital, Clamart, France FAU - Schaal, J V AU - Schaal JV AD - Percy Military Teaching Hospital, Clamart, France FAU - Masson, Y AU - Masson Y AD - Percy Military Teaching Hospital, Clamart, France FAU - Nau, A AU - Nau A AD - Percy Military Teaching Hospital, Clamart, France FAU - Leclerc, T AU - Leclerc T AD - Percy Military Teaching Hospital, Clamart, France FAU - Howarth, O AU - Howarth O AD - Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Davenport, K AU - Davenport K AD - Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Jeanrenaud, P AU - Jeanrenaud P AD - Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Raftery, S AU - Raftery S AD - Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - MacTavish, P AU - MacTavish P AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Devine, H AU - Devine H AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - McPeake, J AU - McPeake J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Daniel, M AU - Daniel M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kinsella, J AU - Kinsella J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Quasim, T AU - Quasim T AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Alrabiee, S AU - Alrabiee S AD - King Abdulaziz Medical City, National Guard Hospital, Riyadh, Saudi Arabia. ISNI: 0000 0004 1790 7311. GRID: grid.415254.3 FAU - Alrashid, A AU - Alrashid A AD - Department of Management, College of Business Administration, King Saud University, Saudi Arabia, Riyadh, Saudi Arabia. ISNI: 0000 0004 1773 5396. GRID: grid.56302.32 FAU - Alsolamy, S AU - Alsolamy S AD - King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Gundogan, O AU - Gundogan O AD - Ege University Hospital, Izmir, Turkey. ISNI: 0000 0004 0535 6364. GRID: grid.412190.f FAU - Bor, C AU - Bor C AD - Ege University Hospital, Izmir, Turkey. ISNI: 0000 0004 0535 6364. GRID: grid.412190.f FAU - Akýn Korhan, E AU - Akýn Korhan E AD - Katip Celebi University, Health Sciences Faculty, Izmir, Turkey FAU - Demirag, K AU - Demirag K AD - Ege University Hospital, Izmir, Turkey. ISNI: 0000 0004 0535 6364. GRID: grid.412190.f FAU - Uyar, M AU - Uyar M AD - Ege University Hospital, Izmir, Turkey. ISNI: 0000 0004 0535 6364. GRID: grid.412190.f FAU - Frame, F AU - Frame F AD - Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK. GRID: grid.415667.7 FAU - Ashton, C AU - Ashton C AD - Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK. GRID: grid.415667.7 FAU - Bergstrom Niska, L AU - Bergstrom Niska L AD - Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK. GRID: grid.415667.7 FAU - Dilokpattanamongkol, P AU - Dilokpattanamongkol P AD - Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Suansanae, T AU - Suansanae T AD - Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Suthisisang, C AU - Suthisisang C AD - Faculty of Pharmacy, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Morakul, S AU - Morakul S AD - Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Karnjanarachata, C AU - Karnjanarachata C AD - Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Tangsujaritvijit, V AU - Tangsujaritvijit V AD - Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Mahmood, S AU - Mahmood S AD - Specialist Anesthesia, Doha, Qatar FAU - Al Thani, H AU - Al Thani H AD - Specialist Anesthesia, Doha, Qatar FAU - Almenyar, A AU - Almenyar A AD - Specialist Anesthesia, Doha, Qatar FAU - Vakalos, A AU - Vakalos A AD - Xanthi General Hospital, Xanthi, Greece FAU - Avramidis, V AU - Avramidis V AD - Xanthi General Hospital, Xanthi, Greece FAU - Sharvill, R AU - Sharvill R AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Penketh, J AU - Penketh J AD - Royal United Hospital, Bath, UK. ISNI: 0000 0004 0417 0728. GRID: grid.416091.b FAU - Morton, S E AU - Morton SE AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Chiew, Y S AU - Chiew YS AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Pretty, C AU - Pretty C AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Chase, J G AU - Chase JG AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Shaw, G M AU - Shaw GM AD - Christchurch Hospital, Christchurch, New Zealand. ISNI: 0000 0004 0614 1349. GRID: grid.414299.3 FAU - Knafelj, R AU - Knafelj R AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Kordis, P AU - Kordis P AD - Clinical Center Ljubljana, Ljubljana, Slovenia. ISNI: 0000 0004 0571 7705. GRID: grid.29524.38 FAU - Patel, S AU - Patel S AD - The Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f FAU - Grover, V AU - Grover V AD - The Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f FAU - Kuchyn, I AU - Kuchyn I AD - Bogomolets National Medical University, Kiev, Ukraine. GRID: grid.412081.e FAU - Bielka, K AU - Bielka K AD - Bogomolets National Medical University, Kiev, Ukraine. GRID: grid.412081.e FAU - Aidoni, Z AU - Aidoni Z AD - Aristotle Medical School, Thessaloniki, Greece FAU - Grosomanidis, V AU - Grosomanidis V AD - Aristotle Medical School, Thessaloniki, Greece FAU - Kotzampassi, K AU - Kotzampassi K AD - Aristotle Medical School, Thessaloniki, Greece FAU - Stavrou, G AU - Stavrou G AD - Aristotle Medical School, Thessaloniki, Greece FAU - Fyntanidou, B AU - Fyntanidou B AD - Aristotle Medical School, Thessaloniki, Greece FAU - Patsatzakis, S AU - Patsatzakis S AD - Aristotle Medical School, Thessaloniki, Greece FAU - Skourtis, C AU - Skourtis C AD - Aristotle Medical School, Thessaloniki, Greece FAU - Lee, S D AU - Lee SD AD - Royal Liverpool Intensive Care Unit, Liverpool, UK FAU - Williams, K AU - Williams K AD - Royal Liverpool Intensive Care Unit, Liverpool, UK FAU - Weltes, I D AU - Weltes ID AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - Berhane, S AU - Berhane S AD - Homerton University Hospital, London, UK. GRID: grid.439591.3 FAU - Arrowsmith, C AU - Arrowsmith C AD - Homerton University Hospital, London, UK. GRID: grid.439591.3 FAU - Peters, C AU - Peters C AD - Homerton University Hospital, London, UK. GRID: grid.439591.3 FAU - Robert, S AU - Robert S AD - Homerton University Hospital, London, UK. GRID: grid.439591.3 FAU - Caldas, J AU - Caldas J AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Panerai, R B AU - Panerai RB AD - University of Leicester, Leicester, UK. ISNI: 0000 0004 1936 8411. GRID: grid.9918.9 FAU - Robinson, T G AU - Robinson TG AD - University of Leicester, Leicester, UK. ISNI: 0000 0004 1936 8411. GRID: grid.9918.9 FAU - Camara, L AU - Camara L AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Ferreira, G AU - Ferreira G AD - University of Leicester, Leicester, UK. ISNI: 0000 0004 1936 8411. GRID: grid.9918.9 FAU - Borg-Seng-Shu, E AU - Borg-Seng-Shu E AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - De Lima Oliveira, M AU - De Lima Oliveira M AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Mian, N C AU - Mian NC AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Santos, L AU - Santos L AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Nogueira, R AU - Nogueira R AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Zeferino, S P AU - Zeferino SP AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Jacobsen Teixeira, M AU - Jacobsen Teixeira M AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Galas, F AU - Galas F AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Hajjar, L A AU - Hajjar LA AD - University of Sao Paulo, Sao Paulo, Brazil. ISNI: 0000 0004 1937 0722. GRID: grid.11899.38 FAU - Killeen, P AU - Killeen P AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - McPhail, M AU - McPhail M AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Bernal, W AU - Bernal W AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Maggs, J AU - Maggs J AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Wendon, J AU - Wendon J AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Hughes, T AU - Hughes T AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Taniguchi, L U AU - Taniguchi LU AD - Research and Education Institute, Sao Paulo, Brazil FAU - Siqueira, E M AU - Siqueira EM AD - Research and Education Institute, Sao Paulo, Brazil FAU - Vieira Jr, J M AU - Vieira Jr JM AD - Research and Education Institute, Sao Paulo, Brazil FAU - Azevedo, L C AU - Azevedo LC AD - Research and Education Institute, Sao Paulo, Brazil FAU - Ahmad, A N AU - Ahmad AN AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Abu-Habsa, M AU - Abu-Habsa M AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Bahl, R AU - Bahl R AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Helme, E AU - Helme E AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Hadfield, S AU - Hadfield S AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Loveridge, R AU - Loveridge R AD - King’s College Hospital, London, UK. ISNI: 0000 0004 0391 9020. GRID: grid.46699.34 FAU - Shak, J AU - Shak J AD - Ipswich Hospital NHS Trust, England, UK, Ipswich, UK. ISNI: 0000 0004 0413 7370. GRID: grid.412930.d FAU - Senver, C AU - Senver C AD - Ipswich Hospital NHS Trust, England, UK, Ipswich, UK. ISNI: 0000 0004 0413 7370. GRID: grid.412930.d FAU - Howard-Griffin, R AU - Howard-Griffin R AD - Ipswich Hospital NHS Trust, England, UK, Ipswich, UK. ISNI: 0000 0004 0413 7370. GRID: grid.412930.d FAU - Wacharasint, P AU - Wacharasint P AD - Phramongkutklao Hospital, Bangkok, Thailand. ISNI: 0000 0004 0576 1212. GRID: grid.414965.b FAU - Fuengfoo, P AU - Fuengfoo P AD - Phramongkutklao Hospital, Bangkok, Thailand. ISNI: 0000 0004 0576 1212. GRID: grid.414965.b FAU - Sukcharoen, N AU - Sukcharoen N AD - Phramongkutklao Hospital, Bangkok, Thailand. ISNI: 0000 0004 0576 1212. GRID: grid.414965.b FAU - Rangsin, R AU - Rangsin R AD - Phramongkutklao College of Medicine, Bangkok, Thailand. ISNI: 0000 0004 1937 0490. GRID: grid.10223.32 FAU - Sbiti-Rohr, D AU - Sbiti-Rohr D AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Schuetz, P AU - Schuetz P AD - Kantonsspital Aarau, Aarau, Switzerland. ISNI: 0000 0000 8704 3732. GRID: grid.413357.7 FAU - Na, H AU - Na H AD - Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 FAU - Song, S AU - Song S AD - Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 FAU - Lee, S AU - Lee S AD - Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 FAU - Jeong, E AU - Jeong E AD - Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 FAU - Lee, K AU - Lee K AD - Pusan National University Hospital, Busan, South Korea. ISNI: 0000 0000 8611 7824. GRID: grid.412588.2 FAU - Cooper, M AU - Cooper M AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Milinis, K AU - Milinis K AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - Williams, G AU - Williams G AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - McCarron, E AU - McCarron E AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Simants, S AU - Simants S AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Patanwala, I AU - Patanwala I AD - Royal Liverpool University Hospital, Liverpool, UK. ISNI: 0000 0004 0417 2395. GRID: grid.415970.e FAU - Welters, I D AU - Welters ID AD - University of Liverpool, Liverpool, UK. ISNI: 0000 0004 1936 8470. GRID: grid.10025.36 FAU - Zoumpelouli, E AU - Zoumpelouli E AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Volakli, E A AU - Volakli EA AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Chrysohoidou, V AU - Chrysohoidou V AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Georgiou, S AU - Georgiou S AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Charisopoulou, K AU - Charisopoulou K AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Kotzapanagiotou, E AU - Kotzapanagiotou E AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Panagiotidou, V AU - Panagiotidou V AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Manavidou, K AU - Manavidou K AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Stathi, Z AU - Stathi Z AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Sdougka, M AU - Sdougka M AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Salahuddin, N AU - Salahuddin N AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - AlGhamdi, B AU - AlGhamdi B AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Marashly, Q AU - Marashly Q AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Zaza, K AU - Zaza K AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Sharshir, M AU - Sharshir M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Khurshid, M AU - Khurshid M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Ali, Z AU - Ali Z AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Malgapo, M AU - Malgapo M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Jamil, M AU - Jamil M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Shafquat, A AU - Shafquat A AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Shoukri, M AU - Shoukri M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Hijazi, M AU - Hijazi M AD - King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. ISNI: 0000 0001 2191 4301. GRID: grid.415310.2 FAU - Abe, T AU - Abe T AD - The Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Uchino, S AU - Uchino S AD - The Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Takinami, M AU - Takinami M AD - The Jikei University School of Medicine, Tokyo, Japan. ISNI: 0000 0001 0661 2073. GRID: grid.411898.d FAU - Rangel Neto, N R AU - Rangel Neto NR AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Oliveira, S AU - Oliveira S AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Reis, F Q AU - Reis FQ AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Rocha, F A AU - Rocha FA AD - Albert Schweitzer State Hospital, Rio de Janeiro, Brazil FAU - Moralez, G AU - Moralez G AD - PPG Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ISNI: 0000 0001 2294 473X. GRID: grid.8536.8 FAU - Ebecken, K AU - Ebecken K AD - PPG Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ISNI: 0000 0001 2294 473X. GRID: grid.8536.8 FAU - Rabello, L S AU - Rabello LS AD - PPG Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. ISNI: 0000 0001 2294 473X. GRID: grid.8536.8 FAU - Lima, M F AU - Lima MF AD - Hospital Esperanca Recife, Recife, Brazil FAU - Hatum, R AU - Hatum R AD - Hospital Total Cor, Rio de Janeiro, Brazil FAU - De Marco, F V AU - De Marco FV AD - Hospital viValle, São José dos Campos, Brazil FAU - Alves, A AU - Alves A AD - Hospital Rios DOr, Rio de Janeiro, Brazil FAU - Pinto, J E AU - Pinto JE AD - Hospital Norte DOr, Rio de Janeiro, Brazil FAU - Godoy, M AU - Godoy M AD - Hospital Esperanca Olinda, Olinda, Brazil FAU - Brasil, P E AU - Brasil PE AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Bozza, F A AU - Bozza FA AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Salluh, J I AU - Salluh JI AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Soares, M AU - Soares M AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Krinsley, J AU - Krinsley J AD - Stamford Hospital, Stamford, USA. ISNI: 0000 0004 0377 0318. GRID: grid.416984.6 FAU - Kang, G AU - Kang G AD - Stamford Hospital, Stamford, USA. ISNI: 0000 0004 0377 0318. GRID: grid.416984.6 FAU - Perry, J AU - Perry J AD - Darent Valley Hospital, Dartford, UK. ISNI: 0000 0004 0398 7314. GRID: grid.413475.0 FAU - Hines, H AU - Hines H AD - William Harvey Hospital, Ashford, UK. ISNI: 0000 0004 0398 7998. GRID: grid.417122.3 FAU - Wilkinson, K M AU - Wilkinson KM AD - St James’s University Hospital, Leeds, UK. GRID: grid.443984.6 FAU - Tordoff, C AU - Tordoff C AD - St James’s University Hospital, Leeds, UK. GRID: grid.443984.6 FAU - Sloan, B AU - Sloan B AD - St James’s University Hospital, Leeds, UK. GRID: grid.443984.6 FAU - Bellamy, M C AU - Bellamy MC AD - St James’s University Hospital, Leeds, UK. GRID: grid.443984.6 FAU - Moreira, E AU - Moreira E AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Verga, F AU - Verga F AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Barbato, M AU - Barbato M AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Burghi, G AU - Burghi G AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Soares, M AU - Soares M AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Silva, U V AU - Silva UV AD - Hospital de Cancer de Barretos, Barretos, Brazil. ISNI: 0000 0004 0615 7498. GRID: grid.427783.d FAU - Azevedo, L C AU - Azevedo LC AD - Hospital Sírio Libanês, Sao Paulo, Brazil. ISNI: 0000 0000 9080 8521. GRID: grid.413471.4 FAU - Torelly, A P AU - Torelly AP AD - Sta. Casa de Porto Alegre, Porto Alegre, Brazil FAU - Kahn, J M AU - Kahn JM AD - University of Pittsburgh Medical Center, Pittsburgh, USA. ISNI: 0000 0001 0650 7433. GRID: grid.412689.0 FAU - Angus, D C AU - Angus DC AD - University of Pittsburgh Medical Center, Pittsburgh, USA. ISNI: 0000 0001 0650 7433. GRID: grid.412689.0 FAU - Knibel, M F AU - Knibel MF AD - Hospital Sao Lucas, Rio de Janeiro, Brazil FAU - Brasil, P E AU - Brasil PE AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Bozza, F A AU - Bozza FA AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Salluh, J I AU - Salluh JI AD - DOr Institute for Research and Education - IDOR, Rio de Janeiro, Brazil. GRID: grid.472984.4 FAU - Velasco, M B AU - Velasco MB AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Dalcomune, D M AU - Dalcomune DM AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Marshall, R AU - Marshall R AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Gilpin, T AU - Gilpin T AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Tridente, A AU - Tridente A AD - Whiston Hospital, St Helens & Knowsley, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Raithatha, A AU - Raithatha A AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Mota, D AU - Mota D AD - Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. ISNI: 0000000106861985. GRID: grid.28911.33 FAU - Loureiro, B AU - Loureiro B AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Dias, J AU - Dias J AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Afonso, O AU - Afonso O AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Coelho, F AU - Coelho F AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Martins, A AU - Martins A AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Faria, F AU - Faria F AD - Instituto Português de Oncologia Francisco Gil - Porto, Porto, Portugal. ISNI: 0000 0004 0631 0608. GRID: grid.418711.a FAU - Al-Dorzi, H AU - Al-Dorzi H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Al Orainni, H AU - Al Orainni H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - AlEid, F AU - AlEid F AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Tlaygeh, H AU - Tlaygeh H AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Itani, A AU - Itani A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Hejazi, A AU - Hejazi A AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Arabi, Y AU - Arabi Y AD - King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. ISNI: 0000 0004 0608 0662. GRID: grid.412149.b FAU - Gaudry, S AU - Gaudry S AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Messika, J AU - Messika J AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Ricard, J D AU - Ricard JD AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Guillo, S AU - Guillo S AD - Hôpital Bichat, Paris, France. ISNI: 0000 0000 8588 831X. GRID: grid.411119.d FAU - Pasquet, B AU - Pasquet B AD - Hôpital Bichat, Paris, France. ISNI: 0000 0000 8588 831X. GRID: grid.411119.d FAU - Dubief, E AU - Dubief E AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Dreyfuss, D AU - Dreyfuss D AD - Hôpital Louis Mourier, Colombes, France. ISNI: 0000 0001 0273 556X. GRID: grid.414205.6 FAU - Tubach, F AU - Tubach F AD - Hôpital Bichat, Paris, France. ISNI: 0000 0000 8588 831X. GRID: grid.411119.d FAU - Battle, C AU - Battle C AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - James, K AU - James K AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Temblett, P AU - Temblett P AD - Morriston Hospital, Swansea, UK. ISNI: 0000 0004 0649 0266. GRID: grid.416122.2 FAU - Davies, L AU - Davies L AD - Abertawe Bro Morgannwg University Health Board, Swansea, UK. ISNI: 0000 0000 8959 0182. GRID: grid.419728.1 FAU - Battle, C AU - Battle C AD - Abertawe Bro Morgannwg University Health Board, Swansea, UK. ISNI: 0000 0000 8959 0182. GRID: grid.419728.1 FAU - Lynch, C AU - Lynch C AD - Abertawe Bro Morgannwg University Health Board, Swansea, UK. ISNI: 0000 0000 8959 0182. GRID: grid.419728.1 FAU - Pereira, S AU - Pereira S AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Cavaco, S AU - Cavaco S AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Fernandes, J AU - Fernandes J AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Moreira, I AU - Moreira I AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Almeida, E AU - Almeida E AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Seabra Pereira, F AU - Seabra Pereira F AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Malheiro, M AU - Malheiro M AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Cardoso, F AU - Cardoso F AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Aragão, I AU - Aragão I AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Cardoso, T AU - Cardoso T AD - Centro Hospitalar Porto, Porto, Portugal. ISNI: 0000 0004 0392 7039. GRID: grid.418340.a FAU - Fister, M AU - Fister M AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Knafelj, R AU - Knafelj R AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Muraray Govind, P AU - Muraray Govind P AD - Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 FAU - Brahmananda Reddy, N AU - Brahmananda Reddy N AD - Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 FAU - Pratheema, R AU - Pratheema R AD - Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 FAU - Arul, E D AU - Arul ED AD - Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 FAU - Devachandran, J AU - Devachandran J AD - Apollo Speciality Hospital - OMR, Chennai, India. ISNI: 0000 0004 1802 3550. GRID: grid.413839.4 FAU - Velasco, M B AU - Velasco MB AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Dalcomune, D M AU - Dalcomune DM AD - Hospital Meridional S.A., Cariacica, Brazil FAU - Knafelj, R AU - Knafelj R AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Fister, M AU - Fister M AD - Rihard Knafelj, Ljubljana, Slovenia FAU - Chin-Yee, N AU - Chin-Yee N AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - D’Egidio, G AU - D’Egidio G AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Thavorn, K AU - Thavorn K AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Heyland, D AU - Heyland D AD - Kingston General Hospital, Kingston, Canada. ISNI: 0000 0004 0633 727X. GRID: grid.415354.2 FAU - Kyeremanteng, K AU - Kyeremanteng K AD - The Ottawa Hospital, Ottawa, Canada. ISNI: 0000 0000 9606 5108. GRID: grid.412687.e FAU - Murchison, A G AU - Murchison AG AD - Milton Keynes Hospital, Milton Keynes, UK. GRID: grid.415667.7 FAU - Swalwell, K AU - Swalwell K AD - Imperial College, London, UK. ISNI: 0000 0001 2113 8111. GRID: grid.7445.2 FAU - Mandeville, J AU - Mandeville J AD - Buckinghamshire Healthcare NHS Trust, Aylesbury, UK. ISNI: 0000 0004 0368 863X. GRID: grid.439664.a FAU - Stott, D AU - Stott D AD - Buckinghamshire Healthcare NHS Trust, Aylesbury, UK. ISNI: 0000 0004 0368 863X. GRID: grid.439664.a FAU - Guerreiro, I AU - Guerreiro I AD - IPO -Porto, Porto, Portugal. GRID: grid.435544.7 FAU - Devine, H AU - Devine H AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - MacTavish, P AU - MacTavish P AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - McPeake, J AU - McPeake J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Quasim, T AU - Quasim T AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kinsella, J AU - Kinsella J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Daniel, M AU - Daniel M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Goossens, C AU - Goossens C AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Marques, M B AU - Marques MB FAU - Derde, S AU - Derde S AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Vander Perre, S AU - Vander Perre S AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Dufour, T AU - Dufour T AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Thiessen, S E AU - Thiessen SE AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Güiza, F AU - Güiza F AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Janssens, T AU - Janssens T AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Hermans, G AU - Hermans G AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Vanhorebeek, I AU - Vanhorebeek I AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - De Bock, K AU - De Bock K AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Van den Berghe, G AU - Van den Berghe G AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Langouche, L AU - Langouche L AD - KU Leuven, Leuven, Belgium. ISNI: 0000 0001 0668 7884. GRID: grid.5596.f FAU - Devine, H AU - Devine H AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - MacTavish, P AU - MacTavish P AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Quasim, T AU - Quasim T AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kinsella, J AU - Kinsella J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Daniel, M AU - Daniel M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - McPeake, J AU - McPeake J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Miles, B AU - Miles B AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Madden, S AU - Madden S AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Devine, H AU - Devine H AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Weiler, M AU - Weiler M AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Marques, P AU - Marques P AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Rodrigues, C AU - Rodrigues C AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Boeira, M AU - Boeira M AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Brenner, K AU - Brenner K FAU - Leães, C AU - Leães C AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Machado, A AU - Machado A AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Townsend, R AU - Townsend R AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - Andrade, J AU - Andrade J AD - Ernesto Dornelles Hospital, Porto Alegre, Brazil FAU - MacTavish, P AU - MacTavish P AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - McPeake, J AU - McPeake J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Devine, H AU - Devine H AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kinsella, J AU - Kinsella J AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Daniel, M AU - Daniel M AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Kishore, R AU - Kishore R AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Fenlon, C AU - Fenlon C AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Quasim, T AU - Quasim T AD - Glasgow Royal Infirmary, Glasgow, UK. ISNI: 0000 0000 9825 7840. GRID: grid.411714.6 FAU - Fiks, T AU - Fiks T AD - Gelre Ziekenhuizen, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Ruijter, A AU - Ruijter A AD - Gelre Ziekenhuizen, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Te Raa, M AU - Te Raa M AD - Gelre Ziekenhuizen, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Spronk, P AU - Spronk P AD - Gelre Ziekenhuizen, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Chiew, Y S AU - Chiew YS AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Docherty, P AU - Docherty P AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Dickson, J AU - Dickson J AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Moltchanova, E AU - Moltchanova E AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Scarrot, C AU - Scarrot C AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Pretty, C AU - Pretty C AD - University of Canterbury, Christchurch, New Zealand. ISNI: 0000 0001 2179 1970. GRID: grid.21006.35 FAU - Shaw, G M AU - Shaw GM AD - Christchurch Hospital, Christchurch, New Zealand. ISNI: 0000 0004 0614 1349. GRID: grid.414299.3 FAU - Chase, J G AU - Chase JG AD - University of Western Ontario, London, Canada. ISNI: 0000 0004 1936 8884. GRID: grid.39381.30 FAU - Hall, T AU - Hall T AD - Surrey and Sussex NHS Trust, Redhill, UK FAU - Ngu, W C AU - Ngu WC AD - Surrey and Sussex NHS Trust, Redhill, UK FAU - Jack, J M AU - Jack JM AD - Surrey and Sussex NHS Trust, Redhill, UK FAU - Morgan, P AU - Morgan P AD - Surrey and Sussex NHS Trust, Redhill, UK FAU - Avard, B AU - Avard B AD - The Canberra Hospital, Hughes, ACT Australia. ISNI: 0000 0000 9984 5644. GRID: grid.413314.0 FAU - Pavli, A AU - Pavli A AD - The Canberra Hospital, Hughes, ACT Australia. ISNI: 0000 0000 9984 5644. GRID: grid.413314.0 FAU - Gee, X AU - Gee X AD - ANU Medical School, Canberra, Australia. ISNI: 0000 0001 2180 7477. GRID: grid.1001.0 FAU - Bor, C AU - Bor C AD - Ege University School of Medicine, Izmir, Turkey. ISNI: 0000 0001 1092 2592. GRID: grid.8302.9 FAU - Akin Korhan, E AU - Akin Korhan E AD - katip Celebi University, Izmir, Turkey. ISNI: 0000 0004 0454 9420. GRID: grid.411795.f FAU - Demirag, K AU - Demirag K AD - Ege University School of Medicine, Izmir, Turkey. ISNI: 0000 0001 1092 2592. GRID: grid.8302.9 FAU - Uyar, M AU - Uyar M AD - Ege University School of Medicine, Izmir, Turkey. ISNI: 0000 0001 1092 2592. GRID: grid.8302.9 FAU - Shirazy, M AU - Shirazy M AD - Alexandria University Faculty of medicine, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Fayed, A AU - Fayed A AD - Alexandria University Faculty of medicine, Alexandria, Egypt. ISNI: 0000 0001 2260 6941. GRID: grid.7155.6 FAU - Gupta, S AU - Gupta S AD - Fortis Escorts Heart Institute, New Delhi, India. ISNI: 0000 0004 1804 7827. GRID: grid.417966.b FAU - Kaushal, A AU - Kaushal A AD - Fortis Escorts Heart Institute, New Delhi, India. ISNI: 0000 0004 1804 7827. GRID: grid.417966.b FAU - Dewan, S AU - Dewan S FAU - Varma, A AU - Varma A AD - FMRI, Gurgaon, India. ISNI: 0000 0004 4653 2037. GRID: grid.464839.4 FAU - Ghosh, E AU - Ghosh E AD - Philips Research North America, Cambridge, USA. GRID: grid.417285.d FAU - Yang, L AU - Yang L AD - Philips Research North America, Cambridge, USA. GRID: grid.417285.d FAU - Eshelman, L AU - Eshelman L AD - Philips Research North America, Cambridge, USA. GRID: grid.417285.d FAU - Lord, B AU - Lord B AD - Philips Research North America, Cambridge, USA. GRID: grid.417285.d FAU - Carlson, E AU - Carlson E AD - Philips Research North America, Cambridge, USA. GRID: grid.417285.d FAU - Helme, E AU - Helme E AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Broderick, R AU - Broderick R AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Hadfield, S AU - Hadfield S AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Loveridge, R AU - Loveridge R AD - King’s College Hospital NHS Foundation Trust, London, UK. ISNI: 0000 0004 0489 4320. GRID: grid.429705.d FAU - Ramos, J AU - Ramos J AD - Hospital Sao Rafael, Salvador, Brazil. GRID: grid.413466.2 FAU - Forte, D AU - Forte D AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Yang, F AU - Yang F AD - Brigham and Women’s Hospital, Boston, USA. ISNI: 0000 0004 0378 8294. GRID: grid.62560.37 FAU - Hou, P AU - Hou P AD - Brigham and Women’s Hospital, Boston, USA. ISNI: 0000 0004 0378 8294. GRID: grid.62560.37 FAU - Dudziak, J AU - Dudziak J AD - St Helens and Knowsley, Liverpool, UK FAU - Feeney, J AU - Feeney J AD - St Helens and Knowsley, Liverpool, UK FAU - Wilkinson, K AU - Wilkinson K AD - St Helens and Knowsley, Liverpool, UK FAU - Bauchmuller, K AU - Bauchmuller K AD - STH, Sheffield, UK FAU - Shuker, K AU - Shuker K AD - STH, Sheffield, UK FAU - Faulds, M AU - Faulds M AD - STH, Sheffield, UK FAU - Raithatha, A AU - Raithatha A AD - STH, Sheffield, UK FAU - Bryden, D AU - Bryden D AD - STH, Sheffield, UK FAU - England, L AU - England L AD - St Helens and Knowsley, Liverpool, UK FAU - Bolton, N AU - Bolton N AD - St Helens and Knowsley, Liverpool, UK FAU - Tridente, A AU - Tridente A AD - St Helens and Knowsley, Liverpool, UK FAU - Bauchmuller, K AU - Bauchmuller K FAU - Shuker, K AU - Shuker K FAU - Tridente, A AU - Tridente A AD - Whiston Hospital, Prescot, UK. ISNI: 0000 0004 0417 1894. GRID: grid.417083.9 FAU - Faulds, M AU - Faulds M AD - Freeman Hospital, Newcastle upon Tyne, UK. ISNI: 0000 0004 0641 3308. GRID: grid.415050.5 FAU - Matheson, A AU - Matheson A AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Gaynor, J AU - Gaynor J FAU - Bryden, D AU - Bryden D CN - S South Yorkshire Hospitals Research Collaboration FAU - Ramos, J AU - Ramos J AD - Hospital Sao Rafael, Salvador, Brazil. GRID: grid.413466.2 FAU - Peroni, B AU - Peroni B AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Daglius-Dias, R AU - Daglius-Dias R AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Miranda, L AU - Miranda L AD - Hospital Nove de Julho, Sao Paulo, Brazil FAU - Cohen, C AU - Cohen C AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Carvalho, C AU - Carvalho C AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Velasco, I AU - Velasco I AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Forte, D AU - Forte D AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Kelly, J M AU - Kelly JM AD - University Hospital Coventry and Warwickshire, Coventry, UK. GRID: grid.15628.38 FAU - Neill, A AU - Neill A AD - Sunnybrook Health Sciences Centre, Toronto, Canada. ISNI: 0000 0000 9743 1587. GRID: grid.413104.3 FAU - Rubenfeld, G AU - Rubenfeld G AD - Sunnybrook Health Sciences Centre, Toronto, Canada. ISNI: 0000 0000 9743 1587. GRID: grid.413104.3 FAU - Masson, N AU - Masson N AD - NHS Scotland, Glasgow, UK. ISNI: 0000 0000 9506 6213. GRID: grid.422655.2 FAU - Min, A AU - Min A AD - Royal College of Surgeons of Ireland, Dublin, Ireland. ISNI: 0000 0004 0488 7120. GRID: grid.4912.e FAU - Boezeman, E AU - Boezeman E AD - University Leiden, Leiden, Netherlands. ISNI: 0000 0001 2312 1970. GRID: grid.5132.5 FAU - Hofhuis, J AU - Hofhuis J AD - Gelre Hospitals, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Hovingh, A AU - Hovingh A AD - Gelre Hospitals, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - De Vries, R AU - De Vries R AD - VU University Amsterdam, Amsterdam, Netherlands. ISNI: 0000 0004 1754 9227. GRID: grid.12380.38 FAU - Spronk, P AU - Spronk P AD - Gelre Hospitals, Apeldoorn, Netherlands. ISNI: 0000 0004 0370 4214. GRID: grid.415355.3 FAU - Cabral-Campello, G AU - Cabral-Campello G AD - Hospital de Santo António, Oporto Hospital Center, Porto, Portugal FAU - Aragão, I AU - Aragão I AD - Hospital de Santo António, Oporto Hospital Center, Porto, Portugal FAU - Cardoso, T AU - Cardoso T AD - Hospital de Santo António, Oporto Hospital Center, Porto, Portugal FAU - Van Mol, M AU - Van Mol M AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Nijkamp, M AU - Nijkamp M AD - Faculty of Psychology and Educational Sciences, Heerlen, Netherlands FAU - Kompanje, E AU - Kompanje E AD - Erasmus MC, Rotterdam, Netherlands. ISNI: 000000040459992X. GRID: grid.5645.2 FAU - Ostrowski, P AU - Ostrowski P AD - University of Toronto at Scarborough, Scarborough, ON Canada. ISNI: 0000 0001 2157 2938. GRID: grid.17063.33 FAU - Omar, A AU - Omar A AD - Hamad medical corporation, Doha, Qatar. ISNI: 0000 0004 0571 546X. GRID: grid.413548.f FAU - Kiss, K AU - Kiss K AD - University of Szeged, Szeged, Hungary. ISNI: 0000 0001 1016 9625. GRID: grid.9008.1 FAU - Köves, B AU - Köves B AD - Jahn Ferenc Hospital, Budapest, Hungary FAU - Csernus, V AU - Csernus V AD - University of Pécs, Pécs, Hungary. ISNI: 0000 0001 0663 9479. GRID: grid.9679.1 FAU - Molnár, Z AU - Molnár Z AD - University of Szeged, Szeged, Hungary. ISNI: 0000 0001 1016 9625. GRID: grid.9008.1 FAU - Hoydonckx, Y AU - Hoydonckx Y AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Vanwing, S AU - Vanwing S AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Stessel, B AU - Stessel B AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Van Assche, A AU - Van Assche A AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Jamaer, L AU - Jamaer L AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Dubois, J AU - Dubois J AD - Jessa Ziekenhuis, Hasselt, Belgium. ISNI: 0000 0004 0578 1096. GRID: grid.414977.8 FAU - Medo, V AU - Medo V AD - Hospital Clinico Universidad de Chile, Santiago, Chile. GRID: grid.412248.9 FAU - Galvez, R AU - Galvez R AD - Hospital Clinico Universidad de Chile, Santiago, Chile. GRID: grid.412248.9 FAU - Miranda, J P AU - Miranda JP AD - Hospital Clinico Universidad de Chile, Santiago, Chile. GRID: grid.412248.9 FAU - Stone, C AU - Stone C AD - Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f FAU - Wigmore, T AU - Wigmore T AD - Royal Marsden Hospital, London, UK. ISNI: 0000 0004 0417 0461. GRID: grid.424926.f FAU - Arunan, Y AU - Arunan Y AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Wheeler, A AU - Wheeler A AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Bauchmuller, K AU - Bauchmuller K AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Bryden, D AU - Bryden D AD - Sheffield Teaching Hospitals, Sheffield, UK. GRID: grid.419135.b FAU - Wong, Y AU - Wong Y AD - Tan Tock Seng hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Poi, C AU - Poi C FAU - Gu, C AU - Gu C AD - Tan Tock Seng hospital, Singapore, Singapore. GRID: grid.240988.f FAU - Molmy, P AU - Molmy P AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Van Grunderbeeck, N AU - Van Grunderbeeck N AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Nigeon, O AU - Nigeon O AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Lemyze, M AU - Lemyze M AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Thevenin, D AU - Thevenin D AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Mallat, J AU - Mallat J AD - Centre Hospitalier de Lens, Lens, France. ISNI: 0000 0004 0642 1236. GRID: grid.470048.f FAU - Ramos, J AU - Ramos J AD - Hospital Sao Rafael, Salvador, Brazil. GRID: grid.413466.2 FAU - Correa, M AU - Correa M AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Carvalho, R T AU - Carvalho RT AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Forte, D AU - Forte D AD - Hospital das Clinicas, Sao Paulo, Brazil. ISNI: 0000 0001 2297 2036. GRID: grid.411074.7 FAU - Fernandez, A AU - Fernandez A AD - Ntra Sra de Candelaria University Hospital, Santa Cruz de Tenerife, Spain FAU - McBride, C AU - McBride C AD - University of Texas at Austin, San Antonio, USA. ISNI: 0000 0004 1936 9924. GRID: grid.89336.37 FAU - Koonthalloor, E AU - Koonthalloor E AD - Beaumont Hospital, Dublin, Ireland. ISNI: 0000 0004 0617 6058. GRID: grid.414315.6 FAU - Walsh, C AU - Walsh C AD - Beaumont Hospital, Dublin, Ireland. ISNI: 0000 0004 0617 6058. GRID: grid.414315.6 FAU - Webber, A AU - Webber A AD - St Helens and Knowsley teaching hospitals, Liverpool, UK. GRID: grid.430747.3 FAU - Ashe, M AU - Ashe M AD - St Helens and Knowsley teaching hospitals, Liverpool, UK. GRID: grid.430747.3 FAU - Smith, K AU - Smith K AD - St Helens and Knowsley teaching hospitals, Liverpool, UK. GRID: grid.430747.3 FAU - Jeanrenaud, P AU - Jeanrenaud P AD - St Helens and Knowsley teaching hospitals, Liverpool, UK. GRID: grid.430747.3 FAU - Marudi, A AU - Marudi A AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Baroni, S AU - Baroni S AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Ragusa, F AU - Ragusa F AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Bertellini, E AU - Bertellini E AD - Nuovo Ospedale Civile Sant’Agostino Estense, Modena, Italy FAU - Volakli, E A AU - Volakli EA AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Chochliourou, E AU - Chochliourou E AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Dimitriadou, M AU - Dimitriadou M AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Violaki, A AU - Violaki A AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Mantzafleri, P AU - Mantzafleri P AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Samkinidou, E AU - Samkinidou E AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Vrani, O AU - Vrani O AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Arbouti, A AU - Arbouti A AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Varsami, T AU - Varsami T AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Sdougka, M AU - Sdougka M AD - PICU, Hippokration General Hospital, Thessaloniki, Greece. ISNI: 0000 0004 0621 2899. GRID: grid.414122.0 FAU - Bollen, J A AU - Bollen JA AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Van Smaalen, T C AU - Van Smaalen TC AD - Maastricht University Medical Center, Maastricht, Netherlands. GRID: grid.412966.e FAU - De Jongh, W C AU - De Jongh WC AD - Maastricht University Medical Center, Maastricht, Netherlands. GRID: grid.412966.e FAU - Ten Hoopen, M M AU - Ten Hoopen MM AD - Maastricht University, Maastricht, Netherlands. ISNI: 0000 0001 0481 6099. GRID: grid.5012.6 FAU - Ysebaert, D AU - Ysebaert D AD - University Hospital Antwerp, Edegem, Belgium. ISNI: 0000 0004 0626 3418. GRID: grid.411414.5 FAU - Van Heurn, L W AU - Van Heurn LW AD - Academic Medical Center, Amsterdam, Netherlands. ISNI: 0000000404654431. GRID: grid.5650.6 FAU - Van Mook, W N AU - Van Mook WN AD - Maastricht University Medical Center, Maastricht, Netherlands. GRID: grid.412966.e FAU - Sim, K AU - Sim K AD - St Helens and Knoowsley, Prescot, UK FAU - Fuller, A AU - Fuller A AD - St Helens and Knoowsley, Prescot, UK FAU - Roze des Ordons, A AU - Roze des Ordons A AD - University of Calgary, Calgary, Canada. ISNI: 0000 0004 1936 7697. GRID: grid.22072.35 FAU - Couillard, P AU - Couillard P AD - University of Calgary, Calgary, Canada. ISNI: 0000 0004 1936 7697. GRID: grid.22072.35 FAU - Doig, C AU - Doig C AD - University of Calgary, Calgary, Canada. ISNI: 0000 0004 1936 7697. GRID: grid.22072.35 FAU - Van Keer, R V AU - Van Keer RV AD - Vrije Universiteit Brussel, Brussel, Belgium. ISNI: 0000 0001 2290 8069. GRID: grid.8767.e FAU - Deschepper, R D AU - Deschepper RD AD - Vrije Universiteit Brussel, Brussel, Belgium. ISNI: 0000 0001 2290 8069. GRID: grid.8767.e FAU - Francke, A F AU - Francke AF AD - EMGO+/VU University medical center, Utrecht, Netherlands. ISNI: 0000000090126352. GRID: grid.7692.a FAU - Huyghens, L H AU - Huyghens LH AD - Universitair Ziekenhuis Brussel, Brussel, Belgium. ISNI: 0000 0004 0626 3362. GRID: grid.411326.3 FAU - Bilsen, J B AU - Bilsen JB AD - Vrije Universiteit Brussel, Brussel, Belgium. ISNI: 0000 0001 2290 8069. GRID: grid.8767.e FAU - Nyamaizi, B AU - Nyamaizi B AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Dalrymple, C AU - Dalrymple C AD - Queen Elizabeth Hospital, London, UK. GRID: grid.439484.6 FAU - Molokhia, A AU - Molokhia A AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Dobru, A AU - Dobru A AD - University Hospital Lewisham, London, UK. GRID: grid.439787.6 FAU - Marrinan, E AU - Marrinan E AD - Lewisham & Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Ankuli, A AU - Ankuli A AD - Lewisham & Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - Molokhia, A AU - Molokhia A AD - Lewisham & Greenwich NHS Trust, London, UK. GRID: grid.429537.e FAU - McPeake, J AU - McPeake J AD - University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c FAU - Struthers, R AU - Struthers R AD - NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Crawford, R AU - Crawford R AD - NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Devine, H AU - Devine H AD - NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Mactavish, P AU - Mactavish P AD - NHS Greater Glasgow and Clyde, Glasgow, UK. ISNI: 0000 0001 0523 9342. GRID: grid.413301.4 FAU - Quasim, T AU - Quasim T AD - University of Glasgow, Glasgow, UK. ISNI: 0000 0001 2193 314X. GRID: grid.8756.c FAU - Morelli, P AU - Morelli P AD - National Burn Unit, Montevideo, Uruguay FAU - Degiovanangelo, M AU - Degiovanangelo M AD - National Burn Unit, Montevideo, Uruguay FAU - Lemos, F AU - Lemos F AD - National Burn Unit, Montevideo, Uruguay FAU - MArtinez, V AU - MArtinez V AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Verga, F AU - Verga F AD - National Burn Unit, Montevideo, Uruguay FAU - Cabrera, J AU - Cabrera J AD - National Burn Unit, Montevideo, Uruguay FAU - Burghi, G AU - Burghi G AD - Hospital Maciel, Montevideo, Uruguay. GRID: grid.414794.b FAU - Rutten, A AU - Rutten A AD - St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Van Ieperen, S AU - Van Ieperen S AD - St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 FAU - De Geer, S AU - De Geer S AD - St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Van Vugt, M AU - Van Vugt M AD - St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Der Kinderen, E AU - Der Kinderen E AD - St Elisabeth Ziekenhuis, Tilburg, Netherlands. GRID: grid.416373.4 FAU - Giannini, A AU - Giannini A AD - Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Miccinesi, G AU - Miccinesi G AD - Istituto per lo Studio e la Prevenzione Oncologica, Florence, Italy. ISNI: 0000 0004 1758 0566. GRID: grid.417623.5 FAU - Marchesi, T AU - Marchesi T AD - Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 FAU - Prandi, E AU - Prandi E AD - Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, Milan, Italy. ISNI: 0000 0004 1757 8749. GRID: grid.414818.0 LA - eng PT - Congress DEP - 20160420 PL - England TA - Crit Care JT - Critical care (London, England) JID - 9801902 EIN - Crit Care. 2016 Oct 24;20:347. doi: 10.1186/s13054-016-1358-6. PMID: 31268434 PMC - PMC5493079 EDAT- 2016/11/26 06:00 MHDA- 2016/11/26 06:01 PMCR- 2016/04/20 CRDT- 2016/11/26 06:00 PHST- 2016/11/26 06:00 [entrez] PHST- 2016/11/26 06:00 [pubmed] PHST- 2016/11/26 06:01 [medline] PHST- 2016/04/20 00:00 [pmc-release] AID - 10.1186/s13054-016-1208-6 [pii] AID - 1208 [pii] AID - 10.1186/s13054-016-1208-6 [doi] PST - epublish SO - Crit Care. 2016 Apr 20;20(Suppl 2):94. doi: 10.1186/s13054-016-1208-6. PMID- 2700138 OWN - NLM STAT- MEDLINE DCOM- 19900717 LR - 20191029 IS - 0950-3552 (Print) IS - 0950-3552 (Linking) VI - 3 IP - 4 DP - 1989 Dec TI - Premenstrual syndrome. PG - 687-704 AB - The term premenstrual syndrome is often used to describe several clinical conditions. Only a full history covering not only reproductive but also psychological and social factors, combined with daily diaries which are kept prospectively for at least two months, can help clarify the problems the patient experiences. As it is the timing rather than the type of symptoms which is essential to a diagnosis, diaries are used to assess symptoms, make a diagnosis and monitor the effectiveness of therapy. Patients with premenstrual syndrome should therefore always keep a diary and bring it to every consultation. We do not know if patients complaining of premenstrual syndrome are at one extreme of a spectrum disorder or if they are a 'specific group'. Such patients may have classical premenstrual syndrome, perimenstrual distress, benign idiopathic oedema, dysmenorrhoea, cyclical benign breast disease or mood symptoms which are not significantly related to the menstrual cycle. There are many aetiological theories--biological, psychological, environmental and social, the syndrome being a complex psychosomatic disorder. For appropriate management an accurate diagnostic formation is required. Reassurance, stress management techniques, an improvement in general mental and physical well-being, information and education are the mainstays of therapy. Symptomatic relief of symptoms is often helpful. Many other managements have been tried with the aim of correcting the underlying aetiological case. These include vitamins, prostaglandin inhibitors and endocrine therapies. As the disorder is long-term, the safety of treatments should be carefully considered. FAU - Sampson, G A AU - Sampson GA LA - eng PT - Journal Article PT - Review PL - England TA - Baillieres Clin Obstet Gynaecol JT - Bailliere's clinical obstetrics and gynaecology JID - 8710782 SB - IM MH - Female MH - Humans MH - *Premenstrual Syndrome/psychology RF - 67 EDAT- 1989/12/01 00:00 MHDA- 1989/12/01 00:01 CRDT- 1989/12/01 00:00 PHST- 1989/12/01 00:00 [pubmed] PHST- 1989/12/01 00:01 [medline] PHST- 1989/12/01 00:00 [entrez] AID - 10.1016/s0950-3552(89)80060-4 [doi] PST - ppublish SO - Baillieres Clin Obstet Gynaecol. 1989 Dec;3(4):687-704. doi: 10.1016/s0950-3552(89)80060-4. PMID- 25735611 OWN - NLM STAT- MEDLINE DCOM- 20180507 LR - 20220316 IS - 1752-8526 (Electronic) VI - 2015 DP - 2015 Mar 4 TI - Bulimia nervosa: online interventions. LID - 1009 [pii] AB - INTRODUCTION: Up to 1% of people in the community may have bulimia nervosa, characterised by an intense preoccupation with body weight, binge-eating episodes, and use of extreme measures to counteract the feared effects of overeating. People with bulimia nervosa are of normal weight or are overweight, making the condition distinct from anorexia nervosa. After 10 years, about half of people with bulimia nervosa will have recovered fully, one third will have made a partial recovery, and 10% to 20% will still have symptoms. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of online interventions for people with bulimia nervosa? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found eight studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: applications (apps) or online programmes used as an adjunct to face-to-face therapy, delivery of self-help online, and delivery of therapy online. FAU - Hay, Phillipa J AU - Hay PJ AD - School of Medicine, Campbelltown Campus, Western Sydney University, Sydney, Australia. FAU - Claudino, Angélica Medeiros AU - Claudino AM LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20150304 PL - England TA - BMJ Clin Evid JT - BMJ clinical evidence JID - 101294314 SB - IM MH - Bulimia Nervosa/*therapy MH - Humans MH - *Internet MH - Psychology, Clinical/*methods MH - Psychotherapy/*instrumentation MH - Treatment Outcome PMC - PMC4356174 EDAT- 2015/03/05 06:00 MHDA- 2018/05/08 06:00 PMCR- 2017/03/04 CRDT- 2015/03/05 06:00 PHST- 2015/03/05 06:00 [entrez] PHST- 2015/03/05 06:00 [pubmed] PHST- 2018/05/08 06:00 [medline] PHST- 2017/03/04 00:00 [pmc-release] AID - 1009 [pii] PST - epublish SO - BMJ Clin Evid. 2015 Mar 4;2015:1009. PMID- 17009570 OWN - NLM STAT- MEDLINE DCOM- 20061103 LR - 20061002 IS - 1497-3715 (Print) IS - 1497-3715 (Linking) VI - 17 IP - 3 DP - 2006 Fall TI - To err is human, to share is divine. PG - 22-5 AB - Front-line health care practitioners are often safety nets preventing errors from reaching patients. Nurses in critical care environments commonly deal with high-risk patients, high-alert medications and extreme conditions, placing themselves and medication systems under greater pressures. Human error cannot be eradicated. However, the systems in which practitioners work and interact can be made safer and more fault-tolerant. When errors occur, nurses are in a unique position to provide valuable insights. Practitioner reporting and sharing of incident information internally and externally can enhance patient safety by helping to prevent recurrence of similar events. FAU - Koczmara, Christine AU - Koczmara C AD - ISMP Canada. FAU - Dueck, Carol AU - Dueck C FAU - Jelincic, Valentina AU - Jelincic V LA - eng PT - Journal Article PT - Review PL - Canada TA - Dynamics JT - Dynamics (Pembroke, Ont.) JID - 100955578 MH - Adverse Drug Reaction Reporting Systems MH - Canada MH - Causality MH - Cooperative Behavior MH - Critical Care/*organization & administration MH - Databases, Factual MH - Documentation MH - Drug Labeling MH - Drug Packaging MH - Humans MH - Information Dissemination MH - Medication Errors/methods/*nursing/*prevention & control/statistics & numerical data MH - *Nurse's Role/psychology MH - Nursing Staff, Hospital/*organization & administration/psychology MH - Risk Management/*organization & administration MH - Systems Analysis RF - 31 EDAT- 2006/10/03 09:00 MHDA- 2006/11/04 09:00 CRDT- 2006/10/03 09:00 PHST- 2006/10/03 09:00 [pubmed] PHST- 2006/11/04 09:00 [medline] PHST- 2006/10/03 09:00 [entrez] PST - ppublish SO - Dynamics. 2006 Fall;17(3):22-5. PMID- 38783823 OWN - NLM STAT- MEDLINE DCOM- 20240524 LR - 20240529 IS - 1096-9071 (Electronic) IS - 0146-6615 (Linking) VI - 96 IP - 6 DP - 2024 Jun TI - Global and regional burden of vaccine-associated facial paralysis, 1967-2023: Findings from the WHO international pharmacovigilance database. PG - e29682 LID - 10.1002/jmv.29682 [doi] AB - The scarce and conflicting data on vaccine-associated facial paralysis limit our understanding of vaccine safety on a global scale. Therefore, this study aims to evaluate the global burden of vaccine-associated facial paralysis and to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health Organization International Pharmacovigilance Database. Global reporting counts, reported odds ratios (ROR), and information components (ICs) were computed to elucidate the association between the 16 vaccines and the occurrence of vaccine-associated facial paralysis across 156 countries. We identified 26 197 reports (men, n = 10 507 [40.11%]) of vaccine-associated facial paralysis from 49 537 reports of all-cause facial paralysis. Vaccine-associated facial paralysis has been consistently reported; however, a pronounced increase in reported incidence has emerged after the onset of the coronavirus disease 2019 (COVID-19) pandemic, which is attributable to the COVID-19 mRNA vaccine. Most vaccines were associated with facial paralysis, with differing levels of association, except for tuberculosis vaccines. COVID-19 mRNA vaccines had the highest association with facial paralysis reports (ROR, 28.31 [95% confidence interval, 27.60-29.03]; IC, 3.37 [IC(0.25), 3.35]), followed by encephalitis, influenza, hepatitis A, papillomavirus, hepatitis B, typhoid, varicella-zoster, meningococcal, Ad-5 vectored COVID-19, measles, mumps and rubella, diphtheria, tetanus toxoids, pertussis, polio, and Hemophilus influenza type b, pneumococcal, rotavirus diarrhea, and inactivated whole-virus COVID-19 vaccines. Concerning age- and sex-specific risks, vaccine-associated facial paralysis was more strongly associated with older age groups and males. The serious adverse outcome and death rate of vaccine-associated facial paralysis were extremely low (0.07% and 0.00%, respectively). An increase in vaccine-induced facial paralysis, primarily owing to COVID-19 mRNA vaccines, was observed with most vaccines, except tuberculosis vaccines. Given the higher association observed in the older and male groups with vaccine-associated facial paralysis, close monitoring of these demographics when administering vaccines that are significantly associated with adverse reactions is crucial. CI - © 2024 Wiley Periodicals LLC. FAU - Jeong, Yi Deun AU - Jeong YD AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Lee, Kyeongmin AU - Lee K AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Lee, Sooji AU - Lee S AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Park, Jaeyu AU - Park J AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Kim, Hyeon Jin AU - Kim HJ AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Lee, Jinseok AU - Lee J AD - Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea. FAU - Kang, Jiseung AU - Kang J AD - Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Jacob, Louis AU - Jacob L AD - Department of Physical Medicine and Rehabilitation, AP-HP, Université Paris Cité, Lariboisière-Fernand Widal Hospital, Paris, France. AD - Epidemiology of Ageing and Neurodegenerative Diseases (EpiAgeing), Université Paris Cité, Inserm U1153, Paris, France. AD - Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, ISCIII, Barcelona, Spain. FAU - Smith, Lee AU - Smith L AD - Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK. FAU - Rahmati, Masoud AU - Rahmati M AD - Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran. AD - Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran. AD - Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France. FAU - López Sánchez, Guillermo F AU - López Sánchez GF AD - Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain. FAU - Dragioti, Elena AU - Dragioti E AD - Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. AD - Research Laboratory Psychology of Patients, Families, and Health Professionals, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece. FAU - Son, Yejun AU - Son Y AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Soeun AU - Kim S AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Yeo, Seung Geun AU - Yeo SG AD - Department of Otolaryngology-Head & Neck Surgery, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Lee, Hayeon AU - Lee H AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. LA - eng GR - RS-2023-00248157/National Research Foundation of Korea/ PT - Journal Article PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 RN - 0 (Vaccines) SB - IM MH - Humans MH - *Facial Paralysis/epidemiology/etiology MH - *Pharmacovigilance MH - Male MH - *World Health Organization MH - Female MH - Adult MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Databases, Factual MH - Child MH - Child, Preschool MH - Aged MH - Incidence MH - Vaccines/adverse effects MH - Global Health MH - COVID-19/prevention & control/epidemiology MH - Infant MH - Vaccination/adverse effects/statistics & numerical data MH - SARS-CoV-2/immunology OTO - NOTNLM OT - World Health Organization OT - facial paralysis OT - global OT - vaccine OT - vaccine‐associated facial paralysis EDAT- 2024/05/24 06:42 MHDA- 2024/05/24 06:43 CRDT- 2024/05/24 03:33 PHST- 2024/04/16 00:00 [revised] PHST- 2024/03/14 00:00 [received] PHST- 2024/05/08 00:00 [accepted] PHST- 2024/05/24 06:43 [medline] PHST- 2024/05/24 06:42 [pubmed] PHST- 2024/05/24 03:33 [entrez] AID - 10.1002/jmv.29682 [doi] PST - ppublish SO - J Med Virol. 2024 Jun;96(6):e29682. doi: 10.1002/jmv.29682. PMID- 37280014 OWN - NLM STAT- MEDLINE DCOM- 20240920 LR - 20241027 IS - 2633-3775 (Electronic) IS - 2633-3767 (Print) IS - 2633-3767 (Linking) VI - 170 IP - 5 DP - 2024 Sep 20 TI - Peer-based intervention for acute stress reaction: adaptations by five militaries. PG - 425-429 LID - 10.1136/military-2022-002344 [doi] LID - e002344 AB - Military service members need to be able to operate under conditions of extreme stress to ensure the success of their team's mission; however, an acute stress reaction (ASR) can compromise team safety and effectiveness by rendering an individual unable to function. Building on an intervention originally developed by the Israel Defense Forces, several countries have developed, tested, and disseminated a peer-based intervention to help service members manage acute stress in others. This paper reviews how five countries (Canada, Germany, Norway, the UK and the USA) adjusted the protocol to fit their organisational culture while retaining essential elements of the original procedure, suggesting there can be interoperability and mutual intelligibility in the management of ASR by military allies. Future research should examine the parameters of effectiveness for this intervention, the impact of intervention on long-term trajectories, and individual differences in managing ASR. CI - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Adler, Amy B AU - Adler AB AUID- ORCID: 0000-0002-0886-5530 AD - Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA amy.b.adler.civ@health.mil. FAU - Gutierrez, I A AU - Gutierrez IA AUID- ORCID: 0000-0002-4880-7570 AD - Research Transition Office, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA. FAU - McCuaig Edge, H AU - McCuaig Edge H AUID- ORCID: 0009-0000-7195-0810 AD - Director General Military Personnel Research and Analysis, National Defence, Ottawa, Ontario, Canada. FAU - Nordstrand, A E AU - Nordstrand AE AUID- ORCID: 0000-0002-2012-0574 AD - Norwegian Armed Forces, Joint Medical Services, Oslo, Norway. FAU - Simms, A AU - Simms A AUID- ORCID: 0000-0002-1154-8085 AD - Academic Department of Military Mental Health, King's College London, London, UK. FAU - Willmund, G D AU - Willmund GD AD - Centre for Psychiatry and Psychotraumatology, Bundeswehrkrankenhaus Berlin, Berlin, Germany. LA - eng PT - Journal Article PT - Review DEP - 20240920 PL - England TA - BMJ Mil Health JT - BMJ military health JID - 101761581 SB - IM MH - Humans MH - *Military Personnel/psychology MH - *Peer Group MH - Canada MH - United Kingdom MH - Germany MH - Norway MH - United States MH - Stress, Psychological/therapy/psychology PMC - PMC11503197 OTO - NOTNLM OT - EDUCATION & TRAINING (see Medical Education & Training) OT - MENTAL HEALTH OT - TRAUMA MANAGEMENT COIS- Competing interests: None declared. EDAT- 2023/06/07 01:07 MHDA- 2024/09/21 16:19 PMCR- 2024/10/25 CRDT- 2023/06/06 20:42 PHST- 2023/01/03 00:00 [received] PHST- 2023/05/01 00:00 [accepted] PHST- 2024/09/21 16:19 [medline] PHST- 2023/06/07 01:07 [pubmed] PHST- 2023/06/06 20:42 [entrez] PHST- 2024/10/25 00:00 [pmc-release] AID - military-2022-002344 [pii] AID - 10.1136/military-2022-002344 [doi] PST - epublish SO - BMJ Mil Health. 2024 Sep 20;170(5):425-429. doi: 10.1136/military-2022-002344. PMID- 27572854 OWN - NLM STAT- MEDLINE DCOM- 20170518 LR - 20220316 IS - 1526-632X (Electronic) IS - 0028-3878 (Linking) VI - 87 IP - 9 Suppl 2 DP - 2016 Aug 30 TI - Pediatric multiple sclerosis: Escalation and emerging treatments. PG - S103-9 LID - 10.1212/WNL.0000000000002884 [doi] AB - Over the last 20 years, there have been significant advances in multiple sclerosis (MS) therapeutics, with regulatory approval for 13 therapies in adults by the European Medicines Agency (EMA) and Food and Drug Administration. However, there is only limited approval for interferon-β and glatiramer acetate use in children 12 years and older by the EMA. Availability of disease-modifying therapies to children and adolescents with MS is variable by region, and is extremely limited in some regions of the world. Up to 30% of children experience breakthrough disease requiring therapies beyond traditional first-line agents. Recent legislation in both the United States and Europe has mandated clinical studies for all new therapeutics applicable to children. Several clinical trials in children are underway that will provide important information regarding the efficacy and safety of newer drugs. This review summarizes the current knowledge of breakthrough disease, escalation, and induction treatment approaches in children with MS, especially pertaining to disease course and disability outcomes in this group of patients. In addition, ongoing clinical trials and approaches and challenges in conducting clinical trials in the pediatric population are discussed. CI - © 2016 American Academy of Neurology. FAU - Chitnis, Tanuja AU - Chitnis T AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. tchitnis@partners.org. FAU - Ghezzi, Angelo AU - Ghezzi A AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. FAU - Bajer-Kornek, Barbara AU - Bajer-Kornek B AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. FAU - Boyko, Alexey AU - Boyko A AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. FAU - Giovannoni, Gavin AU - Giovannoni G AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. FAU - Pohl, Daniela AU - Pohl D AD - From Partners Pediatric MS Center (T.C.), Massachusetts General Hospital, Harvard Medical School, Boston; Divisione di Neurologia 2-Centro Studi Sclerosi Multipla (A.G.), Ospedale di Gallarate, Italy; Department of Neurology (B.B.-K.), Medical University of Vienna, Austria; Department of Neurology, Neurosurgery and Medical Genetics (A.B.), Pirogov's Russian National Research Medical University, Moscow; Barts and The London School of Medicine and Dentistry (G.G.), London, UK; and Department of Neurology (D.P.), Children's Hospital of Eastern Ontario, University of Ottawa, Canada. LA - eng PT - Journal Article PT - Review PL - United States TA - Neurology JT - Neurology JID - 0401060 RN - 0 (Immunologic Factors) SB - IM MH - Child MH - Clinical Trials as Topic MH - Humans MH - Immunologic Factors/*therapeutic use MH - Multiple Sclerosis/*drug therapy/psychology MH - *Pediatrics MH - Treatment Outcome MH - United States MH - United States Food and Drug Administration EDAT- 2016/08/31 06:00 MHDA- 2017/05/19 06:00 CRDT- 2016/08/31 06:00 PHST- 2015/08/19 00:00 [received] PHST- 2016/02/18 00:00 [accepted] PHST- 2016/08/31 06:00 [entrez] PHST- 2016/08/31 06:00 [pubmed] PHST- 2017/05/19 06:00 [medline] AID - WNL.0000000000002884 [pii] AID - 10.1212/WNL.0000000000002884 [doi] PST - ppublish SO - Neurology. 2016 Aug 30;87(9 Suppl 2):S103-9. doi: 10.1212/WNL.0000000000002884. PMID- 23293051 OWN - NLM STAT- MEDLINE DCOM- 20131017 LR - 20130411 IS - 1520-6394 (Electronic) IS - 1091-4269 (Linking) VI - 30 IP - 4 DP - 2013 Apr TI - Treatment of depression in cardiovascular disease. PG - 328-41 LID - 10.1002/da.22051 [doi] AB - BACKGROUND AND OBJECTIVES: Depression in patients with Cardiovascular Disease (CVD) is extremely common, with a prevalence of 17-47%, and is associated with increased risk of morbidity and mortality. Treatment of depression has been hypothesized to reduce cardiac mortality. Pharmacologic and psychotherapeutic interventions have been studied and appear to be safe and in some studies effective in reducing depressive symptoms in patients with cardiac disease. The impact on cardiac outcomes remains unclear. This review briefly focuses on the prevalence of depression in patients with CVD, the physiological links between depression and CVD, and largely is concerned with the clinical trials that seek to demonstrate efficacy and safety of antidepressant medications and psychotherapy in this patient population. METHODS: PubMed and PsycINFO databases were searched through July 2012. Publications were included if they were in English, a review article, or a clinical trial in the CVD population with comorbid depression. The search was completed with key words of antidepressants, CVD, coronary artery syndrome, SSRIs, depression, treatment of depression, post-MI (where MI is myocardial infarction), major depression, and cardiac disease. Trials were included if the patients were above the age of 18, both male and female genders, and had cardiac comorbidity. No trials were excluded. RESULTS: A total of 61 articles and/or book chapters were included. The majority were from North America and Europe. There were 7 clinical trials of tricyclic antidepressants (TCAs), one of TCAs and bupropion, and 10 trials of selective serotonin reuptake inhibitors (SSRIs). We also evaluated five trials involving psychotherapeutic techniques and/or collaborative care. CONCLUSIONS: There is considerable evidence from randomized controlled clinical trials that antidepressants, especially SSRIs, are safe in the treatment of major depression in patients with CVD. Although efficacy has been demonstrated in some, but not all, trials for both antidepressants and certain psychotherapies, large, well-powered trials are urgently needed. There are virtually no data available on predictors of antidepressant response in depressed patients with CVD. Whether successful treatment of depression is associated with a reduction in cardiac morbidity and mortality remains unknown. CI - © 2013 Wiley Periodicals, Inc. FAU - Mavrides, Nicole AU - Mavrides N AD - Department of Psychiatry and Behavioral Sciences, Center on Aging, Miller School of Medicine, University of Miami, Miami, Florida. FAU - Nemeroff, Charles AU - Nemeroff C LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. PT - Review DEP - 20130104 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 RN - 0 (Antidepressive Agents) SB - IM MH - Antidepressive Agents/*therapeutic use MH - Cardiovascular Diseases/*psychology MH - Depressive Disorder, Major/psychology/*therapy MH - Female MH - Humans MH - Male MH - Psychotherapy/*methods MH - Treatment Outcome EDAT- 2013/01/08 06:00 MHDA- 2013/10/18 06:00 CRDT- 2013/01/08 06:00 PHST- 2012/09/18 00:00 [received] PHST- 2012/12/06 00:00 [revised] PHST- 2012/12/08 00:00 [accepted] PHST- 2013/01/08 06:00 [entrez] PHST- 2013/01/08 06:00 [pubmed] PHST- 2013/10/18 06:00 [medline] AID - 10.1002/da.22051 [doi] PST - ppublish SO - Depress Anxiety. 2013 Apr;30(4):328-41. doi: 10.1002/da.22051. Epub 2013 Jan 4. PMID- 12024958 OWN - NLM STAT- MEDLINE DCOM- 20021202 LR - 20051116 IS - 0019-5499 (Print) IS - 0019-5499 (Linking) VI - 46 IP - 1 DP - 2002 Jan TI - Sleep and performance--recent trends. PG - 6-24 AB - Sleep and sleep deprivation are intimately related to performance. Sleep management of people working in different sectors of the society like multi shift workers, nurses, doctors, students in professional schools and the armed forces has a great bearing on performance, health and safety of the subject population. The detrimental effects of sleep deprivation on psychological performance are indicated as increased lapsing, cognitive slowing, memory impairment, decrease in vigilance and sustained attention and shift in optimum response capability. Its effects on physical performance are manifested as decline in ability to perform maximal exercise, self-selected walking pace and increase in perceived exertion. Sleep deprivation appears to have no effect in respect of muscle contractile properties and maximum anaerobic power. At high altitude (HA), there is a reduction in NREM sleep with frequent awakening due to hypoxia as a physiological adaptive measure to prevent accentuation of hypoxemia due to sleep-hypoventilation. Total sleep deprivation for 48 hours at high altitude can affect the acclimatization status, thermoregulation efficiency and cognitive functions. The concept of 'sleepiness' has also been studied, as it is an emerging concept for better understanding of the effects of sleep deprivation and its effects on performance. A special mention of sustained operations in the armed forces has been made keeping in mind its uniqueness in challenging the normal sleep-work schedule and its deployment in extreme environment and operational condition. This article reviews in detail the functions of sleep, its requirement and the effects of sleep deprivation on human performance. FAU - Himashree, Gidugu AU - Himashree G AD - Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi-110 054. FAU - Banerjee, P K AU - Banerjee PK FAU - Selvamurthy, W AU - Selvamurthy W LA - eng PT - Journal Article PT - Review PL - India TA - Indian J Physiol Pharmacol JT - Indian journal of physiology and pharmacology JID - 0374707 SB - IM MH - Circadian Rhythm/physiology MH - Humans MH - Psychomotor Performance/*physiology MH - Sleep/*physiology MH - Sleep Deprivation/physiopathology/psychology RF - 177 EDAT- 2002/05/25 10:00 MHDA- 2002/12/03 04:00 CRDT- 2002/05/25 10:00 PHST- 2002/05/25 10:00 [pubmed] PHST- 2002/12/03 04:00 [medline] PHST- 2002/05/25 10:00 [entrez] PST - ppublish SO - Indian J Physiol Pharmacol. 2002 Jan;46(1):6-24. PMID- 38853462 OWN - NLM STAT- MEDLINE DCOM- 20240711 LR - 20240715 IS - 1097-0274 (Electronic) IS - 0271-3586 (Linking) VI - 67 IP - 8 DP - 2024 Aug TI - Work-related suicide: Evolving understandings of etiology & intervention. PG - 679-695 LID - 10.1002/ajim.23624 [doi] AB - Previously published analyses of suicide case investigations suggest that work or working conditions contribute to 10%-13% of suicide deaths. Yet, the way in which work may increase suicide risk is an underdeveloped area of epidemiologic research. In this Commentary, we propose a definition of work-related suicide from an occupational health and safety perspective, and review the case investigation-based and epidemiologic evidence on work-related causes of suicide. We identified six broad categories of potential work-related causes of suicide, which are: (1) workplace chemical, physical, and psychosocial exposures; (2) exposure to trauma on the job; (3) access to means of suicide through work; (4) exposure to high-stigma work environments; (5) exposure to normative environments promoting extreme orientation to work; and (6) adverse experiences arising from work-related injury or illness. We summarise current evidence in a schema of potential work-related causes that can also be applied in workplace risk assessment and suicide case investigations. There are numerous implications of these findings for policy and practice. Various principle- and evidence-based workplace intervention strategies for suicide prevention exist, some of which have been shown to improve suicide-prevention literacy, reduce stigma, enhance helping behaviours, and in some instances maybe even reduce suicide rates. Prevailing practice in workplace suicide prevention, however, overly emphasises individual- and illness-directed interventions, with little attention directed to addressing the working conditions that may increase suicide risk. We conclude that a stronger emphasis on improving working conditions will be required for workplace suicide prevention to reach its full preventive potential. CI - © 2024 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC. FAU - LaMontagne, Anthony D AU - LaMontagne AD AUID- ORCID: 0000-0002-5811-5906 AD - Institute for Health Transformation & School of Health & Social Development, Deakin University, Geelong, Victoria, Australia. FAU - Åberg, Maria AU - Åberg M AD - School of Public Health and Community Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. FAU - Blomqvist, Sandra AU - Blomqvist S AD - Department of Psychology, Stress Research Institute, Stockholm University, Stockholm, Sweden. FAU - Glozier, Nick AU - Glozier N AD - Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Greiner, Birgit A AU - Greiner BA AD - School of Public Health, University College Cork, Cork, Ireland. FAU - Gullestrup, Jorgen AU - Gullestrup J AD - Institute for Health Transformation & School of Health & Social Development, Deakin University, Geelong, Victoria, Australia. FAU - Harvey, Samuel B AU - Harvey SB AD - Black Dog Institute, University of New South Wales, Randwick, New South Wales, Australia. FAU - Kyron, Michael J AU - Kyron MJ AD - Suicide Prevention and Resilience Research Center (SPARRC), School of Psychological Science, Perth, Western Australia, Australia. FAU - Madsen, Ida E H AU - Madsen IEH AD - National Research Centre for the Working Environment, Copenhagen, Denmark. AD - National Institute of Public Health, Copenhagen, Denmark. FAU - Hanson, Linda Magnusson AU - Hanson LM AD - Department of Psychology, Stress Research Institute, Stockholm University, Stockholm, Sweden. FAU - Maheen, Humaira AU - Maheen H AD - Centre for Health Policy, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia. FAU - Mustard, Cameron AU - Mustard C AD - Instutute for Work & Health, Toronto, Ontario, Canada. FAU - Niedhammer, Isabelle AU - Niedhammer I AD - Institut National de la Santé et de la Recherche Médicale (INSERM), Univ Angers, Angers, France. FAU - Rugulies, Reiner AU - Rugulies R AD - National Research Centre for the Working Environment, Copenhagen, Denmark. AD - Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark. FAU - Smith, Peter M AU - Smith PM AUID- ORCID: 0000-0001-8286-4563 AD - Instutute for Work & Health, Toronto, Ontario, Canada. FAU - Taouk, Yamna AU - Taouk Y AD - Centre for Health Policy, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia. FAU - Waters, Sarah AU - Waters S AD - School of Languages, Cultures and Societies, University of Leeds, Leeds, UK. FAU - Witt, Katrina AU - Witt K AD - Orygen Centre for Youth Mental Health, Parkville, Victoria, Australia. FAU - King, Tania L AU - King TL AD - Centre for Health Policy, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia. LA - eng GR - National Health and Medical Research Council/ PT - Journal Article PT - Review DEP - 20240609 PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 SB - IM MH - Humans MH - *Workplace/psychology MH - *Suicide/statistics & numerical data/psychology MH - Occupational Health MH - Suicide Prevention MH - Risk Factors MH - Occupational Exposure/adverse effects MH - Social Stigma MH - Risk Assessment OTO - NOTNLM OT - exposures OT - hazards OT - occupational OT - self‐harm OT - suicidal behaviours OT - suicide OT - work OT - work environment OT - working conditions OT - work‐related EDAT- 2024/06/10 06:42 MHDA- 2024/07/11 12:43 CRDT- 2024/06/10 02:23 PHST- 2024/05/24 00:00 [revised] PHST- 2024/01/25 00:00 [received] PHST- 2024/05/28 00:00 [accepted] PHST- 2024/07/11 12:43 [medline] PHST- 2024/06/10 06:42 [pubmed] PHST- 2024/06/10 02:23 [entrez] AID - 10.1002/ajim.23624 [doi] PST - ppublish SO - Am J Ind Med. 2024 Aug;67(8):679-695. doi: 10.1002/ajim.23624. Epub 2024 Jun 9. PMID- 28079675 OWN - NLM STAT- MEDLINE DCOM- 20170817 LR - 20181202 IS - 1473-6578 (Electronic) IS - 0951-7367 (Linking) VI - 30 IP - 2 DP - 2017 Mar TI - Recent advances in the management of neuropsychiatric symptoms in dementia. PG - 151-158 LID - 10.1097/YCO.0000000000000309 [doi] AB - PURPOSE OF REVIEW: The present article addresses intriguing questions related to the clinical intervention in distinct neuropsychiatric syndromes of patients with dementia. RECENT FINDINGS: We reviewed 154 articles published between 2015 and 2016 targeting psychopharmacological and nonpharmacological interventions, and safety-tolerability concerns. We selected 115 articles addressing the purpose of this study. Of these, 33 were chosen because they were dedicated to subtopics: agitation (42), depression (33), apathy (18), sleep disorders/anxiety (8), and psychosis (4). Clinical studies using both pharmacological (70) and nonpharmacological (37) interventions were considered; others were included for theoretical support. Regarding the methodological design, we found double-blind RCTs (17), single-blinded RCTs (4), open-label studies (18), case reports (5), cross-sectional or cohort studies (25), epidemiological papers (2), and expert reviews (44). This observation raises concerns about the overall methodological adequacy of a substantial proportion of studies in this field, which limits the potential of generalization of the findings. Finally, 18 studies were designed to determine safety-tolerability issues of psychotropic medications (6 were discussed). SUMMARY: Effective and well tolerated treatment of neuropsychiatric syndromes in dementia remains a critically unsolved challenge. We understand that this is an extremely important area of research, and critically required to guide clinical decisions in geriatric neuropsychiatry. FAU - Forlenza, Orestes V AU - Forlenza OV AD - aLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo bUNESP - Universidade Estadual Paulista, Biosciences Institute, Campus of Rio Claro, SP, Brazil. FAU - Loureiro, Júlia Cunha AU - Loureiro JC FAU - Pais, Marcos Vasconcelos AU - Pais MV FAU - Stella, Florindo AU - Stella F LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Psychiatry JT - Current opinion in psychiatry JID - 8809880 RN - 0 (Psychotropic Drugs) SB - IM MH - Aged MH - Alzheimer Disease/diagnosis/psychology/therapy MH - Anxiety Disorders/diagnosis/psychology/therapy MH - Apathy/drug effects MH - Combined Modality Therapy MH - Cross-Sectional Studies MH - Dementia/diagnosis/psychology/*therapy MH - Depressive Disorder/diagnosis/psychology/therapy MH - Double-Blind Method MH - Humans MH - Neurocognitive Disorders/diagnosis/psychology/*therapy MH - Prodromal Symptoms MH - Psychomotor Agitation/diagnosis/psychology/therapy MH - Psychopathology MH - Psychotic Disorders/diagnosis/psychology/therapy MH - Psychotropic Drugs/therapeutic use EDAT- 2017/01/13 06:00 MHDA- 2017/08/18 06:00 CRDT- 2017/01/13 06:00 PHST- 2017/01/13 06:00 [pubmed] PHST- 2017/08/18 06:00 [medline] PHST- 2017/01/13 06:00 [entrez] AID - 10.1097/YCO.0000000000000309 [doi] PST - ppublish SO - Curr Opin Psychiatry. 2017 Mar;30(2):151-158. doi: 10.1097/YCO.0000000000000309. PMID- 22392828 OWN - NLM STAT- MEDLINE DCOM- 20121022 LR - 20120306 IS - 1875-9114 (Electronic) IS - 0277-0008 (Linking) VI - 32 IP - 1 DP - 2012 Jan TI - Medical management of adult transsexual persons. PG - 54-66 LID - 10.1002/PHAR.1006 [doi] AB - Gender identity disorder (GID), or transsexualism, is an increasingly recognized medical condition with an expanding body of medical literature to support the use of established therapeutic guidelines. Transsexualism can be effectively managed through exogenous cross-sex hormone administration used to induce development of desired sex characteristics, as well as use of other agents, such as aldosterone antagonists, aimed at decreasing physical characteristics of the undesired sex. Many complications can arise with the use of the available therapies, and these must be considered before determining the appropriate course of action. This review describes methods, including both pharmacotherapy and surgical interventions, for effective medical management of both male and female adults with GID. In addition, specific goals of therapy as well as safety aspects with long-term use of pharmacotherapeutic agents are discussed. This review also discusses some special considerations for treating patients with significant, yet common, comorbid diseases such as human immunodeficiency virus infection, acquired immunodeficiency syndrome, and viral hepatitis, as these conditions may complicate the clinical course and preclude some patients from using certain therapies. Pharmacist involvement in the management of transsexualism can be extremely beneficial to patients and other health care providers. Pharmacists can help determine the appropriate therapy, optimize dosages, monitor for adverse effects, and educate patients on what to expect during their therapy. Pharmacists should become knowledgeable about guidelines and current literature on transsexualism, understand the monitoring parameters for safe and effective therapy, and establish themselves as partners in the collaborative management of this disorder. CI - © 2012, Pharmacotherapy Publications, Inc. FAU - Knezevich, Emily L AU - Knezevich EL AD - Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE 68178, USA. eknezevich@creighton.edu FAU - Viereck, Laura K AU - Viereck LK FAU - Drincic, Andjela T AU - Drincic AT LA - eng PT - Journal Article PT - Review PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 0 (Gonadal Steroid Hormones) SB - IM MH - Adult MH - Disease Management MH - Female MH - *Gender Identity MH - Gonadal Steroid Hormones/therapeutic use MH - Hormone Replacement Therapy/methods MH - Humans MH - Male MH - Pharmacists/trends MH - Transsexualism/*diagnosis/psychology/*therapy EDAT- 2012/03/07 06:00 MHDA- 2012/10/23 06:00 CRDT- 2012/03/07 06:00 PHST- 2012/03/07 06:00 [entrez] PHST- 2012/03/07 06:00 [pubmed] PHST- 2012/10/23 06:00 [medline] AID - 10.1002/PHAR.1006 [doi] PST - ppublish SO - Pharmacotherapy. 2012 Jan;32(1):54-66. doi: 10.1002/PHAR.1006. PMID- 33560523 OWN - NLM STAT- MEDLINE DCOM- 20210316 LR - 20240222 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2 IP - 2 DP - 2021 Feb 9 TI - Antidepressants for functional abdominal pain disorders in children and adolescents. PG - CD008013 LID - 10.1002/14651858.CD008013.pub3 [doi] LID - CD008013 AB - BACKGROUND: Functional Abdominal Pain Disorders (FAPDs) present a considerable burden to paediatric patients, impacting quality of life, school attendance and causing higher rates of anxiety and depression disorders. There are no international guidelines for the management of this condition. A previous Cochrane Review in 2011 found no evidence to support the use of antidepressants in this context. OBJECTIVES: To evaluate the current evidence for the efficacy and safety of antidepressants for FAPDs in children and adolescents. SEARCH METHODS: In this updated review, we searched the Cochrane Library, PubMed, MEDLINE, Embase, PsycINFO and two clinical trial registers from inception until 03 February 2020. We also updated our search of databases of ongoing research, reference lists and 'grey literature' from inception to 03 February 2020. SELECTION CRITERIA: We included randomised controlled trials (RCTs) comparing antidepressants to placebo, to no treatment or to any other intervention, in children aged 4 to 18 years with a FAPD diagnosis as per the Rome or any other defined criteria (as defined by the authors). The primary outcomes of interest included treatment success (as defined by the authors), pain severity, pain frequency and withdrawal due to adverse events. DATA COLLECTION AND ANALYSIS: Two review authors checked all citations independently, resolving disagreement with a third-party arbiter. We reviewed all potential studies in full text, and once again made independent decisions, with disagreements resolved by consensus. We conducted data extraction and 'Risk of bias' assessments independently, following Cochrane methods. Where homogeneous data were available, we performed meta-analysis using a random-effects model. We conducted GRADE analysis. MAIN RESULTS: We found one new study in this updated search, making a total of three trials (223 participants) eligible for inclusion: two using amitriptyline (AMI) and one using citalopram. For the primary outcome of treatment success, two studies used reports of success on a symptom-based Likert scale, with either a two-point reduction or the two lowest levels defined as success. The third study defined success as a 15% improvement in quality of life (QOL) ratings scales. Therefore, meta-analysis did not include this final study due to the heterogeneity of the outcome measure. There is low-certainty evidence that there may be no difference when antidepressants are compared with placebo (risk ratio (RR) 1.17, 95% confidence interval (CI) 0.87 to 1.56; 2 studies, 205 participants; I(2) = 0%). We downgraded the evidence for significant imprecision due to extremely sparse data (see Summary of findings table 1). The third study reported that participants receiving antidepressants were significantly more likely than those receiving placebo to experience at least a 15% improvement in overall QOL score at 10 and 13 weeks (P = 0.007 and P = 0.002, respectively (absolute figures were not given)). The analysis found no difference in withdrawals due to adverse events between antidepressants and placebo: RR 3.17 (95% CI 0.65 to 15.33), with very low certainty due to high risk of bias in studies and imprecision due to low event and participant numbers. Sensitivity analysis using a fixed-effect model and analysing just for AMI found no change in this result. Due to heterogeneous and limited reporting, no further meta-analysis was possible. AUTHORS' CONCLUSIONS: There may be no difference between antidepressants and placebo for treatment success of FAPDs in childhood. There may be no difference in withdrawals due to adverse events, but this is also of low certainty. There is currently no evidence to support clinical decision making regarding the use of these medications. Further studies must consider sample size, homogenous and relevant outcome measures and longer follow up. CI - Copyright © 2021 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - de Bruijn, Clara Marieke Andrea AU - de Bruijn CMA AD - Amsterdam, Netherlands. FAU - Rexwinkel, Robyn AU - Rexwinkel R AD - Amsterdam, Netherlands. FAU - Gordon, Morris AU - Gordon M AD - School of Medicine, University of Central Lancashire, Preston, UK. FAU - Benninga, Marc AU - Benninga M AD - Department of Paediatric Gastroenterology, Emma Children's Hospital/AMC, Amsterdam, Netherlands. FAU - Tabbers, Merit M AU - Tabbers MM AD - Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20210209 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 0 (Antidepressive Agents, Second-Generation) RN - 0 (Antidepressive Agents, Tricyclic) RN - 0 (Placebos) RN - 0DHU5B8D6V (Citalopram) RN - 1806D8D52K (Amitriptyline) SB - IM UOF - Cochrane Database Syst Rev. 2011 Jul 06;(7):CD008013. doi: 10.1002/14651858.CD008013.pub2. PMID: 21735420 MH - Abdominal Pain/*drug therapy/psychology MH - Adolescent MH - Amitriptyline/adverse effects/*therapeutic use MH - Antidepressive Agents, Second-Generation/adverse effects/*therapeutic use MH - Antidepressive Agents, Tricyclic/adverse effects/*therapeutic use MH - Child MH - Citalopram/adverse effects/*therapeutic use MH - Gastrointestinal Diseases/*drug therapy/psychology MH - Humans MH - Irritable Bowel Syndrome/drug therapy MH - Placebos/therapeutic use MH - Quality of Life MH - Randomized Controlled Trials as Topic PMC - PMC8094232 COIS- MB: Consultant for Shire, Norgine, Coloplast, Danone, Takeda, Allergan, Shire, FrieslandCampina, United Pharamceuticals. MT: None known MG: Since August 2016, I have received travel fees to attend international scientific and training meetings from Pharma companies. These grants included no honoraria, inducement, advisory role or any other relationship and were restricted to the travel and meeting related costs of attending such meetings. These include: DDW May 2017, World Congress of Gastroenterology October 2017, DDW May 2018, Advances in IBD December 2018, DDW May 2019. None of these companies have had any involvement in any works completed by me and I have never had any payments for any other activities for them, as confirmed below. From this date onwards, I have made a personal undertaking to take no further funds from any pharmaceutical or formula company in any form for travel or other related activities. This is to lift the limitations such funding has on my ability to act as a first and corresponding author on reviews, in line with the Cochrane policies on such matters and is reported in line with these policies. These current declarations will expire over the next three years and this statement updated regularly to reflect this.
RR: None known. CB: None known. EDAT- 2021/02/10 06:00 MHDA- 2021/03/17 06:00 PMCR- 2022/02/09 CRDT- 2021/02/09 12:11 PHST- 2021/02/09 12:11 [entrez] PHST- 2021/02/10 06:00 [pubmed] PHST- 2021/03/17 06:00 [medline] PHST- 2022/02/09 00:00 [pmc-release] AID - CD008013.pub3 [pii] AID - 10.1002/14651858.CD008013.pub3 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2021 Feb 9;2(2):CD008013. doi: 10.1002/14651858.CD008013.pub3. PMID- 33042652 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201013 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 12 IP - 10 DP - 2020 Oct 4 TI - Unveiling the Mystery of Peripartum Cardiomyopathy: A Traditional Review. PG - e10790 LID - 10.7759/cureus.10790 [doi] LID - e10790 AB - Peripartum cardiomyopathy (PPCM) can be classified as a variant of dilated cardiomyopathy identified usually within the first five months of delivery or during the last month of pregnancy. This condition presents as systolic heart failure. PPCM affects thousands of women in the United States each year. Even though it was first noticed in the 1800s, its etiology remains unknown. This study aims to review the pathophysiology and management of PPCM and explore the possible outcomes of peripartum cardiomyopathy. PPCM can lead to maternal death if diagnosis or treatment is delayed. Diagnosing PPCM has been challenging because it can be misdiagnosed or perceived as a sign of pregnancy since most of the symptoms of PPCM strongly match those within the typical pregnancy continuum and postpartum cycle. Patients' implications are fatal and carry a high mortality rate when PPCM is misdiagnosed or treatment is delayed. To accurately identify PPCM, using echocardiography, the left ventricular end-diastolic size and the ejection fraction should be measured to determine the severity of PPCM. Managing peripartum cardiomyopathy involves using traditional treatments for heart failure. Therapeutic recommendations are made depending on the patient's status (pregnancy, breastfeeding, postpartum) while considering the drug-safety profiles before administration. Some other treatments have also been used to control PPCM depending on how severe it has become; for example, antiarrhythmics have been used to treat cardiac arrhythmias when they ensue. In extreme cases, mechanical assistance and transplantation could be required. Based on the proposed pathophysiology involving the 16kDA anti-angiogenic sub-fragment, bromocriptine may be used even though it still needs more assessment due to limited evidence. Using PubMed as a major search resource, a thorough analysis of publications was carried out after incorporating this review's inclusion and exclusion criteria. A total of 455,141 publications were found using keywords and keyword combinations. With a careful selection of articles, 31 publications provided relevant information on our primary endpoint. All articles in this examination were chosen without limitation to the type of study, including clinical trials, review articles, meta-analyses, and so on. Our review suggests that, based on factors such as early detection and management, disease severity, ethnicity, and quality of patient care, patients with PPCM presented different outcomes and prognosis. However, despite PPCM's high mortality rate and its risk of recurrence, most patients tend to recover within six months of disease onset. CI - Copyright © 2020, Chinweuba et al. FAU - Chinweuba, Goodness C AU - Chinweuba GC AD - Obstetrics and Gynecology, Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA. FAU - Rutkofsky, Ian H AU - Rutkofsky IH AD - Psychiatry, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA. LA - eng PT - Journal Article PT - Review DEP - 20201004 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC7535944 OTO - NOTNLM OT - cardiomyopathy OT - diagnosis of peripartum cardiomyopathy OT - dilated cardiomyopathy OT - dyspnea OT - heart failure OT - outcomes of peripartum cardiomyopathy OT - peripartum OT - peripartum cardiomyopathy OT - pregnancy COIS- The authors have declared that no competing interests exist. EDAT- 2020/10/13 06:00 MHDA- 2020/10/13 06:01 PMCR- 2020/10/04 CRDT- 2020/10/12 05:31 PHST- 2020/10/12 05:31 [entrez] PHST- 2020/10/13 06:00 [pubmed] PHST- 2020/10/13 06:01 [medline] PHST- 2020/10/04 00:00 [pmc-release] AID - 10.7759/cureus.10790 [doi] PST - epublish SO - Cureus. 2020 Oct 4;12(10):e10790. doi: 10.7759/cureus.10790. PMID- 29953902 OWN - NLM STAT- MEDLINE DCOM- 20190923 LR - 20190923 IS - 1879-016X (Electronic) IS - 0163-7258 (Linking) VI - 192 DP - 2018 Dec TI - Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. PG - 20-41 LID - S0163-7258(18)30114-1 [pii] LID - 10.1016/j.pharmthera.2018.06.012 [doi] AB - The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug clozapine has been a revolutionary pharmacological step for treating psychotic patients as these allow a significant recovery not only in terms of hospitalization and reduction in symptoms severity, but also in terms of safety, socialization and better rehabilitation in the society. Regarding the mechanism of action, AAPs are weak D(2) receptor antagonists and they act beyond D(2) antagonism, involving other receptor targets which regulate dopamine and other neurotransmitters. Consequently, AAPs present a significant reduction of deleterious side effects like parkinsonism, hyperprolactinemia, apathy and anhedonia, which are all linked to the strong blockade of D(2) receptors. This review revisits previous and current findings within the class of AAPs and highlights the differences in terms of receptor properties and clinical activities among them. Furthermore, we propose a continuum spectrum of "atypia" that begins with risperidone (the least atypical) to clozapine (the most atypical), while all the other AAPs fall within the extremes of this spectrum. Clozapine is still considered the gold standard in refractory schizophrenia and in psychoses present in Parkinson's disease, though it has been associated with adverse effects like agranulocytosis (0.7%) and weight gain, pushing the scientific community to find new drugs as effective as clozapine, but devoid of its side effects. To achieve this, it is therefore imperative to characterize and compare in depth the very complex molecular profile of AAPs. We also introduce relatively new concepts like biased agonism, receptor dimerization and neurogenesis to identify better the old and new hallmarks of "atypia". Finally, a detailed confrontation of clinical differences among the AAPs is presented, especially in relation to their molecular targets, and new means like therapeutic drug monitoring are also proposed to improve the effectiveness of AAPs in clinical practice. CI - Copyright © 2018 Elsevier Inc. All rights reserved. FAU - Aringhieri, Stefano AU - Aringhieri S AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Carli, Marco AU - Carli M AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Kolachalam, Shivakumar AU - Kolachalam S AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Verdesca, Valeria AU - Verdesca V AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Cini, Enrico AU - Cini E AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Rossi, Mario AU - Rossi M AD - Institute of Molecular Cell and Systems Biology, University of Glasgow, UK. FAU - McCormick, Peter J AU - McCormick PJ AD - William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK. FAU - Corsini, Giovanni U AU - Corsini GU AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. FAU - Maggio, Roberto AU - Maggio R AD - Biotechnological and Applied Clinical Sciences Department, University of L'Aquila, Italy. FAU - Scarselli, Marco AU - Scarselli M AD - Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy. Electronic address: marco.scarselli@med.unipi.it. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20180625 PL - England TA - Pharmacol Ther JT - Pharmacology & therapeutics JID - 7905840 RN - 0 (Antipsychotic Agents) RN - 0 (Receptors, Cholinergic) RN - 0 (Receptors, Dopamine) RN - 0 (Receptors, Glutamate) RN - 0 (Receptors, Histamine) RN - 0 (Receptors, Serotonin) RN - J60AR2IKIC (Clozapine) SB - IM MH - Animals MH - Antipsychotic Agents/adverse effects/pharmacokinetics/*pharmacology/therapeutic use MH - Clozapine/adverse effects/*pharmacology/therapeutic use MH - *Drug Design MH - Humans MH - Molecular Targeted Therapy MH - Precision Medicine MH - Psychology, Clinical MH - Receptors, Cholinergic/metabolism MH - Receptors, Dopamine/*metabolism MH - Receptors, Glutamate/metabolism MH - Receptors, Histamine/metabolism MH - Receptors, Serotonin/*metabolism MH - Schizophrenia/*drug therapy/metabolism OTO - NOTNLM OT - Atypical antipsychotics OT - Biased agonism OT - Clozapine OT - Dimerization OT - Monoamine receptors OT - Therapeutic drug monitoring EDAT- 2018/06/29 06:00 MHDA- 2019/09/24 06:00 CRDT- 2018/06/29 06:00 PHST- 2018/06/29 06:00 [pubmed] PHST- 2019/09/24 06:00 [medline] PHST- 2018/06/29 06:00 [entrez] AID - S0163-7258(18)30114-1 [pii] AID - 10.1016/j.pharmthera.2018.06.012 [doi] PST - ppublish SO - Pharmacol Ther. 2018 Dec;192:20-41. doi: 10.1016/j.pharmthera.2018.06.012. Epub 2018 Jun 25. PMID- 33029503 OWN - NLM STAT- MEDLINE DCOM- 20201016 LR - 20240802 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2020 DP - 2020 TI - Resistance Training Safety during and after the SARS-Cov-2 Outbreak: Practical Recommendations. PG - 3292916 LID - 10.1155/2020/3292916 [doi] LID - 3292916 AB - In December of 2019, there was an outbreak of a severe acute respiratory syndrome caused by the coronavirus 2 (SARS-CoV-2 or COVID-19) in China. The virus rapidly spread into the whole world causing an unprecedented pandemic and forcing governments to impose a global quarantine, entering an extreme unknown situation. The organizational consequences of quarantine/isolation are absence of organized training and competition, lack of communication among athletes and coaches, inability to move freely, lack of adequate sunlight exposure, and inappropriate training conditions. The reduction of mobility imposed to contain the advance of the SARS-Cov-2 pandemic can negatively affect the physical condition and health of individuals leading to muscle atrophy, progressive loss of muscle strength, and reductions in neuromuscular and mechanical capacities. Resistance training (RT) might be an effective tool to counteract these adverse consequences. RT is considered an essential part of an exercise program due to its numerous health and athletic benefits. However, in the face of the SARS-Cov-2 outbreak, many people might be concerned with safety issues regarding its practice, especially in indoor exercise facilities, such as gyms and fitness centers. These concerns might be associated with RT impact in the immune system, respiratory changes, and contamination due to equipment sharing and agglomeration. In this current opinion article, we provide insights to address these issues to facilitate the return of RT practices under the new logistical and health challenges. We understand that RT can be adapted to allow its performance with measures adopted to control coronavirus outbreak such that the benefits would largely overcome the potential risks. The article provides some practical information to help on its implementation. CI - Copyright © 2020 Paulo Gentil et al. FAU - Gentil, Paulo AU - Gentil P AUID- ORCID: 0000-0003-2459-4977 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. AD - Liga de Hipertensão Arterial, Universidade Federal de Goiás, Goiânia, Brazil. FAU - de Lira, Claudio Andre Barbosa AU - de Lira CAB AUID- ORCID: 0000-0001-5749-6877 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. FAU - Souza, Daniel AU - Souza D AUID- ORCID: 0000-0002-2721-1778 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. FAU - Jimenez, Alfonso AU - Jimenez A AUID- ORCID: 0000-0001-5295-9668 AD - GO fit LAB, Ingesport, Madrid, Spain. AD - Advanced Wellbeing Research Centre, Sheffield Hallam University, Sheffield, UK. AD - Centre for Sport Studies, King Juan Carlos University, Madrid, Spain. FAU - Mayo, Xian AU - Mayo X AUID- ORCID: 0000-0002-4143-701X AD - GO fit LAB, Ingesport, Madrid, Spain. AD - Centre for Sport Studies, King Juan Carlos University, Madrid, Spain. FAU - de Fátima Pinho Lins Gryschek, Anna Luiza AU - de Fátima Pinho Lins Gryschek AL AUID- ORCID: 0000-0001-5012-5977 AD - Departamento de Enfermagem em Saúde Coletiva da Escola de Enfermagem da Universidade de São Paulo, São Paulo, Brazil. FAU - Pereira, Erica Gomes AU - Pereira EG AD - Departamento de Enfermagem em Saúde Coletiva da Escola de Enfermagem da Universidade de São Paulo, São Paulo, Brazil. FAU - Alcaraz, Pedro AU - Alcaraz P AUID- ORCID: 0000-0002-9792-6656 AD - Research Center for High Performance Sport, UCAM, Murcia, Spain. AD - Faculty of Sport Sciences, UCAM, Murcia, Spain. FAU - Bianco, Antonino AU - Bianco A AUID- ORCID: 0000-0001-8334-6581 AD - Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy. FAU - Paoli, Antonio AU - Paoli A AUID- ORCID: 0000-0003-0474-4229 AD - Department of Biomedical Sciences, Physiological Laboratory, University of Padova, Padova, Italy. FAU - Papeschi, Julio AU - Papeschi J AD - Instituto Valorize, Vitória, Brazil. FAU - Carnevali Junior, Luiz Carlos AU - Carnevali Junior LC AD - Centro Universitário UniFMU, São Paulo, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20200923 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Betacoronavirus MH - COVID-19 MH - China/epidemiology MH - Coronavirus Infections/*epidemiology/physiopathology/transmission MH - Disinfection/methods MH - Humans MH - Immune System/physiopathology MH - *Pandemics/prevention & control MH - Pneumonia, Viral/*epidemiology/physiopathology/transmission MH - Resistance Training/*adverse effects/instrumentation/*methods MH - Respiratory System/physiopathology MH - Risk Factors MH - SARS-CoV-2 MH - Safety PMC - PMC7532374 COIS- LCCJ is a scientific director for Instituto Smartfit. PG has a share in Academia Malhart The authors report no conflict of interest. EDAT- 2020/10/09 06:00 MHDA- 2020/10/21 06:00 PMCR- 2020/09/23 CRDT- 2020/10/08 05:34 PHST- 2020/05/28 00:00 [received] PHST- 2020/08/05 00:00 [revised] PHST- 2020/09/11 00:00 [accepted] PHST- 2020/10/08 05:34 [entrez] PHST- 2020/10/09 06:00 [pubmed] PHST- 2020/10/21 06:00 [medline] PHST- 2020/09/23 00:00 [pmc-release] AID - 10.1155/2020/3292916 [doi] PST - epublish SO - Biomed Res Int. 2020 Sep 23;2020:3292916. doi: 10.1155/2020/3292916. eCollection 2020. PMID- 27793420 OWN - NLM STAT- MEDLINE DCOM- 20180110 LR - 20220330 IS - 1558-075X (Electronic) IS - 0146-0005 (Linking) VI - 40 IP - 8 DP - 2016 Dec TI - Measuring and communicating meaningful outcomes in neonatology: A family perspective. PG - 571-577 LID - S0146-0005(16)30081-7 [pii] LID - 10.1053/j.semperi.2016.09.009 [doi] AB - Medium- and long-term outcomes have been collected and described among survivors of neonatal intensive care units for decades, for a number of purposes: (1) quality control within units, (2) comparisons of outcomes between NICUs, (3) clinical trials (whether an intervention improves outcomes), (4) end-of-life decision-making, (5) to better understand the effects of neonatal conditions and/or interventions on organs and/or long-term health, and finally (6) to better prepare parents for the future. However, the outcomes evaluated have been selected by investigators, based on feasibility, availability, cost, stability, and on what investigators consider to be important. Many of the routinely measured outcomes have major limitations: they may not correlate well with long-term difficulties, they may artificially divide continuous outcomes into dichotomous ones, and may have no clear relationship with quality of life and functioning of children and their families. Several investigations, such as routine term cerebral resonance imaging for preterm infants, have also not yet been shown to improve the outcome of children nor their families. In this article, the most common variables used in neonatology as well as some variables which are rarely measured but may be of equal importance for families are presented. The manner in which these outcomes are communicated to families will be examined, as well as recommendations to optimize communication with parents. CI - Copyright © 2016 Elsevier Inc. All rights reserved. FAU - Janvier, Annie AU - Janvier A AD - Department of Pediatrics, Université de Montréal; Division of Neonatology and centre de recherche, CHU Sainte-Justine, Montréal, Canada; Bureau de l'Éthique Clinique, Université de Montréal, Canada; Unité d'éthique clinique, unité de soins palliatifs, unité de recherche en éthique clinique et partenariat famille, Hôpital Sainte-Justine, Montréal, Canada. Electronic address: anniejanvier@hotmail.com. FAU - Farlow, Barbara AU - Farlow B AD - Parent and patient representative, patients for Patient Safety Canada, Edmonton, Alberta, Canada; The deVeber Institute for Bioethics and Social Research, North York, Ontario Canada. FAU - Baardsnes, Jason AU - Baardsnes J AD - Parent representative, Human Health Therapeutics, National Research Council, Montréal, Canada. FAU - Pearce, Rebecca AU - Pearce R AD - Parent representative, Villa Maria High School, Montreal, Quebec'. FAU - Barrington, Keith J AU - Barrington KJ AD - Department of Pediatrics, Université de Montréal; Division of Neonatology and centre de recherche, CHU Sainte-Justine, Montréal, Canada. LA - eng PT - Journal Article PT - Review DEP - 20161026 PL - United States TA - Semin Perinatol JT - Seminars in perinatology JID - 7801132 SB - IM MH - Benchmarking MH - Communication MH - Decision Making MH - Emotions MH - Evidence-Based Medicine MH - *Health Services Research MH - Humans MH - Infant, Newborn MH - Infant, Premature MH - Infant, Premature, Diseases/psychology/*therapy MH - Infant, Very Low Birth Weight MH - *Intensive Care Units, Neonatal/standards MH - *Neonatology MH - Outcome Assessment, Health Care MH - *Palliative Care/standards MH - Parents/*psychology MH - *Professional-Family Relations/ethics MH - Quality Assurance, Health Care MH - Quality of Life OTO - NOTNLM OT - Communication OT - Congenital anomalies OT - Disability OT - Empathy OT - End-of-life decisions OT - Extreme prematurity OT - Family-centered care OT - Life-sustaining interventions OT - Neonatal intensive care unit OT - Palliative care OT - Screening EDAT- 2016/10/30 06:00 MHDA- 2018/01/11 06:00 CRDT- 2016/10/30 06:00 PHST- 2016/10/30 06:00 [pubmed] PHST- 2018/01/11 06:00 [medline] PHST- 2016/10/30 06:00 [entrez] AID - S0146-0005(16)30081-7 [pii] AID - 10.1053/j.semperi.2016.09.009 [doi] PST - ppublish SO - Semin Perinatol. 2016 Dec;40(8):571-577. doi: 10.1053/j.semperi.2016.09.009. Epub 2016 Oct 26. PMID- 16027555 OWN - NLM STAT- MEDLINE DCOM- 20051206 LR - 20190911 IS - 0271-0749 (Print) IS - 0271-0749 (Linking) VI - 25 IP - 4 Suppl 1 DP - 2005 Aug TI - Treatment of depression in the medically ill. PG - S14-8 AB - Most studies on treatment methods in elderly depressive patients have included primarily patients in good physical health, excluding medical comorbidity, despite the fact that depression with medical comorbidity is the norm rather than the exception. In addition, depression is known to increase disability and mortality among the medically ill. This, therefore, becomes an extremely important issue. Although data are limited, the available evidence suggests that depression concomitant with medical illness can be treated. One or more of the selective serotonin reuptake inhibitors have demonstrated potential usefulness in depressed patients with ischemic heart disease, diabetes, dementia, and Parkinson's disease and in patients after stroke and after myocardial infarction. Large-scale trials are needed to assess not only the safety and effectiveness of agents for the treatment of depression in comorbid illness, but also the effects of depression on the course of the medical illness itself. FAU - Krishnan, K Ranga Rama AU - Krishnan KR AD - Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Rm. 4584 White Zone, Duke South, Durham, NC 27710, USA. krish001@mc.duke.edu LA - eng PT - Journal Article PT - Review PL - United States TA - J Clin Psychopharmacol JT - Journal of clinical psychopharmacology JID - 8109496 RN - 0 (Antidepressive Agents) SB - IM MH - Antidepressive Agents/therapeutic use MH - Cognitive Behavioral Therapy MH - Coronary Artery Disease/*psychology MH - Dementia/*psychology MH - Depressive Disorder/etiology/*therapy MH - Diabetes Mellitus/*psychology MH - Humans MH - Parkinson Disease/*psychology MH - Stroke/*psychology RF - 44 EDAT- 2005/07/20 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/07/20 09:00 PHST- 2005/07/20 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/07/20 09:00 [entrez] AID - 00004714-200508001-00003 [pii] AID - 10.1097/01.jcp.0000162808.92194.2a [doi] PST - ppublish SO - J Clin Psychopharmacol. 2005 Aug;25(4 Suppl 1):S14-8. doi: 10.1097/01.jcp.0000162808.92194.2a. PMID- 34390631 OWN - NLM STAT- MEDLINE DCOM- 20210901 LR - 20210901 IS - 1066-2936 (Print) IS - 1066-2936 (Linking) VI - 48 IP - 3 DP - 2021 Third Quarter TI - Submarine medicine: An overview of the unique challenges, medical concerns, and gaps. PG - 263-278 AB - Submariners face many challenges. For example, they "live where they work" and can be called to duty anytime. They have limited access to open space, natural settings, fresh air, fresh food, sunlight, privacy, exercise, and outside communication. They support a wider range of missions than occur aboard most other Navy vessels. At sea or on shore, submariners work long hours under conditions with little margin for error. They may traverse remote or disputed areas of the ocean far from rescue assets, and must remain vigilant for potential encounters with hostile forces, onboard fires, anomalies in the breathing atmosphere, leaks, undersea collisions, or radiation exposures. If any of these factors cause casualties, the Independent Duty Corpsman (with intermittent advice from shore-based medical personnel), must be ready to provide aid as long as necessary. The challenges of submarine service led to the growth of the unique field of submarine medicine, which has maintained an excellent record of health and safety. This review introduces the field of submarine medicine as practiced in the U.S. Navy, describing its major concerns, giving an overview of the operation of a submarine medical department, and identifying several medical gaps that researchers are working to fill. Submarine medicine already has a stellar record in terms of radiation and atmospheric safety and has made strides in fatigue management. Ongoing work will deliver improved psychological screening and support tools. This report summarizes developments in these and other areas of submarine medicine. CI - Copyright© Undersea and Hyperbaric Medical Society. FAU - Beardslee, Luke A AU - Beardslee LA AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. FAU - Casper, Erica T AU - Casper ET AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. FAU - Lawson, Ben D AU - Lawson BD AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. LA - eng PT - Journal Article PT - Review PL - United States TA - Undersea Hyperb Med JT - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc JID - 9312954 SB - IM MH - Air Pollution, Indoor/prevention & control MH - *Delivery of Health Care/methods MH - Fatigue/complications MH - Humans MH - Mental Health MH - Metabolic Syndrome/diagnosis MH - *Military Personnel/psychology MH - Occupational Diseases/complications/prevention & control/therapy MH - Occupational Exposure MH - Radiation Exposure MH - Remote Consultation MH - *Ships MH - *Submarine Medicine/education/methods MH - Transportation of Patients/methods MH - United States MH - Workplace OTO - NOTNLM OT - extreme environment OT - isolated and confined environment OT - submarine medicine OT - submariner health OT - undersea medicine COIS- The authors of this paper declare no conflicts of interest exist with this submission. EDAT- 2021/08/15 06:00 MHDA- 2021/09/02 06:00 CRDT- 2021/08/14 17:07 PHST- 2021/08/14 17:07 [entrez] PHST- 2021/08/15 06:00 [pubmed] PHST- 2021/09/02 06:00 [medline] PST - ppublish SO - Undersea Hyperb Med. 2021 Third Quarter;48(3):263-278. PMID- 33230984 OWN - NLM STAT- MEDLINE DCOM- 20210811 LR - 20210811 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 35 IP - 45 DP - 2020 Nov 23 TI - Apprehensions about Excessive Belief in Digital Therapeutics: Points of Concern Excluding Merits. PG - e373 LID - 10.3346/jkms.2020.35.e373 [doi] LID - e373 AB - Digital therapeutics (DTx), like drugs or medical devices, 1) must prove their effectiveness and safety through clinical trials; 2) are provided to patients through prescriptions from doctors; and 3) may require the approval of regulatory agencies, though this might not be mandatory. Although DTx will play an important role in the medical field in the near future, some merits of DTx have been exaggerated at this crucial juncture. In the medical field, where safety and effectiveness are important, merely reducing the development time and costs of DTx is not advantageous. The adverse effects of DTx are not yet well-known, and will be identified eventually, with the passage of time. DTx is beneficial for the collection and analysis of real-world data (RWD); however, they require new and distinct work to collect and analyze high-quality RWD. Naturally, whether this is possible must be independently ascertained through scientific methods. Depending on the type of disease, it is not recommended that DTx be prescribed, even if the patient rejects conventional treatment. Prescription of conventional pharmacotherapy is often necessary, and if the prescription of DTx is inadequate, the critical time for initial treatment may be missed. There is no basis for continuing DTx use by patients. Rather, the rate of continuity of DTx use is extremely low. While many conventional pharmacotherapies have undergone numerous verification and safety tests over a long time, barriers to the application of DTx in the medical field are lower than those for conventional pharmacotherapies. Considering these reasons, except for certain special cases, an approach to DTx is needed that complements the prescription of conventional pharmacotherapy by the medical staff. When DTx are prescribed by doctors who clearly know their advantages and disadvantages, the doctors' expertise may undergo further refinement, and the quality of medical care is expected to improve. CI - © 2020 The Korean Academy of Medical Sciences. FAU - Kim, Hun Sung AU - Kim HS AUID- ORCID: 0000-0002-7002-7300 AD - Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea. AD - Department of Endocrinology and Metabolism, College of Medicine, The Catholic University of Korea, Seoul, Korea. 01cadiz@hanmail.net. LA - eng GR - S2726209/MSS/Ministry of SMEs and Startups/Korea PT - Journal Article PT - Review DEP - 20201123 PL - Korea (South) TA - J Korean Med Sci JT - Journal of Korean medical science JID - 8703518 RN - 0 (Pharmaceutical Preparations) SB - IM MH - Cognitive Behavioral Therapy MH - Complementary Therapies/economics/*methods MH - Government Regulation MH - Health Personnel/psychology MH - Humans MH - Mobile Applications MH - Patients/*psychology MH - Pharmaceutical Preparations/chemistry MH - Treatment Outcome PMC - PMC7683239 OTO - NOTNLM OT - Devices OT - Medicine OT - Patients OT - Physicians OT - Prescriptions COIS- The author has no potential conflicts of interest to disclose. EDAT- 2020/11/25 06:00 MHDA- 2021/08/12 06:00 PMCR- 2020/11/23 CRDT- 2020/11/24 06:12 PHST- 2020/07/07 00:00 [received] PHST- 2020/09/08 00:00 [accepted] PHST- 2020/11/24 06:12 [entrez] PHST- 2020/11/25 06:00 [pubmed] PHST- 2021/08/12 06:00 [medline] PHST- 2020/11/23 00:00 [pmc-release] AID - 35.e373 [pii] AID - 10.3346/jkms.2020.35.e373 [doi] PST - epublish SO - J Korean Med Sci. 2020 Nov 23;35(45):e373. doi: 10.3346/jkms.2020.35.e373. PMID- 23745447 OWN - NLM STAT- MEDLINE DCOM- 20130625 LR - 20131121 IS - 0034-8376 (Print) IS - 0034-8376 (Linking) VI - 65 IP - 1 DP - 2013 Jan-Feb TI - [Factors relating to falls in hospitalized patients]. PG - 88-93 AB - Falls are one indicator of quality, and are classified as an adverse event, where the consequences of these can range from mild to severe and even fatal; the Joint Commission International (JCI) reports them as the sixth most frequently reported event in the database Sentinel Events. A challenge for health institutions is to maintain a risk-free environment, ensuring users to achieve the expected improvement; however each hospital is extremely complex due to the constant interaction of the person with their environment, making it necessary to have clear understanding of the variables that can influence the situation. To consider a risk-free environment must be considered preventive actions to minimize risk factors, which can be both intrinsic and extrinsic, first includes the particular characteristics of the person, and the latter refers to the hospital environment. It is important to consider that within the intrinsic factors, although they cannot be completely modified, is necessary to make an assessment and identify risks to promote preventive measures, respect to the extrinsic; is responsibility of the multidisciplinary health team to identify and eliminate the causes that contribute to the presence of falls. FAU - Olvera-Arreola, Sandra Sonalí AU - Olvera-Arreola SS AD - Instituto Nacional de Cardiología Ignacio Chávez. sandra.olvera@cardiologia.org.mx FAU - Hernández-Cantoral, Alicia AU - Hernández-Cantoral A FAU - Arroyo-Lucas, Silvino AU - Arroyo-Lucas S FAU - Nava-Galán, Ma Guadalupe AU - Nava-Galán MG FAU - Zapien-Vázquez, María de los Angeles AU - Zapien-Vázquez Mde L FAU - Pérez-López, Maria Teresa AU - Pérez-López MT FAU - Cárdenas-Sánchez, Patricia Adriana AU - Cárdenas-Sánchez PA LA - spa PT - English Abstract PT - Journal Article PT - Review TT - Factores relacionados con la presencia de caídas en pacientes hospitalizados. PL - Mexico TA - Rev Invest Clin JT - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JID - 9421552 SB - IM MH - Accidental Falls/*prevention & control/statistics & numerical data MH - Age Factors MH - Aged MH - Cardiovascular Diseases/physiopathology MH - Confusion MH - Disease Susceptibility MH - Drug-Related Side Effects and Adverse Reactions MH - Female MH - Hospital Design and Construction MH - Humans MH - *Inpatients/psychology MH - Male MH - Mobility Limitation MH - Nervous System Diseases/physiopathology MH - *Patient Safety MH - Risk Factors MH - Risk Management EDAT- 2013/06/12 06:00 MHDA- 2013/06/26 06:00 CRDT- 2013/06/11 06:00 PHST- 2013/06/11 06:00 [entrez] PHST- 2013/06/12 06:00 [pubmed] PHST- 2013/06/26 06:00 [medline] PST - ppublish SO - Rev Invest Clin. 2013 Jan-Feb;65(1):88-93. PMID- 38235444 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240119 IS - 2673-6195 (Electronic) IS - 2673-6195 (Linking) VI - 3 DP - 2022 TI - Living on the edge: How to prepare for it? PG - 1007774 LID - 10.3389/fnrgo.2022.1007774 [doi] LID - 1007774 AB - INTRODUCTION: Isolated, confined, and extreme (ICE) environments such as found at Antarctic, Arctic, and other remote research stations are considered space-analogs to study the long duration isolation aspects of operational space mission conditions. METHODS: We interviewed 24 sojourners that participated in different short/long duration missions in an Antarctic (Concordia, Halley VI, Rothera, Neumayer II) or non-Antarctic (e.g., MDRS, HI-SEAS) station or in polar treks, offering a unique insight based on first-hand information on the nature of demands by ICE-personnel at multiple levels of functioning. We conducted a qualitative thematic analysis to explore how sojourners were trained, prepared, how they experienced the ICE-impact in function of varieties in environment, provided trainings, station-culture, and type of mission. RESULTS: The ICE-environment shapes the impact of organizational, interpersonal, and individual working- and living systems, thus influencing the ICE-sojourners' functioning. Moreover, more specific training for operating in these settings would be beneficial. The identified pillars such as sensory deprivation, sleep, fatigue, group dynamics, displacement of negative emotions, gender-issues along with coping strategies such as positivity, salutogenic effects, job dedication and collectivistic thinking confirm previous literature. However, in this work, we applied a systemic perspective, assembling the multiple levels of functioning in ICE-environments. DISCUSSION: A systemic approach could serve as a guide to develop future preparatory ICE-training programs, including all the involved parties of the crew system (e.g., family, on-ground crew) with attention for the impact of organization- and station-related subcultures and the risk of unawareness about the impact of poor sleep, fatigue, and isolation on operational safety that may occur on location. CI - Copyright © 2022 Van Puyvelde, Gijbels, Van Caelenberg, Smith, Bessone, Buckle-Charlesworth and Pattyn. FAU - Van Puyvelde, Martine AU - Van Puyvelde M AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Brain, Body and Cognition (BBC), Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium. AD - Clinical and Lifespan Psychology, Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium. AD - School of Natural Sciences and Psychology, Faculty of Science, Liverpool John Moores University, Liverpool, United Kingdom. FAU - Gijbels, Daisy AU - Gijbels D AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. FAU - Van Caelenberg, Thomas AU - Van Caelenberg T AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. FAU - Smith, Nathan AU - Smith N AD - Protective Security and Resilience Centre, Coventry University, Coventry, United Kingdom. FAU - Bessone, Loredana AU - Bessone L AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. FAU - Buckle-Charlesworth, Susan AU - Buckle-Charlesworth S AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. AD - Oxford Human Performance, Oxfordshire, United Kingdom. FAU - Pattyn, Nathalie AU - Pattyn N AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Human Physiology and Human Performance Lab (MFYS-BLITS), Human Physiology Department, Vrije Universiteit Brussel, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20221214 PL - Switzerland TA - Front Neuroergon JT - Frontiers in neuroergonomics JID - 9918663089006676 PMC - PMC10790891 OTO - NOTNLM OT - Antarctica OT - ICE-environment OT - confined OT - extreme environment OT - isolated OT - isolation OT - space-analog OT - training COIS- SB-C was employed by Oxford Human Performance. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/12/14 00:00 MHDA- 2022/12/14 00:01 PMCR- 2022/12/14 CRDT- 2024/01/18 04:24 PHST- 2022/07/30 00:00 [received] PHST- 2022/11/15 00:00 [accepted] PHST- 2022/12/14 00:01 [medline] PHST- 2022/12/14 00:00 [pubmed] PHST- 2024/01/18 04:24 [entrez] PHST- 2022/12/14 00:00 [pmc-release] AID - 10.3389/fnrgo.2022.1007774 [doi] PST - epublish SO - Front Neuroergon. 2022 Dec 14;3:1007774. doi: 10.3389/fnrgo.2022.1007774. eCollection 2022. PMID- 7841817 OWN - NLM STAT- MEDLINE DCOM- 19950309 LR - 20151119 IS - 0895-0172 (Print) IS - 0895-0172 (Linking) VI - 6 IP - 4 DP - 1994 Fall TI - Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function. PG - 467-77 AB - A minority of patients with obsessive-compulsive disorder (OCD) have a chronic course and extreme disability, with symptoms refractory to pharmacological and psychological treatment. Considerable uncontrolled evidence suggests such cases may respond to neurosurgical intervention. The authors update current stereotactic procedures and their efficacy, safety, and side effect profiles. The design of an ongoing placebo-controlled trial of Gamma Knife capsulotomy for refractory OCD is outlined. Drug treatment of OCD may be assumed to affect a proposed functional imbalance between the frontal lobes and other parts of the brain. As for neurosurgical treatments, both the effects and side effects may be viewed as expressions of their influence on this functional imbalance. FAU - Mindus, P AU - Mindus P AD - Department of Psychiatry and Psychology, Karolinska Institute, Stockholm, Sweden. FAU - Rasmussen, S A AU - Rasmussen SA FAU - Lindquist, C AU - Lindquist C LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - J Neuropsychiatry Clin Neurosci JT - The Journal of neuropsychiatry and clinical neurosciences JID - 8911344 SB - IM MH - Brain Mapping MH - Chronic Disease MH - Double-Blind Method MH - Follow-Up Studies MH - Frontal Lobe/*physiopathology MH - Humans MH - Neural Pathways/physiopathology MH - Neurocognitive Disorders/physiopathology/psychology/*surgery MH - Obsessive-Compulsive Disorder/physiopathology/psychology/*surgery MH - Postoperative Complications/physiopathology/psychology MH - Prospective Studies MH - *Psychosurgery MH - Radiosurgery MH - Treatment Outcome RF - 69 EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] AID - 10.1176/jnp.6.4.467 [doi] PST - ppublish SO - J Neuropsychiatry Clin Neurosci. 1994 Fall;6(4):467-77. doi: 10.1176/jnp.6.4.467. PMID- 21951368 OWN - NLM STAT- MEDLINE DCOM- 20120703 LR - 20211020 IS - 1755-5949 (Electronic) IS - 1755-5930 (Print) IS - 1755-5930 (Linking) VI - 17 IP - 5 DP - 2011 Oct TI - Effects of cholinesterase inhibitors in Parkinson's disease dementia: a review of clinical data. PG - 428-41 LID - 10.1111/j.1755-5949.2010.00166.x [doi] AB - AIMS: Cognitive impairment and dementia are common features of Parkinson's disease (PD). Patients with Parkinson's disease dementia (PDD) often have significant cholinergic defects, which may be treated with cholinesterase inhibitors (ChEIs). The objective of this review was to consider available efficacy, tolerability, and safety data from studies of ChEIs in PDD. DISCUSSIONS: A literature search resulted in the identification of 20 relevant publications. Of these, the treatment of PD patients with rivastigmine, donepezil, or galantamine was the focus of six, eleven, and two studies respectively, while one study reported use of both tacrine and donepezil. The majority of studies were small (<40 patients), with the exception of two large randomized controlled trials (RCTs) that are the main focus of this review. In the smaller studies, treatment benefits were reported on a range of outcome measures, though results were extremely variable. While the full results of a large RCT of donepezil in patients with PDD are not yet available, significant treatment differences were reported on the CIBIC-plus at the highest treatment dose. A trend toward improvement was also observed in treated patients on the ADAS-cog. The second large RCT found significant improvements in rivastigmine-treated patients compared with placebo on both the ADAS-cog (P < 0.001) and the ADCS-CGIC (P < 0.007), as well as on all secondary efficacy outcomes. Consequently, rivastigmine is now widely approved for the symptomatic treatment of mild to moderate PDD. CONCLUSIONS: Taken together, these studies suggest that ChEIs are efficacious in the treatment of PDD. CI - © 2010 Blackwell Publishing Ltd. FAU - van Laar, Teus AU - van Laar T AD - Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. t.van.laar@neuro.umcg.n FAU - De Deyn, Peter Paul AU - De Deyn PP FAU - Aarsland, Dag AU - Aarsland D FAU - Barone, Paolo AU - Barone P FAU - Galvin, James E AU - Galvin JE LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20100707 PL - England TA - CNS Neurosci Ther JT - CNS neuroscience & therapeutics JID - 101473265 RN - 0 (Cholinesterase Inhibitors) SB - IM MH - Animals MH - Cholinesterase Inhibitors/*therapeutic use MH - Dementia/*drug therapy/enzymology/*psychology MH - Humans MH - Parkinson Disease/*drug therapy/enzymology/*psychology MH - Randomized Controlled Trials as Topic/methods MH - Treatment Outcome PMC - PMC6493905 COIS- The authors have no conflict of interest. EDAT- 2011/09/29 06:00 MHDA- 2012/07/04 06:00 PMCR- 2010/07/07 CRDT- 2011/09/29 06:00 PHST- 2011/09/29 06:00 [entrez] PHST- 2011/09/29 06:00 [pubmed] PHST- 2012/07/04 06:00 [medline] PHST- 2010/07/07 00:00 [pmc-release] AID - CNS166 [pii] AID - 10.1111/j.1755-5949.2010.00166.x [doi] PST - ppublish SO - CNS Neurosci Ther. 2011 Oct;17(5):428-41. doi: 10.1111/j.1755-5949.2010.00166.x. Epub 2010 Jul 7. PMID- 36754715 OWN - NLM STAT- MEDLINE DCOM- 20231222 LR - 20241230 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 263 DP - 2024 Jan TI - Brain evolution and the meaning of catatonia - An update. PG - 139-150 LID - S0920-9964(23)00038-5 [pii] LID - 10.1016/j.schres.2023.01.026 [doi] AB - Back in 2004, in a chapter titled "Brain Evolution and the Meaning of Catatonia", a case was made that the syndrome's core meaning is embedded in millions of years of vertebrate brain evolution. (Fricchione, 2004) In this update, advances over the last almost 20 years, in catatonia theory and research in particular, and pertinent neuropsychiatry in general, will be applied to this question of meaning. The approach will rely heavily on a number of thought leaders, including Nicos Tinbergen, Paul MacLean, John Bowlby, M. Marsel Mesulam, Bruce McEwen and Karl Friston. Their guidance will be supplemented with a selected survey of 21(sty) century neuropsychiatry, neurophysiology, molecular biology, neuroimaging and neurotherapeutics as applied to the catatonic syndrome. In an attempt to address the question of the meaning of the catatonic syndrome in human life, we will employ two conceptual networks representing the intersubjectivity of the quantitative conceptual network of physical terms and the subjectivity of the qualitative conceptual network of mental and spiritual terms. In the process, a common referent providing extensional identity may emerge (Goodman, 1991). The goal of this exercise is to enhance our attunement with the experience of patients suffering with catatonia. A deeper understanding of catatonia's origins in brain evolution and of the challenges of individual epigenetic development in the setting of environmental events coupled with appreciation of what has been described as the most painful mammalian condition, that of separation, has the potential to foster greater efforts on the part of clinicians to diagnose and treat patients who present with catatonia. In addition, in this ancient and extreme tactic, evolved to provide safety from extreme survival threat, one can speculate what is at the core of human fear and the challenge it presents to all of us. And when the biology, psychology and sociology of catatonia are examined, the nature of solutions to the challenge may emerge. CI - Copyright © 2023 Elsevier B.V. All rights reserved. FAU - Fricchione, Gregory AU - Fricchione G AD - Benson-Henry Institute for Mind Body Medicine Division of Psychiatry and Medicine Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: gfricchione@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20230207 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Humans MH - *Catatonia/diagnosis MH - *Population Health MH - Brain/diagnostic imaging MH - Syndrome MH - Fear OTO - NOTNLM OT - Attachment OT - Catatonia OT - Meaning OT - Neuro-evolution OT - Separation OT - Stress COIS- Conflict of interest Royalties from APA Book: Catatonia. From Psychopathology to Neurobiology Revival Therapeutics: Consultant to new company planning to do catatonia research. EDAT- 2023/02/09 06:00 MHDA- 2023/12/22 06:43 CRDT- 2023/02/08 22:01 PHST- 2022/10/31 00:00 [received] PHST- 2023/01/16 00:00 [revised] PHST- 2023/01/18 00:00 [accepted] PHST- 2023/12/22 06:43 [medline] PHST- 2023/02/09 06:00 [pubmed] PHST- 2023/02/08 22:01 [entrez] AID - S0920-9964(23)00038-5 [pii] AID - 10.1016/j.schres.2023.01.026 [doi] PST - ppublish SO - Schizophr Res. 2024 Jan;263:139-150. doi: 10.1016/j.schres.2023.01.026. Epub 2023 Feb 7. PMID- 36170708 OWN - NLM STAT- MEDLINE DCOM- 20220930 LR - 20221003 IS - 0353-5053 (Print) IS - 0353-5053 (Linking) VI - 34 IP - Suppl 8 DP - 2022 Sep TI - Association between Lifestyle- and Circadian Rhythm-Related Changes, and Different Depression Symptom Clusters during COVID-19. PG - 81-89 AB - BACKGROUND: The COVID-19 pandemic brought along a new situation for the population worldwide. The most important safety measures and lockdown expected extreme adaptability and flexibility impacting mental well-being. The aim of our study was to identify associations between changes in lifestyle and circadian rhythm and depression during the pandemic. SUBJECTS AND METHODS: Our analysis has been carried out on the Hungarian data set of the COMET-G study including information on lifestyle and circadian rhythm-associated factors and severity of depression and its 3 symptom clusters. Associations were assessed using linear regression models adjusted for age and sex. RESULTS: All variables reflecting changes in quality and quantity of sleep showed significant associations with overall depression scores and the three distinct symptom cluster scores. All variables reflecting importance and changes in physical activity during the pandemic were similarly significantly associated with all depression measures. However, only changes in quality of diet, but not quantity was associated with depression scores. CONCLUSIONS: Our results may confirm the association of circadian rhythm and lifestyle-related environmental factors in deterioration of mental health during COVID and help devise prevention and intervention methods and targets for similar situations. FAU - Vadon, Nikolett Beata AU - Vadon NB AD - Department of Psychiatry and Psychotherapy, Semmelweis University, St. Rokus Clinical Centre, Gyulai Pál utca 2., Budapest, 1085, Hungary. FAU - Elek, Livia Priyanka AU - Elek LP FAU - Szigeti, Matyas AU - Szigeti M FAU - Erdelyi-Hamza, Berta AU - Erdelyi-Hamza B FAU - Smirnova, Daria AU - Smirnova D FAU - Fountoulakis, Konstantinos N AU - Fountoulakis KN FAU - Gonda, Xenia AU - Gonda X LA - eng PT - Journal Article PL - Croatia TA - Psychiatr Danub JT - Psychiatria Danubina JID - 9424753 SB - IM MH - *COVID-19/epidemiology/prevention & control/psychology MH - *Circadian Rhythm/physiology MH - Communicable Disease Control MH - *Depression/epidemiology/physiopathology/psychology MH - Female MH - Humans MH - *Life Style MH - Male MH - *Pandemics/prevention & control MH - Risk Factors EDAT- 2022/09/29 06:00 MHDA- 2022/10/01 06:00 CRDT- 2022/09/28 17:32 PHST- 2022/09/28 17:32 [entrez] PHST- 2022/09/29 06:00 [pubmed] PHST- 2022/10/01 06:00 [medline] PST - ppublish SO - Psychiatr Danub. 2022 Sep;34(Suppl 8):81-89. PMID- 18177258 OWN - NLM STAT- MEDLINE DCOM- 20080228 LR - 20080107 IS - 1050-7256 (Print) IS - 1050-7256 (Linking) VI - 17 IP - 12 DP - 2007 Dec TI - The impaired hypothyroid patient: ethical considerations and obligations. PG - 1261-7 LID - 10.1089/thy.2007.0151 [doi] AB - OBJECTIVES: Analyze the ethical duties and dilemmas involved in treating the severely hypothyroid patient. DESIGN: A critical review of the literature was conducted with respect to clinical ethics issues pertaining to severe hypothyroidism; legal and ethical guidelines for consent and capacity in the context of severe hypothyroidism; health case law involving the duty to warn third parties; and comparable clinical conditions resulting in impaired driving and the performance of critical tasks. MAIN OUTCOME: Neuropsychological studies and accepted clinical experiences verify the variable degrees of intellectual and neurological impairment consequent to severe hypothyroidism. Thus, severely hypothyroid patients are considered impaired in the performance of specific tasks, such as driving. Consequent to that, they may be agents of harm as a result of their impairment if they are not warned against driving or performing other duties affecting public safety. Severely hypothyroid patients may lack the capacity to make an informed decision, even when warned against driving or other tasks, and some may ignore such warnings. CONCLUSIONS: The legal and ethical "duty to warn" may trump confidentiality and HIPAA in cases where the activity of impaired patients seriously affects public safety. Not only do health care providers have a clear duty to warn patients not to drive, but in some extreme cases, may have a duty to warn third parties when a patient's driving or occupational duties place the public in harm's way. FAU - Rosenthal, M Sara AU - Rosenthal MS AD - Program for Bioethics and Patients' Rights, University of Kentucky College of Medicine, Lexington, Kentucky 04536-0086, USA. msrose2@email.uky.edu LA - eng PT - Journal Article PT - Review PL - United States TA - Thyroid JT - Thyroid : official journal of the American Thyroid Association JID - 9104317 SB - IM MH - Automobile Driving/psychology MH - Duty to Warn/*ethics/legislation & jurisprudence MH - Ethics, Medical MH - Humans MH - Hypothyroidism/*complications/diagnosis/psychology MH - Psychomotor Disorders/diagnosis/*etiology/psychology MH - Safety MH - Task Performance and Analysis RF - 59 EDAT- 2008/01/08 09:00 MHDA- 2008/02/29 09:00 CRDT- 2008/01/08 09:00 PHST- 2008/01/08 09:00 [pubmed] PHST- 2008/02/29 09:00 [medline] PHST- 2008/01/08 09:00 [entrez] AID - 10.1089/thy.2007.0151 [doi] PST - ppublish SO - Thyroid. 2007 Dec;17(12):1261-7. doi: 10.1089/thy.2007.0151. PMID- 39470087 OWN - NLM STAT- MEDLINE DCOM- 20241029 LR - 20241029 IS - 1369-1627 (Electronic) IS - 0954-0261 (Linking) VI - 36 IP - 4-5 DP - 2024 Jun-Aug TI - Suicide among migrants: a comprehensive narrative review of literature. PG - 413-423 LID - 10.1080/09540261.2024.2327389 [doi] AB - Suicidality among migrants represents a multifaceted and complex issue with significant implications and challenges for public mental health and policies. This narrative review aims to explore the factors contributing to suicidality within the migrant groups, consequently highlighting the need for tailored interventions and supporting strategies. Firstly, we reviewed the evidences on the prevalence of suicidal ideation, attempted suicides, and deaths by suicide among migrants. The results were extremely heterogeneous, mostly depending on the different migrant group considered. Significant differences in suicide risk have been found depending on the legal status of migrants and their country of origin/migration. The second section explored the protective and risk factors for suicidal ideation and behaviours in different migrant groups. The analysis concluded that a set of factors may interact in various ways, contributing to a heterogeneous and complex framework underpinning the phenomenon of suicide. Migration itself may be a challenging and traumatizing experience, characterized by social isolation, cultural dislocation and adjustment, as well as economic and financial distress, all of which may exacerbate pre-existing mental health vulnerabilities or trigger new mental disorders. Acculturative stress, discrimination, and language barriers further compound these challenges, often hindering access to mental health services. FAU - Spataro, Gaspare AU - Spataro G AUID- ORCID: 0009-0009-8131-4610 AD - Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. FAU - Ventriglio, Antonio AU - Ventriglio A AUID- ORCID: 0000-0002-3934-7007 AD - Department of Clinical and Experimental medicine, University of Foggia, Foggia, Italy. FAU - Signorelli, Maria Salvina AU - Signorelli MS AUID- ORCID: 0000-0001-5835-4176 AD - Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy. FAU - Marrazzo, Giovanna AU - Marrazzo G AUID- ORCID: 0009-0002-9748-5982 AD - UOC Psichiatria Azienda Ospedaliera Universitaria Paolo Giaccone, Palermo, Italy. LA - eng PT - Journal Article PT - Review DEP - 20240312 PL - England TA - Int Rev Psychiatry JT - International review of psychiatry (Abingdon, England) JID - 8918131 SB - IM MH - Humans MH - *Transients and Migrants/psychology/statistics & numerical data MH - *Suicide/statistics & numerical data/ethnology MH - Suicidal Ideation MH - Risk Factors MH - Suicide, Attempted/statistics & numerical data OAB - The prevalence of suicidal ideation and behaviour among migrant populations consistently varies across studies, mostly depending on the different characteristics of the various subgroups of migrants sampled.Literature comparing suicide risk among migrants and the native populations of the host countries has shown contrasting findings.Some studies have suggested that refugees report a higher risk of suicide compared to the general population but also to other migrant groups.Studies focused on asylum seekers have suggested that this group reports a particularly higher suicide risk than the native population of the hosting country.Migrants seem to carry with them the suicide risk rate registered in their homeland. In fact, migrants from countries with a high baseline suicide rate (i.e. Northern and Eastern European countries) are at higher risk of suicide attempts and death by suicide; nonetheless, over time, their risk rates tend to overlap with those of the country of migration.Factors that protect or predispose individuals to suicidality may differ between ethnic groups.Conflicts and war-related traumatic experiences, irrespectively of the presence of mental disorders, are common risk factors for suicidal ideation among refugees.Research suggests that second-generation migrants are more likely to exhibit suicidal behaviors compared to first-generation migrants.Migrant mothers may be a particularly vulnerable group, as they are less likely to seek help from professional services due to various barriers, including stigma, language, poor knowledge of community services, and prioritizing their children’s needs.Poor living conditions are associated with an increased prevalence of mental disorders and suicidal behaviour among migrants. Concerns about safety and lack of shelter, food, water, clothing, and toilets were all associated with higher rates of PTSD symptoms and suicidal ideation.Migrants face several challenges in accessing mental health treatments, including stigma, language barriers and distrust due to the lack of cultural-competent and gender-sensitive assistance. OABL- eng OTO - NOTNLM OT - Suicide OT - acculturation OT - discrimination OT - migrants OT - migration OT - suicidal attempts OT - suicidal ideation EDAT- 2024/10/29 16:14 MHDA- 2024/10/29 16:15 CRDT- 2024/10/29 08:03 PHST- 2024/10/29 16:15 [medline] PHST- 2024/10/29 16:14 [pubmed] PHST- 2024/10/29 08:03 [entrez] AID - 10.1080/09540261.2024.2327389 [doi] PST - ppublish SO - Int Rev Psychiatry. 2024 Jun-Aug;36(4-5):413-423. doi: 10.1080/09540261.2024.2327389. Epub 2024 Mar 12. PMID- 35545555 OWN - NLM STAT- MEDLINE DCOM- 20220802 LR - 20220922 IS - 1880-8026 (Electronic) IS - 0019-8366 (Print) IS - 0019-8366 (Linking) VI - 60 IP - 4 DP - 2022 Jul 31 TI - Strategies to manage working from home during the pandemic: the employee experience. PG - 319-333 LID - 10.2486/indhealth.2022-0042 [doi] AB - Many Australian workers were mandated to work from home during the COVID-19 pandemic. Using a qualitative approach, this study aimed to identify optimal work from home management strategies, by analysing the experience of Australian employees working from home (WFH) during this time. A purposive sample, drawn from the Australian Employees Working from Home Study, of managers and non-managers from a range of sectors, was invited to participate in focus groups. Data were analysed using thematic analysis and mapped to the work-systems framework approach to determine strategies implemented to support WFH. Most participants' experiences were more negative than positive, in part due to extreme lockdowns including curfews, with childcare and school closures compounding their WFH experiences. Effective workplace-initiated strategies to optimise WFH included: management support of flexible work hours; provision of necessary equipment with ICT support; regular online communication; performance management adjustments; and manager training. FAU - Oakman, Jodi AU - Oakman J AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Kinsman, Natasha AU - Kinsman N AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Graham, Melissa AU - Graham M AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. AD - Department of Public Health, La Trobe University, Australia. FAU - Stuckey, Rwth AU - Stuckey R AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Weale, Victoria AU - Weale V AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. LA - eng PT - Journal Article DEP - 20220511 PL - Japan TA - Ind Health JT - Industrial health JID - 2985065R SB - IM MH - Australia MH - *COVID-19/epidemiology MH - Communicable Disease Control MH - Humans MH - *Pandemics/prevention & control MH - Workplace PMC - PMC9453551 OTO - NOTNLM OT - Australian workforce OT - COVID-19 OT - Management OT - Wellbeing OT - Work health and Safety OT - Working from home COIS- The authors declare there are no conflicts of interest. EDAT- 2022/05/12 06:00 MHDA- 2022/08/03 06:00 PMCR- 2022/07/01 CRDT- 2022/05/11 22:13 PHST- 2022/05/12 06:00 [pubmed] PHST- 2022/08/03 06:00 [medline] PHST- 2022/05/11 22:13 [entrez] PHST- 2022/07/01 00:00 [pmc-release] AID - 2022-0042 [pii] AID - 10.2486/indhealth.2022-0042 [doi] PST - ppublish SO - Ind Health. 2022 Jul 31;60(4):319-333. doi: 10.2486/indhealth.2022-0042. Epub 2022 May 11. PMID- 32658879 OWN - NLM STAT- MEDLINE DCOM- 20200724 LR - 20201218 IS - 2038-1840 (Electronic) IS - 0034-1193 (Linking) VI - 111 IP - 7 DP - 2020 Jul-Aug TI - [Remote patient monitoring in dialysis patients: the "change of pace" for home dialysis.]. PG - 404-410 LID - 10.1701/3407.33922 [doi] AB - Lockdown and self-isolation are to date the only solution to limit the spread of recent outbreak of coronavirus disease (CoViD-19), highlighting the great advantage of home dialysis in a patient otherwise forced to travel from / to the dialysis center to receive this "life-saving" treatment. Indeed, to prevent spreading of CoViD-19 infection among extremely fragile dialysis patients, as well as among dialysis workers, hemodialysis (HD) centers are adopting specific procedures ("dedicated" dialysis facilities, portable osmosis, etc.) with a great economic and organizational commitment. Peritoneal dialysis (PD) represents a type of home dialysis therapy not yet adequately implemented to date, in spite of safe and simple practice, as well as similar dialytic efficiency vs in-center hemodialysis. Remote patient monitoring (RPM) systems have been developed in automated PD (APD) cyclers in order to improve the acceptance of this dialysis method, to increase the compliance to the prescribed therapy and to control treatment adequacy. In this review we assess the potential advantages of RPM in APD, that are the chance for patients to acquire greater independence and safety in the home treatment, to allow better access to care for residents in remote areas, faster resolution of problems, reduction in hospitalizations and mortality rates, as well as time and cost saving for both the patient and the staff. The use of medical devices (sphygmomanometer, glucometer, balance, etc.), connected by wireless to the clinician's portal, might also allow a wider diffusion of incremental dialysis, an integrated therapy that combines conservative management of ESKD patients with a soft dialysis based on the residual kidney function and symptomatology, with potential prognosis and economic benefits. Although the majority of the studies are small and observational, a wider use of RPM systems is desirable to broaden the spread of home dialysis, as we learnt from Coronavirus pandemic. FAU - Borrelli, Silvio AU - Borrelli S AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. FAU - Frattolillo, Vittoria AU - Frattolillo V AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. FAU - Garofalo, Carlo AU - Garofalo C AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. FAU - Provenzano, Michele AU - Provenzano M AD - Cattedra di Nefrologia, Università Magna Grecia, Catanzaro. FAU - Genualdo, Raffaele AU - Genualdo R AD - Unità di Nefrologia, Ospedale dei Pellegrini, Napoli. FAU - Conte, Giuseppe AU - Conte G AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. FAU - Minutolo, Roberto AU - Minutolo R AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. FAU - De Nicola, Luca AU - De Nicola L AD - Cattedra di Nefrologia, Università della Campania Luigi Vanvitelli, Napoli. LA - ita PT - Journal Article PT - Review TT - Monitoraggio da remoto del paziente in dialisi: il cambio di passo per la dialisi domiciliare? PL - Italy TA - Recenti Prog Med JT - Recenti progressi in medicina JID - 0401271 SB - IM MH - Automation MH - *Betacoronavirus MH - COVID-19 MH - *Coronavirus Infections/prevention & control MH - Cost Savings MH - Disease Susceptibility MH - Health Services Accessibility MH - *Hemodialysis, Home/economics/methods MH - Humans MH - Kidney Failure, Chronic/psychology/therapy MH - Monitoring, Physiologic/instrumentation/*methods MH - *Pandemics/prevention & control MH - Patient Compliance MH - Peritoneal Dialysis/instrumentation/methods MH - *Pneumonia, Viral/prevention & control MH - Precision Medicine MH - SARS-CoV-2 MH - Social Isolation MH - Telemedicine EDAT- 2020/07/14 06:00 MHDA- 2020/07/25 06:00 CRDT- 2020/07/14 06:00 PHST- 2020/07/14 06:00 [entrez] PHST- 2020/07/14 06:00 [pubmed] PHST- 2020/07/25 06:00 [medline] AID - 10.1701/3407.33922 [doi] PST - ppublish SO - Recenti Prog Med. 2020 Jul-Aug;111(7):404-410. doi: 10.1701/3407.33922. PMID- 30095359 OWN - NLM STAT- MEDLINE DCOM- 20190724 LR - 20190724 IS - 1464-0678 (Electronic) IS - 1357-650X (Linking) VI - 24 IP - 3 DP - 2019 May TI - Atypical maternal cradling laterality in an impoverished South African population. PG - 320-341 LID - 10.1080/1357650X.2018.1509077 [doi] AB - Human studies consistently report a 60%-80% maternal left cradling preference. The dominant explanation points to an engagement of the emotionally more-attuned right brain. In contrast, we found equal incidences of left (31.3%), right (34.3%) and no-preference (34.3%) cradling in an impoverished South African population living under adverse conditions characterized by extreme dangers. We found striking differences on the Parenting Stress Index (PSI) between mothers with no cradling laterality preference and mothers with either a left or right preference. In several mammals a homologous left preference becomes stronger when acute threats prevail, rendering the rightwards shift we observed under dangerous conditions seemingly paradoxical. We propose this paradox can be resolved in terms of life-history strategy theory which predicts reduced parental investment in chronically dangerous environments. We interpret our high PSI score findings in no-preference cradlers as indicative of poorer, or at least ambivalent, maternal coping which many studies show is typically associated with reduced emotional sensitivity and responsiveness. We suggest that the latter may be a psychological mechanism mediating a partial withdrawal of parental investment in response to an enduringly adverse environment. To the best of our knowledge, this is the first study investigating cradling laterality preferences in an adverse socioeconomic environment. FAU - Morgan, Barak AU - Morgan B AUID- ORCID: 0000-0002-9380-431X AD - a Global Risk Governance Programme, Institute for Safety Governance and Criminology, Law Faculty , University of Cape Town , Cape Town , South Africa. FAU - Hunt, Xanthe AU - Hunt X AUID- ORCID: 0000-0001-7531-6665 AD - b Department of Psychology , Stellenbosch University , Stellenbosch , South Africa. FAU - Sieratzki, Jechil AU - Sieratzki J AD - c Human Communication Science , University College London , London , UK. FAU - Woll, Bencie AU - Woll B AUID- ORCID: 0000-0002-3300-4775 AD - d Division of Psychology and Language Sciences , University College London , London , UK. FAU - Tomlinson, Mark AU - Tomlinson M AUID- ORCID: 0000-0001-5846-3444 AD - e Department of Psychology , Stellenbosch University , Stellenbosch , South Africa. AD - f Institute of Child and Adolescent Health Research , Stellenbosch University , Stellenbosch , South Africa. LA - eng PT - Journal Article PT - Observational Study DEP - 20180810 PL - England TA - Laterality JT - Laterality JID - 9609064 MH - Arm MH - Bottle Feeding MH - Breast Feeding MH - Choice Behavior MH - Depression/epidemiology/physiopathology MH - *Functional Laterality MH - Humans MH - Infant MH - Infant, Newborn MH - Maternal Behavior/physiology/*psychology MH - Mothers/psychology MH - Motor Activity/physiology MH - Poverty/*psychology MH - Prevalence MH - Socioeconomic Factors MH - *Stress, Psychological/epidemiology/physiopathology OTO - NOTNLM OT - Cradling OT - infant OT - maternal OT - parenting stress index OT - poverty EDAT- 2018/08/11 06:00 MHDA- 2019/07/25 06:00 CRDT- 2018/08/11 06:00 PHST- 2018/08/11 06:00 [pubmed] PHST- 2019/07/25 06:00 [medline] PHST- 2018/08/11 06:00 [entrez] AID - 10.1080/1357650X.2018.1509077 [doi] PST - ppublish SO - Laterality. 2019 May;24(3):320-341. doi: 10.1080/1357650X.2018.1509077. Epub 2018 Aug 10. PMID- 23568375 OWN - NLM STAT- MEDLINE DCOM- 20140116 LR - 20211021 IS - 1179-2035 (Electronic) IS - 0112-1642 (Linking) VI - 43 IP - 6 DP - 2013 Jun TI - Crawling to the finish line: why do endurance runners collapse? Implications for understanding of mechanisms underlying pacing and fatigue. PG - 413-24 LID - 10.1007/s40279-013-0044-y [doi] AB - Effective regulation of pace enables the majority of runners to complete competitive endurance events without mishap. However, some runners do experience exercise-induced collapse associated with postural hypotension, which in rare cases results from life-threatening conditions such as cardiac disorders, cerebral events, heat stroke and hyponatraemia. Despite the experience of either catastrophic system failure or extreme peripheral muscle fatigue, some runners persist in attempting to reach the finish line, and this often results in a sequence of dynamic changes in posture and gait that we have termed the 'Foster collapse positions'. The initial stage involves an unstable gait and the runner assumes the 'Early Foster' collapse position with hips slightly flexed and their head lowered. This unstable gait further degrades into a shuffle referred to as the 'Half Foster' collapse position characterized by hip flexion of approximately 90° with the trunk and head parallel to the ground. At this point, the muscles of postural support and the co-ordination of propulsion begin to be compromised. If the condition worsens, the runner will fall to the ground and assume the 'Full Foster' collapse position, which involves crawling forwards on knees and elbows towards the finish line, with their trunk angled such that the head is at a lower angle than the hips. Upon reaching the finish line, or sometimes before that, the runner may collapse and remain prone until recovering either with or without assistance or medical treatment. The Foster collapse positions are indicative of a final, likely primordial, protective mechanism designed to attenuate postural hypotension, cardiac 'pump' insufficiency or cerebral blood flow deficiency. Continuing to attempt to reach the finish line in this impaired state is also perhaps indicative of a high psychological drive or a variety of neurological and psychological pathologies such as diminished sensitivity to interoceptive feedback, unrealistic situational appraisal or extreme motivational drives. A better understanding of the physiological, neurological and psychological antecedents of the Foster collapse sequence remains an important issue with practical implications for runner safety and theoretical understanding of collapses during exercise. FAU - St Clair Gibson, Alan AU - St Clair Gibson A AD - Department of Sport and Exercise Sciences, Sport, Exercise and Wellbeing Research Centre, Faculty of Health and Life Sciences, Northumbria University, Northumberland Road, Newcastle upon Tyne, NE1 8ST, UK. a.stclairgibson@northumbria.ac.uk FAU - De Koning, Jos J AU - De Koning JJ FAU - Thompson, Kevin G AU - Thompson KG FAU - Roberts, William O AU - Roberts WO FAU - Micklewright, Dominic AU - Micklewright D FAU - Raglin, John AU - Raglin J FAU - Foster, Carl AU - Foster C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM MH - Athletes/*psychology MH - Exercise/*physiology/psychology MH - Fatigue/*physiopathology/psychology MH - Humans MH - Physical Endurance/*physiology MH - Posture MH - Running/*physiology/psychology EDAT- 2013/04/10 06:00 MHDA- 2014/01/17 06:00 CRDT- 2013/04/10 06:00 PHST- 2013/04/10 06:00 [entrez] PHST- 2013/04/10 06:00 [pubmed] PHST- 2014/01/17 06:00 [medline] AID - 10.1007/s40279-013-0044-y [doi] PST - ppublish SO - Sports Med. 2013 Jun;43(6):413-24. doi: 10.1007/s40279-013-0044-y. PMID- 11692973 OWN - NLM STAT- MEDLINE DCOM- 20011207 LR - 20170214 IS - 0706-7437 (Print) IS - 0706-7437 (Linking) VI - 46 IP - 8 DP - 2001 Oct TI - The use of electroconvulsive therapy in special patient populations. PG - 710-9 AB - BACKGROUND: Despite its well-established efficacy and its increasing use, electroconvulsive therapy (ECT) remains a controversial treatment. Lack of clarity in the issues related to its use in special patient populations (for example, in children, in adolescents, in pregnant women, in the elderly, and in the medically ill) often contributes to the debate about the use of ECT. METHOD: The literature on ECT use in special patient populations is reviewed, together with the commonly associated high-risk medical conditions in clinical practice. Specific reference is made in each case to the safety, tolerability, and efficacy of the procedure. RESULTS: Much of the literature surveyed consists of case studies, although a few controlled trials are available. In general, ECT use in special populations is relatively safe and extremely effective. In small case series, ECT use in children and adolescents is effective but requires further systematic study. In pregnant women, ECT is very effective, and with proper medical care, it is relatively safe in all trimesters of pregnancy, as well as in the postpartum period. The frail elderly are particularly good candidates for ECT because they are often unresponsive to or intolerant of psychotropic medication. Medical conditions that should receive particular attention during a course of ECT are disorders of the central nervous system (CNS), cardiovascular, and respiratory system. With modern anesthesia techniques and careful medical management of each high-risk patient, most can successfully complete a course of ECT. The process of obtaining informed consent also requires special consideration in this group of patients because their capacity to consent to treatment may be compromised. CONCLUSIONS: With careful attention to each patient's medical and anesthesia needs, ECT is an effective and relatively safe procedure in high-risk special patient populations. FAU - Rabheru, K AU - Rabheru K AD - Department of Psychiatry, University of Western Ontario, London, Ontario. LA - eng PT - Journal Article PT - Review PL - United States TA - Can J Psychiatry JT - Canadian journal of psychiatry. Revue canadienne de psychiatrie JID - 7904187 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Brain Neoplasms/*psychology MH - Cardiovascular Diseases/*psychology MH - Child MH - Chronic Disease/psychology MH - Depression, Postpartum/*therapy MH - Depressive Disorder/*etiology/therapy MH - Electroconvulsive Therapy/*methods MH - Female MH - Humans MH - Informed Consent MH - Male MH - Pregnancy MH - Pregnancy Complications MH - Treatment Outcome RF - 169 EDAT- 2001/11/06 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/11/06 10:00 PHST- 2001/11/06 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/11/06 10:00 [entrez] AID - 10.1177/070674370104600803 [doi] PST - ppublish SO - Can J Psychiatry. 2001 Oct;46(8):710-9. doi: 10.1177/070674370104600803. PMID- 15273477 OWN - NLM STAT- MEDLINE DCOM- 20041005 LR - 20191026 IS - 0730-4625 (Print) IS - 0730-4625 (Linking) VI - 23 IP - 4 DP - 2004 Jul-Aug TI - Posttraumatic stress disorder and the intensive care unit patient: implications for staff and advanced practice critical care nurses. PG - 145-50; quiz 151-2 AB - Posttraumatic Stress Disorder (PTSD) is a rather common psychiatric diagnosis, and potentially is a very debilitating disorder. In PTSD, patients exhibit specific debilitating symptoms in response to exposure to an extreme stressor. Conditions in the intensive care unit (ICU) can exacerbate previously diagnosed newly developed PTSD, and in some cases cause PTSD. This diagnosis potentially puts both the patient and nursing staff at increased risk for harm, and is associated with increased utilization of medical services. Critical care staff and APNs can take actions to screen for at-risk patients, emplace safety protocols, and advocate for affected patients within the healthcare team. FAU - Baxter, Andrew AU - Baxter A AD - Arizona State University School of Nursing, AZ, USA. telliott4@nc.rr.com LA - eng PT - Journal Article PT - Review PL - United States TA - Dimens Crit Care Nurs JT - Dimensions of critical care nursing : DCCN JID - 8211489 MH - Costs and Cost Analysis MH - Critical Care/economics/methods/*psychology MH - Critical Illness/economics/nursing/psychology MH - Female MH - Humans MH - Intensive Care Units MH - Middle Aged MH - Prevalence MH - Recurrence MH - Stress Disorders, Post-Traumatic/epidemiology/psychology/therapy RF - 27 EDAT- 2004/07/27 05:00 MHDA- 2004/10/06 09:00 CRDT- 2004/07/27 05:00 PHST- 2004/07/27 05:00 [pubmed] PHST- 2004/10/06 09:00 [medline] PHST- 2004/07/27 05:00 [entrez] AID - 00003465-200407000-00001 [pii] AID - 10.1097/00003465-200407000-00001 [doi] PST - ppublish SO - Dimens Crit Care Nurs. 2004 Jul-Aug;23(4):145-50; quiz 151-2. doi: 10.1097/00003465-200407000-00001. PMID- 34197293 OWN - NLM STAT- MEDLINE DCOM- 20210707 LR - 20210707 IS - 1929-6355 (Electronic) IS - 1910-622X (Linking) VI - 34 IP - 2 DP - 2021 Jun TI - An Academic Health Sciences Centre's Strategy to Enhance Nurse Resilience and Psychological Safety. PG - 39-44 LID - cjnl.2021.26531 [pii] LID - 10.12927/cjnl.2021.26531 [doi] AB - The rapid cadence of change and the fear of acquiring and spreading COVID-19 - coupled with moral distress exacerbated by fulfilling one's duty to care under extremely challenging conditions - continue to impact nurses' coping ability, resilience and psychological safety globally (McDougall et al. 2020). This paper provides an overview of how an academic health sciences centre (AHSC) has responded to the evolving waves of the COVID-19 pandemic. Specifically, we share our context and the strategies we used to build and enhance nurse resilience and psychological safety at the organizational, clinical team and individual levels. This is followed by a description of our nurses' achievements amid the pandemic. CI - Copyright © 2021 Longwoods Publishing. FAU - Jeffs, Lianne AU - Jeffs L AD - Research and Innovation Lead Scholar in Residence, Nursing and Health Disciplines, Senior Clinician Scientist, Lunenfeld-Tanenbaum Research, Sinai Health, Associate Professor, Bloomberg Faculty of Nursing, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON. FAU - Merkley, Jane AU - Merkley J AD - Executive Vice President, Chief Nurse, Executive and Chief Operating Officer, Sinai Health, Toronto, ON. FAU - Greenberg, Rebecca AU - Greenberg R AD - Senior Bioethicist, Sinai Health, Associate Professor, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON. FAU - Ginty, Leanne AU - Ginty L AD - Director, Professional Practice, Nursing, Sinai Health, Toronto, ON. FAU - Amaral, Nely AU - Amaral N AD - Director, Nursing, Quality and Performance, Magnet Program Director, Sinai Health, Toronto, ON. FAU - Maunder, Robert AU - Maunder R AD - Chair in Health and Behaviour, Deputy Psychiatrist-in-Chief and Head of Psychiatry Research, Sinai Health, Professor, Department of Psychiatry, University of Toronto, Toronto, ON. FAU - Wiesenfeld, Lesley AU - Wiesenfeld L AD - Psychiatrist-in-Chief Head, Geriatric Psychiatry Consultation, Liaison Service, Sinai Health, Associate Professor, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON. FAU - Brown, Susan AU - Brown S AD - Executive Vice President, People & Culture, Chief Human Resources Officer, Sinai Health, Toronto, ON. FAU - Shing, Paula AU - Shing P AD - Interim Director, Professional Practice and Education, Nursing and Health Disciplines, Sinai Health, Toronto, ON. FAU - Ronald, Kara AU - Ronald K AD - Vice President, Professional Practice, Nursing and Health Disciplines, Sinai Health, Toronto, ON. LA - eng PT - Journal Article PL - Canada TA - Nurs Leadersh (Tor Ont) JT - Nursing leadership (Toronto, Ont.) JID - 101470760 MH - Academic Medical Centers/organization & administration MH - *Adaptation, Psychological MH - COVID-19/epidemiology/*nursing MH - Humans MH - Leadership MH - Nursing Staff, Hospital/*organization & administration/psychology MH - Pandemics MH - Patient Care Team/organization & administration MH - *Resilience, Psychological MH - SARS-CoV-2 EDAT- 2021/07/02 06:00 MHDA- 2021/07/08 06:00 CRDT- 2021/07/01 17:17 PHST- 2021/07/01 17:17 [entrez] PHST- 2021/07/02 06:00 [pubmed] PHST- 2021/07/08 06:00 [medline] AID - cjnl.2021.26531 [pii] AID - 10.12927/cjnl.2021.26531 [doi] PST - ppublish SO - Nurs Leadersh (Tor Ont). 2021 Jun;34(2):39-44. doi: 10.12927/cjnl.2021.26531. PMID- 31362512 OWN - NLM STAT- MEDLINE DCOM- 20200403 LR - 20200403 IS - 1445-6354 (Electronic) IS - 1445-6354 (Linking) VI - 19 IP - 3 DP - 2019 Jul TI - 'We have to drive everywhere': rural nurses and their precepted students. PG - 5347 LID - 10.22605/RRH5347 [doi] AB - INTRODUCTION: Travel safety culture is a vital aspect of nursing in rural western Canada, where long distances and severe weather are commonplace. However, this culture is poorly understood owing to the absence of official policy, and the tendency of rural nurses to take travel risks and burdens in stride, rather than advocating for change. Travel risks and burdens include extreme weather events such as tornadoes and blizzards; unmarked routes and hazards; distance, time and expense; and driver fatigue. In such rural settings, the safety and health of visitors, novices and students are of particular concern. The researchers sought to elicit the tacit knowledge of rural registered nurses, and their students undertaking rural nursing preceptorships, pertaining to rural travel issues and best practices for safety and wellbeing. METHODS: Through purposive and snowball sampling, the researchers recruited seven senior nursing students and five nurse preceptors. Seven rural acute and community care sites, between 42 km and 416 km distant from the students' primary place of study, were covered by the study. Photovoice, a participant action modality, was employed to collect photographic and qualitative interview data from participants over 10 weeks, between February and April 2016. The data were analyzed thematically, in collaboration with participants, who in turn validated the results. A digital storytelling initiative was attempted, to further involve participants in dissemination of findings, but only one participant took part in this phase of the project. RESULTS: The central finding of the study was that nursing students learn to accept and manage limitations - and to recognize and capitalize on opportunities - when undertaking rural preceptorships. With regard to road safety, the students were found to be particularly vulnerable to long distances, hazardous conditions, fuel and cellular data expenses, and fatigue. These issues were compounded by the students' reluctance to speak up, or to miss shifts, when they felt unsafe or unwell. Their preceptors role modeled autonomy and community ethos as the foundations of a frontline, extemporaneous road safety culture. This entailed personal safety measures borne from rural experience and background, familiarity with the countryside, and community connectedness with other healthcare sites in place of any official public alert system. The preceptors furthermore benefited from strong union protection for occupational health and safety concerns, but students being taught in rural settings had no such advantage. CONCLUSIONS: Nursing students should have the same occupational health and safety protections as their rural preceptors, especially the right to refuse travel, without penalty, in unsafe circumstances. Better travel subsidies and road safety measures during rural preceptorship may help increase the likelihood of students considering a rural career path. Furthermore, the frontline, community-based road safety experience of rural nurses is an untapped source of information for educators and policymakers. Such information will become more and more vital as a diminishing number of rural nurses are called upon to care for an aging client base. FAU - Yonge, Olive AU - Yonge O AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada olive.yonge@ualberta.ca. FAU - Jackman, Deirdre AU - Jackman D AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada deirdre.jackman@ualberta.ca. FAU - Luhanga, Florence AU - Luhanga F AD - Faculty of Nursing, Research and Innovation Centre, Room 508, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, S4S 0A2, Canada florence.luhanga@uregina.ca. FAU - Myrick, Florence AU - Myrick F AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada amyrick@ualberta.ca. FAU - Oosterbroek, Tracy AU - Oosterbroek T AD - Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada tracy.oosterbroek@uleth.ca. FAU - Foley, Vicki AU - Foley V AD - Association of Registered Nurses of Prince Edward Island, Unit 6 - 161 Maypoint Rd., Charlottetown, Prince Edward Island, C1E 1X6, Canada vfoley@upei.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190731 PL - Australia TA - Rural Remote Health JT - Rural and remote health JID - 101174860 SB - IM MH - Automobile Driving/psychology MH - Canada MH - Geographic Information Systems MH - Humans MH - Interviews as Topic MH - Occupational Health MH - *Preceptorship MH - *Rural Health Services MH - Rural Population MH - *Students, Nursing/psychology MH - Travel OTO - NOTNLM OT - Photovoice OT - occupational health and safety OT - participant action research OT - preceptorship OT - roads OT - rural nursing OT - weather OT - Canada EDAT- 2019/08/01 06:00 MHDA- 2020/04/04 06:00 CRDT- 2019/08/01 06:00 PHST- 2019/08/01 06:00 [entrez] PHST- 2019/08/01 06:00 [pubmed] PHST- 2020/04/04 06:00 [medline] AID - 5347 [pii] AID - 10.22605/RRH5347 [doi] PST - ppublish SO - Rural Remote Health. 2019 Jul;19(3):5347. doi: 10.22605/RRH5347. Epub 2019 Jul 31. PMID- 23929092 OWN - NLM STAT- MEDLINE DCOM- 20131118 LR - 20211021 IS - 1535-7228 (Electronic) IS - 0002-953X (Print) IS - 0002-953X (Linking) VI - 170 IP - 10 DP - 2013 Oct TI - Response to learned threat: An FMRI study in adolescent and adult anxiety. PG - 1195-204 LID - 10.1176/appi.ajp.2013.12050651 [doi] AB - OBJECTIVE: Poor threat-safety discrimination reflects prefrontal cortex dysfunction in adult anxiety disorders. While adolescent anxiety disorders are impairing and predict high risk for adult anxiety disorders, the neural correlates of threat-safety discrimination have not been investigated in this population. The authors compared prefrontal cortex function in anxious and healthy adolescents and adults following conditioning and extinction, processes requiring threat-safety learning. METHOD: Anxious and healthy adolescents and adults (N=114) completed fear conditioning and extinction in the clinic. The conditioned stimuli (CS+) were neutral faces, paired with an aversive scream. Physiological and subjective data were acquired. Three weeks later, 82 participants viewed the CS+ and morphed images resembling the CS+ in an MRI scanner. During scanning, participants made difficult threat-safety discriminations while appraising threat and explicit memory of the CS+. RESULTS: During conditioning and extinction, the anxious groups reported more fear than the healthy groups, but the anxious adolescent and adult groups did not differ on physiological measures. During imaging, both anxious adolescents and adults exhibited lower activation in the subgenual anterior cingulate cortex than their healthy counterparts, specifically when appraising threat. Compared with their age-matched counterpart groups, anxious adults exhibited reduced activation in the ventromedial prefrontal cortex when appraising threat, whereas anxious adolescents exhibited a U-shaped pattern of activation, with greater activation in response to the most extreme CS+ and CS-. CONCLUSIONS: Two regions of the prefrontal cortex are involved in anxiety disorders. Reduced subgenual anterior cingulate cortex engagement is a shared feature in adult and adolescent anxiety disorders, but ventromedial prefrontal cortex dysfunction is age-specific. The unique U-shaped pattern of activation in the ventromedial prefrontal cortex in many anxious adolescents may reflect heightened sensitivity to threat and safety conditions. How variations in the pattern relate to later risk for adult illness remains to be determined. FAU - Britton, Jennifer C AU - Britton JC FAU - Grillon, Christian AU - Grillon C FAU - Lissek, Shmuel AU - Lissek S FAU - Norcross, Maxine A AU - Norcross MA FAU - Szuhany, Kristin L AU - Szuhany KL FAU - Chen, Gang AU - Chen G FAU - Ernst, Monique AU - Ernst M FAU - Nelson, Eric E AU - Nelson EE FAU - Leibenluft, Ellen AU - Leibenluft E FAU - Shechner, Tomer AU - Shechner T FAU - Pine, Daniel S AU - Pine DS LA - eng GR - K99 MH091183/MH/NIMH NIH HHS/United States GR - R00 MH091183/MH/NIMH NIH HHS/United States GR - Z99 MH999999/Intramural NIH HHS/United States GR - K99-MH-091183/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PL - United States TA - Am J Psychiatry JT - The American journal of psychiatry JID - 0370512 SB - IM MH - Adolescent MH - Adult MH - Anxiety Disorders/diagnosis/*physiopathology/psychology MH - Arousal/*physiology MH - Brain Mapping MH - Conditioning, Classical/*physiology MH - Discrimination, Psychological MH - Extinction, Psychological/physiology MH - Facial Expression MH - Fear/*physiology MH - Female MH - Humans MH - *Image Interpretation, Computer-Assisted MH - *Magnetic Resonance Imaging MH - Male MH - Mental Recall/physiology MH - Pattern Recognition, Visual/physiology MH - Prefrontal Cortex/*physiopathology MH - Young Adult PMC - PMC3790858 MID - NIHMS474482 COIS- Disclosures All authors report no competing interests. EDAT- 2013/08/10 06:00 MHDA- 2013/11/19 06:00 PMCR- 2014/10/01 CRDT- 2013/08/10 06:00 PHST- 2013/08/10 06:00 [entrez] PHST- 2013/08/10 06:00 [pubmed] PHST- 2013/11/19 06:00 [medline] PHST- 2014/10/01 00:00 [pmc-release] AID - 1725885 [pii] AID - 10.1176/appi.ajp.2013.12050651 [doi] PST - ppublish SO - Am J Psychiatry. 2013 Oct;170(10):1195-204. doi: 10.1176/appi.ajp.2013.12050651. PMID- 32419655 OWN - NLM STAT- MEDLINE DCOM- 20210813 LR - 20211203 IS - 1552-8456 (Electronic) IS - 0193-9459 (Print) IS - 0193-9459 (Linking) VI - 42 IP - 12 DP - 2020 Dec TI - Nurse Health: The Influence of Chronotype and Shift Timing. PG - 1031-1041 LID - 10.1177/0193945920916802 [doi] AB - Extreme chronotype and circadian disrupting work hours may increase nurse disease risks. This national, cross-sectional study of nurses (N = 527) had three hypotheses. When chronotype and shift times are incongruent, nurses will experience increased likelihood of (1) obesity, (2) cardiovascular disease/risk factors, and (3) obesity or cardiovascular disease/risk factors when theoretically linked variables exist. Chronotype mismatched nurses' (n = 206) average sleep (6.1 hours, SD = 1.2) fell below 7-9 hours/24-hours sleep recommendations. Proportion of male nurses was significantly higher chronotype mismatched (12.3%) than matched (6.3%). Analyses found no direct relationship between chronotype match/mismatch with outcome variables. Exploratory interaction analysis demonstrated nurses with mismatched chronotype and above average sleep quality had an estimated 3.51 times the adjusted odds (95% CI 1.52,8.17; p = .003) of being obese. Although mechanism is unclear, this suggests sleep quality may be intricately associated with obesity. Further research is needed to inform nurses on health risks from disrupted sleep, chronotypes, and shift work. FAU - Hittle, Beverly M AU - Hittle BM AUID- ORCID: 0000-0001-6327-3901 AD - College of Nursing, University of Cincinnati, Cincinnati, OH. FAU - Caruso, Claire C AU - Caruso CC AD - National Institute for Occupational Safety and Health, Division of Science Integration, Cincinnati, OH. FAU - Jones, Holly J AU - Jones HJ AD - College of Nursing, University of Cincinnati, Cincinnati, OH. FAU - Bhattacharya, Amit AU - Bhattacharya A AD - College of Medicine, University of Cincinnati, Cincinnati, OH. FAU - Lambert, Joshua AU - Lambert J AD - College of Nursing, University of Cincinnati, Cincinnati, OH. FAU - Gillespie, Gordon L AU - Gillespie GL AD - College of Nursing, University of Cincinnati, Cincinnati, OH. LA - eng GR - T42 OH008432/OH/NIOSH CDC HHS/United States GR - T42OH008432/ACL/ACL HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20200517 PL - United States TA - West J Nurs Res JT - Western journal of nursing research JID - 7905435 SB - IM MH - Adult MH - Cardiovascular Diseases/etiology MH - Circadian Rhythm/*physiology MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Nurses/*psychology MH - Obesity/etiology MH - Sleep/*physiology MH - Surveys and Questionnaires MH - Work Schedule Tolerance/*physiology PMC - PMC7659469 MID - NIHMS1643506 OTO - NOTNLM OT - cardiovascular disease OT - chronotype OT - healthcare workers OT - obesity OT - shift work OT - sleep COIS- Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2020/05/19 06:00 MHDA- 2021/08/14 06:00 PMCR- 2021/12/01 CRDT- 2020/05/19 06:00 PHST- 2020/05/19 06:00 [pubmed] PHST- 2021/08/14 06:00 [medline] PHST- 2020/05/19 06:00 [entrez] PHST- 2021/12/01 00:00 [pmc-release] AID - 10.1177/0193945920916802 [doi] PST - ppublish SO - West J Nurs Res. 2020 Dec;42(12):1031-1041. doi: 10.1177/0193945920916802. Epub 2020 May 17. PMID- 36121149 OWN - NLM STAT- MEDLINE DCOM- 20221111 LR - 20221216 IS - 1098-240X (Electronic) IS - 0160-6891 (Print) IS - 0160-6891 (Linking) VI - 45 IP - 6 DP - 2022 Dec TI - Temporal trends in health worker social media communication during the COVID-19 pandemic. PG - 636-651 LID - 10.1002/nur.22266 [doi] AB - During the COVID-19 pandemic, healthcare professionals are exposed to extreme hazards and workplace stressors. Social media postings by physicians and nurses related to COVID-19 from January 21 to June 1, 2020 were obtained from the Reddit website. Topic modeling via Latent Dirichlet Allocation (LDA) using a machine-learning approach was performed on 1723 documents, each posted in a unique Reddit discussion. We selected the optimal number of topics using a heuristic approach based on examination of the rate of perplexity change (RPC) across LDA models. A two-step multiple linear regression was done to identify differences across time and between nurses versus physicians. Prevalent topics included excessive workload, positive emotional expression and collegial support, anger and frustration, testing positive for COVID-19 and treatment, use of personal protective equipment, impacts on healthcare jobs, disruption of medical procedures, and general healthcare issues. Nurses' posts initially reflected concern about workload, personal danger, safety precautions, and emotional support to their colleagues. Physicians posted initially more often than nurses about technical aspects of the coronavirus disease, medical equipment, and treatment. Differences narrowed over time: nurses increasingly made technical posts, while physicians' posts increasingly were in the personal domain, suggesting a convergence of the professions over time. CI - © 2022 Wiley Periodicals LLC. FAU - Ford, Julian D AU - Ford JD AUID- ORCID: 0000-0001-7923-0658 AD - University of Connecticut School of Medicine, Farmington, Connecticut, USA. FAU - Marengo, Davide AU - Marengo D AUID- ORCID: 0000-0002-7107-0810 AD - Department of Psychology, University of Torino, Torino, Italy. FAU - Olff, Miranda AU - Olff M AUID- ORCID: 0000-0003-1016-9515 AD - Department of Psychology, University of Amsterdam, Amsterdam, Netherlands. FAU - Armour, Cherie AU - Armour C AUID- ORCID: 0000-0001-7649-3874 AD - Queens University Belfast, Belfast, UK. FAU - Elhai, Jon D AU - Elhai JD AUID- ORCID: 0000-0001-5205-9010 AD - Department of Psychology, University of Toledo, Toledo, Ohio, USA. FAU - Almquist, Zack AU - Almquist Z AUID- ORCID: 0000-0002-1967-123X AD - Department of Sociology, University of Washington, Seattle, Washington, USA. FAU - Spiro, Emma S AU - Spiro ES AUID- ORCID: 0000-0002-6792-3390 AD - Department of Sociology, University of Washington, Seattle, Washington, USA. LA - eng PT - Journal Article DEP - 20220919 PL - United States TA - Res Nurs Health JT - Research in nursing & health JID - 7806136 SB - IM MH - Humans MH - *COVID-19 MH - *Social Media MH - Pandemics MH - SARS-CoV-2 MH - *Health Communication PMC - PMC9538053 OTO - NOTNLM OT - COVID-19 OT - nurses OT - physicians OT - social media OT - temporal trends COIS- The authors declare no conflict of interest. EDAT- 2022/09/20 06:00 MHDA- 2022/11/15 06:00 PMCR- 2022/09/19 CRDT- 2022/09/19 07:53 PHST- 2022/08/24 00:00 [revised] PHST- 2022/05/16 00:00 [received] PHST- 2022/08/25 00:00 [accepted] PHST- 2022/09/20 06:00 [pubmed] PHST- 2022/11/15 06:00 [medline] PHST- 2022/09/19 07:53 [entrez] PHST- 2022/09/19 00:00 [pmc-release] AID - NUR22266 [pii] AID - 10.1002/nur.22266 [doi] PST - ppublish SO - Res Nurs Health. 2022 Dec;45(6):636-651. doi: 10.1002/nur.22266. Epub 2022 Sep 19. PMID- 37878925 OWN - NLM STAT- MEDLINE DCOM- 20231027 LR - 20231027 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 28 IP - 10 DP - 2023 Oct TI - Work conditions and biosafety of health professionals and invisible health workers in the context of COVID-19 in Brazil. PG - 2809-2822 LID - S1413-81232023001002809 [pii] LID - 10.1590/1413-812320232810.10072023 [doi] AB - The present article addresses the work conditions in health in the context of the COVID-19 pandemic in Brazil. This is a cross-sectional study that used data from the surveys "Working conditions of healthcare professionals in the context of Covid-19 in Brazil" and "Invisible healthcare workers: work conditions and mental health in the context of Covid-19 in Brazil", seeking to better understand the working conditions and biosafety of these two distinct and socially unequal professional contingents. Data analysis proves that work conditions were extremely affected due to inadequate infrastructures, strenuous work, biosecurity at risk, exhaustion, fear of contamination and death, strong signs of physical and mental exhaustion, among workers. It also points out the discrimination and inequalities of social rights and professional development that mark the worlds of work highlighted in the surveys, emphasizing the profound inequalities that exist in Brazil and in its regions. It concludes by showing the importance of formulating public policies within the scope of work management in SUS, which ensures the protection, appreciation and reduction of inequalities pointed out in this article. FAU - Machado, Maria Helena AU - Machado MH AUID- ORCID: 0000-0002-5209-2424 AD - Centro de Estudos Estratégicos (CEE), Escola Nacional de Saúde Pública (ENSP), Fundação Oswaldo Cruz (Fiocruz). R. Leopoldo Bulhões 1480, Manguinhos. 21041-210 Rio de Janeiro RJ Brasil. helenamachado06@gmail.com. FAU - Coelho, Maria Carlota de Rezende AU - Coelho MCR AUID- ORCID: 0000-0002-4556-5107 AD - Hospital Universitário da Universidade Federal do Espírito Santo (UFES). Vitória ES Brasil. FAU - Pereira, Everson Justino AU - Pereira EJ AUID- ORCID: 0000-0002-4389-306X AD - Núcleo de Estudos e Pesquisas em Recursos Humanos em Saúde (NERHUS), ENSP, Fiocruz. Rio de Janeiro RJ Brasil. FAU - Telles, Alexandre Oliveira AU - Telles AO AUID- ORCID: 0000-0001-6351-5966 AD - Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ). Rio de Janeiro RJ Brasil. FAU - Soares Neto, Joaquim José AU - Soares Neto JJ AUID- ORCID: 0000-0001-6319-1041 AD - Universidade de Brasília (UnB). Brasília DF Brasil. FAU - Ximenes Neto, Francisco Rosemiro Guimarães AU - Ximenes Neto FRG AUID- ORCID: 0000-0002-7905-9990 AD - Curso de Enfermagem, Universidade Estadual Vale do Acaraú (UVA). Sobral CE Brasil. FAU - Guimarães-Teixeira, Eleny AU - Guimarães-Teixeira E AUID- ORCID: 0000-0003-0477-3062 AD - Departamento de Clínica Médica, Escola de Medicina, Fundação Técnico Educacional Souza Marques (FTESM). Rio de Janeiro RJ Brasil. FAU - Bembele, João Niquice AU - Bembele JN AUID- ORCID: 0000-0002-0533-8321 AD - Departamento de Formação e Pesquisa, Direcção Provincial de Saúde de Maputo. Maputo Moçambique. FAU - Silva, Luciana Guedes da AU - Silva LGD AUID- ORCID: 0000-0002-5909-3462 AD - Universidade de Brasília (UnB). Brasília DF Brasil. FAU - Vargas, Filipe Leonel AU - Vargas FL AUID- ORCID: 0000-0002-7698-9260 AD - Coordenação de Comunicação Institucional (CCI), ENSP, Fiocruz. Rio de Janeiro RJ Brasil. LA - por LA - eng PT - Journal Article TT - Condições de trabalho e biossegurança dos profissionais de saúde e trabalhadores invisíveis da saúde no contexto da COVID-19 no Brasil. DEP - 20230628 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Humans MH - *COVID-19 MH - SARS-CoV-2 MH - Pandemics MH - Brazil/epidemiology MH - Containment of Biohazards MH - Cross-Sectional Studies MH - Health Personnel/psychology EDAT- 2023/10/25 18:42 MHDA- 2023/10/27 06:42 CRDT- 2023/10/25 15:24 PHST- 2022/10/20 00:00 [received] PHST- 2023/06/01 00:00 [accepted] PHST- 2023/10/27 06:42 [medline] PHST- 2023/10/25 18:42 [pubmed] PHST- 2023/10/25 15:24 [entrez] AID - S1413-81232023001002809 [pii] AID - 10.1590/1413-812320232810.10072023 [doi] PST - ppublish SO - Cien Saude Colet. 2023 Oct;28(10):2809-2822. doi: 10.1590/1413-812320232810.10072023. Epub 2023 Jun 28. PMID- 33711939 OWN - NLM STAT- MEDLINE DCOM- 20210405 LR - 20210405 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 21 IP - 1 DP - 2021 Mar 12 TI - A spatiotemporal simulation study on the transmission of harmful microorganisms through connected healthcare workers in a hospital ward setting. PG - 260 LID - 10.1186/s12879-021-05954-7 [doi] LID - 260 AB - BACKGROUND: Hand transmission of harmful microorganisms may lead to infections and poses a major threat to patients and healthcare workers in healthcare settings. The most effective countermeasure against these transmissions is the adherence to spatiotemporal hand hygiene policies, but adherence rates are relatively low and vary over space and time. The spatiotemporal effects on hand transmission and spread of these microorganisms for varying hand hygiene compliance levels are unknown. This study aims to (1) identify a healthcare worker occupancy group of potential super-spreaders and (2) quantify spatiotemporal effects on the hand transmission and spread of harmful microorganisms for varying levels of hand hygiene compliance caused by this group. METHODS: Spatiotemporal data were collected in a hospital ward of an academic hospital using radio frequency identification technology for 7 days. A potential super-spreader healthcare worker occupation group was identified using the frequency identification sensors' contact data. The effects of five probability distributions of hand hygiene compliance and three harmful microorganism transmission rates were simulated using a dynamic agent-based simulation model. The effects of initial simulation assumptions on the simulation results were quantified using five risk outcomes. RESULTS: Nurses, doctors and patients are together responsible for 81.13% of all contacts. Nurses made up 70.68% of all contacts, which is more than five times that of doctors (10.44%). This identifies nurses as the potential super-spreader healthcare worker occupation group. For initial simulation conditions of extreme lack of hand hygiene compliance (5%) and high transmission rates (5% per contact moment), a colonised nurse can transfer microbes to three of the 17 healthcare worker or patients encountered during the 98.4 min of visiting 23 rooms while colonised. The harmful microorganism transmission potential for nurses is higher during weeknights (5 pm - 7 am) and weekends as compared to weekdays (7 am - 5 pm). CONCLUSION: Spatiotemporal behaviour and social mixing patterns of healthcare can change the expected number of hand transmissions and spread of harmful microorganisms by super-spreaders in a closed healthcare setting. These insights can be used to evaluate spatiotemporal safety behaviours and develop infection prevention and control strategies. FAU - van Niekerk, J M AU - van Niekerk JM AD - Department of Psychology, Health and Technology/Center for eHealth Research and Disease Management, Faculty of Behavioural Sciences, University of Twente, Enschede, The Netherlands. j.m.vanniekerk@utwente.nl. AD - Department of Earth Observation Sciences, Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, The Netherlands. j.m.vanniekerk@utwente.nl. AD - Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. j.m.vanniekerk@utwente.nl. FAU - Stein, A AU - Stein A AD - Department of Earth Observation Sciences, Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, The Netherlands. FAU - Doting, M H E AU - Doting MHE AD - Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Lokate, M AU - Lokate M AD - Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. FAU - Braakman-Jansen, L M A AU - Braakman-Jansen LMA AD - Department of Psychology, Health and Technology/Center for eHealth Research and Disease Management, Faculty of Behavioural Sciences, University of Twente, Enschede, The Netherlands. FAU - van Gemert-Pijnen, J E W C AU - van Gemert-Pijnen JEWC AD - Department of Psychology, Health and Technology/Center for eHealth Research and Disease Management, Faculty of Behavioural Sciences, University of Twente, Enschede, The Netherlands. AD - Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. LA - eng GR - 122084/Interreg/ GR - 202085/Interreg/ PT - Journal Article DEP - 20210312 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - *Computer Simulation MH - Cross Infection/prevention & control/*transmission MH - Hand Hygiene MH - *Health Personnel MH - Hospitals MH - Humans MH - Nurses MH - Radio Frequency Identification Device MH - Risk MH - *Spatio-Temporal Analysis PMC - PMC7953685 OTO - NOTNLM OT - Hand hygiene compliance OT - Healthcare-associated infections OT - RFID OT - Spatiotemporal risk OT - Spatiotemporal simulation OT - Transmission OT - Wearable proximity sensors COIS- None. EDAT- 2021/03/14 06:00 MHDA- 2021/04/07 06:00 PMCR- 2021/03/12 CRDT- 2021/03/13 05:26 PHST- 2020/04/21 00:00 [received] PHST- 2021/03/03 00:00 [accepted] PHST- 2021/03/13 05:26 [entrez] PHST- 2021/03/14 06:00 [pubmed] PHST- 2021/04/07 06:00 [medline] PHST- 2021/03/12 00:00 [pmc-release] AID - 10.1186/s12879-021-05954-7 [pii] AID - 5954 [pii] AID - 10.1186/s12879-021-05954-7 [doi] PST - epublish SO - BMC Infect Dis. 2021 Mar 12;21(1):260. doi: 10.1186/s12879-021-05954-7. PMID- 35582179 OWN - NLM STAT- MEDLINE DCOM- 20220519 LR - 20230109 IS - 2641-7650 (Electronic) IS - 2641-7650 (Linking) VI - 3 IP - 3 DP - 2022 Mar 31 TI - Patient-Reported Experiences after Acute Kidney Injury across Multiple Health-Related Quality-of-Life Domains. PG - 426-434 LID - 10.34067/KID.0002782021 [doi] AB - BACKGROUND: Investigations of health-related quality of life (HRQoL) in AKI have been limited in number, size, and domains assessed. We surveyed AKI survivors to describe the range of HRQoL AKI-related experiences and examined potential differences in AKI effects by sex and age at AKI episode. METHODS: AKI survivors among American Association of Kidney Patients completed an anonymous online survey in September 2020. We assessed: (1) sociodemographic characteristics; (2) effects of AKI-physical, emotional, social; and (3) perceptions about interactions with health care providers using quantitative and qualitative items. RESULTS: Respondents were 124 adult AKI survivors. Eighty-four percent reported that the AKI episode was very/extremely impactful on physical/emotional health. Fifty-seven percent reported being very/extremely concerned about AKI effects on work, and 67% were concerned about AKI effects on family. Only 52% of respondents rated medical team communication as very/extremely good. Individuals aged 22-65 years at AKI episode were more likely than younger/older counterparts to rate the AKI episode as highly impactful overall (90% versus 63% younger and 75% older individuals; P=0.04), more impactful on family (78% versus 50% and 46%; P=0.008), and more impactful on work (74% versus 38% and 10%; P<0.001). Limitations of this work include convenience sampling, retrospective data collection, and unknown AKI severity. CONCLUSIONS: These findings are a critical step forward in understanding the range of AKI experiences/consequences. Future research should incorporate more comprehensive HRQoL measures, and health care professionals should consider providing more information in their patient communication about AKI and follow-up. CI - Copyright © 2022 by the American Society of Nephrology. FAU - Switzer, Galen E AU - Switzer GE AUID- ORCID: 0000-0001-8541-9449 AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. FAU - Puttarajappa, Chethan M AU - Puttarajappa CM AUID- ORCID: 0000-0002-4856-9242 AD - Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Kane-Gill, Sandra L AU - Kane-Gill SL AUID- ORCID: 0000-0001-7523-4846 AD - Department of Pharmacy, University of Pittsburgh Medical Center, School of Pharmacy, University of Pittsburgh, Pennsylvania. FAU - Fried, Linda F AU - Fried LF AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Center for Health Equity Research and Promotion, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. AD - Department of Epidemiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania. AD - Kidney Medicine Section Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania. FAU - Abebe, Kaleab Z AU - Abebe KZ AUID- ORCID: 0000-0002-3644-8419 AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Center for Research on Health Care Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Kellum, John A AU - Kellum JA AD - Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Jhamb, Manisha AU - Jhamb M AUID- ORCID: 0000-0002-9178-1468 AD - Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Bruce, Jessica G AU - Bruce JG AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Kuniyil, Vidya AU - Kuniyil V AUID- ORCID: 0000-0003-3996-8177 AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Conway, Paul T AU - Conway PT AUID- ORCID: 0000-0002-3344-6936 AD - Chair of Policy and Global Affairs and Immediate Past President of American Association of Kidney Patients. FAU - Knight, Richard AU - Knight R AUID- ORCID: 0000-0002-7429-4190 AD - Current President of American Association of Kidney Patients. FAU - Murphy, John AU - Murphy J AD - McGowan Institute for Regenerative Medicine, and Chemical Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Palevsky, Paul M AU - Palevsky PM AUID- ORCID: 0000-0002-7334-5400 AD - Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Kidney Medicine Section Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania. AD - Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. AD - Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. LA - eng PT - Journal Article DEP - 20211208 PL - United States TA - Kidney360 JT - Kidney360 JID - 101766381 SB - IM MH - Acute Kidney Injury/epidemiology/*psychology MH - Adult MH - Age Factors MH - Aged MH - Health Impact Assessment MH - Humans MH - Middle Aged MH - *Patient Reported Outcome Measures MH - *Quality of Life/psychology MH - Retrospective Studies MH - Sex Factors MH - Survivors/*psychology MH - United States/epidemiology MH - Young Adult PMC - PMC9034810 OTO - NOTNLM OT - Patient Reported Outcome Measures OT - acute kidney injury OT - acute kidney injury and ICU nephrology OT - kidney disease OT - quality of life COIS- P. Conway reports the following: Current Employer: Conway Strategies Global; Honoraria: 2018–2021: University of California Irvine; Arizona Advice Collaborative/Arizona Department of Health; Kidney Research Institute & Center for Dialysis Innovation, University of Washington; Bayer; Novartis, Global Transplant Patient Reported Outcome Measure Patient Advisory Committee; Scientific Advisor or Membership: Chair Policy/Global Affairs, Past President, American Association of Kidney Patients; Chair, Patient Engagement Advisory Committee, Food and Drug Administration; Congressionally Directed Medical Research Program, Department of Defense; Patient Voice Editor, Clinical Journal of the American Society of Nephrology; Kidney Health Initiative; Nephrology Specialty Board, American Board of Internal Medicine; External Expert Panel, Kidney Precision Medicine Project, National Institutes of Health; and Other Interests/Relationships: Contract Management Board, Renal Data System; Co-Chair, AAKP/George Washington University School of Medicine & Health Sciences Global Summit on Kidney Disease Innovations; Participant Advisory Board, University of Pittsburgh/NIH Acute Kidney Injury Study; World Health Organization Lived Experience Advocacy Research; Centers for Disease Control, Health Infections Control Practices Advisory Committee; FDA Cardiovascular Devices Advisory Committee; FDA Medical Devices Advisory Committee. L.F. Fried reports consultancy agreements with Bayer and is on the data safety monitoring boards for CSL Behring and Novonordisk. M. Jhamb reports research funding from the Arbor Research Collaborative for Health, Bayer LLC, Dialysis Clinic, Inc., and NIH, and is a member of the ASN and the National Kidney Foundation. S.L. Kane-Gill reports research funding from the National Institute of Diabetes and Digestive and Kidney Diseases. J.A. Kellum reports consultancy agreements with AM Pharma, Astellas, Astute Medical, Baxter, bioMerieux, Cytosorbents, Grifols, Klotho, Mallinckrodt, NxStage, PhotoPhage, Potrero, and RenalSense; ownership interest in J3RM, Klotho, Photophage, and Spectral Medical; research funding from Astute Medical, Astellas, Atox Bio, Baxter, bioMerieux, Bioporto, Cytosorbents, Grifols, and RenalSense; has patents and inventions with Astute Medical, Cytosorbents, J3RM, Klotho, and Photophage; is editor of Critical Care Clinics of North America and on the editorial boards of Blood Purification, Critical Care, Critical Care Medicine, and Nephrology Dialysis Transplantation. R. Knight reports honoraria from American Kidney Fund, Johns Hopkins Center for Health Equity, Labcorp, Northwestern University, Novartis, Otsuka, Personalized Medicine Coalition; is a member of the NIDDK Advisory Council and SRTR Visiting Committee; is on the scientific advisory board for the “Rescuing Kidneys at Risk of Discard” project; participates in a speakers’ bureau for AAKP; is President of the AAKP; is a member of the Quality Insights Patient Advisory Committee; and is a member of the NRAA/ESRD Forum Health Information Technology Project, NIDDK—Health Information Technology Workgroup, Bowie State University Board of Advisors, and SRTR Visiting Committee. P.M. Palevsky reports consultancy agreements with Janssen Research and Development, LLC; is President, a member, and on the Scientific Advisory Board of the National Kidney Foundation; is a member and on the Quality, Safety and Accountability Committee of the Renal Physicians Association; is chair and on the Medical Review Board of Quality Insights Renal Network 4; is Section Editor, Renal Failure, for UpToDate; and is a member and on the Editorial Board of the Journal of Intensive Care Medicine. The remaining authors have nothing to disclose. EDAT- 2022/05/19 06:00 MHDA- 2022/05/20 06:00 PMCR- 2021/12/08 CRDT- 2022/05/18 02:06 PHST- 2021/04/23 00:00 [received] PHST- 2021/11/29 00:00 [accepted] PHST- 2022/05/18 02:06 [entrez] PHST- 2022/05/19 06:00 [pubmed] PHST- 2022/05/20 06:00 [medline] PHST- 2021/12/08 00:00 [pmc-release] AID - 02200512-202203000-00007 [pii] AID - K3602021000278 [pii] AID - 10.34067/KID.0002782021 [doi] PST - epublish SO - Kidney360. 2021 Dec 8;3(3):426-434. doi: 10.34067/KID.0002782021. eCollection 2022 Mar 31. PMID- 32854203 OWN - NLM STAT- MEDLINE DCOM- 20201123 LR - 20201123 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 17 IP - 17 DP - 2020 Aug 25 TI - A Comprehensive Model for Estimating Heat Vulnerability of Young Athletes. LID - 10.3390/ijerph17176156 [doi] LID - 6156 AB - Current methods for estimating heat vulnerability of young athletes use a heat index (HI) or a wet bulb globe thermometer (WBGT), neither of which fully include the environmental or physiological characteristics that can affect a person's heat budget, particularly where activity occurs on a synthetic surface. This study analyzed and compared the standard methods, HI and WBGT, with a novel and more comprehensive method termed COMFA-Kid (CK) which is based on an energy budget model explicitly designed for youth. The COMFA model was presented at the same time to demonstrate the difference between a child and an adult during activity. Micrometeorological measurements were taken at a synthetic-surfaced football field during mid-day in hot environmental conditions. Standard methods (HI and WBGT) indicated that conditions on the field were relatively safe for youth to engage in activities related to football practice or games, whereas the CK method indicated that conditions were dangerously hot and could lead to exertional heat illness. Estimates using the CK method also indicated that coaches and staff standing on the sidelines, and parents sitting in the stands, would not only be safe from heat but would be thermally comfortable. The difference in thermal comfort experienced by coaches and staff off the field, versus that experienced by young players on the field, could affect decision making regarding the duration and intensity of practices and time in the game. The CK method, which is easy to use and available for modification for specific conditions, would lead to more accurate estimates of heat safety on outdoor synthetic surfaces in particular, and in sports with a high prevalence of heat illness such as football, and should be considered as a complementary or alternative preventive measure against heat. FAU - Cheng, Wenwen AU - Cheng W AUID- ORCID: 0000-0003-1160-0928 AD - College of Architecture, The University of Oklahoma, Norman, OK 73019, USA. FAU - Spengler, J O AU - Spengler JO AD - School of Public Health, Texas A&M University, College Station, TX 77843, USA. FAU - Brown, Robert D AU - Brown RD AUID- ORCID: 0000-0001-6955-910X AD - Department of Landscape Architecture and Urban Planning, Texas A&M University, College Station, TX 77843, USA. LA - eng PT - Journal Article DEP - 20200825 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Adult MH - Athletes/*psychology/statistics & numerical data MH - Child MH - Extreme Heat MH - *Football MH - Heat Stress Disorders/*prevention & control MH - Hot Temperature MH - Humans MH - *Soccer PMC - PMC7503897 OTO - NOTNLM OT - WBGT OT - ballfield design OT - energy budget thermal model OT - heat stress index OT - young athletes thermal health COIS- The authors declare no conflict of interest. EDAT- 2020/08/29 06:00 MHDA- 2020/11/24 06:00 PMCR- 2020/09/01 CRDT- 2020/08/29 06:00 PHST- 2020/06/24 00:00 [received] PHST- 2020/08/12 00:00 [revised] PHST- 2020/08/20 00:00 [accepted] PHST- 2020/08/29 06:00 [entrez] PHST- 2020/08/29 06:00 [pubmed] PHST- 2020/11/24 06:00 [medline] PHST- 2020/09/01 00:00 [pmc-release] AID - ijerph17176156 [pii] AID - ijerph-17-06156 [pii] AID - 10.3390/ijerph17176156 [doi] PST - epublish SO - Int J Environ Res Public Health. 2020 Aug 25;17(17):6156. doi: 10.3390/ijerph17176156. PMID- 32388722 OWN - NLM STAT- MEDLINE DCOM- 20200731 LR - 20220216 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 179 IP - 8 DP - 2020 Aug TI - To mask or not to mask children to overcome COVID-19. PG - 1267-1270 LID - 10.1007/s00431-020-03674-9 [doi] AB - It has been reported that asymptomatic people can transmit the new coronavirus disease 2019 (COVID-19) and become important sources of COVID-19. To reduce the role of asymptomatic or poorly symptomatic people in COVID-19, universal use of face masks in addition to hand hygiene and safety distance seems extremely useful. Consequently, preparing the healthy child to use face masks is strongly needed. To obtain maximal compliance, reasons for mask wearing without attempts of removing must be clearly explained. Moreover, child's will must not be forced.Conclusion: On the basis of clinical findings, we think that the universal use of facial masks seems necessary when people have to go out in their everyday lives. In addition to the availability of masks of different sizes capable of adapting perfectly to the face, it is necessary that the use of masks in children is preceded by a strong parental work and school lessons on this issue and other hygiene topics with the main aim to obtain child cooperation. What is Known: • Asymptomatic people can transmit and become important sources of COVID-19. • Asymptomatic cases are common also in pediatrics. What is New: • Universal use of face masks for success against COVID-19 seems necessary also in pediatric age when people have to go out in their everyday lives. • In addition to the availability of masks of different sizes capable of adapting perfectly to the face, it is necessary that the use of masks in children is preceded by a strong parental work and school lessons with the main aim to obtain child cooperation. FAU - Esposito, Susanna AU - Esposito S AUID- ORCID: 0000-0003-4103-2837 AD - Pediatric Clinic, Pietro Barilla Children's Hospital, Via Gramsci 14, 43126, Parma, Italy. susannamariaroberta.esposito@unipr.it. AD - Department of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126, Parma, Italy. susannamariaroberta.esposito@unipr.it. FAU - Principi, Nicola AU - Principi N AD - Università degli Studi di Milano, Milan, Italy. LA - eng PT - Journal Article DEP - 20200509 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM CIN - Eur J Pediatr. 2020 Aug;179(8):1339-1340. doi: 10.1007/s00431-020-03720-6. PMID: 32564146 CIN - Eur J Pediatr. 2020 Aug;179(8):1341-1342. doi: 10.1007/s00431-020-03725-1. PMID: 32607621 MH - *Betacoronavirus MH - COVID-19 MH - Child MH - Child Behavior/*psychology MH - *Child Health MH - *Child Welfare MH - Coronavirus Infections/*prevention & control/psychology/transmission MH - Humans MH - *Masks MH - Pandemics/*prevention & control MH - Parenting MH - Pneumonia, Viral/*prevention & control/psychology/transmission MH - Psychology, Child MH - SARS-CoV-2 PMC - PMC7210459 OTO - NOTNLM OT - COVID-19 OT - Face mask OT - SARS-CoV-2 OT - Surgical mask COIS- The authors declare that they have no conflict of interest. EDAT- 2020/05/11 06:00 MHDA- 2020/08/01 06:00 PMCR- 2020/05/09 CRDT- 2020/05/11 06:00 PHST- 2020/04/18 00:00 [received] PHST- 2020/04/29 00:00 [accepted] PHST- 2020/04/26 00:00 [revised] PHST- 2020/05/11 06:00 [pubmed] PHST- 2020/08/01 06:00 [medline] PHST- 2020/05/11 06:00 [entrez] PHST- 2020/05/09 00:00 [pmc-release] AID - 10.1007/s00431-020-03674-9 [pii] AID - 3674 [pii] AID - 10.1007/s00431-020-03674-9 [doi] PST - ppublish SO - Eur J Pediatr. 2020 Aug;179(8):1267-1270. doi: 10.1007/s00431-020-03674-9. Epub 2020 May 9. PMID- 22624283 OWN - NLM STAT- MEDLINE DCOM- 20120611 LR - 20220330 IS - 0004-5772 (Print) IS - 0004-5772 (Linking) VI - 59 Suppl DP - 2011 Dec TI - Cardiac rehabilitation after myocardial infarction. PG - 51-5 AB - Cardiac rehabilitation/secondary prevention programs are recognized as integral to the comprehensive care of patients with coronary heart disease (CHD), and as such are recommended as useful and effective (Class I) by the American Heart Association and the American College of Cardiology in the treatment of patients with CHD. The term cardiac rehabilitation refers to coordinated, multifaceted interventions designed to optimize a cardiac patient's physical, psychological, and social functioning, in addition to stabilizing, slowing, or even reversing the progression of the underlying atherosclerotic processes, thereby reducing morbidity and mortality. Cardiac rehabilitation, aims at returning the patient back to normal functioning in a safe and effective manner and to enhance the psychosocial and vocational state of the patient. The program involves education, exercise, risk factor modification and counselling. A meta-analysis based on a review of 48 randomized trials that compared outcomes of exercise-based rehabilitation with usual medical care, showed a reduction of 20% in total mortality and 26% in cardiac mortality rates, with exercise-based rehabilitation compared with usual medical care. Risk stratification helps identify patients who are at increased risk for exercise-related cardiovascular events and who may require more intensive cardiac monitoring in addition to the medical supervision provided for all cardiac rehabilitation program participants. During exercise, the patients' ECG is continuously monitored through telemetry, which serves to optimize the exercise prescription and enhance safety. The safety of cardiac rehabilitation exercise programs is well established, and the occurrence of major cardiovascular events during supervised exercise is extremely low. As hospital stays decrease, cardiac rehabilitation is assuming an increasingly important role in secondary prevention. In contrast with its growing importance internationally, there are very few cardiac rehabilitation centers in India at the present moment. FAU - Contractor, Aashish S AU - Contractor AS AD - Department Preventive Cardiology & Cardiac Rehabilitation, Asian Heart Institute, Bandra-Kurla Complex, Bandra (E), Mumbai-400051. LA - eng PT - Journal Article PL - India TA - J Assoc Physicians India JT - The Journal of the Association of Physicians of India JID - 7505585 SB - IM MH - Adaptation, Psychological MH - *Comprehensive Health Care MH - *Exercise Therapy MH - Guidelines as Topic MH - Humans MH - India MH - Myocardial Infarction/*psychology/*rehabilitation MH - Recovery of Function MH - Risk Factors MH - Risk Reduction Behavior MH - Secondary Prevention/*methods MH - Social Support EDAT- 2012/05/26 06:00 MHDA- 2012/06/12 06:00 CRDT- 2012/05/26 06:00 PHST- 2012/05/26 06:00 [entrez] PHST- 2012/05/26 06:00 [pubmed] PHST- 2012/06/12 06:00 [medline] PST - ppublish SO - J Assoc Physicians India. 2011 Dec;59 Suppl:51-5. PMID- 25253521 OWN - NLM STAT- MEDLINE DCOM- 20150522 LR - 20220408 IS - 1882-6482 (Electronic) IS - 0021-5082 (Linking) VI - 69 IP - 3 DP - 2014 TI - [Mental health survey of truck drivers]. PG - 199-204 AB - OBJECTIVES: The health management of truck drivers has long been considered extremely important from the perspective of prevention of diseases and traffic accidents. Today, truck drivers may have various underlying health problems, including psychological burden caused by deregulation with the enforcement of the Trucking Business Act, rising fuel costs, and even economic stagnation. In this study, we investigated the mental health of individuals working in transportation and logistics sectors, which ensures the secure supply and sound development of safe and high-quality transportation services. METHODS: To ascertain the mental health status in this population, we used the General Health Questionnaire (GHQ30), an assessment of mental health and currently the general health questionnaire most widely used by the department of psychosomatic medicine and other clinical departments. RESULTS: Although the mean GHQ30 score of all the subjects in this study was below the cutoff point of 6-7, which separates individuals with mental health problems from those who without 30% of the subjects were classified as having mental health problems, revealing the need for routine screening of the mental health status and severity of symptoms of truck drivers. CONCLUSIONS: There is growing recognition of the importance of establishing mental healthcare services in the workplace because of the sharply increasing number of applications for workers' compensation due to suicides from overwork. In this study, 16.7% of truck drivers expressed suicidal thoughts, indicating that it is necessary to conduct follow-up surveys of the mental conditions of truck drivers in order to put in place appropriate mental health measures. FAU - Kaneko, Shin-ya AU - Kaneko SY AD - Kansai University Faculty of Safety Science. LA - jpn PT - Journal Article PL - Japan TA - Nihon Eiseigaku Zasshi JT - Nihon eiseigaku zasshi. Japanese journal of hygiene JID - 0417457 SB - IM MH - Adult MH - Aged MH - Automobile Driving/*psychology MH - Female MH - Health Surveys/statistics & numerical data MH - Humans MH - Japan MH - Male MH - Mental Health/*statistics & numerical data MH - Middle Aged MH - *Motor Vehicles MH - Occupational Health/*statistics & numerical data MH - *Stress, Psychological MH - Workplace/psychology EDAT- 2014/09/26 06:00 MHDA- 2015/05/23 06:00 CRDT- 2014/09/26 06:00 PHST- 2014/09/26 06:00 [entrez] PHST- 2014/09/26 06:00 [pubmed] PHST- 2015/05/23 06:00 [medline] AID - DN/JST.JSTAGE/jjh/69.199 [pii] AID - 10.1265/jjh.69.199 [doi] PST - ppublish SO - Nihon Eiseigaku Zasshi. 2014;69(3):199-204. doi: 10.1265/jjh.69.199. PMID- 35998957 OWN - NLM STAT- MEDLINE DCOM- 20220825 LR - 20240903 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 12 IP - 8 DP - 2022 Aug 23 TI - Relationship between working conditions and psychological distress experienced by junior doctors in the UK during the COVID-19 pandemic: a cross-sectional survey study. PG - e061331 LID - 10.1136/bmjopen-2022-061331 [doi] LID - e061331 AB - OBJECTIVES: This paper explored the self-reported prevalence of depression, anxiety and stress among junior doctors during the COVID-19 pandemic. It also reports the association between working conditions and psychological distress experienced by junior doctors. DESIGN: A cross-sectional online survey study was conducted, using the 21-item Depression, Anxiety and Stress Scale and Health and Safety Executive scale to measure psychological well-being and working cultures of junior doctors. SETTING: The National Health Service in the UK. PARTICIPANTS: A sample of 456 UK junior doctors was recruited online during the COVID-19 pandemic from March 2020 to January 2021. RESULTS: Junior doctors reported poor mental health, with over 40% scoring extremely severely depressed (45.2%), anxious (63.2%) and stressed (40.2%). Both gender and ethnicity were found to have a significant influence on levels of anxiety. Hierarchical multiple linear regression analysis outlined the specific working conditions which significantly predicted depression (increased demands (β=0.101), relationships (β=0.27), unsupportive manager (β=-0.111)), anxiety (relationships (β=0.31), change (β=0.18), demands (β=0.179)) and stress (relationships (β=0.18), demands (β=0.28), role (β=0.11)). CONCLUSIONS: The findings illustrate the importance of working conditions for junior doctors' mental health, as they were significant predictors for depression, anxiety and stress. Therefore, if the mental health of junior doctors is to be improved, it is important that changes or interventions specifically target the working environment rather than factors within the individual clinician. CI - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. FAU - Dunning, Alice AU - Dunning A AUID- ORCID: 0000-0001-5078-7567 AD - Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK alice.dunning@bthft.nhs.uk. FAU - Teoh, Kevin AU - Teoh K AUID- ORCID: 0000-0002-6490-8208 AD - Department of Organizational Psychology, Birkbeck University of London, London, UK. FAU - Martin, James AU - Martin J AD - Institute of Applied Health Research, University of Birmingham, Birmingham, UK. FAU - Spiers, Johanna AU - Spiers J AUID- ORCID: 0000-0002-3935-1997 AD - College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. FAU - Buszewicz, Marta AU - Buszewicz M AD - Research Department of Primary Care and Population Health, University College London, London, UK. FAU - Chew-Graham, Carolyn AU - Chew-Graham C AUID- ORCID: 0000-0002-9722-9981 AD - School of Medicine, Keele University, Keele, UK. FAU - Taylor, Anna Kathryn AU - Taylor AK AUID- ORCID: 0000-0002-8149-3841 AD - School of Medicine, University of Leeds, Leeds, UK. FAU - Gopfert, Anya AU - Gopfert A AD - School of Medicine, Oxford University Hospitals NHS Trust, Oxford, UK. FAU - Van Hove, Maria AU - Van Hove M AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Appleby, Louis AU - Appleby L AD - Department of Psychiatry & Behavioral Sciences, The University of Manchester Faculty of Medical and Human Sciences, Manchester, UK. FAU - Riley, Ruth AU - Riley R AUID- ORCID: 0000-0001-8774-5344 AD - School of Health Sciences, University of Surrey, Guildford, UK. LA - eng GR - DH_/Department of Health/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220823 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - *COVID-19/epidemiology MH - Cross-Sectional Studies MH - Depression/epidemiology/psychology MH - Humans MH - Pandemics MH - *Psychological Distress MH - State Medicine MH - United Kingdom/epidemiology PMC - PMC9402444 OTO - NOTNLM OT - COVID-19 OT - education & training (see medical education & training) OT - health & safety OT - human resource management OT - organisational development OT - quality in health care COIS- Competing interests: None declared. EDAT- 2022/08/24 06:00 MHDA- 2022/08/26 06:00 PMCR- 2022/08/23 CRDT- 2022/08/23 20:52 PHST- 2022/08/23 20:52 [entrez] PHST- 2022/08/24 06:00 [pubmed] PHST- 2022/08/26 06:00 [medline] PHST- 2022/08/23 00:00 [pmc-release] AID - bmjopen-2022-061331 [pii] AID - 10.1136/bmjopen-2022-061331 [doi] PST - epublish SO - BMJ Open. 2022 Aug 23;12(8):e061331. doi: 10.1136/bmjopen-2022-061331. PMID- 39430703 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241106 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 10 DP - 2024 Jan-Dec TI - Feasibility and acceptability of wearable devices and daily diaries to assess sleep and other health indicators among young women in the slums of Kampala, Uganda. PG - 20552076241288754 LID - 10.1177/20552076241288754 [doi] LID - 20552076241288754 AB - BACKGROUND: Individuals in Uganda's urban slums have unmet mental health needs due to limited healthcare infrastructure, poor environmental conditions, and extreme poverty. Researchers often use wearable devices to measure factors associated with mental health including sleep, physical activity, and exposure to environmental stressors. However, the use of wearables for research purposes in low-resource settings is limited. This pilot study investigated the feasibility and acceptability of wearables and accompanying daily diaries to assess sleep and other health indicators in young women living in Kampala's slums. METHODS: Women (n = 60 total, two groups) aged 18-24 living in three urban slums participated in 5-day pilot protocols comprised of wearing Garmin vívoactive 3 smartwatches and completing daily diaries concerning sleep and physical activities. Participants completed surveys about their experiences. We based analyses on survey findings and data completeness. RESULTS: All participants responded to daily diaries. All but one reported wearing the device nonstop and 51 had recoverable heart rate data with median data coverage of 93.2%. Most devices (87.5%) recorded data for 5 days without running out of battery. Some participants (8.5%) found the wearable uncomfortable during the day, and 25% found it uncomfortable at night. Few participants (6.7%) reported feeling unsafe with the wearable, with most reports occurring prior to the availability of bracelet-like wearable covers. CONCLUSIONS: Study protocols implementing wearables and complimentary daily diaries are feasible in this urban population. However, important contextual factors including participant and researcher training and safety concerns warrant additional considerations for acceptable utilization of wearable devices for research in other low-resource settings. CI - © The Author(s) 2024. FAU - Nielsen, Karen AU - Nielsen K AUID- ORCID: 0000-0003-3771-5272 AD - School of Public Health, Georgia State University, Atlanta, GA, USA. FAU - Mobley, Kate AU - Mobley K AD - School of Data Science and Analytics, Kennesaw State University, Kennesaw, GA, USA. FAU - Culbreth, Rachel AU - Culbreth R AD - Toxicology Investigators Consortium, American College of Medical Toxicology, Phoenix, AZ, USA. FAU - Palmier, Jane AU - Palmier J AD - Wellstar College of Health and Human Services, Kennesaw State University, Kennesaw, GA, USA. FAU - Nabulya, Anna AU - Nabulya A AD - Uganda Youth Development Link, Kampala, Uganda. FAU - Swahn, Monica H AU - Swahn MH AD - Wellstar College of Health and Human Services, Kennesaw State University, Kennesaw, GA, USA. LA - eng GR - R01 MH128930/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20241018 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC11489944 OTO - NOTNLM OT - Uganda OT - Wearables < personalised medicine OT - activity trackers OT - diaries < personalised medicine OT - environment < lifestyle OT - feasibility studies OT - mental health < psychology OT - sleep duration OT - sleep quality OT - technology < general EDAT- 2024/10/21 10:51 MHDA- 2024/10/21 10:52 PMCR- 2024/10/18 CRDT- 2024/10/21 05:52 PHST- 2024/05/03 00:00 [received] PHST- 2024/09/13 00:00 [accepted] PHST- 2024/10/21 10:52 [medline] PHST- 2024/10/21 10:51 [pubmed] PHST- 2024/10/21 05:52 [entrez] PHST- 2024/10/18 00:00 [pmc-release] AID - 10.1177_20552076241288754 [pii] AID - 10.1177/20552076241288754 [doi] PST - epublish SO - Digit Health. 2024 Oct 18;10:20552076241288754. doi: 10.1177/20552076241288754. eCollection 2024 Jan-Dec. PMID- 31815621 OWN - NLM STAT- MEDLINE DCOM- 20200915 LR - 20240723 IS - 1478-4491 (Electronic) IS - 1478-4491 (Linking) VI - 17 IP - 1 DP - 2019 Dec 9 TI - 'Everything was just getting worse and worse': deteriorating job quality as a driver of doctor emigration from Ireland. PG - 97 LID - 10.1186/s12960-019-0424-y [doi] LID - 97 AB - BACKGROUND: Medicine is a high-status, high-skill occupation which has traditionally provided access to good quality jobs and relatively high salaries. In Ireland, historic underfunding combined with austerity-related cutbacks has negatively impacted job quality to the extent that hospital medical jobs have begun to resemble extreme jobs. Extreme jobs combine components of a good quality job-high pay, high job control, challenging demands, with those of a low-quality job-long working hours, heavy workloads. Deteriorating job quality and the normalisation of extreme working is driving doctor emigration from Ireland and deterring return. METHODS: Semi-structured qualitative interviews were conducted with 40 Irish emigrant doctors in Australia who had emigrated from Ireland since 2008. Interviews were held in July-August 2018. RESULTS: Respondents reflected on their experiences of working in the Irish health system, describing hospital workplaces that were understaffed, overstretched and within which extreme working had become normalised, particularly in relation to long working hours, fast working pace, doing more with less and fighting a climate of negativity. Drawing on Hirschman's work on exit, voice and loyalty (1970), the authors consider doctor emigration as exit and present respondent experiences of voice prior to emigration. Only 14/40 respondent emigrant doctors intend to return to work in Ireland. DISCUSSION: The deterioration in medical job quality and the normalisation of extreme working is a key driver of doctor emigration from Ireland, and deterring return. Irish trained hospital doctors emigrate to access good quality jobs in Australia and are increasingly likely to remain abroad once they have secured them. To improve doctor retention, health systems and employers must mitigate a gainst the emergence of extreme work in healthcare. Employee voice (about working conditions, about patient safety, etc.) should be encouraged and used to inform health system improvement and to mitigate exit. FAU - Humphries, N AU - Humphries N AUID- ORCID: 0000-0003-2959-1652 AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. niamhhumphries@rcpi.ie. FAU - McDermott, A M AU - McDermott AM AD - Cardiff Business School, Cardiff University, Cardiff, UK. FAU - Conway, E AU - Conway E AD - Dublin City University Business School, Dublin City University, Dublin, Ireland. FAU - Byrne, J-P AU - Byrne JP AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. FAU - Prihodova, L AU - Prihodova L AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. FAU - Costello, R AU - Costello R AD - Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Matthews, A AU - Matthews A AD - School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland. LA - eng GR - Emerging Investigator Award (EIA-2017-022)./HRBI_/Health Research Board/Ireland PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191209 PL - England TA - Hum Resour Health JT - Human resources for health JID - 101170535 SB - IM MH - Adult MH - *Attitude of Health Personnel MH - Australia MH - Emigrants and Immigrants/*psychology/statistics & numerical data MH - Emigration and Immigration/statistics & numerical data MH - Female MH - Foreign Medical Graduates/*psychology/*statistics & numerical data MH - Humans MH - Interviews as Topic MH - Ireland/ethnology MH - *Job Satisfaction MH - Male MH - Physicians/psychology/statistics & numerical data MH - Professional Practice Location/*statistics & numerical data MH - Workload/psychology/statistics & numerical data MH - Young Adult PMC - PMC6902557 OTO - NOTNLM OT - Austerity OT - Extreme work OT - Job quality OT - Medicine OT - Migration OT - Qualitative COIS- The authors declare that they have no competing interests. EDAT- 2019/12/10 06:00 MHDA- 2020/09/17 06:00 PMCR- 2019/12/09 CRDT- 2019/12/10 06:00 PHST- 2019/07/10 00:00 [received] PHST- 2019/10/21 00:00 [accepted] PHST- 2019/12/10 06:00 [entrez] PHST- 2019/12/10 06:00 [pubmed] PHST- 2020/09/17 06:00 [medline] PHST- 2019/12/09 00:00 [pmc-release] AID - 10.1186/s12960-019-0424-y [pii] AID - 424 [pii] AID - 10.1186/s12960-019-0424-y [doi] PST - epublish SO - Hum Resour Health. 2019 Dec 9;17(1):97. doi: 10.1186/s12960-019-0424-y. PMID- 39292457 OWN - NLM STAT- MEDLINE DCOM- 20240918 LR - 20240921 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 9 DP - 2024 Sep 3 TI - A Patient-Centered Perspective on Changes in Personal Characteristics After Deep Brain Stimulation. PG - e2434255 LID - 10.1001/jamanetworkopen.2024.34255 [doi] LID - e2434255 AB - IMPORTANCE: Deep brain stimulation (DBS) results in improvements in motor function and quality of life in patients with Parkinson disease (PD), which might impact a patient's perception of valued personal characteristics. Prior studies investigating whether DBS causes unwanted changes to oneself or one's personality have methodological limitations that should be addressed. OBJECTIVE: To determine whether DBS is associated with changes in characteristics that patients with PD identify as personally meaningful. DESIGN, SETTING, AND PARTICIPANTS: This cohort study assessed changes in visual analog scale (VAS) ratings reflecting the extent to which patients with PD manifested individually identified personal characteristics before and 6 and 12 months after DBS at a large academic medical center from February 21, 2018, to December 9, 2021. The VAS findings were tailored to reflect the top 3 individually identified personal characteristics the patient most feared losing. The VASs were scored from 0 to 10, with 0 representing the least and 10 the most extreme manifestation of the trait. Change scores were examined at the individual level. Content analysis was used to code the qualitative data. Qualitative and quantitative analyses were performed from January 12, 2019 (initial qualitative coding), to December 15, 2023. EXPOSURE: Deep brain stimulation. MAIN OUTCOMES AND MEASURES: The primary outcome variable was the mean VAS score for the top 3 personal characteristics. The secondary outcome was the incidence of meaningful changes on the patients' top 3 characteristics at the individual level. RESULTS: Fifty-two of 54 dyads of patients with PD and their care partners (96.3%) were recruited from a consecutive series approved for DBS (36 patients [69.2%] were male and 45 care partners [86.5%] were female; mean [SD] age of patients, 61.98 [8.55] years). Two patients and 1 care partner were lost to follow-up. Increases in the mean VAS score (indicative of greater manifestation of [ie, positive changes in] specific characteristics) were apparent following DBS for ratings of both the patients (Wald χ2 = 16.104; P < .001) and care partners (Wald χ2 = 6.746; P < .001) over time. The slopes of the changes for both the patient and care partners were correlated, indicating agreement in observed changes over time. The individual level analyses indicated that scores for most patients and care partners remained the same or increased. CONCLUSIONS AND RELEVANCE: In this cohort study, participants reported greater (more positive) manifestations of individually identified, valued characteristics after DBS. These findings may be relevant to informing decision-making for patients with advanced PD who are considering DBS. FAU - Merner, Amanda R AU - Merner AR AD - Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio. AD - Center for Bioethics, Harvard Medical School, Boston, Massachusetts. FAU - Frazier, Thomas W AU - Frazier TW AD - Department of Psychology, John Carroll University, University Heights, Ohio. AD - Department of Pediatrics, SUNY Upstate New York, Syracuse. AD - Department of Psychology, SUNY Upstate New York, Syracuse. FAU - Ford, Paul J AU - Ford PJ AD - Center for Bioethics, Cleveland Clinic, Cleveland, Ohio. AD - Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. FAU - Lapin, Brittany AU - Lapin B AD - Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. AD - Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. AD - Center for Outcomes Research and Evaluation, Neurological Institute, Cleveland Clinic, Cleveland, Ohio. FAU - Wilt, Joshua AU - Wilt J AD - Department of Psychological Sciences, Case Western Reserve University, Cleveland, Ohio. FAU - Racine, Eric AU - Racine E AD - Montreal Clinical Research Institute, Montreal, Quebec, Canada. AD - Department of Medicine, Université de Montréal, Montreal, Quebec, Canada. AD - Department of Medicine, McGill University, Montreal, Quebec, Canada. FAU - Gase, Natalie AU - Gase N AD - Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio. FAU - Leslie, Essence AU - Leslie E AD - Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio. FAU - Machado, Andre AU - Machado A AD - Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio. AD - Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. FAU - Vitek, Jerrold L AU - Vitek JL AD - Department of Neurology, University of Minnesota, Minneapolis. FAU - Kubu, Cynthia S AU - Kubu CS AD - Center for Neurological Restoration, Cleveland Clinic, Cleveland, Ohio. AD - Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio. LA - eng PT - Journal Article DEP - 20240903 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Deep Brain Stimulation/methods MH - Male MH - Female MH - *Parkinson Disease/therapy/psychology MH - Middle Aged MH - Aged MH - Cohort Studies MH - Quality of Life/psychology MH - Patient-Centered Care MH - Visual Analog Scale PMC - PMC11411387 COIS- Conflict of Interest Disclosures: Dr Frazier reported owning an investor stake in Autism EYES LLC and iSCAN-R, owning stock options or equity in Quadrant Biosciences, MARABio, and Springtide Research Institute, and receiving funding from SynGAP and PTEN research funds outside the submitted work. Dr Frazier also reported receiving funding or research support, travel support, and/or speaker’s honoraria from or consulting for the PTEN Research Foundation, SynGAP Research Fund, Malan Syndrome Foundation, ADNP Kids Research Foundation, Quadrant Biosciences, Autism Speaks Inc, Impel NeuroPharma, F. Hoffman–La Roche AG Pharmaceuticals, the Cole Family Research Fund, Simons Foundation, Ingalls Foundation, Forest Laboratories, Ecoeos, IntegraGen, Kugona, Shire Development, Bristol Myers Squibb, Roche Pharma, MARAbio, Scioto Biosciences, the National Institutes of Health (NIH), and the Brain and Behavior Research Foundation. Dr Wilt reported receiving support from the Templeton Religion Trust, International Research Network for the Study of Science and Belief in Society, and John Templeton Foundation. Dr Machado reported receiving funding from the NIH BRAIN Initiative poststroke or post–traumatic brain injury rehabilitation; consulting for Abbott Laboratories and Novo Nordisk outside the submitted work; developing intellectual property licensed to Cardionomic Inc; participating in data safety monitoring boards of NIH-supported studies; and serving as chief scientific officer for Enspire and Ceraxis Health. Dr Vitek reported consulting for Boston Scientific Corporation, Medtronic, Abbott Laboratories, and University of Michigan, Grand Rounds, receiving grant support from the NIH, and having equity interest in and serving on the scientific advisory board for Surgical Information Sciences outside the submitted work. No other disclosures were reported. EDAT- 2024/09/18 12:50 MHDA- 2024/09/18 12:51 PMCR- 2024/09/18 CRDT- 2024/09/18 11:33 PHST- 2024/09/18 12:51 [medline] PHST- 2024/09/18 12:50 [pubmed] PHST- 2024/09/18 11:33 [entrez] PHST- 2024/09/18 00:00 [pmc-release] AID - 2823673 [pii] AID - zoi241021 [pii] AID - 10.1001/jamanetworkopen.2024.34255 [doi] PST - epublish SO - JAMA Netw Open. 2024 Sep 3;7(9):e2434255. doi: 10.1001/jamanetworkopen.2024.34255. PMID- 21249854 STAT- Publisher PB - Agency for Healthcare Research and Quality CTI - Advances in Patient Safety DP - 2008 Aug TI - Home Health Care Patients and Safety Hazards in the Home: Preliminary Findings. BTI - Advances in Patient Safety: New Directions and Alternative Approaches (Vol. 1: Assessment) AB - Introduction: Home health care is the fastest growing sector in the health care industry, with an anticipated growth of 66 percent over the next 10 years and with over 7 million patients served each year. With the increasing acuteness of care provided in home health care and the increasing number of frail elderly that make up this patient population, it is important to identify risk factors that affect patient health and safety in this setting. Methods: A convenience sample of 1,561 home health aides, attendants, and personal care workers completed a risk assessment survey. Items addressed personal, patient, and home characteristics and health hazards. All activities had prior Institutional Review Board approval. Preliminary Results: Ninety-five percent of home health care workers (HHCWs) were female with an average of 8 years experience. The majority of clients were elderly, with a smaller percentage of adult (26 percent) and pediatric (7 percent) cases. HHCWs reported the following exposures at their clients’ homes: cockroaches (33 percent), cigarette smoke (30 percent), vermin (23 percent), irritating chemicals (17 percent), and peeling paint (15 percent). The following conditions were also described: clutter (17 percent), temperature extremes (9 percent), unsanitary (12 percent) and unsafe (6 percent) conditions in the home, neighborhood violence/crime (11 percent), and aggressive pets (6 percent). Two percent of respondents reported the presence of guns in the home. Additionally, 12 percent of HHCWs reported signs of abuse of their clients. Conclusion: Both HHCWs and home care patients appear to be at potential risk due to a variety of health hazards/exposures in the clients’ homes. Given the growing population of both HHCWs and recipients, it is important to document this risk as an important first step in prevention and management. FED - Henriksen, Kerm ED - Henriksen K FED - Battles, James B ED - Battles JB FED - Keyes, Margaret A ED - Keyes MA FED - Grady, Mary L ED - Grady ML FAU - Gershon, Robyn RM AU - Gershon RRM AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Pogorzelska, Monika AU - Pogorzelska M AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Qureshi, Kristine A AU - Qureshi KA AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Stone, Patricia W AU - Stone PW AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Canton, Allison N AU - Canton AN AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Samar, Stephanie M AU - Samar SM AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Westra, Leah J AU - Westra LJ AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Damsky, Marc R AU - Damsky MR AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Sherman, Martin AU - Sherman M AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) LA - eng PT - Review PT - Book Chapter PL - Rockville (MD) EDAT- 2008/08/01 00:00 CRDT- 2008/08/01 00:00 AID - NBK43619 [bookaccession] PMID- 30065683 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 9 DP - 2018 TI - Comparing Attachment Networks During Middle Childhood in Two Contrasting Cultural Contexts. PG - 1201 LID - 10.3389/fpsyg.2018.01201 [doi] LID - 1201 AB - Cultural psychology assumes that the ecocultural conditions of a particular setting shape children's pathways, resulting in multiple adaptive solutions to universal developmental tasks. While the adaptivity of attachment and children's psychosocial development during the early years has been thoroughly investigated, attachment research during middle childhood continues to reflect Western ideals of family. Adhering to ideas of monotropy, most studies only focus on parental attachment figures. However, this restricted empirical perspective does not only result in a Eurocentric bias, it also neglects theoretical reflections on the growing complexity of attachment during middle childhood, thus only considering a limited selection of all individuals contributing to the children's feeling of security, even in Western settings. To investigate the variability and adaptivity of attachment during middle childhood, this study assessed children's attachment figures in two extreme settings of development, introducing an exhaustive network perspective on attachment during this developmental stage. Children of the Cameroonian Nseh (N = 11) and German children from Bad Nauheim (N = 11) identified and differentiated all individuals contributing to their attachment need in an exploratory and transdisciplinary approach. The socio-structural composition of children's attachment networks follows the context-specific systems of care and concepts of interconnectedness and the ecological features of each setting, resulting in marked differences between both contexts. The functional composition, however, reflects children's preoccupation with similar developmental challenges across settings. Same-aged peers contribute to the children's feeling of safety in both settings, thereby deviating from previous reflections on their subordinate relevance during middle childhood. Overall, these results support the adaptiveness of children's attachment patterns while also demonstrating universal trends across contexts. They highlight the collective nature of attachment during middle childhood that exceeds the impact of individual dyads. Thus, broad and context-sensitive research strategies become a necessary addition to attachment research in order to generate an exhaustive understanding for children's development across cultural contexts. FAU - Becke, Sophia D AU - Becke SD AD - Department of Psychology, Goethe University Frankfurt, Frankfurt, Germany. FAU - Bongard, Stephan AU - Bongard S AD - Department of Psychology, Goethe University Frankfurt, Frankfurt, Germany. LA - eng PT - Journal Article DEP - 20180717 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC6057239 OTO - NOTNLM OT - Cameroon OT - Germany OT - attachment figures OT - attachment networks OT - cross-cultural comparison OT - developmental task OT - ecocultural approach OT - middle childhood EDAT- 2018/08/02 06:00 MHDA- 2018/08/02 06:01 PMCR- 2018/07/17 CRDT- 2018/08/02 06:00 PHST- 2018/02/21 00:00 [received] PHST- 2018/06/22 00:00 [accepted] PHST- 2018/08/02 06:00 [entrez] PHST- 2018/08/02 06:00 [pubmed] PHST- 2018/08/02 06:01 [medline] PHST- 2018/07/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2018.01201 [doi] PST - epublish SO - Front Psychol. 2018 Jul 17;9:1201. doi: 10.3389/fpsyg.2018.01201. eCollection 2018. PMID- 31890332 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231027 IS - 2093-7911 (Print) IS - 2093-7997 (Electronic) IS - 2093-7911 (Linking) VI - 10 IP - 4 DP - 2019 Dec TI - The Third Version of the Copenhagen Psychosocial Questionnaire. PG - 482-503 LID - 10.1016/j.shaw.2019.10.002 [doi] AB - INTRODUCTION: A new third version of the Copenhagen Psychosocial Questionnaire (COPSOQ III) has been developed in response to trends in working life, theoretical concepts, and international experience. A key component of the COPSOQ III is a defined set of mandatory core items to be included in national short, middle, and long versions of the questionnaire. The aim of the present article is to present and test the reliability of the new international middle version of the COPSOQ III. METHODS: The questionnaire was tested among 23,361 employees during 2016-2017 in Canada, Spain, France, Germany, Sweden, and Turkey. A total of 26 dimensions (measured through scales or single items) of the middle version and two from the long version were tested. Psychometric properties of the dimensions were assessed regarding reliability (Cronbach α), ceiling and floor effects (fractions with extreme answers), and distinctiveness (correlations with other dimensions). RESULTS: Most international middle dimensions had satisfactory reliability in most countries, though some ceiling and floor effects were present. Dimensions with missing values were rare. Most dimensions had low to medium intercorrelations. CONCLUSIONS: The COPSOQ III offers reliable and distinct measures of a wide range of psychosocial dimensions of modern working life in different countries; although a few measures could be improved. Future testing should focus on validation of the COPSOQ items and dimensions using both qualitative and quantitative approaches. Such investigations would enhance the basis for recommendations using the COPSOQ III. CI - © 2019 The Authors. FAU - Burr, Hermann AU - Burr H AD - Division 3 Work and Health, Federal Institute of Occupational Safety and Health (BAuA), Berlin, Germany. FAU - Berthelsen, Hanne AU - Berthelsen H AD - Center for Work Life and Evaluation Studies (CTA) and the Faculty of Odontology, Malmö University, Malmö, Sweden. FAU - Moncada, Salvador AU - Moncada S AD - Union Institute of Work, Environment and Health (ISTAS), Barcelona, Spain. FAU - Nübling, Matthias AU - Nübling M AD - Freiburg Research Centre for Occupational Sciences (FFAW), Freiburg, Germany. FAU - Dupret, Emilie AU - Dupret E AD - Preventis, Paris, France. FAU - Demiral, Yucel AU - Demiral Y AD - Department of Public Health, Dokuz Eylul University, Izmir, Turkey. FAU - Oudyk, John AU - Oudyk J AD - Occupational Health Clinics for Ontario Workers (OHCOW), Hamilton, Canada. FAU - Kristensen, Tage S AU - Kristensen TS AD - Task-Consult, Gilleleje, Denmark. FAU - Llorens, Clara AU - Llorens C AD - Union Institute of Work, Environment and Health (ISTAS), Barcelona, Spain. AD - Research Group on Psychosocial Risks, Organization of Work and Health (POWAH), Autonomous University of Barcelona, Barcelona, Spain. FAU - Navarro, Albert AU - Navarro A AD - Research Group on Psychosocial Risks, Organization of Work and Health (POWAH), Autonomous University of Barcelona, Barcelona, Spain. AD - Biostatistics Unit, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain. FAU - Lincke, Hans-Joachim AU - Lincke HJ AD - Freiburg Research Centre for Occupational Sciences (FFAW), Freiburg, Germany. FAU - Bocéréan, Christine AU - Bocéréan C AD - Preventis, Paris, France. AD - Lorraine University, Nancy, France. FAU - Sahan, Ceyda AU - Sahan C AD - Department of Public Health, Dokuz Eylul University, Izmir, Turkey. FAU - Smith, Peter AU - Smith P AD - Institute for Work and Health (IWH), Toronto, ON, Canada. AD - Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Australia. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Pohrt, Anne AU - Pohrt A AD - Institut für Medizinische Psychologie, Charité-Universitätsmedizin Berlin, Berlin, Germany. CN - international COPSOQ Network LA - eng PT - Journal Article DEP - 20191106 PL - Korea (South) TA - Saf Health Work JT - Safety and health at work JID - 101542940 PMC - PMC6933167 OTO - NOTNLM OT - Psychosocial risk factors OT - Psychosocial working conditions OT - Risk assessment COIS- The authors declare no conflict of interest. EDAT- 2020/01/01 06:00 MHDA- 2020/01/01 06:01 PMCR- 2019/11/06 CRDT- 2020/01/01 06:00 PHST- 2018/07/25 00:00 [received] PHST- 2019/09/20 00:00 [revised] PHST- 2019/10/23 00:00 [accepted] PHST- 2020/01/01 06:00 [entrez] PHST- 2020/01/01 06:00 [pubmed] PHST- 2020/01/01 06:01 [medline] PHST- 2019/11/06 00:00 [pmc-release] AID - S2093-7911(18)30272-5 [pii] AID - 10.1016/j.shaw.2019.10.002 [doi] PST - ppublish SO - Saf Health Work. 2019 Dec;10(4):482-503. doi: 10.1016/j.shaw.2019.10.002. Epub 2019 Nov 6. PMID- 35409727 OWN - NLM STAT- MEDLINE DCOM- 20220413 LR - 20220510 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 19 IP - 7 DP - 2022 Mar 29 TI - The Seroprevalence of SARS-CoV-2 Antibodies among HealthCare Workers in University Hospital in Krakow before the Era of Vaccination. LID - 10.3390/ijerph19074044 [doi] LID - 4044 AB - BACKGROUND: Knowledge of occupational health is crucial to the safety of healthcare workers in the pandemic period. The aim of our study was the rating of SARS-CoV-2 seroprevalence in connection with selected demographic, social, and organizational factors, as well as the identification of key elements determining the safety of HCWs and patients of the University Hospital in Krakow. METHODS: This was a non-interventional, uncontrolled, open, single-center, cross-sectional online survey on the preparedness for the COVID-19 epidemic and the seroprevalence of medical and non-medical HCWs and students. Serum specimens from 1221 persons were tested using an immunoassay analyzer based on the ECLIA technique for the anti-SARS-CoV-2 antibodies IgM + IgG. RESULTS: The total seroprevalence was 42.7%. In medical students it was 25.2%, while in physicians it was 43.4% and in nurses/midwives it was 48.1%. Of those who tested positive, 21.5% did not know their serological status. The use of personal protective equipment did not have any significant impact on the result of testing for anti-SARS-CoV-2 antibodies. The risk of developing the disease was not influenced by sex, professional work experience, workplace, or intensity of contact with the patient. Among the studied elements, only care of COVID-19 patients significantly increased the risk. The protective factor was starting work between the waves of the epidemic (June-September 2020). CONCLUSIONS: PPE is only one element of infection prevention and control-without other components, such as hand hygiene, it can be dangerous and contribute to self-infection. It is also very important to test healthcare workers. Not being aware of the COVID-19 status of HCWs poses a threat to other staff members, as well as patients and the family and friends of the infected. Thus, extreme caution should be applied when employing respirators with exhalation valves during the COVID-19 pandemic. FAU - Żółtowska, Barbara AU - Żółtowska B AUID- ORCID: 0000-0002-1771-4558 AD - Center for Innovative Therapy, Clinical Research Coordination Center, University Hospital in Krakow, 30-688 Krakow, Poland. FAU - Barańska, Ilona AU - Barańska I AD - Laboratory for Research on Aging Society, Department of Sociology of Medicine, Chair of Epidemiology and Preventive Medicine, Medical Faculty, Jagiellonian University Medical College, 31-034 Krakow, Poland. FAU - Jachowicz, Estera AU - Jachowicz E AD - Chair of Microbiology, Medical Faculty, Jagiellonian University Medical College, 31-121 Krakow, Poland. FAU - Sydor, Wojciech AU - Sydor W AD - Center for Innovative Therapy, Clinical Research Coordination Center, University Hospital in Krakow, 30-688 Krakow, Poland. AD - Department of Rheumatology and Immunology, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Maziarz, Barbara AU - Maziarz B AD - Department of Clinical Biochemistry, Jagiellonian University Medical College, 31-066 Krakow, Poland. FAU - Mydel, Krzysztof AU - Mydel K AD - Deputy Director for Coordination and Development, University Hospital in Krakow, 30-688 Krakow, Poland. FAU - Różańska, Anna AU - Różańska A AD - Chair of Microbiology, Medical Faculty, Jagiellonian University Medical College, 31-121 Krakow, Poland. FAU - Wizner, Barbara AU - Wizner B AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Rosiński, Jerzy AU - Rosiński J AUID- ORCID: 0000-0002-8348-2839 AD - Faculty of Management and Social Communication, The Institute of Economics, Finance and Management, Jagiellonian University, 30-348 Krakow, Poland. FAU - Kossowska, Magdalena AU - Kossowska M AD - Faculty of Management and Social Communication, The Institute of Economics, Finance and Management, Jagiellonian University, 30-348 Krakow, Poland. FAU - Głomb, Kaja AU - Głomb K AD - Faculty of Management and Social Communication, The Institute of Applied Psychology, Jagiellonian University, 30-348 Krakow, Poland. FAU - Wójkowska-Mach, Jadwiga AU - Wójkowska-Mach J AUID- ORCID: 0000-0003-0756-1639 AD - Chair of Microbiology, Medical Faculty, Jagiellonian University Medical College, 31-121 Krakow, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220329 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Antibodies, Viral) RN - 0 (Immunoglobulin G) SB - IM MH - Antibodies, Viral MH - *COVID-19/epidemiology MH - Cross-Sectional Studies MH - Health Personnel MH - Hospitals, University MH - Humans MH - Immunoglobulin G MH - Pandemics/prevention & control MH - *SARS-CoV-2 MH - Seroepidemiologic Studies MH - Vaccination PMC - PMC8997762 OTO - NOTNLM OT - COVID-19 OT - healthcare workers OT - infection prevention and control practices OT - seroprevalence OT - work culture COIS- The authors have no conflict of interest to disclose. The manuscript has been read and approved by all authors. EDAT- 2022/04/13 06:00 MHDA- 2022/04/14 06:00 PMCR- 2022/03/29 CRDT- 2022/04/12 01:14 PHST- 2022/01/18 00:00 [received] PHST- 2022/03/21 00:00 [revised] PHST- 2022/03/24 00:00 [accepted] PHST- 2022/04/12 01:14 [entrez] PHST- 2022/04/13 06:00 [pubmed] PHST- 2022/04/14 06:00 [medline] PHST- 2022/03/29 00:00 [pmc-release] AID - ijerph19074044 [pii] AID - ijerph-19-04044 [pii] AID - 10.3390/ijerph19074044 [doi] PST - epublish SO - Int J Environ Res Public Health. 2022 Mar 29;19(7):4044. doi: 10.3390/ijerph19074044. PMID- 21827293 OWN - NLM STAT- MEDLINE DCOM- 20120720 LR - 20220409 IS - 1745-7319 (Electronic) IS - 1745-7300 (Linking) VI - 19 IP - 1 DP - 2012 TI - A qualitative approach to the intangible cost of road traffic injuries. PG - 69-79 LID - 10.1080/17457300.2011.603155 [doi] AB - The consequences of fatal and non-fatal road traffic injuries (RTI) at the personal and household levels were analysed using qualitative interviews of 12 injured and of 12 relatives of people who died for this reason. Collisions change physical and mental health both of the injured and of their relatives. This leads to changes in daily activities and even to the redefinition of future life. RTI also changes the way people see and act in life, becoming an experience that teaches them. Survivors commonly transmit a road safety message afterwards. Changes in family life were evident (in extreme cases family's composition also changed), affecting intra-familial relationships. Associated unexpected and unplanned expenditures and loss of income have consequences in the short, medium and long term that unbalance household's economies and immerse people into a constant stress. Individuals and family's future plans are occasionally condition to whether they have or not debts. Household dependence in economic terms was sometimes observed, as well as uncertainty about future life and household's sustainability. Sometimes, households change and adapt their life to what they now are able to afford, having important repercussions in vital spheres. FAU - Pérez-Núñez, Ricardo AU - Pérez-Núñez R AD - Centro de Investigación en Sistemas de Salud del Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México. FAU - Pelcastre-Villafuerte, Blanca AU - Pelcastre-Villafuerte B FAU - Híjar, Martha AU - Híjar M FAU - Avila-Burgos, Leticia AU - Avila-Burgos L FAU - Celis, Alfredo AU - Celis A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110809 PL - England TA - Int J Inj Contr Saf Promot JT - International journal of injury control and safety promotion JID - 101247254 SB - IM MH - Accidents, Traffic/economics/*psychology MH - *Cost of Illness MH - Family Relations MH - Humans MH - Income MH - Interviews as Topic MH - *Life Change Events MH - Qualitative Research MH - Quality of Life/*psychology MH - Stress, Psychological/etiology MH - Survivors/psychology MH - Wounds and Injuries/economics/psychology EDAT- 2011/08/11 06:00 MHDA- 2012/07/21 06:00 CRDT- 2011/08/11 06:00 PHST- 2011/08/11 06:00 [entrez] PHST- 2011/08/11 06:00 [pubmed] PHST- 2012/07/21 06:00 [medline] AID - 10.1080/17457300.2011.603155 [doi] PST - ppublish SO - Int J Inj Contr Saf Promot. 2012;19(1):69-79. doi: 10.1080/17457300.2011.603155. Epub 2011 Aug 9. PMID- 22854151 OWN - NLM STAT- MEDLINE DCOM- 20121015 LR - 20220318 IS - 1488-2310 (Electronic) IS - 0008-428X (Print) IS - 0008-428X (Linking) VI - 55 IP - 4 DP - 2012 Aug TI - Is Canadian surgical residency training stressful? PG - S145-51 LID - 10.1503/cjs.002911 [doi] AB - BACKGROUND: Surgical residency has the reputation of being arduous and stressful. We sought to determine the stress levels of surgical residents, the major causes of stress and the coping mechanisms used. METHODS: We developed and distributed a survey among surgical residents across Canada. RESULTS: A total of 169 participants responded: 97 (57%) male and 72 (43%) female graduates of Canadian (83%) or foreign (17%) medical schools. In all, 87% reported most of the past year of residency as somewhat stressful to extremely stressful, with time pressure (90%) being the most important stressor, followed by number of working hours (83%), residency program (73%), working conditions (70%), caring for patients (63%) and financial situation (55%). Insufficient sleep and frequent call was the component of residency programs that was most commonly rated as highly stressful (31%). Common coping mechanisms included staying optimistic (86%), engaging in enjoyable activities (83%), consulting others (75%) and exercising (69%). Mental or emotional problems during residency were reported more often by women (p = 0.006), who were also more likely than men to seek help (p = 0.026), but men reported greater financial stress (p = 0.036). Foreign graduates reported greater stress related to working conditions (p < 0.001), residency program (p = 0.002), caring for family members (p = 0.006), discrimination (p < 0.001) and personal and family safety (p < 0.001) than Canadian graduates. CONCLUSION: Time pressure and working hours were the most common stressors overall, and lack of sleep and call frequency were the most stressful components of the residency program. Female sex and graduating from a non-Canadian medical school increased the likelihood of reporting stress in certain areas of residency. FAU - Aminazadeh, Nasser AU - Aminazadeh N AD - McMaster University, Hamilton, Ontario. aminazadeh@hotmail.com FAU - Farrokhyar, Forough AU - Farrokhyar F FAU - Naeeni, Amir AU - Naeeni A FAU - Naeeni, Marjan AU - Naeeni M FAU - Reid, Susan AU - Reid S FAU - Kashfi, Arash AU - Kashfi A FAU - Kahnamoui, Kamyar AU - Kahnamoui K LA - eng PT - Comparative Study PT - Journal Article PL - Canada TA - Can J Surg JT - Canadian journal of surgery. Journal canadien de chirurgie JID - 0372715 SB - IM MH - Adult MH - Canada MH - Cross-Sectional Studies MH - Education, Medical, Graduate/organization & administration MH - Female MH - General Surgery/education MH - Hospitals, Teaching MH - Humans MH - Internship and Residency/*organization & administration MH - Job Satisfaction MH - Male MH - Needs Assessment MH - Personal Satisfaction MH - Stress, Psychological/*epidemiology MH - Surveys and Questionnaires MH - Time Factors MH - Work Schedule Tolerance/*psychology MH - *Workload MH - Young Adult PMC - PMC3432247 EDAT- 2012/08/03 06:00 MHDA- 2012/10/16 06:00 PMCR- 2012/08/01 CRDT- 2012/08/03 06:00 PHST- 2012/08/03 06:00 [entrez] PHST- 2012/08/03 06:00 [pubmed] PHST- 2012/10/16 06:00 [medline] PHST- 2012/08/01 00:00 [pmc-release] AID - 10.1503/cjs.002911 [pii] AID - 055s145 [pii] AID - 10.1503/cjs.002911 [doi] PST - ppublish SO - Can J Surg. 2012 Aug;55(4):S145-51. doi: 10.1503/cjs.002911. PMID- 35678625 OWN - NLM STAT- MEDLINE DCOM- 20220627 LR - 20231013 IS - 1541-4159 (Electronic) IS - 0047-2379 (Print) IS - 0047-2379 (Linking) VI - 50 IP - 3-4 DP - 2021 Sep TI - Peer Crowd Identification of Young and Early Middle Adulthood Customers at Vape Shops. PG - 98-107 LID - 10.1177/00472379221106365 [doi] AB - Vape shops specialize in the sales of e-cigarettes and other vaping products. In recent studies, young adults who use e-cigarettes have tended to identify with at-risk peer crowds. This is the first study to examine vape shop customers' clientele. Composed primarily of young adults and persons in early middle adulthood, we speculated that a relatively high prevalence of those who appeared to bystanders as radical/extreme (at-risk) customers would be identified as such at these shops. We recruited vape shops throughout Southern California (N = 44 shops), and trained teams of data collectors visited each of the consented vape shops, making note of 451 customers' appearance, including features such as manner of dress, presence of tattoos, and hairstyles. Customers were then coded as either belonging to a conventional, progressive, or radical/extreme crowd based on outward appearance. Of the customers observed, 223 (49%) were rated as appearing to be in the conventional crowd; 169 (38%) were rated as appearing to be in the progressive crowd, and only 59 (13%) were rated as appearing to be in the radical/extreme crowd. The conventional crowd tended to appear older. Clientele may reflect that more conventional young and early middle age adults are tempted to visit vape shops due to perceptions of greater acceptability or safety of e-cigarettes. E-cigarette mass media campaigns aimed at protecting potential vape shop customers from harm may need to depict more conservative-looking characters. FAU - Sussman, Steve AU - Sussman S AUID- ORCID: 0000-0002-6778-9718 AD - Institute for Health Promotion and Disease Prevention, Department of Population and Public Health Sciences, Keck School of Medicine, 5116University of Southern California, Los Angeles, CA, USA. AD - Department of Psychology, 5116University of Southern California, Los Angeles, CA, USA. AD - School of Social Work, 5116University of Southern California, Los Angeles, CA, USA. FAU - Galimov, Artur AU - Galimov A AD - Institute for Health Promotion and Disease Prevention, Department of Population and Public Health Sciences, Keck School of Medicine, 5116University of Southern California, Los Angeles, CA, USA. FAU - Meza, Leah AU - Meza L AD - Institute for Health Promotion and Disease Prevention, Department of Population and Public Health Sciences, Keck School of Medicine, 5116University of Southern California, Los Angeles, CA, USA. FAU - Huh, Jimi AU - Huh J AD - Institute for Health Promotion and Disease Prevention, Department of Population and Public Health Sciences, Keck School of Medicine, 5116University of Southern California, Los Angeles, CA, USA. FAU - Baezconde-Garbanati, Lourdes AU - Baezconde-Garbanati L AD - Institute for Health Promotion and Disease Prevention, Department of Population and Public Health Sciences, Keck School of Medicine, 5116University of Southern California, Los Angeles, CA, USA. FAU - Pokhrel, Pallav AU - Pokhrel P AD - Population Sciences Program, 3947University of Hawaii Cancer Center, Honolulu, HI, USA. LA - eng GR - R01 CA228905/CA/NCI NIH HHS/United States GR - P50 CA180905/CA/NCI NIH HHS/United States GR - R01 DA013814/DA/NIDA NIH HHS/United States GR - R01 CA202277/CA/NCI NIH HHS/United States GR - UL1 TR001855/TR/NCATS NIH HHS/United States GR - R01 DA020138/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220609 PL - United States TA - J Drug Educ JT - Journal of drug education JID - 1300031 RN - 5J49Q6B70F (Vincristine) SB - IM MH - Adult MH - Commerce MH - *Electronic Nicotine Delivery Systems MH - Humans MH - Middle Aged MH - Peer Group MH - *Vaping/epidemiology MH - Vincristine MH - Young Adult PMC - PMC9359667 MID - NIHMS1818500 OTO - NOTNLM OT - e-cigarettes OT - peer crowds OT - vape shops COIS- Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2022/06/10 06:00 MHDA- 2022/06/28 06:00 PMCR- 2022/08/08 CRDT- 2022/06/09 09:23 PHST- 2022/06/10 06:00 [pubmed] PHST- 2022/06/28 06:00 [medline] PHST- 2022/06/09 09:23 [entrez] PHST- 2022/08/08 00:00 [pmc-release] AID - 10.1177/00472379221106365 [doi] PST - ppublish SO - J Drug Educ. 2021 Sep;50(3-4):98-107. doi: 10.1177/00472379221106365. Epub 2022 Jun 9. PMID- 29226794 OWN - NLM STAT- MEDLINE DCOM- 20180720 LR - 20180802 IS - 1461-7471 (Electronic) IS - 1363-4615 (Linking) VI - 54 IP - 5-6 DP - 2017 Oct-Dec TI - Mental health of immigrants and refugees seeking legal services on the US-Mexico border. PG - 783-805 LID - 10.1177/1363461517746316 [doi] AB - The debates on the mental health benefits associated with immigration are mixed. On the one hand, immigrants are provided with more opportunities not available in their home countries. On the other hand, they are far away from home and may have been exposed to traumatic experiences on their journeys to the receiving country. Even after settling down in the receiving country, most continue to face legal battles associated with their immigration status, as shown in this study. This study examined the risk and protective factors associated with the mental health conditions in a sample of 39 immigrants and refugees seeking legal services on the US-Mexico border. Participants were recruited from a southwestern community agency serving the region's immigrant population over the past three decades. Negative mental health states including stress, sadness, and anxiety were frequently reported by the participants. Six themes were identified as significantly related to the participants' adjustment in the US: (1) political turmoil and safety issues; (2) economic hardship and extreme poverty; (3) trauma before and after resettlement; (4) immigration status; (5) family relational strain; and (6) identity struggle and acculturation. Overall, results demonstrate the complexity of issues pertaining to cross-country migration, cultural sensitivities, and mental health. FAU - Paat, Yok-Fong AU - Paat YF AD - The University of Texas at El Paso. FAU - Green, Rachel AU - Green R AD - Diocesan Migrant & Refugee Services, Inc., El Paso, Texas. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Transcult Psychiatry JT - Transcultural psychiatry JID - 9708119 SB - IM MH - Adult MH - Female MH - Humans MH - Legal Services MH - Male MH - Mental Health/*ethnology MH - Mexico/ethnology MH - Psychological Trauma/*ethnology MH - Refugees/legislation & jurisprudence/*psychology MH - United States/ethnology OTO - NOTNLM OT - immigrants OT - legal services OT - mental health OT - refugees EDAT- 2017/12/12 06:00 MHDA- 2018/07/22 06:00 CRDT- 2017/12/12 06:00 PHST- 2017/12/12 06:00 [entrez] PHST- 2017/12/12 06:00 [pubmed] PHST- 2018/07/22 06:00 [medline] AID - 10.1177/1363461517746316 [doi] PST - ppublish SO - Transcult Psychiatry. 2017 Oct-Dec;54(5-6):783-805. doi: 10.1177/1363461517746316. PMID- 39167410 OWN - NLM STAT- MEDLINE DCOM- 20240821 LR - 20240821 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 7 IP - 8 DP - 2024 Aug 1 TI - Assessing Psychosocial Risk and Resilience to Support Readiness for Gene Therapy in Sickle Cell Disease: A Consensus Statement. PG - e2429443 LID - 10.1001/jamanetworkopen.2024.29443 [doi] AB - IMPORTANCE: The introduction of gene therapies into the clinical care landscape for individuals living with sickle cell disease (SCD) represents a momentous achievement with the potential to rewrite the story of the world's most prevalent heritable blood disorder. This disease, which was first described in 1910 and did not see a US Food and Drug Administration-approved therapeutic until 1998, is poised to be among the first to realize the promise of gene therapy and genome editing. However, the future of these treatments now rests on how evidence of safety, outcomes, and acceptance in clinical practice unfolds in SCD. Furthermore, historic injustices involving the exploitation of individuals from minoritized racial and ethnic groups in medical contexts necessitate extreme care in ensuring readiness among individuals with SCD considering genetic therapies. OBJECTIVE: To address a gap in resources focused on patient readiness for gene therapy. EVIDENCE REVIEW: The Cure Sickle Cell Initiative organized the Patient Readiness and Resilience Working Group in September 2020. Membership was comprised of behavioral health clinicians and scientists with expertise in SCD, adults with lived experience with SCD, and a caregiver. Over 2 years, the working group developed consensus recommendations and created resources to guide implementation of pregene therapy patient readiness assessments. Recommendations centered on strategies to enhance delivery of education about gene therapy and assess knowledge and understanding, interest and motivation, and psychosocial risk and resilience factors. FINDINGS: Five goals of a pregene therapy patient readiness assessment were identified: (1) gathering information about a patient's understanding of and perceived readiness for gene therapy; (2) encouraging an open dialogue; (3) providing a conceptualization of psychosocial factors that may influence participation in gene therapy; (4) identifying patient strengths that can be used to promote psychosocial well-being before, during, and after gene therapy; (5) identifying and addressing psychosocial risks. CONCLUSIONS AND RELEVANCE: Patient readiness and psychosocial factors will have tangible implications for the success of gene therapy at individual and collective levels. Health care institutions, industry, payers, policymakers, and clinicians all shoulder responsibility for ensuring that patients with SCD are adequately prepared for gene therapy and supported in ways that optimize readiness and access. Resources described here may be leveraged as a guide to support implementation of pregene therapy assessments of patient readiness and resilience in SCD. FAU - Hardy, Steven J AU - Hardy SJ AD - Center for Cancer and Blood Disorders, Children's National Hospital, Washington, DC. AD - Departments of Pediatrics and Psychiatry and Behavioral Sciences, George Washington University School of Medicine and Health Sciences, Washington, DC. FAU - Crosby, Lori E AU - Crosby LE AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio. AD - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. FAU - Porter, Jerlym S AU - Porter JS AD - Department of Psychology and Biobehavioral Sciences, St Jude Children's Research Hospital, Memphis, Tennessee. FAU - Sil, Soumitri AU - Sil S AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia. FAU - Valrie, Cecelia R AU - Valrie CR AD - Department of Psychology, Virginia Commonwealth University, Richmond, Virginia. FAU - Jonassaint, Charles R AU - Jonassaint CR AD - Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Bediako, Shawn M AU - Bediako SM AD - Center for the Advancement of Science Leadership and Culture, Howard Hughes Medical Institute, Chevy Chase, Maryland. FAU - Andrews, Clayton AU - Andrews C AD - Sickle Champions Men's Action Network, Atlanta, Georgia. FAU - Rivera, Maria AU - Rivera M AD - Sickle Cell Community Consortium, Cumming, Georgia. FAU - Woolford, Teonna AU - Woolford T AD - Sickle Cell Reproductive Health Education Directive, Baltimore, Maryland. FAU - Coleman-Cowger, Victoria H AU - Coleman-Cowger VH AD - The Emmes Company, Rockville, Maryland. LA - eng PT - Journal Article DEP - 20240801 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Anemia, Sickle Cell/therapy/genetics/psychology MH - *Genetic Therapy MH - *Resilience, Psychological MH - Consensus MH - Adult MH - Female MH - Male MH - Risk Assessment EDAT- 2024/08/21 17:42 MHDA- 2024/08/21 18:41 CRDT- 2024/08/21 11:34 PHST- 2024/08/21 18:41 [medline] PHST- 2024/08/21 17:42 [pubmed] PHST- 2024/08/21 11:34 [entrez] AID - 2822554 [pii] AID - 10.1001/jamanetworkopen.2024.29443 [doi] PST - epublish SO - JAMA Netw Open. 2024 Aug 1;7(8):e2429443. doi: 10.1001/jamanetworkopen.2024.29443. PMID- 37337089 OWN - NLM STAT- MEDLINE DCOM- 20230807 LR - 20230808 IS - 1476-5438 (Electronic) IS - 1018-4813 (Print) IS - 1018-4813 (Linking) VI - 31 IP - 8 DP - 2023 Aug TI - Preimplantation genetic testing for Neurofibromatosis type 1: more than 20 years of clinical experience. PG - 918-924 LID - 10.1038/s41431-023-01404-x [doi] AB - Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that affects the skin and the nervous system. The condition is completely penetrant with extreme clinical variability, resulting in unpredictable manifestations in affected offspring, complicating reproductive decision-making. One of the reproductive options to prevent the birth of affected offspring is preimplantation genetic testing (PGT). We performed a retrospective review of the medical files of all couples (n = 140) referred to the Dutch PGT expert center with the indication NF1 between January 1997 and January 2020. Of the couples considering PGT, 43 opted out and 15 were not eligible because of failure to identify the underlying genetic defect or unmet criteria for in vitro fertilization (IVF) treatment. The remaining 82 couples proceeded with PGT. Fertility assessment prior to IVF treatment showed a higher percentage of male infertility in males affected with NF1 compared to the partners of affected females. Cardiac evaluations in women with NF1 showed no contraindications for IVF treatment or pregnancy. For 67 couples, 143 PGT cycles were performed. Complications of IVF treatment were not more prevalent in affected females compared to partners of affected males. The transfer of 174 (out of 295) unaffected embryos led to 42 ongoing pregnancies with a pregnancy rate of 24.1% per embryo transfer. There are no documented cases of misdiagnosis following PGT in this cohort. With these results, we aim to provide an overview of PGT for NF1 with regard to success rate and safety, to optimize reproductive counseling and PGT treatment for NF1 patients. CI - © 2023. The Author(s). FAU - Vernimmen, Vivian AU - Vernimmen V AUID- ORCID: 0000-0001-9820-8958 AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. vivian.vernimmen@mumc.nl. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. vivian.vernimmen@mumc.nl. FAU - Paulussen, Aimée D C AU - Paulussen ADC AUID- ORCID: 0000-0002-1661-7625 AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Dreesen, Jos C F M AU - Dreesen JCFM AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - van Golde, Ron J AU - van Golde RJ AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Zamani Esteki, Masoud AU - Zamani Esteki M AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Coonen, Edith AU - Coonen E AUID- ORCID: 0000-0002-8601-7369 AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. AD - Department of Obstetrics and Gynecology, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - van Buul-van Zwet, Marianne L AU - van Buul-van Zwet ML AD - Department of Obstetrics and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Homminga, Irene AU - Homminga I AD - University of Groningen, University Medical Center Groningen, Department of Obstetrics and Gynecology, Section Reproductive Medicine, Groningen, The Netherlands. FAU - Derijck, Alwin A H A AU - Derijck AAHA AD - Amsterdam UMC location University of Amsterdam, Center for Reproductive Medicine, Amsterdam, The Netherlands. AD - Amsterdam Reproduction and Development, Preconception and Conception, Amsterdam, The Netherlands. FAU - Brandts, Lloyd AU - Brandts L AD - Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - Stumpel, Constance T R M AU - Stumpel CTRM AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. FAU - de Die-Smulders, Christine E M AU - de Die-Smulders CEM AD - GROW-School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands. AD - Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands. LA - eng PT - Journal Article DEP - 20230619 PL - England TA - Eur J Hum Genet JT - European journal of human genetics : EJHG JID - 9302235 SB - IM MH - Pregnancy MH - Humans MH - Male MH - Female MH - *Preimplantation Diagnosis/methods MH - *Neurofibromatosis 1/diagnosis/genetics MH - Genetic Testing/methods MH - Fertilization in Vitro MH - Embryo Transfer/psychology MH - Retrospective Studies MH - Aneuploidy PMC - PMC10400537 COIS- MZE is an inventor on patent application ZL913096-PCT/EP2014/068315-WO/2015/028576, ‘Haplotyping and copy-number typing using polymorphic variant allelic frequencies’. The other authors have no conflict of interest to disclose. EDAT- 2023/06/20 01:09 MHDA- 2023/08/07 06:42 PMCR- 2023/06/19 CRDT- 2023/06/19 23:27 PHST- 2023/02/23 00:00 [received] PHST- 2023/05/25 00:00 [accepted] PHST- 2023/05/16 00:00 [revised] PHST- 2023/08/07 06:42 [medline] PHST- 2023/06/20 01:09 [pubmed] PHST- 2023/06/19 23:27 [entrez] PHST- 2023/06/19 00:00 [pmc-release] AID - 10.1038/s41431-023-01404-x [pii] AID - 1404 [pii] AID - 10.1038/s41431-023-01404-x [doi] PST - ppublish SO - Eur J Hum Genet. 2023 Aug;31(8):918-924. doi: 10.1038/s41431-023-01404-x. Epub 2023 Jun 19. PMID- 35633085 OWN - NLM STAT- MEDLINE DCOM- 20230117 LR - 20230228 IS - 1365-2125 (Electronic) IS - 0306-5251 (Print) IS - 0306-5251 (Linking) VI - 89 IP - 2 DP - 2023 Feb TI - Acute appendicitis in a patient immunised with COVID-19 vaccine: A case report with morphological analysis. PG - 551-555 LID - 10.1111/bcp.15421 [doi] AB - Although the benefit/risk profile for mRNA COVID-19 vaccines is recognised as extremely favourable, appendicitis is currently considered an adverse event (AE) of special interest. We describe the case of a 58-year-old female who presented with signs and symptoms of appendicitis approximately 48 hours after her first injection of the Pfizer-BioNTech vaccine. Abdominal ultrasound revealed fluid collection in the right iliac fossa and cecal wall thickening. Following the surgical visit, CT scan with contrast showed a distended appendix with thickened walls, suggestive of acute appendicitis. The patient tested negative to upper respiratory COVID-19 reverse transcription-polymerase chain reaction. Clinical trials and observational studies suggest a possible association between appendicitis and COVID-19 vaccines. Th-1 driven granulomatous inflammation reported in our case represents an infrequent nonspecific chronic inflammation of the appendix, especially in the setting of delayed or interval appendectomy. In view of the current paediatric vaccination campaign, we recommend monitoring the safety profile and potential gastrointestinal AEs associated with mRNA COVID-19 vaccines to swiftly manage subjects with gastrointestinal symptoms and prevent potential complications. CI - © 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. FAU - Marconi, Ettore AU - Marconi E AD - Health Search, Italian College of General Practitioners and Primary Care, Florence, Italy. FAU - Crescioli, Giada AU - Crescioli G AD - Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. AD - Tuscan Regional Centre of Pharmacovigilance, Florence, Italy. FAU - Bonaiuti, Roberto AU - Bonaiuti R AD - Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. FAU - Pugliese, Lavinia AU - Pugliese L AD - Histopathology and Molecular Diagnostics, Careggi Teaching Hospital, Florence, Italy. FAU - Santi, Raffaella AU - Santi R AD - Pathology Section, Department of Health Sciences, University of Florence, Florence, Italy. FAU - Nesi, Gabriella AU - Nesi G AD - Pathology Section, Department of Health Sciences, University of Florence, Florence, Italy. FAU - Cerbai, Elisabetta AU - Cerbai E AD - Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. FAU - Vannacci, Alfredo AU - Vannacci A AUID- ORCID: 0000-0001-5259-2026 AD - Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. AD - Tuscan Regional Centre of Pharmacovigilance, Florence, Italy. FAU - Lombardi, Niccolò AU - Lombardi N AD - Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy. AD - Tuscan Regional Centre of Pharmacovigilance, Florence, Italy. LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220607 PL - England TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 RN - 0 (COVID-19 Vaccines) RN - 0 (RNA, Messenger) SB - IM MH - Humans MH - Child MH - Female MH - Middle Aged MH - *Appendicitis/complications/diagnosis/surgery MH - COVID-19 Vaccines/adverse effects MH - *COVID-19/diagnosis/prevention & control/complications MH - Inflammation MH - Acute Disease MH - RNA, Messenger PMC - PMC9348236 OTO - NOTNLM OT - COVID-19 OT - appendicitis OT - case report OT - histology OT - pharmacovigilance OT - vaccine COIS- All authors have no competing interests to disclose. EDAT- 2022/05/29 06:00 MHDA- 2023/01/18 06:00 PMCR- 2022/06/07 CRDT- 2022/05/28 03:02 PHST- 2022/05/05 00:00 [revised] PHST- 2022/03/31 00:00 [received] PHST- 2022/05/11 00:00 [accepted] PHST- 2022/05/29 06:00 [pubmed] PHST- 2023/01/18 06:00 [medline] PHST- 2022/05/28 03:02 [entrez] PHST- 2022/06/07 00:00 [pmc-release] AID - BCP15421 [pii] AID - 10.1111/bcp.15421 [doi] PST - ppublish SO - Br J Clin Pharmacol. 2023 Feb;89(2):551-555. doi: 10.1111/bcp.15421. Epub 2022 Jun 7. PMID- 29461615 OWN - NLM STAT- MEDLINE DCOM- 20191105 LR - 20191105 IS - 2284-0729 (Electronic) IS - 1128-3602 (Linking) VI - 22 IP - 3 DP - 2018 Feb TI - Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients. PG - 820-828 LID - 14318 [pii] LID - 10.26355/eurrev_201802_14318 [doi] AB - OBJECTIVE: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Here we analyzed the effect of 7 days treatment with 20 mg bilastine in patients with allergic rhinitis and/or chronic urticaria, on psychophysical performance assessed by the Formula One (F1) high-speed simulator-driving test. PATIENTS AND METHODS: This study is a phase IV, interventional, prospective, mono-centric, single arm, open-label trial. Eighteen outpatients affected by allergic rhinitis and/or chronic urticaria, able to perform a preliminary driving test on F1 simulator were considered (V-1). First, the patients had a screening visit to assess their eligibility (V0). Visit 1 (V1), at the end of placebo before bilastine treatment and Visit 2 (V2), at the end of bilastine treatment. The primary variable parameter was the ability to maintain the vehicle in a central position at different speeds (50, 150, and 250 km/h). RESULTS: Bilastine had a good safety profile and was well tolerated in terms of adverse events, laboratory parameters and vital signs. Bilastine did not have any negative effect on the ability to maintain the requested path, a constant speed as well as on attention and reactivity levels, even in extreme driving conditions. CONCLUSIONS: This study is the first done in patients with allergic rhinitis and/or chronic urticaria using a F1-high speed simulator-driving test evaluating subjects' performance under bilastine treatment. FAU - Demonte, A AU - Demonte A AD - Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine; Dermatology Unit; University of Modena and Reggio Emilia, Modena, Italy. patrizia.pepe@unimore.it. FAU - Guanti, M B AU - Guanti MB FAU - Liberati, S AU - Liberati S FAU - Biffi, A AU - Biffi A FAU - Fernando, F AU - Fernando F FAU - Fainello, M AU - Fainello M FAU - Pepe, P AU - Pepe P LA - eng PT - Clinical Trial, Phase IV PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Italy TA - Eur Rev Med Pharmacol Sci JT - European review for medical and pharmacological sciences JID - 9717360 RN - 0 (Benzimidazoles) RN - 0 (Histamine Antagonists) RN - 0 (Histamine H1 Antagonists, Non-Sedating) RN - 0 (Piperidines) RN - PA1123N395 (bilastine) SB - IM MH - Adult MH - Attention/drug effects/physiology MH - *Automobile Driving/psychology MH - Benzimidazoles/adverse effects/*therapeutic use MH - Chronic Disease MH - *Computer Simulation MH - Dizziness/chemically induced MH - Female MH - Histamine Antagonists/adverse effects/therapeutic use MH - Histamine H1 Antagonists, Non-Sedating/adverse effects/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Piperidines/adverse effects/*therapeutic use MH - Prospective Studies MH - Rhinitis, Allergic/*drug therapy/psychology MH - Urticaria/*drug therapy/psychology MH - Young Adult EDAT- 2018/02/21 06:00 MHDA- 2019/11/07 06:00 CRDT- 2018/02/21 06:00 PHST- 2018/02/21 06:00 [entrez] PHST- 2018/02/21 06:00 [pubmed] PHST- 2019/11/07 06:00 [medline] AID - 14318 [pii] AID - 10.26355/eurrev_201802_14318 [doi] PST - ppublish SO - Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):820-828. doi: 10.26355/eurrev_201802_14318. PMID- 32878575 OWN - NLM STAT- MEDLINE DCOM- 20201023 LR - 20201218 IS - 0036-9330 (Print) IS - 0036-9330 (Linking) VI - 65 IP - 4 DP - 2020 Nov TI - Role of immersive technologies in healthcare education during the COVID-19 epidemic. PG - 112-119 LID - 10.1177/0036933020956317 [doi] AB - The unparalleled epidemic of the novel coronavirus (COVID-19), during early December 2019 in Wuhan, China, has rapidly evolved into a global pandemic, became a matter of grave concern. The pandemic presented a unique challenge to government agencies worldwide. The paucity of resources and lack of knowledges to manage the pandemic, coupled with the fear of future consequences has established the need for adoption of emerging and future technologies to address the upcoming challenges. With introduction of measures to control the pandemic, trainees will see a dramatic decline in their in-person exposure to all aspects of their education, with no clear endpoint. This presents an extreme challenge for educators and, given the rapidly evolving situation, there have not yet been training authorities recommendations. We propose several innovative solutions to deliver medical education while maintaining the safety of residents and educators. FAU - Pears, Matthew AU - Pears M AD - Applied Cognition and Healthcare Researcher, School of Psychology, University of Leeds, UK. FAU - Yiasemidou, Marina AU - Yiasemidou M AUID- ORCID: 0000-0002-2599-4131 AD - NIHR Academic Clinical Lecturer in General Surgery, Hull York Medical School, ST6 Colorectal Surgery, Bradford Teaching Hospitals, Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, UK. FAU - Ismail, Mohamed A AU - Ismail MA AD - Medical student, Faculty of Medicine, University of Leeds, UK. FAU - Veneziano, Domenico AU - Veneziano D AD - Consultant Urologist, Department of Urology and Kidney Transplant, G.O.M. Reggio Calabria, Italy. FAU - Biyani, Chandra Shekhar AU - Biyani CS AUID- ORCID: 0000-0003-3443-8425 AD - Consultant Urologist, Department of Urology, St James's University Hospital, Leeds, UK. LA - eng PT - Journal Article DEP - 20200902 PL - Scotland TA - Scott Med J JT - Scottish medical journal JID - 2983335R SB - IM MH - *Betacoronavirus MH - COVID-19 MH - Communicable Disease Control MH - Coronavirus Infections/*epidemiology/prevention & control/transmission MH - Education, Medical/*organization & administration MH - *Educational Technology MH - Humans MH - Pandemics/prevention & control MH - Pneumonia, Viral/*epidemiology/prevention & control/transmission MH - SARS-CoV-2 OTO - NOTNLM OT - Simulation OT - emerging OT - non-technical skills OT - technical OT - technology EDAT- 2020/09/04 06:00 MHDA- 2020/10/24 06:00 CRDT- 2020/09/04 06:00 PHST- 2020/09/04 06:00 [pubmed] PHST- 2020/10/24 06:00 [medline] PHST- 2020/09/04 06:00 [entrez] AID - 10.1177/0036933020956317 [doi] PST - ppublish SO - Scott Med J. 2020 Nov;65(4):112-119. doi: 10.1177/0036933020956317. Epub 2020 Sep 2. PMID- 39647778 OWN - NLM STAT- Publisher LR - 20250212 IS - 2213-2961 (Electronic) IS - 2213-2961 (Linking) VI - 14 DP - 2024 Dec 6 TI - International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions. PG - 101014 LID - S2095-2546(24)00174-1 [pii] LID - 10.1016/j.jshs.2024.101014 [doi] AB - BACKGROUND: Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability. Handgrip strength (HGS) using isometric dynamometry is a convenient, feasible, and widely used method of assessing muscular strength among people of all ages. While adult HGS norms have been published for many countries, no study has yet synthesized available data to produce international norms. The objective of this study was to generate international sex- and age-specific norms for absolute and body size-normalized HGS across the adult lifespan. METHODS: Systematic searches were conducted in 6 databases/web search engines (MEDLINE, SPORTDiscus, Embase, Web of Science, CINAHL, and Google Scholar) up to December 1, 2023. We included full-text peer-reviewed observational studies that reported normative HGS data for adults aged ≥20 years by sex and age. Pseudo data were generated using Monte Carlo simulation following harmonization for methodological variation. Population-weighted Generalized Additive Models for Location, Scale, and Shape were used to develop sex- and age-specific norms for absolute HGS (kg) and HGS normalized by height (Ht, m) squared (i.e., HGS/Ht(2) in kg/m(2)). Norms were tabulated as percentile values (5th to 95th) and visualized as smoothed percentile curves. RESULTS: We included data from 100 unique observational studies representing 2,405,863 adults (51.9% female) aged 20 to 100+ years from 69 countries and regions tested from the year 2000 onward. On average, absolute and normalized HGS values negligibly improved throughout early adulthood, peaked from age 30-39 years (at 49.7 kg (males) and 29.7 kg (females) for absolute HGS or 16.3 kg/m(2) (males) and 11.3 kg/m(2) (females) for HGS/Ht(2)), and declined afterwards. The age-related decline in HGS accelerated from middle to late adulthood and was slightly larger for males than for females during middle adulthood. CONCLUSION: This study provides the world's largest and most geographically comprehensive international norms for adult HGS by sex and age. These norms have utility for global peer-comparisons, health screening, and surveillance. CI - Copyright © 2025. Production and hosting by Elsevier B.V. FAU - Tomkinson, Grant R AU - Tomkinson GR AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia. Electronic address: grant.tomkinson@unisa.edu.au. FAU - Lang, Justin J AU - Lang JJ AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia; Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON K1A 0K9, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. FAU - Rubín, Lukáš AU - Rubín L AD - Department of Physical Education and Sport, Faculty of Science, Humanities and Education, Technical University of Liberec, Liberec 461 17, Czech Republic; Institute of Active Lifestyle, Faculty of Physical Culture, Palacký University Olomouc, Olomouc 779 00, Czech Republic. FAU - McGrath, Ryan AU - McGrath R AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia; Healthy Aging North Dakota (HAND), North Dakota State University, Fargo, ND 58102, USA; Department of Health, Nutrition and Exercise Sciences, North Dakota State University, Fargo, ND 58108, USA; Fargo VA Healthcare System, Fargo, ND 58102, USA; Department of Geriatrics, University of North Dakota, Grand Forks, ND 58202, USA. FAU - Gower, Bethany AU - Gower B AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia. FAU - Boyle, Terry AU - Boyle T AD - Australian Centre for Precision Health, Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia. FAU - Klug, Marilyn G AU - Klug MG AD - Department of Population Health, University of North Dakota, Grand Forks, ND 58202, USA. FAU - Mayhew, Alexandra J AU - Mayhew AJ AD - Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Labarge Centre for Mobility in Aging, McMaster University, Hamilton, ON L8P 0A1, Canada; McMaster Institute for Research on Aging, McMaster University, Hamilton, ON L8P 0A1, Canada. FAU - Blake, Henry T AU - Blake HT AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia. FAU - Ortega, Francisco B AU - Ortega FB AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, ES 18071, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Granada, ES 18071, Spain; Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä 40014, Finland. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, ES 18071, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Granada, ES 18071, Spain; Department of Cardiology, Stanford University, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. FAU - Magnussen, Costan G AU - Magnussen CG AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia; Baker Heart and Diabetes Institute, Melbourne, VIC 3004, Australia; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku 20520, Finland. FAU - Fraser, Brooklyn J AU - Fraser BJ AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5000, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia. FAU - Kidokoro, Tetsuhiro AU - Kidokoro T AD - Faculty of Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan. FAU - Liu, Yang AU - Liu Y AD - School of Physical Education, Shanghai University of Sport, Shanghai 200438, China; Shanghai Research Center for Physical Fitness and Health of Children and Adolescents, Shanghai 200438, China. FAU - Christensen, Kaare AU - Christensen K AD - Department of Public Health, Epidemiology Biostatistics and Biodemography, University of Southern Denmark, Odense 5230, Denmark. FAU - Leong, Darryl P AU - Leong DP AD - The Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON L8L 2X2, Canada. CN - iGRIPS (international handGRIP Strength) Group LA - eng GR - P30 AR072581/AR/NIAMS NIH HHS/United States GR - MC_UU_00022/2/MRC_/Medical Research Council/United Kingdom GR - UL1 TR002529/TR/NCATS NIH HHS/United States GR - P30 AG012815/AG/NIA NIH HHS/United States GR - R01 AG017644/AG/NIA NIH HHS/United States GR - P01 AG005842/AG/NIA NIH HHS/United States GR - R01 AG052527/AG/NIA NIH HHS/United States GR - R01 AG042778/AG/NIA NIH HHS/United States GR - R21 AG025169/AG/NIA NIH HHS/United States PT - Journal Article PT - Review DEP - 20241206 PL - China TA - J Sport Health Sci JT - Journal of sport and health science JID - 101606001 SB - IM OTO - NOTNLM OT - Adult OT - Hand strength OT - Mass screening OT - Population health OT - Reference values FIR - Aadahl, Mette IR - Aadahl M IRAD- Centre for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. FIR - Abdin, Edimansyah IR - Abdin E IRAD- Research Division, Institute of Mental Health, Singapore. FIR - Alcazar, Julian IR - Alcazar J IRAD- GENUD Toledo Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha, Spain; Department of Geriatric and Palliative Medicine, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark; Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Spain; Grupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, IDISCAM, Spain. FIR - Alenazi, Aqeel IR - Alenazi A IRAD- Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia. FIR - Alqahtani, Bader IR - Alqahtani B IRAD- Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia. FIR - Amaral, Cledir De A IR - Amaral CA IRAD- Federal Institute of Acre, Brazil. FIR - Amaral, Thatiana L M IR - Amaral TLM IRAD- Federal University of Acre, Brazil. FIR - Fernandes, Alex Andrade IR - Fernandes AA IRAD- Instituto Federal de Educação, Ciência e Tecnologia de Minas Gerais-Campus Ipatinga, Brazil. FIR - Axelsson, Peter IR - Axelsson P IRAD- Department of Hand Surgery, Sahlgrenska University Hospital, Sweden; Department of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden. FIR - Baldwin, Jennifer N IR - Baldwin JN IRAD- Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Australia. FIR - Bammann, Karin IR - Bammann K IRAD- Institute for Public Health and Nursing Sciences, University of Bremen, Germany. FIR - Barbosa, Aline R IR - Barbosa AR IRAD- Centro de Desportos, Universidade Federal de Santa Catarina, Brazil. FIR - Bardo, Ameline IR - Bardo A IRAD- UMR 7194-HNHP, CNRS-MNHN, Département Homme et Environnement, Musée de l'Homme, Paris, France; Department of Human Origins, Max Planck Institute for Evolutionary Anthropology, Germany. FIR - Bimali, Inosha IR - Bimali I IRAD- Department of Physiotherapy, Kathmandu University School of Medical Sciences, Nepal. FIR - Bjerregaard, Peter IR - Bjerregaard P IRAD- National Institute of Public Health, University of Southern Denmark, Denmark. FIR - Bobak, Martin IR - Bobak M IRAD- International Institute for Health and Society, Department of Epidemiology and Public Health, University College London, UK. FIR - Boreham, Colin A IR - Boreham CA IRAD- Institute for Sport and Health, University College Dublin, Ireland. FIR - Bös, Klaus IR - Bös K IRAD- Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Germany. FIR - Marins, João Carlos Bouzas IR - Marins JCB IRAD- Physical Education Department, Federal University of Viçosa, Brazil. FIR - Burns, Joshua IR - Burns J IRAD- Disability Prevention Program, St. Jude Children's Research Hospital, USA. FIR - Capkova, Nadezda IR - Capkova N IRAD- Environmental and Population Health Monitoring Centre, National Institute of Public Health, Czech Republic. FIR - Castillo-Martínez, Lilia IR - Castillo-Martínez L IRAD- Clinical Nutrition Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico. FIR - Chen, Liang-Kung IR - Chen LK IRAD- Center for Geriatrics and Gerontology, Taipei Veterans General Hospital; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University; Taipei Municipal Gan-Dau Hospital. FIR - Choi, Siu Ming IR - Choi SM IRAD- Faculty of Education, University of Macau, Macao, China. FIR - Choong, Rebecca K J IR - Choong RKJ IRAD- Department of Medicine, Universiti Malaya Medical Centre, Malaysia. FIR - Confortin, Susana C IR - Confortin SC IRAD- Postgraduate Program in Public Health (PPGSCol), University of the Extreme South of Santa Catarina (UNESC), Brazil. FIR - Cooper, Cyrus IR - Cooper C IRAD- MRC Lifecourse Epidemiology Centre, University of Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK; NIHR Oxford Biomedical Research Centre, University of Oxford, UK. FIR - Correa-Bautista, Jorge E IR - Correa-Bautista JE IRAD- Facultad de Ciencias del Deporte y la Educación Física, Universidad de Cundinamarca, Colombia. FIR - Cournil, Amandine IR - Cournil A IRAD- Mission pour la Science Ouverte, Institut de Recherche pour le Développement, France. FIR - Cruz, Grace IR - Cruz G IRAD- Population Institute, University of the Philippines, Philippines. FIR - de Bruin, Eling D IR - de Bruin ED IRAD- Institute of Human Movement Sciences and Sport (IBWS), Department of Health Sciences and Technology, ETH Zurich, Switzerland; OST-Eastern Swiss University of Applied Sciences, Department of Health, Switzerland; Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Sweden. FIR - De Paz, José Antonio IR - De Paz JA IRAD- Institute of Biomedicine, University of León, Spain; Division of Biological Sciences and Health, University of Sonora, Mexico. FIR - Moreira, Bruno De Souza IR - Moreira BS IRAD- Center for Studies in Public Health and Aging-Federal University of Minas Gerais and Oswaldo Cruz Foundation-Minas Gerais, Brazil. FIR - Anjos, Luiz Antonio Dos IR - Anjos LAD IRAD- Departamento de Nutrição Social, Faculdade de Nutrição Emilia de Jesus Ferreiro, Universidade Federal Fluminense (UFF), Brazil. FIR - Reyna, María Cristina Enríquez IR - Reyna MCE IRAD- Universidad Autónoma de Nuevo León, Facultad de Organización Deportiva Monterrey, Mexico. FIR - Ferriolli, Eduardo IR - Ferriolli E IRAD- Department of Internal Medicine, Ribeirao Preto Medical School, University of São Paulo, Brazil. FIR - Forrester, Gillian IR - Forrester G IRAD- School of Psychology, University of Sussex, UK. FIR - Frolova, Elena IR - Frolova E IRAD- The North-Western State Medical University named after I.I. Mechnikov, Russia. FIR - Gebre, Abadi K IR - Gebre AK IRAD- Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Australia; School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. FIR - Ghaleb, Atef M IR - Ghaleb AM IRAD- Department of Industrial Engineering, College of Engineering, Alfaisal University, Saudi Arabia. FIR - Gill, Tiffany K IR - Gill TK IRAD- Adelaide Medical School, The University of Adelaide, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Australia. FIR - Gondo, Yasuyuki IR - Gondo Y IRAD- Facultad de Ciencias del Deporte y la Educación Física, Universidad de Cundinamarca, Colombia; Graduate School of Human Sciences, Osaka University, Japan. FIR - Gonzalez, M Cristina IR - Gonzalez MC IRAD- Postgraduate Program in Nutrition and Food, Federal University of Pelotas, Brazil; Pennington Biomedical Research Center, USA. FIR - Alvarez, Citlali Gonzalez IR - Alvarez CG IRAD- Escuela Nacional de Antropologia e Historia, Instituto Nacional de Antropologia e Historia, Mexico. FIR - Hannah, Mary K IR - Hannah MK IRAD- MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, UK. FIR - Harvey, Nicholas C IR - Harvey NC IRAD- MRC Lifecourse Epidemiology Centre, University of Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, UK. FIR - Hogrel, Jean-Yves IR - Hogrel JY IRAD- Neuromuscular Investigation Center, Institute of Myology, France. FIR - Huemer, Marie-Theres IR - Huemer MT IRAD- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Germany. FIR - Iidaka, Toshiko IR - Iidaka T IRAD- Department of Preventive Medicine for Locomotive Organ Disorders, 22(nd) Century Medical and Research Center, The University of Tokyo, Japan. FIR - Ingram, Lewis A IR - Ingram LA IRAD- Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Australia. FIR - Jdanov, Dmitri A IR - Jdanov DA IRAD- Max Planck Institute for Demographic Research, Germany; National Research University Higher School of Economics, Russia. FIR - Keevil, Victoria L IR - Keevil VL IRAD- Department of Medicine, University of Cambridge, UK. FIR - Kemmler, Wolfgang IR - Kemmler W IRAD- Institute of Radiology, University-Hospital Erlangen, Germany; Institute of Medical Physics, University of Erlangen-Nürnberg, Germany. FIR - Kenny, Rose Anne IR - Kenny RA IRAD- The Irish Longitudinal Study on Ageing (TILDA), School of Medicine, Trinity College Dublin, Ireland. FIR - Kim, Dae-Yeon IR - Kim DY IRAD- Measurement and Evaluation in Physical Education and Sport Science, Korea National Sport University, Republic of Korea. FIR - Kivell, Tracy L IR - Kivell TL IRAD- Department of Human Origins, Max Planck Institute for Evolutionary Anthropology, Germany. FIR - Kjær, Ingirid G H IR - Kjær IGH IRAD- Department of Sport Science and Physical Education, The University of Agder, Norway. FIR - Kluttig, Alexander IR - Kluttig A IRAD- Institute of Medical Epidemiology, Biometrics and Informatics, Interdisciplinary Center for Health Sciences, Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Germany. FIR - Kozakai, Rumi IR - Kozakai R IRAD- Department of Health and Welfare Science, School of Lifelong Sport, Hokusho University, Japan; Department of Epidemiology of Aging, Research Institute, National Center for Geriatrics and Gerontology, Japan. FIR - Langer, Danit IR - Langer D IRAD- School of Occupational Therapy, Faculty of Medicine, Hebrew University, Israel. FIR - Larsen, Lisbeth A IR - Larsen LA IRAD- Department of Public Health, Epidemiology, Biostatistics and Biodemography, University of Southern Denmark, Denmark. FIR - Lee, Wei-Ju IR - Lee WJ IRAD- Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University; Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch. FIR - Leon, David A IR - Leon DA IRAD- Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, UK. FIR - Lichtenstein, Eric IR - Lichtenstein E IRAD- Department of Sport, Exercise and Health, University of Basel, Switzerland. FIR - Little, Bertis B IR - Little BB IRAD- School of Public Health and Information Sciences, University of Louisville, USA. FIR - Lourenço, Roberto Alves IR - Lourenço RA IRAD- Research Laboratory on Human Aging-GeronLab, Internal Medicine Department, Faculty of Medical Sciences, State University of Rio de Janeiro, Brazil; Department of Medicine, Pontifical Catholic University, Brazil. FIR - Malhotra, Rahul IR - Malhotra R IRAD- Centre for Ageing Research and Education, Duke-National University of Singapore Medical School, Singapore; Health Services and Systems Research, Duke-National University of Singapore Medical School, Singapore. FIR - Malina, Robert M IR - Malina RM IRAD- Department of Kinesiology and Health Education, University of Texas, USA; School of Public Health and Information Sciences, University of Louisville, USA. FIR - Matsumoto, Kiyoaki IR - Matsumoto K IRAD- Graduate School of Human Sciences, Osaka University, Japan. FIR - Mazor-Karsenty, Tal IR - Mazor-Karsenty T IRAD- School of Occupational Therapy, Faculty of Medicine, Hebrew University, Israel. FIR - McKay, Marnee J IR - McKay MJ IRAD- Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Australia. FIR - McLoughlin, Sinéad IR - McLoughlin S IRAD- The Irish Longitudinal Study on Ageing (TILDA), Trinity Central, Trinity College Dublin, Ireland. FIR - Mensegere, Abhishek L IR - Mensegere AL IRAD- Centre for Brain Research, Indian Institute of Science, India. FIR - Mohammadian, Mostafa IR - Mohammadian M IRAD- Health Foresight and Innovation Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Iran. FIR - Moreira, Virgilio Garcia IR - Moreira VG IRAD- Research Laboratory on Human Aging-GeronLab, Internal Medicine Department, Faculty of Medical Sciences, State University of Rio de Janeiro, Brazil. FIR - Murayama, Hiroshi IR - Murayama H IRAD- Tokyo Metropolitan Institute for Geriatrics and Gerontology (TMIG), Japan. FIR - Murray, Anne IR - Murray A IRAD- Berman Centre for Outcomes and Clinical Research, Hennepin Healthcare Research Institute, USA; University of Minnesota, USA. FIR - Neri, Anita Liberalesso IR - Neri AL IRAD- Department of Educational Psychology, Faculty of Education, State University of Campinas, Brazil. FIR - Niessner, Claudia IR - Niessner C IRAD- Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Germany. FIR - Othón, Gabriel Núñez IR - Othón GN IRAD- Division of Biological Sciences and Health, University of Sonora, Mexico. FIR - Olveira, Gabriel IR - Olveira G IRAD- Servicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Spain; IBIMA/plataforma Bionand, Spain; Departamento de Medicina y Dermatología, Universidad de Málaga, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain. FIR - Orchard, Suzanne G IR - Orchard SG IRAD- School of Public Health and Preventive Medicine, Monash University, Australia. FIR - Pajak, Andrezj IR - Pajak A IRAD- Department of Epidemiology and Population Studies, Jagellonian University Collegium Medicum, Poland. FIR - Park, Chan Woong IR - Park CW IRAD- Department of Kinesiology, College of Health & Human Services, Sacramento State University, USA. FIR - Pasco, Julie A IR - Pasco JA IRAD- Deakin University, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Australia; Department of Medicine-Western Health, The University of Melbourne, Australia. FIR - Reyes, Maria E Peña IR - Reyes MEP IRAD- Escuela Nacional de Antropologia e Historia, Instituto Nacional de Antropologia e Historia, Mexico. FIR - Pereira, Leani Souza Máximo IR - Pereira LSM IRAD- Postgraduate program in Health Sciences at the Faculty of Medical Sciences of Minas Gerais, Brazil. FIR - Peters, Annette IR - Peters A IRAD- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Germany; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Germany. FIR - Poon, Eric Tsz-Chun IR - Poon ET IRAD- Department of Sports Science and Physical Education, The Chinese University of Hong Kong, Hong Kong, China. FIR - Portela, Margareth C IR - Portela MC IRAD- Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Brazil. FIR - Pratt, Jedd IR - Pratt J IRAD- Institute for Sport and Health, University College Dublin, Ireland; Department of Sport and Exercise Sciences, Manchester Metropolitan University Institute of Sport, UK. FIR - Ramírez-Vélez, Robinson IR - Ramírez-Vélez R IRAD- Navarrabiomed, Hospital Universitario de Navarra (HUN)-Universidad Pública de Navarra (UPNA), IdiSNA, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Spain. FIR - Rodríguez-García, Wendy IR - Rodríguez-García W IRAD- Licenciatura en Nutriología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, Mexico. FIR - Ryan, Joanne IR - Ryan J IRAD- School of Public Health and Preventive Medicine, Monash University, Australia. FIR - San-Martín, Mauricio A IR - San-Martín MA IRAD- Locomotor Apparatus and Rehabilitation Institute, Faculty of Medicine, Universidad Austral de Chile, Chile. FIR - Sánchez-Torralvo, Francisco José IR - Sánchez-Torralvo FJ IRAD- Servicio de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Spain; IBIMA/plataforma Bionand, Spain. FIR - Saremi, Mahnaz IR - Saremi M IRAD- Workplace Health Promotion Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Iran. FIR - Schmidt-Trucksäss, Arno IR - Schmidt-Trucksäss A IRAD- Department of Sport, Exercise and Health, University of Basel, Switzerland. FIR - Seino, Satoshi IR - Seino S IRAD- Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan. FIR - Shah, Shamsul Azhar IR - Shah SA IRAD- Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Malaysia. FIR - Sim, Marc IR - Sim M IRAD- Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Australia; Medical School, The University Western Australia, Australia. FIR - Strand, Bjørn Heine IR - Strand BH IRAD- Department of Physical Health and Ageing, Norwegian Institute of Public Health, Norway. FIR - Subramaniam, Mythily IR - Subramaniam M IRAD- Research Division, Institute of Mental Health, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. FIR - Suetta, Charlotte IR - Suetta C IRAD- Department of Geriatric and Palliative Medicine, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark; Department of Clinical Medicine, Faculty of Health, University of Copenhagen, Denmark. FIR - Sui, Sophia X IR - Sui SX IRAD- Deakin University, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Australia. FIR - Sundarakumar, Jonas S IR - Sundarakumar JS IRAD- Centre for Brain Research, Indian Institute of Science, India. FIR - Suzuki, Koya IR - Suzuki K IRAD- Graduate School of Health and Sports Science, Juntendo University, Japan. FIR - Tamosiunas, Abdonas IR - Tamosiunas A IRAD- Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Lithuania. FIR - Tan, Maw Pin IR - Tan MP IRAD- Division of Geriatric Medicine, Department of Medicine, Universiti Malaya, Malaysia. FIR - Taniguchi, Yu IR - Taniguchi Y IRAD- Tokyo Metropolitan Institute of Gerontology, Japan. FIR - Thorand, Barbara IR - Thorand B IRAD- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Germany; Institute for Medical Information Processing, Biometry and Epidemiology (IBE), Faculty of Medicine, LMU Munich, Pettenkofer School of Public Health, Germany. FIR - Turusheva, Anna IR - Turusheva A IRAD- The North-Western State Medical University named after I.I. Mechnikov, Russia. FIR - Tveter, Anne Therese IR - Tveter AT IRAD- Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Health Service Research and Innovation Unit, Diakonhjemmet Hospital, Norway; Department of Rehabilitation Science and Health Technology, Institute of Health Sciences, Oslo Metropolitan University, Norway. FIR - Wagner, Jonathan IR - Wagner J IRAD- Department of Sport, Exercise and Health, University of Basel, Switzerland. FIR - Wang, Dao IR - Wang D IRAD- Physical Fitness Research and Health Guidance Center, Shanghai Research Institute of Sports Science (Shanghai Anti-Doping Agency), China. FIR - Warden, Stuart J IR - Warden SJ IRAD- Department of Physical Therapy, School of Health and Human Sciences, Indiana University Indianapolis, USA. FIR - Wearing, Julia IR - Wearing J IRAD- School for Interprofessional Health Care, Cooperative State University Baden-Wuerttemberg, Germany. FIR - Wee, Shiou Liang IR - Wee SL IRAD- Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore; Geriatric Education and Research Institute, Singapore. FIR - Westbury, Leo D IR - Westbury LD IRAD- MRC Lifecourse Epidemiology Centre, University of Southampton, UK. FIR - Wiśniowska-Szurlej, Agnieszka IR - Wiśniowska-Szurlej A IRAD- Institute of Health Sciences, Medical College of Rzeszow University, Poland. FIR - Woll, Alexander IR - Woll A IRAD- Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Germany. FIR - Yoshimura, Noriko IR - Yoshimura N IRAD- Department of Preventive Medicine for Locomotive Organ Disorders, 22(nd) Century Medical and Research Center, The University of Tokyo, Japan. FIR - Yu, Ruby IR - Yu R IRAD- Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; CUHK Jockey Club Institute of Ageing, The Chinese University of Hong Kong, Hong Kong, China. EDAT- 2024/12/09 00:22 MHDA- 2024/12/09 00:22 CRDT- 2024/12/08 19:17 PHST- 2024/07/15 00:00 [received] PHST- 2024/09/23 00:00 [revised] PHST- 2024/10/08 00:00 [accepted] PHST- 2024/12/09 00:22 [pubmed] PHST- 2024/12/09 00:22 [medline] PHST- 2024/12/08 19:17 [entrez] AID - S2095-2546(24)00174-1 [pii] AID - 10.1016/j.jshs.2024.101014 [doi] PST - aheadofprint SO - J Sport Health Sci. 2024 Dec 6;14:101014. doi: 10.1016/j.jshs.2024.101014. PMID- 24077493 OWN - NLM STAT- MEDLINE DCOM- 20141001 LR - 20190923 IS - 1882-6482 (Electronic) IS - 0021-5082 (Linking) VI - 68 IP - 3 DP - 2013 TI - [Economic damage caused by lowered prices in the agro-food sector in areas contaminated by radioactive materials leaked from the nuclear power plant severely damaged by the 2011 Great East Japan Earthquake--consideration from the viewpoints of epidemiology, economics and social psychology]. PG - 207-14 AB - INTRODUCTION: Large amounts of radioactive materials were leaked into the environment from the Fukushima Daiichi Nuclear Power Plant (FDNPP) of the Tokyo Electric Power Company, which was severely damaged by the 2011 Tohoku Region Pacific Coast Earthquake and accompanying tsunami. Economic damage due to lowered prices and supplies of food products produced in the areas contaminated by the radioactive materials leaked from the damaged FDNPP to the agro-food sector in the affected areas is notable. In Japanese, this is known as fuhyo higai. In this study, we investigated fuhyo higai from the viewpoints of epidemiology, economics, and social psychology in an effort to seek solutions. METHOD: Information was obtained from articles in print and on the Internet. RESULTS AND DISCUSSION: Fuhyo higai, or economic damage of the agro-food sector, which is the main industry in the contaminated areas, is serious because it is difficult to reassure the general population regarding food safety. This fuhyo higai does not derive solely from rumor. It has been reported that improving the science literacy of the general population is important as a countermeasure against fuhyo higai, but this may not be effective because of the human social structure and behavior of people who seek subjective safety. Almost all radiological laboratory results of samples of food produced in the contaminated areas were below detectable limits. Very high values were rarely detected. In general, information about the dose-response relationship is obtained under the assumption that there may be error in the response but not in the dose. The rare cases of extremely high radiological values of food samples from the contaminated areas may correspond to large errors in dose. However, it is difficult to deny a high-dose risk. The reported information on the dose-response relationship obtained under the assumption that there is no error in dose is not sufficient. Thus, response, i.e., health risk, cannot be correctly estimated. This leads the general population to choose food products from areas far from the FDNPP over those from the contaminated areas. In order to resolve this problem, thorough decontamination of radioactive areas, including large forests, is necessary for the market to regain competitiveness to the level it was before the accident. The cost of such decontamination is enormous and requires much labor. Decontamination will create employment and is indispensable in restoring the deteriorated economic conditions of the affected areas. FAU - Sugita, Minoru AU - Sugita M AD - Toho University. FAU - Miyakawa, Michiko AU - Miyakawa M LA - jpn PT - English Abstract PT - Journal Article PT - Review PL - Japan TA - Nihon Eiseigaku Zasshi JT - Nihon eiseigaku zasshi. Japanese journal of hygiene JID - 0417457 RN - 0 (Radioactive Pollutants) SB - IM MH - *Earthquakes MH - *Food MH - *Fukushima Nuclear Accident MH - Humans MH - Japan MH - Psychology, Social/*economics MH - Radioactive Pollutants/adverse effects/*economics MH - Risk EDAT- 2013/10/01 06:00 MHDA- 2014/10/02 06:00 CRDT- 2013/10/01 06:00 PHST- 2013/10/01 06:00 [entrez] PHST- 2013/10/01 06:00 [pubmed] PHST- 2014/10/02 06:00 [medline] AID - DN/JST.JSTAGE/jjh/68.207 [pii] AID - 10.1265/jjh.68.207 [doi] PST - ppublish SO - Nihon Eiseigaku Zasshi. 2013;68(3):207-14. doi: 10.1265/jjh.68.207. PMID- 32198965 OWN - NLM STAT- MEDLINE DCOM- 20210217 LR - 20210217 IS - 1365-2834 (Electronic) IS - 0966-0429 (Linking) VI - 28 IP - 4 DP - 2020 May TI - Nurses' work characteristics and self-assessment of the work environment-Explorative cross-sectional study. PG - 860-871 LID - 10.1111/jonm.13010 [doi] AB - AIM: The aim of the study was to explore the characteristics of nursing work and the correlation with the conditions in nurses' work environment. BACKGROUND: Although the correlation between nurses' work characteristics and the safety of health care provision has been confirmed, nurses continue to work in discouraging environments. METHOD: A cross-sectional study was conducted. A total of 1,744 nurses from 16 Slovenian hospitals participated. Variables included the following: work characteristics, ergonomic conditions at work, the prevalence of low back pain and self-assessment of conditions in the work environment. RESULTS: One nurse was responsible for 17.90 patients per shift (SD = 13.615), shifts were understaffed in 42.9% of cases, and technical assistive devices were available in 30% of cases. Job demands were explained with number of patients/shift (p < .001), job satisfaction (p < .001), availability of assistive devices (p = .001) and the female gender (p = .001). Decision authority was low and explained with a non-leadership position (p < .001), educational achievement (p < .001), dissatisfaction with the job (p < .001) and the male gender (p = .008). CONCLUSION: A safe patient-to-nurse ratio, job satisfaction, availability of assistive devices and fostering decision authority turned out to be important in our study. IMPLICATIONS FOR NURSING MANAGEMENT: Europe is facing an increasing shortage of nurses, so actions for reducing nurse overload and encouraging decision authority are extremely important both for nurses and for patients. Participative leadership and ensuring gender equality in nursing are vital. CI - © 2020 John Wiley & Sons Ltd. FAU - Skela-Savič, Brigita AU - Skela-Savič B AD - Angela Boškin Faculty of Health Care, Angela Boškin Institute for Research in Healthcare Sciences, Jesenice, Slovenia. FAU - Dobnik, Mojca AU - Dobnik M AUID- ORCID: 0000-0001-7848-9086 AD - University Medical Centre Maribor, Maribor, Slovenia. FAU - Kalender-Smajlović, Sedina AU - Kalender-Smajlović S AUID- ORCID: 0000-0003-4472-7044 AD - Angela Boškin Faculty of Health Care, Jesenice, Slovenia. LA - eng GR - 0142-3/2014-DI/477/Health Insurance Institute of Slovenia/ PT - Journal Article DEP - 20200420 PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 MH - Adult MH - Cross-Sectional Studies MH - Female MH - Humans MH - Job Satisfaction MH - Male MH - Middle Aged MH - *Organizational Culture MH - *Self-Assessment MH - Slovenia MH - Surveys and Questionnaires MH - Work/*classification/standards MH - Workplace/psychology/standards EDAT- 2020/03/22 06:00 MHDA- 2021/02/18 06:00 CRDT- 2020/03/22 06:00 PHST- 2019/12/10 00:00 [received] PHST- 2020/03/11 00:00 [revised] PHST- 2020/03/14 00:00 [accepted] PHST- 2020/03/22 06:00 [pubmed] PHST- 2021/02/18 06:00 [medline] PHST- 2020/03/22 06:00 [entrez] AID - 10.1111/jonm.13010 [doi] PST - ppublish SO - J Nurs Manag. 2020 May;28(4):860-871. doi: 10.1111/jonm.13010. Epub 2020 Apr 20. PMID- 33314249 OWN - NLM STAT- MEDLINE DCOM- 20211004 LR - 20211004 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 54 IP - 3 DP - 2021 Mar TI - Disordered eating behaviors and sexual objectification during New York fashion week: Implementation of industry policies and legislation. PG - 433-437 LID - 10.1002/eat.23432 [doi] AB - OBJECTIVE: The working conditions of professional fashion models may place them at risk for negative outcomes including disordered eating. New policies in the United States and France, including providing private changing areas and requiring medical certificates, have been implemented to protect models from pressures to be extremely thin and sexual harassment. This study evaluated the implementation of the new policies during the week of New York Fashion Week, February 2018 (NYFW Fall'18). METHOD: A sample of 76 fashion models (87% female) aged over 18 years who had participated in NYFW Fall'18 completed an online survey, reporting on behaviors and experiences occurring during NYFW Fall'18. RESULTS: A large proportion of respondents reported unhealthy weight control behaviors, including skipping meals (54%), intravenous drips (39%), and self-induced vomiting (25%). Fewer than half reported being always or sometimes provided with a private changing area, with 45% reporting experiencing lack of privacy when changing. A subset (n = 15) had obtained a health certificate for events in Paris. Most health providers had assessed weight, but few assessed eating and exercise behaviors. DISCUSSION: Policy interventions to improve health and safety of models are not yet achieving intended goals and require continued monitoring. CI - © 2020 Wiley Periodicals LLC. FAU - Rodgers, Rachel F AU - Rodgers RF AUID- ORCID: 0000-0002-2582-4220 AD - APPEAR, Department of Applied Psychology, Northeastern University, Boston, Massachusetts, USA. AD - Department of Psychiatric Emergency & Acute Care, Lapeyronie Hospital, CHRU, Montpellier, France. FAU - Ziff, Sara AU - Ziff S AD - Model Alliance, New York, New York City, USA. FAU - Lowy, Alice S AU - Lowy AS AD - APPEAR, Department of Applied Psychology, Northeastern University, Boston, Massachusetts, USA. FAU - Austin, S Bryn AU - Austin SB AUID- ORCID: 0000-0002-0830-5293 AD - Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. LA - eng GR - T71-MC-00009/Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services./ GR - T76-MC-00001/Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services./ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. DEP - 20201212 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Adult MH - *Feeding and Eating Disorders/diagnosis MH - Female MH - Health Behavior MH - Humans MH - Male MH - Middle Aged MH - New York MH - Policy MH - Sexual Behavior MH - United States OTO - NOTNLM OT - appearance pressure OT - eating disorders OT - fashion models OT - fashion week OT - legislation OT - policy OT - sexual objectification OT - thin ideal OT - unhealthy weight control behaviors EDAT- 2020/12/15 06:00 MHDA- 2021/10/05 06:00 CRDT- 2020/12/14 11:08 PHST- 2020/11/04 00:00 [revised] PHST- 2020/07/16 00:00 [received] PHST- 2020/11/06 00:00 [accepted] PHST- 2020/12/15 06:00 [pubmed] PHST- 2021/10/05 06:00 [medline] PHST- 2020/12/14 11:08 [entrez] AID - 10.1002/eat.23432 [doi] PST - ppublish SO - Int J Eat Disord. 2021 Mar;54(3):433-437. doi: 10.1002/eat.23432. Epub 2020 Dec 12. PMID- 36175130 OWN - NLM STAT- MEDLINE DCOM- 20230206 LR - 20230206 IS - 1449-8944 (Electronic) IS - 0156-5788 (Linking) VI - 47 IP - 1 DP - 2023 Feb TI - Worsening general health and psychosocial wellbeing of Australian hospital allied health practitioners during the COVID-19 pandemic. PG - 124-130 LID - 10.1071/AH22110 [doi] AB - Objective To describe self-reported general and psychological health for allied health practitioners at an Australian acute public health service over three time points within the coronavirus disease 2019 (COVID-19) pandemic. Methods This study collected data from cross-sectional online surveys at three time points: May-June 2020 (T 1 ), October-November 2020 (T 2 ) and November-December 2021 (T 3 ). The self-report questionnaire consisted of demographic questions, a general health question and the 21-item version of the Depression Anxiety Stress Scales (DASS-21). Results A total of 308 responses were received (T 1 n  = 135, T 2 n  = 78, T 3 n  = 95) from representatives of eight allied health professions. The proportion of allied health practitioners reporting poor general health significantly increased over time, as did mean scores on all DASS-21 sub-scales. General health status was also significantly associated with DASS-21 subscale scores. Anxiety scores increased significantly between T 1 and T 2 , while depression scores increased significantly between T 2 and T 3 . Significant increases in stress scores were recorded across all time intervals. Between T 1 and T 3 , the proportion of allied health practitioners reporting moderate, severe, or extremely severe symptoms increased for depression (10.3-30.9%), anxiety (5.2-18.2%) and stress (13.3-36.3%). Conclusion The general and psychological health of allied health practitioners appears to be worsening as the COVID-19 pandemic continues. Organisational strategies to support the health of the allied health workforce in acute care settings must address the cumulative effects of prolonged pressure on their general and psychosocial health. Support strategies need to be responsive to changes in psychological wellbeing at different phases of the pandemic. FAU - Hitch, Danielle AU - Hitch D AD - Allied Health, Western Health, St. Albans, Vic., Australia; and Occupational Science and Therapy, Deakin University, Geelong, Vic., Australia; and Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. FAU - Booth, Sarah AU - Booth S AD - Allied Health, Western Health, St. Albans, Vic., Australia. FAU - Wynter, Karen AU - Wynter K AD - Nursing and Midwifery, Deakin University, Burwood, Vic., Australia; and Centre of Quality and Patient Safety Research in the Institute for Health Transformation - Western Health Partnership, Deakin University, Burwood, Vic., Australia. FAU - Said, Catherine M AU - Said CM AD - Allied Health, Western Health, St. Albans, Vic., Australia; and Physiotherapy, Melbourne School of Health Sciences, The University of Melbourne, Parkville, Vic., Australia; and Australian Institute of Musculoskeletal Science, St. Albans, Vic., Australia. FAU - Haines, Kimberley AU - Haines K AD - Allied Health, Western Health, St. Albans, Vic., Australia. FAU - Rasmussen, Bodil AU - Rasmussen B AD - Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Nursing and Midwifery, Deakin University, Burwood, Vic., Australia; and Centre of Quality and Patient Safety Research in the Institute for Health Transformation - Western Health Partnership, Deakin University, Burwood, Vic., Australia; and Faculty of Health Services, University of Southern Denmark, Odense M, Denmark. FAU - Holton, Sara AU - Holton S AD - Nursing and Midwifery, Deakin University, Burwood, Vic., Australia; and Centre of Quality and Patient Safety Research in the Institute for Health Transformation - Western Health Partnership, Deakin University, Burwood, Vic., Australia. LA - eng PT - Journal Article PL - Australia TA - Aust Health Rev JT - Australian health review : a publication of the Australian Hospital Association JID - 8214381 MH - Humans MH - *COVID-19 MH - Pandemics MH - Cross-Sectional Studies MH - SARS-CoV-2 MH - Depression/epidemiology/psychology MH - Australia/epidemiology MH - Surveys and Questionnaires MH - Health Status EDAT- 2022/09/30 06:00 MHDA- 2023/02/07 06:00 CRDT- 2022/09/29 21:40 PHST- 2022/05/04 00:00 [received] PHST- 2022/09/02 00:00 [accepted] PHST- 2022/09/30 06:00 [pubmed] PHST- 2023/02/07 06:00 [medline] PHST- 2022/09/29 21:40 [entrez] AID - AH22110 [pii] AID - 10.1071/AH22110 [doi] PST - ppublish SO - Aust Health Rev. 2023 Feb;47(1):124-130. doi: 10.1071/AH22110. PMID- 39511917 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20241108 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 18 DP - 2024 Nov 8 TI - Urgent Warning: Evidence-Based Concerns Regarding Mass Gathering Events During Arbaeen in Hazardous Weather Conditions. PG - e258 LID - 10.1017/dmp.2024.173 [doi] AB - The Arbaeen ceremony is the largest annual mass gathering in the world, attracting millions of Muslim pilgrims each year. However, the event takes place during the summer in Iraq, coinciding with extreme heat and dust storms. Climate change hazards, such as heat waves and dust storms, can have destructive effects on human health, leading to increased mortality and the spread of various diseases. This manuscript recommends measures to stakeholders in emergency or public health management to develop a preventive plan for the Arbaeen ceremony. These measures include improving planning and risk assessment, enhancing capacities, reducing vulnerabilities, increasing knowledge and awareness among pilgrims, developing communication and support systems, ensuring compliance with safety protocols, and regularly assessing evacuation routes. Implementing these measures will contribute to ensuring the safety and well-being of participants during the Arbaeen ceremony in the years ahead. FAU - Aghababaeian, Hamidreza AU - Aghababaeian H AUID- ORCID: 0000-0003-3339-5507 AD - Department of Health in Emergencies and Disasters, Dezful University of Medical Sciences, Dezful, Iran. AD - Center for Climate Change and Health Research (CCCHR), Dezful University of Medical Sciences, Dezful, Iran. AD - Universal Scientific Education and Research Network (USERN), Dezful University of Medical Sciences, Dezful, Iran. FAU - Etedali, Hooman AU - Etedali H AD - Center for Climate Change and Health Research (CCCHR), Dezful University of Medical Sciences, Dezful, Iran. AD - Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran. LA - eng PT - Journal Article DEP - 20241108 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Humans MH - Iraq MH - *Weather MH - Climate Change/statistics & numerical data MH - Islam/psychology MH - Disaster Planning/methods MH - Mass Behavior MH - Crowding OTO - NOTNLM OT - climate change OT - disasters OT - emergencies OT - health OT - mass gathering EDAT- 2024/11/13 13:51 MHDA- 2024/11/14 03:54 CRDT- 2024/11/08 02:03 PHST- 2024/11/14 03:54 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/08 02:03 [entrez] AID - S1935789324001733 [pii] AID - 10.1017/dmp.2024.173 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2024 Nov 8;18:e258. doi: 10.1017/dmp.2024.173. PMID- 38450457 OWN - NLM STAT- MEDLINE DCOM- 20240308 LR - 20240308 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 18 DP - 2024 Mar 7 TI - Public Perception Toward the Malaysian National COVID-19 Immunisation Programme (PICK) in the State of Sabah, Malaysia: A Cross-Sectional Survey. PG - e43 LID - 10.1017/dmp.2024.31 [doi] AB - The Malaysian Government has initiated the National COVID-19 Immunisation Programme, known as PICK, to be a national strategy for addressing the spread of the coronavirus disease (COVID-19) pandemic across the country. Although the government intensified public awareness to increase program registration, the total number that registered in the state of Sabah, located in East Malaysia, was relatively low during August 2021, accounting for only 42.9% as compared to that of Peninsular Malaysia. Therefore, this paper examines the public perception toward the PICK program in Sabah based on 4 main components: safety, communication, psychology, and milieu. This study is based on the empirical findings drawn from 1024 respondents across Sabah using online Google Form surveys. This study adopts 5 methodologies for data analysis by using K-means clustering, mean score, Mann-Whitney U test, spatial analysis, and frequency analysis. It has been revealed that the percentage of respondents (categorized as Cluster 1) who have a negative perception toward the vaccination program is higher (55.9%) than those who have a positive perception (44.1%). This study further discovered that Cluster 1 has shown high skepticism regarding the vaccination program, which can be explained through the communication component (M = 3.33, SD = 0.588), especially Co2, Co3, Co1, and Co4. Following the communication factor, a chain of negative perceptions also affects other components such as safety, psychology, and milieu among Cluster 1, all of which contribute to poor participation in the PICK program. The study outcomes are extremely useful for informing local authorities to establish policies related to public interests, primarily in the areas of public health. Understanding the community's perspectives and their obstacles in participating in such programs may assist local authorities in developing or implementing public policies and campaigns that ensure such related public programs can be conducted more effectively in the future. FAU - Jafar, Adi AU - Jafar A AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Dollah, Ramli AU - Dollah R AUID- ORCID: 0000-0001-8683-8848 AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Sakke, Nordin AU - Sakke N AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Mapa, Mohammad Tahir AU - Mapa MT AUID- ORCID: 0000-0003-3396-2559 AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Atang, Colonius AU - Atang C AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Joko, Eko Prayitno AU - Joko EP AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Sarjono, Fauzie AU - Sarjono F AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Zakaria, Noor Syakirah AU - Zakaria NS AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - George, Fionna AU - George F AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. FAU - Vun Hung, Chong AU - Vun Hung C AD - Faculty of Social Sciences and Humanities, Universiti Malaysia Sabah (UMS), Kota Kinabalu, Sabah, 88400, Malaysia. LA - eng PT - Journal Article DEP - 20240307 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Humans MH - Malaysia MH - Cross-Sectional Studies MH - *Public Opinion MH - *COVID-19/epidemiology/prevention & control MH - Immunization Programs OTO - NOTNLM OT - Malaysia OT - communication OT - public health OT - vaccination program OT - vaccine hesitancy EDAT- 2024/03/07 06:42 MHDA- 2024/03/08 06:42 CRDT- 2024/03/07 04:43 PHST- 2024/03/08 06:42 [medline] PHST- 2024/03/07 06:42 [pubmed] PHST- 2024/03/07 04:43 [entrez] AID - S1935789324000314 [pii] AID - 10.1017/dmp.2024.31 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2024 Mar 7;18:e43. doi: 10.1017/dmp.2024.31. PMID- 16126609 OWN - NLM STAT- MEDLINE DCOM- 20060103 LR - 20221207 IS - 1067-3229 (Print) IS - 1067-3229 (Linking) VI - 13 IP - 4 DP - 2005 Jul-Aug TI - When mothers leave their children behind. PG - 233-43 AB - Psychiatry has studied the effect on children of separation from their mothers or primary caregivers, but has not given equal attention to the effect on mothers of separation from their children. This article examines the current literature on separation from the mother's perspective. Following a review of the literature on mothers' attachment behaviors, as evidenced by separation from their very young children due to ordinary circumstances, attention will turn to specific populations of mothers enduring separation from their children in situations of hardship: mothers with mental illness, homeless mothers, mothers in prison, and two groups of working mothers-immigrant mothers and deployed navy mothers. Separation can be experienced as temporary, bringing on anxiety, or may involve a mother's choice between her child's safety and her own wish to keep the child near her, causing a conflict in the mother's feelings. In other situations, separation may be involuntary and long-lasting, inducing symptoms of depression, despair, and grief, all of which are characteristic of loss. The particular conditions of the separation-such as choice, control, and ongoing communication between mother and child-can mitigate the impact of the separation and transform it from a total to a partial loss. Three clinical cases of mothers forced to separate from their children in extreme circumstances are examined, with recommendations for treatment. FAU - Schen, Cathy R AU - Schen CR AD - Department of Psychiatry, Harvard Medical School; Cambridge Health Alliance, Cambridge, MA 02139, USA. cschen@hms.harvard.edu LA - eng PT - Journal Article PL - United States TA - Harv Rev Psychiatry JT - Harvard review of psychiatry JID - 9312789 SB - IM MH - Anxiety, Separation/psychology MH - Child MH - Child, Preschool MH - Female MH - Grief MH - Ill-Housed Persons/psychology MH - Humans MH - Infant MH - *Mother-Child Relations MH - Mothers/*psychology MH - *Object Attachment MH - Prisoners/psychology MH - Psychotic Disorders/*psychology MH - Warfare MH - Women, Working/psychology EDAT- 2005/08/30 09:00 MHDA- 2006/01/04 09:00 CRDT- 2005/08/30 09:00 PHST- 2005/08/30 09:00 [pubmed] PHST- 2006/01/04 09:00 [medline] PHST- 2005/08/30 09:00 [entrez] AID - P26442683144Q170 [pii] AID - 10.1080/10673220500243380 [doi] PST - ppublish SO - Harv Rev Psychiatry. 2005 Jul-Aug;13(4):233-43. doi: 10.1080/10673220500243380. PMID- 39546978 OWN - NLM STAT- MEDLINE DCOM- 20241125 LR - 20241227 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 265 DP - 2024 Dec 1 TI - Revisiting the alcohol-aggression link: The impact of alcohol consumption patterns. PG - 112496 LID - S0376-8716(24)01421-2 [pii] LID - 10.1016/j.drugalcdep.2024.112496 [doi] AB - Laboratory studies have repeatedly reported a link between alcohol and aggression, yet many rely on single-dose administration methods and overlook variations in alcohol consumption patterns. The present study investigates the effects of alcohol on aggressive behavior using a double-blind, placebo-controlled cumulative drinking administration approach that mirrors the natural drinking behaviors often observed in pubs within a laboratory setting. This study also pioneers the examination of how alcohol consumption patterns (light or heavy) moderate the relationship between precise Breath Alcohol Concentration (BrAC) levels and extreme aggressive behavior. Seventy-five individuals who drink alcohol lightly (N=38) and heavily (N=37) were randomly assigned to alcohol (N=33) or placebo (N=42) conditions. Participants drank four drinks successively. Taylor's aggression paradigm was completed twenty minutes after each drink. Multilevel modeling was applied to analyze the effects of precise BrAC and account for within-person variability. Alcohol showed a dose-dependent effect on aggression; as alcohol levels rose, so did aggression (p<.001). Alcohol consumption pattern moderated the effect of cumulative BrAC on aggression, such that the effect was more substantial for as compared with individuals who drink lightly (p=.03). The current study highlights the moderating role of alcohol consumption pattern in the association between precise BrAC levels and extreme aggression, offering insights into individual differences in susceptibility to alcohol-induced aggression, and supporting the I(3) meta-theory (Finkel, 2014). The Findings underscore the importance of investigating the interplay between acute and chronic alcohol use on behavior, challenging conventional thresholds for hazardous drinking classification. Implications for future studies, legislators, and policymakers are discussed. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Nagar, Maayan AU - Nagar M AD - Department of Criminology, Ariel University, Ariel, Israel; Criminology Department, Bar Ilan University, Ramat-Gan, Israel. Electronic address: maayanbn@ariel.ac.il. FAU - Rabinovitz, Sharon AU - Rabinovitz S AD - School of Criminology, Faculty of Law, University of Haifa, Haifa, Israel; The Unit and The Laboratory for Excellence in Research & Study of Addiction (ERSA) and The Center for the Study of Crime, Law, and Society, University of Haifa, Israel. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20241108 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 RN - 3K9958V90M (Ethanol) SB - IM MH - Humans MH - *Aggression/drug effects/psychology MH - Male MH - *Alcohol Drinking/psychology MH - Female MH - Double-Blind Method MH - Young Adult MH - Adult MH - *Ethanol/administration & dosage/pharmacology MH - *Breath Tests MH - Adolescent OTO - NOTNLM OT - Acute effects, I(3) meta-theory, Alcohol consumption pattern OT - Aggression OT - Alcohol OT - Cumulative dosing procedure COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Sharon Rabinovitz reports financial support was provided by the Israel National Authority for Community Safety, Ministry of Public Security. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/11/16 09:57 MHDA- 2024/11/26 00:16 CRDT- 2024/11/15 18:08 PHST- 2024/08/05 00:00 [received] PHST- 2024/10/27 00:00 [revised] PHST- 2024/10/29 00:00 [accepted] PHST- 2024/11/26 00:16 [medline] PHST- 2024/11/16 09:57 [pubmed] PHST- 2024/11/15 18:08 [entrez] AID - S0376-8716(24)01421-2 [pii] AID - 10.1016/j.drugalcdep.2024.112496 [doi] PST - ppublish SO - Drug Alcohol Depend. 2024 Dec 1;265:112496. doi: 10.1016/j.drugalcdep.2024.112496. Epub 2024 Nov 8. PMID- 24315883 OWN - NLM STAT- MEDLINE DCOM- 20140811 LR - 20220317 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 32 IP - 5 DP - 2014 Jan 23 TI - Parent and provider perspectives on immunization: are providers overestimating parental concerns? PG - 579-84 LID - S0264-410X(13)01665-4 [pii] LID - 10.1016/j.vaccine.2013.11.076 [doi] AB - OBJECTIVES: Data are limited on whether providers understand parental attitudes to recommended childhood immunizations. We determined parental attitudes and assessed how accurately providers estimated parental opinions. METHODS: Survey of parents and providers (pediatricians, nurses, medical assistants) in randomly selected practices in Houston, Texas. Surveys assessed demographics, perceptions of immunization importance, safety and efficacy, and acceptability of vaccine delivery. Providers estimated parental responses. RESULTS: 401 parents (82% mothers, 12% fathers, 6% other) and 105 providers participated. Parents thought vaccines were important for health (median score 9.5; 0=not important, 10=extremely important) but also were concerned regarding vaccine safety and side effects (8.9 on 0-10 scale). 309 (77%) agreed that vaccines effectively prevent disease. Route of administration mattered to 147 (37%), who preferred injection (9.0) over oral (7.3) or intranasal (4.8) routes. Although parents would prefer three or fewer injections per visit, preventing more diseases (189 [47.6%]) was more important than number of injections (167 [42.3%]) when deciding the number of vaccines allowed per visit. White parents rated vaccines less important in preventing some illnesses than did non-white (P≤0.006 for meningitis, hepatitis, HPV, influenza and rotavirus) and rated number of injections per visit more important than number of diseases prevented (51.6% white versus 34.2% non-white; P 0.002). Providers underestimated parental attitudes toward vaccine importance (particularly influenza and HPV), and overestimated the proportion of parents who thought route of administration mattered (63%) and that number of injections per visit was the most important factor (76%) around parental vaccine decisions (P<0.001 for parent-provider mismatch). CONCLUSIONS: Most surveyed parents believe vaccines are important for child health and rate disease prevention higher than number of injections entailed. Providers underestimate the importance of some vaccines to parents and overestimate parental concerns regarding route of administration. Future research should focus on how this mismatch impacts parental vaccine decisions. CI - Copyright © 2013 Elsevier Ltd. All rights reserved. FAU - Healy, C Mary AU - Healy CM AD - Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Center for Vaccine Awareness and Research, Texas Children's Hospital, 1102 Bates St., Suite 1120, Houston, TX 77030, USA. Electronic address: chealy@bcm.edu. FAU - Montesinos, Diana P AU - Montesinos DP AD - Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA; Center for Vaccine Awareness and Research, Texas Children's Hospital, 1102 Bates St., Suite 1120, Houston, TX 77030, USA. FAU - Middleman, Amy B AU - Middleman AB AD - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131204 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Vaccines) SB - IM MH - Adult MH - Decision Making MH - Female MH - Health Care Surveys MH - *Health Knowledge, Attitudes, Practice MH - *Health Personnel MH - Humans MH - Immunization/*psychology MH - Male MH - Middle Aged MH - Parents/*psychology MH - Texas MH - Vaccines/administration & dosage MH - Young Adult OTO - NOTNLM OT - CDC OT - CHIP OT - Centers for Disease Control and Prevention OT - Children's Health Insurance Program OT - HPV OT - Haemophilus influenzae type b OT - Hib OT - Immunization OT - MA OT - Parent provider mismatch OT - Parental beliefs OT - Provider estimates OT - VPD OT - Vaccine hesitancy OT - human papillomavirus OT - medical assistant OT - vaccine-preventable disease EDAT- 2013/12/10 06:00 MHDA- 2014/08/12 06:00 CRDT- 2013/12/10 06:00 PHST- 2013/08/26 00:00 [received] PHST- 2013/10/25 00:00 [revised] PHST- 2013/11/21 00:00 [accepted] PHST- 2013/12/10 06:00 [entrez] PHST- 2013/12/10 06:00 [pubmed] PHST- 2014/08/12 06:00 [medline] AID - S0264-410X(13)01665-4 [pii] AID - 10.1016/j.vaccine.2013.11.076 [doi] PST - ppublish SO - Vaccine. 2014 Jan 23;32(5):579-84. doi: 10.1016/j.vaccine.2013.11.076. Epub 2013 Dec 4. PMID- 35775959 OWN - NLM STAT- MEDLINE DCOM- 20221004 LR - 20221009 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 58 IP - 10 DP - 2022 Oct TI - Parental perceptions on the impact of visiting restrictions during COVID-19 in a tertiary neonatal intensive care unit. PG - 1747-1752 LID - 10.1111/jpc.16079 [doi] AB - AIM: During the first wave of coronavirus disease 2019 (COVID-19), visiting guidelines in neonatal units changed to maintain the health and safety of staff, neonates, and families. In the neonatal intensive care unit/special care nursery (NICU/SCN), restrictions were placed on parental contact and extended family excluded. Our team was interested in evaluating the effect of these restrictions on parental stress and discharge confidence. METHODS: A prospective descriptive study utilising survey methodology was undertaken. The survey was developed and previously used by the NICU research group to evaluate parental knowledge and understanding, parental role, communication, and parental stress (admission/discharge). We have also included a section regarding COVID19 visiting restrictions (ETH.2020.LRE.00124). The survey used a five-level Likert scale. Statistical analysis was completed using SPSS version 21. RESULTS: Notably, 33 surveys were returned. Results showed visiting restrictions reduced social contact between partners 26/33 (84%), with their other children 14/16 (87.5%) and extended family 28/33 (84.8%). Parents indicated that they had high levels of confidence in understanding their babies' medical needs (78-93%) and gaining hands-on experience caring for their baby (87-100%). However, 11/33 (33%) of parents reported concerns with discharge processes and gaining consistent information as challenges during their baby's admission. Notably, 17/33 (51.5) stated their NICU/SCN experience had been very to extremely stressful. Parents openly described how the restrictions had affected their mental/emotional health identifying the need to treat parents as one unit, and a gap in the psychological support available for families. CONCLUSION: Support services and consistency of communication with NICU/SCN families need to be enhanced and prioritised during periods of restrictions, especially peri-discharge. CI - © 2022 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Broom, Margaret AU - Broom M AUID- ORCID: 0000-0001-8118-366X AD - Centenary Hospital for Women and Children, Canberra Hospital, Canberra, Australian Capital Territory, Australia. AD - SYNERGY: Nursing and Midwifery Research Centre, University of Canberra and ACT Health, Canberra, Australian Capital Territory, Australia. FAU - Cochrane, Tim AU - Cochrane T AD - Centenary Hospital for Women and Children, Canberra Hospital, Canberra, Australian Capital Territory, Australia. AD - College of Health and Medicine, Australian National University Medical School, Canberra, Australian Capital Territory, Australia. FAU - Cruickshank, Debbora AU - Cruickshank D AD - Centenary Hospital for Women and Children, Canberra Hospital, Canberra, Australian Capital Territory, Australia. FAU - Carlisle, Hazel AU - Carlisle H AD - Centenary Hospital for Women and Children, Canberra Hospital, Canberra, Australian Capital Territory, Australia. AD - College of Health and Medicine, Australian National University Medical School, Canberra, Australian Capital Territory, Australia. LA - eng PT - Journal Article DEP - 20220701 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - *COVID-19 MH - Child MH - Communication MH - Humans MH - Infant MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - Parents/psychology MH - Patient Discharge PMC - PMC9350120 OTO - NOTNLM OT - COVID-19 OT - developmental OT - intensive care OT - neonatology OT - parent EDAT- 2022/07/02 06:00 MHDA- 2022/10/05 06:00 PMCR- 2022/07/01 CRDT- 2022/07/01 09:42 PHST- 2022/02/14 00:00 [revised] PHST- 2021/11/04 00:00 [received] PHST- 2022/06/06 00:00 [accepted] PHST- 2022/07/02 06:00 [pubmed] PHST- 2022/10/05 06:00 [medline] PHST- 2022/07/01 09:42 [entrez] PHST- 2022/07/01 00:00 [pmc-release] AID - JPC16079 [pii] AID - 10.1111/jpc.16079 [doi] PST - ppublish SO - J Paediatr Child Health. 2022 Oct;58(10):1747-1752. doi: 10.1111/jpc.16079. Epub 2022 Jul 1. PMID- 39192830 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20241212 IS - 1744-7593 (Electronic) IS - 1742-5247 (Linking) VI - 21 IP - 12 DP - 2024 Dec TI - Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals. PG - 1879-1888 LID - 10.1080/17425247.2024.2394112 [doi] AB - BACKGROUND: Cyltezo® (Adalimumab-adbm) is an FDA-approved interchangeable biosimilar for Humira® (adalimumab reference product [RP]) that helps treat chronic inflammatory conditions. Adalimumab-adbm is administered via an autoinjector, the adalimumab-adbm pen. This study assessed user opinions related to usability, perceptions, convenience, safety features, and acceptability of the adalimumab-adbm pen. METHODS: Ninety-eight Humira Pen users, 100 biologics pen naïve patients, and 99 healthcare professionals simulated the use of the adalimumab-adbm pen on injection pads. Opinions were captured with a validated questionnaire using Likert-type scales during moderated interviews. Binomial tests were conducted for top-two rating percentages. RESULTS: Nearly 90% of participants found the adalimumab-adbm pen 'easy' or 'very easy' to use, handle, and learn how to use. Almost 90% of volunteers thought the pen was 'very' or 'extremely' solid and convenient to use at home. Around 80% found the pen to be 'very' or 'extremely' comfortable. Over 90% of respondents said they would be 'satisfied' or 'very satisfied' with the safety features and the device itself. Nearly 90% of respondents indicated being 'very' or 'extremely' open to adopting the adalimumab-adbm pen. CONCLUSIONS: The adalimumab-adbm pen provided users with a positive experience with features that benefit perceptions of usability, handling, safety, convenience, and acceptability. FAU - Perez, Raul AU - Perez R AD - Noble International LLC, Orlando, FL, USA. FAU - Suman, Julie D AU - Suman JD AD - AptarGroup Inc, Congers, NY, USA. FAU - Reynolds, Joe AU - Reynolds J AD - Noble International LLC, Orlando, FL, USA. LA - eng PT - Journal Article DEP - 20241121 PL - England TA - Expert Opin Drug Deliv JT - Expert opinion on drug delivery JID - 101228421 RN - FYS6T7F842 (Adalimumab) RN - 0 (Biosimilar Pharmaceuticals) RN - 0 (Anti-Inflammatory Agents) SB - IM MH - Humans MH - *Adalimumab/administration & dosage MH - Adult MH - Male MH - Female MH - Middle Aged MH - Surveys and Questionnaires MH - *Biosimilar Pharmaceuticals/administration & dosage MH - Anti-Inflammatory Agents/administration & dosage MH - Young Adult MH - Health Personnel/psychology MH - Aged MH - Patient Acceptance of Health Care MH - Self Administration MH - Injections OTO - NOTNLM OT - Subcutaneous drug delivery OT - autoinjector OT - autoinjector user experience OT - drug delivery device OT - patient Experience OT - patient acceptability EDAT- 2024/08/28 08:42 MHDA- 2024/12/12 12:27 CRDT- 2024/08/28 04:02 PHST- 2024/12/12 12:27 [medline] PHST- 2024/08/28 08:42 [pubmed] PHST- 2024/08/28 04:02 [entrez] AID - 10.1080/17425247.2024.2394112 [doi] PST - ppublish SO - Expert Opin Drug Deliv. 2024 Dec;21(12):1879-1888. doi: 10.1080/17425247.2024.2394112. Epub 2024 Nov 21. PMID- 37559437 OWN - NLM STAT- MEDLINE DCOM- 20240319 LR - 20240716 IS - 1758-5341 (Electronic) IS - 0016-9013 (Linking) VI - 64 IP - 4 DP - 2024 Apr 1 TI - The Experiences of Skilled Nursing Staff in Memory Care Units During the COVID-19 Pandemic. LID - gnad108 [pii] LID - 10.1093/geront/gnad108 [doi] AB - BACKGROUND AND OBJECTIVES: The novel coronavirus disease 2019 (COVID-19) resulted in the need for multiple mitigation strategies. The impacts of these safety measures were felt more extremely by healthcare providers. This qualitative study focused on the experiences of staff in skilled nursing facilities, specifically in locked memory care units, during the first year of the COVID-19 pandemic. RESEARCH DESIGN AND METHODS: This study used a basic interpretive methodology. In-depth interviews were conducted with skilled nursing staff members who worked in a locked memory care unit during the 2020 calendar year. Thematic analysis was used to organize and interpret the data. RESULTS: A total of 11 participants provided data that resulted in themes around reasons for working on a locked memory care unit, experiences working with people who have behavioral and psychological symptoms due to dementia, training, outcomes of shared experiences, outcomes of policy changes, management support, and suggestions for a future pandemic. DISCUSSION AND IMPLICATIONS: The results of this study may have implications for skilled nursing facilities with locked memory care units that continue to grapple with the realities of providing care during a pandemic. Providing appropriate training, social support, and appropriate protective equipment are among the suggestions. CI - © The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Holmes, Patricia AU - Holmes P AUID- ORCID: 0000-0002-2050-9141 AD - Department of Interprofessional Health and Aging Studies, University of Indianapolis, Indianapolis, Indiana, USA. FAU - Santurri, Laura AU - Santurri L AD - Department of Interprofessional Health and Aging Studies, University of Indianapolis, Indianapolis, Indiana, USA. FAU - Ewen, Heidi H AU - Ewen HH AUID- ORCID: 0000-0002-4215-6551 AD - Department of Interprofessional Health and Aging Studies, University of Indianapolis, Indianapolis, Indiana, USA. FAU - Baggett, Sharron AU - Baggett S AD - Independent Researcher, Portland, Oregon, USA. LA - eng PT - Journal Article PL - United States TA - Gerontologist JT - The Gerontologist JID - 0375327 SB - IM MH - Humans MH - Nursing Homes MH - *COVID-19/epidemiology MH - Pandemics MH - *Dementia/psychology MH - *Nursing Staff MH - Qualitative Research OTO - NOTNLM OT - caregiver support OT - dementia OT - nursing care EDAT- 2023/08/10 06:43 MHDA- 2024/03/19 06:44 CRDT- 2023/08/10 02:14 PHST- 2023/03/29 00:00 [received] PHST- 2024/03/19 06:44 [medline] PHST- 2023/08/10 06:43 [pubmed] PHST- 2023/08/10 02:14 [entrez] AID - 7240175 [pii] AID - 10.1093/geront/gnad108 [doi] PST - ppublish SO - Gerontologist. 2024 Apr 1;64(4):gnad108. doi: 10.1093/geront/gnad108. PMID- 33903603 OWN - NLM STAT- MEDLINE DCOM- 20210510 LR - 20240401 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 11 IP - 1 DP - 2021 Apr 26 TI - Dual impacts of coronavirus anxiety on mental health in 35 societies. PG - 8925 LID - 10.1038/s41598-021-87771-1 [doi] LID - 8925 AB - The spread of coronavirus disease 2019 (COVID-19) has affected both physical health and mental well-being around the world. Stress-related reactions, if prolonged, may result in mental health problems. We examined the consequences of the COVID-19 pandemic on mental health in a multinational study and explored the effects of government responses to the outbreak. We sampled 18,171 community adults from 35 countries/societies, stratified by age, gender, and region of residence. Across the 35 societies, 26.6% of participants reported moderate to extremely severe depression symptoms, 28.2% moderate to extremely severe anxiety symptoms, and 18.3% moderate to extremely severe stress symptoms. Coronavirus anxiety comprises two factors, namely Perceived Vulnerability and Threat Response. After controlling for age, gender, and education level, perceived vulnerability predicted higher levels of negative emotional symptoms and psychological distress, whereas threat response predicted higher levels of self-rated health and subjective well-being. People in societies with more stringent control policies had more threat response and reported better subjective health. Coronavirus anxiety exerts detrimental effects on subjective health and well-being, but also has the adaptive function in mobilizing safety behaviors, providing support for an evolutionary perspective on psychological adaptation. FAU - Chen, Sylvia Xiaohua AU - Chen SX AD - The Hong Kong Polytechnic University, Hong Kong, China. ssxhchen@polyu.edu.hk. AD - Department of Applied Social Sciences, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. ssxhchen@polyu.edu.hk. FAU - Ng, Jacky C K AU - Ng JCK AD - Hong Kong Shue Yan University, Hong Kong, China. FAU - Hui, Bryant P H AU - Hui BPH AD - The Hong Kong Polytechnic University, Hong Kong, China. FAU - Au, Algae K Y AU - Au AKY AD - The Hong Kong Polytechnic University, Hong Kong, China. FAU - Wu, Wesley C H AU - Wu WCH AD - The Hong Kong Polytechnic University, Hong Kong, China. FAU - Lam, Ben C P AU - Lam BCP AD - The University of New South Wales, Sydney, Australia. FAU - Mak, Winnie W S AU - Mak WWS AD - The Chinese University of Hong Kong, Hong Kong, China. FAU - Liu, James H AU - Liu JH AD - Massey University, Auckland, New Zealand. LA - eng GR - 1-ZE1L/Project of Strategic Importance, Hong Kong Polytechnic University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210426 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Adaptation, Psychological MH - Adult MH - Aged MH - Aged, 80 and over MH - Anxiety/*etiology MH - COVID-19/epidemiology/*psychology/virology MH - Disease Outbreaks MH - Female MH - Humans MH - Internationality MH - Male MH - *Mental Health MH - Middle Aged MH - Pandemics MH - SARS-CoV-2/isolation & purification MH - Severity of Illness Index MH - Young Adult PMC - PMC8076265 COIS- The authors declare no competing interests. EDAT- 2021/04/28 06:00 MHDA- 2021/05/11 06:00 PMCR- 2021/04/26 CRDT- 2021/04/27 06:26 PHST- 2020/10/25 00:00 [received] PHST- 2021/03/30 00:00 [accepted] PHST- 2021/04/27 06:26 [entrez] PHST- 2021/04/28 06:00 [pubmed] PHST- 2021/05/11 06:00 [medline] PHST- 2021/04/26 00:00 [pmc-release] AID - 10.1038/s41598-021-87771-1 [pii] AID - 87771 [pii] AID - 10.1038/s41598-021-87771-1 [doi] PST - epublish SO - Sci Rep. 2021 Apr 26;11(1):8925. doi: 10.1038/s41598-021-87771-1. PMID- 36992786 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230331 IS - 2673-6616 (Electronic) IS - 2673-6616 (Linking) VI - 3 DP - 2022 TI - "It Just Kind of Feels Like a Different World Now:" Stress and Resilience for Adolescents With Type 1 Diabetes in the Era of COVID-19. PG - 835739 LID - 10.3389/fcdhc.2022.835739 [doi] LID - 835739 AB - PURPOSE: The COVID-19 pandemic has been a major stressor for adolescents. Given the unique implications of the pandemic for youth with type 1 diabetes (T1D), who already navigate multiple stressors as a function of their chronic condition, we aimed to describe the impact of the pandemic on adolescents with T1D and describe their coping strategies and resilience resources. RESEARCH METHOD: In a 2-site (Seattle WA, Houston TX) clinical trial of a psychosocial intervention targeting stress/resilience, adolescents 13-18 years old with T1D ≥ 1 year and elevated diabetes distress were enrolled August 2020 - June 2021. Participants completed a baseline survey about the pandemic, including open-ended questions about the effects of the pandemic, what was helping them navigate, and how it impacted T1D management. Hemoglobin A1c (A1c) was extracted from clinical records. Free text responses were analyzed using an inductive content approach. Survey responses and A1c were summarized using descriptive statistics and associations were assessed by Chi-squared tests. RESULTS: Adolescents (n=122) were 56% female. 11% of adolescents reported diagnosis of COVID-19 and 12% had a family member/other important person die from COVID-19 complications. Adolescents described Social Relationships, Personal Health/Safety Practices, Mental Health, Family Relationships, and School to be primary areas affected by COVID-19. Helpful resources included: Learned Skills/Behaviors, Social Support/Community, and Meaning-Making/Faith. Among participants indicating that the pandemic had an impact on their T1D management (n=35), the most commonly described areas were: Food, Self-Care, Health/Safety, Diabetes Appointments, and Exercise. Compared to adolescents who reported minimal difficulty managing T1D during the pandemic (71%), those reporting moderate to extreme difficulty (29%) were more likely to have A1C ≥ 8% (80% vs. 43%, p<.01). CONCLUSIONS: Results underscore the pervasive impact of COVID-19 on teens with T1D across multiple major life domains. Their coping strategies aligned with stress, coping, and resilience theories and suggest resilient responses in the face of stress. Despite experiencing pandemic-related stressors in many areas, diabetes-related functioning was relatively protected for most teens, highlighting their diabetes-specific resilience. Discussing the pandemic impact on T1D management may be an important focus for clinicians, especially for adolescents with diabetes distress and above-target A1C. CI - Copyright © 2022 O’Donnell, Hilliard, Cao, Bradford, Barton, Hurtado, Duran, Perez, Rahman, Scott, Malik, DeSalvo, Pihoker, Zhou, Rosenberg and Yi-Frazier. FAU - O'Donnell, Maeve B AU - O'Donnell MB AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. AD - Department of Pediatrics, Division of Diabetes/Endocrinology, University of Washington School of Medicine, Seattle, WA, United States. AD - Cambia Palliative Care Center of Excellence, University of Washington School of Medicine, Seattle, WA, United States. FAU - Hilliard, Marisa E AU - Hilliard ME AD - Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, United States. FAU - Cao, Viena T AU - Cao VT AD - Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, United States. FAU - Bradford, Miranda C AU - Bradford MC AD - Core for Biostatistics, Epidemiology and Analytics for Research (BEAR) Core, Seattle Children's Research Institute, Seattle, WA, United States. FAU - Barton, Krysta S AU - Barton KS AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. AD - Core for Biostatistics, Epidemiology and Analytics for Research (BEAR) Core, Seattle Children's Research Institute, Seattle, WA, United States. FAU - Hurtado, Samantha AU - Hurtado S AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. FAU - Duran, Brenda AU - Duran B AD - Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, United States. FAU - Perez, Samantha Garcia AU - Perez SG AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. FAU - Rahman, Kiswa S AU - Rahman KS AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. FAU - Scott, Samantha AU - Scott S AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. AD - Department of Psychology, University of Denver, Denver, CO, United States. FAU - Malik, Faisal S AU - Malik FS AD - Department of Pediatrics, Division of Diabetes/Endocrinology, University of Washington School of Medicine, Seattle, WA, United States. AD - Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, United States. FAU - DeSalvo, Daniel J AU - DeSalvo DJ AD - Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, United States. FAU - Pihoker, Catherine AU - Pihoker C AD - Department of Pediatrics, Division of Diabetes/Endocrinology, University of Washington School of Medicine, Seattle, WA, United States. FAU - Zhou, Chuan AU - Zhou C AD - Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA, United States. AD - Department of Pediatrics, Division of General Pediatrics, School of Medicine, University of Washington, Seattle, WA, United States. FAU - Rosenberg, Abby R AU - Rosenberg AR AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. AD - Cambia Palliative Care Center of Excellence, University of Washington School of Medicine, Seattle, WA, United States. FAU - Yi-Frazier, Joyce P AU - Yi-Frazier JP AD - Palliative Care and Resilience Lab, Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, United States. LA - eng PT - Journal Article DEP - 20220221 PL - Switzerland TA - Front Clin Diabetes Healthc JT - Frontiers in clinical diabetes and healthcare JID - 9918266295306676 PMC - PMC10012077 OTO - NOTNLM OT - COVID-19 OT - diabetes management OT - resilience OT - stress OT - type 1 diabetes COIS- DD serves as an independent consultant for Dexcom and Insulet outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/03/31 06:00 MHDA- 2023/03/31 06:01 PMCR- 2022/02/21 CRDT- 2023/03/30 02:45 PHST- 2021/12/14 00:00 [received] PHST- 2022/01/24 00:00 [accepted] PHST- 2023/03/31 06:01 [medline] PHST- 2023/03/30 02:45 [entrez] PHST- 2023/03/31 06:00 [pubmed] PHST- 2022/02/21 00:00 [pmc-release] AID - 10.3389/fcdhc.2022.835739 [doi] PST - epublish SO - Front Clin Diabetes Healthc. 2022 Feb 21;3:835739. doi: 10.3389/fcdhc.2022.835739. eCollection 2022. PMID- 24636873 OWN - NLM STAT- MEDLINE DCOM- 20150930 LR - 20181202 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 67 DP - 2014 Jun TI - Effects of chronotype and time of day on the vigilance decrement during simulated driving. PG - 113-8 LID - S0001-4575(14)00065-7 [pii] LID - 10.1016/j.aap.2014.02.020 [doi] AB - The current study tested for the first time the effect of individual differences in circadian rhythmicity (chronotype) on both driving performance and its evolution along time on task. Morning-type and evening-type female participants were tested in morning (8 am) and evening (8 pm) sessions, in which we controlled for prior sleep duration and prior wake. Measures of body temperature, subjective activation and affect, reaction times (RT) in the Psychomotor Vigilance Task (PVT), behavioral performance (error position) and EEG alpha power during simulated driving were collected. The main result showed strong linear increments of mean and standard deviation of error position along time on task (vigilance decrement) when evening-type participants drove at their non-optimal time of day, that is, during the morning session. In contrast, driving performance in the morning-type group remained stable over time on task and was not affected by time of day. This finding can be due to differences in personality traits (e.g., conscientiousness, sensation seeking) and task appraisal associated to extreme chronotypes. The consideration of chronotype in vigilance and driving tasks can enhance safety and human performance by promoting work schedules and countermeasures to prevent failures in the accomplishment of tasks under non-optimal circadian conditions. CI - Copyright © 2014 Elsevier Ltd. All rights reserved. FAU - Correa, Angel AU - Correa A AD - Departamento de Psicología Experimental, Universidad de Granada, Granada, Spain; Centro de Investigación Mente, Cerebro y Comportamiento, Universidad de Granada, Granada, Spain. Electronic address: act@ugr.es. FAU - Molina, Enrique AU - Molina E AD - Departamento de Psicología Experimental, Universidad de Granada, Granada, Spain; Centro de Investigación Mente, Cerebro y Comportamiento, Universidad de Granada, Granada, Spain. FAU - Sanabria, Daniel AU - Sanabria D AD - Departamento de Psicología Experimental, Universidad de Granada, Granada, Spain; Centro de Investigación Mente, Cerebro y Comportamiento, Universidad de Granada, Granada, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140304 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Adolescent MH - Adult MH - Attention/*physiology MH - Automobile Driving/*psychology MH - Circadian Rhythm/*physiology MH - Computer Simulation MH - Female MH - Humans MH - *Individuality MH - Reaction Time/*physiology MH - Time Factors MH - Young Adult OTO - NOTNLM OT - Circadian OT - EEG OT - Morningness OT - Neuroergonomics OT - PVT OT - Time on task EDAT- 2014/03/19 06:00 MHDA- 2015/10/01 06:00 CRDT- 2014/03/19 06:00 PHST- 2013/08/14 00:00 [received] PHST- 2014/02/25 00:00 [revised] PHST- 2014/02/25 00:00 [accepted] PHST- 2014/03/19 06:00 [entrez] PHST- 2014/03/19 06:00 [pubmed] PHST- 2015/10/01 06:00 [medline] AID - S0001-4575(14)00065-7 [pii] AID - 10.1016/j.aap.2014.02.020 [doi] PST - ppublish SO - Accid Anal Prev. 2014 Jun;67:113-8. doi: 10.1016/j.aap.2014.02.020. Epub 2014 Mar 4. PMID- 33301841 OWN - NLM STAT- MEDLINE DCOM- 20210205 LR - 20210205 IS - 1532-2939 (Electronic) IS - 0195-6701 (Print) IS - 0195-6701 (Linking) VI - 108 DP - 2021 Feb TI - Heat stress and PPE during COVID-19: impact on healthcare workers' performance, safety and well-being in NHS settings. PG - 185-188 LID - S0195-6701(20)30551-X [pii] LID - 10.1016/j.jhin.2020.11.027 [doi] AB - Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its consequences. Respondents reported experiencing several heat-related illness symptoms, and heat stress impaired both cognitive and physical performance. The majority of respondents stated that wearing PPE made their job more difficult. These, and additional, responses suggest that modification to current working practices is required urgently to improve the resilience of HCWs to wearing PPE during pandemics. CI - Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. FAU - Davey, S L AU - Davey SL AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. Electronic address: ad4782@coventry.ac.uk. FAU - Lee, B J AU - Lee BJ AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. FAU - Robbins, T AU - Robbins T AD - University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK; Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK. FAU - Randeva, H AU - Randeva H AD - University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK. FAU - Thake, C D AU - Thake CD AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. LA - eng PT - Journal Article DEP - 20201207 PL - England TA - J Hosp Infect JT - The Journal of hospital infection JID - 8007166 SB - IM MH - Adult MH - COVID-19/diagnosis/epidemiology/prevention & control/virology MH - Cognitive Dysfunction/etiology MH - Extreme Environments MH - Female MH - Health Personnel/*psychology/statistics & numerical data MH - Heat-Shock Response/*physiology MH - Humans MH - Male MH - Middle Aged MH - Perception/physiology MH - Personal Protective Equipment/*adverse effects MH - SARS-CoV-2/genetics MH - Safety MH - State Medicine/organization & administration MH - Surveys and Questionnaires/statistics & numerical data MH - United Kingdom/epidemiology MH - Work Performance/*statistics & numerical data PMC - PMC7720696 OTO - NOTNLM OT - COVID-19 OT - Extreme environments OT - Healthcare workers OT - Heat stress OT - Heat-related illness OT - Personal protective equipment OT - SARS-CoV-2 EDAT- 2020/12/11 06:00 MHDA- 2021/02/07 06:00 PMCR- 2020/12/07 CRDT- 2020/12/10 20:09 PHST- 2020/10/12 00:00 [received] PHST- 2020/11/25 00:00 [revised] PHST- 2020/11/27 00:00 [accepted] PHST- 2020/12/11 06:00 [pubmed] PHST- 2021/02/07 06:00 [medline] PHST- 2020/12/10 20:09 [entrez] PHST- 2020/12/07 00:00 [pmc-release] AID - S0195-6701(20)30551-X [pii] AID - 10.1016/j.jhin.2020.11.027 [doi] PST - ppublish SO - J Hosp Infect. 2021 Feb;108:185-188. doi: 10.1016/j.jhin.2020.11.027. Epub 2020 Dec 7. PMID- 22337145 OWN - NLM STAT- MEDLINE DCOM- 20130314 LR - 20121005 IS - 1532-2149 (Electronic) IS - 1090-3801 (Linking) VI - 16 IP - 3 DP - 2012 Mar TI - Coping when pain is a potential threat: the efficacy of acceptance versus cognitive distraction. PG - 390-400 LID - 10.1002/j.1532-2149.2011.00019.x [doi] AB - This experiment investigated the impact of brief training in acceptance versus distraction-based pain management on experimental pain tolerance in conditions of lower and higher potential threats. One hundred fifty-one pain-free Chinese adults (93 women, 58 men) randomly assigned to acceptance, distraction or pain education control conditions engaged in a cold pressor test (CPT) after reading validated orienting information designed to prime either the safety of the CPT (lower threat) or symptoms and damaging effects of exposure to extreme cold (higher threat). A 2 (threat level) × 3 (training strategy) analysis of covariance, controlling for pre-intervention pain tolerance and education, indicated the acceptance group was more pain tolerant than other training groups. This main effect was qualified by an interaction with threat level: in the lower threat condition, acceptance group participants were more pain tolerant than peers in the distraction or pain education groups while no training group differences were found in the higher threat condition. Supplementary analyses identified catastrophizing as a partial mediator of training group differences in pain tolerance. In summary, findings suggested acceptance-based coping is superior to distraction as a means of managing experimental pain, particularly when pain sensations are viewed as comparatively low in potential threat. CI - © 2011 European Federation of International Association for the Study of Pain Chapters. FAU - Jackson, T AU - Jackson T AD - Key Laboratory of Cognition & Personality, Southwest University, Chongqing, China. toddjackson@hotmail.com FAU - Yang, Z AU - Yang Z FAU - Li, X AU - Li X FAU - Chen, H AU - Chen H FAU - Huang, X AU - Huang X FAU - Meng, J AU - Meng J LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20111219 PL - England TA - Eur J Pain JT - European journal of pain (London, England) JID - 9801774 SB - IM MH - *Adaptation, Psychological MH - Adolescent MH - Adult MH - *Attention MH - Female MH - Humans MH - Male MH - Pain/*psychology MH - Pain Measurement MH - Pain Threshold/*psychology MH - Patient Education as Topic EDAT- 2012/02/18 06:00 MHDA- 2013/03/15 06:00 CRDT- 2012/02/17 06:00 PHST- 2011/09/03 00:00 [accepted] PHST- 2012/02/17 06:00 [entrez] PHST- 2012/02/18 06:00 [pubmed] PHST- 2013/03/15 06:00 [medline] AID - 10.1002/j.1532-2149.2011.00019.x [doi] PST - ppublish SO - Eur J Pain. 2012 Mar;16(3):390-400. doi: 10.1002/j.1532-2149.2011.00019.x. Epub 2011 Dec 19. PMID- 31764803 OWN - NLM STAT- MEDLINE DCOM- 20191206 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 98 IP - 47 DP - 2019 Nov TI - Predictor of sleep difficulty among community dwelling older populations in 2 African settings. PG - e17971 LID - 10.1097/MD.0000000000017971 [doi] LID - e17971 AB - Sleep deprivation is a common phenomenon among older population and is commonly linked to behavioral, physiological, and psychosocial factors. Not much is known about sleep deprivation among older population in Africa. Therefore, in this study we aimed to investigate the basic sociodemographic and psychosocial predictors of self-reported sleep deprivation among older population.In this study we analyzed cross-sectional data on 1495 community dwelling men and women aged 50 years and above. Data were collected from the SAGE Well-Being of Older People Study conducted in South Africa and Uganda. Outcome variable was self-reported sleep difficulty last 30 days. Multivariable logistic regression models were used to identify the variables significantly associated with sleep difficulty.The prevalence of mild-moderate sleep difficulty was 32.6% (27.9, 37.6) and severe/extreme 23.0% (20.3, 26.0) respectively. Multivariable analysis revealed that sleep difficulty was associated with several behavioral, environment, and illness conditions. In South Africa, those who reported dissatisfaction with living condition had 1.592 [1.087, 2.787] times higher odds of reporting mild/moderate sleep difficulty. Poor subjective quality of life (QoL) was associated with higher odds of severe/extreme sleep difficulties (odds ratios [OR] = 4.590, 95% confidence interval [CI] = 2.641, 7.977 for South Africa, and OR = 4.461, 95% CI = 2.048 and 9.716 for Uganda). In Uganda, perceived depression was associated with higher odds of severe/extreme (OR = 2.452, 95% CI = 1.073, 5.602) sleep difficulties among men, and both mild/moderate (OR = 1.717; 95% CI = 1.011, 2.914) and severe/extreme sleep difficulties among women (OR = 2.504, 95% CI = 1.408, 4.453).More than half of the participants had sleep difficulty of certain degrees, emphasising an urgent need for intervention for sleep deprivation in the population. Interventions targeting to promote subjective health, quality of life, and living environment may prove beneficial for improving sleep health in this regard. FAU - Wang, Chao AU - Wang C AD - School of Safety Engineering. AD - School of Public Policy and Management, China University of Mining and Technology, Xuzhou, Jiangsu. FAU - Liu, Jiaxuan AU - Liu J AD - Queen Mary School, Nanchang University, Nanchang, Jiangxi. FAU - Li, Zhifei AU - Li Z AD - China National Center for Biotechnology Development, Beijing. FAU - Ji, Lu AU - Ji L AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Wang, Ruoxi AU - Wang R AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Song, Hongxun AU - Song H AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Mao, Yiqing AU - Mao Y AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Bishwajit, Ghose AU - Bishwajit G AD - Faculty of Social Sciences, School of International Development and Global Studies, University of Ottawa, Ottawa, ON , Canada. FAU - Zhang, Baoming AU - Zhang B AD - General Hospital of Southern Theater Command, PLA, Guangzhou, P.R. China. FAU - Tang, Shangfeng AU - Tang S AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Aged MH - Aged, 80 and over MH - Cross-Sectional Studies MH - Female MH - Humans MH - Independent Living MH - Male MH - Middle Aged MH - Prevalence MH - Self Report MH - Sleep Deprivation/*epidemiology/psychology MH - Sleep Initiation and Maintenance Disorders/*epidemiology/psychology MH - Sociological Factors MH - South Africa/epidemiology MH - Uganda/epidemiology PMC - PMC6882581 COIS- The authors have no conflicts of interest to disclose. EDAT- 2019/11/26 06:00 MHDA- 2019/12/18 06:00 PMCR- 2019/11/22 CRDT- 2019/11/26 06:00 PHST- 2019/11/26 06:00 [entrez] PHST- 2019/11/26 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/11/22 00:00 [pmc-release] AID - 00005792-201911220-00034 [pii] AID - MD-D-18-08546 [pii] AID - 10.1097/MD.0000000000017971 [doi] PST - ppublish SO - Medicine (Baltimore). 2019 Nov;98(47):e17971. doi: 10.1097/MD.0000000000017971. PMID- 36670754 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240911 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 13 IP - 2 DP - 2023 Jan 6 TI - Mobile Zoos and Other Itinerant Animal Handling Events: Current Status and Recommendations for Future Policies. LID - 10.3390/ani13020214 [doi] LID - 214 AB - Mobile zoos are events in which non-domesticated (exotic) and domesticated species are transported to venues such as schools, hospitals, parties, and community centres, for the purposes of education, entertainment, or social and therapeutic assistance. We conducted literature searches and surveyed related government agencies regarding existing provisions within laws and policies, number of mobile zoos, and formal guidance issued concerning operation of such events in 74 countries or regions. We also examined governmental and non-governmental guidance standards for mobile zoos, as well as websites for mobile zoo operations, assessed promotional or educational materials for scientific accuracy, and recorded the diversity of species in use. We used the EMODE (Easy, Moderate, Difficult, or Extreme) algorithm, to evaluate identified species associated with mobile zoos for their suitability for keeping. We recorded 14 areas of concern regarding animal biology and public health and safety, and 8 areas of false and misleading content in promotional or educational materials. We identified at least 341 species used for mobile zoos. Mobile zoos are largely unregulated, unmonitored, and uncontrolled, and appear to be increasing. Issues regarding poor animal welfare, public health and safety, and education raise several serious concerns. Using the precautionary principle when empirical evidence was not available, we advise that exotic species should not be used for mobile zoos and similar itinerant events. FAU - Warwick, Clifford AU - Warwick C AD - Emergent Disease Foundation, 71-75 Shelton Street, Covent Garden, London WC2H 9JQ, UK. FAU - Pilny, Anthony AU - Pilny A AD - Arizona Exotic Animal Hospital, 2340 E Beardsley Road Ste 100, Phoenix, AZ 85024, USA. FAU - Steedman, Catrina AU - Steedman C AUID- ORCID: 0000-0003-2809-1445 AD - Emergent Disease Foundation, 71-75 Shelton Street, Covent Garden, London WC2H 9JQ, UK. FAU - Howell, Tiffani AU - Howell T AUID- ORCID: 0000-0002-4932-5792 AD - School of Psychology and Public Health, La Trobe University, P.O. Box 199, Bendigo, VIC 3552, Australia. FAU - Martínez-Silvestre, Albert AU - Martínez-Silvestre A AUID- ORCID: 0000-0003-3382-6784 AD - Catalonian Reptiles and Amphibians Rescue Centre (CRARC), 08783 Masquefa, Spain. FAU - Cadenas, Vanessa AU - Cadenas V AD - Animal Protection Biodiversity & Environment Section, Government of Catalonia, 43004 Tarragona, Spain. FAU - Grant, Rachel AU - Grant R AD - School of Applied Sciences, London South Bank University, 103 Borough Rd, London SE1 0AA, UK. LA - eng GR - n/a/World Animal Protection Canada/ GR - n/a/ZooCheck Canada/ PT - Journal Article DEP - 20230106 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC9854913 OTO - NOTNLM OT - animal assisted interventions OT - animal welfare OT - injury OT - legislation OT - mobile live animal programs OT - mobile zoos OT - one-health OT - precautionary principle OT - public health OT - safety COIS- The authors declare no conflict of interest. EDAT- 2023/01/22 06:00 MHDA- 2023/01/22 06:01 PMCR- 2023/01/06 CRDT- 2023/01/21 01:02 PHST- 2022/11/07 00:00 [received] PHST- 2022/12/07 00:00 [revised] PHST- 2022/12/25 00:00 [accepted] PHST- 2023/01/21 01:02 [entrez] PHST- 2023/01/22 06:00 [pubmed] PHST- 2023/01/22 06:01 [medline] PHST- 2023/01/06 00:00 [pmc-release] AID - ani13020214 [pii] AID - animals-13-00214 [pii] AID - 10.3390/ani13020214 [doi] PST - epublish SO - Animals (Basel). 2023 Jan 6;13(2):214. doi: 10.3390/ani13020214. PMID- 33761277 OWN - NLM STAT- MEDLINE DCOM- 20210507 LR - 20220402 IS - 1931-843X (Electronic) IS - 1540-9996 (Print) IS - 1540-9996 (Linking) VI - 30 IP - 4 DP - 2021 Apr TI - The Intersection of Work and Home Challenges Faced by Physician Mothers During the Coronavirus Disease 2019 Pandemic: A Mixed-Methods Analysis. PG - 514-524 LID - 10.1089/jwh.2020.8964 [doi] AB - Objectives: The coronavirus disease 2019 (COVID-19) pandemic has presented extreme challenges for health care workers. This study sought to characterize challenges faced by physician mothers, compare differences in challenges by home and work characteristics, and elicit specific needs and potential solutions. Methods: We conducted a mixed-methods online survey of the Physician Moms Group (PMG) and PMG COVID19 Subgroup on Facebook from April 18th to 29th, 2020. We collected structured data on personal and professional characteristics and qualitative data on home and work concerns. We analyzed qualitative data thematically and used bivariate analyses to evaluate variation in themes by frontline status and children's ages. Results: We included 1,806 participants in analysis and identified 10 key themes. The most frequently identified need/solution was for Community and Government Support (n = 545, 47.1%). When comparing frontline and nonfrontline physicians, those on the frontline more frequently raised concerns about Personal Health and Safety (67.8% vs. 48.4%, p < 0.001), Organizational Communication and Relationships (31.8% vs. 23.8%, p < 0.001), and Family Health and Safety (27.2 vs. 16.6, p < 0.001), while nonfrontline physicians more frequently addressed Patient Care and Safety (56.4% vs. 48.2%, p < 0.001) and Financial/Job Security (33.8% vs. 46.9%, p < 0.001). Participants with an elementary school-aged child more frequently raised concerns about Parenting/Homeschooling (44.0% vs. 31.1%, p < 0.001) and Work/Life Balance (28.4 vs. 13.7, p < 0.001), and participants with a preschool-aged child more frequently addressed Access to Childcare (24.0 vs. 7.7, p < 0.001) and Spouse/Partner Relationships (15.8 vs. 9.5, p < 0.001), when compared to those without children in these age groups. Conclusions: The physician workforce is not homogenous. Health care and government leaders need to understand these diverse challenges in order to meet physicians' professional and family needs during the pandemic. FAU - Halley, Meghan C AU - Halley MC AD - Center for Biomedical Ethics, Stanford University, Stanford, California, USA. FAU - Mathews, Kusum S AU - Mathews KS AD - Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. AD - Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Diamond, Lisa C AU - Diamond LC AD - Department of Psychiatry and Behavioral Sciences, Immigrant Health and Cancer Disparities Service, Hospital Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA. AD - Department of Medicine, Hospital Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA. FAU - Linos, Elizabeth AU - Linos E AD - Goldman School of Public Policy, University of California, Berkeley, California, USA. FAU - Sarkar, Urmimala AU - Sarkar U AD - Division of General Internal Medicine, Department of Medicine, Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital, University of California, San Francisco, California, USA. FAU - Mangurian, Christina AU - Mangurian C AD - Department of Psychiatry and Behavioral Science, Weill Institute for Neurosciences, University of California, San Francisco, California, USA. AD - Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA. FAU - Sabry, Hala AU - Sabry H AD - Emergency Medicine Physician, Vituity, Founder of Physician Moms Group and CEO of Physician Digital Services, Claremont, California, USA. FAU - Goyal, Monika K AU - Goyal MK AD - Department of Pediatrics, Children's National Hospital, George Washington University, Washington, District of Columbia, USA. AD - Department of Emergency Medicine, Children's National Hospital, George Washington University, Washington, District of Columbia, USA. FAU - Olazo, Kristan AU - Olazo K AD - Division of General Internal Medicine, Department of Medicine, Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital, University of California, San Francisco, California, USA. FAU - Miller, Emily G AU - Miller EG AD - Center for Biomedical Ethics, Stanford University, Stanford, California, USA. FAU - Jagsi, Reshma AU - Jagsi R AD - Department of Radiation Oncology, Center for Bioethics and Social Sciences in Medicine, University of Michigan, Ann Arbor, Michigan, USA. FAU - Linos, Eleni AU - Linos E AD - Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA. AD - Department of Epidemiology by Courtesy, Stanford University School of Medicine, Stanford, California, USA. LA - eng GR - R01 MH112420/MH/NIMH NIH HHS/United States GR - P30 CA008748/CA/NCI NIH HHS/United States GR - U01 HG010218/HG/NHGRI NIH HHS/United States GR - K24 CA212294/CA/NCI NIH HHS/United States GR - K24 AR075060/AR/NIAMS NIH HHS/United States GR - R03 MD011654/MD/NIMHD NIH HHS/United States GR - K23 HL130648/HL/NHLBI NIH HHS/United States GR - K07 CA184037/CA/NCI NIH HHS/United States GR - DP2 CA225433/CA/NCI NIH HHS/United States GR - UL1 TR003142/TR/NCATS NIH HHS/United States GR - U01 HL122998/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20210323 PL - United States TA - J Womens Health (Larchmt) JT - Journal of women's health (2002) JID - 101159262 SB - IM MH - Adult MH - COVID-19/epidemiology/prevention & control/*psychology MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Mental Health MH - Middle Aged MH - Mothers/*psychology MH - Occupational Stress/*psychology MH - *Pandemics MH - Physicians, Women/*psychology MH - SARS-CoV-2 MH - *Work-Life Balance MH - Young Adult PMC - PMC8182656 OTO - NOTNLM OT - COVID-19 OT - mothers OT - occupational stress OT - physicians OT - women OT - work-life balance COIS- M.C.H. is supported by the NIH (3U01HG010218-03S2-03S2 and 5UL1TR003142-02). K.S.M. is supported by the NIH (K23HL130648 and U01HL122998) and serves on the BREATHE Trial Steering Committee supported by Roivant/Kinevant Sciences. L.C.D. is supported by the NIH (P30 CA008748 and K07 CA184037). She receives author royalties for a textbook published by Multilingual Matters, an imprint of Channel View Publications, on the topic of language barriers in health care. U.S. is supported by the NIH (K24CA212294). She has received grant funding for unrelated work from NIH, the Agency for Health care Research and Quality, U.S. Food and Drug Administration, The California Health Care Foundation, Blue Shield of California Foundation, the Gordon and Betty Moore Foundation, and the Commonwealth Fund. She is also supported by an unrestricted gift from the Doctors Company Foundation and holds contract funding from She holds contract funding from AppliedVR, InquisitHealth, and Somnology. She serves as am uncompensated scientific/expert advisor for nonprofit organizations HealthTech 4 Medicaid and HopeLab. She has been a clinical advisor for Omada Health, and an advisory board member for Doximity. C.M. is supported by several grants including the National Institutes of Mental Health (R01MH112420), Genentech, the Doris Duke Charitable Foundation (Grant 2015211), the California Health Care Foundation. She is a founding member of TIME'S UP Healthcare, but receives no financial compensation from that organization. In 2019, she received one-time speaking honoraria from Uncommon Bold. M.K.G. is supported by the NIH (R01HD070910, R03MD011654). R.J. has stock options as compensation for her advisory board role in Equity Quotient, a company that evaluates culture in health care companies; she has received personal fees from Amgen and Vizient and grants for unrelated work from the National Institutes of Health, the Doris Duke Foundation, the Greenwall Foundation, the Komen Foundation, and Blue Cross Blue Shield of Michigan for the Michigan Radiation Oncology Quality Consortium. She has a contract to conduct an investigator initiated study with Genentech. She has served as an expert witness for Sherinian and Hasso and Dressman Benzinger LaVelle. She is an uncompensated founding member of TIME'S UP Healthcare and a member of the Board of Directors of ASCO. E.L. is supported by the NIH (grants DP2CA225433 and K24AR075060). EDAT- 2021/03/25 06:00 MHDA- 2021/05/08 06:00 PMCR- 2022/04/01 CRDT- 2021/03/24 20:09 PHST- 2021/03/25 06:00 [pubmed] PHST- 2021/05/08 06:00 [medline] PHST- 2021/03/24 20:09 [entrez] PHST- 2022/04/01 00:00 [pmc-release] AID - 10.1089/jwh.2020.8964 [pii] AID - 10.1089/jwh.2020.8964 [doi] PST - ppublish SO - J Womens Health (Larchmt). 2021 Apr;30(4):514-524. doi: 10.1089/jwh.2020.8964. Epub 2021 Mar 23. PMID- 30305058 OWN - NLM STAT- MEDLINE DCOM- 20190220 LR - 20231104 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 18 IP - 1 DP - 2018 Oct 11 TI - Maternal mortality in the Gaza strip: a look at causes and solutions. PG - 396 LID - 10.1186/s12884-018-2037-1 [doi] LID - 396 AB - BACKGROUND: Maternal mortality is an important health indicator for the overall health of a population. This study assessed the causes and contributing factors to maternal mortality that occurred in the Gaza-Strip between July 2014 and June 2015. METHODS: This is a retrospective study that used both quantitative and qualitative data. The data were collected from available medical records, investigation reports, death certificates, and field interviews with healthcare professionals as well as families. RESULTS: A total of 18 maternal mortalities occurred in Gaza between 1st July 2014 and June 30th 2015. Age at time of death ranged from 18 to 44 years, with 44.4% occurring before the age of 35 years. About 22.2% were primiparous, while 55.6% were grand multiparous women. The most common causes of death were sepsis, postpartum haemorrhage, and pulmonary embolism. The most striking deficiency was very poor medical documentation which was observed in 17 cases (94%). In addition, poor communication between doctors and women and their families or among healthcare teams was noticed in nine cases (50%). These were repeatedly described by families during interviews. Further aspects surfacing in many interviews were distrust by families towards clinicians and poor understanding of health conditions by women. Other factors included socioeconomic conditions, poor antenatal attendance and the impact of the 2014 war. Low morale among medical staff was expressed by most interviewed clinicians, as well as the fear of being blamed by families and management in case of adverse events. Substandard care and lack of appropriate supervision were also found in some cases. CONCLUSIONS: This study revealed deficiencies in maternity care, some of which were linked to the socioeconomic situation and the 2014 war. Others show poor implementation of clinical guidelines and lack of professional skills in communication and teamwork. Specialised training should be offered for clinicians in order to improve these aspects. However, the most striking deficiency was the extremely poor documentation, reflecting a lack of awareness among clinicians regarding its importance. Local policymakers should focus on systematic application of quality improvement strategies in order to achieve greater patient safety and further reductions in the maternal mortality rate. FAU - Bӧttcher, Bettina AU - Bӧttcher B AUID- ORCID: 0000-0001-7457-7265 AD - Faculty of Medicine, Islamic University of Gaza, P. O. Box 108, Gaza strip, Gaza, Palestine. Bettina.bottcher@yahoo.co.uk. FAU - Abu-El-Noor, Nasser AU - Abu-El-Noor N AD - Faculty of Nursing, Islamic University of Gaza, P. O. Box 108, Gaza Strip, Gaza, Palestine. FAU - Aldabbour, Belal AU - Aldabbour B AD - Faculty of Medicine, Islamic University of Gaza, P. O. Box 108, Gaza strip, Gaza, Palestine. FAU - Naim, Fadel Naim AU - Naim FN AD - Faculty of Medicine, Islamic University of Gaza, P. O. Box 108, Gaza strip, Gaza, Palestine. FAU - Aljeesh, Yousef AU - Aljeesh Y AD - Faculty of Nursing, Islamic University of Gaza, P. O. Box 108, Gaza Strip, Gaza, Palestine. LA - eng GR - Limited funding was received only for transport costs/UNDP/ PT - Journal Article DEP - 20181011 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Adolescent MH - Adult MH - Armed Conflicts MH - Communication MH - Documentation/standards MH - Female MH - Humans MH - Maternal Mortality MH - Medical Audit MH - Medical Staff, Hospital/organization & administration/psychology MH - Middle East MH - Morale MH - Patient Care Team/organization & administration MH - Postpartum Hemorrhage/*mortality MH - Pregnancy MH - Prenatal Care MH - Professional-Family Relations MH - Pulmonary Embolism/*mortality MH - *Quality of Health Care MH - Retrospective Studies MH - Sepsis/*mortality MH - Socioeconomic Factors MH - Young Adult PMC - PMC6180491 OTO - NOTNLM OT - Clinical audit OT - Gaza-strip OT - Maternal mortality OT - Medical documentation OT - Palestine OT - Patient safety OT - Quality improvement COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: No Institutional Review Board (IRB) exists at the Palestinian Ministry of Health (MoH) in the Gaza-Strip, which retains jurisdiction over providing approvals for access to medical records and medical databases owned by each individual hospital. The authorized body to provide approvals for studies that involve secondary health data as well as collection and analysis of primary data from both healthcare providers and patients is provided by the Human Resources Department at the MoH in the Gaza-Strip. Therefore, ethical approval for this study was obtained from the Human Resources Department at the MoH in the Gaza-Strip, which issues ethical and administrative approvals for studies involving patients and their families. The approvals were then presented to the administrative bodies of the local hospitals in the Gaza-Strip, which in turn gave their approval and provided the research team with access to medical records housed by the individual hospitals and the available contact information for the families of deceased women who were identified to be part of the potential sample for this study. The procedure, followed in Gaza at the time of this study, did not require approval by relatives to view the medical documentation of the deceased women. The hospitals included in this study were Al-Shifa Hospital in Gaza-City, Shuhada Al-Aqsa Hospital in Deir Al-Balah, Nasser Hopsital in Khan Younis, Al-Helal Al-Emirati Hospital in Rafah and Al-Awda Hospital in Jabalia Refugee Camp, which was the only private hospital. All approvals for this study had been obtained prior to data collection. In addition, and before conducting the interviews with family members or healthcare providers, written consent was obtained from those who were interviewed in person, whereas verbal consent was obtained from participants who were interviewed over the phone due to family preference. This had been agreed to by the Human Resources Department of the MoH. Prior to obtaining consent, the aims of the study were explained to the participants, and they were informed that they had the right to refuse participation in the study, or to withdraw at any time without being penalized. The collected data were kept under high confidentiality and anonymity as each case was assigned a code number. The women’s confidentiality was preserved throughout the study. It was explained to participants that the data collected might be published after having been analysed at the aggregate level. CONSENT FOR PUBLICATION: All patients’ data were kept strictly confidential and anonymity was preserved throughout the research process. Consent for publication was obtained from the interviewees and the Human Resources Department at the Ministry of Health. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/10/12 06:00 MHDA- 2019/03/21 06:00 PMCR- 2018/10/11 CRDT- 2018/10/12 06:00 PHST- 2017/09/11 00:00 [received] PHST- 2018/09/28 00:00 [accepted] PHST- 2018/10/12 06:00 [entrez] PHST- 2018/10/12 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2018/10/11 00:00 [pmc-release] AID - 10.1186/s12884-018-2037-1 [pii] AID - 2037 [pii] AID - 10.1186/s12884-018-2037-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2018 Oct 11;18(1):396. doi: 10.1186/s12884-018-2037-1. PMID- 26615171 OWN - NLM STAT- MEDLINE DCOM- 20160930 LR - 20240724 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 33 Suppl 4 DP - 2015 Nov 27 TI - Vaccine hesitancy: Causes, consequences, and a call to action. PG - D66-71 LID - S0264-410X(15)01311-0 [pii] LID - 10.1016/j.vaccine.2015.09.035 [doi] AB - Vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. There is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. Although vaccination is a norm in the U.S. and the majority of parents vaccinate their children, many do so amid concerns. The proportion of parents claiming non-medical exemptions to school immunization requirements has been increasing over the past decade. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pertussis, resulting in the unnecessary suffering of young children and waste of limited public health resources. Vaccine hesitancy is an extremely important issue that needs to be addressed because effective control of vaccine-preventable diseases generally requires indefinite maintenance of extremely high rates of timely vaccination. The multifactorial and complex causes of vaccine hesitancy require a broad range of approaches on the individual, provider, health system, and national levels. These include standardized measurement tools to quantify and locate clustering of vaccine hesitancy and better understand issues of trust; rapid, independent, and transparent review of an enhanced and appropriately funded vaccine safety system; adequate reimbursement for vaccine risk communication in doctors' offices; and individually tailored messages for parents who have vaccine concerns, especially first-time pregnant women. The potential of vaccines to prevent illness and save lives has never been greater. Yet, that potential is directly dependent on parental acceptance of vaccines, which requires confidence in vaccines, healthcare providers who recommend and administer vaccines, and the systems to make sure vaccines are safe. CI - Copyright © 2015 American Journal of Preventive Medicine and Elsevier Ltd. Published by Elsevier Ltd.. All rights reserved. FAU - Salmon, Daniel A AU - Salmon DA AD - Departments of International Health and Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: dsalmon1@jhu.edu. FAU - Dudley, Matthew Z AU - Dudley MZ AD - Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Glanz, Jason M AU - Glanz JM AD - Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, United States; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States. FAU - Omer, Saad B AU - Omer SB AD - Rollins School of Public Health, Emory University, Atlanta, GA, United States. LA - eng PT - Journal Article PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Vaccines) SB - IM MH - Child MH - Disease Outbreaks/*prevention & control MH - Female MH - Health Knowledge, Attitudes, Practice MH - Health Personnel MH - Humans MH - *Immunization Programs MH - *Parents/psychology MH - Patient Compliance/psychology MH - Pregnancy MH - *Treatment Refusal/psychology MH - United States MH - Vaccination/psychology MH - Vaccines/*adverse effects EDAT- 2015/11/29 06:00 MHDA- 2016/10/01 06:00 CRDT- 2015/11/29 06:00 PHST- 2015/11/29 06:00 [entrez] PHST- 2015/11/29 06:00 [pubmed] PHST- 2016/10/01 06:00 [medline] AID - S0264-410X(15)01311-0 [pii] AID - 10.1016/j.vaccine.2015.09.035 [doi] PST - ppublish SO - Vaccine. 2015 Nov 27;33 Suppl 4:D66-71. doi: 10.1016/j.vaccine.2015.09.035. PMID- 26337116 OWN - NLM STAT- MEDLINE DCOM- 20160912 LR - 20151123 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 49 IP - 6 Suppl 4 DP - 2015 Dec TI - Vaccine Hesitancy: Causes, Consequences, and a Call to Action. PG - S391-8 LID - S0749-3797(15)00314-1 [pii] LID - 10.1016/j.amepre.2015.06.009 [doi] AB - Vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. There is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. Although vaccination is a norm in the U.S. and the majority of parents vaccinate their children, many do so amid concerns. The proportion of parents claiming non-medical exemptions to school immunization requirements has been increasing over the past decade. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pertussis, resulting in the unnecessary suffering of young children and waste of limited public health resources. Vaccine hesitancy is an extremely important issue that needs to be addressed because effective control of vaccine-preventable diseases generally requires indefinite maintenance of extremely high rates of timely vaccination. The multifactorial and complex causes of vaccine hesitancy require a broad range of approaches on the individual, provider, health system, and national levels. These include standardized measurement tools to quantify and locate clustering of vaccine hesitancy and better understand issues of trust; rapid, independent, and transparent review of an enhanced and appropriately funded vaccine safety system; adequate reimbursement for vaccine risk communication in doctors' offices; and individually tailored messages for parents who have vaccine concerns, especially first-time pregnant women. The potential of vaccines to prevent illness and save lives has never been greater. Yet, that potential is directly dependent on parental acceptance of vaccines, which requires confidence in vaccines, healthcare providers who recommend and administer vaccines, and the systems to make sure vaccines are safe. CI - Copyright © 2015 by American Journal of Preventive Medicine and Elsevier Ltd. Published by Elsevier Inc. All rights reserved. FAU - Salmon, Daniel A AU - Salmon DA AD - Departments of International Health and Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: dsalmon1@jhu.edu. FAU - Dudley, Matthew Z AU - Dudley MZ AD - Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Glanz, Jason M AU - Glanz JM AD - Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado. FAU - Omer, Saad B AU - Omer SB AD - Rollins School of Public Health, Emory University, Atlanta, Georgia. LA - eng PT - Journal Article DEP - 20150831 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 RN - 0 (Vaccines) SB - IM MH - Consumer Health Information MH - Disease Outbreaks/*prevention & control MH - Health Knowledge, Attitudes, Practice MH - Health Personnel MH - Humans MH - Parents/*psychology MH - Risk Assessment MH - Treatment Refusal/*psychology MH - United States MH - Vaccines/*administration & dosage EDAT- 2015/09/05 06:00 MHDA- 2016/09/13 06:00 CRDT- 2015/09/05 06:00 PHST- 2015/03/04 00:00 [received] PHST- 2015/06/03 00:00 [revised] PHST- 2015/06/17 00:00 [accepted] PHST- 2015/09/05 06:00 [entrez] PHST- 2015/09/05 06:00 [pubmed] PHST- 2016/09/13 06:00 [medline] AID - S0749-3797(15)00314-1 [pii] AID - 10.1016/j.amepre.2015.06.009 [doi] PST - ppublish SO - Am J Prev Med. 2015 Dec;49(6 Suppl 4):S391-8. doi: 10.1016/j.amepre.2015.06.009. Epub 2015 Aug 31. PMID- 25416718 OWN - NLM STAT- MEDLINE DCOM- 20151110 LR - 20220316 IS - 1538-7755 (Electronic) IS - 1055-9965 (Print) IS - 1055-9965 (Linking) VI - 24 IP - 2 DP - 2015 Feb TI - Biochemical estimation of noncompliance with smoking of very low nicotine content cigarettes. PG - 331-5 LID - 10.1158/1055-9965.EPI-14-1040 [doi] AB - BACKGROUND: The reduction of the nicotine content of cigarettes to nonaddicting levels is a potential federal regulatory intervention to reduce the prevalence of cigarette smoking and related disease. Many clinical trials on the effects and safety of nicotine reduction are ongoing. An important methodologic concern is noncompliance with reduced nicotine content cigarettes in the context of freely available conventional cigarettes. We propose two approaches using biomarkers to estimate noncompliance in smokers of very low nicotine content (VLNC) cigarettes in a clinical trial. METHODS: Data from 50 subjects in a study of gradual nicotine reduction were analyzed. Using plasma cotinine concentrations measured at baseline and while smoking VLNC cigarettes, we compared within-subject ratios of plasma cotinine comparing usual brand to VLNC in relation to nicotine content of these cigarettes. In another approach, we used nicotine pharmacokinetic data to estimate absolute plasma cotinine/cigarettes per day (CPD) threshold values for compliance based on the nicotine content of VLNC. RESULTS: The two approaches showed concordance, indicating at least 60% noncompliance with smoking VLNC. In a sensitivity analysis assuming extreme compensation and extreme values for nicotine metabolic parameters, noncompliance was still at least 40%, much higher than self-reported noncompliance. CONCLUSION: Biomarker analysis demonstrates a high degree of noncompliance with smoking VLNC cigarettes, indicating that smokers are supplementing these with conventional cigarettes. IMPACT: We propose a practical approach to assessing compliance with smoking VLNC in clinical trials of nicotine reduction. CI - ©2014 American Association for Cancer Research. FAU - Benowitz, Neal L AU - Benowitz NL AD - Department of Medicine, Division of Clinical Pharmacology and Experimental Therapeutics, University of California San Francisco, San Francisco, California. Department of Bioengineering & Therapeutic Sciences, Division of Clinical Pharmacology and Experimental Therapeutics, University of California San Francisco, San Francisco, California. neal.benowitz@ucsf.edu. FAU - Nardone, Natalie AU - Nardone N AD - Department of Medicine, University of California San Francisco, San Francisco, California. FAU - Hatsukami, Dorothy K AU - Hatsukami DK AD - Tobacco Research Program and Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota. FAU - Donny, Eric C AU - Donny EC AD - Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania. LA - eng GR - R01 CA078603/CA/NCI NIH HHS/United States GR - U54 DA031659/DA/NIDA NIH HHS/United States GR - P30 DA012393/DA/NIDA NIH HHS/United States GR - R01 CA78603/CA/NCI NIH HHS/United States GR - R01 DA12393/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20141121 PL - United States TA - Cancer Epidemiol Biomarkers Prev JT - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JID - 9200608 RN - 0 (Biomarkers) RN - 6M3C89ZY6R (Nicotine) RN - K5161X06LL (Cotinine) SB - IM MH - Biomarkers/*blood MH - Cotinine/*blood MH - Humans MH - Nicotine/*pharmacokinetics MH - *Patient Compliance MH - Smoking Cessation/*methods MH - *Smoking Prevention MH - Tobacco Use Cessation Devices PMC - PMC4323626 MID - NIHMS644857 COIS- Conflict of interest: Dr. Benowitz is a consultant to several pharmaceutical companies that market medications to aid smoking cessation and has served as a paid expert witness in litigation against tobacco companies. The other authors have no conflicts to declare. EDAT- 2014/11/25 06:00 MHDA- 2015/11/11 06:00 PMCR- 2016/02/01 CRDT- 2014/11/23 06:00 PHST- 2014/11/23 06:00 [entrez] PHST- 2014/11/25 06:00 [pubmed] PHST- 2015/11/11 06:00 [medline] PHST- 2016/02/01 00:00 [pmc-release] AID - 1055-9965.EPI-14-1040 [pii] AID - 10.1158/1055-9965.EPI-14-1040 [doi] PST - ppublish SO - Cancer Epidemiol Biomarkers Prev. 2015 Feb;24(2):331-5. doi: 10.1158/1055-9965.EPI-14-1040. Epub 2014 Nov 21. PMID- 26833304 OWN - NLM STAT- MEDLINE DCOM- 20160929 LR - 20220411 IS - 1865-8652 (Electronic) IS - 0741-238X (Print) IS - 0741-238X (Linking) VI - 33 IP - 2 DP - 2016 Feb TI - Assessing Changes in Chronic Spontaneous/Idiopathic Urticaria: Comparisons of Patient-Reported Outcomes Using Latent Growth Modeling. PG - 214-24 LID - 10.1007/s12325-016-0282-0 [doi] AB - INTRODUCTION: Assessing the consequences of chronic spontaneous/idiopathic urticaria (CSU) requires the evaluation of health-related quality of life (HRQoL) associated with the severity of CSU signs and symptoms. It is important to understand how signs, symptoms, and HRQoL change over time in CSU. Evidence is lacking on how closely changes in signs and symptoms of CSU are related to changes in HRQoL. The objective of this study was to assess the correlation between changes in patient-reported outcome measures (PROMs) of signs and symptoms, dermatologic quality of life (QoL), and urticaria-specific QoL. METHODS: Latent growth models (LGMs) were applied to longitudinal data from three randomized, Phase 3 clinical trials investigating the efficacy and safety of omalizumab in CSU. RESULTS: A near-perfect association between changes in signs and symptoms and changes in dermatologic and urticaria-specific QoLs was identified in each clinical trial when using LGMs (correlation coefficient range 0.88-0.92). CONCLUSION: Evidence showed that changes in signs and symptoms are closely related to changes in HRQoL. However, analyses were performed on clinical trial results of an extremely effective treatment; a less effective treatment with much smaller changes over time may not show such close correlations. Results suggest that any of these PROMs may be used to understand changes in CSU. FAU - Stull, Donald E AU - Stull DE AD - RTI Health Solutions, Research Triangle Park, NC, USA. dstull@rti.org. FAU - McBride, Doreen AU - McBride D AD - RTI Health Solutions, Didsbury, Manchester, UK. dmcbride@rti.org. FAU - Houghton, Katherine AU - Houghton K AD - RTI Health Solutions, Research Triangle Park, NC, USA. FAU - Finlay, Andrew Y AU - Finlay AY AD - Cardiff University School of Medicine, Cardiff, UK. FAU - Gnanasakthy, Ari AU - Gnanasakthy A AD - RTI Health Solutions, Research Triangle Park, NC, USA. FAU - Balp, Maria-Magdalena AU - Balp MM AD - Novartis Pharma AG, GMA and HEOR, Basel, Switzerland. LA - eng PT - Clinical Trial, Phase III PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20160130 PL - United States TA - Adv Ther JT - Advances in therapy JID - 8611864 RN - 2P471X1Z11 (Omalizumab) MH - Adolescent MH - Adult MH - Aged MH - Child MH - Chronic Disease MH - Humans MH - Longitudinal Studies MH - Middle Aged MH - Omalizumab/*therapeutic use MH - *Patient Outcome Assessment MH - *Quality of Life MH - Severity of Illness Index MH - Treatment Outcome MH - Urticaria/*drug therapy/*psychology MH - Young Adult PMC - PMC4769726 OTO - NOTNLM OT - Correlation OT - Health-related quality of life OT - Latent growth model OT - Quality of life OT - Urticaria EDAT- 2016/02/03 06:00 MHDA- 2016/09/30 06:00 PMCR- 2016/01/30 CRDT- 2016/02/03 06:00 PHST- 2015/12/01 00:00 [received] PHST- 2016/02/03 06:00 [entrez] PHST- 2016/02/03 06:00 [pubmed] PHST- 2016/09/30 06:00 [medline] PHST- 2016/01/30 00:00 [pmc-release] AID - 10.1007/s12325-016-0282-0 [pii] AID - 282 [pii] AID - 10.1007/s12325-016-0282-0 [doi] PST - ppublish SO - Adv Ther. 2016 Feb;33(2):214-24. doi: 10.1007/s12325-016-0282-0. Epub 2016 Jan 30. PMID- 29237621 OWN - NLM STAT- MEDLINE DCOM- 20190114 LR - 20250214 IS - 1468-2060 (Electronic) IS - 0003-4967 (Print) IS - 0003-4967 (Linking) VI - 77 IP - 5 DP - 2018 May TI - Patient characteristics influence the choice of biological drug in RA, and will make non-TNFi biologics appear more harmful than TNFi biologics. PG - 650-657 LID - 10.1136/annrheumdis-2017-212395 [doi] AB - OBJECTIVES: With the wide range of biological disease-modifying anti-rheumatic drugs (bDMARDs) available for treating rheumatoid arthritis (RA), and limited evidence to guide the choice for individual patients, we wished to evaluate whether patient characteristics influence the choice of bDMARD in clinical practice, and to quantify the extent to which this would bias direct comparisons of treatment outcome. METHODS: Register-based study of all Swedish patients with RA initiating necrosis factor inhibitor (TNFi), rituximab, abatacept or tocilizumab in 2011-2015 as their first bDMARD (n=6481), or after switch from TNFi as first bDMARD (n=2829). Group differences in demographics, clinical characteristics and medical history were assessed in multivariable regression models. Predicted differences in safety and treatment outcomes were calculated as a function of patient characteristics, through regression modelling based on observed outcomes among patients with RA starting bDMARDs 2006-2010. RESULTS: Patients starting non-TNFi were older than those starting TNFi, had lower socioeconomic status, higher disease activity and higher burden of diseases including malignancy, serious infections and diabetes. Differences were most pronounced at first bDMARD initiation. These factors were linked to treatment outcome independent of therapy, yielding worse apparent safety and effectiveness for non-TNFi biologics, most extreme for rituximab. Standardising to the age/sex distribution of the TNFi group reduced differences considerably. CONCLUSIONS: There was significant channelling of older and less healthy patients with RA to non-TNFi bDMARDs, in particular as first bDMARD. Whether this channelling represents a maximised benefit/risk ratio is unclear. Unless differences in age, medical history and disease activity are accounted for, they will substantially confound non-randomised comparative studies of available bDMARDs' safety and effectiveness. CI - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. FAU - Frisell, Thomas AU - Frisell T AUID- ORCID: 0000-0002-5735-9626 AD - Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. FAU - Baecklund, Eva AU - Baecklund E AD - Rheumatology Unit, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. FAU - Bengtsson, Karin AU - Bengtsson K AUID- ORCID: 0000-0001-5154-0144 AD - Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. FAU - Di Giuseppe, Daniela AU - Di Giuseppe D AD - Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. FAU - Forsblad-d'Elia, Helena AU - Forsblad-d'Elia H AD - Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden. FAU - Askling, Johan AU - Askling J AD - Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. AD - Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden. CN - ARTIS Study group LA - eng PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171213 PL - England TA - Ann Rheum Dis JT - Annals of the rheumatic diseases JID - 0372355 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 0 (Antirheumatic Agents) RN - 0 (Biological Products) RN - 0 (Tumor Necrosis Factor-alpha) RN - 4F4X42SYQ6 (Rituximab) RN - 7D0YB67S97 (Abatacept) RN - I031V2H011 (tocilizumab) SB - IM MH - Abatacept/therapeutic use MH - Adult MH - Age Distribution MH - Aged MH - Antibodies, Monoclonal, Humanized/therapeutic use MH - Antirheumatic Agents/adverse effects/*therapeutic use MH - Arthritis, Rheumatoid/*drug therapy/psychology MH - Biological Products/adverse effects/*therapeutic use MH - *Choice Behavior MH - Drug Substitution/psychology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Registries MH - Regression Analysis MH - Risk Assessment MH - Rituximab/therapeutic use MH - Severity of Illness Index MH - Sex Distribution MH - Social Class MH - Sweden MH - Treatment Outcome MH - Tumor Necrosis Factor-alpha/antagonists & inhibitors PMC - PMC5909744 OTO - NOTNLM OT - dmards (biologic) OT - epidemiology OT - health services research OT - outcomes research OT - rheumatoid arthritis COIS- Competing interests: ARTIS has entered into agreements with Abbvie, BMS, MSD, Lilly, Pfizer, Roche, Samsung Bioepis and UCB. Companies with products mentioned in this manuscript were given a courtesy review of the manuscript before publication, but were not involved in planning the study, performing the analysis or interpreting the results. EDAT- 2017/12/15 06:00 MHDA- 2019/01/15 06:00 PMCR- 2018/04/20 CRDT- 2017/12/15 06:00 PHST- 2017/09/15 00:00 [received] PHST- 2017/11/23 00:00 [revised] PHST- 2017/11/27 00:00 [accepted] PHST- 2017/12/15 06:00 [pubmed] PHST- 2019/01/15 06:00 [medline] PHST- 2017/12/15 06:00 [entrez] PHST- 2018/04/20 00:00 [pmc-release] AID - S0003-4967(24)00897-5 [pii] AID - annrheumdis-2017-212395 [pii] AID - 10.1136/annrheumdis-2017-212395 [doi] PST - ppublish SO - Ann Rheum Dis. 2018 May;77(5):650-657. doi: 10.1136/annrheumdis-2017-212395. Epub 2017 Dec 13. PMID- 12035695 OWN - NLM STAT- MEDLINE DCOM- 20020627 LR - 20241219 IS - 0278-4807 (Print) IS - 0278-4807 (Linking) VI - 26 IP - 3 DP - 2001 May-Jun TI - Family caregiver expectations and management of the stroke trajectory. PG - 94-9 AB - Less than 20% of stroke survivors enter rehabilitation or long-term care facilities after their stroke. Stroke recovery is extremely variable and the resulting uncertainty places a heavy burden on the survivors' family caregivers. According to the trajectory framework, chronic conditions have a defined course that can be shaped and managed. This grounded theory study, part of a larger research project, explored the expectations of family caregivers of the stroke trajectory and their management strategies. Thirteen family caregivers of stroke patients in a sparsely populated area participated in semi-structured interviews. The caregivers were without ideas about what the recovery of their loved ones would be like and had difficulty making projections about the trajectory. They used several strategies, however, in attempts to manage the stroke trajectory. They constructed a positive recovery, reconstituted family life, maintained family routines, created a safety net, and redoubled self-reliance. The findings have implications for how nurses support family caregivers of stroke survivors. FAU - Burman, M E AU - Burman ME AD - School of Nursing, University of Wyoming, PO Box 3065, Laramie, WY 82071-3065, USA. mburman@uwyo.edu LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Rehabil Nurs JT - Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses JID - 8104825 MH - *Attitude to Health MH - Caregivers/*psychology MH - Chronic Disease MH - Cost of Illness MH - Family Health MH - Humans MH - Nursing Services/*standards MH - *Stroke Rehabilitation EDAT- 2002/05/31 10:00 MHDA- 2002/06/28 10:01 CRDT- 2002/05/31 10:00 PHST- 2002/05/31 10:00 [pubmed] PHST- 2002/06/28 10:01 [medline] PHST- 2002/05/31 10:00 [entrez] AID - 10.1002/j.2048-7940.2001.tb02212.x [doi] PST - ppublish SO - Rehabil Nurs. 2001 May-Jun;26(3):94-9. doi: 10.1002/j.2048-7940.2001.tb02212.x. PMID- 12076457 OWN - NLM STAT- MEDLINE DCOM- 20020809 LR - 20231113 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2002 IP - 2 DP - 2002 TI - Interventions for preventing eating disorders in children and adolescents. PG - CD002891 LID - CD002891 AB - BACKGROUND: Eating disorders represent an extremely difficult condition to treat and patients consume an enormous amount of mental health energy and resources. Being young, female, and dieting are some of the few identified risk factors that have been reliably linked to the development of eating disorders, and several prevention eating disorder prevention programs have been developed and trialed with children and adolescents. The purpose of this systematic review is to evaluate the effectiveness of eating disorder prevention programs for children and adolescents both in the general population and those determined to be at risk. OBJECTIVES: 1. To determine if eating disorder prevention programs are effective in promoting healthy eating attitudes and behaviours in children and adolescents; 2. To determine if eating disorder prevention programs are effective in promoting psychological factors that protect children and adolescents from developing eating disorders; 3. To determine if eating disorder prevention programs are effective in promoting satisfactory physical health in children and adolescents; 4. To determine if eating disorder prevention programs have a long-term, sustainable, and positive impact on the mental and physical health of children and adolescents; and, 5. To determine the safety of eating disorder prevention programs in terms of possible harmful consequences on the mental or physical health of children and adolescents. SEARCH STRATEGY: Relevant trials are identified through searching the Cochrane Controlled Trial Register (CCTR) and relevant biomedical and social science databases. All terms necessary to detect prevention programs and the participant groups are used. A strategy to locate randomised controlled trials is used. Other sources of information are the bibliographies of systematic and non-systematic reviews and reference lists from articles identified through the search strategy. In order to identify unpublished studies, experts in the field are contacted by letter and/or electronic mail. SELECTION CRITERIA: Randomised controlled trials (RCT) with a major focus on eating disorder prevention programs for children and adolescents, where there is no known DSM-IV diagnosis of an eating disorder, are eligible for inclusion in the review. Trials must include a control group and at least one objective outcome measure (eg. BMI) or a standardised psychological measure used with the intervention and control group, pre- and post-intervention. DATA COLLECTION AND ANALYSIS: A total of 1379 titles have been identified through the search to date. 13 studies were located that reported use of a randomised controlled trial methodology and were critically appraised by two independent reviewers. Five (5) studies were excluded as data were not reported in a useable form or useable data could not be obtained from the trial authors, one dissertation could not be obtained, one study had no "true" no-treatment or usual treatment control group, and one study did not use a pre-test outcome measure. Eight (8) studies met the selection criteria outlined above. MAIN RESULTS: Only one of eight pooled comparisons of two or more studies using similar outcome measures and similar intervention types demonstrated the statistically significant effect of a particular type of eating disorder prevention program for children and adolescents. Combined data from two eating disorder prevention programs based on a media literacy and advocacy approach indicate a reduction in the internalisation or acceptance of societal ideals relating to appearance at a 3- to 6-month follow-up (Kusel, unpublished; Neumark-Sztainer2000) [SMD -0.28, -0.51 to -0.05, 95% CI]. However, there is insufficient evidence to conclude that this approach also demonstrated a significant impact on awareness of societal standards relating to appearance. There is insufficient evidence to support the effect of four programs designed to address eating attitudes and behaviours and other adolescent issues on body weight, eating disorder symptoms, associated eating disorder psychopathology or general psychological and physical well-being in the general sample or those classified as being at high risk for eating disorder (Buddeberg-F 1998; Killen 1993/1996; Santonastaso 1999; Zanetti 1999). Given only one program used a psychoeducation approach to prevent bulimia nervosa (Jerome, unpublished) and only one program adopted a focus on self-esteem (O'Dea 2000), the effect of these approaches could not be evaluated via meta-analyses. In relation to potential harmful effects, there is not sufficient evidence to suggest that harm resulted from any of the prevention programs included in the review. REVIEWER'S CONCLUSIONS: The one significant pooled effect in the current review does not allow for any firm conclusions to be made about the impact of prevention programs for eating disorders in children and adolescents, although none of the pooled comparisons indicated evidence of harm. From a clinical perspective, the development and refinement of prevention programs is complicated by a lack of knowledge about risk factors associated with eating disorders and the need to strike a balance between delivering preventive interventions for eating disorders and considering the potential to cause harm. From a research perspective, the idea of "thresholds" for identifying young people at risk of developing eating disorders has been raised, and denial of concern or denial of illness represents a further issue complicating early identification in relation to eating disorder symptomatology. Longer-term effects of the intervention approaches will need to be monitored across development in order to demonstrate a decline in the incidence of eating disorders and associated risk factors. FAU - Pratt, B M AU - Pratt BM AD - Psychological Medicine, The Children's Hospital at Westmead, Locked Bag 4001, Westmead, NSW, Australia, 2145. FAU - Woolfenden, S R AU - Woolfenden SR LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM MH - Adolescent MH - Child MH - Feeding and Eating Disorders/*prevention & control/psychology MH - Humans MH - Program Evaluation MH - Psychotherapy PMC - PMC6999856 COIS- None. EDAT- 2002/06/22 10:00 MHDA- 2002/08/10 10:01 PMCR- 2003/04/22 CRDT- 2002/06/22 10:00 PHST- 2002/06/22 10:00 [pubmed] PHST- 2002/08/10 10:01 [medline] PHST- 2002/06/22 10:00 [entrez] PHST- 2003/04/22 00:00 [pmc-release] AID - CD002891 [pii] AID - 10.1002/14651858.CD002891 [doi] PST - ppublish SO - Cochrane Database Syst Rev. 2002;2002(2):CD002891. doi: 10.1002/14651858.CD002891. PMID- 39515223 OWN - NLM STAT- MEDLINE DCOM- 20241123 LR - 20241123 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 362 DP - 2024 Dec TI - Thermal comfort and gender affirmation: A virtual ethnography of extreme heat among trans women in Rio de Janeiro. PG - 117481 LID - S0277-9536(24)00935-3 [pii] LID - 10.1016/j.socscimed.2024.117481 [doi] AB - The multisensory experience of feeling hot, breathless, sweaty, and weak during heat spells among transgender people is a critically understudied area in both medical anthropology and thermal comfort research. This article contributes to the anthropology of heat and humidity by intersecting with health and thermal comfort studies. Through virtual ethnography with three trans women in Rio de Janeiro in 2021 and 2022, the research reveals that trans women in the city face heightened risks of heat stress and thermal discomfort due to unsafe living conditions, side effects of gender-affirming modifications, and social discrimination. These findings highlight the urgent need to address the specific challenges transgender individuals face in accessing thermal safety and underscore the importance of considering their unique needs. CI - Copyright © 2024 The Author. Published by Elsevier Ltd.. All rights reserved. FAU - Mazzone, Antonella AU - Mazzone A AD - University of Bristol, 43 Woodland Rd, Bristol BS8 1TH, United Kingdom. Electronic address: Antonella.mazzone@bristol.ac.uk. LA - eng PT - Journal Article DEP - 20241105 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - *Transgender Persons/psychology MH - Female MH - Brazil MH - *Anthropology, Cultural MH - Extreme Heat/adverse effects MH - Adult MH - Male OTO - NOTNLM OT - Climate change OT - Heat vulnerability OT - Sexuality OT - Thermal comfort OT - Transgender EDAT- 2024/11/13 13:53 MHDA- 2024/11/24 00:44 CRDT- 2024/11/08 18:11 PHST- 2024/05/22 00:00 [received] PHST- 2024/10/24 00:00 [revised] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/11/24 00:44 [medline] PHST- 2024/11/13 13:53 [pubmed] PHST- 2024/11/08 18:11 [entrez] AID - S0277-9536(24)00935-3 [pii] AID - 10.1016/j.socscimed.2024.117481 [doi] PST - ppublish SO - Soc Sci Med. 2024 Dec;362:117481. doi: 10.1016/j.socscimed.2024.117481. Epub 2024 Nov 5. PMID- 32880706 OWN - NLM STAT- MEDLINE DCOM- 20211015 LR - 20240801 IS - 1435-1463 (Electronic) IS - 0300-9564 (Print) IS - 0300-9564 (Linking) VI - 127 IP - 10 DP - 2020 Oct TI - Methylphenidate treatment of adult ADHD patients improves the degree of ADHD severity under routine conditions. PG - 1427-1434 LID - 10.1007/s00702-020-02226-7 [doi] AB - Attention-deficit hyperactivity disorder (ADHD) is associated with substantial personal and social impairments. Besides psychosocial interventions, current guidelines recommend a therapy with methylphenidate (MPH). This prospective, non-interventional study aims to investigate the efficacy and tolerability of MPH treatment of adult ADHD patients in a real-world setting. 468 adult patients with newly diagnosed ADHD were observed for 12-14 weeks. Primary efficacy endpoint was the clinical global impression (CGI) by the physician. Secondary endpoints comprise patient evaluation (Wender-Reimherr self-report, WR-SR), safety, tolerability, and dosage of MPH. With a mean daily dose of 35.8 (±17.0) mg MPH, the population of patients being severely/most extremely ill or markedly ill decreased by 64% and 61%, respectively. According to physicians' assessment (CGI), 74.5% of patients were identified as treatment responders. The total score of patient-based assessment (WR-SR) improved by 23.5% (50.1 ± 40.3 points) with the most profound improvement in attention deficit (-30.0%), disorganization (-26.6%), and hyperactivity / unrest (-23.3%). Self-evaluation revealed a responder rate of 35.4%. In summary, MPH treatment improves the degree of ADHD severity under routine conditions. In addition, activities of daily living were facilitated when taking MPH. The rather poor responder rates determined by patient assessment as well as the comparatively low applied mean daily dose of 35.8 mg (median 40 mg) indicate sub-optimal dosing under routine conditions, not exploiting the full beneficial therapeutic potential of MPH. FAU - Retz, Wolfgang AU - Retz W AD - Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Mainz, Mainz, Germany. FAU - Rösler, Michael AU - Rösler M AD - Institut für Gerichtliche Psychologie und Psychiatrie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Germany. FAU - Fischer, Roland AU - Fischer R AD - MEDICE Arzneimittel Pütter GmbH & Co. KG, Iserlohn, Germany. FAU - Ose, Claudia AU - Ose C AD - Institut für Medizinische Informatik, Zentrum für Klinische Studien Essen, Universitätsklinikum Essen, Biometrie und Epidemiologie, Essen, Germany. FAU - Ammer, Richard AU - Ammer R AUID- ORCID: 0000-0003-0167-4894 AD - MEDICE Arzneimittel Pütter GmbH & Co. KG, Iserlohn, Germany. richard.ammer@ukmuenster.de. AD - Klinik für Innere Medizin, Universitätsklinikum Muenster, Muenster, Germany. richard.ammer@ukmuenster.de. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200903 PL - Austria TA - J Neural Transm (Vienna) JT - Journal of neural transmission (Vienna, Austria : 1996) JID - 9702341 RN - 0 (Central Nervous System Stimulants) RN - 0 (Delayed-Action Preparations) RN - 207ZZ9QZ49 (Methylphenidate) SB - IM MH - Activities of Daily Living MH - Adult MH - *Attention Deficit Disorder with Hyperactivity/drug therapy MH - *Central Nervous System Stimulants/therapeutic use MH - Delayed-Action Preparations/therapeutic use MH - Double-Blind Method MH - Humans MH - *Methylphenidate/therapeutic use MH - Prospective Studies MH - Treatment Outcome PMC - PMC7497302 OTO - NOTNLM OT - ADHD therapy OT - Dosage OT - Efficacy OT - Methylphenidate OT - Symptoms relief OT - Tolerability EDAT- 2020/09/04 06:00 MHDA- 2021/10/16 06:00 PMCR- 2020/09/03 CRDT- 2020/09/04 06:00 PHST- 2019/11/29 00:00 [received] PHST- 2020/05/11 00:00 [accepted] PHST- 2020/09/04 06:00 [pubmed] PHST- 2021/10/16 06:00 [medline] PHST- 2020/09/04 06:00 [entrez] PHST- 2020/09/03 00:00 [pmc-release] AID - 10.1007/s00702-020-02226-7 [pii] AID - 2226 [pii] AID - 10.1007/s00702-020-02226-7 [doi] PST - ppublish SO - J Neural Transm (Vienna). 2020 Oct;127(10):1427-1434. doi: 10.1007/s00702-020-02226-7. Epub 2020 Sep 3. PMID- 26627916 OWN - NLM STAT- MEDLINE DCOM- 20161019 LR - 20180426 IS - 1365-2346 (Electronic) IS - 0265-0215 (Linking) VI - 33 IP - 3 DP - 2016 Mar TI - High rate of burnout among anaesthesiologists in Belgrade teaching hospitals: Results of a cross-sectional survey. PG - 187-94 LID - 10.1097/EJA.0000000000000383 [doi] AB - BACKGROUND: Decisions by anaesthesiologists directly impact the treatment, safety, recovery and quality of life of patients. Physical or mental collapse due to overwork or stress (burnout) in anaesthesiologists may, therefore, be expected to negatively affect patients, departments, healthcare facilities and families. OBJECTIVES: To evaluate the prevalence of burnout among anaesthesiologists in Belgrade public teaching hospitals. DESIGN: A cross-sectional survey. SETTING: Anaesthesiologists in 10 Belgrade teaching hospitals. MAIN OUTCOME MEASURES: Burnout was assessed using Maslach Burnout Inventory-Human Services Survey. RESULTS: The response rate was 76.2% (205/272) with the majority of respondents women (70.7%). The prevalence of total burnout among anaesthesiologists in Belgrade teaching hospitals was 6.34%. Measured level of burnout as assessed by high emotional exhaustion, high depersonalisation and low personal accomplishment was 52.7, 12.2 and 28.8%, respectively. More than a quarter of the studied population responded in each category with symptoms of moderate burnout. We detected that sex, additional academic education, marital status and working conditions were risk factors for emotional exhaustion and depersonalisation. Ageing increased the likelihood of burnout by 21.3% with each additional year. Shorter professional experience and increased educational accomplishment increased the risk of total burnout by 272%. CONCLUSION: Burnout rates in Belgrade teaching hospitals among anaesthesiologists are higher than in foreign hospitals. Emotional and/or physical breakdowns can have serious effects when these individuals care for patients in extremely stressed situations that may occur perioperatively. Causes for burnout should be examined more closely and means implemented to reverse this process. FAU - Milenović, Miodrag AU - Milenović M AD - From the Center for Anesthesiology and Resuscitation, Emergency Center, Clinical Center of Serbia (MM, NP); Institute of Social Medicine, School of Medicine, University of Belgrade, Serbia (BM); Department of Statistics and Mathematics, Faculty of Economics, University of Belgrade, Serbia (VV); Icahn School of Medicine at Mount Sinai, New York, USA (EF); and University Children's Hospital, School of Medicine, University of Belgrade, Serbia (DS). FAU - Matejić, Bojana AU - Matejić B FAU - Vasić, Vladimir AU - Vasić V FAU - Frost, Elizabeth AU - Frost E FAU - Petrović, Nataša AU - Petrović N FAU - Simić, Dušica AU - Simić D LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Eur J Anaesthesiol JT - European journal of anaesthesiology JID - 8411711 SB - IM CIN - Eur J Anaesthesiol. 2017 Jul;34(7):480-482. doi: 10.1097/EJA.0000000000000573. PMID: 28582365 MH - Adult MH - Anesthesiology/*trends MH - Burnout, Professional/diagnosis/epidemiology/*psychology MH - Cross-Sectional Studies MH - Female MH - Hospitals, Teaching/*trends MH - Humans MH - Male MH - Middle Aged MH - Physicians/*psychology/*trends MH - Serbia/epidemiology MH - Stress, Psychological/diagnosis/epidemiology/*psychology EDAT- 2015/12/03 06:00 MHDA- 2016/11/12 06:00 CRDT- 2015/12/03 06:00 PHST- 2015/12/03 06:00 [entrez] PHST- 2015/12/03 06:00 [pubmed] PHST- 2016/11/12 06:00 [medline] AID - 10.1097/EJA.0000000000000383 [doi] PST - ppublish SO - Eur J Anaesthesiol. 2016 Mar;33(3):187-94. doi: 10.1097/EJA.0000000000000383. PMID- 27402077 OWN - NLM STAT- MEDLINE DCOM- 20170901 LR - 20181202 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 16 DP - 2016 Jul 11 TI - Workers' perceptions of climate change related extreme heat exposure in South Australia: a cross-sectional survey. PG - 549 LID - 10.1186/s12889-016-3241-4 [doi] LID - 549 AB - BACKGROUND: Occupational exposure to extreme heat without sufficient protection may not only increase the risk of heat-related illnesses and injuries but also compromise economic productivity. With predictions of more frequent and intense bouts of hot weather, workplace heat exposure is presenting a growing challenge to workers' health and safety. This study aims to investigate workers' perceptions and behavioural responses towards extreme heat exposure in a warming climate. METHODS: A cross-sectional questionnaire survey was conducted in 2012 in South Australia among selected outdoor industries. Workers' heat risk perceptions were measured in the following five aspects: concerns about heat exposure, attitudes towards more training, policy and guideline support, the adjustment of work habits, and degree of satisfaction of current preventive measures. Bivariate and multivariate logistic regression analyses were used to identify factors significantly associated with workers' heat perceptions. RESULTS: A total of 749 respondents participated in this survey, with a response rate of 50.9 %. A little more than half (51.2 %) of respondents were moderately or very much concerned about workplace heat exposure. Factors associated with workers' heat concerns included age, undertaking very physically demanding work, and the use of personal protective equipment, heat illness history, and injury experience during hot weather. Less than half (43.4 %) of the respondents had received heat-related training. Workers aged 25-54 years and those with previous heat-related illness/injury history showed more supportive attitudes towards heat-related training. The provision of cool drinking water was the most common heat prevention measure. A little more than half (51.4 %) of respondents were satisfied with the current heat prevention measures. About two-thirds (63.8 %) of respondents agreed that there should be more heat-related regulations and guidelines for working during very hot weather. More than two-thirds (68.8 %) of the respondents were willing to adjust their current work habits to adapt to the likely increasing extreme heat, especially those with previous heat illness experience. CONCLUSIONS: The findings suggest a need to strengthen workers' heat risk awareness and refine current heat prevention strategies in a warming climate. Further heat educational programmes and training should focus on those undertaking physically demanding work outdoors, in particular young workers and those over 55 years with low education levels. FAU - Xiang, Jianjun AU - Xiang J AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. AD - Department of Emergency Response and Preparedness, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, 350001, China. FAU - Hansen, Alana AU - Hansen A AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. FAU - Pisaniello, Dino AU - Pisaniello D AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. FAU - Bi, Peng AU - Bi P AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. peng.bi@adelaide.edu.au. LA - eng PT - Journal Article DEP - 20160711 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adult MH - Age Factors MH - *Climate Change MH - Cross-Sectional Studies MH - Extreme Heat/*adverse effects MH - Female MH - Heat Stress Disorders/*prevention & control/psychology MH - Humans MH - Male MH - Middle Aged MH - Occupational Exposure/legislation & jurisprudence/*statistics & numerical data MH - Occupational Health/legislation & jurisprudence/*statistics & numerical data MH - Safety MH - South Australia MH - Workplace/legislation & jurisprudence/*psychology/statistics & numerical data MH - Young Adult PMC - PMC4940878 OTO - NOTNLM OT - Climate change OT - Heat stress OT - Perceptions OT - Work-related injuries OT - Workplace heat exposure EDAT- 2016/07/13 06:00 MHDA- 2017/09/02 06:00 PMCR- 2016/07/11 CRDT- 2016/07/13 06:00 PHST- 2016/01/08 00:00 [received] PHST- 2016/06/15 00:00 [accepted] PHST- 2016/07/13 06:00 [entrez] PHST- 2016/07/13 06:00 [pubmed] PHST- 2017/09/02 06:00 [medline] PHST- 2016/07/11 00:00 [pmc-release] AID - 10.1186/s12889-016-3241-4 [pii] AID - 3241 [pii] AID - 10.1186/s12889-016-3241-4 [doi] PST - epublish SO - BMC Public Health. 2016 Jul 11;16:549. doi: 10.1186/s12889-016-3241-4. PMID- 36781160 OWN - NLM STAT- MEDLINE DCOM- 20240530 LR - 20250128 IS - 1098-8785 (Electronic) IS - 0735-1631 (Print) IS - 0735-1631 (Linking) VI - 41 IP - S 01 DP - 2024 May TI - Perinatal Outcomes during versus Prior to the COVID-19 Pandemic and the Role of Maternal Depression and Perceived Stress: A Report from the ECHO Program. PG - e1404-e1420 LID - 10.1055/a-2033-5610 [doi] AB - OBJECTIVE: We sought to evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on perinatal outcomes while accounting for maternal depression or perceived stress and to describe COVID-specific stressors, including changes in prenatal care, across specific time periods of the pandemic. STUDY DESIGN: Data of dyads from 41 cohorts from the National Institutes of Health Environmental influences on Child Health Outcomes Program (N = 2,983) were used to compare birth outcomes before and during the pandemic (n = 2,355), and a partially overlapping sample (n = 1,490) responded to a COVID-19 questionnaire. Psychosocial stress was defined using prenatal screening for depression and perceived stress. Propensity-score matching and general estimating equations with robust variance estimation were used to estimate the pandemic's effect on birth outcomes. RESULTS: Symptoms of depression and perceived stress during pregnancy were similar prior to and during the pandemic, with nearly 40% of participants reporting mild to severe stress, and 24% reporting mild depression to severe depression. Gestations were shorter during the pandemic (B =  - 0.33 weeks, p = 0.025), and depression was significantly associated with shortened gestation (B =  - 0.02 weeks, p = 0.015) after adjustment. Birth weights were similar (B =  - 28.14 g, p = 0.568), but infants born during the pandemic had slightly larger birth weights for gestational age at delivery than those born before the pandemic (B = 0.15 z-score units, p = 0.041). More women who gave birth early in the pandemic reported being moderately or extremely distressed about changes to their prenatal care and delivery (45%) compared with those who delivered later in the pandemic. A majority (72%) reported somewhat to extremely negative views of the impact of COVID-19 on their life. CONCLUSION: In this national cohort, we detected no effect of COVID-19 on prenatal depression or perceived stress. However, experiencing the COVID-19 pandemic in pregnancy was associated with decreases in gestational age at birth, as well as distress about changes in prenatal care early in the pandemic. KEY POINTS: · COVID-19 was associated with shortened gestations.. · Depression was associated with shortened gestations.. · However, stress during the pandemic remained unchanged.. · Most women reported negative impacts of the pandemic.. CI - Thieme. All rights reserved. FAU - McKee, Kimberly S AU - McKee KS AD - Department of Family Medicine, University of Michigan, Ann Arbor, Michigan. FAU - Tang, Xiaodan AU - Tang X AD - Department of Medical Social Sciences, Northwestern University, Chicago, Illinois. FAU - Tung, Irene AU - Tung I AD - Department of Psychology, California State University Dominguez Hills, Carson, California. FAU - Wu, Guojing AU - Wu G AD - Department of Epidemology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Alshawabkeh, Akram N AU - Alshawabkeh AN AD - Department of Civil and Environmental Engineering, College of Engineering, Northeastern University, Boston, Massachusetts. FAU - Arizaga, Jessica A AU - Arizaga JA AD - Department of Psychiatry and Behavioral Sciences, University of California-San Francisco, San Francisco, California. FAU - Bastain, Theresa M AU - Bastain TM AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California. FAU - Brennan, Patricia A AU - Brennan PA AD - Department of Psychology, Emory University, Atlanta, Georgia. FAU - Breton, Carrie V AU - Breton CV AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California. FAU - Camargo, Carlos A Jr AU - Camargo CA Jr AD - Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Cioffi, Camille C AU - Cioffi CC AD - Prevention Science Institute, University of Oregon, Eugene, Oregon. FAU - Cordero, Jose F AU - Cordero JF AD - Department of Epidemiology and Biostatistics, College of Public Health, Athens, Georgia. FAU - Dabelea, Dana AU - Dabelea D AD - Department of Epidemiology, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Deutsch, Arielle R AU - Deutsch AR AD - Department of Pediatrics, Avera Research Institute, University of South Dakota School of Medicine, Sioux Falls, South Dakota. FAU - Duarte, Cristiane S AU - Duarte CS AD - Department of Psychiatry, Columbia University-NYSPI, New York, New York. FAU - Dunlop, Anne L AU - Dunlop AL AD - Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia. FAU - Elliott, Amy J AU - Elliott AJ AD - Department of Pediatrics, Avera Research Institute, University of South Dakota School of Medicine, Sioux Falls, South Dakota. FAU - Ferrara, Assiamira AU - Ferrara A AD - Division of Research, Kaiser Permanente Northern California, Oakland, California. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine, Lebanon, New Hampshire. FAU - Lester, Barry AU - Lester B AD - Center for the Study of Children at Risk, Brown University, Providence, Rhode Island. FAU - McEvoy, Cindy T AU - McEvoy CT AD - Department of Pediatrics, MCR Oregon Health and Science University, Portland, Oregon. FAU - Meeker, John AU - Meeker J AD - University of Michigan, Environmental Health Sciences, Global Public Health, Ann Arbor, Michigan. FAU - Neiderhiser, Jenae M AU - Neiderhiser JM AD - Department of Psychology, Pennsylvania State University, University Park, Pennsylvania. FAU - Herbstman, Julie AU - Herbstman J AD - Columbia Mailman School of Public Health, Environmental Health Sciences, New York, New York. FAU - Trasande, Leonardo AU - Trasande L AD - Department of Pediatrics, New York University, New York. AD - Department of Environmental Medicine, and Population Health, New York University Grossman School of Medicine and New York University School of Global Public Health, New York University, New York. FAU - O'Connor, Thomas G AU - O'Connor TG AD - Departments of Psychiatry, Psychology, Neuroscience, and Obstetrics and Gynecology, University of Rochester, Rochester, New York. FAU - Hipwell, Alison E AU - Hipwell AE AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. FAU - Comstock, Sarah S AU - Comstock SS AD - Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan. CN - program collaborators for Environmental influences on Child Health Outcomes LA - eng GR - UH3OD023253/Camargo/ GR - UH3 OD023285/OD/NIH HHS/United States GR - UH3OD023287/Breton/ GR - UH3OD023275/Karagas/ GR - UH3 OD023271/OD/NIH HHS/United States GR - UH3 OD023282/OD/NIH HHS/United States GR - UH3OD023318/Dunlop/ GR - UH3OD023289/Ferrara/ GR - UH3 OD023305/OD/NIH HHS/United States GR - UH3 OD023288/OD/NIH HHS/United States GR - UH3OD023347/Lester/ GR - UH3 OD023349/OD/NIH HHS/United States GR - U24 OD023382/OD/NIH HHS/United States GR - UH3 OD023313/OD/NIH HHS/United States GR - UH3OD023271/Karr/ GR - UH3 OD023289/OD/NIH HHS/United States GR - U2COD023375/Coordinating Center/ GR - T32 MH018261/MH/NIMH NIH HHS/United States GR - UH3 OD023249/OD/NIH HHS/United States GR - UH3 OD023389/OD/NIH HHS/United States GR - UH3 OD023290/OD/NIH HHS/United States GR - U2C OD023375/OD/NIH HHS/United States GR - P50 DA048756/DA/NIDA NIH HHS/United States GR - UH3 OD023275/OD/NIH HHS/United States GR - UH3OD023279/Elliott/ GR - P30 ES001247/ES/NIEHS NIH HHS/United States GR - UH3OD023248/Dabelea/ GR - UH3 OD023318/OD/NIH HHS/United States GR - UH3OD023313/Deoni/ GR - UH3 OD023248/OD/NIH HHS/United States GR - UH3 OD023287/OD/NIH HHS/United States GR - UH3OD023305/Trasande/ GR - UG3 OD023389/OD/NIH HHS/United States GR - K01 MH123505/MH/NIMH NIH HHS/United States GR - U24 OD023319/OD/NIH HHS/United States GR - UH3OD023328/Duarte/ GR - UH3OD023282/Gern/ GR - UH3 OD023253/OD/NIH HHS/United States GR - UH3OD023272/Schantz/ GR - UH3 OD023272/OD/NIH HHS/United States GR - UH3OD023288/McEvoy/ GR - U24OD023319/PRO Core/ GR - UH3OD023244/Hipwell/ GR - UH3OD023320/Aschner/ GR - UH3 OD023347/OD/NIH HHS/United States GR - UH3 OD023251/OD/NIH HHS/United States GR - UH3 OD023279/OD/NIH HHS/United States GR - UH3OD023389/Leve/ GR - UH3OD023337/Wright/ GR - U24OD023382/Data Analysis Center/ GR - UH3OD023290/Herbstman/ GR - UH3 OD023244/OD/NIH HHS/United States GR - UH3 OD023320/OD/NIH HHS/United States GR - UH3OD023251/Alshawabkeh/ GR - UH3OD023285/Kerver/ GR - UH3 OD023337/OD/NIH HHS/United States GR - UH3OD023249/Stanford/ GR - UH3OD023349/O‧Connor/ GR - UH3 OD023328/OD/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230213 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *COVID-19/psychology/epidemiology MH - *Stress, Psychological/epidemiology MH - Adult MH - *Depression/epidemiology MH - *Prenatal Care MH - *Pregnancy Outcome/epidemiology MH - SARS-CoV-2 MH - Pregnancy Complications/psychology/epidemiology MH - Infant, Newborn MH - United States/epidemiology MH - Gestational Age PMC - PMC11195909 MID - NIHMS1998365 COIS- C.M. served as Chair of the Data Safety Monitoring Board (DSMB) for an Aerogen-supported trial: A Partially-Blind, Randomized, Controlled, Parallel-Group Dose Ranging Study to Determine the Efficacy, Safety and Tolerability of AeroFactTM (SF-RI 1 surfactant for inhalation combined with a dedicated drug delivery system) in Preterm Infants at Risk for Worsening Respiratory Distress Syndrome; Chair of the DSMB for the NIH RCT evaluating Sildenafil in Preterm Infants with Pulmonary Hypertension. J.N. served on the Advisory Board for the Twin Life Study (Germany); received royalties or licenses from Macmillan and consulting fees from the University of Southern California. J.H. served on the New York State Drinking Water Quality Council. The other authors have no conflicts of interest to disclose. EDAT- 2023/02/14 06:00 MHDA- 2024/05/30 06:35 PMCR- 2024/06/24 CRDT- 2023/02/13 19:33 PHST- 2024/05/30 06:35 [medline] PHST- 2023/02/14 06:00 [pubmed] PHST- 2023/02/13 19:33 [entrez] PHST- 2024/06/24 00:00 [pmc-release] AID - 10.1055/a-2033-5610 [doi] PST - ppublish SO - Am J Perinatol. 2024 May;41(S 01):e1404-e1420. doi: 10.1055/a-2033-5610. Epub 2023 Feb 13. PMID- 26028181 OWN - NLM STAT- MEDLINE DCOM- 20160517 LR - 20150817 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 11 IP - 4 DP - 2015 Aug TI - Self-cathing experience journal: Enhancing the patient and family experience in clean intermittent catheterization. PG - 187.e1-6 LID - S1477-5131(15)00113-8 [pii] LID - 10.1016/j.jpurol.2015.03.011 [doi] AB - OBJECTIVE: This pilot study evaluated the safety, feasibility, and usefulness of the Self-Cathing Experience Journal (SC-EJ), an online resource for patients and families to address issues and stigma surrounding clean intermittent catheterization (CIC). Modeled after previous assessments of the Cardiac and Depression Experience Journals (EJs), this project uniquely included patients and caregivers. We explored whether patients and caregivers would find the SC-EJ helpful in increasing their understanding of CIC, accepting the medical benefits of self-catheterization, improving hopefulness, and diminishing social isolation. METHODS: Patients seen in a tertiary urology clinic were asked to view the SC-EJ for 30 min and rate its safety and efficacy. The cross-sectional sample included 25 families: 17 surveys were completed by the patient and their caregiver, five by the patient only, and three by the caregiver only. Mean patient age was 15.7 ± 5.8 years (range 7-29 years). The patients were 64% female, and 72% used CIC due to neurological diagnoses. RESULTS: Mean overall patient satisfaction with the SC-EJ was moderately high (mean = 5, out of a 7-point Likert scale from 1 = not at all to 7 = extremely). Mean overall caregiver satisfaction was high (mean = 5.55) and was similar to caregiver satisfaction scores recorded in caregivers with children with congenital heart disease and depression (mean = 5.7 and mean = 5.75, respectively). No significant differences were noted in satisfaction between CIC patients and CIC caregivers or among caregivers of the three populations surveyed (CIC, Cardiac, and Depression). CIC patients and caregivers reported that SC-EJ viewing gave them a strong sense that others are facing similar issues (patient mean = 6.15, caregiver mean = 6.21) and that it was helpful to read about other families' CIC experiences (patient mean = 6, caregiver mean = 5.89). DISCUSSION: The SC-EJ appears to be safe, feasible, and useful to patients and families using CIC. Ratings from caregivers of CIC patients were similar to other cohorts of caregivers facing chronic childhood conditions. Despite beliefs that the EJ format best targets adults, high satisfaction ratings among patients suggest that the SC-EJ is acceptable and beneficial to children and adolescents. This web-based intervention can be a helpful clinical supplement in promoting healthy coping skills and a decreased sense of isolation among patients and families facing CIC. The unique integration of real patient and family experiences with accurate and vetted medical knowledge has the potential to enhance resiliency among viewers who use CIC. CI - Copyright © 2015 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Holland, Jennifer E AU - Holland JE AD - Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. FAU - DeMaso, David R AU - DeMaso DR AD - Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. Electronic address: david.demaso@childrens.harvard.edu. FAU - Rosoklija, Ilina AU - Rosoklija I AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Johnson, Kathryn L AU - Johnson KL AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Manning, Diane AU - Manning D AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Bellows, Alexandra L AU - Bellows AL AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Bauer, Stuart B AU - Bauer SB AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150421 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM CIN - J Urol. 2016 Jun;195(6):1884. doi: 10.1016/j.juro.2016.03.021. PMID: 27191113 MH - *Adaptation, Psychological MH - Adolescent MH - Adult MH - Child MH - Cross-Sectional Studies MH - Feasibility Studies MH - Female MH - Humans MH - Intermittent Urethral Catheterization/methods/*psychology MH - Male MH - Patient Compliance/psychology MH - Patient Education as Topic/*methods MH - *Patient Satisfaction MH - Pilot Projects MH - *Quality of Life MH - *Self Concept MH - Social Adjustment MH - Urinary Bladder, Neurogenic/*psychology/therapy MH - Young Adult OTO - NOTNLM OT - Bladder dysfunction OT - Clean intermittent catheterization OT - Patient education OT - Patient satisfaction OT - Pediatric urology EDAT- 2015/06/02 06:00 MHDA- 2016/05/18 06:00 CRDT- 2015/06/02 06:00 PHST- 2014/12/29 00:00 [received] PHST- 2015/03/17 00:00 [accepted] PHST- 2015/06/02 06:00 [entrez] PHST- 2015/06/02 06:00 [pubmed] PHST- 2016/05/18 06:00 [medline] AID - S1477-5131(15)00113-8 [pii] AID - 10.1016/j.jpurol.2015.03.011 [doi] PST - ppublish SO - J Pediatr Urol. 2015 Aug;11(4):187.e1-6. doi: 10.1016/j.jpurol.2015.03.011. Epub 2015 Apr 21. PMID- 29990359 OWN - NLM STAT- MEDLINE DCOM- 20190409 LR - 20230926 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 15 IP - 7 DP - 2018 Jul TI - Reduced cognitive function during a heat wave among residents of non-air-conditioned buildings: An observational study of young adults in the summer of 2016. PG - e1002605 LID - 10.1371/journal.pmed.1002605 [doi] LID - e1002605 AB - BACKGROUND: In many regions globally, buildings designed for harnessing heat during the cold exacerbate thermal exposures during heat waves (HWs) by maintaining elevated indoor temperatures even when high ambient temperatures have subdued. While previous experimental studies have documented the effects of ambient temperatures on cognitive function, few have observed HW effects on indoor temperatures following subjects' habitual conditions. The objective was to evaluate the differential impact of having air conditioning (AC) on cognitive function during a HW among residents of AC and non-AC buildings using a prospective observational cohort study. METHODS: We followed 44 students (mean age = 20.2 years; SD = 1.8 years) from a university in the Greater Boston area, Massachusetts in the United States living in AC (n = 24) and non-AC (n = 20) buildings before, during, and after a HW. Two cognition tests were self-administered daily for a period of 12 days (July 9-July 20, 2016), the Stroop color-word test (STROOP) to assess selective attention/processing speed and a 2-digit, visual addition/subtraction test (ADD) to evaluate cognitive speed and working memory. The effect of the HW on cognitive function was evaluated using difference-in-differences (DiD) modelling. FINDINGS: Mean indoor temperatures in the non-AC group (mean = 26.3°C; SD = 2.5°C; range = 19.6-30.4°C) were significantly higher (p < 0.001) than in the AC group (mean = 21.4°C; SD = 1.9°C; range = 17.5-25.0°C). DiD estimates show an increase in reaction time (STROOP = 13.4%, p < 0001; ADD = 13.3%, p < 0.001) and reduction in throughput (STROOP = -9.9%, p < 0.001; ADD = -6.3%, p = 0.08) during HWs among non-AC residents relative to AC residents at baseline. While ADD showed a linear relationship with indoor temperatures, STROOP was described by a U-shaped curve with linear effects below and above an optimum range (indoor temperature = 22°C-23°C), with an increase in reaction time of 16 ms/°C and 24 ms/°C for STROOP and ADD, respectively. Cognitive tests occurred right after waking, so the study is limited in that it cannot assess whether the observed effects extended during the rest of the day. Although the range of students' ages also represents a limitation of the study, the consistent findings in this young, healthy population might indicate that greater portions of the population are susceptible to the effects of extreme heat. CONCLUSIONS: Cognitive function deficits resulting from indoor thermal conditions during HWs extend beyond vulnerable populations. Our findings highlight the importance of incorporating sustainable adaptation measures in buildings to preserve educational attainment, economic productivity, and safety in light of a changing climate. FAU - Cedeño Laurent, Jose Guillermo AU - Cedeño Laurent JG AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Williams, Augusta AU - Williams A AUID- ORCID: 0000-0002-1496-8931 AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Oulhote, Youssef AU - Oulhote Y AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Zanobetti, Antonella AU - Zanobetti A AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Allen, Joseph G AU - Allen JG AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. FAU - Spengler, John D AU - Spengler JD AD - Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20180710 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Adolescent MH - Adult MH - Age Factors MH - *Air Conditioning MH - Attention MH - Boston/epidemiology MH - *Cognition MH - Cognition Disorders/diagnosis/*epidemiology/prevention & control/psychology MH - *Facility Design and Construction MH - Female MH - Hot Temperature/*adverse effects MH - Humans MH - Male MH - Memory, Short-Term MH - Prospective Studies MH - Risk Factors MH - *Seasons MH - Stroop Test MH - Students/psychology MH - Time Factors MH - Young Adult PMC - PMC6039003 COIS- The authors have declared that no competing interests exist. EDAT- 2018/07/11 06:00 MHDA- 2019/04/10 06:00 PMCR- 2018/07/10 CRDT- 2018/07/11 06:00 PHST- 2018/02/09 00:00 [received] PHST- 2018/06/08 00:00 [accepted] PHST- 2018/07/11 06:00 [entrez] PHST- 2018/07/11 06:00 [pubmed] PHST- 2019/04/10 06:00 [medline] PHST- 2018/07/10 00:00 [pmc-release] AID - PMEDICINE-D-18-00593 [pii] AID - 10.1371/journal.pmed.1002605 [doi] PST - epublish SO - PLoS Med. 2018 Jul 10;15(7):e1002605. doi: 10.1371/journal.pmed.1002605. eCollection 2018 Jul. PMID- 21196446 OWN - NLM STAT- MEDLINE DCOM- 20120106 LR - 20211020 IS - 1522-9645 (Electronic) IS - 0195-668X (Print) IS - 0195-668X (Linking) VI - 32 IP - 8 DP - 2011 Apr TI - Stock volatility as a risk factor for coronary heart disease death. PG - 1006-11 LID - 10.1093/eurheartj/ehq495 [doi] AB - AIMS: The volatility of financial markets may cause substantial emotional and physical stress among investors. We hypothesize that this may have adverse effects on cardiovascular health. The Chinese stock markets were extremely volatile between 2006 and 2008. We, therefore, examined the relationship between daily change of the Shanghai Stock Exchange (SSE) Composite Index (referred as the Index) and coronary heart disease (CHD) deaths from 1 January 2006 to 31 December 2008 in Shanghai, the financial capital of China. METHODS AND RESULTS: Daily death and stock performance data were collected from the Shanghai Center for Disease Control and Prevention and SSE, respectively. Data were analysed with over-dispersed generalized linear Poisson models, controlling for long-term and seasonal trends of CHD mortality, day of the week, Index closing value, weather conditions, and air pollution levels. We observed a U-shaped relationship between the Index change and CHD deaths: both rising and falling of the Index were associated with more deaths and the fewest deaths coincided with little or no change of the index. We also examined the absolute daily change of the Index in relation to CHD deaths: in a 1-day lag model, each 100-point change of the Index corresponded to 5.17% (95% confidence interval: 1.71, 8.63%) increase in CHD deaths. Further analysis showed that the association was stronger for out-of-hospital CHD death than for in-hospital death. CONCLUSION: We found that CHD deaths fluctuated with daily stock changes in Shanghai, suggesting that stock volatility may adversely affect cardiovascular health. FAU - Ma, Wenjuan AU - Ma W AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China. FAU - Chen, Honglei AU - Chen H FAU - Jiang, Lili AU - Jiang L FAU - Song, Guixiang AU - Song G FAU - Kan, Haidong AU - Kan H LA - eng GR - Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20101231 PL - England TA - Eur Heart J JT - European heart journal JID - 8006263 SB - IM MH - Adult MH - Aged MH - Cause of Death MH - China/epidemiology MH - Coronary Disease/economics/*mortality/psychology MH - Female MH - Humans MH - Investments/*statistics & numerical data MH - Male MH - Middle Aged MH - Risk Factors MH - Stress, Psychological/economics/*mortality MH - Urban Health PMC - PMC3076666 EDAT- 2011/01/05 06:00 MHDA- 2012/01/10 06:00 PMCR- 2012/04/01 CRDT- 2011/01/04 06:00 PHST- 2011/01/04 06:00 [entrez] PHST- 2011/01/05 06:00 [pubmed] PHST- 2012/01/10 06:00 [medline] PHST- 2012/04/01 00:00 [pmc-release] AID - ehq495 [pii] AID - 10.1093/eurheartj/ehq495 [doi] PST - ppublish SO - Eur Heart J. 2011 Apr;32(8):1006-11. doi: 10.1093/eurheartj/ehq495. Epub 2010 Dec 31. PMID- 29672843 OWN - NLM STAT- MEDLINE DCOM- 20190625 LR - 20220408 IS - 1466-7657 (Electronic) IS - 0020-8132 (Linking) VI - 66 IP - 1 DP - 2019 Mar TI - Challenges faced in rural hospitals: the experiences of nurse managers in Uganda. PG - 70-77 LID - 10.1111/inr.12459 [doi] AB - AIM: The aim of this study was to understand nurse ward managers perceived challenges in the rural healthcare setting in Uganda. BACKGROUND: The health workforce, essential medicines and equipment and political unrest are the main factors affecting the international community in addressing the hefty disease burden in World Health Organization African regions. Nurse ward managers have an important role to play to mitigate these factors in health facilities in these regions through leadership, supervision and support for staff. METHODS: This study utilized interpretive phenomenology based on Gadamer's hermeneutical principles. Eleven nurse managers from two rural public hospitals in Uganda were interviewed. Those with more than a 2-year experience in their management role were invited to participate in the study. RESULTS: Nurse managers pointed out four major challenges with staffing, while they worked in the rural healthcare settings. These are summarized into themes: 'Numbers do matter'; 'I cannot access them when I need them at work'; 'Challenges in dealing with negative attitudes'; and 'Questioning own ability to manage health services'. DISCUSSION: Health facilities in rural areas face extremely low staff-to-patient ratio, a high level of workload, lack of essential medicines and equipment, low salaries and delayed payment for staff. CONCLUSION: Nurse managers demonstrated situation-based performance to minimize the impact of these challenges on the quality and safety of patient care, but they had less influence on policy and resource development. IMPLICATIONS FOR NURSING POLICY: It is imperative to mobilize education for nurse ward managers to enable them to improve leadership, management skills and to have a greater impact on policy and resource development. CI - © 2018 International Council of Nurses. FAU - Kakyo, T A AU - Kakyo TA AD - Department of Nursing and Midwifery, Muni University, Arua, Uganda. FAU - Xiao, L D AU - Xiao LD AD - College of Nursing and Health Sciences, Flinders University, Adelaide, SA, Australia. LA - eng GR - Australia Awards under Department of Foreign Affairs and Trade/ PT - Journal Article DEP - 20180419 PL - England TA - Int Nurs Rev JT - International nursing review JID - 7808754 SB - IM MH - Adult MH - *Attitude of Health Personnel MH - Female MH - Hospitals, Rural/*organization & administration MH - Humans MH - *Job Satisfaction MH - Male MH - Middle Aged MH - Nurse Administrators/*psychology MH - *Professional Role MH - Uganda OTO - NOTNLM OT - Human Resources for Health OT - Nurse Ward Managers OT - Nursing Staff OT - Quality of Care OT - Rural Hospitals OT - Staffing Challenges OT - Uganda EDAT- 2018/04/20 06:00 MHDA- 2019/06/27 06:00 CRDT- 2018/04/20 06:00 PHST- 2018/04/20 06:00 [pubmed] PHST- 2019/06/27 06:00 [medline] PHST- 2018/04/20 06:00 [entrez] AID - 10.1111/inr.12459 [doi] PST - ppublish SO - Int Nurs Rev. 2019 Mar;66(1):70-77. doi: 10.1111/inr.12459. Epub 2018 Apr 19. PMID- 33303405 OWN - NLM STAT- MEDLINE DCOM- 20210505 LR - 20210505 IS - 2468-0869 (Electronic) IS - 2468-0451 (Print) IS - 2468-0451 (Linking) VI - 26 IP - 2 DP - 2021 May TI - Air travel in a COVID-19 world: Commercial airline passengers' health concerns and attitudes towards infection prevention and disease control measures. PG - 110-117 LID - S2468-0451(20)30086-9 [pii] LID - 10.1016/j.idh.2020.11.002 [doi] AB - BACKGROUND: COVID-19 and its associated travel bans have reduced international passenger traffic by over 80% below 2019 levels. If airlines are to resume flying at commercially sustainable levels, they must work to restore passengers confidence and sense of security. This study examined commercial airline passengers' health concerns and attitudes towards infection prevention and control measures for travel health and safety in the current COVID-19 global pandemic. METHODS: A cross-sectional study was conducted inviting adult members of 39 frequent flyer groups across three social media platforms to participate in an online survey. RESULTS: A total of 205 respondents completed the survey. The majority (75.6%) reported feeling 'somewhat' to 'extremely concerned' about contracting an infectious disease while flying, particularly respiratory-related. Few (9.8%) reported perceiving their health as an 'essential priority' for their preferred airline. Most respondents agreed airlines should provide complimentary hand sanitisers (86.8%), sanitary wipes (82.9%) and masks (64.4%) for passengers to use while flying as well as more information about preventing the spread of infections (90.7%), which would make the majority feel safer to fly. CONCLUSION: COVID-19 has extensively challenged the air travel industry. Passengers have signalled that they expect more from airlines, and that they would actively engage in additional infection prevention and disease control measures while flying. Airlines must ensure passengers about the steps taken to minimize travel-associated risks, and their commitment towards passengers' health and wellbeing, in order to rebuild consumers' confidence in the recovery of the air travel industry. CI - Copyright © 2020 Australasian College for Infection Prevention and Control. Published by Elsevier B.V. All rights reserved. FAU - Sotomayor-Castillo, Cristina AU - Sotomayor-Castillo C AD - Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Camperdown, NSW, Australia. Electronic address: cristina.sotomayor@sydney.edu.au. FAU - Radford, Kaitlyn AU - Radford K AD - Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia. FAU - Li, Cecilia AU - Li C AD - Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Camperdown, NSW, Australia. Electronic address: https://twitter.com/@CeciliaZj_Li. FAU - Nahidi, Shizar AU - Nahidi S AD - Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Camperdown, NSW, Australia. FAU - Shaban, Ramon Z AU - Shaban RZ AD - Faculty of Medicine and Health, Susan Wakil School of Nursing and Midwifery, University of Sydney, Camperdown, NSW, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Camperdown, NSW, Australia; New South Wales Biocontainment Centre and the Department of Infection Prevention and Control, Division of Infectious Diseases and Sexual Health, Westmead Hospital & Western Sydney Local Health District, Westmead, NSW, Australia. Electronic address: ramon.shaban@sydney.edu.au. LA - eng PT - Journal Article PT - Observational Study DEP - 20201119 PL - Netherlands TA - Infect Dis Health JT - Infection, disease & health JID - 101689703 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Air Travel/*psychology MH - *Attitude MH - COVID-19/*prevention & control MH - Cross-Sectional Studies MH - Female MH - Humans MH - Male MH - Middle Aged MH - *SARS-CoV-2 MH - Young Adult PMC - PMC7674115 OTO - NOTNLM OT - Air travel OT - COVID-19 OT - Communicable diseases OT - Infection control OT - Travel-related illness EDAT- 2020/12/12 06:00 MHDA- 2021/05/06 06:00 PMCR- 2020/11/19 CRDT- 2020/12/11 05:45 PHST- 2020/10/22 00:00 [received] PHST- 2020/11/04 00:00 [revised] PHST- 2020/11/08 00:00 [accepted] PHST- 2020/12/12 06:00 [pubmed] PHST- 2021/05/06 06:00 [medline] PHST- 2020/12/11 05:45 [entrez] PHST- 2020/11/19 00:00 [pmc-release] AID - S2468-0451(20)30086-9 [pii] AID - 10.1016/j.idh.2020.11.002 [doi] PST - ppublish SO - Infect Dis Health. 2021 May;26(2):110-117. doi: 10.1016/j.idh.2020.11.002. Epub 2020 Nov 19. PMID- 19305501 OWN - NLM STAT- MEDLINE DCOM- 20090424 LR - 20211020 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 4 IP - 3 DP - 2009 TI - Psychological typhoon eye in the 2008 Wenchuan earthquake. PG - e4964 LID - 10.1371/journal.pone.0004964 [doi] LID - e4964 AB - BACKGROUND: On May 12, 2008, an earthquake measuring 8.0 on the Richter scale jolted Wenchuan, China, leading to 69,227 deaths and 374,643 injured, with 17,923 listed as missing as of Sept. 25, 2008, and shook the whole nation. We assessed the devastating effects on people's post-earthquake concern about safety and health. METHODOLOGY/PRINCIPAL FINDINGS: From June 4 to July 15, 2008, we surveyed a convenience sample of 2,262 adults on their post-earthquake concern about safety and health. Residents in non-devastated areas (Fujian and Hunan Provinces, and Beijing) and devastated areas (Sichuan and Gansu Provinces) responded to a questionnaire of 5 questions regarding safety measures, epidemic disease, medical workers, psychological workers, and medication. The ANOVAs showed a significant effect of residential devastation level on the estimated number of safety measures needed, the estimated probability of the outbreak of an epidemic, and the estimated number of medical and psychological workers needed (Ps<0.001). The post-earthquake concern decreased significantly as the level of residential devastation increased. Because of the similarity with the meteorological phenomenon of the eye of a typhoon, we dubbed these findings a "Psychological Typhoon Eye": the closer to the center of the devastated areas, the less the concern about safety and health a resident felt. CONCLUSIONS/SIGNIFICANCE: Contrary to common perception and ripple effect that the impact of an unfortunate event decays gradually as ripples spread outward from a center, a "Psychological Typhoon Eye" effect was observed where the post-earthquake concern was at its lowest level in the extremely devastated areas. The resultant findings may have implications for Chinese governmental strategies for putting "psychological comfort" into effect. FAU - Li, Shu AU - Li S AD - Institute of Psychology, Chinese Academy of Sciences, Beijing, China. FAU - Rao, Li-Lin AU - Rao LL FAU - Ren, Xiao-Peng AU - Ren XP FAU - Bai, Xin-Wen AU - Bai XW FAU - Zheng, Rui AU - Zheng R FAU - Li, Jin-Zhen AU - Li JZ FAU - Wang, Zuo-Jun AU - Wang ZJ FAU - Liu, Huan AU - Liu H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090323 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Child MH - China MH - *Data Collection MH - *Earthquakes MH - Emergency Medical Services MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Safety MH - Stress Disorders, Post-Traumatic MH - Stress, Psychological/*psychology MH - Surveys and Questionnaires MH - Young Adult PMC - PMC2654756 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2009/03/24 09:00 MHDA- 2009/04/25 09:00 PMCR- 2009/03/23 CRDT- 2009/03/24 09:00 PHST- 2008/10/24 00:00 [received] PHST- 2009/02/24 00:00 [accepted] PHST- 2009/03/24 09:00 [entrez] PHST- 2009/03/24 09:00 [pubmed] PHST- 2009/04/25 09:00 [medline] PHST- 2009/03/23 00:00 [pmc-release] AID - 08-PONE-RA-07006R1 [pii] AID - 10.1371/journal.pone.0004964 [doi] PST - ppublish SO - PLoS One. 2009;4(3):e4964. doi: 10.1371/journal.pone.0004964. Epub 2009 Mar 23. PMID- 38922648 OWN - NLM STAT- MEDLINE DCOM- 20240626 LR - 20241002 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 10 DP - 2024 Jun 26 TI - Effectiveness, Safety, and Acceptability of Primaquine Mass Drug Administration in Low-Endemicity Areas in Southern Thailand: Proof-of-Concept Study. PG - e51993 LID - 10.2196/51993 [doi] LID - e51993 AB - BACKGROUND: A challenge in achieving the malaria-elimination target in the Greater Mekong Subregion, including Thailand, is the predominance of Plasmodium vivax malaria, which has shown extreme resilience to control measures. OBJECTIVE: This proof-of-concept study aimed to provide evidence for implementing primaquine mass drug administration (pMDA) as a strategy for P. vivax elimination in low-endemicity settings. METHODS: The study employed a mixed-methods trial to thoroughly evaluate the effectiveness, safety, acceptability, and community engagement of pMDA. The quantitative part was designed as a 2-period cluster-crossover randomized controlled trial. The intervention was pMDA augmented to the national prevention and control standards with directly observed treatment (DOT) by village health volunteers. The qualitative part employed in-depth interviews and brainstorming discussions. The study involved 7 clusters in 2 districts of 2 southern provinces in Thailand with persistently low P. vivax transmission. In the quantitative part, 5 cross-sectional blood surveys were conducted in both the pMDA and control groups before and 3 months after pMDA. The effectiveness of pMDA was determined by comparing the proportions of P. vivax infections per 1000 population between the 2 groups, with a multilevel zero-inflated negative binomial model adjusted for cluster and time as covariates and the interaction. The safety data comprised adverse events after drug administration. Thematic content analysis was used to assess the acceptability and engagement of stakeholders. RESULTS: In the pre-pMDA period, the proportions of P. vivax infections in the pMDA (n=1536) and control (n=1577) groups were 13.0 (95% CI 8.2-20.4) and 12.0 (95% CI 7.5-19.1), respectively. At month 3 post-pMDA, these proportions in the pMDA (n=1430) and control (n=1420) groups were 8.4 (95% CI 4.6-15.1) and 5.6 (95% CI 2.6-11.5), respectively. No statistically significant differences were found between the groups. The number of malaria cases reduced in all clusters in both groups, and thus, the impact of pMDA was inconclusive. There were no major safety concerns. Acceptance among the study participants and public health care providers at local and national levels was high, and they believed that pMDA had boosted awareness in the community. CONCLUSIONS: pMDA was associated with high adherence, safety, and tolerability, but it may not significantly impact P. vivax transmission. As this was a proof-of-concept study, we decided not to scale up the intervention with larger clusters and samples. An alternative approach involving a targeted primaquine treatment strategy with primaquine and DOT is currently being implemented. We experienced success regarding effective health care workforces at point-of-care centers, effective collaborations in the community, and commitment from authorities at local and national levels. Our efforts boosted the acceptability of the malaria-elimination initiative. Community engagement is recommended to achieve elimination targets. TRIAL REGISTRATION: Thai Clinical Trials Registry TCTR20190806004; https://www.thaiclinicaltrials.org/show/TCTR20190806004. CI - ©Jaranit Kaewkungwal, Wanlapa Roobsoong, Saranath Lawpoolsri, Wang Nguitragool, Suwich Thammapalo, Pathomporn Prikchoo, Amnat Khamsiriwatchara, Rungrawee Pawarana, Pawinee Jarujareet, Daniel M Parker, Piyarat Sripoorote, Mondha Kengganpanich, Chetta Ngamjarus, Jetsumon Sattabongkot, Liwang Cui. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 26.06.2024. FAU - Kaewkungwal, Jaranit AU - Kaewkungwal J AUID- ORCID: 0000-0001-7916-8460 AD - Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand. FAU - Roobsoong, Wanlapa AU - Roobsoong W AUID- ORCID: 0000-0002-1789-0439 AD - Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Lawpoolsri, Saranath AU - Lawpoolsri S AUID- ORCID: 0000-0003-4841-7924 AD - Department of Tropical Hygiene, Mahidol University, Bangkok, Thailand. FAU - Nguitragool, Wang AU - Nguitragool W AUID- ORCID: 0000-0002-5484-7130 AD - Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Thammapalo, Suwich AU - Thammapalo S AUID- ORCID: 0009-0007-2858-4748 AD - Ministry of Public Health, Nonthaburi, Thailand. FAU - Prikchoo, Pathomporn AU - Prikchoo P AUID- ORCID: 0009-0007-7171-6910 AD - Ministry of Public Health, Nonthaburi, Thailand. FAU - Khamsiriwatchara, Amnat AU - Khamsiriwatchara A AUID- ORCID: 0000-0001-9715-6658 AD - Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Pawarana, Rungrawee AU - Pawarana R AUID- ORCID: 0000-0003-4401-8803 AD - Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Jarujareet, Pawinee AU - Jarujareet P AUID- ORCID: 0009-0004-2972-0076 AD - Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Parker, Daniel M AU - Parker DM AUID- ORCID: 0000-0002-5352-7338 AD - Department of Population Health and Disease Prevention, University of California, Irvine, Irvine, CA, United States. AD - Department of Epidemiology and Biostatistics, University of California, Irvine, Irvine, CA, United States. FAU - Sripoorote, Piyarat AU - Sripoorote P AUID- ORCID: 0009-0004-1590-6654 AD - Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Kengganpanich, Mondha AU - Kengganpanich M AUID- ORCID: 0009-0008-7125-0193 AD - Department of Health Education and Behavioral Sciences, Faculty of Public Health, Mahidol University, Bangkok, Thailand. FAU - Ngamjarus, Chetta AU - Ngamjarus C AUID- ORCID: 0000-0002-5737-5941 AD - Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand. FAU - Sattabongkot, Jetsumon AU - Sattabongkot J AUID- ORCID: 0000-0002-3938-4588 AD - Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. FAU - Cui, Liwang AU - Cui L AUID- ORCID: 0000-0002-8338-1974 AD - Division of Infectious Diseases and Internal Medicine, Department of Internal Medicine, University of South Florida, Tampa, FL, United States. LA - eng GR - U19 AI089672/AI/NIAID NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20240626 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 RN - MVR3634GX1 (Primaquine) RN - 0 (Antimalarials) SB - IM MH - Humans MH - *Primaquine/therapeutic use/administration & dosage MH - Thailand/epidemiology MH - *Mass Drug Administration/methods/statistics & numerical data MH - Male MH - Female MH - Adult MH - Adolescent MH - *Malaria, Vivax/drug therapy MH - *Antimalarials/therapeutic use/administration & dosage MH - Middle Aged MH - Young Adult MH - Proof of Concept Study MH - Child MH - Cross-Over Studies MH - Cross-Sectional Studies MH - Patient Acceptance of Health Care/statistics & numerical data/psychology PMC - PMC11237773 OTO - NOTNLM OT - Plasmodium vivax OT - cluster-crossover randomized controlled trial OT - community-based trial OT - mass drug administration OT - participatory epidemiology OT - primaquine COIS- Conflicts of Interest: None declared. EDAT- 2024/06/26 12:43 MHDA- 2024/06/26 18:42 PMCR- 2024/06/26 CRDT- 2024/06/26 11:53 PHST- 2023/08/19 00:00 [received] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/01/28 00:00 [revised] PHST- 2024/06/26 18:42 [medline] PHST- 2024/06/26 12:43 [pubmed] PHST- 2024/06/26 11:53 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - v10i1e51993 [pii] AID - 10.2196/51993 [doi] PST - epublish SO - JMIR Public Health Surveill. 2024 Jun 26;10:e51993. doi: 10.2196/51993. PMID- 39060985 OWN - NLM STAT- MEDLINE DCOM- 20240727 LR - 20240729 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 24 IP - 1 DP - 2024 Jul 26 TI - Understanding willingness and barriers to participate in clinical trials during pregnancy and lactation: findings from a US study. PG - 504 LID - 10.1186/s12884-024-06710-w [doi] LID - 504 AB - BACKGROUND: Due to the exclusion of pregnant and lactating people from most clinical trials, there is an incomplete understanding of the risks and benefits of medication use in these populations and therapeutic decision-making is often conducted without adequate evidence. To change this paradigm, it is imperative to understand the perspectives of pregnant and lactating individuals concerning their participation in clinical trials. OBJECTIVES: To describe attitudes, perceptions, barriers, and preferences of pregnant and postpartum people in the United States (US) regarding participation in clinical trials and to identify factors influencing participation. METHODS: In November 2022, individuals aged ≥ 18 residing in the US who self-identified as pregnant or pregnant within the last 12 months were invited to complete an online survey about their perspectives regarding clinical trial participation. The survey included questions about demographic characteristics, health history, behaviors, and willingness to participate in clinical trials while pregnant and/or lactating. Multivariable logistic regression models were fit to identify predictors of clinical trial participation. RESULTS: Among the 654 respondents, 34.8% and 40.9% reported being likely or extremely likely to participate in a clinical trial for a new medication while pregnant or lactating, respectively; and 24.5% and 41.7% for a new vaccine while pregnant or lactating, respectively. Higher educational attainment (≥ Bachelor's degree) was associated with greater likelihood of clinical trial participation in pregnancy (odds ratio (OR) = 1.50, 95% Confidence Interval (CI): 1.01, 2.25 for medications; OR = 2.00, 95% CI: 1.28, 3.12 for vaccines). Chronic medical conditions were associated with a greater likelihood of participation in clinical trials for vaccines during lactation (OR = 1.59, 95% CI: 1.07, 2.36). The most cited motivator for participation in a clinical trial while pregnant or lactating was anticipated personal medical benefit (85.8% and 75.6%, respectively), while the primary deterrent was possible risk to the fetus or baby (97.9% and 97.2%, respectively). CONCLUSIONS: Willingness of a US sample to participate in clinical trials while pregnant or lactating varied by demographics and health status, with safety to the fetus being a nearly universal concern. These findings have implications for enhancing inclusion of pregnant and lactating people in clinical research and developing effective and equitable recruitment strategies. CI - © 2024. The Author(s). FAU - Jacobson, Melanie H AU - Jacobson MH AD - Global Epidemiology Organization, Janssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, US. Mjacob17@its.jnj.com. FAU - Yost, Emily AU - Yost E AD - Global Epidemiology Organization, Janssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, US. FAU - Sylvester, Shirley V AU - Sylvester SV AD - Global Public Health, Johnson & Johnson, Zug, Switzerland. FAU - Renz, Cheryl AU - Renz C AD - Pregistry, LLC, Los Angeles, CA, US. FAU - Wyszynski, Diego F AU - Wyszynski DF AD - Pregistry, LLC, London, England. FAU - Davis, Kourtney J AU - Davis KJ AD - Global Epidemiology Organization, Janssen Research & Development, LLC, 1125 Trenton-Harbourton Road, Titusville, NJ, 08560, US. LA - eng PT - Journal Article DEP - 20240726 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Lactation/psychology MH - Adult MH - United States MH - *Clinical Trials as Topic MH - Surveys and Questionnaires MH - Health Knowledge, Attitudes, Practice MH - Young Adult MH - Patient Participation/psychology MH - Patient Selection MH - Adolescent PMC - PMC11282851 OTO - NOTNLM OT - Clinical trial participation OT - Lactation OT - Pregnancy COIS- MHJ, EY, SVS, and KJD are employees of and hold stock in Johnson & Johnson. CR and DFW declare no conflict of interest. EDAT- 2024/07/27 10:42 MHDA- 2024/07/28 14:54 PMCR- 2024/07/26 CRDT- 2024/07/26 23:47 PHST- 2023/11/30 00:00 [received] PHST- 2024/07/19 00:00 [accepted] PHST- 2024/07/28 14:54 [medline] PHST- 2024/07/27 10:42 [pubmed] PHST- 2024/07/26 23:47 [entrez] PHST- 2024/07/26 00:00 [pmc-release] AID - 10.1186/s12884-024-06710-w [pii] AID - 6710 [pii] AID - 10.1186/s12884-024-06710-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2024 Jul 26;24(1):504. doi: 10.1186/s12884-024-06710-w. PMID- 39655627 OWN - NLM STAT- MEDLINE DCOM- 20250112 LR - 20250114 IS - 1326-5377 (Electronic) IS - 0025-729X (Print) IS - 0025-729X (Linking) VI - 222 IP - 1 DP - 2025 Jan 13 TI - Knowledge about COVID-19 vaccines among Aboriginal and Torres Strait Islander people, and attitudes to and behaviours regarding COVID-19 and influenza vaccination: a survey. PG - 30-37 LID - 10.5694/mja2.52551 [doi] AB - OBJECTIVES: To assess Aboriginal and Torres Strait Islander people's knowledge about coronavirus disease 2019 (COVID-19) vaccines, and their attitudes to and behaviours regarding COVID-19 and influenza vaccinations. STUDY DESIGN: Web-based survey. SETTING: Australia (excluding the Northern Territory), 1 October 2021 to 31 May 2022. PARTICIPANTS: Convenience sample of Aboriginal and Torres Strait Islander people aged 16 years or older living in Australia. MAIN OUTCOME MEASURES: Proportions of respondents who reported knowledge about COVID-19 vaccines, and attitudes to and behaviours regarding COVID-19 and influenza vaccinations. RESULTS: A total of 530 people provided valid survey responses; their median age was 27 years (interquartile range, 23-38 years), 255 (48%) were from urban areas, and 309 (58%) were men. Of the 480 participants (91%) who provided complete survey questions (including sex and location information), larger proportion of men than women believed COVID-19 vaccines were very or extremely trustworthy (219, 79% v 124, 61%) and very or extremely effective (212, 76% v 138, 68%). The prevalence of COVID-19 vaccination was lower among respondents aged 60 years or older than among those aged 16-29 years (adjusted prevalence ration [PR], 0.81; 95% confidence interval [CI], 0.66-0.99). After adjusting for socio-demographic factors, the association between intention to receive the influenza vaccine and receiving the COVID-19 vaccine was statistically significant (adjusted PR, 1.18; 95% CI, 1.09-1.27). CONCLUSION: The high levels of trust in COVID-19 vaccines and their effectiveness indicate that Aboriginal and Torres Strait Islander people are confident about their safety and efficacy and understand the importance of vaccination. The findings also highlight a positive attitude to vaccination and a commitment to preventive health measures among Aboriginal and Torres Strait Islander people. CI - © 2024 The Author(s). Medical Journal of Australia published by John Wiley & Sons Australia, Ltd on behalf of AMPCo Pty Ltd. FAU - Spierings, Shea AU - Spierings S AUID- ORCID: 0000-0002-2691-6848 AD - Poche Centre for Indigenous Health, University of Queensland, Brisbane, QLD. AD - ARC Centre of Excellence for Indigenous Futures, the University of Queensland, Brisbane, QLD. FAU - Oguoma, Victor M AU - Oguoma VM AUID- ORCID: 0000-0001-9505-7197 AD - Poche Centre for Indigenous Health, University of Queensland, Brisbane, QLD. FAU - Shakeshaft, Anthony AU - Shakeshaft A AD - Poche Centre for Indigenous Health, University of Queensland, Brisbane, QLD. FAU - Walker, Jim AU - Walker J AD - The University of Queensland, Brisbane, QLD. FAU - Toombs, Maree AU - Toombs M AD - The University of Sydney, Sydney, NSW. FAU - Ward, James S AU - Ward JS AD - ARC Centre of Excellence for Indigenous Futures, the University of Queensland, Brisbane, QLD. LA - eng GR - Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20241210 PL - Australia TA - Med J Aust JT - The Medical journal of Australia JID - 0400714 RN - 0 (COVID-19 Vaccines) RN - 0 (Influenza Vaccines) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Australia/epidemiology MH - Australian Aboriginal and Torres Strait Islander Peoples MH - *COVID-19/prevention & control/epidemiology/ethnology MH - *COVID-19 Vaccines/administration & dosage MH - *Health Knowledge, Attitudes, Practice/ethnology MH - *Influenza Vaccines/administration & dosage MH - Influenza, Human/prevention & control/ethnology MH - Surveys and Questionnaires MH - Vaccination/statistics & numerical data/psychology PMC - PMC11725265 OTO - NOTNLM OT - COVID‐19 OT - Indigenous health OT - Influenza OT - Vaccination COIS- No relevant disclosures. EDAT- 2024/12/10 12:27 MHDA- 2025/01/12 15:23 PMCR- 2025/01/12 CRDT- 2024/12/10 06:23 PHST- 2024/01/16 00:00 [received] PHST- 2024/05/07 00:00 [accepted] PHST- 2025/01/12 15:23 [medline] PHST- 2024/12/10 12:27 [pubmed] PHST- 2024/12/10 06:23 [entrez] PHST- 2025/01/12 00:00 [pmc-release] AID - MJA252551 [pii] AID - 10.5694/mja2.52551 [doi] PST - ppublish SO - Med J Aust. 2025 Jan 13;222(1):30-37. doi: 10.5694/mja2.52551. Epub 2024 Dec 10. PMID- 33322332 OWN - NLM STAT- MEDLINE DCOM- 20201222 LR - 20201229 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 17 IP - 24 DP - 2020 Dec 11 TI - Parental Hesitancy and Concerns around Accessing Paediatric Unscheduled Healthcare during COVID-19: A Cross-Sectional Survey. LID - 10.3390/ijerph17249264 [doi] LID - 9264 AB - A decrease in attendance at emergency departments among paediatric populations has been reported during the Coronavirus Disease 2019 (COVID-19) pandemic. The present study sought to understand parents' hesitancy and concerns around accessing healthcare during the pandemic using a cross-sectional survey of parents of children under the age of 16 (N = 1044) in Ireland. Multinomial and logistic regression analyses were used to determine the factors that influenced avoidance and hesitancy. In total, 34% of participants stated that their child required healthcare during the pandemic, of whom 22% decided against seeking healthcare. Parents who reported being much more hesitant about accessing healthcare were more likely to report mild-moderate (Relative Risk Ratio (RRR) = 2.31, CI: 1.54-3.47) and severe-extremely severe stress (RRR: 3.37, CI: 1.81-6.27). Parents who understood government advice to mean avoiding health services were more likely to be hesitant to attend (RRR: 1.71, CI; 1.10-2.67). These effects held when restrictions were beginning to be lifted. Higher levels of stress were associated with a parent believing that the government advice meant that they should not attend health services (OR: 1.66, CI: 1.14-2.41). Public health messaging must ensure parents are reassured on the accessibility and safety of paediatric healthcare services as this public health emergency continues. FAU - Nicholson, Emma AU - Nicholson E AUID- ORCID: 0000-0002-6652-2552 AD - UCD Centre for Interdisciplinary Research Education and Innovation in Health Systems, UCD School of Nursing, Midwifery & Health Systems, University College Dublin, D04 V1W8 Dublin, Ireland. FAU - McDonnell, Thérèse AU - McDonnell T AUID- ORCID: 0000-0002-5890-3689 AD - UCD Centre for Interdisciplinary Research Education and Innovation in Health Systems, UCD School of Nursing, Midwifery & Health Systems, University College Dublin, D04 V1W8 Dublin, Ireland. FAU - Conlon, Ciara AU - Conlon C AD - UCD Centre for Interdisciplinary Research Education and Innovation in Health Systems, UCD School of Nursing, Midwifery & Health Systems, University College Dublin, D04 V1W8 Dublin, Ireland. FAU - Barrett, Michael AU - Barrett M AUID- ORCID: 0000-0003-1775-8347 AD - Children's Health Ireland at Crumlin, D12 N512 Dublin, Ireland. AD - Women's and Children's Health, School of Medicine, University College Dublin, D04 V1W8 Dublin, Ireland. AD - National Children's Research Centre, D12 N512 Dublin, Ireland. FAU - Cummins, Fergal AU - Cummins F AD - REDSPOT, Emergency Department, Limerick University Hospital, V94 F858 Limerick, Ireland. FAU - Hensey, Conor AU - Hensey C AD - Children's Health Ireland at Temple Street, D01 XD99 Dublin, Ireland. FAU - McAuliffe, Eilish AU - McAuliffe E AUID- ORCID: 0000-0002-9714-5040 AD - UCD Centre for Interdisciplinary Research Education and Innovation in Health Systems, UCD School of Nursing, Midwifery & Health Systems, University College Dublin, D04 V1W8 Dublin, Ireland. LA - eng GR - COV19-2020-076/Health Research Board/Ireland PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201211 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Adult MH - Anxiety MH - *COVID-19 MH - Child MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Humans MH - Ireland MH - Male MH - Middle Aged MH - *Pandemics MH - Parents/*psychology MH - Patient Acceptance of Health Care/*psychology MH - *Pediatrics MH - Risk Assessment PMC - PMC7763208 OTO - NOTNLM OT - COVID-19 OT - avoidance OT - cross-sectional survey OT - hesitancy OT - paediatric healthcare OT - parents COIS- The authors declare no conflict of interest. EDAT- 2020/12/17 06:00 MHDA- 2020/12/23 06:00 PMCR- 2020/12/01 CRDT- 2020/12/16 01:03 PHST- 2020/10/30 00:00 [received] PHST- 2020/12/08 00:00 [revised] PHST- 2020/12/09 00:00 [accepted] PHST- 2020/12/16 01:03 [entrez] PHST- 2020/12/17 06:00 [pubmed] PHST- 2020/12/23 06:00 [medline] PHST- 2020/12/01 00:00 [pmc-release] AID - ijerph17249264 [pii] AID - ijerph-17-09264 [pii] AID - 10.3390/ijerph17249264 [doi] PST - epublish SO - Int J Environ Res Public Health. 2020 Dec 11;17(24):9264. doi: 10.3390/ijerph17249264. PMID- 22425060 OWN - NLM STAT- MEDLINE DCOM- 20121113 LR - 20181201 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 22 IP - 7 DP - 2012 Jul TI - Modafinil for excessive daytime sleepiness in myotonic dystrophy type 1--the patients' perspective. PG - 597-603 LID - 10.1016/j.nmd.2012.02.005 [doi] AB - Excessive daytime sleepiness (EDS), of very similar pattern to that seen in narcolepsy syndrome, is extremely common in myotonic dystrophy type 1 (DM1). In a significant minority it has a profound disabling effect on employment, social functioning and activities of daily living. Limited published studies have shown inconsistent results from use of the psychostimulant drug modafinil. A recent European Medicines Agency (EMA) review concluded that on current evidence regarding safety and efficacy, modafinil's use should be restricted to the treatment of narcolepsy. In other conditions (although DM1 was not specifically considered) it was concluded that there was insufficient evidence of benefit to outweigh potentially serious side-effects, including severe skin reactions and cardiac arrhythmia. Clinicians with extensive experience in the management of DM1 have found modafinil to be extremely effective in appropriately selected patients with a very low incidence of serious side-effects. Given the recent EMA review, patients have expressed concern about the potential restriction of the use of modafinil in DM1. This brief review is an audit of the experience of a large group of patients and their clinicians concerning EDS and DM1 and concludes that despite the limited literature there is strong evidence to support the use of modafinil in carefully selected patients. CI - Copyright © 2012 Elsevier B.V. All rights reserved. FAU - Hilton-Jones, D AU - Hilton-Jones D AD - Department of Neurology, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK. david.hilton-jones@clneuro.ox.ac.uk FAU - Bowler, M AU - Bowler M FAU - Lochmueller, H AU - Lochmueller H FAU - Longman, C AU - Longman C FAU - Petty, R AU - Petty R FAU - Roberts, M AU - Roberts M FAU - Rogers, M AU - Rogers M FAU - Turner, C AU - Turner C FAU - Wilcox, D AU - Wilcox D LA - eng PT - Journal Article DEP - 20120316 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 RN - 0 (Benzhydryl Compounds) RN - 0 (Central Nervous System Stimulants) RN - R3UK8X3U3D (Modafinil) SB - IM MH - Benzhydryl Compounds/*therapeutic use MH - Central Nervous System Stimulants/*therapeutic use MH - *Disorders of Excessive Somnolence/drug therapy/etiology/psychology MH - Female MH - Humans MH - Male MH - Modafinil MH - Myotonic Dystrophy/*complications/epidemiology MH - Surveys and Questionnaires MH - United Kingdom/epidemiology EDAT- 2012/03/20 06:00 MHDA- 2012/11/14 06:00 CRDT- 2012/03/20 06:00 PHST- 2011/12/30 00:00 [received] PHST- 2012/02/05 00:00 [revised] PHST- 2012/02/07 00:00 [accepted] PHST- 2012/03/20 06:00 [entrez] PHST- 2012/03/20 06:00 [pubmed] PHST- 2012/11/14 06:00 [medline] AID - S0960-8966(12)00054-5 [pii] AID - 10.1016/j.nmd.2012.02.005 [doi] PST - ppublish SO - Neuromuscul Disord. 2012 Jul;22(7):597-603. doi: 10.1016/j.nmd.2012.02.005. Epub 2012 Mar 16. PMID- 8893908 OWN - NLM STAT- MEDLINE DCOM- 19970312 LR - 20071114 IS - 0954-0121 (Print) IS - 0954-0121 (Linking) VI - 8 IP - 5 DP - 1996 Oct TI - Predicting dentists' willingness to treat HIV-infected patients. PG - 581-8 AB - Access to oral health care is extremely important for those infected with HIV, because oral findings can lead to early detection and improved staging and management of HIV infection. In addition, oral lesions associated with HIV infection are often debilitating, but can be managed effectively with proper oral health care. There is ample evidence that dentists have, at times, resisted accepting HIV positive patients (PHIV+). The intent of the research project described below was to develop and test a model predicting dentists' willingness to treat PHIV+. Data were collected from a sample of dentists practising in New York City. The dependent variable was a scale constructed of items measuring willingness to treat PHIV+ under varying conditions. Independent variables were entered into a multiple linear regression equation in iterative attempts to arrive at a model predicting dentists' willingness to treat PHIV+, which was both parsimonious and had explanatory power. The final model included five independent variables measuring: (1) perceived safety; (2) willingness to treat homosexuals; (3) perceived ethical obligation to treat PHIV +; (4) past experience; and (5) perceived norms of colleagues. Perceived safety and perceived norms of colleagues had by far the most predictive power of all independent variables. R2 for the model = 0.58. FAU - Sadowsky, D AU - Sadowsky D AD - Columbia University, School of Dental and Oral Surgery, New York, NY 10032, USA. FAU - Kunzel, C AU - Kunzel C LA - eng GR - DE 10301/DE/NIDCR NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - AIDS Care JT - AIDS care JID - 8915313 SB - IM MH - Attitude of Health Personnel MH - Dental Care for Chronically Ill/psychology/*statistics & numerical data MH - Dentists/*psychology/standards/statistics & numerical data MH - Ethics, Dental MH - HIV Infections/*psychology MH - Health Services Accessibility/*statistics & numerical data MH - Homosexuality MH - Humans MH - Linear Models MH - *Models, Psychological MH - Multivariate Analysis MH - New York City MH - Refusal to Treat/*statistics & numerical data MH - Safety MH - Sampling Studies MH - Social Perception OID - NRCBL: VF 9.5.6 OTO - KIE OT - Empirical Approach OT - Health Care and Public Health OT - Professional Patient Relationship GN - KIE: 40 refs. GN - KIE: KIE Bib: AIDS/health personnel EDAT- 1996/10/01 00:00 MHDA- 1996/10/01 00:01 CRDT- 1996/10/01 00:00 PHST- 1996/10/01 00:00 [pubmed] PHST- 1996/10/01 00:01 [medline] PHST- 1996/10/01 00:00 [entrez] AID - MFJY7AGNYUAFV2PW [pii] AID - 10.1080/09540129650125533 [doi] PST - ppublish SO - AIDS Care. 1996 Oct;8(5):581-8. doi: 10.1080/09540129650125533. PMID- 22607254 OWN - NLM STAT- MEDLINE DCOM- 20120827 LR - 20181201 IS - 1538-957X (Electronic) IS - 1538-9588 (Linking) VI - 13 IP - 3 DP - 2012 TI - Nonconformities in real-world fatal crashes--electronic stability control and seat belt reminders. PG - 308-14 LID - 10.1080/15389588.2011.653842 [doi] AB - OBJECTIVE: Many new safety systems are entering the market. Vision Zero is a safety strategy aiming at the elimination of fatalities and impairing injuries by the use of a holistic model for safe traffic to develop a safe system. The aim of this article is to analyze fatalities in modern cars with respect to the Vision Zero model with special respect to electronic stability control (ESC) systems and modern seat belt reminders (SBRs). The model is used to identify and understand cases where cars with ESC systems lost control and where occupants were unbelted in a seat with seat belt reminders under normal driving conditions. METHODS: The model for safe traffic was used to analyze in-depth studies of fatal crashes with respect to seat belt use and loss of control. Vehicles from 2003 and later in crashes from January 2004 to mid-2010 were analyzed. The data were analyzed case by case. Cars that were equipped with ESC systems and lost control and occupants not using the seat belt in a seat with a seat belt reminder were considered as nonconformities. A total of 138 fatal crashes involving 152 fatally injured occupants were analyzed. RESULTS: Cars with ESC systems had fewer loss-of-control-relevant cases than cars without ESC systems. Thirteen percent of the ESC-equipped vehicles had loss-of-control-relevant crashes and 36 percent of the cars without ESC systems had loss-of-control-relevant crashes. The analysis indicates that only one car of the 9 equipped with ESC that lost control did it on a road surface with relevant friction when driving within the speed restriction of the road. In seats with seat belt reminders that are in accordance with the European New Car Assessment Programme's (Euro NCAP) protocol, 93 percent of the occupants were using a seat belt. In seats without reminders this number was 74 percent. CONCLUSIONS: This study shows that ESC systems result in a very significant reduction in fatal crashes, especially under normal driving conditions. Under extreme driving conditions such as speeding or extremely low friction (snow or on the side of the road), ESC systems can fail in keeping the car under control. Seat belt reminders result in higher seat belt use rates but the level of unbelted occupants is higher than roadside studies have indicated. The holistic Vision Zero approach helped in the analysis by identifying nonconformities and putting these into the safe systems perspective. FAU - Lie, Anders AU - Lie A AD - Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. anders.lie@trafikverket.se LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Traffic Inj Prev JT - Traffic injury prevention JID - 101144385 SB - IM MH - Accidents, Traffic/*mortality/prevention & control MH - Automobile Driving/*psychology MH - Automobiles/*statistics & numerical data MH - Humans MH - Protective Devices/*statistics & numerical data MH - Reminder Systems/*statistics & numerical data MH - Safety Management/*methods MH - Seat Belts/statistics & numerical data MH - Sweden/epidemiology EDAT- 2012/05/23 06:00 MHDA- 2012/08/28 06:00 CRDT- 2012/05/22 06:00 PHST- 2012/05/22 06:00 [entrez] PHST- 2012/05/23 06:00 [pubmed] PHST- 2012/08/28 06:00 [medline] AID - 10.1080/15389588.2011.653842 [doi] PST - ppublish SO - Traffic Inj Prev. 2012;13(3):308-14. doi: 10.1080/15389588.2011.653842. PMID- 23434845 OWN - NLM STAT- MEDLINE DCOM- 20130827 LR - 20130307 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 53 DP - 2013 Apr TI - The effects of age and traffic density on street-crossing behavior. PG - 166-75 LID - S0001-4575(12)00450-2 [pii] LID - 10.1016/j.aap.2012.12.028 [doi] AB - Past research has shown that road users accept shorter time gaps when the waiting time/number of vehicles they let pass before attempting to merge into the traffic increases. While elderly pedestrians are known to be an extremely vulnerable group of road users, very few studies dealt with the effect of environmental constraints and crossing complexity on this population's safety. The present study aimed at determining whether or not street-crossing decisions and behavior of younger and older pedestrians were differently affected by a traffic flow. In an interactive street-crossing task, we assessed whether mean time gap and crossing decisions depended on the position of the gap pedestrians selected into the traffic stream. Results revealed that irrespective of their age pedestrians accepted a smaller time gap when they chose the second interval of the traffic compared to the first one. Contrasting with previous hypotheses, this traffic-related behavior was not accompanied by an increase in the decisions risk. The findings also showed that the transition threshold from rejecting to accepting time gaps was shorter when the second interval was selected compared to the first one. This increment in task constraints might help younger and older pedestrians alike to perceive action possibilities more accurately and to be better attuned to traffic conditions by comparing gaps between each other. This opens an interesting perspective in the understanding and the training of the ability of elderly road users to remain accurate in their judgements. CI - Copyright © 2013. Published by Elsevier Ltd. FAU - Lobjois, Régis AU - Lobjois R AD - Laboratory for Road Operations, Perception, Simulators and Simulations, French Institute of Science and Technology for Transport, Development and Networks, France. lobjois@ifsttar.fr FAU - Benguigui, Nicolas AU - Benguigui N FAU - Cavallo, Viola AU - Cavallo V LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130110 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/prevention & control/*psychology MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Analysis of Variance MH - *Choice Behavior MH - Computer Simulation MH - *Environment MH - Female MH - Humans MH - Locomotion MH - Male MH - Middle Aged MH - Risk-Taking MH - *Safety MH - Time Factors EDAT- 2013/02/26 06:00 MHDA- 2013/08/28 06:00 CRDT- 2013/02/26 06:00 PHST- 2011/06/29 00:00 [received] PHST- 2012/11/26 00:00 [revised] PHST- 2012/12/20 00:00 [accepted] PHST- 2013/02/26 06:00 [entrez] PHST- 2013/02/26 06:00 [pubmed] PHST- 2013/08/28 06:00 [medline] AID - S0001-4575(12)00450-2 [pii] AID - 10.1016/j.aap.2012.12.028 [doi] PST - ppublish SO - Accid Anal Prev. 2013 Apr;53:166-75. doi: 10.1016/j.aap.2012.12.028. Epub 2013 Jan 10. PMID- 29338989 OWN - NLM STAT- MEDLINE DCOM- 20180906 LR - 20180906 IS - 1545-1534 (Electronic) IS - 1080-6032 (Linking) VI - 29 IP - 1 DP - 2018 Mar TI - Relations Between Self-Reported and Linguistic Monitoring Assessments of Affective Experience in an Extreme Environment. PG - 61-65 LID - S1080-6032(17)30258-2 [pii] LID - 10.1016/j.wem.2017.08.023 [doi] AB - INTRODUCTION: Approaches for monitoring psychosocial health in challenging environments are needed to maintain the performance and safety of personnel. The purpose of the present research was to examine the relationship between 2 candidate methods (self-reported and linguistics) for monitoring affective experience during extreme environment activities. METHODS: A single-subject repeated-measures design was used in the present work. The participant was a 46-year-old individual scheduled to complete a self-supported ski expedition across Arctic Greenland. The expedition lasted 28 days, and conditions included severe cold, low stimulation, whiteouts, limited habitability, and threats to life and limb. During the expedition, the participant completed a daily self-report log including assessment of psychological health (perceptions of control and affect) and a video diary (emotion). Video diary entries were subjected to linguistic inquiry and word count analyses before the links between self-report and linguistic data across the expedition period were tested. RESULTS: Similarities in the pattern of self-reported and linguistic assessments emerged across the expedition period. A number of predictable correlations were identified between self-reported and linguistic assessments of affective/emotional experience. Overall, there was better agreement between self-reports and linguistic analytics for indicators of negative affect/emotion. CONCLUSIONS: Future research should build on this initial study to further test the links between self-reported affect and emotional states monitored via linguistics. This could help develop methods for monitoring psychological health in extreme environments and support organizational decision making. CI - Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved. FAU - Smith, Nathan AU - Smith N AD - University of Northampton, Northampton, United Kingdom. Electronic address: nathan.j.smithphd@gmail.com. LA - eng PT - Journal Article DEP - 20180112 PL - United States TA - Wilderness Environ Med JT - Wilderness & environmental medicine JID - 9505185 SB - IM MH - *Extreme Environments MH - Greenland MH - Humans MH - *Linguistics MH - Male MH - *Mental Health MH - Middle Aged MH - Psychometrics/*methods MH - *Self Report MH - Skiing/*psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - emotion OT - extreme environment OT - linguistic analysis OT - monitoring OT - self-reports EDAT- 2018/01/18 06:00 MHDA- 2018/09/07 06:00 CRDT- 2018/01/18 06:00 PHST- 2017/06/18 00:00 [received] PHST- 2017/08/17 00:00 [revised] PHST- 2017/08/31 00:00 [accepted] PHST- 2018/01/18 06:00 [pubmed] PHST- 2018/09/07 06:00 [medline] PHST- 2018/01/18 06:00 [entrez] AID - S1080-6032(17)30258-2 [pii] AID - 10.1016/j.wem.2017.08.023 [doi] PST - ppublish SO - Wilderness Environ Med. 2018 Mar;29(1):61-65. doi: 10.1016/j.wem.2017.08.023. Epub 2018 Jan 12. PMID- 29739433 OWN - NLM STAT- MEDLINE DCOM- 20190110 LR - 20231112 IS - 1744-8603 (Electronic) IS - 1744-8603 (Linking) VI - 14 IP - 1 DP - 2018 May 9 TI - "Because if we talk about health issues first, it is easier to talk about human trafficking"; findings from a mixed methods study on health needs and service provision among migrant and trafficked fishermen in the Mekong. PG - 45 LID - 10.1186/s12992-018-0361-x [doi] LID - 45 AB - BACKGROUND: Human trafficking in the fishing industry or "sea slavery" in the Greater Mekong Subregion is reported to involve some of the most extreme forms of exploitation and abuse. A largely unregulated sector, commercial fishing boats operate in international waters far from shore and outside of national jurisdiction, where workers are commonly subjected to life-threatening risks. Yet, research on the health needs of trafficked fishermen is sparse. This paper describes abuses, occupational hazards, physical and mental health and post-trafficking well-being among a systematic consecutive sample of 275 trafficked fishermen using post-trafficking services in Thailand and Cambodia. These findings are complemented by qualitative interview data collected with 20 key informants working with fishermen or on issues related to their welfare in Thailand. RESULTS: Men and boys trafficked for fishing (aged 12-55) were mainly from Cambodia (n = 217) and Myanmar (n = 55). Common physical health problems included dizzy spells (30.2%), exhaustion (29.5%), headaches (28.4%) and memory problems (24.0%). Nearly one-third (29.1%) reported pain in three or more areas of their body and one-quarter (26.9%) reported being in "poor" health. Physical health symptoms were strongly associated with: severe violence; injuries; engagement in long-haul fishing; immigration detention or symptoms of mental health disorders. Survivors were exposed to multiple work hazards and were perceived as disposable when disabled by illness or injuries. Employers struggled to apply internationally recommended Personal Protective Equipment (PPE) practices in Thailand. Non-governmental organizations (NGOs) encountered challenges when trying to obtain healthcare for uninsured fishermen. Challenges included fee payment, service provision in native languages and officials siding with employers in disputes over treatment costs and accident compensation. Survivors' post-trafficking concerns included: money problems (75.9%); guilt and shame (33.5%); physical health (33.5%) and mental health (15.3%). CONCLUSION: Fishermen in this region are exposed to very serious risks to their health and safety, and their illnesses and injuries often go untreated. Men who enter the fishing industry in Thailand, especially migrant workers, require safe working conditions and targeted protections from human trafficking. Survivors of the crime of sea slavery must be provided with the compensation they deserve and the care they need, especially psychological support. FAU - Pocock, Nicola S AU - Pocock NS AD - United Nations University International Institute of Global Health, UKM Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. nicola.pocock@unu.edu. FAU - Tadee, Reena AU - Tadee R AD - Institute for Population and Social Research, Mahidol University, Salaya, Phutthamonthon District, Nakhon Pathom, 73170, Thailand. FAU - Tharawan, Kanokwan AU - Tharawan K AD - Institute for Population and Social Research, Mahidol University, Salaya, Phutthamonthon District, Nakhon Pathom, 73170, Thailand. FAU - Rongrongmuang, Wansiri AU - Rongrongmuang W AD - Independent consultant, Bangkok, Thailand. FAU - Dickson, Brett AU - Dickson B AD - International Organization for Migration, Norodom Blvd, No. 281, 4th Floor, Sangkat Tonle Basac, Khan Chamkamorn, Phnom Penh, Cambodia. FAU - Suos, Soksreymom AU - Suos S AD - Independent consultant, Phnom Penh, Cambodia. FAU - Kiss, Ligia AU - Kiss L AD - Department of Global Health & Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, Kings Cross, London, WC1H 9SH, UK. FAU - Zimmerman, Cathy AU - Zimmerman C AD - Department of Global Health & Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, Kings Cross, London, WC1H 9SH, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180509 PL - England TA - Global Health JT - Globalization and health JID - 101245734 SB - IM MH - Adolescent MH - Adult MH - Cambodia/ethnology MH - Child MH - *Fisheries MH - *Human Trafficking MH - Humans MH - Male MH - Middle Aged MH - Myanmar/ethnology MH - *Needs Assessment MH - Qualitative Research MH - Survivors/*psychology/statistics & numerical data MH - Thailand MH - Transients and Migrants/*psychology/statistics & numerical data MH - Young Adult PMC - PMC5941587 OTO - NOTNLM OT - Cambodia OT - Fishing OT - Forced labour OT - Human trafficking OT - Migrant fishermen OT - Migrant health OT - Myanmar OT - Thailand OT - Trafficked fishermen COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: As noted in the Methods section, for quantitative data, written informed consent with trafficked fishermen using post-trafficking services in Thailand and Cambodia was obtained prior to interview. A strict ethics protocol based on the World Health Organization Ethical Recommendations for Interviewing Trafficked Women was followed [44]. Ethics approval was obtained from Institutional Review Boards at the Ministry of Social Development and Human Security in Thailand, the National Ethics Committee for Health Research in Cambodia and the London School of Hygiene and Tropical Medicine (LSHTM). The LSHTM IRB number is 5770. As noted in Methods, the port research site is not named to preserve the anonymity of participants interviewed for the qualitative component. Because of the small number of organizations and individuals working with migrant and trafficked fishermen, participants may be identifiable if the port research site is named. Written informed consent was obtained from each participant. Ethical approval was obtained from the LSHTM’s Observational Ethics Committee (IRB no. 8368) and from the Institute of Population and Social Research’s Institutional Review Board at Mahidol University (IRB No. 2014/1–1-22). COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2018/05/10 06:00 MHDA- 2019/01/11 06:00 PMCR- 2018/05/09 CRDT- 2018/05/10 06:00 PHST- 2017/09/14 00:00 [received] PHST- 2018/04/19 00:00 [accepted] PHST- 2018/05/10 06:00 [entrez] PHST- 2018/05/10 06:00 [pubmed] PHST- 2019/01/11 06:00 [medline] PHST- 2018/05/09 00:00 [pmc-release] AID - 10.1186/s12992-018-0361-x [pii] AID - 361 [pii] AID - 10.1186/s12992-018-0361-x [doi] PST - epublish SO - Global Health. 2018 May 9;14(1):45. doi: 10.1186/s12992-018-0361-x. PMID- 39416946 OWN - NLM STAT- MEDLINE DCOM- 20241017 LR - 20241018 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Exploring organizational aspects that promote health-related preventive behavior: using the example of work-related SARS-CoV-2 infection control measures in Germany, August 2020 to November 2021. PG - 1388996 LID - 10.3389/fpubh.2024.1388996 [doi] LID - 1388996 AB - INTRODUCTION: During the communicable coronavirus disease (COVID-19) pandemic, organizational infection control measures (oICMs) were introduced in the workplace. The employees' positive attitudes and active participation are relevant for full effectiveness regarding disease prevention. Therefore, we explore changes in employees' attitudes toward oICM at work from August-October 2020 (T0) over January 2021 (T1) to October-November 2021 (T2). We further investigate the role an organization can play in supporting health-related preventive behavior. METHODS: We considered repeated cross-sectional and longitudinal panel survey data from 5,554 employees of a global supplier of technology and services in Germany. A total of 16 items constitute the attitude scores toward oICM (5-point Likert scale). Via mixed-effect model, aspects associated with employees' attitudes toward oICM were explored. Via 'extreme-group' approach, we compared the 20% of participants with the largest changes into less favorable to the 20% with the largest changes into more favorable attitudes toward oICM over time. RESULTS: The overall positive attitudes toward work-related oICM were more favorable at T1 (mean ± SD: 4.2 ± 0.6, median (IQR): 4.3 (0.8), n = 2,515) compared to T0 (4.1 ± 0.6, 4.1 (0.8), n = 2,417) but less favorable at T2 (3.9 ± 0.7, 4.0 (0.9), n = 2,062). Among others, feeling well-informed about possible work-related risks of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), perceived psychosocial demands through work environment aspects, and perceived management's commitment to safety and health were associated with long-term positive attitudes toward oICM. Individuals developing more favorable attitudes toward oICM reported feeling well-informed about possible work-related SARS-CoV-2 infection risks and improved COVID-19-specific resilience over time. Individuals developing less favorable attitudes toward oICM reported decreased perceptions of COVID-19-associated risks. CONCLUSION: oICMs in the workplace were perceived appropriate even after COVID-19 vaccines were widely available although the perceived affective risks about SARS-CoV-2 decreased. Taken together, our findings highlight how organizations can support employees in adopting health-related preventive behavior. Among others, we found that feeling well-informed about possible work-related health risks was positively associated with long-term favorable attitudes toward work-related oICM. We expect that the results contribute to the development of interventions to prepare and adapt to future global public health concerns. CI - Copyright © 2024 Soeder, Wagner, Neunhöffer, Martus, Papenfuss, Wittich, Schwille-Kiuntke, Rind and Rieger. FAU - Soeder, Jana AU - Soeder J AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Wagner, Anke AU - Wagner A AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Neunhöffer, Anna T AU - Neunhöffer AT AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Martus, Peter AU - Martus P AD - Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany. FAU - Papenfuss, Falko AU - Papenfuss F AD - Medical Services, Robert Bosch GmbH, Stuttgart, Germany. FAU - Wittich, Andrea AU - Wittich A AD - Occupational Psychologist and Psychotherapist, Tübingen, Germany. FAU - Schwille-Kiuntke, Juliane AU - Schwille-Kiuntke J AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Rind, Esther AU - Rind E AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Rieger, Monika A AU - Rieger MA AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. LA - eng PT - Journal Article DEP - 20241002 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *COVID-19/prevention & control MH - Germany MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Workplace/psychology MH - Longitudinal Studies MH - Middle Aged MH - *SARS-CoV-2 MH - *Infection Control MH - Surveys and Questionnaires MH - Health Behavior PMC - PMC11480029 OTO - NOTNLM OT - COVID-19 OT - SARS-CoV-2 OT - attitude OT - health promotion OT - occupational safety and health OT - safety culture OT - working condition OT - workplace COIS- JS-K’s sole permanent employment relationship is with the Regierungspräsidium Tübingen/public health department Hechingen, Zollernalbkreis. She declares no conflict of interest. FP has been involved as consultant, expert, and co-author and is employed at the Robert Bosch GmbH. FP has been primarily involved in developing the study idea and the design and content of the online employee survey. The participating company had no role in the analysis of data, the interpretation of results, or the decision to publish the results. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/17 10:44 MHDA- 2024/10/17 10:45 PMCR- 2024/10/02 CRDT- 2024/10/17 05:01 PHST- 2024/02/20 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/10/17 10:45 [medline] PHST- 2024/10/17 10:44 [pubmed] PHST- 2024/10/17 05:01 [entrez] PHST- 2024/10/02 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1388996 [doi] PST - epublish SO - Front Public Health. 2024 Oct 2;12:1388996. doi: 10.3389/fpubh.2024.1388996. eCollection 2024. PMID- 31177518 OWN - NLM STAT- MEDLINE DCOM- 20190617 LR - 20200630 IS - 1833-3516 (Print) IS - 2209-1491 (Electronic) IS - 1833-3516 (Linking) VI - 49 IP - 2 DP - 2019 Jun 30 TI - Early detection of diving-related cognitive impairment of different nitrogen-oxygen gas mixtures using critical flicker fusion frequency. PG - 119-126 LID - 10.28920/dhm49.2.119-126 [doi] AB - INTRODUCTION: Cognitive impairment related to inert gas narcosis (IGN) is a threat to diving safety and operations at depth that might be reduced by using enriched air nitrox (EANx) mixtures. Using critical flicker fusion frequency (CFFF), a possible early detection of cognitive abilities/cerebral arousal impairment when breathing different oxygen (O2) fractions was investigated. METHODS: Eight male volunteers performed, in random order, two dry chamber dives breathing either air or EANx40 (40% O₂-60% nitrogen) for 20 minutes (min) at 0.4 MPa. Cognition and arousal were assessed before the dive; upon arrival at 0.4 MPa; after 15 min exposure at 0.4 MPa; on surfacing and 30 min post-dive using behavioural computer-based testing psychology experiment building language (PEBL) and by CFFF while continuously recording brain oxygenation with near-infrared spectroscopy. RESULTS: In both breathing conditions, CFFF and PEBL demonstrated a significant inverse correlation (Pearson r of -0.90, P < 0.0001), improved cognitive abilities/cerebral arousal occurred upon arrival at 0.4 MPa followed by a progressive deterioration. Initial brain activation was associated with a significant increase in oxyhaemoglobin (HbO2) and a simultaneous decrease of deoxyhaemoglobin (HHb). The magnitude of the changes was significantly greater under EANx (P = 0.038). CONCLUSIONS: Since changes were not related to haemodynamic variables, HbO₂ and HHb values indicate a significant, O₂-dependent activation in the prefrontal cortex. Owing to the correlation with some tests from the PEBL, CFFF could be a convenient measure of cognitive performance/ability in extreme environments, likely under the direct influence of oxygen partial pressure, a potent modulator of IGN symptoms. CI - Copyright: This article is the copyright of the authors who grant Diving and Hyperbaric Medicine a non-exclusive licence to publish the article in electronic and other forms. FAU - Lafère, Pierre AU - Lafère P AD - DAN Europe Research Division, Roseto, Italy. AD - Laboratoire ORPHY, EA 4324, UFR sciences et techniques, Université de Bretagne Occidentale, Brest, France. AD - Environmental, Occupational, Ageing (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), Brussels, Belgium. AD - Corresponding author: Pierre Lafère, Laboratoire ORPHY, EA 4324, UFR sciences et techniques, Université de Bretagne Occidentale, 6 Avenue Le Gorgeu - CS 93837, 29238 Brest Cedex 3, France, doc.lafere@sfr.fr. FAU - Hemelryck, Walter AU - Hemelryck W AD - DAN Europe Research Division, Roseto, Italy. AD - Environmental, Occupational, Ageing (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), Brussels, Belgium. FAU - Germonpré, Peter AU - Germonpré P AD - DAN Europe Research Division, Roseto, Italy. AD - Centre for Hyperbaric Oxygen Therapy, Military Hospital 'Queen Astrid', Brussels. FAU - Matity, Lyubisa AU - Matity L AD - Hyperbaric Unit, Mater Dei Hospital, Msida, Malta. FAU - Guerrero, François AU - Guerrero F AD - DAN Europe Research Division, Roseto, Italy. AD - Laboratoire ORPHY, EA 4324, UFR sciences et techniques, Université de Bretagne Occidentale, Brest, France. FAU - Balestra, Costantino AU - Balestra C AD - DAN Europe Research Division, Roseto, Italy. AD - Environmental, Occupational, Ageing (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), Brussels, Belgium. AD - Anatomical Research and Clinical Studies (ARCS), Vrije Universiteit Brussel (V.U.B.), Brussels. AD - Anatomical Research Training and Education (ARTE), Vrije Universiteit Brussel (V.U.B.). AD - Motor Sciences, Université Libre De Bruxelles (U.L.B.), Brussels. LA - eng PT - Journal Article PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 RN - N762921K75 (Nitrogen) RN - S88TT14065 (Oxygen) SB - IM MH - *Cognitive Dysfunction/chemically induced MH - *Diving/adverse effects MH - Flicker Fusion MH - Humans MH - Nitrogen/administration & dosage/*adverse effects MH - Oxygen/administration & dosage/*adverse effects PMC - PMC6704008 OTO - NOTNLM OT - Enriched air – nitrox OT - Narcosis OT - Near-infrared spectroscopy OT - Oxygen OT - Risk management COIS- Conflict of interest: nil EDAT- 2019/06/10 06:00 MHDA- 2019/06/18 06:00 PMCR- 2020/06/30 CRDT- 2019/06/10 06:00 PHST- 2018/09/19 00:00 [received] PHST- 2019/03/08 00:00 [accepted] PHST- 2019/06/10 06:00 [entrez] PHST- 2019/06/10 06:00 [pubmed] PHST- 2019/06/18 06:00 [medline] PHST- 2020/06/30 00:00 [pmc-release] AID - 10.28920/dhm49.2.119-126 [doi] PST - ppublish SO - Diving Hyperb Med. 2019 Jun 30;49(2):119-126. doi: 10.28920/dhm49.2.119-126. PMID- 29410776 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200929 IS - 2000-8066 (Print) IS - 2000-8066 (Electronic) IS - 2000-8066 (Linking) VI - 9 IP - 1 DP - 2018 TI - Intensive prolonged exposure therapy for chronic PTSD patients following multiple trauma and multiple treatment attempts. PG - 1425574 LID - 10.1080/20008198.2018.1425574 [doi] LID - 1425574 AB - Background: Suboptimal response and high dropout rates leave room for improvement of trauma-focused treatment (TFT) effectiveness in ameliorating posttraumatic stress disorder (PTSD) symptoms. Objective: To explore the effectiveness and safety of intensive prolonged exposure (iPE) targeting chronic PTSD patients with a likely diagnosis of ICD-11 Complex PTSD following multiple interpersonal trauma and a history of multiple treatment attempts. Method: Participants (N = 73) received iPE in 12 × 90-minute sessions over four days (intensive phase) followed by four weekly 90-minute booster prolonged exposure (PE) sessions (booster phase). The primary outcomes, clinician-rated severity of PTSD symptoms, and diagnostic status (Clinician-Administered PTSD Scale; CAPS-IV) were assessed at baseline, post-treatment, and at three and six months. Treatment response trajectories were identified and predictors of these trajectories explored. Results: Mixed model repeated measures analysis of CAPS-IV scores showed a baseline-to-posttreatment decrease in PTSD symptom severity (p < .001) that persisted during the three- and six-month follow-ups with large effect sizes (Cohen's d > 1.2); 71% of the participants responded. None of the participants dropped out during the intensive phase and only 5% during the booster phase. Adverse events were extremely low and only a minority showed symptom exacerbation. Cluster analysis demonstrated four treatment response trajectories: Fast responders (13%), Slow responders (26%), Partial responders (32%), and Non-responders (29%). Living condition and between-session fear habituation were found to predict outcome. Participants living alone were more likely to belong to the Partial responders than to the Non-responders cluster, and participants showing more between-session fear habituation were more likely to belong to the Fast responders than to the Non-responders cluster. Conclusions: The results of this open study suggest that iPE can be effective in PTSD patients with multiple interpersonal trauma and after multiple previous treatment attempts. In addition, in this chronic PTSD population iPE was safe. FAU - Hendriks, Lotte AU - Hendriks L AD - Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care Pro Persona, Nijmegen, The Netherlands. AD - Behavioural Science Institute, NijCare, Radboud University, Nijmegen, The Netherlands. FAU - de Kleine, Rianne A AU - de Kleine RA AD - Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care Pro Persona, Nijmegen, The Netherlands. AD -  Institute of Psychology, Leiden University, Leiden, The Netherlands. FAU - Broekman, Theo G AU - Broekman TG AD - Bureau Bêta, Nijmegen, The Netherlands. FAU - Hendriks, Gert-Jan AU - Hendriks GJ AUID- ORCID: 0000-0001-5529-3275 AD - Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care Pro Persona, Nijmegen, The Netherlands. AD - Behavioural Science Institute, NijCare, Radboud University, Nijmegen, The Netherlands. AD - Department of Psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands. FAU - van Minnen, Agnes AU - van Minnen A AD - Overwaal Centre of Expertise for Anxiety Disorders, OCD and PTSD, Institution for Integrated Mental Health Care Pro Persona, Nijmegen, The Netherlands. AD - Behavioural Science Institute, NijCare, Radboud University, Nijmegen, The Netherlands. AD - Psychotrauma Expertise Centre (PSYTREC), Bilthoven, The Netherlands. LA - eng PT - Journal Article DEP - 20180130 PL - United States TA - Eur J Psychotraumatol JT - European journal of psychotraumatology JID - 101559025 PMC - PMC5795659 OTO - NOTNLM OT - (complex) PTSD OT - (prolonged) exposure OT - intensive treatment OT - predictors OT - response patterns OT - treatment outcome OT - • Current trauma-focused treatment (TFT), including prolonged exposure (PE), usually lasts several months with sessions being delivered on a weekly basis.• In this study, PE is administered in an accelerated way in chronic PTSD patients with a likely diagnosis of ICD-11 Complex PTSD following multiple interpersonal trauma and a history of multiple treatment attempts.• The results of this open study suggest that intensive PE (iPE) can be effective. Although previous treatment attempts were unsuccessful in these patients, 71% showed partial or complete response during iPE. In addition, iPE was found to be safe and dropout rates were very low. COIS- The authors declare that there are no conflicts of interest. EDAT- 2018/02/08 06:00 MHDA- 2018/02/08 06:01 PMCR- 2018/01/30 CRDT- 2018/02/08 06:00 PHST- 2017/06/20 00:00 [received] PHST- 2017/12/23 00:00 [accepted] PHST- 2018/02/08 06:00 [entrez] PHST- 2018/02/08 06:00 [pubmed] PHST- 2018/02/08 06:01 [medline] PHST- 2018/01/30 00:00 [pmc-release] AID - 1425574 [pii] AID - 10.1080/20008198.2018.1425574 [doi] PST - epublish SO - Eur J Psychotraumatol. 2018 Jan 30;9(1):1425574. doi: 10.1080/20008198.2018.1425574. eCollection 2018. PMID- 38902765 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240623 IS - 1753-2000 (Print) IS - 1753-2000 (Electronic) IS - 1753-2000 (Linking) VI - 18 IP - 1 DP - 2024 Jun 20 TI - Acute response to the October 7th hostage release: rapid development and evaluation of the novel ReSPOND protocol implementation within a children's hospital. PG - 76 LID - 10.1186/s13034-024-00767-3 [doi] LID - 76 AB - BACKGROUND: The decision to allocate hospitals for the initial reception of hostages abducted on the October 7th Hamas attack introduced an array of unprecedented challenges. These challenges stemmed from a paucity of existing literature and protocols, lack of information regarding captivity conditions, and variability in hostage characteristics and circumstances. OBJECTIVE: To describe the rapid development, implementation and evaluation of the Hostage-ReSPOND protocol, a comprehensive trauma-informed procedure for the care of hostages, including young children, their caregivers and families, immediately following their release from prolonged captivity. METHODS: A multidisciplinary expert focus group conducted a comprehensive literature review to develop the ReSPOND protocol, consisting of: Readiness of teams via multifaceted trainings, utilizing live simulations and video debriefings; Specialized professional teams experienced in providing holistic trauma-informed care; Personalized care tailored to individualized and developmentally-informed needs; Optimal safety rooted in creating a secure environment and trauma-informed response to young children, adolescents, caregivers and families; and Navigating Discharge, through coordination with community-based care systems. RESULTS: A designated facility at the Children's hospital was carefully prepared for receiving 29 hostages, aged 3.9-80 years, 28% under the age of 18. Implementation of the ReSPOND protocol, which prioritized holistic psychosocial interventions above urgent medical care, proved feasible and effective in managing the diverse and complex needs of returnees as per provider report. Finally, systemic assessment of returnee's immediate and long-term mental health needs proved highly challenging. CONCLUSIONS: There is currently no literature addressing the response to released hostages, especially those involving infants, young children and families within a children's hospital facility. This study has the potential to fill a crucial gap in knowledge by introducing a novel protocol which could offer valuable insights for public health organizations tasked with providing acute care to diverse individuals and families experiencing extreme, multi-layered mass traumatization. CI - © 2024. The Author(s). FAU - de la Fontaine, Naama AU - de la Fontaine N AUID- ORCID: 0000-0003-0030-6774 AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. naama.delafontaine@yale.edu. AD - Child Study Center, Yale School of Medicine, New Haven, CT, USA. naama.delafontaine@yale.edu. FAU - Silberg, Tamar AU - Silberg T AUID- ORCID: 0000-0002-8549-4948 AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. FAU - Fegert, Jörg M AU - Fegert JM AD - Department for Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Competence Domain Mental Health Prevention, Ulm, Germany. FAU - Tsafrir, Shlomit AU - Tsafrir S AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Weisman, Hana AU - Weisman H AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. FAU - Rubin, Noa AU - Rubin N AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. FAU - Ashkenazi, Moshe AU - Ashkenazi M AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Nacasch, Nitsa AU - Nacasch N AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. AD - Sheba Medical Center, Ramat Gan, Israel. FAU - Polliack, Michael L AU - Polliack ML AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. AD - Sheba Medical Center, Ramat Gan, Israel. FAU - Chen, Wendy AU - Chen W AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - Department of Social Services, Sheba Medical Center, Ramat Gan, Israel. FAU - Herman-Raz, Meirav AU - Herman-Raz M AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - Department of Social Services, Sheba Medical Center, Ramat Gan, Israel. FAU - Wachsberg-Lachmanovich, Ronit AU - Wachsberg-Lachmanovich R AD - Sheba Medical Center, Ramat Gan, Israel. FAU - Pessach-Gelblum, Liat AU - Pessach-Gelblum L AD - MSR-Israel Center for Medical Simulation, Sheba Medical Center, Ramat Gan, Israel. FAU - Ziv, Amitai AU - Ziv A AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. AD - MSR-Israel Center for Medical Simulation, Sheba Medical Center, Ramat Gan, Israel. FAU - Moshkovitz, Anat AU - Moshkovitz A AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. FAU - Shilo, Noya AU - Shilo N AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. AD - Sheba Medical Center, Ramat Gan, Israel. FAU - Frenkel-Nir, Yael AU - Frenkel-Nir Y AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. AD - Sheba Medical Center, Ramat Gan, Israel. FAU - Gothelf, Doron AU - Gothelf D AUID- ORCID: 0000-0001-9305-5382 AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - Sagol School of Neuroscience, The Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Pessach, Itai M AU - Pessach IM AUID- ORCID: 0000-0002-4575-6704 AD - The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Derech Sheba 2, Ramat Gan, 5262656, Israel. AD - The Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20240620 PL - England TA - Child Adolesc Psychiatry Ment Health JT - Child and adolescent psychiatry and mental health JID - 101297974 PMC - PMC11191208 OTO - NOTNLM OT - Acute response OT - Acute trauma protocol OT - Child abduction OT - Childhood trauma OT - Hospital disaster response OT - Hostages OT - Multilayered trauma OT - Parent trauma OT - Trauma COIS- The authors declare no competing interests. EDAT- 2024/06/21 00:42 MHDA- 2024/06/21 00:43 PMCR- 2024/06/20 CRDT- 2024/06/20 23:40 PHST- 2024/04/22 00:00 [received] PHST- 2024/06/10 00:00 [accepted] PHST- 2024/06/21 00:43 [medline] PHST- 2024/06/21 00:42 [pubmed] PHST- 2024/06/20 23:40 [entrez] PHST- 2024/06/20 00:00 [pmc-release] AID - 10.1186/s13034-024-00767-3 [pii] AID - 767 [pii] AID - 10.1186/s13034-024-00767-3 [doi] PST - epublish SO - Child Adolesc Psychiatry Ment Health. 2024 Jun 20;18(1):76. doi: 10.1186/s13034-024-00767-3. PMID- 22074008 OWN - NLM STAT- MEDLINE DCOM- 20120228 LR - 20111114 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) VI - 14 Suppl 2 DP - 2011 Dec TI - Taking an integrated approach: managing women with phytoestrogens. PG - 2-7 LID - 10.3109/13697137.2011.626367 [doi] AB - An integrated approach can be employed when counselling women about menopausal management options, where lifestyle, complementary therapies and hormone replacement therapy (HRT) are discussed. Women might opt to use an alternative approach to HRT for a variety of reasons, e.g. fear of side-effects and risks or contraindications to HRT. There are many choices of dietary and herbal approaches for menopausal symptoms, which essentially divide into food supplements and herbal medicines. The choice can often be overwhelming and confusing for the woman. Of concern, the evidence for efficacy and safety of some of these complementary therapies can be extremely limited or non-existent. In order to enable women to make a fully informed choice, it is important that, when a recommendation is made regarding a specific complementary therapy, it should focus on preparations for which a significant dataset exists for efficacy and safety and in which there is ongoing research and development. One of the most extensively studied food supplements has been the phytoestrogenic preparation containing red clover isoflavones. There have been six randomized trials thus far studying the impact on vasomotor symptoms, three of which have shown a significant benefit compared to placebo. There are also data from small randomized and observational trials showing positive outcomes for surrogate markers of osteoporosis and cardiovascular disease. A recent study using validated depression scales has shown that women using red clover isoflavones may also derive psychological benefits. Safety data are reassuring for the endometrium and breast, although further studies would be welcome, particularly in women with significant medical risks. FAU - Panay, N AU - Panay N AD - Queen Charlotte's & Chelsea and Chelsea & Westminster Hospitals and Honorary Senior Lecturer, Imperial College London, London, UK. LA - eng PT - Journal Article PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 RN - 0 (Isoflavones) RN - 0 (Phytoestrogens) RN - 0 (Placebos) SB - IM MH - Breast MH - Cardiovascular Diseases MH - Complementary Therapies MH - Dietary Supplements MH - Endometrium MH - Female MH - Hot Flashes/drug therapy MH - Humans MH - Isoflavones/adverse effects/*therapeutic use MH - *Menopause/psychology MH - Osteoporosis, Postmenopausal MH - Phytoestrogens/adverse effects/*therapeutic use MH - Phytotherapy MH - Placebos MH - Randomized Controlled Trials as Topic MH - Trifolium/chemistry EDAT- 2011/12/07 06:00 MHDA- 2012/03/01 06:00 CRDT- 2011/11/15 06:00 PHST- 2011/11/15 06:00 [entrez] PHST- 2011/12/07 06:00 [pubmed] PHST- 2012/03/01 06:00 [medline] AID - 10.3109/13697137.2011.626367 [doi] PST - ppublish SO - Climacteric. 2011 Dec;14 Suppl 2:2-7. doi: 10.3109/13697137.2011.626367. PMID- 22230590 OWN - NLM STAT- MEDLINE DCOM- 20120626 LR - 20161125 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 30 IP - 10 DP - 2012 Feb 27 TI - U.K. parents' decision-making about measles-mumps-rubella (MMR) vaccine 10 years after the MMR-autism controversy: a qualitative analysis. PG - 1855-64 LID - 10.1016/j.vaccine.2011.12.127 [doi] AB - BACKGROUND AND OBJECTIVES: Public concern about an unsubstantiated link between MMR vaccine and autism stemmed from a 1998 paper by Dr Andrew Wakefield and colleagues, and the substantial media coverage which that work attracted. Though the Wakefield paper is now discredited and an MMR-autism link has never been demonstrated empirically, this concern has manifested in over a decade of suboptimal MMR uptake. Few qualitative studies have explored parents' MMR decision-making since uptake began to improve in 2004. This study updates and adds methodological rigour to the evidence base. METHODS: 24 mothers planning to accept, postpone or decline the first MMR dose (MMR1) for their 11-36 month-old children, described their decision-making in semi-structured interviews. Mothers were recruited via General Practice, parents' groups/online forums, and chain referral. MMR1 status was obtained from General Practice records 6 months post-interview. Interview transcripts were coded and interpreted using a modified Grounded Theory approach. RESULTS: Five themes were identified: MMR vaccine and controversy; Social and personal consequences of MMR decision; Health professionals and policy; Severity and prevalence of measles, mumps and rubella infections; Information about MMR and alternatives. Results indicated that MMR1 acceptors were sympathetic toward Wakefield as a person, but universally rejected his study which sparked the controversy; parents opting for single vaccines expressed the sense that immune overload is not a consideration but that not all three components of MMR are warranted by disease severity; and MMR1 rejectors openly criticised other parents' MMR decisions and decision-making. CONCLUSIONS: This study corroborated some previous qualitative work but indicated that the shrinking group of parents now rejecting MMR comprises mainly those with more extreme and complex anti-immunisation views, whilst parents opting for single vaccines may use second-hand information about the controversy. In response, policymakers and practitioners should revise their expectations of today's MMR decision-makers, and their methods for supporting them. CI - Copyright © 2012 Elsevier Ltd. All rights reserved. FAU - Brown, Katrina F AU - Brown KF AD - Centre for Patient Safety and Service Quality, Imperial College London, St. Mary's Campus, London W2 1PG, UK. Katrina.Brown@imperial.ac.uk FAU - Long, Susannah J AU - Long SJ FAU - Ramsay, Mary AU - Ramsay M FAU - Hudson, Michael J AU - Hudson MJ FAU - Green, John AU - Green J FAU - Vincent, Charles A AU - Vincent CA FAU - Kroll, J Simon AU - Kroll JS FAU - Fraser, Graham AU - Fraser G FAU - Sevdalis, Nick AU - Sevdalis N LA - eng GR - Department of Health/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120109 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Measles-Mumps-Rubella Vaccine) SB - IM MH - Adult MH - Autistic Disorder/epidemiology MH - *Decision Making MH - *Health Knowledge, Attitudes, Practice MH - Humans MH - Measles-Mumps-Rubella Vaccine/*administration & dosage MH - Mothers/psychology MH - *Patient Acceptance of Health Care MH - United Kingdom MH - Vaccination/*psychology EDAT- 2012/01/11 06:00 MHDA- 2012/06/27 06:00 CRDT- 2012/01/11 06:00 PHST- 2011/06/13 00:00 [received] PHST- 2011/11/27 00:00 [revised] PHST- 2011/12/27 00:00 [accepted] PHST- 2012/01/11 06:00 [entrez] PHST- 2012/01/11 06:00 [pubmed] PHST- 2012/06/27 06:00 [medline] AID - S0264-410X(11)02088-3 [pii] AID - 10.1016/j.vaccine.2011.12.127 [doi] PST - ppublish SO - Vaccine. 2012 Feb 27;30(10):1855-64. doi: 10.1016/j.vaccine.2011.12.127. Epub 2012 Jan 9. PMID- 23106672 OWN - NLM STAT- MEDLINE DCOM- 20130909 LR - 20151119 IS - 1525-1470 (Electronic) IS - 0736-8046 (Linking) VI - 29 IP - 6 DP - 2012 Nov-Dec TI - Quality of life of parents living with a child suffering from atopic dermatitis before and after a 3-month treatment with an emollient. PG - 714-8 LID - 10.1111/j.1525-1470.2012.01817.x [doi] AB - Atopic dermatitis (AD) can be extremely disabling and may cause psychological problems for affected children and their families. Moisturizers and emollients are important in the baseline daily skin care of patients with AD. To assess the effect of a 3-month, twice-daily treatment with an emollient on the quality of life (QoL) of parents with a child with mild to moderate AD (SCORing Atopic Dermatitis [SCORAD] ≤ 30, a multicenter open trial was performed by eight dermatologists on 191 volunteers. Evaluation by the dermatologist of the child's clinical condition (SCORAD) and of the efficacy and overall safety of the treatment was associated with a QoL questionnaire completed by one parent of the atopic child. A self-assessment of the global QoL and of the efficacy and overall safety was also performed. During the study, mean SCORAD dropped from 28 to 12 (p < 0.001), with good improvement in skin dryness and pruritus criteria. At the same time, the self-assessment of the global parent QoL scores dropped from 4.4 to 2.1 (p < 0.001) with 60%, 48% and 79% favorable parent opinions regarding wellbeing or improvement of the health condition, quality of sleep, and efficacy of the emollient, respectively. This trial revealed the efficacy of the product in improving parent QoL (85% of parents noted improvement in QoL), and its global safety was considered to be very good or good, with 80% favorable opinions in parents' declarative judgements and dermatologists' assessments. The emollient evaluated improves the course of AD and can improve the QoL of patients and their families. CI - © 2012 Wiley Periodicals, Inc. FAU - Gelmetti, Carlo AU - Gelmetti C AD - Scienze Dermatologiche, Università degli Studi di Milano, Fondazione IRCSS Ospedale Maggiore Policlinico, Milan, Italy. carlo.gelmetti@unimi.it FAU - Boralevi, Franck AU - Boralevi F FAU - Seité, Sophie AU - Seité S FAU - Grimalt, Ramon AU - Grimalt R FAU - Humbert, Philippe AU - Humbert P FAU - Luger, Thomas AU - Luger T FAU - Stalder, Jean-Francois AU - Stalder JF FAU - Taïeb, Alain AU - Taïeb A FAU - Tennstedt, Dominique AU - Tennstedt D FAU - Garcia Diaz, Rita AU - Garcia Diaz R FAU - Rougier, André AU - Rougier A LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PL - United States TA - Pediatr Dermatol JT - Pediatric dermatology JID - 8406799 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Emollients) RN - 0 (Oleic Acids) RN - 0 (Plant Oils) RN - 0 (shea oleine) SB - IM MH - Administration, Topical MH - Adrenal Cortex Hormones/administration & dosage MH - Adult MH - Child MH - Child, Preschool MH - Dermatitis, Atopic/*drug therapy/*psychology MH - Emollients/*administration & dosage MH - *Family Health MH - Female MH - Humans MH - Infant MH - Male MH - Oleic Acids/*administration & dosage MH - Parent-Child Relations MH - Plant Oils/*administration & dosage MH - Quality of Life/*psychology MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Treatment Outcome EDAT- 2012/10/31 06:00 MHDA- 2013/09/10 06:00 CRDT- 2012/10/31 06:00 PHST- 2012/10/31 06:00 [entrez] PHST- 2012/10/31 06:00 [pubmed] PHST- 2013/09/10 06:00 [medline] AID - 10.1111/j.1525-1470.2012.01817.x [doi] PST - ppublish SO - Pediatr Dermatol. 2012 Nov-Dec;29(6):714-8. doi: 10.1111/j.1525-1470.2012.01817.x. PMID- 15129201 OWN - NLM STAT- MEDLINE DCOM- 20040826 LR - 20131121 IS - 0161-4754 (Print) IS - 0161-4754 (Linking) VI - 27 IP - 3 DP - 2004 Mar-Apr TI - Effect of a back belt on reaching postures. PG - 186-96 AB - OBJECTIVE: The present study investigated the effect of a back belt on reach actions. SUBJECTS: Sixteen undergraduate college students (8 male students, 8 female students) ranging in age from 18 to 22 years. Thirteen subjects were included in the final analysis. SETTING: The Department of Psychology at Miami University, Oxford, Ohio METHODS: Using a well-established set of procedures developed in our laboratory for studying reaching, seated adult participants reached for and retrieved an object placed at various distances from them. Reach distances included values both closer than and farther than each subject's maximum seated reach. The reach task had 2 conditions: picking up and retrieving a small block and skewering and retrieving a small bead with a needle. For each task condition, each subject either wore the belt or did not use a belt. RESULTS: Results indicate that when subjects wore the belt while reaching, they tended to have initial transition points (sitting to nonsitting) closer to their bodies than while not wearing the belt. That is, for a distant object, subjects were more likely to raise their bodies out of the chair rather than perform an extreme seated reach, possibly acting to preserve a greater margin of safety. CONCLUSIONS: The back belt consistently modified reaching postures by limiting extreme ranges of motion during a task that required enhanced stability. Furthermore, the methodology and analysis presented in this article when applied to chiropractic will allow us to begin thoughtful investigation of the effects of chiropractic adjustments on postural transitions and margin of safety. FAU - Smith, Dean L AU - Smith DL AD - Center for Ergonomic Research, Department of Psychology, Miami University, Oxford, Ohio, USA. drdean@essenceofwellness.com FAU - Dainoff, Marvin J AU - Dainoff MJ FAU - Mark, Leonard S AU - Mark LS FAU - Oates, Shawn P AU - Oates SP FAU - Davis, Niles C AU - Davis NC LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Manipulative Physiol Ther JT - Journal of manipulative and physiological therapeutics JID - 7807107 SB - IM MH - Adult MH - Analysis of Variance MH - Biomechanical Phenomena MH - Chiropractic/*standards MH - Female MH - Humans MH - Lumbosacral Region/physiology MH - Male MH - Manipulation, Chiropractic/standards MH - Movement/physiology MH - Ohio MH - *Orthotic Devices/standards MH - *Posture MH - *Protective Devices/standards MH - *Range of Motion, Articular EDAT- 2004/05/07 05:00 MHDA- 2004/08/27 05:00 CRDT- 2004/05/07 05:00 PHST- 2004/05/07 05:00 [pubmed] PHST- 2004/08/27 05:00 [medline] PHST- 2004/05/07 05:00 [entrez] AID - S0161475403002501 [pii] AID - 10.1016/j.jmpt.2003.12.028 [doi] PST - ppublish SO - J Manipulative Physiol Ther. 2004 Mar-Apr;27(3):186-96. doi: 10.1016/j.jmpt.2003.12.028. PMID- 7989055 OWN - NLM STAT- MEDLINE DCOM- 19950109 LR - 20220318 IS - 0018-7208 (Print) IS - 0018-7208 (Linking) VI - 36 IP - 3 DP - 1994 Sep TI - Influencing of warning label signal words on perceived hazard level. PG - 547-56 AB - This experiment investigated the influence of warnings, signal words, and a signal icon on perceived hazard of consumer products. Under the guise of a marketing research study, 135 people (high school students, college students, and participants from a shopping mall) rated product labels on six dimensions, including how hazardous they perceived the products to be. A total of 16 labels from actual household products were used: 9 carried the experimental conditions, and 7 were filler product labels that never carried a warning. Five conditions presented the signal words NOTE, CAUTION, WARNING, DANGER, and LETHAL together with a brief warning message. In another two conditions, a signal icon (exclamation point surrounded by a triangle) was presented together with the terms DANGER and LETHAL. In the final two conditions, one lacked a signal word but retained the warning message, and the other lacked both the warning message and the signal word. Results showed that the presence of a signal word increased perceived product hazard compared with its absence. Significant differences were noted between extreme terms (e.g., NOTE and DANGER) but not between terms usually recommended in warning design guidelines (e.g., CAUTION and WARNING). The signal icon showed no significant effect on hazard perception. Implications of the results and the value of the methodology for future warnings investigations are discussed. FAU - Wogalter, M S AU - Wogalter MS AD - Psychology Department, North Carolina State University, Raleigh 27695. FAU - Jarrard, S W AU - Jarrard SW FAU - Simpson, S N AU - Simpson SN LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Attention MH - Female MH - Humans MH - Male MH - Middle Aged MH - Psychophysics MH - *Reading MH - *Safety Management EDAT- 1994/09/01 00:00 MHDA- 1994/09/01 00:01 CRDT- 1994/09/01 00:00 PHST- 1994/09/01 00:00 [pubmed] PHST- 1994/09/01 00:01 [medline] PHST- 1994/09/01 00:00 [entrez] AID - 10.1177/001872089403600310 [doi] PST - ppublish SO - Hum Factors. 1994 Sep;36(3):547-56. doi: 10.1177/001872089403600310. PMID- 33013090 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240801 IS - 0974-2700 (Print) IS - 0974-519X (Electronic) IS - 0974-2700 (Linking) VI - 13 IP - 2 DP - 2020 Apr-Jun TI - Face to Face with Coronavirus Disease 19: Maintaining Motivation, Psychological Safety, and Wellness. PG - 116-123 LID - 10.4103/JETS.JETS_27_20 [doi] AB - Emerging infectious diseases have the potential to spread across borders extremely quickly. This was seen during the severe acute respiratory syndrome (SARS) outbreak and now, coronavirus disease (COVID 19) (novel coronavirus) pandemic. For outbreaks and pandemics, there will be behavioral, affective, and cognitive changes and adaptation seen. This may be prominent in frontline workers and healthcare workers (HCWs), who work in high-risk areas, as well as people in general. What represents the psychology and mindset of people during a pandemic? What is needed to allay anxieties and instill calm? What will be needed to keep the motivation levels of people and HCW high so that they continue to function optimally? Which motivation theory can be used to explain this and how do employers and management utilize this in their approach/strategies in planning for an outbreak? Finally, the impact of culture, in the various contexts, cannot be overlooked in crisis and pandemic management. The author is a senior emergency physician in Singapore, who has been through SARS and now the COVID pandemic. She has been instrumental in sharing some of the changes and practices implemented in Singapore, since SARS 17 years ago, until now. Besides being a full-time practicing emergency physician, the author is also an elected Member of the Singapore Parliament for the last 14 years. She shares her views on an aspect often overlooked during a pandemic: psychological wellness and motivations of people, including for HCW at the frontline. CI - Copyright: © 2020 Journal of Emergencies, Trauma, and Shock. FAU - Lateef, Fatimah AU - Lateef F AD - Department of Emergency Medicine, Singapore General Hospital, Singapore. AD - Adjunct Professor, Duke NUS Graduate Medical School, Singapore. AD - Adjunct Professor, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. AD - Singhealth Duke NUS Institute of Medical Simulation, Singapore. AD - Founding and Board Member, World Academic Council in Emergency Medicine, Singapore. LA - eng PT - Journal Article DEP - 20200610 PL - India TA - J Emerg Trauma Shock JT - Journal of emergencies, trauma, and shock JID - 101493921 PMC - PMC7472823 OTO - NOTNLM OT - Coronavirus disease 19 OT - emerging infectious diseases OT - motivation OT - pandemic OT - psychological wellness COIS- There are no conflicts of interest. EDAT- 2020/10/06 06:00 MHDA- 2020/10/06 06:01 PMCR- 2020/04/01 CRDT- 2020/10/05 06:13 PHST- 2020/02/27 00:00 [received] PHST- 2020/03/31 00:00 [revised] PHST- 2020/03/12 00:00 [accepted] PHST- 2020/10/05 06:13 [entrez] PHST- 2020/10/06 06:00 [pubmed] PHST- 2020/10/06 06:01 [medline] PHST- 2020/04/01 00:00 [pmc-release] AID - JETS-13-116 [pii] AID - 10.4103/JETS.JETS_27_20 [doi] PST - ppublish SO - J Emerg Trauma Shock. 2020 Apr-Jun;13(2):116-123. doi: 10.4103/JETS.JETS_27_20. Epub 2020 Jun 10. PMID- 25463918 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20181113 IS - 1873-2054 (Electronic) IS - 1353-8292 (Print) IS - 1353-8292 (Linking) VI - 31 DP - 2015 Jan TI - Re-thinking children's agency in extreme hardship: Zimbabwean children's draw-and-write about their HIV-affected peers. PG - 54-64 LID - S1353-8292(14)00138-5 [pii] LID - 10.1016/j.healthplace.2014.09.008 [doi] AB - We compare two analyses of the same 'draw-and-write' exercises in which 128 Zimbabwean children represented their HIV-affected peers. The first, informed by the 'New Social Studies of Childhood', easily identified examples of independent reflection and action by children. The second, informed by Sen's understandings of agency, drew attention to the negative consequences of many of the choices available to children, and the contextual limits on outcomes children themselves would value: the support of caring adults, adequate food, and opportunities to advance their health and safety. Conceptualisations of agency need to take greater account of children's own accounts of outcomes they value, rather than identifying agency in any form of independent reflection and action per se. CI - Copyright © 2014. Published by Elsevier Ltd. FAU - Campbell, Catherine AU - Campbell C AD - Department of Social Psychology, The London School of Economics and Political Science, London WC2A 2AE, United Kingdom. Electronic address: c.campbell@lse.ac.uk. FAU - Andersen, Louise AU - Andersen L AD - Department of Social Psychology, The London School of Economics and Political Science, London WC2A 2AE, United Kingdom. Electronic address: l.b.andersen@lse.ac.uk. FAU - Mutsikiwa, Alice AU - Mutsikiwa A AD - Biomedical Research and Training Institute, Harare, Zimbabwe. Electronic address: mutsikiwaa@yahoo.com. FAU - Madanhire, Claudius AU - Madanhire C AD - School of Applied Human Sciences, University of KwaZulu Natal, Durban, South Africa. Electronic address: cmadanhire@gmail.com. FAU - Skovdal, Morten AU - Skovdal M AD - Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Electronic address: m.skovdal@gmail.com. FAU - Nyamukapa, Constance AU - Nyamukapa C AD - Department of Infectious Disease Epidemiology, Imperial College School of Public Health, London SW7 2AZ, United Kingdom. Electronic address: nyamukapaconnie@gmail.com. FAU - Gregson, Simon AU - Gregson S AD - Department of Infectious Disease Epidemiology, Imperial College School of Public Health, London SW7 2AZ, United Kingdom. Electronic address: Sajgregson@aol.com. LA - eng GR - 084401/Wellcome Trust/United Kingdom PT - Comparative Study PT - Journal Article DEP - 20141125 PL - England TA - Health Place JT - Health & place JID - 9510067 MH - *Art MH - Child MH - Female MH - HIV Infections/*psychology MH - Humans MH - Male MH - *Peer Group MH - Social Perception MH - Stereotyping MH - *Writing MH - Zimbabwe PMC - PMC4783859 MID - EMS67334 OID - NLM: EMS67334 OTO - NOTNLM OT - Agency OT - Children OT - HIV/AIDS OT - Zimbabwe EDAT- 2014/12/03 06:00 MHDA- 2016/12/15 06:00 PMCR- 2016/03/09 CRDT- 2014/12/03 06:00 PHST- 2014/01/01 00:00 [received] PHST- 2014/09/13 00:00 [revised] PHST- 2014/09/14 00:00 [accepted] PHST- 2014/12/03 06:00 [entrez] PHST- 2014/12/03 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PHST- 2016/03/09 00:00 [pmc-release] AID - S1353-8292(14)00138-5 [pii] AID - 10.1016/j.healthplace.2014.09.008 [doi] PST - ppublish SO - Health Place. 2015 Jan;31:54-64. doi: 10.1016/j.healthplace.2014.09.008. Epub 2014 Nov 25. PMID- 29980362 OWN - NLM STAT- MEDLINE DCOM- 20181219 LR - 20241127 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 65 DP - 2018 Oct TI - The Australian Nurse-Family Partnership Program for aboriginal mothers and babies: Describing client complexity and implications for program delivery. PG - 72-81 LID - S0266-6138(18)30190-6 [pii] LID - 10.1016/j.midw.2018.06.019 [doi] AB - CONTEXT: The Australian Nurse-Family Partnership Program is a home visiting program for Aboriginal mothers and infants (pregnancy to child's second birthday) adapted from the US Nurse Family Partnership program. It aims to improve outcomes for Australian Aboriginal mothers and babies, and disrupt intergenerational cycles of poor health and social and economic disadvantage. The aim of this study was to describe the complexity of Program clients in the Central Australian family partnership program, understand how client complexity affects program delivery and the implications for desirable program modification. METHODS: Australian Nurse-Family Partnership Program data collected using standardised data forms by nurses during pregnancy home visits (n = 276 clients from 2009 to 2015) were used to describe client complexity and adversity in relation to demographic and economic characteristics, mental health and personal safety. Semi-structured interviews with 11 Australian Nurse-Family Partnership Program staff and key stakeholders explored in more depth the nature of client adversity and how this affected Program delivery. FINDINGS: Most clients were described as "complicated" being exposed to extreme poverty (66% on welfare), living with insecure housing, many experiencing domestic violence (almost one third experiencing 2 + episodes of violence in 12 months). Sixty-six percent of clients had experienced four or more adversities. These adversities were found challenging for Program delivery. For example, housing conditions mean that around half of all 'home visits' could not be conducted in the home (held instead in staff cars or community locations) and together with exposure to violence undermined client capacity to translate program learnings into action. Crises with the basics of living regularly intruded into the delivery of program content, and low client literacy meant written hand-outs were unhelpful for many, requiring the development of pictorial-based program materials. Adversity increased the time needed to deliver program content. CONCLUSIONS: Modifications to the Australian Nurse-Family Partnership Program model to reflect the specific complexities and adversities faced by the client populations is important for effective service delivery and to maximise the chance of meeting program goals of improving the health and well-being of Australian Aboriginal mothers and their infants. CI - Copyright © 2018 Elsevier Ltd. All rights reserved. FAU - Zarnowiecki, Dorota AU - Zarnowiecki D AD - Health Economics and Social Policy Research Group, Centre for Population Health, School of Health Sciences, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. FAU - Nguyen, Ha AU - Nguyen H AD - Health Economics and Social Policy Research Group, Centre for Population Health, School of Health Sciences, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. FAU - Catherine Hampton AU - Catherine Hampton AD - Australian Nurse-Family Partnership Program, Central Australian Aboriginal Congress Aboriginal Corporation, Australia. FAU - Boffa, John AU - Boffa J AD - Central Australian Aboriginal Congress Aboriginal Corporation, Australia. FAU - Segal, Leonie AU - Segal L AD - Health Economics and Social Policy Research Group, Centre for Population Health, School of Health Sciences, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. Electronic address: leonie.segal@unisa.edu.au. LA - eng PT - Journal Article DEP - 20180623 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 MH - Adolescent MH - Adult MH - Australia MH - Domestic Violence/statistics & numerical data MH - Female MH - *Healthcare Disparities MH - Ill-Housed Persons/psychology/statistics & numerical data MH - Humans MH - Infant, Newborn MH - *Nurse-Patient Relations MH - Nurses, Community Health/*organization & administration MH - Poverty/statistics & numerical data MH - Pregnancy MH - Prenatal Care/*methods MH - Program Development MH - Qualitative Research MH - Risk Factors MH - Young Adult OTO - NOTNLM OT - Aboriginal health OT - Maternal child health service OT - Nurse home visiting OT - Nurse-Family Partnership EDAT- 2018/07/08 06:00 MHDA- 2018/12/20 06:00 CRDT- 2018/07/08 06:00 PHST- 2018/02/20 00:00 [received] PHST- 2018/05/13 00:00 [revised] PHST- 2018/06/17 00:00 [accepted] PHST- 2018/07/08 06:00 [pubmed] PHST- 2018/12/20 06:00 [medline] PHST- 2018/07/08 06:00 [entrez] AID - S0266-6138(18)30190-6 [pii] AID - 10.1016/j.midw.2018.06.019 [doi] PST - ppublish SO - Midwifery. 2018 Oct;65:72-81. doi: 10.1016/j.midw.2018.06.019. Epub 2018 Jun 23. PMID- 21999176 OWN - NLM STAT- MEDLINE DCOM- 20120123 LR - 20220408 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 11 DP - 2011 Oct 14 TI - An open-label, multicenter study to evaluate the safe and effective use of the single-use autoinjector with an Avonex® prefilled syringe in multiple sclerosis subjects. PG - 126 LID - 10.1186/1471-2377-11-126 [doi] AB - BACKGROUND: The ability to self-inject in patients with multiple sclerosis (MS) has been associated with a reduced risk of missed injections and drug discontinuation, and a beneficial effect on patients' independence. However, injection anxiety, needle phobia and disease-related disability are major barriers to a patient's ability to self-administer treatment. Use of an autoinjector may improve patients' ability to self-inject. This study evaluated the safe and effective use of Avonex Pen™ (prefilled pen), a single use autoinjector, for intramuscular delivery of interferon beta-1a (IM IFNβ-1a, Avonex) in MS patients. METHODS: This was a Phase IIIb, open-label, single-country, multicenter trial in MS patients currently using IM IFNβ-1a prefilled syringes. Patients received weekly 30 mcg IM IFNβ-1a treatment over 4 weeks. On Day 1, patients self-administered IM IFNβ-1a using a prefilled syringe at the clinic. On Day 8, patients received training on the prefilled pen and self-administered IM IFNβ-1a using the device. On Day 15, patients self-administered IM IFNβ-1a at home using the prefilled pen. A final injection occurred at the clinic on Day 22 when patients self-administered IM IFNβ-1a using the prefilled pen while clinic staff observed and completed a detailed questionnaire documenting patients' ability to self-inject with the device. Serum neopterin levels were evaluated pre and post-injection on Days 1 and 8. Adverse events were monitored throughout. RESULTS: Seventy-one (96%) patients completed the study. The overall success rate in safely and effectively using the prefilled pen was 89%. No device malfunctions occurred. One unsuccessful administration occurred at Day 22 due to patient error; no patient injury resulted. Patients gave the prefilled pen high ratings (8.7-9.3) on a 10-point scale for ease of use (0 = extremely difficult, 10 = extremely easy). Ninety-four percent of patients preferred the prefilled pen over the prefilled syringe. Induction of serum neopterin levels, serving as a biomarker for type 1 interferon action, was similar to that of the prefilled syringe. The prefilled pen demonstrated a safety profile comparable to the prefilled syringe. CONCLUSIONS: The prefilled pen is a safe and effective device for administration of IM IFNβ-1a and represents an alternative method for self-injection for MS patients using this therapy. TRIAL REGISTRATION: This study is registered at clinicaltrials.gov, identifier: NCT00828204. FAU - Phillips, J Theodore AU - Phillips JT AD - Texas Neurology, 6301 Gaston Ave, West Tower, #100, Dallas, Texas, USA. FAU - Fox, Edward AU - Fox E FAU - Grainger, William AU - Grainger W FAU - Tuccillo, Dianne AU - Tuccillo D FAU - Liu, Shifang AU - Liu S FAU - Deykin, Aaron AU - Deykin A LA - eng SI - ClinicalTrials.gov/NCT00828204 PT - Clinical Trial, Phase III PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20111014 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (Adjuvants, Immunologic) RN - 0 (Biomarkers, Pharmacological) RN - 670-65-5 (Neopterin) RN - 77238-31-4 (Interferon-beta) RN - XRO4566Q4R (Interferon beta-1a) SB - IM MH - Adjuvants, Immunologic/administration & dosage/adverse effects/*therapeutic use MH - Adult MH - Aged MH - Biomarkers, Pharmacological/blood MH - Female MH - Humans MH - Injections, Intramuscular/*instrumentation/*psychology MH - Interferon beta-1a MH - Interferon-beta/administration & dosage/adverse effects/*therapeutic use MH - Male MH - Middle Aged MH - Multiple Sclerosis/blood/*drug therapy/*psychology MH - Neopterin/blood MH - Patient Acceptance of Health Care/psychology/statistics & numerical data MH - Patient Preference/statistics & numerical data MH - Self Administration/methods/*psychology/statistics & numerical data MH - Syringes PMC - PMC3213083 EDAT- 2011/10/18 06:00 MHDA- 2012/01/24 06:00 PMCR- 2011/10/14 CRDT- 2011/10/18 06:00 PHST- 2011/07/26 00:00 [received] PHST- 2011/10/14 00:00 [accepted] PHST- 2011/10/18 06:00 [entrez] PHST- 2011/10/18 06:00 [pubmed] PHST- 2012/01/24 06:00 [medline] PHST- 2011/10/14 00:00 [pmc-release] AID - 1471-2377-11-126 [pii] AID - 10.1186/1471-2377-11-126 [doi] PST - epublish SO - BMC Neurol. 2011 Oct 14;11:126. doi: 10.1186/1471-2377-11-126. PMID- 19006026 OWN - NLM STAT- MEDLINE DCOM- 20090212 LR - 20151119 IS - 0022-9032 (Print) IS - 0022-9032 (Linking) VI - 66 IP - 10 DP - 2008 Oct TI - Psychological and clinical problems in young adults with implantable cardioverter-defibrillators. PG - 1050-8; discussion 1059-60 AB - BACKGROUND: Implantable cardioverter-defibrillators (ICD) are the most effective treatment in patients with the risk of sudden cardiac death. ICD improves patients' safety but is also the source of numerous inconveniences. Especially young people consider such ICD-related inconveniences as most unwelcome. AIM: To assess the quality of life and main psychological problems encountered in young adults with an ICD. METHODS: We studied 45 subjects aged 14-29 years (mean 21.2+/-4.3). ICDs were used in primary prevention in 22 patients, and in secondary prevention in 23 patients. Time elapsed from implantation ranged from 5 months to 11 years (4.3+/-2.7 years). Since the problems affecting this group were rather specific, the patients' quality of life was assessed with a special questionnaire addressing important issues and problems associated with living with an ICD. RESULTS: ICD discharges were observed in 67.4% of patients (primary prevention - 45.5%, secondary prevention - 82.6%), multiple shocks in 47.2%, and phantom shocks in 21.4%. Anxiety associated with an ICD discharge was reported by 84.4% of patients. In order to prevent ICD discharges, 53.3% of patients decreased their activity. Problems with memory were observed in 42.2% of patients, with concentration in 47.6%, and with sleep in 42.2%. Almost half of those over 18 years of age were active drivers. None of the subjects experienced an ICD discharge during sexual intercourse. None of the men reported any sexual problems, while seven (41.2%) women did. Almost a quarter of the patients claimed to have had complications after the implantation. Young adult patients generally were compliant to have their ICD checked and accepted their limitations and disease. Fewer people assessed their health status as bad. Some patients in the group studied found it extremely difficult to accept their disease and/or ICD and to adapt to the situation. As many as nine patients believed the ICD implantation had been unnecessary, seven did not accept the ICD, three patients thought negatively of follow-up visits, three were not compliant, 13 did not accept the limitations, four refused to accept the fact that their disease existed, and seven refused to do anything. At least four patients talked or thought about having the ICD removed. CONCLUSIONS: Patients with ICD have problems in different spheres of their activity (physical, psychological, and social). Such patients need to be informed appropriately about the ICD itself and its functioning. They should be granted psychological support from health professionals who are familiar with the specific problems of ICD recipients. FAU - Wójcicka, Mariola AU - Wójcicka M AD - Institute of Cardiology, 2nd Coronary Artery Disease Department, Warsaw, tel, Poland. mariolaw@orange.pl FAU - Lewandowski, Michał AU - Lewandowski M FAU - Smolis-Bak, Edyta AU - Smolis-Bak E FAU - Szwed, Hanna AU - Szwed H LA - eng PT - Journal Article PL - Poland TA - Kardiol Pol JT - Kardiologia polska JID - 0376352 SB - IM MH - *Activities of Daily Living MH - Adaptation, Psychological MH - Adolescent MH - Arrhythmias, Cardiac/*psychology/therapy MH - Defibrillators, Implantable/*psychology MH - Female MH - Humans MH - Male MH - Patient Compliance/*psychology MH - Poland MH - Professional-Patient Relations MH - *Quality of Life MH - Social Support MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - Young Adult EDAT- 2008/11/14 09:00 MHDA- 2009/02/13 09:00 CRDT- 2008/11/14 09:00 PHST- 2008/11/14 09:00 [pubmed] PHST- 2009/02/13 09:00 [medline] PHST- 2008/11/14 09:00 [entrez] AID - 11235 [pii] PST - ppublish SO - Kardiol Pol. 2008 Oct;66(10):1050-8; discussion 1059-60. PMID- 26736233 OWN - NLM STAT- MEDLINE DCOM- 20161011 LR - 20200928 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2015 DP - 2015 TI - Psycho-physiological tele-monitoring of human operators in commercial diving: The Life Support System in the SUONO project. PG - 194-7 LID - 10.1109/EMBC.2015.7318333 [doi] AB - Sea-diving operations for monitoring or intervention are carried out by highly-specialized divers called Certified Commercial Divers (CCD). CCDs operate under highly demanding working conditions in extreme and hazardous environments. Every day consists of an 8 hours' shift. To avoid decompression problems the remaining 16 hours are spent in a hyperbaric environment located aboard the surface vessel or on the platform. These operating conditions require the design of a technologically-advanced device for tele-monitoring, to maximize CCDs' safety. Here we describe a proposal for monitoring and supporting CCDs during operations. We design a dedicated Life Support System (LSS), that captures real-time, vital (heart rate, respiratory rate, accelerometry, etc) and stress-related (heart-rate variability) signals from operators to transmit them to dedicated servers via telematic protocols. LSS is equipped with protocols for tele-medicine/tele-consultation. Our system is being developed within the research project SUONO (Safe Underwater OperatioNs in Oceans). FAU - Laurino, Marco AU - Laurino M FAU - Guerriero, Lorenzo AU - Guerriero L FAU - Allegrini, Paolo AU - Allegrini P FAU - Menicucci, Danilo AU - Menicucci D FAU - Mastorci, Francesca AU - Mastorci F FAU - Magrin, Daniele AU - Magrin D FAU - Allotta, Benedetto AU - Allotta B FAU - Bedini, Remo AU - Bedini R FAU - Gemignani, Angelo AU - Gemignani A LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Diving/*physiology/*psychology MH - Equipment Design MH - Heart Rate MH - Humans MH - *Life Support Systems MH - Monitoring, Physiologic/instrumentation/*methods MH - Telemedicine/instrumentation/*methods EDAT- 2016/01/07 06:00 MHDA- 2016/10/12 06:00 CRDT- 2016/01/07 06:00 PHST- 2016/01/07 06:00 [entrez] PHST- 2016/01/07 06:00 [pubmed] PHST- 2016/10/12 06:00 [medline] AID - 10.1109/EMBC.2015.7318333 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:194-7. doi: 10.1109/EMBC.2015.7318333. PMID- 9050371 OWN - NLM STAT- MEDLINE DCOM- 19970507 LR - 20071114 IS - 0275-2565 (Print) IS - 0275-2565 (Linking) VI - 41 IP - 2 DP - 1997 TI - Pair-rearing infant monkeys (Macaca nemestrina) using a "rotating-peer" strategy. PG - 141-9 AB - Appropriate rearing conditions for captive primates are important for both research and breeding purposes. In an earlier study, pigtailed macaque infants that were pair-reared with a single continuous partner exhibited excessive social clinging and could not adapt to living in large social groups at 8-10 months of age. In the present study, eight macaques were pair-reared until they were 6 months old. Each member of an animal's four-monkey social group served as a home-cage partner. In an attempt to reduce excessive mutual clinging, the pairs were rotated every 2-3 days to increase the variability of social stimulation in the home cage. However, these infants developed abnormal social behaviors that were in some cases even more extreme than those exhibited by infants pair-reared with a single continuous partner. A second goal of this experiment was to study interlaboratory reliability for the development of social behavior. The animals were divided into two groups, one housed in a nursery and the other in a biological safety level 3 virus laboratory. Some differences were detected between the two groups, demonstrating the necessity of controls in biobehavioral developmental research. FAU - Novak, M F AU - Novak MF AD - Department of Psychology, University of Washington, Seattle 98195-1525, USA. FAU - Sackett, G P AU - Sackett GP LA - eng GR - HD02274/HD/NICHD NIH HHS/United States GR - RR00166/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Am J Primatol JT - American journal of primatology JID - 8108949 SB - IM MH - Animal Husbandry/*methods MH - Animals MH - Animals, Newborn MH - *Behavior, Animal MH - Female MH - Macaca nemestrina/*psychology MH - Male MH - *Social Behavior MH - Social Environment EDAT- 1997/01/01 00:00 MHDA- 2000/08/12 11:00 CRDT- 1997/01/01 00:00 PHST- 1997/01/01 00:00 [pubmed] PHST- 2000/08/12 11:00 [medline] PHST- 1997/01/01 00:00 [entrez] AID - 10.1002/(SICI)1098-2345(1997)41:2<141::AID-AJP6>3.0.CO;2-X [pii] AID - 10.1002/(SICI)1098-2345(1997)41:2<141::AID-AJP6>3.0.CO;2-X [doi] PST - ppublish SO - Am J Primatol. 1997;41(2):141-9. doi: 10.1002/(SICI)1098-2345(1997)41:2<141::AID-AJP6>3.0.CO;2-X. PMID- 30927392 OWN - NLM STAT- MEDLINE DCOM- 20190523 LR - 20190523 IS - 1210-7778 (Print) IS - 1210-7778 (Linking) VI - 27 IP - 1 DP - 2019 Mar TI - Examination of life quality, mental conditions and cognitive status of people over the age of 90: Results of a Hungarian local research. PG - 17-23 LID - 10.21101/cejph.a4753 [doi] AB - OBJECTIVES: The study presents the findings of a quantitative research conducted among people aged over 90, who live in a large town of Hungary, Debrecen. The aim of the research was to examine the lifestyle, attitudes, values, and physical and mental condition of old and long-lived people. We laid a special emphasis on the exploration of the life perspectives, mood and mental youth, and their interconnections. METHODS: The sociological questionnaire used for data collection (159 questions) was intended to inquire socio-demographic characteristics, dietary habits, health condition, physical activity, and identity features. Further examinations were conducted in order to measure the level of depression using the Geriatric Depression Scale (GDS) and mental condition using the Mini-Mental State Examination (MMSE). We managed to reach out to the elderly living in the town on the basis of family doctors' districts (N = 212). We dealt with a subsample of 115 people since we got answers for all questions from them. During data processing, we applied multivariate statistical methods, first of all linear regression analysis and cluster analysis. We examined the differences between clusters using variation analysis. RESULTS: According to our results, the extremely low educational level of the elderly belonging to the target group did not decrease their life perspectives, but it had a significant impact on the age when their illness begun. We revealed a connection between the mental condition and the level of depression. Better mental condition (higher MMSE) resulted in lower depression level (low GDS). One of our main finding is that the change in the level of depression (GDS) is 13.4% due to the change in the mental condition (MMSE). CONCLUSIONS: Physical and mental activity, personal autonomy, a wide range of activities, and avoiding isolation and solitude allow people to experience quality ageing; all these factors can be substantially influenced by the status acquired at a younger age. We believe that it is extremely important for the society to develop guarantees for active old age, which would ensure the optimal balance between the possibilities of physical and mental health, social participation and safety. FAU - Czibere, Ibolya AU - Czibere I AD - Department of Sociology and Social Policy, University of Debrecen, Debrecen, Hungary. FAU - Rácz, Andrea AU - Rácz A AD - Department of Social Work, University of Eotvos Lorand, Budapest, Hungary. FAU - Szilvási, Henrietta AU - Szilvási H AD - Gerontology Research Group, Institute of Internal Medicine, University of Debrecen, Debrecen, Hungary. FAU - Szikszai, Zita AU - Szikszai Z AD - Institute for Nuclear Research, Hungarian Academy of Science, Debrecen, Hungary. FAU - Imre, Sándor AU - Imre S AD - Gerontology Research Group, Institute of Internal Medicine, University of Debrecen, Debrecen, Hungary. LA - eng PT - Journal Article PL - Czech Republic TA - Cent Eur J Public Health JT - Central European journal of public health JID - 9417324 SB - IM MH - Aged MH - Aging/physiology/*psychology MH - Cognition/*physiology MH - Depression/*diagnosis/epidemiology MH - Geriatric Assessment MH - Health Status MH - Humans MH - Hungary/epidemiology MH - Life Style MH - *Mental Health MH - Psychiatric Status Rating Scales MH - Quality of Life/*psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - elderly people in the society OT - life quality of the elderly OT - long life OT - mental health of the elderly OT - super old EDAT- 2019/03/31 06:00 MHDA- 2019/05/24 06:00 CRDT- 2019/03/31 06:00 PHST- 2016/03/01 00:00 [received] PHST- 2019/03/31 06:00 [entrez] PHST- 2019/03/31 06:00 [pubmed] PHST- 2019/05/24 06:00 [medline] AID - 10.21101/cejph.a4753 [doi] PST - ppublish SO - Cent Eur J Public Health. 2019 Mar;27(1):17-23. doi: 10.21101/cejph.a4753. PMID- 25523351 OWN - NLM STAT- MEDLINE DCOM- 20151006 LR - 20240404 IS - 1545-1151 (Electronic) IS - 1545-1151 (Linking) VI - 11 DP - 2014 Dec 18 TI - NSAID-avoidance education in community pharmacies for patients at high risk for acute kidney injury, upstate New York, 2011. PG - E220 LID - 10.5888/pcd11.140298 [doi] LID - E220 AB - INTRODUCTION: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently associated with community-acquired acute kidney injury (AKI), a strong risk factor for development and progression of chronic kidney disease. Using access to prescription medication profiles, pharmacists can identify patients at high risk for NSAID-induced AKI. The primary objective of this analysis was to evaluate the effectiveness of a community pharmacy-based patient education program on patient knowledge of NSAID-associated renal safety concerns. METHODS: Patients receiving prescription medications for hypertension or diabetes mellitus were invited to participate in an educational program on the risks of NSAID use. A patient knowledge questionnaire (PKQ) consisting of 5 questions scored from 1 to 5 was completed before and after the intervention. Information was collected on age, race, sex, and frequency of NSAID use. RESULTS: A total of 152 participants (60% women) completed both the pre- and post-intervention questionnaire; average age was 54.6 (standard deviation [SD], 17.5). Mean pre-intervention PKQ score was 3.3 (SD, 1.4), and post-intervention score was 4.6 (SD, 0.9) (P = .002). Participants rated program usefulness (1 = not useful to 5 = extremely useful) as 4.2 (SD, 1.0). In addition, 48% reported current NSAID use and 67% reported that the program encouraged them to limit their use. CONCLUSION: NSAID use was common among patients at high risk for AKI. A brief educational intervention in a community pharmacy improved patient knowledge on NSAID-associated risks. Pharmacists practicing in the community can partner with primary care providers in the medical home model to educate patients at risk for AKI. FAU - Jang, Soo Min AU - Jang SM AD - Albany College of Pharmacy and Health Sciences, Albany, New York, and ANephRx Albany Nephrology Pharmacy Group, Albany, New York. Soo Min Jan is also a member of the New York State Chronic Kidney Disease Coalition, Albany, New York. FAU - Cerulli, Jennifer AU - Cerulli J AD - Albany College of Pharmacy and Health Sciences, Albany, New York. FAU - Grabe, Darren W AU - Grabe DW AD - Albany College of Pharmacy and Health Sciences, Albany, New York, and ANephRx Albany Nephrology Pharmacy Group, Albany, New York. Darren Grabe is also a member of the New York State Chronic Kidney Disease Coalition, Albany, New York. FAU - Fox, Chester AU - Fox C AD - University of Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York. Chester Fox is also a member of the New York State Chronic Kidney Disease Coalition, Albany, New York. FAU - Vassalotti, Joseph A AU - Vassalotti JA AD - Icahn School of Medicine at Mount Sinai, New York, New York. Joseph A. Vassalotti is also a member of the New York State Chronic Kidney Disease Coalition, Albany, New York. FAU - Prokopienko, Alexander J AU - Prokopienko AJ AD - Albany College of Pharmacy and Health Sciences, Albany, New York. FAU - Pai, Amy Barton AU - Pai AB AD - Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, Albany, NY 12208. E-mail: amy.bartonpai@acphs.edu. LA - eng PT - Comparative Study PT - Journal Article DEP - 20141218 PL - United States TA - Prev Chronic Dis JT - Preventing chronic disease JID - 101205018 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) SB - IM MH - Acute Kidney Injury/chemically induced/*prevention & control MH - Aged MH - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/therapeutic use MH - Cross-Sectional Studies MH - Diabetes Mellitus/drug therapy MH - Ethnicity/psychology/statistics & numerical data MH - Female MH - Glomerular Filtration Rate MH - *Health Knowledge, Attitudes, Practice MH - Health Literacy/statistics & numerical data MH - Health Promotion MH - Humans MH - Hypertension/drug therapy MH - Male MH - Middle Aged MH - New York MH - Nutrition Surveys MH - Outcome Assessment, Health Care MH - Patient Education as Topic/*methods MH - *Pharmacies/statistics & numerical data MH - Practice Guidelines as Topic MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC4273546 EDAT- 2014/12/20 06:00 MHDA- 2015/10/07 06:00 PMCR- 2014/01/01 CRDT- 2014/12/20 06:00 PHST- 2014/12/20 06:00 [entrez] PHST- 2014/12/20 06:00 [pubmed] PHST- 2015/10/07 06:00 [medline] PHST- 2014/01/01 00:00 [pmc-release] AID - E220 [pii] AID - 14_0298 [pii] AID - 10.5888/pcd11.140298 [doi] PST - epublish SO - Prev Chronic Dis. 2014 Dec 18;11:E220. doi: 10.5888/pcd11.140298. PMID- 32629742 OWN - NLM STAT- MEDLINE DCOM- 20200717 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 99 IP - 27 DP - 2020 Jul 2 TI - The diagnosis of intramural esophageal squamous cell carcinoma without mucosal invasion using endoscopic ultrasound-guided fine needle aspiration biopsy: A case report. PG - e21099 LID - 10.1097/MD.0000000000021099 [doi] LID - e21099 AB - RATIONALE: Intramural esophageal squamous cell carcinoma (ESCC) without mucosal invasion is extremely rare. Endoscopic mucosal biopsy results are often negative, making diagnosis difficult. In these cases, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy is a useful diagnostic method. PATIENT CONCERNS: A 78-year-old female was admitted to hospital due to dysphagia, and gastroscopy showed a concentric narrowing of the esophageal lumen with a smooth and undamaged esophageal mucosa. DIAGNOSES: Endoscopic ultrasound (EUS) revealed that the esophageal mucosa was thickened with a low echo, and the layers of the esophageal wall could not be clearly distinguished. Cytologic and pathologic diagnoses were obtained through EUS-FNA, which suggested ESCC. INTERVENTIONS: According to the pathologic diagnosis obtained by EUS-FNA, surgery or radiotherapy were recommended for this patient. Eventually, this patient elected to seek treatment at another medical institution. OUTCOMES: This type of disease cannot be diagnosed according to gastroscopic biopsy alone, and the diagnosis was eventually confirmed through EUS-FNA. LESSONS: When an imaging examination suggests a possible malignant lesion of the oesophagus, EUS-FNA may be considered if the surface mucosa contains no endoscopic damage. EUS-FNA has high diagnostic value with high sensitivity, minimal invasiveness, and high safety. FAU - Pan, Hanghai AU - Pan H AUID- ORCID: 0000-0002-7366-8269 AD - Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College. FAU - Zhou, XinXin AU - Zhou X AD - Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province, China. FAU - Zhao, Fei AU - Zhao F AD - Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College. FAU - Lou, Guochun AU - Lou G AD - Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Aged MH - Deglutition Disorders/diagnosis/etiology MH - Endoscopic Ultrasound-Guided Fine Needle Aspiration/*methods MH - Esophageal Neoplasms/*pathology MH - Esophageal Squamous Cell Carcinoma/*diagnostic imaging/*pathology MH - Female MH - Gastroscopy/methods MH - Hospitalization MH - Humans MH - Mucous Membrane/pathology MH - Patient Dropouts/psychology MH - Radiotherapy/standards MH - Surgical Procedures, Operative/standards PMC - PMC7337455 COIS- The authors have no conflicts of interest to disclose. EDAT- 2020/07/08 06:00 MHDA- 2020/07/18 06:00 PMCR- 2020/07/02 CRDT- 2020/07/08 06:00 PHST- 2020/07/08 06:00 [entrez] PHST- 2020/07/08 06:00 [pubmed] PHST- 2020/07/18 06:00 [medline] PHST- 2020/07/02 00:00 [pmc-release] AID - 00005792-202007020-00121 [pii] AID - MD-D-19-08731 [pii] AID - 10.1097/MD.0000000000021099 [doi] PST - ppublish SO - Medicine (Baltimore). 2020 Jul 2;99(27):e21099. doi: 10.1097/MD.0000000000021099. PMID- 24902503 OWN - NLM STAT- MEDLINE DCOM- 20150202 LR - 20140606 IS - 1878-6847 (Electronic) IS - 0924-6479 (Linking) VI - 26 IP - 2 DP - 2014 TI - Awareness about and views of parents on the off-label drug use in children. PG - 61-70 LID - 10.3233/JRS-140613 [doi] AB - BACKGROUND: Off-label use of drugs is widely prevalent in children mainly due to a limited data generated in children during drug development process. Parents play a critical role in giving consent for their child to participate in clinical trials. Very few studies have assessed the opinion of the parents regarding such use and permitting their child to participate in clinical trials. OBJECTIVE: In view of lack of information about the awareness among parents regarding both off-label drug use in children as well as about allowing their child to participate in clinical research especially from a developing country, this study was conducted. METHODS: Adults accompanying patients in a tertiary care hospital were administered a validated, structured questionnaire following written informed consent. The questionnaire consisted of 18 items broadly divided into 5 themes - parental views on safety and labelled use of drugs in children, awareness of off-label drug use in children, communication from healthcare worker about it, parental views on off-label drug use in children and willingness to allow their child to participate in a clinical trial. Chi-square or Fisher's exact probability test and McNemar's test were used for analysis. RESULTS: Initially, a majority of the participants felt that the drugs used in children in hospital (89.5%) and prescribed by a family physician (80.3%) were either safe or extremely safe while after the concept of off-label drug use is explained, a significant reduction in the proportion (59.3% in hospital and 59.8% by family physician) of parents felt the same. Only 30% parents were aware of off-label drug use in children. Ninety-three percent of the parents wanted to be informed whenever a doctor prescribes a drug in an off-label manner and a similar percentage felt the off-label drug use would increase the side-effects. Seventy three percent parents felt the off-label drug use is illegal and 57% would ask for change to a labelled drug in case of such prescription in their children. A majority of the parents would allow their child to participate in case of a life-threatening condition (59.8%) or in case of a chronic illness (51.3%) but significantly less when their child is healthy. CONCLUSION: The present study has found a low level of awareness regarding the concept of off-label drug use in children amongst the public. Our study also shows that parents expect that the doctor explains the fact to them, although they appear to vest a large amount of trust in the doctor's judgement in doing the best for their sick child. Parents were more willing to allow their child's participation in clinical research if their child was seriously ill than if healthy, indicating the need to educate the society about the need for clinical research so that they could take more informed decisions. FAU - Bang, V AU - Bang V AD - Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India. FAU - Mallad, A AU - Mallad A AD - Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India. FAU - Kannan, S AU - Kannan S AD - Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India. FAU - Bavdekar, S B AU - Bavdekar SB AD - Department of Pediatrics, TNMC and BYL Nair Hospital, Mumbai, India. FAU - Gogtay, N J AU - Gogtay NJ AD - Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India. FAU - Thatte, U M AU - Thatte UM AD - Department of Clinical Pharmacology, Seth GS Medical College & KEM Hospital, Parel, Mumbai, India. LA - eng PT - Journal Article PL - United States TA - Int J Risk Saf Med JT - The International journal of risk & safety in medicine JID - 9100907 SB - IM MH - Adolescent MH - Adult MH - Clinical Trials as Topic/*psychology MH - Communication MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Healthy Volunteers/*psychology MH - Humans MH - Informed Consent MH - Male MH - Middle Aged MH - *Off-Label Use MH - Parents/*psychology MH - Professional-Family Relations MH - Tertiary Care Centers MH - Young Adult OTO - NOTNLM OT - Awareness OT - children OT - clinical trials OT - off-label drug use OT - parents EDAT- 2014/06/07 06:00 MHDA- 2015/02/03 06:00 CRDT- 2014/06/07 06:00 PHST- 2014/06/07 06:00 [entrez] PHST- 2014/06/07 06:00 [pubmed] PHST- 2015/02/03 06:00 [medline] AID - 773W16218T5N3844 [pii] AID - 10.3233/JRS-140613 [doi] PST - ppublish SO - Int J Risk Saf Med. 2014;26(2):61-70. doi: 10.3233/JRS-140613. PMID- 22317184 OWN - NLM STAT- MEDLINE DCOM- 20141210 LR - 20191210 IS - 1875-9270 (Electronic) IS - 1051-9815 (Linking) VI - 41 Suppl 1 DP - 2012 TI - Whistleblowers: an essential resource for the sustainable prevention of risks in sociotechnical systems. PG - 3051-61 LID - 10.3233/WOR-2012-0563-3051 [doi] AB - Our world of industry and technology has, over the years, has seen undeniable successes in terms of safety and reliability. But major catastrophes and dramatic accidents continue, even today, to cause major human and material losses and to threaten the environment with pollution on a massive scale. Could these disasters and these accidents have been foreseen and avoided? Would it have been possible to anticipate their occurrence by detecting signals of potential hazards? It is unsettling to notice, through retrospective analysis of such events, that warnings had been issued long before the catastrophe or accident took place. This raises several questions, which we will attempt to address in this paper. Why are whistleblowers often not listened to, threatened, or simply ignored? Why are their warnings viewed as "bad omens" instead of essential resources to ensure safety? Do whistleblowers stand idly by, or do they implement individual and collective strategies to make themselves heard? Which managerial and organizational conditions are conducive to developing empowerment in whistleblowers? Based on four case studies, we attempt to address these questions, and offer a first level of analysis and explanation by proposing and defining two new concepts: operative resilience and strategic resilience. FAU - Benchekroun, Tahar Hakim AU - Benchekroun TH AD - Conservatoire National des Arts et Métiers, Centre de Recherche sur le Travail et Développement (CRTD), 41 rue Gay-Lussac, 75005 Paris, France. tahar-hakim.benchekroun@cnam.fr FAU - Pierlot, Sandrine AU - Pierlot S LA - eng PT - Journal Article PL - United States TA - Work JT - Work (Reading, Mass.) JID - 9204382 SB - IM MH - *Accident Prevention MH - Disasters/*prevention & control MH - Extreme Heat MH - Humans MH - Nuclear Power Plants MH - Organizational Culture MH - Power, Psychological MH - Resilience, Psychological MH - Seveso Accidental Release MH - Spacecraft MH - *Whistleblowing/psychology EDAT- 2012/02/10 06:00 MHDA- 2014/12/15 06:00 CRDT- 2012/02/10 06:00 PHST- 2012/02/10 06:00 [entrez] PHST- 2012/02/10 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - 8152U735668285W0 [pii] AID - 10.3233/WOR-2012-0563-3051 [doi] PST - ppublish SO - Work. 2012;41 Suppl 1:3051-61. doi: 10.3233/WOR-2012-0563-3051. PMID- 11117767 OWN - NLM STAT- MEDLINE DCOM- 20001222 LR - 20220310 IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 107 IP - 11 DP - 2000 Nov TI - A randomised comparison and economic evaluation of laparoscopic-assisted hysterectomy and abdominal hysterectomy. PG - 1386-91 AB - OBJECTIVES: To determine the safety, cost effectiveness and effect on quality of life of laparoscopic-assisted vaginal hysterectomy (LAVH) compared with total abdominal hysterectomy (TAH) in the management of benign gynaecological disease. DESIGN: Randomised controlled trial and economic evaluation. SETTING: Three hospitals in the West of Scotland. PARTICIPANTS: Two hundred women scheduled for an abdominal hysterectomy for benign gynaecological disease. MAIN OUTCOME MEASURES: Conversion rate of LAVH to TAH, complication rates, NHS resource use and costs, quality of life using EuroQol 5 D visual analogue scale, and achievement of milestones. RESULTS: The overall incidence of operative complications was 14% in the TAH group and 8% in the LAVH group, with an 8% conversion rate. Length of operation was significantly greater in the women having LAVH at 81 +/- 30 min vs 47 +/- 16 min (P < 0.001). There was no difference in analgesic requirements between the groups although there was a significantly shorter hospital stay for those having LAVH. The rate of post-surgery recovery, satisfaction with operation and quality of life at four weeks post-operative were similar in the two groups of women. LAVH was significantly more expensive than TAH and remained more expensive for all but the most extreme scenario. CONCLUSIONS: This study demonstrates that despite the decreased length of hospital stay, LAVH is more expensive than TAH. In addition, recovery following operation and patient satisfaction were not affected by the route chosen. It is unlikely that LAVH represents an efficient use of NHS resources. FAU - Lumsden, M A AU - Lumsden MA AD - Western Infirmary, Southern General Hospital, Glasgow. FAU - Twaddle, S AU - Twaddle S FAU - Hawthorn, R AU - Hawthorn R FAU - Traynor, I AU - Traynor I FAU - Gilmore, D AU - Gilmore D FAU - Davis, J AU - Davis J FAU - Deeny, M AU - Deeny M FAU - Cameron, I T AU - Cameron IT FAU - Walker, J J AU - Walker JJ LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Adult MH - Cost-Benefit Analysis MH - Female MH - Genital Diseases, Female/*surgery MH - Humans MH - Hysterectomy/adverse effects/*economics/methods MH - Hysterectomy, Vaginal/adverse effects/economics/methods MH - Laparoscopy/*methods MH - Length of Stay MH - Patient Satisfaction MH - Quality of Life/psychology MH - Treatment Outcome EDAT- 2000/12/16 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/12/16 11:00 PHST- 2000/12/16 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/12/16 11:00 [entrez] AID - 10.1111/j.1471-0528.2000.tb11653.x [doi] PST - ppublish SO - BJOG. 2000 Nov;107(11):1386-91. doi: 10.1111/j.1471-0528.2000.tb11653.x. PMID- 28242468 OWN - NLM STAT- MEDLINE DCOM- 20180226 LR - 20181001 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 174 DP - 2017 May 15 TI - Habituation of the cold shock response is inhibited by repeated anxiety: Implications for safety behaviour on accidental cold water immersions. PG - 10-17 LID - S0031-9384(16)31004-6 [pii] LID - 10.1016/j.physbeh.2017.02.026 [doi] AB - INTRODUCTION: Accidental cold-water immersion (CWI) triggers the life-threatening cold shock response (CSR) which is a precursor to sudden death on immersion. One practical means of reducing the CSR is to induce an habituation by undergoing repeated short CWIs. Habituation of the CSR is known to be partially reversed by the concomitant experience of acute anxiety, raising the possibility that repeated anxiety could prevent CSR habituation; we tested this hypothesis. METHOD: Sixteen participants (12 male, 4 female) completed seven, seven-minute immersions in to cold water (15°C). Immersion one acted as a control (CON1). During immersions two to five, which would ordinarily induce an habituation, anxiety levels were repeatedly increased (CWI-ANX(rep)) by deception and a demanding mathematical task. Immersions six and seven were counter-balanced with another high anxiety condition (CWI-ANX(rep)) or a further control (CON2). Anxiety (20cm visual analogue scale) and cardiorespiratory responses (cardiac frequency [f(c)], respiratory frequency [f(R)], tidal volume [V(T)], minute ventilation [V̇(E)]) were measured. Comparisons were made between experimental immersions (CON1, final CWI-ANX(rep), CON2), across habituation immersions and with data from a previous study. RESULTS: Anxiety levels were sustained at a similar level throughout the experimental and habituation immersions (mean [SD] CON1: 7.0 [4.0] cm; CON2: 5.8 [5.2] cm cf CWI-ANX(rep): 7.3 [5.5] cm; p>0.05). This culminated in failure of the CSR to habituate even when anxiety levels were not manipulated (i.e. CON2). These data were different (p<0.05) to previous studies where anxiety levels were allowed to fall across habituation immersions and the CSR consequently habituated. DISCUSSION: Repeated anxiety prevented CSR habituation. A protective strategy that includes inducing habituation for those at risk should include techniques to lower anxiety associated with the immersion event or habituation may not be beneficial in the emergency scenario. CI - Copyright © 2017 Elsevier Inc. All rights reserved. FAU - Barwood, Martin J AU - Barwood MJ AD - Leeds Trinity University, Department of Sport, Health and Nutrition, Brownberrie Lane, Horsforth, Leeds LS18 5HD, UK. Electronic address: M.Barwood@leedstrinity.ac.uk. FAU - Corbett, Jo AU - Corbett J AD - University of Portsmouth, Extreme Environments Laboratory, Department of Sport and Exercise Science, Spinnaker Building, Cambridge Road, Portsmouth, UK. Electronic address: Jo.corbett@port.ac.uk. FAU - Tipton, Mike AU - Tipton M AD - University of Portsmouth, Extreme Environments Laboratory, Department of Sport and Exercise Science, Spinnaker Building, Cambridge Road, Portsmouth, UK. Electronic address: michael.tipton@port.ac.uk. FAU - Wagstaff, Christopher AU - Wagstaff C AD - University of Portsmouth, Department of Sport and Exercise Science, Spinnaker Building, Cambridge Road, Portsmouth, UK. Electronic address: chris.wagstaff@port.ac.uk. FAU - Massey, Heather AU - Massey H AD - University of Portsmouth, Extreme Environments Laboratory, Department of Sport and Exercise Science, Spinnaker Building, Cambridge Road, Portsmouth, UK. Electronic address: heather.massey@port.ac.uk. LA - eng PT - Journal Article DEP - 20170224 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 059QF0KO0R (Water) SB - IM MH - Anxiety/etiology/*psychology MH - Cold Temperature/*adverse effects MH - Cold-Shock Response/*physiology MH - Female MH - Habituation, Psychophysiologic/*physiology MH - Heart Rate/physiology MH - Humans MH - Immersion MH - Male MH - Mathematics MH - Respiration MH - Time Factors MH - Visual Analog Scale MH - *Water MH - Young Adult OTO - NOTNLM OT - Cold shock OT - Cold water OT - Drowning OT - Perception EDAT- 2017/03/01 06:00 MHDA- 2018/02/27 06:00 CRDT- 2017/03/01 06:00 PHST- 2016/11/05 00:00 [received] PHST- 2017/02/03 00:00 [revised] PHST- 2017/02/22 00:00 [accepted] PHST- 2017/03/01 06:00 [pubmed] PHST- 2018/02/27 06:00 [medline] PHST- 2017/03/01 06:00 [entrez] AID - S0031-9384(16)31004-6 [pii] AID - 10.1016/j.physbeh.2017.02.026 [doi] PST - ppublish SO - Physiol Behav. 2017 May 15;174:10-17. doi: 10.1016/j.physbeh.2017.02.026. Epub 2017 Feb 24. PMID- 21320300 OWN - NLM STAT- MEDLINE DCOM- 20110628 LR - 20211020 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 12 DP - 2011 Feb 14 TI - Efficacy and safety of a multifactor intervention to improve therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): protocol for the ICEPOC study. PG - 40 LID - 10.1186/1745-6215-12-40 [doi] AB - BACKGROUND: Low therapeutic adherence to medication is very common. Clinical effectiveness is related to dose rate and route of administration and so poor therapeutic adherence can reduce the clinical benefit of treatment. The therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is extremely poor according to most studies. The research about COPD adherence has mainly focussed on quantifying its effect, and few studies have researched factors that affect non-adherence. Our study will evaluate the effectiveness of a multifactor intervention to improve the therapeutic adherence of COPD patients. METHODS/DESIGN: A randomized controlled clinical trial with 140 COPD diagnosed patients selected by a non-probabilistic method of sampling. Subjects will be randomly allocated into two groups, using the block randomization technique. Every patient in each group will be visited four times during the year of the study. INTERVENTION: Motivational aspects related to adherence (beliefs and behaviour): group and individual interviews; cognitive aspects: information about illness; skills: inhaled technique training. Reinforcement of the cognitive-emotional aspects and inhaled technique training will be carried out in all visits of the intervention group. DISCUSSION: Adherence to a prescribed treatment involves a behavioural change. Cognitive, emotional and motivational aspects influence this change and so we consider the best intervention procedure to improve adherence would be a cognitive and emotional strategy which could be applied in daily clinical practice. Our hypothesis is that the application of a multifactor intervention (COPD information, dose reminders and reinforcing audiovisual material, motivational aspects and inhalation technique training) to COPD patients taking inhaled treatment will give a 25% increase in the number of patients showing therapeutic adherence in this group compared to the control group.We will evaluate the effectiveness of this multifactor intervention on patient adherence to inhaled drugs considering that it will be right and feasible to the clinical practice context. TRIAL REGISTRATION: Current Controlled Trials ISRCTN18841601. FAU - Barnestein-Fonseca, Pilar AU - Barnestein-Fonseca P AD - Family and Community Medicine Teaching Unit of Malaga, Distrito Sanitario Málaga, Málaga, Spain. mariap.barnestein.exts@juntadeandalucia.es FAU - Leiva-Fernández, José AU - Leiva-Fernández J FAU - Vidal-España, Francisca AU - Vidal-España F FAU - García-Ruiz, Antonio AU - García-Ruiz A FAU - Prados-Torres, Daniel AU - Prados-Torres D FAU - Leiva-Fernández, Francisca AU - Leiva-Fernández F LA - eng SI - ISRCTN/ISRCTN18841601 PT - Journal Article PT - Randomized Controlled Trial DEP - 20110214 PL - England TA - Trials JT - Trials JID - 101263253 RN - 0 (Bronchodilator Agents) SB - IM MH - Administration, Inhalation MH - Bronchodilator Agents/*administration & dosage MH - Cognition MH - Emotions MH - Health Behavior MH - *Health Knowledge, Attitudes, Practice MH - Humans MH - *Medication Adherence MH - Motivation MH - Nebulizers and Vaporizers MH - *Patient Education as Topic MH - Pulmonary Disease, Chronic Obstructive/*drug therapy MH - Reinforcement, Psychology MH - *Research Design MH - Spain MH - Treatment Outcome PMC - PMC3049740 EDAT- 2011/02/16 06:00 MHDA- 2011/06/29 06:00 PMCR- 2011/02/14 CRDT- 2011/02/16 06:00 PHST- 2010/07/09 00:00 [received] PHST- 2011/02/14 00:00 [accepted] PHST- 2011/02/16 06:00 [entrez] PHST- 2011/02/16 06:00 [pubmed] PHST- 2011/06/29 06:00 [medline] PHST- 2011/02/14 00:00 [pmc-release] AID - 1745-6215-12-40 [pii] AID - 10.1186/1745-6215-12-40 [doi] PST - epublish SO - Trials. 2011 Feb 14;12:40. doi: 10.1186/1745-6215-12-40. PMID- 29138934 OWN - NLM STAT- MEDLINE DCOM- 20171214 LR - 20181113 IS - 1432-1904 (Electronic) IS - 0028-1042 (Linking) VI - 104 IP - 11-12 DP - 2017 Nov 14 TI - Habitat quality affects stress responses and survival in a bird wintering under extremely low ambient temperatures. PG - 99 LID - 10.1007/s00114-017-1519-8 [doi] AB - Animals normally respond to stressful environmental stimuli by releasing glucocorticoid hormones. We investigated whether baseline corticosterone (CORT), handling-induced corticosterone concentration(s), and body condition indices of members of willow tit (Poecile montanus) groups differed while wintering in old growth forests and managed young forests in mild weather conditions and during cold spells. Willow tits spend the winter season in non-kin groups in which dominant individuals typically claim their priority to access resources, while subordinate individuals may experience greater levels of stress and higher mortality, especially during cold spells. We captured birds to measure baseline CORT and levels of handling-induced CORT secretion after 20 min of capture. Willow tits in the young forests had higher baseline CORT and a smaller increase in CORT in response to capture than individuals in the old forests. Baseline CORT was higher in females and juvenile birds compared to adult males, whereas handling-induced CORT secretion did not differ between birds of different ages. During cold spells, baseline CORT of willow tits increased and handling-induced CORT secretion decreased, especially in birds in young forests. Willow tits' survival was higher in the old forests, with dominant individuals surviving better than subordinates. Our results show that changes in CORT secretion reflect responses to habitat quality and climate harshness, indicating young managed coniferous forests as a suboptimal habitat for the willow tit. FAU - Cīrule, Dina AU - Cīrule D AD - Animal Health and Environment BIOR, Institute of Food Safety, Rīga, Latvia. FAU - Krama, Tatjana AU - Krama T AD - Department of Plant Protection, Institute of Agricultural and Environmental Sciences, Estonian University of Life Science, Tartu, Estonia. AD - Department of Biotechnology, Daugavpils University, Daugavpils, Latvia. FAU - Krams, Ronalds AU - Krams R AD - Department of Biotechnology, Daugavpils University, Daugavpils, Latvia. FAU - Elferts, Didzis AU - Elferts D AD - Department of Botany and Ecology, Faculty of Biology, University of Latvia, Rīga, Latvia. AD - Latvian State Forest Research Institute "Silava", Salaspils, Latvia. FAU - Kaasik, Ants AU - Kaasik A AD - Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia. FAU - Rantala, Markus J AU - Rantala MJ AD - Department of Biology, Turku Brain and Mind Centre, University of Turku, Turku, Finland. FAU - Mierauskas, Pranas AU - Mierauskas P AD - Department of Environment Policy, Mykolas Romeris University, Vilnius, Lithuania. FAU - Luoto, Severi AU - Luoto S AD - English, Drama and Writing Studies, and School of Psychology, University of Auckland, Auckland, 1010, New Zealand. FAU - Krams, Indrikis A AU - Krams IA AUID- ORCID: 0000-0001-7150-4108 AD - Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia. indrikis.krams@ut.ee. AD - Department of Zoology and Animal Ecology, Faculty of Biology, University of Latvia, Rīga, Latvia. indrikis.krams@ut.ee. LA - eng GR - PUT1223/Eesti Teadusagentuur/ GR - 290/2012/Latvijas Zinātnes Padome/ GR - 07.2100/Latvijas Zinātnes Padome/ PT - Journal Article DEP - 20171114 PL - Germany TA - Naturwissenschaften JT - Die Naturwissenschaften JID - 0400767 RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - *Cold Temperature MH - Corticosterone/blood MH - *Ecosystem MH - Female MH - Male MH - Seasons MH - Stress, Physiological/*physiology MH - Survival Analysis OTO - NOTNLM OT - Corticosterone OT - Dominance hierarchy OT - Habitat quality OT - Stress OT - Willow tits OT - Winter survival EDAT- 2017/11/16 06:00 MHDA- 2017/12/15 06:00 CRDT- 2017/11/16 06:00 PHST- 2017/07/20 00:00 [received] PHST- 2017/10/17 00:00 [accepted] PHST- 2017/10/15 00:00 [revised] PHST- 2017/11/16 06:00 [entrez] PHST- 2017/11/16 06:00 [pubmed] PHST- 2017/12/15 06:00 [medline] AID - 10.1007/s00114-017-1519-8 [pii] AID - 10.1007/s00114-017-1519-8 [doi] PST - epublish SO - Naturwissenschaften. 2017 Nov 14;104(11-12):99. doi: 10.1007/s00114-017-1519-8. PMID- 25053606 OWN - NLM STAT- MEDLINE DCOM- 20150411 LR - 20151119 IS - 1541-3772 (Electronic) IS - 1048-2911 (Linking) VI - 24 IP - 1 DP - 2014 TI - Risks endemic to long-haul trucking in North America: strategies to protect and promote driver well-being. PG - 57-81 LID - 10.2190/NS.24.1.c [doi] AB - Long-haul truck drivers in North America function in a work context marked by excess physical and psychological workload, erratic schedules, disrupted sleep patterns, extreme time pressures, and these factors' far-reaching consequences. These work-induced stressors are connected with excess risk for cardiometabolic disease, certain cancers, and musculoskeletal and sleep disorders, as well as highway crashes, which in turn exert enormous financial burdens on trucking and warehousing companies, governments and healthcare systems, along with working people within the sector. This article: 1) delineates the unique work environment of long-haul truckers, describing their work characteristics and duties; (2) discusses the health hazards of long-haul trucking that impact drivers, the general population, and trucking enterprises, examining how this work context induces, sustains, and exacerbates these hazards; and (3) proposes comprehensive, multi-level strategies with potential to protect and promote the health, safety, and well-being of truckers, while reducing adverse consequences for companies and highway safety. FAU - Apostolopoulos, Yorghos AU - Apostolopoulos Y AD - Department of Public Health Education of the School of Health and Human Sciences, University of North Carolina Greensboro. FAU - Lemke, Michael AU - Lemke M AD - Community Psychology doctoral program, Wichita State University. FAU - Sönmez, Sevil AU - Sönmez S AD - Department of Marketing, Entrepreneurship, Hospitality, and Tourism, Bryan School of Business and Economics of the University of North Carolina Greensboro. LA - eng PT - Journal Article PL - United States TA - New Solut JT - New solutions : a journal of environmental and occupational health policy : NS JID - 9100937 RN - 0 (Air Pollutants, Occupational) SB - IM MH - Adult MH - Air Pollutants, Occupational/*adverse effects MH - *Automobile Driving MH - Cardiovascular Diseases/epidemiology MH - Causality MH - Fatigue/epidemiology MH - Female MH - *Health Status Indicators MH - Humans MH - Lung Diseases/epidemiology MH - Male MH - Mental Disorders/epidemiology MH - Middle Aged MH - *Motor Vehicles MH - Musculoskeletal Diseases/epidemiology MH - Neoplasms/epidemiology MH - North America/epidemiology MH - Obesity/epidemiology MH - Occupational Diseases/*chemically induced/epidemiology/*prevention & control MH - Sleep Wake Disorders/epidemiology OTO - NOTNLM OT - excess driver morbidity OT - highway safety OT - long-haul truckers OT - prevention and protection strategies OT - work environment EDAT- 2014/07/24 06:00 MHDA- 2015/04/12 06:00 CRDT- 2014/07/24 06:00 PHST- 2014/07/24 06:00 [entrez] PHST- 2014/07/24 06:00 [pubmed] PHST- 2015/04/12 06:00 [medline] AID - X431U7355NR44246 [pii] AID - 10.2190/NS.24.1.c [doi] PST - ppublish SO - New Solut. 2014;24(1):57-81. doi: 10.2190/NS.24.1.c. PMID- 11928211 OWN - NLM STAT- MEDLINE DCOM- 20021018 LR - 20101118 IS - 0361-073X (Print) IS - 0361-073X (Linking) VI - 28 IP - 1 DP - 2002 Jan-Mar TI - Work ability, age and its perception, and other related concerns of Ukraine health care workers. PG - 59-71 AB - A sample of 250 health care workers aged 18 to 68 (mean = 32.5 years) completed the Survey of Health Care Professionals. Self-ratings of their social skills, mental capacity, and physical capability corresponded to their ratings of work demands. Physical tiredness and tension were rated higher than mental tiredness. Worker age did not affect self-ratings of work performance, but physical and mental tiredness increased with increases in the age that one felt. The younger participants felt compared to their calendar ages, the better the level of current work ability they reported. The main concerns of workers were connected with off-the-job factors, most likely caused by the economic crisis and unfavorable ecological conditions in Ukraine. More than half of the participants were quite a bit or extremely concerned with changes in the cost of living, water quality, food safety, and radiation. The variable most closely related to these concerns is the discrepancy between calendar age and how old one feels. Coping strategies of workers can be related to sleeping, entertainment, and other off-the-job activities. These behaviors are related to the discrepancy between calendar age and how old one looks and feels, as well as felt age. FAU - Bobko, Natalia A AU - Bobko NA AD - Institute for Occupational Health, Saksagansky Street, 75, Kiev-33, 01033, Ukraine. Natalia@ioh.freenet.kiev.ua FAU - Barishpolets, Alexey T AU - Barishpolets AT LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Exp Aging Res JT - Experimental aging research JID - 7603335 SB - IM MH - Adult MH - Aged MH - Burnout, Professional MH - Economics MH - Female MH - Humans MH - Job Satisfaction MH - Leisure Activities/classification/psychology MH - Male MH - Middle Aged MH - Nurses/*psychology MH - Personal Satisfaction MH - Physicians/*psychology MH - Professional Competence MH - *Self Concept MH - Self-Assessment EDAT- 2002/04/04 10:00 MHDA- 2002/10/19 04:00 CRDT- 2002/04/04 10:00 PHST- 2002/04/04 10:00 [pubmed] PHST- 2002/10/19 04:00 [medline] PHST- 2002/04/04 10:00 [entrez] AID - 10.1080/036107302753365559 [doi] PST - ppublish SO - Exp Aging Res. 2002 Jan-Mar;28(1):59-71. doi: 10.1080/036107302753365559. PMID- 33054614 OWN - NLM STAT- MEDLINE DCOM- 20210222 LR - 20210222 IS - 1545-0813 (Electronic) IS - 1059-924X (Linking) VI - 25 IP - 4 DP - 2020 Oct TI - Horticulture in Queensland Australia, COVID-19 Response. It Hasn't All Been Bad on Reflection. PG - 402-408 LID - 10.1080/1059924X.2020.1815620 [doi] AB - Australia and with that Queensland have been extremely fortunate with the impact of COVID-19. Queensland has only had 1,067 cases as of June 30, 2020, of which 78% have been overseas acquired. Australia and Queensland acted early to address COVID-19 by putting in place a range of strategies including travel bans (international and domestic), isolation measures, testing regimes, advice to business, economic support, and research funding. Agriculture was designated an essential business and as such has continued operating throughout the pandemic. They have however had to develop and implement COVID plans to keep workers safe. To help agricultural business establish plans information was developed by Safe Work Australia, National Farmers Federation and the Queensland Department of Workplace Health and Safety. Workforce issues were identified early, particularly seasonal workers (those who travel from their usual place of residence to another place to work). The Queensland Government enacted a directive about how seasonal workers were to be managed and also developed a guide specifically for horticulture to help manage their COVID-19 response. We provide two case studies demonstrating how agriculture has responded to COVID-19. Agriculture has successfully, in Queensland, adapted quickly to the changing work conditions due to COVID-19. This is due to all levels of government coming together with industry to find solutions. Some changes have had wider benefits such as improved sanitation, better communication and a greater recognition of seasonal worker needs. Being prepared and resilient has enabled agriculture to alleviate the impact on their businesses ensuring the health of all. FAU - Franklin, Richard C AU - Franklin RC AUID- ORCID: 0000-0003-1864-4552 AD - Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University , Townsville, Australia. FAU - O'Sullivan, Fiona AU - O'Sullivan F AD - Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University , Townsville, Australia. LA - eng PT - Journal Article DEP - 20201015 PL - England TA - J Agromedicine JT - Journal of agromedicine JID - 9421530 SB - IM MH - COVID-19/epidemiology/*psychology MH - Farmers/statistics & numerical data MH - *Horticulture/statistics & numerical data MH - Humans MH - *Occupational Health MH - Queensland/epidemiology MH - Resilience, Psychological OTO - NOTNLM OT - COVID-19 OT - Queensland OT - WHS OT - horticulture OT - resilience OT - safety EDAT- 2020/10/16 06:00 MHDA- 2021/02/23 06:00 CRDT- 2020/10/15 17:08 PHST- 2020/10/16 06:00 [pubmed] PHST- 2021/02/23 06:00 [medline] PHST- 2020/10/15 17:08 [entrez] AID - 10.1080/1059924X.2020.1815620 [doi] PST - ppublish SO - J Agromedicine. 2020 Oct;25(4):402-408. doi: 10.1080/1059924X.2020.1815620. Epub 2020 Oct 15. PMID- 24520910 OWN - NLM STAT- MEDLINE DCOM- 20141009 LR - 20211021 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 14 DP - 2014 Feb 12 TI - German adaptation of the Resources for Enhancing Alzheimer's Caregiver Health II: study protocol of a single-centred, randomised controlled trial. PG - 21 LID - 10.1186/1471-2318-14-21 [doi] AB - BACKGROUND: Caring for a family member with dementia is extremely stressful, and contributes to psychiatric and physical illness among caregivers. Therefore, a comprehensive programme called Resources for Enhancing Alzheimer's Caregiver Health II (REACH II) was developed in the United States to enhance the health of Alzheimer's caregivers. REACH II causes a clear reduction of the stress and burdens faced by informal caregivers at home. The aim of this protocol is to adapt, apply, and evaluate this proven intervention programme in a German-speaking area for the first time. This newly adapted intervention is called Deutsche Adaption der Resources for Enhancing Alzheimer's Caregiver Health (DeREACH). METHODS: A total of 138 informal caregivers at home are recruited in a single-centred, randomised controlled trial. The intervention (DeREACH) consists of nine home visits and three telephone contacts over six months, all of which focus on safety, psychological well-being and self-care, social support, problem behaviour and preventive health-related behaviours. A complex intervention assessment on effectiveness will be adopted when the primary outcome - namely, the reduction of caregiver burden - and other secondary outcomes, including changes with regard to anxiety and depression, somatisation, health-related quality of life, and perceived social support, are measured at baseline, as well as immediately and three months after the intervention. The change from baseline to post-intervention assessment with regard to the primary outcome will be compared between treatment and control group using t-tests for independent samples. DISCUSSION: It is anticipated that this study will show that DeREACH effectively reduces caregiver burden and therefore works under the conditions of a local German health-care system. If successful, this programme will provide an effective intervention programme in the German-speaking area to identify and develop the personal capabilities of informal caregivers to cope with the burdens of caring for people with dementia. FAU - Heinrich, Stephanie AU - Heinrich S AD - Clinic and Policlinic for Psychiatry and Psychotherapy, Leipzig University, Semmelweisstr, 10, 04103 Leipzig, Germany. Stephanie.Heinrich@medizin.uni-leipzig.de. FAU - Berwig, Martin AU - Berwig M FAU - Simon, Anke AU - Simon A FAU - Jänichen, Jenny AU - Jänichen J FAU - Hallensleben, Nina AU - Hallensleben N FAU - Nickel, Witiko AU - Nickel W FAU - Hinz, Andreas AU - Hinz A FAU - Brähler, Elmar AU - Brähler E FAU - Gertz, Hermann-Josef AU - Gertz HJ LA - eng SI - ClinicalTrials.gov/NCT01690117 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140212 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 SB - IM MH - *Adaptation, Psychological MH - Alzheimer Disease/epidemiology/*psychology/*therapy MH - Caregivers/*psychology MH - Early Medical Intervention/*methods MH - Germany/epidemiology MH - Home Care Services/*standards MH - Humans PMC - PMC3925255 EDAT- 2014/02/14 06:00 MHDA- 2014/10/10 06:00 PMCR- 2014/02/12 CRDT- 2014/02/14 06:00 PHST- 2014/01/23 00:00 [received] PHST- 2014/02/10 00:00 [accepted] PHST- 2014/02/14 06:00 [entrez] PHST- 2014/02/14 06:00 [pubmed] PHST- 2014/10/10 06:00 [medline] PHST- 2014/02/12 00:00 [pmc-release] AID - 1471-2318-14-21 [pii] AID - 10.1186/1471-2318-14-21 [doi] PST - epublish SO - BMC Geriatr. 2014 Feb 12;14:21. doi: 10.1186/1471-2318-14-21. PMID- 28750428 OWN - NLM STAT- MEDLINE DCOM- 20180905 LR - 20190305 IS - 1439-3646 (Electronic) IS - 0947-7349 (Linking) VI - 126 IP - 3 DP - 2018 Mar TI - Experiences in Sensor-Augmented Pump Therapy in Families with two Children with Type 1 diabetes: A Qualitative Study. PG - 162-167 LID - 10.1055/s-0043-110479 [doi] AB - BACKGROUND: Caring for a child with type 1 diabetes is a tremendous challenge for a family. The aim of the study was to explore the experiences of transition to sensor-augmented pump therapy (SAP) in families with 2 affected children and the internal and external conditions which potentially impede or facilitate the adjustment process. METHODS: 5 families (9 parents, 8 children and adolescents) who used the SAP technology for 6 months were interviewed to describe their experiences. The interviews were analysed using thematic content analysis. RESULTS: Qualitative analysis of the transcribed interviews revealed that the adaptation process to SAP consisted of several phases and differed among families. There were benefits as well as hassles of using SAP with regard to managing the diabetes, and psychosocial issues: school and peer relations, as well as family relations. While parents clearly regarded the improved metabolic control and hypoglycaemic safety as the most important benefits of SAP, the hassles reported as most important covered a wide range, from technical problems of the system to family conflicts. On the whole, families rated the experience of using SAP as a positive one, with most recommending SAP to other families as long as they were willing to come to terms with the technology and commit to the work and time involved. CONCLUSION: Sensor-augmented pump therapy can be extremely beneficial and a resource for families who care for more than one child with diabetes. During the adaptation process there is a great need of education and frequent follow-up e. g., by telemedical support. CI - © Georg Thieme Verlag KG Stuttgart · New York. FAU - Bomba, Franziska AU - Bomba F AD - Department of Paediatrics and Adolescent Medicine, University of Luebeck, Luebeck, Germany. FAU - Müller-Godeffroy, Esther AU - Müller-Godeffroy E AD - Department of Paediatrics and Adolescent Medicine, University of Luebeck, Luebeck, Germany. FAU - von Sengbusch, Simone AU - von Sengbusch S AD - Department of Paediatrics and Adolescent Medicine, University of Luebeck, Luebeck, Germany. LA - eng PT - Journal Article DEP - 20170727 PL - Germany TA - Exp Clin Endocrinol Diabetes JT - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JID - 9505926 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adolescent MH - Adult MH - Blood Glucose Self-Monitoring/*psychology/standards MH - Child MH - Diabetes Mellitus, Type 1/*drug therapy/nursing MH - Family/*psychology MH - Female MH - Humans MH - Hypoglycemic Agents/*administration & dosage MH - Insulin/*administration & dosage MH - Insulin Infusion Systems/*psychology/standards MH - Male MH - Patient Acceptance of Health Care/*psychology MH - *Patient Satisfaction MH - Qualitative Research MH - Telemedicine COIS- FB and EMG have no relevant financial relationships to disclose. SVS received payment as a consultant from Medtronic, Abbott and NovoNordisk and received honoraria for giving lectures from Astra Zeneca, Bayer Healthcare, Medtronic, Merck Serono, NovoNordisk, Pfizer, Roche diagnostics, and Sanofi. The companies have not been involved in the design, conduct or analysis of the study or the manuscript preparation. The study was sponsored by a research grant of the Damp foundation (Dampstiftung, Kiel, Germany). Medtronic (Meerbusch, Germany) provided 3 ParadigmMiniMedVEO TM pumps free of charge and Elinte(®) sensors at a discounted price. Neither the Damp foundation nor Medtronic have been involved in the design, conduct or analysis of the study or the manuscript preparation. EDAT- 2017/07/28 06:00 MHDA- 2018/09/06 06:00 CRDT- 2017/07/28 06:00 PHST- 2017/07/28 06:00 [pubmed] PHST- 2018/09/06 06:00 [medline] PHST- 2017/07/28 06:00 [entrez] AID - 10.1055/s-0043-110479 [doi] PST - ppublish SO - Exp Clin Endocrinol Diabetes. 2018 Mar;126(3):162-167. doi: 10.1055/s-0043-110479. Epub 2017 Jul 27. PMID- 22382190 OWN - NLM STAT- MEDLINE DCOM- 20120612 LR - 20220317 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 135 IP - 1 DP - 2012 TI - Sex worker-led structural interventions in India: a case study on addressing violence in HIV prevention through the Ashodaya Samithi collective in Mysore. PG - 98-106 AB - BACKGROUND & OBJECTIVES: Structural interventions have the capacity to improve the outcomes of HIV/AIDS interventions by changing the social, economic, political or environmental factors that determine risk and vulnerability. Marginalized groups face disproportionate barriers to health, and sex workers are among those at highest risk of HIV in India. Evidence in India and globally has shown that sex workers face violence in many forms ranging from verbal, psychological and emotional abuse to economic extortion, physical and sexual violence and this is directly linked to lower levels of condom use and higher levels of sexually transmitted infections (STIs), the most critical determinants of HIV risk. We present here a case study of an intervention that mobilized sex workers to lead an HIV prevention response that addresses violence in their daily lives. METHODS: This study draws on ethnographic research and project monitoring data from a community-led structural intervention in Mysore, India, implemented by Ashodaya Samithi. Qualitative and quantitative data were used to characterize baseline conditions, community responses and subsequent outcomes related to violence. RESULTS: In 2004, the incidence of reported violence by sex workers was extremely high (> 8 incidents per sex worker, per year) but decreased by 84 per cent over 5 years. Violence by police and anti-social elements, initially most common, decreased substantially after a safe space was established for sex workers to meet and crisis management and advocacy were initiated with different stakeholders. Violence by clients, decreased after working with lodge owners to improve safety. However, initial increases in intimate partner violence were reported, and may be explained by two factors: (i) increased willingness to report such incidents; and (ii) increased violence as a reaction to sex workers' growing empowerment. Trafficking was addressed through the establishment of a self-regulatory board (SRB). The community's progressive response to violence was enabled by advancing community mobilization, ensuring community ownership of the intervention, and shifting structural vulnerabilities, whereby sex workers increasingly engaged key actors in support of a more enabling environment. INTERPRETATION & CONCLUSIONS: Ashodaya's community-led response to violence at multiple levels proved highly synergistic and effective in reducing structural violence. FAU - Reza-Paul, Sushena AU - Reza-Paul S AD - University of Manitoba, Department of Community Health Sciences, Winnipeg, Manitoba, Canada. rezapaul@cc.umanitoba.ca FAU - Lorway, Rob AU - Lorway R FAU - O'Brien, Nadia AU - O'Brien N FAU - Lazarus, Lisa AU - Lazarus L FAU - Jain, Jinendra AU - Jain J FAU - Bhagya, M AU - Bhagya M FAU - Fathima Mary, P AU - Fathima Mary P FAU - Venukumar, K T AU - Venukumar KT FAU - Raviprakash, K N AU - Raviprakash KN FAU - Baer, James AU - Baer J FAU - Steen, Richard AU - Steen R LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - India TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Female MH - *HIV Infections/prevention & control/psychology/virology MH - Humans MH - India MH - Organizations MH - Police MH - Power, Psychological MH - Safe Sex MH - Sex Workers/education/*psychology MH - Sexual Behavior/*psychology MH - *Violence PMC - PMC3307193 EDAT- 2012/03/03 06:00 MHDA- 2012/06/13 06:00 PMCR- 2012/01/01 CRDT- 2012/03/03 06:00 PHST- 2012/03/03 06:00 [entrez] PHST- 2012/03/03 06:00 [pubmed] PHST- 2012/06/13 06:00 [medline] PHST- 2012/01/01 00:00 [pmc-release] AID - IndianJMedRes_2012_135_1_98_93431 [pii] AID - IJMR-135-98 [pii] AID - 10.4103/0971-5916.93431 [doi] PST - ppublish SO - Indian J Med Res. 2012;135(1):98-106. doi: 10.4103/0971-5916.93431. PMID- 15944888 OWN - NLM STAT- MEDLINE DCOM- 20070917 LR - 20191026 IS - 1938-1352 (Electronic) IS - 0748-7711 (Linking) VI - 42 IP - 2 DP - 2005 Mar-Apr TI - Electromyographic activity imbalances between contralateral back muscles: An assessment of measurement properties. PG - 235-50 AB - Electromyographic (EMG) contralateral imbalances of back muscles are often interpreted as an aberrant back muscle pattern related to back pain. This study assessed different measurement properties (influence of the control of asymmetric efforts and of the force level, reliability, and sensitivity to low back status) of EMG imbalance parameters. Healthy controls (n = 34) and chronic low back pain subjects (n = 55) stood in a dynamometer measuring the principal (extension) and coupled (lateral bending, axial rotation) L5/S1 moments during isometric trunk extension efforts. The results showed that back pain subjects did not produce higher coupled moments than controls. Providing feedback of the axial rotation moment to correct asymmetric efforts during the task did not reduce EMG contralateral imbalances, except for some extreme cases. Normalized EMG imbalance parameters remain relatively constant between 40% and 80% of the maximal voluntary contraction. The reliability of EMG imbalance parameters was moderate, at best. Finally, neither low back status nor pain location had an effect on EMG contralateral imbalances. We conclude that the clinical relevance of EMG contralateral imbalances of back muscles remains to be established. FAU - Larivière, Christian AU - Larivière C AD - Occupational Health and Safety Research Institute Robert-Sauvé, Montreal, Quebec, Canada. lariviere.christian@irsst.qc.ca FAU - Gagnon, Denis AU - Gagnon D FAU - Arsenault, A Bertrand AU - Arsenault AB FAU - Gravel, Denis AU - Gravel D FAU - Loisel, Patrick AU - Loisel P LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Rehabil Res Dev JT - Journal of rehabilitation research and development JID - 8410047 SB - IM MH - Adult MH - Analysis of Variance MH - Back Pain/*diagnosis/*physiopathology MH - Biofeedback, Psychology MH - Chronic Disease MH - Electromyography MH - Humans MH - Isometric Contraction/physiology MH - Lumbosacral Region/*physiopathology MH - Male MH - Muscle, Skeletal/*physiopathology MH - Pain Measurement MH - Reproducibility of Results EDAT- 2005/06/10 09:00 MHDA- 2007/09/18 09:00 CRDT- 2005/06/10 09:00 PHST- 2005/06/10 09:00 [pubmed] PHST- 2007/09/18 09:00 [medline] PHST- 2005/06/10 09:00 [entrez] AID - 10.1682/jrrd.2004.01.0008 [doi] PST - ppublish SO - J Rehabil Res Dev. 2005 Mar-Apr;42(2):235-50. doi: 10.1682/jrrd.2004.01.0008. PMID- 12443835 OWN - NLM STAT- MEDLINE DCOM- 20030328 LR - 20190916 IS - 0378-5122 (Print) IS - 0378-5122 (Linking) VI - 43 IP - 3 DP - 2002 Nov 20 TI - The role of treatment intentions and concerns about side effects in women's decision to discontinue postmenopausal hormone therapy. PG - 183-94 AB - OBJECTIVES: To investigate the factors that influence women's decisions about hormone therapy use and the duration of use, in particular the effect of women's reasons for initiating hormone therapy, the source of information about hormones, women's symptom experience, and their concerns about side effects from hormone therapy. METHODS: Eight hundred and sixteen women aged 45-59 who began hormone therapy between July 1993 and June 1995 in a Massachusetts health maintenance organization were followed for two years from the day they received a prescription for estrogen. This cohort has been previously studied for health, treatment and demographic determinants of hormone therapy discontinuation. In March 1999, these women were mailed a questionnaire containing closed and open-ended questions. 449 women (55%) completed the survey. Discrete-time hazards models were used to identify determinants of discontinuation, controlling for medical predictors of survey nonresponse. RESULTS: Women's assessment of the difficulty of their decision to use hormone therapy (RR=1.25 for each point on a 7-point scale, 95% CI: 1.16, 1.35) was associated with discontinuation. Women who described their decision as extremely difficult had the greatest likelihood of discontinuing. The importance placed on preventing osteoporosis (RR=0.93 for each point on a 7-point scale, 95% CI: 0.86, 0.99) and cardiovascular disease (RR=0.94 for each point on a 7-point scale, 95% CI: 0.88, 0.99) were also statistically significant predictors of discontinuation. Women for whom the prevention of osteoporosis and cardiovascular disease were extremely important in deciding to use hormone therapy were the most likely to continue using hormones. Concerns about the return of monthly bleeding (RR=3.00, 95% CI: 1.45, 6.17) and weight gain (RR=2.06, 95% CI: 1.16, 3.67) at the time hormone therapy was initiated, but not the actual experience of these side effects while using hormones, were associated with a higher rate of discontinuation. Symptoms around the time of initiating hormone therapy, including the perceived severity of the symptom, were not statistically associated with discontinuation. CONCLUSIONS: Discontinuation of hormone therapy is the result of a complex process of decision-making that is influenced by the value placed on the prevention of osteoporosis and cardiovascular disease at the time of initiation and women's perceptions and interpretations of side effects. Concerns about the potential side effects of hormone therapy, in particular weight gain and monthly bleeding, lead women to discontinue hormone therapy. FAU - Reynolds, Robert F AU - Reynolds RF AD - Safety Evaluation and Epidemiology, Pfizer, Inc., 235 East 42nd Street, MS 150-3-72, New York, NY 10017, USA. robert.reynolds@pfizer.com FAU - Obermeyer, Carla Makhlouf AU - Obermeyer CM FAU - Walker, Alexander M AU - Walker AM FAU - Guilbert, Daniel AU - Guilbert D LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Maturitas JT - Maturitas JID - 7807333 SB - IM MH - Cardiovascular Diseases/prevention & control MH - *Decision Making MH - Estrogen Replacement Therapy/*adverse effects/*psychology MH - Female MH - Health Maintenance Organizations MH - Humans MH - Massachusetts MH - Middle Aged MH - Osteoporosis, Postmenopausal/prevention & control MH - Surveys and Questionnaires MH - *Treatment Refusal EDAT- 2002/11/22 04:00 MHDA- 2003/03/29 05:00 CRDT- 2002/11/22 04:00 PHST- 2002/11/22 04:00 [pubmed] PHST- 2003/03/29 05:00 [medline] PHST- 2002/11/22 04:00 [entrez] AID - S0378512202002049 [pii] AID - 10.1016/s0378-5122(02)00204-9 [doi] PST - ppublish SO - Maturitas. 2002 Nov 20;43(3):183-94. doi: 10.1016/s0378-5122(02)00204-9. PMID- 28854130 OWN - NLM STAT- MEDLINE DCOM- 20171204 LR - 20220321 IS - 1087-0415 (Electronic) IS - 1081-0730 (Linking) VI - 22 IP - sup1 DP - 2017 TI - Facilitators and Barriers to Community Acceptance of Safe, Dignified Medical Burials in the Context of an Ebola Epidemic, Sierra Leone, 2014. PG - 24-30 LID - 10.1080/10810730.2016.1209601 [doi] AB - Sierra Leone was heavily affected by the Ebola epidemic, with over 14,000 total cases. Given that corpses of people who have died from Ebola are highly infectious and given the extremely high risk of Ebola transmission associated with direct contact with bodies of people who have died of Ebola, community acceptance of safe, dignified medical burials was one of the important components of efforts to stop the Ebola epidemic in Sierra Leone. Information on barriers and facilitators for community acceptance of safe, dignified medical burials is limited. A rapid qualitative assessment using focus group discussions (FGDs) explored community knowledge, attitudes, and practices towards safe and dignified burials in seven chiefdoms in Bo District, Sierra Leone. In total, 63 FGDs were conducted among three groups: women >25 years of age, men >25 years of age, and young adults 19-25 years of age. In addition to concerns about breaking cultural traditions, barriers to safe burial acceptance included concerns by family members about being able to view the burial, perceptions that bodies were improperly handled, and fear that stigma may occur if a family member receives a safe, dignified medical burial. Participants suggested that providing opportunities for community members to participate in safe and dignified burials would improve community acceptance. FAU - Lee-Kwan, Seung Hee AU - Lee-Kwan SH AD - a Epidemic Intelligence Service , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. AD - b Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - DeLuca, Nickolas AU - DeLuca N AD - c Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Bunnell, Rebecca AU - Bunnell R AD - d Division of Global Health Protection, Center for Global Health , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Clayton, Heather B AU - Clayton HB AD - e Division of Adolescent and School Health, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Turay, Alhaji Sayui AU - Turay AS AD - f Bo District Health Management Team , Sierra Leone Ministry of Health and Sanitation , Bo , Sierra Leone. FAU - Mansaray, Yayah AU - Mansaray Y AD - g Bo Social Mobilization Team , Bo , Sierra Leone. LA - eng PT - Journal Article PL - United States TA - J Health Commun JT - Journal of health communication JID - 9604100 MH - Adult MH - Burial/*methods MH - Community Participation/*psychology MH - Cultural Characteristics MH - Epidemics/*prevention & control MH - Female MH - Focus Groups MH - Health Knowledge, Attitudes, Practice MH - Hemorrhagic Fever, Ebola/epidemiology/*prevention & control/psychology MH - Humans MH - Male MH - *Safety MH - Sierra Leone/epidemiology MH - Social Stigma MH - Young Adult EDAT- 2017/08/31 06:00 MHDA- 2017/12/05 06:00 CRDT- 2017/08/31 06:00 PHST- 2017/08/31 06:00 [entrez] PHST- 2017/08/31 06:00 [pubmed] PHST- 2017/12/05 06:00 [medline] AID - 10.1080/10810730.2016.1209601 [doi] PST - ppublish SO - J Health Commun. 2017;22(sup1):24-30. doi: 10.1080/10810730.2016.1209601. PMID- 20112854 OWN - NLM STAT- MEDLINE DCOM- 20100304 LR - 20151119 IS - 0019-5847 (Print) IS - 0019-5847 (Linking) VI - 107 IP - 7 DP - 2009 Jul TI - Quality of life as a key indicator of patient satisfaction and treatment compliance in people with type 2 diabetes mellitus in the IMPROVE study: a multicentre, open label, non-randomised, observational trial. PG - 464-70 AB - Diabetes is a debilitating chronic illness having multiple impacts on physical and mental well-being of patients. When treating chronic conditions like diabetes, psychosocial aspects and quality of life (QoL) have to be considered; however, these receive less attention due to various reasons. Patients with diabetic complications have increased levels of depression and decreased QoL This necessitates evaluating QoL of patient which now is used as a primary or secondary end point in clinical trials eg, Diab-MedSat QoL questionnaire used in diabetes. At some point all diabetic patients may require insulin to control hyperglycaemia and disease progression. The traditional insulin syringe and needle delivery system has been the principal barrier in the treatment of diabetes as it was not well accepted among the patients due to various reasons. A success over this approach has been pen like devices like FlexPen and Novopen3 which are becoming more popular than the conventional syringe-and-needles as they have several advantages like, easy to carry, use, maintain and also reduces administrative errors ensuring accurate doses are delivered. The objective of IMPROVE study is to evaluate the safety and effectiveness of biphasic insulin aspart (NovoMix 30) in normal clinical practice conditions, in India. This is an open label, non-randomised, non-interventional, observational, safety and effectiveness study in approximately 17,995 patients with type 2 diabetes mellitus. A cohort of Indian patients (n = 349) from all 4 geographical locations (North, West, East and South of India) were administered QoL instrument Diab-MedSat at baseline and 346 patients at final visit (n = 346) to assess their satisfaction with the treatment they received. The results were included in the final statistical analysis as additional outcome variables. The Diab-MedSat Novo Nordisk June 2004 English (UK) version is used. The Diab-MedSat has 21 items that need to be answered and it is scored as an overall score (all 21 items) as well as three subscale scores regarding burden (11 items), symptoms (5 items), efficacy (5 items). The complete analysis took into account all 21 items of Diab-MedSat questionnaire with their subscales. Analyses of the cohort showed higher patient satisfaction among the patients administered Diab-MedSat questionnaire from baseline (n = 349) to final visit (n = 346). The mean of overall score was 52.33 (baseline visit) versus 79.03 (final visit). The difference in the overall score and sub parameters like burden, symptoms and efficacy between the baseline and final visits were statistically significant (p-value < 0.001). The mean value of difference in overall score between the baseline visit and final visit was 26.73 +/- 20.83; while the difference for burden, symptoms and efficacy were respectively 27.86 +/- 20.81, 19.75 +/- 20.94 and 32.87 +/- 28.08. A fairly clear picture emerged that the use of biphasic insulin aspart resulted in improved QoL of the patients substantially. This is demonstrated in the results for all the parameters that were used like symptoms, efficacy and burden. The overall number of extremely satisfied patients had increased from 5.4% in the baseline visit to 91% in the final visit. This unambiguously proves that the satisfaction of patients on biphasic insulin aspart (NovoMix 30) is beyond question. FAU - Mukherjee, Apurba Kumar AU - Mukherjee AK AD - Diabetes Clinic, Department of Medicine, R G Kar Medical College, Kolkata 700004. FAU - Reddy, Vijay Shekar AU - Reddy VS FAU - Shah, Siddharth AU - Shah S FAU - Jhingan, A K AU - Jhingan AK FAU - Ramakrishnan, P AU - Ramakrishnan P FAU - Prusty, Vinay AU - Prusty V FAU - Singh, Naorem Santa AU - Singh NS LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PL - India TA - J Indian Med Assoc JT - Journal of the Indian Medical Association JID - 7505608 RN - 0 (Biphasic Insulins) RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) RN - 0 (insulin aspart, insulin aspart protamine drug combination 30:70) RN - 53027-39-7 (Insulin, Isophane) RN - D933668QVX (Insulin Aspart) SB - IM MH - Biphasic Insulins MH - Diabetes Mellitus, Type 2/*drug therapy/*psychology MH - Female MH - Humans MH - Hypoglycemic Agents/*therapeutic use MH - India MH - Insulin/*analogs & derivatives/therapeutic use MH - Insulin Aspart MH - Insulin, Isophane MH - Male MH - *Patient Compliance MH - *Patient Satisfaction MH - *Quality of Life MH - Surveys and Questionnaires EDAT- 2010/02/02 06:00 MHDA- 2010/03/05 06:00 CRDT- 2010/02/02 06:00 PHST- 2010/02/02 06:00 [entrez] PHST- 2010/02/02 06:00 [pubmed] PHST- 2010/03/05 06:00 [medline] PST - ppublish SO - J Indian Med Assoc. 2009 Jul;107(7):464-70. PMID- 14733987 OWN - NLM STAT- MEDLINE DCOM- 20040413 LR - 20191108 IS - 0022-4375 (Print) IS - 0022-4375 (Linking) VI - 34 IP - 5 DP - 2003 TI - Causal attributions of Ghanaian industrial workers for accident occurrence: miners and non-miners perspective. PG - 533-8 AB - PROBLEM: Reports from the accident literature indicate that accident rates tend to vary with type of occupation. The mining industry has been recorded as the most dangerous with a high disabling injury rate. This observation has been attributed to the extremely stressful conditions under which miners work. Besides, the intimidating work environment in the mines has been insinuated to invoke a sense of helplessness, fatalism and hence defensive causal attributions for accident occurrences. METHOD: This study compared causal attributions between accident victims in Ghana's mining industry with their counterparts in textile factories. T values and Chi-square were employed to test for statistically significant differences between the two groups of accident victims. RESULTS: Findings indicate that there is no difference between the causal attributions for miners and non-miners. IMPACT ON INDUSTRY: Accident frequency and occupational type have no impact on causal attributions. FAU - Gyekye, Seth Ayim AU - Gyekye SA AD - Department of Social Psychology, University of Helsinki, Neitsytsaarentie 8 D 22, 00960 96 Helsinki, Finland. gyekye@sato.helsinki.fi LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - J Safety Res JT - Journal of safety research JID - 1264241 SB - IM MH - Accidents, Occupational/*prevention & control/*statistics & numerical data MH - Adult MH - Causality MH - Ghana MH - Humans MH - Male MH - Mining/*statistics & numerical data MH - Risk Factors MH - Surveys and Questionnaires EDAT- 2004/01/22 05:00 MHDA- 2004/04/14 05:00 CRDT- 2004/01/22 05:00 PHST- 2004/01/22 05:00 [pubmed] PHST- 2004/04/14 05:00 [medline] PHST- 2004/01/22 05:00 [entrez] AID - S0022437503000744 [pii] AID - 10.1016/j.jsr.2003.03.002 [doi] PST - ppublish SO - J Safety Res. 2003;34(5):533-8. doi: 10.1016/j.jsr.2003.03.002. PMID- 16125634 OWN - NLM STAT- MEDLINE DCOM- 20051013 LR - 20061115 IS - 1062-0303 (Print) IS - 1062-0303 (Linking) VI - 23 IP - 3 DP - 2005 Sep TI - Upsetting the apple cart: a community anticoagulation clinic survey of life event factors that undermine safe therapy. PG - 105-11 AB - Anticoagulation therapy is a life-enhancing therapy for patients who are at risk for embolic events secondary to atrial fibrillation, valve replacement, and other comorbidities. Clinicians are motivated to decrease the amount of time that patients are either under- or over-anticoagulated, common conditions that decrease patient safety at either extreme. The primary purpose of this descriptive study was to examine the relationship between personal life event factors as measured by Norbeck's Life Events Questionnaire, core demographics such as age and income, and anticoagulation regulation. Although many factors affect anticoagulation therapy, the precise impact of life events, positive or negative, is unknown. The salient findings of this study (n = 202) showed a small, though statistically significant, inverse relationship (r = -0.184, P < .01) between negative life events and decreased time within therapeutic international normalized ratio. Total Life Event scores showed a statistically significant inverse relationship (r = -0.159, P < .05) to international normalized ratio time within therapeutic level. Lower income was inversely associated with higher negative Life Event scores (r = -0.192, P < .01). The findings demonstrate the need for strategies that address the potential impact of life events in conjunction with coexisting screening measures used in anticoagulation clinics. Implications for this study are limited by lack of methodology documenting concurrent social support factors and limitations of the research tool to reflect life event issues specific to outpatient seniors. FAU - Edmundson, Sarah AU - Edmundson S AD - Dominican Hospital, Catholic Healthcare West, Santa Cruz, California, USA. FAU - Stuenkel, Diane L AU - Stuenkel DL FAU - Connolly, Phyllis M AU - Connolly PM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Vasc Nurs JT - Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing JID - 9014475 RN - 0 (Anticoagulants) MH - Adult MH - Aged MH - Aged, 80 and over MH - Ambulatory Care Facilities MH - Anticoagulants/*administration & dosage MH - California MH - *Drug Monitoring MH - Female MH - Humans MH - *Life Change Events MH - Male MH - Middle Aged MH - *Patient Compliance/psychology MH - Safety Management EDAT- 2005/08/30 09:00 MHDA- 2005/10/14 09:00 CRDT- 2005/08/30 09:00 PHST- 2005/08/30 09:00 [pubmed] PHST- 2005/10/14 09:00 [medline] PHST- 2005/08/30 09:00 [entrez] AID - S1062-0303(05)00100-7 [pii] AID - 10.1016/j.jvn.2005.07.001 [doi] PST - ppublish SO - J Vasc Nurs. 2005 Sep;23(3):105-11. doi: 10.1016/j.jvn.2005.07.001. PMID- 11481961 OWN - NLM STAT- MEDLINE DCOM- 20010830 LR - 20131121 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 140 IP - 7 DP - 2001 Jul TI - [Hospital-at-home as a solution for the treatment requirements of acute exacerbation in multiple sclerosis]. PG - 603-6, 678 AB - Cooperation between the Multiple Sclerosis center at the Carmel medical center and the Hospital-at-Home (H.H) department of the continuing care unit in the Haifa and Western Galilee district of the Clalit Health Services has made it possible to give methylprednisolone intravenously to Multiple Sclerosis (M.S) patients during an acute exacerbation of the disease, in their home. In this study, we describe the joint work of the two centers. We have summarized 30 treatment courses given to 26 patients in their homes, following referral by the M.S. center, in the year 1999. The aims of the study included assessing satisfaction, safety and cost-effectiveness in a treatment course in the HH framework, as compared to the same treatment being conducted in the framework of hospitalization in various neurological departments, as was done in the past in the same group of patients. The expenses involved in HH for this group of patients were only 14% of the parallel treatment in the hospital (a savings of 86%). The treatment has proven to be extremely safe. There were no side-effects that required returning patients to the hospital, and the treatment was given in conditions of maximum comfort for the patient and his family. A telephone survey was conducted, which compared the satisfaction with the HH treatment, and the burden caused the patient's family to prior hospitalization for the same treatment. For all of the parameters examined, greater satisfaction was distinctly proven in the HH treatment. In light of these findings, we can conclude that giving methylprednisolone intravenously to M.S patients during an acute exacerbation, in the HH framework, is a safe and cost effective treatment, preferred by the patient and his family. FAU - Steinmetz, D AU - Steinmetz D AD - Hospital-at-Home Department, Continuing Care Unit, Clalit Health Services, Haifa and Western Galilee District, Haifa, Israel. FAU - Edelstein, H AU - Edelstein H FAU - Dishon, S AU - Dishon S FAU - Berkovitz, E AU - Berkovitz E FAU - Almany, A AU - Almany A FAU - Miller, A AU - Miller A LA - heb PT - English Abstract PT - Journal Article PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Caregivers/psychology MH - Continuity of Patient Care/economics/*organization & administration MH - Cost-Benefit Analysis MH - Disease Progression MH - Family MH - Home Care Services/economics/*organization & administration MH - Humans MH - Injections, Intravenous MH - Israel MH - Methylprednisolone/administration & dosage/*therapeutic use MH - Multiple Sclerosis/drug therapy/*physiopathology/*therapy MH - Patient Satisfaction MH - Safety EDAT- 2001/08/03 10:00 MHDA- 2001/08/31 10:01 CRDT- 2001/08/03 10:00 PHST- 2001/08/03 10:00 [pubmed] PHST- 2001/08/31 10:01 [medline] PHST- 2001/08/03 10:00 [entrez] PST - ppublish SO - Harefuah. 2001 Jul;140(7):603-6, 678. PMID- 27490260 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220131 IS - 1748-5908 (Electronic) IS - 1748-5908 (Linking) VI - 11 Suppl 2 IP - Suppl 2 DP - 2016 Aug 1 TI - Proceedings of the 8th Annual Conference on the Science of Dissemination and Implementation : Washington, DC, USA. 14-15 December 2015. PG - 100 LID - 10.1186/s13012-016-0452-0 [doi] LID - 100 AB - A1 Introduction to the 8(th) Annual Conference on the Science of Dissemination and Implementation: Optimizing Personal and Population Health David Chambers, Lisa Simpson D1 Discussion forum: Population health D&I research Felicia Hill-Briggs D2 Discussion forum: Global health D&I research Gila Neta, Cynthia Vinson D3 Discussion forum: Precision medicine and D&I research David Chambers S1 Predictors of community therapists’ use of therapy techniques in a large public mental health system Rinad Beidas, Steven Marcus, Gregory Aarons, Kimberly Hoagwood, Sonja Schoenwald, Arthur Evans, Matthew Hurford, Ronnie Rubin, Trevor Hadley, Frances Barg, Lucia Walsh, Danielle Adams, David Mandell S2 Implementing brief cognitive behavioral therapy (CBT) in primary care: Clinicians' experiences from the field Lindsey Martin, Joseph Mignogna, Juliette Mott, Natalie Hundt, Michael Kauth, Mark Kunik, Aanand Naik, Jeffrey Cully S3 Clinician competence: Natural variation, factors affecting, and effect on patient outcomes Alan McGuire, Dominique White, Tom Bartholomew, John McGrew, Lauren Luther, Angie Rollins, Michelle Salyers S4 Exploring the multifaceted nature of sustainability in community-based prevention: A mixed-method approach Brittany Cooper, Angie Funaiole S5 Theory informed behavioral health integration in primary care: Mixed methods evaluation of the implementation of routine depression and alcohol screening and assessment Julie Richards, Amy Lee, Gwen Lapham, Ryan Caldeiro, Paula Lozano, Tory Gildred, Carol Achtmeyer, Evette Ludman, Megan Addis, Larry Marx, Katharine Bradley S6 Enhancing the evidence for specialty mental health probation through a hybrid efficacy and implementation study Tonya VanDeinse, Amy Blank Wilson, Burgin Stacey, Byron Powell, Alicia Bunger, Gary Cuddeback S7 Personalizing evidence-based child mental health care within a fiscally mandated policy reform Miya Barnett, Nicole Stadnick, Lauren Brookman-Frazee, Anna Lau S8 Leveraging an existing resource for technical assistance: Community-based supervisors in public mental health Shannon Dorsey, Michael Pullmann S9 SBIRT implementation for adolescents in urban federally qualified health centers: Implementation outcomes Shannon Mitchell, Robert Schwartz, Arethusa Kirk, Kristi Dusek, Marla Oros, Colleen Hosler, Jan Gryczynski, Carolina Barbosa, Laura Dunlap, David Lounsbury, Kevin O'Grady, Barry Brown S10 PANEL: Tailoring Implementation Strategies to Context - Expert recommendations for tailoring strategies to context Laura Damschroder, Thomas Waltz, Byron Powell S11 PANEL: Tailoring Implementation Strategies to Context - Extreme facilitation: Helping challenged healthcare settings implement complex programs Mona Ritchie S12 PANEL: Tailoring Implementation Strategies to Context - Using menu-based choice tasks to obtain expert recommendations for implementing three high-priority practices in the VA Thomas Waltz S13 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Siri, rate my therapist: Using technology to automate fidelity ratings of motivational interviewing David Atkins, Zac E. Imel, Bo Xiao, Doğan Can, Panayiotis Georgiou, Shrikanth Narayanan S14 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Identifying indicators of implementation quality for computer-based ratings Cady Berkel, Carlos Gallo, Irwin Sandler, C. Hendricks Brown, Sharlene Wolchik, Anne Marie Mauricio S15 PANEL: The Use of Technology to Improve Efficient Monitoring of Implementation of Evidence-based Programs - Improving implementation of behavioral interventions by monitoring emotion in spoken speech Carlos Gallo, C. Hendricks Brown, Sanjay Mehrotra S16 Scorecards and dashboards to assure data quality of health management information system (HMIS) using R Dharmendra Chandurkar, Siddhartha Bora, Arup Das, Anand Tripathi, Niranjan Saggurti, Anita Raj S17 A big data approach for discovering and implementing patient safety insights Eric Hughes, Brian Jacobs, Eric Kirkendall S18 Improving the efficacy of a depression registry for use in a collaborative care model Danielle Loeb, Katy Trinkley, Michael Yang, Andrew Sprowell, Donald Nease S19 Measurement feedback systems as a strategy to support implementation of measurement-based care in behavioral health Aaron Lyon, Cara Lewis, Meredith Boyd, Abigail Melvin, Semret Nicodimos, Freda Liu, Nathanial Jungbluth S20 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Common loop assay: Methods of supporting learning collaboratives Allen Flynn S21 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Innovating audit and feedback using message tailoring models for learning health systems Zach Landis-Lewis S22 PANEL: Implementation Science and Learning Health Systems: Intersections and Commonalities - Implementation science and learning health systems: Connecting the dots Anne Sales S23 Facilitation activities of Critical Access Hospitals during TeamSTEPPS implementation Jure Baloh, Marcia Ward, Xi Zhu S24 Organizational and social context of federally qualified health centers and variation in maternal depression outcomes Ian Bennett, Jurgen Unutzer, Johnny Mao, Enola Proctor, Mindy Vredevoogd, Ya-Fen Chan, Nathaniel Williams, Phillip Green S25 Decision support to enhance treatment of hospitalized smokers: A randomized trial Steven Bernstein, June-Marie Rosner, Michelle DeWitt, Jeanette Tetrault, James Dziura, Allen Hsiao, Scott Sussman, Patrick O’Connor, Benjamin Toll S26 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A patient-centered approach to successful community transition after catastrophic injury Michael Jones, Julie Gassaway S27 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - Conducting PCOR to integrate mental health and cancer screening services in primary care Jonathan Tobin S28 PANEL: Developing Sustainable Strategies for the Implementation of Patient-Centered Care across Diverse US Healthcare Systems - A comparative effectiveness trial of optimal patient-centered care for US trauma care systems Douglas Zatzick S29 Preferences for in-person communication among patients in a multi-center randomized study of in-person versus telephone communication of genetic test results for cancer susceptibility Angela R Bradbury, Linda Patrick-Miller, Brian Egleston, Olufunmilayo I Olopade, Michael J Hall, Mary B Daly, Linda Fleisher, Generosa Grana, Pamela Ganschow, Dominique Fetzer, Amanda Brandt, Dana Farengo-Clark, Andrea Forman, Rikki S Gaber, Cassandra Gulden, Janice Horte, Jessica Long, Rachelle Lorenz Chambers, Terra Lucas, Shreshtha Madaan, Kristin Mattie, Danielle McKenna, Susan Montgomery, Sarah Nielsen, Jacquelyn Powers, Kim Rainey, Christina Rybak, Michelle Savage, Christina Seelaus, Jessica Stoll, Jill Stopfer, Shirley Yao and Susan Domchek S30 Working towards de-implementation: A mixed methods study in breast cancer surveillance care Erin Hahn, Corrine Munoz-Plaza, Jianjin Wang, Jazmine Garcia Delgadillo, Brian Mittman Michael Gould S31Integrating evidence-based practices for increasing cancer screenings in safety-net primary care systems: A multiple case study using the consolidated framework for implementation research Shuting (Lily) Liang, Michelle C. Kegler, Megan Cotter, Emily Phillips, April Hermstad, Rentonia Morton, Derrick Beasley, Jeremy Martinez, Kara Riehman S32 Observations from implementing an mHealth intervention in an FQHC David Gustafson, Lisa Marsch, Louise Mares, Andrew Quanbeck, Fiona McTavish, Helene McDowell, Randall Brown, Chantelle Thomas, Joseph Glass, Joseph Isham, Dhavan Shah S33 A multicomponent intervention to improve primary care provider adherence to chronic opioid therapy guidelines and reduce opioid misuse: A cluster randomized controlled trial protocol Jane Liebschutz, Karen Lasser S34 Implementing collaborative care for substance use disorders in primary care: Preliminary findings from the summit study Katherine Watkins, Allison Ober, Sarah Hunter, Karen Lamp, Brett Ewing S35 Sustaining a task-shifting strategy for blood pressure control in Ghana: A stakeholder analysis Juliet Iwelunmor, Joyce Gyamfi, Sarah Blackstone, Nana Kofi Quakyi, Jacob Plange-Rhule, Gbenga Ogedegbe S36 Contextual adaptation of the consolidated framework for implementation research (CFIR) in a tobacco cessation study in Vietnam Pritika Kumar, Nancy Van Devanter, Nam Nguyen, Linh Nguyen, Trang Nguyen, Nguyet Phuong, Donna Shelley S37 Evidence check: A knowledge brokering approach to systematic reviews for policy Sian Rudge S38 Using Evidence Synthesis to Strengthen Complex Health Systems in Low- and Middle-Income Countries Etienne Langlois S39 Does it matter: timeliness or accuracy of results? The choice of rapid reviews or systematic reviews to inform decision-making Andrea Tricco S40 Evaluation of the veterans choice program using lean six sigma at a VA medical center to identify benefits and overcome obstacles Sherry Ball, Anne Lambert-Kerzner, Christine Sulc, Carol Simmons, Jeneen Shell-Boyd, Taryn Oestreich, Ashley O'Connor, Emily Neely, Marina McCreight, Amy Labebue, Doreen DiFiore, Diana Brostow, P. Michael Ho, David Aron S41 The influence of local context on multi-stakeholder alliance quality improvement activities: A multiple case study Jillian Harvey, Megan McHugh, Dennis Scanlon S42 Increasing physical activity in early care and education: Sustainability via active garden education (SAGE) Rebecca Lee, Erica Soltero, Nathan Parker, Lorna McNeill, Tracey Ledoux S43 Marking a decade of policy implementation: The successes and continuing challenges of a provincial school food and nutrition policy in Canada Jessie-Lee McIsaac, Kate MacLeod, Nicole Ata, Sherry Jarvis, Sara Kirk S44 Use of research evidence among state legislators who prioritize mental health and substance abuse issues Jonathan Purtle, Elizabeth Dodson, Ross Brownson S45 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 1 designs Brian Mittman, Geoffrey Curran S46 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 2 designs Geoffrey Curran S47 PANEL: Effectiveness-Implementation Hybrid Designs: Clarifications, Refinements, and Additional Guidance Based on a Systematic Review and Reports from the Field - Hybrid type 3 designs Jeffrey Pyne S48 Linking team level implementation leadership and implementation climate to individual level attitudes, behaviors, and implementation outcomes Gregory Aarons, Mark Ehrhart, Elisa Torres S49 Pinpointing the specific elements of local context that matter most to implementation outcomes: Findings from qualitative comparative analysis in the RE-inspire study of VA acute stroke care Edward Miech S50 The GO score: A new context-sensitive instrument to measure group organization level for providing and improving care Edward Miech S51 A research network approach for boosting implementation and improvement Kathleen Stevens, I.S.R.N. Steering Council S52 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - The value of qualitative methods in implementation research Alison Hamilton S53 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Learning evaluation: The role of qualitative methods in dissemination and implementation research Deborah Cohen S54 PANEL: Qualitative methods in D&I Research: Value, rigor and challenge - Qualitative methods in D&I research Deborah Padgett S55 PANEL: Maps & models: The promise of network science for clinical D&I - Hospital network of sharing patients with acute and chronic diseases in California Alexandra Morshed S56 PANEL: Maps & models: The promise of network science for clinical D&I - The use of social network analysis to identify dissemination targets and enhance D&I research study recruitment for pre-exposure prophylaxis for HIV (PrEP) among men who have sex with men Rupa Patel S57 PANEL: Maps & models: The promise of network science for clinical D&I - Network and organizational factors related to the adoption of patient navigation services among rural breast cancer care providers Beth Prusaczyk S58 A theory of de-implementation based on the theory of healthcare professionals’ behavior and intention (THPBI) and the becker model of unlearning David C. Aron, Divya Gupta, Sherry Ball S59 Observation of registered dietitian nutritionist-patient encounters by dietetic interns highlights low awareness and implementation of evidence-based nutrition practice guidelines Rosa Hand, Jenica Abram, Taylor Wolfram S60 Program sustainability action planning: Building capacity for program sustainability using the program sustainability assessment tool Molly Hastings, Sarah Moreland-Russell S61 A review of D&I study designs in published study protocols Rachel Tabak, Alex Ramsey, Ana Baumann, Emily Kryzer, Katherine Montgomery, Ericka Lewis, Margaret Padek, Byron Powell, Ross Brownson S62 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Model simulation techniques to estimate the cost of implementing foundational public health services Cezar Brian Mamaril, Glen Mays, Keith Branham, Lava Timsina S63 PANEL: Geographic variation in the implementation of public health services: Economic, organizational, and network determinants - Inter-organizational network effects on the implementation of public health services Glen Mays, Rachel Hogg S64 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Implementation fidelity, coalition functioning, and community prevention system transformation using communities that care Abigail Fagan, Valerie Shapiro, Eric Brown S65 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Expanding capacity for implementation of communities that care at scale using a web-based, video-assisted training system Kevin Haggerty, David Hawkins S66 PANEL: Building capacity for implementation and dissemination of the communities that care prevention system at scale to promote evidence-based practices in behavioral health - Effects of communities that care on reducing youth behavioral health problems Sabrina Oesterle, David Hawkins, Richard Catalano S68 When interventions end: the dynamics of intervention de-adoption and replacement Virginia McKay, M. Margaret Dolcini, Lee Hoffer S69 Results from next-d: can a disease specific health plan reduce incident diabetes development among a national sample of working-age adults with pre-diabetes? Tannaz Moin, Jinnan Li, O. Kenrik Duru, Susan Ettner, Norman Turk, Charles Chan, Abigail Keckhafer, Robert Luchs, Sam Ho, Carol Mangione S70 Implementing smoking cessation interventions in primary care settings (STOP): using the interactive systems framework Peter Selby, Laurie Zawertailo, Nadia Minian, Dolly Balliunas, Rosa Dragonetti, Sarwar Hussain, Julia Lecce S71 Testing the Getting To Outcomes implementation support intervention in prevention-oriented, community-based settings Matthew Chinman, Joie Acosta, Patricia Ebener, Patrick S Malone, Mary Slaughter S72 Examining the reach of a multi-component farmers’ market implementation approach among low-income consumers in an urban context Darcy Freedman, Susan Flocke, Eunlye Lee, Kristen Matlack, Erika Trapl, Punam Ohri-Vachaspati, Morgan Taggart, Elaine Borawski S73 Increasing implementation of evidence-based health promotion practices at large workplaces: The CEOs Challenge Amanda Parrish, Jeffrey Harris, Marlana Kohn, Kristen Hammerback, Becca McMillan, Peggy Hannon S74 A qualitative assessment of barriers to nutrition promotion and obesity prevention in childcare Taren Swindle, Geoffrey Curran, Leanne Whiteside-Mansell, Wendy Ward S75 Documenting institutionalization of a health communication intervention in African American churches Cheryl Holt, Sheri Lou Santos, Erin Tagai, Mary Ann Scheirer, Roxanne Carter, Janice Bowie, Muhiuddin Haider, Jimmie Slade, Min Qi Wang S76 Reduction in hospital utilization by underserved patients through use of a community-medical home Andrew Masica, Gerald Ogola, Candice Berryman, Kathleen Richter S77 Sustainability of evidence-based lay health advisor programs in African American communities: A mixed methods investigation of the National Witness Project Rachel Shelton, Lina Jandorf, Deborah Erwin S78 Predicting the long-term uninsured population and analyzing their gaps in physical access to healthcare in South Carolina Khoa Truong S79 Using an evidence-based parenting intervention in churches to prevent behavioral problems among Filipino youth: A randomized pilot study Joyce R. Javier, Dean Coffey, Sheree M. Schrager, Lawrence Palinkas, Jeanne Miranda S80 Sustainability of elementary school-based health centers in three health-disparate southern communities Veda Johnson, Valerie Hutcherson, Ruth Ellis S81 Childhood obesity prevention partnership in Louisville: creative opportunities to engage families in a multifaceted approach to obesity prevention Anna Kharmats, Sandra Marshall-King, Monica LaPradd, Fannie Fonseca-Becker S82 Improvements in cervical cancer prevention found after implementation of evidence-based Latina prevention care management program Deanna Kepka, Julia Bodson, Echo Warner, Brynn Fowler S83 The OneFlorida data trust: Achieving health equity through research & training capacity building Elizabeth Shenkman, William Hogan, Folakami Odedina, Jessica De Leon, Monica Hooper, Olveen Carrasquillo, Renee Reams, Myra Hurt, Steven Smith, Jose Szapocznik, David Nelson, Prabir Mandal S84 Disseminating and sustaining medical-legal partnerships: Shared value and social return on investment James Teufel FAU - Chambers, David AU - Chambers D AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD 20850 USA FAU - Simpson, Lisa AU - Simpson L AD - AcademyHealth, Washington, DC 20036 USA FAU - Hill-Briggs, Felicia AU - Hill-Briggs F AD - Department of Medicine and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287 USA FAU - Neta, Gila AU - Neta G AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD 20850 USA FAU - Vinson, Cynthia AU - Vinson C AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD 20850 USA FAU - Chambers, David AU - Chambers D AD - Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD 20850 USA FAU - Beidas, Rinad AU - Beidas R AD - Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 USA AD - Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Marcus, Steven AU - Marcus S AD - School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA 19103 USA FAU - Aarons, Gregory AU - Aarons G AD - Psychiatry, UC San Diego, La Jolla, CA 92083-0812 USA FAU - Hoagwood, Kimberly AU - Hoagwood K AD - Child & Adolescent Psychiatry, The Child Study Center at NYU Langone Medical Center, New York, NY, New York, NY 10016 USA FAU - Schoenwald, Sonja AU - Schoenwald S AD - Psychiatry and Behavioral Sciences, MUSC, Charleston, SC 29425 USA FAU - Evans, Arthur AU - Evans A AD - DBHIDS, City of Philadelphia, Philadelphia, PA 19104 USA FAU - Hurford, Matthew AU - Hurford M AD - DBHIDS, City of Philadelphia, Philadelphia, PA 19104 USA FAU - Rubin, Ronnie AU - Rubin R AD - CBH, City of Philadelphia, Philadelphia, PA 19104 USA FAU - Hadley, Trevor AU - Hadley T AD - Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Barg, Frances AU - Barg F AD - Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19107 USA FAU - Walsh, Lucia AU - Walsh L FAU - Adams, Danielle AU - Adams D AD - Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Mandell, David AU - Mandell D FAU - Martin, Lindsey AU - Martin L AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - Mignogna, Joseph AU - Mignogna J AD - Treatment Core, Department of Veterans Affairs, Waco, TX 76711 USA FAU - Mott, Juliette AU - Mott J AD - National Center for PTSD, Executive Division, Department of Veterans Affairs, White River Junction, VT 05009 USA FAU - Hundt, Natalie AU - Hundt N AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - Kauth, Michael AU - Kauth M AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - Kunik, Mark AU - Kunik M AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - Naik, Aanand AU - Naik A AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - Cully, Jeffrey AU - Cully J AD - Health Services Research & Development, Department of Veterans Affairs & Baylor College of Medicine, Houston, TX 77030 USA FAU - McGuire, Alan AU - McGuire A AD - HSR&D, HSR&D Center for Health Information and Communication, Roudebush VA Medical Center, Indianapolis, IN 46202 USA AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA FAU - White, Dominique AU - White D AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA FAU - Bartholomew, Tom AU - Bartholomew T AD - Department of Psychiatric Rehabilitation and Counseling, Rutgers University, Newark, NJ 07107 USA FAU - McGrew, John AU - McGrew J AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA FAU - Luther, Lauren AU - Luther L AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA FAU - Rollins, Angie AU - Rollins A AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA AD - Health Services Research & Development, Richard L. Roudebush VAMC, Indianapolis, IN 46202 USA FAU - Salyers, Michelle AU - Salyers M AD - Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202 USA AD - IUPUI Department of Psychology, ACT Center of Indiana, Indianapolis, IN 46202 USA FAU - Cooper, Brittany AU - Cooper B AD - Human Development, Washington State University, Pullman, WA 99164 USA FAU - Funaiole, Angie AU - Funaiole A AD - Prevention Science, Washington State University, Pullman, WA 99164 USA FAU - Richards, Julie AU - Richards J AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - Lee, Amy AU - Lee A AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - Lapham, Gwen AU - Lapham G AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - Caldeiro, Ryan AU - Caldeiro R AD - Behavioral Health Services, Group Health, Seattle, WA 98101 USA FAU - Lozano, Paula AU - Lozano P AD - Preventive Care, Group Health, Seattle, WA 98101 USA FAU - Gildred, Tory AU - Gildred T AD - Behavioral Health Services, Group Health, Seattle, WA 98101 USA FAU - Achtmeyer, Carol AU - Achtmeyer C AD - Health Services Research & Development, Primary and Specialty Medical Care Service, VA Puget Sound, Seattle, WA 98108 USA FAU - Ludman, Evette AU - Ludman E AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - Addis, Megan AU - Addis M AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - Marx, Larry AU - Marx L AD - Behavioral Health Services, Group Health, Seattle, WA 98101 USA FAU - Bradley, Katharine AU - Bradley K AD - Group Health Research Institute, Group Health, Seattle, WA 98101 USA FAU - VanDeinse, Tonya AU - VanDeinse T AD - School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA FAU - Wilson, Amy Blank AU - Wilson AB AD - School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA FAU - Stacey, Burgin AU - Stacey B AD - School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA FAU - Powell, Byron AU - Powell B AD - Health Policy & Management, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27566-7411 USA FAU - Bunger, Alicia AU - Bunger A AD - College of Social Work, Ohio State University, Columbus, OH 43210 USA FAU - Cuddeback, Gary AU - Cuddeback G AD - School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA FAU - Barnett, Miya AU - Barnett M AD - Psychology, University of California, Los Angeles, Los Angeles, CA 90095 USA FAU - Stadnick, Nicole AU - Stadnick N AD - Psychiatry, University of California, San Diego, La Jolla, CA 92093 USA FAU - Brookman-Frazee, Lauren AU - Brookman-Frazee L AD - Psychiatry, University of California, San Diego, La Jolla, CA 92093 USA FAU - Lau, Anna AU - Lau A AD - Psychology, University of California, Los Angeles, Los Angeles, CA 90095 USA FAU - Dorsey, Shannon AU - Dorsey S AD - Psychology, University of Washington, Seattle, WA 98195 USA FAU - Pullmann, Michael AU - Pullmann M AD - Psychology, University of Washington, Seattle, WA 98195 USA AD - Department of Psychiatry and Behavioral Sciences, Division of Public Behavioral Health, University of Washington, Seattle, WA 98102 USA FAU - Mitchell, Shannon AU - Mitchell S AD - Social Research Center, Friends Research Institute, Baltimore, MD 21201 USA FAU - Schwartz, Robert AU - Schwartz R AD - Social Research Center, Friends Research Institute, Baltimore, MD 21201 USA FAU - Kirk, Arethusa AU - Kirk A AD - Pediatrics, Total Health Care, Baltimore, MD 21217 USA FAU - Dusek, Kristi AU - Dusek K AD - Social Research Center, Friends Research Institute, Baltimore, MD 21201 USA FAU - Oros, Marla AU - Oros M AD - The Mosaic Group, The Mosaic Group, Baltimore, MD 21210 USA FAU - Hosler, Colleen AU - Hosler C AD - The Mosaic Group, The Mosaic Group, Baltimore, MD 21210 USA FAU - Gryczynski, Jan AU - Gryczynski J AD - Social Research Center, Friends Research Institute, Baltimore, MD 21201 USA FAU - Barbosa, Carolina AU - Barbosa C AD - Behavioral Health Economics Program, RTI International, Chicago, IL 60606-4901 USA FAU - Dunlap, Laura AU - Dunlap L AD - Center for Interdisciplinary Substance Abuse Research, Research Triangle Institute, Rockville, MD 20852 USA FAU - Lounsbury, David AU - Lounsbury D AD - Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10467 USA AD - Division of Community Collaboration and Implementation Science, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY 10467 USA FAU - O’Grady, Kevin AU - O’Grady K AD - Department of Psychology, University of Maryland, College Park, College Park, MD 20742 USA FAU - Brown, Barry AU - Brown B AD - Psychology, University of North Carolina at Wilmington, Wilmington, NC 28403 USA FAU - Damschroder, Laura AU - Damschroder L AD - Department of Veterans Affairs, VA Center for Clinical Management Research, Ann Arbor, MI 48105 USA FAU - Waltz, Thomas AU - Waltz T AD - Department of Veterans Affairs, VA Center for Clinical Management Research, Ann Arbor, MI 48105 USA AD - Psychology, Eastern Michigan University, Ypsilanti, MI 48197 USA FAU - Powell, Byron AU - Powell B AD - Health Policy & Management, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27566 USA FAU - Ritchie, Mona AU - Ritchie M AD - VA QUERI Program for Team-Based Behavioral Health, Department of Veterans Affairs, North Little Rock, AR 72114 USA FAU - Waltz, Thomas AU - Waltz T AD - Psychology, Eastern Michigan University, Ypsilanti, MI 48197 USA AD - Health Services Research & Development, VA Center for Clinical Management Research, Ann Arbor, MI 48105 USA FAU - Atkins, David AU - Atkins D AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105 USA FAU - Imel, Zac E AU - Imel ZE AD - Educational Psychology, University of Utah, Salt Lake City, UT 84112 USA FAU - Xiao, Bo AU - Xiao B AD - Electrical Engineering, University of Southern California, Los Angeles, CA 90089 USA FAU - Can, Doğan AU - Can D AD - Computer Science, University of Southern California, Los Angeles, CA 90089 USA FAU - Georgiou, Panayiotis AU - Georgiou P AD - Electrical Engineering, University of Southern California, Los Angeles, CA 90089 USA FAU - Narayanan, Shrikanth AU - Narayanan S AD - Electrical Engineering & Computer Science, University of Southern California, Los Angeles, CA 90089 USA FAU - Berkel, Cady AU - Berkel C AD - REACH Institute, Arizona State University, Tempe, AZ 85284 USA FAU - Gallo, Carlos AU - Gallo C AD - Center for Prevention Implementation Methodology, Northwestern University, Chicago, IL 60611 USA FAU - Sandler, Irwin AU - Sandler I AD - REACH Institute, Arizona State University, Tempe, AZ 85284 USA FAU - Brown, C Hendricks AU - Brown CH AD - Center for Prevention Implementation Methodology, Northwestern University, Chicago, IL 60611 USA FAU - Wolchik, Sharlene AU - Wolchik S AD - REACH Institute, Arizona State University, Tempe, AZ 85284 USA FAU - Mauricio, Anne Marie AU - Mauricio AM AD - Psychology, Arizona State University, Tempe, AZ 85287 USA FAU - Gallo, Carlos AU - Gallo C AD - Center for Prevention Implementation Methodology, Northwestern University, Chicago, IL 60611 USA FAU - Brown, C Hendricks AU - Brown CH AD - Center for Prevention Implementation Methodology, Northwestern University, Chicago, IL 60611 USA FAU - Mehrotra, Sanjay AU - Mehrotra S AD - Industrial Engineering, Northwestern University, Chicago, IL 60611 USA FAU - Chandurkar, Dharmendra AU - Chandurkar D AD - Research, Sambodhi Research and Communications Private Limited, Noida, 201301 India FAU - Bora, Siddhartha AU - Bora S AD - Research, Sambodhi Research and Communications Private Limited, Noida, 201301 India FAU - Das, Arup AU - Das A AD - Monitoring and Evaluation, India Health Action Trust, Lucknow, 226001 India FAU - Tripathi, Anand AU - Tripathi A AD - Monitoring and Evaluation, India Health Action Trust, Lucknow, 226001 India FAU - Saggurti, Niranjan AU - Saggurti N AD - Monitoring, Learning and Evaluation, Bill and Melinda Gates Foundation, New Delhi, 110057 India FAU - Raj, Anita AU - Raj A AD - Division of Global Public Health, Department of Medicine, University of California, San Diego, San Diego, CA 92093 USA FAU - Hughes, Eric AU - Hughes E AD - Information Technology, MITRE, Bedford, MA 01730 USA FAU - Jacobs, Brian AU - Jacobs B AD - VP, CMIO, CIO, Children’s National Health System, Washington, DC, 20010 USA FAU - Kirkendall, Eric AU - Kirkendall E AD - Association CMIO, Cincinnati Children’s Hospital and Medical Center, Cincinnati, OH 45229 USA FAU - Loeb, Danielle AU - Loeb D AD - Department of Medicine/Division of General Internal Medicine, University of Colorado School of Medicine, Aurora, CO 80045 USA FAU - Trinkley, Katy AU - Trinkley K AD - Department of Clinical Pharmacy, University of Colorado School of Pharmacy, Aurora, CO 80045 USA FAU - Yang, Michael AU - Yang M AD - University of Colorado School of Medicine, Aurora, CO 80045 USA FAU - Sprowell, Andrew AU - Sprowell A AD - University of Colorado School of Medicine, Aurora, CO 80045 USA FAU - Nease, Donald AU - Nease D AD - Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO 80238 USA FAU - Lyon, Aaron AU - Lyon A AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Lewis, Cara AU - Lewis C AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Boyd, Meredith AU - Boyd M AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Melvin, Abigail AU - Melvin A AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Nicodimos, Semret AU - Nicodimos S AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Liu, Freda AU - Liu F AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Jungbluth, Nathanial AU - Jungbluth N AD - Psychology, University of Washington, Seattle, WA 98115 USA FAU - Lyon, Aaron AU - Lyon A AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Lewis, Cara AU - Lewis C AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Boyd, Meredith AU - Boyd M AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Melvin, Abigail AU - Melvin A AD - Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405 USA FAU - Nicodimos, Semret AU - Nicodimos S AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Liu, Freda AU - Liu F AD - Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98115 USA FAU - Jungbluth, Nathanial AU - Jungbluth N AD - Psychology, University of Washington, Seattle, WA 98115 USA FAU - Flynn, Allen AU - Flynn A AD - Learning Health Sciences, Medical School, University of Michigan, Ann Arbor, MI 48109 USA FAU - Landis-Lewis, Zach AU - Landis-Lewis Z AD - Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI 48109 USA FAU - Sales, Anne AU - Sales A AD - Learning Health Sciences, University of Michigan, Ann Arbor, MI 48109 USA AD - Center for Clinical Management Research, VA Ann Arbor Health Care System, Ann Arbor, MI 48109 USA FAU - Baloh, Jure AU - Baloh J AD - Department of Health Management and Policy, University of Iowa, Iowa City, IA 52242 USA FAU - Ward, Marcia AU - Ward M AD - Department of Health Management and Policy, University of Iowa, Iowa City, IA 52242 USA FAU - Zhu, Xi AU - Zhu X AD - Department of Health Management and Policy, University of Iowa, Iowa City, IA 52242 USA FAU - Bennett, Ian AU - Bennett I AD - Family Medicine, University of Washington, Seattle, WA 98105-6099 USA FAU - Unutzer, Jurgen AU - Unutzer J AD - Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195 USA FAU - Mao, Johnny AU - Mao J AD - Center for Clinical and Epidemiological Research, University of Washington, Seattle, WA 98101 USA FAU - Proctor, Enola AU - Proctor E AD - George Warren Brown School of Social Work, Washington University in St. Louis, Saint Louis, MO 63130 USA FAU - Vredevoogd, Mindy AU - Vredevoogd M AD - Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195 USA FAU - Chan, Ya-Fen AU - Chan YF AD - Psychiatry & Behavioral Sciences, University of Washington, Seattle, WA 98195 USA FAU - Williams, Nathaniel AU - Williams N AD - Social Work, Boise State University, Boise, ID 83725 USA FAU - Green, Phillip AU - Green P AD - School of Social Work, University of Tennessee, Knoxville, TN 37996 USA FAU - Bernstein, Steven AU - Bernstein S AD - Emergency Medicine, Yale University School of Medicine, New Haven, CT 06519 USA AD - Cancer Prevention and Control, Yale Cancer Center, New Haven, CT 06519 USA FAU - Rosner, June-Marie AU - Rosner JM AD - Emergency Medicine, Yale University School of Medicine, New Haven, CT 06519 USA FAU - DeWitt, Michelle AU - DeWitt M AD - Information Technology Services, Yale-New Haven Hospital, New Haven, CT 06510 USA FAU - Tetrault, Jeanette AU - Tetrault J AD - Medicine, Yale School of Medicine, New Haven, CT 06519 USA FAU - Dziura, James AU - Dziura J AD - Emergency Medicine, Yale University School of Medicine, New Haven, CT 06519 USA FAU - Hsiao, Allen AU - Hsiao A AD - Pediatrics and Emergency Medicine, Yale-New Haven Hospital, New Haven, CT 06510 USA FAU - Sussman, Scott AU - Sussman S AD - Medicine, Yale-New Haven Hospital, New Haven, CT 06510 USA FAU - O’Connor, Patrick AU - O’Connor P AD - Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 USA FAU - Toll, Benjamin AU - Toll B AD - Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425 USA FAU - Jones, Michael AU - Jones M AD - Research, Shepherd Center, Atlanta, GA 30312 USA FAU - Gassaway, Julie AU - Gassaway J AD - Virginia C. Crawford Research Institute, Atlanta, GA 30309 USA FAU - Tobin, Jonathan AU - Tobin J AD - Community Engaged Research, Clinical Directors Network, Inc. & The Rockefeller University, New York, NY 10018 USA FAU - Zatzick, Douglas AU - Zatzick D AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104 USA FAU - Bradbury, Angela R AU - Bradbury AR AD - Division of Hematology-Oncology, Department of Medicine, The University of Pennsylvania, Philadelphia, PA 19104 USA AD - Department of Medical Ethics and Health Policy, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Patrick-Miller, Linda AU - Patrick-Miller L AD - Center for Clinical Cancer Genetics Department of Medicine, Hematology/Oncology, The University of Chicago, Chicago, IL 60637 USA FAU - Egleston, Brian AU - Egleston B AD - Biostatistics and Bioinformatics Facility, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Olopade, Olufunmilayo I AU - Olopade OI AD - Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637 USA FAU - Hall, Michael J AU - Hall MJ AD - Clinical Genetics/Gastrointestinal Risk Assessment, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Daly, Mary B AU - Daly MB AD - Department of Clinical Genetics, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Fleisher, Linda AU - Fleisher L AD - Center for Injury Research and Prevention, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104 USA FAU - Grana, Generosa AU - Grana G AD - Hematology and Medical Oncology, MD Anderson Cancer Center at Cooper, Camden, NJ 08043 USA FAU - Ganschow, Pamela AU - Ganschow P AD - Internal Medicine, John H. Stroger, Jr. Hospital, Chicago, IL 60612 USA FAU - Fetzer, Dominique AU - Fetzer D AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Brandt, Amanda AU - Brandt A AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Farengo-Clark, Dana AU - Farengo-Clark D AD - Cancer Genetics Program, MD Anderson Cancer Center at Cooper, Camden, NJ 08043 USA FAU - Forman, Andrea AU - Forman A AD - Department of Clinical Genetics, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Gaber, Rikki S AU - Gaber RS AD - Breast and Cervical Cancer Screening Program, John H. Stroger, Jr. Hospital, Chicago, IL 60612 USA FAU - Gulden, Cassandra AU - Gulden C AD - Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637 USA FAU - Horte, Janice AU - Horte J AD - Cancer Genetics Program, MD Anderson Cancer Center at Cooper, Camden, NJ 08043 USA FAU - Long, Jessica AU - Long J AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Chambers, Rachelle Lorenz AU - Chambers RL AD - Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637 USA FAU - Lucas, Terra AU - Lucas T AD - Cancer Screening Program, John H. Stroger, Jr. Hospital, Chicago, IL 60612 USA FAU - Madaan, Shreshtha AU - Madaan S AD - Comprehensive Cancer Risk and Prevention Clinic, The University of Chicago, Chicago, IL 60637 USA FAU - Mattie, Kristin AU - Mattie K AD - Cancer Genetics Program, MD Anderson Cancer Center at Cooper, Camden, NJ 08043 USA FAU - McKenna, Danielle AU - McKenna D AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Montgomery, Susan AU - Montgomery S AD - Department of Clinical Genetics, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Nielsen, Sarah AU - Nielsen S AD - Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637 USA FAU - Powers, Jacquelyn AU - Powers J AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Rainey, Kim AU - Rainey K AD - Department of Clinical Genetics, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Rybak, Christina AU - Rybak C AD - Department of Clinical Genetics, The Fox Chase Cancer Center, Philadelphia, PA 19111 USA FAU - Savage, Michelle AU - Savage M AD - Emory Prevention Research Center, Emory University Rollins School of Public Health, Atlanta, GA 30322 USA FAU - Seelaus, Christina AU - Seelaus C AD - Breast and Cervical Cancer Screening Program, John H. Stroger, Jr. Hospital, Chicago, IL 60612 USA FAU - Stoll, Jessica AU - Stoll J AD - Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637 USA FAU - Stopfer, Jill AU - Stopfer J AD - Mariann and Robert MacDonald Women’s Cancer Risk Evaluation Program, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Yao, Shirley AU - Yao S AD - Breast and Cervical Cancer Screening Program, John H. Stroger, Jr. Hospital, Chicago, IL 60612 USA FAU - Domchek, Susan AU - Domchek S AD - Division of Hematology-Oncology, Department of Medicine, The University of Pennsylvania, Philadelphia, PA 19104 USA FAU - Hahn, Erin AU - Hahn E AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Munoz-Plaza, Corrine AU - Munoz-Plaza C AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Wang, Jianjin AU - Wang J AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Delgadillo, Jazmine Garcia AU - Delgadillo JG AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Mittman, Brian AU - Mittman B AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Gould, Michael AU - Gould M AD - Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA 91101 USA FAU - Liang, Shuting (Lily) AU - Liang S AD - Emory Prevention Research Center, Emory University Rollins School of Public Health, Atlanta, GA 30322 USA AD - Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94301 USA FAU - Kegler, Michelle C AU - Kegler MC AD - Emory Prevention Research Center, Emory University Rollins School of Public Health, Atlanta, GA 30322 USA AD - Department of Behavioral Sciences and Health Education, Emory University Rollins School of Public Health, Atlanta, GA 30322 USA FAU - Cotter, Megan AU - Cotter M AD - Behavioral Sciences and Health Education, Rollins School of Public Health, Emory Prevention Research Center, Atlanta, GA 30322 USA FAU - Phillips, Emily AU - Phillips E AD - Behavioral Sciences and Health Education, Rollins School of Public Health, Emory Prevention Research Center, Atlanta, GA 30322 USA FAU - Hermstad, April AU - Hermstad A AD - Behavioral Sciences and Health Education, Rollins School of Public Health, Emory Prevention Research Center, Atlanta, GA 30322 USA FAU - Morton, Rentonia AU - Morton R AD - Statistics and Evaluation Center, American Cancer Society, Atlanta, GA 30303 USA FAU - Beasley, Derrick AU - Beasley D AD - Behavioral Sciences and Health Education, Rollins School of Public Health, Emory Prevention Research Center, Atlanta, GA 30322 USA FAU - Martinez, Jeremy AU - Martinez J AD - Statistics and Evaluation Center, American Cancer Society, Atlanta, GA 30303 USA FAU - Riehman, Kara AU - Riehman K AD - Statistics and Evaluation Center, American Cancer Society, Atlanta, GA 30303 USA FAU - Gustafson, David AU - Gustafson D AD - Center for Health Enhancement Systems Studies, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - Marsch, Lisa AU - Marsch L AD - Center for Technology and Behavioral Health, Dartmouth College, Dartmouth, NH 03755 USA FAU - Mares, Louise AU - Mares L AD - Communication Arts, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - Quanbeck, Andrew AU - Quanbeck A AD - Industrial and Systems Engineering, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - McTavish, Fiona AU - McTavish F AD - Center for Health Enhancement Systems Studies, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - McDowell, Helene AU - McDowell H AD - Center for Health Enhancement Systems Studies, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - Brown, Randall AU - Brown R AD - Family Medicine, Population Health Sciences, University of Wisconsin School of Medicine & Public Health, Madison, WI 53715 USA FAU - Thomas, Chantelle AU - Thomas C AD - Access Community Health Center, Access Community Health Center, Madison, WI 53706 USA FAU - Glass, Joseph AU - Glass J AD - School of Social Work, University of Wisconsin – Madison, Madison, WI 54706 USA FAU - Isham, Joseph AU - Isham J AD - Center for Health Enhancement Systems Studies, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - Shah, Dhavan AU - Shah D AD - Communication Sciences, University of Wisconsin – Madison, Madison, WI 53706 USA FAU - Liebschutz, Jane AU - Liebschutz J AD - Clinical Addiction Research and Education (CARE) Unit, Boston Medical Center/Boston University School of Medicine, Boston, MA 02118 USA FAU - Lasser, Karen AU - Lasser K AD - Clinical Addiction Research and Education (CARE) Unit, Boston Medical Center/Boston University School of Medicine, Boston, MA 02118 USA AD - Boston University School of Public Health, Boston, MA 02118 USA FAU - Watkins, Katherine AU - Watkins K AD - RAND Corporation, RAND Corporation, Santa Monica, CA 90407 USA FAU - Ober, Allison AU - Ober A AD - RAND Corporation, RAND Corporation, Santa Monica, CA 90407 USA FAU - Hunter, Sarah AU - Hunter S AD - RAND Corporation, RAND Corporation, Santa Monica, CA 90407 USA FAU - Lamp, Karen AU - Lamp K AD - Venice Family Clinic, Venice Family Clinic, Venice, CA 90291 USA FAU - Ewing, Brett AU - Ewing B AD - RAND Corporation, RAND Corporation, Santa Monica, CA 90407 USA FAU - Iwelunmor, Juliet AU - Iwelunmor J AD - Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61822 USA FAU - Gyamfi, Joyce AU - Gyamfi J AD - Center for Healthful Behavior Change, New York University, New York, NY 10016 USA FAU - Blackstone, Sarah AU - Blackstone S AD - Kinesiology and Community Health, University of Illinois at Urbana Champaign, Champaign, IL 61822 USA FAU - Quakyi, Nana Kofi AU - Quakyi NK AD - Global Institute of Public Health, New York University, New York, NY 10003 USA FAU - Plange-Rhule, Jacob AU - Plange-Rhule J AD - Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, 00000 Ghana FAU - Ogedegbe, Gbenga AU - Ogedegbe G AD - Center for Healthful Behavior Change, New York University, New York, NY 10016 USA AD - Population Health and Medicine, New York University, New York, NY 10016 USA FAU - Kumar, Pritika AU - Kumar P AD - Department of Population Health, New York University School of Medicine, New York, NY 10016 USA FAU - Van Devanter, Nancy AU - Van Devanter N AD - College of Nursing, New York University, New York, NY 10075 USA FAU - Nguyen, Nam AU - Nguyen N AD - Institute of Social and Medical Sciences, Institute of Social and Medical Sciences, Hanoi, Vietnam FAU - Nguyen, Linh AU - Nguyen L AD - Institute of Social and Medical Sciences, Institute of Social and Medical Sciences, Hanoi, Vietnam FAU - Nguyen, Trang AU - Nguyen T AD - Institute of Social and Medical Sciences, Institute of Social and Medical Sciences, Hanoi, Vietnam FAU - Phuong, Nguyet AU - Phuong N AD - Institute of Social and Medical Sciences, Institute of Social and Medical Sciences, Hanoi, Vietnam FAU - Shelley, Donna AU - Shelley D AD - Department of Population Health, New York University School of Medicine, New York, NY 10016 USA FAU - Rudge, Sian AU - Rudge S AD - Knowledge Exchange Division, Sax Institute, Ultimo, NSW 2007 Australia FAU - Langlois, Etienne AU - Langlois E AD - Alliance for Health Policy and Systems Research, World Health Organization, Geneva, 1211 Switzerland FAU - Tricco, Andrea AU - Tricco A AD - Dalla Lana School of Public Health/St Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8 Canada FAU - Ball, Sherry AU - Ball S AD - Research, Department of Veterans Affairs, Cleveland, OH 44106 USA FAU - Lambert-Kerzner, Anne AU - Lambert-Kerzner A AD - Research, Eastern Colorado Health Care System, Department of Veterans Affairs, Denver, CO 80220 USA AD - University of Colorado, Denver, CO 80204 USA FAU - Sulc, Christine AU - Sulc C AD - Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, WA 98108 USA FAU - Simmons, Carol AU - Simmons C AD - Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, WA 98108 USA FAU - Shell-Boyd, Jeneen AU - Shell-Boyd J AD - Research Service, Cleveland VA Medical Center, Cleveland, OH 44106 USA FAU - Oestreich, Taryn AU - Oestreich T AD - Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, WA 98108 USA FAU - O’Connor, Ashley AU - O’Connor A AD - Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, WA 98108 USA FAU - Neely, Emily AU - Neely E AD - Center of Innovation for Veteran-Centered and Value-Driven Care, VA Puget Sound Health Care System, Seattle, WA 98108 USA FAU - McCreight, Marina AU - McCreight M AD - Research, Eastern Colorado Health Care System, Department of Veterans Affairs, Denver, CO 80220 USA FAU - Labebue, Amy AU - Labebue A AD - Denver-Seattle Center of Innovation, Eastern Colorado Health Care System, Aurora, CO 80045 USA FAU - DiFiore, Doreen AU - DiFiore D AD - Research, Cleveland VA Medical Center, Cleveland, OH 44106 USA FAU - Brostow, Diana AU - Brostow D AD - Denver-Seattle Center of Innovation, VA Eastern Colorado Health Care System, Denver, CO 80220 USA FAU - Ho, P Michael AU - Ho PM AD - Research, Eastern Colorado Health Care System, Department of Veterans Affairs, Denver, CO 80220 USA AD - University of Colorado, Denver, CO 80204 USA FAU - Aron, David AU - Aron D AD - Education Department, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106 USA AD - Medicine, Case Western Reserve University School of Medicine, Cleveland, OH USA FAU - Harvey, Jillian AU - Harvey J AD - Health Professions, Medical University of South Carolina, Charleston, SC 29425 USA AD - Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC 29425 USA FAU - McHugh, Megan AU - McHugh M AD - Center for Healthcare Studies, Northwestern University, Chicago, IL 60611 USA FAU - Scanlon, Dennis AU - Scanlon D AD - Department of Health Policy and Administration, Pennsylvania State University, University Park, PA 16802 USA FAU - Lee, Rebecca AU - Lee R AD - College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004 USA FAU - Soltero, Erica AU - Soltero E AD - Health & Human Performance, University of Houston, Houston, TX 77204 USA FAU - Parker, Nathan AU - Parker N AD - Health & Human Performance, University of Houston, Houston, TX 77204 USA FAU - McNeill, Lorna AU - McNeill L AD - Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA FAU - Ledoux, Tracey AU - Ledoux T AD - Health & Human Performance, University of Houston, Houston, TX 77204 USA FAU - McIsaac, Jessie-Lee AU - McIsaac JL AD - School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2 Canada FAU - MacLeod, Kate AU - MacLeod K AD - School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2 Canada FAU - Ata, Nicole AU - Ata N AD - School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2 Canada FAU - Jarvis, Sherry AU - Jarvis S AD - School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2 Canada FAU - Kirk, Sara AU - Kirk S AD - School of Health and Human Performance, Dalhousie University, Halifax, NS B3H4R2 Canada FAU - Purtle, Jonathan AU - Purtle J AD - Health Management &Policy, Drexel University School of Public Health, Philadelphia, PA 19130 USA FAU - Dodson, Elizabeth AU - Dodson E AD - Institute for Public Health, Washington University, St. Louis, MO 63112 USA FAU - Brownson, Ross AU - Brownson R AD - Brown School and Prevention Research Center in St. Louis, Washington University in St. Louis, Saint Louis, MO 63130 USA FAU - Mittman, Brian AU - Mittman B AD - Research and Evaluation, Kaiser Permanente Southern Calif/US Dept of Veterans Affairs, Pasadena, CA 91101 USA FAU - Curran, Geoffrey AU - Curran G AD - Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Curran, Geoffrey AU - Curran G AD - Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Pyne, Jeffrey AU - Pyne J AD - Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Aarons, Gregory AU - Aarons G AD - Psychiatry, UC San Diego, La Jolla, CA 92083-0812 USA FAU - Ehrhart, Mark AU - Ehrhart M AD - Department of Psychology, San Diego State University, San Diego, CA 92182-4611 USA FAU - Torres, Elisa AU - Torres E AD - Psychiatry, UC San Diego, La Jolla, CA 92083-0812 USA FAU - Miech, Edward AU - Miech E AD - HSR&D, Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202 USA FAU - Miech, Edward AU - Miech E AD - HSR&D, Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202 USA FAU - Stevens, Kathleen AU - Stevens K AD - Improvement Science Research Network, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 USA CN - I.S.R.N. Steering Council AD - Improvement Science Research Network, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 USA FAU - Hamilton, Alison AU - Hamilton A AD - HSR&D Center for the Study of Healthcare Innovation, Implementation and Policy, Department of Veterans Affairs, Los Angeles, CA 90073 USA AD - UCLA Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90024 USA FAU - Cohen, Deborah AU - Cohen D AD - Family Medicine, Oregon Health & Science University, Portland, OR 97239 USA FAU - Padgett, Deborah AU - Padgett D AD - Silver School of Social Work, New York University, New York, NY 10003 USA FAU - Morshed, Alexandra AU - Morshed A AD - Brown School, Washington University in St. Louis, Saint Louis, MO 63130 USA FAU - Patel, Rupa AU - Patel R AD - Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO 63110 USA FAU - Prusaczyk, Beth AU - Prusaczyk B AD - Brown School, Washington University in St. Louis, Saint Louis, MO 63110 USA FAU - Aron, David C AU - Aron DC AD - Case Western Reserve University, Cleveland, OH USA AD - Department of Veterans Affairs, Medicine, Louis Stokes Cleveland Medical Center, Cleveland, OH 44106 USA FAU - Gupta, Divya AU - Gupta D AD - Research, Cleveland VA Medical Center, Cleveland, OH 44106 USA FAU - Ball, Sherry AU - Ball S AD - Research, Department of Veterans Affairs, Cleveland, OH 44106 USA FAU - Hand, Rosa AU - Hand R AD - Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL 60606 USA FAU - Abram, Jenica AU - Abram J AD - Research, International, and Scientific Affairs, Academy of Nutrition and Dietetics, Chicago, IL 60606 USA FAU - Wolfram, Taylor AU - Wolfram T AD - Web Strategy, Academy of Nutrition and Dietetics, Chicago, IL 60606 USA FAU - Hastings, Molly AU - Hastings M AD - Center for Public Health Systems Science, Washington University in St. Louis, St. Louis, MO 63112 USA FAU - Moreland-Russell, Sarah AU - Moreland-Russell S AD - Center for Public Health Systems Science, Washington University in St. Louis, St. Louis, MO 63112 USA FAU - Tabak, Rachel AU - Tabak R AD - Brown School and Prevention Research Center in St. Louis, Washington University in St. Louis, Saint Louis, MO 63130 USA FAU - Ramsey, Alex AU - Ramsey A AD - School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Baumann, Ana AU - Baumann A AD - Brown School, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Kryzer, Emily AU - Kryzer E AD - Brown School, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Montgomery, Katherine AU - Montgomery K AD - Brown School, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Lewis, Ericka AU - Lewis E AD - Brown School, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Padek, Margaret AU - Padek M AD - Brown School and Prevention Research Center in St. Louis, Washington University in St. Louis, Saint Louis, MO 63130 USA FAU - Powell, Byron AU - Powell B AD - Health Policy & Management, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27566-7411 USA FAU - Brownson, Ross AU - Brownson R AD - Brown School and Prevention Research Center in St. Louis, Washington University in St. Louis, Saint Louis, MO 63130 USA AD - School of Medicine, Washington University in St. Louis, St. Louis, MO 63110 USA FAU - Mamaril, Cezar Brian AU - Mamaril CB AD - Health Management and Policy, University of Kentucky, College of Public Health, Lexington, KY 40536 USA FAU - Mays, Glen AU - Mays G AD - Department of Health Services Management, University of Kentucky, College of Public Health, Lexington, KY 40536 USA FAU - Branham, Keith AU - Branham K AD - Health Management and Policy, University of Kentucky, College of Public Health, Lexington, KY 40536 USA FAU - Timsina, Lava AU - Timsina L AD - Systems for Action National Program Office, University of Kentucky, College of Public Health, Lexington, KY 40536 USA FAU - Mays, Glen AU - Mays G AD - Department of Health Services Management, University of Kentucky, College of Public Health, Lexington, KY 40536 USA FAU - Hogg, Rachel AU - Hogg R AD - College of Health Sciences, University of Kentucky, Lexington, KY 40536 USA FAU - Fagan, Abigail AU - Fagan A AD - Department of Sociology and Criminology & Law, University of Florida, Gainesville, FL 32611 USA FAU - Shapiro, Valerie AU - Shapiro V AD - School of Social Welfare, UC Berkeley, Berkeley, CA 94720 USA FAU - Brown, Eric AU - Brown E AD - Department of Public Health Sciences, University of Miami, Miami, FL 33136 USA FAU - Haggerty, Kevin AU - Haggerty K AD - School of Social Work, University of Washington, Seattle, WA 98115 USA FAU - Hawkins, David AU - Hawkins D AD - School of Social Work, University of Washington, Seattle, WA 98115 USA FAU - Oesterle, Sabrina AU - Oesterle S AD - School of Social Work, University of Washington, Seattle, WA 98115 USA FAU - Hawkins, David AU - Hawkins D AD - School of Social Work, University of Washington, Seattle, WA 98115 USA FAU - Catalano, Richard AU - Catalano R AD - School of Social Work, University of Washington, Seattle, WA 98115 USA FAU - McKay, Virginia AU - McKay V AD - College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331 USA FAU - Dolcini, M Margaret AU - Dolcini MM AD - School of Social and Behavioral Health Sciences, Oregon State University, Corvallis, OR 97331 USA FAU - Hoffer, Lee AU - Hoffer L AD - Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Moin, Tannaz AU - Moin T AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA AD - HSR&D Center for the Study of Healthcare Innovation, Implementation, and Policy, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073 USA FAU - Li, Jinnan AU - Li J AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA FAU - Duru, O Kenrik AU - Duru OK AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA FAU - Ettner, Susan AU - Ettner S AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA AD - Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles, CA 90095 USA FAU - Turk, Norman AU - Turk N AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA FAU - Chan, Charles AU - Chan C AD - Actuarial Pricing, UnitedHealthcare, Minneapolis, MN 55343 USA FAU - Keckhafer, Abigail AU - Keckhafer A AD - Actuarial Pricing, UnitedHealthcare, Minneapolis, MN 55369 USA FAU - Luchs, Robert AU - Luchs R AD - Actuarial Pricing, UnitedHealthcare, Minneapolis, MN 55343 USA FAU - Ho, Sam AU - Ho S AD - Innovations, UnitedHealthcare, Minneapolis, MN 55343 USA FAU - Mangione, Carol AU - Mangione C AD - Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at University of California, Los Angeles, CA 90024 USA FAU - Selby, Peter AU - Selby P AD - Addictions Program, Centre for Addiction and Mental Health, Toronto, ON M5T1P7 Canada AD - Family and Community Medicine, University of Toronto, Toronto, ON M5T1P7 Canada AD - Psychiatry, Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T1P7 Canada FAU - Zawertailo, Laurie AU - Zawertailo L AD - Addictions Program, Centre for Addiction and Mental Health, Toronto, ON M5T1P7 Canada AD - Pharmacology and Toxicology, University of Toronto, Toronto, ON M5T1P7 Canada FAU - Minian, Nadia AU - Minian N AD - Addictions Medicine, Centre for Addiction and Mental Health, Toronto, ON M5S 3E3 Canada FAU - Balliunas, Dolly AU - Balliunas D AD - Nicotine Dependence Service, Centre for Addiction and Mental Health, Toronto, ON M5T 1P7 Canada FAU - Dragonetti, Rosa AU - Dragonetti R AD - Addictions Medicine, Centre for Addiction and Mental Health, Toronto, ON M5S 3E3 Canada FAU - Hussain, Sarwar AU - Hussain S AD - Nicotine Dependence Service, Centre for Addiction and Mental Health, Toronto, ON M5T 1P7 Canada FAU - Lecce, Julia AU - Lecce J AD - Nicotine Dependence Service, Centre for Addiction and Mental Health, Toronto, ON M5T 1P7 Canada FAU - Chinman, Matthew AU - Chinman M AD - Health, RAND Corporation, Pittsburgh, PA 15213 USA AD - VISN 4 MIRECC, VA Pittsburgh Healthcare Center, Pittsburgh, PA 15206 USA FAU - Acosta, Joie AU - Acosta J AD - Health, RAND Corporation, Arlington, VA 22202-5050 USA FAU - Ebener, Patricia AU - Ebener P AD - Health, RAND Corporation, Santa Monica, CA 90407 USA FAU - Malone, Patrick S AU - Malone PS AD - Health, RAND Corporation, Pittsburgh, PA 15213 USA FAU - Slaughter, Mary AU - Slaughter M AD - Health, RAND Corporation, Pittsburgh, PA 15213 USA FAU - Freedman, Darcy AU - Freedman D AD - Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106 USA AD - Prevention Research Center for Healthy Neighborhoods, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Flocke, Susan AU - Flocke S AD - Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106 USA AD - Family Medicine, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Lee, Eunlye AU - Lee E AD - Mandel School of Applied Social Sciences, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Matlack, Kristen AU - Matlack K AD - Prevention Research Center for Healthy Neighborhoods, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Trapl, Erika AU - Trapl E AD - Prevention Research Center for Healthy Neighborhoods, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Ohri-Vachaspati, Punam AU - Ohri-Vachaspati P AD - School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ 85004 USA FAU - Taggart, Morgan AU - Taggart M AD - Agreculture, St. Clair Superior Development Corporation, Cleveland, OH 44103 USA FAU - Borawski, Elaine AU - Borawski E AD - Prevention Research Center for Healthy Neighborhoods, Case Western Reserve University, Cleveland, OH 44106 USA FAU - Parrish, Amanda AU - Parrish A AD - Department of Health Services, University of Washington, Health Promotion Research Center, Seattle, WA 98105 USA FAU - Harris, Jeffrey AU - Harris J AD - Health Promotion Research Center, University of Washington, Seattle, WA 98105 USA FAU - Kohn, Marlana AU - Kohn M AD - Department of Health Services, University of Washington, Health Promotion Research Center, Seattle, WA 98105 USA FAU - Hammerback, Kristen AU - Hammerback K AD - Department of Health Services, University of Washington, Health Promotion Research Center, Seattle, WA 98105 USA FAU - McMillan, Becca AU - McMillan B AD - Partner Relationships, American Cancer Society, Seattle, WA 98109 USA FAU - Hannon, Peggy AU - Hannon P AD - Health Services, University of Washington, Seattle, WA 98105 USA FAU - Swindle, Taren AU - Swindle T AD - Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Curran, Geoffrey AU - Curran G AD - Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Whiteside-Mansell, Leanne AU - Whiteside-Mansell L AD - Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Ward, Wendy AU - Ward W AD - Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 USA FAU - Holt, Cheryl AU - Holt C AD - Behavioral and Community Health, University of Maryland, College Park, MD 20742 USA FAU - Santos, Sheri Lou AU - Santos SL AD - Behavioral and Community Health, University of Maryland, College Park, MD 20742 USA FAU - Tagai, Erin AU - Tagai E AD - Behavioral and Community Health, University of Maryland, College Park, MD 20742 USA FAU - Scheirer, Mary Ann AU - Scheirer MA AD - Program Evaluation, Scheirer Consulting, Princeton, NJ 8540 USA FAU - Carter, Roxanne AU - Carter R AD - Community Ministry of Prince George’s County, Upper Marlboro, MD 20772 USA FAU - Bowie, Janice AU - Bowie J AD - Health Behavior and Society, Johns Hopkins University, Baltimore, MD 21205 USA FAU - Haider, Muhiuddin AU - Haider M AD - Maryland Institute for Applied Environmental Health, University of Maryland, College Park, MD 20742 USA FAU - Slade, Jimmie AU - Slade J AD - Community Ministry of Prince George’s County, Upper Marlboro, MD 20772 USA FAU - Wang, Min Qi AU - Wang MQ AD - Behavioral and Community Health, University of Maryland, College Park, MD 20742 USA FAU - Masica, Andrew AU - Masica A AD - Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, TX 75206 USA FAU - Ogola, Gerald AU - Ogola G AD - Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, TX 75206 USA FAU - Berryman, Candice AU - Berryman C AD - Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, TX 75206 USA FAU - Richter, Kathleen AU - Richter K AD - Center for Clinical Effectiveness, Baylor Scott & White Health, Dallas, TX 75206 USA FAU - Shelton, Rachel AU - Shelton R AD - Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York, NY 10032 USA FAU - Jandorf, Lina AU - Jandorf L AD - Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029 USA FAU - Erwin, Deborah AU - Erwin D AD - Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263 USA FAU - Truong, Khoa AU - Truong K AD - Public Health Sciences, Clemson University, Clemson, SC 29634 USA FAU - Javier, Joyce R AU - Javier JR AD - Department of Pediatrics, Division of General Pediatrics, Chidren’s Hospital Los Angeles/USC Keck School of Medicine, Los Angeles, CA 90027 USA FAU - Coffey, Dean AU - Coffey D AD - Department of Pediatrics, Division of General Pediatrics, Chidren’s Hospital Los Angeles/USC Keck School of Medicine, Los Angeles, CA 90027 USA FAU - Schrager, Sheree M AU - Schrager SM AD - Division of Hospital Medicine, Chidren’s Hospital Los Angeles, Los Angeles, CA 90027 USA FAU - Palinkas, Lawrence AU - Palinkas L AD - Social Work, University of Southern California, Los Angeles, CA 90089-0411 USA FAU - Miranda, Jeanne AU - Miranda J AD - Semel Institute for Neuroscience and Human Behavior, UCLA Center for Health Services and Society, Los Angeles, CA 90024 USA FAU - Johnson, Veda AU - Johnson V AD - Pediatrics, Emory University, Atlanta, GA 30303 USA AD - Pediatrics, PARTNERS for Equity in Child and Adolescent Health, Atlanta, GA 30303 USA FAU - Hutcherson, Valerie AU - Hutcherson V AD - Johns Creek, GA 30022 USA FAU - Ellis, Ruth AU - Ellis R AD - Pediatrics, Emory University, Atlanta, GA 30303 USA FAU - Kharmats, Anna AU - Kharmats A AD - International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205 USA AD - International Health, Global Obesity Prevention Center, Baltimore, MD 21205 USA FAU - Marshall-King, Sandra AU - Marshall-King S AD - Shawnee Christian Health Care Center, Louisville, KY 40212 USA FAU - LaPradd, Monica AU - LaPradd M AD - Shawnee Christian Health Care Center, Louisville, KY 40212 USA FAU - Fonseca-Becker, Fannie AU - Fonseca-Becker F AD - Health, Behavior, & Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21202 USA FAU - Kepka, Deanna AU - Kepka D AD - Huntsman Cancer Institute, University of Utah, College of Nursing and Huntsman Cancer Institute, Salt Lake City, UT 84112 USA FAU - Bodson, Julia AU - Bodson J AD - Cancer Control and Population Sciences, Huntsman Cancer Institute & University of Utah, Salt Lake City, UT 84112 USA FAU - Warner, Echo AU - Warner E AD - Cancer Control and Population Sciences, Huntsman Cancer Institute & University of Utah, Salt Lake City, UT 84112 USA FAU - Fowler, Brynn AU - Fowler B AD - Cancer Control and Population Sciences, Huntsman Cancer Institute & University of Utah, Salt Lake City, UT 84112 USA FAU - Shenkman, Elizabeth AU - Shenkman E AD - Department of Health Outcomes and Policy, University of Florida College of Medicine, Gainesville, FL 32606 USA FAU - Hogan, William AU - Hogan W AD - Department of Health Outcomes and Policy, University of Florida College of Medicine, Gainesville, FL 32606 USA FAU - Odedina, Folakami AU - Odedina F AD - Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL 32606 USA FAU - De Leon, Jessica AU - De Leon J AD - Clinical and Translational Science Institute, Florida State University College of Medicine, Tallahassee, FL 32308 USA FAU - Hooper, Monica AU - Hooper M AD - Psychology, University of Miami, Miami, FL 33136 USA FAU - Carrasquillo, Olveen AU - Carrasquillo O AD - Department of Medicine, University of Miami, Miami, FL 33136 USA FAU - Reams, Renee AU - Reams R AD - Department of Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL 32308 USA FAU - Hurt, Myra AU - Hurt M AD - College of Medicine, Florida State University, Tallahassee, FL 32308 USA FAU - Smith, Steven AU - Smith S AD - Translational Research Institute, Florida Hospital, Orlando, FL 32804 USA FAU - Szapocznik, Jose AU - Szapocznik J AD - Clinical and Translational Science Institute, University of Miami, Miami, FL 33136 USA FAU - Nelson, David AU - Nelson D AD - Clinical and Translational Science Institute, University of Florida, Gainesville, FL 32606 USA FAU - Mandal, Prabir AU - Mandal P AD - Biology, Edward Waters College, Jacksonville, FL 32309 USA FAU - Teufel, James AU - Teufel J AD - Public Health, Mercyhurst University, Erie, PA 16504 USA LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20160801 PL - England TA - Implement Sci JT - Implementation science : IS JID - 101258411 SB - IM PMC - PMC4977475 EDAT- 2016/08/05 06:00 MHDA- 2016/08/05 06:01 PMCR- 2016/08/01 CRDT- 2016/08/05 06:00 PHST- 2016/08/05 06:00 [entrez] PHST- 2016/08/05 06:00 [pubmed] PHST- 2016/08/05 06:01 [medline] PHST- 2016/08/01 00:00 [pmc-release] AID - 10.1186/s13012-016-0452-0 [pii] AID - 452 [pii] AID - 10.1186/s13012-016-0452-0 [doi] PST - epublish SO - Implement Sci. 2016 Aug 1;11 Suppl 2(Suppl 2):100. doi: 10.1186/s13012-016-0452-0. PMID- 31331561 OWN - NLM STAT- MEDLINE DCOM- 20191230 LR - 20191230 IS - 1873-6963 (Electronic) IS - 0965-2299 (Linking) VI - 45 DP - 2019 Aug TI - Delivery of patient-centered care in complementary medicine: Insights and evidence from the Chinese medical practitioners and patients in primary care consultations in Hong Kong. PG - 198-204 LID - S0965-2299(19)30303-6 [pii] LID - 10.1016/j.ctim.2019.06.013 [doi] AB - INTRODUCTION: Traditional Chinese Medicine (TCM) has become increasingly popular around the world, and has been accepted by people not only in China and Southeast Asia, but also in Western countries. Despite its historic role in the Chinese society, there has been limited research on exploring the nature of TCM practitioner-patient interactions in the Chinese context. As indicated by a major study regarding the Hong Kong context(1), there is a need to investigate the role of TCM practitioner and promote interdisciplinary research to ensure safety and synergy of TCM and Western medicine in primary care. This study aims to address this gap by investigating the nature of TCM consultations and their communication patterns in Hong Kong. METHODS: Based on 10 h of conversations (in Cantonese) between TCM practitioners and their patients in the diagnostic interviews, the study explored how the doctor-patient relationship was negotiated in the course of the consultation, while both the TCM practitioners and the patients were constantly trying to manage and maintain common ground. Particular attention had been paid to the identification of specific linguistic and discourse strategies that TCM practitioners had employed to establish doctor-patient rapport, so that a better understanding of patient-centred care in the TCM context could be obtained. The participants were recruited from a local university operated clinic which shared the characteristic of TCM practitioners in Hong Kong. RESULTS: A range of linguistic strategies that TCM practitioners used to deliver patient-centred care have been identified. These strategies are also helpful in shaping a joint decision-making process that will lead to better patient understanding and compliance with the doctors' treatments. CONCLUSIONS: This study demonstrates empirically how TCM practitioners utilize a range of linguistic resources and communication strategies to shape the ongoing discourse so that their patients can have a better understanding of their illnesses. For an example, it is found that TCM practitioners and their patients were constantly trying to manage and maintain common ground by using a range of grammatical markers, including sentence-final particles (SFPs) and discourse markers (DMs), to negotiate the epistemic commitment so that the patient would have good compliance with the practitioner's suggested treatment. It is also observed that various types of interrogatives have been used by the TCM practitioners to elicit information from the patients as well as to encourage them to talk and make a response. Furthermore, it is found that TCM practitioners would deliberately enquire about the patients' everyday experiences because what they eat, do, and encounter all have an important impact on their body conditions. By exploring into the patients' daily routines in the social talk, the practitioner can help maintain and promote the overall balance of the patient's body, and help them monitor and enhance their health conditions by modifying their daily habits and behaviours. With the adoption of these linguistic and communication strategies, the TCM practitioners are shown to have placed the patients' needs as their top priority. Previous studies in the field have already proved that co-construction of the treatment plan between the doctor and the patient is extremely important, and that a patient-centred approach can largely reduce adverse events leading to avoidable patient harm. The specific strategies identified in the current study can enhance the TCM practitioners' communication with patients, creating an environment that will surely optimise safety for both patients and clinicians. CI - Copyright © 2019 Elsevier Ltd. All rights reserved. FAU - Pun, Jack AU - Pun J AD - Department of English, The City University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address: jack.pun@cityu.edu.hk. FAU - Chor, Winnie AU - Chor W AD - Department of English Language and Literature, Hong Kong Baptist University, Hong Kong Special Administrative Region, China. Electronic address: wowchor@hkbu.edu.hk. FAU - Zhong, Linda AU - Zhong L AD - School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, China. Electronic address: scmcld@hkbu.edu.hk. LA - eng PT - Journal Article DEP - 20190620 PL - Scotland TA - Complement Ther Med JT - Complementary therapies in medicine JID - 9308777 SB - IM MH - Adult MH - China MH - Communication MH - Complementary Therapies/*psychology MH - Decision Making MH - Female MH - Health Personnel/*psychology MH - Hong Kong MH - Humans MH - Male MH - Medicine, Chinese Traditional/*psychology MH - Middle Aged MH - Patient Compliance/*psychology MH - Patient-Centered Care/methods MH - Physician-Patient Relations MH - Primary Health Care/methods MH - Referral and Consultation MH - Young Adult OTO - NOTNLM OT - Discourse analysis OT - Hong Kong OT - Patient-centred care OT - Primary care OT - Shared decision making OT - Traditional Chinese medicine (TCM) EDAT- 2019/07/25 06:00 MHDA- 2019/12/31 06:00 CRDT- 2019/07/24 06:00 PHST- 2019/03/07 00:00 [received] PHST- 2019/05/15 00:00 [revised] PHST- 2019/06/18 00:00 [accepted] PHST- 2019/07/24 06:00 [entrez] PHST- 2019/07/25 06:00 [pubmed] PHST- 2019/12/31 06:00 [medline] AID - S0965-2299(19)30303-6 [pii] AID - 10.1016/j.ctim.2019.06.013 [doi] PST - ppublish SO - Complement Ther Med. 2019 Aug;45:198-204. doi: 10.1016/j.ctim.2019.06.013. Epub 2019 Jun 20. PMID- 20728759 OWN - NLM STAT- MEDLINE DCOM- 20101202 LR - 20220330 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 32 IP - 8 DP - 2010 Aug TI - Parents' decision-making regarding vaccinating their children against influenza: A web-based survey. PG - 1448-67 LID - 10.1016/j.clinthera.2010.06.020 [doi] AB - BACKGROUND: Despite the recommendation from the Centers for Disease Control and Prevention that children between the ages of 6 months and 18 years be vaccinated against influenza annually, vaccination rates remain suboptimal. OBJECTIVES: This study was conducted to explore factors that influence parents' decisions regarding influenza vaccination for children aged 2 to 12 years, to quantify the relative importance of these factors, to identify an appropriate theoretical model for illustrating the relationships among these factors, and to characterize parents by their likelihood of vaccinating their children against influenza. METHODS: A quantitative Web-based survey was administered to a sample of parents from an online panel representative of the US population. Parents were stratified based on self-reported rates of their personal influenza vaccination (every year, sometimes, or never) and the age of their child (2-4 years or 5-12 years). The results were examined by parents' likelihood of vaccinating their child in the next year (high, medium, or low). Participants were asked to rank their agreement with statements representing various beliefs and perceptions about influenza and influenza vaccine on a scale from 1 = strongly agree to 5 = strongly disagree. Parents who indicated that they vaccinate their child every year were asked to select the drivers of their decision to vaccinate; parents who indicated that they never vaccinate their child were asked to select the barriers affecting their decision not to vaccinate; and parents who responded that they sometimes vaccinate their child were asked to select both the drivers and barriers affecting their decision. Participants were then asked to rank the importance of each driver or barrier on a scale from 1 = a little important to 5 = extremely important. Mean agreement ratings were calculated for parents' beliefs and perceptions about influenza and influenza vaccine and were compared across likelihood subgroups. Mean importance ratings of the drivers and barriers to vaccination were also calculated and compared across likelihood subgroups. RESULTS: The survey sample consisted of 500 parents; their mean (SD) age was 37.4 (6.82) years, 57.2% were female, and 78.2% were non-Hispanic white. Among those who reported that they vaccinated their child against influenza every year or sometimes, the major drivers of vaccination were prevention of influenza (95.1%), a doctor's recommendation (89.5%), and the desire to reduce influenza symptoms (83.3%). Among those who reported sometimes or never vaccinating their child against influenza, barriers to vaccination were more variable. The most common barriers were low perceived risk of influenza (46.0%), the perception that the vaccine caused influenza (44.0%), and side effects caused by the vaccine (36.6%). Distinct differences were found in beliefs and perceptions of influenza and influenza vaccine according to respondents' likelihood of vaccination. A high likelihood of vaccination was associated with a greater perceived threat of influenza and less concern about the efficacy and safety of the vaccine. Convenience was an important factor among parents with a medium likelihood of vaccination. The Health Belief Model was identified as an appropriate theoretical framework for illustrating the factors influencing parents' decision-making about influenza vaccination. CONCLUSIONS: Prevention of influenza, reduction of influenza symptoms, and doctor recommendation were the main drivers of parents' decision to vaccinate their child against influenza. Barriers to vaccination were more variable and primarily included the risk of adverse effects and the perceived low risk of influenza. Increasing parents' awareness of the threat of influenza and the efficacy and safety of the vaccine, as well as improving the convenience of getting vaccinated, may help improve rates of pediatric influenza vaccination. CI - 2010 Excerpta Medica Inc. All rights reserved. FAU - Flood, Emuella M AU - Flood EM AD - Oxford Outcomes, Bethesda, Maryland 20814, USA. emuella.flood@oxfordoutcomes.com FAU - Rousculp, Matthew D AU - Rousculp MD FAU - Ryan, Kellie J AU - Ryan KJ FAU - Beusterien, Kathleen M AU - Beusterien KM FAU - Divino, Victoria M AU - Divino VM FAU - Toback, Seth L AU - Toback SL FAU - Sasané, Medha AU - Sasané M FAU - Block, Stan L AU - Block SL FAU - Hall, Matthew C AU - Hall MC FAU - Mahadevia, Parthiv J AU - Mahadevia PJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Ther JT - Clinical therapeutics JID - 7706726 RN - 0 (Influenza Vaccines) SB - IM MH - Adult MH - *Attitude to Health MH - Centers for Disease Control and Prevention, U.S. MH - Child MH - Child, Preschool MH - Decision Making MH - Female MH - Health Care Surveys MH - Health Knowledge, Attitudes, Practice MH - Humans MH - Influenza Vaccines/*administration & dosage/adverse effects MH - Influenza, Human/*prevention & control MH - Internet MH - Male MH - Parents/*psychology MH - United States EDAT- 2010/08/24 06:00 MHDA- 2010/12/14 06:00 CRDT- 2010/08/24 06:00 PHST- 2010/04/23 00:00 [accepted] PHST- 2010/08/24 06:00 [entrez] PHST- 2010/08/24 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] AID - S0149-2918(10)00225-0 [pii] AID - 10.1016/j.clinthera.2010.06.020 [doi] PST - ppublish SO - Clin Ther. 2010 Aug;32(8):1448-67. doi: 10.1016/j.clinthera.2010.06.020. PMID- 21970036 OWN - NLM STAT- MEDLINE DCOM- 20111107 LR - 20111005 IS - 0233-528X (Print) IS - 0233-528X (Linking) VI - 45 IP - 4 DP - 2011 Jul-Aug TI - [The cascade scheme as a methodical platform for analysis of health risks in space flight and partially and fully analog conditions]. PG - 3-10 AB - Space anthropoecology, a subsection of human ecology, studies various aspects of physiological, psychological, social and professional adaptation to the extreme environment of space flight and human life and work in partially- and fully analogous conditions on Earth. Both SF and simulated extreme conditions are known for high human safety standards and a substantial analytic base that secures on-line analysis of torrent of information. Management evaluation and response to germing undesired developments aimed to curb their impact on the functioning of the crew-vehicle-environment system and human health involve the complete wealth of knowledge about risks to human health and performance. Spacecrew safety issues are tackled by experts of many specialties which emphasizes the importance of integral methodical approaches to risk estimation and mitigation, setting up barriers to adverse trends in human physiology and psychology in challenging conditions, and minimization of delayed effects on professional longevity and disorders in behavioral reactions. FAU - Ushakov, I B AU - Ushakov IB FAU - Poliakov, A V AU - Poliakov AV FAU - Usov, V M AU - Usov VM LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Aviakosm Ekolog Med JT - Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine JID - 9305904 SB - IM MH - *Adaptation, Physiological MH - Aerospace Medicine MH - *Astronauts MH - *Ecological Systems, Closed MH - Extraterrestrial Environment MH - Humans MH - Risk Assessment MH - *Safety MH - *Space Flight MH - Weightlessness/*adverse effects EDAT- 2011/10/06 06:00 MHDA- 2011/11/08 06:00 CRDT- 2011/10/06 06:00 PHST- 2011/10/06 06:00 [entrez] PHST- 2011/10/06 06:00 [pubmed] PHST- 2011/11/08 06:00 [medline] PST - ppublish SO - Aviakosm Ekolog Med. 2011 Jul-Aug;45(4):3-10. PMID- 12309446 OWN - PIP STAT- MEDLINE DCOM- 19800108 LR - 20191210 IS - 0301-861X (Print) IS - 0301-861X (Linking) VI - 7 IP - 4 DP - 1979 Apr TI - Danger of conception and safety of contraception. PG - 259-64 FAU - Leridon, H AU - Leridon H LA - eng LA - fre PT - Journal Article PL - France TA - Contracept Fertil Sex (Paris) JT - Contraception, fertilite, sexualite JID - 0411244 RN - 0 (Contraceptives, Oral) RN - 0 (Spermatocidal Agents) RN - 0 (Vaginal Creams, Foams, and Jellies) MH - *Coitus Interruptus MH - *Condoms MH - *Contraception MH - Contraception Behavior MH - *Contraceptive Devices, Female MH - *Contraceptives, Oral MH - Demography MH - Diagnosis MH - *Evaluation Studies as Topic MH - *Family Planning Services MH - Fertility MH - Fertilization MH - *Injections MH - *Intrauterine Devices MH - *Natural Family Planning Methods MH - Population MH - Population Dynamics MH - *Pregnancy MH - *Retention, Psychology MH - Sexual Behavior MH - Spermatocidal Agents MH - *Sterilization, Reproductive MH - *Vaginal Creams, Foams, and Jellies OID - PIP: 790679 OID - POP: 00051325 OAB - Measuring the effectiveness of a contraceptive method is a rather complicated task. The effectiveness of a method measures the reduction of risk, while the failure rate measures the number of pregnancies during the period of exposure to risk. The goal of contraception is, therefore, to reduce the risk of conception. It is extremely important, in evaluating the effectiveness of any method, to take into consideration the length of the period of observation, and to clearly distinguish between theoretical effectiveness, measured in the ideal conditions of highly motivated users exactly following instructions, and clinical effectiveness, measured in more realistic conditions. The Pearl index, the most widely used way of measuring the effectiveness of a method, takes into consideration only the periods during which a woman is exposed to the risk of pregnancy. The article includes a table with estimated failure and continuation rates for the various contraceptive methods. OABL- eng OTO - PIP OT - Barrier Methods OT - *Basal Body Temperature Method OT - *Coitus Interruptus OT - *Condom OT - Contraception OT - Contraception Continuation OT - *Contraception Failure OT - Contraceptive Methods OT - Contraceptive Usage OT - Demographic Factors OT - *Evaluation OT - Examinations And Diagnoses OT - Family Planning OT - Family Planning, Behavioral Methods OT - *Female Sterilization OT - Fertility OT - Fertilization OT - *Injectables OT - *Iud OT - *Male Sterilization OT - Natural Family Planning OT - *Oral Contraceptives OT - Population OT - Population Dynamics OT - *Pregnancy, Unplanned OT - Reproductive Behavior OT - *Retention OT - *Rhythm Method, Calendar OT - Sterilization, Sexual OT - Use-effectiveness OT - Vaginal Barrier Methods OT - *Vaginal Diaphragm OT - Vaginal Spermicides OT - *Vaginal Tablet EDAT- 1979/04/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1979/04/01 00:00 PHST- 1979/04/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1979/04/01 00:00 [entrez] PST - ppublish SO - Contracept Fertil Sex (Paris). 1979 Apr;7(4):259-64. PMID- 9575408 OWN - NLM STAT- MEDLINE DCOM- 19980729 LR - 20121115 IS - 0869-2092 (Print) IS - 0869-2092 (Linking) VI - 61 IP - 1 DP - 1998 Jan-Feb TI - [The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions]. PG - 30-2 AB - Administration of 0.05 g gidazepam once or twice daily for 7 days increased the stroke volume (SV) and circulation volume (CV) and reduced total peripheral resistance in neurotic patients. In healthy individuals 0.05 g gidazepam administered 60 min before an important examination stabilized CV. In subjects kept for 60 min in a microclimate with increasing temperature (55 +/- 2 degrees C, relative humidity 75-80%, rate of movement 1.5 m/min, rectal temperature at the end of exposure 39 degrees C) 0.05 g gidazepam administered 60 min before overheating optimally reorganized the reaction of the cardiovascular system, stabilized the SV at the initial level, which together with the growing heart rate increased the CV and provided sufficient perfusion of the vital organs. In healthy subjects working as operators for 4 h under conditions of hypercapnia (1.5% CO2), a single administration of 0.05 g gidazepam one hour before the beginning of work reduced the pulse pressure and increased the SV. The results obtained are evidence of the safety of using gidazepam as a corrector of emotion-induced disorders in operator performance under extreme conditions. FAU - Morozov, I S AU - Morozov IS AD - Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. FAU - Barchukov, V G AU - Barchukov VG FAU - Neznamov, G G AU - Neznamov GG LA - rus PT - Comparative Study PT - English Abstract PT - Journal Article TT - Vliianie gidazepama na funktsional'noe sostoianie serdechno-sosudistoĭ sistemy bol'nykh s nevroticheskimi reaktsiiami i u zdorovykh lits v oslozhnennykh usloviiakh. PL - Russia (Federation) TA - Eksp Klin Farmakol JT - Eksperimental'naia i klinicheskaia farmakologiia JID - 9215981 RN - 0 (Anti-Anxiety Agents) RN - 0 (Benzodiazepinones) RN - 0 (Cardiotonic Agents) RN - 12794-10-4 (Benzodiazepines) RN - XMJ87I93Y9 (gidazepam) SB - IM MH - Adolescent MH - Adult MH - Anti-Anxiety Agents/administration & dosage/*pharmacology MH - *Benzodiazepines MH - Benzodiazepinones/administration & dosage/*pharmacology MH - Cardiotonic Agents/administration & dosage/*pharmacology MH - Cardiovascular System/*drug effects/physiopathology MH - Drug Evaluation MH - Female MH - Humans MH - Male MH - Neurotic Disorders/*drug therapy/physiopathology/psychology MH - Psychophysiology MH - Reference Values MH - Time Factors EDAT- 1998/05/12 00:00 MHDA- 1998/05/12 00:01 CRDT- 1998/05/12 00:00 PHST- 1998/05/12 00:00 [pubmed] PHST- 1998/05/12 00:01 [medline] PHST- 1998/05/12 00:00 [entrez] PST - ppublish SO - Eksp Klin Farmakol. 1998 Jan-Feb;61(1):30-2. PMID- 12418281 OWN - NLM STAT- MEDLINE DCOM- 20021220 LR - 20151119 IS - 0033-2240 (Print) IS - 0033-2240 (Linking) VI - 59 IP - 6 DP - 2002 TI - [Social support and proper human relations in high school pupils in relation to psychosomatic disease prevention]. PG - 433-7 AB - The examination concerned 313 girls and boys from the second and third class of the secondary schools in Kraków. The translated German version questionnaire "Woman Self Image and Social Ideal" was used in the examination; mainly its parts such as: 1. "The social support" which includes 22 questions. 2. "Human Relations" which includes 64 questions. The five step scale of feeling was applied. One of the five possibilities was chosen by the examined persons and analysed. Stepwise regression was performed. More than half of the examined pupils have a good friend, who is helpful any time and who has never lets them down. They are relaxed with him, may discuss important problems and can give him charge over their home in their absence. 5% of the examined pupils could not share psychological problems with any friends and 10% could not count on house or flat care. 10% of pupils often felt as outsiders among other young people, while 1/3 did not experience such a feeling. The need of better understanding, care and support in the family and from close acquaintances was observed by 15%. Simultaneously only 14% claimed that relation in this matter were satisfactory. 19% of examined persons wanted more safety and friendship. Only 14% had a feeling of full safety. Juveniles most often claimed, that it is not difficult for them to buy a gift for another person (71% vs 2%), or cherish happiness of other people (67% vs 0.3%), and to express sympathy to others (65% vs 2.8%). More than half of the respondents judge themselves as non-aggressive against others, that they do not place their own needs above other peoples' needs, and that they are not afraid of contact with others. The frequency of choosing opposite extreme did not exceed 5% of the respondents. With the majority of questions we found a number of answers regarding discussed problem, ex. accepting orders from superiors (never--28%, sometimes--28%, average--21%, often--12%, very often--11%). In analogical proportions we found answers regarding such facts as a being strong and steady person, without bothering of hurting somebody's feelings or taking care of their own goals when anyone else is in need. We showed very differentiated, individual approach of examined adolescents to matters regarding their relations with people important for shaping their attitude towards life. It was also shown, that most of the 16-17 year old adolescents from Krakow enjoy a satisfactory relationship with people important in their lives, on the other hand, it is distressing that almost 20% of the examined pupils do not get enough support, care, safety and understanding either from their peers, families or adults. FAU - Kolarzyk, Emilia AU - Kolarzyk E AD - Zakład Higieny i Ekologii Collegium Medicum Uniwersytetu Jagiellońskiego, Kraków. FAU - Ostachowska-Gasior, Agnieszka AU - Ostachowska-Gasior A FAU - Kwiatkowski, Jacek AU - Kwiatkowski J LA - pol PT - English Abstract PT - Journal Article TT - Wsparcie społeczne oraz prawidłowe relacje interpersonalne licealistów krakowskich w aspekcie prewencji chorób o podłozu psychosomatycznym. PL - Poland TA - Przegl Lek JT - Przeglad lekarski JID - 19840720R SB - IM MH - Adolescent MH - Adolescent Behavior/*psychology MH - Female MH - Friends MH - Humans MH - *Interpersonal Relations MH - Male MH - *Peer Group MH - Poland MH - Regression Analysis MH - *Self Concept MH - *Social Support MH - Students/*psychology MH - Surveys and Questionnaires EDAT- 2002/11/07 04:00 MHDA- 2002/12/21 04:00 CRDT- 2002/11/07 04:00 PHST- 2002/11/07 04:00 [pubmed] PHST- 2002/12/21 04:00 [medline] PHST- 2002/11/07 04:00 [entrez] PST - ppublish SO - Przegl Lek. 2002;59(6):433-7. PMID- 9248499 OWN - NLM STAT- MEDLINE DCOM- 19971009 LR - 20190920 IS - 0001-4575 (Print) IS - 0001-4575 (Linking) VI - 29 IP - 4 DP - 1997 Jul TI - Fatigue, mindset and ecology in the hazard dominant environment. PG - 409-15 AB - Ratings made by 47 experienced drivers to 18 items of a Fatigue Advisory are highly consistent. Every item is rated 'very' or 'extremely important' to the safety of inexperienced drivers. In contrast, 'adequacy of knowledge' about fatigue is rated consistently lower. This inconsistency may reflect a culturally based confusion about fatigue. Education and public awareness campaigns need to emphasize that 'immoderate indulgence of driving' is as dangerous to safety as 'immoderate indulgence of alcohol'. A basic challenge is to improve understanding of the manner in which the experience of fatigue emerges during driving. Study of perceptual/cognitive manifestations aided by operational definition of fatigue as a 'declarative state' renders driving fatigue a definite observable subjective condition arising from continuous operation of a vehicle. Specific cognitive symptoms of fatigue such as boredom, tiredness, inattention, etc. emerging with driving fatigue, are circumscribed within the activity of driving itself and also reflect the particular conditions in which driving fatigue occurs. This approach reveals ecological dimensions to the problem. The specific experiences of driving fatigue are seen to emerge as a function of the driver environment relationship in a particular driving environment. It is suggested that the concept of the 'hazard dominant environment' and the compensating landscape perceptions of 'prospect' and 'refuge' proposed by Appleton [(1995) The Experience of Landscape. Wiley, London] in concert with the concept of environmental 'affordances' provided by Gibson [(1979) An Ecological Approach to Visual Perception. Houghton Mifflin, Boston] open promising possibilities for improving environmental education about driving fatigue. FAU - Nelson, T M AU - Nelson TM AD - Department of Psychology, University of Alberta, Edmonton, Canada. LA - eng PT - Journal Article PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Occupational/prevention & control/psychology MH - *Arousal MH - *Attention MH - Fatigue/prevention & control/*psychology MH - Humans MH - Occupational Diseases/prevention & control/*psychology MH - Proportional Hazards Models MH - Safety Management MH - *Social Environment MH - *Transportation EDAT- 1997/07/01 00:00 MHDA- 1997/07/01 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/07/01 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] AID - S0001457597000201 [pii] AID - 10.1016/s0001-4575(97)00020-1 [doi] PST - ppublish SO - Accid Anal Prev. 1997 Jul;29(4):409-15. doi: 10.1016/s0001-4575(97)00020-1. PMID- 12949315 OWN - NLM STAT- MEDLINE DCOM- 20031024 LR - 20190605 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 112 IP - 3 Pt 1 DP - 2003 Sep TI - Effects of budesonide inhalation suspension compared with cromolyn sodium nebulizer solution on health status and caregiver quality of life in childhood asthma. PG - e212-9 AB - OBJECTIVE: To compare the effects of 2 nebulizable controller asthma medications on caregiver and pediatric quality of life. METHODS: In this 52-week, randomized trial, children aged 2 to 6 years with mild to moderate persistent asthma received budesonide inhalation suspension 0.5 mg (total daily dose) once or twice daily (n = 168) or cromolyn sodium nebulizer solution 20 mg 4 times daily (n = 167) for 8 weeks, with dosage adjustment thereafter at the investigators' discretion. The Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ), Compliance/Caregiver Satisfaction Questionnaire (CCSQ), Modified Child Health Questionnaire-Parent Form 50 (CHQ-PF50), and Functional Status-II(R) (FS-II[R]) Questionnaire were administered at baseline and weeks 8, 28, and 52. Global assessments of ease of asthma management and child health status were obtained from caregivers and physicians at the end of the study. RESULTS: Improvements from baseline in domain-specific (activities and emotional function) and total PACQLQ scores were greater at each time point (weeks 8, 28, and 52) for caregivers of patients treated with budesonide compared with caregivers of patients receiving cromolyn sodium. Only the budesonide group met the criterion for a clinically important improvement (>or=0.5 unit change) in all PACQLQ domains by week 8, which was maintained at weeks 28 and 52. Moreover, improvements surpassed the criterion for moderate clinical importance (1.0 unit change) in all PACQLQ domains for the budesonide group, but this level of improvement was only achieved in the activities domain (at week 28) for the cromolyn sodium group. Based on the CCSQ, budesonide resulted in greater caregiver satisfaction, treatment convenience, ease of use, and compliance compared with cromolyn sodium. Thus, 90.7% of caregivers in the budesonide group were "completely or very satisfied" compared with 53.4% in the cromolyn sodium group. Over half (54.6%) of caregivers in the budesonide group rated budesonide "highly or very convenient" compared with 23% for cromolyn sodium; 77% rated budesonide "extremely or very easy" to use compared with 47% for cromolyn. Adherence with daily medication regimens was reported for 76% of children in the budesonide group compared with 57% in the cromolyn sodium group. Child health status, as indicated by mean FS-II(R) scores, showed improvements from baseline in both groups at weeks 8, 28, and 52. There was a trend for these improvements to be superior in the budesonide group. Additionally, budesonide was superior to cromolyn sodium in caregiver and physician global assessments. At the end of the study, 76% of caregivers of children receiving budesonide reported asthma management to be "a great deal easier" compared with the start of the study, and 74% rated the overall health status of their child as "much better now than 1 year ago." In contrast, only 29% and 37% of caregivers whose children received cromolyn sodium provided these respective ratings. CONCLUSIONS: Budesonide inhalation suspension improved the quality of life for caregivers of children with asthma. Caregivers of children treated with budesonide had significantly fewer limitations in daily activities and emotional functioning compared with caregivers of children treated with cromolyn sodium nebulizer solution. The improvements in caregiver quality of life occurred earlier with budesonide compared with cromolyn sodium. Only caregivers in the budesonide group had a clinically important mean change from baseline in all PACQLQ domains by week 8. These benefits were maintained at week 52. Children treated with budesonide inhalation suspension and cromolyn sodium experienced improvements in health status, assessed using the FS-II(R). The greatest differences between treatments were seen in the disease-specific portion of the FS-II(R), which relates impairments in functional status to the child's illness. Caregiver and physician global assessment indicated significantly better overall child health after 1 year of treatment with budesonide, supporting an improvement in health status. Clinical trials in children 4 to 16 years of age with asthma have demonstrated greater effectiveness of inhaled corticosteroids versus cromolyn sodium on several clinical measures of efficacy. Measures of asthma control in this study, reported in detail elsewhere [Leflein et al. Pediatrics 2002;109:866-872], also have shown greater improvements with budesonide therapy. Treatment with budesonide inhalation suspension resulted in a significantly lower mean rate of asthma exacerbations, significantly longer times to first asthma exacerbation, significantly longer times to first additional use of chronic asthma therapy, and significant improvements in asthma symptom scores and breakthrough medication use compared with cromolyn sodium therapy. Additionally, children receiving budesonide inhalation suspension experienced more symptom-free days and episode-free days compared with children receiving cromolyn sodium. Safety profiles were similar between the 2 treatment groups. Budesonide inhalation suspension was associated with significantly greater caregiver satisfaction, convenience, ease of use, and compliance compared with cromolyn sodium nebulizer solution. This greater caregiver satisfaction and quality of life may be related to the greater asthma control achieved in children treated with budesonide therapy compared with cromolyn sodium. In addition, the convenience of once- or twice-daily dosing with budesonide inhalation suspension, compared with 3- or 4-times-daily dosing of cromolyn sodium, may decrease caregiver burden and enhance the willingness of caregivers to adhere to treatment regimens prescribed for their young children with asthma. This effect on caregiver adherence could further improve treatment effectiveness. This is the first clinical trial comparing the effects of a nebulized corticosteroid with that of an alternative nebulized therapy on quality of life in young children with asthma and their families. Compared with nebulized cromolyn sodium, budesonide inhalation suspension not only provides better overall child health status and asthma management, but greater caregiver quality of life and greater caregiver satisfaction, convenience, ease of use, and compliance. FAU - Murphy, Kevin R AU - Murphy KR AD - Midwest Allergy & Asthma Clinic, Midwest Children's Chest Physicians, Omaha, Nebraska. FAU - Fitzpatrick, Sherahe AU - Fitzpatrick S FAU - Cruz-Rivera, Mario AU - Cruz-Rivera M FAU - Miller, Christopher J AU - Miller CJ FAU - Parasuraman, Bhash AU - Parasuraman B LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 RN - 0 (Anti-Asthmatic Agents) RN - 0 (Bronchodilator Agents) RN - 0 (Suspensions) RN - 51333-22-3 (Budesonide) RN - Q2WXR1I0PK (Cromolyn Sodium) SB - IM MH - Administration, Inhalation MH - Anti-Asthmatic Agents/administration & dosage/therapeutic use MH - Asthma/*drug therapy/*psychology MH - Bronchodilator Agents/administration & dosage/therapeutic use MH - Budesonide/*administration & dosage/therapeutic use MH - Caregivers/*psychology/statistics & numerical data MH - Child MH - Child, Preschool MH - Cromolyn Sodium/*administration & dosage/therapeutic use MH - Health Status MH - Humans MH - Job Satisfaction MH - *Nebulizers and Vaporizers MH - Patient Compliance/psychology/statistics & numerical data MH - Patient Satisfaction/statistics & numerical data MH - Quality of Life/*psychology MH - Surveys and Questionnaires MH - Suspensions EDAT- 2003/09/02 05:00 MHDA- 2003/10/25 05:00 CRDT- 2003/09/02 05:00 PHST- 2003/09/02 05:00 [pubmed] PHST- 2003/10/25 05:00 [medline] PHST- 2003/09/02 05:00 [entrez] AID - 10.1542/peds.112.3.e212 [doi] PST - ppublish SO - Pediatrics. 2003 Sep;112(3 Pt 1):e212-9. doi: 10.1542/peds.112.3.e212. PMID- 2267840 OWN - NLM STAT- MEDLINE DCOM- 19910213 LR - 20081121 IS - 0049-8610 (Print) IS - 0049-8610 (Linking) VI - 36 IP - 8 DP - 1990 Aug TI - [Effects of stress and strain on health status and traffic behavior in professional drivers]. PG - 421-4 AB - The paper is based on the expectation, that the short and middle term sequences of strain in connection with the job demands on professional motorists have an influence on the traffic safety. Increasing rush, higher pretensions on the carriers for instance just-in-time-production, 24-hours-service and the competition between the countries of the EEC raise the level of demands. New arrangements between the countries of the EEC allow longer shifts. In extreme cases 84 hours per week are possible. The aim of our examination consists in showing the real working-conditions of professional drivers and their effects on the attitude to car-driving and to get information on the psychosomatic state of the drivers. FAU - Frieling, E AU - Frieling E AD - Gesamthochschule Kassel, BRD. FAU - Kiegeland, P AU - Kiegeland P LA - ger PT - English Abstract PT - Journal Article TT - Auswirkungen von Belastung und Beanspruchung auf Befinden und Verkehrsverhalten von Berufskraftfahrern. PL - Germany TA - Z Gesamte Hyg JT - Zeitschrift fur die gesamte Hygiene und ihre Grenzgebiete JID - 0420111 SB - IM MH - *Arousal MH - Automobile Driving/*psychology MH - Humans MH - Occupational Diseases/*psychology MH - Physical Exertion MH - Stress, Psychological/*complications MH - Work Schedule Tolerance EDAT- 1990/08/01 00:00 MHDA- 1990/08/01 00:01 CRDT- 1990/08/01 00:00 PHST- 1990/08/01 00:00 [pubmed] PHST- 1990/08/01 00:01 [medline] PHST- 1990/08/01 00:00 [entrez] PST - ppublish SO - Z Gesamte Hyg. 1990 Aug;36(8):421-4. PMID- 12611202 OWN - NLM STAT- MEDLINE DCOM- 20030326 LR - 20151119 IS - 0040-5957 (Print) IS - 0040-5957 (Linking) VI - 57 IP - 5 DP - 2002 Sep-Oct TI - [Benign prostatic hyperplasia: patients' perception of medical treatment and their expectations. Results of a french survey involving patients treated with finasteride]. PG - 473-83 AB - Benign prostatic hyperplasia (BPH) is increasingly common in medical practice, as a result of the inevitable aging of the population. The current therapeutic strategy includes three alternatives: watchful waiting, medical treatment and invasive therapy. Finasteride is one of the pharmacological options available. Many clinical studies have demonstrated its efficacy and good safety profile in patients with BPH. The survey we report provides new insights into what has to date been a purely therapeutic approach by taking into consideration patients' expectations and their perception of finasteride treatment. Results indicate that the main preoccupation for patients with BPH is that the pharmacological treatment will reduce the risk of major urological complications and the need for surgery (treatment characteristics considered as very or extremely important by 88 and 93% of patients, respectively). Decreasing symptoms and improving quality of life take second place after these primary concerns. Patient perception of finasteride is excellent. Nearly all patients are satisfied by the efficacy of the treatment, 89% of them reporting good to extremely good improvement of symptoms, the rapid onset of relief being particularly important. The efficacy of finasteride is not hindered by any tolerability issues and is further strengthened by its ease of use. Although this novel survey includes a number of biases, it nevertheless demonstrates that treatment of BPH with finasteride is well accepted by patients and satisfies their expectations. In addition, it provides a mass of general epidemiological data on patients with BPH, as well as on current medical practice regarding this condition. FAU - Teillac, P AU - Teillac P AD - Service d'Urologie, Hôpital Saint-Louis, Paris, France. LA - fre PT - English Abstract PT - Journal Article TT - Hypertrophie bénigne de la prostate: attentes des patients et perception du traitement. Résultats d'une enquête menée en France auprès de patients traités par finastéride. PL - France TA - Therapie JT - Therapie JID - 0420544 RN - 0 (Enzyme Inhibitors) RN - 57GNO57U7G (Finasteride) SB - IM MH - Aged MH - Data Collection MH - Enzyme Inhibitors/*therapeutic use MH - Finasteride/*therapeutic use MH - France MH - Humans MH - Male MH - Middle Aged MH - Patient Satisfaction MH - Prostatic Hyperplasia/*psychology/*therapy MH - Surveys and Questionnaires EDAT- 2003/03/04 04:00 MHDA- 2003/03/27 05:00 CRDT- 2003/03/04 04:00 PHST- 2003/03/04 04:00 [pubmed] PHST- 2003/03/27 05:00 [medline] PHST- 2003/03/04 04:00 [entrez] PST - ppublish SO - Therapie. 2002 Sep-Oct;57(5):473-83. PMID- 16715936 OWN - NLM STAT- MEDLINE DCOM- 20060705 LR - 20180222 IS - 0029-0831 (Print) IS - 0029-0831 (Linking) VI - 38 IP - 3 DP - 2006 May TI - [Secondary progressive multiple sclerosis in childhood--interferon beta 1b treatment]. PG - 209-13 AB - Multiple sclerosis (MS) is rare in children and the efficacy and safety of interferon beta 1b (IFN-beta 1b) treatment in childhood MS has not yet been established. We started to treat a boy who suffered from relapsing remitting MS with IFN-beta 1b at 8.5 years of age, because he had severe neurological disability in consequence of frequent relapses and incomplete remission. After initiating IFN-beta 1b treatment, his clinical course moved to secondary progressive (SP) MS, and he demonstrated poor improvement in degenerative progression and his disability continued to worsen. We could speculate that IFN-beta 1b was not effective regarding the degenerative component of childhood MS as in that of adult MS. SPMS is extremely rare in children, and this case would provide a very important implication to predict the tolerability of IFN-beta 1b treatment depending on the type of clinical course in childhood MS. FAU - Higurashi, Norimichi AU - Higurashi N AD - Department of Pediatrics, Jikei University School of Medicine, Tokyo. nori_@jikei.ac.jp FAU - Hamano, Shin-ichiro AU - Hamano S FAU - Eto, Yoshikatsu AU - Eto Y LA - jpn PT - Case Reports PT - English Abstract PT - Journal Article PL - Japan TA - No To Hattatsu JT - No to hattatsu = Brain and development JID - 0215224 RN - 145155-23-3 (Interferon beta-1b) RN - 77238-31-4 (Interferon-beta) SB - IM MH - Child MH - Disease Progression MH - Humans MH - Interferon beta-1b MH - Interferon-beta/adverse effects/*therapeutic use MH - Magnetic Resonance Imaging MH - Male MH - Multiple Sclerosis, Chronic Progressive/diagnosis/*drug therapy/physiopathology/psychology MH - Recurrence MH - Treatment Outcome EDAT- 2006/05/24 09:00 MHDA- 2006/07/06 09:00 CRDT- 2006/05/24 09:00 PHST- 2006/05/24 09:00 [pubmed] PHST- 2006/07/06 09:00 [medline] PHST- 2006/05/24 09:00 [entrez] PST - ppublish SO - No To Hattatsu. 2006 May;38(3):209-13.