PMID- 30631424 OWN - NLM STAT- MEDLINE DCOM- 20190306 LR - 20200309 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 7 DP - 2018 TI - Recent advances in improving the effectiveness and reducing the complications of abortion. LID - F1000 Faculty Rev-1881 [pii] LID - 10.12688/f1000research.15441.1 [doi] AB - When conducted in a legal setting and under safe conditions, abortion is an extremely effective and safe procedure. Tragically, almost half of all abortions that take place in the world are conducted under unsafe conditions, mostly in countries where abortion is illegal or highly restricted. These unsafe abortions are a major cause of maternal death and disability. Restricting a woman's access to abortion does not prevent abortion but simply leads to more unsafe abortions. Barriers to safe abortion are many but include legal barriers, health policy barriers, shortages of trained healthcare workers, and stigma surrounding abortion. This commentary will consider some recent advances to improve access to safe abortion as well as refinements in abortion methods and service delivery in settings where safe abortion is available that further improve the care and wellbeing of women who seek abortion. FAU - Cameron, Sharon AU - Cameron S AUID- ORCID: 0000-0002-1168-2276 AD - Chalmers Centre, NHS Lothian & University of Edinburgh, 2a Chalmers Street, Edinburgh, EH3 9ES, UK. LA - eng PT - Journal Article PT - Review DEP - 20181202 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Abortion, Induced/adverse effects/*methods/mortality/trends MH - Developing Countries MH - Female MH - Health Services Accessibility/legislation & jurisprudence/*standards/statistics & numerical data MH - Humans MH - Maternal Mortality MH - Patient Safety MH - Pregnancy PMC - PMC6281004 OTO - NOTNLM OT - abortion OT - complications OT - global abortion OT - medical abortion OT - mifepristone OT - misoprostol OT - surgical abortion OT - termination OT - unsafe abortion COIS- No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed. EDAT- 2019/01/12 06:00 MHDA- 2019/03/07 06:00 PMCR- 2018/12/02 CRDT- 2019/01/12 06:00 PHST- 2018/11/16 00:00 [accepted] PHST- 2019/01/12 06:00 [entrez] PHST- 2019/01/12 06:00 [pubmed] PHST- 2019/03/07 06:00 [medline] PHST- 2018/12/02 00:00 [pmc-release] AID - F1000 Faculty Rev-1881 [pii] AID - 10.12688/f1000research.15441.1 [doi] PST - epublish SO - F1000Res. 2018 Dec 2;7:F1000 Faculty Rev-1881. doi: 10.12688/f1000research.15441.1. eCollection 2018. PMID- 10151618 OWN - NLM STAT- MEDLINE DCOM- 19951205 LR - 20220408 IS - 0963-8172 (Print) IS - 0963-8172 (Linking) VI - 4 IP - 2 DP - 1995 Jun TI - Understanding adverse events: human factors. PG - 80-9 AB - (1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole. FAU - Reason, J AU - Reason J AD - Department of Psychology, University of Manchester, UK. LA - eng PT - Journal Article PL - England TA - Qual Health Care JT - Quality in health care : QHC JID - 9209948 MH - Accidents, Occupational/*prevention & control/psychology MH - Automation MH - Behavior MH - England MH - Health Personnel/*psychology MH - Health Services Research MH - Humans MH - Iatrogenic Disease/*prevention & control MH - Patient Care Team/standards MH - Psychology, Industrial MH - Risk Management/*standards PMC - PMC1055294 EDAT- 1995/05/08 00:00 MHDA- 1995/05/08 00:01 PMCR- 1995/06/01 CRDT- 1995/05/08 00:00 PHST- 1995/05/08 00:00 [pubmed] PHST- 1995/05/08 00:01 [medline] PHST- 1995/05/08 00:00 [entrez] PHST- 1995/06/01 00:00 [pmc-release] AID - 10.1136/qshc.4.2.80 [doi] PST - ppublish SO - Qual Health Care. 1995 Jun;4(2):80-9. doi: 10.1136/qshc.4.2.80. PMID- 32731696 OWN - NLM STAT- MEDLINE DCOM- 20200804 LR - 20200804 IS - 0043-5147 (Print) IS - 0043-5147 (Linking) VI - 73 IP - 4 DP - 2020 TI - Medical and psychological aspects of safety and adaptation of military personnel to extreme conditions. PG - 679-683 AB - OBJECTIVE: The aim: To determine the dynamics of adaptation resources and the level of psychological safety of the personality in service members of the National Guard of Ukraine who participated in combat operations in the East of Ukraine. PATIENTS AND METHODS: Materials and methods: To determine the peculiarities of military personnel adaptation to the combat activity, the "Adaptability-200" and "Disdaptability-45" methodologies were used. To determine the level of psychological safety of combatants we used "Diagnosis of psychological safety personality" and "Express diagnosis of psychological safety personality" Methodologies. The study was carried out during 2017, with 163 military participating. RESULTS: Results: Being 2-3 weeks in combat conditions, 54% service members revealed high, 32% - average level of adaptability, and in 14% of them signs of non-adaptability were detected. The data of adaptation resources of combatants correlates with the results of diagnostics of psychological safety of personality: in 43% of them high level, 42% - average and 15% - low level of psychological safety were revealed. CONCLUSION: Conclusions: The data obtained in the absolute majority of service members (86%) shows a good adaptability to combat conditions, and allows predicting adequate response to extreme conditions, high probability of preserving of the mental health and disability after the influence of vital factors. FAU - Prykhodko, Ihor I AU - Prykhodko II AD - National Academy of the National Guard of Ukraine, Kharkiv, Ukraine. FAU - Bielai, Serhii V AU - Bielai SV AD - National Academy of the National Guard of Ukraine, Kharkiv, Ukraine. FAU - Hrynzovskyi, Anatolii M AU - Hrynzovskyi AM AD - Bogomolets National Medical University, Kyiv, Ukraine. FAU - Zhelaho, Anatolii М AU - Zhelaho AМ AD - National Academy of the National Guard of Ukraine, Kharkiv, Ukraine. FAU - Hodlevskyi, Serhii O AU - Hodlevskyi SO AD - National Academy of the National Guard of Ukraine, Kharkiv, Ukraine. FAU - Kalashchenko, Svitlana I AU - Kalashchenko SI AD - Bogomolets National Medical University, Kyiv, Ukraine. LA - eng PT - Journal Article PL - Poland TA - Wiad Lek JT - Wiadomosci lekarskie (Warsaw, Poland : 1960) JID - 9705467 SB - IM MH - Adaptation, Physiological MH - Humans MH - Mental Health MH - *Military Personnel MH - Personality MH - Ukraine OTO - NOTNLM OT - adaptation OT - psychological safety OT - service members OT - extreme conditions EDAT- 2020/08/01 06:00 MHDA- 2020/08/05 06:00 CRDT- 2020/08/01 06:00 PHST- 2020/08/01 06:00 [entrez] PHST- 2020/08/01 06:00 [pubmed] PHST- 2020/08/05 06:00 [medline] PST - ppublish SO - Wiad Lek. 2020;73(4):679-683. PMID- 35489093 OWN - NLM STAT- MEDLINE DCOM- 20220530 LR - 20220530 IS - 1879-3363 (Electronic) IS - 0025-326X (Linking) VI - 179 DP - 2022 Jun TI - Can tolerances of multiple stressors and calculated safety margins in fiddler crabs predict responses to extreme environmental conditions resulting from climate change? PG - 113674 LID - S0025-326X(22)00356-3 [pii] LID - 10.1016/j.marpolbul.2022.113674 [doi] AB - To comprehend mangrove crab responses to predicted global climate changes, we assessed submersion and desiccation survival durations and salinity tolerances and upper thermal limits in fiddler crabs from Isla del Carmen, Yucatán Peninsula. Based on their tolerances of extreme ambient conditions, we also calculated safety margins using abiotic monitoring data. The two most terrestrial species, Minuca rapax and Leptuca panacea, exhibited submersion tolerances of from 22 to 40 h, and desiccation tolerances of from 30 to 55 h; LC(50)'s were ≈45‰S and UT(50)'s were ≈40 °C. The two least terrestrial species, M. vocator and L. speciosa, were less tolerant of all experimental challenges, showing submersion and desiccation tolerances of <6 h, and LC(50)'s of 36‰S and UT(50)'s of 38 °C. While these fiddler crabs inhabit niches closer to their salinity and desiccation/submersion tolerances than to their temperature limits, all are clearly vulnerable to the multiple stressors that accompany anticipated global climate change. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Capparelli, Mariana V AU - Capparelli MV AD - Estación el Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km. 9.5, C. P 24157 Ciudad del Carmen, Campeche, Mexico. Electronic address: marivcap@gmail.com. FAU - McNamara, John C AU - McNamara JC AD - Departamento de Biologia, Faculdade de Filosofa, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brazil; Centro de Biologia Marinha, Universidade de São Paulo, São Sebastião, SP 11600-000, Brazil. FAU - Thurman, Carl L AU - Thurman CL AD - Department of Biology, University of Northern Iowa, Cedar Falls, IA 50614-0421, USA. FAU - Pérez-Ceballos, Rosela AU - Pérez-Ceballos R AD - Estación el Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km. 9.5, C. P 24157 Ciudad del Carmen, Campeche, Mexico. FAU - Gómez-Ponce, Mario A AU - Gómez-Ponce MA AD - Estación el Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km. 9.5, C. P 24157 Ciudad del Carmen, Campeche, Mexico. FAU - Cardoso-Mohedano, José-Gilberto AU - Cardoso-Mohedano JG AD - Estación el Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km. 9.5, C. P 24157 Ciudad del Carmen, Campeche, Mexico. FAU - Moulatlet, Gabriel M AU - Moulatlet GM AD - Red de Biología Evolutiva, Instituto de Ecología, A.C., Xalapa, Veracruz, Mexico. LA - eng PT - Journal Article DEP - 20220427 PL - England TA - Mar Pollut Bull JT - Marine pollution bulletin JID - 0260231 SB - IM MH - Animals MH - *Brachyura/physiology MH - Climate Change MH - Salinity MH - Temperature OTO - NOTNLM OT - Flooding regime OT - Gelasiminae OT - Multiple stressors OT - Predicted climate change OT - Salinity challenge OT - Submersion and desiccation OT - Temperature EDAT- 2022/05/01 06:00 MHDA- 2022/05/31 06:00 CRDT- 2022/04/30 18:02 PHST- 2021/12/16 00:00 [received] PHST- 2022/03/18 00:00 [revised] PHST- 2022/04/16 00:00 [accepted] PHST- 2022/05/01 06:00 [pubmed] PHST- 2022/05/31 06:00 [medline] PHST- 2022/04/30 18:02 [entrez] AID - S0025-326X(22)00356-3 [pii] AID - 10.1016/j.marpolbul.2022.113674 [doi] PST - ppublish SO - Mar Pollut Bull. 2022 Jun;179:113674. doi: 10.1016/j.marpolbul.2022.113674. Epub 2022 Apr 27. PMID- 35622383 OWN - NLM STAT- MEDLINE DCOM- 20230405 LR - 20230405 IS - 2376-9130 (Electronic) IS - 1080-3548 (Linking) VI - 29 IP - 2 DP - 2023 Jun TI - A review of construction workforce health challenges and strategies in extreme weather conditions. PG - 773-784 LID - 10.1080/10803548.2022.2082138 [doi] AB - Construction sites continue to operate despite inclement weather, exposing workers to unpleasant working circumstances that can lead to various physical and mental health challenges. A thorough literature review yielded 21 challenges for hot weather conditions such as heat stroke, kidney disease, heat cramps, anxiety and depression, and 20 challenges for cold weather conditions like asthma, frostbite, musculoskeletal disorders and hallucination. Workers vulnerable to hot and cold weather based on demographic characteristics were identified. The study also provides 27 strategies to address the challenges experienced in hot and cold weather conditions. Some of these include ensuring that workers stay hydrated, scheduling sufficient rest periods and allowing workers to self-pace. The results of this study will help construction decision-makers and project managers understand the difficulties faced by a field workforce who labors in extreme working conditions on construction sites and will facilitate adoption of strategies that can prevent weather-related physical and mental health problems. FAU - Karthick, Sanjgna AU - Karthick S AD - Department of Civil Engineering, University of Texas at Arlington, USA. FAU - Kermanshachi, Sharareh AU - Kermanshachi S AD - Department of Civil Engineering, University of Texas at Arlington, USA. FAU - Pamidimukkala, Apurva AU - Pamidimukkala A AD - Department of Civil Engineering, University of Texas at Arlington, USA. FAU - Namian, Mostafa AU - Namian M AD - Department of Construction Management, East Carolina University, USA. LA - eng PT - Journal Article PT - Review DEP - 20220617 PL - England TA - Int J Occup Saf Ergon JT - International journal of occupational safety and ergonomics : JOSE JID - 9507598 SB - IM MH - Humans MH - *Extreme Weather MH - Weather MH - Cold Temperature MH - *Occupational Health MH - Workforce MH - Hot Temperature OTO - NOTNLM OT - construction workers OT - extreme weather OT - health challenges OT - worker health OT - worker safety EDAT- 2022/05/28 06:00 MHDA- 2023/04/05 06:42 CRDT- 2022/05/27 11:42 PHST- 2023/04/05 06:42 [medline] PHST- 2022/05/28 06:00 [pubmed] PHST- 2022/05/27 11:42 [entrez] AID - 10.1080/10803548.2022.2082138 [doi] PST - ppublish SO - Int J Occup Saf Ergon. 2023 Jun;29(2):773-784. doi: 10.1080/10803548.2022.2082138. Epub 2022 Jun 17. PMID- 35593835 STAT- Publisher CTDT- 20230227 PB - StatPearls Publishing DP - 2025 Jan TI - OSHA Electrical Safety. BTI - StatPearls AB - The Occupational Safety and Health Administration (OSHA) is a branch of the United States Department of Labor that oversees workplace safety and sets safety standards for specific working conditions. Many of the guidelines OSHA establishes transcend many fields. However, some are more specific to healthcare, such as working with blood and bloodborne pathogens, laboratory chemicals, infectious diseases, and personal protective equipment standards. One OSHA workplace safety topic that applies to almost all fields is electrical safety, ranging from standard electrical outlets or extension cords to specific workplace hazards like power lines or massive generators in places like factories or dams. Harnessing electricity is 1 of the most important modern inventions in nearly all life aspects. Still, the unique physical properties of electrical energy that allow it to power our world also make it extremely dangerous. CI - Copyright © 2025, StatPearls Publishing LLC. FAU - Tupper, Connor AU - Tupper C AD - Creighton University School of Medicine FAU - Doyal, Alexander AU - Doyal A AD - University of North Carolina at Chapel Hill LA - eng PT - Study Guide PT - Book Chapter PL - Treasure Island (FL) COIS- Disclosure: Connor Tupper declares no relevant financial relationships with ineligible companies. Disclosure: Alexander Doyal declares no relevant financial relationships with ineligible companies. EDAT- 2023/02/27 00:00 CRDT- 2023/02/27 00:00 AID - NBK580528 [bookaccession] PMID- 38196415 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240110 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 15 IP - 12 DP - 2023 Dec TI - Public Health in Antarctica. PG - e50263 LID - 10.7759/cureus.50263 [doi] LID - e50263 AB - Public health in Antarctica is a pertinent issue that often gets overlooked. While the term 'public health' generally refers to the health of a larger community or the public, this concept is equally applicable to small, isolated populations, such as those residing in Antarctica. The principles of public health, including disease prevention, health promotion, and safety, are crucial for the well-being of those living and working in Antarctica. With the dramatic increase in tourist visits to Antarctica over the past decade, public health issues have become increasingly relevant and critical for the operation of base stations. In this article, we will discuss the need and relevance of public health for this growing community, the health issues they face due to extreme environmental conditions, and the measures to mitigate them. CI - Copyright © 2023, Nath et al. FAU - Nath, Ravindra AU - Nath R AD - Preventive Medicine, National Centre for Polar and Ocean Research, Ministry of Earth Sciences, Government of India, Goa, IND. FAU - Sindwani, Pooja AU - Sindwani P AD - Community Medicine, Teerthanker Mahaveer Medical College and Research Centre, Moradabad, IND. LA - eng PT - Editorial DEP - 20231210 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC10775640 OTO - NOTNLM OT - antarctica OT - mental health OT - occupational safety OT - preventive medicine OT - public health COIS- The authors have declared that no competing interests exist. EDAT- 2024/01/10 06:42 MHDA- 2024/01/10 06:43 PMCR- 2023/12/10 CRDT- 2024/01/10 03:35 PHST- 2023/12/10 00:00 [accepted] PHST- 2024/01/10 06:43 [medline] PHST- 2024/01/10 06:42 [pubmed] PHST- 2024/01/10 03:35 [entrez] PHST- 2023/12/10 00:00 [pmc-release] AID - 10.7759/cureus.50263 [doi] PST - epublish SO - Cureus. 2023 Dec 10;15(12):e50263. doi: 10.7759/cureus.50263. eCollection 2023 Dec. PMID- 37670839 OWN - NLM STAT- MEDLINE DCOM- 20230907 LR - 20230911 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 11 DP - 2023 TI - Study on thermal health and its safety management mode for the working environment. PG - 1227630 LID - 10.3389/fpubh.2023.1227630 [doi] LID - 1227630 AB - Thermal health concerns have gained significant attention due to the heightened health risks faced by workers who are exposed to extreme thermal environments for prolonged periods. To ensure the occupational health and safety of such workers, and to enhance work efficiency, it is imperative to examine the characteristics of thermal health in the working environment. This study proposes three key elements of thermal health in the working environment, namely thermal health states, absence of heat-related illnesses, and heat adaptability, which can be used to develop a safety management framework for thermal health. By exploring the interconnections between these elements, the study summarizes their features and outlines the necessary precautions to safeguard them. The PDCA (plan/do/check/action) cycle management mode is utilized as a framework, with the three components of thermal health forming the core, to establish a safety management mode for thermal health. To ensure that employees work in a safe, healthy, comfortable, and productive environment, the assessment and control objectives of the thermal environment are regularly revised through the use of labor protection technology and thermal environment control technology. This paper presents a PDCA cycle safety management mode based on the characteristics of thermal health, which offers novel insights and approaches for assessing and managing workers' thermal health. CI - Copyright © 2023 Wang, Jiang, Yang, Bai and Yu. FAU - Wang, Jue AU - Wang J AD - Key Laboratory of Mine Thermodynamic Disasters and Control of Ministry of Education, Liaoning Technical University, Fuxin, Liaoning, China. AD - School of Safety Science and Engineering, Liaoning Technical University, Fuxin, Liaoning, China. AD - School of Civil Engineering, Liaoning Technical University, Fuxin, Liaoning, China. FAU - Jiang, Cheng AU - Jiang C AD - School of Civil Engineering, Liaoning Technical University, Fuxin, Liaoning, China. FAU - Yang, Guang AU - Yang G AD - School of Civil Engineering, Liaoning Technical University, Fuxin, Liaoning, China. FAU - Bai, Gang AU - Bai G AD - Key Laboratory of Mine Thermodynamic Disasters and Control of Ministry of Education, Liaoning Technical University, Fuxin, Liaoning, China. AD - School of Safety Science and Engineering, Liaoning Technical University, Fuxin, Liaoning, China. FAU - Yu, Shixuan AU - Yu S AD - School of Civil Engineering, Liaoning Technical University, Fuxin, Liaoning, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20230821 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 621BVT9M36 (Fenbendazole) SB - IM MH - Humans MH - *Working Conditions MH - *Fenbendazole MH - Health Status MH - Hot Temperature MH - Safety Management PMC - PMC10475595 OTO - NOTNLM OT - PDCA OT - labor protection OT - safety management mode OT - thermal health OT - working environment COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/09/06 06:42 MHDA- 2023/09/07 06:42 PMCR- 2023/08/21 CRDT- 2023/09/06 03:45 PHST- 2023/05/23 00:00 [received] PHST- 2023/07/31 00:00 [accepted] PHST- 2023/09/07 06:42 [medline] PHST- 2023/09/06 06:42 [pubmed] PHST- 2023/09/06 03:45 [entrez] PHST- 2023/08/21 00:00 [pmc-release] AID - 10.3389/fpubh.2023.1227630 [doi] PST - epublish SO - Front Public Health. 2023 Aug 21;11:1227630. doi: 10.3389/fpubh.2023.1227630. eCollection 2023. PMID- 35668256 OWN - NLM STAT- MEDLINE DCOM- 20221013 LR - 20241016 IS - 1614-7499 (Electronic) IS - 0944-1344 (Print) IS - 0944-1344 (Linking) VI - 29 IP - 50 DP - 2022 Oct TI - Extreme environmental temperatures and motorcycle crashes: a time-series analysis. PG - 76251-76262 LID - 10.1007/s11356-022-21151-8 [doi] AB - Extreme temperature could affect traffic crashes by influencing road safety, vehicle performance, and drivers' behavior and abilities. Studies evaluating the impacts of extreme temperatures on the risk of traffic crashes have mainly overlooked the potential role of vehicle air conditioners. The aim of this study, therefore, was to evaluate the effect of exposure to extreme cold and hot temperatures on seeking medical attention due to motorcycle crashes. The study was conducted in Iran by using medical attendance for motorcycle crashes from March 2011 to June 2017. Data on daily minimum, mean and maximum temperature (°C), relative humidity (%), wind velocity (km/h), and precipitation (mm/day) were collected. We developed semi-parametric generalized additive models following a quasi-Poisson distribution with the distributed nonlinear lag model to estimate the immediate and lagged associations (reported as relative risk [RR], and 95% confidence interval [CI]). Between March 2011 and June 2017, 36,079 medical attendances due to motorcycle road traffic crashes were recorded (15.8 ± 5.92 victims per day). In this time period, the recorded temperature ranged from -11.2 to 45.4 °C (average: 25.5 ± 11.0 °C). We found an increased risk of medical attendance for motorcycle crashes (based on maximum daily temperature) at both extremely cold (1st percentile) and hot (99th percentile) temperatures and also hot (75th percentile) temperatures, mainly during lags 0 to 3 days (e.g., RR: 1.12 [95% CI: 1.05: 1.20]; RR: 1.08 [95% CI: 1.01: 1.16]; RR: 1.20 [95% CI: 1.09: 1.32] at lag0 for extremely cold, hot, and extremely hot conditions, respectively). The risk estimates for extremely hot temperatures were larger than hot and extremely cold temperatures. We estimated that 11.01% (95% CI: 7.77:14.06) of the medical attendance for motorcycle crashes is estimated to be attributable to non-optimal temperature (using mean temperature as exposure variable). Our findings have important public health messaging, given the considerable burden associated with road traffic injury, particularly in low- and middle-income countries. CI - © 2022. The Author(s). FAU - Zare Sakhvidi, Mohammad Javad AU - Zare Sakhvidi MJ AUID- ORCID: 0000-0002-0024-6743 AD - Department of Occupational Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Yang, Jun AU - Yang J AD - School of Public Health, Guangzhou Medical University, Guangzhou, 511436, China. FAU - Mohammadi, Danial AU - Mohammadi D AD - Department of Occupational Health, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - FallahZadeh, Hussein AU - FallahZadeh H AD - Department of Epidemiology and Biostatistics, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Mehrparvar, Amirhooshang AU - Mehrparvar A AD - Department of Occupational Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Stevenson, Mark AU - Stevenson M AD - Melbourne School of Design/Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Basagaña, Xavier AU - Basagaña X AD - ISGlobal, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. AD - CIBER Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro, 3-5, 28029, Madrid, Spain. FAU - Gasparrini, Antonio AU - Gasparrini A AD - Department of Public Health, Environments and Society, London School Hygiene & Tropical Medicine, London, UK. AD - Centre for Statistical Methodology, London School Hygiene & Tropical Medicine, London, UK. AD - Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Dadvand, Payam AU - Dadvand P AD - ISGlobal, Doctor Aiguader 88, 08003, Barcelona, Catalonia, Spain. payam.dadvand@isglobal.org. AD - Universitat Pompeu Fabra (UPF), Barcelona, Spain. payam.dadvand@isglobal.org. AD - CIBER Epidemiología y Salud Pública (CIBERESP), Melchor Fernández Almagro, 3-5, 28029, Madrid, Spain. payam.dadvand@isglobal.org. LA - eng GR - MR/R013349/1/MRC_/Medical Research Council/United Kingdom GR - MR/V034162/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20220606 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 SB - IM MH - Accidents, Traffic MH - Cold Temperature MH - *Hot Temperature MH - Humans MH - *Motorcycles MH - Temperature PMC - PMC9553821 OTO - NOTNLM OT - Climate change OT - Iran OT - Time series OT - Traffic accident COIS- The authors declare no competing interests. EDAT- 2022/06/07 06:00 MHDA- 2022/10/14 06:00 PMCR- 2022/06/06 CRDT- 2022/06/06 23:25 PHST- 2021/10/19 00:00 [received] PHST- 2022/05/24 00:00 [accepted] PHST- 2022/06/07 06:00 [pubmed] PHST- 2022/10/14 06:00 [medline] PHST- 2022/06/06 23:25 [entrez] PHST- 2022/06/06 00:00 [pmc-release] AID - 10.1007/s11356-022-21151-8 [pii] AID - 21151 [pii] AID - 10.1007/s11356-022-21151-8 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2022 Oct;29(50):76251-76262. doi: 10.1007/s11356-022-21151-8. Epub 2022 Jun 6. PMID- 27698294 OWN - NLM STAT- MEDLINE DCOM- 20170403 LR - 20181202 IS - 2384-8553 (Electronic) IS - 0021-2571 (Linking) VI - 52 IP - 3 DP - 2016 Jul-Sep TI - The association between extreme weather conditions and work-related injuries and diseases. A systematic review of epidemiological studies. PG - 357-367 LID - 10.4415/ANN_16_03_07 [doi] AB - INTRODUCTION: The relationship between extreme temperature and population health has been well documented. Our objective was to assess the evidence supporting an association between extreme temperature and work related injuries. METHODS: We carried out a systematic search with no date limits using PubMed, the Cochrane central register of controlled trials, EMBASE, Web of Science and the internet sites of key organizations on environmental and occupational health and safety. Risk of bias was evaluated with Cochrane procedure. RESULTS: Among 270 studies selected at the first step, we analyzed 20 studies according to inclusion criteria (4 and 16 referring to extreme cold and heat temperature, respectively). DISCUSSION: Despite the relevance for policy makers and for occupational safety authorities, the associations between extreme temperature and work related injuries is seldom analyzed. The estimation of risk, the identification of specific jobs involved and the characterization of the complex mechanisms involved could help to define prevention measures. FAU - Bonafede, Michela AU - Bonafede M AD - Dipartimento di Medicina, Epidemiologia e Igiene del Lavoro e Ambientale, Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro (INAIL), Rome, Italy. FAU - Marinaccio, Alessandro AU - Marinaccio A AD - Dipartimento di Medicina, Epidemiologia e Igiene del Lavoro e Ambientale, Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro (INAIL), Rome, Italy. FAU - Asta, Federica AU - Asta F AD - Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy. FAU - Schifano, Patrizia AU - Schifano P AD - Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy. FAU - Michelozzi, Paola AU - Michelozzi P AD - Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy. FAU - Vecchi, Simona AU - Vecchi S AD - Dipartimento di Epidemiologia del Servizio Sanitario Regionale, Regione Lazio, Rome, Italy. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review PL - Italy TA - Ann Ist Super Sanita JT - Annali dell'Istituto superiore di sanita JID - 7502520 SB - IM MH - *Epidemiologic Studies MH - Humans MH - Occupational Diseases/*epidemiology MH - Occupational Health/*statistics & numerical data MH - Occupational Injuries/*epidemiology MH - Temperature MH - *Weather EDAT- 2016/10/05 06:00 MHDA- 2017/04/04 06:00 CRDT- 2016/10/05 06:00 PHST- 2016/10/05 06:00 [entrez] PHST- 2016/10/05 06:00 [pubmed] PHST- 2017/04/04 06:00 [medline] AID - 10.4415/ANN_16_03_07 [doi] PST - ppublish SO - Ann Ist Super Sanita. 2016 Jul-Sep;52(3):357-367. doi: 10.4415/ANN_16_03_07. PMID- 33029503 OWN - NLM STAT- MEDLINE DCOM- 20201016 LR - 20240802 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2020 DP - 2020 TI - Resistance Training Safety during and after the SARS-Cov-2 Outbreak: Practical Recommendations. PG - 3292916 LID - 10.1155/2020/3292916 [doi] LID - 3292916 AB - In December of 2019, there was an outbreak of a severe acute respiratory syndrome caused by the coronavirus 2 (SARS-CoV-2 or COVID-19) in China. The virus rapidly spread into the whole world causing an unprecedented pandemic and forcing governments to impose a global quarantine, entering an extreme unknown situation. The organizational consequences of quarantine/isolation are absence of organized training and competition, lack of communication among athletes and coaches, inability to move freely, lack of adequate sunlight exposure, and inappropriate training conditions. The reduction of mobility imposed to contain the advance of the SARS-Cov-2 pandemic can negatively affect the physical condition and health of individuals leading to muscle atrophy, progressive loss of muscle strength, and reductions in neuromuscular and mechanical capacities. Resistance training (RT) might be an effective tool to counteract these adverse consequences. RT is considered an essential part of an exercise program due to its numerous health and athletic benefits. However, in the face of the SARS-Cov-2 outbreak, many people might be concerned with safety issues regarding its practice, especially in indoor exercise facilities, such as gyms and fitness centers. These concerns might be associated with RT impact in the immune system, respiratory changes, and contamination due to equipment sharing and agglomeration. In this current opinion article, we provide insights to address these issues to facilitate the return of RT practices under the new logistical and health challenges. We understand that RT can be adapted to allow its performance with measures adopted to control coronavirus outbreak such that the benefits would largely overcome the potential risks. The article provides some practical information to help on its implementation. CI - Copyright © 2020 Paulo Gentil et al. FAU - Gentil, Paulo AU - Gentil P AUID- ORCID: 0000-0003-2459-4977 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. AD - Liga de Hipertensão Arterial, Universidade Federal de Goiás, Goiânia, Brazil. FAU - de Lira, Claudio Andre Barbosa AU - de Lira CAB AUID- ORCID: 0000-0001-5749-6877 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. FAU - Souza, Daniel AU - Souza D AUID- ORCID: 0000-0002-2721-1778 AD - Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brazil. FAU - Jimenez, Alfonso AU - Jimenez A AUID- ORCID: 0000-0001-5295-9668 AD - GO fit LAB, Ingesport, Madrid, Spain. AD - Advanced Wellbeing Research Centre, Sheffield Hallam University, Sheffield, UK. AD - Centre for Sport Studies, King Juan Carlos University, Madrid, Spain. FAU - Mayo, Xian AU - Mayo X AUID- ORCID: 0000-0002-4143-701X AD - GO fit LAB, Ingesport, Madrid, Spain. AD - Centre for Sport Studies, King Juan Carlos University, Madrid, Spain. FAU - de Fátima Pinho Lins Gryschek, Anna Luiza AU - de Fátima Pinho Lins Gryschek AL AUID- ORCID: 0000-0001-5012-5977 AD - Departamento de Enfermagem em Saúde Coletiva da Escola de Enfermagem da Universidade de São Paulo, São Paulo, Brazil. FAU - Pereira, Erica Gomes AU - Pereira EG AD - Departamento de Enfermagem em Saúde Coletiva da Escola de Enfermagem da Universidade de São Paulo, São Paulo, Brazil. FAU - Alcaraz, Pedro AU - Alcaraz P AUID- ORCID: 0000-0002-9792-6656 AD - Research Center for High Performance Sport, UCAM, Murcia, Spain. AD - Faculty of Sport Sciences, UCAM, Murcia, Spain. FAU - Bianco, Antonino AU - Bianco A AUID- ORCID: 0000-0001-8334-6581 AD - Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy. FAU - Paoli, Antonio AU - Paoli A AUID- ORCID: 0000-0003-0474-4229 AD - Department of Biomedical Sciences, Physiological Laboratory, University of Padova, Padova, Italy. FAU - Papeschi, Julio AU - Papeschi J AD - Instituto Valorize, Vitória, Brazil. FAU - Carnevali Junior, Luiz Carlos AU - Carnevali Junior LC AD - Centro Universitário UniFMU, São Paulo, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20200923 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Betacoronavirus MH - COVID-19 MH - China/epidemiology MH - Coronavirus Infections/*epidemiology/physiopathology/transmission MH - Disinfection/methods MH - Humans MH - Immune System/physiopathology MH - *Pandemics/prevention & control MH - Pneumonia, Viral/*epidemiology/physiopathology/transmission MH - Resistance Training/*adverse effects/instrumentation/*methods MH - Respiratory System/physiopathology MH - Risk Factors MH - SARS-CoV-2 MH - Safety PMC - PMC7532374 COIS- LCCJ is a scientific director for Instituto Smartfit. PG has a share in Academia Malhart The authors report no conflict of interest. EDAT- 2020/10/09 06:00 MHDA- 2020/10/21 06:00 PMCR- 2020/09/23 CRDT- 2020/10/08 05:34 PHST- 2020/05/28 00:00 [received] PHST- 2020/08/05 00:00 [revised] PHST- 2020/09/11 00:00 [accepted] PHST- 2020/10/08 05:34 [entrez] PHST- 2020/10/09 06:00 [pubmed] PHST- 2020/10/21 06:00 [medline] PHST- 2020/09/23 00:00 [pmc-release] AID - 10.1155/2020/3292916 [doi] PST - epublish SO - Biomed Res Int. 2020 Sep 23;2020:3292916. doi: 10.1155/2020/3292916. eCollection 2020. PMID- 31437407 OWN - NLM STAT- MEDLINE DCOM- 20200319 LR - 20200319 IS - 0001-5458 (Print) IS - 0001-5458 (Linking) VI - 119 IP - 6 DP - 2019 Dec TI - Safety and outcomes of laparoscopic cholecystectomy in the extremely elderly: a systematic review and meta-analysis. PG - 349-356 LID - 10.1080/00015458.2019.1658356 [doi] AB - Background: Gallstones are a common cause of morbidity in the elderly. Operative treatment is often avoided due to concerns about poor outcomes but the evidence for this is unclear. We aim to consolidate available evidence assessing laparoscopic cholecystectomy outcomes in the extreme elderly (>80s) compared to younger patients. Methods: Studies comparing laparoscopic cholecystectomy in >80s with younger patients were considered. Total complications, mortality, conversion, bile duct injury, and length of stay were compared between the two groups. Results: Twelve studies including 366,522 patients were included. They were of moderate overall quality. The elderly group had more complicated gallbladder disease and also had more co-morbidities and a higher ASA grade. The risk of morbidity was lower in the younger group (RR 0.58 (95% CI 0.58-0.59)) with a slightly lower risk of conversion (RR 0.96 (0.94-0.98)) Length of stay was significantly longer for the elderly patients. Differences in mortality and bile duct injury were non-significant in all but one study. Conclusion: Laparoscopic cholecystectomy is safe and effective in the extreme elderly. Higher complication rates are predominantly related to increased co-morbidities and more complex gallbladder disease. Patients should be carefully selected, and cholecystectomy performed at an earlier stage to minimize these problems. FAU - Lord, Amy C AU - Lord AC AUID- ORCID: 0000-0001-5579-6171 AD - Department of General Surgery, Croydon University Hospital , London , UK. FAU - Hicks, Georgina AU - Hicks G AUID- ORCID: 0000-0002-7518-8947 AD - Department of General Surgery, Croydon University Hospital , London , UK. FAU - Pearce, Belinda AU - Pearce B AD - Department of General Surgery, Royal Hampshire Hospital , Winchester , UK. FAU - Tanno, Lulu AU - Tanno L AD - Department of General Surgery, University Hospital Southampton , Southampton , UK. FAU - Pucher, P H AU - Pucher PH AD - Department of Surgery, Portsmouth Hospitals NHS Trust , Portsmouth , UK. LA - eng PT - Comparative Study PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20190902 PL - England TA - Acta Chir Belg JT - Acta chirurgica Belgica JID - 0370571 SB - IM MH - Age Factors MH - Aged, 80 and over MH - Bile Ducts/injuries MH - Cholecystectomy, Laparoscopic/*adverse effects/mortality/*statistics & numerical data MH - Conversion to Open Surgery/statistics & numerical data MH - Gallbladder Diseases/*surgery MH - Humans MH - Treatment Outcome OTO - NOTNLM OT - Gallstones OT - elderly OT - laparoscopic cholecystectomy EDAT- 2019/08/23 06:00 MHDA- 2020/03/20 06:00 CRDT- 2019/08/23 06:00 PHST- 2019/08/23 06:00 [pubmed] PHST- 2020/03/20 06:00 [medline] PHST- 2019/08/23 06:00 [entrez] AID - 10.1080/00015458.2019.1658356 [pii] AID - 10.1080/00015458.2019.1658356 [doi] PST - ppublish SO - Acta Chir Belg. 2019 Dec;119(6):349-356. doi: 10.1080/00015458.2019.1658356. Epub 2019 Sep 2. PMID- 37878925 OWN - NLM STAT- MEDLINE DCOM- 20231027 LR - 20231027 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 28 IP - 10 DP - 2023 Oct TI - Work conditions and biosafety of health professionals and invisible health workers in the context of COVID-19 in Brazil. PG - 2809-2822 LID - S1413-81232023001002809 [pii] LID - 10.1590/1413-812320232810.10072023 [doi] AB - The present article addresses the work conditions in health in the context of the COVID-19 pandemic in Brazil. This is a cross-sectional study that used data from the surveys "Working conditions of healthcare professionals in the context of Covid-19 in Brazil" and "Invisible healthcare workers: work conditions and mental health in the context of Covid-19 in Brazil", seeking to better understand the working conditions and biosafety of these two distinct and socially unequal professional contingents. Data analysis proves that work conditions were extremely affected due to inadequate infrastructures, strenuous work, biosecurity at risk, exhaustion, fear of contamination and death, strong signs of physical and mental exhaustion, among workers. It also points out the discrimination and inequalities of social rights and professional development that mark the worlds of work highlighted in the surveys, emphasizing the profound inequalities that exist in Brazil and in its regions. It concludes by showing the importance of formulating public policies within the scope of work management in SUS, which ensures the protection, appreciation and reduction of inequalities pointed out in this article. FAU - Machado, Maria Helena AU - Machado MH AUID- ORCID: 0000-0002-5209-2424 AD - Centro de Estudos Estratégicos (CEE), Escola Nacional de Saúde Pública (ENSP), Fundação Oswaldo Cruz (Fiocruz). R. Leopoldo Bulhões 1480, Manguinhos. 21041-210 Rio de Janeiro RJ Brasil. helenamachado06@gmail.com. FAU - Coelho, Maria Carlota de Rezende AU - Coelho MCR AUID- ORCID: 0000-0002-4556-5107 AD - Hospital Universitário da Universidade Federal do Espírito Santo (UFES). Vitória ES Brasil. FAU - Pereira, Everson Justino AU - Pereira EJ AUID- ORCID: 0000-0002-4389-306X AD - Núcleo de Estudos e Pesquisas em Recursos Humanos em Saúde (NERHUS), ENSP, Fiocruz. Rio de Janeiro RJ Brasil. FAU - Telles, Alexandre Oliveira AU - Telles AO AUID- ORCID: 0000-0001-6351-5966 AD - Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ). Rio de Janeiro RJ Brasil. FAU - Soares Neto, Joaquim José AU - Soares Neto JJ AUID- ORCID: 0000-0001-6319-1041 AD - Universidade de Brasília (UnB). Brasília DF Brasil. FAU - Ximenes Neto, Francisco Rosemiro Guimarães AU - Ximenes Neto FRG AUID- ORCID: 0000-0002-7905-9990 AD - Curso de Enfermagem, Universidade Estadual Vale do Acaraú (UVA). Sobral CE Brasil. FAU - Guimarães-Teixeira, Eleny AU - Guimarães-Teixeira E AUID- ORCID: 0000-0003-0477-3062 AD - Departamento de Clínica Médica, Escola de Medicina, Fundação Técnico Educacional Souza Marques (FTESM). Rio de Janeiro RJ Brasil. FAU - Bembele, João Niquice AU - Bembele JN AUID- ORCID: 0000-0002-0533-8321 AD - Departamento de Formação e Pesquisa, Direcção Provincial de Saúde de Maputo. Maputo Moçambique. FAU - Silva, Luciana Guedes da AU - Silva LGD AUID- ORCID: 0000-0002-5909-3462 AD - Universidade de Brasília (UnB). Brasília DF Brasil. FAU - Vargas, Filipe Leonel AU - Vargas FL AUID- ORCID: 0000-0002-7698-9260 AD - Coordenação de Comunicação Institucional (CCI), ENSP, Fiocruz. Rio de Janeiro RJ Brasil. LA - por LA - eng PT - Journal Article TT - Condições de trabalho e biossegurança dos profissionais de saúde e trabalhadores invisíveis da saúde no contexto da COVID-19 no Brasil. DEP - 20230628 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Humans MH - *COVID-19 MH - SARS-CoV-2 MH - Pandemics MH - Brazil/epidemiology MH - Containment of Biohazards MH - Cross-Sectional Studies MH - Health Personnel/psychology EDAT- 2023/10/25 18:42 MHDA- 2023/10/27 06:42 CRDT- 2023/10/25 15:24 PHST- 2022/10/20 00:00 [received] PHST- 2023/06/01 00:00 [accepted] PHST- 2023/10/27 06:42 [medline] PHST- 2023/10/25 18:42 [pubmed] PHST- 2023/10/25 15:24 [entrez] AID - S1413-81232023001002809 [pii] AID - 10.1590/1413-812320232810.10072023 [doi] PST - ppublish SO - Cien Saude Colet. 2023 Oct;28(10):2809-2822. doi: 10.1590/1413-812320232810.10072023. Epub 2023 Jun 28. PMID- 31489228 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2072-1439 (Print) IS - 2077-6624 (Electronic) IS - 2072-1439 (Linking) VI - 11 IP - Suppl 12 DP - 2019 Aug TI - Role and safety of fundoplication in esophageal disease and dysmotility syndromes. PG - S1610-S1617 LID - 10.21037/jtd.2019.06.62 [doi] AB - Gastroesophageal reflux disease (GERD) is quite prevalent worldwide, especially in the western hemisphere. The pathophysiology of GERD is complex, involving an incompetent esophagogastric junction (EGJ) as an anti-reflux barrier, as well as other co-morbid conditions such as gastroparesis, hiatal herniation or hyper acid secretion. Esophageal dysmotility is also frequently encountered in GERD, further contributing to the disease in the form of fragmented peristalsis, ineffective esophageal motility (IEM) or the more severe aperistalsis. The latter is quite common in systemic connective tissue disorders such as scleroderma. The main stay treatment of GERD is pharmacologic with proton pump inhibitors (PPI), with surgical fundoplication offered to patients who are not responsive to medications or would like to discontinue them for medical or other reasons. The presence of esophageal dysmotility that can worsen or create dysphagia can potentially influence the choice of fundoplication (partial or complete), or whether it is even possible. Most of the existing literature demonstrates that fundoplication may be safe in the setting of ineffective or weak peristalsis, and that post-operative dysphagia cannot be reliably predicted by pre-operative manometry parameters. In cases of complete aperistalsis (scleroderma-like esophagus), partial fundoplication can be offered in select patients who exhibit prominent reflux symptoms after a comprehensive multidisciplinary evaluation. Roux-en-Y gastric bypass is an alternative to fundoplication in patients with this extreme form of esophageal dysmotility, after careful consideration of the nutritional status. FAU - Bakhos, Charles T AU - Bakhos CT AD - Department of Thoracic Medicine and Surgery, Section of Gastroenterology, Temple University Hospital, Philadelphia, PA, USA. FAU - Petrov, Roman V AU - Petrov RV AD - Department of Thoracic Medicine and Surgery, Section of Gastroenterology, Temple University Hospital, Philadelphia, PA, USA. FAU - Parkman, Henry P AU - Parkman HP AD - Department of Medicine, Section of Gastroenterology, Temple University Hospital, Philadelphia, PA, USA. FAU - Malik, Zubair AU - Malik Z AD - Department of Medicine, Section of Gastroenterology, Temple University Hospital, Philadelphia, PA, USA. FAU - Abbas, Abbas E AU - Abbas AE AD - Department of Thoracic Medicine and Surgery, Section of Gastroenterology, Temple University Hospital, Philadelphia, PA, USA. LA - eng PT - Journal Article PT - Review PL - China TA - J Thorac Dis JT - Journal of thoracic disease JID - 101533916 PMC - PMC6702396 OTO - NOTNLM OT - Manometry OT - dysphagia OT - esophagus OT - reflux OT - surgery COIS- Conflicts of Interest: The authors have no conflicts of interest to declare. EDAT- 2019/09/07 06:00 MHDA- 2019/09/07 06:01 PMCR- 2019/08/01 CRDT- 2019/09/07 06:00 PHST- 2019/09/07 06:00 [entrez] PHST- 2019/09/07 06:00 [pubmed] PHST- 2019/09/07 06:01 [medline] PHST- 2019/08/01 00:00 [pmc-release] AID - jtd-11-S12-S1610 [pii] AID - 10.21037/jtd.2019.06.62 [doi] PST - ppublish SO - J Thorac Dis. 2019 Aug;11(Suppl 12):S1610-S1617. doi: 10.21037/jtd.2019.06.62. PMID- 35265329 OWN - NLM STAT- MEDLINE DCOM- 20220311 LR - 20240824 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 12 DP - 2022 TI - Safety in fragile, conflict-affected, and vulnerable settings: An evidence scanning approach for identifying patient safety interventions. PG - 04018 LID - 10.7189/jogh.12.04018 [doi] LID - 04018 AB - BACKGROUND: The number of people living in fragile, conflict-affected, and vulnerable (FCV) settings is growing rapidly and attention to achieving universal health coverage must be accompanied by sufficient focus on the safety of care for universal access to be meaningful. Healthcare workers in these settings are working under extreme conditions, often with insufficient contextualized evidence to support decision-making. Recognising the relative paucity of, and methodological issues in gathering evidence from these settings, the evidence scanning described in this paper considered which patient safety interventions might offer the 'better bet', eg, the most effective and appropriate intervention in FCV settings. METHODS: An evidence scanning approach was used to examine the literature. The search was limited to FCV settings and low-income settings as defined by the World Bank, but if a systematic review included a mix of evidence from FCV/low income settings, as well as low-middle income settings, it was included. The search was conducted in English and limited to studies published from 2003 onwards, utilising Google Scholar as a publicly accessible database and further review of the grey literature, with specific attention to the outputs of non-governmental organisations. The search and subsequent analysis were completed between April and June 2020. RESULTS: The majority of studies identified related to strengthening infection prevention and control which was also found to be the 'better bet' intervention that could generalise to other settings, be most feasible to implement, and most effective for improving patient care and associated outcomes. Other prioritized interventions include risk management, with contributing elements such as reporting, audits, and death review processes. CONCLUSIONS: Infection prevention and control interventions dominate in the literature for multiple reasons including strength of evidence, acceptability, feasibility, and impact on patient and health worker well-being. However, there is an urgent need to further develop the evidence base, specialist knowledge, and field guidance on a range of other patient safety interventions such as education and training, patient identification, subject specific safety actions, and risk management. CI - Copyright © 2022 by the Journal of Global Health. All rights reserved. FAU - O'Brien, Niki AU - O'Brien N AD - Institute of Global Health Innovation, Imperial College London, London, UK. FAU - Shaw, Alexandra AU - Shaw A AD - NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London, UK. FAU - Flott, Kelsey AU - Flott K AD - NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London, UK. FAU - Leatherman, Sheila AU - Leatherman S AD - UNC Gillings School of Global Public Health, University of North Carolina, North Carolina, USA. FAU - Durkin, Mike AU - Durkin M AD - NIHR Imperial Patient Safety Translational Research Centre, Imperial College London, London, UK. LA - eng PT - Journal Article PT - Systematic Review DEP - 20220226 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - *Health Personnel/education MH - Humans MH - *Patient Safety PMC - PMC8876158 COIS- Competing interests: The authors completed the ICMJE Unified Competing Interest form (available upon request from the corresponding author), and declare no conflicts of interest. EDAT- 2022/03/11 06:00 MHDA- 2022/03/12 06:00 PMCR- 2022/02/26 CRDT- 2022/03/10 05:45 PHST- 2022/03/10 05:45 [entrez] PHST- 2022/03/11 06:00 [pubmed] PHST- 2022/03/12 06:00 [medline] PHST- 2022/02/26 00:00 [pmc-release] AID - jogh-12-04018 [pii] AID - 10.7189/jogh.12.04018 [doi] PST - epublish SO - J Glob Health. 2022 Feb 26;12:04018. doi: 10.7189/jogh.12.04018. eCollection 2022. PMID- 19551548 OWN - NLM STAT- MEDLINE DCOM- 20090903 LR - 20090624 IS - 1545-9632 (Electronic) IS - 1545-9624 (Linking) VI - 6 IP - 9 DP - 2009 Sep TI - Climate change and occupational safety and health: establishing a preliminary framework. PG - 542-54 LID - 10.1080/15459620903066008 [doi] AB - The relationship between global climate change and occupational safety and health has not been extensively characterized. To begin such an effort, it may be useful to develop a framework for identifying how climate change could affect the workplace; workers; and occupational morbidity, mortality, and injury. This article develops such a framework based on a review of the published scientific literature from 1988-2008 that includes climatic effects, their interaction with occupational hazards, and their manifestation in the working population. Seven categories of climate-related hazards are identified: (1) increased ambient temperature, (2) air pollution, (3) ultraviolet exposure, (4) extreme weather, (5) vector-borne diseases and expanded habitats, (6) industrial transitions and emerging industries; and (7) changes in the built environment. This review indicates that while climate change may result in increasing the prevalence, distribution, and severity of known occupational hazards, there is no evidence of unique or previously unknown hazards. However, such a possibility should not be excluded, since there is potential for interactions of known hazards and new conditions leading to new hazards and risks. FAU - Schulte, Paul A AU - Schulte PA AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. PSchulte@cdc.gov FAU - Chun, HeeKyoung AU - Chun H LA - eng PT - Journal Article PT - Review PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - *Climate MH - Communicable Diseases/transmission MH - Disasters MH - *Greenhouse Effect MH - Heat Stress Disorders/epidemiology MH - Humans MH - Occupational Exposure MH - *Occupational Health MH - Risk Assessment MH - Risk Factors MH - Ultraviolet Rays MH - Weather RF - 136 EDAT- 2009/06/25 09:00 MHDA- 2009/09/04 06:00 CRDT- 2009/06/25 09:00 PHST- 2009/06/25 09:00 [entrez] PHST- 2009/06/25 09:00 [pubmed] PHST- 2009/09/04 06:00 [medline] AID - 912624827 [pii] AID - 10.1080/15459620903066008 [doi] PST - ppublish SO - J Occup Environ Hyg. 2009 Sep;6(9):542-54. doi: 10.1080/15459620903066008. PMID- 31423527 OWN - NLM STAT- MEDLINE DCOM- 20200622 LR - 20200622 IS - 1930-6180 (Electronic) IS - 1084-2020 (Linking) VI - 60 IP - 1 DP - 2019 Dec 31 TI - Laboratory Safety, Biosecurity, and Responsible Animal Use. PG - 24-33 LID - 10.1093/ilar/ilz012 [doi] AB - Research with animals presents a wide array of hazards, some of which overlap those in the in vitro research laboratory. The challenge for environmental health and safety professionals when making their recommendations and performing the risk assessment is to balance worker safety with animal safety/welfare. The care and husbandry of animals require procedures and tasks that create aerosols and involve metabolized chemicals and a variety of physical hazards that must be assessed in addition to the research related risks, all while balancing the biosecurity of the facility and NIH animal care requirements. Detailed communication between health and safety, research, and animal care teams is essential to understand how to mitigate the risks that are present and if modifications need to be made as the experiments and processes progress and change over time. Additionally, the backgrounds and education levels of the persons involved in animal research and husbandry can be quite broad; the training programs created need to reflect this. Active learning and hands-on training are extremely beneficial for all staff involved in this field. Certain areas of research, such as infectious disease research in high- and maximum-containment (biosafety level 3 and 4) facilities, present challenges that are not seen in lower containment or chemical exposure experiments. This paper reviews potential hazards and mitigation strategies and discusses unique challenges for safety at all biosafety levels. CI - © The Author(s) 2019. Published by Oxford University Press on behalf of the National Academy of Sciences. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - McCormick-Ell, Jessica AU - McCormick-Ell J AD - Rutgers, The State University of New Jersey, Newark, New Jersey. FAU - Connell, Nancy AU - Connell N AD - Johns Hopkins Center for Health Security, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. LA - eng PT - Journal Article PL - England TA - ILAR J JT - ILAR journal JID - 9516416 SB - IM MH - Animal Experimentation/*standards MH - Animals MH - Containment of Biohazards/*methods MH - Risk Assessment OTO - NOTNLM OT - animal OT - biosafety OT - biosafety level three OT - hazard OT - risk assessment EDAT- 2019/08/20 06:00 MHDA- 2020/06/23 06:00 CRDT- 2019/08/20 06:00 PHST- 2018/06/08 00:00 [received] PHST- 2019/05/07 00:00 [revised] PHST- 2019/06/03 00:00 [accepted] PHST- 2019/08/20 06:00 [pubmed] PHST- 2020/06/23 06:00 [medline] PHST- 2019/08/20 06:00 [entrez] AID - 5550511 [pii] AID - 10.1093/ilar/ilz012 [doi] PST - ppublish SO - ILAR J. 2019 Dec 31;60(1):24-33. doi: 10.1093/ilar/ilz012. PMID- 36257855 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230410 LR - 20230411 IS - 1879-2022 (Electronic) IS - 0019-0578 (Linking) VI - 135 DP - 2023 Apr TI - NMPC-based controller for vehicle longitudinal and lateral stability enhancement under extreme driving conditions. PG - 509-523 LID - S0019-0578(22)00496-7 [pii] LID - 10.1016/j.isatra.2022.09.038 [doi] AB - This paper proposes a real-time NMPC-based controller for four-wheel independent motor-drive electric vehicles to improve vehicle longitudinal and lateral stability under extreme driving conditions. First, considering the interactive and highly coupled longitudinal-lateral vehicle dynamics, a combined-slip tire model is applied to develop the stability controller on low friction coefficient surfaces. Second, the wheel slip ratios and slip angles are selected as the virtual control inputs of the NMPC controller to concurrently achieve three main control objectives: Slip control, lateral stability control, and handling performance improvement. Simultaneously, multiple safety constraints are contained. Then, based on the dynamic relationships between the longitudinal tire force and virtual control inputs, the wheel slip ratios and slip angles obtained from the NMPC controller are converted into additional torques acting directly on each wheel. Finally, the control performance is investigated by co-simulation with MATLAB/Simulink and CarSim, and a hardware-in-the-loop simulation system. The effect of uncertainties on control performance is also verified. The results show that the proposed controller can rapidly solve the optimization problem, and vehicle overall stability are efficiently enhanced under extreme conditions. The robustness of the controller is proved with uncertainties on the road adhesion coefficient and vehicle mass. CI - Copyright © 2022 ISA. Published by Elsevier Ltd. All rights reserved. FAU - Li, Zihan AU - Li Z AD - State Key Laboratory of Automotive Simulation and Control, Jilin University, Changchun 130022, China; the Department of Control Science and Engineering, School of Communication Engineering, Jilin University, Changchun 130025, China. Electronic address: zihanl20@mails.jlu.edu.cn. FAU - Wang, Ping AU - Wang P AD - the Department of Control Science and Engineering, School of Communication Engineering, Jilin University, Changchun 130025, China. Electronic address: wangping12@jlu.edu.cn. FAU - Cai, Shuo AU - Cai S AD - State Key Laboratory of Automotive Simulation and Control, Jilin University, Changchun 130022, China; the Department of Control Science and Engineering, School of Communication Engineering, Jilin University, Changchun 130025, China. Electronic address: caishuo19@mails.jlu.edu.cn. FAU - Hu, Xiao AU - Hu X AD - State Key Laboratory of Automotive Simulation and Control, Jilin University, Changchun 130022, China; the Department of Control Science and Engineering, School of Communication Engineering, Jilin University, Changchun 130025, China. Electronic address: huxiao19@mails.jlu.edu.cn. FAU - Chen, Hong AU - Chen H AD - the Department of Control Science and Engineering, School of Communication Engineering, Jilin University, Changchun 130025, China; Clean Energy Automotive Engineering Center, Tongji University, Shanghai 201804, China. Electronic address: chenhong2019@tongji.edu.cn. LA - eng PT - Journal Article DEP - 20221006 PL - United States TA - ISA Trans JT - ISA transactions JID - 0374750 SB - IM OTO - NOTNLM OT - Extreme driving conditions OT - Nonlinear model predictive control OT - Tire combined-slip characteristics OT - Torque conversion OT - Vehicle stability control COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/10/19 06:00 MHDA- 2022/10/19 06:01 CRDT- 2022/10/18 22:03 PHST- 2020/09/08 00:00 [received] PHST- 2022/07/08 00:00 [revised] PHST- 2022/09/24 00:00 [accepted] PHST- 2022/10/19 06:01 [medline] PHST- 2022/10/19 06:00 [pubmed] PHST- 2022/10/18 22:03 [entrez] AID - S0019-0578(22)00496-7 [pii] AID - 10.1016/j.isatra.2022.09.038 [doi] PST - ppublish SO - ISA Trans. 2023 Apr;135:509-523. doi: 10.1016/j.isatra.2022.09.038. Epub 2022 Oct 6. PMID- 35592361 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2451-9936 (Electronic) IS - 2451-9936 (Linking) VI - 26 DP - 2022 Jun TI - Conjunctival leiomyosarcoma. PG - 101580 LID - 10.1016/j.ajoc.2022.101580 [doi] LID - 101580 AB - PURPOSE: Leiomyosarcoma (LMS) is a mesenchymal neoplasm with smooth muscle differentiation, being considered one of the most common soft tissue sarcomas. However, it rarely affects the eye, and when it does, it is usually located in the orbit, being extremely rare in the conjunctiva. OBSERVATIONS: We report a case of a 45 years old male patient, with a recurrent rapid growing conjunctival mass on the temporal limbus of his left eye, which was excised, and the anatomopathological report was suggestive of a grade 1 leiomyosarcoma. Since the lesion was recurrent, we decided to perform an extended enucleation for treating this condition. Nevertheless, the patient is being followed up to 30 months, with systemic metastasis screening, showing no other lesions or recurrences. CONCLUSIONS AND IMPORTANCE: Conjunctival leiomyosarcoma is an extremely rare ocular tumor, which can be clinically indistinguishable from other conditions such as squamous cell carcinoma, so, biopsy is essential. Albeit there is no standard treatment, complete surgical removal with safety margins is mandatory. CI - © 2022 The Author(s). FAU - Gameiro Filho, Aluisio Rosa AU - Gameiro Filho AR AD - Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo (Unifesp - EPM), R. Botucatu, 822 - Vila Clementino, São Paulo, SP, 04023-062, Brazil. FAU - Castello Branco, Ana Marisa Pires AU - Castello Branco AMP AD - Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo (Unifesp - EPM), R. Botucatu, 822 - Vila Clementino, São Paulo, SP, 04023-062, Brazil. FAU - Rigueiro, Moacyr Pezati AU - Rigueiro MP AD - Pathology Department, Universidade Federal de São Paulo (Unifesp -EPM), R. Botucatu, 720 - Vila Clementino, São Paulo, SP, 04023-062, Brazil. FAU - Morales, Melina Correia AU - Morales MC AD - Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo (Unifesp - EPM), R. Botucatu, 822 - Vila Clementino, São Paulo, SP, 04023-062, Brazil. FAU - Belfort, Rubens N AU - Belfort RN AD - Ophthalmology and Visual Sciences Department, Universidade Federal de São Paulo (Unifesp - EPM), R. Botucatu, 822 - Vila Clementino, São Paulo, SP, 04023-062, Brazil. LA - eng PT - Case Reports PT - Journal Article DEP - 20220511 PL - United States TA - Am J Ophthalmol Case Rep JT - American journal of ophthalmology case reports JID - 101679941 PMC - PMC9112115 OTO - NOTNLM OT - Conjunctiva OT - Eye OT - Leiomyosarcoma OT - Sarcoma OT - Soft tissue tumours OT - Tumor EDAT- 2022/05/21 06:00 MHDA- 2022/05/21 06:01 PMCR- 2022/05/11 CRDT- 2022/05/20 02:23 PHST- 2021/02/18 00:00 [received] PHST- 2022/04/18 00:00 [revised] PHST- 2022/05/05 00:00 [accepted] PHST- 2022/05/20 02:23 [entrez] PHST- 2022/05/21 06:00 [pubmed] PHST- 2022/05/21 06:01 [medline] PHST- 2022/05/11 00:00 [pmc-release] AID - S2451-9936(22)00326-7 [pii] AID - 101580 [pii] AID - 10.1016/j.ajoc.2022.101580 [doi] PST - epublish SO - Am J Ophthalmol Case Rep. 2022 May 11;26:101580. doi: 10.1016/j.ajoc.2022.101580. eCollection 2022 Jun. PMID- 37177686 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230514 LR - 20230515 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 23 IP - 9 DP - 2023 May 4 TI - Dam Safety Evaluation Method after Extreme Load Condition Based on Health Monitoring and Deep Learning. LID - 10.3390/s23094480 [doi] LID - 4480 AB - The safety operation of dams after extreme load is an important frontier research topic in the field of dam engineering. The dam health monitoring provides a reliable data basis for a safety evaluation after extreme loads. This study proposes a novel data-driven fusion model for a dam safety evaluation after extreme load based on monitoring data derived by sensors. First, the relationship between dam environmental quantity and effect quantity is deeply excavated based on bidirectional long short-term memory (BiLSTM) network, which is a deeply improved LSTM model. Aiming at the parameter optimization problem of BiLSTM model, sparrow search algorithm (SSA), which is an advanced optimization algorithm, is integrated. Second, conducting the constructed SSA-BiLSTM model to estimate the change law of dam effect quantity after the extreme load. Finally, the Mann-Whitney U-test theory is introduced to establish the evaluation criterion of the dam safety state. Project case shows that the multiple quantitative prediction accuracy evaluation indicators of the proposed method are significantly superior to the comparison method, with mean absolute percentage error (MAPE) and mean absolute error (MAE) values decreasing by 30.5% and 27.8%, respectively, on average. The proposed model can accurately diagnose the dam safety state after the extreme load compared with on-site inspection results of the engineering department, which provides a new method for dam safety evaluation. FAU - Song, Jintao AU - Song J AD - School of Water Resources and Hydro-Electric Engineering, Xi'an University of Technology, Xi'an 710048, China. FAU - Liu, Yunhe AU - Liu Y AD - School of Water Resources and Hydro-Electric Engineering, Xi'an University of Technology, Xi'an 710048, China. FAU - Yang, Jie AU - Yang J AD - School of Water Resources and Hydro-Electric Engineering, Xi'an University of Technology, Xi'an 710048, China. LA - eng GR - 52039008/National Natural Science Foundation of China/ GR - 52109166/National Natural Science Foundation of China/ PT - Journal Article DEP - 20230504 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC10181591 OTO - NOTNLM OT - dam OT - deep learning OT - extreme load OT - monitoring model OT - safety evaluation OT - structural health monitoring COIS- The authors declare no conflict of interest. EDAT- 2023/05/13 15:13 MHDA- 2023/05/13 15:14 PMCR- 2023/05/04 CRDT- 2023/05/13 01:39 PHST- 2023/04/03 00:00 [received] PHST- 2023/04/28 00:00 [revised] PHST- 2023/05/01 00:00 [accepted] PHST- 2023/05/13 15:14 [medline] PHST- 2023/05/13 15:13 [pubmed] PHST- 2023/05/13 01:39 [entrez] PHST- 2023/05/04 00:00 [pmc-release] AID - s23094480 [pii] AID - sensors-23-04480 [pii] AID - 10.3390/s23094480 [doi] PST - epublish SO - Sensors (Basel). 2023 May 4;23(9):4480. doi: 10.3390/s23094480. PMID- 37960552 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231117 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 23 IP - 21 DP - 2023 Oct 31 TI - Extraction and Application of Hydraulic Support Safety Valve Characteristic Parameters Based on Roof Pressure Data. LID - 10.3390/s23218853 [doi] LID - 8853 AB - The safety valves of powered supports control the maximum working resistance, and their statuses must be known to ensure the safety of both the support and the overlying strata. However, the inspection of powered support valves involves manual or semiautomated operations, the costs of which are high. In this study, an extreme point extraction method was developed for the determination of the characteristic parameters of safety valves using roof pressure data, and a safety valve state monitoring module was constructed. Using the longwall face of 0116(3)06 with top coal caving in the Mindong Mine as an example, the characteristic parameters of the safety valves were extracted, including the peak, reseating, and blowdown pressures, as well as the recovery and unloading durations. The results of the field tests showed the following: (1) The amplitude threshold method based on extreme points can be used to accurately extract characteristic parameters, and the distribution of the characteristic parameters of the safety valves follows either a Gaussian or an exponential distribution. (2) The mining pressure analysis results, derived from the characteristic parameters, closely align with the in situ mining pressure observations. This method can be used for the online monitoring of safety valve conditions, increasing the operational efficiency and quality of safety valve inspections. FAU - Xing, Keke AU - Xing K AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. AD - Artificial Intelligence Research Institude, China University of Mining and Technology, Xuzhou 221116, China. FAU - Cheng, Jingyi AU - Cheng J AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. FAU - Wan, Zhijun AU - Wan Z AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. FAU - Sun, Xin AU - Sun X AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. FAU - Yan, Wanzi AU - Yan W AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. FAU - Lv, Jiakun AU - Lv J AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. FAU - Xue, Minti AU - Xue M AD - School of Mines, China University of Mining and Technology, Xuzhou 221116, China. LA - eng GR - 2022XSCX21/Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20231031 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC10649293 OTO - NOTNLM OT - amplitude threshold method OT - roof pressure data OT - safety valve OT - state monitoring COIS- The authors declare no conflict of interest. EDAT- 2023/11/14 06:43 MHDA- 2023/11/14 06:44 PMCR- 2023/10/31 CRDT- 2023/11/14 02:20 PHST- 2023/09/19 00:00 [received] PHST- 2023/10/15 00:00 [revised] PHST- 2023/10/25 00:00 [accepted] PHST- 2023/11/14 06:44 [medline] PHST- 2023/11/14 06:43 [pubmed] PHST- 2023/11/14 02:20 [entrez] PHST- 2023/10/31 00:00 [pmc-release] AID - s23218853 [pii] AID - sensors-23-08853 [pii] AID - 10.3390/s23218853 [doi] PST - epublish SO - Sensors (Basel). 2023 Oct 31;23(21):8853. doi: 10.3390/s23218853. PMID- 35868144 OWN - NLM STAT- MEDLINE DCOM- 20220809 LR - 20220809 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 174 DP - 2022 Sep TI - A reliability-based approach to evaluate the lateral safety of truck platoon under extreme weather conditions. PG - 106775 LID - S0001-4575(22)00210-X [pii] LID - 10.1016/j.aap.2022.106775 [doi] AB - The truck platoon is one of the most promising connected and autonomous vehicle (CAV) technologies that can reduce fuel consumption and emission, enhance traffic safety, and increase roadway capacity. It is predicted to become mainstream in the next decade. Therefore, it is imperative to fully investigate the safety issues of the truck platoon before its large-scale deployment. However, studies on the lateral safety of the truck platoon under extreme weather, especially crosswinds are still lacking. To fill such a research gap, the current study contributes to the literature by proposing a reliability-based framework to evaluate the safety of the truck platoon regarding incursion into neighboring lanes due to extreme weather, especially crosswinds. The proposed approach involved three main steps: (1) the computational fluid dynamics (CFD) simulation of the aerodynamics of the truck platoon; (2) the truck platoon driving simulation under crosswind; and (3) the advanced response surface model development and the reliability analysis. Four main factors regarding lateral safety of the platoon were considered: wind speed, road friction coefficients, driving speed, and inter-vehicle spacing. The maximum lateral displacement (MLD) was chosen as a measure of lateral safety. The results showed that there was a significant difference between the aerodynamics of a single truck and that of the truck platoon vehicles and the inter-vehicle spacing between trucks within the truck platoon barely influenced the MLD. The MLD was largest for the leading truck as compared to those of the following trucks. The inter-vehicle spacing didn't have a significant influence on MLD when the inter-vehicle spacing is shorter than 1.5 times of the truck length, while the other factors impacted the MLD significantly. In addition, the support vector regression with the radial basis function outperformed the other response surface functions. Based on reliability analysis, the risk level of the truck platoon was quantified using the safety index, and the impact of contributing factors towards the safety index of the truck platoon was also evaluated. This study confirmed that the proposed framework could be applied to evaluate the lateral safety of the truck platoon. The findings provide important practical implications for the decision-making of transportation management agencies and tailored countermeasures in the CAV) environment. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Xiaoxiang, Ma AU - Xiaoxiang M AD - National Engineering Laboratory of Integrated Transportation Big Data Application Technology, School of Transportation and Logistics, Southwest Jiaotong University, Chengdu 611756, China. Electronic address: xiaoxiang.ma@swjtu.edu.cn. FAU - Zhimin, Tu AU - Zhimin T AD - Guangdong Communication Planning & Design Institute Group Co Ltd, Guangzhou 510507, China. Electronic address: tuzhimin@ghdi.cn. FAU - Feng, Chen AU - Feng C AD - The Key Laboratory of Road and Traffic Engineering, Ministry of Education, Tongji University, Shanghai 201804, China. Electronic address: fengchen@tongji.edu.cn. LA - eng PT - Journal Article DEP - 20220719 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/prevention & control MH - *Automobile Driving MH - *Extreme Weather MH - Humans MH - Motor Vehicles MH - Reproducibility of Results MH - Safety MH - Weather OTO - NOTNLM OT - Crosswind OT - Reliability OT - Support vector regression OT - Traffic safety OT - Truck platoon EDAT- 2022/07/23 06:00 MHDA- 2022/08/10 06:00 CRDT- 2022/07/22 18:20 PHST- 2022/02/04 00:00 [received] PHST- 2022/06/26 00:00 [revised] PHST- 2022/07/12 00:00 [accepted] PHST- 2022/07/23 06:00 [pubmed] PHST- 2022/08/10 06:00 [medline] PHST- 2022/07/22 18:20 [entrez] AID - S0001-4575(22)00210-X [pii] AID - 10.1016/j.aap.2022.106775 [doi] PST - ppublish SO - Accid Anal Prev. 2022 Sep;174:106775. doi: 10.1016/j.aap.2022.106775. Epub 2022 Jul 19. PMID- 28598687 OWN - NLM STAT- MEDLINE DCOM- 20171106 LR - 20181202 IS - 1744-7666 (Electronic) IS - 1465-6566 (Linking) VI - 18 IP - 12 DP - 2017 Aug TI - Lomitapide for the treatment of hypercholesterolemia. PG - 1261-1268 LID - 10.1080/14656566.2017.1340941 [doi] AB - Homozygous familial hypercholesterolemia (HoFH) is a serious rare inherited condition that leads to extremely elevated levels of low density lipoprotein cholesterol (LDL-C), and predisposes affected individuals to high risk of atherosclerotic vascular disease. Traditional therapies are largely ineffective in managing the hypercholesterolemia in these patients; diet and regular LDL-apheresis are the mainstays of management. Lomitapide is an inhibitor of microsomal triglyceride transfer protein (MTP) that blocks the assembly of metabolic precursors of LDL particles. Lomitapide has been approved for use in the HoFH population. Areas covered: This article explores the basic properties of lomitapide, including its pharmacodynamic, pharmacokinetic and metabolic profiles. It also reports the current market status of lomitapide and its close competitors. Trials of lomitapide are also briefly reviewed as well as the safety and tolerability of the drug. Expert opinion: Lomitapide has been recently approved for use in HoFH, a population that has been traditionally very difficult to effectively manage. While lomitapide has some safety concerns, including gastrointestinal symptoms and potential hepatotoxicity, and has yet to prove long term efficacy on hard cardiovascular endpoints, it does represent an attractive treatment option for a small group of patients who, until now, had very limited available effective therapies. FAU - Berberich, Amanda J AU - Berberich AJ AD - a Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry , Western University , London , Canada. FAU - Hegele, Robert A AU - Hegele RA AD - a Department of Medicine and Robarts Research Institute, Schulich School of Medicine and Dentistry , Western University , London , Canada. LA - eng PT - Journal Article PT - Review DEP - 20170730 PL - England TA - Expert Opin Pharmacother JT - Expert opinion on pharmacotherapy JID - 100897346 RN - 0 (Anticholesteremic Agents) RN - 0 (BMS201038) RN - 0 (Benzimidazoles) RN - 0 (Carrier Proteins) RN - 0 (Cholesterol, LDL) RN - 0 (microsomal triglyceride transfer protein) SB - IM MH - Anticholesteremic Agents/pharmacokinetics/*therapeutic use MH - Atherosclerosis/prevention & control MH - Benzimidazoles/pharmacokinetics/*therapeutic use MH - Carrier Proteins/antagonists & inhibitors MH - Cholesterol, LDL/blood MH - Clinical Trials as Topic MH - Genotype MH - Humans MH - Hypercholesterolemia/blood/*drug therapy/genetics OTO - NOTNLM OT - Hyperlipoproteinemia type IIA OT - apolipoprotein B OT - atherosclerosis OT - human genetic disease OT - low-density lipoprotein OT - low-density lipoprotein receptor OT - microsomal triglyceride transfer protein EDAT- 2017/06/10 06:00 MHDA- 2017/11/07 06:00 CRDT- 2017/06/10 06:00 PHST- 2017/06/10 06:00 [pubmed] PHST- 2017/11/07 06:00 [medline] PHST- 2017/06/10 06:00 [entrez] AID - 10.1080/14656566.2017.1340941 [doi] PST - ppublish SO - Expert Opin Pharmacother. 2017 Aug;18(12):1261-1268. doi: 10.1080/14656566.2017.1340941. Epub 2017 Jul 30. PMID- 27991978 OWN - NLM STAT- MEDLINE DCOM- 20180314 LR - 20190517 IS - 1680-5348 (Electronic) IS - 1020-4989 (Print) IS - 1020-4989 (Linking) VI - 40 IP - 3 DP - 2016 Sep TI - Worker health and safety and climate change in the Americas: issues and research needs. PG - 192-197 LID - S1020-49892016000900192 [pii] AB - SYNOPSIS This report summarizes and discusses current knowledge on the impact that climate change can have on occupational safety and health (OSH), with a particular focus on the Americas. Worker safety and health issues are presented on topics related to specific stressors (e.g., temperature extremes), climate associated impacts (e.g., ice melt in the Arctic), and a health condition associated with climate change (chronic kidney disease of non-traditional etiology). The article discusses research needs, including hazards, surveillance, and risk assessment activities to better characterize and understand how OSH may be associated with climate change events. Also discussed are the actions that OSH professionals can take to ensure worker health and safety in the face of climate change. FAU - Kiefer, Max AU - Kiefer M AD - United States Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, United States of America. FAU - Rodríguez-Guzmán, Julietta AU - Rodríguez-Guzmán J AD - Pan American Health Organization, Washington, DC, United States. FAU - Watson, Joanna AU - Watson J AD - United States Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Western States Division, United States of America. FAU - van Wendel de Joode, Berna AU - van Wendel de Joode B AD - Central American Institute for Studies on Toxic Substances, Universidad Nacional, Heredia, Costa Rica. FAU - Mergler, Donna AU - Mergler D AD - Center for Interdisciplinary Research on Health, Well-being, Environment and Society, University of Quebec at Montreal, Montreal, Canada. FAU - da Silva, Agnes Soares AU - da Silva AS AD - Pan American Health Organization, Washington, DC, United States. LA - eng GR - CC999999/Intramural CDC HHS/United States PT - Journal Article PL - United States TA - Rev Panam Salud Publica JT - Revista panamericana de salud publica = Pan American journal of public health JID - 9705400 SB - IM MH - Americas MH - Arctic Regions MH - *Climate Change MH - Extreme Heat MH - Humans MH - Ice Cover MH - *Occupational Health MH - Risk Assessment PMC - PMC5176103 MID - NIHMS825138 COIS- Conflicts of Interest: None declared. EDAT- 2016/12/20 06:00 MHDA- 2018/03/15 06:00 PMCR- 2017/09/01 CRDT- 2016/12/20 06:00 PHST- 2016/04/07 00:00 [received] PHST- 2016/06/02 00:00 [accepted] PHST- 2016/12/20 06:00 [entrez] PHST- 2016/12/20 06:00 [pubmed] PHST- 2018/03/15 06:00 [medline] PHST- 2017/09/01 00:00 [pmc-release] AID - S1020-49892016000900192 [pii] PST - ppublish SO - Rev Panam Salud Publica. 2016 Sep;40(3):192-197. PMID- 2700138 OWN - NLM STAT- MEDLINE DCOM- 19900717 LR - 20191029 IS - 0950-3552 (Print) IS - 0950-3552 (Linking) VI - 3 IP - 4 DP - 1989 Dec TI - Premenstrual syndrome. PG - 687-704 AB - The term premenstrual syndrome is often used to describe several clinical conditions. Only a full history covering not only reproductive but also psychological and social factors, combined with daily diaries which are kept prospectively for at least two months, can help clarify the problems the patient experiences. As it is the timing rather than the type of symptoms which is essential to a diagnosis, diaries are used to assess symptoms, make a diagnosis and monitor the effectiveness of therapy. Patients with premenstrual syndrome should therefore always keep a diary and bring it to every consultation. We do not know if patients complaining of premenstrual syndrome are at one extreme of a spectrum disorder or if they are a 'specific group'. Such patients may have classical premenstrual syndrome, perimenstrual distress, benign idiopathic oedema, dysmenorrhoea, cyclical benign breast disease or mood symptoms which are not significantly related to the menstrual cycle. There are many aetiological theories--biological, psychological, environmental and social, the syndrome being a complex psychosomatic disorder. For appropriate management an accurate diagnostic formation is required. Reassurance, stress management techniques, an improvement in general mental and physical well-being, information and education are the mainstays of therapy. Symptomatic relief of symptoms is often helpful. Many other managements have been tried with the aim of correcting the underlying aetiological case. These include vitamins, prostaglandin inhibitors and endocrine therapies. As the disorder is long-term, the safety of treatments should be carefully considered. FAU - Sampson, G A AU - Sampson GA LA - eng PT - Journal Article PT - Review PL - England TA - Baillieres Clin Obstet Gynaecol JT - Bailliere's clinical obstetrics and gynaecology JID - 8710782 SB - IM MH - Female MH - Humans MH - *Premenstrual Syndrome/psychology RF - 67 EDAT- 1989/12/01 00:00 MHDA- 1989/12/01 00:01 CRDT- 1989/12/01 00:00 PHST- 1989/12/01 00:00 [pubmed] PHST- 1989/12/01 00:01 [medline] PHST- 1989/12/01 00:00 [entrez] AID - 10.1016/s0950-3552(89)80060-4 [doi] PST - ppublish SO - Baillieres Clin Obstet Gynaecol. 1989 Dec;3(4):687-704. doi: 10.1016/s0950-3552(89)80060-4. PMID- 34852193 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211216 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 13 IP - 49 DP - 2021 Dec 15 TI - Ultralight Biomass Aerogels with Multifunctionality and Superelasticity Under Extreme Conditions. PG - 59231-59242 LID - 10.1021/acsami.1c17216 [doi] AB - Biomass aerogels are highly attractive candidates in various applications due to their intrinsic merits of high strength, high porosity, biodegradability, and renewability. However, under low-temperature harsh conditions, biomass aerogels suffer from weakened mechanical properties, become extremely brittle, and lose functionality. Herein, we report a multifunctional biomass aerogel with lamella nanostructures (∼1 μm) fabricated from cellulose nanofibers (∼200 nm) and gelatin, showing outstanding elasticity from room temperature to ultralow temperatures (repeatedly bent, twisted, or compressed in liquid nitrogen). The resultant aerogel exhibits excellent organic solvent absorption, thermal infrared stealth, and thermal insulation performance in both normal and extreme environments. Even at dry ice temperature (-78 °C), the aerogel can selectively and repeatedly absorb organic solvents in the same way as room temperature with high capacities (90-177 g/g). Excellent heat insulation and infrared stealth performances are achieved in a wide temperature range of -196 to 80 °C. Further, this aerogel combines with the advantages of ultralow density (∼6 mg/cm(3)), biodegradability, flame retardancy, and performance stability, making it a perfect candidate for multifunctional applications under harsh conditions. This work greatly broadens application temperature windows of biomass aerogels and sheds light on the development of mechanically robust biomass aerogels for various applications under extreme conditions. FAU - Li, Shu-Liang AU - Li SL AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Wang, Juan AU - Wang J AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Zhao, Hai-Bo AU - Zhao HB AUID- ORCID: 0000-0002-5455-2965 AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Cheng, Jin-Bo AU - Cheng JB AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Zhang, Ai-Ning AU - Zhang AN AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Wang, Ting AU - Wang T AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Cao, Min AU - Cao M AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Fu, Teng AU - Fu T AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. FAU - Wang, Yu-Zhong AU - Wang YZ AD - The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu 610064, China. LA - eng PT - Journal Article DEP - 20211201 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - biomass aerogel OT - extreme conditions OT - infrared stealth OT - solvent absorption OT - superelasticity OT - thermal insulation EDAT- 2021/12/02 06:00 MHDA- 2021/12/02 06:01 CRDT- 2021/12/01 20:06 PHST- 2021/12/02 06:00 [pubmed] PHST- 2021/12/02 06:01 [medline] PHST- 2021/12/01 20:06 [entrez] AID - 10.1021/acsami.1c17216 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2021 Dec 15;13(49):59231-59242. doi: 10.1021/acsami.1c17216. Epub 2021 Dec 1. PMID- 17487258 OWN - NLM STAT- MEDLINE DCOM- 20070625 LR - 20070509 IS - 0008-4212 (Print) IS - 0008-4212 (Linking) VI - 85 IP - 1 DP - 2007 Jan TI - The public health and safety consequences of sleep disorders. PG - 179-83 AB - Sleep deprivation and medical disorders of sleep are common in today's society and have significant public health implications. In this article, we address 3 specific issues related to the public health and safety consequences of sleep disorders. First, we review data that has linked sleep restriction to a variety of adverse physiologic and long-term health outcomes including all-cause mortality, diabetes, and cardiovascular disease. Second, we will review recent data that has demonstrated that therapy for obstructive sleep apnea (the most common respiratory disorder of sleep) is an extremely efficient use of healthcare resources (in terms of dollars spent per quality adjusted life year gained), and compares favorably with other commonly funded medical therapies. Finally, we will review data that illustrate the potential adverse patient and occupational safety impacts of the extreme work schedules of housestaff (physicians in training). FAU - Sigurdson, Krista AU - Sigurdson K AD - Sleep Disorders Program, UBC Hospital, 2211 Westbrook Mall, Vancouver, BC V6T 2B5, Canada. FAU - Ayas, Najib T AU - Ayas NT LA - eng PT - Journal Article PT - Review PL - Canada TA - Can J Physiol Pharmacol JT - Canadian journal of physiology and pharmacology JID - 0372712 SB - IM MH - Canada/epidemiology MH - Cardiovascular Diseases/etiology MH - Clinical Competence MH - Continuous Positive Airway Pressure/*economics MH - Cost-Benefit Analysis MH - Diabetes Mellitus/etiology MH - Fatigue MH - Humans MH - *Internship and Residency MH - Medical Errors MH - *Public Health MH - Quality-Adjusted Life Years MH - Sleep Apnea, Obstructive/*complications/economics/*therapy MH - Sleep Deprivation/*complications/economics/etiology/mortality/therapy MH - Treatment Outcome MH - Work Schedule Tolerance MH - Workload RF - 37 EDAT- 2007/05/10 09:00 MHDA- 2007/06/26 09:00 CRDT- 2007/05/10 09:00 PHST- 2007/05/10 09:00 [pubmed] PHST- 2007/06/26 09:00 [medline] PHST- 2007/05/10 09:00 [entrez] AID - y06-095 [pii] AID - 10.1139/y06-095 [doi] PST - ppublish SO - Can J Physiol Pharmacol. 2007 Jan;85(1):179-83. doi: 10.1139/y06-095. PMID- 32487012 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20210215 IS - 1366-5847 (Electronic) IS - 0014-0139 (Linking) VI - 63 IP - 10 DP - 2020 Oct TI - Logistic transport in extreme environments: the evolution of risk and safety management over 27 years of the polar traverse. PG - 1257-1270 LID - 10.1080/00140139.2020.1777329 [doi] AB - In this article we seek to explain how safety mechanisms and risks evolve over time. The article focuses on a sociotechnical system, that of a polar traverse (a transport operation in a polar environment). In the study spanning a period of 27 years data were collected with ethnographic participative observations on three of the 56 traverses already achieved. Activities were traced from the whole 1398 daily reports and scale models of the convoy vehicles were used to reconstruct events during the traverses. Self-confrontation interviews were also conducted. A traverse feedback process was carried out which revealed that (1) whereas proactive safety is aimed at maintaining the continuous improvement of a system, reactive safety makes it possible to maintain the system's level of safety; (2) the development of redundancy and mixed technology contribute positively to the safety system. Improvements made to the safety system, its dynamics, and embodied resilience are discussed as well as the study limitations and implications. Practitioner summary: This article seeks to understand how safety has been ensured in logistical transport in extreme conditions in a case study extending over a period of more than 27 years. The study investigates how risks and safety mechanisms have evolved and the benefits of developing a traverse feedback process to improve safety. Abbreviations: IPEV: French Polar Institute (Institut Polaire Francais); DDU: Dumont d'Urville (French coastal antarctic station). FAU - Villemain, Aude AU - Villemain A AD - CIAMS Laboratory, COST Collegium Science & Technology, University of Orleans, Paris-Saclay, Orleans, France. AD - Research Centre on Work and Development (CRTD), Ergonomics Team, CNAM, Paris, France. FAU - Godon, Patrice AU - Godon P AD - Département logistique polaire, French Polar Institute (IPEV) Paul Emile Victor, Plouzane, France. LA - eng PT - Journal Article DEP - 20200618 PL - England TA - Ergonomics JT - Ergonomics JID - 0373220 SB - IM MH - Aged MH - Antarctic Regions MH - *Extreme Environments MH - Humans MH - Male MH - Risk Assessment MH - Safety Management/*methods/*trends MH - Transportation/*methods OTO - NOTNLM OT - Proactive-reactive safety OT - dynamics OT - extreme situations OT - risks OT - system improvement EDAT- 2020/06/04 06:00 MHDA- 2021/02/16 06:00 CRDT- 2020/06/04 06:00 PHST- 2020/06/04 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2020/06/04 06:00 [entrez] AID - 10.1080/00140139.2020.1777329 [doi] PST - ppublish SO - Ergonomics. 2020 Oct;63(10):1257-1270. doi: 10.1080/00140139.2020.1777329. Epub 2020 Jun 18. PMID- 24812526 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140624 LR - 20220316 IS - 1179-1365 (Print) IS - 1179-1365 (Electronic) IS - 1179-1365 (Linking) VI - 6 DP - 2014 TI - Patient safety and minimizing risk with insulin administration - role of insulin degludec. PG - 55-67 LID - 10.2147/DHPS.S59566 [doi] AB - Diabetes is a lifelong condition requiring ongoing medical care and patient self-management. Exogenous insulin therapy is essential in type 1 diabetes and becomes a necessity in patients with longstanding type 2 diabetes who fail to achieve optimal control with lifestyle modification, oral agents, and glucagon-like peptide 1-based therapy. One of the risks that hinders insulin use is hypoglycemia. Optimal insulin therapy should therefore minimize the risk of hypoglycemia while improving glycemic control. Insulin degludec (IDeg) is a novel basal insulin that, following subcutaneous injection, assembles into a depot of soluble multihexamer chains. These subsequently release IDeg monomers that are absorbed at a slow and steady rate into the circulation, with the terminal half-life of IDeg being ~25 hours. Thus, it requires only once-daily dosing unlike other basal insulin preparations that often require twice-daily dosing. Despite its long half-life, once-daily IDeg does not cause accumulation of insulin in the circulation after reaching steady state. IDeg once a day will produce a steady-state profile with a lower peak:trough ratio than other basal insulins. In clinical trials, this profile translates into a lower frequency of nocturnal hypoglycemia compared with insulin glargine, as well as an ability to allow some flexibility in dose timing without compromising efficacy and safety. Indeed, a study that tested the extremes of dosing intervals of 8 and 40 hours showed no detriment in either glycemic control or hypoglycemic frequency versus insulin glargine given at the same time each day. While extreme flexibility in dose timing is not recommended, these findings are reassuring. This may be particularly beneficial to elderly patients, patients with learning difficulties, or others who have to rely on health-care professionals for their daily insulin injections. Further studies are required to confirm whether this might benefit adherence to treatment, reduce long-term hypoglycemia or reduce diabetes-related complications. FAU - Aye, Myint M AU - Aye MM AD - Hull Royal Infirmary, Michael White Diabetes Centre, Hull, UK. FAU - Atkin, Stephen L AU - Atkin SL AD - Weill Cornell Medical College Qatar, Qatar Foundation, Doha, Qatar. LA - eng PT - Journal Article PT - Review DEP - 20140430 PL - New Zealand TA - Drug Healthc Patient Saf JT - Drug, healthcare and patient safety JID - 101544775 PMC - PMC4010638 OTO - NOTNLM OT - basal insulin OT - diabetes OT - hypoglycemia OT - safety EDAT- 2014/05/09 06:00 MHDA- 2014/05/09 06:01 PMCR- 2014/04/30 CRDT- 2014/05/10 06:00 PHST- 2014/05/10 06:00 [entrez] PHST- 2014/05/09 06:00 [pubmed] PHST- 2014/05/09 06:01 [medline] PHST- 2014/04/30 00:00 [pmc-release] AID - dhps-6-055 [pii] AID - 10.2147/DHPS.S59566 [doi] PST - epublish SO - Drug Healthc Patient Saf. 2014 Apr 30;6:55-67. doi: 10.2147/DHPS.S59566. eCollection 2014. PMID- 35422934 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240826 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 14 IP - 3 DP - 2022 TI - Proposed protocol for the investigation of the safety and efficacy of the COVID-19 vaccine for patients with psychosis, with pilot safety findings from a Chinese psychiatrist's self-experiment. PG - 2063-2072 AB - We present a study protocol designed to test the safety and efficacy of the 2019 coronavirus disease (COVID-19) vaccine in patients with major psychotic disease. A secondary objective is to investigate optional vaccination methods for these patients. In a self-experiment, a Chinese psychiatrist examined the safety and efficacy of the COVID-19 vaccine under clinical use of typical antipsychotic agents and sedatives (olanzapine, duloxetine, and diazepam). For patients with extremely drug-resistant conditions, the safety of the COVID-19 vaccine under electroconvulsive therapy was also investigated. The entire study process was recorded on high-definition video. This clinical study protocol is, to our knowledge, the first of its kind. Our findings will shed new light on the protection of patients with psychotic diseases from COVID-19 infection. The protocol was registered at Chinese clinical trial registry (www.chictr.org.cn, ChiCTR2100051297). CI - AJTR Copyright © 2022. FAU - Lin, Chongguang AU - Lin C AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Fang, Tao AU - Fang T AD - Key Laboratory of Real Time Tracing of Brain Circuit of Neurology and Psychiatry (RTBNP_Lab), Tianjin Medical University Affiliated Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated to Nankai University, Tianjin Fourth Center Hospital Tianjin 300140, China. FAU - Chen, Jiayue AU - Chen J AD - Key Laboratory of Real Time Tracing of Brain Circuit of Neurology and Psychiatry (RTBNP_Lab), Tianjin Medical University Affiliated Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated to Nankai University, Tianjin Fourth Center Hospital Tianjin 300140, China. FAU - Li, Qianchen AU - Li Q AD - Department of Pharmacology, First Hospital/First Clinical Medical College of Hebei Medical University Shijiazhuang 050000, Hebei, China. FAU - Yang, Weiliang AU - Yang W AD - Key Laboratory of Psychiatric-Neuroimaging-Genetics and Comorbidity of Schizophrenia (PNGC_Lab), Tianjin Anding Hospital, Tianjin Mental Health Center Tianjin 300300, China. FAU - Yao, Cong AU - Yao C AD - Key Laboratory of Psychiatric-Neuroimaging-Genetics and Comorbidity of Schizophrenia (PNGC_Lab), Tianjin Anding Hospital, Tianjin Mental Health Center Tianjin 300300, China. FAU - Wang, Lina AU - Wang L AD - Key Laboratory of Psychiatric-Neuroimaging-Genetics and Comorbidity of Schizophrenia (PNGC_Lab), Tianjin Anding Hospital, Tianjin Mental Health Center Tianjin 300300, China. FAU - Sun, Yun AU - Sun Y AD - Key Laboratory of Psychiatric-Neuroimaging-Genetics and Comorbidity of Schizophrenia (PNGC_Lab), Tianjin Anding Hospital, Tianjin Mental Health Center Tianjin 300300, China. FAU - Cai, Ziyao AU - Cai Z AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Ping, Jing AU - Ping J AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Chen, Ce AU - Chen C AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Cheng, Langlang AU - Cheng L AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Zhu, Jinjing AU - Zhu J AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Chen, Guangdong AU - Chen G AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Shan, Peiwei AU - Shan P AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Chen, Chunmian AU - Chen C AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Lin, Xiaodong AU - Lin X AD - Department of Psychiatry, Key Laboratory of Comorbidity, Wenzhou Seventh Peoples Hospital Wenzhou 325000, Zhejiang, China. FAU - Tian, Hongjun AU - Tian H AD - Key Laboratory of Real Time Tracing of Brain Circuit of Neurology and Psychiatry (RTBNP_Lab), Tianjin Medical University Affiliated Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated to Nankai University, Tianjin Fourth Center Hospital Tianjin 300140, China. FAU - Zhuo, Chuanjun AU - Zhuo C AD - Key Laboratory of Real Time Tracing of Brain Circuit of Neurology and Psychiatry (RTBNP_Lab), Tianjin Medical University Affiliated Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated to Nankai University, Tianjin Fourth Center Hospital Tianjin 300140, China. LA - eng PT - Journal Article DEP - 20220315 PL - United States TA - Am J Transl Res JT - American journal of translational research JID - 101493030 PMC - PMC8991108 OTO - NOTNLM OT - COVID-19 vaccine OT - diazepam OT - duloxetine OT - electroconvulsive therapy OT - olanzapine OT - psychotic disease COIS- None. EDAT- 2022/04/16 06:00 MHDA- 2022/04/16 06:01 PMCR- 2022/03/15 CRDT- 2022/04/15 05:24 PHST- 2021/07/13 00:00 [received] PHST- 2022/02/08 00:00 [accepted] PHST- 2022/04/15 05:24 [entrez] PHST- 2022/04/16 06:00 [pubmed] PHST- 2022/04/16 06:01 [medline] PHST- 2022/03/15 00:00 [pmc-release] PST - epublish SO - Am J Transl Res. 2022 Mar 15;14(3):2063-2072. eCollection 2022. PMID- 38216518 OWN - NLM STAT- MEDLINE DCOM- 20240214 LR - 20240312 IS - 1574-6976 (Electronic) IS - 0168-6445 (Print) IS - 0168-6445 (Linking) VI - 48 IP - 1 DP - 2024 Jan 12 TI - Radioactive waste microbiology: predicting microbial survival and activity in changing extreme environments. LID - 10.1093/femsre/fuae001 [doi] LID - fuae001 AB - The potential for microbial activity to occur within the engineered barrier system (EBS) of a geological disposal facility (GDF) for radioactive waste is acknowledged by waste management organizations as it could affect many aspects of the safety functions of a GDF. Microorganisms within an EBS will be exposed to changing temperature, pH, radiation, salinity, saturation, and availability of nutrient and energy sources, which can limit microbial survival and activity. Some of the limiting conditions are incorporated into GDF designs for safety reasons, including the high pH of cementitious repositories, the limited pore space of bentonite-based repositories, or the high salinity of GDFs in evaporitic geologies. Other environmental conditions such as elevated radiation, temperature, and desiccation, arise as a result of the presence of high heat generating waste (HHGW). Here, we present a comprehensive review of how environmental conditions in the EBS may limit microbial activity, covering HHGW and lower heat generating waste (LHGW) in a range of geological environments. We present data from the literature on the currently recognized limits to life for each of the environmental conditions described above, and nutrient availability to establish the potential for life in these environments. Using examples where each variable has been modelled for a particular GDF, we outline the times and locations when that variable can be expected to limit microbial activity. Finally, we show how this information for multiple variables can be used to improve our understanding of the potential for microbial activity to occur within the EBS of a GDF and, more broadly, to understand microbial life in changing environments exposed to multiple extreme conditions. CI - British Geological Survey © UKRI 2024. Published by Oxford University Press on behalf of FEMS. FAU - Gregory, Simon P AU - Gregory SP AUID- ORCID: 0000-0002-3410-1390 AD - British Geological Survey, Nicker Hill, Keyworth, Nottingham NG12 5GG, United Kingdom. FAU - Mackie, Jessica R M AU - Mackie JRM AD - British Geological Survey, Nicker Hill, Keyworth, Nottingham NG12 5GG, United Kingdom. FAU - Barnett, Megan J AU - Barnett MJ AD - British Geological Survey, Nicker Hill, Keyworth, Nottingham NG12 5GG, United Kingdom. LA - eng GR - British Geological Survey/ PT - Journal Article PT - Review PL - England TA - FEMS Microbiol Rev JT - FEMS microbiology reviews JID - 8902526 RN - 0 (Radioactive Waste) SB - IM MH - *Radioactive Waste/analysis MH - *Extreme Environments MH - *Environmental Microbiology PMC - PMC10853057 OTO - NOTNLM OT - extremophiles OT - geomicrobiology OT - microbial survival OT - radioactive waste COIS- There are no conflicts of interest. EDAT- 2024/01/13 00:42 MHDA- 2024/02/10 14:42 PMCR- 2024/01/12 CRDT- 2024/01/12 22:13 PHST- 2023/07/31 00:00 [received] PHST- 2023/12/01 00:00 [revised] PHST- 2024/01/11 00:00 [accepted] PHST- 2024/02/10 14:42 [medline] PHST- 2024/01/13 00:42 [pubmed] PHST- 2024/01/12 22:13 [entrez] PHST- 2024/01/12 00:00 [pmc-release] AID - 7521301 [pii] AID - fuae001 [pii] AID - 10.1093/femsre/fuae001 [doi] PST - ppublish SO - FEMS Microbiol Rev. 2024 Jan 12;48(1):fuae001. doi: 10.1093/femsre/fuae001. PMID- 36867613 OWN - NLM STAT- MEDLINE DCOM- 20230307 LR - 20240913 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 18 IP - 3 DP - 2023 TI - Pre-slaughter, slaughter and post-slaughter practices of slaughterhouse workers in Southeast, Nigeria: Animal welfare, meat quality, food safety and public health implications. PG - e0282418 LID - 10.1371/journal.pone.0282418 [doi] LID - e0282418 AB - BACKGROUND: Pre-slaughter stress or the welfare condition of food-producing animals (FPAs) and the slaughter practices of slaughterhouse workers (SHWs) are critically important for the safety and quality of meats processed in slaughterhouses (SHs). Consequently, this study determined the pre-slaughter, slaughter, and post-slaughter (PSP) practices of SHWsin four SHs in Southeast, Nigeria; and discussed the impacts on meat quality and safety. METHODS: The PSP practices were determined by observation method. Additionally, a structured and validated closed-ended questionnaire was used to determine the knowledge of the SHWs on: the effects of poor welfare (preslaughter stress) on the quality and safety of meats produced, carcass/meat processing practices and modes of transmission of meat-borne zoonotic pathogens during carcass/meat processing. Finally, a systematic post-mortem inspection (PMI) was conducted on cattle, pigs and goats slaughtered, and economic losses accruable from condemned carcasses/meats were estimated. RESULTS: Food-producing animals were transported to the SHs or held in the lairage under inhumane conditions. A pig being conveyed to one of the SHs was seen gasping for air, as it was firmly tied on motorbike at the thoracic and abdominal regions. Fatigued cattle were forcefully dragged on the ground from the lairage to the killing floor. Cattle for slaughter were restrained, held in lateral recumbency and left groaning, due to extreme discomfort, for about one hour before slaughter. Stunning was not performed. Singed pig carcasses were dragged on the ground to the washing point. Although more than 50% of the respondents knew the modes of transmission of meat-borne zoonotic pathogens during meat processing, 71.3% of the SHWs processed carcasses on bare floor, 52.2% used same bowl of water to wash multiple carcasses while 72% did not wear personal protective equipment during meat/carcass processing. Processed meats were transported to meat shops in an unsanitary conditions, using open vans and tricycles. During the PMI, diseased carcasses/meats/organs were detected in 5.7% (83/1452), 2.1% (21/1006) and 0.8% (7/924) of the cattle, pig and goat carcasses inspected, respectively. Gross lesions pathognomonic of bovine tuberculosis, contagious bovine pleuro-pneumonia, fascioliasis and porcine cysticercosis were detected. Consequently, 391,089.2 kg of diseased meat/organs valued at 978 million Naira (235, 030 USD) were condemned. There were significant associations (p < 0.05) between educational level and the use of personal protective equipment (PPE) during slaughterhouse operations and knowledge that FPAs can harbour zoonotic pathogens (p = < 0.001) transmissible during carcass processing. Similarly, significant association was observed between working experience and use of PPE; and between geographical location of the respondents and knowledge that zoonotic pathogens in animals are transmissible during carcass processing or via the food chain. CONCLUSION: The findings show that slaughter practices of SHWs have detrimental impacts on the quality and safety of meats processed for human consumption in Southeast, Nigeria. These findings underscore the need to: improve the welfare condition of slaughter-animals, mechanise abattoir operations, train and retrain the SHWs on hygienic carcass/meat processing practices. There is a need to adopt strict enforcement of food safety laws to promote meat quality, food safety and consequently promote the health of the public. CI - Copyright: © 2023 Njoga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Njoga, Emmanuel O AU - Njoga EO AUID- ORCID: 0000-0002-2333-7584 AD - Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. FAU - Ilo, Stanley U AU - Ilo SU AD - Department of Animal Science, Faculty of Agriculture, University of Nigeria, Nsukka, Nigeria. FAU - Nwobi, Obichukwu C AU - Nwobi OC AD - Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria. FAU - Onwumere-Idolor, Onyinye S AU - Onwumere-Idolor OS AD - Department of Animal Production, Faculty of Agriculture, Delta State University of Science and Technology, Ozoro, Delta State, Nigeria. FAU - Ajibo, Festus E AU - Ajibo FE AD - Department of Animal Health and Production, Enugu State Polytechnic, Iwollo, Nigeria. FAU - Okoli, Chinwe E AU - Okoli CE AD - Department of Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria. FAU - Jaja, Ishmael F AU - Jaja IF AD - Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Johannesburg, South Africa. FAU - Oguttu, James W AU - Oguttu JW AUID- ORCID: 0000-0001-6810-4437 AD - Department of Agriculture and Animal Health, College of Agriculture and Environmental Sciences, University of South Africa, Johannesburg, South Africa. LA - eng PT - Journal Article DEP - 20230303 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Cattle MH - Humans MH - Animals MH - Swine MH - *Public Health MH - Nigeria MH - *Abattoirs MH - Animal Welfare MH - Food Safety MH - Goats PMC - PMC9983863 COIS- The authors declared that no competing interest exist. EDAT- 2023/03/04 06:00 MHDA- 2023/03/08 06:00 PMCR- 2023/03/03 CRDT- 2023/03/03 13:33 PHST- 2022/08/08 00:00 [received] PHST- 2023/02/10 00:00 [accepted] PHST- 2023/03/03 13:33 [entrez] PHST- 2023/03/04 06:00 [pubmed] PHST- 2023/03/08 06:00 [medline] PHST- 2023/03/03 00:00 [pmc-release] AID - PONE-D-22-21592 [pii] AID - 10.1371/journal.pone.0282418 [doi] PST - epublish SO - PLoS One. 2023 Mar 3;18(3):e0282418. doi: 10.1371/journal.pone.0282418. eCollection 2023. PMID- 26617374 OWN - NLM STAT- MEDLINE DCOM- 20160809 LR - 20151130 IS - 1545-1534 (Electronic) IS - 1080-6032 (Linking) VI - 26 IP - 4 Suppl DP - 2015 Dec TI - General Consideration in the History, Physical Examination, and Safety Determination. PG - S15-9 LID - S1080-6032(15)00328-2 [pii] LID - 10.1016/j.wem.2015.09.011 [doi] AB - A thorough medical history is perhaps the most important aspect when evaluating an athlete before wilderness adventure. A physical examination should follow focusing on conditions that may be affected by changes in atmospheric pressure, extremes of temperature, or altitude. This information can then be used to make safety recommendations ensuring that adventurers are able to safely enjoy participation in the wilderness pursuit of their choice. CI - Copyright © 2015. Published by Elsevier Inc. FAU - Buchanan, Jonathan AU - Buchanan J AD - Legacy Medical Group, Sports Medicine, Beaverton, Oregon (Dr Buchanan). Electronic address: jon.buchanan@icloud.com. FAU - Dexter, William AU - Dexter W AD - Maine Medical Center, Portland, Maine (Dr Dexter). FAU - Powell, Amy AU - Powell A AD - University of Utah, Salt Lake City, Utah (Dr Powell). FAU - Wright, Justin AU - Wright J AD - Texas Tech University, Lubbock, Texas (Dr Wright). LA - eng PT - Journal Article PT - Review PL - United States TA - Wilderness Environ Med JT - Wilderness & environmental medicine JID - 9505185 SB - IM MH - Athletes MH - Humans MH - Medical History Taking/*methods MH - Pediatrics MH - Physical Examination/*methods MH - Risk Assessment MH - Safety MH - Societies, Medical MH - Sports MH - Sports Medicine/*methods MH - *Wilderness OTO - NOTNLM OT - history OT - physical examination OT - safety determination OT - wilderness medicine EDAT- 2015/12/01 06:00 MHDA- 2016/08/10 06:00 CRDT- 2015/12/01 06:00 PHST- 2015/03/02 00:00 [received] PHST- 2015/06/13 00:00 [accepted] PHST- 2015/12/01 06:00 [entrez] PHST- 2015/12/01 06:00 [pubmed] PHST- 2016/08/10 06:00 [medline] AID - S1080-6032(15)00328-2 [pii] AID - 10.1016/j.wem.2015.09.011 [doi] PST - ppublish SO - Wilderness Environ Med. 2015 Dec;26(4 Suppl):S15-9. doi: 10.1016/j.wem.2015.09.011. PMID- 39534224 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241114 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 11 DP - 2024 TI - Ketogenic diet in clinical populations-a narrative review. PG - 1432717 LID - 10.3389/fmed.2024.1432717 [doi] LID - 1432717 AB - Ketogenic diet (KD) is a high-fat, low-carbohydrate (CHO) diet, designed to induce a metabolic state of ketosis in which the body metabolizes primarily lipids for energy production. Various forms of KD are being promoted as promising treatments for numerous health conditions from chronic headaches to weight-loss and even different forms of cancer and are becoming increasingly more popular. KD appears to be an efficacious approach for weight-loss, and maintenance, improved glycemia, cognitive function and cancer prognosis. However, there is a controversy regarding the safety of KD, and the potential health risks that might be associated with long-term exposure to KD. There is a gap between the acceptance and utilization of KD in individuals with health conditions and the criticism and negative attitudes toward KD by some clinicians. Many individuals choose to follow KD and are encouraged by the positive results they experience. Although the medical establishment does not endorse KD as a first line of treatment, clinicians need to be informed about KD, and offer support and medical supervision for patients who self-select to follow KD. This can ensure that within the boundaries of KD, patients will make good and healthy dietary choices and prevent clinical disengagement in extreme cases. To that end, there is an urgent need for good quality research to address the issues of long-term safety of KD in different clinical populations and for standardization of KD both in research and in the clinic. CI - Copyright © 2024 Zemer, Samaei, Yoel, Biderman and Pincu. FAU - Zemer, Alon AU - Zemer A AD - Department of Pharmacology and Clinical Biochemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel. FAU - Samaei, Shabnam AU - Samaei S AD - Department of Health and Exercise Science, University of Oklahoma, Norman, OK, United States. FAU - Yoel, Uri AU - Yoel U AD - Endocrinology Unit, Soroka University Medical Center, Beer Sheva, Israel. FAU - Biderman, Aya AU - Biderman A AD - Department of Family Medicine, Goldman Medical School, Ben-Gurion University of the Negev and Clalit Health Services, Beer Sheva, Israel. FAU - Pincu, Yair AU - Pincu Y AD - Department of Pharmacology and Clinical Biochemistry, Ben-Gurion University of the Negev, Beer Sheva, Israel. AD - Department of Health and Exercise Science, University of Oklahoma, Norman, OK, United States. AD - Harold Hamm Diabetes Center, Oklahoma City, OK, United States. LA - eng PT - Journal Article PT - Review DEP - 20241029 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC11554467 OTO - NOTNLM OT - cancer OT - diabetes OT - intractable pediatric epilepsy OT - neurodegenerative disease OT - obesity OT - very-low-carbohydrate-diet OT - weight-loss COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/11/14 03:55 MHDA- 2024/11/14 03:56 PMCR- 2024/10/29 CRDT- 2024/11/13 04:17 PHST- 2024/05/14 00:00 [received] PHST- 2024/10/14 00:00 [accepted] PHST- 2024/11/14 03:56 [medline] PHST- 2024/11/14 03:55 [pubmed] PHST- 2024/11/13 04:17 [entrez] PHST- 2024/10/29 00:00 [pmc-release] AID - 10.3389/fmed.2024.1432717 [doi] PST - epublish SO - Front Med (Lausanne). 2024 Oct 29;11:1432717. doi: 10.3389/fmed.2024.1432717. eCollection 2024. PMID- 25741935 OWN - NLM STAT- MEDLINE DCOM- 20170130 LR - 20170130 IS - 1848-6312 (Electronic) IS - 0004-1254 (Linking) VI - 66 IP - 1 DP - 2015 Mar TI - Health protection and risks for rescuers in cases of floods. PG - 9-13 LID - 10.1515/aiht-2015-66-2559 [doi] AB - Floods can pose a number of safety and health hazards for flood-affected populations and rescuers and bring risk of injuries, infections, and diseases due to exposure to pathogenic microorganisms and different biological and chemical contaminants. The risk factors and possible health consequences for the rescuers involved in evacuation and rescuing operations during the May 2014 flood crisis in Croatia are shown, as well as measures for the prevention of injuries and illnesses. In cases of extreme floods, divers play a particularly important role in rescuing and first-response activities. Rescuing in contaminated floodwaters means that the used equipment such as diving suits should be disinfected afterwards. The need for securing the implementation of minimal health and safety measures for involved rescuers is paramount. Data regarding injuries and disease occurrences among rescuers are relatively scarce, indicating the need for medical surveillance systems that would monitor and record all injuries and disease occurrences among rescuers in order to ensure sound epidemiological data. The harmful effects of flooding can be reduced by legislation, improvement of flood forecasting, establishing early warning systems, and appropriate planning and education. FAU - Janev Holcer, Nataša AU - Janev Holcer N FAU - Jeličić, Pavle AU - Jeličić P FAU - Grba Bujević, Maja AU - Grba Bujević M FAU - Važanić, Damir AU - Važanić D LA - eng PT - Journal Article PT - Review PL - Croatia TA - Arh Hig Rada Toksikol JT - Arhiv za higijenu rada i toksikologiju JID - 0373100 SB - IM MH - Croatia MH - *Emergency Responders MH - *Floods MH - Humans MH - Occupational Diseases/*prevention & control MH - Risk Factors MH - Safety Management/*methods MH - Wounds and Injuries/*prevention & control EDAT- 2015/03/06 06:00 MHDA- 2017/01/31 06:00 CRDT- 2015/03/06 06:00 PHST- 2014/07/01 00:00 [received] PHST- 2015/02/01 00:00 [accepted] PHST- 2015/03/06 06:00 [entrez] PHST- 2015/03/06 06:00 [pubmed] PHST- 2017/01/31 06:00 [medline] AID - /j/aiht.ahead-of-print/aiht-2015-66-2559/aiht-2015-66-2559.xml [pii] AID - 10.1515/aiht-2015-66-2559 [doi] PST - ppublish SO - Arh Hig Rada Toksikol. 2015 Mar;66(1):9-13. doi: 10.1515/aiht-2015-66-2559. PMID- 32816233 OWN - NLM STAT- MEDLINE DCOM- 20210414 LR - 20210414 IS - 1865-8652 (Electronic) IS - 0741-238X (Linking) VI - 37 IP - 10 DP - 2020 Oct TI - Evaluation of the Physico-Chemical and Biological Stability of SB8 (Aybintio), a Proposed Biosimilar to Bevacizumab, Under Ambient and In-Use Conditions. PG - 4308-4324 LID - 10.1007/s12325-020-01465-0 [doi] AB - INTRODUCTION: No stability data of SB8 (proposed biosimilar to bevacizumab) are available for opened vials at 2-8 °C or for unopened vials stored outside of this range. Furthermore, limited stability data are available for dilutions. Stability of unopened vials of SB8 at ambient temperature and in-use stability for opened vials as well as diluted SB8 in infusion bags were evaluated. METHODS: SB8 stability was assessed in three scenarios in the absence of light: unopened 100-mg vials 36 months after manufacture stored at 30 ± 2 °C with 65 ± 5% relative humidity for 1 month, opened 100-mg and 400-mg vials stored at 5 ± 3 °C for 72 h and diluted (1.4 mg/ml or 16.5 mg/ml in 100 ml 0.9% NaCl polyolefin bags) stored for 45 days at 5 ± 3 °C and then 3 days at 30 ± 2 °C; the United Kingdom's National Health Service protocol was used for the study design after dilution. Physicochemical stability (appearance, pH, protein concentration, size-exclusion high-performance liquid chromatography, non-reducing capillary electrophoresis-sodium dodecyl sulfate, imaged capillary isoelectric focusing), biological activity [vascular endothelial growth factor (VEGF) neutralization assay, VEGF binding assay] and potential safety impact properties (subvisible particulates, submicronic aggregation by dynamic light scattering) were determined. RESULTS: All stability-indicating criteria including those for biological activity were met for both unopened vials at ambient condition and for in-use conditions of opened vials as well as both dilutions. No noteworthy changes in terms of physicochemical stability, biological activity and properties with a potential safety impact occurred. CONCLUSION: Under the studied aspetic extreme conditions, SB8 was stable. Our data may support advanced SB8 preparation and may help prevent SB8 wastage because of exceptional temperature excursions or unused product. Sterility assurance is the responsibility of the user and is of utmost importance when opened or diluted SB8 is not immediately used. FAU - Park, Dongkuk AU - Park D AD - Quality Evaluation Team, Samsung Bioepis Co., Ltd., 107, Cheomdan-daero, Yeonsu-gu, Incheon, 21987, Republic of Korea. FAU - Kim, Jihyun AU - Kim J AD - Quality Evaluation Team, Samsung Bioepis Co., Ltd., 107, Cheomdan-daero, Yeonsu-gu, Incheon, 21987, Republic of Korea. FAU - Yun, Jihoon AU - Yun J AD - Quality Evaluation Team, Samsung Bioepis Co., Ltd., 107, Cheomdan-daero, Yeonsu-gu, Incheon, 21987, Republic of Korea. FAU - Park, Su Jin AU - Park SJ AD - Quality Evaluation Team, Samsung Bioepis Co., Ltd., 107, Cheomdan-daero, Yeonsu-gu, Incheon, 21987, Republic of Korea. sujin8171.park@samsung.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200820 PL - United States TA - Adv Ther JT - Advances in therapy JID - 8611864 RN - 0 (Biosimilar Pharmaceuticals) RN - 0 (Vascular Endothelial Growth Factor A) RN - 2S9ZZM9Q9V (Bevacizumab) MH - Bevacizumab MH - *Biosimilar Pharmaceuticals MH - Drug Stability MH - Drug Storage MH - Humans MH - State Medicine MH - Vascular Endothelial Growth Factor A OTO - NOTNLM OT - Ambient temperature OT - Avastin OT - Aybintio OT - Bevacizumab OT - Biosimilar OT - In-use OT - Oncology OT - SB8 OT - Stability OT - Storage EDAT- 2020/08/21 06:00 MHDA- 2021/04/15 06:00 CRDT- 2020/08/21 06:00 PHST- 2020/07/06 00:00 [received] PHST- 2020/08/21 06:00 [pubmed] PHST- 2021/04/15 06:00 [medline] PHST- 2020/08/21 06:00 [entrez] AID - 10.1007/s12325-020-01465-0 [pii] AID - 10.1007/s12325-020-01465-0 [doi] PST - ppublish SO - Adv Ther. 2020 Oct;37(10):4308-4324. doi: 10.1007/s12325-020-01465-0. Epub 2020 Aug 20. PMID- 26842343 OWN - NLM STAT- MEDLINE DCOM- 20161220 LR - 20220311 IS - 2196-5412 (Electronic) IS - 2196-5412 (Linking) VI - 3 IP - 1 DP - 2016 Mar TI - An Overview of Occupational Risks From Climate Change. PG - 13-22 LID - 10.1007/s40572-016-0081-4 [doi] AB - Changes in atmosphere and temperature are affecting multiple environmental indicators from extreme heat events to global air quality. Workers will be uniquely affected by climate change, and the occupational impacts of major shifts in atmospheric and weather conditions need greater attention. Climate change-related exposures most likely to differentially affect workers in the USA and globally include heat, ozone, polycyclic aromatic hydrocarbons, other chemicals, pathogenic microorganisms, vector-borne diseases, violence, and wildfires. Epidemiologic evidence documents a U-, J-, or V-shaped relationship between temperature and mortality. Whereas heat-related morbidity and mortality risks are most evident in agriculture, many other outdoor occupational sectors are also at risk, including construction, transportation, landscaping, firefighting, and other emergency response operations. The toxicity of chemicals change under hyperthermic conditions, particularly for pesticides and ozone. Combined with climate-related changes in chemical transport and distribution, these interactions represent unique health risks specifically to workers. Links between heat and interpersonal conflict including violence require attention because they pose threats to the safety of emergency medicine, peacekeeping and humanitarian relief, and public safety professionals. Recommendations for anticipating how US workers will be most susceptible to climate change include formal monitoring systems for agricultural workers; modeling scenarios focusing on occupational impacts of extreme climate events including floods, wildfires, and chemical spills; and national research agenda setting focusing on control and mitigation of occupational susceptibility to climate change. FAU - Applebaum, Katie M AU - Applebaum KM AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - Graham, Jay AU - Graham J AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - Gray, George M AU - Gray GM AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - LaPuma, Peter AU - LaPuma P AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - McCormick, Sabrina A AU - McCormick SA AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - Northcross, Amanda AU - Northcross A AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. FAU - Perry, Melissa J AU - Perry MJ AD - Department of Environmental and Occupational Health, Milken School of Public Health, George Washington University, 950 New Hampshire Avenue Northwest, Washington, DC, 20052, USA. mperry@gwu.edu. LA - eng PT - Journal Article PT - Review PL - Switzerland TA - Curr Environ Health Rep JT - Current environmental health reports JID - 101629387 RN - 0 (Environmental Pollutants) RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - 66H7ZZK23N (Ozone) SB - IM MH - *Climate Change MH - Communicable Diseases/*etiology MH - *Disease Outbreaks MH - Environmental Pollutants/*adverse effects MH - Hot Temperature/adverse effects MH - Humans MH - Occupational Exposure/*adverse effects MH - *Occupational Health MH - Ozone/adverse effects MH - Polycyclic Aromatic Hydrocarbons/adverse effects OTO - NOTNLM OT - Climate change OT - Heat OT - Occupational risks OT - Other chemicals OT - Ozone OT - Pathogenic microorganisms OT - Polycyclic aromatic hydrocarbons OT - Vector-borne diseases OT - Violence and wildfires EDAT- 2016/02/05 06:00 MHDA- 2016/12/21 06:00 CRDT- 2016/02/05 06:00 PHST- 2016/02/05 06:00 [entrez] PHST- 2016/02/05 06:00 [pubmed] PHST- 2016/12/21 06:00 [medline] AID - 10.1007/s40572-016-0081-4 [pii] AID - 10.1007/s40572-016-0081-4 [doi] PST - ppublish SO - Curr Environ Health Rep. 2016 Mar;3(1):13-22. doi: 10.1007/s40572-016-0081-4. PMID- 34281624 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210723 IS - 2197-1714 (Print) IS - 2197-1714 (Electronic) IS - 2197-1714 (Linking) VI - 8 IP - 1 DP - 2021 Jul 19 TI - The risks of warm nights and wet days in the context of climate change: assessing road safety outcomes in Boston, USA and Santo Domingo, Dominican Republic. PG - 47 LID - 10.1186/s40621-021-00342-w [doi] LID - 47 AB - BACKGROUND: There remains a dearth of cross-city comparisons on the impact of climate change through extreme temperature and precipitation events on road safety. We examined trends in traffic fatalities, injuries and property damage associated with high temperatures and heavy rains in Boston (USA) and Santo Domingo (Dominican Republic). METHODS: Official publicly available data on daily traffic outcomes and weather conditions during the warm season (May to September) were used for Boston (2002-2015) and Santo Domingo (2013-2017). Daily maximum temperatures and mean precipitations for each city were considered for classifying hot days, warm days, and warm nights, and wet, very wet, and extremely wet days. Time-series analyses were used to assess the relationship between temperature and precipitation and daily traffic outcomes, using a quasi-Poisson regression. RESULTS: In Santo Domingo, the presence of a warm night increased traffic fatalities with a rate ratio (RR) of 1.31 (95% CI [confidence interval]: 1.00,1.71). In Boston, precipitation factors (particularly, extremely wet days) were associated with increments in traffic injuries (RR 1.25, 95% CI: 1.18, 1.32) and property damages (RR 1.42, 95% CI: 1.33, 1.51). CONCLUSION: During the warm season, mixed associations between weather conditions and traffic outcomes were found across Santo Domingo and Boston. In Boston, increases in heavy precipitation events were associated with higher traffic injuries and property damage. As climate change-related heavy precipitation events are projected to increase in the USA, the associations found in this study should be of interest for road safety planning in a rapidly changing environment. CI - © 2021. The Author(s). FAU - Nazif-Munoz, José Ignacio AU - Nazif-Munoz JI AUID- ORCID: 0000-0002-8944-5182 AD - Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 150, place Charles-Le Moyne, Longueuil, QC, J4K 0A8, Canada. Jose.ignacio.nazif-munoz@usherbrooke.ca. AD - Centre de recherche Charles-Le Moyne - Saguenay - Lac-Saint-Jean, 150, place Charles‑Le Moyne, C. P. 200, Longueuil, Canadá. Jose.ignacio.nazif-munoz@usherbrooke.ca. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, 4th Floor West, 404N, Boston, MA, 02215, USA. Jose.ignacio.nazif-munoz@usherbrooke.ca. FAU - Martínez, Pablo AU - Martínez P AD - Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 150, place Charles-Le Moyne, Longueuil, QC, J4K 0A8, Canada. AD - Centre de recherche Charles-Le Moyne - Saguenay - Lac-Saint-Jean, 150, place Charles‑Le Moyne, C. P. 200, Longueuil, Canadá. FAU - Williams, Augusta AU - Williams A AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, 4th Floor West, 404N, Boston, MA, 02215, USA. FAU - Spengler, John AU - Spengler J AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 401 Park Drive, 4th Floor West, 404N, Boston, MA, 02215, USA. LA - eng PT - Journal Article DEP - 20210719 PL - England TA - Inj Epidemiol JT - Injury epidemiology JID - 101652639 PMC - PMC8287725 OTO - NOTNLM OT - Boston and Santo Domingo OT - Extreme weather conditions OT - Road safety OT - Time-series COIS- None. EDAT- 2021/07/21 06:00 MHDA- 2021/07/21 06:01 PMCR- 2021/07/19 CRDT- 2021/07/20 05:39 PHST- 2021/03/31 00:00 [received] PHST- 2021/06/27 00:00 [accepted] PHST- 2021/07/20 05:39 [entrez] PHST- 2021/07/21 06:00 [pubmed] PHST- 2021/07/21 06:01 [medline] PHST- 2021/07/19 00:00 [pmc-release] AID - 10.1186/s40621-021-00342-w [pii] AID - 342 [pii] AID - 10.1186/s40621-021-00342-w [doi] PST - epublish SO - Inj Epidemiol. 2021 Jul 19;8(1):47. doi: 10.1186/s40621-021-00342-w. PMID- 36232072 OWN - NLM STAT- MEDLINE DCOM- 20221017 LR - 20230114 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 19 IP - 19 DP - 2022 Oct 6 TI - The Slope Safety, Heavy Metal Leaching, and Pollutant Diffusion Prediction Properties under the Influence of Unclassified Cemented Paste Backfill in an Open Pit. LID - 10.3390/ijerph191912772 [doi] LID - 12772 AB - Open-pit unclassified cemented paste backfilling (OPUCPB) methods have not only addressed the disposal problems of tailings but also eliminated geological hazards of high and steep open pit slopes and created conditions for ecological restoration of the open pit in the future. In this paper, slope safety simulations, heavy metal leaching, groundwater monitoring, and pollutant diffusion predictions were examined to evaluate the slope safety pattern and environmental protection enabled by OPUCPB. The results showed that: (1) The safety factor of the open pit slope was proportional to the height of OPUCPB operation. Under the condition of seismic force and seepage field, the safety factor of slope B was increased from 1.188 to 1.574 by OPUCPB. (2) The toxic and harmful components in tailings were significantly stabilized by the OPUCPB. Under the conditions of acid leaching and water leaching, the quality of the leaching solution met the requirements of the class III limit of groundwater (GB/T14848-2017). (3) The monitoring results of groundwater quality around the open pit showed that the OPUCPB had no effect on groundwater, and the water quality met the requirements of the class III limit of groundwater (GB/T14848-2017). (4) Considering the diffusion prediction of pollutants and groundwater under extreme conditions, it was found that the pollution process is slow, and the shortest time required for pollutants to reach the standard limit is 232 d at a distance of 50 m from the leakage point. Therefore, the influence of OPUCPB can be controlled, and this method can achieve improved reclamation of open pits and safety treatment of tailings. It was worth popularizing and applying in mining enterprises. FAU - Chen, Ke AU - Chen K AD - School of Resources and Safety Engineering, Central South University, Changsha 410083, China. FAU - Zhang, Qinli AU - Zhang Q AD - School of Resources and Safety Engineering, Central South University, Changsha 410083, China. FAU - Tao, Yunbo AU - Tao Y AD - School of Resources and Safety Engineering, Central South University, Changsha 410083, China. FAU - Luo, Kai AU - Luo K AD - School of Resources and Safety Engineering, Central South University, Changsha 410083, China. FAU - Chen, Qiusong AU - Chen Q AUID- ORCID: 0000-0002-7588-8097 AD - School of Resources and Safety Engineering, Central South University, Changsha 410083, China. LA - eng PT - Journal Article DEP - 20221006 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 RN - 0 (Environmental Pollutants) RN - 0 (Metals, Heavy) SB - IM MH - *Environmental Pollutants MH - *Groundwater MH - *Metals, Heavy/analysis MH - Mining MH - Water Quality PMC - PMC9566217 OTO - NOTNLM OT - groundwater monitoring OT - heavy metal leaching OT - open pit OT - slope safety simulation OT - unclassified cemented paste backfill COIS- The authors declare no conflict of interest. EDAT- 2022/10/15 06:00 MHDA- 2022/10/18 06:00 PMCR- 2022/10/06 CRDT- 2022/10/14 02:03 PHST- 2022/09/04 00:00 [received] PHST- 2022/09/25 00:00 [revised] PHST- 2022/09/27 00:00 [accepted] PHST- 2022/10/14 02:03 [entrez] PHST- 2022/10/15 06:00 [pubmed] PHST- 2022/10/18 06:00 [medline] PHST- 2022/10/06 00:00 [pmc-release] AID - ijerph191912772 [pii] AID - ijerph-19-12772 [pii] AID - 10.3390/ijerph191912772 [doi] PST - epublish SO - Int J Environ Res Public Health. 2022 Oct 6;19(19):12772. doi: 10.3390/ijerph191912772. PMID- 21249854 STAT- Publisher PB - Agency for Healthcare Research and Quality CTI - Advances in Patient Safety DP - 2008 Aug TI - Home Health Care Patients and Safety Hazards in the Home: Preliminary Findings. BTI - Advances in Patient Safety: New Directions and Alternative Approaches (Vol. 1: Assessment) AB - Introduction: Home health care is the fastest growing sector in the health care industry, with an anticipated growth of 66 percent over the next 10 years and with over 7 million patients served each year. With the increasing acuteness of care provided in home health care and the increasing number of frail elderly that make up this patient population, it is important to identify risk factors that affect patient health and safety in this setting. Methods: A convenience sample of 1,561 home health aides, attendants, and personal care workers completed a risk assessment survey. Items addressed personal, patient, and home characteristics and health hazards. All activities had prior Institutional Review Board approval. Preliminary Results: Ninety-five percent of home health care workers (HHCWs) were female with an average of 8 years experience. The majority of clients were elderly, with a smaller percentage of adult (26 percent) and pediatric (7 percent) cases. HHCWs reported the following exposures at their clients’ homes: cockroaches (33 percent), cigarette smoke (30 percent), vermin (23 percent), irritating chemicals (17 percent), and peeling paint (15 percent). The following conditions were also described: clutter (17 percent), temperature extremes (9 percent), unsanitary (12 percent) and unsafe (6 percent) conditions in the home, neighborhood violence/crime (11 percent), and aggressive pets (6 percent). Two percent of respondents reported the presence of guns in the home. Additionally, 12 percent of HHCWs reported signs of abuse of their clients. Conclusion: Both HHCWs and home care patients appear to be at potential risk due to a variety of health hazards/exposures in the clients’ homes. Given the growing population of both HHCWs and recipients, it is important to document this risk as an important first step in prevention and management. FED - Henriksen, Kerm ED - Henriksen K FED - Battles, James B ED - Battles JB FED - Keyes, Margaret A ED - Keyes MA FED - Grady, Mary L ED - Grady ML FAU - Gershon, Robyn RM AU - Gershon RRM AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Pogorzelska, Monika AU - Pogorzelska M AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Qureshi, Kristine A AU - Qureshi KA AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Stone, Patricia W AU - Stone PW AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Canton, Allison N AU - Canton AN AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Samar, Stephanie M AU - Samar SM AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Westra, Leah J AU - Westra LJ AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Damsky, Marc R AU - Damsky MR AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) FAU - Sherman, Martin AU - Sherman M AD - Mailman School of Public Health, Columbia University, New York, NY (Dr. Gershon, Ms. Pogorzelska, Ms. Canton, Ms. Westra); School of Nursing, University of Hawaii, Honolulu, HI (Ms. Qureshi); School of Nursing, Columbia University, New York, NY (Dr. Stone); Department of Psychology, New York University, New York, NY (Ms. Samar); Mobile Health Management Services, Inc, New York, NY (Mr. Damsky); Department of Psychology, Loyola College, Baltimore, MD (Dr. Sherman) LA - eng PT - Review PT - Book Chapter PL - Rockville (MD) EDAT- 2008/08/01 00:00 CRDT- 2008/08/01 00:00 AID - NBK43619 [bookaccession] PMID- 30416054 OWN - NLM STAT- MEDLINE DCOM- 20190320 LR - 20221207 IS - 2212-5353 (Electronic) IS - 2212-5345 (Linking) VI - 57 IP - 1 DP - 2019 Jan TI - Safety and pharmacokinetics of Alpha-1 MP (Prolastin(®)-C) in Japanese patients with alpha(1)-antitrypsin (AAT) deficiency. PG - 89-96 LID - S2212-5345(18)30109-6 [pii] LID - 10.1016/j.resinv.2018.09.006 [doi] AB - BACKGROUND: Alpha(1)-Proteinase Inhibitor, Modified Process (Alpha-1 MP) is used for augmentation therapy in alpha1-antitrypsin deficiency (AATD), an extremely rare disease in Japan. Weekly doses of 60 mg/kg Alpha-1 MP have been shown to be safe and well tolerated in non-Japanese subjects, but the safety and pharmacokinetics (PK) have not been evaluated in Japanese subjects. The objectives of this study were to evaluate the safety and PK of 60 mg/kg Alpha-1 MP administered by weekly IV infusions over 8 weeks in Japanese subjects with AATD. METHODS: This was a multicenter, open-label trial in Japanese adults aged ≥20 years with AATD. Samples for evaluation of serum alpha(1)-PI concentration and PK parameters were collected at 10 time points until the seventh day after the last dose at Week 8: immediately before dosing, immediately after dosing (time 0), and 0.25, 2, 4, 8, 24, 48, 120, and 168 hours after dosing. RESULTS: Four subjects were analyzed. The median t(max) was 0.534 h. Mean ± SD values for t(½), C(max), and AUC(0-7days) were 150.4 ± 36.18 h, 174.2 ± 30.51 mg/dL, and 14,913.2 ± 1633.45 mg*h/dL, respectively. Mean trough concentration at week 8 was 55.4 ± 7.23 mg/dL. Alpha-1 MP therapy was safe, with no serious adverse events or deaths reported. Two treatment-emergent adverse events of fatigue in one subject were considered to be possibly related. CONCLUSIONS: The PK and safety of Alpha-1 MP in Japanese subjects with AATD were consistent with the Alpha-1 MP profile in non-Japanese subjects (ClinicalTrials.gov: NCT02870309; JAPIC CTI: JapicCTI-163160). CI - Copyright © 2018 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved. FAU - Seyama, Kuniaki AU - Seyama K AD - Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. Electronic address: kseyama@juntendo.ac.jp. FAU - Nukiwa, Toshihiro AU - Nukiwa T AD - Professor Emeritus, Tohoku University, Sendai, Japan. FAU - Sato, Tadashi AU - Sato T AD - Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. FAU - Suzuki, Masaru AU - Suzuki M AD - Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. FAU - Konno, Satoshi AU - Konno S AD - Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. FAU - Takahashi, Kazuhisa AU - Takahashi K AD - Division of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan. FAU - Nishimura, Masaharu AU - Nishimura M AD - Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. FAU - Steinmann, Kimberly AU - Steinmann K AD - Grifols Bioscience Research Group, Research Triangle Park, NC, USA. FAU - Sorrells, Susan AU - Sorrells S AD - Grifols Bioscience Research Group, Research Triangle Park, NC, USA. FAU - Chen, Junliang AU - Chen J AD - Grifols Bioscience Research Group, Research Triangle Park, NC, USA. FAU - Hayashi, Ken-Ichi AU - Hayashi KI AD - Grifols Japan KK, Osaka, Japan. LA - eng SI - ClinicalTrials.gov/NCT02870309 PT - Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20181108 PL - Netherlands TA - Respir Investig JT - Respiratory investigation JID - 101581124 RN - 0 (Serine Proteinase Inhibitors) RN - 0 (alpha 1-Antitrypsin) SB - IM MH - Aged MH - Asian People MH - Female MH - Humans MH - Infusions, Intravenous MH - Male MH - Middle Aged MH - Safety MH - Serine Proteinase Inhibitors/*administration & dosage/*pharmacokinetics MH - Time Factors MH - alpha 1-Antitrypsin/*administration & dosage/*pharmacokinetics MH - alpha 1-Antitrypsin Deficiency/*drug therapy/metabolism OTO - NOTNLM OT - AAT deficiency OT - Alpha(1)-proteinase inhibitor OT - Japanese OT - Pharmacokinetics OT - Safety EDAT- 2018/11/13 06:00 MHDA- 2019/03/21 06:00 CRDT- 2018/11/13 06:00 PHST- 2018/06/08 00:00 [received] PHST- 2018/09/13 00:00 [revised] PHST- 2018/09/27 00:00 [accepted] PHST- 2018/11/13 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2018/11/13 06:00 [entrez] AID - S2212-5345(18)30109-6 [pii] AID - 10.1016/j.resinv.2018.09.006 [doi] PST - ppublish SO - Respir Investig. 2019 Jan;57(1):89-96. doi: 10.1016/j.resinv.2018.09.006. Epub 2018 Nov 8. PMID- 30270909 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240329 IS - 2414-6366 (Electronic) IS - 2414-6366 (Linking) VI - 2 IP - 4 DP - 2017 Oct 4 TI - The Imperative of Palliation in the Management of Rabies Encephalomyelitis. LID - 10.3390/tropicalmed2040052 [doi] LID - 52 AB - The aim of this review is to guide clinicians in the practical management of patients suffering from rabies encephalomyelitis. This condition is eminently preventable by modern post-exposure vaccination, but is virtually always fatal in unvaccinated people. In the absence of any proven effective antiviral or other treatment, palliative care is an imperative to minimise suffering. Suspicion of rabies encephalomyelitis depends on recognising the classic symptomatology and eliciting a history of exposure to a possibly rabid mammal. Potentially treatable differential diagnoses must be eliminated, notably other infective encephalopathies. Laboratory confirmation of suspected rabies is not usually possible in many endemic areas, but is essential for public health surveillance. In a disease as agonising and terrifying as rabies encephalomyelitis, alleviation of distressing symptoms is the primary concern and overriding responsibility of medical staff. Calm, quiet conditions should be created, allowing relatives to communicate with the dying patient in safety and privacy. Palliative management must address thirst and dehydration, fever, anxiety, fear, restlessness, agitation, seizures, hypersecretion, and pain. As the infection progresses, coma and respiratory, cardiovascular, neurological, endocrine, or gastrointestinal complications will eventually ensue. When the facilities exist, the possibility of intensive care may arise, but although some patients may survive, they will be left with severe neurological sequelae. Recovery from rabies is extremely rare, and heroic measures with intensive care should be considered only in patients who have been previously vaccinated, develop rabies antibody within the first week of illness, or were infected by an American bat rabies virus. However, in most cases, clinicians must have the courage to offer compassionate palliation whenever the diagnosis of rabies encephalomyelitis is inescapable. FAU - Warrell, Mary AU - Warrell M AD - Oxford Vaccine Group, University of Oxford, Centre for Clinical Vaccinology & Tropical Medicine, Churchill Hospital, Old Rd, Headington, Oxford, OX3 7LJ, UK. mary.warrell@ndm.ox.ac.uk. FAU - Warrell, David A AU - Warrell DA AD - Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DW, UK. david.warrell@ndm.ox.ac.uk. FAU - Tarantola, Arnaud AU - Tarantola A AD - Institut Pasteur de Nouvelle-Calédonie, BP 61 ⁻ 98845 Nouméa cedex, New Caledonia. atarantola@pasteur.nc. LA - eng PT - Journal Article PT - Review DEP - 20171004 PL - Switzerland TA - Trop Med Infect Dis JT - Tropical medicine and infectious disease JID - 101709042 PMC - PMC6082067 OTO - NOTNLM OT - diagnosis OT - encephalomyelitis OT - palliation OT - rabies OT - treatment COIS- The authors declare no conflict of interest. EDAT- 2018/10/03 06:00 MHDA- 2018/10/03 06:01 PMCR- 2017/10/04 CRDT- 2018/10/02 06:00 PHST- 2017/09/08 00:00 [received] PHST- 2017/09/18 00:00 [revised] PHST- 2017/09/28 00:00 [accepted] PHST- 2018/10/02 06:00 [entrez] PHST- 2018/10/03 06:00 [pubmed] PHST- 2018/10/03 06:01 [medline] PHST- 2017/10/04 00:00 [pmc-release] AID - tropicalmed2040052 [pii] AID - tropicalmed-02-00052 [pii] AID - 10.3390/tropicalmed2040052 [doi] PST - epublish SO - Trop Med Infect Dis. 2017 Oct 4;2(4):52. doi: 10.3390/tropicalmed2040052. PMID- 38976593 OWN - NLM STAT- MEDLINE DCOM- 20241030 LR - 20241030 IS - 2191-0286 (Electronic) IS - 0792-6855 (Linking) VI - 35 IP - 4-5 DP - 2024 Jul 1 TI - Deucravacitinib: moderate-to-severe plaque psoriasis preventable? PG - 225-230 LID - 10.1515/jbcpp-2023-0174 [doi] AB - Psoriasis is a persistent, inflammatory, and autoimmune condition that is difficult to treat. Estimates of the prevalence of psoriasis in people range from 0.27 % (95 % confidence interval 0.17 to 0.36) to 11.4 %, depending on factors such as age, sex, geography, ethnicity, genetics, and environmental factors. While systemic treatments are typically required for patients with moderate-to-severe instances of psoriasis, topical therapies are frequently effective for treating minor forms. In fact, phototherapy is frequently constrained by logistical considerations, and conventional systemic therapies are frequently avoided due to contraindications or the danger of adverse outcomes. In order to better serve the patient and achieve a greater level of quality of life, especially in order to sustain long-term efficacy, there is still a need for innovative therapies, which are always welcomed. Deucravacitinib is a first-in-class oral tyrosine kinase 2 (TYK2) inhibitor that is extremely selective. Through an allosteric mechanism, it stabilises an inhibitory connection between the regulatory and catalytic domains of TYK2's pseudokinase regulatory domain, which is catalytically inactive. This can be used to treat a variety of immune-mediated conditions, such as inflammatory bowel disease, lupus, psoriatic arthritis, and psoriasis. US-FDA has approved this drug on 9 September 2022 for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. This article aims to review the current knowledge on the efficacy and safety of deucravacitinib for the management of psoriasis. CI - © 2024 Walter de Gruyter GmbH, Berlin/Boston. FAU - Kaur, Manmeet AU - Kaur M AD - Department of Pharmacology, Kalpana Chawla Government Medical College, Karnal, Haryana, India. FAU - Misra, Saurav AU - Misra S AD - Department of Pharmacology, Kalpana Chawla Government Medical College, Karnal, Haryana, India. LA - eng PT - Journal Article PT - Review DEP - 20240709 PL - Germany TA - J Basic Clin Physiol Pharmacol JT - Journal of basic and clinical physiology and pharmacology JID - 9101750 RN - 0 (Protein Kinase Inhibitors) SB - IM MH - Humans MH - *Psoriasis/drug therapy MH - Severity of Illness Index MH - Protein Kinase Inhibitors/therapeutic use MH - Animals MH - Quality of Life OTO - NOTNLM OT - deucravacitinib OT - psoriasis OT - tyrosine kinase 2 (TYK2) inhibitor EDAT- 2024/07/08 18:42 MHDA- 2024/10/30 06:21 CRDT- 2024/07/08 14:02 PHST- 2023/07/17 00:00 [received] PHST- 2024/06/25 00:00 [accepted] PHST- 2024/10/30 06:21 [medline] PHST- 2024/07/08 18:42 [pubmed] PHST- 2024/07/08 14:02 [entrez] AID - jbcpp-2023-0174 [pii] AID - 10.1515/jbcpp-2023-0174 [doi] PST - epublish SO - J Basic Clin Physiol Pharmacol. 2024 Jul 9;35(4-5):225-230. doi: 10.1515/jbcpp-2023-0174. eCollection 2024 Jul 1. PMID- 31188022 OWN - NLM STAT- MEDLINE DCOM- 20200717 LR - 20200717 IS - 1556-7125 (Electronic) IS - 1535-3141 (Print) IS - 1535-3141 (Linking) VI - 16 IP - 7 DP - 2019 Jul TI - Investing in Food Safety for Developing Countries: Opportunities and Challenges in Applying Whole-Genome Sequencing for Food Safety Management. PG - 463-473 LID - 10.1089/fpd.2018.2599 [doi] AB - Whole-genome sequencing (WGS) has become a significant tool in investigating foodborne disease outbreaks and some countries have incorporated WGS into national food control systems. However, WGS poses technical challenges that deter developing countries from incorporating it into their food safety management system. A rapid scoping review was conducted, followed by a focus group session, to understand the current situation regarding the use of WGS for foodborne disease surveillance and food monitoring at the global level and identify key limiting factors for developing countries in adopting WGS for their food control systems. The results showed that some developed nations routinely use WGS in their food surveillance systems resulting in more precise understanding of the causes of outbreaks. In developing nations, knowledge of WGS exists in the academic/research sectors; however, there is limited understanding at the government level regarding the usefulness of WGS for food safety regulatory activities. Thus, incorporation of WGS is extremely limited in most developing nations. While some countries lack the capacity to collect and analyze the data generated from WGS, the most significant technical gap in most developing countries is in data interpretation using bioinformatics. The gaps in knowledge and capacities between developed and developing nations regarding use of WGS likely introduce an inequality in international food trade, and thus, relevant international organizations, as well as the countries that are already proficient in the use of WGS, have significant roles in assisting developing nations to be able to fully benefit from the technology and its applications in food safety management. FAU - Apruzzese, Isabella AU - Apruzzese I AD - 1 Franco Prattico Masters' Course in Science Communication, Trieste, Italy. FAU - Song, Eunyeong AU - Song E AD - 2 Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Fujian, China. FAU - Bonah, Ernest AU - Bonah E AD - 3 Food and Drugs Authority, Northern Regional Office, Accra, Ghana. FAU - Sanidad, Vernadette S AU - Sanidad VS AD - 4 National Meat Inspection Service, Manila, Philippines. FAU - Leekitcharoenphon, Pimlapas AU - Leekitcharoenphon P AD - 5 National Food Institute, Technical University of Denmark, Copenhagen, Denmark. FAU - Medardus, Julius John AU - Medardus JJ AD - 6 Department of Veterinary Anatomy and Pathology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania. FAU - Abdalla, Nagmeldin AU - Abdalla N AD - 7 Sudanese Standard and Metrology Organization, Khartoum, Sudan. FAU - Hosseini, Hedayat AU - Hosseini H AD - 8 National Nutrition & Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Teheran, Iran. FAU - Takeuchi, Masami AU - Takeuchi M AD - 9 Food and Agriculture Organization of the United Nations, Rome, Italy. LA - eng PT - Journal Article PT - Review DEP - 20190612 PL - United States TA - Foodborne Pathog Dis JT - Foodborne pathogens and disease JID - 101120121 SB - IM MH - *Developing Countries MH - Disease Outbreaks/*prevention & control MH - *Food Safety MH - Foodborne Diseases/microbiology/*prevention & control MH - Genome, Bacterial/genetics MH - Humans MH - Safety Management MH - *Whole Genome Sequencing PMC - PMC6653794 OTO - NOTNLM OT - Food and Agriculture Organization of the United Nations OT - developing countries OT - food safety OT - foodborne disease surveillance OT - next-generation sequencing OT - whole-genome sequencing COIS- No competing financial interests exist. EDAT- 2019/06/13 06:00 MHDA- 2020/07/18 06:00 PMCR- 2019/07/09 CRDT- 2019/06/13 06:00 PHST- 2019/06/13 06:00 [pubmed] PHST- 2020/07/18 06:00 [medline] PHST- 2019/06/13 06:00 [entrez] PHST- 2019/07/09 00:00 [pmc-release] AID - 10.1089/fpd.2018.2599 [pii] AID - 10.1089/fpd.2018.2599 [doi] PST - ppublish SO - Foodborne Pathog Dis. 2019 Jul;16(7):463-473. doi: 10.1089/fpd.2018.2599. Epub 2019 Jun 12. PMID- 38050161 OWN - NLM STAT- MEDLINE DCOM- 20240816 LR - 20240829 IS - 2044-5423 (Electronic) IS - 2044-5415 (Print) IS - 2044-5415 (Linking) VI - 33 IP - 9 DP - 2024 Aug 16 TI - Patient safety in remote primary care encounters: multimethod qualitative study combining Safety I and Safety II analysis. PG - 573-586 LID - 10.1136/bmjqs-2023-016674 [doi] AB - BACKGROUND: Triage and clinical consultations increasingly occur remotely. We aimed to learn why safety incidents occur in remote encounters and how to prevent them. SETTING AND SAMPLE: UK primary care. 95 safety incidents (complaints, settled indemnity claims and reports) involving remote interactions. Separately, 12 general practices followed 2021-2023. METHODS: Multimethod qualitative study. We explored causes of real safety incidents retrospectively ('Safety I' analysis). In a prospective longitudinal study, we used interviews and ethnographic observation to produce individual, organisational and system-level explanations for why safety and near-miss incidents (rarely) occurred and why they did not occur more often ('Safety II' analysis). Data were analysed thematically. An interpretive synthesis of why safety incidents occur, and why they do not occur more often, was refined following member checking with safety experts and lived experience experts. RESULTS: Safety incidents were characterised by inappropriate modality, poor rapport building, inadequate information gathering, limited clinical assessment, inappropriate pathway (eg, wrong algorithm) and inadequate attention to social circumstances. These resulted in missed, inaccurate or delayed diagnoses, underestimation of severity or urgency, delayed referral, incorrect or delayed treatment, poor safety netting and inadequate follow-up. Patients with complex pre-existing conditions, cardiac or abdominal emergencies, vague or generalised symptoms, safeguarding issues, failure to respond to previous treatment or difficulty communicating seemed especially vulnerable. General practices were facing resource constraints, understaffing and high demand. Triage and care pathways were complex, hard to navigate and involved multiple staff. In this context, patient safety often depended on individual staff taking initiative, speaking up or personalising solutions. CONCLUSION: While safety incidents are extremely rare in remote primary care, deaths and serious harms have resulted. We offer suggestions for patient, staff and system-level mitigations. CI - © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. FAU - Payne, Rebecca AU - Payne R AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Clarke, Aileen AU - Clarke A AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Swann, Nadia AU - Swann N AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - van Dael, Jackie AU - van Dael J AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Brenman, Natassia AU - Brenman N AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Rosen, Rebecca AU - Rosen R AD - Nuffield Trust, London, UK. FAU - Mackridge, Adam AU - Mackridge A AD - Betsi Cadwaladr University Health Board, Bangor, UK. FAU - Moore, Lucy AU - Moore L AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Kalin, Asli AU - Kalin A AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Ladds, Emma AU - Ladds E AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Hemmings, Nina AU - Hemmings N AD - Nuffield Trust, London, UK. FAU - Rybczynska-Bunt, Sarah AU - Rybczynska-Bunt S AD - Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK. FAU - Faulkner, Stuart AU - Faulkner S AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Hanson, Isabel AU - Hanson I AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Spitters, Sophie AU - Spitters S AD - Wolfson Institute of Population Health, Queen Mary University of London, London, UK. FAU - Wieringa, Sietse AU - Wieringa S AUID- ORCID: 0000-0002-7758-8493 AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. AD - Sustainable Health Unit, University of Oslo, Oslo, Norway. FAU - Dakin, Francesca H AU - Dakin FH AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Shaw, Sara E AU - Shaw SE AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Wherton, Joseph AU - Wherton J AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Byng, Richard AU - Byng R AD - Peninsula Schools of Medicine and Dentistry, University of Plymouth, Plymouth, UK. FAU - Husain, Laiba AU - Husain L AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Greenhalgh, Trisha AU - Greenhalgh T AUID- ORCID: 0000-0003-2369-8088 AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK trish.greenhalgh@phc.ox.ac.uk. LA - eng PT - Journal Article DEP - 20240816 PL - England TA - BMJ Qual Saf JT - BMJ quality & safety JID - 101546984 SB - IM CIN - doi: 10.1136/bmjqs-2023-016872 MH - Humans MH - *Patient Safety MH - *Primary Health Care MH - *Qualitative Research MH - United Kingdom MH - Longitudinal Studies MH - *Triage MH - Prospective Studies MH - Female MH - Male MH - Retrospective Studies PMC - PMC11347200 OTO - NOTNLM OT - Diagnostic errors OT - Prehospital care OT - Primary care OT - Qualitative research OT - Safety culture COIS- Competing interests: RP was National Professional Advisor, Care Quality Commission 2017–2022, where her role included investigation of safety issues. EDAT- 2023/12/05 12:41 MHDA- 2024/08/17 15:44 PMCR- 2024/08/27 CRDT- 2023/12/05 01:03 PHST- 2023/08/24 00:00 [received] PHST- 2023/10/31 00:00 [accepted] PHST- 2024/08/17 15:44 [medline] PHST- 2023/12/05 12:41 [pubmed] PHST- 2023/12/05 01:03 [entrez] PHST- 2024/08/27 00:00 [pmc-release] AID - bmjqs-2023-016674 [pii] AID - 10.1136/bmjqs-2023-016674 [doi] PST - epublish SO - BMJ Qual Saf. 2024 Aug 16;33(9):573-586. doi: 10.1136/bmjqs-2023-016674. PMID- 37821253 OWN - NLM STAT- MEDLINE DCOM- 20231216 LR - 20231216 IS - 0151-9638 (Print) IS - 0151-9638 (Linking) VI - 150 IP - 4 DP - 2023 Dec TI - A survey of patients with facial angiofibromas associated with tuberous sclerosis complex: Short-, medium- and long-term efficacy and safety of topical rapamycin. PG - 270-273 LID - S0151-9638(23)00071-6 [pii] LID - 10.1016/j.annder.2023.06.009 [doi] AB - AIMS: Topical rapamycin is used to reduce facial angiofibromas in patients with tuberous sclerosis (TSC). In the absence of a commercially available preparation, numerous formulations have been tested clinically, although only in the short term. METHODS: The pharmacy at Angers University Hospital (France) produced a cream formulation that was administered to people presenting this genetic disease. We conducted a questionnaire-based survey among 79 patients with TSC about their perceptions regarding the short-, medium- and long-term efficacy and safety of a topical rapamycin preparation in relation to facial angiofibromas. RESULTS: This formulation was very well tolerated and its efficacy was sustained over the long term with a mean treatment duration of 33 months (extremes 1-60). Efficacy was rated ≥ 8/10 by 67.1% of patients while safety was rated ≥ 8/10 by 84.8% of patients. CONCLUSION: This survey supports the safety and efficacy of topical rapamycin in the short-, medium- and long-term in the treatment of facial angiofibromas in a cohort of 79 patients with TSC. CI - Copyright © 2023 Elsevier Masson SAS. All rights reserved. FAU - Sigg, N AU - Sigg N AD - Dermatology Department, CRMR MAGEC Nord, Angers University Hospital, France. Electronic address: nina.sigg@chu-angers.fr. FAU - Fouquet, J AU - Fouquet J AD - Dermatology Department, CRMR MAGEC Nord, Angers University Hospital, France. FAU - Morin, D AU - Morin D AD - Dermatology Department, CRMR MAGEC Nord, Angers University Hospital, France. FAU - Farges, D AU - Farges D AD - Dermatology Department, CRMR MAGEC Nord, Angers University Hospital, France. FAU - Vrignaud, S AU - Vrignaud S AD - Pharmacy, Angers University Hospital, France. FAU - Martin, L AU - Martin L AD - Dermatology Department, CRMR MAGEC Nord, Angers University Hospital, France. LA - eng PT - Journal Article DEP - 20231009 PL - France TA - Ann Dermatol Venereol JT - Annales de dermatologie et de venereologie JID - 7702013 RN - 0 (Immunosuppressive Agents) RN - W36ZG6FT64 (Sirolimus) SB - IM MH - Humans MH - *Tuberous Sclerosis/complications MH - *Angiofibroma/drug therapy/complications MH - *Facial Neoplasms/drug therapy/etiology MH - Immunosuppressive Agents/therapeutic use MH - Sirolimus/adverse effects OTO - NOTNLM OT - Angiofibromas OT - Drug survival OT - Rapamycin OT - Tuberous sclerosis complex COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/12 00:43 MHDA- 2023/12/17 09:43 CRDT- 2023/10/11 21:59 PHST- 2021/09/30 00:00 [received] PHST- 2023/04/14 00:00 [revised] PHST- 2023/06/22 00:00 [accepted] PHST- 2023/12/17 09:43 [medline] PHST- 2023/10/12 00:43 [pubmed] PHST- 2023/10/11 21:59 [entrez] AID - S0151-9638(23)00071-6 [pii] AID - 10.1016/j.annder.2023.06.009 [doi] PST - ppublish SO - Ann Dermatol Venereol. 2023 Dec;150(4):270-273. doi: 10.1016/j.annder.2023.06.009. Epub 2023 Oct 9. PMID- 32029360 OWN - NLM STAT- MEDLINE DCOM- 20210412 LR - 20210412 IS - 1879-307X (Electronic) IS - 1364-6613 (Linking) VI - 24 IP - 3 DP - 2020 Mar TI - Space, Time, and Fear: Survival Computations along Defensive Circuits. PG - 228-241 LID - S1364-6613(20)30002-4 [pii] LID - 10.1016/j.tics.2019.12.016 [doi] AB - Naturalistic observations show that decisions to avoid or escape predators occur at different spatiotemporal scales and that they are supported by different computations and neural circuits. At their extremes, proximal threats are addressed by a limited repertoire of reflexive and myopic actions, reflecting reduced decision and state spaces and model-free (MF) architectures. Conversely, distal threats allow increased information processing supported by model-based (MB) operations, including affective prospection, replay, and planning. However, MF and MB computations are often intertwined, and under conditions of safety the foundations for future effective reactive execution can be laid through MB instruction of MF control. Together, these computations are associated with distinct population codes embedded within a distributed defensive circuitry whose goal is to determine and realize the best policy. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Mobbs, Dean AU - Mobbs D AD - Department of Humanities and Social Sciences and Computation, California Institute of Technology, 1200 E. California Blvd, HSS 228-77, Pasadena, CA 91125, USA; Neural Systems Program at the California Institute of Technology, 1200 E. California Blvd, HSS 228-77, Pasadena, CA 91125, USA. Electronic address: dmobbs@caltech.edu. FAU - Headley, Drew B AU - Headley DB AD - Center for Molecular and Behavioral Neuroscience, Rutgers University - Newark, 197 University Avenue, Newark, NJ 07102, USA. FAU - Ding, Weilun AU - Ding W AD - Department of Humanities and Social Sciences and Computation, California Institute of Technology, 1200 E. California Blvd, HSS 228-77, Pasadena, CA 91125, USA. FAU - Dayan, Peter AU - Dayan P AD - Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany; The University of Tübingen, Tübingen, Germany. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20200203 PL - England TA - Trends Cogn Sci JT - Trends in cognitive sciences JID - 9708669 SB - IM MH - Decision Making MH - *Fear MH - Humans OTO - NOTNLM OT - Dyna OT - anxiety OT - fear OT - hippocampus OT - model based OT - model free OT - periaqueductal gray OT - prefrontal cortex OT - threat imminence continuum EDAT- 2020/02/08 06:00 MHDA- 2021/04/13 06:00 CRDT- 2020/02/08 06:00 PHST- 2019/11/01 00:00 [received] PHST- 2019/12/24 00:00 [revised] PHST- 2019/12/29 00:00 [accepted] PHST- 2020/02/08 06:00 [pubmed] PHST- 2021/04/13 06:00 [medline] PHST- 2020/02/08 06:00 [entrez] AID - S1364-6613(20)30002-4 [pii] AID - 10.1016/j.tics.2019.12.016 [doi] PST - ppublish SO - Trends Cogn Sci. 2020 Mar;24(3):228-241. doi: 10.1016/j.tics.2019.12.016. Epub 2020 Feb 3. PMID- 38429663 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240304 IS - 1865-1372 (Print) IS - 1865-1380 (Electronic) IS - 1865-1372 (Linking) VI - 17 IP - 1 DP - 2024 Mar 1 TI - The leading role of expert safety knowledge in supporting the mission of caring for patients during man-made and natural disasters: state of emergency medicine in Ethiopia, Myanmar, and Ukraine. PG - 31 LID - 10.1186/s12245-024-00609-1 [doi] LID - 31 AB - Preparedness to endure extreme situations such as natural disasters or military conflicts is not commonplace in healthcare training programs. Moreover, multidisciplinary teams in health services rarely (if ever) include experts in security. However, when emergency situations occur, prevailing healthcare demands do not cease to exist, and unexpected demands often surge due to the shortage of other services and supplies or as a consequence of the emergency condition itself.With services in 45 countries, AIDS Healthcare Foundation (AHF) has operated in several conflict zones, facing broad and challenging security demands. Since 2017 AHF has implemented the Global Department of Safety and Security (GDSS), a dedicated intelligence and safety program that had a key role in the security monitoring, preparedness, and defense responses, assisting staff members and clients during recent conflicts.In this manuscript, we describe the experience of AHF's GDSS in three recent military conflicts in Ethiopia, Myanmar, and Ukraine, and provide insights into steps that can be taken to assure staff safety and support the mission of caring for patients throughout catastrophic events. CI - © 2024. The Author(s). FAU - Miles, Ralph C AU - Miles RC AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. FAU - Avelino-Silva, Vivian I AU - Avelino-Silva VI AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. viviansilva87@gmail.com. FAU - Odoke, Wilfred AU - Odoke W AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. FAU - van den Hombergh, Jan AU - van den Hombergh J AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. FAU - Fonseca, Fernanda F AU - Fonseca FF AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. FAU - GebreMichael, Mengistu AU - GebreMichael M AD - Aids Healthcare Foundation Ethiopia, Addis Ababa, Ethiopia. FAU - Lopatina, Yaroslava AU - Lopatina Y AD - Aids Healthcare Foundation Ukraine, Kyiv, Ukraine. FAU - Oo, Win AU - Oo W AD - Aids Healthcare Foundation Myanmar, Yangon, Myanmar. FAU - Benzaken, Adele Schwartz AU - Benzaken AS AD - Aids Healthcare Foundation Global Program, 6255 Sunset Blvd., 21st Fl, Los Angeles, CA, 90028, USA. LA - eng PT - Journal Article DEP - 20240301 PL - England TA - Int J Emerg Med JT - International journal of emergency medicine JID - 101469435 PMC - PMC10905824 OTO - NOTNLM OT - Civil Defense OT - Disaster Planning OT - Health Care Facilities, Manpower, and services OT - Security measures COIS- The authors declare no competing interests. EDAT- 2024/03/02 10:42 MHDA- 2024/03/02 10:43 PMCR- 2024/03/01 CRDT- 2024/03/01 23:40 PHST- 2023/10/10 00:00 [received] PHST- 2024/02/22 00:00 [accepted] PHST- 2024/03/02 10:43 [medline] PHST- 2024/03/02 10:42 [pubmed] PHST- 2024/03/01 23:40 [entrez] PHST- 2024/03/01 00:00 [pmc-release] AID - 10.1186/s12245-024-00609-1 [pii] AID - 609 [pii] AID - 10.1186/s12245-024-00609-1 [doi] PST - epublish SO - Int J Emerg Med. 2024 Mar 1;17(1):31. doi: 10.1186/s12245-024-00609-1. PMID- 36638266 OWN - NLM STAT- MEDLINE DCOM- 20230117 LR - 20230203 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 35 IP - 1 DP - 2023 Jan TI - The impact of winter warming and more frequent icing events on reindeer herder occupational safety, health, and wellbeing. PG - e23790 LID - 10.1002/ajhb.23790 [doi] AB - BACKGROUND: Northern Finland, like the rest of the Arctic, has experienced increases in mean annual temperature, the number of winter rains, the number of thaw-freeze days, the number of extremely warm weather events, and a shortened snow season. These changes have produced numerous problems for reindeer herders whose livelihoods rely on a healthy ecosystem with predictable weather patterns. METHODS: We performed a scoping literature review to assess how climate change induced extreme weather has negatively impacted reindeer herding as well as the health and wellbeing of reindeer herders. RESULTS: Late snow cover negatively impacts reindeer herding through a more widely dispersed herd that increases the work to gather reindeer, leads to reduced calf weight, and results in less meat for sale. This increased labor, especially in extreme cold conditions, can also negatively impact reindeer herder health. Icing due to thaw-freeze and rain-on-snow events makes it impossible for reindeer to dig through the snow to access lichens, increasing the need for reindeer herders to keep the herd in winter enclosures and provide supplemental feed. CONCLUSION: Climate change induced weather events such as late snow cover and icing increase reindeer herder efforts and expenses, put their livelihood at risk, and put their health at risk. CI - © 2022 Wiley Periodicals LLC. FAU - Ocobock, Cara AU - Ocobock C AUID- ORCID: 0000-0002-6949-2029 AD - Department of Anthropology, University of Notre Dame, Notre Dame, Indiana, USA. AD - Eck Institute for Global Health, Institute for Educational Initiatives, University of Notre Dame, Notre Dame, Indiana, USA. FAU - Turunen, Minna AU - Turunen M AD - Arctic Centre, University of Lapland, Rovaniemi, Finland. FAU - Soppela, Päivi AU - Soppela P AD - Arctic Centre, University of Lapland, Rovaniemi, Finland. FAU - Rasmus, Sirpa AU - Rasmus S AD - Arctic Centre, University of Lapland, Rovaniemi, Finland. AD - Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220809 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Animals MH - Ecosystem MH - *Reindeer MH - Seasons MH - *Occupational Health MH - Rain EDAT- 2023/01/14 06:00 MHDA- 2023/01/18 06:00 CRDT- 2023/01/13 15:32 PHST- 2022/07/14 00:00 [revised] PHST- 2022/05/12 00:00 [received] PHST- 2022/07/19 00:00 [accepted] PHST- 2023/01/13 15:32 [entrez] PHST- 2023/01/14 06:00 [pubmed] PHST- 2023/01/18 06:00 [medline] AID - 10.1002/ajhb.23790 [doi] PST - ppublish SO - Am J Hum Biol. 2023 Jan;35(1):e23790. doi: 10.1002/ajhb.23790. Epub 2022 Aug 9. PMID- 35911625 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221108 IS - 1578-1291 (Electronic) IS - 1130-2399 (Print) IS - 1130-2399 (Linking) VI - 33 DP - 2022 Sep TI - [Hand hygiene and pandemic. Controversies]. PG - S40-S44 LID - 10.1016/j.enfi.2022.06.003 [doi] AB - During the COVID-19 pandemic, the world's healthcare systems were extremely strained. Intensive care units were stretched to capacity and healthcare facilities were forced to set up spaces to care for critically ill patients. Professionals were required to work in strenuous conditions, completely disrupting their work routines.In this scenario, hand hygiene and the use of gloves by healthcare professionals became a critical point of transmission risk.The results of the ENVIN study in 2020 and 2021, corresponding to the pandemic period, showed worrying data on the increase in infection rates, with rates rising by 250% at the worst moments of the pandemic. This suggested that excessive risk situations were occurring for the patient. Any preventive strategy must place correct hand hygiene and proper use of gloves among its priority objectives. For this reason, the Project Zero Advisory Board made a series of adaptations and recommendations based on available evidence and expert opinion related to hand hygiene and glove use during the pandemic situation to promote best practice in extreme situations. This article reviews the key aspects of hand hygiene as part of the WHO safety strategy, the main barriers to compliance and the main adaptations proposed by the Advisory Board of the Zero projects. CI - © 2022 Sociedad Española de Enfermería Intensiva y Unidades Coronarias (SEEIUC). Published by Elsevier España, S.L.U. All rights reserved. FAU - Fernández-Moreno, I AU - Fernández-Moreno I AD - Corporación Sanitaria Parc Taulí, Sabadell, Barcelona, España. FAU - García-Díez, R AU - García-Díez R AD - Área de Seguridad del Paciente, Osi Bilbao, Basurto, Bilbao, Vizcaya. FAU - Vázquez-Calatayud, M AU - Vázquez-Calatayud M AD - Área de Desarrollo Profesional e Investigación en Enfermería, Clínica Universidad de Navarra, Universidad de Navarra, Grupo de investigación ICCP-UNAV, Innovación para un Cuidado Centrado en la Persona, Instituto de Investigación Sanitaria de Navarra (IdisNA), Pamplona, Navarra, España. CN - Comité Asesor del Programa de Seguridad de los Proyectos Zero LA - spa PT - English Abstract PT - Journal Article PT - Review TT - Higiene de manos y pandemia. Controversias. DEP - 20220723 PL - Spain TA - Enferm Intensiva JT - Enfermeria intensiva JID - 9517771 PMC - PMC9308018 OTO - NOTNLM OT - Adaptations OT - COVID-19 OT - Care-associated infection OT - Gloves OT - Hand hygiene OT - Recommendations EDAT- 2022/08/02 06:00 MHDA- 2022/08/02 06:01 PMCR- 2022/07/23 CRDT- 2022/08/01 03:49 PHST- 2022/08/02 06:00 [pubmed] PHST- 2022/08/02 06:01 [medline] PHST- 2022/08/01 03:49 [entrez] PHST- 2022/07/23 00:00 [pmc-release] AID - S1130-2399(22)00074-8 [pii] AID - 10.1016/j.enfi.2022.06.003 [doi] PST - ppublish SO - Enferm Intensiva. 2022 Sep;33:S40-S44. doi: 10.1016/j.enfi.2022.06.003. Epub 2022 Jul 23. PMID- 33040991 OWN - NLM STAT- MEDLINE DCOM- 20210802 LR - 20210802 IS - 1557-9786 (Electronic) IS - 1064-9689 (Linking) VI - 28 IP - 4 DP - 2020 Nov TI - MR Imaging Safety Considerations of Gadolinium-Based Contrast Agents: Gadolinium Retention and Nephrogenic Systemic Fibrosis. PG - 497-507 LID - S1064-9689(20)30038-6 [pii] LID - 10.1016/j.mric.2020.06.001 [doi] AB - Gadolinium (Gd)-based contrast agents (GBCAs) have revolutionized of MR imaging, enabling physicians to obtain life-saving medical information that often cannot be obtained with unenhanced MR imaging or other imaging modalities. Since regulatory approval in 1988, more than 450 million intravenous GBCA doses have been administered worldwide, with an extremely favorable pharmacologic safety profile. Recent evidence has demonstrated, however, that a small fraction of Gd is retained in human tissues. No direct correlation between Gd retention and clinical effects has been confirmed; however, a subset of patients have attributed various symptoms to GBCA exposure. This review details current knowledge regarding GBCA safety. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - McDonald, Jennifer S AU - McDonald JS AD - Department of Radiology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address: mcdonald.jennifer@mayo.edu. FAU - McDonald, Robert J AU - McDonald RJ AD - Department of Radiology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Magn Reson Imaging Clin N Am JT - Magnetic resonance imaging clinics of North America JID - 9422762 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Contrast Media/*pharmacokinetics MH - Gadolinium/*pharmacokinetics MH - Humans MH - Magnetic Resonance Imaging/adverse effects/*methods MH - Nephrogenic Fibrosing Dermopathy/*diagnostic imaging MH - *Patient Safety MH - Practice Guidelines as Topic OTO - NOTNLM OT - Gadolinium deposition disease OT - Gadolinium retention OT - Gadolinium-based contrast agents OT - MR imaging contrast agent OT - Nephrogenic systemic fibrosis OT - Radiology safety COIS- Disclosure J.S. McDonald and R.J. McDonald report research grants with GE Healthcare. R.J. McDonald report research grants with Bracco Imaging. J.S. McDonald and R.J. McDonald serve as scientific advisors for GE Healthcare. EDAT- 2020/10/13 06:00 MHDA- 2021/08/03 06:00 CRDT- 2020/10/12 05:23 PHST- 2020/10/12 05:23 [entrez] PHST- 2020/10/13 06:00 [pubmed] PHST- 2021/08/03 06:00 [medline] AID - S1064-9689(20)30038-6 [pii] AID - 10.1016/j.mric.2020.06.001 [doi] PST - ppublish SO - Magn Reson Imaging Clin N Am. 2020 Nov;28(4):497-507. doi: 10.1016/j.mric.2020.06.001. PMID- 31668349 OWN - NLM STAT- MEDLINE DCOM- 20200210 LR - 20200210 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 134 DP - 2020 Jan TI - Road safety of passing maneuvers: A bivariate extreme value theory approach under non-stationary conditions. PG - 105315 LID - S0001-4575(19)31388-0 [pii] LID - 10.1016/j.aap.2019.105315 [doi] AB - Observed accidents have been the main resource for road safety analysis over the past decades. Although such reliance seems quite straightforward, the rare nature of these events has made safety difficult to assess, especially for new and innovative traffic treatments. Surrogate measures of safety have allowed to step away from traditional safety performance functions and analyze safety performance without relying on accident records. In recent years, the use of extreme value theory (EV) models in combination with surrogate safety measures to estimate accident probabilities has gained popularity within the safety community. In this paper we extend existing efforts on EV for accident probability estimation for two dependent surrogate measures. Using detailed trajectory data from a driving simulator, we model the joint probability of head-on and rear-end collisions in passing maneuvers. We apply the Block Maxima method and estimate several extremal univariate and bivariate models, including the logistic copula. In our estimation we account for driver specific characteristics and road infrastructure variables. We show that accounting for these factors improve the head-on and rear-end collision probabilities estimation. This work highlights the importance of considering driver and road heterogeneity in evaluating related safety events, of relevance to interventions both for in-vehicle and infrastructure-based solutions. Such features are essential to keep up with the expectations from surrogate safety measures for the integrated analysis of accident phenomena, which show to significantly improve from the best known stationary extreme value models. CI - Copyright © 2019 Elsevier Ltd. All rights reserved. FAU - Cavadas, Joana AU - Cavadas J AD - CITTA, Department of Civil Engineering, University of Coimbra, Rua Luís Reis Santos - Pólo II, 3030-788, Coimbra, Portugal. Electronic address: joana.cavadas@uc.pt. FAU - Azevedo, Carlos Lima AU - Azevedo CL AD - Department of Technology, Management and Economics, Technical University of Denmark, Anker Engelunds Vej 1, 2800 Kgs, Lyngby, Denmark. Electronic address: climaz@dtu.dk. FAU - Farah, Haneen AU - Farah H AD - Department Transport and Planning, Faculty of Civil Engineering and Geosciences, Delft University of Technology, Stevinweg 1, P.O. Box 5048, 2600 GA, Delft, the Netherlands. Electronic address: h.farah@tudelft.nl. FAU - Ferreira, Ana AU - Ferreira A AD - Department of Mathematics, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais 1, 1049-001, Lisbon, Portugal. Electronic address: anafh@tecnico.ulisboa.pt. LA - eng PT - Journal Article DEP - 20191023 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*prevention & control/statistics & numerical data MH - *Automobile Driving MH - Built Environment MH - Computer Simulation MH - Humans MH - Models, Statistical MH - Probability OTO - NOTNLM OT - Block maxima OT - Multivariate EV distribution OT - Non-stationary model OT - Passing maneuvers OT - Road safety OT - Small probability estimation EDAT- 2019/11/02 06:00 MHDA- 2020/02/11 06:00 CRDT- 2019/11/01 06:00 PHST- 2018/03/12 00:00 [received] PHST- 2019/09/03 00:00 [revised] PHST- 2019/09/19 00:00 [accepted] PHST- 2019/11/02 06:00 [pubmed] PHST- 2020/02/11 06:00 [medline] PHST- 2019/11/01 06:00 [entrez] AID - S0001-4575(19)31388-0 [pii] AID - 10.1016/j.aap.2019.105315 [doi] PST - ppublish SO - Accid Anal Prev. 2020 Jan;134:105315. doi: 10.1016/j.aap.2019.105315. Epub 2019 Oct 23. PMID- 29345159 OWN - NLM STAT- MEDLINE DCOM- 20181127 LR - 20181127 IS - 1876-2891 (Electronic) IS - 1876-2883 (Linking) VI - 9 IP - 2 DP - 2018 Feb 27 TI - Weighing in on the risks and benefits of probiotic use in HIV-infected and immunocompromised populations. PG - 239-246 LID - 10.3920/BM2017.0106 [doi] AB - Probiotics are used in the prophylaxis and treatment of several conditions, including irritable bowel syndrome, diarrhoea, necrotising enterocolitis (NEC) and colic in infants. Despite the long history of probiotic use in humans, there is still significant debate about their efficacy and safety, particularly in HIV-infected and immunocompromised individuals. Here, we reviewed the safety and adverse event (AE) reporting from clinical trials that have tested probiotics in at risk populations, including HIV-infected individuals, the terminally ill and elderly, and neonates. Our analysis suggests that the benefits of probiotic therapy outweigh their potential risks in HIV-infected populations, and in the treatment of colic and NEC in low birth weight or premature neonates. Most case reports of severe AEs were in the elderly and terminally ill, or in those with additional severe medical conditions. We conclude that probiotic use, as adjunctive treatment, is effective and safe in the majority of patients including HIV-infected individuals, although special care should be taken in individuals with extreme immunosuppression and severe medical conditions in all ages. FAU - Happel, A U AU - Happel AU AD - 1 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925 Cape Town, South Africa. FAU - Barnabas, S L AU - Barnabas SL AD - 1 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925 Cape Town, South Africa. AD - 2 Desmond Tutu HIV Foundation, P.O. Box 13801, Mowbray, 7705 Cape Town, South Africa. FAU - Froissart, R AU - Froissart R AD - 3 Maladies infectieuses et vecteurs: écologie, génétique, évolution et contrôle (MIVEGEC) UMR 5290, CNRS, IRD, Université Montpellier, 911 Avenue Agropolis, 34394 Montpellier, France. FAU - Passmore, J S AU - Passmore JS AD - 1 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Medical School, Anzio Road, Observatory, 7925 Cape Town, South Africa. AD - 4 CAPRISA DST-NRF Centre of Excellence in HIV Prevention, University of KwaZulu-Natal, King George V Ave, Glenwood, Durban, 4041, South Africa. AD - 5 National Health Laboratory Service, Private Bag X8, Sandringham 2131, Johannesburg, South Africa. LA - eng PT - Journal Article PT - Review DEP - 20180118 PL - Netherlands TA - Benef Microbes JT - Beneficial microbes JID - 101507616 SB - IM MH - Drug-Related Side Effects and Adverse Reactions MH - Enterocolitis, Necrotizing/therapy MH - HIV Infections/*therapy MH - Humans MH - Immunocompromised Host/*immunology MH - Infant, Newborn MH - Infant, Newborn, Diseases/therapy MH - *Probiotics MH - Risk Assessment MH - Treatment Outcome OTO - NOTNLM OT - HIV OT - immunodeficiency OT - neonates OT - probiotics OT - safety EDAT- 2018/01/19 06:00 MHDA- 2018/11/28 06:00 CRDT- 2018/01/19 06:00 PHST- 2018/01/19 06:00 [pubmed] PHST- 2018/11/28 06:00 [medline] PHST- 2018/01/19 06:00 [entrez] AID - 10.3920/BM2017.0106 [doi] PST - ppublish SO - Benef Microbes. 2018 Feb 27;9(2):239-246. doi: 10.3920/BM2017.0106. Epub 2018 Jan 18. PMID- 26104648 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150827 LR - 20220410 IS - 2210-7797 (Electronic) IS - 2210-7789 (Linking) VI - 4 IP - 3 DP - 2014 Jul TI - Management of preeclampsia. PG - 246-7 LID - S2210-7789(14)00080-4 [pii] LID - 10.1016/j.preghy.2014.04.021 [doi] AB - Most patients with a pregnancy-induced hypertensive disorder have no clinical symptoms. So it can only be reliably detected by repetitive searches (screening) for the early signs and symptoms in the 2nd half of pregnancy. Adequate and proper prenatal care is the most important part of management of preeclampsia. Maternal antenatal monitoring includes identifying women at increased risk, early detection of preeclampsia by recognizing clinical signs and symptoms, and to observe progression of the condition to the severe state. As the etiology of preeclampsia remains in question, the only effective treatment is to deliver the infant and placenta; ancillary therapy is predominantly symptomatic and not directed at underlying causes. Once the diagnosis of preeclampsia is made, subsequent therapy will depend on the results of initial maternal and fetal evaluation. The primary objective of management of preeclampsia must always be safety of the mother. Although delivery is always appropriate for the mother, it may not be optimal for the fetus that is extremely premature. The decision between delivery and expectant management depends on fetal gestational age, maternal and fetal status at time of initial evaluation, presence of labor or rupture of fetal membranes, and level of available neonatal and maternal services. It is important to emphasize that hypertension is merely one manifestation of this disease, albeit directly related to one of the most serious consequences for the mother, i.e cerebral involvement, which may manifest itself as convulsions, focal neurological events such as cortical blindness, and even cerebral hemorrhage. The benefits of acute pharmacologic control of severe hypertension prior to delivery are generally accepted. The more contentious issues are the role of pharmacologic therapy in allowing prolongation of pregnancy and the ability of such therapy to modify the course of the underlying systemic disorder and affect fetal and maternal outcome. Ali hypertensive drugs affect both the mother and the fetus; some may produce side effects in the mother and others may produce adverse effects on the fetus or the newborn. The indirect effects of antihypertensive drugs on the fetus may be by impairing uteroplacental perfusion or directly by influencing the fetal cardiovascular circulation. In general, women with mild disease developing at 37weeks' gestation or longer have a pregnancy outcome similar to that found in normotensive pregnancy. Thus, those patients should undergo induction of labor for delivery. Induction of labor and/or delivery is also recommended for those at or beyond 34 weeks' gestation in the presence of severe preeclampsia, labor or rupture of membranes, or non-reassuring tests of fetal well-being because the mother is at slightly increased risk for development of placental abruption and progression to eclampsia. In women who remain undelivered, close maternal and fetal evaluation is essential. The type of test and frequency of evaluation will depend on fetal gestational age as well as severity of maternal condition, and presence or absence of IUGR. These tests should be repeated promptly in case of worsening maternal condition (progression to severe disease) or fetal condition (reduced fetal movement or suspected IUGR). Expectant management of severe preeclampsia:The clinical course of severe preeclampsia may be characterized by progressive deterioration in both maternal and fetal conditions. Because these pregnancies have been associated with increased rates of maternal morbidity and mortality and with significant risks for the fetus, there is universal agreement that such patients be delivered if the disease develops after 34weeks' gestational, 243. Delivery is also clearly indicated when there is imminent eclampsia (persistent severe symptoms), multiorgan dysfunction, severe IUGR, suspected placental abruption, or non-reassuring fetal testing before 34 weeks' gestation. There is disagreement however, about treatment of patients with severe preeclampsia before 34 weeks' gestation where maternal condition is stable and fetal condition is reassuring. The Cochrane review on interventionist versus expectant care states that it is not possible to draw firm conclusions, as there are only two small trials (133 women) that have compared a policy of early elective delivery, with a policy of delayed delivery, and the confidence intervals for all outcomes are wide. However, the evidence is promising that short-term morbidity for the baby may be reduced by a policy of expectant care. Sibai and Barton recently reviewed the literature on maternal and perinatal of expected management of severe preeclampsia remote from term and reviewed the major studies in the literature. Based on this review, they concluded that the results of these studies suggest that expectant treatment in a select group of women with severe preeclampsia between 24 0/7 and 32 6/7weeks of gestation in a suitable hospital is safe and improves neonatal outcome. Most studies on expectant management report 7-10days of prolongation. For gestational age of 24 0/7weeks, expectant treatment was associated with high maternal morbidity with limited perinatal benefit. CI - Copyright © 2014. FAU - Dekker, Gustaaf Albert AU - Dekker GA LA - eng PT - Journal Article DEP - 20140709 PL - Netherlands TA - Pregnancy Hypertens JT - Pregnancy hypertension JID - 101552483 EDAT- 2015/06/25 06:00 MHDA- 2015/06/25 06:01 CRDT- 2015/06/25 06:00 PHST- 2015/06/25 06:00 [entrez] PHST- 2015/06/25 06:00 [pubmed] PHST- 2015/06/25 06:01 [medline] AID - S2210-7789(14)00080-4 [pii] AID - 10.1016/j.preghy.2014.04.021 [doi] PST - ppublish SO - Pregnancy Hypertens. 2014 Jul;4(3):246-7. doi: 10.1016/j.preghy.2014.04.021. Epub 2014 Jul 9. PMID- 27115294 OWN - NLM STAT- MEDLINE DCOM- 20171017 LR - 20181113 IS - 1545-9632 (Electronic) IS - 1545-9624 (Print) IS - 1545-9624 (Linking) VI - 13 IP - 11 DP - 2016 Nov TI - Advancing the framework for considering the effects of climate change on worker safety and health. PG - 847-65 LID - 10.1080/15459624.2016.1179388 [doi] AB - In 2009, a preliminary framework for how climate change could affect worker safety and health was described. That framework was based on a literature search from 1988-2008 that supported seven categories of climate-related occupational hazards: (1) increased ambient temperature; (2) air pollution; (3) ultraviolet radiation exposure; (4) extreme weather; (5) vector-borne diseases and expanded habitats; (6) industrial transitions and emerging industries; and (7) changes in the built environment. This article reviews the published literature from 2008-2014 in each of the seven categories. Additionally, three new topics related to occupational safety and health are considered: mental health effects, economic burden, and potential worker safety and health impacts associated with the nascent field of climate intervention (geoengineering). Beyond updating the literature, this article also identifies key priorities for action to better characterize and understand how occupational safety and health may be associated with climate change events and ensure that worker health and safety issues are anticipated, recognized, evaluated, and mitigated. These key priorities include research, surveillance, risk assessment, risk management, and policy development. Strong evidence indicates that climate change will continue to present occupational safety and health hazards, and this framework may be a useful tool for preventing adverse effects to workers. FAU - Schulte, P A AU - Schulte PA AD - a National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Education and Infomation Division , Cincinnati , Ohio. FAU - Bhattacharya, A AU - Bhattacharya A AD - a National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Education and Infomation Division , Cincinnati , Ohio. FAU - Butler, C R AU - Butler CR AD - b Western States Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Denver , Colorado. FAU - Chun, H K AU - Chun HK AD - c Georgia Southern University, College of Public Health , Statesboro , Georgia. FAU - Jacklitsch, B AU - Jacklitsch B AD - a National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Education and Infomation Division , Cincinnati , Ohio. FAU - Jacobs, T AU - Jacobs T AD - d Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Cincinnati , Ohio. FAU - Kiefer, M AU - Kiefer M AD - b Western States Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Denver , Colorado. FAU - Lincoln, J AU - Lincoln J AD - e Western States Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Anchorage , Alaska. FAU - Pendergrass, S AU - Pendergrass S AD - a National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Education and Infomation Division , Cincinnati , Ohio. FAU - Shire, J AU - Shire J AD - d Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Cincinnati , Ohio. FAU - Watson, J AU - Watson J AD - f Western States Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Spokane , Washington. FAU - Wagner, G R AU - Wagner GR AD - g Office of the Director, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention ; Washington , D.C. LA - eng GR - CC999999/Intramural CDC HHS/United States PT - Journal Article PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - *Climate Change MH - Geography MH - Humans MH - Occupational Exposure/*analysis MH - Occupational Health/*trends MH - Risk Assessment MH - *Temperature MH - United States PMC - PMC5017900 MID - NIHMS798434 OID - NLM: HHSPA798434 [Available on 11/01/16] OTO - NOTNLM OT - Extreme weather OT - occupational safety and health OT - risk assessment OT - temperature EDAT- 2016/04/27 06:00 MHDA- 2017/10/19 06:00 PMCR- 2016/10/13 CRDT- 2016/04/27 06:00 PHST- 2016/04/27 06:00 [entrez] PHST- 2016/04/27 06:00 [pubmed] PHST- 2017/10/19 06:00 [medline] PHST- 2016/10/13 00:00 [pmc-release] AID - 1179388 [pii] AID - 10.1080/15459624.2016.1179388 [doi] PST - ppublish SO - J Occup Environ Hyg. 2016 Nov;13(11):847-65. doi: 10.1080/15459624.2016.1179388. PMID- 38862050 OWN - NLM STAT- MEDLINE DCOM- 20240706 LR - 20240706 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 273 IP - Pt 1 DP - 2024 Jul TI - Extreme condition-tolerant stretchable flexible supercapacitor and triboelectric nanogenerator based on carrageenan-enhanced gel for energy storage, energy collection and self-powered sensing. PG - 132994 LID - S0141-8130(24)03799-1 [pii] LID - 10.1016/j.ijbiomac.2024.132994 [doi] AB - As flexible electronics devices for energy storage, mechanical energy collection and self-powered sensing, stretchable flexible supercapacitor and triboelectric nanogenerator (TENG) have attracted extensive attention. However, it is difficult to satisfy the requirements of high safety and resistance to extreme conditions. Dual roles of mechanical and electrical enhancement of inorganic salt are put forward, and a carrageenan (CG) enhanced poly (N-hydroxyethyl acrylamide)/CG/lithium chloride/glycerol (PCLG) conductive gel is prepared by designing hydrogen bonding self-crosslinking and chain entanglement. A high concentration and rapid deposition strategy is proposed to prepare a PCLG gel-based stretchable flexible all-in-one supercapacitor for energy storage, and a single electrode PCLG gel-based TENG is designed for mechanical energy collection, self-powered strain and tactile sensing. The supercapacitor has high capacitance, excellent cycling stability. The TENG possesses efficient energy harvesting with high and stable output voltage and power density, and sensitive and stable self-powered strain and tactile sensing without external power supply. Even under extreme conditions such as low temperatures, self-healing after damage, prolonged placement, deformation, post-deformation, multiple continuous work, pinprick and burning, the supercapacitor and TENG still have excellent properties. Therefore, we provide novel ideas to design flexible supercapacitor and TENG used under extreme conditions for future wearable electronics. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Li, Zhenyang AU - Li Z AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Zhang, Huijuan AU - Zhang H AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Li, Chenyu AU - Li C AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Tian, Xiyu AU - Tian X AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Liu, Shuzheng AU - Liu S AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Qin, Gang AU - Qin G AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China. FAU - Yang, Jia AU - Yang J AD - School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454003, PR China; Aeolus Tyre Co., Ltd., Jiaozuo 454003, PR China. Electronic address: jiangshanjia@hpu.edu.cn. FAU - Chen, Qiang AU - Chen Q AD - Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, PR China. Electronic address: chenqiang@ucas.ac.cn. LA - eng PT - Journal Article DEP - 20240609 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 9000-07-1 (Carrageenan) RN - 0 (Gels) SB - IM MH - *Carrageenan/chemistry MH - *Electric Capacitance MH - *Electric Power Supplies MH - *Gels/chemistry MH - Wearable Electronic Devices MH - Nanotechnology OTO - NOTNLM OT - Carrageenan-enhanced gel OT - Stretchable all-in-one supercapacitor OT - Triboelectric nanogenerator COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/06/12 00:41 MHDA- 2024/07/06 20:42 CRDT- 2024/06/11 19:17 PHST- 2024/04/18 00:00 [received] PHST- 2024/05/27 00:00 [revised] PHST- 2024/06/05 00:00 [accepted] PHST- 2024/07/06 20:42 [medline] PHST- 2024/06/12 00:41 [pubmed] PHST- 2024/06/11 19:17 [entrez] AID - S0141-8130(24)03799-1 [pii] AID - 10.1016/j.ijbiomac.2024.132994 [doi] PST - ppublish SO - Int J Biol Macromol. 2024 Jul;273(Pt 1):132994. doi: 10.1016/j.ijbiomac.2024.132994. Epub 2024 Jun 9. PMID- 32480015 OWN - NLM STAT- MEDLINE DCOM- 20201005 LR - 20201005 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 143 DP - 2020 Aug TI - Are collision and crossing course surrogate safety indicators transferable? A probability based approach using extreme value theory. PG - 105517 LID - S0001-4575(19)31073-5 [pii] LID - 10.1016/j.aap.2020.105517 [doi] AB - In order to overcome the shortcomings of crash data a number of surrogate measures of safety have been developed and proposed by various researchers. One of the most widely used temporal indicators is time-to-collision (TTC) which requires the road users to be on a collision course. Road users that are strictly speaking not on a collision course actually might behave and take evasive actions as if they were, thus indicating that such near-miss situations might also be relevant for safety analysis. Taking that into account, a more flexible indicator T(2), which does not require the two vehicles to be on a collision course, describes the expected time for the second road user to arrive at the conflict point. Recently extreme value theory (EVT) offering two approaches, block maxima (BM) and Peak over Threshold (POT), has been applied in combination with surrogate indicators to estimate crash probabilities. Most of this research has focused on testing BM and POT as well as validating various surrogate safety indicators by comparing model estimates to actual crash frequencies. The comparison of collision course indicators with indicators including crossing course interactions and their performance using EVT has not been investigated yet. In this study we are seeking answers to under what conditions these indicators perform better and whether they are transferable. Using data gathered at a signalized intersection focusing on left-turning and straight moving vehicle interactions our analysis concluded that the two indicators are transferable with stricter threshold values for T(2) and that POT gives more reasonable results. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Borsos, Attila AU - Borsos A AD - University of Győr, Department of Transport Infrastructure and Water Resources Engineering, Egyetem tér 1, Győr 9026, Hungary. Electronic address: borsosa@sze.hu. FAU - Farah, Haneen AU - Farah H AD - Delft University of Technology, Department of Transport and Planning, Stevinweg 1, 2628 CN Delft, Netherlands. Electronic address: H.Farah@tudelft.nl. FAU - Laureshyn, Aliaksei AU - Laureshyn A AD - Lund University, Department of Technology and Society, John Ericssons vag 1, 1 TR Lund, Sweden. Electronic address: aliaksei.laureshyn@tft.lth.se. FAU - Hagenzieker, Marjan AU - Hagenzieker M AD - Delft University of Technology, Department of Transport and Planning, Stevinweg 1, 2628 CN Delft, Netherlands. Electronic address: m.p.hagenzieker@tudelft.nl. LA - eng PT - Journal Article DEP - 20200529 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*prevention & control MH - *Automobile Driving MH - Humans MH - Probability MH - Risk Management OTO - NOTNLM OT - Collision and crossing course OT - Crash probability OT - Extreme value theory OT - Surrogate measures of safety EDAT- 2020/06/02 06:00 MHDA- 2020/10/06 06:00 CRDT- 2020/06/02 06:00 PHST- 2019/08/20 00:00 [received] PHST- 2020/02/23 00:00 [revised] PHST- 2020/03/17 00:00 [accepted] PHST- 2020/06/02 06:00 [pubmed] PHST- 2020/10/06 06:00 [medline] PHST- 2020/06/02 06:00 [entrez] AID - S0001-4575(19)31073-5 [pii] AID - 10.1016/j.aap.2020.105517 [doi] PST - ppublish SO - Accid Anal Prev. 2020 Aug;143:105517. doi: 10.1016/j.aap.2020.105517. Epub 2020 May 29. PMID- 16412107 OWN - NLM STAT- MEDLINE DCOM- 20060509 LR - 20141120 IS - 1195-1982 (Print) IS - 1195-1982 (Linking) VI - 13 IP - 1 DP - 2006 Jan-Feb TI - Drugs and drug administration in extreme environments. PG - 35-47 AB - Emergency medicine must often cope with harsh climates far below freezing point or high temperatures, and sometimes, an alternative to the normal route of drug administration is necessary. Most of this information is not yet published. Therefore, we summarized the information about these topics for most drugs used in medical emergencies by combining literature research with extensive personal communications with the heads of the drug safety departments of the companies producing these drugs. Most drugs can be used after temperature stress of limited duration. Nevertheless, we recommend replacing them at least once per year or after extreme heat. Knowledge about drugs used in extreme environments will be of increasing importance for medical personnel because in an increasingly mobile society, more and more people, and especially elderly -often with individual medical risks-travel to extreme regions such as tropical or arctic regions or to high altitude, and some of them need medical care during these activities. Because of this increasing need to use drugs in harsh climates (tourism, expeditions, peace corps, military, etc) the actual International Congress of Harmonization recommendations should be added with stability tests at +50 degrees C, freezing and oscillating temperatures, and UV exposure to simulate the storage of the drugs at "outdoor conditions." FAU - Küpper, Thomas E A H AU - Küpper TE AD - Institute of Aerospace Medicine, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. FAU - Schraut, Bettina AU - Schraut B FAU - Rieke, Burkhard AU - Rieke B FAU - Hemmerling, Arnica-Verena AU - Hemmerling AV FAU - Schöffl, Volker AU - Schöffl V FAU - Steffgen, Juergen AU - Steffgen J LA - eng PT - Journal Article PT - Review PL - England TA - J Travel Med JT - Journal of travel medicine JID - 9434456 SB - IM CIN - J Travel Med. 2006 Jul-Aug;13(4):248; author reply 248-9. doi: 10.1111/j.1708-8305.2006.00052.x. PMID: 16884410 MH - Climate MH - *Drug Administration Routes MH - Drug Labeling MH - *Drug Packaging MH - *Drug Stability MH - *Drug Storage MH - Emergency Medical Services MH - Global Health MH - *Health Knowledge, Attitudes, Practice MH - Humans MH - *Temperature MH - Tropical Climate RF - 57 EDAT- 2006/01/18 09:00 MHDA- 2006/05/10 09:00 CRDT- 2006/01/18 09:00 PHST- 2006/01/18 09:00 [pubmed] PHST- 2006/05/10 09:00 [medline] PHST- 2006/01/18 09:00 [entrez] AID - JTM7 [pii] AID - 10.1111/j.1708-8305.2006.00007.x [doi] PST - ppublish SO - J Travel Med. 2006 Jan-Feb;13(1):35-47. doi: 10.1111/j.1708-8305.2006.00007.x. PMID- 22580490 OWN - NLM STAT- MEDLINE DCOM- 20121023 LR - 20121105 IS - 1537-8918 (Electronic) IS - 1537-890X (Linking) VI - 11 IP - 3 DP - 2012 May-Jun TI - Lightning and severe thunderstorms in event management. PG - 131-4 LID - 10.1249/JSR.0b013e3182563e95 [doi] AB - There are a few national position stands/guidelines that address environmental conditions in athletics, yet they do not govern all outdoor sports. Extreme heat and cold, lightning, and severe wind can all be fatal, yet the majority of outdoor sports have no published guidelines addressing these conditions in relation to activity. Available research on extreme heat and cold conditions in athletics provides prevention strategies, to include acclimatization. Lightning and severe wind are two environmental conditions to which humans cannot accommodate, and they both can be deadly. There are strong positions on extreme heat/cold and lightning safety in athletics, but none affiliated with severe winds. Medical personnel involved in planning large outdoor sporting events must know of the presence of nationally published weather-related documents and apply them to their event. In addition, research needs to be expanded in the realm of establishing guidelines for safety to participants and spectators in severe wind conditions. FAU - Walsh, Katie M AU - Walsh KM AD - 245 Ward Sports Medicine Building, East Carolina University, Greenville, NC 27858, USA. Walshk@ecu.edu LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Sports Med Rep JT - Current sports medicine reports JID - 101134380 SB - IM MH - Anniversaries and Special Events MH - Guidelines as Topic MH - Humans MH - *Lightning MH - Safety/*standards MH - *Sports MH - *Wind EDAT- 2012/05/15 06:00 MHDA- 2012/10/24 06:00 CRDT- 2012/05/15 06:00 PHST- 2012/05/15 06:00 [entrez] PHST- 2012/05/15 06:00 [pubmed] PHST- 2012/10/24 06:00 [medline] AID - 00149619-201205000-00008 [pii] AID - 10.1249/JSR.0b013e3182563e95 [doi] PST - ppublish SO - Curr Sports Med Rep. 2012 May-Jun;11(3):131-4. doi: 10.1249/JSR.0b013e3182563e95. PMID- 33301841 OWN - NLM STAT- MEDLINE DCOM- 20210205 LR - 20210205 IS - 1532-2939 (Electronic) IS - 0195-6701 (Print) IS - 0195-6701 (Linking) VI - 108 DP - 2021 Feb TI - Heat stress and PPE during COVID-19: impact on healthcare workers' performance, safety and well-being in NHS settings. PG - 185-188 LID - S0195-6701(20)30551-X [pii] LID - 10.1016/j.jhin.2020.11.027 [doi] AB - Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its consequences. Respondents reported experiencing several heat-related illness symptoms, and heat stress impaired both cognitive and physical performance. The majority of respondents stated that wearing PPE made their job more difficult. These, and additional, responses suggest that modification to current working practices is required urgently to improve the resilience of HCWs to wearing PPE during pandemics. CI - Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved. FAU - Davey, S L AU - Davey SL AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. Electronic address: ad4782@coventry.ac.uk. FAU - Lee, B J AU - Lee BJ AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. FAU - Robbins, T AU - Robbins T AD - University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK; Institute of Digital Healthcare, WMG, University of Warwick, Coventry, UK. FAU - Randeva, H AU - Randeva H AD - University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK. FAU - Thake, C D AU - Thake CD AD - Occupational and Environmental Physiology Group, Centre for Sport, Exercise and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, UK. LA - eng PT - Journal Article DEP - 20201207 PL - England TA - J Hosp Infect JT - The Journal of hospital infection JID - 8007166 SB - IM MH - Adult MH - COVID-19/diagnosis/epidemiology/prevention & control/virology MH - Cognitive Dysfunction/etiology MH - Extreme Environments MH - Female MH - Health Personnel/*psychology/statistics & numerical data MH - Heat-Shock Response/*physiology MH - Humans MH - Male MH - Middle Aged MH - Perception/physiology MH - Personal Protective Equipment/*adverse effects MH - SARS-CoV-2/genetics MH - Safety MH - State Medicine/organization & administration MH - Surveys and Questionnaires/statistics & numerical data MH - United Kingdom/epidemiology MH - Work Performance/*statistics & numerical data PMC - PMC7720696 OTO - NOTNLM OT - COVID-19 OT - Extreme environments OT - Healthcare workers OT - Heat stress OT - Heat-related illness OT - Personal protective equipment OT - SARS-CoV-2 EDAT- 2020/12/11 06:00 MHDA- 2021/02/07 06:00 PMCR- 2020/12/07 CRDT- 2020/12/10 20:09 PHST- 2020/10/12 00:00 [received] PHST- 2020/11/25 00:00 [revised] PHST- 2020/11/27 00:00 [accepted] PHST- 2020/12/11 06:00 [pubmed] PHST- 2021/02/07 06:00 [medline] PHST- 2020/12/10 20:09 [entrez] PHST- 2020/12/07 00:00 [pmc-release] AID - S0195-6701(20)30551-X [pii] AID - 10.1016/j.jhin.2020.11.027 [doi] PST - ppublish SO - J Hosp Infect. 2021 Feb;108:185-188. doi: 10.1016/j.jhin.2020.11.027. Epub 2020 Dec 7. PMID- 34466938 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210903 IS - 2639-6378 (Electronic) IS - 2639-6378 (Linking) VI - 3 IP - 5 DP - 2017 Oct TI - Safeguarding Worker Health and Safety from a Changing Climate:: Delaware's Climate-Ready Workforce Pilot Project. PG - 14-22 LID - 10.32481/djph.2017.10.005 [doi] AB - Changing climate conditions threaten the health and safety of the State of Delaware's most important assets: its workforce. Building on momentum at the state level to assess climate risks and implement relevant adaptation actions, five state agencies implemented the Climate- Ready Workforce Pilot Project to identify and safeguard at-risk workers from the impacts of extreme events such as storms and floods as well as extreme temperatures. Findings indicate that the five participating agencies have an important foundation of worker health and safety policies, procedures and practices. Enhancing their climate resilience will require both strengthening the fundamentals of current policies and procedures by improving processes for policy development, implementation, and enforcement, more explicitly incorporating climate considerations, and sharing agency good practices are key actions. FAU - Kim, Yoon AU - Kim Y AD - Four Twenty Seven. FAU - Yandrich, Kerri AU - Yandrich K AD - Delaware Department of Natural Resources and Environmental Control. FAU - DeMooy, Jennifer AU - DeMooy J AD - Delaware Department of Natural Resources and Environmental Control. FAU - Starkman, Kendall AU - Starkman K AD - Four Twenty Seven. LA - eng PT - Journal Article DEP - 20171025 PL - United States TA - Dela J Public Health JT - Delaware journal of public health JID - 101769648 PMC - PMC8389707 EDAT- 2017/10/25 00:00 MHDA- 2017/10/25 00:01 PMCR- 2017/10/25 CRDT- 2021/09/01 07:30 PHST- 2021/09/01 07:30 [entrez] PHST- 2017/10/25 00:00 [pubmed] PHST- 2017/10/25 00:01 [medline] PHST- 2017/10/25 00:00 [pmc-release] AID - djph-35-005 [pii] AID - 10.32481/djph.2017.10.005 [doi] PST - epublish SO - Dela J Public Health. 2017 Oct 25;3(5):14-22. doi: 10.32481/djph.2017.10.005. eCollection 2017 Oct. PMID- 36676585 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230123 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 16 IP - 2 DP - 2023 Jan 15 TI - Study on Mechanical Failure Behavior of Steel-Wire Wound Reinforced Thermoplastic Pipe under Combined Internal Pressure and Soil Landslide Conditions. LID - 10.3390/ma16020848 [doi] LID - 848 AB - A steel-wire wound reinforced thermoplastic pipe (SWW-RTP) has been widely utilized in many industrial areas, and a soil landslide is an inevitable hazardous extreme condition for the SWW-RTP as it is usually buried underground. It is imperative to study the mechanical failure behavior and the failure criterion of the SWW-RTP under the combination of internal pressure and soil landslide conditions, and this paper is the first study to investigate the topic. In this paper, groups of stress-strain curves of high-density polyethylene (HDPE) and steel wires were obtained by uniaxial tensile tests at different strain rates, with the help of a Digital Image Correlation device (DIC). A rate-dependent constitutive model was employed to represent the mechanical behavior of the HDPE and to help deduce the stress-strain curve of the HDPE under the required strain rate, estimated from the static simplification of the dynamic soil landslide. Afterwards, a finite element model of the SWW-RTP, embedded in a cubic of soil, was established with the software ABAQUS. The SWW-RTP model was composed of HDPE solid elements, embedded with steel-wire truss elements, and the soil was characterized with the extended Drucker-Prager model. A quartic polynomial displacement distribution was applied to the soil model to represent the soil landslide. Then, the mechanical response of the SWW-RTP was analyzed. It was found that the failure criterion of the HDPE yield was more suitable for the pipe subjected to internal pressure and soil landslide conditions, instead of the steel-wire strength failure criterion always used in traditional research on the SWW-RTP. Further, the influence of landslide width, internal pressure and steel-wire number were discussed. The larger the width of the landslide area, the gentler the deformation of the pipeline; this resulted in an increase in the maximum landslide and a decrease in the maximum curvature with the width of the landslide area. The relatively high internal pressure was beneficial to the safety of the SWW-RTP under landslide, because the internal pressure could increase the stiffness of the pipeline. The number of steel wires had a limited influence on the maximum landslide required for the SWW-RTP's failure. This work can be useful for the design and safe assessment of the SWW-RTP under internal pressure and soil landslide conditions. FAU - Shi, Jun AU - Shi J AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. AD - Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430205, China. FAU - Hu, Zhijie AU - Hu Z AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. FAU - Zeng, Li AU - Zeng L AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. AD - Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430205, China. FAU - Lu, Panlin AU - Lu P AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. FAU - Chen, Hanxin AU - Chen H AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. FAU - Yu, Nanming AU - Yu N AUID- ORCID: 0000-0002-9965-5693 AD - Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430074, China. AD - Hubei Provincial Engineering Technology Research Center of Green Chemical Equipment, School of Mechanical and Electrical Engineering, Wuhan Institute of Technology, Wuhan 430205, China. FAU - Li, Xiang AU - Li X AD - Department of Pressure Vessel, China Special Equipment Inspection & Research Institute, Beijing 100029, China. LA - eng GR - No.51805378/the National Natural Science Foundation of China/ GR - No. 2019010701011417/the Foundation of Wuhan Science and Technology Bureau/ GR - Grant No. 2017KA01, 2018KA02, 2021KA05/the Open Research Fund Program of Hubei Provincial Key Laboratory of Chemical Equipment Intensification and Intrinsic Safety/ GR - Grant No. K201710/the research fund of Wuhan Institute of Technology/ PT - Journal Article DEP - 20230115 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC9866405 OTO - NOTNLM OT - finite element analysis OT - internal pressure OT - landslide OT - reinforced thermoplastic pipe OT - structural failure COIS- The authors declare no conflict of interest. EDAT- 2023/01/22 06:00 MHDA- 2023/01/22 06:01 PMCR- 2023/01/15 CRDT- 2023/01/21 01:36 PHST- 2022/11/25 00:00 [received] PHST- 2023/01/07 00:00 [revised] PHST- 2023/01/11 00:00 [accepted] PHST- 2023/01/21 01:36 [entrez] PHST- 2023/01/22 06:00 [pubmed] PHST- 2023/01/22 06:01 [medline] PHST- 2023/01/15 00:00 [pmc-release] AID - ma16020848 [pii] AID - materials-16-00848 [pii] AID - 10.3390/ma16020848 [doi] PST - epublish SO - Materials (Basel). 2023 Jan 15;16(2):848. doi: 10.3390/ma16020848. PMID- 32043808 OWN - NLM STAT- MEDLINE DCOM- 20210330 LR - 20210330 IS - 1752-699X (Electronic) IS - 1752-6981 (Linking) VI - 14 IP - 6 DP - 2020 Jun TI - The effectiveness, safety and compliance of Zheng's supine rehabilitation exercise as a rehabilitation programme among elderly patients with AECOPD. PG - 533-540 LID - 10.1111/crj.13164 [doi] AB - PURPOSE: We investigated the effectiveness, safety and compliance of Zheng's Supine Rehabilitation Exercise (ZSRE) as a rehabilitation programme among elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). PATIENTS AND METHODS: About 82 elderly patients with AECOPD were divided into a rehabilitation group and control group on their admission day, and both groups received routine medical treatment. Patients in the rehabilitation group started ZSRE on the second day of admission and continued until 8 weeks after discharge. RESULTS: At the 9th week after discharge, the COPD Assessment Test (CAT), 6-minute walking distance (6MWD) and Modified Medical Research Council Dyspnea Scale (mMRC) in the rehabilitation group were all significantly better than those in the control group (P < 0.01; P < 0.01; and P < 0.05, respectively). In the rehabilitation group, the CAT and 6MWD were significantly improved in the 9th week after discharge as compared with those at admission or discharge, and mMRC was significantly improved at the 9th week after discharge as compared with that at admission (all P < 0.01). CONCLUSION: ZSRE can be performed by elderly patients with the acute exacerbation of severe or extremely severe COPD with high safety and compliance and was helpful for their recovery. CI - © 2020 John Wiley & Sons Ltd. FAU - Lu, Haonan AU - Lu H AUID- ORCID: 0000-0002-4308-9194 AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. AD - Hexian Memorial Hospital of Panyu District, Guangzhou, China. FAU - Liu, Ni AU - Liu N AUID- ORCID: 0000-0003-1024-305X AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Hu, Jie Ying AU - Hu JY AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Wang, Xinni AU - Wang X AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Li, Youxia AU - Li Y AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Song, Mali AU - Song M AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Zhong, Li Hong AU - Zhong LH AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - He, Wei AU - He W AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Chen, RongChang AU - Chen R AUID- ORCID: 0000-0001-7642-3921 AD - Shenzhen Institute of Respiratory Diseases, Shenzhen City, China. FAU - Zheng, Zeguang AU - Zheng Z AD - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. LA - eng GR - 30971317/The national natural science foundation of China/ GR - 2016YFC1304600/The 13th five-year research and development project of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20200312 PL - England TA - Clin Respir J JT - The clinical respiratory journal JID - 101315570 SB - IM MH - Aged MH - Case-Control Studies MH - Disease Progression MH - Exercise Therapy/*methods MH - Hospitalization/statistics & numerical data MH - Humans MH - Male MH - Middle Aged MH - Patient Compliance/statistics & numerical data MH - Pulmonary Disease, Chronic Obstructive/*physiopathology/*rehabilitation MH - Recovery of Function/physiology MH - Respiratory Function Tests/methods/statistics & numerical data MH - Safety MH - Supine Position/*physiology MH - Treatment Outcome MH - Walk Test/methods/statistics & numerical data OTO - NOTNLM OT - chronic obstructive pulmonary disease (COPD) OT - pulmonary rehabilitation EDAT- 2020/02/12 06:00 MHDA- 2021/03/31 06:00 CRDT- 2020/02/12 06:00 PHST- 2019/04/25 00:00 [received] PHST- 2020/01/03 00:00 [revised] PHST- 2020/02/06 00:00 [accepted] PHST- 2020/02/12 06:00 [pubmed] PHST- 2021/03/31 06:00 [medline] PHST- 2020/02/12 06:00 [entrez] AID - 10.1111/crj.13164 [doi] PST - ppublish SO - Clin Respir J. 2020 Jun;14(6):533-540. doi: 10.1111/crj.13164. Epub 2020 Mar 12. PMID- 36799415 OWN - NLM STAT- MEDLINE DCOM- 20230601 LR - 20230601 IS - 2589-9783 (Electronic) IS - 2589-9775 (Linking) VI - 15 IP - 3 DP - 2023 TI - Herbal Approach for Diabetic Cure and Futuristic Dimension. PG - 207-221 LID - 10.2174/2589977515666230217114449 [doi] AB - Engulfing almost 537 million people, the most commonly occurring metabolic disorder, diabetes mellitus, is emerging as an epidemic worldwide. Diabetes mellitus is identified as a heterogeneous pathological condition that is marked by extreme hyperglycemic (glucose) levels caused by reduced insulin sensitivity. Synthetic antidiabetic medications are widely commercialized but have slowly expressed several inevitable side effects and limitations in treated diabetic subjects. Researchers have been exploring herbal medicine due to its esteemed therapeutic effects. WHO have enlisted almost 21,000 herbal components that have established therapeutic benefit. Several herbs, most of them widely available, have been studied to extract their active phytoconstituents that have effective diabetes management potential with the least risk factor for side effects and acute toxicity. Though acceptable standardization, awareness, and clinical trials are yet to be established before mainstreaming herbal formulation, preclinical studies have confirmed the higher safety and efficacy of several extracted phytoconstituents and formulation in comparative analysis with synthetic products. The authors have also discussed their opinions with regard to the vast usability of herbal components along with the multi-target functionality of several phytoconstituents, as well as the challenges faced for standardizing, formulating, and marketing herbal medicines. Other than this, several cases of clinical trials showing effectivity of herbal antidiabetic aid are mentioned. In this review, an attempt has been made to summarize the potential antidiabetic herbs, marketed herbal formulations, and patented formulations that have established therapeutic prospects to downregulate diabetic conditions. CI - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Singh, Jangjeet Karan AU - Singh JK AD - Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, India. FAU - Chakraborty, Snigdha AU - Chakraborty S AD - Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, India. FAU - Nagpal, Manju AU - Nagpal M AD - Chitkara College of Pharmacy, Chitkara University, Punjab, Rajpura, India. FAU - Aggarwal, Geeta AU - Aggarwal G AD - Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, New Delhi, India. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Drug Res Rev JT - Current drug research reviews JID - 101735701 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Humans MH - *Diabetes Mellitus/drug therapy/chemically induced MH - Hypoglycemic Agents/pharmacology/therapeutic use MH - *Plants, Medicinal MH - Herbal Medicine MH - Insulin/therapeutic use OTO - NOTNLM OT - Phytoconstituents OT - diabetes OT - herbal medicine OT - hyperglycemic OT - insulin OT - pancreatic tonic EDAT- 2023/02/18 06:00 MHDA- 2023/06/01 06:42 CRDT- 2023/02/17 07:03 PHST- 2022/07/23 00:00 [received] PHST- 2022/11/16 00:00 [revised] PHST- 2022/11/29 00:00 [accepted] PHST- 2023/06/01 06:42 [medline] PHST- 2023/02/18 06:00 [pubmed] PHST- 2023/02/17 07:03 [entrez] AID - CDRR-EPUB-129578 [pii] AID - 10.2174/2589977515666230217114449 [doi] PST - ppublish SO - Curr Drug Res Rev. 2023;15(3):207-221. doi: 10.2174/2589977515666230217114449. PMID- 24227352 OWN - NLM STAT- MEDLINE DCOM- 20140107 LR - 20181202 IS - 1365-2168 (Electronic) IS - 0007-1323 (Linking) VI - 100 IP - 13 DP - 2013 Dec TI - Communication in the operating theatre. PG - 1677-88 LID - 10.1002/bjs.9332 [doi] AB - BACKGROUND: Communication is extremely important to ensure safe and effective clinical practice. A systematic literature review of observational studies addressing communication in the operating theatre was conducted. The focus was on observational studies alone in order to gain an understanding of actual communication practices, rather than what was reported through recollections and interviews. METHODS: A systematic review of the literature for accessible published and grey literature was performed in July 2012. The following information was extracted: year, country, objectives, methods, study design, sample size, healthcare professional focus and main findings. Quality appraisal was conducted using the Critical Appraisal Skills Programme. A meta-ethnographic approach was used to categorize further the main findings under key concepts. RESULTS: Some 1174 citations were retrieved through an electronic database search, reference lists and known literature. Of these, 26 were included for review after application of full-text inclusion and exclusion criteria. The overall quality of the studies was rated as average to good, with 77 per cent of the methodological quality assessment criteria being met. Six key concepts were identified: signs of effective communication, signs of communication problems, effects on teamwork, conditions for communication, effects on patient safety and understanding collaborative work. CONCLUSION: Communication was shown to affect operating theatre practices in all of the studies reviewed. Further detailed observational research is needed to gain a better understanding of how to improve the working environment and patient safety in theatre. CI - © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons Ltd. FAU - Weldon, S-M AU - Weldon SM AD - Department of Surgery and Cancer, Imperial College London. FAU - Korkiakangas, T AU - Korkiakangas T FAU - Bezemer, J AU - Bezemer J FAU - Kneebone, R AU - Kneebone R LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review PL - England TA - Br J Surg JT - The British journal of surgery JID - 0372553 SB - IM MH - Clinical Competence/standards MH - *Communication MH - Cooperative Behavior MH - General Surgery/*standards MH - Group Processes MH - Humans MH - Interprofessional Relations MH - Observational Studies as Topic MH - *Operating Rooms MH - Patient Care Team/organization & administration/standards MH - Patient Safety MH - Prospective Studies EDAT- 2013/11/15 06:00 MHDA- 2014/01/08 06:00 CRDT- 2013/11/15 06:00 PHST- 2013/09/13 00:00 [accepted] PHST- 2013/11/15 06:00 [entrez] PHST- 2013/11/15 06:00 [pubmed] PHST- 2014/01/08 06:00 [medline] AID - 10.1002/bjs.9332 [doi] PST - ppublish SO - Br J Surg. 2013 Dec;100(13):1677-88. doi: 10.1002/bjs.9332. PMID- 25303833 OWN - NLM STAT- MEDLINE DCOM- 20160118 LR - 20150502 IS - 1769-7123 (Electronic) IS - 0923-2508 (Linking) VI - 166 IP - 4 DP - 2015 May TI - Mechanisms of food processing and storage-related stress tolerance in Clostridium botulinum. PG - 344-52 LID - S0923-2508(14)00191-0 [pii] LID - 10.1016/j.resmic.2014.09.011 [doi] AB - Vegetative cultures of Clostridium botulinum produce the extremely potent botulinum neurotoxin, and may jeopardize the safety of foods unless sufficient measures to prevent growth are applied. Minimal food processing relies on combinations of mild treatments, primarily to avoid deterioration of the sensory qualities of the food. Tolerance of C. botulinum to minimal food processing is well characterized. However, data on effects of successive treatments on robustness towards further processing is lacking. Developments in genetic manipulation tools and the availability of annotated genomes have allowed identification of genetic mechanisms involved in stress tolerance of C. botulinum. Most studies focused on low temperature, and the importance of various regulatory mechanisms in cold tolerance of C. botulinum has been demonstrated. Furthermore, novel roles in cold tolerance were shown for metabolic pathways under the control of these regulators. A role for secondary oxidative stress in tolerance to extreme temperatures has been proposed. Additionally, genetic mechanisms related to tolerance to heat, low pH, and high salinity have been characterized. Data on genetic stress-related mechanisms of psychrotrophic Group II C. botulinum strains are scarce; these mechanisms are of interest for food safety research and should thus be investigated. This minireview encompasses the importance of C. botulinum as a food safety hazard and its central physiological characteristics related to food-processing and storage-related stress. Special attention is given to recent findings considering genetic mechanisms C. botulinum utilizes in detecting and countering these adverse conditions. CI - Copyright © 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. FAU - Dahlsten, Elias AU - Dahlsten E AD - Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, P. O. Box 66, FI-00014 Helsinki, Finland. Electronic address: elias.dahlsten@helsinki.fi. FAU - Lindström, Miia AU - Lindström M AD - Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, P. O. Box 66, FI-00014 Helsinki, Finland. Electronic address: miia.lindstrom@helsinki.fi. FAU - Korkeala, Hannu AU - Korkeala H AD - Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, P. O. Box 66, FI-00014 Helsinki, Finland. Electronic address: hannu.korkeala@helsinki.fi. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20141007 PL - France TA - Res Microbiol JT - Research in microbiology JID - 8907468 SB - IM MH - Clostridium botulinum/drug effects/*physiology/radiation effects MH - *Food Handling MH - *Food Microbiology MH - Hydrogen-Ion Concentration MH - Salinity MH - *Stress, Physiological MH - Temperature OTO - NOTNLM OT - Clostridium botulinum OT - Cold-shock response OT - Food processing OT - Foodborne botulism OT - Heat-shock response EDAT- 2014/10/12 06:00 MHDA- 2016/01/19 06:00 CRDT- 2014/10/12 06:00 PHST- 2014/07/24 00:00 [received] PHST- 2014/09/26 00:00 [revised] PHST- 2014/09/26 00:00 [accepted] PHST- 2014/10/12 06:00 [entrez] PHST- 2014/10/12 06:00 [pubmed] PHST- 2016/01/19 06:00 [medline] AID - S0923-2508(14)00191-0 [pii] AID - 10.1016/j.resmic.2014.09.011 [doi] PST - ppublish SO - Res Microbiol. 2015 May;166(4):344-52. doi: 10.1016/j.resmic.2014.09.011. Epub 2014 Oct 7. PMID- 16680910 OWN - NLM STAT- MEDLINE DCOM- 20060606 LR - 20191210 IS - 0008-4174 (Print) IS - 0008-4174 (Linking) VI - 73 IP - 2 DP - 2006 Apr TI - Reliability and validity of the Safety Assessment Scale for people with dementia living at home. PG - 67-75 AB - BACKGROUND: With the recent funding changes in health care services, more seniors with dementia are cared for in their homes and the nature of their condition puts them at higher risk for accidents and injuries. PURPOSE: The Safety Assessment Scale (SAS) was developed for use by community healthcare providers to evaluate and lower the risk of accidents, provide recommendations to family caregivers and enhance case management. Method. The scale was assessed in terms of the reliability as well as content, criterion and construct validity with 176 community-residing people with dementia in Quebec, Alberta and British Columbia. The Safety Assessment Scale was validated in French and English. RESULTS: The SAS demonstrated an excellent test-retest (ICC=.91) and inter-rater (ICC=.88) reliability. Results for validity were also extremely good. PRACTICE IMPLICATIONS: The scale is available in French and English. The short version of the SAS is a screening tool and the longer version provides an in-depth evaluation of safety and intervention planning. The SAS can be used by a variety of health care professionals who work with individuals who have dementia. FAU - de Poulin, Courval Louise AU - de Poulin CL AD - Department of Family Medicine, McGill University, Côte-des-Neiges, Montreal. lpoulind@ssss.gouv.qc.ca FAU - Gélinas, Isabelle AU - Gélinas I FAU - Gauthier, Serge AU - Gauthier S FAU - Dayton, David AU - Dayton D FAU - Liu, Lili AU - Liu L FAU - Rossignol, Michel AU - Rossignol M FAU - Sampalis, John AU - Sampalis J FAU - Dastoor, Dolly AU - Dastoor D LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - United States TA - Can J Occup Ther JT - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie JID - 0406021 SB - IM MH - Accidents, Home/*prevention & control MH - Aged MH - Canada/epidemiology MH - Dementia/*epidemiology MH - Female MH - Humans MH - Male MH - Reproducibility of Results MH - *Safety MH - Surveys and Questionnaires EDAT- 2006/05/10 09:00 MHDA- 2006/06/07 09:00 CRDT- 2006/05/10 09:00 PHST- 2006/05/10 09:00 [pubmed] PHST- 2006/06/07 09:00 [medline] PHST- 2006/05/10 09:00 [entrez] AID - 10.1177/000841740607300201 [doi] PST - ppublish SO - Can J Occup Ther. 2006 Apr;73(2):67-75. doi: 10.1177/000841740607300201. PMID- 24227770 OWN - NLM STAT- MEDLINE DCOM- 20140428 LR - 20131114 IS - 1755-5248 (Electronic) IS - 0012-6543 (Linking) VI - 51 IP - 11 DP - 2013 Nov TI - Management of hyperemesis gravidarum. PG - 126-9 LID - 10.1136/dtb.2013.11.0215 [doi] AB - Nausea and vomiting in pregnancy are common complaints and vary considerably in duration and severity. Hyperemesis gravidarum represents the extreme end of the spectrum associated with dehydration and weight loss. As embryonic organogenesis occurs during the first trimester, pharmacological intervention for any condition during this period poses a significant clinical dilemma requiring careful assessment of risks and benefits. In the UK, there are no formal national guidelines for the management of hyperemesis gravidarum. In addition, no high-quality evidence exists for i.v. fluid and electrolyte replacement in hyperemesis gravidarum, and a Cochrane review on interventions for the treatment of nausea and vomiting in pregnancy specifically excluded studies on hyperemesis gravidarum. In this article, we review the evidence for the efficacy and safety of different management options for hyperemesis gravidarum. LA - eng PT - Journal Article PT - Review PL - England TA - Drug Ther Bull JT - Drug and therapeutics bulletin JID - 0112037 RN - 0 (Electrolytes) SB - IM MH - Electrolytes/*administration & dosage MH - Female MH - Fluid Therapy/*methods MH - Humans MH - Hyperemesis Gravidarum/complications/diagnosis/*therapy MH - Practice Guidelines as Topic MH - Pregnancy MH - Pregnancy Trimester, First EDAT- 2013/11/15 06:00 MHDA- 2014/04/29 06:00 CRDT- 2013/11/15 06:00 PHST- 2013/11/15 06:00 [entrez] PHST- 2013/11/15 06:00 [pubmed] PHST- 2014/04/29 06:00 [medline] AID - dtb.2013.11.0215 [pii] AID - 10.1136/dtb.2013.11.0215 [doi] PST - ppublish SO - Drug Ther Bull. 2013 Nov;51(11):126-9. doi: 10.1136/dtb.2013.11.0215. PMID- 24715870 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140515 LR - 20240321 IS - 1663-7976 (Print) IS - 1869-4136 (Electronic) IS - 1663-7976 (Linking) VI - 5 IP - 1 DP - 2014 Apr TI - Lumbar Lateral Interbody Fusion (LLIF): Comparative Effectiveness and Safety versus PLIF/TLIF and Predictive Factors Affecting LLIF Outcome. PG - 28-37 LID - 10.1055/s-0034-1368670 [doi] AB - STUDY DESIGN: Systematic review. STUDY RATIONALE: The surgical treatment of adult degenerative lumbar conditions remains controversial. Conventional techniques include posterior lumbar interbody fusion (PLIF) or transforaminal lumbar interbody fusion (TLIF). A new direct approach known as lumbar lateral interbody fusion (LLIF), or extreme lateral interbody fusion (XLIF(®)) or direct lateral interbody fusion (DLIF), has been introduced. Objectives The objective of this article is to determine the comparative effectiveness and safety of LLIF, at one or more levels with or without instrumentation, versus PLIF or TLIF surgery in adults with lumbar degenerative conditions, and to determine which preoperative factors affect patient outcomes following LLIF surgery. MATERIALS AND METHODS: A systematic review of the literature was performed using PubMed and bibliographies of key articles. Articles were reviewed by two independent reviewers based on predetermined inclusion and exclusion criteria. Each article was evaluated using a predefined quality rating scheme. RESULTS: The search yielded 258 citations and the following met our inclusion criteria: three retrospective cohort studies (all using historical cohorts) (class of evidence [CoE] III) examining the comparative effectiveness and safety of LLIF/XLIF(®)/DLIF versus PLIF or TLIF surgery, and one prospective cohort study (CoE II) and two retrospective cohort studies (CoE III) assessing factors affecting patient outcome following LLIF. Patients in the LLIF group experienced less estimated blood loss and a lower mortality risk compared with the PLIF group. The number of levels treated and the preoperative diagnosis were significant predictors of perioperative or early complications in two studies. CONCLUSION: There is insufficient evidence of the comparative effectiveness of LLIF versus PLIF/TLIF surgery. There is low-quality evidence suggesting that LLIF surgery results in fewer complications or reoperations than PLIF/TLIF surgery. And there is insufficient evidence that any preoperative factors exist that predict patient outcome after LLIF surgery. FAU - Barbagallo, Giuseppe M V AU - Barbagallo GM AD - Division of Neurosurgery, Department of Neurosciences, Policlinico University Hospital, Catania, Italy. FAU - Albanese, Vincenzo AU - Albanese V AD - Division of Neurosurgery, Department of Neurosciences, Policlinico University Hospital, Catania, Italy. FAU - Raich, Annie L AU - Raich AL AD - Spectrum Research, Inc., Tacoma, Washington, United States. FAU - Dettori, Joseph R AU - Dettori JR AD - Spectrum Research, Inc., Tacoma, Washington, United States. FAU - Sherry, Ned AU - Sherry N AD - Spectrum Research, Inc., Tacoma, Washington, United States. FAU - Balsano, Massimo AU - Balsano M AD - Regional Spinal Department, Alto Vicentino, OC Santorso, Vicenza, Italy. LA - eng PT - Journal Article PL - Germany TA - Evid Based Spine Care J JT - Evidence-based spine-care journal JID - 101546672 PMC - PMC3969425 OTO - NOTNLM OT - DLIF OT - LLIF OT - PLIF OT - TLIF OT - XLIF® OT - direct lateral interbody fusion OT - extreme lateral interbody fusion OT - minimally invasive COIS- Disclosures Analytic support for this work was provided by Spectrum Research, Inc. with funding from AOSpine. EDAT- 2014/04/10 06:00 MHDA- 2014/04/10 06:01 PMCR- 2015/04/01 CRDT- 2014/04/10 06:00 PHST- 2013/09/03 00:00 [received] PHST- 2013/12/17 00:00 [accepted] PHST- 2014/04/10 06:00 [entrez] PHST- 2014/04/10 06:00 [pubmed] PHST- 2014/04/10 06:01 [medline] PHST- 2015/04/01 00:00 [pmc-release] AID - 1300031sr [pii] AID - 10.1055/s-0034-1368670 [doi] PST - ppublish SO - Evid Based Spine Care J. 2014 Apr;5(1):28-37. doi: 10.1055/s-0034-1368670. PMID- 38754318 OWN - NLM STAT- MEDLINE DCOM- 20240601 LR - 20240601 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 203 DP - 2024 Aug TI - Pedestrian crash risk analysis using extreme value models: New insights and evidence. PG - 107633 LID - S0001-4575(24)00178-7 [pii] LID - 10.1016/j.aap.2024.107633 [doi] AB - Facilitating proactive pedestrian safety management, the application of extreme value theory (EVT) models has gained popularity due to its extrapolation capabilities of estimating crashes from their precursors (i.e., conflicts). However, past studies either applied EVT models for crash risk analysis of autonomous vehicle-pedestrian interactions or human-driven vehicle-pedestrian interactions at signalised intersections. However, our understanding of human-driven vehicle-pedestrian interactions remains elusive because of scant evidence of (i) EVT models' application for heterogeneous traffic conditions, (ii) appropriate set of determinants, (iii) which EVT approach to be used, and (iv) which conflict measure is appropriate. Addressing these issues, the objective of this study is to investigate pedestrian crash risk analysis in heterogeneous and disordered traffic conditions, where drivers do not follow lane disciplines. Eleven-hour video recording was collected from a busy pedestrian crossing at a midblock location in India and processed using artificial intelligence techniques. Vehicle-pedestrian interactions are characterised by two conflict measures (i.e., post encroachment time and gap time) and modelled using block maxima and peak over threshold approaches. To handle the non-stationarity of pedestrian conflict extremes, several explanatory variables are included in the models, which are estimated using the maximum likelihood estimation procedure. Modelling results indicate that the EVT models provide reasonable estimates of historical crash records at the study location. From the EVT models, a few key insights related to vehicle-pedestrian interactions are as follows. Firstly, a comparison of EVT models shows that the peak over threshold model outperforms the block maxima model. Secondly, post encroachment time conflict measure is found to be appropriate for modelling vehicle-pedestrian interactions compared to gap time. Thirdly, pedestrian crash risk significantly increases when they interact with two-wheelers in contrast with interactions involving buses where the crash risk decreases. Fourthly, pedestrian crash risk decreases when they cross in groups compared to crossing individually. Finally, pedestrian crash risk is positively related to average vehicle speed, pedestrian speed, and five-minute post encroachment time counts less than 1.5 s. Further, different block sizes are tested for the block maxima model, and the five-minute block size yields the most accurate and precise pedestrian crash estimates. These findings demonstrate the applicability of extreme value analysis for heterogeneous and disordered traffic conditions, thereby facilitating proactive safety management in disordered and undisciplined lane conditions. CI - Copyright © 2024 Elsevier Ltd. All rights reserved. FAU - Ankunda, Ampereza AU - Ankunda A AD - School of Civil Engineering, KIIT University, Bhubaneswar, Odisha 751024, India. Electronic address: 2154019@kiit.ac.in. FAU - Ali, Yasir AU - Ali Y AD - School of Architecture, Building, and Civil Engineering, Loughborough University, Leicestershire LE11 3TU, United Kingdom. Electronic address: y.y.ali@lboro.ac.uk. FAU - Mohanty, Malaya AU - Mohanty M AD - School of Civil Engineering, KIIT University, Bhubaneswar, Odisha 751024, India. Electronic address: malaya.mohantyfce@kiit.ac.in. LA - eng PT - Journal Article DEP - 20240515 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - *Accidents, Traffic/statistics & numerical data/prevention & control MH - Humans MH - *Pedestrians/statistics & numerical data MH - Risk Assessment/methods MH - India MH - Video Recording MH - Models, Theoretical MH - Artificial Intelligence MH - Likelihood Functions MH - Environment Design OTO - NOTNLM OT - Extreme value theory OT - Heterogeneous conditions OT - Pedestrian safety OT - Peer effect OT - Vehicle class COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/05/17 00:43 MHDA- 2024/06/02 00:43 CRDT- 2024/05/16 18:11 PHST- 2024/01/19 00:00 [received] PHST- 2024/05/03 00:00 [revised] PHST- 2024/05/08 00:00 [accepted] PHST- 2024/06/02 00:43 [medline] PHST- 2024/05/17 00:43 [pubmed] PHST- 2024/05/16 18:11 [entrez] AID - S0001-4575(24)00178-7 [pii] AID - 10.1016/j.aap.2024.107633 [doi] PST - ppublish SO - Accid Anal Prev. 2024 Aug;203:107633. doi: 10.1016/j.aap.2024.107633. Epub 2024 May 15. PMID- 11174237 OWN - NLM STAT- MEDLINE DCOM- 20010315 LR - 20051117 IS - 0196-0644 (Print) IS - 0196-0644 (Linking) VI - 37 IP - 2 DP - 2001 Feb TI - Efficacy, safety, and use of snake antivenoms in the United States. PG - 181-8 AB - The mainstay of hospital treatment for venomous snakebite is antivenom. There is currently only one antivenom available in the United States for the treatment of pit viper envenomation, Antivenin (Crotalidae) Polyvalent (ACP). The general indication for the administration of antivenom is presence of progressive venom injury. Progressive injury is defined as worsening local injury (eg, swelling, ecchymosis), a clinically important coagulation abnormality, or systemic effects (eg, hypotension, altered mental status). Unfortunately, there are no prospective data available regarding the efficacy of ACP. The efficacy of a new antivenom (CroFab; FabAV) composed of purified Fab specific to indigenous snake species has been demonstrated in prospective trials. FabAV appears as effective as IgG antivenoms. However, Fab molecules have a shorter half-life than IgG molecules and may allow recurrence of venom effects, if additional doses are not administered. It has also been found that other antivenoms, including ACP, also allow recurrence of venom effects. The Fab preparation has produced fewer acute or delayed (serum sickness) allergic reactions; however, further experience is needed to confirm this observation. Evaluation of this new antivenom has led to advances in our understanding of antivenoms in terms of solubility and durability. Fab fragments enter solution quickly, thereby shortening the time to antivenom administration and are remarkably stable under extreme conditions of heat and handling. FAU - Dart, R C AU - Dart RC AD - Rocky Mountain Poison and Drug Center, Denver Health Authority, and the Department of Surgery, Medicine and Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80230, USA. rdart@rmpdc.org FAU - McNally, J AU - McNally J LA - eng PT - Journal Article PT - Review PL - United States TA - Ann Emerg Med JT - Annals of emergency medicine JID - 8002646 RN - 0 (Antivenins) RN - 0 (Immunoglobulin Fab Fragments) SB - IM MH - Animals MH - Antivenins/adverse effects/*therapeutic use MH - Disease Progression MH - Drug Stability MH - Drug Utilization MH - Humans MH - Hypersensitivity/etiology MH - Immunoglobulin Fab Fragments MH - *Safety MH - Severity of Illness Index MH - Snake Bites/classification/complications/physiopathology/*therapy MH - Solubility MH - Treatment Outcome MH - United States MH - Urticaria/etiology MH - *Viperidae RF - 42 EDAT- 2001/02/15 11:00 MHDA- 2001/03/17 10:01 CRDT- 2001/02/15 11:00 PHST- 2001/02/15 11:00 [pubmed] PHST- 2001/03/17 10:01 [medline] PHST- 2001/02/15 11:00 [entrez] AID - S0196-0644(01)65378-2 [pii] AID - 10.1067/mem.2001.113372 [doi] PST - ppublish SO - Ann Emerg Med. 2001 Feb;37(2):181-8. doi: 10.1067/mem.2001.113372. PMID- 36253397 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221021 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 12 IP - 1 DP - 2022 Oct 17 TI - Finite element analysis and optimization of tractor gearbox body under various kinds of working conditions. PG - 17386 LID - 10.1038/s41598-022-22342-6 [doi] LID - 17386 AB - As the main component of the tractor gearbox, the box has the functions of shifting operation and carrying the cab, it also carries part of the framework function. If the strength, stiffness, or vibration characteristics of the box do not meet the allowable requirements, large vibration and noise may occur, and even there is the possibility of fracture in some limiting conditions. To solve this problem, according to the structural parameters of a gearbox, the three-dimensional model of the box was established by using the three-dimensional modeling software Creo. According to the dangerous degree of the transmission load when the tractor is working normally, three vehicle working conditions are selected: a round of suspension conditions, farm tool lifting conditions, and emergency turning conditions. In addition, according to the transmission ratio of each gear meshing inside the gearbox, two gear conditions are selected: gear condition one and reverse gear condition one. The forces of the box under these extreme conditions are analyzed. The static analysis and modal analysis of the tractor gearbox are carried out by using the Static Structural module of ANSYS Workbanch. The deformation, equivalent stress distribution, and modal vibration frequency of the gearbox are tested. The topology optimization method is used to improve structural defects and reduce box quality. The results show that the weight of the optimized box reduces by 8.44%, the deformation decreased by 15.89%, and the equivalent stress decreased by 18.34%. The strength and stiffness of the box are improved, the quality is lightweight, the waste of resources is reduced, and the heat dissipation performance and fracture resistance of the box are enhanced. CI - © 2022. The Author(s). FAU - Dong, Sihui AU - Dong S AD - School of Traffic and Transportation Engineering, Dalian Jiaotong University, Dalian, 116028, China. FAU - Li, Shiqun AU - Li S AD - School of Traffic and Transportation Engineering, Dalian Jiaotong University, Dalian, 116028, China. FAU - Fu, Shenghui AU - Fu S AD - School of Mechanical and Electronic Engineering, Shandong Agricultural University, Tai'an, 271000, China. FAU - Wang, Kang AU - Wang K AUID- ORCID: 0000-0001-6941-6635 AD - School of Traffic and Transportation Engineering, Dalian Jiaotong University, Dalian, 116028, China. kliek_618@163.com. AD - College of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China. kliek_618@163.com. LA - eng PT - Journal Article DEP - 20221017 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC9576754 COIS- The authors declare no competing interests. EDAT- 2022/10/18 06:00 MHDA- 2022/10/18 06:01 PMCR- 2022/10/17 CRDT- 2022/10/17 23:19 PHST- 2022/08/22 00:00 [received] PHST- 2022/10/13 00:00 [accepted] PHST- 2022/10/17 23:19 [entrez] PHST- 2022/10/18 06:00 [pubmed] PHST- 2022/10/18 06:01 [medline] PHST- 2022/10/17 00:00 [pmc-release] AID - 10.1038/s41598-022-22342-6 [pii] AID - 22342 [pii] AID - 10.1038/s41598-022-22342-6 [doi] PST - epublish SO - Sci Rep. 2022 Oct 17;12(1):17386. doi: 10.1038/s41598-022-22342-6. PMID- 22150424 OWN - NLM STAT- MEDLINE DCOM- 20120525 LR - 20111214 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 29 Suppl 1 DP - 2011 TI - Nutrition for winter sports. PG - S127-36 LID - 10.1080/02640414.2011.574721 [doi] AB - Winter sports are played in cold conditions on ice or snow and often at moderate to high altitude. The most important nutritional challenges for winter sport athletes exposed to environmental extremes include increased energy expenditure, accelerated muscle and liver glycogen utilization, exacerbated fluid loss, and increased iron turnover. Winter sports, however, vary greatly regarding their nutritional requirements due to variable physiological and physique characteristics, energy and substrate demands, and environmental training and competition conditions. What most winter sport athletes have in common is a relatively lean physique and high-intensity training periods, thus they require greater energy and nutrient intakes, along with adequate food and fluid before, during, and after training. Event fuelling is most challenging for cross-country skiers competing in long events, ski jumpers aiming to reduce their body weight, and those winter sport athletes incurring repeated qualification rounds and heats. These athletes need to ensure carbohydrate availability throughout competition. Finally, winter sport athletes may benefit from dietary and sport supplements; however, attention should be paid to safety and efficacy if supplementation is considered. FAU - Meyer, Nanna L AU - Meyer NL AD - Beth-El College of Nursing and Health Sciences, University of Colorado, Colorado 80918, USA. nmeyer@uccs.edu FAU - Manore, Melinda M AU - Manore MM FAU - Helle, Christine AU - Helle C LA - eng PT - Journal Article DEP - 20110621 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 RN - 0 (Dietary Carbohydrates) SB - IM MH - Athletic Performance/physiology MH - *Cold Temperature MH - Diet MH - Dietary Carbohydrates/*administration & dosage MH - Dietary Supplements MH - *Energy Intake MH - Energy Metabolism MH - Exercise/*physiology MH - Humans MH - *Nutritional Requirements MH - Physical Education and Training MH - Seasons MH - Skating/*physiology MH - Skiing/physiology MH - Snow Sports/*physiology MH - Sports/*physiology MH - Stress, Physiological EDAT- 2011/12/14 06:00 MHDA- 2012/05/26 06:00 CRDT- 2011/12/14 06:00 PHST- 2011/12/14 06:00 [entrez] PHST- 2011/12/14 06:00 [pubmed] PHST- 2012/05/26 06:00 [medline] AID - 10.1080/02640414.2011.574721 [doi] PST - ppublish SO - J Sports Sci. 2011;29 Suppl 1:S127-36. doi: 10.1080/02640414.2011.574721. Epub 2011 Jun 21. PMID- 37224713 OWN - NLM STAT- MEDLINE DCOM- 20230609 LR - 20230612 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 456 DP - 2023 Aug 15 TI - Bioremediation of aniline aerofloat wastewater at extreme conditions using a novel isolate Burkholderia sp. WX-6 immobilized on biochar. PG - 131668 LID - S0304-3894(23)00951-2 [pii] LID - 10.1016/j.jhazmat.2023.131668 [doi] AB - Aniline aerofloat (AAF) is a refractory organic pollutant in floatation wastewater. Little information is currently available on its biodegradation. In this study, a novel AAF-degrading strain named Burkholderia sp. WX-6 was isolated from mining sludge. The strain could degrade more than 80% of AAF at different initial concentrations (100-1000 mg/L) within 72 h. AAF degrading curves were fitted well with the four-parameter logistic model (R(2) >0.97), with the degrading half-life ranging from 16.39 to 35.55 h. This strain harbors metabolic pathway for complete degradation of AAF and is resistant to salt, alkali, and heavy metals. Immobilization of the strain on biochar enhanced both tolerance to extreme conditions and AAF removal, with up to 88% of AAF removal rate in simulated wastewater under alkaline (pH 9.5) or heavy metal pollution condition. In addition, the biochar-immobilized bacteria removed 59.4% of COD in the wastewater containing AAF and mixed metal ions within 144 h, significantly (P < 0.05) higher than those by free bacteria (42.6%) and biochar (48.2%) only. This work is helpful to understand AAF biodegradation mechanism and provides viable references for developing practical biotreatment technique of mining wastewater. CI - Copyright © 2023 Elsevier B.V. All rights reserved. FAU - Ye, Jin-Cheng AU - Ye JC AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Zhao, Qiu-Shi AU - Zhao QS AD - School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Liang, Jin-Wei AU - Liang JW AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Wang, Xiao-Xiao AU - Wang XX AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Zhan, Zhen-Xuan AU - Zhan ZX AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Du, Huan AU - Du H AD - Guangzhou Customs Technology Center, Guangzhou 510632, China. FAU - Cheng, Ji-Liang AU - Cheng JL AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Xiang, Lei AU - Xiang L AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Feng, Nai-Xian AU - Feng NX AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Liu, Bai-Lin AU - Liu BL AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Li, Yan-Wen AU - Li YW AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Li, Hui AU - Li H AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Cai, Quan-Ying AU - Cai QY AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. FAU - Zhao, Hai-Ming AU - Zhao HM AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, Guangzhou 510642, China. Electronic address: zhaohm99@jnu.edu.cn. FAU - Mo, Ce-Hui AU - Mo CH AD - Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: tchmo@jnu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230519 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Wastewater) RN - 0 (biochar) RN - 16291-96-6 (Charcoal) RN - SIR7XX2F1K (aniline) RN - 0 (Aniline Compounds) SB - IM MH - *Wastewater MH - Biodegradation, Environmental MH - *Charcoal MH - Aniline Compounds OTO - NOTNLM OT - Aniline aerofloat OT - Biochar-immobilization OT - Burkholderia sp. OT - Flotation wastewater OT - Water bioremediation COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reports in this paper. EDAT- 2023/05/25 01:07 MHDA- 2023/06/09 06:42 CRDT- 2023/05/24 18:06 PHST- 2023/03/01 00:00 [received] PHST- 2023/05/17 00:00 [revised] PHST- 2023/05/19 00:00 [accepted] PHST- 2023/06/09 06:42 [medline] PHST- 2023/05/25 01:07 [pubmed] PHST- 2023/05/24 18:06 [entrez] AID - S0304-3894(23)00951-2 [pii] AID - 10.1016/j.jhazmat.2023.131668 [doi] PST - ppublish SO - J Hazard Mater. 2023 Aug 15;456:131668. doi: 10.1016/j.jhazmat.2023.131668. Epub 2023 May 19. PMID- 26340730 OWN - NLM STAT- MEDLINE DCOM- 20160708 LR - 20150905 IS - 1536-3724 (Electronic) IS - 1050-642X (Linking) VI - 25 IP - 5 DP - 2015 Sep TI - General Consideration in the History, Physical Examination, and Safety Determination. PG - 392-5 LID - 10.1097/JSM.0000000000000230 [doi] AB - A thorough medical history is perhaps the most important aspect when evaluating an athlete before wilderness adventure. A physical examination should follow focusing on conditions that may be affected by changes in atmospheric pressure, extremes of temperature, or altitude. This information can then be used to make safety recommendations ensuring that adventurers are able to safely enjoy participation in the wilderness pursuit of their choice. FAU - Buchanan, Jonathan AU - Buchanan J AD - *Legacy Medical Group, Sports Medicine, Beaverton, Oregon; †Maine Medical Center, Portland, Maine; ‡University of Utah, Salt Lake City, Utah; and §Texas Tech University, Lubbock, Texas. FAU - Dexter, William AU - Dexter W FAU - Powell, Amy AU - Powell A FAU - Wright, Justin AU - Wright J LA - eng PT - Journal Article PT - Review PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM MH - Athletes MH - Humans MH - Physical Examination/*methods MH - Risk Assessment MH - *Safety MH - *Sports MH - *Wilderness Medicine EDAT- 2015/09/05 06:00 MHDA- 2016/07/09 06:00 CRDT- 2015/09/05 06:00 PHST- 2015/09/05 06:00 [entrez] PHST- 2015/09/05 06:00 [pubmed] PHST- 2016/07/09 06:00 [medline] AID - 00042752-201509000-00004 [pii] AID - 10.1097/JSM.0000000000000230 [doi] PST - ppublish SO - Clin J Sport Med. 2015 Sep;25(5):392-5. doi: 10.1097/JSM.0000000000000230. PMID- 34398905 OWN - NLM STAT- MEDLINE DCOM- 20211209 LR - 20211214 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 16 IP - 8 DP - 2021 TI - Modelling speed behaviour in rural highways: Safety analysis of driving under adverse road-weather conditions. PG - e0256322 LID - 10.1371/journal.pone.0256322 [doi] LID - e0256322 AB - This study proposes a methodical approach to model desired speed distributions under different road-weather and traffic conditions followed by identification of road-weather conditions with potentially higher safety risks in rural divided highways located in extremely cold regions. Desired speed distributions encompassing unique combinations of adverse road-weather and traffic conditions are modelled as normal distributions characterized by their means and standard deviations formulated based on two principal statistical theorems and techniques i.e., Central Limit Theorem and Minimum Variance Unbiased Estimation. Combination of the precipitation conditions, road surface conditions, time of the day, temperature, traffic flow and the heavy vehicle percentage at the time of travel were considered in defining the combinations of road-weather and traffic conditions. The findings reveal that simultaneous occurrence of particular precipitation and pavement conditions significantly affect the characteristics of the desired speed distribution and potentially expose drivers to elevated safety risks. Jurisdictions experiencing extreme road-weather conditions may adapt the proposed methodology to assess speed behaviour under different road-weather conditions to establishing and deploying weather-responsive traffic management strategies such as variable speed limit to regulate speeding and improve traffic safety in winter. FAU - Yasanthi, Rillagoda G N AU - Yasanthi RGN AD - Department of Civil Engineering, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Mehran, Babak AU - Mehran B AUID- ORCID: 0000-0003-4440-3226 AD - Department of Civil Engineering, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Alhajyaseen, Wael K M AU - Alhajyaseen WKM AUID- ORCID: 0000-0003-1757-1363 AD - Qatar Transportation and Traffic Safety Center, Qatar University, Doha, Qatar. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210816 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Accidents, Traffic/*prevention & control MH - *Automobile Driving MH - *High Fidelity Simulation Training MH - Humans MH - Manitoba MH - Risk Assessment/statistics & numerical data MH - Rural Population MH - Seasons MH - Weather PMC - PMC8367011 COIS- The authors have declared that no competing interests exist. EDAT- 2021/08/17 06:00 MHDA- 2021/12/15 06:00 PMCR- 2021/08/16 CRDT- 2021/08/16 17:19 PHST- 2021/05/22 00:00 [received] PHST- 2021/08/03 00:00 [accepted] PHST- 2021/08/16 17:19 [entrez] PHST- 2021/08/17 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] PHST- 2021/08/16 00:00 [pmc-release] AID - PONE-D-21-16916 [pii] AID - 10.1371/journal.pone.0256322 [doi] PST - epublish SO - PLoS One. 2021 Aug 16;16(8):e0256322. doi: 10.1371/journal.pone.0256322. eCollection 2021. PMID- 32105559 OWN - NLM STAT- MEDLINE DCOM- 20210212 LR - 20210212 IS - 1545-9632 (Electronic) IS - 1545-9624 (Linking) VI - 17 IP - 4 DP - 2020 Apr TI - Comparison between OSHA-NIOSH Heat Safety Tool app and WBGT monitor to assess heat stress risk in agriculture. PG - 181-192 LID - 10.1080/15459624.2020.1721512 [doi] AB - Agricultural workers are exposed to heat stress due to spending significant amount of time outdoors. Risk information from mobile apps is more readily available for timely advice on risk management that is crucial in preventing severe acute illnesses and deaths, but its reliability is unknown. The purpose of this study was to determine the reliability of the OSHA-NIOSH Heat Safety Tool mobile app in providing accurate risk information to prevent heat-related illnesses among agricultural workers in eastern North Carolina. Wet bulb globe temperature (WBGT) indices were datalogged at two agricultural sites using heat stress monitors from April-August 2019 and were assigned to risk levels (minimal, low, moderate, high, extreme) by workload (light, moderate, heavy, very heavy) based on the ACGIH(®) Threshold Limit Values (TLVs(®)). Hourly heat index (HI) and its corresponding risk level were obtained using the app. Hourly HI-based risk level assignments were time-matched to their corresponding WBGT-based risk level assignments (682 pairs) and analyzed using cross-tabulation by determining the percentage of hourly WBGT-based risk level assignments ("gold standard") with the same hourly HI-based risk level assignments under different workloads, with a higher percentage indicating higher app reliability. Results showed that the app correctly identified 60-100% of minimal risk conditions, depending on workload type, but its reliability decreased as the heat stress risk condition and workload became more severe. The app identified the majority of low risk conditions for a moderate workload (74%) and moderate risk conditions for a light workload (94%) only, indicating limited use in these specific conditions, while the app identified 0% of either the high risk or extreme risk conditions at any workload type. It is concluded that the performance of the OSHA-NIOSH app in assessing occupational risk to heat stress is not protective of workers particularly for heavy and very heavy workloads, and that the use of the app for the assessment of occupational heat stress risk in agricultural settings is not recommended. FAU - Dillane, Danielle AU - Dillane D AD - Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, North Carolina. FAU - Balanay, Jo Anne G AU - Balanay JAG AD - Environmental Health Sciences Program, Department of Health Education and Promotion, East Carolina University, Greenville, North Carolina. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20200227 PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - Agricultural Workers' Diseases/*prevention & control MH - Agriculture/*standards MH - Heat Stress Disorders/*prevention & control MH - Hot Temperature/adverse effects MH - Humans MH - *Mobile Applications MH - National Institute for Occupational Safety and Health, U.S./*standards MH - Occupational Health/*standards MH - Risk Assessment MH - United States MH - United States Occupational Safety and Health Administration/*standards OTO - NOTNLM OT - Agriculture OT - WGBT OT - heat index OT - occupational exposure OT - outdoor workers OT - risk assessment EDAT- 2020/02/28 06:00 MHDA- 2021/02/13 06:00 CRDT- 2020/02/28 06:00 PHST- 2020/02/28 06:00 [pubmed] PHST- 2021/02/13 06:00 [medline] PHST- 2020/02/28 06:00 [entrez] AID - 10.1080/15459624.2020.1721512 [doi] PST - ppublish SO - J Occup Environ Hyg. 2020 Apr;17(4):181-192. doi: 10.1080/15459624.2020.1721512. Epub 2020 Feb 27. PMID- 24129319 OWN - NLM STAT- MEDLINE DCOM- 20140724 LR - 20131202 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 62 DP - 2014 Jan TI - Freeway safety estimation using extreme value theory approaches: a comparative study. PG - 32-41 LID - S0001-4575(13)00359-X [pii] LID - 10.1016/j.aap.2013.09.006 [doi] AB - The validity of traffic conflicts and other surrogate events has been a great concern in the development and application of surrogate safety measures. Extreme value theory (EVT) offers a strong modeling framework for linking surrogate measures of safety to crash frequency. This study aims at developing, validating, and comparing two EVT modeling approaches for characterizing extreme events. The two alternative EVT approaches, block maxima (BM) and peak over threshold (POT), are used to relate surrogates and lane change maneuver-related crashes on freeways. The surrogate measure is post encroachment times measured from 4189 lane change maneuvers recorded at 29 directional freeway segments with approximately 3-h observation for each segment. The sample size, serial dependency, and non-stationarity issues for both approaches are examined. The comparison of results from the two modeling approaches indicates that the POT approach performs better than BM approach from the aspects of data utilization, estimate accuracy and estimate reliability. This conclusion is drawn on condition of relatively short time observations. An additional comparison is conducted between the estimated crashes and estimated return levels from two approaches. Due to large variances in the estimated crashes, much more robust estimated return levels are recommended for freeway safety evaluation. CI - Copyright © 2013 Elsevier Ltd. All rights reserved. FAU - Zheng, Lai AU - Zheng L AD - School of Transportation Science and Engineering, Harbin Institute of Technology, China; Department of Civil and Environmental Engineering, Carleton University, Canada. Electronic address: zhenglai@hit.edu.cn. FAU - Ismail, Karim AU - Ismail K FAU - Meng, Xianghai AU - Meng X LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130913 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*statistics & numerical data MH - Automobile Driving/*statistics & numerical data MH - *Environment Design MH - Humans MH - Models, Statistical MH - Reproducibility of Results MH - *Safety OTO - NOTNLM OT - Block maxima OT - Extreme value theory OT - Freeway safety OT - Peak over threshold EDAT- 2013/10/17 06:00 MHDA- 2014/07/25 06:00 CRDT- 2013/10/17 06:00 PHST- 2013/05/17 00:00 [received] PHST- 2013/08/20 00:00 [revised] PHST- 2013/09/01 00:00 [accepted] PHST- 2013/10/17 06:00 [entrez] PHST- 2013/10/17 06:00 [pubmed] PHST- 2014/07/25 06:00 [medline] AID - S0001-4575(13)00359-X [pii] AID - 10.1016/j.aap.2013.09.006 [doi] PST - ppublish SO - Accid Anal Prev. 2014 Jan;62:32-41. doi: 10.1016/j.aap.2013.09.006. Epub 2013 Sep 13. PMID- 9799014 OWN - NLM STAT- MEDLINE DCOM- 19981229 LR - 20191102 IS - 1090-3127 (Print) IS - 1090-3127 (Linking) VI - 2 IP - 4 DP - 1998 Oct-Dec TI - Continuous core temperature monitoring of search and rescue divers during extreme conditions. PG - 280-4 AB - OBJECTIVES: To study the feasibility of continuously monitoring core temperatures of search and rescue divers, to compare core temperature gradients occurring during warm and cold diving events, and to identify conditions under which divers are subjected to extreme temperatures. METHODS: Between June 1994 and March 1995, emergency medical technicians (EMTs) from two midwestern dive teams volunteered to ingest an encapsulated temperature sensor developed for the National Aeronautics and Space Administration. The capsule monitored continuous core temperatures and transmitted the data to a recorder worn under the divers' dry suits. RESULTS: Twenty male EMTs, mean age 34 years and mean body weight 184 pounds, were monitored during training. Nine dives were ice dives, with ice thickness averaging 9 inches, and mean ambient temperatures of 33 degrees F. Eleven dives were warm-water dives; average water temperature was 70 degrees F and mean ambient temperature was 74 degrees F. The average time spent in the dry suit was 95 minutes, and the mean total bottom time was 15 minutes. The ice divers showed a mean increase in core temperature of 1.0 degrees C, while the warm-water divers showed a mean increase of 1.2 degrees C. Divers experiencing the most extreme fluctuations were those in the role of safety diver, regardless of the season. Divers reported more subjective discomfort during ice dives than during warm-water dives. CONCLUSIONS: Continuous monitoring of body temperature during the duration of dive operations is possible, but labor-intensive. Safety measures to protect divers from extreme core temperature fluctuations should focus on the safety diver as well as the active diver. FAU - White, L J AU - White LJ AD - Emergency Medicine Residency Program, Akron General Medical Center, Ohio 44307, USA. lwhite@agmc.org FAU - Jackson, F AU - Jackson F FAU - McMullen, M J AU - McMullen MJ FAU - Lystad, J AU - Lystad J FAU - Jones, J S AU - Jones JS FAU - Hubers, R H AU - Hubers RH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Prehosp Emerg Care JT - Prehospital emergency care JID - 9703530 RN - 0 (Capsules) SB - IM CIN - Prehosp Emerg Care. 1998 Oct-Dec;2(4):330-3. doi: 10.1080/10903129808958891. PMID: 9799025 MH - Adult MH - *Body Temperature MH - Capsules MH - Diving/*injuries MH - *Emergency Medical Technicians MH - Feasibility Studies MH - Heat Stress Disorders/*diagnosis/etiology MH - Humans MH - Hypothermia/*diagnosis/etiology MH - Male MH - Monitoring, Physiologic/instrumentation/*methods MH - Occupational Diseases/*diagnosis/etiology MH - Prospective Studies MH - Protective Clothing MH - *Rescue Work MH - Time Factors EDAT- 1998/11/03 00:00 MHDA- 1998/11/03 00:01 CRDT- 1998/11/03 00:00 PHST- 1998/11/03 00:00 [pubmed] PHST- 1998/11/03 00:01 [medline] PHST- 1998/11/03 00:00 [entrez] AID - 10.1080/10903129808958880 [doi] PST - ppublish SO - Prehosp Emerg Care. 1998 Oct-Dec;2(4):280-4. doi: 10.1080/10903129808958880. PMID- 22723411 OWN - NLM STAT- MEDLINE DCOM- 20120720 LR - 20240412 IS - 1095-9203 (Electronic) IS - 0036-8075 (Print) IS - 0036-8075 (Linking) VI - 336 IP - 6088 DP - 2012 Jun 22 TI - Evolution, safety, and highly pathogenic influenza viruses. PG - 1529-31 LID - 10.1126/science.1223204 [doi] AB - Experience with influenza has shown that predictions of virus phenotype or fitness from nucleotide sequence are imperfect and that predicting the timing and course of evolution is extremely difficult. Such uncertainty means that the risk of experiments with mammalian-transmissible, possibly highly virulent influenza viruses remains high even if some aspects of their laboratory biology are reassuring; it also implies limitations on the ability of laboratory observations to guide interpretation of surveillance of strains in the field. Thus, we propose that future experiments with virulent pathogens whose accidental or deliberate release could lead to extensive spread in human populations should be limited by explicit risk-benefit considerations. FAU - Lipsitch, Marc AU - Lipsitch M AD - Center for Communicable Disease Dynamics and Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. mlipsitc@hsph.harvard.edu FAU - Plotkin, Joshua B AU - Plotkin JB FAU - Simonsen, Lone AU - Simonsen L FAU - Bloom, Barry AU - Bloom B LA - eng GR - U54 GM088558/GM/NIGMS NIH HHS/United States GR - U54GM088558/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Science JT - Science (New York, N.Y.) JID - 0404511 RN - 0 (Antigens, Viral) RN - 0 (Antiviral Agents) SB - IM MH - Animals MH - Antigenic Variation MH - Antigens, Viral MH - Antiviral Agents/pharmacology/therapeutic use MH - Biohazard Release MH - *Containment of Biohazards MH - Drug Resistance, Viral MH - *Evolution, Molecular MH - Ferrets MH - Humans MH - Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity MH - Influenza A virus/drug effects/genetics/immunology/*pathogenicity MH - Influenza, Human/drug therapy/transmission/*virology MH - Laboratory Infection/epidemiology MH - Mutation MH - Orthomyxoviridae Infections/transmission/*virology MH - Public Policy MH - Risk Assessment MH - *Safety MH - Security Measures MH - United States/epidemiology PMC - PMC3467308 MID - NIHMS404677 EDAT- 2012/06/23 06:00 MHDA- 2012/07/21 06:00 PMCR- 2012/12/22 CRDT- 2012/06/23 06:00 PHST- 2012/06/23 06:00 [entrez] PHST- 2012/06/23 06:00 [pubmed] PHST- 2012/07/21 06:00 [medline] PHST- 2012/12/22 00:00 [pmc-release] AID - 336/6088/1529 [pii] AID - 10.1126/science.1223204 [doi] PST - ppublish SO - Science. 2012 Jun 22;336(6088):1529-31. doi: 10.1126/science.1223204. PMID- 540621 OWN - NLM STAT- MEDLINE DCOM- 19800625 LR - 20181113 IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 33 DP - 1979 Dec TI - Occupational safety and health implications of increased coal utilization. PG - 285-302 AB - An area of major concern in considering increased coal production and utilization is the health and safety of increased numbers of workers who mine, process, or utilize coal. Hazards related to mining activities in the past have been especially serious, resulting in many mine related accidental deaths, disabling injuries, and disability and death from chronic lung disease. Underground coal mines are clearly less safe than surface mines. Over one-third of currently employed underground miners experience chronic lung disease. Other stresses include noise and extremes of heat and cold. Newly emphasized technologies of the use of diesel powered mining equipment and the use of longwall mining techniques may be associated with serious health effects. Workers at coal-fired power plants are also potentially at risk of occupational diseases. Occupational safety and health aspects of coal mining are understood well enough today to justify implementing necessary and technically feasible and available control measures to minimize potential problems associated with increased coal production and use in the future. Increased emphasis on safety and health training for inexperienced coal miners expected to enter the work force is clearly needed. The recently enacted Federal Mine Safety and Health Act of 1977 will provide impetus for increased control over hazards in coal mining. FAU - Bridbord, K AU - Bridbord K FAU - Costello, J AU - Costello J FAU - Gamble, J AU - Gamble J FAU - Groce, D AU - Groce D FAU - Hutchison, M AU - Hutchison M FAU - Jones, W AU - Jones W FAU - Merchant, J AU - Merchant J FAU - Ortmeyer, C AU - Ortmeyer C FAU - Reger, R AU - Reger R FAU - Wagner, W L AU - Wagner WL LA - eng PT - Journal Article PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 RN - 0 (Coal) SB - IM MH - Anthracosilicosis/etiology MH - Coal/*analysis MH - *Environmental Exposure MH - Forecasting MH - Humans MH - Mortality MH - Occupational Diseases/etiology MH - Pneumoconiosis/etiology PMC - PMC1638124 EDAT- 1979/12/01 00:00 MHDA- 1979/12/01 00:01 PMCR- 1979/12/01 CRDT- 1979/12/01 00:00 PHST- 1979/12/01 00:00 [pubmed] PHST- 1979/12/01 00:01 [medline] PHST- 1979/12/01 00:00 [entrez] PHST- 1979/12/01 00:00 [pmc-release] AID - 10.1289/ehp.7933285 [doi] PST - ppublish SO - Environ Health Perspect. 1979 Dec;33:285-302. doi: 10.1289/ehp.7933285. PMID- 35270446 OWN - NLM STAT- MEDLINE DCOM- 20220413 LR - 20240824 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 19 IP - 5 DP - 2022 Feb 27 TI - The Ecological Dynamics Framework: An Innovative Approach to Performance in Extreme Environments: A Narrative Review. LID - 10.3390/ijerph19052753 [doi] LID - 2753 AB - (1) Background: Uncertainty in extreme sports performance environments, such as climbing, provides considerable psycho-emotional and physiological demands, notably due to the many different environments in which climbing can be performed. This variety of environments, conditions of practice and engagement would challenge the acquisition of perceptual-motor skills; (2) Methods: To better understand how perceptual-motor skills are controlled and acquired in climbing, we proposed a narrative review anchored in the ecological dynamics theoretical framework and showed how this theoretical framework would support a nonlinear pedagogy to skill acquisition and to design safe learning and training situations that are representative of extreme performance contexts; (3) Results: We explained three theoretical pillars and we provide examples for design intervention following nonlinear pedagogy, notably (i) to set a constraint-led approach (in particular task constraint), (ii) to implement conditions of practice (constant vs. variable, imposed vs. self-controlled), (iii) to promote adaptive and creative behavioral variability during practice; (4) Conclusions: The challenge for the extreme sport practitioner is how to set up conditions of practice for efficient exploration in a manner that manages the dangers of performing in uncertain environments. Representing uncertainty within the relative safety of indoor settings may be one approach for preparing climbers for performance in extreme environments. FAU - Seifert, Ludovic AU - Seifert L AD - Faculty of Sport Sciences, University of Rouen Normandy, CETAPS EA3832, 76821 Mont Saint Aignan, France. AD - Institut Universitaire de France (IUF), 75231 Paris, France. FAU - Hacques, Guillaume AU - Hacques G AUID- ORCID: 0000-0002-9760-6556 AD - Faculty of Sport Sciences, University of Rouen Normandy, CETAPS EA3832, 76821 Mont Saint Aignan, France. FAU - Komar, John AU - Komar J AUID- ORCID: 0000-0002-2063-4065 AD - Physical Education and Sport Sciences, National Institute of Education, Nangyang University of Singapore, Singapore 637616, Singapore. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20220227 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - *Athletic Performance/physiology MH - Extreme Environments MH - Learning MH - *Motor Skills/physiology PMC - PMC8910696 OTO - NOTNLM OT - climbing OT - complex system OT - motor control and learning OT - movement variability OT - perception–action coupling COIS- The authors declare no conflict of interest. EDAT- 2022/03/11 06:00 MHDA- 2022/04/14 06:00 PMCR- 2022/02/27 CRDT- 2022/03/10 15:39 PHST- 2021/12/17 00:00 [received] PHST- 2022/02/21 00:00 [revised] PHST- 2022/02/23 00:00 [accepted] PHST- 2022/03/10 15:39 [entrez] PHST- 2022/03/11 06:00 [pubmed] PHST- 2022/04/14 06:00 [medline] PHST- 2022/02/27 00:00 [pmc-release] AID - ijerph19052753 [pii] AID - ijerph-19-02753 [pii] AID - 10.3390/ijerph19052753 [doi] PST - epublish SO - Int J Environ Res Public Health. 2022 Feb 27;19(5):2753. doi: 10.3390/ijerph19052753. PMID- 35589309 OWN - NLM STAT- MEDLINE DCOM- 20220523 LR - 20220612 IS - 1879-1247 (Electronic) IS - 0022-4375 (Linking) VI - 81 DP - 2022 Jun TI - Adjustment of key lane change parameters to develop microsimulation models for representative assessment of safety and operational impacts of adverse weather using SHRP2 naturalistic driving data. PG - 9-20 LID - S0022-4375(22)00002-0 [pii] LID - 10.1016/j.jsr.2022.01.002 [doi] AB - INTRODUCTION: Adverse weather has a considerable negative impact on safety and mobility of transportation networks. Microsimulation models are one of the potential tools that could be used to evaluate the safety and operational impacts of adverse weather. The development of a realistic microsimulation model requires the adjustment of driving behavior parameters with disaggregate trajectory-level data. This study presented a novel approach to update and adjust lane change model parameters for the development of realistic microsimulation models in different weather conditions by leveraging the trajectory-level data from SHRP2 Naturalistic Driving Study (NDS). METHOD: Representative key lane change parameters in various weather conditions were extracted from an automatic identification algorithm. These lane change parameters were used to develop microsimulation models in VISSIM in an attempt to assess the safety and operational impacts of adverse weather on a freeway weaving segment. RESULTS: The evaluation of safety impacts of adverse weather with regard to three Surrogate Measures of Safety (SMoS) namely Time-to-Collision (TTC), Post Encroachment Time (PET), and Deceleration Rate to Avoid Collision (DRAC) suggested that extreme adverse weather (including heavy rain, heavy snow, and heavy fog) produced a higher total number of simulated conflicts compared to clear weather. The operational analysis results revealed that adjusted parameters in most of the adverse weather produced lower average speeds with higher total travel times and total delays than clear weather. CONCLUSIONS: The outcomes of safety and operational assessments for the adjusted parameters showed that the development of microsimulation models should be based on weather-specific, rather than default parameters. PRACTICAL APPLICATIONS: The methodology presented in this study could be adopted by transportation agencies to develop weather-specific microsimulation models. Moreover, the demonstrated approach could be used to evaluate different Connected Vehicle (CV) applications related to lane change in terms of safety and operations in microsimulation platforms. CI - Copyright © 2022 National Safety Council and Elsevier Ltd. All rights reserved. FAU - Das, Anik AU - Das A AD - University of Wyoming, Department of Civil & Architectural Engineering & Construction Management, 1000 E University Ave, Dept. 3295, Laramie, WY 82071, United States. Electronic address: adas4@uwyo.edu. FAU - Ahmed, Mohamed M AU - Ahmed MM AD - University of Wyoming, Department of Civil & Architectural Engineering & Construction Management, 1000 E University Ave, Dept. 3295, Laramie, WY 82071, United States. Electronic address: mahmed@uwyo.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220201 PL - United States TA - J Safety Res JT - Journal of safety research JID - 1264241 SB - IM MH - *Accidents, Traffic MH - Algorithms MH - *Automobile Driving MH - Humans MH - Safety MH - Weather OTO - NOTNLM OT - Adverse weather OT - Lane change behavior OT - Microsimulation model OT - Naturalistic Driving Study OT - VISSIM COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/05/20 06:00 MHDA- 2022/05/24 06:00 CRDT- 2022/05/19 21:05 PHST- 2021/03/29 00:00 [received] PHST- 2021/08/18 00:00 [revised] PHST- 2022/01/19 00:00 [accepted] PHST- 2022/05/19 21:05 [entrez] PHST- 2022/05/20 06:00 [pubmed] PHST- 2022/05/24 06:00 [medline] AID - S0022-4375(22)00002-0 [pii] AID - 10.1016/j.jsr.2022.01.002 [doi] PST - ppublish SO - J Safety Res. 2022 Jun;81:9-20. doi: 10.1016/j.jsr.2022.01.002. Epub 2022 Feb 1. PMID- 29462053 OWN - NLM STAT- MEDLINE DCOM- 20190219 LR - 20190320 IS - 1473-5695 (Electronic) IS - 0969-9546 (Linking) VI - 25 IP - 6 DP - 2018 Dec TI - Vitamin K antagonists and emergencies. PG - 378-386 LID - 10.1097/MEJ.0000000000000541 [doi] AB - The recent emergence of 'non-VKA' oral anticoagulants may have led to some forgetting that vitamin K antagonists (VKA) are by far the most widely prescribed oral anticoagulants worldwide. Consequently, we decided to summarize the information available on them. This paper presents the problems facing emergency physicians confronted with patients on VKAs in 10 points, from pharmacological data to emergency management. Vitamin K antagonists remain preferable in many situations including in the elderly, in patients with extreme body weights, severe chronic kidney or liver disease or valvular heart disease, and in patients taking VKAs with well-controlled international normalized ratios (INRs). Given the way VKAs work, a stable anticoagulant state can only be achieved at the earliest 5 days after starting therapy. The induction phase of VKA treatment is associated with the highest risk of bleeding; validated algorithms based on INR values have to be followed. VKA asymptomatic overdoses and 'non-severe' hemorrhage are managed by omitting a dose or stopping treatment plus administering vitamin K depending on the INR. Major bleeding is managed using a VKA reversal strategy. A prothrombin complex concentrate infusion plus vitamin K is preferred to rapidly achieve an INR of up to 1.5 and maintain a normal coagulation profile. The INR must be measured 30 min after the infusion. Before an invasive procedure, if an INR of less than 1.5 (<1.3 in neurosurgery) is required, it can be achieved by combining prothrombin complex concentrate and vitamin K. A well-codified strategy is essential for managing patients requiring emergency invasive procedures or presenting bleeding complications. FAU - Lapostolle, Frédéric AU - Lapostolle F AD - SAMU 93, UF Recherche-Enseignement-Qualité, Université Paris 13, Inserm U942, Hôpital Avicenne, Bobigny. FAU - Siguret, Virginie AU - Siguret V AD - INSERM UMR-S1140, Université Paris Descartes, Sorbonne Paris Cité. AD - Service d'hématologie biologique, Hôpital Lariboisière (AP-HP). FAU - Martin, Anne-Céline AU - Martin AC AD - INSERM UMR-S1140, Faculté de Pharmacie. AD - Université Paris Descartes, Sorbonne Paris Cité. AD - Hôpital d'Instruction des Armées Percy, Service de Cardiologie, Clamart. FAU - Pailleret, Claire AU - Pailleret C AD - INSERM UMR-S1140, Faculté de Pharmacie. AD - Université Paris Descartes, Sorbonne Paris Cité. AD - AP-HP, Hôpital Cochin, Paris. FAU - Vigué, Bernard AU - Vigué B AD - APHP, département d'anesthésie-Réanimation, CHU de Bicêtre, Le Kremlin Bicêtre. FAU - Zerbib, Yves AU - Zerbib Y AD - EA 4148 S2HEP. AD - CUMG/DMG, Faculté de médecine Lyon Est, Université Claude Bernard Lyon 1. FAU - Tazarourte, Karim AU - Tazarourte K AD - Emergency Department, Edouard Herriot Universitary Hospital, Hospices Civils de Lyon. AD - EA 7425 HESPER UCLB Lyon 1, Lyon, France. LA - eng PT - Journal Article PT - Review PL - England TA - Eur J Emerg Med JT - European journal of emergency medicine : official journal of the European Society for Emergency Medicine JID - 9442482 RN - 0 (Anticoagulants) RN - 12001-79-5 (Vitamin K) SB - IM MH - Anticoagulants/adverse effects/*therapeutic use MH - Dose-Response Relationship, Drug MH - Drug Administration Schedule MH - Emergencies MH - Emergency Medicine/*methods MH - Emergency Service, Hospital MH - Female MH - Hemorrhage/*chemically induced/prevention & control MH - Humans MH - International Normalized Ratio/standards MH - Male MH - Patient Safety MH - Primary Prevention/methods MH - Risk Assessment MH - Sensitivity and Specificity MH - Thrombosis/*prevention & control MH - Vitamin K/adverse effects/*antagonists & inhibitors/therapeutic use EDAT- 2018/02/21 06:00 MHDA- 2019/03/21 06:00 CRDT- 2018/02/21 06:00 PHST- 2018/02/21 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2018/02/21 06:00 [entrez] AID - 10.1097/MEJ.0000000000000541 [doi] PST - ppublish SO - Eur J Emerg Med. 2018 Dec;25(6):378-386. doi: 10.1097/MEJ.0000000000000541. PMID- 30345085 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200929 IS - 2062-509X (Print) IS - 2062-8633 (Electronic) IS - 2062-509X (Linking) VI - 8 IP - 3 DP - 2018 Sep 28 TI - Lipopolysaccharides in Food, Food Supplements, and Probiotics: Should We be Worried? PG - 63-69 LID - 10.1556/1886.2018.00017 [doi] AB - The fever-inducing effect of lipopolysaccharides (LPS) is well known, and human blood is extremely responsive to this pyrogen. Recently, the safety of LPS-containing food supplements and probiotic drugs as immune-stimulants has been questioned, although these products are orally taken and do not reach the bloodstream undigested. The concerns are understandable, as endotoxaemia is a pathological condition, but the oral uptake of probiotic products containing LPS or Gram-negative bacteria does not pose a health risk, based on the available scientific evidence, as is reviewed here. The available methods developed to detect LPS and other pyrogens are mostly used for quality control of parentally applied therapeuticals. Their outcome varies considerably when applied to food supplements, as demonstrated in a simple comparative experiment. Products containing different Escherichia coli strains can result in vastly different results on their LPS content, depending on the method of testing. This is an inherent complication to pyrogen testing, which hampers the communication that the LPS content of food supplements is not a safety concern. FAU - Wassenaar, Trudy M AU - Wassenaar TM AD - Molecular Microbiology and Genomics Consultancy, Tannenstrasse 7, 55576 Zotzenheim, Germany. FAU - Zimmermann, Kurt AU - Zimmermann K AD - SymbioPharm GmbH, Herborn, Germany. LA - eng PT - Journal Article PT - Review DEP - 20180821 PL - Hungary TA - Eur J Microbiol Immunol (Bp) JT - European journal of microbiology & immunology JID - 101569896 PMC - PMC6186019 OTO - NOTNLM OT - E. coli OT - LPS OT - endotoxaemia OT - oral intake OT - probiotic OT - safety COIS- Conflict of Interest T.M.W. works as a consultant for companies producing probiotics, including products that contain E. coli. K.Z. works for SymbioPharm GmbH and contributed to this work on personal title. EDAT- 2018/10/23 06:00 MHDA- 2018/10/23 06:01 PMCR- 2018/08/21 CRDT- 2018/10/23 06:00 PHST- 2018/07/03 00:00 [received] PHST- 2018/07/16 00:00 [accepted] PHST- 2018/10/23 06:00 [entrez] PHST- 2018/10/23 06:00 [pubmed] PHST- 2018/10/23 06:01 [medline] PHST- 2018/08/21 00:00 [pmc-release] AID - 10.1556/1886.2018.00017 [doi] PST - epublish SO - Eur J Microbiol Immunol (Bp). 2018 Aug 21;8(3):63-69. doi: 10.1556/1886.2018.00017. eCollection 2018 Sep 28. PMID- 25604306 OWN - NLM STAT- MEDLINE DCOM- 20151223 LR - 20181113 IS - 1433-0385 (Electronic) IS - 0009-4722 (Linking) VI - 86 IP - 2 DP - 2015 Feb TI - [Complication management after liver transplantation. Increasing patient safety by standardized approach and interdisciplinary cooperation]. PG - 139-45 LID - 10.1007/s00104-014-2883-y [doi] AB - The interdisciplinary management of postoperative complications in liver transplantation is of extreme importance. Due to organ shortage and prioritization of the most severely ill recipients in the model for end-stage liver disease (MELD)-based allocation, both donor and recipient associated morbidity are increasing. An interdisciplinary, structured monitoring concept is essential for the timely identification and specific treatment of postoperative complications. Interdisciplinary clinical rounds, laboratory testing and Doppler ultrasound monitoring of the graft perfusion are as important as comprehensive anti-infection prophylaxis and immunosuppression. Arterial perfusion disorders of any kind, biliary complications and postoperative fluid accumulation demand individualized therapeutic concepts. In summary, the success of liver transplantation depends on the communication and coordinated interdisciplinary cooperation of all disciplines involved. FAU - Houben, P AU - Houben P AD - Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, Kirschnerstr. 1, 69120, Heidelberg, Deutschland. FAU - Gotthardt, D N AU - Gotthardt DN FAU - Radeleff, B AU - Radeleff B FAU - Sauer, P AU - Sauer P FAU - Büchler, M W AU - Büchler MW FAU - Schemmer, P AU - Schemmer P LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Komplikationsmanagement nach Lebertransplantation. Erhöhung der Patientensicherheit durch standardisiertes Vorgehen und interdisziplinäre Kooperation. PL - Germany TA - Chirurg JT - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen JID - 16140410R SB - IM MH - *Cooperative Behavior MH - Graft Survival MH - Humans MH - *Interdisciplinary Communication MH - *Liver Transplantation MH - Patient Safety/*standards MH - Postoperative Complications/diagnosis/etiology/*therapy MH - Reoperation EDAT- 2015/01/22 06:00 MHDA- 2015/12/24 06:00 CRDT- 2015/01/22 06:00 PHST- 2015/01/22 06:00 [entrez] PHST- 2015/01/22 06:00 [pubmed] PHST- 2015/12/24 06:00 [medline] AID - 10.1007/s00104-014-2883-y [doi] PST - ppublish SO - Chirurg. 2015 Feb;86(2):139-45. doi: 10.1007/s00104-014-2883-y. PMID- 27296648 OWN - NLM STAT- MEDLINE DCOM- 20180813 LR - 20181202 IS - 1759-4820 (Electronic) IS - 1759-4812 (Linking) VI - 13 IP - 7 DP - 2016 Jul TI - Hypofractionated radiotherapy for organ-confined prostate cancer: is less more? PG - 400-8 LID - 10.1038/nrurol.2016.106 [doi] AB - Moderate hypofractionation of radiotherapy is widely considered a viable alternative to conventional fractionation for the treatment of patients with organ-confined prostate cancer, but stereotactic body radiotherapy (SBRT) is rapidly emerging as a novel treatment modality for this disease. Advances in treatment planning, image guidance, target position reproducibility and on-line tracking, coupled with a compelling radiobiological rationale, have promoted SBRT as a safe and effective treatment. Dose escalation to the tumour tissue through a decreased number of radiation fractions improves patient comfort and convenience, as well as treatment cost-effectiveness, compared with conventional radiotherapy regimens. Several clinical trials have investigated moderate and extreme hypofractionation of radiotherapy in patients with prostate cancer. Evidence is accumulating which suggests that the use of moderately hypofractionated radiotherapy can be recommended regardless of cancer risk group. Regimens of extremely hypofractionated radiotherapy have shown very good short-term efficacy and safety outcomes, but appropriately designed trials with extended follow-up monitoring are required to confirm long-term outcomes. FAU - Arcangeli, Stefano AU - Arcangeli S AD - Department of Radiation Oncology, Champalimaud Centre for the Unknown, Avenida Brasilia, 1400-038 Lisbon, Portugal. FAU - Greco, Carlo AU - Greco C AD - Department of Radiation Oncology, Champalimaud Centre for the Unknown, Avenida Brasilia, 1400-038 Lisbon, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20160614 PL - England TA - Nat Rev Urol JT - Nature reviews. Urology JID - 101500082 SB - IM MH - Clinical Trials as Topic/methods MH - Humans MH - Male MH - Prostatic Neoplasms/diagnosis/*radiotherapy MH - Radiation Dose Hypofractionation/*standards EDAT- 2016/06/15 06:00 MHDA- 2018/08/14 06:00 CRDT- 2016/06/15 06:00 PHST- 2016/06/15 06:00 [entrez] PHST- 2016/06/15 06:00 [pubmed] PHST- 2018/08/14 06:00 [medline] AID - nrurol.2016.106 [pii] AID - 10.1038/nrurol.2016.106 [doi] PST - ppublish SO - Nat Rev Urol. 2016 Jul;13(7):400-8. doi: 10.1038/nrurol.2016.106. Epub 2016 Jun 14. PMID- 39515223 OWN - NLM STAT- MEDLINE DCOM- 20241123 LR - 20241123 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 362 DP - 2024 Dec TI - Thermal comfort and gender affirmation: A virtual ethnography of extreme heat among trans women in Rio de Janeiro. PG - 117481 LID - S0277-9536(24)00935-3 [pii] LID - 10.1016/j.socscimed.2024.117481 [doi] AB - The multisensory experience of feeling hot, breathless, sweaty, and weak during heat spells among transgender people is a critically understudied area in both medical anthropology and thermal comfort research. This article contributes to the anthropology of heat and humidity by intersecting with health and thermal comfort studies. Through virtual ethnography with three trans women in Rio de Janeiro in 2021 and 2022, the research reveals that trans women in the city face heightened risks of heat stress and thermal discomfort due to unsafe living conditions, side effects of gender-affirming modifications, and social discrimination. These findings highlight the urgent need to address the specific challenges transgender individuals face in accessing thermal safety and underscore the importance of considering their unique needs. CI - Copyright © 2024 The Author. Published by Elsevier Ltd.. All rights reserved. FAU - Mazzone, Antonella AU - Mazzone A AD - University of Bristol, 43 Woodland Rd, Bristol BS8 1TH, United Kingdom. Electronic address: Antonella.mazzone@bristol.ac.uk. LA - eng PT - Journal Article DEP - 20241105 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - *Transgender Persons/psychology MH - Female MH - Brazil MH - *Anthropology, Cultural MH - Extreme Heat/adverse effects MH - Adult MH - Male OTO - NOTNLM OT - Climate change OT - Heat vulnerability OT - Sexuality OT - Thermal comfort OT - Transgender EDAT- 2024/11/13 13:53 MHDA- 2024/11/24 00:44 CRDT- 2024/11/08 18:11 PHST- 2024/05/22 00:00 [received] PHST- 2024/10/24 00:00 [revised] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/11/24 00:44 [medline] PHST- 2024/11/13 13:53 [pubmed] PHST- 2024/11/08 18:11 [entrez] AID - S0277-9536(24)00935-3 [pii] AID - 10.1016/j.socscimed.2024.117481 [doi] PST - ppublish SO - Soc Sci Med. 2024 Dec;362:117481. doi: 10.1016/j.socscimed.2024.117481. Epub 2024 Nov 5. PMID- 21616941 OWN - NLM STAT- MEDLINE DCOM- 20110823 LR - 20211020 IS - 1471-6771 (Electronic) IS - 0007-0912 (Print) IS - 0007-0912 (Linking) VI - 107 IP - 1 DP - 2011 Jul TI - Are anaesthetics toxic to the brain? PG - 30-7 LID - 10.1093/bja/aer122 [doi] AB - It has been assumed that anaesthetics have minimal or no persistent effects after emergence from anaesthesia. However, general anaesthetics act on multiple ion channels, receptors, and cell signalling systems in the central nervous system to produce anaesthesia, so it should come as no surprise that they also have non-anaesthetic actions that range from beneficial to detrimental. Accumulating evidence is forcing the anaesthesia community to question the safety of general anaesthesia at the extremes of age. Preclinical data suggest that inhaled anaesthetics can have profound and long-lasting effects during key neurodevelopmental periods in neonatal animals by increasing neuronal cell death (apoptosis) and reducing neurogenesis. Clinical data remain conflicting on the significance of these laboratory data to the paediatric population. At the opposite extreme in age, elderly patients are recognized to be at an increased risk of postoperative cognitive dysfunction (POCD) with a well-recognized decline in cognitive function after surgery. The underlying mechanisms and the contribution of anaesthesia in particular to POCD remain unclear. Laboratory models suggest anaesthetic interactions with neurodegenerative mechanisms, such as those linked to the onset and progression of Alzheimer's disease, but their clinical relevance remains inconclusive. Prospective randomized clinical trials are underway to address the clinical significance of these findings, but there are major challenges in designing, executing, and interpreting such trials. It is unlikely that definitive clinical studies absolving general anaesthetics of neurotoxicity will become available in the near future, requiring clinicians to use careful judgement when using these profound neurodepressants in vulnerable patients. FAU - Hudson, A E AU - Hudson AE AD - Department of Anesthesiology, Weill Cornell Medical College, New York, NY 10065, USA. FAU - Hemmings, H C Jr AU - Hemmings HC Jr LA - eng GR - R01 NS056315/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review DEP - 20110526 PL - England TA - Br J Anaesth JT - British journal of anaesthesia JID - 0372541 RN - 0 (Anesthetics, General) SB - IM MH - Aged MH - Anesthetics, General/*adverse effects/toxicity MH - Animals MH - Brain/*drug effects/growth & development MH - Cognition Disorders/*chemically induced MH - Disease Models, Animal MH - Humans MH - Postoperative Complications/*chemically induced PMC - PMC3159425 EDAT- 2011/05/28 06:00 MHDA- 2011/08/24 06:00 PMCR- 2012/07/01 CRDT- 2011/05/28 06:00 PHST- 2011/05/28 06:00 [entrez] PHST- 2011/05/28 06:00 [pubmed] PHST- 2011/08/24 06:00 [medline] PHST- 2012/07/01 00:00 [pmc-release] AID - S0007-0912(17)33149-5 [pii] AID - aer122 [pii] AID - 10.1093/bja/aer122 [doi] PST - ppublish SO - Br J Anaesth. 2011 Jul;107(1):30-7. doi: 10.1093/bja/aer122. Epub 2011 May 26. PMID- 34717203 OWN - NLM STAT- MEDLINE DCOM- 20211122 LR - 20211122 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 163 DP - 2021 Dec TI - Exploring the associations between winter maintenance operations, weather variables, surface condition, and road safety: A path analysis approach. PG - 106448 LID - S0001-4575(21)00479-6 [pii] LID - 10.1016/j.aap.2021.106448 [doi] AB - This paper aims to assess the effects of snow and ice control operations by investigating the interdependency between weather variables, maintenance operations, pavement friction, and collisions. Using a disaggregated event-based and location-specific framework, and employing the statistical techniques of Structural Equation Modeling and Path Analysis, all the significant direct and indirect effects of weather variables and maintenance operations on pavement friction and collision occurrence during snowstorms have been identified. It was revealed that precipitation, extremely low temperatures, and the potential of black ice formation all had significant negative direct effects on pavement friction and significant indirect negative effects on traffic safety. Moreover, the application of anti-icing agents and plowing operations have been shown to significantly improve pavement friction and in return improve traffic safety indirectly. To illustrate how the maintenance operations improve traffic safety, a hypothetical snowstorm example was considered. According to the model, anti-icing application was associated with a 14% reduction in collisions, plowing operations resulted in a 33% reduction in collisions, and combining the two tools reduced collisions per snowstorm by 42%. The findings of this paper can help transportation agencies make more informed decisions to promote an efficient mobilization of the existing winter road maintenance services and resources while improving the safety of the traveling public during the winter months. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Abohassan, Ahmed AU - Abohassan A AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G1H9, Canada. Electronic address: anasser@ualberta.ca. FAU - El-Basyouny, Karim AU - El-Basyouny K AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G1H9, Canada; City of Edmonton's Urban Traffic Safety Research Chair, Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G1H9, Canada. Electronic address: basyouny@ualberta.ca. FAU - Kwon, Tae J AU - Kwon TJ AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB T6G1H9, Canada. Electronic address: tjkwon@ualberta.ca. LA - eng PT - Journal Article DEP - 20211028 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - *Accidents, Traffic/prevention & control MH - Humans MH - Safety MH - Seasons MH - Snow MH - *Weather OTO - NOTNLM OT - Anti-icing OT - Snow plowing OT - Snowstorms OT - Structural equation modeling OT - Traffic safety OT - Winter road maintenance operations EDAT- 2021/10/31 06:00 MHDA- 2021/11/23 06:00 CRDT- 2021/10/30 20:12 PHST- 2021/07/12 00:00 [received] PHST- 2021/09/13 00:00 [revised] PHST- 2021/10/08 00:00 [accepted] PHST- 2021/10/31 06:00 [pubmed] PHST- 2021/11/23 06:00 [medline] PHST- 2021/10/30 20:12 [entrez] AID - S0001-4575(21)00479-6 [pii] AID - 10.1016/j.aap.2021.106448 [doi] PST - ppublish SO - Accid Anal Prev. 2021 Dec;163:106448. doi: 10.1016/j.aap.2021.106448. Epub 2021 Oct 28. PMID- 27277564 OWN - NLM STAT- MEDLINE DCOM- 20170131 LR - 20220408 IS - 1715-5320 (Electronic) IS - 1715-5312 (Linking) VI - 41 IP - 6 Suppl 2 DP - 2016 Jun TI - Thermal stress, human performance, and physical employment standards. PG - S148-64 LID - 10.1139/apnm-2015-0518 [doi] AB - Many physically demanding occupations in both developed and developing economies involve exposure to extreme thermal environments that can affect work capacity and ultimately health. Thermal extremes may be present in either an outdoor or an indoor work environment, and can be due to a combination of the natural or artificial ambient environment, the rate of metabolic heat generation from physical work, processes specific to the workplace (e.g., steel manufacturing), or through the requirement for protective clothing impairing heat dissipation. Together, thermal exposure can elicit acute impairment of work capacity and also chronic effects on health, greatly contributing to worker health risk and reduced productivity. Surprisingly, in most occupations even in developed economies, there are rarely any standards regarding enforced heat or cold safety for workers. Furthermore, specific physical employment standards or accommodations for thermal stressors are rare, with workers commonly tested under near-perfect conditions. This review surveys the major occupational impact of thermal extremes and existing employment standards, proposing guidelines for improvement and areas for future research. FAU - Cheung, Stephen S AU - Cheung SS AD - a Environmental Ergonomics Laboratory, Department of Kinesiology, Brock University, 1812 Sir Isaac Brock Way, St. Catharines, ON L2S 3A1, Canada. FAU - Lee, Jason K W AU - Lee JK AD - b Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore. AD - c Yong Loo Lin School of Medicine, National University of Singapore, Singapore. AD - d Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Oksa, Juha AU - Oksa J AD - e Finnish Institute of Occupational Health, Physical Work Capacity team, Oulu, Finland. LA - eng PT - Journal Article PT - Review PL - Canada TA - Appl Physiol Nutr Metab JT - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JID - 101264333 SB - IM MH - Animals MH - *Cold Temperature MH - Employment/*standards MH - Firefighters MH - Guidelines as Topic/standards MH - *Hot Temperature MH - Humans MH - Military Personnel MH - Miners MH - Occupational Health/*standards MH - Physical Fitness MH - *Stress, Physiological MH - Workplace/*standards OTO - NOTNLM OT - Heat stress OT - cold stress OT - occupational physiology OT - physiologie du travail OT - stress dû au froid OT - stress thermique OT - testing OT - travail OT - work OT - évaluation EDAT- 2016/06/10 06:00 MHDA- 2017/02/01 06:00 CRDT- 2016/06/10 06:00 PHST- 2016/06/10 06:00 [entrez] PHST- 2016/06/10 06:00 [pubmed] PHST- 2017/02/01 06:00 [medline] AID - 10.1139/apnm-2015-0518 [doi] PST - ppublish SO - Appl Physiol Nutr Metab. 2016 Jun;41(6 Suppl 2):S148-64. doi: 10.1139/apnm-2015-0518. PMID- 27817217 OWN - NLM STAT- MEDLINE DCOM- 20171026 LR - 20180228 IS - 1744-8387 (Electronic) IS - 1478-9450 (Linking) VI - 14 IP - 1 DP - 2017 Jan TI - Spaceflight induced changes in the human proteome. PG - 15-29 LID - 10.1080/14789450.2017.1258307 [doi] AB - Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions. FAU - Kononikhin, Alexey S AU - Kononikhin AS AD - a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia. AD - b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia. AD - d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia. FAU - Starodubtseva, Natalia L AU - Starodubtseva NL AD - b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia. AD - c V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology , Laboratory of proteomics and metabolomics, Ministry of Healthcare of the Russian Federation , Moscow , Russia. AD - d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia. FAU - Pastushkova, Lyudmila Kh AU - Pastushkova LK AD - a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia. FAU - Kashirina, Daria N AU - Kashirina DN AD - a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia. FAU - Fedorchenko, Kristina Yu AU - Fedorchenko KY AD - e Emanuel Institute for Biochemical Physics , Russian Academy of Sciences , Moscow , Russia. FAU - Brhozovsky, Alexander G AU - Brhozovsky AG AD - a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia. FAU - Popov, Igor A AU - Popov IA AD - b Moscow Institute of Physics and Technology , Laboratory of ion and molecular physics , Moscow , Russia. AD - c V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology , Laboratory of proteomics and metabolomics, Ministry of Healthcare of the Russian Federation , Moscow , Russia. AD - d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia. FAU - Larina, Irina M AU - Larina IM AD - a Institute of Biomedical Problems - Russian Federation State Scientific Research Center, Laboratory of proteomics , Russian Academy of Sciences , Moscow , Russia. FAU - Nikolaev, Evgeny N AU - Nikolaev EN AD - d V.L. Talrose Institute for Energy Problems of Chemical Physics , Laboratory of ion and molecular physics, Russian Academy of Sciences , Moscow , Russia. AD - e Emanuel Institute for Biochemical Physics , Russian Academy of Sciences , Moscow , Russia. AD - f Skolkovo Institute of Science and Technology, Space Cluster , Skolkovo , Russia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20161121 PL - England TA - Expert Rev Proteomics JT - Expert review of proteomics JID - 101223548 RN - 0 (Proteome) SB - IM MH - Humans MH - Proteome/*genetics MH - *Proteomics MH - *Space Flight MH - Weightlessness/*adverse effects OTO - NOTNLM OT - MARS 500 OT - Spaceflight OT - bed rest study OT - dry immersion OT - extreme conditions OT - human proteome OT - microgravity OT - proteomics OT - spaceflight simulation EDAT- 2016/11/08 06:00 MHDA- 2017/10/27 06:00 CRDT- 2016/11/08 06:00 PHST- 2016/11/08 06:00 [pubmed] PHST- 2017/10/27 06:00 [medline] PHST- 2016/11/08 06:00 [entrez] AID - 10.1080/14789450.2017.1258307 [doi] PST - ppublish SO - Expert Rev Proteomics. 2017 Jan;14(1):15-29. doi: 10.1080/14789450.2017.1258307. Epub 2016 Nov 21. PMID- 28338739 OWN - NLM STAT- MEDLINE DCOM- 20180119 LR - 20181202 IS - 1758-4469 (Electronic) IS - 0829-318X (Linking) VI - 37 IP - 4 DP - 2017 Apr 1 TI - Retention of stored water enables tropical tree saplings to survive extreme drought conditions. PG - 469-480 LID - 10.1093/treephys/tpx001 [doi] AB - Trees generally maintain a small safety margin between the stem water potential (Ψstem) reached during seasonal droughts and the Ψstem associated with their mortality. This pattern may indicate that species face similar mortality risk during extreme droughts. However, if tree species vary in their ability to regulate Ψstem, then safety margins would poorly predict drought mortality. To explore variation among species in Ψstem regulation, I subjected potted saplings of six tropical tree species to extreme drought and compared their responses with well-watered plants and pretreatment reference plants. In the drought treatment, soil water potential reached <-10 MPa, yet three species, Bursera simaruba (L.) Sarg., Cavanillesia platanifolia (Bonpl.) Kunth and Cedrela odorata L. had 100% survival and maintained Ψstem near -1 MPa (i.e., desiccation-avoiding species). Three other species, Cojoba rufescens (Benth.) Britton and Rose, Genipa americana L. and Hymenaea courbaril L. had 50%, 0% and 25% survival, respectively, and survivors had Ψstem <-6 MPa (i.e., desiccation-susceptible species). The desiccation-avoiding species had lower relative water content (RWC) in all organs and tissues (root, stem, bark and xylem) in the drought treatment than in the reference plants (means 72.0-90.4% vs 86.9-97.9%), but the survivors of the desiccation-susceptible C. rufescens had much lower RWC in the drought treatment (44.5-72.1%). Among the reference plants, the desiccation-avoiding species had lower tissue density, leaf-mass fraction and lateral-root surface area (LRA) than the desiccation-susceptible species. Additionally, C. platanifolia and C. odorata had reduced LRA in the drought treatment, which may slow water loss into dry soil. Together, these results suggest that the ability to regulate Ψstem during extreme drought is associated with functional traits that favor retention of stored water and that safety margins during seasonal drought poorly predict survival during extreme drought. CI - © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Wolfe, Brett T AU - Wolfe BT AD - Department of Biology, University of Utah, Salt Lake City, UT 84112, USA. AD - Smithsonian Tropical Research Institute, PO Box 0843-03092, Balboa, Republic of Panama. LA - eng PT - Journal Article PL - Canada TA - Tree Physiol JT - Tree physiology JID - 100955338 RN - 059QF0KO0R (Water) SB - IM MH - *Droughts MH - Plant Bark/physiology MH - Plant Roots/physiology MH - Plant Stems/physiology MH - Trees/*physiology MH - Water/*physiology MH - Xylem/physiology OTO - NOTNLM OT - climate change drought OT - deciduousness OT - drought responses OT - root dynamics OT - seasonally dry tropical forest OT - water storage EDAT- 2017/03/25 06:00 MHDA- 2018/01/20 06:00 CRDT- 2017/03/25 06:00 PHST- 2016/07/25 00:00 [received] PHST- 2017/01/24 00:00 [accepted] PHST- 2017/03/25 06:00 [pubmed] PHST- 2018/01/20 06:00 [medline] PHST- 2017/03/25 06:00 [entrez] AID - 2979778 [pii] AID - 10.1093/treephys/tpx001 [doi] PST - ppublish SO - Tree Physiol. 2017 Apr 1;37(4):469-480. doi: 10.1093/treephys/tpx001. PMID- 38477222 OWN - NLM STAT- MEDLINE DCOM- 20240314 LR - 20240515 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 23 IP - 2 DP - 2024 Mar TI - Changing climate, shifting mycotoxins: A comprehensive review of climate change impact on mycotoxin contamination. PG - e13323 LID - 10.1111/1541-4337.13323 [doi] AB - Climate change (CC) is a complex phenomenon that has the potential to significantly alter marine, terrestrial, and freshwater ecosystems worldwide. Global warming of 2°C is expected to be exceeded during the 21st century, and the frequency of extreme weather events, including floods, storms, droughts, extreme temperatures, and wildfires, has intensified globally over recent decades, differently affecting areas of the world. How CC may impact multiple food safety hazards is increasingly evident, with mycotoxin contamination in particular gaining in prominence. Research focusing on CC effects on mycotoxin contamination in edible crops has developed considerably throughout the years. Therefore, we conducted a comprehensive literature search to collect available studies in the scientific literature published between 2000 and 2023. The selected papers highlighted how warmer temperatures are enabling the migration, introduction, and mounting abundance of thermophilic and thermotolerant fungal species, including those producing mycotoxins. Certain mycotoxigenic fungal species, such as Aspergillus flavus and Fusarium graminearum, are expected to readily acclimatize to new conditions and could become more aggressive pathogens. Furthermore, abiotic stress factors resulting from CC are expected to weaken the resistance of host crops, rendering them more vulnerable to fungal disease outbreaks. Changed interactions of mycotoxigenic fungi are likewise expected, with the effect of influencing the prevalence and co-occurrence of mycotoxins in the future. Looking ahead, future research should focus on improving predictive modeling, expanding research into different pathosystems, and facilitating the application of effective strategies to mitigate the impact of CC. CI - © 2024 The Authors. Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists. FAU - Casu, Alessia AU - Casu A AUID- ORCID: 0009-0000-5044-4329 AD - Department of Sustainable Crop Production, Università Cattolica del Sacro Cuore, Piacenza, Italy. FAU - Camardo Leggieri, Marco AU - Camardo Leggieri M AD - Department of Sustainable Crop Production, Università Cattolica del Sacro Cuore, Piacenza, Italy. FAU - Toscano, Piero AU - Toscano P AD - IBE-CNR, Institute of BioEconomy-National Research Council, Firenze, Italia. FAU - Battilani, Paola AU - Battilani P AD - Department of Sustainable Crop Production, Università Cattolica del Sacro Cuore, Piacenza, Italy. LA - eng PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 RN - 0 (Mycotoxins) SB - IM MH - *Mycotoxins/analysis MH - Climate Change MH - Ecosystem MH - Food Contamination/analysis MH - Food Safety MH - Crops, Agricultural/microbiology OTO - NOTNLM OT - aspergillus flavus OT - fungi OT - fusarium spp OT - global warming OT - grape OT - maize OT - occurrence OT - pathosystem OT - toxins OT - wheat EDAT- 2024/03/13 06:47 MHDA- 2024/03/14 06:46 CRDT- 2024/03/13 05:44 PHST- 2024/02/20 00:00 [revised] PHST- 2023/09/27 00:00 [received] PHST- 2024/02/28 00:00 [accepted] PHST- 2024/03/14 06:46 [medline] PHST- 2024/03/13 06:47 [pubmed] PHST- 2024/03/13 05:44 [entrez] AID - 10.1111/1541-4337.13323 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2024 Mar;23(2):e13323. doi: 10.1111/1541-4337.13323. PMID- 9366608 OWN - NLM STAT- MEDLINE DCOM- 19971209 LR - 20181113 IS - 1080-6040 (Print) IS - 1080-6059 (Electronic) IS - 1080-6040 (Linking) VI - 3 IP - 4 DP - 1997 Oct-Dec TI - Quantitative microbiology: a basis for food safety. PG - 541-9 AB - Because microorganisms are easily dispersed, display physiologic diversity, and tolerate extreme conditions, they are ubiquitous and may contaminate and grow in many food products. The behavior of microbial populations in foods (growth, survival, or death) is determined by the properties of the food (e.g., water activity and pH) and the storage conditions (e.g., temperature, relative humidity, and atmosphere). The effect of these properties can be predicted by mathematical models derived from quantitative studies on microbial populations. Temperature abuse is a major factor contributing to foodborne disease; monitoring temperature history during food processing, distribution, and storage is a simple, effective means to reduce the incidence of food poisoning. Interpretation of temperature profiles by computer programs based on predictive models allows informed decisions on the shelf life and safety of foods. In- or on-package temperature indicators require further development to accurately predict microbial behavior. We suggest a basis for a "universal" temperature indicator. This article emphasizes the need to combine kinetic and probability approaches to modeling and suggests a method to define the bacterial growth/no growth interface. Advances in controlling foodborne pathogens depend on understanding the pathogens' physiologic responses to growth constraints, including constraints conferring increased survival capacity. FAU - McMeekin, T A AU - McMeekin TA AD - Department of Agricultural Science, University of Tasmania, Hobart, Australia. Tom.McMeekin@utas.edu.au FAU - Brown, J AU - Brown J FAU - Krist, K AU - Krist K FAU - Miles, D AU - Miles D FAU - Neumeyer, K AU - Neumeyer K FAU - Nichols, D S AU - Nichols DS FAU - Olley, J AU - Olley J FAU - Presser, K AU - Presser K FAU - Ratkowsky, D A AU - Ratkowsky DA FAU - Ross, T AU - Ross T FAU - Salter, M AU - Salter M FAU - Soontranon, S AU - Soontranon S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Emerg Infect Dis JT - Emerging infectious diseases JID - 9508155 SB - IM MH - Bacteria/growth & development MH - *Food Microbiology MH - Humans MH - Hydrogen-Ion Concentration MH - Research MH - Temperature PMC - PMC2640082 EDAT- 1997/11/21 00:00 MHDA- 1997/11/21 00:01 PMCR- 1997/10/01 CRDT- 1997/11/21 00:00 PHST- 1997/11/21 00:00 [pubmed] PHST- 1997/11/21 00:01 [medline] PHST- 1997/11/21 00:00 [entrez] PHST- 1997/10/01 00:00 [pmc-release] AID - 10.3201/eid0304.970419 [doi] PST - ppublish SO - Emerg Infect Dis. 1997 Oct-Dec;3(4):541-9. doi: 10.3201/eid0304.970419. PMID- 30927392 OWN - NLM STAT- MEDLINE DCOM- 20190523 LR - 20190523 IS - 1210-7778 (Print) IS - 1210-7778 (Linking) VI - 27 IP - 1 DP - 2019 Mar TI - Examination of life quality, mental conditions and cognitive status of people over the age of 90: Results of a Hungarian local research. PG - 17-23 LID - 10.21101/cejph.a4753 [doi] AB - OBJECTIVES: The study presents the findings of a quantitative research conducted among people aged over 90, who live in a large town of Hungary, Debrecen. The aim of the research was to examine the lifestyle, attitudes, values, and physical and mental condition of old and long-lived people. We laid a special emphasis on the exploration of the life perspectives, mood and mental youth, and their interconnections. METHODS: The sociological questionnaire used for data collection (159 questions) was intended to inquire socio-demographic characteristics, dietary habits, health condition, physical activity, and identity features. Further examinations were conducted in order to measure the level of depression using the Geriatric Depression Scale (GDS) and mental condition using the Mini-Mental State Examination (MMSE). We managed to reach out to the elderly living in the town on the basis of family doctors' districts (N = 212). We dealt with a subsample of 115 people since we got answers for all questions from them. During data processing, we applied multivariate statistical methods, first of all linear regression analysis and cluster analysis. We examined the differences between clusters using variation analysis. RESULTS: According to our results, the extremely low educational level of the elderly belonging to the target group did not decrease their life perspectives, but it had a significant impact on the age when their illness begun. We revealed a connection between the mental condition and the level of depression. Better mental condition (higher MMSE) resulted in lower depression level (low GDS). One of our main finding is that the change in the level of depression (GDS) is 13.4% due to the change in the mental condition (MMSE). CONCLUSIONS: Physical and mental activity, personal autonomy, a wide range of activities, and avoiding isolation and solitude allow people to experience quality ageing; all these factors can be substantially influenced by the status acquired at a younger age. We believe that it is extremely important for the society to develop guarantees for active old age, which would ensure the optimal balance between the possibilities of physical and mental health, social participation and safety. FAU - Czibere, Ibolya AU - Czibere I AD - Department of Sociology and Social Policy, University of Debrecen, Debrecen, Hungary. FAU - Rácz, Andrea AU - Rácz A AD - Department of Social Work, University of Eotvos Lorand, Budapest, Hungary. FAU - Szilvási, Henrietta AU - Szilvási H AD - Gerontology Research Group, Institute of Internal Medicine, University of Debrecen, Debrecen, Hungary. FAU - Szikszai, Zita AU - Szikszai Z AD - Institute for Nuclear Research, Hungarian Academy of Science, Debrecen, Hungary. FAU - Imre, Sándor AU - Imre S AD - Gerontology Research Group, Institute of Internal Medicine, University of Debrecen, Debrecen, Hungary. LA - eng PT - Journal Article PL - Czech Republic TA - Cent Eur J Public Health JT - Central European journal of public health JID - 9417324 SB - IM MH - Aged MH - Aging/physiology/*psychology MH - Cognition/*physiology MH - Depression/*diagnosis/epidemiology MH - Geriatric Assessment MH - Health Status MH - Humans MH - Hungary/epidemiology MH - Life Style MH - *Mental Health MH - Psychiatric Status Rating Scales MH - Quality of Life/*psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - elderly people in the society OT - life quality of the elderly OT - long life OT - mental health of the elderly OT - super old EDAT- 2019/03/31 06:00 MHDA- 2019/05/24 06:00 CRDT- 2019/03/31 06:00 PHST- 2016/03/01 00:00 [received] PHST- 2019/03/31 06:00 [entrez] PHST- 2019/03/31 06:00 [pubmed] PHST- 2019/05/24 06:00 [medline] AID - 10.21101/cejph.a4753 [doi] PST - ppublish SO - Cent Eur J Public Health. 2019 Mar;27(1):17-23. doi: 10.21101/cejph.a4753. PMID- 24501480 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140624 LR - 20211021 IS - 0970-0358 (Print) IS - 1998-376X (Electronic) IS - 0970-0358 (Linking) VI - 46 IP - 2 DP - 2013 May TI - Anaesthetic complications in plastic surgery. PG - 445-52 LID - 10.4103/0970-0358.118626 [doi] AB - Anaesthesia related complications in plastic surgeries are fortunately rare, but potentially catastrophic. Maintaining patient safety in the operating room is a major concern of anaesthesiologists, surgeons, hospitals and surgical facilities. Circumventing preventable complications is essential and pressure to avoid these complications in cosmetic surgery is increasing. Key aspects of patient safety in the operating room are outlined, including patient positioning, airway management and issues related to some specific conditions, essential for minimizing post-operative morbidity. Risks associated with extremes of age in the plastic surgery population, may be minimised by a better understanding of the physiologic changes as well as the pre-operative and post-operative considerations in caring for this special group of patients. An understanding of the anaesthesiologist's concerns during paediatric plastic surgical procedures can facilitate the coordination of efforts between the multiple services involved in the care of these children. Finally, the reader will have a better understanding of the perioperative care of unique populations including the morbidly obese and the elderly. Attention to detail in these aspects of patient safety can help avoid unnecessary complication and significantly improve the patients' experience and surgical outcome. FAU - Nath, Soumya Sankar AU - Nath SS AD - Department of Anaesthesiology, Sahara India Medical Institute Ltd., Lucknow, Uttar Pradesh, India. FAU - Roy, Debashis AU - Roy D AD - Department of Anesthesia, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Ansari, Farrukh AU - Ansari F AD - Department of Anaesthesiology, Sahara India Medical Institute Ltd., Lucknow, Uttar Pradesh, India. FAU - Pawar, Sundeep T AU - Pawar ST AD - Department of Anaesthesiology, Sahara India Medical Institute Ltd., Lucknow, Uttar Pradesh, India. LA - eng PT - Journal Article PT - Review PL - Germany TA - Indian J Plast Surg JT - Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India JID - 8405356 PMC - PMC3901926 OTO - NOTNLM OT - Anaesthesia OT - complications OT - plastic OT - surgery COIS- Conflict of Interest: None declared. EDAT- 2014/02/07 06:00 MHDA- 2014/02/07 06:01 PMCR- 2013/05/01 CRDT- 2014/02/07 06:00 PHST- 2014/02/07 06:00 [entrez] PHST- 2014/02/07 06:00 [pubmed] PHST- 2014/02/07 06:01 [medline] PHST- 2013/05/01 00:00 [pmc-release] AID - IJPS-46-445 [pii] AID - 10.4103/0970-0358.118626 [doi] PST - ppublish SO - Indian J Plast Surg. 2013 May;46(2):445-52. doi: 10.4103/0970-0358.118626. PMID- 34984491 OWN - NLM STAT- MEDLINE DCOM- 20220404 LR - 20220405 IS - 1432-1246 (Electronic) IS - 0340-0131 (Linking) VI - 95 IP - 2 DP - 2022 Mar TI - Physiological impacts on construction workers under extremely hot and humid weather. PG - 315-329 LID - 10.1007/s00420-021-01785-w [doi] AB - PURPOSE: Construction worker health and safety is a primary concern for construction companies and researchers. Arabian Gulf region, like Saudi Arabia, has been experiencing extremely hot and humid (EHH) weather, which directly affects construction workers' health and safety. This study aims to address the problem of EHH weather conditions and their impacts on construction workers' physiological status. METHODS: This study assesses the impacts of EHH weather on construction workers' physiological status through the measurement of workers' physical body parameters (age, height, and weight); type of activities; and assigned tasks. Thirty-five multinational workers participated in the measurements, which were conducted in real construction site conditions A quantitative analysis was then applied to quantify the physiological impacts of the weather conditions. Several hypotheses were tested to identify the significant impacts of individual and working aspects on the workers' physiological responses. RESULTS AND CONCLUSION: The results provide empirical evidence that the recorded Heart Rate (HR) exceeded the acceptable physiological zones for construction workers exposed to extremely hot and humid weather conditions. Physical body parameters, work activities, and worker status significantly influence construction workers' physiological responses. This study recommends adopting a continuous monitoring approach as an early warning system under extremely hot and humid weather conditions. CI - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Moohialdin, Ammar AU - Moohialdin A AUID- ORCID: 0000-0002-9055-9558 AD - QMS and ISO Lead Auditor, Associate Fellow of the HEA, QUT - Gardens Point Campus, Brisbane, Australia. FAU - Trigunarsyah, Bambang AU - Trigunarsyah B AUID- ORCID: 0000-0001-6799-4781 AD - School of Property, Construction and Project Management, RMIT University, Melbourne, Australia. FAU - Islam, Muhammad Saiful AU - Islam MS AUID- ORCID: 0000-0002-6414-1211 AD - Construction Engineering and Management, King Fahd University of Petroleum and Minerals, Dhahran, 31261, Saudi Arabia. muhammad.islam@kfupm.edu.au. FAU - Siddiqui, Mohsin K AU - Siddiqui MK AUID- ORCID: 0000-0002-8964-0615 AD - Civil and Environmental Engineering - Construction Engineering and Management, University of Delaware, 342C Dupont Hall, Newark, DE 19716, USA. LA - eng PT - Journal Article DEP - 20220104 PL - Germany TA - Int Arch Occup Environ Health JT - International archives of occupational and environmental health JID - 7512134 SB - IM MH - *Construction Industry MH - Hot Temperature MH - Humans MH - *Occupational Health MH - Weather MH - Workplace OTO - NOTNLM OT - Arabian Gulf (AG) OT - Construction workers OT - Extremely hot and humid (EHH) OT - Health and safety (HS) OT - Kingdom of Saudi Arabia (KSA) OT - Physiological status monitoring (PSM) EDAT- 2022/01/06 06:00 MHDA- 2022/04/05 06:00 CRDT- 2022/01/05 06:02 PHST- 2021/01/27 00:00 [received] PHST- 2021/07/15 00:00 [accepted] PHST- 2022/01/06 06:00 [pubmed] PHST- 2022/04/05 06:00 [medline] PHST- 2022/01/05 06:02 [entrez] AID - 10.1007/s00420-021-01785-w [pii] AID - 10.1007/s00420-021-01785-w [doi] PST - ppublish SO - Int Arch Occup Environ Health. 2022 Mar;95(2):315-329. doi: 10.1007/s00420-021-01785-w. Epub 2022 Jan 4. PMID- 37464073 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230721 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Jul 18 TI - Torque coordinated control of the through-the-road (TTR) 4-wheel-drive (4WD) hybrid vehicle under extreme road conditions. PG - 11564 LID - 10.1038/s41598-023-38813-3 [doi] LID - 11564 AB - Vehicular safety is of considerable significance to the intelligent development of hybrid vehicles. However, the real-time stability control or reasonable torque distribution under the extreme road conditions remain a huge challenge due to the multiple uncertain parameters and difficulties to reconcile the handling and stability performance. To address the above problems for a through-the-road (TTR) 4-wheel-drive (4WD) hybrid vehicle, this study provides a handling and stability management (HSM) approach by incorporating the offline optimization rules and on-line model predictive control (MPC). Firstly, the vehicle dynamic model with seven degrees of freedom (7-DOF) is used to offline extract torque distribution rules (Offline-ETDR), and the online MPC feedback (Online-MPCF) is utilized to compensate the extra torque requirements for the poor effect under the extreme conditions. Accordingly, the offline optimization results and online correction are fused to provide the total torque demand given the real-time road condition detection. Finally, the real vehicle test are implemented to validate the effectiveness of the proposed torque coordination strategy. In comparison to the vehicle with no torque control strategy, the proposed method significantly improves the vehicle's cornering ability while also ensuring the high stability performance. CI - © 2023. The Author(s). FAU - Fan, Likang AU - Fan L AD - Vehicle Measurement, Control and Safety Key Laboratory of Sichuan Province, Xihua University, Chengdu, 100089, Sichuan, China. AD - Low Emission Vehicle Research Laboratory, Beijing Institute of Technology, Beijing, 100081, China. FAU - Wang, Jun AU - Wang J AD - Mianyang Fulin Precision Co, Ltd, Fenghuang Middle Road #37, Fucheng Disctrict, Mianyang, Sichuan, China. FAU - Deng, Meng AU - Deng M AD - Mianyang Fulin Precision Co, Ltd, Fenghuang Middle Road #37, Fucheng Disctrict, Mianyang, Sichuan, China. FAU - Peng, Yiqiang AU - Peng Y AD - Vehicle Measurement, Control and Safety Key Laboratory of Sichuan Province, Xihua University, Chengdu, 100089, Sichuan, China. FAU - Bao, Xiuchao AU - Bao X AD - Vehicle Measurement, Control and Safety Key Laboratory of Sichuan Province, Xihua University, Chengdu, 100089, Sichuan, China. FAU - Wei, Hongqian AU - Wei H AD - Low Emission Vehicle Research Laboratory, Beijing Institute of Technology, Beijing, 100081, China. bit_hongqian@126.com. LA - eng PT - Journal Article DEP - 20230718 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC10354040 COIS- The authors declare no competing interests. EDAT- 2023/07/19 01:06 MHDA- 2023/07/19 01:07 PMCR- 2023/07/18 CRDT- 2023/07/18 23:28 PHST- 2023/02/10 00:00 [received] PHST- 2023/07/15 00:00 [accepted] PHST- 2023/07/19 01:07 [medline] PHST- 2023/07/19 01:06 [pubmed] PHST- 2023/07/18 23:28 [entrez] PHST- 2023/07/18 00:00 [pmc-release] AID - 10.1038/s41598-023-38813-3 [pii] AID - 38813 [pii] AID - 10.1038/s41598-023-38813-3 [doi] PST - epublish SO - Sci Rep. 2023 Jul 18;13(1):11564. doi: 10.1038/s41598-023-38813-3. PMID- 18354967 OWN - NLM STAT- MEDLINE DCOM- 20080424 LR - 20170214 IS - 0018-7208 (Print) IS - 0018-7208 (Linking) VI - 50 IP - 1 DP - 2008 Feb TI - Articulating the differences between safety and resilience: the decision-making process of professional sea-fishing skippers. PG - 1-16 AB - OBJECTIVE: As the world's most dangerous profession, sea fishing enables discussion of the concept of resilience and its articulation to the notion of safety in complex systems. BACKGROUND: In the small, emerging community working on this concept, the prevailing idea to improve safety is that resilience must be reinjected into the know-how of complex systems. METHOD: Thirty-four male skippers, divided into two groups, took part in an interactive simulation of a fishing campaign. They had to make decisions in situations of trade-off between safety and production goals. RESULTS: From the time they left the harbor, the fishermen never gave up on fishing, even in extreme conditions, and regardless of whether or not the catch was good. Not being suicidal, however, they used multiple expert strategies to reduce risk without giving up on their fishing activity. CONCLUSION: Systems run by craftspeople are very resilient because they rely on a high level of adaptability, based on the actors' expertise, linked to an exposure to frequent and considerable risk. Each actor is responsible for his or her own safety. The final discussion bears on the question of knowing whether or not it is possible to design a safe system while preserving its craftsmanship and therefore its native resilience. APPLICATION: The results of these studies suggest potential adverse effects of classic safety interventions in complex sociotechnical systems either in terms of professional reluctance to accept new recommendations or through the emergence of new sources of risk. FAU - Mörel, Gaël AU - Mörel G AD - Study Group on Health, Work, Information and Cognition, University of South Brittany, Centre de Recherche, Rue Saint Maudé, Lorient 56325, France. gmorel@univ-ubs.fr FAU - Amalberti, René AU - Amalberti R FAU - Chauvin, Christine AU - Chauvin C LA - eng PT - Journal Article PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - *Decision Making MH - Fisheries MH - France MH - Humans MH - Male MH - *Occupational Health MH - *Ships EDAT- 2008/03/22 09:00 MHDA- 2008/04/25 09:00 CRDT- 2008/03/22 09:00 PHST- 2008/03/22 09:00 [pubmed] PHST- 2008/04/25 09:00 [medline] PHST- 2008/03/22 09:00 [entrez] AID - 10.1518/001872008X250683 [doi] PST - ppublish SO - Hum Factors. 2008 Feb;50(1):1-16. doi: 10.1518/001872008X250683. PMID- 35638940 OWN - NLM STAT- MEDLINE DCOM- 20220719 LR - 20220819 IS - 1742-6723 (Electronic) IS - 1742-6723 (Linking) VI - 34 IP - 4 DP - 2022 Aug TI - Use of clonidine in the treatment of Irukandji syndrome: A 4-year retrospective cohort study on safety, efficacy and clinical utility. PG - 504-508 LID - 10.1111/1742-6723.14017 [doi] AB - OBJECTIVE: Irukandji syndrome (IS) is an extremely painful condition that causes a significant catecholamine surge and sympathetic autonomic response related to the envenomation from certain types of jellyfish. Current management involves intravenous fluids, magnesium sulphate and large doses of opioids for symptom control. Clonidine, a centrally acting alpha-2 agonist, is often used as an analgesic adjunct to reduce opioid requirements in acute pain. The present study explores the safety and efficacy of clonidine in reducing opioid requirements in IS. METHODS: All patients diagnosed with IS at Cairns Hospital between 1 March 2016 and 30 April 2020, and participants from the Magnesium in Irukandji Study Trial, were included in this retrospective study (n = 114). Cases were separated into two groups depending on whether or not they received clonidine, and subsequently analysed according to pre- and post-intervention opioid requirements, clonidine dose administered and adverse effects. RESULTS: Notably, 39 patients with IS received ≥1 mcg/kg clonidine and the remaining 75 did not. There was no difference in oral morphine equivalent daily dose (oMEDD) between groups before clonidine administration; however, there was a significant reduction in oMEDD required after patients received clonidine (26.1 mg; 95% CI 4.6-47.7) compared with those who did not (66.6 mg; 95% CI 56.9-86.1) (F = 8.722, df = 1 × 224, P = 0.003). One episode of hypotension occurred following the intervention. CONCLUSION: Patients with IS who received clonidine required significantly lower opioid requirements than those who did not receive clonidine. Clonidine was safe to administer and should be considered early when treating IS. The optimal clonidine dose remains unclear and requires prospective studies to validate our findings. CI - © 2022 Australasian College for Emergency Medicine. FAU - Isman, Ari AU - Isman A AUID- ORCID: 0000-0001-9495-4283 AD - Faculty of Medicine, James Cook University, Cairns, Queensland, Australia. AD - Emergency Department, Cairns Hospital, Cairns, Queensland, Australia. FAU - Seymour, Jamie AU - Seymour J AD - Faculty of Medicine, Health and Molecular Sciences, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia. FAU - Little, Mark AU - Little M AUID- ORCID: 0000-0001-7318-3758 AD - Emergency Department, Cairns Hospital, Cairns, Queensland, Australia. LA - eng PT - Journal Article DEP - 20220531 PL - Australia TA - Emerg Med Australas JT - Emergency medicine Australasia : EMA JID - 101199824 RN - 0 (Analgesics) RN - 0 (Analgesics, Opioid) RN - 0 (Cnidarian Venoms) RN - MN3L5RMN02 (Clonidine) SB - IM CIN - Emerg Med Australas. 2022 Aug;34(4):482-483. doi: 10.1111/1742-6723.14025. PMID: 35843606 MH - *Analgesics/therapeutic use MH - *Analgesics, Opioid/adverse effects MH - *Bites and Stings/diagnosis/drug therapy MH - *Clonidine/adverse effects MH - *Cnidarian Venoms MH - Humans MH - Retrospective Studies MH - Syndrome OTO - NOTNLM OT - Irukandji syndome OT - clonidine OT - jellyfish sting OT - marine envenomation OT - pain EDAT- 2022/06/01 06:00 MHDA- 2022/07/20 06:00 CRDT- 2022/05/31 15:23 PHST- 2022/04/19 00:00 [revised] PHST- 2021/05/23 00:00 [received] PHST- 2022/05/01 00:00 [accepted] PHST- 2022/06/01 06:00 [pubmed] PHST- 2022/07/20 06:00 [medline] PHST- 2022/05/31 15:23 [entrez] AID - 10.1111/1742-6723.14017 [doi] PST - ppublish SO - Emerg Med Australas. 2022 Aug;34(4):504-508. doi: 10.1111/1742-6723.14017. Epub 2022 May 31. PMID- 38153580 OWN - NLM STAT- MEDLINE DCOM- 20240131 LR - 20240706 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 31 IP - 5 DP - 2024 Jan TI - Experimental study on overtopping dam-break of a tailing reservoir under extreme conditions. PG - 6874-6890 LID - 10.1007/s11356-023-31711-1 [doi] AB - There is a high risk of dam breakage in tailing reservoirs under extreme conditions. Once a dam breaks, it causes serious pollution to the surrounding ecological environment. To explore the effects of a tailings dam break under extreme conditions (flood conditions, drainage failure, flood discharge failure, and dam saturation), the mechanism underlying an overtopping dam break must be accurately understood. In this study, fine-grained tailings and perlite were selected to create composite model sand, and a prototype tailing reservoir was restored at a scale of 1:200. Furthermore, the dam-break process and results were analyzed and summarized by performing an overtopping dam-break test on the tailing reservoir under extreme conditions. The results show that the tailing discharge process has a high sand content, strong sand-carrying capacity, and high speed. The amount of model sand discharge accounted for 15.13% of the total storage capacity, and the amount of tailings deposition in the downstream area accounted for 95.21% of the discharge, which were both greater than the results of similar physical model tests and actual tailings dam failure accidents. An overtopping dam break in a tailing pond is a progressively destructive process. The dam break mechanism can be divided into two stages: prior breach penetration and subsequent breach horizontal expansion. In the process of a tailings dam break, the motion state of the tailings particles is transformed between the bed-load and suspended-load movement states. These results can provide important reference for the reinforcement of mine management and the formulation of preventive measures, which are essential to improving the safety of tailings reservoirs and protecting the ecological environment. CI - © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Du, Changbo AU - Du C AD - College of Civil Engineering, Liaoning Technical University, Fuxin, 123000, China. FAU - Tao, Han AU - Tao H AUID- ORCID: 0000-0002-0616-428X AD - College of Civil Engineering, Liaoning Technical University, Fuxin, 123000, China. thfun1998@163.com. FAU - Yi, Fu AU - Yi F AD - College of Civil Engineering, Liaoning Technical University, Fuxin, 123000, China. AD - Beijing Jingneng Geological Engineering Co., Ltd., Beijing, 100000, China. FAU - Cheng, Chuanwang AU - Cheng C AD - College of Civil Engineering, Liaoning Technical University, Fuxin, 123000, China. LA - eng GR - LJKQZ2021153/The youth fund of Liaoning Provincial Department of Education/ GR - LJ2020JCL037/Liaoning Provincial Department of Education Scientific Research General Project/ GR - LNTU20TD-12/The discipline innovation team of Liaoning Technical University/ PT - Journal Article DEP - 20231228 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Sand) SB - IM MH - *Sand MH - *Environmental Pollution MH - Floods MH - Accidents MH - Conservation of Natural Resources OTO - NOTNLM OT - Dam-break mechanism OT - Extreme conditions OT - Overtopping dam break OT - Physical model test OT - Tailings reservoir EDAT- 2023/12/28 12:42 MHDA- 2024/01/31 06:42 CRDT- 2023/12/28 11:20 PHST- 2023/10/16 00:00 [received] PHST- 2023/12/20 00:00 [accepted] PHST- 2024/01/31 06:42 [medline] PHST- 2023/12/28 12:42 [pubmed] PHST- 2023/12/28 11:20 [entrez] AID - 10.1007/s11356-023-31711-1 [pii] AID - 10.1007/s11356-023-31711-1 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2024 Jan;31(5):6874-6890. doi: 10.1007/s11356-023-31711-1. Epub 2023 Dec 28. PMID- 38013921 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231129 IS - 2353-561X (Electronic) IS - 2353-4192 (Print) IS - 2353-561X (Linking) VI - 10 IP - 2 DP - 2022 TI - The model of psychological safety of a soldier's personality. PG - 112-122 LID - 10.5114/cipp.2021.108684 [doi] AB - BACKGROUND: From 2014 to the present, Ukrainian military personnel have been fighting in Eastern Ukraine against illegal armed formations of separatists. The resulting combat stress negatively affects servicemen's mental health status. This study aimed to examine the factor structure of a scale to assess the psychological safety of a soldier's personality (PSSP), taking into account changes in the conditions of military service to improve the professional and psychological training of military personnel. PARTICIPANTS AND PROCEDURE: The study involved 118 officers of the National Guard of Ukraine. The semantic differential method, expert judgment, and exploratory factor analysis were used to determine the factor structure of the PSSP. RESULTS: The PSSP model to maintain combat readiness in daily activities includes four components: "Moral and communicative", "Motivational and volitional", "Value and meaning of life" and "Inner comfort". For activities in extreme conditions (during combat deployment), the personality potential of four structural components is used: "Moral and volitional regulation", "Coping strategies", "Value and meaning of life" and "Post-traumatic growth/regression". CONCLUSIONS: The PSSP model consists of four components that have different content depending on the conditions for performance of professional tasks by military personnel. It is advisable to use the obtained results of the content of the PSSP model in the development of professional and psychological training programs for the purposeful formation of the resilience of military personnel, taking into account the conditions of their activities. CI - Copyright © Institute of Psychology, University of Gdansk. FAU - Prykhodko, Ihor AU - Prykhodko I AUID- ORCID: 0000-0002-4484-9781 AD - National Academy of the National Guard of Ukraine, Kharkiv, Ukraine. LA - eng PT - Journal Article DEP - 20210921 PL - Poland TA - Curr Issues Personal Psychol JT - Current issues in personality psychology JID - 101694413 PMC - PMC10653560 OTO - NOTNLM OT - combat readiness OT - extreme conditions OT - military personnel OT - military service OT - security EDAT- 2021/09/21 00:00 MHDA- 2021/09/21 00:01 PMCR- 2021/09/21 CRDT- 2023/11/28 03:56 PHST- 2021/03/14 00:00 [received] PHST- 2021/04/15 00:00 [revised] PHST- 2021/07/25 00:00 [accepted] PHST- 2021/09/21 00:01 [medline] PHST- 2021/09/21 00:00 [pubmed] PHST- 2023/11/28 03:56 [entrez] PHST- 2021/09/21 00:00 [pmc-release] AID - 140500 [pii] AID - 10.5114/cipp.2021.108684 [doi] PST - epublish SO - Curr Issues Personal Psychol. 2021 Sep 21;10(2):112-122. doi: 10.5114/cipp.2021.108684. eCollection 2022. PMID- 27261563 OWN - NLM STAT- MEDLINE DCOM- 20180108 LR - 20180820 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) VI - 28 IP - 5 DP - 2016 Oct TI - Attention deficit hyperactivity disorder medications in children with heart disease. PG - 607-12 LID - 10.1097/MOP.0000000000000388 [doi] AB - PURPOSE OF REVIEW: Attention deficit hyperactivity disorder (ADHD) is quite common in the general pediatric population, Its incidence is thought to be even higher in the population of patients with congenital heart disease, especially in those patients with complex disease and who have had cardiac surgical interventions early in life. There has been controversy as to the safety of ADHD medications, especially in the latter population of patients. This compendium is meant to review the effects of the ADHD medications and the safety of these medications in patients with either known or undiagnosed congenital heart disease. RECENT FINDINGS: The concern with regard to the use of ADHD medications has been as a result of the reports of sudden unexpected deaths among patients taking stimulant drugs for ADHD. Therefore, the question of whether or not stimulant drugs increase the risk of adverse cardiovascular events has led to a discussion of the appropriate use of these drugs in patients with known cardiovascular disease, as well as a discussion as to the appropriate evaluation in order to identify undiagnosed 'at-risk' patients with congenital heart disease or arrhythmias. This article will review and amplify these discussions, as well as the conclusions that have come forth as a result of these discussions. SUMMARY: Currently available data suggest that there is no evidence for serious adverse cardiovascular complications in children with known cardiovascular diseases including patients of congenital heart disease who are treated with stimulant medications. Despite this, if the patient does have known cardiac disease, or if the history and physical examination is suggestive of cardiac disease, it is suggested that consultation/evaluation with a pediatric cardiologist occur. It is extremely unlikely that stimulant medications would be contraindicated in almost any condition that falls under this category. However, a few specific cardiac conditions might tailor the choice of the specific ADHD medication. Therefore the coordination of care between the primary care physician, the ADHD medication-prescribing physician, and the pediatric cardiologist may be very important in this circumstance. FAU - Berger, Stuart AU - Berger S AD - University of California - Davis, Sacramento, California, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 RN - 0 (Central Nervous System Stimulants) SB - IM MH - Attention Deficit Disorder with Hyperactivity/complications/*drug therapy MH - Cardiovascular Diseases/chemically induced/prevention & control MH - Central Nervous System Stimulants/*adverse effects/therapeutic use MH - Child MH - Death, Sudden, Cardiac/etiology/prevention & control MH - Electrocardiography MH - Heart Defects, Congenital/*complications MH - Humans EDAT- 2016/06/05 06:00 MHDA- 2018/01/09 06:00 CRDT- 2016/06/05 06:00 PHST- 2016/06/05 06:00 [entrez] PHST- 2016/06/05 06:00 [pubmed] PHST- 2018/01/09 06:00 [medline] AID - 10.1097/MOP.0000000000000388 [doi] PST - ppublish SO - Curr Opin Pediatr. 2016 Oct;28(5):607-12. doi: 10.1097/MOP.0000000000000388. PMID- 35136655 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220501 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 8 IP - 1 DP - 2022 TI - Common health issues and advised treatments reported in an ultraendurance ocean rowing race. PG - e001120 LID - 10.1136/bmjsem-2021-001120 [doi] LID - e001120 AB - OBJECTIVES: Ocean rowing is an extreme ultraendurance sport where individuals row unsupported across an ocean. This can mean months at sea in unpredictable and inhospitable conditions. The extreme physical and mental demands associated mean medical issues are common yet under researched, impacting the medical assistance provided. METHODS: The Talisker Whisky Atlantic Challenge provides a framework with safety protocols to create safer environments for athletes to attempt transatlantic crossings. Race logs, which record communication between rowers and safety teams, were anonymised and examined to create cumulative totals of medical issues requiring help and an incident timeline. RESULTS: Duty officers were notified of 65 medical complaints, 32% (n=21) requiring race doctors. Dermatological conditions were most common, accounting for 32% of complaints (n=21) and affecting 24% of rowers. Pressure sores and infections represented 43% and 38% of dermatological complaints respectively. Musculoskeletal injuries equalled 18% (n=12) of complaints, affecting 20% of rowers. Most cases were reported in weeks one and three, with 37% (n=24) of issues and 90% (n=10) of seasickness cases in week one. Hygiene and antibiotics were frequently advised management options. CONCLUSION: Conditions requiring race doctor input represent the most severe cases with the potential to deteriorate. Managing dermatological and musculoskeletal issues is vital throughout the race, while seasickness prophylaxis and education is essential in initial race stages. Infections are cause for concern, with gluteal pressure sores a potential route for secondary infections. Further research is required before evidence-based guidelines for management of health issues in ocean rowers can be introduced. CI - © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Galsworthy, William J H AU - Galsworthy WJH AD - GKT School of Medical Education, King's College London, London, UK. FAU - Carr, James A J AU - Carr JAJ AD - GKT School of Medical Education, King's College London, London, UK. FAU - Hearn, Russell AU - Hearn R AUID- ORCID: 0000-0002-6909-7395 AD - School of Life Course and Population Science, King's College London, London, UK. LA - eng PT - Journal Article DEP - 20220128 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC8804690 OTO - NOTNLM OT - dermatology OT - endurance OT - injuries OT - outdoor medicine OT - rowing COIS- Competing interests: None declared. EDAT- 2022/02/10 06:00 MHDA- 2022/02/10 06:01 PMCR- 2022/01/28 CRDT- 2022/02/09 05:53 PHST- 2021/11/09 00:00 [accepted] PHST- 2022/02/09 05:53 [entrez] PHST- 2022/02/10 06:00 [pubmed] PHST- 2022/02/10 06:01 [medline] PHST- 2022/01/28 00:00 [pmc-release] AID - bmjsem-2021-001120 [pii] AID - 10.1136/bmjsem-2021-001120 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2022 Jan 28;8(1):e001120. doi: 10.1136/bmjsem-2021-001120. eCollection 2022. PMID- 38607726 OWN - NLM STAT- MEDLINE DCOM- 20241105 LR - 20241105 IS - 1930-613X (Electronic) IS - 0026-4075 (Linking) VI - 189 IP - 11-12 DP - 2024 Nov 5 TI - Reappraising the Use of Systemic Immunomodulators for Psoriasis and Eczema in the Military. PG - e2374-e2381 LID - 10.1093/milmed/usae139 [doi] AB - INTRODUCTION: Psoriasis and atopic dermatitis are chronic, immune-mediated skin disorders that are disqualifying for entrance into the military. Both conditions can cause difficulty wearing body armor and other protective equipment when poorly controlled, limiting a service member's ability to train and deploy worldwide. In addition, these conditions may be exacerbated by military service because of increased exposure to austere environments, extreme temperatures, stress, skin injury, bug bites, and vaccinations Service members have limited treatment options because of restrictions on systemic medications that can be used while deployed. Newer systemic medications-in particular, biologics and oral immunomodulators-have evolved to be both extremely effective and safe. We review more recent treatment options for psoriasis and atopic dermatitis in the context of DoD's regulations guiding entry and retention of personnel with psoriasis and eczema and make recommendations regarding updating DoD policy for systemic treatment options. MATERIALS AND METHODS: A literature search was performed using PubMed, Embase, and Ovid with the last search done in the fall of 2023 from all years to date. These articles were further screened based on inclusion and exclusion criteria. In total, 25 articles were included in this review. An Internet search was also performed on the DoD's regulations guiding entry and retention of personnel with psoriasis and eczema. In addition, we examined medical requirements for deployment to the U.S. Central Command and U.S. European Command. RESULTS: Currently, U.S. Central Command and U.S. European Command do not allow the use of medications with special storage and handling requirements on deployments. Newer biologics are safe and efficacious but require refrigeration, although other immunomodulators like deucravacitinib and apremilast are oral pills and do not have cold-storage requirements. However, the use of biologics in austere environments may be feasible because of increased intervals between dosing and the ability to store refrigerated medical supplies in most deployed environments. For military service members with psoriasis, risankizumab and deucravacitinib are excellent options given their favorable safety and efficacy profiles. Of the biologics available for atopic dermatitis, dupilumab is the safest and effective systemic medication available. The Janus kinase inhibitors have also demonstrated excellent efficacy in treating atopic dermatitis, but more safety data are needed because of potential adverse events to include heart-related events, blood clots, and cancers. CONCLUSIONS: Systemic treatments have evolved to become highly specific for both eczema and psoriasis. These newer biologics and immunomodulators may be compatible with use in the deployed setting, especially those that have long dosing intervals and proven efficacy and safety. Of the biologics, dupilumab and risankizumab offer the best efficacy, safety, and dosing intervals for atopic dermatitis and psoriasis, respectively. Deucravcitinib is a recently FDA-approved oral immunomodulator for psoriasis that has an excellent safety profile and efficacy. Allowing the use of these medications on deployments will enable more people with moderate to severe psoriasis and eczema to join and remain in the military while receiving effective treatment. CI - Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2024. This work is written by (a) US Government employee(s) and is in the public domain in the US. FAU - Russell, Alexius AU - Russell A AUID- ORCID: 0009-0009-0220-7121 AD - School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. FAU - Williamson, Samantha AU - Williamson S AD - School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. FAU - Rosenberg, Alexandra AU - Rosenberg A AD - Department of Dermatology, William Beaumont Army Medical Center, El Paso, TX 48073, USA. FAU - Cho, Sunghun AU - Cho S AD - Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA. LA - eng PT - Journal Article PT - Review PL - England TA - Mil Med JT - Military medicine JID - 2984771R RN - 0 (Immunologic Factors) RN - 0 (Immunomodulating Agents) SB - IM MH - Humans MH - *Psoriasis/drug therapy MH - *Military Personnel/statistics & numerical data MH - *Eczema/drug therapy MH - *Immunologic Factors/therapeutic use MH - Immunomodulating Agents/therapeutic use EDAT- 2024/04/12 18:42 MHDA- 2024/11/05 17:02 CRDT- 2024/04/12 12:23 PHST- 2023/11/22 00:00 [received] PHST- 2024/02/21 00:00 [revised] PHST- 2024/03/13 00:00 [accepted] PHST- 2024/11/05 17:02 [medline] PHST- 2024/04/12 18:42 [pubmed] PHST- 2024/04/12 12:23 [entrez] AID - 7644863 [pii] AID - 10.1093/milmed/usae139 [doi] PST - ppublish SO - Mil Med. 2024 Nov 5;189(11-12):e2374-e2381. doi: 10.1093/milmed/usae139. PMID- 18810199 OWN - NLM STAT- MEDLINE DCOM- 20090113 LR - 20190710 IS - 0079-6492 (Print) IS - 0079-6492 (Linking) VI - 21 DP - 2008 TI - Radiosurgery: operative technique, pitfalls and tips. PG - 54-64 LID - 10.1159/000156594 [doi] AB - RATIONALE: From frame placement to dose administration, each step of the procedure must be optimized in every detail for better preservation of global precision, accuracy, safety and efficacy. METHODS: Quality control for resolution, accuracy and acquisition parameter optimization of both computed tomography (CT) scanners and magnetic resonance imaging (MRI) must be performed. Inaccuracies should then be quantified through systematic combination of MRI and CT in the radiosurgery planning system. Topography of petrous structures such as cochlea, vestibulum and facial nerve canal should be visible on the CT scan. T1-weighted volumetric MRI pulse sequences (3DT1) show a contrast-enhanced signal that is useful for both the pons interface delineation in Koos III cases, and the canal ending. High-resolution CISS T2-weighted volumetric pulse sequences (3DT2) allow direct nerve visualization and give superior stereotactic definition attributable to their better resolution minimizing partial volume effects and to their lower magnetic susceptibility minimizing distortions. The 3DT2 pulse sequences with contrast injection, show improved distinction between the pons and the nerves due to signal differences within the schwannomas. Fat saturation pulse sequences are of interest in postmicrosurgery conditions. The previous technical requirements and the dose planning elaboration will be balanced depending on the lesion volume staging (Koos), treatment history (microsurgery), clinical condition (hearing quality), pathological context (NF2) or age of the patient. The recommended marginal dose is 11-12 Gy. Tumor volume delineation allows the calculation of conformity, selectivity and gradient indexes. These global indexes must be weighted according to the relationship to critical structures and functional status of the patient. CONCLUSIONS: As an exclusively image-guided surgical method, radiosurgery requires special attention in the choice of imaging modalities and their acquisition parameters need extreme care. Technical nuances during the elaboration of the dose planning itself will directly influence both the toxicity risk and the chance of cure. FAU - Régis, Jean AU - Régis J AD - Service de Neurochirurgie Fonctionnelle et Stéréotaxique, Hôpital d'Adulte de la Timone, Marseille, France. FAU - Tamura, Manabu AU - Tamura M FAU - Wikler, David AU - Wikler D FAU - Porcheron, Denis AU - Porcheron D FAU - Levrier, Olivier AU - Levrier O LA - eng PT - Journal Article PT - Review PL - Switzerland TA - Prog Neurol Surg JT - Progress in neurological surgery JID - 0076033 SB - IM MH - Humans MH - Magnetic Resonance Imaging MH - Neuroma, Acoustic/diagnostic imaging/pathology/*surgery MH - Quality Control MH - Radiosurgery/*adverse effects/*methods MH - Radiotherapy Dosage MH - Radiotherapy Planning, Computer-Assisted MH - Tomography, X-Ray Computed RF - 22 EDAT- 2008/09/24 09:00 MHDA- 2009/01/14 09:00 CRDT- 2008/09/24 09:00 PHST- 2008/09/24 09:00 [pubmed] PHST- 2009/01/14 09:00 [medline] PHST- 2008/09/24 09:00 [entrez] AID - 000156594 [pii] AID - 10.1159/000156594 [doi] PST - ppublish SO - Prog Neurol Surg. 2008;21:54-64. doi: 10.1159/000156594. PMID- 25987259 OWN - NLM STAT- MEDLINE DCOM- 20151229 LR - 20150926 IS - 1523-6838 (Electronic) IS - 0272-6386 (Linking) VI - 66 IP - 4 DP - 2015 Oct TI - Dialysate Sodium: Choosing the Optimal Hemodialysis Bath. PG - 710-20 LID - S0272-6386(15)00630-7 [pii] LID - 10.1053/j.ajkd.2015.03.034 [doi] AB - Fluid overload in patients undergoing hemodialysis contributes to cardiovascular morbidity and is a major cause of hospitalizations. It is often addressed by reinforcing the importance of a low-salt diet with patients and challenging estimated dry weights. More recently, interest has shifted toward the dialysate sodium prescription as a strategy to improve fluid overload and its adverse sequelae. The availability of high-flux high-efficiency dialysis in conjunction with the need to ensure its tolerability for patients has resulted in an increase in dialysate sodium prescriptions from 120 to ≥140 mEq/L. However, we are now tackling the unforeseen consequences associated with high dialysate sodium prescriptions. High dialysate sodium concentration is associated with high interdialytic weight gain, a commonly used surrogate for hypervolemia contributing to hypertension. The association between mortality and high dialysate sodium concentration remains controversial with conflicting data. It is clear that fluid management in the diverse end-stage renal disease population is extremely complex and more clinical trials are needed. In the meantime, while patients require treatments and clinical decisions need to be made, this review article attempts to summarize the current evidence for individualized dialysate sodium prescriptions based on patients' volume status, comorbid conditions, plasma sodium level, and hemodynamic response to dialysis therapy. CI - Copyright © 2015 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. FAU - Munoz Mendoza, Jair AU - Munoz Mendoza J AD - Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, FL. FAU - Arramreddy, Rohini AU - Arramreddy R AD - Satellite Healthcare, San Jose, CA; Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA. FAU - Schiller, Brigitte AU - Schiller B AD - Satellite Healthcare, San Jose, CA; Department of Medicine, Division of Nephrology, Stanford University, Palo Alto, CA. Electronic address: schillerb@satellitehealth.com. LA - eng PT - Journal Article PT - Review DEP - 20150516 PL - United States TA - Am J Kidney Dis JT - American journal of kidney diseases : the official journal of the National Kidney Foundation JID - 8110075 RN - 0 (Hemodialysis Solutions) RN - 9NEZ333N27 (Sodium) SB - IM MH - Diet, Sodium-Restricted MH - Female MH - Hemodialysis Solutions/adverse effects/*chemistry MH - Humans MH - Kidney Failure, Chronic/blood/mortality/*therapy MH - Male MH - Patient Safety MH - Renal Dialysis/*adverse effects/methods/mortality MH - Risk Assessment MH - Sodium/blood/*metabolism MH - Survival Analysis MH - Water Intoxication/etiology/prevention & control MH - Water-Electrolyte Imbalance/etiology/*prevention & control OTO - NOTNLM OT - Dialysate sodium OT - dry weight OT - fluid overload OT - hemodialysis OT - inter-dialytic weight gain OT - intra-dialytic hypotension OT - review OT - sodium gradient OT - target weight EDAT- 2015/05/20 06:00 MHDA- 2015/12/30 06:00 CRDT- 2015/05/20 06:00 PHST- 2014/11/22 00:00 [received] PHST- 2015/03/20 00:00 [accepted] PHST- 2015/05/20 06:00 [entrez] PHST- 2015/05/20 06:00 [pubmed] PHST- 2015/12/30 06:00 [medline] AID - S0272-6386(15)00630-7 [pii] AID - 10.1053/j.ajkd.2015.03.034 [doi] PST - ppublish SO - Am J Kidney Dis. 2015 Oct;66(4):710-20. doi: 10.1053/j.ajkd.2015.03.034. Epub 2015 May 16. PMID- 31596615 OWN - NLM STAT- MEDLINE DCOM- 20220310 LR - 20220531 IS - 1547-8181 (Electronic) IS - 0018-7208 (Linking) VI - 63 IP - 2 DP - 2021 Mar TI - Physical Exercise Intensity During Submersion Selectively Affects Executive Functions. PG - 227-239 LID - 10.1177/0018720819879313 [doi] AB - OBJECTIVE: The intact cognitive processing capacity in highly demanding and dynamically changing situations (e.g., in extreme environmental conditions) is of central relevance for personal safety. This study therefore investigated whether underwater physical exercise (PE) affected cognitive performance by comparing these effects during underwater fin-swimming as opposed to inactivity under normal environmental conditions. BACKGROUND: Although acute bouts of PE can modulate cognitive performance under highly controlled and standardized laboratory conditions, no previous study has determined whether PE acutely modulates cognitive performance in non-laboratory testing conditions involving extreme environments (e.g., underwater). METHOD: A total of 27 healthy volunteers (16 males and 11 females; 28.9 ± 7.4 years of age) participated in two experiments involving either moderate or high PE intensity. A PRE/POST crossover design was employed among participants while performing cognitive tests in a counterbalanced order (i.e., before and after 20 min of PE in submersion [WET] and once before and after inactivity [DRY] while in the laboratory). Cognitive performance was measured as a combination of executive functions through the Eriksen Flanker (inhibition) and Two-Back (working memory) Tasks using an underwater tablet computer. RESULTS: ANOVAs revealed enhanced reaction times only in the Flanker test after moderate PE for the WET condition. No other effects were detected. CONCLUSION: These findings indicate that cognitive performance is exercise-intensity-dependent with enhanced effects during moderate PE, even in extreme environments (i.e., underwater). APPLICATION: These results should be relevant in recreational and occupational contexts involving underwater activity and may also apply to microgravity (e.g., during extra-vehicular activities). DESCRIPTION: This study compared the acute effects of physical exercise (PE) on cognitive performance in an underwater environment while participants fin-swam with SCUBA (self-contained underwater breathing apparatus) gear. Findings revealed that 20 min of moderate PE positively affected cognitive performance (i.e., inhibitory control ability). However, no changes were observed after high-intensity exercise. FAU - Möller, Fabian AU - Möller F AUID- ORCID: 0000-0001-5664-8111 FAU - Hoffmann, Uwe AU - Hoffmann U AD - German Sport University Cologne, Germany. FAU - Dalecki, Marc AU - Dalecki M AD - Louisiana State University, Baton Rouge, USA. FAU - Dräger, Tobias AU - Dräger T AD - Diving Consultant Group, Cologne, Germany. FAU - Doppelmayr, Michael AU - Doppelmayr M FAU - Steinberg, Fabian AU - Steinberg F AD - Johannes Gutenberg-University Mainz, Germany. LA - eng PT - Journal Article DEP - 20191009 PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - Adult MH - Cognition MH - Cross-Over Studies MH - *Executive Function MH - Female MH - Humans MH - *Immersion MH - Male MH - Memory, Short-Term MH - Neuropsychological Tests MH - Swimming/physiology OTO - NOTNLM OT - SCUBA OT - cognition OT - diving OT - executive functions OT - microgravity OT - space safety EDAT- 2019/10/10 06:00 MHDA- 2022/03/11 06:00 CRDT- 2019/10/10 06:00 PHST- 2019/10/10 06:00 [pubmed] PHST- 2022/03/11 06:00 [medline] PHST- 2019/10/10 06:00 [entrez] AID - 10.1177/0018720819879313 [doi] PST - ppublish SO - Hum Factors. 2021 Mar;63(2):227-239. doi: 10.1177/0018720819879313. Epub 2019 Oct 9. PMID- 26676093 OWN - NLM STAT- MEDLINE DCOM- 20160428 LR - 20240708 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2015 IP - 12 DP - 2015 Dec 16 TI - Trocar types in laparoscopy. PG - CD009814 LID - 10.1002/14651858.CD009814.pub2 [doi] LID - CD009814 AB - BACKGROUND: Laparoscopic surgery has led to great clinical improvements in many fields of surgery; however, it requires the use of trocars, which may lead to complications as well as postoperative pain. The complications include intra-abdominal vascular and visceral injury, trocar site bleeding, herniation and infection. Many of these are extremely rare, such as vascular and visceral injury, but may be life-threatening; therefore, it is important to determine how these types of complications may be prevented. It is hypothesised that trocar-related complications and pain may be attributable to certain types of trocars. This systematic review was designed to improve patient safety by determining which, if any, specific trocar types are less likely to result in complications and postoperative pain. OBJECTIVES: To analyse the rates of trocar-related complications and postoperative pain for different trocar types used in people undergoing laparoscopy, regardless of the condition. SEARCH METHODS: Two experienced librarians conducted a comprehensive search for randomised controlled trials (RCTs) in the Menstrual Disorders and Subfertility Group Specialised Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, PsycINFO, CINAHL, CDSR and DARE (up to 26 May 2015). We checked trial registers and reference lists from trial and review articles, and approached content experts. SELECTION CRITERIA: RCTs that compared rates of trocar-related complications and postoperative pain for different trocar types used in people undergoing laparoscopy. The primary outcomes were major trocar-related complications, such as mortality, conversion due to any trocar-related adverse event, visceral injury, vascular injury and other injuries that required intensive care unit (ICU) management or a subsequent surgical, endoscopic or radiological intervention. Secondary outcomes were minor trocar-related complications and postoperative pain. We excluded trials that studied non-conventional laparoscopic incisions. DATA COLLECTION AND ANALYSIS: Two review authors independently conducted the study selection, risk of bias assessment and data extraction. We used GRADE to assess the overall quality of the evidence. We performed sensitivity analyses and investigation of heterogeneity, where possible. MAIN RESULTS: We included seven RCTs (654 participants). One RCT studied four different trocar types, while the remaining six RCTs studied two different types. The following trocar types were examined: radially expanding versus cutting (six studies; 604 participants), conical blunt-tipped versus cutting (two studies; 72 participants), radially expanding versus conical blunt-tipped (one study; 28 participants) and single-bladed versus pyramidal-bladed (one study; 28 participants). The evidence was very low quality: limitations were insufficient power, very serious imprecision and incomplete outcome data. Primary outcomesFour of the included studies reported on visceral and vascular injury (571 participants), which are two of our primary outcomes. These RCTs examined 473 participants where radially expanding versus cutting trocars were used. We found no evidence of a difference in the incidence of visceral (Peto odds ratio (OR) 0.95, 95% confidence interval (CI) 0.06 to 15.32) and vascular injury (Peto OR 0.14, 95% CI 0.0 to 7.16), both very low quality evidence. However, the incidence of these types of injuries were extremely low (i.e. two cases of visceral and one case of vascular injury for all of the included studies). There were no cases of either visceral or vascular injury for any of the other trocar type comparisons. No studies reported on any other primary outcomes, such as mortality, conversion to laparotomy, intensive care admission or any re-intervention. Secondary outcomesFor trocar site bleeding, the use of radially expanding trocars was associated with a lower risk of trocar site bleeding compared to cutting trocars (Peto OR 0.28, 95% CI 0.14 to 0.54, five studies, 553 participants, very low quality evidence). This suggests that if the risk of trocar site bleeding with the use of cutting trocars is assumed to be 11.5%, the risk with the use of radially expanding trocars would be 3.5%. There was insufficient evidence to reach a conclusion regarding other trocar types, their related complications and postoperative pain, as no studies reported data suitable for analysis. AUTHORS' CONCLUSIONS: Data were lacking on the incidence of major trocar-related complications, such as visceral or vascular injury, when comparing different trocar types with one another. However, caution is urged when interpreting these results because the incidence of serious complications following the use of a trocar was extremely low. There was very low quality evidence for minor trocar-related complications suggesting that the use of radially expanding trocars compared to cutting trocars leads to reduced incidence of trocar site bleeding. These secondary outcomes are viewed to be of less clinical importance.Large, well-conducted observational studies are necessary to answer the questions addressed in this review because serious complications, such as visceral or vascular injury, are extremely rare. However, for other outcomes, such as trocar site herniation, bleeding or infection, large observational studies may be needed as well. In order to answer these questions, it is advisable to establish an international network for recording these types of complications following laparoscopic surgery. FAU - la Chapelle, Claire F AU - la Chapelle CF AD - Leiden University Medical Centre, K6-76, Albinusdreef 2, Leiden, 2333 ZA, Netherlands. FAU - Swank, Hilko A AU - Swank HA FAU - Wessels, Monique E AU - Wessels ME FAU - Mol, Ben Willem J AU - Mol BW FAU - Rubinstein, Sidney M AU - Rubinstein SM FAU - Jansen, Frank Willem AU - Jansen FW LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20151216 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - doi: 10.1002/14651858.CD009814 MH - Abdominal Injuries/etiology MH - Equipment Design/adverse effects MH - Hernia, Abdominal/etiology MH - Humans MH - Laparoscopy/adverse effects/*instrumentation MH - Pain, Postoperative/prevention & control MH - *Patient Safety MH - Randomized Controlled Trials as Topic MH - Surgical Instruments/*adverse effects MH - Vascular System Injuries/*etiology MH - Viscera/*injuries PMC - PMC11227320 COIS- The authors do not have any potential conflicts of interest. EDAT- 2015/12/18 06:00 MHDA- 2016/04/29 06:00 PMCR- 2016/12/16 CRDT- 2015/12/18 06:00 PHST- 2015/12/18 06:00 [entrez] PHST- 2015/12/18 06:00 [pubmed] PHST- 2016/04/29 06:00 [medline] PHST- 2016/12/16 00:00 [pmc-release] AID - CD009814.pub2 [pii] AID - 10.1002/14651858.CD009814.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2015 Dec 16;2015(12):CD009814. doi: 10.1002/14651858.CD009814.pub2. PMID- 29338989 OWN - NLM STAT- MEDLINE DCOM- 20180906 LR - 20180906 IS - 1545-1534 (Electronic) IS - 1080-6032 (Linking) VI - 29 IP - 1 DP - 2018 Mar TI - Relations Between Self-Reported and Linguistic Monitoring Assessments of Affective Experience in an Extreme Environment. PG - 61-65 LID - S1080-6032(17)30258-2 [pii] LID - 10.1016/j.wem.2017.08.023 [doi] AB - INTRODUCTION: Approaches for monitoring psychosocial health in challenging environments are needed to maintain the performance and safety of personnel. The purpose of the present research was to examine the relationship between 2 candidate methods (self-reported and linguistics) for monitoring affective experience during extreme environment activities. METHODS: A single-subject repeated-measures design was used in the present work. The participant was a 46-year-old individual scheduled to complete a self-supported ski expedition across Arctic Greenland. The expedition lasted 28 days, and conditions included severe cold, low stimulation, whiteouts, limited habitability, and threats to life and limb. During the expedition, the participant completed a daily self-report log including assessment of psychological health (perceptions of control and affect) and a video diary (emotion). Video diary entries were subjected to linguistic inquiry and word count analyses before the links between self-report and linguistic data across the expedition period were tested. RESULTS: Similarities in the pattern of self-reported and linguistic assessments emerged across the expedition period. A number of predictable correlations were identified between self-reported and linguistic assessments of affective/emotional experience. Overall, there was better agreement between self-reports and linguistic analytics for indicators of negative affect/emotion. CONCLUSIONS: Future research should build on this initial study to further test the links between self-reported affect and emotional states monitored via linguistics. This could help develop methods for monitoring psychological health in extreme environments and support organizational decision making. CI - Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved. FAU - Smith, Nathan AU - Smith N AD - University of Northampton, Northampton, United Kingdom. Electronic address: nathan.j.smithphd@gmail.com. LA - eng PT - Journal Article DEP - 20180112 PL - United States TA - Wilderness Environ Med JT - Wilderness & environmental medicine JID - 9505185 SB - IM MH - *Extreme Environments MH - Greenland MH - Humans MH - *Linguistics MH - Male MH - *Mental Health MH - Middle Aged MH - Psychometrics/*methods MH - *Self Report MH - Skiing/*psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - emotion OT - extreme environment OT - linguistic analysis OT - monitoring OT - self-reports EDAT- 2018/01/18 06:00 MHDA- 2018/09/07 06:00 CRDT- 2018/01/18 06:00 PHST- 2017/06/18 00:00 [received] PHST- 2017/08/17 00:00 [revised] PHST- 2017/08/31 00:00 [accepted] PHST- 2018/01/18 06:00 [pubmed] PHST- 2018/09/07 06:00 [medline] PHST- 2018/01/18 06:00 [entrez] AID - S1080-6032(17)30258-2 [pii] AID - 10.1016/j.wem.2017.08.023 [doi] PST - ppublish SO - Wilderness Environ Med. 2018 Mar;29(1):61-65. doi: 10.1016/j.wem.2017.08.023. Epub 2018 Jan 12. PMID- 30281842 OWN - NLM STAT- MEDLINE DCOM- 20200413 LR - 20210109 IS - 1365-2125 (Electronic) IS - 0306-5251 (Print) IS - 0306-5251 (Linking) VI - 85 IP - 6 DP - 2019 Jun TI - Special considerations for clinical trials in fibrodysplasia ossificans progressiva (FOP). PG - 1199-1207 LID - 10.1111/bcp.13777 [doi] AB - Clinical trials for orphan diseases are critical for developing effective therapies. One such condition, fibrodysplasia ossificans progressiva (FOP; MIM#135100), is characterized by progressive heterotopic ossification (HO) that leads to severe disability. Individuals with FOP are extremely sensitive to even minor traumatic events. There has been substantial recent interest in clinical trials for novel and urgently-needed treatments for FOP. The International Clinical Council on FOP (ICC) was established in 2016 to provide consolidated and coordinated advice on the best practices for clinical care and clinical research for individuals who suffer from FOP. The Clinical Trials Committee of the ICC developed a focused list of key considerations that encompass the specific and unique needs of the FOP community - considerations that are endorsed by the entire ICC. These considerations complement established protocols for developing and executing robust clinical trials by providing a foundation for helping to ensure the safety of subjects with FOP in clinical research trials. CI - © 2018 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. FAU - Hsiao, Edward C AU - Hsiao EC AUID- ORCID: 0000-0001-8924-106X AD - Division of Endocrinology and Metabolism, and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA, USA. FAU - Di Rocco, Maja AU - Di Rocco M AD - Unit of Rare Diseases, Department of Pediatrics, IRCCS Giannina Gaslini Institute, Genoa, Italy. FAU - Cali, Amanda AU - Cali A AD - Radiant Hope Foundation and the Ian Cali FOP Research Fund, PENN Medicine, Center for Research in FOP & Related Disorders. FAU - Zasloff, Michael AU - Zasloff M AD - Departments of Orthopaedic Surgery and Genetics, The Center for Research in FOP & Related Disorders, University of Pennsylvania School of Medicine; and MedStar Georgetown Transplant Institute Georgetown University School of Medicine, Washington, DC, USA. FAU - Al Mukaddam, Mona AU - Al Mukaddam M AD - Division of Endocrinology, Diabetes and Metabolism, Departments of Medicine and Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. FAU - Pignolo, Robert J AU - Pignolo RJ AD - Department of Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Grunwald, Zvi AU - Grunwald Z AD - Department of Anesthesiology, Thomas Jefferson University, Philadelphia, PA, USA. FAU - Netelenbos, Coen AU - Netelenbos C AD - Department of Internal Medicine section Endocrinology, Amsterdam Bone Center, Amsterdam University Medical Centers location VUmc, Amsterdam, the Netherlands. FAU - Keen, Richard AU - Keen R AD - Royal National Orthopaedic Hospital, Stanmore, UK. FAU - Baujat, Genevieve AU - Baujat G AD - Centre de Référence Maladies Osseuses Constitutionnelles, Departement de Génétique, Hôpital Necker-Enfants Malades, Institut Imagine, Paris, France. FAU - Brown, Matthew A AU - Brown MA AD - Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Woolloongabba, QLD, Australia. FAU - Cho, Tae-Joon AU - Cho TJ AD - Division of Pediatric Orthopaedics, Seoul National University Children's Hospital, Seoul, South Korea. FAU - De Cunto, Carmen AU - De Cunto C AD - Pediatric Rheumatology Section, Department of Pediatrics, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. FAU - Delai, Patricia AU - Delai P AD - Hospital Israelita Albert Einstein, Instituto de Ensino e Pesquisa, São Paulo-SP, Brazil. FAU - Haga, Nobuhiko AU - Haga N AD - Department of Rehabilitation Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. FAU - Morhart, Rolf AU - Morhart R AD - Department of Pediatrics, Klinikum Garmisch-Partenkirchen GmbH, Garmisch-Partenkirchen, Germany. FAU - Scott, Christiaan AU - Scott C AD - Paediatric Rheumatology, Red Cross Children's Hospital, University of Cape Town, Cape Town, South Africa. FAU - Zhang, Keqin AU - Zhang K AD - Department of Endocrinology, Tongji Hospital, Shanghai Tongji University, Shanghai, China. FAU - Diecidue, Robert J AU - Diecidue RJ AD - Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. FAU - Friedman, Clive S AU - Friedman CS AD - Schulich School of Medicine and Dentistry, Pediatric Oral Health and Dentistry, London, ON, Canada. FAU - Kaplan, Fredrick S AU - Kaplan FS AD - Departments of Medicine & Orthopaedic Surgery, Center for Research in FOP & Related Disorders, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Eekhoff, Elisabeth M W AU - Eekhoff EMW AD - Department of Internal Medicine section Endocrinology, Amsterdam Bone Center, Amsterdam University Medical Centers location VUmc, Amsterdam, the Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20181106 PL - England TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 SB - IM MH - Bone Remodeling/*drug effects MH - Clinical Trials as Topic/*methods MH - Consensus MH - Humans MH - Myositis Ossificans/diagnosis/*drug therapy/physiopathology MH - Ossification, Heterotopic/diagnosis/*drug therapy/physiopathology MH - Patient Safety MH - Patient Selection MH - *Research Design MH - Stakeholder Participation PMC - PMC6533500 OTO - NOTNLM OT - Fibrodysplasia ossificans progressiva (FOP) OT - patient safety OT - rare disease clinical trials COIS- E.C.H., M.D.R., M.Z., M.A.M., R.J.P., C.N., R.K., G.B., M.A.B., C.D.C., P.D., N.H., F.S.K. and E.M.W.E. receive clinical trials research support from Clementia Pharmaceuticals. R.J.D. and R.M. are consultants for Clementia Pharmaceuticals. M.Z. is on the data safety monitoring board for Clementia Pharmaceuticals. E.C.H., M.A.M., R.J.P., M.D.R., M.A.B., E.M.W.E., R.K., and F.S.K. receive clinical trials research funding from Regeneron Pharmaceuticals. R.M. is a paid consultant for Regeneron Pharmaceuticals. E.C.H., C.N., R.K., G.B., M.A.B., C.D.C., M.D.R., R.J.P., M.Z., P.D., C.S., N.H., K.Z., R.M., F.S.K. and E.M.W.E. also serve as unpaid volunteers on the International FOP Association Medical Registry Advisory Board. E.C.H., E.M.W.E., R.J.P. and F.S.K. serve as unpaid volunteers on the FOP Biomarker Consortium. E.C.H. also serves as an unpaid volunteer on the Fibrous Dysplasia Foundation Medical Advisory Board. M.D.R. is a consultant and/or speaker for Sanofi‐Genzyme, Shire, Alexion, Biomarin, Chiesi, Clementia Pharmaceuticals, and Regeneron Pharmaceuticals. M.D.R. receives clinical trial research support from Sanofi, Genzyme, Alexion, Enzyvant. A.C. is a trustee of the Radiant Hope Foundation and trustee of the Ian Cali FOP Research Fund ‐ PENN Medicine ‐ Center for Research in FOP & Related Disorders, and is an unpaid volunteer with Clementia Pharmaceuticals Burden of Illness Advisory Group. P.D. is an unpaid medical advisor for FOP Brazil. M.A.M. and M.Z. are nonpaid consultants for BioCryst. E.M.W.E. is an advisor for AstraZenica and Blueprint Pharmaceuticals. Z.G. is a nonpaid consultant for the Natural History Study on FOP Board. R.K. also receives research support from UltraGenyx; is a paid consultant for Clementia Pharmaceuticals, Regeneron Pharmaceuticals, UltraGenyx, Internis, and Alexion; and is a nonpaid member of the Medical Advisory Board for the UK Brittle Bone Society. The authors thank the Center for Research in FOP & Related Disorder at the University of Pennsylvania for supporting the International Clinical Council for FOP (ICC). E.C.H. received salary support from the University of California – San Francisco Department of Medicine to support this work. F.S.K. received support from the Isaac & Rose Nassau Professorship of Orthopaedic Molecular Medicine at the University of Pennsylvania. R.J.P. received support from the Robert and Arlene Kogod Professorship and M.A.M. received funding from the Ian Cali FOP Clinical Scholarship. E.C.H. and R.J.P. received support from the Radiant Hope Foundation. EDAT- 2018/10/04 06:00 MHDA- 2020/04/14 06:00 PMCR- 2018/11/06 CRDT- 2018/10/04 06:00 PHST- 2018/08/11 00:00 [received] PHST- 2018/09/23 00:00 [revised] PHST- 2018/09/24 00:00 [accepted] PHST- 2018/10/04 06:00 [pubmed] PHST- 2020/04/14 06:00 [medline] PHST- 2018/10/04 06:00 [entrez] PHST- 2018/11/06 00:00 [pmc-release] AID - BCP13777 [pii] AID - 10.1111/bcp.13777 [doi] PST - ppublish SO - Br J Clin Pharmacol. 2019 Jun;85(6):1199-1207. doi: 10.1111/bcp.13777. Epub 2018 Nov 6. PMID- 28089964 OWN - NLM STAT- MEDLINE DCOM- 20180420 LR - 20180420 IS - 1948-2124 (Electronic) IS - 1079-7440 (Linking) VI - 71 IP - 4 DP - 2017 Jul-Aug TI - Increasing Patient Safety by Closing the Sterile Production Gap-Part 1. Introduction. PG - 261-268 LID - 10.5731/pdajpst.2016.007104 [doi] AB - Terminal sterilization is considered the preferred means for the production of sterile drug products because it affords enhanced safety for the patient as the formulation is filled into its final container, sealed, and sterilized. Despite the obvious patient benefits, the use of terminal sterilization is artificially constrained by unreasonable expectations for the minimum time-temperature process to be used. The core misunderstanding with terminal sterilization is a fixation that destruction of a high population of a resistant biological indicator is required. The origin of this misconception is unclear, but it has resulted in sterilization conditions that are extremely harsh (15 min at 121 °C, of F(0) > 8 min), which limit the use of terminal sterilization to extremely heat-stable formulations. These articles outline the artificial nature of the process constraints and describe a scientifically sound means to expand the use of terminal sterilization by identifying the correct process goal-destruction of the bioburden present in the container prior to sterilization. Recognition that the true intention is bioburden destruction in routine products allows for the use of reduced conditions (lower temperatures, shorter process dwell, or both) without added patient risk. By focusing attention on the correct process target, lower time-temperature conditions can be used to expand the use of terminal sterilization to products unable to withstand the harsh conditions that have been mistakenly applied. The first article provides the background and describes the benefits to patient, producer, and regulator. The second article includes validation and operational advice that can be used in the implementation.LAY ABSTRACT: Terminal sterilization is considered the preferred means for the production of sterile drug products because it affords enhanced safety for the patient as the formulation is filled into its final container, sealed, and sterilized. Despite the obvious patient benefits, the use of terminal sterilization is artificially constrained by unreasonable expectations for the minimum time-temperature process to be used. These articles outline the artificial nature of the process constraints and describe a scientifically sound means to expand the use of terminal sterilization by identifying the correct process goal-destruction of the bioburden present in the container prior to sterilization. By focusing attention on the correct process target, lower time-temperature conditions can be used to expand the use of terminal sterilization to products unable to withstand the harsh conditions that have been mistakenly applied. The first article provides the background, and describes the benefits to patient, producer, and regulator. The second article includes validation and operational advice that can be used in the implementation. CI - © PDA, Inc. 2017. FAU - Agalloco, James P AU - Agalloco JP AD - Agalloco & Associates Inc., 22 Carriage Trail, Belle Mead, NJ 08502 jagalloco@aol.com. LA - eng PT - Journal Article PT - Review DEP - 20170115 PL - United States TA - PDA J Pharm Sci Technol JT - PDA journal of pharmaceutical science and technology JID - 9439538 RN - 0 (Pharmaceutical Preparations) SB - IM MH - Drug Compounding/methods/standards MH - Drug Industry/methods MH - Drug Packaging MH - Humans MH - *Patient Safety MH - Pharmaceutical Preparations/*standards MH - Sterilization/*methods MH - Temperature MH - Time Factors OTO - NOTNLM OT - Aseptic processing OT - Bioburden OT - Biological indicator OT - Probability of a non-sterile unit (PNSU) OT - Regulation OT - Sterility assurance OT - Sterilization OT - Terminal sterilization EDAT- 2017/01/17 06:00 MHDA- 2018/04/21 06:00 CRDT- 2017/01/17 06:00 PHST- 2017/01/17 06:00 [pubmed] PHST- 2018/04/21 06:00 [medline] PHST- 2017/01/17 06:00 [entrez] AID - pdajpst.2016.007104 [pii] AID - 10.5731/pdajpst.2016.007104 [doi] PST - ppublish SO - PDA J Pharm Sci Technol. 2017 Jul-Aug;71(4):261-268. doi: 10.5731/pdajpst.2016.007104. Epub 2017 Jan 15. PMID- 28089965 OWN - NLM STAT- MEDLINE DCOM- 20180420 LR - 20180420 IS - 1948-2124 (Electronic) IS - 1079-7440 (Linking) VI - 71 IP - 4 DP - 2017 Jul-Aug TI - Increasing Patient Safety by Closing the Sterile Production Gap-Part 2. Implementation. PG - 269-273 LID - 10.5731/pdajpst.2016.007112 [doi] AB - Terminal sterilization is considered the preferred means for the production of sterile drug products because it affords enhanced safety for the patient as the formulation is filled into its final container, sealed, and sterilized. Despite the obvious patient benefits, the use of terminal sterilization is artificially constrained by unreasonable expectations for the minimum time-temperature process to be used. The core misunderstanding with terminal sterilization is a fixation that destruction of a high concentration of a resistant biological indicator is required. The origin of this misconception is unclear, but it has resulted in sterilization conditions that are extremely harsh (15 min at 121 °C, of F(0) >8 min), which limit the use of terminal sterilization to extremely heat-stable formulations. These articles outline the artificial nature of the process constraints and describe a scientifically sound means to expand the use of terminal sterilization by identifying the correct process goal-the destruction of the bioburden present in the container prior to sterilization. Recognition that the true intention is bioburden destruction in routine products allows for the use of reduced conditions (lower temperatures, shorter process dwell, or both) without added patient risk. By focusing attention on the correct process target, lower time-temperature conditions can be used to expand the use of terminal sterilization to products unable to withstand the harsh conditions that have been mistakenly applied. The first article provides the background, and describes the benefits to patient, producer, and regulator. The second article includes validation and operational advice that can be used in the implementation.LAY ABSTRACT: Terminal sterilization is considered the preferred means for the production of sterile drug products because it affords enhanced safety for the patient as the formulation is filled into its final container, sealed, and sterilized. Despite the obvious patient benefits, the use of terminal sterilization is artificially constrained by unreasonable expectations for the minimum time-temperature process to be used. These articles outline the artificial nature of the process constraints and describe a scientifically sound means to expand the use of terminal sterilization by identifying the correct process goal-the destruction of the bioburden present in the container prior to sterilization. By focusing attention on the correct process target, lower time-temperature conditions can be used to expand the use of terminal sterilization to products unable to withstand the harsh conditions that have been mistakenly applied. The first article provides the background, and describes the benefits to patient, producer, and regulator. The article manuscript includes validation and operational advice that can be used in the implementation. CI - © PDA, Inc. 2017. FAU - Agalloco, James P AU - Agalloco JP AD - Agalloco & Associates Inc., 22 Carriage Trail, Belle Mead, NJ 08502 jagalloco@aol.com. LA - eng PT - Journal Article PT - Review DEP - 20170115 PL - United States TA - PDA J Pharm Sci Technol JT - PDA journal of pharmaceutical science and technology JID - 9439538 RN - 0 (Pharmaceutical Preparations) SB - IM MH - Drug Compounding/methods/standards MH - Drug Industry/methods MH - Humans MH - *Patient Safety MH - Pharmaceutical Preparations/*standards MH - Product Packaging MH - Sterilization/*methods MH - Temperature MH - Time Factors MH - Validation Studies as Topic OTO - NOTNLM OT - Aseptic processing OT - Bioburden OT - Biological indicator OT - Probability of a non-sterile unit (PNSU) OT - Regulation OT - Sterility assurance OT - Sterilization OT - Terminal sterilization EDAT- 2017/01/17 06:00 MHDA- 2018/04/21 06:00 CRDT- 2017/01/17 06:00 PHST- 2017/01/17 06:00 [pubmed] PHST- 2018/04/21 06:00 [medline] PHST- 2017/01/17 06:00 [entrez] AID - pdajpst.2016.007112 [pii] AID - 10.5731/pdajpst.2016.007112 [doi] PST - ppublish SO - PDA J Pharm Sci Technol. 2017 Jul-Aug;71(4):269-273. doi: 10.5731/pdajpst.2016.007112. Epub 2017 Jan 15. PMID- 29350006 OWN - NLM STAT- MEDLINE DCOM- 20180621 LR - 20181202 IS - 1003-0034 (Print) IS - 1003-0034 (Linking) VI - 30 IP - 2 DP - 2017 Feb 25 TI - [The shor-term clinical outcomes and safety of extreme lateral interbody fusion combined with percutaneous pedicle screw fixation for the treatment of degenerative lumbar disease]. PG - 147-151 LID - 10.3969/j.issn.1003-0034.2017.02.011 [doi] AB - OBJECTIVE: To evaluate the early efficacy and safety of extreme lateral interbody fusion (XLIF) combined with percutaneous pedicle screw fixation for lumbar degenerative disease. METHODS: From January 2013 to June 2014, 13 patients with degenerative lumbar disease were treated with XLIF combined with percutaneous pedicle screw fixation, including 8 cases of lumbar instability, 5 cases of mild to moderate lumbar spondylolisthesis;there were 5 males and 8 females, aged from 56 to 73 years with an average of 62.1 years. All patients were single segment fusion. Operation time, perioperative bleeding and perioperative complications were recorded. Visual analogue scale (VAS) and Oswestry Disability Index (ODI) were used to evaluate the clinical efficacy. Interbody fusion rate was observed and the intervertebral foramen area changes were compared preoperation and postoperation by X-rays and CT scanning. RESULTS: The mean operation time and perioperative bleeding in the patients respectively was(62.8±5.2) min and(82.5±22.6) ml. One case occurred in the numbness of femoribus internus and 1 case occurred in the muscle weakness of hip flexion after operation, both of them recovered within 2 weeks. All the patients were followed up from 12 to 19 months with an average of 15.6 months. VAS was decreased from preoperative 7.31±0.75 to 2.31±0.75 at final follow-up(P<0.05); ODI was decreased from preoperative (42.58±1.55)% to (12.55±0.84)% at final follow-up(P<0.05). At final follow-up, CT scanning confirmed 8 cases completely fused and 5 cases partly fused;the intervertebral foramen area was increased from preoperative (94.86±2.44)mm2 to (150.70±7.02)mm2(P<0.05). CONCLUSIONS: Extreme lateral interbody fusion combined with percutaneous pedicle screw fixation is an ideal method and can obtain early good clinical effects in treating lumbar degenerative disease. FAU - Hu, Xu-Dong AU - Hu XD AD - Department of Spinal Surgery, Zhejiang Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China. FAU - Ma, Wei-Hu AU - Ma WH AD - Department of Spinal Surgery, Zhejiang Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China; weihu_ma@163.com. FAU - Jiang, Wei-Yu AU - Jiang WY AD - Department of Spinal Surgery, Zhejiang Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China. FAU - Ruan, Chao-Yue AU - Ruan CY AD - Department of Spinal Surgery, Zhejiang Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China. FAU - Chen, Yun-Lin AU - Chen YL AD - Department of Spinal Surgery, Zhejiang Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China. LA - chi PT - Journal Article PL - China TA - Zhongguo Gu Shang JT - Zhongguo gu shang = China journal of orthopaedics and traumatology JID - 9815790 SB - IM MH - Aged MH - Female MH - Humans MH - Lumbar Vertebrae/*surgery MH - Male MH - Middle Aged MH - *Pedicle Screws MH - Safety MH - Spinal Fusion/adverse effects/*methods MH - Spondylolisthesis/*surgery MH - Treatment Outcome OTO - NOTNLM OT - Degenerative lumbar disease OT - Extreme lateral interbody fusion OT - Percutaneous fixation OT - Safety OT - Treatment outcome COIS- The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. EDAT- 2018/01/20 06:00 MHDA- 2018/06/22 06:00 CRDT- 2018/01/20 06:00 PHST- 2016/06/02 00:00 [received] PHST- 2018/01/20 06:00 [entrez] PHST- 2018/01/20 06:00 [pubmed] PHST- 2018/06/22 06:00 [medline] AID - 10.3969/j.issn.1003-0034.2017.02.011 [doi] PST - ppublish SO - Zhongguo Gu Shang. 2017 Feb 25;30(2):147-151. doi: 10.3969/j.issn.1003-0034.2017.02.011. PMID- 32677419 OWN - NLM STAT- MEDLINE DCOM- 20211104 LR - 20211213 IS - 2724-5365 (Electronic) IS - 2724-5985 (Linking) VI - 67 IP - 1 DP - 2021 Mar TI - Small bowel capsule endoscopy: where do we stand after 20 years of clinical use? PG - 101-108 LID - 10.23736/S2724-5985.20.02745-2 [doi] AB - Small bowel capsule endoscopy (SBCE) was introduced into clinical practice almost 20 years ago and, nowadays, it is an essential tool for the study of the small bowel. SBCE allows a radiation-free examination of the entire mucosal surface of the small bowel with high-quality images, limited invasivity and a good safety profile. Nevertheless, the main limitation of SBCE is the lack of any possible direct therapeutic intervention. Indications for SBCE have evolved throughout the years, from "old" ones such as suspected small bowel bleeding (still the main indication for SBCE) to newer ones such as refractory celiac disease, hereditary polyposis syndromes and Crohn's disease. Thus, nowadays SBCE has a key role in the diagnostic algorithms in many conditions. Furthermore, the introduction in the SBCE field of cutting-edge technologies, as artificial intelligence systems, is likely to shorten the reading time making SBCE even more effective and easy to perform. Preliminary data are extremely promising and solid evidence is being gathered by current studies. FAU - Pennazio, Marco AU - Pennazio M AD - University Division of Gastroenterology, Città della Salute e della Scienza, University of Turin, Turin, Italy - pennazio.marco@gmail.com. FAU - Rondonotti, Emanuele AU - Rondonotti E AD - Gastroenterology Unit, Valduce Hospital, Como, Italy. FAU - Pellicano, Rinaldo AU - Pellicano R AD - University Division of Gastroenterology, Città della Salute e della Scienza, University of Turin, Turin, Italy. FAU - Cortegoso Valdivia, Pablo AU - Cortegoso Valdivia P AD - Gastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, Parma, Italy. LA - eng PT - Journal Article PT - Review DEP - 20200716 PL - Italy TA - Minerva Gastroenterol (Torino) JT - Minerva gastroenterology JID - 101777280 SB - IM MH - Algorithms MH - *Capsule Endoscopy MH - Humans MH - Intestinal Diseases/*pathology MH - Intestine, Small/*pathology MH - Time Factors EDAT- 2020/07/18 06:00 MHDA- 2021/11/05 06:00 CRDT- 2020/07/18 06:00 PHST- 2020/07/18 06:00 [pubmed] PHST- 2021/11/05 06:00 [medline] PHST- 2020/07/18 06:00 [entrez] AID - S1121-421X.20.02745-2 [pii] AID - 10.23736/S2724-5985.20.02745-2 [doi] PST - ppublish SO - Minerva Gastroenterol (Torino). 2021 Mar;67(1):101-108. doi: 10.23736/S2724-5985.20.02745-2. Epub 2020 Jul 16. PMID- 8033427 OWN - NLM STAT- MEDLINE DCOM- 19940816 LR - 20181113 IS - 0009-9104 (Print) IS - 1365-2249 (Electronic) IS - 0009-9104 (Linking) VI - 97 Suppl 1 IP - Suppl 1 DP - 1994 Jul TI - Intravenous immune globulin in primary immunodeficiency. PG - 11-5 AB - The development of safe and effective intravenous preparations of immune globulin (IVIG) represents a major advance in the treatment of patients with severe antibody deficiencies. Such therapy is expensive, few trials have been performed to compare one type of IVIG preparation with another under equivalent conditions, and published studies have been of relatively short duration. The overall consensus is that high-dose IVIG (at least 400/mg/kg/month) is superior to lower doses and most clinicians aim to maintain trough IgG levels above an arbitrary level of 5 g/l. Adverse reactions, usually mild, are common in antibody-deficient patients during the first few infusions, but severe, anaphylactoid reactions are extremely rare other than in patients with antibodies to IgA. IVIG is not associated with transmission of human immunodeficiency virus or hepatitis B, but there remains a small but definite risk of transmission of non-A, non-B hepatitis, including hepatitis C. Self-infusion of IVIG in the patient's home is a realistic alternative to hospitalization. In the UK, guidelines for home therapy have been approved by professional medical bodies and by the Department of Health. Home therapy has proven to be both safe and cost-effective. FAU - Haeney, M AU - Haeney M AD - Hope Hospital, University of Manchester School of Medicine, Salford, UK. LA - eng PT - Journal Article PT - Review PL - England TA - Clin Exp Immunol JT - Clinical and experimental immunology JID - 0057202 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Hepatitis C/transmission MH - Home Care Services MH - Humans MH - Immunoglobulins, Intravenous/administration & dosage/adverse effects/*therapeutic use MH - Immunologic Deficiency Syndromes/*therapy MH - Safety MH - Self Administration MH - United Kingdom PMC - PMC1550367 EDAT- 1994/07/01 00:00 MHDA- 1994/07/01 00:01 PMCR- 1995/07/01 CRDT- 1994/07/01 00:00 PHST- 1994/07/01 00:00 [pubmed] PHST- 1994/07/01 00:01 [medline] PHST- 1994/07/01 00:00 [entrez] PHST- 1995/07/01 00:00 [pmc-release] PST - ppublish SO - Clin Exp Immunol. 1994 Jul;97 Suppl 1(Suppl 1):11-5. PMID- 8476452 OWN - NLM STAT- MEDLINE DCOM- 19930525 LR - 20190830 IS - 0735-6757 (Print) IS - 0735-6757 (Linking) VI - 11 IP - 2 DP - 1993 Mar TI - The efficacy and safety of a continuous albuterol protocol for the treatment of acute adult asthma attacks. PG - 131-3 AB - We performed a prospective study over a 6-month period to test the efficacy and safety of a continuous nebulized albuterol protocol for the treatment of acute adult asthma attacks. All patients 18 years or older presenting to the emergency department with acute asthma attacks were begun by the triage nurse on the protocol of three continuous albuterol (2.5 mg) nebulizer treatments. Pretreatment and posttreatment peak flow, respiratory rate, pulse, and blood pressure were documented and patients gave a pretreatment and posttreatment rating of the clinical severity of their attack using a (1 to 10) visual analog scale. In addition, all adverse effects were noted. Seventy-six patients were entered in the study. The average age was 44 years (range, 20 to 82 years). Pretreatment and posttreatment peak flow, respiratory rate, pulse, blood pressure, and clinical severity were compared using the paired t test. Patients showed statistically significant increases in peak flow (128 to 292; P < .0001) and statistically significant decreases in respiratory rate (27 to 20; P < .0001); pulse, 103 to 94 (P < .0001); clinical severity, 7.8/10 to 1.8/10 (P < .0001); and blood pressure, 141/82 to 132/77 (P < .001). Adverse effects were minimal. Two patients (2.6%) felt flushed, three patients (4%) felt jittery, and one patient (1.3%) had a sensation of palpitations. We conclude that a continuous nebulized albuterol protocol is both extremely efficacious and safe for the treatment of acute adult asthma attacks. FAU - Olshaker, J AU - Olshaker J AD - Department of Surgery, University of Maryland Medical Center, Baltimore, MD. FAU - Jerrard, D AU - Jerrard D FAU - Barish, R A AU - Barish RA FAU - Brandt, G AU - Brandt G FAU - Hooper, F AU - Hooper F LA - eng PT - Journal Article PL - United States TA - Am J Emerg Med JT - The American journal of emergency medicine JID - 8309942 RN - QF8SVZ843E (Albuterol) SB - IM CIN - Am J Emerg Med. 1994 Jan;12(1):123-4. doi: 10.1016/0735-6757(94)90221-6. PMID: 8285959 CIN - Am J Emerg Med. 1994 Jan;12(1):123-4. doi: 10.1016/0735-6757(94)90220-8. PMID: 8285960 MH - Acute Disease MH - Administration, Intranasal MH - Adult MH - Aged MH - Aged, 80 and over MH - Albuterol/*administration & dosage MH - Asthma/*drug therapy/physiopathology MH - Emergencies MH - Female MH - Humans MH - Male MH - Middle Aged MH - Nebulizers and Vaporizers MH - Prospective Studies MH - Safety EDAT- 1993/03/01 00:00 MHDA- 1993/03/01 00:01 CRDT- 1993/03/01 00:00 PHST- 1993/03/01 00:00 [pubmed] PHST- 1993/03/01 00:01 [medline] PHST- 1993/03/01 00:00 [entrez] AID - 0735-6757(93)90105-K [pii] AID - 10.1016/0735-6757(93)90105-k [doi] PST - ppublish SO - Am J Emerg Med. 1993 Mar;11(2):131-3. doi: 10.1016/0735-6757(93)90105-k. PMID- 30507437 OWN - NLM STAT- MEDLINE DCOM- 20190617 LR - 20220129 IS - 1474-5488 (Electronic) IS - 1470-2045 (Linking) VI - 19 IP - 12 DP - 2018 Dec TI - Defining priority medical devices for cancer management: a WHO initiative. PG - e709-e719 LID - S1470-2045(18)30658-2 [pii] LID - 10.1016/S1470-2045(18)30658-2 [doi] AB - Medical devices are indispensable for cancer management across the entire cancer care continuum, yet many existing medical interventions are not equally accessible to the global population, contributing to disparate mortality rates between countries with different income levels. Improved access to priority medical technologies is required to implement universal health coverage and deliver high-quality cancer care. However, the selection of appropriate medical devices at all income and hospital levels has been difficult because of the extremely large number of devices needed for the full spectrum of cancer care; the wide variety of options within the medical device sector, ranging from small inexpensive disposable devices to sophisticated diagnostic imaging and treatment units; and insufficient in-country expertise, in many countries, to prioritise cancer interventions and to determine associated technologies. In this Policy Review, we describe the methods, process, and outcome of a WHO initiative to define a list of priority medical devices for cancer management. The methods, approved by the WHO Guidelines Review Committee, can be used as a model approach for future endeavours to define and select medical devices for disease management. The resulting list provides ready-to-use guidance for the selection of devices to establish, maintain, and operate necessary clinical units within the continuum of care for six cancer types, with the goal of promoting efficient resource allocation and increasing access to priority medical devices, particularly in low-income and middle-income countries. CI - Copyright © 2018 World Health Organization. Published by Elsevier Ltd. All rights reserved. Published by Elsevier Ltd.. All rights reserved. FAU - Velazquez Berumen, Adriana AU - Velazquez Berumen A AD - Essential Medicines and Health Products, WHO, Geneva, Switzerland. Electronic address: velazquezberumena@who.int. FAU - Jimenez Moyao, Gabriela AU - Jimenez Moyao G AD - Hospital Management Unit, Doctors Without Borders, Brussels, Belgium. FAU - Rodriguez, Natalia M AU - Rodriguez NM AD - Institute for Advanced Study of the Americas, and Department of Anthropology, College of Arts and Sciences, University of Miami, Florida, FL, USA. FAU - Ilbawi, André M AU - Ilbawi AM AD - Management of Noncommunicable Diseases, Disability, Violence and Injury Prevention, WHO, Geneva, Switzerland. FAU - Migliore, Antonio AU - Migliore A AD - Agenas, Agenzia nazionale per i servizi sanitari regionali, Rome, Italy. FAU - Shulman, Lawrence N AU - Shulman LN AD - Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, PA, USA. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Lancet Oncol JT - The Lancet. Oncology JID - 100957246 SB - IM MH - Clinical Decision-Making MH - Government Regulation MH - Health Policy/*legislation & jurisprudence MH - Health Services Needs and Demand/legislation & jurisprudence MH - Humans MH - *Medical Device Legislation MH - Medical Oncology/*instrumentation/*legislation & jurisprudence MH - Needs Assessment/legislation & jurisprudence MH - Neoplasms/*diagnosis/*therapy MH - Patient Safety/legislation & jurisprudence MH - *Policy Making MH - *World Health Organization EDAT- 2018/12/07 06:00 MHDA- 2019/06/18 06:00 CRDT- 2018/12/04 06:00 PHST- 2018/05/31 00:00 [received] PHST- 2018/08/20 00:00 [revised] PHST- 2018/08/21 00:00 [accepted] PHST- 2018/12/04 06:00 [entrez] PHST- 2018/12/07 06:00 [pubmed] PHST- 2019/06/18 06:00 [medline] AID - S1470-2045(18)30658-2 [pii] AID - 10.1016/S1470-2045(18)30658-2 [doi] PST - ppublish SO - Lancet Oncol. 2018 Dec;19(12):e709-e719. doi: 10.1016/S1470-2045(18)30658-2. PMID- 39879579 OWN - NLM STAT- Publisher LR - 20250129 IS - 1538-957X (Electronic) IS - 1538-9588 (Linking) DP - 2025 Jan 29 TI - A study on the optimal safety speed and warning sign distance for highways in windy and sandy environments based on driving behavior. PG - 1-9 LID - 10.1080/15389588.2024.2443548 [doi] AB - OBJECTIVE: This study aims to address the issue of driving safety on highways in the desert region of Northwest China during extreme weather conditions such as sandstorms, with the goal of reducing driver risk. It explores driver behavior under extreme conditions of sandstorms and sand accumulation, proposing safety speed recommendations and warning models for different environments to calculate the optimal warning distance in windy and sandy conditions. METHODS: Natural driving simulation experiments were conducted in windy and sandy environments, collecting driving behavior data from 45 drivers under varying visibility and road conditions with or without sand accumulation. This data were utilized to determine safe speeds before and after deceleration, as well as before and after lane changes. Warning models were established for both sandstorm and sand accumulation conditions. RESULTS: Driving stages in sandy environments were classified into normal driving, deceleration and low-speed stable driving phases. In sandstorm-sand accumulation environments, the stages included driving, lane changing and low-speed stable driving after lane changes. The recommended post-deceleration speeds for visibility levels of 2000, 500, 300, 150, 100 and 50 m were 120 km/h, 90 km/h, 70 km/h, 60 km/h, 50 km/h and 40 km/h, respectively. The recommended speeds after lane changes in sand-accumulated areas were 90 km/h, 80 km/h, 60 km/h, 60 km/h, 50 km/h and 40 km/h. The optimal warning distance for highways in windy and sandy environments was calculated to be 1100 m. CONCLUSION: The recommended safe speeds under different visibility conditions in sandstorms and sand accumulation environments are important references for future regulations. The suggested warning distance for highway signs is 1100 m, which can effectively ensure driving safety and reduce accident risks. FAU - Wang, Fang AU - Wang F AD - School of Civil and Hydraulic Engineering, NingXia University, YinChuan, China. FAU - Duan, WeiJia AU - Duan W AD - School of Civil and Hydraulic Engineering, NingXia University, YinChuan, China. FAU - Yang, Hao AU - Yang H AD - Planning and Operation Department, Ningxia Jiaotou Expressway Management Co, YinChuan, China. FAU - He, Tao AU - He T AD - Planning and Operation Department, Ningxia Jiaotou Expressway Management Co, YinChuan, China. FAU - Liu, ShiXiao AU - Liu S AD - School of Civil and Hydraulic Engineering, NingXia University, YinChuan, China. FAU - Huang, SiPing AU - Huang S AD - School of Civil and Hydraulic Engineering, NingXia University, YinChuan, China. LA - eng PT - Journal Article DEP - 20250129 PL - England TA - Traffic Inj Prev JT - Traffic injury prevention JID - 101144385 SB - IM OTO - NOTNLM OT - Sandstorm OT - driving behavior OT - driving simulation OT - early warning OT - highway EDAT- 2025/01/29 18:21 MHDA- 2025/01/29 18:21 CRDT- 2025/01/29 16:12 PHST- 2025/01/29 18:21 [medline] PHST- 2025/01/29 18:21 [pubmed] PHST- 2025/01/29 16:12 [entrez] AID - 10.1080/15389588.2024.2443548 [doi] PST - aheadofprint SO - Traffic Inj Prev. 2025 Jan 29:1-9. doi: 10.1080/15389588.2024.2443548. PMID- 20632314 OWN - NLM STAT- MEDLINE DCOM- 20110228 LR - 20211203 IS - 1097-0274 (Electronic) IS - 0271-3586 (Print) IS - 0271-3586 (Linking) VI - 53 IP - 11 DP - 2010 Nov TI - Photovoice in the workplace: A participatory method to give voice to workers to identify health and safety hazards and promote workplace change-a study of university custodians. PG - 1150-8 LID - 10.1002/ajim.20873 [doi] AB - BACKGROUND: Photovoice, a photographic participatory action research methodology was used in a workplace setting to assess hazards that were creating extremely high injury and incidents rates for university custodians and to promote the conditions to eliminate or reduce those hazards. METHODS: University custodians participated in a Photovoice project to identify, categorize, and prioritize occupational hazards and to discuss and propose solutions to these problems. Results were presented to management and to all custodians for further discussion. The effort was led by a worker-based union-sponsored participatory evaluation team in partnership with a university researcher. RESULTS: Visual depiction of hazardous tasks and exposures among custodians and management focused primarily on improper or unsafe equipment, awkward postures, lifting hazards, and electrical hazards. The process of taking pictures and presenting them created an ongoing discussion among workers and management regarding the need for change and for process improvements, and resulted in greater interest and activity regarding occupational health among the workers. In a follow-up evaluation 1-year later, a number of hazards identified through Photovoice had been corrected. Injury rates for custodians had decreased from 39% to 26%. CONCLUSIONS: Photovoice can be an important tool, not just for identifying occupational hazards, but also empowering workers to be more active around health and safety and may facilitate important changes in the workplace. CI - © 2010 Wiley-Liss, Inc. FAU - Flum, Marian R AU - Flum MR AD - Work Environment Department, University of Massachusetts Lowell, 01854, USA. marian_flum@uml.edu FAU - Siqueira, Carlos Eduardo AU - Siqueira CE FAU - DeCaro, Anthony AU - DeCaro A FAU - Redway, Scott AU - Redway S LA - eng GR - U45 ES006172/ES/NIEHS NIH HHS/United States GR - U45 ES007823/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 SB - IM MH - Accidents, Occupational/*prevention & control MH - Community Participation/*methods MH - Female MH - *Household Work MH - Humans MH - Iowa MH - Maintenance MH - Male MH - Middle Aged MH - *Occupational Health MH - *Photography MH - *Safety MH - Safety Management/*methods/organization & administration MH - Universities PMC - PMC2957512 MID - NIHMS217265 EDAT- 2010/07/16 06:00 MHDA- 2011/03/01 06:00 PMCR- 2011/11/01 CRDT- 2010/07/16 06:00 PHST- 2010/07/16 06:00 [entrez] PHST- 2010/07/16 06:00 [pubmed] PHST- 2011/03/01 06:00 [medline] PHST- 2011/11/01 00:00 [pmc-release] AID - 10.1002/ajim.20873 [doi] PST - ppublish SO - Am J Ind Med. 2010 Nov;53(11):1150-8. doi: 10.1002/ajim.20873. PMID- 38604180 OWN - NLM STAT- MEDLINE DCOM- 20240528 LR - 20240530 IS - 1348-9585 (Electronic) IS - 1341-9145 (Print) IS - 1341-9145 (Linking) VI - 66 IP - 1 DP - 2024 Jan 4 TI - Heat and health of occupational workers: a short summary of literature. LID - 10.1093/joccuh/uiae018 [doi] LID - uiae018 AB - Globally, occupational workers suffer various health impacts due to extreme heat. In this short review, we examine the literature discussing health impacts of heat on occupational workers, and then discuss certain individual and institutional measures needed to address the problem. Though the available literature in the recent decade discusses health impacts of heat on workers as various heat-related illnesses, we found very few studies examining how occupational workers suffer from issues concerning cardiovascular health, neurological health, respiratory health, and mental health. In this regard, we highlight the need for more studies to examine how occupational workers exposed to extreme heat conditions suffer from fatal health issues like cardiovascular attack, brain stroke, and other ailments impacting vital organs of the body. Occupational workers across the world should be made aware of measures to protect themselves from extreme heat. Further, countries should develop occupational heat safety guidelines with statutory effect. CI - © The Author(s) [2024]. Published by Oxford University Press on behalf of Journal of Occupational Health. FAU - N, Sai Venkata Sarath Chandra AU - N SVSC AUID- ORCID: 0009-0007-8865-9625 AD - School of Medicine and Dentistry, Parklands Drive, Southport, Gold Coast Campus, Griffith University, QLD 4222, Australia. FAU - Xu, Zhiwei AU - Xu Z AUID- ORCID: 0000-0001-7903-2141 AD - School of Medicine and Dentistry, Parklands Drive, Southport, Gold Coast Campus, Griffith University, QLD 4222, Australia. LA - eng PT - Journal Article PT - Review PL - Australia TA - J Occup Health JT - Journal of occupational health JID - 9616320 SB - IM MH - Humans MH - *Occupational Exposure/adverse effects MH - *Heat Stress Disorders MH - *Occupational Diseases/etiology MH - *Occupational Health MH - Hot Temperature/adverse effects MH - Extreme Heat/adverse effects PMC - PMC11131018 OTO - NOTNLM OT - health OT - heat waves OT - workers COIS- The authors declare no conflicts of interest that influence the work reported in this paper. EDAT- 2024/04/12 00:43 MHDA- 2024/05/28 12:44 PMCR- 2024/04/11 CRDT- 2024/04/11 18:43 PHST- 2023/12/07 00:00 [received] PHST- 2024/02/02 00:00 [revised] PHST- 2024/03/21 00:00 [accepted] PHST- 2024/05/28 12:44 [medline] PHST- 2024/04/12 00:43 [pubmed] PHST- 2024/04/11 18:43 [entrez] PHST- 2024/04/11 00:00 [pmc-release] AID - 7644305 [pii] AID - uiae018 [pii] AID - 10.1093/joccuh/uiae018 [doi] PST - ppublish SO - J Occup Health. 2024 Jan 4;66(1):uiae018. doi: 10.1093/joccuh/uiae018. PMID- 26821506 OWN - NLM STAT- MEDLINE DCOM- 20160211 LR - 20160129 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 154 IP - 11 DP - 2015 Nov TI - [THE APPROACH TO NAUSEA AND VOMITING IN PREGNANCY]. PG - 720-4, 741 AB - Nausea and vomiting of pregnancy (NVP) is the most prevalent medical condition during gestation. Approximately 85% of pregnant women suffer from some degree of this condition, while hyperemesis gravidarum (HG), the most severe form, affects up to 2% of women. Although being the leading cause for hospitalization during pregnancy, NVP has received little attention from the medical community. NVP negatively affects women's quality of life, household activity and work productivity. In Canada, the financial cost of NVP, ranges from $132 to $653 per woman/week. In extreme cases, severe NVP results in therapeutic abortions. On the other hand, NVP has been shown to have a protective effect against spontaneous abortions and congenital malformations. Lately, there has been an interest in the hypothesis that NVP is a mechanism protecting the fetus from phytochemicals. Early treatment can prevent future complications and deterioration of the symptoms. Various studies have demonstrated the effectiveness and safety of antiemetic therapy in pregnancy. However, fear of teratogenicity and lack of clinical guidelines lead to trial and error NVP management. We present an updated algorithm for the management of NVP. FAU - Shtomo, Meital AU - Shtomo M FAU - Cohen, Rana AU - Cohen R FAU - Berkovitch, Mati AU - Berkovitch M FAU - Koren, Gideon AU - Koren G LA - heb PT - English Abstract PT - Journal Article PT - Review PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 RN - 0 (Antiemetics) SB - IM MH - Antiemetics/adverse effects/*therapeutic use MH - Female MH - Hospitalization/statistics & numerical data MH - Humans MH - Hyperemesis Gravidarum/epidemiology/*therapy MH - Morning Sickness/epidemiology/*therapy MH - Pregnancy MH - Prevalence MH - Quality of Life MH - Severity of Illness Index EDAT- 2016/01/30 06:00 MHDA- 2016/02/13 06:00 CRDT- 2016/01/30 06:00 PHST- 2016/01/30 06:00 [entrez] PHST- 2016/01/30 06:00 [pubmed] PHST- 2016/02/13 06:00 [medline] PST - ppublish SO - Harefuah. 2015 Nov;154(11):720-4, 741. PMID- 25788220 OWN - NLM STAT- MEDLINE DCOM- 20160929 LR - 20181113 IS - 1436-2813 (Electronic) IS - 0941-1291 (Linking) VI - 46 IP - 2 DP - 2016 Feb TI - The safety and prognostic factors for mortality in extremely elderly patients undergoing an emergency operation. PG - 241-7 LID - 10.1007/s00595-015-1147-x [doi] AB - PURPOSE: As the number of elderly people has increased, the number of elderly patients who need emergency operations has also increased. Although there are many models to evaluate the risk of surgery in elderly patients, they all are associated with limitations. We herein evaluated the prognostic factors for surgical mortality in elderly patients more than 80 years old who needed emergency operations. METHODS: A total of 171 patients more than 80 years old underwent emergency operations from January 2001 to December 2012. Among them, 79 patients with acute cholecystitis, panperitonitis and intestinal obstruction with strangulation, which included mortality cases, were included. We retrospectively reviewed the medical records of the patients and analyzed the prognostic factors for surgical mortality. RESULTS: Forty-eight patients had a co-morbidity. Thirty-one patients initially had systemic inflammatory response syndrome. There were 27 surgical mortality cases. A univariate analysis revealed that panperitonitis, a positive blood culture and the level of albumin were significant prognostic factors predicting a worse prognosis. However, a multivariate analysis revealed that a serum albumin level more than 3.5 g/dL was the only significant prognostic factor (p = 0.037). CONCLUSION: Surgeons cannot fully evaluate the risk of emergency operation cases. However, our data indicate that if patients do not show hypoalbuminemia, the surgeon may be able to perform an emergency operation without a high risk of surgical mortality. FAU - Park, Seon-Young AU - Park SY AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. FAU - Chung, Jae Sik AU - Chung JS AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. FAU - Kim, Sung Hoon AU - Kim SH AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. drgs01@yonsei.ac.kr. FAU - Kim, Young Wan AU - Kim YW AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. FAU - Ryu, Hoon AU - Ryu H AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. FAU - Kim, Dong Hyun AU - Kim DH AD - Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, 162, Ilsan-dong, Wonju, Gangwon-Do, 220-701, Korea. LA - eng PT - Journal Article DEP - 20150319 PL - Japan TA - Surg Today JT - Surgery today JID - 9204360 SB - IM MH - Acute Disease MH - Age Factors MH - Aged, 80 and over MH - Cholecystitis/mortality/surgery MH - Emergencies/epidemiology MH - Female MH - Humans MH - Hypoalbuminemia MH - Intestinal Obstruction/mortality/surgery MH - Male MH - Peritonitis/mortality/surgery MH - Prognosis MH - Retrospective Studies MH - Risk MH - Safety MH - Surgical Procedures, Operative/*mortality OTO - NOTNLM OT - Albumin OT - Emergency OT - Geriatrics OT - Surgery EDAT- 2015/03/20 06:00 MHDA- 2016/09/30 06:00 CRDT- 2015/03/20 06:00 PHST- 2014/10/29 00:00 [received] PHST- 2015/01/20 00:00 [accepted] PHST- 2015/03/20 06:00 [entrez] PHST- 2015/03/20 06:00 [pubmed] PHST- 2016/09/30 06:00 [medline] AID - 10.1007/s00595-015-1147-x [pii] AID - 10.1007/s00595-015-1147-x [doi] PST - ppublish SO - Surg Today. 2016 Feb;46(2):241-7. doi: 10.1007/s00595-015-1147-x. Epub 2015 Mar 19. PMID- 9932754 OWN - NLM STAT- MEDLINE DCOM- 19990331 LR - 20141120 IS - 0013-726X (Print) IS - 0013-726X (Linking) VI - 30 IP - 9 DP - 1998 Nov TI - Safety and feasibility of a new minimally invasive diagnostic laparoscopy technique. PG - 756-62 AB - BACKGROUND AND STUDY AIMS: Laparoscopy combined with guided liver biopsy offers many advantages in the diagnosis and staging of chronic liver diseases and is superior to other diagnostic procedures. We developed a new minilaparoscopic technique and evaluated the utility of this minimally invasive laparoscopic system in the first 320 patients who underwent diagnostic assessment for liver disease or peritoneal carcinosis. PATIENTS AND METHODS: Between July 1996 and February 1998, minilaparoscopy, with analgesia and sedation was carried out in 320 patients. It was done using a 1.9-mm optical instrument, which was inserted through the same 2.75-mm trocar as the Veress needle used for inflating the pneumoperitoneum. Thus only a single puncture of the peritoneum was required. Liver biopsies, when indicated, were obtained under laparoscopic control with the Silverman needle through a short 2-mm additional trocar when the Menghini technique was used. RESULTS: Complication rates, patient discomfort and duration of procedure were extremely low with minilaparoscopy. We observed no serious complications, two complications that could be treated conservatively and technical difficulties in eight of 320 patients, which prevented liver biopsy in 2.8%. These minor difficulties all happened during the first 40 procedures, whereas after the initial 40 examinations of each investigator no further difficulties arose. CONCLUSIONS: This new minilaparoscopic technique allows a macroscopic and histological diagnosis of liver disease with minimal invasiveness, easy handling, excellent patient tolerance, and also a high degree of safety in patients with coagulation defects. Exploratory laparoscopy is an accurate and safe method for intra-abdominal diagnosis of liver diseases and peritoneal carcinosis. FAU - Helmreich-Becker, I AU - Helmreich-Becker I AD - I. Dept. of Medicine, Johannes Gutenberg University Mainz, Germany. FAU - Meyer zum Büschenfelde, K H AU - Meyer zum Büschenfelde KH FAU - Lohse, A W AU - Lohse AW LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PL - Germany TA - Endoscopy JT - Endoscopy JID - 0215166 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Biopsy MH - Child MH - Child, Preschool MH - Chronic Disease MH - Diagnosis, Differential MH - Feasibility Studies MH - Female MH - Follow-Up Studies MH - Humans MH - Laparoscopes MH - *Laparoscopy/standards MH - Liver/*pathology MH - Liver Diseases/*diagnosis MH - Male MH - Middle Aged MH - Minimally Invasive Surgical Procedures MH - Patient Satisfaction MH - Peritoneal Neoplasms/*diagnosis MH - Pneumoperitoneum, Artificial MH - Reproducibility of Results MH - Retrospective Studies MH - Safety EDAT- 1999/02/05 00:00 MHDA- 1999/02/05 00:01 CRDT- 1999/02/05 00:00 PHST- 1999/02/05 00:00 [pubmed] PHST- 1999/02/05 00:01 [medline] PHST- 1999/02/05 00:00 [entrez] AID - 10.1055/s-2007-1001417 [doi] PST - ppublish SO - Endoscopy. 1998 Nov;30(9):756-62. doi: 10.1055/s-2007-1001417. PMID- 39726419 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 1664-462X (Print) IS - 1664-462X (Electronic) IS - 1664-462X (Linking) VI - 15 DP - 2024 TI - Unlocking the role of silicon against biotic stress in plants. PG - 1430804 LID - 10.3389/fpls.2024.1430804 [doi] LID - 1430804 AB - The requirement for agricultural crops continues to enhance with the continuous growth of the human population globally. Plant pathogenic diseases outbreaks are enhancing and threatening food security and safety for the vulnerable in different regions worldwide. Silicon (Si) is considered a non-essential element for plant growth. It regulates the biological functions, plant development and productivity, and balance the defense mechanism in response to fungal, bacterial and pest attacks. The optimum crop yield can be achieved by applying Si in agricultural systems through different methods to replace or minimize the use of synthetic fertilizers. This approach can be effective on crop production during limited resources, extreme climates, pests and diseases, and environmental pollution. Silicon can be applied as foliar spray, priming of seeds, soil water irrigation, soil amendment and soilless medium (hydroponic) to enhance plant performance and stress tolerance capacity during stress conditions. This article summarized the effective roles of Si and the ability to perform in agroecosystems for better crop production, food security and safety for sustainable agriculture in the future. CI - Copyright © 2024 Verma, Song, Liang, Huang, Bhatt, Xu, Chen and Li. FAU - Verma, Krishan K AU - Verma KK AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. FAU - Song, Xiu-Peng AU - Song XP AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. FAU - Liang, Qiang AU - Liang Q AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. FAU - Huang, Hai-Rong AU - Huang HR AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. FAU - Bhatt, Rajan AU - Bhatt R AD - Punjab Agricultural University (PAU)-Krishi Vigyan Kendra Amritsar, Punjab, India. FAU - Xu, Lin AU - Xu L AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. FAU - Chen, Gan-Lin AU - Chen GL AD - Guangxi Subtropical Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning, Guangxi, China. AD - Guangxi Key Laboratory of Quality and Safety Control for Subtropical Fruits, Ministry of Agriculture and Rural Affairs, Nanning, Guangxi, China. AD - Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable, Ministry of Agriculture and Rural Affairs, Nanning, Guangxi, China. AD - School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, Guangxi, China. FAU - Li, Yang-Rui AU - Li YR AD - Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences/Key Laboratory of Sugarcane Biotechnology and Genetic Improvement, Ministry of Agriculture and Rural Affairs/Guangxi Key Laboratory of Sugarcane Genetic Improvement, Nanning, Guangxi, China. LA - eng PT - Journal Article PT - Review DEP - 20241212 PL - Switzerland TA - Front Plant Sci JT - Frontiers in plant science JID - 101568200 PMC - PMC11670751 OTO - NOTNLM OT - crop productivity OT - disease tolerance efficiency and management OT - pathogenic diseases OT - plant nutrition OT - silicon COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/12/27 06:20 MHDA- 2024/12/27 06:21 PMCR- 2024/01/01 CRDT- 2024/12/27 03:53 PHST- 2024/05/10 00:00 [received] PHST- 2024/11/25 00:00 [accepted] PHST- 2024/12/27 06:21 [medline] PHST- 2024/12/27 06:20 [pubmed] PHST- 2024/12/27 03:53 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fpls.2024.1430804 [doi] PST - epublish SO - Front Plant Sci. 2024 Dec 12;15:1430804. doi: 10.3389/fpls.2024.1430804. eCollection 2024. PMID- 16827689 OWN - NLM STAT- MEDLINE DCOM- 20070104 LR - 20220318 IS - 0909-752X (Print) IS - 0909-752X (Linking) VI - 12 IP - 3 DP - 2006 Aug TI - Safety of sodium fluorescein for in vivo study of skin. PG - 155-61 AB - BACKGROUND/PURPOSE: Epicutaneous labeling or intradermal injection of the fluorescent sodium fluorescein is being used increasingly to investigate skin conditions in vivo when using non-invasive devices such as confocal scanning laser microscopy. Sodium fluorescein was used intravenously for decades for the examination of the vasculature of the ocular fundus (fluorescein angiography) and as eye drops for diagnosis of corneal erosions. The objective of this article is to systematically review the literature on fluorescein and conclude its safety in cutaneous research to support research planning and evaluations by ethics committees. METHODS: A number of databases and the literature about safety and toxicity of fluorescein in animal and human studies were searched and analyzed. RESULTS: Side effects or adverse events reported in the literature were related to intravenous bolus injection. Transient nausea and vomiting may occur. Other adverse events such as vasovagal reaction, cardiac or respiratory effects and anaphylaxes are extremely rare but may be fatal. Intradermal injection may cause mild itch or pain; systemic adverse event was reported. Epicutaneous labeling is associated with no reported problem. A typical local dose is several magnitudes of order smaller than a typical intravenous dose. CONCLUSION: Fluorescein has been used for many years in medicine for diagnostic purposes and is widely safe, albeit intravenous bolus injection may cause serious adverse reactions. In the literature, we could not trace reports of local or systemic side effects of topical sodium fluorescein except itch and pain on intradermal injection, however, dependent on the fluorescein preparation used. Local dermal application of fluorescein for in vivo study of skin may be considered widely safe. FAU - O'goshi, Ken-ichiro AU - O'goshi K AD - Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark. kenmockjp@yahoo.co.jp FAU - Serup, Jørgen AU - Serup J LA - eng PT - Journal Article PT - Review PL - England TA - Skin Res Technol JT - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) JID - 9504453 RN - TPY09G7XIR (Fluorescein) SB - IM MH - Administration, Oral MH - Fluorescein/administration & dosage/*adverse effects/pharmacokinetics MH - Humans MH - Injections, Intravenous MH - Injections, Spinal MH - Safety MH - Skin/*drug effects RF - 46 EDAT- 2006/07/11 09:00 MHDA- 2007/01/05 09:00 CRDT- 2006/07/11 09:00 PHST- 2006/07/11 09:00 [pubmed] PHST- 2007/01/05 09:00 [medline] PHST- 2006/07/11 09:00 [entrez] AID - SRT147 [pii] AID - 10.1111/j.0909-752X.2006.00147.x [doi] PST - ppublish SO - Skin Res Technol. 2006 Aug;12(3):155-61. doi: 10.1111/j.0909-752X.2006.00147.x. PMID- 24727436 OWN - NLM STAT- MEDLINE DCOM- 20150128 LR - 20161125 IS - 1361-6498 (Electronic) IS - 0952-4746 (Linking) VI - 34 IP - 2 DP - 2014 Jun TI - The siting of UK nuclear reactors. PG - R1-24 LID - 10.1088/0952-4746/34/2/R1 [doi] AB - Choosing a suitable site for a nuclear power station requires the consideration and balancing of several factors. Some 'physical' site characteristics, such as the local climate and the potential for seismic activity, will be generic to all reactors designs, while others, such as the availability of cooling water, the area of land required and geological conditions capable of sustaining the weight of the reactor and other buildings will to an extent be dependent on the particular design of reactor chosen (or alternatively the reactor design chosen may to an extent be dependent on the characteristics of an available site). However, one particularly interesting tension is a human and demographic one. On the one hand it is beneficial to place nuclear stations close to centres of population, to reduce transmission losses and other costs (including to the local environment) of transporting electricity over large distances from generator to consumer. On the other it is advantageous to place nuclear stations some distance away from such population centres in order to minimise the potential human consequences of a major release of radioactive materials in the (extremely unlikely) event of a major nuclear accident, not only in terms of direct exposure but also concerning the management of emergency planning, notably evacuation.This paper considers the emergence of policies aimed at managing this tension in the UK. In the first phase of nuclear development (roughly speaking 1945-1965) there was a highly cautious attitude, with installations being placed in remote rural locations with very low population density. The second phase (1965-1985) saw a more relaxed approach, allowing the development of AGR nuclear power stations (which with concrete pressure vessels were regarded as significantly safer) closer to population centres (in 'semi-urban' locations, notably at Hartlepool and Heysham). In the third phase (1985-2005) there was very little new nuclear development, Sizewell B (the first and so far only PWR power reactor in the UK) being colocated with an early Magnox station on the rural Suffolk coast. Renewed interest in nuclear new build from 2005 onward led to a number of sites being identified for new reactors before 2025, all having previously hosted nuclear stations and including the semi-urban locations of the 1960s and 1970s. Finally, some speculative comments are made as to what a 'fifth phase' starting in 2025 might look like. FAU - Grimston, Malcolm AU - Grimston M AD - Imperial College Centre for Energy Policy and Technology, 14 Princes Gardens, London SW7 2AZ, UK. FAU - Nuttall, William J AU - Nuttall WJ FAU - Vaughan, Geoff AU - Vaughan G LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20140414 PL - England TA - J Radiol Prot JT - Journal of radiological protection : official journal of the Society for Radiological Protection JID - 8809257 SB - IM CIN - J Radiol Prot. 2014 Sep;34(3):717-8. doi: 10.1088/0952-4746/34/3/717. PMID: 25176988 CIN - J Radiol Prot. 2014 Sep;34(3):719. doi: 10.1088/0952-4746/34/3/719. PMID: 25176989 MH - *Decision Making MH - Facility Design and Construction/*methods MH - *Nuclear Reactors MH - Radiation Protection/*methods MH - Radioactive Hazard Release/*prevention & control MH - Safety Management/*organization & administration MH - Spatio-Temporal Analysis MH - United Kingdom EDAT- 2014/04/15 06:00 MHDA- 2015/01/30 06:00 CRDT- 2014/04/15 06:00 PHST- 2014/04/15 06:00 [entrez] PHST- 2014/04/15 06:00 [pubmed] PHST- 2015/01/30 06:00 [medline] AID - 10.1088/0952-4746/34/2/R1 [doi] PST - ppublish SO - J Radiol Prot. 2014 Jun;34(2):R1-24. doi: 10.1088/0952-4746/34/2/R1. Epub 2014 Apr 14. PMID- 37688224 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230911 IS - 2073-4360 (Electronic) IS - 2073-4360 (Linking) VI - 15 IP - 17 DP - 2023 Aug 30 TI - Performance Characteristics of Silicone Rubber for Use in Acidic Environments. LID - 10.3390/polym15173598 [doi] LID - 3598 AB - Silicone rubber insulators are widely used in power grids because of their excellent performance, but aging has been an inevitable problem of silicone rubber, especially in extreme conditions, such as acidic conditions. In order to clarify the performance changes in silicone rubber in an acidic environment, this paper uses the developed acid-resistant silicone rubber sheet and common silicone rubber samples as the research objects, and conducts an aging comparison test on them in a natural acidic environment. The electrical properties, physical properties, and chemical properties of the two types of silicone rubber specimens with different aging times are analyzed to obtain the performance characteristics of silicone rubber under a natural acidic environment. The research results show that the dry flash voltage and pollution flashover voltage of the acid-resistant silicone rubber after one year of aging are greater than those of the common type; the water repellency of both types of silicone rubber remains in good condition. The silicone rubber produced by our team according to the self-developed acid-resistant silicone rubber formula has indeed played a role in delaying aging in an acidic environment compared with the common-type silicone rubber. FAU - Zhang, Zhijin AU - Zhang Z AD - Xuefeng Mountain Energy Equipment Safety National Observation and Research Station, Chongqing University, Chongqing 400044, China. FAU - Zhang, Zhiqin AU - Zhang Z AD - Xuefeng Mountain Energy Equipment Safety National Observation and Research Station, Chongqing University, Chongqing 400044, China. FAU - Yue, Song AU - Yue S AD - Xuefeng Mountain Energy Equipment Safety National Observation and Research Station, Chongqing University, Chongqing 400044, China. FAU - Jiang, Xingliang AU - Jiang X AD - Xuefeng Mountain Energy Equipment Safety National Observation and Research Station, Chongqing University, Chongqing 400044, China. FAU - Hu, Jianlin AU - Hu J AD - Xuefeng Mountain Energy Equipment Safety National Observation and Research Station, Chongqing University, Chongqing 400044, China. LA - eng GR - 52077018/the National Natural Science Foundation of China/ PT - Journal Article DEP - 20230830 PL - Switzerland TA - Polymers (Basel) JT - Polymers JID - 101545357 PMC - PMC10489667 OTO - NOTNLM OT - acid-resistant silicone rubber OT - acidic environment OT - composite insulators OT - performance characteristics OT - silicone rubber COIS- The authors declare no conflict of interest. EDAT- 2023/09/09 11:42 MHDA- 2023/09/09 11:43 PMCR- 2023/08/30 CRDT- 2023/09/09 01:24 PHST- 2023/08/07 00:00 [received] PHST- 2023/08/25 00:00 [revised] PHST- 2023/08/28 00:00 [accepted] PHST- 2023/09/09 11:43 [medline] PHST- 2023/09/09 11:42 [pubmed] PHST- 2023/09/09 01:24 [entrez] PHST- 2023/08/30 00:00 [pmc-release] AID - polym15173598 [pii] AID - polymers-15-03598 [pii] AID - 10.3390/polym15173598 [doi] PST - epublish SO - Polymers (Basel). 2023 Aug 30;15(17):3598. doi: 10.3390/polym15173598. PMID- 27974738 OWN - NLM STAT- MEDLINE DCOM- 20170406 LR - 20170406 IS - 1738-8872 (Electronic) IS - 1017-7825 (Linking) VI - 27 IP - 3 DP - 2017 Mar 28 TI - Significance of Viable but Nonculturable Escherichia coli: Induction, Detection, and Control. PG - 417-428 LID - 10.4014/jmb.1609.09063 [doi] AB - Diseases caused by foodborne or waterborne pathogens are emerging. Many pathogens can enter into the viable but nonculturable (VBNC) state, which is a survival strategy when exposed to harsh environmental stresses. Pathogens in the VBNC state have the ability to evade conventional microbiological detection methods, posing a significant and potential health risk. Therefore, controlling VBNC bacteria in food processing and the environment is of great importance. As the typical one of the gram-negatives, Escherichia coli (E. coli) is a widespread foodborne and waterborne pathogenic bacterium and is able to enter into a VBNC state in extreme conditions (similar to the other gram-negative bacteria), including inducing factors and resuscitation stimulus. VBNC E. coli has the ability to recover both culturability and pathogenicity, which may bring potential health risk. This review describes the concrete factors (nonthermal treatment, chemical agents, and environmental factors) that induce E. coli into the VBNC state, the condition or stimulus required for resuscitation of VBNC E. coli, and the methods for detecting VBNC E. coli. Furthermore, the mechanism of genes and proteins involved in the VBNC E. coli is also discussed in this review. FAU - Ding, Tian AU - Ding T AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. FAU - Suo, Yuanjie AU - Suo Y AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. FAU - Xiang, Qisen AU - Xiang Q AD - College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, P.R. China. FAU - Zhao, Xihong AU - Zhao X AD - Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430073, P.R. China. FAU - Chen, Shiguo AU - Chen S AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. FAU - Ye, Xingqian AU - Ye X AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. FAU - Liu, Donghong AU - Liu D AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China. LA - eng PT - Journal Article PT - Review PL - Korea (South) TA - J Microbiol Biotechnol JT - Journal of microbiology and biotechnology JID - 9431852 RN - 0 (Virulence Factors) SB - IM MH - Animals MH - Bacterial Typing Techniques MH - Communicable Disease Control/methods MH - Environmental Microbiology MH - Escherichia coli/*classification/*physiology MH - Escherichia coli Infections/epidemiology/microbiology/prevention & control/transmission MH - Food Microbiology MH - Food Safety MH - Humans MH - *Microbial Viability MH - Risk MH - Virulence/genetics MH - Virulence Factors/genetics OTO - NOTNLM OT - Escherichia coli OT - detection methods OT - mechanism OT - resuscitation OT - viable but nonculturable state EDAT- 2016/12/16 06:00 MHDA- 2017/04/07 06:00 CRDT- 2016/12/16 06:00 PHST- 2016/12/16 06:00 [pubmed] PHST- 2017/04/07 06:00 [medline] PHST- 2016/12/16 06:00 [entrez] AID - 10.4014/jmb.1609.09063 [pii] AID - 10.4014/jmb.1609.09063 [doi] PST - ppublish SO - J Microbiol Biotechnol. 2017 Mar 28;27(3):417-428. doi: 10.4014/jmb.1609.09063. PMID- 19481687 OWN - NLM STAT- MEDLINE DCOM- 20090819 LR - 20131121 IS - 1873-3476 (Electronic) IS - 0378-5173 (Linking) VI - 375 IP - 1-2 DP - 2009 Jun 22 TI - Adhesiveness of a new testosterone-in-adhesive matrix patch after extreme conditions. PG - 28-32 LID - 10.1016/j.ijpharm.2009.03.025 [doi] AB - The objective of the study was to evaluate the adhesiveness of a new thin, transparent and comfortable testosterone-in-adhesive matrix patch, Testopatch, after extreme conditions. The study was a single-centre, open-label with randomization of sites (upper arms, lower back, thighs) and sides (left, right) of two 45 cm(2) patches, in 24 healthy subjects. Patches were symmetrically applied on one of the three sites. One patch was removed after 2.0 h, under resting conditions and the other patch was removed at 3.5 h, after extreme conditions (physical exercise, sauna, whirl bath). Adhesiveness was assessed of the area stuck and the measure of the forces necessary for patch removal using a Peel Patch Tester. Local safety was assessed at 2.0 and 3.5 h. After physical exercise and after sauna, patch adhesiveness was excellent (95%) when applied on the thigh and very good (90%) on the upper arm. Forces of patch removal were significantly lower at 3.5 h than 2.0 h, and at the lower back compared to the other application sites. There were no adverse effects. Slight erythema was observed that was considered to be clinically insignificant. Testopatch was safe and displayed adhesiveness, compatible with physical activities. FAU - Raynaud, Jean-Pierre AU - Raynaud JP AD - Université Pierre et Marie Curie, 4 place Jussieu, 51 Bd Suchet, 75252 Paris Cedex 05, 75016 Paris, France. jeanpierre@raynaud.ws FAU - Augès, Marie AU - Augès M FAU - Liorzou, Laurent AU - Liorzou L FAU - Turlier, Virginie AU - Turlier V FAU - Lauze, Christophe AU - Lauze C LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20090401 PL - Netherlands TA - Int J Pharm JT - International journal of pharmaceutics JID - 7804127 RN - 0 (Adhesives) RN - 0 (Androgens) RN - 3XMK78S47O (Testosterone) SB - IM MH - Adhesiveness MH - *Adhesives MH - Administration, Cutaneous MH - Adult MH - Androgens/*administration & dosage/adverse effects MH - Arm MH - Back MH - Drug Delivery Systems MH - Erythema/etiology MH - Exercise MH - Humans MH - Male MH - Steam Bath MH - Testosterone/*administration & dosage/adverse effects MH - Thigh MH - Time Factors MH - Young Adult EDAT- 2009/06/02 09:00 MHDA- 2009/08/20 09:00 CRDT- 2009/06/02 09:00 PHST- 2008/11/27 00:00 [received] PHST- 2009/03/12 00:00 [revised] PHST- 2009/03/20 00:00 [accepted] PHST- 2009/06/02 09:00 [entrez] PHST- 2009/06/02 09:00 [pubmed] PHST- 2009/08/20 09:00 [medline] AID - S0378-5173(09)00169-0 [pii] AID - 10.1016/j.ijpharm.2009.03.025 [doi] PST - ppublish SO - Int J Pharm. 2009 Jun 22;375(1-2):28-32. doi: 10.1016/j.ijpharm.2009.03.025. Epub 2009 Apr 1. PMID- 21315975 OWN - NLM STAT- MEDLINE DCOM- 20110324 LR - 20111104 IS - 1095-9998 (Electronic) IS - 0740-0020 (Linking) VI - 28 IP - 2 DP - 2011 Apr TI - Challenges in risk assessment and predictive microbiology of foodborne spore-forming bacteria. PG - 209-13 LID - 10.1016/j.fm.2010.05.003 [doi] AB - Mathematical description of the behavior of bacterial foodborne pathogens and concepts of risk assessment were first applied to spore-forming bacteria and specially to Clostridium botulinum with numerous works dealing with spores heat destruction to ensure the safety of canned foods or with their germination and growth probability in foods. This paper discusses two aspects which appear specific to pathogenic sporeformers in comparison to vegetative microorganisms, that is, firstly, the extreme intra-species biodiversity of spore-forming bacteria and its consequences for risk assessment and, secondly, the modeling of spore germination and outgrowth processes. The intra-species biodiversity of spore-forming bacteria has a great impact on hazard identification, exposure assessment and hazard characterization leading thus to an extremely variable individual poisoning risk for consumers. The germination and outgrowth processes were shown independent at the single cell level and although numerous studies were performed to study the effect of spores treatments and growth conditions on these two events, the mathematical modeling and the prediction of these processes is still challenging today. The difficulties to accurately assess the biodiversity and the germination and outgrowth processes of spore-forming bacteria lead to a substantial uncertainty in risk estimates related to the exposure to these microorganisms. Nevertheless, significant progress have been made these last years improving the relevance of quantitative risk assessments for spore-forming bacteria and decreasing the risk uncertainty. Despite these difficulties, risk assessment still constitutes a valuable tool to justify the implementation of management options. CI - Copyright © 2010 Elsevier Ltd. All rights reserved. FAU - Augustin, Jean-Christophe AU - Augustin JC AD - Ecole Nationale Vétérinaire d'Alfort, Unité Microbiologie des Aliments, Sécurité et Qualité (MASQ), 7 avenue du Général de Gaulle, F-94704 Maisons-Alfort Cedex, France. jcaugustin@vet-alfort.fr LA - eng PT - Journal Article PT - Review DEP - 20100508 PL - England TA - Food Microbiol JT - Food microbiology JID - 8601127 SB - IM MH - Clostridium botulinum/growth & development/*physiology MH - Colony Count, Microbial MH - *Consumer Product Safety MH - *Food Microbiology MH - Humans MH - Models, Biological MH - Population Dynamics MH - Predictive Value of Tests MH - *Risk Assessment MH - Species Specificity MH - Spores, Bacterial/*growth & development EDAT- 2011/02/15 06:00 MHDA- 2011/03/25 06:00 CRDT- 2011/02/15 06:00 PHST- 2009/12/15 00:00 [received] PHST- 2010/05/01 00:00 [revised] PHST- 2010/05/03 00:00 [accepted] PHST- 2011/02/15 06:00 [entrez] PHST- 2011/02/15 06:00 [pubmed] PHST- 2011/03/25 06:00 [medline] AID - S0740-0020(10)00094-8 [pii] AID - 10.1016/j.fm.2010.05.003 [doi] PST - ppublish SO - Food Microbiol. 2011 Apr;28(2):209-13. doi: 10.1016/j.fm.2010.05.003. Epub 2010 May 8. PMID- 33139128 OWN - NLM STAT- MEDLINE DCOM- 20210924 LR - 20231213 IS - 0398-7620 (Print) IS - 0398-7620 (Linking) VI - 68 IP - 6 DP - 2020 Nov TI - Disparate exposure to physically demanding working conditions in France. PG - 327-336 LID - S0398-7620(20)30466-1 [pii] LID - 10.1016/j.respe.2020.09.008 [doi] AB - BACKGROUND: Our study was aimed at examining disparate exposure to physically demanding working conditions in France, a key objective being to identify the types of employees/jobs requiring high-priority preventive actions. METHODS: We analyzed the data from the 2017 French nationwide cross-sectional survey (SUMER) on occupational hazards to which French employees in various sectors were subjected. The prevalence of several types of physically demanding working conditions (lifting of heavy loads, awkward body postures, vibrations, noise, and extreme temperatures) was explored. Potential associations of individual and job characteristics with these factors of hardship at work were studied by multivariate logistic regression. RESULTS: In total, 48% of employees were exposed to at least one physically demanding working condition and 24.8% were exposed to multiple constraints. While managers and intellectual professionals were exposed relatively infrequently to physical constraints, blue-collar workers experienced the highest frequency of exposure. On the one hand, the role of company size depended on the factor of hardship at work considered; on the other hand, employees in large-scale companies were generally less exposed. As expected, employees in the construction industry were the most exposed to physical constraints; that said, our results also show that some activities in the services sector (e.g., personal care, administrative and support services) were quite significantly affected by a wide array of physically demanding working conditions. CONCLUSION: Notwithstanding the establishment in France of Plans de Santé au travail (preventive workplace health and safety plans), occupational risks were found to be high, and above all, they were unevenly distributed among the various socio-professional categories, and strongly contributed to social inequalities in health. Our results identify the types of publics to be designated as high-priority targets for preventive measures aimed at reducing the adverse impacts of physically demanding working conditions and the incidence of associated musculoskeletal disorders. CI - Copyright © 2020 Elsevier Masson SAS. All rights reserved. FAU - Havet, N AU - Havet N AD - Laboratoire SAF, ISFA, université de Lyon, université Claude-Bernard Lyon 1, 50, avenue Tony-Garnier, 69007 Lyon cedex, France. Electronic address: nathalie.havet@univ-lyon1.fr. FAU - Fournier, J AU - Fournier J AD - Laboratoire SAF, ISFA, université de Lyon, université Claude-Bernard Lyon 1, 50, avenue Tony-Garnier, 69007 Lyon cedex, France. Electronic address: jordan.fournier@etu.univ-lyon1.fr. FAU - Stefanelli, J AU - Stefanelli J AD - Laboratoire SAF, ISFA, université de Lyon, université Claude-Bernard Lyon 1, 50, avenue Tony-Garnier, 69007 Lyon cedex, France. Electronic address: jordan.stefanelli@etu.univ-lyon1.fr. FAU - Plantier, M AU - Plantier M AD - Laboratoire SAF, ISFA, université de Lyon, université Claude-Bernard Lyon 1, 50, avenue Tony-Garnier, 69007 Lyon cedex, France. Electronic address: morgane.plantier@univ-lyon1.fr. FAU - Penot, A AU - Penot A AD - GATE - UMR 5824-CNRS, ENS Lyon, université de Lyon, 15, parvis René-Descartes, BP 7000, 69342 Lyon cedex 07, France. Electronic address: alexis.penot@ens-lyon.fr. LA - eng PT - Journal Article DEP - 20201031 PL - France TA - Rev Epidemiol Sante Publique JT - Revue d'epidemiologie et de sante publique JID - 7608039 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Cross-Sectional Studies MH - Extreme Cold/adverse effects MH - Extreme Heat/adverse effects MH - Female MH - France/epidemiology MH - *Health Status Disparities MH - Humans MH - Male MH - Middle Aged MH - Noise, Occupational/statistics & numerical data MH - Occupational Diseases/epidemiology MH - Occupational Exposure/*statistics & numerical data MH - Occupations/statistics & numerical data MH - Posture MH - Prevalence MH - Risk Factors MH - Shift Work Schedule/statistics & numerical data MH - Surveys and Questionnaires MH - Vibration MH - Workload/statistics & numerical data MH - Workplace/statistics & numerical data MH - Young Adult OTO - NOTNLM OT - Awkward body postures OT - Bruit nocif OT - Conditions de travail physique OT - Expositions professionnelles OT - Harmful noise OT - Health inequalities OT - Inégalités de santé OT - Occupational exposure OT - Physical workload OT - Physically demanding working conditions OT - Port de charges OT - Postures pénibles EDAT- 2020/11/04 06:00 MHDA- 2021/09/25 06:00 CRDT- 2020/11/03 05:36 PHST- 2019/11/25 00:00 [received] PHST- 2020/09/29 00:00 [revised] PHST- 2020/09/30 00:00 [accepted] PHST- 2020/11/04 06:00 [pubmed] PHST- 2021/09/25 06:00 [medline] PHST- 2020/11/03 05:36 [entrez] AID - S0398-7620(20)30466-1 [pii] AID - 10.1016/j.respe.2020.09.008 [doi] PST - ppublish SO - Rev Epidemiol Sante Publique. 2020 Nov;68(6):327-336. doi: 10.1016/j.respe.2020.09.008. Epub 2020 Oct 31. PMID- 34016355 OWN - NLM STAT- MEDLINE DCOM- 20211203 LR - 20231213 IS - 0306-4565 (Print) IS - 0306-4565 (Linking) VI - 98 DP - 2021 May TI - Human physiological responses of exposure to extremely cold environments. PG - 102933 LID - S0306-4565(21)00100-5 [pii] LID - 10.1016/j.jtherbio.2021.102933 [doi] AB - Extremely cold events have occurred more frequently in the past few years. People exposed to extremely cold exposure could suffer the threats of human health and safety like cold stress and injury. This study aims to investigate human physiological responses of exposure to extremely cold environments and the moment of temperature step. The experiments of 12 subjects exposed to three different cold exposure conditions (-5 °C, -10 °C, -15 °C) were carried out in a climate chamber. Most critical physiological parameters, including the core temperature, local skin temperature, blood pressure, heart rate, respiration rate and blood oxygen saturation, were measured to evaluate human physiological responses. In the particular short term study, the results show that the local skin temperature and blood pressure are the most significant indexes for evaluating the risk of cold strain in extremely cold environment. The finger temperature is a critical index of hand and finger flexibility, and it will lead to serious injuries and reduced manual performance when exposed to below -5 °C for more than 20 min. The high physiological strain at the very beginning moment of cold exposure can significantly affect the ability to make correct judgment and action, and it is suggested that the personnel adapt for 3 min after entering into the extremely cold environment to stabilize physiological parameters and thus enhancing the safety and occupational performance. The experimental data of this study is also of great significance for the development and validation of thermophysiological models. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Wu, Jiansong AU - Wu J AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. Electronic address: jiansongwu@hotmail.com. FAU - Hu, Zhuqiang AU - Hu Z AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. FAU - Han, Zhaoxing AU - Han Z AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. FAU - Gu, Yin AU - Gu Y AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. FAU - Yang, Lin AU - Yang L AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. FAU - Sun, Boyang AU - Sun B AD - School of Emergency Management & Safety Engineering, China University of Mining and Technology, Beijing, 100083, China. LA - eng PT - Journal Article DEP - 20210403 PL - England TA - J Therm Biol JT - Journal of thermal biology JID - 7600115 RN - S88TT14065 (Oxygen) SB - IM MH - Adult MH - Blood Pressure MH - Body Temperature MH - *Extreme Cold MH - Fingers MH - Heart Rate MH - Humans MH - Male MH - Oxygen/blood MH - Respiratory Rate MH - Skin MH - Young Adult OTO - NOTNLM OT - Cold exposure OT - Cold strain OT - Core temperature OT - Extremely cold environment OT - Local skin temperature OT - Physiological responses EDAT- 2021/05/22 06:00 MHDA- 2021/12/15 06:00 CRDT- 2021/05/21 05:50 PHST- 2020/10/07 00:00 [received] PHST- 2021/02/27 00:00 [revised] PHST- 2021/03/29 00:00 [accepted] PHST- 2021/05/21 05:50 [entrez] PHST- 2021/05/22 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] AID - S0306-4565(21)00100-5 [pii] AID - 10.1016/j.jtherbio.2021.102933 [doi] PST - ppublish SO - J Therm Biol. 2021 May;98:102933. doi: 10.1016/j.jtherbio.2021.102933. Epub 2021 Apr 3. PMID- 22994520 OWN - NLM STAT- MEDLINE DCOM- 20130320 LR - 20120921 IS - 1557-8682 (Electronic) IS - 1527-0297 (Linking) VI - 13 IP - 3 DP - 2012 Sep TI - Termination of cardiopulmonary resuscitation in mountain rescue. PG - 200-8 AB - The aim was to establish scientifically supported recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue, which can be applied by physicians and nonphysicians. A literature search was performed; the results and recommendations were discussed among the authors, and finally approved by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM) in October 2011. 4166 abstracts were reviewed; of these, 96 were relevant for this article and are included in this literature review. In mountain rescue, CPR may be withheld or terminated in a patient with absent vital signs when the risk is unacceptable to the rescuer, the rescuer is exhausted or in extreme environments where CPR is not possible or any of the following apply: decapitation; truncal transection; whole body incinerated, decomposed, or frozen solid; avalanche victim in asystole with obstructed airway and burial time >35 min. Also, CPR may be terminated when all of the following criteria apply: unwitnessed loss of vital signs, no return of spontaneous circulation during 20 min of CPR, no shock advised at any time by AED or only asystole on ECG, and no hypothermia or other special circumstances warranting extended CPR. In situations where transport is not possible, mitigation of special circumstances is not possible, and further resuscitation is futile, CPR should be terminated. Medical directors of rescue teams should interpret these recommendations in the context of local conditions and laws, and create team-specific training and protocols for determining when to withhold and terminate CPR in a patient with absent vital signs. FAU - Paal, Peter AU - Paal P AD - Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria. peter.paal@uki.at FAU - Milani, Mario AU - Milani M FAU - Brown, Douglas AU - Brown D FAU - Boyd, Jeff AU - Boyd J FAU - Ellerton, John AU - Ellerton J LA - eng PT - Journal Article PT - Review PL - United States TA - High Alt Med Biol JT - High altitude medicine & biology JID - 100901183 SB - IM MH - Cardiopulmonary Resuscitation/ethics/*standards MH - Humans MH - *Mountaineering MH - Practice Guidelines as Topic MH - Rescue Work/ethics/*standards MH - Safety MH - Withholding Treatment EDAT- 2012/09/22 06:00 MHDA- 2013/03/21 06:00 CRDT- 2012/09/22 06:00 PHST- 2012/09/22 06:00 [entrez] PHST- 2012/09/22 06:00 [pubmed] PHST- 2013/03/21 06:00 [medline] AID - 10.1089/ham.2011.1096 [doi] PST - ppublish SO - High Alt Med Biol. 2012 Sep;13(3):200-8. doi: 10.1089/ham.2011.1096. PMID- 32697792 OWN - NLM STAT- MEDLINE DCOM- 20200930 LR - 20200930 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 15 IP - 7 DP - 2020 TI - Optimization of stimulation parameters for epi-retinal implant based on biosafety consideration. PG - e0236176 LID - 10.1371/journal.pone.0236176 [doi] LID - e0236176 AB - BACKGROUND: Optimizing stimulation protocol is essential for clinical application of retinal prosthesis. Elongating stimulation pulse width (~25ms /phase) has been proposed as an effective method to improve spatial resolution of epi-retinal implants. However, it is unknown whether longer stimulus pulse width will increase the risk of damaging the retina. In addition, with the advent of next generation retinal prosthesis featuring high-density microelectrode array, it is tempting to optimizing a single set of parameters for all electrodes instead of optimizing parameters of each electrode, but this approach raised biosafety concern. We sought to study the effect of stimulus pulse width on the response of retinal ganglion cells to electrical stimulation, and evaluate if the single parameter set approach was valid based on biosafety measures. METHODS: We stimulated mouse retina using biphasic pulse waveform generated by chosen electrodes (single or a 3x3 assembly) from multiple microelectrode arrays, recorded their action potentials and performed spike sorting. We tested various stimulus intensity with two fixed pulse width: a short one for 1 millisecond per phase, and a long one for 25 milliseconds per phase. All these assays were performed on two mouse models: the wildtype C57BL/6J mice and the photoreceptor degenerated rd10 mice. The action-potential-frequency vs stimulus amplitude profiles were plotted, and three parameters were extracted: the threshold (the lowest stimulus amplitude activating RGC units), safety-limit (stimulus amplitude that attenuated the firing rate to half of the maximum response), and the stimulation amplitude range (the difference between threshold and safety limit parameters). RESULTS: In single-electrode stimulation experiment, we found that on average 85% of the recorded units showed attenuated response to extreme stimulation; among those units, an average of 51% stopped responding during stimulation ramping and failed to recover after one-hour post-stimulation, indicating extreme stimulation can damage RGC units. Twenty-five-millisecond pulse stimulation significantly reduced safety-limit and stimulation-amplitude-range parameters of recorded RGC units compared to 1ms pulse stimulation. During stimulus amplitude ramping, the maximum proportion of responsive healthy RGC units was 51% on average in 25ms pulse condition, and 76% on average in 1ms pulse condition, indicating long pulse may inflict more strain on RGCs, and a significant amount of inappropriately stimulated RGCs always exist. The contrast of these proportions could be explained by the tight correlation between the threshold and safety-limit parameter in 25ms pulse condition. These results were corroborated by those from 3x3 array stimulation experiments. CONCLUSION: Base on a biosafety measure (RGCs' evoked firing rate in response to electrical stimulation), we proposed that longer stimulation pulse width could lead to reduced retinal response and thus highlighted the importance of carefully setting the stimulation amplitude in this case. Our results also suggested that optimizing a single set of parameters for all electrodes without individual tweaking always generated a significant amount of inappropriately stimulated RGCs, especially in the long pulse stimulation condition. FAU - Lu, Yijie AU - Lu Y AD - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. AD - Shenzhen Aier Eye Hospital, Shenzhen, China. FAU - Qin, Shan AU - Qin S AD - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. AD - Shenzhen Shekou People's Hospital, The Second Xiangya Hospital of Central South University Shenzhen Hospital, Shenzhen, China. FAU - Zhao, Lei AU - Zhao L AD - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. FAU - Yue, Lan AU - Yue L AD - Roski Eye Institute, University of Southern California, Los Angeles, California, United States of America. FAU - Wu, Tianzhun AU - Wu T AD - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. FAU - Qin, Bo AU - Qin B AD - Shenzhen Aier Eye Hospital, Shenzhen, China. FAU - Xu, Zhen AU - Xu Z AUID- ORCID: 0000-0002-5674-9067 AD - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200722 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Action Potentials/physiology MH - Animals MH - Containment of Biohazards/*methods MH - Electric Stimulation/instrumentation/*methods MH - Humans MH - Mice MH - Microelectrodes MH - Retinal Degeneration/*therapy MH - Retinal Ganglion Cells/*physiology MH - Time Factors MH - Visual Prosthesis/*adverse effects PMC - PMC7375526 COIS- The authors have declared that no competing interests exist. EDAT- 2020/07/23 06:00 MHDA- 2020/10/02 06:00 PMCR- 2020/07/22 CRDT- 2020/07/23 06:00 PHST- 2020/03/04 00:00 [received] PHST- 2020/06/30 00:00 [accepted] PHST- 2020/07/23 06:00 [entrez] PHST- 2020/07/23 06:00 [pubmed] PHST- 2020/10/02 06:00 [medline] PHST- 2020/07/22 00:00 [pmc-release] AID - PONE-D-20-06370 [pii] AID - 10.1371/journal.pone.0236176 [doi] PST - epublish SO - PLoS One. 2020 Jul 22;15(7):e0236176. doi: 10.1371/journal.pone.0236176. eCollection 2020. PMID- 36164521 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220928 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 8 IP - 9 DP - 2022 Sep TI - The influence of physician-nurse collaboration on patient safety culture. PG - e10649 LID - 10.1016/j.heliyon.2022.e10649 [doi] LID - e10649 AB - BACKGROUND: Many factors in health care organizations affect patients' safety, such as; multi-professional teamwork and collaboration. Physician-Nurse collaboration is the most crucial inter-professional collaboration in the health care system. Because these professionals are the closest to the patient and make most decisions related to patients' conditions, Physician-Nurse collaboration affects patients' health condition consequences, length of stay in health care facilities, patients' mortality, and the existence of medical errors. AIM OF THE STUDY: This study explores the relationship between physician-nurse collaboration and patient safety culture and compares patient safety culture levels between Jordanian hospitals from different sectors. In addition, examine differences in patient safety culture levels according to the position of health care providers (i.e., nurse managers, RN, and physicians). METHODS: A descriptive, cross-sectional design using a self-administered questionnaire was used for the current study. Data were collected between February and May of 2019. Four different hospital settings in Jordan (University, not-for-profit, private and governmental hospitals) were selected. In addition, we recruited a convenience sample representing registered nurses, nurse managers, and physicians at the selected hospitals. MEASUREMENTS: Three self-administered questionnaires were used to collect data for the current study: Demographic Data, Collaboration and Satisfaction About Care Decisions (CSACD), and Hospital Survey on Patient Safety Culture version 1.0 (HSOPS). DATA ANALYSIS: Data were screened for errors in data entry, outliers, or missing values. Data were normally distributed without extreme outliers. This study used descriptive statistics, the Pearson product-moment correlation, one-way ANOVA, and the Chi-square tests were used in this study. The level of significance (alpha value) is set at 0.05. RESULTS: showed that physician-nurse collaboration had a significant positive relationship with all patient safety culture levels (P < 0.01). In addition, the Pearson's product-moment correlation coefficient results indicated that all patient safety culture scores and subscales were positively and significantly correlated with physician-nurse collaboration (P < 0.01). Furthermore, the results of one-way ANOVA showed a statistically significant difference in the overall perception of patient safety culture according to the position of participants (P < 0.01). Moreover, Participants in Not-for-Profit Hospitals were more likely to report an 'excellent/very good' patient safety grade (P < 0.001) than in other hospitals. CONCLUSION: Physician-nurse collaboration positively impacts overall patient safety culture grades. Health care organization in Jordan has the potential to increase levels of patient safety cultures; however, to achieve this aim, there should be a stronger focus on building effective inter-professional collaboration and building a blame-free culture among healthcare providers, and these organizations should receive the needed support from health care leaders in the country. To help strengthen the health care system, raise patient safety culture levels, and improve quality. CI - © 2022 The Authors. FAU - Amarneh, Basil Hameed AU - Amarneh BH AD - Faculty of Nursing, Jordan University of Science and Technology, Irbid, Jordan. FAU - Al Nobani, Fatima AU - Al Nobani F AD - Faculty of Nursing, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20220916 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC9508511 OTO - NOTNLM OT - Collaboration OT - Jordan OT - Nurses OT - Patient safety OT - Patient safety culture OT - Physician OT - Physician-nurse collaboration COIS- The authors declare no conflict of interest. EDAT- 2022/09/28 06:00 MHDA- 2022/09/28 06:01 PMCR- 2022/09/16 CRDT- 2022/09/27 02:01 PHST- 2021/05/02 00:00 [received] PHST- 2021/12/20 00:00 [revised] PHST- 2022/08/08 00:00 [accepted] PHST- 2022/09/27 02:01 [entrez] PHST- 2022/09/28 06:00 [pubmed] PHST- 2022/09/28 06:01 [medline] PHST- 2022/09/16 00:00 [pmc-release] AID - S2405-8440(22)01937-5 [pii] AID - e10649 [pii] AID - 10.1016/j.heliyon.2022.e10649 [doi] PST - epublish SO - Heliyon. 2022 Sep 16;8(9):e10649. doi: 10.1016/j.heliyon.2022.e10649. eCollection 2022 Sep. PMID- 33221988 OWN - NLM STAT- MEDLINE DCOM- 20210121 LR - 20210121 IS - 1432-8798 (Electronic) IS - 0304-8608 (Linking) VI - 166 IP - 1 DP - 2021 Jan TI - Complete genome sequence of the extreme-pH-resistant Salmonella bacteriophage αα of the family Microviridae. PG - 325-329 LID - 10.1007/s00705-020-04880-4 [doi] AB - A novel Salmonella bacteriophage (phage), named αα, was the first reported member of the family Microviridae to exhibit tolerance to both extreme acidic and alkaline conditions (pH 2-12 for 1 h). Phage αα has a circular single-stranded DNA genome of 5,387 nt with a G+C content of 44.66%. A total of 11 putative gene products and no tRNA genes are encoded in the phage αα genome. Whole-genome sequence comparisons revealed that phage αα shares 95% identity with coliphage phiX174 and had a close evolutionary relationship to the phages NC1 and NC7. Phylogenetic analysis of the structural proteins of phage αα and 18 other phiX174-like phages showed that a phylogenetic tree based on protein B sequences had a topology similar to that obtained using whole genome sequences. In addition, variable sites in proteins F and G distributed on the surface of the mature capsid and the conserved protein J were probably involved in maintaining the structural integrity of the phage under extreme pH conditions. Our findings could open up new perspectives for identifying more extreme-pH-resistant phages and their structural proteins and understanding the mechanism of phage adaptation and evolution under extreme environmental stress. FAU - Li, Mengzhe AU - Li M AD - Food Safety Laboratory, Department of Food Science and Engineering, Ocean University of China, Qingdao, 266003, People's Republic of China. FAU - Lin, Hong AU - Lin H AD - Food Safety Laboratory, Department of Food Science and Engineering, Ocean University of China, Qingdao, 266003, People's Republic of China. FAU - Wang, Luokai AU - Wang L AD - Food Safety Laboratory, Department of Food Science and Engineering, Ocean University of China, Qingdao, 266003, People's Republic of China. FAU - Wang, Jingxue AU - Wang J AUID- ORCID: 0000-0001-6705-815X AD - Food Safety Laboratory, Department of Food Science and Engineering, Ocean University of China, Qingdao, 266003, People's Republic of China. snow@ouc.edu.cn. LA - eng GR - 31870166/National Natural Science Foundation of China/ GR - 32001834/National Natural Science Foundation of China/ GR - 2017GNC13108/Natural Science Foundation of Shandong Province/ PT - Journal Article DEP - 20201122 PL - Austria TA - Arch Virol JT - Archives of virology JID - 7506870 RN - 0 (DNA, Viral) SB - IM MH - Bacteriophages/*genetics MH - Base Composition/genetics MH - DNA, Viral/genetics MH - Genome, Viral/*genetics MH - Hydrogen-Ion Concentration MH - Microviridae/*genetics MH - Phylogeny MH - Salmonella Phages/*genetics MH - Whole Genome Sequencing/methods EDAT- 2020/11/23 06:00 MHDA- 2021/01/22 06:00 CRDT- 2020/11/22 20:43 PHST- 2020/08/16 00:00 [received] PHST- 2020/09/29 00:00 [accepted] PHST- 2020/11/23 06:00 [pubmed] PHST- 2021/01/22 06:00 [medline] PHST- 2020/11/22 20:43 [entrez] AID - 10.1007/s00705-020-04880-4 [pii] AID - 10.1007/s00705-020-04880-4 [doi] PST - ppublish SO - Arch Virol. 2021 Jan;166(1):325-329. doi: 10.1007/s00705-020-04880-4. Epub 2020 Nov 22. PMID- 17190391 OWN - NLM STAT- MEDLINE DCOM- 20070208 LR - 20061227 IS - 0010-6178 (Print) IS - 0010-6178 (Linking) VI - 70 IP - 10 DP - 2006 Nov-Dec TI - Optimizing the medical management of diabetic patients undergoing surgery. PG - 621-30 AB - Patients with diabetes are prone to metabolic derangements because of their lack of effective insulin. Comorbid conditions, such as coronary artery disease, nephropathy, and autonomic neuropathy warrant preoperative assessment to ensure safety in the perioperative period. Preoperative evaluation must include assessment of chronic complications of diabetes. A thorough history and physical should guide preoperative testing which should be aimed at detecting correctable abnormalities and assessing the extent of end-organ disease. Surgery poses special challenges to patients with diabetes because the stress response, interruption of food intake, altered consciousness, and circulatory alterations all lead to unpredictable glucose and electrolyte levels. The management of insulin perioperatively depends on the preparation normally taken by the patient, and the glucose level on the morning of surgery. The goal is to avoid hypoglycemia and extreme hyperglycemia. Oral hypoglycemic agents should be held on the morning of surgery. Metformin should be discontinued 48 hours prior to and subsequent to surgery in order to reduce the risk of lactic acidosis. The avoidance of hypoglycemia and excessive hyperglycemia intraoperatively is best achieved with frequent monitoring of blood glucose and treating abnormalities according to patients' preoperative regimen and current condition. Maintaining blood glucose levels below 110 mg/dL reduces morbidity and mortality in critically ill patients. Measure blood glucose immediately following surgery because progression of the stress response postoperatively, in addition to possible nausea and vomiting, can complicate the patient's management. Precautions should be taken to prevent damage to peripheral nerves while diabetics are on the operating table because their nerves and limbs are already vulnerable to pressure and stretch injuries secondary to neurologic and vascular disease. With thorough and careful management, metabolic control in the perioperative period is a goal that is attainable for most patients. FAU - Tamai, Doris AU - Tamai D AD - Department of Anesthesiology, Yale University, New Haven, CT 06520-8051, USA. FAU - Awad, Aymen Alian AU - Awad AA FAU - Chaudhry, Humayun J AU - Chaudhry HJ FAU - Shelley, Kirk H AU - Shelley KH LA - eng PT - Journal Article PT - Review PL - United States TA - Conn Med JT - Connecticut medicine JID - 0372745 SB - IM MH - Diabetes Complications/physiopathology/*surgery MH - Diagnostic Tests, Routine MH - Humans MH - Patient Care Planning MH - Postoperative Care/*methods MH - Preoperative Care/*methods RF - 67 EDAT- 2006/12/28 09:00 MHDA- 2007/02/09 09:00 CRDT- 2006/12/28 09:00 PHST- 2006/12/28 09:00 [pubmed] PHST- 2007/02/09 09:00 [medline] PHST- 2006/12/28 09:00 [entrez] PST - ppublish SO - Conn Med. 2006 Nov-Dec;70(10):621-30. PMID- 31294835 OWN - NLM STAT- MEDLINE DCOM- 20200206 LR - 20200206 IS - 1537-2197 (Electronic) IS - 0002-9122 (Linking) VI - 106 IP - 7 DP - 2019 Jul TI - Freezing resistance, safety margins, and survival vary among big sagebrush populations across the western United States. PG - 922-934 LID - 10.1002/ajb2.1320 [doi] AB - PREMISE: Physiological responses to temperature extremes are considered strong drivers of species' demographic responses to climate variability. Plants are typically classified as either avoiders or tolerators in their freezing-resistance mechanism, but a gradient of physiological-threshold freezing responses may exist among individuals of a species. Moreover, adaptive significance of physiological freezing responses is poorly characterized, particularly under warming conditions that relax selection on cold hardiness. METHODS: Freezing responses were measured in winter and again for new foliage in spring for 14 populations of Artemisia tridentata collected throughout its range and planted in a warm common garden. The relationships of the freezing responses to survival were evaluated in the warm garden and in two colder gardens. RESULTS: Winter and spring freezing resistance were not correlated and appeared to be under differing selection regimes, as evident in correlations with different population climate of origin variables. All populations resisted considerably lower temperatures in winter than in spring, with populations from more continental climates showing narrower freezing safety margins (difference in temperatures at which ice-nucleation occurs and 50% reduction in chlorophyll fluorescence occurs) in spring. Populations with greater winter freezing resistance had lower survivorship in the warmest garden, while populations with greater spring freezing resistance had lower survivorship in a colder garden. CONCLUSIONS: These survivorship patterns relative to physiological thresholds suggest excess freezing resistance may incur a survival cost that likely relates to a trade-off between carbon gain and freezing resistance during critical periods of moisture availability. This cost has implications for seed moved from cooler to warmer environments and for plants growing in warming environments. CI - © Published 2019. This article is a U.S. Government work and is in the public domain in the USA. FAU - Lazarus, Brynne E AU - Lazarus BE AUID- ORCID: 0000-0002-6352-486X AD - U. S. Geological Survey, Forest and Rangeland Ecosystem Science Center, 970 S. Lusk Street, Boise, ID, 83706, USA. FAU - Germino, Matthew J AU - Germino MJ AUID- ORCID: 0000-0001-6326-7579 AD - U. S. Geological Survey, Forest and Rangeland Ecosystem Science Center, 970 S. Lusk Street, Boise, ID, 83706, USA. FAU - Richardson, Bryce A AU - Richardson BA AUID- ORCID: 0000-0001-9521-4367 AD - USDA Forest Service, Rocky Mountain Research Station, 1221 S. Main St., Moscow, ID, 83843, USA. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190711 PL - United States TA - Am J Bot JT - American journal of botany JID - 0370467 RN - 059QF0KO0R (Water) SB - IM MH - Artemisia/*physiology MH - *Cold Climate MH - *Freezing MH - Northwestern United States MH - Seasons MH - Southwestern United States MH - Water/physiology OTO - NOTNLM OT - Artemisia tridentata OT - LT 50 OT - Asteraceae OT - cold hardiness OT - freezing avoidance OT - freezing resistance OT - freezing safety margin OT - freezing tolerance OT - ice nucleation temperature OT - relaxed selection EDAT- 2019/07/12 06:00 MHDA- 2020/02/07 06:00 CRDT- 2019/07/12 06:00 PHST- 2018/11/02 00:00 [received] PHST- 2019/05/01 00:00 [accepted] PHST- 2019/07/12 06:00 [pubmed] PHST- 2020/02/07 06:00 [medline] PHST- 2019/07/12 06:00 [entrez] AID - 10.1002/ajb2.1320 [doi] PST - ppublish SO - Am J Bot. 2019 Jul;106(7):922-934. doi: 10.1002/ajb2.1320. Epub 2019 Jul 11. PMID- 38153099 OWN - NLM STAT- MEDLINE DCOM- 20240823 LR - 20241230 IS - 1545-0813 (Electronic) IS - 1059-924X (Linking) VI - 29 IP - 3 DP - 2024 Jul TI - Agricultural Worker Perspectives on Climate Hazards and Risk Reduction Strategies. PG - 333-343 LID - 10.1080/1059924X.2023.2299378 [doi] AB - OBJECTIVE: The purpose of this study was to understand the experiences of agricultural workers during periods of heat and wildfire smoke exposure and to support the development and implementation of protective workplace interventions. METHODS: Using community-engaged research and the Center for Disease Control (CDC) framework for policy evaluation, a qualitative descriptive study was conducted with current and former agricultural workers in Central Washington (WA). Twelve participants answered semi-structured questions via interviews or by attending a focus group. Interviews and focus groups were conducted in Spanish, recorded, transcribed, and translated into English; one interview was conducted in English. RESULTS: Using Braun and Clarke's Reflexive Thematic Analysis, five themes were identified among workers from various worksites: 1) Extreme weather and working conditions are becoming increasingly hazardous to worker health, 2) Employers and supervisors lack training and education on current labor laws, and health and safety rules, 3) Employers and supervisors use intimidation and retaliation to ensure productivity and to evoke feelings of replaceability among workers, 4) Workers do not trust regulatory agencies to enforce rules or hold employers accountable, 5) Solutions to climate-driven problems in the agricultural industry need to value worker health and safety, not just productivity. Participants reported experiencing adverse health symptoms related to heat and smoke exposure at work. Workers proposed solutions including improving education, training, and communication, and increased enforcement of existing and forthcoming occupational health and safety rules. CONCLUSION: The agricultural workforce is essential for ensuring a robust food supply and is facing extreme weather events due to climate change. Western states impacted by wildfires and heat are working to develop and implement occupational health and safety rules. Developing effective policies and interventions inclusive of worker perspectives is critical to adapt to a changing climate, retain a stable workforce and promote optimal health. FAU - Parker, Molly AU - Parker M AUID- ORCID: 0000-0002-8762-0063 AD - College of Nursing, Washington State University, Spokane, USA. FAU - Ybarra-Vega, Mary Jo AU - Ybarra-Vega MJ AD - Outreach & Behavioral Health, Moses Lake Community Health Center, Moses Lake, WA, USA. FAU - Postma, Julie AU - Postma J AUID- ORCID: 0000-0001-9743-5526 AD - College of Nursing, Washington State University, Spokane, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231228 PL - England TA - J Agromedicine JT - Journal of agromedicine JID - 9421530 SB - IM MH - *Farmers MH - Humans MH - Hot Temperature MH - *Climate Change MH - *Occupational Health/legislation & jurisprudence MH - Wildfires MH - Environmental Justice MH - Washington MH - Food Supply OTO - NOTNLM OT - Agricultural workers OT - environmental justice OT - extreme heat OT - qualitative research OT - wildfire smoke EDAT- 2023/12/28 12:42 MHDA- 2024/05/25 20:47 CRDT- 2023/12/28 07:57 PHST- 2024/05/25 20:47 [medline] PHST- 2023/12/28 12:42 [pubmed] PHST- 2023/12/28 07:57 [entrez] AID - 10.1080/1059924X.2023.2299378 [doi] PST - ppublish SO - J Agromedicine. 2024 Jul;29(3):333-343. doi: 10.1080/1059924X.2023.2299378. Epub 2023 Dec 28. PMID- 37291795 OWN - NLM STAT- MEDLINE DCOM- 20230921 LR - 20230921 IS - 1365-2702 (Electronic) IS - 0962-1067 (Linking) VI - 32 IP - 19-20 DP - 2023 Oct TI - Healthcare workers' experiences of patient safety in the intensive care unit during the COVID-19 pandemic: A multicentre qualitative study. PG - 7372-7381 LID - 10.1111/jocn.16793 [doi] AB - AIM: To describe healthcare workers' experiences of preconditions and patient safety risks in intensive care units during the COVID-19 pandemic. BACKGROUND: Healthcare workers' ability to adapt to changing conditions is crucial to promote patient safety. During the COVID-19 pandemic, healthcare workers' capacity to maintain safe care was challenged and a more in-depth understanding on frontline experiences of patient safety is needed. DESIGN: A qualitative descriptive design. METHODS: Individual interviews were conducted with 29 healthcare workers (nurses, physicians, nurse assistants and physiotherapists) from three Swedish hospitals directly involved in intensive care of COVID-19 patients. Data were analysed with inductive content analysis. Reporting followed the COREQ checklist. RESULTS: Three categories were identified. Hazardous changes in working conditions describes patient safety challenges associated with the extreme workload with high stress level. Imperative adaptations induced by changed preconditions for patient safety which include descriptions of safety risks following adaptations related to temporary intensive care facilities, handling shortage of medical equipment and deviations from routines. Safety risks triggered by reorganisation of care describe how the diluted skill-mix and team disruptions exposed patients to safety risks, and that safety performance mostly relied on individual healthcare worker's responsibility. CONCLUSIONS: The study suggests that healthcare workers experienced an increase in patient safety risks during the COVID-19 pandemic mainly because the extremely high workload, imperative adaptations, and reorganisation of care regarding skill-mix and teamwork. Patient safety performance relied on the individuals' adaptability and responsibility rather than on system-based safety. RELEVANCE TO CLINICAL PRACTICE: This study provides insights on how healthcare workers' experiences can be used as a source of information for recognition of patient safety risks. To improve detection of safety risks during future crises, guidelines on how to approach safety from a system perspective must include healthcare workers' perceptions on safety risks. PATIENT AND PUBLIC CONTRIBUTION: None in the conceptualisation or design of the study. CI - © 2023 The Authors. Journal of Clinical Nursing published by John Wiley & Sons Ltd. FAU - Berggren, Karin AU - Berggren K AD - Department of Anesthesia and Intensive care, Södersjukhuset, Sweden. AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. FAU - Ekstedt, Mirjam AU - Ekstedt M AUID- ORCID: 0000-0002-4108-391X AD - Department of Health and Caring Sciences, Linnaeus University, Kalmar/Växjö, Sweden. AD - Department of Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden. FAU - Joelsson-Alm, Eva AU - Joelsson-Alm E AUID- ORCID: 0000-0002-9041-2468 AD - Department of Anesthesia and Intensive care, Södersjukhuset, Sweden. AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. FAU - Swedberg, Lena AU - Swedberg L AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. AD - Department of Patient Safety and Quality, Södertälje sjukhus, Södertälje, Sweden. FAU - Sackey, Peter AU - Sackey P AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - Schandl, Anna AU - Schandl A AUID- ORCID: 0000-0002-3603-1912 AD - Department of Anesthesia and Intensive care, Södersjukhuset, Sweden. AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. AD - Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. LA - eng GR - Löf- Regionernas ömsesidiga försäkringsbolag/ PT - Journal Article PT - Multicenter Study DEP - 20230608 PL - England TA - J Clin Nurs JT - Journal of clinical nursing JID - 9207302 MH - Humans MH - *COVID-19/epidemiology MH - Patient Safety MH - Pandemics MH - Health Personnel MH - Intensive Care Units MH - Qualitative Research OTO - NOTNLM OT - COVID-19 OT - intensive care OT - patient safety OT - qualitative research EDAT- 2023/06/09 06:42 MHDA- 2023/09/21 06:42 CRDT- 2023/06/09 01:12 PHST- 2023/05/17 00:00 [revised] PHST- 2022/08/19 00:00 [received] PHST- 2023/05/22 00:00 [accepted] PHST- 2023/09/21 06:42 [medline] PHST- 2023/06/09 06:42 [pubmed] PHST- 2023/06/09 01:12 [entrez] AID - 10.1111/jocn.16793 [doi] PST - ppublish SO - J Clin Nurs. 2023 Oct;32(19-20):7372-7381. doi: 10.1111/jocn.16793. Epub 2023 Jun 8. PMID- 39019134 OWN - NLM STAT- MEDLINE DCOM- 20240812 LR - 20240812 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 284 DP - 2024 Oct 1 TI - The neurological effects of acute physical exhaustion on inhibitory function. PG - 114641 LID - S0031-9384(24)00186-0 [pii] LID - 10.1016/j.physbeh.2024.114641 [doi] AB - OBJECTIVE: We aimed to investigate the neural mechanisms underlying the inhibitory function performance of maritime Search and Rescue (SAR) personnel in states of physical exhaustion. BACKGROUND: SAR missions pose serious challenges to the cognitive function of SAR personnel, especially in extreme environments and physical exhaustion. It is important to understand SAR personnel's cognitive performance and neural activity under exhaustion to improve the efficiency of task execution and ensure work safety. METHOD: Twenty-six maritime SAR personnel were recruited to simulate boat operations until they reached a self-imposed state of exhaustion. The exhaustion state was monitored by maximum heart rate and subjective fatigue scale. Two event-related potentials, N200 and P300, were measured during a Go-Nogo task before and after a session of acute exhaustive tasks. RESULTS: After exhaustion, a marked reduction in accuracy, a notable increase in N200 amplitude, and a substantial decline in P300 amplitude under the Nogo condition were observed compared to the baseline phase. Pre- and post-exhaustion comparisons using standardized low-resolution brain electromagnetic tomography revealed reduced activations in the right middle temporal gyrus's N200 component after exhaustion in SAR personnel during the Nogo condition. CONCLUSION: The results suggest that acute physical exhaustion significantly impacts the inhibition ability of SAR personnel, prolonging the conflict monitoring phase and weakening the response inhibition phase. These findings provide valuable insights into how physical exhaustion affects cognitive functions critical to the safety and effectiveness of SAR operations, and can inform strategies to improve training and equipment to enhance performance under extreme conditions. CI - Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Zhao, Shanguang AU - Zhao S AD - Department of Physical Education, Shanghai Maritime University, Shanghai, China. FAU - Ait-Belaid, Khaoula AU - Ait-Belaid K AD - Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, UK. FAU - Shen, Yanqing AU - Shen Y AD - School of Physical Education and Sport, Henan University, Kaifeng, China. Electronic address: 10250102@vip.henu.edu.cn. FAU - Zhou, Ke AU - Zhou K AD - School of Physical Education and Sport, Henan University, Kaifeng, China. LA - eng PT - Journal Article DEP - 20240715 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 SB - IM MH - Humans MH - Male MH - Adult MH - *Electroencephalography MH - *Inhibition, Psychological MH - Young Adult MH - *Fatigue/physiopathology MH - *Evoked Potentials/physiology MH - Heart Rate/physiology MH - Brain/physiology MH - Female MH - Psychomotor Performance/physiology OTO - NOTNLM OT - Event-related potentials OT - Inhibition function OT - Physical exhaustion OT - Search and rescue personnel OT - Standardized low-resolution brain electromagnetic tomography COIS- Declaration of competing interest All authors declare that they have no competing interests. EDAT- 2024/07/18 00:42 MHDA- 2024/08/12 06:43 CRDT- 2024/07/17 19:26 PHST- 2024/04/30 00:00 [received] PHST- 2024/07/11 00:00 [revised] PHST- 2024/07/13 00:00 [accepted] PHST- 2024/08/12 06:43 [medline] PHST- 2024/07/18 00:42 [pubmed] PHST- 2024/07/17 19:26 [entrez] AID - S0031-9384(24)00186-0 [pii] AID - 10.1016/j.physbeh.2024.114641 [doi] PST - ppublish SO - Physiol Behav. 2024 Oct 1;284:114641. doi: 10.1016/j.physbeh.2024.114641. Epub 2024 Jul 15. PMID- 36360121 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 11 IP - 21 DP - 2022 Nov 4 TI - Lettuce Contamination and Survival of Salmonella Typhimurium and Listeria monocytogenes in Hydroponic Nutrient Film Technique Systems. LID - 10.3390/foods11213508 [doi] LID - 3508 AB - Hydroponic vegetable production is increasing globally, but there is a lack of science-based recommendations to ensure their food safety. Specifically, there is limited evidence for establishing water management strategies. The purpose of this study was to determine the survival of Salmonella Typhimurium and Listeria monocytogenes in commercial nutrient flow technology (NFT) systems during the lifecycle of lettuce exposed to sporadic or extreme contamination. NFT systems were inoculated with Salmonella Typhimurium or Listeria monocytogenes, and nutrient solution, rockwool, roots, and lettuce leaves were collected over the lettuce production cycle for pathogen enumeration and detection. Both human pathogens persisted in the lettuce NFT growing system throughout the growth cycle of lettuce. Salmonella Typhimurium and L. monocytogenes accumulated in rockwool medium and on lettuce roots and were transferred to the leaves at quantifiable levels from the contaminated nutrient solution. In the nutrient solution, Salmonella concentration under sporadic and extreme conditions declined significantly 24 h after inoculation and again 7 days post-inoculation (p < 0.0001). Under extreme conditions, the concentration did not change significantly after 7 days, while under sporadic conditions, the concentration declined again 14 days post-inoculation in the nutrient solution collected from the reservoirs. L. monocytogenes populations in the nutrient solution fluctuated significantly over the 28-day growth cycle (p < 0.0001). Under extreme conditions, L. monocytogenes concentrations in the nutrient solution declined, while under sporadic conditions, the populations increased. The findings of this study, for the first time, describe human pathogen survival in commerical NFT systems and highlight the urgent need for novel approaches to mitigating the risks from nutrient solution contaminaiton in hydroponics. FAU - Ilic, Sanja AU - Ilic S AUID- ORCID: 0000-0003-3450-2693 AD - Human Nutrition, Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA. FAU - Moodispaw, Margaret R AU - Moodispaw MR AUID- ORCID: 0000-0003-3371-2015 AD - Human Nutrition, Department of Human Sciences, College of Education and Human Ecology, The Ohio State University, Columbus, OH 43210, USA. FAU - Madden, Lawrence V AU - Madden LV AD - Department of Plant Pathology, College of Food, Agricultural and Environmental Sciences-Wooster, The Ohio State University, Wooster, OH 44691, USA. FAU - Lewis Ivey, Melanie L AU - Lewis Ivey ML AUID- ORCID: 0000-0001-7520-9026 AD - Department of Plant Pathology, College of Food, Agricultural and Environmental Sciences-Wooster, The Ohio State University, Wooster, OH 44691, USA. LA - eng GR - SBCG-2017 AW-103406/Ohio Department of Agriculture/ PT - Journal Article DEP - 20221104 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC9657165 OTO - NOTNLM OT - Listeria monocytogenes OT - Salmonella OT - food safety OT - hydroponics OT - nutrient OT - nutrient film technique OT - prevention OT - water quality COIS- The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2022/11/12 06:00 MHDA- 2022/11/12 06:01 PMCR- 2022/11/04 CRDT- 2022/11/11 01:14 PHST- 2022/10/12 00:00 [received] PHST- 2022/10/31 00:00 [revised] PHST- 2022/11/02 00:00 [accepted] PHST- 2022/11/11 01:14 [entrez] PHST- 2022/11/12 06:00 [pubmed] PHST- 2022/11/12 06:01 [medline] PHST- 2022/11/04 00:00 [pmc-release] AID - foods11213508 [pii] AID - foods-11-03508 [pii] AID - 10.3390/foods11213508 [doi] PST - epublish SO - Foods. 2022 Nov 4;11(21):3508. doi: 10.3390/foods11213508. PMID- 23568375 OWN - NLM STAT- MEDLINE DCOM- 20140116 LR - 20211021 IS - 1179-2035 (Electronic) IS - 0112-1642 (Linking) VI - 43 IP - 6 DP - 2013 Jun TI - Crawling to the finish line: why do endurance runners collapse? Implications for understanding of mechanisms underlying pacing and fatigue. PG - 413-24 LID - 10.1007/s40279-013-0044-y [doi] AB - Effective regulation of pace enables the majority of runners to complete competitive endurance events without mishap. However, some runners do experience exercise-induced collapse associated with postural hypotension, which in rare cases results from life-threatening conditions such as cardiac disorders, cerebral events, heat stroke and hyponatraemia. Despite the experience of either catastrophic system failure or extreme peripheral muscle fatigue, some runners persist in attempting to reach the finish line, and this often results in a sequence of dynamic changes in posture and gait that we have termed the 'Foster collapse positions'. The initial stage involves an unstable gait and the runner assumes the 'Early Foster' collapse position with hips slightly flexed and their head lowered. This unstable gait further degrades into a shuffle referred to as the 'Half Foster' collapse position characterized by hip flexion of approximately 90° with the trunk and head parallel to the ground. At this point, the muscles of postural support and the co-ordination of propulsion begin to be compromised. If the condition worsens, the runner will fall to the ground and assume the 'Full Foster' collapse position, which involves crawling forwards on knees and elbows towards the finish line, with their trunk angled such that the head is at a lower angle than the hips. Upon reaching the finish line, or sometimes before that, the runner may collapse and remain prone until recovering either with or without assistance or medical treatment. The Foster collapse positions are indicative of a final, likely primordial, protective mechanism designed to attenuate postural hypotension, cardiac 'pump' insufficiency or cerebral blood flow deficiency. Continuing to attempt to reach the finish line in this impaired state is also perhaps indicative of a high psychological drive or a variety of neurological and psychological pathologies such as diminished sensitivity to interoceptive feedback, unrealistic situational appraisal or extreme motivational drives. A better understanding of the physiological, neurological and psychological antecedents of the Foster collapse sequence remains an important issue with practical implications for runner safety and theoretical understanding of collapses during exercise. FAU - St Clair Gibson, Alan AU - St Clair Gibson A AD - Department of Sport and Exercise Sciences, Sport, Exercise and Wellbeing Research Centre, Faculty of Health and Life Sciences, Northumbria University, Northumberland Road, Newcastle upon Tyne, NE1 8ST, UK. a.stclairgibson@northumbria.ac.uk FAU - De Koning, Jos J AU - De Koning JJ FAU - Thompson, Kevin G AU - Thompson KG FAU - Roberts, William O AU - Roberts WO FAU - Micklewright, Dominic AU - Micklewright D FAU - Raglin, John AU - Raglin J FAU - Foster, Carl AU - Foster C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM MH - Athletes/*psychology MH - Exercise/*physiology/psychology MH - Fatigue/*physiopathology/psychology MH - Humans MH - Physical Endurance/*physiology MH - Posture MH - Running/*physiology/psychology EDAT- 2013/04/10 06:00 MHDA- 2014/01/17 06:00 CRDT- 2013/04/10 06:00 PHST- 2013/04/10 06:00 [entrez] PHST- 2013/04/10 06:00 [pubmed] PHST- 2014/01/17 06:00 [medline] AID - 10.1007/s40279-013-0044-y [doi] PST - ppublish SO - Sports Med. 2013 Jun;43(6):413-24. doi: 10.1007/s40279-013-0044-y. PMID- 22680067 OWN - NLM STAT- MEDLINE DCOM- 20130103 LR - 20131121 IS - 1936-086X (Electronic) IS - 1936-0851 (Linking) VI - 6 IP - 8 DP - 2012 Aug 28 TI - Liquid-infused nanostructured surfaces with extreme anti-ice and anti-frost performance. PG - 6569-77 LID - 10.1021/nn302310q [doi] AB - Ice-repellent coatings can have significant impact on global energy savings and improving safety in many infrastructures, transportation, and cooling systems. Recent efforts for developing ice-phobic surfaces have been mostly devoted to utilizing lotus-leaf-inspired superhydrophobic surfaces, yet these surfaces fail in high-humidity conditions due to water condensation and frost formation and even lead to increased ice adhesion due to a large surface area. We report a radically different type of ice-repellent material based on slippery, liquid-infused porous surfaces (SLIPS), where a stable, ultrasmooth, low-hysteresis lubricant overlayer is maintained by infusing a water-immiscible liquid into a nanostructured surface chemically functionalized to have a high affinity to the infiltrated liquid and lock it in place. We develop a direct fabrication method of SLIPS on industrially relevant metals, particularly aluminum, one of the most widely used lightweight structural materials. We demonstrate that SLIPS-coated Al surfaces not only suppress ice/frost accretion by effectively removing condensed moisture but also exhibit at least an order of magnitude lower ice adhesion than state-of-the-art materials. On the basis of a theoretical analysis followed by extensive icing/deicing experiments, we discuss special advantages of SLIPS as ice-repellent surfaces: highly reduced sliding droplet sizes resulting from the extremely low contact angle hysteresis. We show that our surfaces remain essentially frost-free in which any conventional materials accumulate ice. These results indicate that SLIPS is a promising candidate for developing robust anti-icing materials for broad applications, such as refrigeration, aviation, roofs, wires, outdoor signs, railings, and wind turbines. FAU - Kim, Philseok AU - Kim P AD - Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, USA. FAU - Wong, Tak-Sing AU - Wong TS FAU - Alvarenga, Jack AU - Alvarenga J FAU - Kreder, Michael J AU - Kreder MJ FAU - Adorno-Martinez, Wilmer E AU - Adorno-Martinez WE FAU - Aizenberg, Joanna AU - Aizenberg J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20120615 PL - United States TA - ACS Nano JT - ACS nano JID - 101313589 RN - 0 (Ice) RN - 0 (Macromolecular Substances) RN - 0 (Solutions) RN - CPD4NFA903 (Aluminum) SB - IM CIN - ACS Nano. 2012 Aug 28;6(8):6536-40. doi: 10.1021/nn303372q. PMID: 22876765 MH - Aluminum/*chemistry MH - Crystallization/*methods MH - Friction MH - Hydrophobic and Hydrophilic Interactions MH - Ice/*analysis MH - Macromolecular Substances/chemistry MH - Materials Testing MH - Molecular Conformation MH - Nanostructures/*chemistry/*ultrastructure MH - Particle Size MH - Porosity MH - Solutions/*chemistry MH - Surface Properties EDAT- 2012/06/12 06:00 MHDA- 2013/01/04 06:00 CRDT- 2012/06/12 06:00 PHST- 2012/06/12 06:00 [entrez] PHST- 2012/06/12 06:00 [pubmed] PHST- 2013/01/04 06:00 [medline] AID - 10.1021/nn302310q [doi] PST - ppublish SO - ACS Nano. 2012 Aug 28;6(8):6569-77. doi: 10.1021/nn302310q. Epub 2012 Jun 15. PMID- 25086160 OWN - NLM STAT- MEDLINE DCOM- 20140929 LR - 20220408 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 134 IP - 2 DP - 2014 Aug TI - Safety of vaccines used for routine immunization of U.S. children: a systematic review. PG - 325-37 LID - 10.1542/peds.2014-1079 [doi] AB - BACKGROUND: Concerns about vaccine safety have led some parents to decline recommended vaccination of their children, leading to the resurgence of diseases. Reassurance of vaccine safety remains critical for population health. This study systematically reviewed the literature on the safety of routine vaccines recommended for children in the United States. METHODS: Data sources included PubMed, Advisory Committee on Immunization Practices statements, package inserts, existing reviews, manufacturer information packets, and the 2011 Institute of Medicine consensus report on vaccine safety. We augmented the Institute of Medicine report with more recent studies and increased the scope to include more vaccines. Only studies that used active surveillance and had a control mechanism were included. Formulations not used in the United States were excluded. Adverse events and patient and vaccine characteristics were abstracted. Adverse event collection and reporting was evaluated by using the McHarm scale. We were unable to pool results. Strength of evidence was rated as high, moderate, low, or insufficient. RESULTS: Of 20 478 titles identified, 67 were included. Strength of evidence was high for measles/mumps/rubella (MMR) vaccine and febrile seizures; the varicella vaccine was associated with complications in immunodeficient individuals. There is strong evidence that MMR vaccine is not associated with autism. There is moderate evidence that rotavirus vaccines are associated with intussusception. Limitations of the study include that the majority of studies did not investigate or identify risk factors for AEs; and the severity of AEs was inconsistently reported. CONCLUSIONS: We found evidence that some vaccines are associated with serious AEs; however, these events are extremely rare and must be weighed against the protective benefits that vaccines provide. CI - Copyright © 2014 by the American Academy of Pediatrics. FAU - Maglione, Margaret A AU - Maglione MA AD - RAND Corporation, Santa Monica, California; maglione@rand.org. FAU - Das, Lopamudra AU - Das L AD - RAND Corporation, Santa Monica, California; FAU - Raaen, Laura AU - Raaen L AD - RAND Corporation, Santa Monica, California; FAU - Smith, Alexandria AU - Smith A AD - RAND Corporation, Santa Monica, California; FAU - Chari, Ramya AU - Chari R AD - RAND Corporation, Santa Monica, California; FAU - Newberry, Sydne AU - Newberry S AD - RAND Corporation, Santa Monica, California; FAU - Shanman, Roberta AU - Shanman R AD - RAND Corporation, Santa Monica, California; FAU - Perry, Tanja AU - Perry T AD - RAND Corporation, Santa Monica, California; FAU - Goetz, Matthew Bidwell AU - Goetz MB AD - VA Greater Los Angeles Healthcare System and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and. FAU - Gidengil, Courtney AU - Gidengil C AD - RAND Corporation, Santa Monica, California;Boston Children's Hospital, Boston, Massachusetts. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20140701 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 RN - 0 (Chickenpox Vaccine) RN - 0 (Measles-Mumps-Rubella Vaccine) RN - 0 (Rotavirus Vaccines) RN - 0 (Vaccines) RN - 0 (Viral Hepatitis Vaccines) SB - IM CIN - Pediatrics. 2014 Aug;134(2):377-9. doi: 10.1542/peds.2014-1494. PMID: 25086161 MH - Chickenpox Vaccine MH - Child MH - Humans MH - Immunization MH - Measles-Mumps-Rubella Vaccine MH - Patient Safety MH - Population Surveillance MH - Rotavirus Vaccines/adverse effects MH - United States MH - Vaccines/*adverse effects MH - Viral Hepatitis Vaccines/adverse effects OTO - NOTNLM OT - evidence-based medicine OT - infectious disease OT - vaccine/immunization EDAT- 2014/08/03 06:00 MHDA- 2014/09/30 06:00 CRDT- 2014/08/03 06:00 PHST- 2014/08/03 06:00 [entrez] PHST- 2014/08/03 06:00 [pubmed] PHST- 2014/09/30 06:00 [medline] AID - peds.2014-1079 [pii] AID - 10.1542/peds.2014-1079 [doi] PST - ppublish SO - Pediatrics. 2014 Aug;134(2):325-37. doi: 10.1542/peds.2014-1079. Epub 2014 Jul 1. PMID- 37740801 OWN - NLM STAT- MEDLINE DCOM- 20231030 LR - 20231030 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 30 IP - 49 DP - 2023 Oct TI - Stability and probabilistic assessment of a large asymmetric bedding slope with a weak interlayer. PG - 107811-107826 LID - 10.1007/s11356-023-29655-7 [doi] AB - The mining of open-pit mines has a significant influence on the surrounding ecological environment and safety. Once the slope of an open pit is unstable, it will bring extremely severe disasters to the surrounding environment. The south slope of the Fushun West open-pit mine is a large bedding slope with weak interlayer and asymmetrical features between the eastern and western regions. The different deformation mechanisms are worth further discussion, and the deformation mechanism of the eastern region needs to be systematically investigated. In this study, a comprehensive method combining a numerical model, the limit equilibrium method, and a probabilistic approach is used. The different deformation mechanisms of the slope are explored. Thereafter, the sensitivity of the geometric and mechanical parameters of the slope is determined. Finally, the probability of failure (PF) and slope stability are evaluated. The results illustrate that the difference in geological characteristics and constraint conditions is the fundamental reason for the difference in deformation features of the slope. The sensitivity analysis results show that the friction angle of the weak layer exhibits the most sensitivity and that the unit weight is irrelevant to the slope stability. Taking the friction angle of the weak layer as a variable, when the thickness of the basalt layer is less than 140 m and the height of the slope is more than 360 m, the PF of the slope reaches a high value. When the inclination of the weak layer exceeds 30°, the PF of the slope increases to a high value. When the R(u) coefficient exceeds 0.2, the slope presents a high PF. The results illustrate that decision-makers should pay attention to the strength degradation, transitional mining of the basalt layer, and establish a good drainage system. The comprehensive method can also provide an effective way to assess the stability and PF of similar large-scale bedding slopes under complex geological conditions. CI - © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zhang, Fei AU - Zhang F AD - Key Laboratory of Roads and Railway Engineering Safety Control, Shijiazhuang Tiedao University, Ministry of Education, Shijiazhuang, 050043, China. zhangfei@stdu.edu.cn. AD - State Key Laboratory of Mechanical Behavior and System Safety of Traffic Engineering Structures, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. zhangfei@stdu.edu.cn. AD - School of Civil Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. zhangfei@stdu.edu.cn. FAU - Yang, Tianhong AU - Yang T AD - School of Resources and Civil Engineering, Northeastern University, Shenyang, 110819, Liaoning, China. LA - eng GR - B2021003021/High-level Talent Foundation of Hebei Province/ PT - Journal Article DEP - 20230923 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (basalt) SB - IM MH - *Mining MH - *Disasters MH - Geology MH - Probability OTO - NOTNLM OT - Asymmetric complex condition OT - Failure probability of slope OT - Large bedding slope OT - Stability evaluation EDAT- 2023/09/23 20:41 MHDA- 2023/10/30 06:47 CRDT- 2023/09/23 11:06 PHST- 2023/06/20 00:00 [received] PHST- 2023/08/29 00:00 [accepted] PHST- 2023/10/30 06:47 [medline] PHST- 2023/09/23 20:41 [pubmed] PHST- 2023/09/23 11:06 [entrez] AID - 10.1007/s11356-023-29655-7 [pii] AID - 10.1007/s11356-023-29655-7 [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2023 Oct;30(49):107811-107826. doi: 10.1007/s11356-023-29655-7. Epub 2023 Sep 23. PMID- 22392828 OWN - NLM STAT- MEDLINE DCOM- 20121022 LR - 20120306 IS - 1875-9114 (Electronic) IS - 0277-0008 (Linking) VI - 32 IP - 1 DP - 2012 Jan TI - Medical management of adult transsexual persons. PG - 54-66 LID - 10.1002/PHAR.1006 [doi] AB - Gender identity disorder (GID), or transsexualism, is an increasingly recognized medical condition with an expanding body of medical literature to support the use of established therapeutic guidelines. Transsexualism can be effectively managed through exogenous cross-sex hormone administration used to induce development of desired sex characteristics, as well as use of other agents, such as aldosterone antagonists, aimed at decreasing physical characteristics of the undesired sex. Many complications can arise with the use of the available therapies, and these must be considered before determining the appropriate course of action. This review describes methods, including both pharmacotherapy and surgical interventions, for effective medical management of both male and female adults with GID. In addition, specific goals of therapy as well as safety aspects with long-term use of pharmacotherapeutic agents are discussed. This review also discusses some special considerations for treating patients with significant, yet common, comorbid diseases such as human immunodeficiency virus infection, acquired immunodeficiency syndrome, and viral hepatitis, as these conditions may complicate the clinical course and preclude some patients from using certain therapies. Pharmacist involvement in the management of transsexualism can be extremely beneficial to patients and other health care providers. Pharmacists can help determine the appropriate therapy, optimize dosages, monitor for adverse effects, and educate patients on what to expect during their therapy. Pharmacists should become knowledgeable about guidelines and current literature on transsexualism, understand the monitoring parameters for safe and effective therapy, and establish themselves as partners in the collaborative management of this disorder. CI - © 2012, Pharmacotherapy Publications, Inc. FAU - Knezevich, Emily L AU - Knezevich EL AD - Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE 68178, USA. eknezevich@creighton.edu FAU - Viereck, Laura K AU - Viereck LK FAU - Drincic, Andjela T AU - Drincic AT LA - eng PT - Journal Article PT - Review PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 0 (Gonadal Steroid Hormones) SB - IM MH - Adult MH - Disease Management MH - Female MH - *Gender Identity MH - Gonadal Steroid Hormones/therapeutic use MH - Hormone Replacement Therapy/methods MH - Humans MH - Male MH - Pharmacists/trends MH - Transsexualism/*diagnosis/psychology/*therapy EDAT- 2012/03/07 06:00 MHDA- 2012/10/23 06:00 CRDT- 2012/03/07 06:00 PHST- 2012/03/07 06:00 [entrez] PHST- 2012/03/07 06:00 [pubmed] PHST- 2012/10/23 06:00 [medline] AID - 10.1002/PHAR.1006 [doi] PST - ppublish SO - Pharmacotherapy. 2012 Jan;32(1):54-66. doi: 10.1002/PHAR.1006. PMID- 34738407 OWN - NLM STAT- MEDLINE DCOM- 20211108 LR - 20220531 IS - 1001-5302 (Print) IS - 1001-5302 (Linking) VI - 46 IP - 19 DP - 2021 Oct TI - [Overview of systematic reviews on Kuntai Capsules in treatment of perimenopausal syndrome]. PG - 5103-5109 LID - 10.19540/j.cnki.cjcmm.20210201.501 [doi] AB - To evaluate the efficacy and safety of Kuntai Capsules in the treatment of perimenopausal syndrome. Systematic reviews on Kuntai Capsules in the treatment of perimenopausal syndrome were retrieved from Chinese and English databases from database establishment to August 31, 2020. AMSTER-2 scale, GRADE scale and ROBIS tools were used respectively to evaluate the methodological quality, evidence quality level and bias risk of the finally included systematic reviews. A total of 6 systematic reviews with 28 outcome indicators were included. The results of AMSTER-2 methodological quality assessment showed that one of the six systematic reviews was of low quality, and the other five were of extremely low quality. GRADE scale showed that 28 clinical outcome indicators were evaluated, three of which were intermediate-level ones, and the rest were low-level or very low-level ones. Two evidences of the three intermediate evidences were total efficiency, and the other intermediate evidence was Kupperman score. ROBIS bias risk assessment showed all the included studies were of high risk. The results showed that, Kuntai Capsules were effective in the treatment of perimenopausal symptoms, such as hot flashes and sweating. The improvement of E_2 level was not as good as that in the menopause hormone therapy group, but the incidence of adverse reactions was lower than that in the menopause hormone therapy group. However, the quality of evidence needs to be improved due to the low quality of methodology and high risk of bias. It is suggested that systematic review and reasonable design should be carried out in the future, and attention should be paid to the registration of research schemes. In addition, the research reports shall be prepared according to PRISMA statement. FAU - Men, Xiao-Liang AU - Men XL AD - Beijing Daxing District Maternal and Children Health Care Hospital Beijing 102600, China. FAU - Zhao, Li-Ping AU - Zhao LP AD - Beijing Daxing District Maternal and Children Health Care Hospital Beijing 102600, China. FAU - Yang, Jie AU - Yang J AD - Beijing Daxing District Maternal and Children Health Care Hospital Beijing 102600, China. FAU - Li, Bo AU - Li B AD - Beijing Hospital of Traditional Chinese Medicine, Capital Medical University Beijing 100010, China. LA - chi PT - Journal Article PT - Review PL - China TA - Zhongguo Zhong Yao Za Zhi JT - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JID - 8913656 RN - 0 (Drugs, Chinese Herbal) RN - 0 (kuntai capsule) SB - IM MH - *Drugs, Chinese Herbal MH - Female MH - Hormone Replacement Therapy MH - Humans MH - *Perimenopause MH - Syndrome MH - Systematic Reviews as Topic OTO - NOTNLM OT - AMSTER-2 OT - GRADE OT - Kuntai Capsules OT - ROBIS OT - overview of systematic reviews OT - perimenopausal syndrome EDAT- 2021/11/06 06:00 MHDA- 2021/11/09 06:00 CRDT- 2021/11/05 07:09 PHST- 2021/11/05 07:09 [entrez] PHST- 2021/11/06 06:00 [pubmed] PHST- 2021/11/09 06:00 [medline] AID - 10.19540/j.cnki.cjcmm.20210201.501 [doi] PST - ppublish SO - Zhongguo Zhong Yao Za Zhi. 2021 Oct;46(19):5103-5109. doi: 10.19540/j.cnki.cjcmm.20210201.501. PMID- 24273472 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220310 IS - 1573-3882 (Print) IS - 1573-3890 (Electronic) IS - 1573-3882 (Linking) VI - 9 IP - 6 DP - 2013 TI - Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance. PG - 1134-1156 LID - 10.1007/s11306-013-0556-3 [doi] AB - Space flight is one of the most extreme conditions encountered by humans. Advances in Omics methodologies (genomics, transcriptomics, proteomics, and metabolomics) have revealed that unique differences exist between individuals. These differences can be amplified in extreme conditions, such as space flight. A better understanding of individual differences may allow us to develop personalized countermeasure packages that optimize the safety and performance of each astronaut. In this review, we explore the role of "Omics" in advancing our ability to: (1) more thoroughly describe the biological response of humans in space; (2) describe molecular attributes of individual astronauts that alter the risk profile prior to entering the space environment; (3) deploy Omics techniques in the development of personalized countermeasures; and (4) develop a comprehensive Omics-based assessment and countermeasure platform that will guide human space flight in the future. In this review, we advance the concept of personalized medicine in human space flight, with the goal of enhancing astronaut safety and performance. Because the field is vast, we explore selected examples where biochemical individuality might significantly impact countermeasure development. These include gene and small molecule variants associated with: (1) metabolism of therapeutic drugs used in space; (2) one carbon metabolism and DNA stability; (3) iron metabolism, oxidative stress and damage, and DNA stability; and (4) essential input (Mg and Zn) effects on DNA repair. From these examples, we advance the case that widespread Omics profiling should serve as the foundation for aerospace medicine and research, explore methodological considerations to advance the field, and suggest why personalized medicine may become the standard of care for humans in space. FAU - Schmidt, Michael A AU - Schmidt MA AD - Advanced Pattern Analysis & Countermeasures Group, MetaboLogics. LLC, Infectious Disease Research Complex, Colorado State University, 3185 Rampart Road, Fort Collins, CO 80521 USA. ISNI: 0000 0004 1936 8083. GRID: grid.47894.36 FAU - Goodwin, Thomas J AU - Goodwin TJ AD - NASA Johnson Space Center, Disease Modeling and Tissue Analogues Laboratory, Biomedical Research and Environmental Sciences Division, Houston, TX 77058 USA. ISNI: 0000 0004 0613 2864. GRID: grid.419085.1 LA - eng PT - Journal Article DEP - 20130627 PL - United States TA - Metabolomics JT - Metabolomics : Official journal of the Metabolomic Society JID - 101274889 PMC - PMC3825629 OTO - NOTNLM OT - Astronaut health OT - DNA repair OT - DNA stability OT - Essential inputs OT - Exploration OT - Genomics OT - Human OT - Human performance OT - Metabolomics OT - Micronutrient OT - Omics OT - Oxidative stress OT - Personalized medicine OT - Proteomics OT - Single nucleotide polymorphism OT - Space flight OT - Systems biology OT - Transcriptomics EDAT- 2013/11/26 06:00 MHDA- 2013/11/26 06:01 PMCR- 2013/06/27 CRDT- 2013/11/26 06:00 PHST- 2013/05/05 00:00 [received] PHST- 2013/06/03 00:00 [accepted] PHST- 2013/11/26 06:00 [pubmed] PHST- 2013/11/26 06:01 [medline] PHST- 2013/11/26 06:00 [entrez] PHST- 2013/06/27 00:00 [pmc-release] AID - 556 [pii] AID - 10.1007/s11306-013-0556-3 [doi] PST - ppublish SO - Metabolomics. 2013;9(6):1134-1156. doi: 10.1007/s11306-013-0556-3. Epub 2013 Jun 27. PMID- 25851216 OWN - NLM STAT- MEDLINE DCOM- 20160311 LR - 20181202 IS - 1179-1969 (Electronic) IS - 1170-229X (Linking) VI - 32 IP - 4 DP - 2015 Apr TI - Management of chronic spontaneous urticaria in the elderly. PG - 271-82 LID - 10.1007/s40266-015-0249-x [doi] AB - The guidelines for the management of urticaria in adults and children have been revised and updated recently. However, there are few data in the literature concerning several aspects of this disease in the elderly (e.g., epidemiology, etiopathogenesis, clinical aspects, association with co-morbidities, efficacy and safety profiles of treatments, and management strategies). This is an obvious deficiency in the data, as this disease causes a deterioration in quality of life, affecting the quality of sleep, everyday life habits and activities, and inducing severe disability. Chronic spontaneous urticaria (CSU) can also be associated with internal, infectious, autoimmune, or neoplastic diseases. It is therefore necessary to pay particular attention to these clinical issues through appropriate clinical examinations. At the same time, the specific features of medications used to treat CSU in the elderly should be carefully evaluated, as its pharmacological treatment raises a number of problems related both to the clinical condition of the patient and to concomitant diseases, as well as to the polypharmacotherapy, which is common in older subjects and may cause safety problems because of the drug interactions. Non-sedating new-generation antihistamines are the mainstay treatment of CSU for the elderly. The efficacy and safety of alternative treatment options have not been assessed in the geriatric population with CSU; corticosteroids and cyclosporine (ciclosporin) should be used by this population with extreme caution. Similarly, there are no data regarding the actual safety profile of the new-generation antihistamines at higher doses than those recommended in elderly patients. FAU - Ventura, Maria Teresa AU - Ventura MT AD - Department of Interdisciplinary Medicine (DIM), University of Bari, Medical School, Policlinico, Unit of Geriatric Immunoallergology, Policlinico, piazza G. Cesare, 70124, Bari, Italy, Mariateresa.ventura@uniba.it. FAU - Cassano, Nicoletta AU - Cassano N FAU - Romita, Paolo AU - Romita P FAU - Vestita, Michelangelo AU - Vestita M FAU - Foti, Caterina AU - Foti C FAU - Vena, Gino Antonio AU - Vena GA LA - eng PT - Journal Article PL - New Zealand TA - Drugs Aging JT - Drugs & aging JID - 9102074 RN - 0 (Histamine Antagonists) RN - 0 (Histamine H1 Antagonists, Non-Sedating) RN - 83HN0GTJ6D (Cyclosporine) SB - IM MH - Aged MH - Chronic Disease MH - Cyclosporine/therapeutic use MH - Histamine Antagonists/*therapeutic use MH - Histamine H1 Antagonists, Non-Sedating/therapeutic use MH - Humans MH - *Quality of Life MH - Urticaria/*therapy EDAT- 2015/04/09 06:00 MHDA- 2016/03/12 06:00 CRDT- 2015/04/09 06:00 PHST- 2015/04/09 06:00 [entrez] PHST- 2015/04/09 06:00 [pubmed] PHST- 2016/03/12 06:00 [medline] AID - 10.1007/s40266-015-0249-x [doi] PST - ppublish SO - Drugs Aging. 2015 Apr;32(4):271-82. doi: 10.1007/s40266-015-0249-x. PMID- 36113332 OWN - NLM STAT- MEDLINE DCOM- 20221014 LR - 20221014 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 177 DP - 2022 Nov TI - A reliability-based weather-responsive variable speed limit system to improve the safety of rural highways. PG - 106831 LID - S0001-4575(22)00266-4 [pii] LID - 10.1016/j.aap.2022.106831 [doi] AB - Weather-responsive Variable Speed Limit (WRVSL) systems treat speed limits as weather-dependent random variables, as opposed to the conventional static speed limits. This study (i) evaluates drivers' response to a fixed speed limit in different road-weather conditions, and (ii) proposes an effective approach to set WRVSLs, for rural divided highways located in extremely cold regions. Study data: road-weather, and speed data, collected from a rural highway (fixed speed limit = 110 km/h), are used to (i) estimate the 85(th) percentile speeds of population-level speed distributions, and (ii) develop WRVSLs based on the reliability theory. More specifically, the WRVSLs are set based on reliability: the probability of a speed being (i) likely complied by drivers, and (ii) adequate to avoid a rear-end collision. The study results reveal that merely 73 % of the drivers at the study site comply with the existing posted speed limit under normal road-weather conditions i.e., no precipitation and dry pavements. The reliability of the current speed limit is revealed to be approximately-one under normal road-weather conditions; thus, the current speed limit is perceived credible under such road-weather conditions. Yet, reliability of the current speed limit is substantially reduced in the presence of slight snow, and ice warning pavement conditions. A set of reliability-based WRVSLs ranging from 80 to 110 km/h is proposed. Jurisdictions experiencing extreme road-weather conditions may adapt the proposed methodology to effectively manage speed, particularly in rural highways under adverse road-weather conditions to enhance the probability of speed limits being safe and complied by drivers and as a result reduce crash propensity. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Yasanthi, Rillagoda G N AU - Yasanthi RGN AD - Department of Civil Engineering, University of Manitoba, 15 Gillson Street, Winnipeg, MB R3T 5V6, Canada. FAU - Mehran, Babak AU - Mehran B AD - Department of Civil Engineering, University of Manitoba, 15 Gillson Street, Winnipeg, MB R3T 5V6, Canada. Electronic address: babak.mehran@umanitoba.ca. FAU - Alhajyaseen, Wael K M AU - Alhajyaseen WKM AD - Qatar Transportation and Traffic Safety Center, College of Engineering, Qatar University, P.O.Box : 2713, Doha, Qata; Department of Civil and Architectural Engineering, College of Engineering, Qatar University, P.O.Box : 2713, Doha, Qatar. LA - eng PT - Journal Article DEP - 20220914 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 RN - 0 (Ice) SB - IM MH - Accidents, Traffic/prevention & control MH - *Automobile Driving MH - Humans MH - Ice MH - Reproducibility of Results MH - Safety MH - Weather OTO - NOTNLM OT - Adverse road-weather OT - Rear-end collision OT - Rural highway OT - Variable speed limit OT - Weather-responsive traffic management COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/09/17 06:00 MHDA- 2022/10/15 06:00 CRDT- 2022/09/16 18:25 PHST- 2022/05/12 00:00 [received] PHST- 2022/08/13 00:00 [revised] PHST- 2022/09/02 00:00 [accepted] PHST- 2022/09/17 06:00 [pubmed] PHST- 2022/10/15 06:00 [medline] PHST- 2022/09/16 18:25 [entrez] AID - S0001-4575(22)00266-4 [pii] AID - 10.1016/j.aap.2022.106831 [doi] PST - ppublish SO - Accid Anal Prev. 2022 Nov;177:106831. doi: 10.1016/j.aap.2022.106831. Epub 2022 Sep 14. PMID- 18177258 OWN - NLM STAT- MEDLINE DCOM- 20080228 LR - 20080107 IS - 1050-7256 (Print) IS - 1050-7256 (Linking) VI - 17 IP - 12 DP - 2007 Dec TI - The impaired hypothyroid patient: ethical considerations and obligations. PG - 1261-7 LID - 10.1089/thy.2007.0151 [doi] AB - OBJECTIVES: Analyze the ethical duties and dilemmas involved in treating the severely hypothyroid patient. DESIGN: A critical review of the literature was conducted with respect to clinical ethics issues pertaining to severe hypothyroidism; legal and ethical guidelines for consent and capacity in the context of severe hypothyroidism; health case law involving the duty to warn third parties; and comparable clinical conditions resulting in impaired driving and the performance of critical tasks. MAIN OUTCOME: Neuropsychological studies and accepted clinical experiences verify the variable degrees of intellectual and neurological impairment consequent to severe hypothyroidism. Thus, severely hypothyroid patients are considered impaired in the performance of specific tasks, such as driving. Consequent to that, they may be agents of harm as a result of their impairment if they are not warned against driving or performing other duties affecting public safety. Severely hypothyroid patients may lack the capacity to make an informed decision, even when warned against driving or other tasks, and some may ignore such warnings. CONCLUSIONS: The legal and ethical "duty to warn" may trump confidentiality and HIPAA in cases where the activity of impaired patients seriously affects public safety. Not only do health care providers have a clear duty to warn patients not to drive, but in some extreme cases, may have a duty to warn third parties when a patient's driving or occupational duties place the public in harm's way. FAU - Rosenthal, M Sara AU - Rosenthal MS AD - Program for Bioethics and Patients' Rights, University of Kentucky College of Medicine, Lexington, Kentucky 04536-0086, USA. msrose2@email.uky.edu LA - eng PT - Journal Article PT - Review PL - United States TA - Thyroid JT - Thyroid : official journal of the American Thyroid Association JID - 9104317 SB - IM MH - Automobile Driving/psychology MH - Duty to Warn/*ethics/legislation & jurisprudence MH - Ethics, Medical MH - Humans MH - Hypothyroidism/*complications/diagnosis/psychology MH - Psychomotor Disorders/diagnosis/*etiology/psychology MH - Safety MH - Task Performance and Analysis RF - 59 EDAT- 2008/01/08 09:00 MHDA- 2008/02/29 09:00 CRDT- 2008/01/08 09:00 PHST- 2008/01/08 09:00 [pubmed] PHST- 2008/02/29 09:00 [medline] PHST- 2008/01/08 09:00 [entrez] AID - 10.1089/thy.2007.0151 [doi] PST - ppublish SO - Thyroid. 2007 Dec;17(12):1261-7. doi: 10.1089/thy.2007.0151. PMID- 28659257 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2291-9694 (Print) IS - 2291-9694 (Electronic) IS - 2291-9694 (Linking) VI - 5 IP - 2 DP - 2017 Jun 28 TI - Telemedicine Services for the Arctic: A Systematic Review. PG - e16 LID - 10.2196/medinform.6323 [doi] LID - e16 AB - BACKGROUND: Telemedicine services have been successfully used in areas where there are adequate infrastructures such as reliable power and communication lines. However, despite the increasing number of merchants and seafarers, maritime and Arctic telemedicine have had limited success. This might be linked with various factors such as lack of good infrastructure, lack of trained onboard personnel, lack of Arctic-enhanced telemedicine equipment, extreme weather conditions, remoteness, and other geographical challenges. OBJECTIVE: The purpose of this review was to assess and analyze the current status of telemedicine services in the context of maritime conditions, extreme weather (ie, Arctic weather), and remote accidents and emergencies. Moreover, the paper aimed to identify successfully implemented telemedicine services in the Arctic region and in maritime settings and remote emergency situations and present state of the art systems for these areas. Finally, we identified the status quo of telemedicine services in the context of search and rescue (SAR) scenarios in these extreme conditions. METHODS: A rigorous literature search was conducted between September 7 and October 28, 2015, through various online databases. Peer reviewed journals and articles were considered. Relevant articles were first identified by reviewing the title, keywords, and abstract for a preliminary filter with our selection criteria, and then we reviewed full-text articles that seemed relevant. Information from the selected literature was extracted based on some predefined categories, which were defined based on previous research and further elaborated upon via iterative brainstorming. RESULTS: The initial hits were vetted using the title, abstract, and keywords, and we retrieved a total of 471 papers. After removing duplicates from the list, 422 records remained. Then, we did an independent assessment of the articles and screening based on the inclusion and exclusion criteria, which eliminated another 219 papers, leaving 203 relevant papers. After a full-text assessment, 36 articles were left, which were critically analyzed. The inter-rater agreement was measured using Cohen Kappa test, and disagreements were resolved through discussion. CONCLUSIONS: Despite the increasing number of fishermen and other seafarers, Arctic and maritime working conditions are mainly characterized by an absence of access to health care facilities. The condition is further aggravated for fishermen and seafarers who are working in the Arctic regions. In spite of the existing barriers and challenges, some telemedicine services have recently been successfully delivered in these areas. These services include teleconsultation (9/37, 24%), teleradiology (8/37, 22%), teledermatology and tele-education (3/37, 8%), telemonitoring and telecardiology (telesonography) (1/37, 3%), and others (10/37, 27%). However, the use of telemedicine in relation to search and rescue (SAR) services is not yet fully exploited. Therefore, we foresee that these implemented and evaluated telemedicine services will serve as underlying models for the successful implementation of future search and rescue (SAR) services. CI - ©Ashenafi Zebene Woldaregay, Ståle Walderhaug, Gunnar Hartvigsen. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 28.06.2017. FAU - Woldaregay, Ashenafi Zebene AU - Woldaregay AZ AUID- ORCID: 0000-0002-9464-3407 AD - Department of Computer Science, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. FAU - Walderhaug, Ståle AU - Walderhaug S AUID- ORCID: 0000-0002-8192-2060 AD - Department of Computer Science, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. AD - SINTEF Digital, Software Engineering, Safety and Security, Tromsø, Norway. FAU - Hartvigsen, Gunnar AU - Hartvigsen G AUID- ORCID: 0000-0001-8771-9867 AD - Department of Computer Science, University of Tromsø - The Arctic University of Norway, Tromsø, Norway. AD - Norwegian Centre for e-Health Research, University Hospital of North Norway, Tromsø, Norway. LA - eng PT - Journal Article DEP - 20170628 PL - Canada TA - JMIR Med Inform JT - JMIR medical informatics JID - 101645109 PMC - PMC5508113 OTO - NOTNLM OT - accidents OT - arctic regions OT - extreme cold OT - health services accessibility OT - telehealth OT - telemedicine COIS- Conflicts of Interest: None declared. EDAT- 2017/07/01 06:00 MHDA- 2017/07/01 06:01 PMCR- 2017/06/28 CRDT- 2017/06/30 06:00 PHST- 2016/07/06 00:00 [received] PHST- 2017/04/04 00:00 [accepted] PHST- 2016/10/07 00:00 [revised] PHST- 2017/06/30 06:00 [entrez] PHST- 2017/07/01 06:00 [pubmed] PHST- 2017/07/01 06:01 [medline] PHST- 2017/06/28 00:00 [pmc-release] AID - v5i2e16 [pii] AID - 10.2196/medinform.6323 [doi] PST - epublish SO - JMIR Med Inform. 2017 Jun 28;5(2):e16. doi: 10.2196/medinform.6323. PMID- 28394190 OWN - NLM STAT- MEDLINE DCOM- 20170724 LR - 20181202 IS - 1744-7593 (Electronic) IS - 1742-5247 (Linking) VI - 14 IP - 6 DP - 2017 Jun TI - Technology-derived storage solutions for stabilizing insulin in extreme weather conditions I: the ViViCap-1 device. PG - 709-714 LID - 10.1080/17425247.2017.1316261 [doi] AB - BACKGROUND: Injectable life-saving drugs should not be exposed to temperatures <4°C/39°F or >30°C/86°F. Frequently, weather conditions exceed these temperature thresholds in many countries. Insulin is to be kept at 4-8°C/~ 39-47°F until use and once opened, is supposed to be stable for up to 31 days at room temperature (exception: 42 days for insulin levemir). Extremely hot or cold external temperature can lead to insulin degradation in a very short time with loss of its glucose-lowering efficacy. METHODS: Combined chemical and engineering solutions for heat protection are employed in ViViCap-1 for disposable insulin pens. The device works based on vacuum insulation and heat consumption by phase-change material. Laboratory studies with exposure of ViViCap-1 to hot outside conditions were performed to evaluate the device performance. RESULTS: ViViCap-1 keeps insulin at an internal temperature < 29°C/84.2°F for a minimum of 12 h without external power requirement, even when constantly exposed to an outside temperature of 37.8°C/100°F. Bringing the device into an ambient temperature < 26°C/78.8°F reverses the phase-change process and 'recharges' the device for further use. CONCLUSIONS: ViViCap-1 performed within its specifications. The small and convenient device maintains the efficacy and safety of using insulin even when carried under hot weather conditions. FAU - Pfützner, Andreas AU - Pfützner A AD - a Medical Department , Pfützner Science & Health Institute , Mainz , Germany. FAU - Pesach, Gidi AU - Pesach G AD - b R&D Department , TempraMed Inc ., Half Moon Bay , CA , USA. FAU - Nagar, Ron AU - Nagar R AD - b R&D Department , TempraMed Inc ., Half Moon Bay , CA , USA. LA - eng PT - Journal Article DEP - 20170413 PL - England TA - Expert Opin Drug Deliv JT - Expert opinion on drug delivery JID - 101228421 RN - 0 (Insulin) SB - IM MH - Hot Temperature MH - Insulin/*chemistry MH - *Temperature MH - *Weather OTO - NOTNLM OT - Insulin injection OT - drug degradation OT - drug stability OT - extreme weather conditions EDAT- 2017/04/11 06:00 MHDA- 2017/07/25 06:00 CRDT- 2017/04/11 06:00 PHST- 2017/04/11 06:00 [pubmed] PHST- 2017/07/25 06:00 [medline] PHST- 2017/04/11 06:00 [entrez] AID - 10.1080/17425247.2017.1316261 [doi] PST - ppublish SO - Expert Opin Drug Deliv. 2017 Jun;14(6):709-714. doi: 10.1080/17425247.2017.1316261. Epub 2017 Apr 13. PMID- 8823390 OWN - NLM STAT- MEDLINE DCOM- 19961029 LR - 20220317 IS - 0030-5898 (Print) IS - 0030-5898 (Linking) VI - 27 IP - 4 DP - 1996 Oct TI - Epidemiology of work-related musculoskeletal disorders. PG - 679-709 AB - Musculoskeletal disorders are common in the United States. Although precise estimates are not available, most researchers agree that exposure to a combination of work place risk factors is a major contributor to these disorders. Along with personal factors (age, gender, etc.). Epidemiologic studies of workers have associated these disorders with many work-place physical and psychosocial factors. Specific physical factors associated with these disorders include intense, repeated, or sustained exertions, awkward, sustained, or extreme postures of the body, insufficient recovery time, vibration, and cold temperatures. Specific examples of work-place psychosocial factors include monotonous work, time pressure, high work load, lack of peer support, and a poor supervisor-employee relationship. FAU - Hales, T R AU - Hales TR AD - Medical Section, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA. FAU - Bernard, B P AU - Bernard BP LA - eng PT - Journal Article PT - Review PL - United States TA - Orthop Clin North Am JT - The Orthopedic clinics of North America JID - 0254463 SB - IM MH - Carpal Tunnel Syndrome/epidemiology MH - Elbow Joint MH - Humans MH - Low Back Pain/epidemiology MH - Musculoskeletal Diseases/*epidemiology MH - Neck Pain/epidemiology MH - Occupational Diseases/*epidemiology MH - Risk Factors MH - Shoulder Joint MH - Syndrome MH - Tendinopathy/epidemiology MH - Vibration/adverse effects MH - Workplace MH - Wrist Joint RF - 243 EDAT- 1996/10/01 00:00 MHDA- 1996/10/01 00:01 CRDT- 1996/10/01 00:00 PHST- 1996/10/01 00:00 [pubmed] PHST- 1996/10/01 00:01 [medline] PHST- 1996/10/01 00:00 [entrez] PST - ppublish SO - Orthop Clin North Am. 1996 Oct;27(4):679-709. PMID- 35110917 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220204 IS - 0976-3147 (Print) IS - 0976-3155 (Electronic) IS - 0976-3155 (Linking) VI - 13 IP - 1 DP - 2022 Jan TI - Efficacy of Gamma Knife Radiosurgery in Refractory Obsessive-Compulsive Disorder: An Indian Experience. PG - 23-31 LID - 10.1055/s-0041-1740453 [doi] AB - Background  Obsessive-compulsive disorder (OCD) is a chronic debilitating psychiatric condition with adverse impact on patient's sociooccupational health. Refractoriness to pharmacotherapy and psychotherapy is not uncommon. Gamma Knife radiosurgery (GKRS) is the comprehensively used and reviewed treatment modality in refractory OCD worldwide. In India, the past two decades of increasing GKRS availability has failed to create the necessary local awareness of its usefulness in refractory OCD. Limited native literature deepens the problem. Objective  To analyze our experience with GKRS in refractory OCD, and report the safety and efficacy/long-term outcome in patients using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Materials and Methods  A retrospective review of patients receiving GKRS for refractory OCD between 2000 and 2020 was carried out. Case files of the eligible ( n  = 9) patients were reviewed for clinical, radiotherapeutic, and outcome data. Additionally, patients were contacted via telephone to enquire about their experiences, and to obtain retroactive consent for GKRS in June 2021. Information obtained was collated, computed, and analyzed. Results  Male-to-female sex ratio was 8:1. Mean age at the time of GKRS and mean duration of OCD prior to GKRS was 30.1 ± 9.4 and 10.2 ± 5.8 years, respectively. Mean baseline Y-BOCS score was 29.6 ± 4.7. Our first patient received cingulotomy, while the rest underwent anterior capsulotomy. Median margin dose (50% isodose) was 70 Gy. Also, 23.8 ± 7.7 was the mean Y-BOCS score at the last follow-up (median = 30 months). Overall, 44.4% patients showed full/partial response (≥25% reduction in Y-BOCS score) at the last follow-up. In anterior capsulotomy (eight patients), patients with moderate/severe OCD showed better response (4/5 responders) than those with extreme OCD (0/3 responders). Single case of cingulotomy resulted in no response (<25% reduction in Y-BOCS score). No adverse radiation effects were noted. Also, 55.6% patients gave retroactive consent telephonically. Conclusion  GKRS is a safe and effective noninvasive treatment modality for refractory OCD. Ventral anterior capsule is the preferred target. Maximum radiation doses of 120 to 160 Gy are well tolerated. Extremely severe OCD cases fared poorer. Proper awareness about the availability and efficacy of GKRS in refractory OCD is required in India. CI - Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ). FAU - Pattankar, Sanjeev AU - Pattankar S AD - Department of Neurosurgery and Gamma Knife Radiosurgery, Parmanand Deepchand Hinduja Hospital & Medical Research Center, Mumbai, Maharashtra, India. FAU - Sankhe, Milind AU - Sankhe M AD - Department of Neurosurgery and Gamma Knife Radiosurgery, Parmanand Deepchand Hinduja Hospital & Medical Research Center, Mumbai, Maharashtra, India. FAU - Chavda, Kersi AU - Chavda K AD - Department of Psychiatry, Parmanand Deepchand Hinduja Hospital & Medical Research Center, Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20220105 PL - United States TA - J Neurosci Rural Pract JT - Journal of neurosciences in rural practice JID - 101533710 PMC - PMC8803525 OTO - NOTNLM OT - Gamma Knife radiosurgery OT - long-term outcome OT - obsessive-compulsive disorder OT - refractory OCD COIS- Conflict of Interest None declared. EDAT- 2022/02/04 06:00 MHDA- 2022/02/04 06:01 PMCR- 2022/01/01 CRDT- 2022/02/03 05:32 PHST- 2022/02/03 05:32 [entrez] PHST- 2022/02/04 06:00 [pubmed] PHST- 2022/02/04 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 2171884 [pii] AID - 10.1055/s-0041-1740453 [doi] PST - epublish SO - J Neurosci Rural Pract. 2022 Jan 5;13(1):23-31. doi: 10.1055/s-0041-1740453. eCollection 2022 Jan. PMID- 23474634 OWN - NLM STAT- MEDLINE DCOM- 20130617 LR - 20161125 IS - 1824-4785 (Print) IS - 1824-4785 (Linking) VI - 57 IP - 1 DP - 2013 Mar TI - Contemporary approach to diagnosis and treatment of neuroblastoma. PG - 40-52 AB - The diagnostic value of Metaiodobenzylguanidine (MIBG) scintigraphy in the management of neuroblastoma is well established. The specificity of MIBG is virtually 100% and remains the most specific imaging modality. Numerous semi-quantitative scores and guidelines have emerged in the last decade that illustrate standardization of the procedure. Other pharmaceuticals such as norcholesterol derivatives, [111In]pentetreotide and [68Ga]somatostatin analogs, [18F]fluorodeoxyglucose, [18F]fluorodopa, [18F]fluorodopamine, [11C]meta hydroxyephedrine, and [11C] /[18F] /[123I]Metomidate (MTO) have been or are being evaluated currently (including development of new analogues labeled with positron emitting radionuclides such as [124I], [18F], and [76Br]. Radiopharmaceutical therapy of neuroblastoma, initiated over 30 years ago, demonstrates that a significant fraction of patients enter partial remission but complete remission is rare and relapse is frequent. With the combination of chemotherapy, radiosensitizers, and autologous stem cell support, some centers have seen overall response rates of up to 30% in refractory or recurrent diseases. Topoisomerase I inhibitor topotecan may improve upon existing [131I]MIBG therapy. Areas of future development may be in vitro cultures and animal models, proper instrumentation to acquire sub-centimeter resolution and human clinical trials to evaluate treatment at earlier times or stages of disease, evaluation with concomitant immunotherapy with monoclonal antibodies targeting the GD2 ganglioside or inhibitors of anaplastic lymphoma kinase. Because of the complexity of those trials, progress remains extremely slow as well designed multicenter studies are required. Nonetheless, the future has never been so hopeful. FAU - Charron, M AU - Charron M AD - Department of Diagnostic Imaging, University of Toronto, Canada. martin.charron@sickkids.ca LA - eng PT - Journal Article PT - Review PL - Italy TA - Q J Nucl Med Mol Imaging JT - The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... JID - 101213861 RN - 0 (Radiopharmaceuticals) RN - 0 (indium-111-octreotide) RN - 35MRW7B4AD (3-Iodobenzylguanidine) RN - RWM8CCW8GP (Octreotide) SB - IM MH - 3-Iodobenzylguanidine/*therapeutic use MH - Animals MH - Bone and Bones/diagnostic imaging MH - Central Nervous System Neoplasms/diagnostic imaging/therapy MH - Child MH - Child, Preschool MH - Clinical Trials as Topic MH - Diagnostic Imaging/methods MH - Disease Models, Animal MH - Female MH - Humans MH - Infant MH - Kinetics MH - Male MH - Medical Oncology/methods MH - Mice MH - Neuroblastoma/*diagnosis/*therapy MH - Octreotide/analogs & derivatives MH - Patient Safety MH - Radiometry/methods MH - Radionuclide Imaging/methods MH - Radiopharmaceuticals/therapeutic use MH - Recurrence MH - Remission Induction MH - Sensitivity and Specificity MH - Tissue Distribution EDAT- 2013/03/12 06:00 MHDA- 2013/06/19 06:00 CRDT- 2013/03/12 06:00 PHST- 2013/03/12 06:00 [entrez] PHST- 2013/03/12 06:00 [pubmed] PHST- 2013/06/19 06:00 [medline] AID - R39132583 [pii] PST - ppublish SO - Q J Nucl Med Mol Imaging. 2013 Mar;57(1):40-52. PMID- 25488391 OWN - NLM STAT- MEDLINE DCOM- 20151029 LR - 20150124 IS - 1179-1896 (Electronic) IS - 1175-5652 (Linking) VI - 13 IP - 1 DP - 2015 Feb TI - Cost effectiveness of transcatheter aortic valve replacement compared with medical management or surgery for patients with aortic stenosis. PG - 29-45 LID - 10.1007/s40258-014-0141-6 [doi] AB - BACKGROUND: In the symptomatic patient, severe aortic stenosis (AS) has an extremely adverse prognosis in the absence of valve replacement, inevitably leading to deterioration of heart function, heart failure, and death. However, many patients with severe AS, advanced age, and comorbid disease may die with AS rather than from AS. While the results of surgical aortic valve replacement (SAVR) are extremely favorable, this technique is not always possible because of either local- or patient-level contraindications. Over the last decade, transcatheter aortic valve replacement (TAVR) has emerged as a new treatment strategy for selected patients with AS. It has now become the standard of care for extremely high-risk (inoperable) patients with AS, and is an appropriate alternative to surgery in high-risk but operable patients. However, whether this intervention is a cost-effective use of resources is open to question AIM: The aim of this review was to assess the results and quality of the economic evaluations in the current literature and to identify the drivers of cost effectiveness. METHODS: We performed an electronic data search using four different electronic databases, selecting all studies that included cost-effectiveness data for TAVR compared with either medical management or surgery. Sixteen studies were evaluated for a qualitative and quantitative assessment. RESULTS: The quality of the cost-effectiveness analyses (CEAs) were generally sufficient. In contrast, we found an extreme heterogeneity of input assumptions with consequent difficulties to generalize the conclusions. However, in the population of patients with severe symptomatic AS and a prohibitive surgical risk, TAVR generally represents a good choice, with incremental costs that are well balanced by the great benefit in terms of quality of life and survival. Nevertheless, the cost effectiveness of this procedure in the real world, particularly in patients with high healthcare costs from other comorbid conditions, may be less favorable. In AS patients with high (but not prohibitive) surgical risk, the choice between TAVR and SAVR is still debatable. Both procedures are comparable in terms of efficacy and safety but the evidence is inconclusive from an economic point of view. CONCLUSIONS: On the basis of this review, it was ascertained that the details of risk evaluation and patient selection will be critical in understanding how improvements in survival can be used to target the use of TAVR to ensure the cost-effective and sustainable use of resources. FAU - Iannaccone, Andrea AU - Iannaccone A AD - Menzies Research Institute Tasmania, 17 Liverpool St, Hobart, TAS, 7000, Australia. FAU - Marwick, Thomas H AU - Marwick TH LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - New Zealand TA - Appl Health Econ Health Policy JT - Applied health economics and health policy JID - 101150314 SB - IM MH - Aortic Valve Stenosis/*surgery MH - Cost-Benefit Analysis MH - Humans MH - Thoracic Surgical Procedures/*economics MH - Transcatheter Aortic Valve Replacement/*economics EDAT- 2014/12/10 06:00 MHDA- 2015/10/30 06:00 CRDT- 2014/12/10 06:00 PHST- 2014/12/10 06:00 [entrez] PHST- 2014/12/10 06:00 [pubmed] PHST- 2015/10/30 06:00 [medline] AID - 10.1007/s40258-014-0141-6 [doi] PST - ppublish SO - Appl Health Econ Health Policy. 2015 Feb;13(1):29-45. doi: 10.1007/s40258-014-0141-6. PMID- 29637591 OWN - NLM STAT- MEDLINE DCOM- 20181217 LR - 20231213 IS - 1539-6924 (Electronic) IS - 0272-4332 (Linking) VI - 38 IP - 10 DP - 2018 Oct TI - Threshold Evaluation of Emergency Risk Communication for Health Risks Related to Hazardous Ambient Temperature. PG - 2208-2221 LID - 10.1111/risa.12998 [doi] AB - Emergency risk communication (ERC) programs that activate when the ambient temperature is expected to cross certain extreme thresholds are widely used to manage relevant public health risks. In practice, however, the effectiveness of these thresholds has rarely been examined. The goal of this study is to test if the activation criteria based on extreme temperature thresholds, both cold and heat, capture elevated health risks for all-cause and cause-specific mortality and morbidity in the Minneapolis-St. Paul Metropolitan Area. A distributed lag nonlinear model (DLNM) combined with a quasi-Poisson generalized linear model is used to derive the exposure-response functions between daily maximum heat index and mortality (1998-2014) and morbidity (emergency department visits; 2007-2014). Specific causes considered include cardiovascular, respiratory, renal diseases, and diabetes. Six extreme temperature thresholds, corresponding to 1st-3rd and 97th-99th percentiles of local exposure history, are examined. All six extreme temperature thresholds capture significantly increased relative risks for all-cause mortality and morbidity. However, the cause-specific analyses reveal heterogeneity. Extreme cold thresholds capture increased mortality and morbidity risks for cardiovascular and respiratory diseases and extreme heat thresholds for renal disease. Percentile-based extreme temperature thresholds are appropriate for initiating ERC targeting the general population. Tailoring ERC by specific causes may protect some but not all individuals with health conditions exacerbated by hazardous ambient temperature exposure. CI - © 2018 Society for Risk Analysis. FAU - Liu, Yang AU - Liu Y AD - Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities, Minneapolis, MN, USA. FAU - Hoppe, Brenda O AU - Hoppe BO AD - Department of Health, Environmental Health Division, Minnesota, St. Paul, MN, USA. FAU - Convertino, Matteo AU - Convertino M AD - Complexity Group, Division of Frontier Science & Media and Network Technologies, Laboratory of Information Communication Networks, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan. AD - Global Station for Big Data and Cybersecurity, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Sapporo, Japan. LA - eng GR - 5H13EH001125-03/Minnesota Department of Health/International PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20180410 PL - United States TA - Risk Anal JT - Risk analysis : an official publication of the Society for Risk Analysis JID - 8109978 SB - IM MH - Algorithms MH - Cities MH - *Communication MH - Environment MH - *Environmental Exposure MH - *Extreme Cold MH - *Extreme Heat MH - Humans MH - Linear Models MH - Minnesota MH - Nonlinear Dynamics MH - Outcome Assessment, Health Care MH - Poisson Distribution MH - Public Health/*methods MH - Risk Assessment/*methods MH - Safety MH - Seasons MH - Time Factors OTO - NOTNLM OT - Environmental health OT - population health OT - public health intervention OT - risk communication OT - temperature EDAT- 2018/04/11 06:00 MHDA- 2018/12/18 06:00 CRDT- 2018/04/12 06:00 PHST- 2017/08/21 00:00 [received] PHST- 2018/01/25 00:00 [revised] PHST- 2018/03/05 00:00 [accepted] PHST- 2018/04/11 06:00 [pubmed] PHST- 2018/12/18 06:00 [medline] PHST- 2018/04/12 06:00 [entrez] AID - 10.1111/risa.12998 [doi] PST - ppublish SO - Risk Anal. 2018 Oct;38(10):2208-2221. doi: 10.1111/risa.12998. Epub 2018 Apr 10. PMID- 21131698 OWN - NLM STAT- MEDLINE DCOM- 20110323 LR - 20101206 IS - 1943-2720 (Electronic) IS - 0889-5899 (Linking) VI - 56 IP - 11 DP - 2010 Nov TI - Disaster management, triage-based wound care, and patient safety: reflections on practice following an earthquake. PG - 61-9 AB - Triage is the process of prioritizing patient care based on need and available resources. Clinicians in wound clinics triage daily because time and resources never seem to be sufficient. The triage concept is taken to an extreme when a disaster strikes--the clinical goal of patient care transforms from the individual patient to providing the greatest good for the greatest number of patients. Situational awareness of system resources is of paramount importance in a disaster. Planning for surge capacity while simultaneously attending to patients who require immediate attention is a must. The recent earthquake in Haiti provided an opportunity to test those skill sets. Scores of clinicians volunteered their time and expertise, elevating wound care to the status of a clinical division. The experience of providing quality wound care despite a myriad of situational limitations suggests that busy wound clinics can learn valuable lessons from the realm of disaster management. The rate of under- and over-triage in wound clinics can be reduced by utilizing commonly collected outcomes and operational data. Patient safety improves when the hierarchy is flattened, communication is open, checklists are used, debriefings are held, and teamwork is encouraged. Reflecting on the working conditions in Haiti, it is clear that patients and clinicians benefit when success is measured by patient outcomes instead of individual accomplishments. FAU - Ennis, William J AU - Ennis WJ AD - Section of Wound Healing and Tissue Repair, University of Chicago, Chicago, Illinois 60612, USA. w.ennis@comcast.net LA - eng PT - Journal Article PL - United States TA - Ostomy Wound Manage JT - Ostomy/wound management JID - 8912029 MH - *Disaster Planning MH - *Earthquakes MH - Haiti MH - Humans MH - *Safety MH - *Triage MH - Wounds and Injuries/*therapy EDAT- 2010/12/07 06:00 MHDA- 2011/03/24 06:00 CRDT- 2010/12/07 06:00 PHST- 2010/12/07 06:00 [entrez] PHST- 2010/12/07 06:00 [pubmed] PHST- 2011/03/24 06:00 [medline] PST - ppublish SO - Ostomy Wound Manage. 2010 Nov;56(11):61-9. PMID- 32679644 OWN - NLM STAT- MEDLINE DCOM- 20210301 LR - 20210301 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 20 IP - 14 DP - 2020 Jul 15 TI - Malicious UAV Detection Using Integrated Audio and Visual Features for Public Safety Applications. LID - 10.3390/s20143923 [doi] LID - 3923 AB - Unmanned aerial vehicles (UAVs) have become popular in surveillance, security, and remote monitoring. However, they also pose serious security threats to public privacy. The timely detection of a malicious drone is currently an open research issue for security provisioning companies. Recently, the problem has been addressed by a plethora of schemes. However, each plan has a limitation, such as extreme weather conditions and huge dataset requirements. In this paper, we propose a novel framework consisting of the hybrid handcrafted and deep feature to detect and localize malicious drones from their sound and image information. The respective datasets include sounds and occluded images of birds, airplanes, and thunderstorms, with variations in resolution and illumination. Various kernels of the support vector machine (SVM) are applied to classify the features. Experimental results validate the improved performance of the proposed scheme compared to other related methods. FAU - Jamil, Sonain AU - Jamil S AUID- ORCID: 0000-0002-7139-7389 AD - ACTSENA Research Group, Telecommunication Engineering Department, University of Engineering and Technology, Taxila, Punjab 47050, Pakistan. FAU - Fawad AU - Fawad AUID- ORCID: 0000-0002-3860-2635 AD - ACTSENA Research Group, Telecommunication Engineering Department, University of Engineering and Technology, Taxila, Punjab 47050, Pakistan. FAU - Rahman, MuhibUr AU - Rahman M AUID- ORCID: 0000-0002-5084-7862 AD - Department of Electrical Engineering, Polytechnique Montreal, Montreal, QC H3T 1J4, Canada. FAU - Ullah, Amin AU - Ullah A AD - College of Engineering & Computer Science (CECS), Center for Research in Computer Vision Lab (CRCV Lab), University of Central Florida (UCF), Orlando, FL 32816, USA. FAU - Badnava, Salman AU - Badnava S AD - Department of Computer Science and Engineering, College of Engineering, Qatar University, P.O. Box Doha 2713, Qatar. FAU - Forsat, Masoud AU - Forsat M AUID- ORCID: 0000-0002-8563-1324 AD - Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, P.O. Box Doha 2713, Qatar. FAU - Mirjavadi, Seyed Sajad AU - Mirjavadi SS AUID- ORCID: 0000-0001-8833-8273 AD - Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, P.O. Box Doha 2713, Qatar. LA - eng PT - Journal Article DEP - 20200715 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Aircraft MH - Safety MH - *Support Vector Machine PMC - PMC7412104 OTO - NOTNLM OT - AlexNet OT - feature extraction OT - localization OT - malicious drones OT - public safety OT - surveillance COIS- The authors declare that there is no conflict of interest regarding this publication. EDAT- 2020/07/19 06:00 MHDA- 2021/03/02 06:00 PMCR- 2020/07/01 CRDT- 2020/07/19 06:00 PHST- 2020/02/01 00:00 [received] PHST- 2020/02/27 00:00 [revised] PHST- 2020/02/29 00:00 [accepted] PHST- 2020/07/19 06:00 [entrez] PHST- 2020/07/19 06:00 [pubmed] PHST- 2021/03/02 06:00 [medline] PHST- 2020/07/01 00:00 [pmc-release] AID - s20143923 [pii] AID - sensors-20-03923 [pii] AID - 10.3390/s20143923 [doi] PST - epublish SO - Sensors (Basel). 2020 Jul 15;20(14):3923. doi: 10.3390/s20143923. PMID- 39282914 OWN - NLM STAT- Publisher LR - 20241022 IS - 1475-990X (Electronic) IS - 1473-9879 (Linking) DP - 2024 Sep 16 TI - Teaching patient safety in remote consulting. PG - 1-4 LID - 10.1080/14739879.2024.2383457 [doi] AB - A significant proportion of primary care consultations now happen remotely. Although the vast majority occur safely, a recent study highlighted areas of risk which may be compounded by the limited training many GPs have received in remote consulting. To provide safe remote services, consideration needs to be given to adapting practice workflow to optimise remote care. Patients less suitable for remote consulting, either due to disease, extremes of age, disability or for social reasons should be identified and prioritised for face-to-face encounters. Training supports both the development of individual communication skills for remote care, and effective team working. Practice-based group learning events can be used to share experiences, identify resources, and consider the risks in remote care and how they can be mitigated. The paper presents some fictionalised cases, illustrating where patients came to harm, as a result of a remote consultation, and where harm was averted due to actions taken by practice teams. These can be used to support critical thinking and discussion within practice development meetings and tutorials with trainee GPs and other practice staff. Using the paper as a basis for reflection, teaching and action can facilitate the delivery of safer remote care. FAU - King, Kate AU - King K AUID- ORCID: 0000-0002-1016-5357 AD - Department of Military General Practice, Research & Clinical Innovation, Defence Medical Services, Birmingham, UK. FAU - Payne, Rebecca AU - Payne R AUID- ORCID: 0000-0002-8954-7584 AD - Department of Primary Health Care Sciences, University of Oxford, Oxford, UK. LA - eng PT - Journal Article DEP - 20240916 PL - England TA - Educ Prim Care JT - Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors JID - 101141280 SB - IM OTO - NOTNLM OT - Primary care OT - education OT - general practice OT - safety OT - training EDAT- 2024/09/17 10:46 MHDA- 2024/09/17 10:46 CRDT- 2024/09/16 07:33 PHST- 2024/09/17 10:46 [pubmed] PHST- 2024/09/17 10:46 [medline] PHST- 2024/09/16 07:33 [entrez] AID - 10.1080/14739879.2024.2383457 [doi] PST - aheadofprint SO - Educ Prim Care. 2024 Sep 16:1-4. doi: 10.1080/14739879.2024.2383457. PMID- 27446165 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160722 LR - 20240325 IS - 1664-462X (Print) IS - 1664-462X (Electronic) IS - 1664-462X (Linking) VI - 7 DP - 2016 TI - Response and Tolerance Mechanism of Cotton Gossypium hirsutum L. to Elevated Temperature Stress: A Review. PG - 937 LID - 10.3389/fpls.2016.00937 [doi] LID - 937 AB - Cotton is an important multipurpose crop which is highly sensitive to both biotic and abiotic stresses. Proper management of this cash crop requires systematic understanding of various environmental conditions that are vital to yield and quality. High temperature stress can severely affect the viability of pollens and anther indehiscence, which leads to significant yield losses. Cotton can respond to withstand adverse environmental condition in several phases among which the accumulation of chemicals is extremely vital. Calcium, kinases, reactive oxygen species, carbohydrate, transcription factors, gene expression regulation, and plant hormones signaling pathways are playing a handy role in activating the major genes responsible to encounter and defend elevated temperature stress. The production of heat shock proteins is up-regulated when crops are unleashed to high temperature stress. Molecular breeding can play a functional role to identify superior genes for all the important attributes as well as provide breeder ready markers for developing ideotypes. The development of high-temperature resistant transgenic cultivars of cotton can grant a stability benefit and can also ameliorate the production capacity in response to elevated temperature. FAU - Zahid, Kashif Rafiq AU - Zahid KR AD - Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University Wuhan, China. FAU - Ali, Farhan AU - Ali F AD - Cereal Crops Research Institute Pirsabak, Nowshera, Pakistan. FAU - Shah, Farooq AU - Shah F AD - Department of Agriculture, Abdul Wali Khan University Mardan Khyber Pakhtunkhwa, Pakistan. FAU - Younas, Muhammad AU - Younas M AD - Department of Biotechnology, Mohi-ud-Din Islamic University Azad Jammu and Kashmir, Pakistan. FAU - Shah, Tariq AU - Shah T AD - Department of Agricultural Economics and Management, Huazhong Agricultural University Wuhan, China. FAU - Shahwar, Durri AU - Shahwar D AD - Department of Plant Breeding and Genetics, University of Swabi Khyber Pakhtunkhwa, Pakistan. FAU - Hassan, Waseem AU - Hassan W AD - Department of Soil and Environmental Sciences, Muhammad Nawaz Shareef University of Agriculture Multan, Pakistan. FAU - Ahmad, Zahoor AU - Ahmad Z AD - Key Lab of Crop Disease Monitoring and Safety Control, Huazhong Agricultural University Wuhan, China. FAU - Qi, Chao AU - Qi C AD - Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University Wuhan, China. FAU - Lu, Yanli AU - Lu Y AD - Maize Research Institute, Sichuan Agricultural University Wenjian Sichuan, China. FAU - Iqbal, Amjad AU - Iqbal A AD - Department of Agriculture, Abdul Wali Khan University Mardan Khyber Pakhtunkhwa, Pakistan. FAU - Wu, Wei AU - Wu W AD - College of Agronomy, Northwest A&F University Yangling, China. LA - eng PT - Journal Article PT - Review DEP - 20160630 PL - Switzerland TA - Front Plant Sci JT - Frontiers in plant science JID - 101568200 PMC - PMC4927942 OTO - NOTNLM OT - abscisic acid OT - cotton OT - heat stress OT - signal transduction EDAT- 2016/07/23 06:00 MHDA- 2016/07/23 06:01 PMCR- 2016/01/01 CRDT- 2016/07/23 06:00 PHST- 2016/02/10 00:00 [received] PHST- 2016/06/13 00:00 [accepted] PHST- 2016/07/23 06:00 [entrez] PHST- 2016/07/23 06:00 [pubmed] PHST- 2016/07/23 06:01 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - 10.3389/fpls.2016.00937 [doi] PST - epublish SO - Front Plant Sci. 2016 Jun 30;7:937. doi: 10.3389/fpls.2016.00937. eCollection 2016. PMID- 37890433 OWN - NLM STAT- MEDLINE DCOM- 20231127 LR - 20231127 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 194 DP - 2024 Jan TI - Toward safer highway work zones: An empirical analysis of crash risks using improved safety potential field and machine learning techniques. PG - 107361 LID - S0001-4575(23)00408-6 [pii] LID - 10.1016/j.aap.2023.107361 [doi] AB - Due to complex traffic conditions, transition areas in highway work zones are associated with a higher crash risk than other highway areas. Understanding risk-contributing features in transition areas is essential for ensuring traffic safety on highways. However, conventional surrogate safety measures (SSMs) are quite limited in identifying the crash risk in transition areas due to the complex traffic environment. To this end, this study proposes an improved safety potential field, named the Work-Zone Crash Risk Field (WCRF). The WCRF force can be used to measure the crash risk of individual vehicles that enter a work zone considering the influence of multiple features, upon which the overall crash risk of the road segment in a specific time window can be estimated. With the overall crash risk used as a label, the time-window-based traffic data are used to train and validate an eXtreme Gradient Boosting (XGBoost) classifier, and the Shapley Additive Explanations (SHAP) method is integrated with the XGBoost classifier to identify the key risk-contributing traffic features. To assess the proposed approach, a case study is conducted using real-time vehicle trajectory data collected in two work zones along a highway in China. The results demonstrate that the WCRF-based SSM outperforms conventional SSMs in identifying crash risks in work zone transition areas on highways. In addition, we perform lane-based analysis regarding the impact of setting up work zones on highway safety and investigate the heterogeneity in risk-contributing features across different work zones. Several interesting findings from the analysis are reported in this paper. Compared to existing SSMs, the WCRF-based SSM offers a more practical and comprehensive way to describe the crash risk in work zones. The approach using the developed WCRF technique offers improved capabilities in identifying key risk-contributing features, which is expected to facilitate the development of safety management strategies for work zones. CI - Copyright © 2023. Published by Elsevier Ltd. FAU - Wang, Bo AU - Wang B AD - School of Highway, Chang'An University, Xi'an 710064, China; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore; Engineering Research Center of Highway Infrastructure Digitalization, Ministry of Education, Xi'an 710000, China. FAU - Chen, Tianyi AU - Chen T AD - School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore; Department of Civil and Environmental Engineering, National University of Singapore, Singapore 117576, Singapore. FAU - Zhang, Chi AU - Zhang C AD - School of Highway, Chang'An University, Xi'an 710064, China; Engineering Research Center of Highway Infrastructure Digitalization, Ministry of Education, Xi'an 710000, China. Electronic address: zhangchi@chd.edu.cn. FAU - Wong, Yiik Diew AU - Wong YD AD - School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore. FAU - Zhang, Hong AU - Zhang H AD - Transportation Institute, Inner Mongolia University, Hohhot 010021, China. FAU - Zhou, Yunhao AU - Zhou Y AD - School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore. LA - eng PT - Journal Article DEP - 20231025 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Humans MH - *Accidents, Traffic/prevention & control MH - *Automobile Driving MH - Safety MH - Risk Factors MH - Safety Management MH - China OTO - NOTNLM OT - Improved crash risk field OT - Key risk-contributing features OT - Machine learning OT - Real-time trajectory data OT - Work zone safety COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/28 11:42 MHDA- 2023/11/27 12:42 CRDT- 2023/10/27 18:10 PHST- 2023/07/18 00:00 [received] PHST- 2023/10/07 00:00 [revised] PHST- 2023/10/18 00:00 [accepted] PHST- 2023/11/27 12:42 [medline] PHST- 2023/10/28 11:42 [pubmed] PHST- 2023/10/27 18:10 [entrez] AID - S0001-4575(23)00408-6 [pii] AID - 10.1016/j.aap.2023.107361 [doi] PST - ppublish SO - Accid Anal Prev. 2024 Jan;194:107361. doi: 10.1016/j.aap.2023.107361. Epub 2023 Oct 25. PMID- 27760844 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) VI - 9 IP - 1 DP - 2017 Jan/Feb TI - Injuries in an Extreme Conditioning Program. PG - 52-58 LID - 10.1177/1941738116674895 [doi] AB - BACKGROUND: Extreme conditioning programs (ECPs) are fitness training regimens relying on aerobic, plyometric, and resistance training exercises, often with high levels of intensity for a short duration of time. These programs have grown rapidly in popularity in recent years, but science describing the safety profile of these programs is lacking. HYPOTHESIS: The rate of injury in the extreme conditioning program is greater than the injury rate of weightlifting and the majority of injuries occur to the shoulder and back. STUDY DESIGN: Cross-sectional study. LEVEL OF EVIDENCE: Level 4. METHODS: This is a retrospective survey of injuries reported by athletes participating in an ECP. An injury survey was sent to 1100 members of Iron Tribe Fitness, a gym franchise with 5 locations across Birmingham, Alabama, that employs exercises consistent with an ECP in this study. An injury was defined as a physical condition resulting from ECP participation that caused the athlete to either seek medical treatment, take time off from exercising, or make modifications to his or her technique to continue. RESULTS: A total of 247 athletes (22%) completed the survey. The majority (57%) of athletes were male (n = 139), and 94% of athletes were white (n = 227). The mean age of athletes was 38.9 years (±8.9 years). Athletes reported participation in the ECP for, on average, 3.6 hours per week (± 1.2 hours). Eighty-five athletes (34%) reported that they had sustained an injury while participating in the ECP. A total of 132 injuries were recorded, yielding an estimated incidence of 2.71 per 1000 hours. The shoulder or upper arm was the most commonly injured body site, accounting for 38 injuries (15% of athletes). Athletes with a previous shoulder injury were 8.1 times as likely to injure their shoulder in the ECP compared with athletes with healthy shoulders. The trunk, back, head, or neck (n = 29, 12%) and the leg or knee (n = 29, 12%) were the second most commonly injured sites. The injury incidence rate among athletes with <6 months of experience in the ECP was 2.5 times greater than that of more experienced athletes (≥6 months of experience). Of the 132 injuries, 23 (17%) required surgical intervention. Squat cleans, ring dips, overhead squats, and push presses were more likely to cause injury. Athletes reported that 35% of injuries were due to overexertion and 20% were due to improper technique. CONCLUSION: The estimated injury rate among athletes participating in this ECP was similar to the rate of injury in weightlifting and most other recreational activities. The shoulder or upper arm was the most commonly injured area, and previous shoulder injury predisposed to new shoulder injury. New athletes are at considerable risk of injury compared with more experienced athletes. CLINICAL RELEVANCE: Extreme conditioning programs are growing in popularity, and there is disagreement between science and anecdotal reports from athletes, coaches, and physicians about their relative safety. This study estimates the incidence of injury in extreme conditioning programs, which appears to be similar to other weight-training programs. FAU - Aune, Kyle T AU - Aune KT AD - American Sports Medicine Institute, Birmingham, Alabama. FAU - Powers, Joseph M AU - Powers JM AD - American Sports Medicine Institute, Birmingham, Alabama. LA - eng PT - Journal Article DEP - 20161021 PL - United States TA - Sports Health JT - Sports health JID - 101518422 CIN - Sports Health. 2018 Sep/Oct;10(5):468. doi: 10.1177/1941738118788538. PMID: 30153100 PMC - PMC5315259 OTO - NOTNLM OT - CrossFit OT - epidemiology OT - extreme conditioning program OT - injury COIS- The authors report no potential conflicts of interest in the development and publication of this article. EDAT- 2016/10/21 06:00 MHDA- 2016/10/21 06:01 PMCR- 2017/10/21 CRDT- 2016/10/21 06:00 PHST- 2016/10/21 06:00 [pubmed] PHST- 2016/10/21 06:01 [medline] PHST- 2016/10/21 06:00 [entrez] PHST- 2017/10/21 00:00 [pmc-release] AID - 1941738116674895 [pii] AID - 10.1177_1941738116674895 [pii] AID - 10.1177/1941738116674895 [doi] PST - ppublish SO - Sports Health. 2017 Jan/Feb;9(1):52-58. doi: 10.1177/1941738116674895. Epub 2016 Oct 21. PMID- 25612827 OWN - NLM STAT- MEDLINE DCOM- 20170117 LR - 20170117 IS - 1549-7828 (Electronic) IS - 1040-841X (Linking) VI - 42 IP - 4 DP - 2016 Aug TI - Effects of climate change on the persistence and dispersal of foodborne bacterial pathogens in the outdoor environment: A review. PG - 548-72 LID - 10.3109/1040841X.2014.972335 [doi] AB - According to the Intergovernmental Panel on Climate Change (IPCC), warming of the climate system is unequivocal. Over the coming century, warming trends such as increased duration and frequency of heat waves and hot extremes are expected in some areas, as well as increased intensity of some storm systems. Climate-induced trends will impact the persistence and dispersal of foodborne pathogens in myriad ways, especially for environmentally ubiquitous and/or zoonotic microorganisms. Animal hosts of foodborne pathogens are also expected to be impacted by climate change through the introduction of increased physiological stress and, in some cases, altered geographic ranges and seasonality. This review article examines the effects of climatic factors, such as temperature, rainfall, drought and wind, on the environmental dispersal and persistence of bacterial foodborne pathogens, namely, Bacillus cereus, Brucella, Campylobacter, Clostridium, Escherichia coli, Listeria monocytogenes, Salmonella, Staphylococcus aureus, Vibrio and Yersinia enterocolitica. These relationships are then used to predict how future climatic changes will impact the activity of these microorganisms in the outdoor environment and associated food safety issues. The development of predictive models that quantify these complex relationships will also be discussed, as well as the potential impacts of climate change on transmission of foodborne disease from animal hosts. FAU - Hellberg, Rosalee S AU - Hellberg RS AD - a Food Science and Nutrition Program, Schmid College of Science and Technology, Chapman University , Orange , CA , USA. FAU - Chu, Eric AU - Chu E AD - a Food Science and Nutrition Program, Schmid College of Science and Technology, Chapman University , Orange , CA , USA. LA - eng PT - Journal Article PT - Review DEP - 20150123 PL - England TA - Crit Rev Microbiol JT - Critical reviews in microbiology JID - 8914274 SB - IM MH - Animals MH - Bacteria/*isolation & purification/pathogenicity MH - *Climate Change MH - *Environmental Microbiology MH - *Food Safety MH - Foodborne Diseases/*microbiology MH - Humans MH - Models, Theoretical MH - Zoonoses/*microbiology OTO - NOTNLM OT - Climate change OT - food safety OT - foodborne pathogens OT - predictive models OT - zoonotic pathogens EDAT- 2015/01/24 06:00 MHDA- 2017/01/18 06:00 CRDT- 2015/01/24 06:00 PHST- 2015/01/24 06:00 [entrez] PHST- 2015/01/24 06:00 [pubmed] PHST- 2017/01/18 06:00 [medline] AID - 10.3109/1040841X.2014.972335 [doi] PST - ppublish SO - Crit Rev Microbiol. 2016 Aug;42(4):548-72. doi: 10.3109/1040841X.2014.972335. Epub 2015 Jan 23. PMID- 23519691 OWN - NLM STAT- MEDLINE DCOM- 20140114 LR - 20220316 IS - 2242-3982 (Electronic) IS - 1239-9736 (Print) IS - 1239-9736 (Linking) VI - 72 DP - 2013 TI - Occupational health and health care in Russia and Russian Arctic: 1980-2010. PG - 20456 LID - 10.3402/ijch.v72i0.20456 [doi] AB - BACKGROUND: There is a paradox in Russia and its Arctic regions which reports extremely low rates of occupational diseases (ODs), far below those of other socially and economically advanced circumpolar countries. Yet, there is widespread disregard for occupational health regulations and neglect of basic occupational health services across many industrial enterprises. STUDY DESIGN AND METHODS: This review article presents official statistics and summarises the results of a search of peer-reviewed scientific literature published in Russia on ODs and occupational health care in Russia and the Russian Arctic, within the period 1980-2010. RESULTS: Worsening of the economic situation, layoff of workers, threat of unemployment and increased work load happened during the "wild market" industrial restructuring in 1990-2000, when the health and safety of workers were of little concern. Russian employers are not legally held accountable for neglecting safety rules and for underreporting of ODs. Almost 80% of all Russian industrial enterprises are considered dangerous or hazardous for health. Hygienic control of working conditions was minimised or excluded in the majority of enterprises, and the health status of workers remains largely unknown. There is direct evidence of general degradation of the occupational health care system in Russia. The real levels of ODs in Russia are estimated to be at least 10-100 times higher than reported by official statistics. The low official rates are the result of deliberate hiding of ODs, lack of coverage of working personnel by properly conducted medical examinations, incompetent management and the poor quality of staff, facilities and equipment. CONCLUSIONS: Reform of the Russian occupational health care system is urgently needed, including the passing of strong occupational health legislation and their enforcement, the maintenance of credible health monitoring and effective health services for workers, improved training of occupational health personnel, protection of sanitary-hygienic laboratories in industrial enterprises, and support for research assessing occupational risk and the effectiveness of interventions. FAU - Dudarev, Alexey A AU - Dudarev AA AD - Hygiene Department, Northwest Public Health Research Centre, St. Petersburg, Russia. alexey.d@inbox.ru FAU - Odland, Jon Øyvind AU - Odland JØ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130319 PL - United States TA - Int J Circumpolar Health JT - International journal of circumpolar health JID - 9713056 SB - IM MH - Arctic Regions/epidemiology MH - *Industry MH - Occupational Diseases/*epidemiology MH - Occupational Health/*statistics & numerical data MH - Occupational Health Services/standards/*statistics & numerical data MH - Population Surveillance MH - Russia/epidemiology MH - Safety Management/standards/*statistics & numerical data PMC - PMC3604356 OTO - NOTNLM OT - Russian Arctic OT - labour conditions OT - occupational diseases OT - occupational health care OT - occupational safety EDAT- 2013/03/23 06:00 MHDA- 2014/01/15 06:00 PMCR- 2013/01/01 CRDT- 2013/03/23 06:00 PHST- 2013/03/23 06:00 [entrez] PHST- 2013/03/23 06:00 [pubmed] PHST- 2014/01/15 06:00 [medline] PHST- 2013/01/01 00:00 [pmc-release] AID - 20456 [pii] AID - 10.3402/ijch.v72i0.20456 [doi] PST - ppublish SO - Int J Circumpolar Health. 2013;72:20456. doi: 10.3402/ijch.v72i0.20456. Epub 2013 Mar 19. PMID- 20101935 OWN - NLM STAT- MEDLINE DCOM- 20100223 LR - 20100127 IS - 0028-2200 (Print) IS - 0028-2200 (Linking) VI - 116 IP - 12 DP - 2009 Dec TI - [Elderly people and removable partial dentures]. PG - 665-8 AB - The most frequently reported disadvantages of removable partial dentures are the more demanding daily oral hygiene self-care, especially for people who already experience difficulties in self-care, and the possible harmful influence on the remaining dentition. These disadvantages can be expressed in an extreme form in (frail) elderly people. The elderly show relatively large amounts of oral plaque, (root) caries, and periodontal disease. Considerations which may or may not indicate a partial denture for a (frail) elderly person are: the expressed problem and demand for treatment, the general health condition ofthe patient, oral mucosal health, the condition of the opposing jaw, the possible contribution to function and/or aesthetics, the possibilities of oral self-care and/or volunteer aid, the patient's personal adaptability, and possible hazards. Extreme care in subsequent, decisions should be the rule. Key concepts are: explicit demand for treatment, appropriateness, safety, and oral self-care/volunteer aid. FAU - de Baat, C AU - de Baat C AD - Afdeling Orale Functieleer, Universitair Medisch Centrum St Radboud, Nijmegen. c.debaat@dent.umcn.nI LA - dut PT - English Abstract PT - Journal Article PT - Review TT - Ouderen en partiële gebitsprothesen. PL - Netherlands TA - Ned Tijdschr Tandheelkd JT - Nederlands tijdschrift voor tandheelkunde JID - 0400771 MH - Aged MH - Aged, 80 and over MH - *Dental Care for Aged MH - Dental Caries/complications MH - Dental Plaque Index MH - *Denture, Partial, Removable MH - Frail Elderly MH - Gingival Recession/complications MH - Humans MH - Jaw, Edentulous, Partially/*rehabilitation MH - Oral Health MH - *Oral Hygiene MH - Periodontal Diseases/complications MH - Root Caries/complications MH - Tooth Diseases/complications RF - 32 EDAT- 2010/01/28 06:00 MHDA- 2010/02/24 06:00 CRDT- 2010/01/28 06:00 PHST- 2010/01/28 06:00 [entrez] PHST- 2010/01/28 06:00 [pubmed] PHST- 2010/02/24 06:00 [medline] PST - ppublish SO - Ned Tijdschr Tandheelkd. 2009 Dec;116(12):665-8. PMID- 31215206 OWN - NLM STAT- MEDLINE DCOM- 20191230 LR - 20191230 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 70 IP - 2 DP - 2019 TI - Assessment of changes in the occurrence of Fusarium toxin and ochratoxin A in Poland related to extreme weather phenomena. PG - 127-135 AB - BACKGROUND: Mycotoxins – substances harmful to humans, are ubiquitous in the environment. Mycotoxins are generated primarily by Penicilium, Aspergillus and Fusarium genus fungi. Their presence is associated with the unavoidable presence of mold fungi in the environment. The presently observed adverse climatic changes could negatively affect agriculture, causing erosion and loss of organic matter from soil, promulgation of pests and plant diseases, including those originating from pathogenic molds, and also migration of certain mold species into new regions, ultimately creating more favorable conditions for generation of mycotoxins. OBJECTIVE: The purpose of this work was to investigate contamination of cereals in Poland with Fusarium and ochratoxin A. Elucidating a correlation between precipitation levels in the individual Provinces and reported levels of the investigated mycotoxins, referring to the generally available meteorological databases, would result in more efficient planning of sampling processes and focusing further preventive actions associated with establishing sampling plans for the following years. MATERIAL AND METHODS: Investigations were performed on cereal and cereal product samples taken by the official foodstuffs inspection staff. Some 100 samples were taken annually in the 2009-2012 period (357 samples in total). Tests were performed using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS/MS). Precipitation data were obtained from the Central Office of Statistics, based on data received from the Institute of Meteorology and Water Management. RESULTS: Analysis of the influence of precipitation levels during vegetation period on mycotoxin levels in the investigated foodstuffs was performed by associating each recorded content of deoxynivalenol (n=52, corresponding to 14.6% tested samples), zearalenone (n=30, 8.4%), total T-2 and HT-2 toxins (n=21, 5.9%) and ochratoxin A (n=88, 24.6%) above quantification limit with precipitation levels within the Province from which the sample originated. Deoxynivalenol and zearalenone levels show distinct variability corresponding with variability of precipitation levels, well reflecting the reported higher deoxynivalenol and zearalenone levels observed during the rainy years of 2011-2012. Variability in average ochratoxin A levels was not statistically significant. The relatively higher mycotoxin levels in 2009 may result from the heavy rainfall and flooding of 2007-2008. Dependence between the precipitation levels and number of samples showing levels above quantification limit has been also observed for deoxynivalenol. However, a similar analysis made for zearalenone and ochratoxin A does not point to any significant relationship. No data analysis was possible in reference to total T-2 and HT-2 toxins content due to the insufficient number of results available. However, it should be noted that 21% analyzed samples in 2009 contained T-2 and HT-2 levels above the quantification limit, with average of 8.9 μg/kg, whereas in 2010-2012 only one sample of the 263 tested contained contaminants in quantities above the quantification limit. CONCLUSIONS: The model used for forecasting presence of mycotoxins in cereals does not allow its practical application during routine generation of official control and monitoring plans on national scale. Notably, tests performed show that exceeding of maximum contamination levels occurred just incidentally, notwithstanding the adverse weather conditions. Further systematic collection of data on mycotoxin contamination of agricultural crops is required for effective continued investigations. FAU - Postupolski, Jacek AU - Postupolski J AD - National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland FAU - Starski, Andrzej AU - Starski A AD - National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland FAU - Ledzion, Ewa AU - Ledzion E AD - National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland FAU - Kurpińska-Jaworska, Jolanta AU - Kurpińska-Jaworska J AD - National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland FAU - Szczęsna, Małgorzata AU - Szczęsna M AD - National Institute of Public Health-National Institute of Hygiene, Department of Food Safety, Warsaw, Poland LA - eng PT - Journal Article PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 RN - 0 (Ochratoxins) RN - 1779SX6LUY (ochratoxin A) SB - IM MH - Chromatography, High Pressure Liquid MH - Crops, Agricultural/chemistry MH - Edible Grain/*chemistry MH - *Extreme Weather MH - Food Analysis/methods MH - Food Contamination/analysis MH - Fusarium/*isolation & purification MH - Humans MH - Ochratoxins/*analysis MH - Poland OTO - NOTNLM OT - *mycotoxins OT - *cereal products OT - *formation OT - *weather condition OT - *prediction OT - *Fusarium toxin OT - *ochratoxin A EDAT- 2019/06/20 06:00 MHDA- 2019/12/31 06:00 CRDT- 2019/06/20 06:00 PHST- 2019/06/20 06:00 [entrez] PHST- 2019/06/20 06:00 [pubmed] PHST- 2019/12/31 06:00 [medline] AID - 10.32394/rpzh.2019.0062 [doi] PST - ppublish SO - Rocz Panstw Zakl Hig. 2019;70(2):127-135. doi: 10.32394/rpzh.2019.0062. PMID- 17317552 OWN - NLM STAT- MEDLINE DCOM- 20070508 LR - 20181201 IS - 1064-7406 (Print) IS - 1064-7406 (Linking) VI - 15 IP - 1 DP - 2007 Feb TI - Diagnosis, impact, and management of focal hyperhidrosis: treatment review including botulinum toxin therapy. PG - 17-30, v-vi AB - Idiopathic localized hyperhidrosis, called for hyperhidrosis, affects almost 3% of the US population. The most frequent anatomic sites of involvement include the axillae, palms, soles, and face. For those affected, this condition can be extremely socially debilitating and interfere with work activities. Until recently, frequently ineffective topical regimens or problematic surgical procedures have been the treatments of choice. Since 1996, intracutaneous injections of botulinum toxin have been used as a minimally invasive treatment for this condition with numerous studies documenting safety, efficacy, and extremely high levels of patient satisfaction. Botulinum toxin type A (Botox) was approved by the US Food and Drug Administration in 2004 for the treatment of axillary hyperhidrosis. FAU - Cohen, Joel L AU - Cohen JL AD - AboutSkin Dermatology and DermSurgery, Englewood, CO 80113, USA. denverskindoc@yahoo.com FAU - Cohen, Goldie AU - Cohen G FAU - Solish, Nowell AU - Solish N FAU - Murray, Christian A AU - Murray CA LA - eng PT - Journal Article PT - Review PL - United States TA - Facial Plast Surg Clin North Am JT - Facial plastic surgery clinics of North America JID - 9414907 RN - 0 (Aldehydes) RN - 0 (Aluminum Compounds) RN - 0 (Anesthetics) RN - 0 (Chlorides) RN - 0 (Cholinergic Antagonists) RN - 0 (Neuromuscular Agents) RN - 3CYT62D3GA (Aluminum Chloride) RN - EC 3.4.24.69 (Botulinum Toxins, Type A) SB - IM MH - Aldehydes/therapeutic use MH - Aluminum Chloride MH - Aluminum Compounds/therapeutic use MH - Anesthetics/therapeutic use MH - Botulinum Toxins, Type A/*therapeutic use MH - Chlorides/therapeutic use MH - Cholinergic Antagonists/therapeutic use MH - Complementary Therapies MH - Humans MH - Hyperhidrosis/*diagnosis/*drug therapy/therapy MH - Iontophoresis MH - Neuromuscular Agents/*therapeutic use MH - Sympathectomy RF - 117 EDAT- 2007/02/24 09:00 MHDA- 2007/05/09 09:00 CRDT- 2007/02/24 09:00 PHST- 2007/02/24 09:00 [pubmed] PHST- 2007/05/09 09:00 [medline] PHST- 2007/02/24 09:00 [entrez] AID - S1064-7406(06)00101-5 [pii] AID - 10.1016/j.fsc.2006.10.002 [doi] PST - ppublish SO - Facial Plast Surg Clin North Am. 2007 Feb;15(1):17-30, v-vi. doi: 10.1016/j.fsc.2006.10.002. PMID- 30285276 OWN - NLM STAT- MEDLINE DCOM- 20200413 LR - 20200413 IS - 1552-4604 (Electronic) IS - 0091-2700 (Linking) VI - 59 IP - 1 DP - 2019 Jan TI - Dabigatran as a Treatment Option for Heparin-Induced Thrombocytopenia. PG - 107-111 LID - 10.1002/jcph.1300 [doi] AB - Heparin-induced thrombocytopenia (HIT) is a potentially serious adverse drug reaction that can result in lethal vascular thrombosis. Dabigatran is a direct thrombin inhibitor that might be useful in the management of HIT. This study evaluated the efficacy and safety of dabigatran in patients with HIT. We included 43 patients in the study who received dabigatran for the management of suspected HIT, based on 4Ts (thrombocytopenia, timing of platelet count drop, thrombosis or other sequelae, and other causes of thrombocytopenia) scores. Three patients were excluded because they had received dabigatran with a creatinine clearance <15 mL/min. Patients' records were analyzed longitudinally, with 12 months follow-up from the time of initiation of dabigatran, for occurrence of thrombosis, dabigatran-related complications, and outcome. Patients with chronic kidney disease, hepatic impairment, mechanical heart valves, active bleeding, and extremes of weights (<50 and >120 kg) were excluded from the study. Arterial thrombosis was not observed in any of our patients. The platelet counts normalized in all patients except for 2, which was attributed to the underlying comorbidities. We did not observe any hemorrhagic events or significant thrombosis during the follow-up period. Eight patients died from nonthrombotic causes, which were unrelated to adverse effects of dabigatran. Based on our findings, dabigatran could be considered a safe and effective agent in the management of HIT, particularly in the developing countries, where there could be issues with the cost and availability of other agents recommended for this condition. Further studies are needed to validate our findings. CI - © 2018, The American College of Clinical Pharmacology. FAU - Nasiripour, Somayyeh AU - Nasiripour S AD - Department of Clinical Pharmacy, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran. FAU - Saif, Maryam AU - Saif M AD - Department of Internal Medicine, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Farasatinasab, Maryam AU - Farasatinasab M AD - Department of Clinical Pharmacy, Firoozgar Clinical Research Development Center, School of Pharmacy-International Campus, Iran University of Medical Sciences, Tehran, Iran. FAU - Emami, Sepide AU - Emami S AD - Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran. FAU - Amouzegar, Atefeh AU - Amouzegar A AD - Department of Nephrology, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Basi, Ali AU - Basi A AD - Department of Hematology, Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran. FAU - Mokhtari, Majid AU - Mokhtari M AD - Department of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20181004 PL - England TA - J Clin Pharmacol JT - Journal of clinical pharmacology JID - 0366372 RN - 0 (Anticoagulants) RN - 9005-49-6 (Heparin) RN - I0VM4M70GC (Dabigatran) SB - IM MH - Aged MH - Aged, 80 and over MH - Anticoagulants/*adverse effects/*therapeutic use MH - Dabigatran/adverse effects/*therapeutic use MH - Female MH - Heparin/*adverse effects MH - Humans MH - Male MH - Middle Aged MH - Thrombocytopenia/chemically induced/*drug therapy OTO - NOTNLM OT - HIT OT - dabigatran OT - heparin-induced thrombocytopenia OT - thrombin inhibitor EDAT- 2018/10/05 06:00 MHDA- 2020/04/14 06:00 CRDT- 2018/10/05 06:00 PHST- 2018/06/18 00:00 [received] PHST- 2018/07/23 00:00 [accepted] PHST- 2018/10/05 06:00 [pubmed] PHST- 2020/04/14 06:00 [medline] PHST- 2018/10/05 06:00 [entrez] AID - 10.1002/jcph.1300 [doi] PST - ppublish SO - J Clin Pharmacol. 2019 Jan;59(1):107-111. doi: 10.1002/jcph.1300. Epub 2018 Oct 4. PMID- 34770403 OWN - NLM STAT- MEDLINE DCOM- 20211116 LR - 20211118 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 21 DP - 2021 Oct 26 TI - The Vulnerability of the Power Grid Structure: A System Analysis Based on Complex Network Theory. LID - 10.3390/s21217097 [doi] LID - 7097 AB - The safety and reliability of the power grid are related to national power security, economic development and people's daily life. The occurrence of extreme weather changes the external environment greatly. Including generators and transmission lines, many power grid units cannot resist such a huge attack and get damaged easily, which forces units to quit from the power grid running system for a while. Furthermore, if the number of influenced units is high enough, the whole power system will be destroyed by cascading failure caused by extreme weather. Aiming at dealing with the cascading failure emergencies, this paper is trying to improve the traditional power structural vulnerability model so that it can be used to discuss extreme weather and propose a theoretical topological model to help scholars measure the damage caused by extreme cases. Based on previous research in this field, this paper utilizes complex network knowledge to build the power grid topology model. Then, considering extreme cases and the three attack modes simulation process, this paper makes use of the characteristic parameters of the power grid topology model and designs an algorithm, according to the realistic situation of the propagation mechanism of cascading failure of the power grid model as well as extreme weather research. Finally, taking IEEE-30 and IEEE-118 node bus system as examples, which shows that the structural vulnerability method proposed in this paper can properly address the mechanism of unbalanced load of cascading failure of power grid units under extreme conditions and can provide theoretical reference for preventing and reducing the impact of extreme cases on power grid which improves the reliability of the power grid. FAU - Xie, Banghua AU - Xie B AD - Faculty of Engineering, China University of Geosciences, Wuhan 430074, China. FAU - Tian, Xiaoge AU - Tian X AD - Faculty of Engineering, China University of Geosciences, Wuhan 430074, China. FAU - Kong, Liulin AU - Kong L AD - Faculty of Engineering, China University of Geosciences, Wuhan 430074, China. FAU - Chen, Weiming AU - Chen W AUID- ORCID: 0000-0002-2660-5492 AD - Faculty of Engineering, China University of Geosciences, Wuhan 430074, China. LA - eng PT - Journal Article DEP - 20211026 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Algorithms MH - Computer Simulation MH - Humans MH - *Models, Theoretical MH - Reproducibility of Results MH - Systems Analysis PMC - PMC8587080 OTO - NOTNLM OT - attack modes OT - cascading failure OT - complex network OT - extreme weather OT - structural vulnerability COIS- The authors declare no conflict of interest. EDAT- 2021/11/14 06:00 MHDA- 2021/11/17 06:00 PMCR- 2021/10/26 CRDT- 2021/11/13 01:10 PHST- 2021/09/30 00:00 [received] PHST- 2021/10/19 00:00 [revised] PHST- 2021/10/22 00:00 [accepted] PHST- 2021/11/13 01:10 [entrez] PHST- 2021/11/14 06:00 [pubmed] PHST- 2021/11/17 06:00 [medline] PHST- 2021/10/26 00:00 [pmc-release] AID - s21217097 [pii] AID - sensors-21-07097 [pii] AID - 10.3390/s21217097 [doi] PST - epublish SO - Sensors (Basel). 2021 Oct 26;21(21):7097. doi: 10.3390/s21217097. PMID- 38676073 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240429 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 8 DP - 2024 Apr 11 TI - Prediction of Degraded Infrastructure Conditions for Railway Operation. LID - 10.3390/s24082456 [doi] LID - 2456 AB - In the railway sector, rolling stock and infrastructure must be maintained in perfect condition to ensure reliable and safe operation for passengers. Climate change is affecting the urban and regional infrastructure through sea level rise, water accumulations, river flooding, and other increased-frequency extreme natural situations (heavy rains or snows) which pose a challenge to maintenance. In this paper, the use of artificial intelligence based on predictive maintenance implementation is proposed for the early detection of degraded conditions of a bridge due to extreme climatic conditions. For this prediction, continuous monitoring is proposed, with the aim of establishing alarm thresholds to detect dangerous situations, so restrictions could be determined to mitigate the risk. However, one of the main challenges for railway infrastructure managers nowadays is the high cost of monitoring large infrastructures. In this work, a methodology for monitoring railway infrastructures to define the optimal number of transductors that are economically viable and the thresholds according to which infrastructure managers can make decisions concerning traffic safety is proposed. The methodology consists of three phases that use the application of machine learning (Random Forest) and artificial cognitive systems (LSTM recurrent neural networks). FAU - Sanz Bobi, Juan de Dios AU - Sanz Bobi JD AUID- ORCID: 0000-0002-8039-8527 AD - Department of Mechanical Engineering, Universidad Politécnica de Madrid-UPM, 28006 Madrid, Spain. FAU - Garrido Martínez-Llop, Pablo AU - Garrido Martínez-Llop P AUID- ORCID: 0000-0002-4851-1737 AD - Department of Applied Mathematics in Industrial Engineering, Universidad Politécnica de Madrid-UPM, 28006 Madrid, Spain. FAU - Rubio Marcos, Pablo AU - Rubio Marcos P AUID- ORCID: 0000-0001-9983-6358 AD - Universidad Politécnica de Madrid-UPM, 28006 Madrid, Spain. FAU - Solano Jiménez, Álvaro AU - Solano Jiménez Á AD - Universidad Politécnica de Madrid-UPM, 28006 Madrid, Spain. FAU - Fernández, Javier Gómez AU - Fernández JG AD - Department of Mechanical Engineering, Universidad Politécnica de Madrid-UPM, 28006 Madrid, Spain. LA - eng PT - Journal Article DEP - 20240411 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC11054954 OTO - NOTNLM OT - flood risk management OT - machine learning OT - predictive maintenance OT - railway dynamics OT - railway safety COIS- The authors declare no conflict of interest. EDAT- 2024/04/27 09:57 MHDA- 2024/04/27 09:58 PMCR- 2024/04/11 CRDT- 2024/04/27 01:26 PHST- 2024/02/15 00:00 [received] PHST- 2024/03/15 00:00 [revised] PHST- 2024/04/01 00:00 [accepted] PHST- 2024/04/27 09:58 [medline] PHST- 2024/04/27 09:57 [pubmed] PHST- 2024/04/27 01:26 [entrez] PHST- 2024/04/11 00:00 [pmc-release] AID - s24082456 [pii] AID - sensors-24-02456 [pii] AID - 10.3390/s24082456 [doi] PST - epublish SO - Sensors (Basel). 2024 Apr 11;24(8):2456. doi: 10.3390/s24082456. PMID- 36754715 OWN - NLM STAT- MEDLINE DCOM- 20231222 LR - 20241230 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 263 DP - 2024 Jan TI - Brain evolution and the meaning of catatonia - An update. PG - 139-150 LID - S0920-9964(23)00038-5 [pii] LID - 10.1016/j.schres.2023.01.026 [doi] AB - Back in 2004, in a chapter titled "Brain Evolution and the Meaning of Catatonia", a case was made that the syndrome's core meaning is embedded in millions of years of vertebrate brain evolution. (Fricchione, 2004) In this update, advances over the last almost 20 years, in catatonia theory and research in particular, and pertinent neuropsychiatry in general, will be applied to this question of meaning. The approach will rely heavily on a number of thought leaders, including Nicos Tinbergen, Paul MacLean, John Bowlby, M. Marsel Mesulam, Bruce McEwen and Karl Friston. Their guidance will be supplemented with a selected survey of 21(sty) century neuropsychiatry, neurophysiology, molecular biology, neuroimaging and neurotherapeutics as applied to the catatonic syndrome. In an attempt to address the question of the meaning of the catatonic syndrome in human life, we will employ two conceptual networks representing the intersubjectivity of the quantitative conceptual network of physical terms and the subjectivity of the qualitative conceptual network of mental and spiritual terms. In the process, a common referent providing extensional identity may emerge (Goodman, 1991). The goal of this exercise is to enhance our attunement with the experience of patients suffering with catatonia. A deeper understanding of catatonia's origins in brain evolution and of the challenges of individual epigenetic development in the setting of environmental events coupled with appreciation of what has been described as the most painful mammalian condition, that of separation, has the potential to foster greater efforts on the part of clinicians to diagnose and treat patients who present with catatonia. In addition, in this ancient and extreme tactic, evolved to provide safety from extreme survival threat, one can speculate what is at the core of human fear and the challenge it presents to all of us. And when the biology, psychology and sociology of catatonia are examined, the nature of solutions to the challenge may emerge. CI - Copyright © 2023 Elsevier B.V. All rights reserved. FAU - Fricchione, Gregory AU - Fricchione G AD - Benson-Henry Institute for Mind Body Medicine Division of Psychiatry and Medicine Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: gfricchione@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20230207 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Humans MH - *Catatonia/diagnosis MH - *Population Health MH - Brain/diagnostic imaging MH - Syndrome MH - Fear OTO - NOTNLM OT - Attachment OT - Catatonia OT - Meaning OT - Neuro-evolution OT - Separation OT - Stress COIS- Conflict of interest Royalties from APA Book: Catatonia. From Psychopathology to Neurobiology Revival Therapeutics: Consultant to new company planning to do catatonia research. EDAT- 2023/02/09 06:00 MHDA- 2023/12/22 06:43 CRDT- 2023/02/08 22:01 PHST- 2022/10/31 00:00 [received] PHST- 2023/01/16 00:00 [revised] PHST- 2023/01/18 00:00 [accepted] PHST- 2023/12/22 06:43 [medline] PHST- 2023/02/09 06:00 [pubmed] PHST- 2023/02/08 22:01 [entrez] AID - S0920-9964(23)00038-5 [pii] AID - 10.1016/j.schres.2023.01.026 [doi] PST - ppublish SO - Schizophr Res. 2024 Jan;263:139-150. doi: 10.1016/j.schres.2023.01.026. Epub 2023 Feb 7. PMID- 18467808 OWN - NLM STAT- MEDLINE DCOM- 20080624 LR - 20080509 IS - 0032-5481 (Print) IS - 0032-5481 (Linking) VI - 120 IP - 1 DP - 2008 Apr TI - Management of dyslipidemia in patients after solid organ transplantation. PG - 43-9 LID - 10.3810/pgm.2008.04.1759 [doi] AB - The increase in organ transplantation has led to primary care physicians assuming a greater role in the provision of health care. Cardiovascular disease is the leading cause of mortality in transplant patients. The risk factors for cardiovascular disease do not differ from the nontransplant population, except that there is increased prevalence of these risk factors in the transplant population. Post-transplant hyperlipidemia is extremely prevalent, partly because of the underlying condition causing the need for transplantation and partly because of the side effects of immunosuppressant agents. Although there are no large, cardiovascular event outcome trials demonstrating a benefit for lipid-lowering therapy in the transplant population, there is robust literature supporting this treatment in the nontransplant population, and numerous smaller trials in transplant patients have demonstrated the safety and efficacy of lipid-lowering therapy. This article reviews the evidence and treatment options for currently available lipid-lowering therapy in solid-organ transplant patients. FAU - Tannock, Lisa R AU - Tannock LR AD - Veterans Affairs Medical Center, Division of Endocrinology and Molecular Medicine, University of Kentucky, Room 567 Wethington Building, 900 S. Limestone, Lexington, KY 40536-0200, USA. lisa.tannock@uky.edu FAU - Reynolds, L Raymond AU - Reynolds LR LA - eng PT - Journal Article PT - Review PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) SB - IM MH - Dyslipidemias/*drug therapy MH - Humans MH - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use MH - *Organ Transplantation MH - Postoperative Complications RF - 32 EDAT- 2008/05/10 09:00 MHDA- 2008/06/25 09:00 CRDT- 2008/05/10 09:00 PHST- 2008/05/10 09:00 [pubmed] PHST- 2008/06/25 09:00 [medline] PHST- 2008/05/10 09:00 [entrez] AID - 10.3810/pgm.2008.04.1759 [doi] PST - ppublish SO - Postgrad Med. 2008 Apr;120(1):43-9. doi: 10.3810/pgm.2008.04.1759. PMID- 29330089 OWN - NLM STAT- MEDLINE DCOM- 20180706 LR - 20181202 IS - 1872-8308 (Electronic) IS - 0376-6357 (Linking) VI - 148 DP - 2018 Mar TI - Grouping promotes risk-taking in unfamiliar settings. PG - 41-45 LID - S0376-6357(17)30295-4 [pii] LID - 10.1016/j.beproc.2018.01.003 [doi] AB - Acting collectively in a group provides risk-reducing benefits. Yet individuals differ in how they take risks, with some being more willing than others to approach dangerous or unfamiliar settings. Therefore, individuals may need to adjust their behaviour when in groups, either as a result of perceiving greater safety or to coordinate collective responses, the latter of which may rely on within-group dynamics biased by group composition. In zebrafish we explored how these aspects of grouping affect risk-taking behaviour by comparing solitary to group conditions and testing the ability of group-member solitary responses to predict collective responses. We focused on approach-latency towards a novel object and an unusual food to test this, for shoals of five fish. There was no indication that collective latencies are predicted by how each fish responded when alone in terms of the extremes, the variance or the mean of group-member latency towards the unusual food and the novel-object. However, fish were overall faster and less variable in their approach when shoaling. This indicates lower risk aversion by individuals in groups, presumably as a result of group safety. An interesting consequence of the overall low risk-aversion in shoals is that more risk-aversive fish adjust their behaviour more than less risk averse fish. CI - Copyright © 2018 Elsevier B.V. All rights reserved. FAU - Kareklas, Kyriacos AU - Kareklas K AD - School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK. Electronic address: kkareklas01@qub.ac.uk. FAU - Elwood, Robert W AU - Elwood RW AD - School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK. FAU - Holland, Richard A AU - Holland RA AD - School of Biological Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK. LA - eng PT - Journal Article DEP - 20180109 PL - Netherlands TA - Behav Processes JT - Behavioural processes JID - 7703854 SB - IM MH - Animals MH - Behavior, Animal/*physiology MH - Environment MH - *Risk-Taking MH - *Social Behavior MH - Time Factors MH - Zebrafish/*physiology OTO - NOTNLM OT - Collective behaviour OT - Risk-taking OT - Shoal OT - Social facilitation OT - Zebrafish EDAT- 2018/01/14 06:00 MHDA- 2018/07/07 06:00 CRDT- 2018/01/14 06:00 PHST- 2017/06/23 00:00 [received] PHST- 2017/10/20 00:00 [revised] PHST- 2018/01/06 00:00 [accepted] PHST- 2018/01/14 06:00 [pubmed] PHST- 2018/07/07 06:00 [medline] PHST- 2018/01/14 06:00 [entrez] AID - S0376-6357(17)30295-4 [pii] AID - 10.1016/j.beproc.2018.01.003 [doi] PST - ppublish SO - Behav Processes. 2018 Mar;148:41-45. doi: 10.1016/j.beproc.2018.01.003. Epub 2018 Jan 9. PMID- 34694948 OWN - NLM STAT- MEDLINE DCOM- 20220510 LR - 20220726 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) VI - 25 IP - 3 DP - 2022 Jun TI - Use of a vaginal CO(2) laser for the management of genitourinary syndrome of menopause in gynecological cancer survivors: a systematic review. PG - 228-234 LID - 10.1080/13697137.2021.1990258 [doi] AB - Genitourinary syndrome of menopause (GSM) may arise from the hypoestrogenism caused by ovarian function destruction following gynecological cancer treatments. GSM may also be present in menopausal women and its symptoms might be exacerbated by cancer treatments. Historically, patients with hormone-dependent gynecological cancer and physicians have been less comfortable using vaginal estrogen due to fear of recurrence. CO(2) vaginal laser therapies have demonstrated efficacy as a non-hormonal alternative for GSM treatment in healthy menopausal patients. The objective of this study was to evaluate the data on the effect of a CO(2) vaginal laser for the management of GSM in gynecological cancer patients. Databases searched included MEDLINE, Embase, PubMed, Cochrane and Google Scholar. Selected studies assessed use of a CO(2) vaginal laser in gynecological cancer patients with GSM. A total of 269 studies were retrieved. Four studies met the inclusion criteria. Each study followed a different type of CO(2) vaginal laser protocol for the management of GSM in gynecological cancer patients. There are no randomized controlled trials that assess the use of a CO(2) vaginal laser in gynecologic cancer patients. The number of published gynecological cancer patients treated with a CO(2) laser for the management of GSM is extremely limited (N < 100). There is a lack of literature on the impact and safety of vaginal CO(2) laser use to manage GSM in gynecologic cancer patients. FAU - Mejia-Gomez, J AU - Mejia-Gomez J AUID- ORCID: 0000-0001-6943-8922 AD - Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. FAU - Bouteaud, J AU - Bouteaud J AD - Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. FAU - Philippopoulos, E AU - Philippopoulos E AUID- ORCID: 0000-0002-7189-6161 AD - Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. FAU - Wolfman, W AU - Wolfman W AUID- ORCID: 0000-0001-8996-7303 AD - Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. FAU - Brezden-Masley, C AU - Brezden-Masley C AD - Department of Medical Oncology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Systematic Review DEP - 20211025 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 RN - 142M471B3J (Carbon Dioxide) SB - IM MH - *Cancer Survivors MH - Carbon Dioxide MH - Female MH - Humans MH - *Laser Therapy/methods MH - *Lasers, Gas/therapeutic use MH - Menopause MH - *Neoplasms MH - Syndrome MH - Vagina/surgery OTO - NOTNLM OT - CO2 vaginal laser OT - genitourinary syndrome of menopause OT - gynecological cancer EDAT- 2021/10/26 06:00 MHDA- 2022/05/11 06:00 CRDT- 2021/10/25 17:15 PHST- 2021/10/26 06:00 [pubmed] PHST- 2022/05/11 06:00 [medline] PHST- 2021/10/25 17:15 [entrez] AID - 10.1080/13697137.2021.1990258 [doi] PST - ppublish SO - Climacteric. 2022 Jun;25(3):228-234. doi: 10.1080/13697137.2021.1990258. Epub 2021 Oct 25. PMID- 25841161 OWN - NLM STAT- MEDLINE DCOM- 20151216 LR - 20181202 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 79 DP - 2015 Jun TI - Impact of real-time traffic characteristics on freeway crash occurrence: systematic review and meta-analysis. PG - 198-211 LID - S0001-4575(15)00087-1 [pii] LID - 10.1016/j.aap.2015.03.013 [doi] AB - The development of methods for real-time crash prediction as a function of current or recent traffic and roadway conditions is gaining increasing attention in the literature. Numerous studies have modeled the relationships between traffic characteristics and crash occurrence, and significant progress has been made. Given the accumulated evidence on this topic and the lack of an articulate summary of research status, challenges, and opportunities, there is an urgent need to scientifically review these studies and to synthesize the existing state-of-the-art knowledge. This paper addresses this need by undertaking a systematic literature review to identify current knowledge, challenges, and opportunities, and then conducts a meta-analysis of existing studies to provide a summary impact of traffic characteristics on crash occurrence. Sensitivity analyses were conducted to assess quality, publication bias, and outlier bias of the various studies; and the time intervals used to measure traffic characteristics were also considered. As a result of this comprehensive and systematic review, issues in study designs, traffic and crash data, and model development and validation are discussed. Outcomes of this study are intended to provide researchers focused on real-time crash prediction with greater insight into the modeling of this important but extremely challenging safety issue. CI - Copyright © 2015 Elsevier Ltd. All rights reserved. FAU - Roshandel, Saman AU - Roshandel S AD - Civil Engineering & Built Environment School, Queensland University of Technology, 2 George St., GPO Box 2434, Brisbane, QLD 4001, Australia. Electronic address: saman.roshandel@student.qut.edu.au. FAU - Zheng, Zuduo AU - Zheng Z AD - Civil Engineering & Built Environment School, Queensland University of Technology, 2 George St., GPO Box 2434, Brisbane, QLD 4001, Australia. Electronic address: zuduo.zheng@qut.edu.au. FAU - Washington, Simon AU - Washington S AD - Civil Engineering & Built Environment School, Queensland University of Technology, 2 George St., GPO Box 2434, Brisbane, QLD 4001, Australia. Electronic address: simon.washington@qut.edu.au. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20150402 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*statistics & numerical data/*trends MH - Automobile Driving/*statistics & numerical data MH - Forecasting MH - Humans MH - Models, Theoretical MH - Risk Assessment/*methods MH - Safety/*statistics & numerical data OTO - NOTNLM OT - Crash prediction OT - Meta-analysis OT - Road safety OT - Systematic review OT - Traffic characteristics EDAT- 2015/04/05 06:00 MHDA- 2015/12/19 06:00 CRDT- 2015/04/05 06:00 PHST- 2014/08/08 00:00 [received] PHST- 2015/01/30 00:00 [revised] PHST- 2015/03/10 00:00 [accepted] PHST- 2015/04/05 06:00 [entrez] PHST- 2015/04/05 06:00 [pubmed] PHST- 2015/12/19 06:00 [medline] AID - S0001-4575(15)00087-1 [pii] AID - 10.1016/j.aap.2015.03.013 [doi] PST - ppublish SO - Accid Anal Prev. 2015 Jun;79:198-211. doi: 10.1016/j.aap.2015.03.013. Epub 2015 Apr 2. PMID- 30272782 OWN - NLM STAT- MEDLINE DCOM- 20190530 LR - 20190530 IS - 0047-2425 (Print) IS - 0047-2425 (Linking) VI - 47 IP - 5 DP - 2018 Sep TI - Effect of Rainfall on the Microbial Water Quality of a Tropical Urban Catchment. PG - 1242-1248 LID - 10.2134/jeq2018.03.0099 [doi] AB - Wet weather conditions have been associated with increased bacterial and viral counts in surface waters. Moreover, heavy rainfall and flooding were found to be the most common events preceding waterborne disease outbreaks associated with extreme weather conditions. This study aimed to examine the effect of rainfall on the quality of surface waters and to determine its suitability for primary contact recreation during wet weather conditions. A total of 228 catchment water samples were collected during wet and dry periods. Parameters that were found to increase with increasing rainfall were , enterococci, somatic coliphages, and turbidity, whereas total dissolved solids were found to decrease. Positive correlations ( < 0.05) were observed between cumulative rainfall and geometric mean concentrations of , enterococci, somatic coliphages, and turbidity ( = 0.69-0.95), whereas a negative correlation was observed between cumulative rainfall and total dissolved solids ( = -0.58). In addition, a rapid decline in water quality was observed during heavy rainfall that resulted in failure to meet recreational water quality guidelines. In view of public health and safety, primary recreational activities in the water catchment may not be advisable during or immediately after a rainfall event due to poor water quality. CI - Copyright © by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America, Inc. FAU - Fang, Haoming AU - Fang H FAU - Vergara, Genevieve Gabrielle Rose AU - Vergara GGR FAU - Goh, Shin Giek AU - Goh SG FAU - Ang, Cassandra Yu Lin AU - Ang CYL FAU - Gu, Xiaoqiong AU - Gu X FAU - Gin, Karina Yew-Hoong AU - Gin KY LA - eng PT - Journal Article PL - United States TA - J Environ Qual JT - Journal of environmental quality JID - 0330666 SB - IM MH - Enterococcus MH - *Environmental Monitoring MH - Floods MH - Rain MH - Tropical Climate MH - *Water Microbiology MH - Water Quality EDAT- 2018/10/03 06:00 MHDA- 2019/05/31 06:00 CRDT- 2018/10/02 06:00 PHST- 2018/10/02 06:00 [entrez] PHST- 2018/10/03 06:00 [pubmed] PHST- 2019/05/31 06:00 [medline] AID - 10.2134/jeq2018.03.0099 [doi] PST - ppublish SO - J Environ Qual. 2018 Sep;47(5):1242-1248. doi: 10.2134/jeq2018.03.0099. PMID- 26239966 OWN - NLM STAT- MEDLINE DCOM- 20160816 LR - 20151102 IS - 1769-7123 (Electronic) IS - 0923-2508 (Linking) VI - 166 IP - 9 DP - 2015 Nov TI - Genome expression of Thermococcus barophilus and Thermococcus kodakarensis in response to different hydrostatic pressure conditions. PG - 717-25 LID - S0923-2508(15)00122-9 [pii] LID - 10.1016/j.resmic.2015.07.006 [doi] AB - Transcriptomes were analyzed for two related hyperthermophilic archaeal species, the piezophilic Thermococcus barophilus strain MP and piezosensitive Thermococcus kodakarensis strain KOD1 subjected to high hydrostatic pressures. A total of 378 genes were differentially expressed in T. barophilus cells grown at 0.1, 40 and 70 MPa, whereas 141 genes were differentially regulated in T. kodakarensis cells grown at 0.1 and 25 MPa. In T. barophilus cells grown under stress conditions (0.1 and 70 MPa), 178 upregulated genes were distributed among three clusters of orthologous groups (COG): energy production and conversion (C), inorganic ion transport and metabolism (P) and carbohydrate transport and metabolism (G), whereas 156 downregulated genes were distributed among: amino acid transport and metabolism (E), replication, recombination and repair (L) and nucleotide transport and metabolism (F). The expression of 141 genes was regulated in T. kodakarensis cells grown under stress conditions (25 MPa); 71 downregulated genes belong to three COG: energy production and conversion (C), amino acid transport and metabolism (E) and transcription (K), whereas 70 upregulated genes are associated with replication, recombination and repair (L), coenzyme transport (H) and defense mechanisms (V). CI - Copyright © 2015 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. FAU - Vannier, Pauline AU - Vannier P AD - Matís ohf., Food Safety, Environment and Genetics, Vinlandsleið 12, 113 Reykjavik, Iceland; Université de Bretagne Occidentale, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; CNRS, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; Ifremer, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Technopôle Brest-Iroise, BP70, 29 280 Plouzané, France. FAU - Michoud, Grégoire AU - Michoud G AD - Université de Bretagne Occidentale, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; CNRS, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; Ifremer, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Technopôle Brest-Iroise, BP70, 29 280 Plouzané, France. FAU - Oger, Philippe AU - Oger P AD - Laboratoire de Géologie de Lyon, UMR 5276 CNRS, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon, Lyon, France. FAU - Marteinsson, Viggó Þór AU - Marteinsson VÞ AD - Matís ohf., Food Safety, Environment and Genetics, Vinlandsleið 12, 113 Reykjavik, Iceland; Agricultural University of Iceland, Hvanneyri, 311 Borgarnes, Iceland. Electronic address: viggo.th.marteinsson@matis.is. FAU - Jebbar, Mohamed AU - Jebbar M AD - Université de Bretagne Occidentale, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; CNRS, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Institut Universitaire Européen de la Mer (IUEM), rue Dumont d'Urville, 29 280 Plouzané, France; Ifremer, UMR 6197-Laboratoire de Microbiologie des Environnements Extrêmes (LM2E), Technopôle Brest-Iroise, BP70, 29 280 Plouzané, France. Electronic address: mohamed.jebbar@univ-brest.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150801 PL - France TA - Res Microbiol JT - Research in microbiology JID - 8907468 RN - 0 (Amino Acids) SB - IM MH - Amino Acids/genetics/metabolism MH - DNA Replication MH - *Gene Expression Profiling MH - Genome, Archaeal MH - *Hydrostatic Pressure MH - Stress, Physiological/*genetics MH - Thermococcus/*genetics/growth & development/metabolism OTO - NOTNLM OT - Archaea OT - HHP responsive genes OT - Hyperthermophilic OT - Piezophily OT - Transcriptomic EDAT- 2015/08/05 06:00 MHDA- 2016/08/17 06:00 CRDT- 2015/08/05 06:00 PHST- 2015/03/16 00:00 [received] PHST- 2015/07/15 00:00 [revised] PHST- 2015/07/17 00:00 [accepted] PHST- 2015/08/05 06:00 [entrez] PHST- 2015/08/05 06:00 [pubmed] PHST- 2016/08/17 06:00 [medline] AID - S0923-2508(15)00122-9 [pii] AID - 10.1016/j.resmic.2015.07.006 [doi] PST - ppublish SO - Res Microbiol. 2015 Nov;166(9):717-25. doi: 10.1016/j.resmic.2015.07.006. Epub 2015 Aug 1. PMID- 8642113 OWN - NLM STAT- MEDLINE DCOM- 19960715 LR - 20190515 IS - 0001-4966 (Print) IS - 0001-4966 (Linking) VI - 99 IP - 5 DP - 1996 May TI - Acoustically enhanced bubble growth at low frequencies and its implications for human diver and marine mammal safety. PG - 2898-907 AB - Computations are made of the conditions necessary to obtain bubble growth by rectified diffusion under a variety of conditions associated with low-frequency sonar propagation in the ocean. The complex issue of microbubble nuclei stabilization is treated by assuming either a sufficient level of supersaturation to stabilize the initial bubble size, or by examining a microbubble nucleus with zero surface tension. The bubble growth rates and thresholds are obtained for a ranged of sound-pressure levels (re: 1 microPa) from 150-220 dB, for initial bubble radii from 1-10 microns, and for levels of the dissolved gas concentration from 100% to 223% of saturation. It was determined that for the range of conditions examined, it was necessary to utilize three different formulations of the equations for bubble growth. The results of these calculations (and assumptions concerning nuclei stabilization) indicate that for SPL's in excess of 210 dB, significant bubble growth can be expected to occur, and divers and marine mammals exposed to these conditions could be at risk. For SPL's below about 190 dB, however, except under relatively extreme conditions of supersaturation, significant bubble growth is unexpected. FAU - Crum, L A AU - Crum LA AD - Applied Physics Laboratory, University of Washington, Seattle 98105, USA. FAU - Mao, Y AU - Mao Y LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - J Acoust Soc Am JT - The Journal of the Acoustical Society of America JID - 7503051 SB - IM MH - *Acoustics MH - Decompression Sickness MH - *Diving MH - Humans MH - Models, Theoretical MH - Oceans and Seas MH - *Safety EDAT- 1996/05/01 00:00 MHDA- 1996/05/01 00:01 CRDT- 1996/05/01 00:00 PHST- 1996/05/01 00:00 [pubmed] PHST- 1996/05/01 00:01 [medline] PHST- 1996/05/01 00:00 [entrez] AID - 10.1121/1.414859 [doi] PST - ppublish SO - J Acoust Soc Am. 1996 May;99(5):2898-907. doi: 10.1121/1.414859. PMID- 38364642 OWN - NLM STAT- MEDLINE DCOM- 20240311 LR - 20240311 IS - 1879-3363 (Electronic) IS - 0025-326X (Linking) VI - 200 DP - 2024 Mar TI - Tolerance and behavioral responses of crabs in disturbed mangroves during a heatwave event. PG - 116165 LID - S0025-326X(24)00142-5 [pii] LID - 10.1016/j.marpolbul.2024.116165 [doi] AB - We assessed the tolerance, safety margins, and behavioral responses to extreme conditions of the mangrove fiddler crab Leptuca speciosa during a heatwave event (May of 2022), in the Yucatán Peninsula, Mexico. In the field, L. speciosa demonstrated aggregation behavior, congregating in areas that were above the water level to escape the extreme water conditions. In the laboratory, we determined that the upper critical thermal limits (UT(99)) ranged from 40.2 °C and 42 °C. For salinity, the lethal concentration was LC(99) = 39 psu. Our study showed that L. speciosa, one of the most conspicuous and resilient inhabitants of mangroves, had no safety margin and low tolerance to the climatic conditions as measured in the heatwave, and displayed a protective behavior. Considering that the frequency and intensity of heatwaves have been predicted to increase in the next few years, the combined multiple stressors effect may increase the vulnerability of mangrove organisms. CI - Copyright © 2024 Elsevier Ltd. All rights reserved. FAU - Capparelli, Mariana V AU - Capparelli MV AD - Estación El Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km 9.5, 24157 Ciudad del Carmen, Mexico. FAU - Pérez-Ceballos, Rosela AU - Pérez-Ceballos R AD - Estación El Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km 9.5, 24157 Ciudad del Carmen, Mexico; Consejo Nacional de Humanidades de Ciencias y Tecnologías (CONAHCYT), Mexico. FAU - Suárez-Mozo, Nancy Yolimar AU - Suárez-Mozo NY AD - Estación El Carmen, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Carretera Carmen-Puerto Real km 9.5, 24157 Ciudad del Carmen, Mexico. FAU - Moulatlet, Gabriel M AU - Moulatlet GM AD - The Arizona Institute for Resilience, University of Arizona, Tucson, AZ, USA; Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA. Electronic address: gmoulatlet@arizona.edu. LA - eng PT - Journal Article DEP - 20240216 PL - England TA - Mar Pollut Bull JT - Marine pollution bulletin JID - 0260231 RN - 059QF0KO0R (Water) SB - IM MH - Animals MH - *Brachyura MH - Salinity MH - Water MH - Mexico OTO - NOTNLM OT - Climate change OT - Fiddler crabs OT - Gulf of Mexico OT - Multi stressors OT - Salinization COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/02/17 10:43 MHDA- 2024/03/11 06:42 CRDT- 2024/02/16 18:13 PHST- 2023/11/13 00:00 [received] PHST- 2024/02/09 00:00 [revised] PHST- 2024/02/12 00:00 [accepted] PHST- 2024/03/11 06:42 [medline] PHST- 2024/02/17 10:43 [pubmed] PHST- 2024/02/16 18:13 [entrez] AID - S0025-326X(24)00142-5 [pii] AID - 10.1016/j.marpolbul.2024.116165 [doi] PST - ppublish SO - Mar Pollut Bull. 2024 Mar;200:116165. doi: 10.1016/j.marpolbul.2024.116165. Epub 2024 Feb 16. PMID- 22315419 OWN - NLM STAT- MEDLINE DCOM- 20120521 LR - 20240315 IS - 1091-6490 (Electronic) IS - 0027-8424 (Print) IS - 0027-8424 (Linking) VI - 109 IP - 13 DP - 2012 Mar 27 TI - Insights from past millennia into climatic impacts on human health and survival. PG - 4730-7 LID - 10.1073/pnas.1120177109 [doi] AB - Climate change poses threats to human health, safety, and survival via weather extremes and climatic impacts on food yields, fresh water, infectious diseases, conflict, and displacement. Paradoxically, these risks to health are neither widely nor fully recognized. Historical experiences of diverse societies experiencing climatic changes, spanning multicentury to single-year duration, provide insights into population health vulnerability--even though most climatic changes were considerably less than those anticipated this century and beyond. Historical experience indicates the following. (i) Long-term climate changes have often destabilized civilizations, typically via food shortages, consequent hunger, disease, and unrest. (ii) Medium-term climatic adversity has frequently caused similar health, social, and sometimes political consequences. (iii) Infectious disease epidemics have often occurred in association with briefer episodes of temperature shifts, food shortages, impoverishment, and social disruption. (iv) Societies have often learnt to cope (despite hardship for some groups) with recurring shorter-term (decadal to multiyear) regional climatic cycles (e.g., El Niño Southern Oscillation)--except when extreme phases occur. (v) The drought-famine-starvation nexus has been the main, recurring, serious threat to health. Warming this century is not only likely to greatly exceed the Holocene's natural multidecadal temperature fluctuations but to occur faster. Along with greater climatic variability, models project an increased geographic range and severity of droughts. Modern societies, although larger, better resourced, and more interconnected than past societies, are less flexible, more infrastructure-dependent, densely populated, and hence are vulnerable. Adverse historical climate-related health experiences underscore the case for abating human-induced climate change. FAU - McMichael, Anthony J AU - McMichael AJ AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra ACT 0200, Australia. tony.mcmichael@anu.edu.au LA - eng PT - Historical Article PT - Journal Article PT - Review DEP - 20120206 PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 SB - IM MH - Climate Change/*history MH - Geography MH - *Health MH - History, Ancient MH - Humans MH - Risk Factors MH - Survival Analysis MH - Time Factors PMC - PMC3324023 COIS- The author declares no conflict of interest. EDAT- 2012/02/09 06:00 MHDA- 2012/05/23 06:00 PMCR- 2012/02/06 CRDT- 2012/02/09 06:00 PHST- 2012/02/09 06:00 [entrez] PHST- 2012/02/09 06:00 [pubmed] PHST- 2012/05/23 06:00 [medline] PHST- 2012/02/06 00:00 [pmc-release] AID - 1120177109 [pii] AID - 201120177 [pii] AID - 10.1073/pnas.1120177109 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4730-7. doi: 10.1073/pnas.1120177109. Epub 2012 Feb 6. PMID- 37544041 OWN - NLM STAT- MEDLINE DCOM- 20230919 LR - 20230919 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 192 DP - 2023 Nov TI - The impact of different service states of tunnel lighting on traffic safety. PG - 107237 LID - S0001-4575(23)00284-1 [pii] LID - 10.1016/j.aap.2023.107237 [doi] AB - The service states of tunnel lighting will directly affect the lighting conditions, which affect traffic safety. Therefore, it is imperative to evaluate and predict traffic safety accurately in different lighting states. In this research, three hundred experimental scenarios of the service states of tunnel lighting were designed and implemented to evaluate the impact of different service states of tunnel lighting on traffic safety. The evaluation was achieved through a visual identification experiment in a physical tunnel. The experimental results show higher simulated vehicle speeds pose a greater threat to traffic safety. The severity of lighting attenuation contributes to an increased risk to traffic safety. An increase in the number of luminaires failure also poses a greater threat to traffic safety. The newly proposed traffic safety factor was employed to evaluate traffic safety quantitatively in road tunnels. To improve the accuracy and comprehensiveness of the traffic safety factor prediction in different lighting service states, an advanced neural network prediction system was developed. The prediction system was constructed using the Sparrow Search Algorithm (SSA) to optimize Extreme Learning Machine (ELM) neural network, and the dataset from the experiment was used for the prediction model. The SSA-ELM neural network model is a reliable model that can predict the traffic safety factor comprehensively and accurately. The recommended threshold value for the traffic safety factor is 0.6. When the value falls below 0.6, it shows that the service states of tunnel lighting pose a threat to traffic safety in the tunnel. These findings can provide insights into the safe and energy-efficient maintenance of road tunnels. CI - Copyright © 2023 Elsevier Ltd. All rights reserved. FAU - Wang, Xiaoxia AU - Wang X AD - Guangdong University of Technology School of Civil and Transportation Engineering, Guangzhou 511400, PR China. FAU - You, Linhai AU - You L AD - Guangdong University of Technology School of Civil and Transportation Engineering, Guangzhou 511400, PR China. FAU - Chen, Jianzhong AU - Chen J AD - China Merchants Chongqing Communications Technology Research and Design Institute Co Ltd, Chongqing 400000, PR China. Electronic address: chenjianzhongcq@163.com. FAU - Han, Shuang AU - Han S AD - Guangdong University of Technology School of Civil and Transportation Engineering, Guangzhou 511400, PR China. LA - eng PT - Journal Article DEP - 20230804 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Humans MH - *Accidents, Traffic/prevention & control MH - *Lighting MH - Safety MH - Algorithms MH - Neural Networks, Computer OTO - NOTNLM OT - Lighting attenuation OT - Luminaire failure OT - SSA-ELM neural network OT - Traffic safety OT - Tunnel lighting COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/08/07 00:42 MHDA- 2023/09/19 06:42 CRDT- 2023/08/06 18:02 PHST- 2023/01/19 00:00 [received] PHST- 2023/05/17 00:00 [revised] PHST- 2023/07/26 00:00 [accepted] PHST- 2023/09/19 06:42 [medline] PHST- 2023/08/07 00:42 [pubmed] PHST- 2023/08/06 18:02 [entrez] AID - S0001-4575(23)00284-1 [pii] AID - 10.1016/j.aap.2023.107237 [doi] PST - ppublish SO - Accid Anal Prev. 2023 Nov;192:107237. doi: 10.1016/j.aap.2023.107237. Epub 2023 Aug 4. PMID- 11795423 OWN - NLM STAT- MEDLINE DCOM- 20020204 LR - 20190616 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 953 DP - 2001 Dec TI - Regulated gene expression in gene therapy. PG - 53-63 AB - The original model of gene therapy, that of efficient delivery, durable transfer, and stable expression of transgenes to correct a gene defect underlying an inherited disease, is limited in light of improved understanding of the processes involved. Techniques that enable regulated expression of transgenes may enhance safety and allow us to regulate the timing and level of expression with a goal of precisely targeting a therapeutic level between the extremes of suboptimal and supraoptimal thresholds. Using regulated systems to control protein expression has practical and possibly essential roles for the success of safe and effective gene therapy in a number of clinical situations. Pharmacologically regulated gene expression is an evolving tool, and no individual system may be effective in all clinical applications. FAU - Zoltick, P W AU - Zoltick PW AD - Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia 19104, USA. FAU - Wilson, J M AU - Wilson JM LA - eng PT - Journal Article PT - Review PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 0 (Ligands) SB - IM MH - Animals MH - Gene Expression Regulation/*genetics MH - Genetic Therapy/*methods MH - Humans MH - Ligands RF - 65 EDAT- 2002/01/25 10:00 MHDA- 2002/02/05 10:01 CRDT- 2002/01/25 10:00 PHST- 2002/01/25 10:00 [pubmed] PHST- 2002/02/05 10:01 [medline] PHST- 2002/01/25 10:00 [entrez] AID - 10.1111/j.1749-6632.2001.tb11360.x [doi] PST - ppublish SO - Ann N Y Acad Sci. 2001 Dec;953:53-63. doi: 10.1111/j.1749-6632.2001.tb11360.x. PMID- 17342004 OWN - NLM STAT- MEDLINE DCOM- 20070420 LR - 20191110 IS - 0889-7204 (Print) IS - 0889-7204 (Linking) VI - 22 IP - 1 DP - 2007 Winter TI - Current endovascular treatment of peripheral arterial disease. PG - 31-7 AB - Atherosclerotic peripheral arterial disease is a common medical problem worldwide and portends a poor prognosis because of increased cardiovascular morbidity and mortality. Regular exercise, weight loss, and aggressive risk factor modification, including treatment of dyslipidemia and complete cessation of smoking, is extremely important in this high-risk cohort. Vascular surgery in these patients, who often have concomitant coronary or cerebrovascular atherosclerosis, is associated with significant risk. Steady improvements in endovascular revascularization techniques have made this a safe and effective alternate revascularization modality. Percutaneous peripheral vascular interventions have increased dramatically in recent years, from 90,000 in 1994 to more than 200,000 in 1997, and endovascular techniques may soon replace up to 50% of traditional vascular operations. In this article, the authors review the current state of interventional treatment for peripheral arterial disease. FAU - Mardikar, H M AU - Mardikar HM AD - Spandan Heart Institute and Research Center, Nagpur, India. FAU - Mukherjee, Debabrata AU - Mukherjee D LA - eng PT - Journal Article PT - Review PL - United States TA - Prog Cardiovasc Nurs JT - Progress in cardiovascular nursing JID - 8704064 RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) RN - 0 (Platelet Aggregation Inhibitors) SB - IM MH - Acute Disease MH - Angioplasty/*methods/nursing/statistics & numerical data MH - Aortic Diseases/diagnosis/surgery MH - Combined Modality Therapy MH - Disease Progression MH - Exercise Therapy MH - Femoral Artery MH - Humans MH - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use MH - Iliac Artery MH - Leg/*blood supply MH - Nurse's Role MH - Patient Selection MH - Perioperative Care/methods/nursing MH - Peripheral Vascular Diseases/diagnosis/epidemiology/*therapy MH - Platelet Aggregation Inhibitors/therapeutic use MH - Popliteal Artery MH - Prognosis MH - Risk Factors MH - Risk Reduction Behavior MH - Safety MH - Stents MH - Treatment Outcome RF - 42 EDAT- 2007/03/08 09:00 MHDA- 2007/04/21 09:00 CRDT- 2007/03/08 09:00 PHST- 2007/03/08 09:00 [pubmed] PHST- 2007/04/21 09:00 [medline] PHST- 2007/03/08 09:00 [entrez] AID - 10.1111/j.0889-7204.2007.05596.x [doi] PST - ppublish SO - Prog Cardiovasc Nurs. 2007 Winter;22(1):31-7. doi: 10.1111/j.0889-7204.2007.05596.x. PMID- 39097015 OWN - NLM STAT- MEDLINE DCOM- 20240816 LR - 20240816 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 949 DP - 2024 Nov 1 TI - Mortality risk and burden of sudden cardiac arrest associated with hot nights, heatwaves, cold spells, and non-optimum temperatures in 0.88 million patients: An individual-level case-crossover study. PG - 175208 LID - S0048-9697(24)05358-0 [pii] LID - 10.1016/j.scitotenv.2024.175208 [doi] AB - Sudden cardiac arrest (SCA) is a global health concern, imposing a substantial mortality burden. However, the understanding of the impact of various extreme temperature events, when accounting for the effect of daily average temperature on SCA, remains incomplete. Additionally, the assessment of SCA mortality burden associated with temperatures from an individual-level design is limited. This nationwide case-crossover study collected individual SCA death records across all (2844) county-level administrative units in the Chinese Mainland from 2013 to 2019. Four definitions for hot nights and ten for both cold spells and heatwaves were established using various temperature thresholds and durations. Conditional logistic regression models combined with distributed lag nonlinear models were employed to estimate the cumulative exposure-response relationships. Based on 887,662 SCA decedents, this analysis found that both hot nights [odds ratio (OR): 1.28; attributable fraction (AF): 1.32 %] and heatwaves (OR: 1.40; AF: 1.29 %) exhibited significant added effects on SCA mortality independent of daily average temperatures, while cold spells were not associated with an elevated SCA risk after accounting for effects of temperatures. Cold temperatures [below the minimum mortality temperature (MMT)] accounted for a larger mortality burden than high temperatures (above the MMT) [AF: 12.2 % vs. 1.5 %]. Higher temperature-related mortality risks and burdens were observed in patients who experienced out-of-hospital cardiac arrest compared to those with in-hospital cardiac arrest. This nationwide study presents the most compelling and comprehensive evidence of the elevated mortality risk and burden of SCA associated with extreme temperature events and ambient temperatures amid global warming. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Wang, Lijun AU - Wang L AD - National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Liu, Jiangdong AU - Liu J AD - Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Yin, Peng AU - Yin P AD - National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Gao, Ya AU - Gao Y AD - Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Jiang, Yixuan AU - Jiang Y AD - Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Kan, Haidong AU - Kan H AD - Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Zhou, Maigeng AU - Zhou M AD - National Center for Chronic Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Ao, Hushan AU - Ao H AD - Department of Anesthesiology, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: aohushan@126.com. FAU - Chen, Renjie AU - Chen R AD - Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. Electronic address: chenrenjie@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20240806 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - Humans MH - *Death, Sudden, Cardiac/epidemiology MH - *Cross-Over Studies MH - China/epidemiology MH - *Cold Temperature/adverse effects MH - Hot Temperature/adverse effects MH - Middle Aged MH - Male MH - Female MH - Aged MH - Adult MH - Risk Factors OTO - NOTNLM OT - Ambient temperature OT - Cold spell OT - Heat wave OT - Hot night OT - Sudden cardiac arrest COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/08/04 13:44 MHDA- 2024/08/16 06:42 CRDT- 2024/08/03 19:19 PHST- 2024/04/12 00:00 [received] PHST- 2024/07/15 00:00 [revised] PHST- 2024/07/31 00:00 [accepted] PHST- 2024/08/16 06:42 [medline] PHST- 2024/08/04 13:44 [pubmed] PHST- 2024/08/03 19:19 [entrez] AID - S0048-9697(24)05358-0 [pii] AID - 10.1016/j.scitotenv.2024.175208 [doi] PST - ppublish SO - Sci Total Environ. 2024 Nov 1;949:175208. doi: 10.1016/j.scitotenv.2024.175208. Epub 2024 Aug 6. PMID- 29795046 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20180530 LR - 20230926 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 18 IP - 6 DP - 2018 May 24 TI - Spectral Kurtosis Entropy and Weighted SaE-ELM for Bogie Fault Diagnosis under Variable Conditions. LID - 10.3390/s18061705 [doi] LID - 1705 AB - Bogies are crucial for the safe operation of rail transit systems and usually work under uncertain and variable operating conditions. However, the diagnosis of bogie faults under variable conditions has barely been discussed until now. Thus, it is valuable to develop effective methods to deal with variable conditions. Besides, considering that the normal data for training are much more than the faulty data in practice, there is another problem in that only a small amount of data is available that includes faults. Concerning these issues, this paper proposes two new algorithms: (1) A novel feature parameter named spectral kurtosis entropy (SKE) is proposed based on the protrugram. The SKE not only avoids the manual post-processing of the protrugram but also has strong robustness to the operating conditions and parameter configurations, which have been validated by a simulation experiment in this paper. In this paper, the SKE, in conjunction with variational mode decomposition (VMD), is employed for feature extraction under variable conditions. (2) A new learning algorithm named weighted self-adaptive evolutionary extreme learning machine (WSaE-ELM) is proposed. WSaE-ELM gives each sample an extra sample weight to rebalance the training data and optimizes these weights along with the parameters of hidden neurons by means of the self-adaptive differential evolution algorithm. Finally, the hybrid method based on VMD, SKE, and WSaE-ELM is verified by using the vibration signals gathered from real bogies with speed variations. It is demonstrated that the proposed method of bogie fault diagnosis outperforms the conventional methods by up to 4.42% and 6.22%, respectively, in percentages of accuracy under variable conditions. FAU - Wang, Zhipeng AU - Wang Z AUID- ORCID: 0000-0003-3039-7582 AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. zpwang@bjtu.edu.cn. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. zpwang@bjtu.edu.cn. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. zpwang@bjtu.edu.cn. FAU - Jia, Limin AU - Jia L AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. lmjia@bjtu.edu.cn. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. lmjia@bjtu.edu.cn. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. lmjia@bjtu.edu.cn. FAU - Kou, Linlin AU - Kou L AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. 13114254@bjtu.edu.cn. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. 13114254@bjtu.edu.cn. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. 13114254@bjtu.edu.cn. FAU - Qin, Yong AU - Qin Y AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. yqin@bjtu.edu.cn. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. yqin@bjtu.edu.cn. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. yqin@bjtu.edu.cn. LA - eng PT - Journal Article DEP - 20180524 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 PMC - PMC6022050 OTO - NOTNLM OT - bogie fault diagnosis OT - protrugram OT - spectral kurtosis entropy OT - variational mode decomposition OT - weighted self-adaptive evolutionary extreme learning machine COIS- The authors declare no conflict of interest. EDAT- 2018/05/26 06:00 MHDA- 2018/05/26 06:01 PMCR- 2018/06/01 CRDT- 2018/05/26 06:00 PHST- 2018/04/24 00:00 [received] PHST- 2018/05/18 00:00 [revised] PHST- 2018/05/22 00:00 [accepted] PHST- 2018/05/26 06:00 [entrez] PHST- 2018/05/26 06:00 [pubmed] PHST- 2018/05/26 06:01 [medline] PHST- 2018/06/01 00:00 [pmc-release] AID - s18061705 [pii] AID - sensors-18-01705 [pii] AID - 10.3390/s18061705 [doi] PST - epublish SO - Sensors (Basel). 2018 May 24;18(6):1705. doi: 10.3390/s18061705. PMID- 28396988 OWN - NLM STAT- MEDLINE DCOM- 20180831 LR - 20181202 IS - 1861-0692 (Electronic) IS - 1861-0684 (Linking) VI - 106 IP - 8 DP - 2017 Aug TI - The non-vitamin K antagonist oral anticoagulants (NOACs) and extremes of body weight-a systematic literature review. PG - 565-572 LID - 10.1007/s00392-017-1102-5 [doi] AB - The non-vitamin K antagonist oral anticoagulants (NOACs) exert their anticoagulant effect closely related to their plasma concentrations. Since their distribution volume is related to body weight (and its correlates, i.e., surface area and body mass index, BMI), extremes in body weight may affect their efficacy or safety. Four NOACs are currently available for long-term use, with few exceptions, in atrial fibrillation and venous thromboembolism: the direct thrombin inhibitor dabigatran etexilate, and the factor (F) Xa inhibitors rivaroxaban, apixaban, and edoxaban. Experience in patients with low (<50 kg) or extremely high (>150 kg) body weight is still quite limited, as such patients were rare in registration trials and sometimes directly excluded. In general, increased bleeding and higher mortality rates are observed in patients weighing <50 kg compared with patients weighing 50-100 kg. This may however also be explained by the presence of underlying conditions such as cancer. At the opposite end of the spectrum of body weight, lower antithrombotic efficacy may occur, perhaps due to the dilutional effect of a higher distribution volume. In this article, we review the pertinent literature and analyze the effects of low or high body weight on anticoagulant activity and clinical outcomes of the NOACs, their dose recommendations, and areas of uncertainty. FAU - De Caterina, Raffaele AU - De Caterina R AUID- ORCID: 0000-0003-1637-574X AD - "G. d'Annunzio" University and Center of Excellence on Aging - CeSI-Met, Chieti, Italy. rdecater@unich.it. AD - University of Birmingham Institute of Cardiovascular Science, City Hospital, Birmingham, UK. rdecater@unich.it. FAU - Lip, Gregory Y H AU - Lip GYH AD - "G. d'Annunzio" University and Center of Excellence on Aging - CeSI-Met, Chieti, Italy. AD - University of Birmingham Institute of Cardiovascular Science, City Hospital, Birmingham, UK. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20170410 PL - Germany TA - Clin Res Cardiol JT - Clinical research in cardiology : official journal of the German Cardiac Society JID - 101264123 RN - 0 (Anticoagulants) RN - 12001-79-5 (Vitamin K) SB - IM MH - Administration, Oral MH - Anticoagulants/*administration & dosage/pharmacokinetics MH - *Body Weight MH - Dose-Response Relationship, Drug MH - Humans MH - Venous Thromboembolism/metabolism/*prevention & control MH - Vitamin K/*antagonists & inhibitors OTO - NOTNLM OT - BMI OT - Bleeding OT - Body mass index OT - Body weight OT - Mortality OT - NOACs OT - Non-vitamin K antagonist oral anticoagulants OT - Obesity OT - Stroke EDAT- 2017/04/12 06:00 MHDA- 2018/09/01 06:00 CRDT- 2017/04/12 06:00 PHST- 2017/01/19 00:00 [received] PHST- 2017/03/02 00:00 [accepted] PHST- 2017/04/12 06:00 [pubmed] PHST- 2018/09/01 06:00 [medline] PHST- 2017/04/12 06:00 [entrez] AID - 10.1007/s00392-017-1102-5 [pii] AID - 10.1007/s00392-017-1102-5 [doi] PST - ppublish SO - Clin Res Cardiol. 2017 Aug;106(8):565-572. doi: 10.1007/s00392-017-1102-5. Epub 2017 Apr 10. PMID- 27225418 OWN - NLM STAT- MEDLINE DCOM- 20170711 LR - 20181202 IS - 0957-154X (Print) IS - 0957-154X (Linking) VI - 27 IP - 3 DP - 2016 Sep TI - Taphophobia and 'life preserving coffins' in the nineteenth century. PG - 345-9 LID - 10.1177/0957154X16650100 [doi] AB - In 1891 the Italian psychiatrist Enrico Morselli (1852-1929) described taphophobia, defining it as an extreme condition of claustrophobia due to the fear of being buried alive. This rare psychopathological phenomenon reflects an ancient fear, and its origin is not known. Taphophobia is closely linked to the problem of apparent death and premature burial. In the nineteenth century, scientists and authors paid particular attention to the issue of apparent death, and special devices (safety coffins) were invented to ensure that premature burial was avoided. Nowadays taphophobia is quite a rare psychiatric disorder; different forms of social anxiety disorders are much more widespread. Its modern equivalent could be the fear of organs harvested from a patient who is still alive. CI - © The Author(s) 2016. FAU - Cascella, Marco AU - Cascella M AD - National Cancer Institute "G. Pascale" Foundation, Naples, Italy m.cascella@istitutotumori.na.it. LA - eng PT - Biography PT - Historical Article PT - Journal Article PT - Portrait DEP - 20160525 PL - England TA - Hist Psychiatry JT - History of psychiatry JID - 9013819 MH - *Attitude to Death MH - Burial/*history MH - History, 19th Century MH - History, 20th Century MH - Humans MH - Italy MH - Phobic Disorders/*history MH - Psychiatry/*history PS - Morselli E FPS - Morselli, Enrico OTO - NOTNLM OT - Apparent death OT - claustrophobia OT - death diagnosis OT - safety coffin OT - taphophobia EDAT- 2016/05/27 06:00 MHDA- 2017/07/14 06:00 CRDT- 2016/05/27 06:00 PHST- 2016/05/27 06:00 [entrez] PHST- 2016/05/27 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] AID - 0957154X16650100 [pii] AID - 10.1177/0957154X16650100 [doi] PST - ppublish SO - Hist Psychiatry. 2016 Sep;27(3):345-9. doi: 10.1177/0957154X16650100. Epub 2016 May 25. PMID- 27562605 OWN - NLM STAT- MEDLINE DCOM- 20171020 LR - 20181202 IS - 1365-2486 (Electronic) IS - 1354-1013 (Linking) VI - 23 IP - 1 DP - 2017 Jan TI - Thermal limits of leaf metabolism across biomes. PG - 209-223 LID - 10.1111/gcb.13477 [doi] AB - High-temperature tolerance in plants is important in a warming world, with extreme heat waves predicted to increase in frequency and duration, potentially leading to lethal heating of leaves. Global patterns of high-temperature tolerance are documented in animals, but generally not in plants, limiting our ability to assess risks associated with climate warming. To assess whether there are global patterns in high-temperature tolerance of leaf metabolism, we quantified T(crit) (high temperature where minimal chlorophyll a fluorescence rises rapidly and thus photosystem II is disrupted) and T(max) (temperature where leaf respiration in darkness is maximal, beyond which respiratory function rapidly declines) in upper canopy leaves of 218 plant species spanning seven biomes. Mean site-based T(crit) values ranged from 41.5 °C in the Alaskan arctic to 50.8 °C in lowland tropical rainforests of Peruvian Amazon. For T(max) , the equivalent values were 51.0 and 60.6 °C in the Arctic and Amazon, respectively. T(crit) and T(max) followed similar biogeographic patterns, increasing linearly (˜8 °C) from polar to equatorial regions. Such increases in high-temperature tolerance are much less than expected based on the 20 °C span in high-temperature extremes across the globe. Moreover, with only modest high-temperature tolerance despite high summer temperature extremes, species in mid-latitude (~20-50°) regions have the narrowest thermal safety margins in upper canopy leaves; these regions are at the greatest risk of damage due to extreme heat-wave events, especially under conditions when leaf temperatures are further elevated by a lack of transpirational cooling. Using predicted heat-wave events for 2050 and accounting for possible thermal acclimation of T(crit) and T(max) , we also found that these safety margins could shrink in a warmer world, as rising temperatures are likely to exceed thermal tolerance limits. Thus, increasing numbers of species in many biomes may be at risk as heat-wave events become more severe with climate change. CI - © 2016 John Wiley & Sons Ltd. FAU - O'sullivan, Odhran S AU - O'sullivan OS AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - Department of Animal and Plant Sciences, University of Sheffield, Alfred Denny Building, Western Bank, Sheffield, S10 2TN, UK. FAU - Heskel, Mary A AU - Heskel MA AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - The Ecosystems Center, Marine Biological Laboratory, Woods Hole, MA, 02544, USA. FAU - Reich, Peter B AU - Reich PB AD - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, 2751, Australia. AD - Department of Forest Resources, University of Minnesota, 1530 Cleveland Avenue North, St. Paul, MN, 55108, USA. FAU - Tjoelker, Mark G AU - Tjoelker MG AD - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, 2751, Australia. FAU - Weerasinghe, Lasantha K AU - Weerasinghe LK AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - Faculty of Agriculture, University of Peradeniya, Peradeniya, 20400, Sri Lanka. FAU - Penillard, Aurore AU - Penillard A AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. FAU - Zhu, Lingling AU - Zhu L AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - ARC Centre of Excellence in Plant Energy Biology, Research School of Biology, The Australian National University, Building 134, Canberra, ACT, 2601, Australia. FAU - Egerton, John J G AU - Egerton JJ AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. FAU - Bloomfield, Keith J AU - Bloomfield KJ AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. FAU - Creek, Danielle AU - Creek D AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - Hawkesbury Institute for the Environment, Western Sydney University, Penrith, NSW, 2751, Australia. FAU - Bahar, Nur H A AU - Bahar NH AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - ARC Centre of Excellence in Plant Energy Biology, Research School of Biology, The Australian National University, Building 134, Canberra, ACT, 2601, Australia. FAU - Griffin, Kevin L AU - Griffin KL AD - Department of Earth and Environment Sciences, Columbia University, Palisades, NY, 10964, USA. FAU - Hurry, Vaughan AU - Hurry V AD - Umeå Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, SE-901 84, Sweden. FAU - Meir, Patrick AU - Meir P AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - School of Geosciences, University of Edinburgh, Edinburgh, EH9 3FF, UK. FAU - Turnbull, Matthew H AU - Turnbull MH AD - Centre for Integrative Ecology, School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand. FAU - Atkin, Owen K AU - Atkin OK AD - Division of Plant Sciences, Research School of Biology, The Australian National University, Building 46, Canberra, ACT, 2601, Australia. AD - ARC Centre of Excellence in Plant Energy Biology, Research School of Biology, The Australian National University, Building 134, Canberra, ACT, 2601, Australia. LA - eng PT - Journal Article DEP - 20161014 PL - England TA - Glob Chang Biol JT - Global change biology JID - 9888746 RN - 1406-65-1 (Chlorophyll) RN - YF5Q9EJC8Y (Chlorophyll A) SB - IM MH - *Acclimatization MH - Animals MH - Arctic Regions MH - Chlorophyll MH - Chlorophyll A MH - *Climate Change MH - Plant Leaves/*metabolism MH - Temperature OTO - NOTNLM OT - T crit OT - T max OT - heat waves OT - high-temperature tolerance OT - latitudinal patterns OT - photosynthesis OT - respiration OT - temperature extremes EDAT- 2016/08/27 06:00 MHDA- 2017/10/21 06:00 CRDT- 2016/08/27 06:00 PHST- 2016/03/12 00:00 [received] PHST- 2016/07/29 00:00 [revised] PHST- 2016/08/13 00:00 [accepted] PHST- 2016/08/27 06:00 [pubmed] PHST- 2017/10/21 06:00 [medline] PHST- 2016/08/27 06:00 [entrez] AID - 10.1111/gcb.13477 [doi] PST - ppublish SO - Glob Chang Biol. 2017 Jan;23(1):209-223. doi: 10.1111/gcb.13477. Epub 2016 Oct 14. PMID- 30363076 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220321 IS - 2093-7911 (Print) IS - 2093-7997 (Electronic) IS - 2093-7911 (Linking) VI - 9 IP - 1 DP - 2018 Mar TI - Human Error Probability Assessment During Maintenance Activities of Marine Systems. PG - 42-52 LID - 10.1016/j.shaw.2017.06.008 [doi] AB - BACKGROUND: Maintenance operations on-board ships are highly demanding. Maintenance operations are intensive activities requiring high man-machine interactions in challenging and evolving conditions. The evolving conditions are weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress. For example, extreme weather condition affects seafarers' performance, increasing the chances of error, and, consequently, can cause injuries or fatalities to personnel. An effective human error probability model is required to better manage maintenance on-board ships. The developed model would assist in developing and maintaining effective risk management protocols. Thus, the objective of this study is to develop a human error probability model considering various internal and external factors affecting seafarers' performance. METHODS: The human error probability model is developed using probability theory applied to Bayesian network. The model is tested using the data received through the developed questionnaire survey of >200 experienced seafarers with >5 years of experience. The model developed in this study is used to find out the reliability of human performance on particular maintenance activities. RESULTS: The developed methodology is tested on the maintenance of marine engine's cooling water pump for engine department and anchor windlass for deck department. In the considered case studies, human error probabilities are estimated in various scenarios and the results are compared between the scenarios and the different seafarer categories. The results of the case studies for both departments are also compared. CONCLUSION: The developed model is effective in assessing human error probabilities. These probabilities would get dynamically updated as and when new information is available on changes in either internal (i.e., training, experience, and fatigue) or external (i.e., environmental and operational conditions such as weather conditions, workplace temperature, ship motion, noise and vibration, and workload and stress) factors. FAU - Islam, Rabiul AU - Islam R AD - National Centre for Maritime Engineering and Hydrodynamics (NCMEH), Australian Maritime College (AMC), University of Tasmania, Launceston, Australia. AD - Centre for Risk, Integrity and Safety Engineering (C-RISE), Process Engineering Department, Memorial University of Newfoundland, St. John's, NL, Canada. FAU - Khan, Faisal AU - Khan F AD - National Centre for Maritime Engineering and Hydrodynamics (NCMEH), Australian Maritime College (AMC), University of Tasmania, Launceston, Australia. AD - Centre for Risk, Integrity and Safety Engineering (C-RISE), Process Engineering Department, Memorial University of Newfoundland, St. John's, NL, Canada. FAU - Abbassi, Rouzbeh AU - Abbassi R AD - National Centre for Maritime Engineering and Hydrodynamics (NCMEH), Australian Maritime College (AMC), University of Tasmania, Launceston, Australia. FAU - Garaniya, Vikram AU - Garaniya V AD - National Centre for Maritime Engineering and Hydrodynamics (NCMEH), Australian Maritime College (AMC), University of Tasmania, Launceston, Australia. LA - eng PT - Journal Article DEP - 20170628 PL - Korea (South) TA - Saf Health Work JT - Safety and health at work JID - 101542940 PMC - PMC6111134 OTO - NOTNLM OT - human error probability OT - human factors OT - maintenance operation OT - marine system OT - reliability assessment EDAT- 2018/10/27 06:00 MHDA- 2018/10/27 06:01 PMCR- 2017/06/28 CRDT- 2018/10/27 06:00 PHST- 2017/04/05 00:00 [received] PHST- 2017/06/07 00:00 [revised] PHST- 2017/06/19 00:00 [accepted] PHST- 2018/10/27 06:00 [entrez] PHST- 2018/10/27 06:00 [pubmed] PHST- 2018/10/27 06:01 [medline] PHST- 2017/06/28 00:00 [pmc-release] AID - S2093-7911(17)30183-X [pii] AID - 10.1016/j.shaw.2017.06.008 [doi] PST - ppublish SO - Saf Health Work. 2018 Mar;9(1):42-52. doi: 10.1016/j.shaw.2017.06.008. Epub 2017 Jun 28. PMID- 39556458 OWN - NLM STAT- Publisher LR - 20241118 IS - 1538-957X (Electronic) IS - 1538-9588 (Linking) DP - 2024 Nov 18 TI - A novel approach for safety assessment at unsignalized intersections: Integrating spatial metrics into postencroachment time analysis under heterogeneous traffic conditions. PG - 1-8 LID - 10.1080/15389588.2024.2416485 [doi] AB - OBJECTIVE: Evaluating the safety risks at unsignalized intersections becomes increasingly complex amid conditions of dense traffic flow, a heterogeneous mix of vehicles, nonadherence to lane demarcations, and reactive driving techniques. Understanding driver behavior under such varying circumstances is crucial for accurately assessing the potential hazards present at these intersections. The study aims to assess the safety of unsignalized intersections by incorporating both spatial and temporal variables under heterogeneous conditions. METHODS: The study presents a new safety indicator, dynamic postencroachment time (DPET), formulated to encapsulate both the spatial and temporal variables of heterogeneous traffic. Six unsignalized intersections were selected as the study areas in Assam, India, to assess the new indicator for merging and crossing conflicts. A videographic survey of the intersections was done to obtain vehicles' trajectory data and capture their conflict behaviors based on their position, speed, and steering angle. The peak over threshold (POT) approach of extreme value theory (EVT) was used to examine the feasibility of the indicator, and the methodology was validated using 4 years of crash data. RESULTS: The result showed that a common threshold of 0.7 s from the POT approach is sufficient to identify severe conflicts. Furthermore, the threshold level yielded a shape parameter greater than -0.5, affirming that the maximum likelihood estimates retain the standard asymptotic attributes associated with EVT. The DPET approach estimated more crashes than observed fatal crashes, reflecting its ability to capture extreme events at a lower threshold. In comparison, the traditional PET approach estimated fewer crashes due to higher values influenced by evasive actions. Graphical analysis demonstrated a strong correlation between the observed crash data over 4 years and the estimated crashes derived from the EVT models. CONCLUSIONS: Integrating spatial variables in PET analysis provides a more robust measure for conflict analysis and assessment of potential traffic conflicts at unsignalized intersections. The subsequent validation of the model with actual crash data highlights its practical applicability in enhancing road safety. The findings from the study provide a promising direction for future research and the potential for widespread implementation in traffic management systems. FAU - Lyngdoh, George Kennedy AU - Lyngdoh GK AD - Department of Civil Engineering, National Institute of Technology Silchar, Silchar, India. FAU - Jena, Suprava AU - Jena S AD - Department of Civil Engineering, National Institute of Technology Silchar, Silchar, India. LA - eng PT - Journal Article DEP - 20241118 PL - England TA - Traffic Inj Prev JT - Traffic injury prevention JID - 101144385 SB - IM OTO - NOTNLM OT - Unsignalized intersection OT - crash data OT - extreme value theory OT - postencroachment time OT - surrogate safety measures OT - trajectory data EDAT- 2024/11/18 22:18 MHDA- 2024/11/18 22:18 CRDT- 2024/11/18 12:23 PHST- 2024/11/18 22:18 [medline] PHST- 2024/11/18 22:18 [pubmed] PHST- 2024/11/18 12:23 [entrez] AID - 10.1080/15389588.2024.2416485 [doi] PST - aheadofprint SO - Traffic Inj Prev. 2024 Nov 18:1-8. doi: 10.1080/15389588.2024.2416485. PMID- 12358176 OWN - NLM STAT- MEDLINE DCOM- 20030401 LR - 20190726 IS - 0147-8389 (Print) IS - 0147-8389 (Linking) VI - 25 IP - 8 DP - 2002 Aug TI - Electronic security systems and active implantable medical devices. PG - 1235-58 AB - How do active implantable medical devices react in the presence of strong magnetic fields in the frequency range between extremely low frequency (ELF) to radiofrequency (RF) as they are emitted by electronic security systems (ESS)? There are three different sorts of ESSs: electronic article surveillance (EAS) devices, metal detector (MDS) devices, and radiofrequency identification (RFID) systems. Common to all is the production of magnetic fields. There is an abundance of literature concerning interference by ESS gates with respect to if there is an influence possible and if such an influence can bear a risk for the AIMD wearers. However, there has been no attempt to study the physical mechanism nor to develop a model of how and under which conditions magnetic fields can influence pacemakers and defibrillators and how they could be disarmed by technological means. It is too often assumed that interference of AIMD with ESS is inevitable. Exogenous signals of similar intensity and rhythm to heart signals can be misinterpreted and, thus, confuse the implant. Important for the interference coupling mechanism is the differentiation between a "unipolar" and a "bipolar" system. With respect to magnetic fields, the left side implanted pacemaker is the most unfavorable case as the lead forms approximately a semicircular area of maximum 225 cm2 into which a voltage can be induced. This assumption yields an interference coupling model that can be expressed by simple mathematics. The worst-case conditions for induced interference voltages are a coupling area of 225 cm2 that is representative for a large human, a homogeneous magnetic field perpendicular to the area formed by the lead, and a unipolar ventricular pacemaker system that is implanted on the left side of the thorax and has the highest interference sensitivity. In bipolar systems the fields must be 17 times larger when compared to a unipolar system to have the same effect. The magnetic field for interfering with ICDs must be 1.7 stronger than that of the most sensitive unipolar pacemaker. The lowest interference thresholds measured over the last 10 years in the low frequency range (16 2/3 Hz-24 kHz) together with thresholds > 24 kHz that were supplied by the CETECOM study are listed. Both sets of data together with the coupling model, allow for judging which fields of ESSs could influence AIMDs. From measurements at gate antennas, it is possible to derive a "maximum allowed field" curve over the whole frequency range, below which no interference will occur. Comparison of data from literature with these maximum allowed fields confirm the correctness of the calculations. Thus, it is possible to predict interference situations in gates if the magnetic field is known. If all future pacemakers were to have the immunity against interference of the better 50% of today's pacemakers, the magnetic field ceiling values could be at least four times higher. The same is true if the ventricular sensitivity is routinely set at 7 mV. Pacemaker manufacturers should consider filter improvement with modern technology, but gate manufacturers should not claim the privilege of being out of bounds. FAU - Irnich, Werner AU - Irnich W AD - Department of Legal Medicine, University Hospital, Giessen, Germany. werner.irnich@technik.med.uni-giessen.de LA - eng PT - Journal Article PT - Review PL - United States TA - Pacing Clin Electrophysiol JT - Pacing and clinical electrophysiology : PACE JID - 7803944 SB - IM MH - Defibrillators, Implantable MH - Electromagnetic Fields MH - Humans MH - Pacemaker, Artificial MH - *Prostheses and Implants MH - Safety MH - Security Measures/*standards RF - 47 EDAT- 2002/10/03 04:00 MHDA- 2003/04/02 05:00 CRDT- 2002/10/03 04:00 PHST- 2002/10/03 04:00 [pubmed] PHST- 2003/04/02 05:00 [medline] PHST- 2002/10/03 04:00 [entrez] AID - 10.1046/j.1460-9592.2002.01235.x [doi] PST - ppublish SO - Pacing Clin Electrophysiol. 2002 Aug;25(8):1235-58. doi: 10.1046/j.1460-9592.2002.01235.x. PMID- 32768012 OWN - NLM STAT- MEDLINE DCOM- 20200814 LR - 20201218 IS - 2213-3763 (Electronic) IS - 0019-4832 (Print) IS - 0019-4832 (Linking) VI - 72 IP - 3 DP - 2020 May-Jun TI - Cardiological society of India document on safety measure during echo evaluation of cardiovascular disease in the time of COVID-19. PG - 145-150 LID - S0019-4832(20)30122-X [pii] LID - 10.1016/j.ihj.2020.05.016 [doi] AB - An echocardiographic investigation is one of the key modalities of diagnosis in cardiology. There has been a rising presence of cardiological comorbidities in patients positive for COVID-19. Hence, it is becoming extremely essential to look into the correct safety precautions, healthcare professionals must take while conducting an echo investigation. The decision matrix formulated for conducting an echocardiographic evaluation is based on presence or absence of cardiological comorbidity vis-à-vis positive, suspected or negative for COVID-19. The safety measures have been constructed keeping in mind the current safety precautions by WHO, CDC and MoHFW, India. CI - Copyright © 2020. Published by Elsevier B.V. FAU - Gupta, Rakesh AU - Gupta R AD - JROP Institute of Echocardiography, Ultrasound & Vascular Doppler, JROP Healthcare Pvt. Ltd., C-1/16, Ashok Vihar-II, Delhi, 110052, India; JROP Charak Heart City, MD City Hospital, Model Town Northex, Delhi, 110009, India. Electronic address: rakeshecho@gmail.com. FAU - Das, Mrinal Kanti AU - Das MK AD - C K Birla Group of Hospitals (BMB and CMRI), Kolkata, West Bengal, India. FAU - Mohanan, P P AU - Mohanan PP AD - Westfort Hi-Tech Hospital, Thrissur, Kerala, India. FAU - Deb, Pradip K AU - Deb PK AD - Daffodil Hospital, Kolkata, West Bengal, India. FAU - Parashar, S K AU - Parashar SK AD - Metro Heart Hospital, Lajpat Nagar, New Delhi, India. FAU - Chopra, H K AU - Chopra HK AD - Moolchand Medcity, New Delhi, India. FAU - Shrivastava, Sameer AU - Shrivastava S AD - Fortis Escort Heart Institute, Okhla, New Delhi, India. FAU - Guha, Santanu AU - Guha S AD - Calcutta Medical College Hospital, Kolkata, West Bengal, India. FAU - Goswami, Kewal C AU - Goswami KC AD - All India Institute of Medical Sciences, New Delhi, India. FAU - Yadav, Rakesh AU - Yadav R AD - All India Institute of Medical Sciences, New Delhi, India. FAU - Alagesan, R AU - Alagesan R AD - K M Speciality Hospital, Chennai, India. FAU - Amuthan, V AU - Amuthan V AD - Jeyalakshmi Heart Center, Madurai, Tamilnadu, India. FAU - Bansal, M AU - Bansal M AD - Medanta, The Medicity, New Delhi, India. FAU - Chakraborty, R N AU - Chakraborty RN AD - Medica Group of Superspeciality Hospitals, Kolkata, West Bengal, India. FAU - Chakraborti, N AU - Chakraborti N AD - Medica Group of Superspeciality Hospitals, Kolkata, West Bengal, India. FAU - Chandra, S AU - Chandra S AD - King George's Medical University, Lucknow, India. FAU - Chatterjee, A AU - Chatterjee A AD - NH-Imperial, Chittagong, Bangladesh. FAU - Chatterjee, D AU - Chatterjee D AD - Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India. FAU - Chatterjee, S S AU - Chatterjee SS AD - Cardiology Clinic, Kolkata, India. FAU - Dutta, A L AU - Dutta AL AD - Peerless Hospital. Kolkata, India. FAU - De, A AU - De A AD - Apollo Gleneagles Hospital, Kolkata, India. FAU - Garg, A AU - Garg A AD - Jaipur Heart Institute, Jaipur, India. FAU - Garg, V K AU - Garg VK AD - R D Gardi Medical College, Ujjain, India. FAU - Goyal, A AU - Goyal A AD - Bani Park Hospital, Jaipur, India. FAU - Goyal, N K AU - Goyal NK AD - BLK Superspeciality Hospital, New Delhi, India. FAU - Govind, S C AU - Govind SC AD - Narayana Healthcity, Bengaluru, India. FAU - Gupta, V K AU - Gupta VK AD - Kishori Ram Hospital & Diabetes Care Centre, Bhatinda, India. FAU - Hasija, Pradeep K AU - Hasija PK AD - Military Hospital, Chennai, India. FAU - Jabir, A AU - Jabir A AD - Lisie Hospital Kochi, Kerala, India. FAU - Jain, P AU - Jain P AD - Lifeline Superspeciality Hospital, Jhansi, India. FAU - Jain, V AU - Jain V AD - Choithram Hospital &R.C., Indore, India. FAU - Jayagopal, P B AU - Jayagopal PB AD - Laxmi Hospital, Palakkad, Kerala, India. FAU - Kasliwal, R R AU - Kasliwal RR AD - Medanta Medicity, Gurgaon, India. FAU - Katyal, V K AU - Katyal VK AD - PGIMS, ROHTAK, India. FAU - Kerkar, P G AU - Kerkar PG AD - KEM Hospital, Mumbai, India. FAU - Khan, Amal Kumar AU - Khan AK AD - AMRI Hospital, Salt Lake, Kolkata, India. FAU - Khanna, N N AU - Khanna NN AD - Apollo Hospital, New Delhi, India. FAU - Mandal, M AU - Mandal M AD - NRS Medical College, Kolkata, India. FAU - Majumder, B AU - Majumder B AD - R.G. Kar Medical College & Hospital, Kolkata, India. FAU - Mishra, S S AU - Mishra SS AD - Hi-Tech Medical College and Hospital, Bhubaneshwar, India. FAU - Meena, C B AU - Meena CB AD - SMS Medical College, Jaipur, Rajasthan. FAU - Naik, N AU - Naik N AD - AIIMS, New Delhi, India. FAU - Narain, V S AU - Narain VS AD - King George's Medical University, Lucknow, India. FAU - Pancholia, A K AU - Pancholia AK AD - Arihant Hospital & Research Center, Indore, India. FAU - Pathak, L A AU - Pathak LA AD - Nanavati Heart Institute, Nanavati Superspeciality Hospital, Mumbai, India. FAU - Ponde, C K AU - Ponde CK AD - PD Hinduja National Hospital & RC, Mumbai, India. FAU - Raghu, K AU - Raghu K AD - Care Hospital, Hyderabad, India. FAU - Ray, S AU - Ray S AD - Vivekananda Institute of Medical Sciences, Kolkata, India. FAU - Roy, D AU - Roy D AD - Rabindranath Tagore International Institute of Cardiac Sciences, Kolkata, India. FAU - Sarma, D AU - Sarma D AD - Jorhat Christian Medical Centre Hospital, Jorhat, Assam, India. FAU - Shanmugasundarum, S AU - Shanmugasundarum S AD - Billroth Hospital, Chennai, India. FAU - Singh, B P AU - Singh BP AD - IGIMS, Patna, India. FAU - Tyagi, S AU - Tyagi S AD - GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India. FAU - Vijayaraghavan, G AU - Vijayaraghavan G AD - Kerala Institute of Medical Sciences, Trivandrum, India. FAU - Wander, G S AU - Wander GS AD - Hero DMC Heart Institute, Ludhiana, India. FAU - Wardhan, Harsh AU - Wardhan H AD - Mahatma Gandhi Medical College and Hospital, Jaipur, India. FAU - Nanda, N C AU - Nanda NC AD - University of Alabama at Birmingham, Birmingham, AL, USA. LA - eng PT - Journal Article PT - Review DEP - 20200526 PL - India TA - Indian Heart J JT - Indian heart journal JID - 0374675 SB - IM MH - COVID-19 MH - Cardiology MH - Cardiovascular Diseases/*diagnostic imaging/epidemiology MH - Coronavirus Infections/epidemiology/*prevention & control MH - Cross Infection/*prevention & control MH - Echocardiography/*methods MH - Female MH - Humans MH - India MH - Infection Control/methods MH - Male MH - Pandemics/*prevention & control/statistics & numerical data MH - *Patient Safety MH - Pneumonia, Viral/epidemiology/*prevention & control MH - Practice Guidelines as Topic MH - Severe Acute Respiratory Syndrome/epidemiology/prevention & control MH - Societies, Medical PMC - PMC7250084 OTO - NOTNLM OT - COVID -19 OT - Cardiological Society of India OT - Cardiovascular evaluation OT - Echocardiography OT - Safety measures COIS- Declaration of competing interest The author has none to declare. EDAT- 2020/08/10 06:00 MHDA- 2020/08/15 06:00 PMCR- 2020/05/01 CRDT- 2020/08/10 06:00 PHST- 2020/05/08 00:00 [received] PHST- 2020/05/15 00:00 [revised] PHST- 2020/05/19 00:00 [accepted] PHST- 2020/08/10 06:00 [entrez] PHST- 2020/08/10 06:00 [pubmed] PHST- 2020/08/15 06:00 [medline] PHST- 2020/05/01 00:00 [pmc-release] AID - S0019-4832(20)30122-X [pii] AID - 10.1016/j.ihj.2020.05.016 [doi] PST - ppublish SO - Indian Heart J. 2020 May-Jun;72(3):145-150. doi: 10.1016/j.ihj.2020.05.016. Epub 2020 May 26. PMID- 23745447 OWN - NLM STAT- MEDLINE DCOM- 20130625 LR - 20131121 IS - 0034-8376 (Print) IS - 0034-8376 (Linking) VI - 65 IP - 1 DP - 2013 Jan-Feb TI - [Factors relating to falls in hospitalized patients]. PG - 88-93 AB - Falls are one indicator of quality, and are classified as an adverse event, where the consequences of these can range from mild to severe and even fatal; the Joint Commission International (JCI) reports them as the sixth most frequently reported event in the database Sentinel Events. A challenge for health institutions is to maintain a risk-free environment, ensuring users to achieve the expected improvement; however each hospital is extremely complex due to the constant interaction of the person with their environment, making it necessary to have clear understanding of the variables that can influence the situation. To consider a risk-free environment must be considered preventive actions to minimize risk factors, which can be both intrinsic and extrinsic, first includes the particular characteristics of the person, and the latter refers to the hospital environment. It is important to consider that within the intrinsic factors, although they cannot be completely modified, is necessary to make an assessment and identify risks to promote preventive measures, respect to the extrinsic; is responsibility of the multidisciplinary health team to identify and eliminate the causes that contribute to the presence of falls. FAU - Olvera-Arreola, Sandra Sonalí AU - Olvera-Arreola SS AD - Instituto Nacional de Cardiología Ignacio Chávez. sandra.olvera@cardiologia.org.mx FAU - Hernández-Cantoral, Alicia AU - Hernández-Cantoral A FAU - Arroyo-Lucas, Silvino AU - Arroyo-Lucas S FAU - Nava-Galán, Ma Guadalupe AU - Nava-Galán MG FAU - Zapien-Vázquez, María de los Angeles AU - Zapien-Vázquez Mde L FAU - Pérez-López, Maria Teresa AU - Pérez-López MT FAU - Cárdenas-Sánchez, Patricia Adriana AU - Cárdenas-Sánchez PA LA - spa PT - English Abstract PT - Journal Article PT - Review TT - Factores relacionados con la presencia de caídas en pacientes hospitalizados. PL - Mexico TA - Rev Invest Clin JT - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JID - 9421552 SB - IM MH - Accidental Falls/*prevention & control/statistics & numerical data MH - Age Factors MH - Aged MH - Cardiovascular Diseases/physiopathology MH - Confusion MH - Disease Susceptibility MH - Drug-Related Side Effects and Adverse Reactions MH - Female MH - Hospital Design and Construction MH - Humans MH - *Inpatients/psychology MH - Male MH - Mobility Limitation MH - Nervous System Diseases/physiopathology MH - *Patient Safety MH - Risk Factors MH - Risk Management EDAT- 2013/06/12 06:00 MHDA- 2013/06/26 06:00 CRDT- 2013/06/11 06:00 PHST- 2013/06/11 06:00 [entrez] PHST- 2013/06/12 06:00 [pubmed] PHST- 2013/06/26 06:00 [medline] PST - ppublish SO - Rev Invest Clin. 2013 Jan-Feb;65(1):88-93. PMID- 12904148 OWN - NLM STAT- MEDLINE DCOM- 20030826 LR - 20191107 IS - 1474-0338 (Print) IS - 1474-0338 (Linking) VI - 1 IP - 2 DP - 2002 Jul TI - Risk-benefit assessment of angiotensin II receptor antagonists. PG - 137-52 AB - Inhibiting the renin-angiotensin-aldosterone system through the use of angiotensin-converting enzyme (ACE) inhibitors has proven very useful in the treatment of hypertension, congestive heart failure (CHF) and progressive renal failure. More recently, agents that directly block the angiotensin II Type 1 (AT(1)) receptor--angiotensin II receptor antagonists (AIIRAs)--have been developed. These agents are thought to have a more specific mechanism of action since they do not affect other hormone systems as do the ACE inhibitors. Whether such specificity results in a different efficacy profile is still being determined. However, these drugs are extremely well-tolerated and very safe. AIIRAs are effective in the reduction of both systolic and diastolic blood pressure and compare favourably to other classes of agents. Recent results indicate that at least one AIIRA has a favourable effect on stroke in hypertensive patients with left ventricular hypertrophy. Additional studies with other members of the class will provide further information on similar outcomes. In CHF patients, ACE inhibitors remain the drug of choice and AIIRAs are best utilised in patients who cannot tolerate an ACE inhibitor or in those receiving an ACE inhibitor who cannot tolerate a beta-blocker and need additional therapy. AIIRAs are effective in slowing the progression of renal failure in patients with Type II diabetes and may be effective in other proteinuric conditions. Whether they are more or less effective than ACE inhibitors is unknown. Overall, AIIRAs represent an important addition to the armamentarium of cardiovascular therapies with an excellent safety record and an emerging profile of utility in multiple cardiovascular conditions. FAU - Shusterman, Neil AU - Shusterman N AD - University of Pennsylvania School of Medicine, Presbyterian Medical Center, 39th & Market Street, Philadelphia, PA 19104, USA. NHShusterman@comcast.net LA - eng PT - Journal Article PT - Review PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 0 (Receptor, Angiotensin, Type 2) SB - IM MH - *Angiotensin Receptor Antagonists MH - Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use MH - Clinical Trials as Topic MH - Headache/chemically induced MH - Heart Failure/*drug therapy MH - Humans MH - Kidney Failure, Chronic/*drug therapy MH - Receptor, Angiotensin, Type 2 MH - Renin-Angiotensin System/*drug effects MH - Risk Assessment MH - Safety RF - 105 EDAT- 2003/08/09 05:00 MHDA- 2003/08/27 05:00 CRDT- 2003/08/09 05:00 PHST- 2003/08/09 05:00 [pubmed] PHST- 2003/08/27 05:00 [medline] PHST- 2003/08/09 05:00 [entrez] AID - 10.1517/14740338.1.2.137 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2002 Jul;1(2):137-52. doi: 10.1517/14740338.1.2.137. PMID- 10955267 OWN - NLM STAT- MEDLINE DCOM- 20001207 LR - 20191104 IS - 0883-9212 (Print) IS - 0883-9212 (Linking) VI - 20 IP - 4 DP - 2000 Jul-Aug TI - A survey of exercise testing: methods, utilization, interpretation, and safety in the VAHCS. PG - 251-8 AB - BACKGROUND: Healthcare organizations are being graded in terms of their adherence to practice guidelines. The authors sought information on practice patterns of exercise testing within the Veterans Affairs Health Care System (VAHCS) to determine how well current practice patterns adhere to current guidelines. In addition, we sought to update past surveys to determine methods, indications, utilization of alternative diagnostic modalities, criteria for interpretation, safety, and physician supervision of exercise testing within the VAHCS. METHODS: Questionnaires were sent to 72 of the largest Veterans Affairs Medical Centers with cardiology divisions. The centers were queried regarding volume and type of exercise testing (standard, nuclear, and echocardiographic), indications, safety, protocols used, and criteria for interpretation. RESULTS: Seventy-one questionnaires were returned, comprising a total of 75,828 exercise tests performed within the last year. Virtually all indications for exercise testing fit the American Heart Association/American College of Cardiology (AHA/ACC) guidelines Class I criteria; 46% of patients were tested for the evaluation of chest pain; 14% were tested to evaluate patients at high risk for coronary artery disease; 10% were preoperative evaluations; and 8% were post-myocardial infarction evaluations. The most commonly used diagnostic test was the standard exercise electrocardiogram; a patient was five times more likely to undergo a standard exercise electrocardiogram or nuclear exercise test than an exercise or pharmacologic echocardiogram. The largest proportion of centers (49%) used 1.0-mm horizontal or downsloping ST depression as a criterion for an abnormal test, although 22% considered 1.5-mm upsloping ST depression to be abnormal, and 25% relied on a treadmill score. Seventy-eight percent of respondents used the treadmill, and of these, 82% used the Bruce or modified Bruce protocol. Four major cardiac events were reported (three myocardial infarctions, one sustained ventricular tachycardia) representing an event rate of 1.2/10,000. A physician was present during 73% of all standard exercise tests; 21% of respondents reported that a physician was required to be present "only for high-risk patients." CONCLUSION: Indications for exercise testing are in close agreement with the AHA/ACC guidelines; thus, the test continues to have an important role in diagnosis and prognosis among patients with or suspected of having coronary artery disease. The exercise test is an extremely safe procedure, with an event rate similar to other recent surveys. However, a great deal of variation exists in terms of criteria for abnormal results and whether physician presence is required during exercise testing. FAU - Myers, J AU - Myers J AD - VA Palo Alto Health Care System, CA 94304, USA. FAU - Voodi, L AU - Voodi L FAU - Umann, T AU - Umann T FAU - Froelicher, V F AU - Froelicher VF LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - J Cardiopulm Rehabil JT - Journal of cardiopulmonary rehabilitation JID - 8511296 RN - 0 (Sympathomimetics) RN - 3S12J47372 (Dobutamine) SB - IM MH - Coronary Disease/diagnosis MH - Dobutamine MH - Echocardiography MH - Electrocardiography MH - *Exercise Test/methods/standards/statistics & numerical data MH - Hospitals, Veterans MH - Humans MH - Practice Guidelines as Topic MH - Pulmonary Gas Exchange MH - Safety MH - Surveys and Questionnaires MH - Sympathomimetics MH - United States EDAT- 2000/08/24 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/08/24 11:00 PHST- 2000/08/24 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/08/24 11:00 [entrez] AID - 10.1097/00008483-200007000-00007 [doi] PST - ppublish SO - J Cardiopulm Rehabil. 2000 Jul-Aug;20(4):251-8. doi: 10.1097/00008483-200007000-00007. PMID- 21593026 OWN - NLM STAT- MEDLINE DCOM- 20120305 LR - 20211020 IS - 1742-5662 (Electronic) IS - 1742-5689 (Print) IS - 1742-5662 (Linking) VI - 8 IP - 65 DP - 2011 Dec 7 TI - Health safety nets can break cycles of poverty and disease: a stochastic ecological model. PG - 1796-803 LID - 10.1098/rsif.2011.0153 [doi] AB - The persistence of extreme poverty is increasingly attributed to dynamic interactions between biophysical processes and economics, though there remains a dearth of integrated theoretical frameworks that can inform policy. Here, we present a stochastic model of disease-driven poverty traps. Whereas deterministic models can result in poverty traps that can only be broken by substantial external changes to the initial conditions, in the stochastic model there is always some probability that a population will leave or enter a poverty trap. We show that a 'safety net', defined as an externally enforced minimum level of health or economic conditions, can guarantee ultimate escape from a poverty trap, even if the safety net is set within the basin of attraction of the poverty trap, and even if the safety net is only in the form of a public health measure. Whereas the deterministic model implies that small improvements in initial conditions near the poverty-trap equilibrium are futile, the stochastic model suggests that the impact of changes in the location of the safety net on the rate of development may be strongest near the poverty-trap equilibrium. FAU - Plucinski, Mateusz M AU - Plucinski MM AD - Division of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720, USA. FAU - Ngonghala, Calistus N AU - Ngonghala CN FAU - Bonds, Matthew H AU - Bonds MH LA - eng GR - K01 TW008773-01/TW/FIC NIH HHS/United States GR - K01 TW008773-03/TW/FIC NIH HHS/United States GR - K01 TW008773/TW/FIC NIH HHS/United States GR - K01 TW008773-02/TW/FIC NIH HHS/United States GR - K01TW008773/TW/FIC NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20110518 PL - England TA - J R Soc Interface JT - Journal of the Royal Society, Interface JID - 101217269 SB - IM MH - Computer Simulation MH - Delivery of Health Care/economics/*organization & administration MH - Ecology MH - Health MH - Health Services Research MH - Humans MH - Income MH - Models, Economic MH - Models, Theoretical MH - Population Dynamics MH - *Poverty MH - Probability MH - Public Health MH - Socioeconomic Factors MH - Stochastic Processes PMC - PMC3203484 EDAT- 2011/05/20 06:00 MHDA- 2012/03/06 06:00 PMCR- 2011/05/18 CRDT- 2011/05/20 06:00 PHST- 2011/05/20 06:00 [entrez] PHST- 2011/05/20 06:00 [pubmed] PHST- 2012/03/06 06:00 [medline] PHST- 2011/05/18 00:00 [pmc-release] AID - rsif.2011.0153 [pii] AID - rsif20110153 [pii] AID - 10.1098/rsif.2011.0153 [doi] PST - ppublish SO - J R Soc Interface. 2011 Dec 7;8(65):1796-803. doi: 10.1098/rsif.2011.0153. Epub 2011 May 18. PMID- 38257924 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241023 IS - 2076-2607 (Print) IS - 2076-2607 (Electronic) IS - 2076-2607 (Linking) VI - 12 IP - 1 DP - 2024 Jan 3 TI - Applications of Bacillus subtilis Protein Display for Medicine, Catalysis, Environmental Remediation, and Protein Engineering. LID - 10.3390/microorganisms12010097 [doi] LID - 97 AB - Bacillus subtilis spores offer several advantages that make them attractive for protein display. For example, protein folding issues associated with unfolded polypeptide chains crossing membranes are circumvented. In addition, they can withstand physical and chemical extremes such as heat, desiccation, radiation, ultraviolet light, and oxidizing agents. As a result, the sequence of the displayed protein can be easily obtained even under harsh screening conditions. Next, immobilized proteins have many economic and technological advantages. They can be easily separated from the reaction and the protein stability is increased in harsh environments. In traditional immobilization methods, proteins are expressed and purified and then they are attached to a matrix. In contrast, immobilization occurs naturally during the sporulation process. They can be easily separated from the reaction and the protein stability is increased in harsh environments. Spores are also amenable to high-throughput screening for protein engineering and optimization. Furthermore, they can be used in a wide array of biotechnological and industrial applications such as vaccines, bioabsorbants to remove toxic chemicals, whole-cell catalysts, bioremediation, and biosensors. Lastly, spores are easily produced in large quantities, have a good safety record, and can be used as additives in foods and drugs. FAU - Mahmoodi, Asieh AU - Mahmoodi A AD - New Jersey Institute of Technology, Newark, NJ 07102, USA. FAU - Farinas, Edgardo T AU - Farinas ET AUID- ORCID: 0000-0002-5514-9115 AD - New Jersey Institute of Technology, Newark, NJ 07102, USA. LA - eng PT - Journal Article PT - Review DEP - 20240103 PL - Switzerland TA - Microorganisms JT - Microorganisms JID - 101625893 PMC - PMC10821481 OTO - NOTNLM OT - Bacillus subtilis spore OT - enzyme activity OT - protein display OT - protein stability COIS- The authors declare no conflict of interest. EDAT- 2024/01/23 06:43 MHDA- 2024/01/23 06:44 PMCR- 2024/01/03 CRDT- 2024/01/23 01:23 PHST- 2023/12/05 00:00 [received] PHST- 2023/12/29 00:00 [revised] PHST- 2023/12/30 00:00 [accepted] PHST- 2024/01/23 06:44 [medline] PHST- 2024/01/23 06:43 [pubmed] PHST- 2024/01/23 01:23 [entrez] PHST- 2024/01/03 00:00 [pmc-release] AID - microorganisms12010097 [pii] AID - microorganisms-12-00097 [pii] AID - 10.3390/microorganisms12010097 [doi] PST - epublish SO - Microorganisms. 2024 Jan 3;12(1):97. doi: 10.3390/microorganisms12010097. PMID- 30835389 OWN - NLM STAT- MEDLINE DCOM- 20191105 LR - 20200225 IS - 2214-9996 (Electronic) IS - 2214-9996 (Linking) VI - 84 IP - 3 DP - 2018 Aug 31 TI - Thermal Exposure and Heat Illness Symptoms among Workers in Mara Gold Mine, Tanzania. PG - 360-368 LID - 10.29024/aogh.2318 [doi] AB - BACKGROUND: Working in a humid and hot environment creates challenges to occupational health and safety in tropical countries. Being in the region, Tanzania can experiences more than 30°C ambient temperature, which exposes miners to heat-related injury and illness. OBJECTIVES: This study was conducted to assess heat stress exposure and associated heat illness symptoms among gold mine workers in the Mara region. METHODS: A cross-sectional study was conducted among 60 miners from four Similar Exposure Groups based on risk to extreme heat environment. The WBGT index was used to assess the heat load while the miners' physiological condition explained the heat strain indicator. Data was analyzed using SPSS 20. Chi-square was used to differentiate proportion of miners with heat illness symptoms in different categories. Pearson correlation was used to determine association between environmental measures and change in physiological conditions of the miners. Independent t-test and ANOVA were used to assess differences between numerical data among groups. A p < 0.05 at 95% confidence was considered to be statistically significant. FINDINGS: The recorded average WBGT at the mining site was within the ACGIH TLV of 28.5°C, however, 78.4% of underground miners and 69.6% of open cut miners reported to have moderate heat illness. High body temperature and hot and dry skin were the most frequently reported heat illness symptoms. The mean core body temperatures of miners in open cut and underground were 38.4 ± 0.5°C and 37.3 ± 0.5°C respectively. Approximately 80% of miners in open cut indicated higher core body temperature above ISO 7933 threshold of 38.0°C for safety. The majority of workers under contract didn't drink water prior to work shift commencement. CONCLUSIONS: The occupational setting at the mining area presents the potential exposure to a thermal condition that can contribute to heat illness symptoms. Effective strategies must be implemented to enhance workers' safety. CI - © 2018 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. FAU - Meshi, E B AU - Meshi EB AD - Department of Public Health, College of Health and Allied Sciences, The University of Dodoma, Dodoma, TZ. FAU - Kishinhi, S S AU - Kishinhi SS AD - Department of Environmental and Occupational Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, TZ. FAU - Mamuya, S H AU - Mamuya SH AD - Department of Environmental and Occupational Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, TZ. FAU - Rusibamayila, M G AU - Rusibamayila MG AD - Department of Epidemiology, Dodoma Regional Referral Hospital, Dodoma, TZ. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180831 PL - United States TA - Ann Glob Health JT - Annals of global health JID - 101620864 RN - 7440-57-5 (Gold) SB - IM MH - Adult MH - Cross-Sectional Studies MH - Female MH - *Gold MH - Heat Stress Disorders/diagnosis/epidemiology/*etiology MH - Hot Temperature/*adverse effects MH - Humans MH - Male MH - Middle Aged MH - *Mining MH - Occupational Diseases/diagnosis/epidemiology/*etiology MH - Occupational Exposure/*adverse effects/statistics & numerical data MH - Tanzania/epidemiology PMC - PMC6748306 COIS- The authors have no competing interests to declare. EDAT- 2019/03/06 06:00 MHDA- 2019/11/07 06:00 PMCR- 2018/08/31 CRDT- 2019/03/06 06:00 PHST- 2019/03/06 06:00 [entrez] PHST- 2019/03/06 06:00 [pubmed] PHST- 2019/11/07 06:00 [medline] PHST- 2018/08/31 00:00 [pmc-release] AID - 10.29024/aogh.2318 [doi] PST - epublish SO - Ann Glob Health. 2018 Aug 31;84(3):360-368. doi: 10.29024/aogh.2318. PMID- 31025132 OWN - NLM STAT- MEDLINE DCOM- 20191212 LR - 20200225 IS - 1573-9686 (Electronic) IS - 0090-6964 (Print) IS - 0090-6964 (Linking) VI - 47 IP - 8 DP - 2019 Aug TI - Mechanical Safety of Embedded Electronics for In-body Wearables: A Smart Mouthguard Study. PG - 1725-1737 LID - 10.1007/s10439-019-02267-4 [doi] AB - The growing popularity of contact sports drives the requirement for better design of protective equipment, such as mouthguards. Smart mouthguards with embedded electronics provide a multitude of new ways to provide increased safety and protection to users. Characterisation of how electronic components embedded in typical mouthguard material, ethylene vinyl acetate (EVA), behave under typical sports impacts is crucial for future designs. A novel pendulum impact rig using a hockey ball disc impactor was developed to investigate impact forces and component failure. Two sets of dental models (aluminium and plastic padding chemical metal) were used to manufacture post-thermoformed mouthguards. Seven embedding conditions with varying thickness of EVA (1.5 and 3 mm) and locations of electrical components were tested. Component failures were observed in four out of seven test conditions, and the experimental failure forces at which the electrical component had a 50% chance of failure were reported for those cases. The experimental results showed that an EVA thickness of 3 mm surrounding the electrical component gives the most comprehensive protection even under extreme surface conformity. Computational models on surface conformity of EVA showed that a block of EVA with a minimum thickness of 1.5 mm was better at reducing stress concentration than a shell with an overall thickness of 1.5 mm. This study demonstrated that the thickness of a mouthguard is important when protecting electrical components from extreme dental surface conformity, furthermore the surface geometry should not be overlooked when considering electrical component safety for in-body wearables that are impact prone. FAU - Bridgman, Helen AU - Bridgman H AD - Natural Interactions Lab, Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. FAU - Kwong, Man Ting AU - Kwong MT AD - Natural Interactions Lab, Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. FAU - Bergmann, Jeroen H M AU - Bergmann JHM AUID- ORCID: 0000-0001-7306-2630 AD - Natural Interactions Lab, Oxford Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. jeroen.bergmann@eng.ox.ac.uk. LA - eng GR - EP/R511742/1/Engineering and Physical Sciences Research Council/ PT - Journal Article DEP - 20190425 PL - United States TA - Ann Biomed Eng JT - Annals of biomedical engineering JID - 0361512 RN - 0 (Polyvinyls) RN - 24937-78-8 (ethylenevinylacetate copolymer) SB - IM MH - Computer Simulation MH - *Equipment Design MH - Materials Testing MH - *Mouth Protectors MH - Polyvinyls MH - *Sports Equipment MH - *Wearable Electronic Devices PMC - PMC6647539 OTO - NOTNLM OT - Embedded electronics OT - FEM OT - Impact OT - Mechanical assessment OT - Thermoformed EDAT- 2019/04/27 06:00 MHDA- 2019/12/18 06:00 PMCR- 2019/04/25 CRDT- 2019/04/27 06:00 PHST- 2019/01/12 00:00 [received] PHST- 2019/04/06 00:00 [accepted] PHST- 2019/04/27 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/04/27 06:00 [entrez] PHST- 2019/04/25 00:00 [pmc-release] AID - 10.1007/s10439-019-02267-4 [pii] AID - 2267 [pii] AID - 10.1007/s10439-019-02267-4 [doi] PST - ppublish SO - Ann Biomed Eng. 2019 Aug;47(8):1725-1737. doi: 10.1007/s10439-019-02267-4. Epub 2019 Apr 25. PMID- 28329929 OWN - NLM STAT- MEDLINE DCOM- 20170904 LR - 20231213 IS - 0254-6450 (Print) IS - 0254-6450 (Linking) VI - 38 IP - 3 DP - 2017 Mar 10 TI - [Influence of extreme weather on years of life lost due to diabetes death in Chongqing and Harbin, China]. PG - 303-308 LID - 10.3760/cma.j.issn.0254-6450.2017.03.006 [doi] AB - Objective: To understand the associations between extremely low and high air temperature and the years of life lost (YLL) due to diabetes deaths in Chongqing and Harbin with different climatic characteristics in China. Methods: A double threshold B-spline distributed lag non-linear model (DLNM) was used to investigate the lag and cumulative effects of extremely low and high air temperature on YLL due to diabetes for lag 0-30 days by using the urban meteorological and diabetes mortality data of Chongqing (2011-2013) and Harbin (2008-2010). The effects were expressed as relative risk (RR). Results: In Chongqing, the cold effects on YLL due to diabetes were delayed by four days and lasted for three days (lag4-6) with the highest RR of 1.304 (95%CI:1.033-1.647) at lag5. The hot effects were delayed by one day (lag1) with RR of 1.321 (95%CI:1.061-1.646). In Harbin, the extreme cold effects on YLL were delayed by four days and lasted for seven days (lag4-10) with the highest RR of 1.309 (95%CI: 1.088-1.575) at lag6. The hot effects were delayed by one day and lasted for four days (lag1-4) with the highest RR of 1.460 (95%CI:1.114-1.915) at lag2. The unit risk for cold and hot effects was 43.7% (P=0.005 5) and 18.0% (P=0.000 2) in Chongqing and 15.0% (P=0.000 8) and 29.5% (P=0.001 2) in Harbin, respectively. Conclusions: Both extremely low air temperature and extremely high air temperature might increase the years of life lost due to diabetes in cities with different climate characteristics. Health education about diabetes prevention should provide information about the effects of extreme weather events. FAU - Li, Y H AU - Li YH AD - Division of Policy, Regulation and Standard, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Luo, S Q AU - Luo SQ AD - Public Health and Safety Monitoring Department, Chongqing Municipal Center for Disease Control and Prevention, Chongqing 404000, China. FAU - Lan, L AU - Lan L AD - Division of Chronic Disease Control and Prevention, Harbin Municipal Center for Disease Control and Prevention, Harbin 150056, China. FAU - Jin, M G AU - Jin MG AD - Qijiang District Center for Disease Control and Prevention of Chongqing, Chongqing 401420, China. FAU - Yang, C AU - Yang C AD - Harbin Municipal Center for Disease Control and Prevention, Harbin 150056, China. FAU - He, J Y AU - He JY AD - Public Health and Safety Monitoring Department, Chongqing Municipal Center for Disease Control and Prevention, Chongqing 404000, China. FAU - Li, H B AU - Li HB AD - Public Health and Monitoring Center, Harbin Municipal Center for Disease Control and Prevention, Harbin 150056, China. FAU - Li, C C AU - Li CC AD - Environmental Epidemiology Department, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Cheng, Y B AU - Cheng YB AD - Division of Policy, Regulation and Standard, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Jin, Y L AU - Jin YL AD - Division of Policy, Regulation and Standard, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. LA - chi PT - Journal Article PL - China TA - Zhonghua Liu Xing Bing Xue Za Zhi JT - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JID - 8208604 SB - IM MH - China/epidemiology MH - Cities MH - Climate Change MH - *Cold Temperature/adverse effects MH - Diabetes Mellitus/*mortality MH - Extreme Cold MH - *Hot Temperature/adverse effects MH - Humans MH - Life Expectancy/*trends MH - Mortality/*trends MH - Nonlinear Dynamics MH - Risk Factors MH - Urban Population MH - *Weather OTO - NOTNLM OT - Climate change OT - Diabetes mellitus OT - Extreme temperature effects OT - Life OT - Temperature OT - Years of life lost EDAT- 2017/03/23 06:00 MHDA- 2017/09/05 06:00 CRDT- 2017/03/23 06:00 PHST- 2017/03/23 06:00 [entrez] PHST- 2017/03/23 06:00 [pubmed] PHST- 2017/09/05 06:00 [medline] AID - 10.3760/cma.j.issn.0254-6450.2017.03.006 [doi] PST - ppublish SO - Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Mar 10;38(3):303-308. doi: 10.3760/cma.j.issn.0254-6450.2017.03.006. PMID- 39465135 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241029 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 11 DP - 2024 TI - Combined endovascular interventions for pulmonary embolism at high altitude in Tibet. PG - 1384930 LID - 10.3389/fcvm.2024.1384930 [doi] LID - 1384930 AB - BACKGROUND: Managing pulmonary embolism (PE) at extremely high altitudes poses unique challenges due to harsh environmental conditions and limited healthcare resources. METHOD: This study retrospectively analyzed Tibetan PE patients in the Tibet Autonomous Region of China to evaluate the effectiveness and safety of combined endovascular interventional therapy in high-altitude areas. RESULTS: The average altitude of long-term residence for Tibetan patients was 3,863.4 ± 317.4 m, with an average age of 62.0 ± 16.0 years, and the time from computed tomography pulmonary angiography (CTPA) diagnosis to interventional treatment averaged 2.8 ± 2.2 days. The operation time for these patients was 106.1 ± 22.2 min, and the intraoperative dose of alteplase used was 23.3 ± 5.0 mg. All 9 patients reported profound remission of dyspnea and chest pain after endovascular interventions. The heart rate (p < 0.05) and respiratory rate (p < 0.001) of all enrolled patients were significantly decreased, and the peripheral capillary oxygen saturation (SpO2) was significantly increased (p < 0.05) after interventions. No severe complications, such as bleeding, occurred in any patient. CONCLUSION: This study demonstrated the potential clinical benefits and feasibility of combined endovascular interventional therapy for treating acute PE in extreme high-altitude regions. CI - © 2024 Yang and Yang. FAU - Yang, Tengyan AU - Yang T AD - Respiratory Department, Changdu People's Hospital of Xizang, Changdu, China. FAU - Yang, Jian AU - Yang J AD - Gastroenterology Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. LA - eng PT - Journal Article DEP - 20241011 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC11502403 OTO - NOTNLM OT - effectiveness OT - endovascular intervention OT - high altitude OT - pulmonary embolism OT - safety, Tibet COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/28 06:22 MHDA- 2024/10/28 06:23 PMCR- 2024/01/01 CRDT- 2024/10/28 05:28 PHST- 2024/02/22 00:00 [received] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/10/28 06:23 [medline] PHST- 2024/10/28 06:22 [pubmed] PHST- 2024/10/28 05:28 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2024.1384930 [doi] PST - epublish SO - Front Cardiovasc Med. 2024 Oct 11;11:1384930. doi: 10.3389/fcvm.2024.1384930. eCollection 2024. PMID- 10656300 OWN - NLM STAT- MEDLINE DCOM- 20000315 LR - 20240109 IS - 0891-5849 (Print) IS - 0891-5849 (Linking) VI - 28 IP - 1 DP - 2000 Jan 1 TI - Vitamin E and heart disease: basic science to clinical intervention trials. PG - 141-64 AB - A review is presented of studies on the effects of vitamin E on heart disease, studies encompassing basic science, animal studies, epidemiological and observational studies, and four intervention trials. The in vitro, cellular, and animal studies, which are impressive both in quantity and quality, leave no doubt that vitamin E, the most important fat-soluble antioxidant, protects animals against a variety of types of oxidative stress. The hypothesis that links vitamin E to the prevention of cardiovascular disease (CVD) postulates that the oxidation of unsaturated lipids in the low-density lipoprotein (LDL) particle initiates a complex sequence of events that leads to the development of atherosclerotic plaque. This hypothesis is supported by numerous studies in vitro, in animals, and in humans. There is some evidence that the ex vivo oxidizability of a subject's LDL is predictive of future heart events. This background in basic science and observational studies, coupled with the safety of vitamin E, led to the initiation of clinical intervention trials. The three trials that have been reported in detail are, on balance, supportive of the proposal that supplemental vitamin E can reduce the risk for heart disease, and the fourth trial, which has just been reported, showed small, but not statistically significant, benefits. Subgroup analyses of cohorts from the older three trials, as well as evidence from smaller trials, indicate that vitamin E provides protection against a number of medical conditions, including some that are indicative of atherosclerosis (such as intermittent claudication). Vitamin E supplementation also produces an improvement in the immune system and protection against diseases other than cardiovascular disease (such as prostate cancer). Vitamin E at the supplemental levels being used in the current trials, 100 to 800 IU/d, is safe, and there is little likelihood that increased risk will be found for those taking supplements. About one half of American cardiologists take supplemental vitamin E, about the same number as take aspirin. In fact, one study suggests that aspirin plus vitamin E is more effective than aspirin alone. There are a substantial number of trials involving vitamin E that are in progress. However, it is possible, or even likely, that each condition for which vitamin E provides benefit will have a unique dose-effect curve. Furthermore, different antioxidants appear to act synergistically, so supplementation with vitamin E might be more effective if combined with other micronutrients. It will be extremely difficult to do trials that adequately probe the dose-effect curve for vitamin E for each condition that it might affect, or to do studies of all the possible combinations of other micronutrients that might act with vitamin E to improve its effectiveness. Therefore, the scientific community must recognize that there never will be a time when the science is "complete." At some point, the weight of the scientific evidence must be judged adequate; although some may regard it as early to that judgement now, clearly we are very close. In view of the very low risk of reasonable supplementation with vitamin E, and the difficulty in obtaining more than about 30 IU/day from a balanced diet, some supplementation appears prudent now. FAU - Pryor, W A AU - Pryor WA AD - The Biodynamics Institute, Louisiana State University, Baton Rouge 70803, USA. wpryor@LSU.edu LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - United States TA - Free Radic Biol Med JT - Free radical biology & medicine JID - 8709159 RN - 0 (Antioxidants) RN - 0 (Biomarkers) RN - 0 (Free Radicals) RN - 0 (Lipoproteins, LDL) RN - 0 (Vitamins) RN - 0 (oxidized low density lipoprotein) RN - 1406-18-4 (Vitamin E) SB - IM MH - Adult MH - Aged MH - Angiography MH - Animals MH - Antioxidants/administration & dosage/*therapeutic use MH - Biomarkers MH - Cardiovascular Diseases/epidemiology/metabolism/*prevention & control MH - Case-Control Studies MH - Clinical Trials as Topic MH - Cohort Studies MH - Diet, Atherogenic MH - Double-Blind Method MH - Drug Synergism MH - Female MH - Free Radicals MH - Humans MH - Lipid Peroxidation MH - Lipoproteins, LDL/blood/metabolism MH - Male MH - Middle Aged MH - Oxidation-Reduction MH - Oxidative Stress MH - Prospective Studies MH - Rabbits MH - Randomized Controlled Trials as Topic MH - Risk MH - Safety MH - Stroke/prevention & control MH - Vitamin E/administration & dosage/*therapeutic use MH - Vitamins/administration & dosage/pharmacology RF - 244 EDAT- 2000/02/03 09:00 MHDA- 2000/03/18 09:00 CRDT- 2000/02/03 09:00 PHST- 2000/02/03 09:00 [pubmed] PHST- 2000/03/18 09:00 [medline] PHST- 2000/02/03 09:00 [entrez] AID - S0891-5849(99)00224-5 [pii] AID - 10.1016/s0891-5849(99)00224-5 [doi] PST - ppublish SO - Free Radic Biol Med. 2000 Jan 1;28(1):141-64. doi: 10.1016/s0891-5849(99)00224-5. PMID- 11363612 OWN - NLM STAT- MEDLINE DCOM- 19960711 LR - 20041117 IS - 1523-2883 (Print) IS - 1523-2883 (Linking) VI - 7 IP - 4 DP - 1996 Jul-Aug TI - Waste not. PG - 24-5 FAU - McGuire, S AU - McGuire S LA - eng PT - Journal Article PT - Newspaper Article PL - United States TA - Posit Aware JT - Positively aware : the monthly journal of the Test Positive Aware Network JID - 9413754 MH - Cachexia/*complications/prevention & control/therapy MH - HIV Infections/*complications MH - Humans OAB - Wasting, a condition characterized by extreme loss of body tissue and lean muscle mass, should never be allowed to occur. Generally defined as weight loss of 10 percent, it is now being redefined as an unintended weight loss accompanied by fever, weakness or diarrhea lasting more than 30 days. This definition is important because wasting is invisible in its early stages. Patients may gain fat while losing muscle, giving them a stable appearance. However, muscle tissue is where most metabolic processes take place. Wasting can be detected early through a bioelectrical impedance analysis (BIA) test. A checklist is included to determine the level of nutritional risk, and safety tips for shopping and preparing foods are provided. Patients are cautioned to never eat foods containing raw meat, fish, or poultry, and to avoid foods with raw eggs. OABL- eng EDAT- 1996/07/01 00:00 MHDA- 2001/05/22 10:01 CRDT- 1996/07/01 00:00 PHST- 1996/07/01 00:00 [pubmed] PHST- 2001/05/22 10:01 [medline] PHST- 1996/07/01 00:00 [entrez] PST - ppublish SO - Posit Aware. 1996 Jul-Aug;7(4):24-5. PMID- 21874970 OWN - NLM STAT- MEDLINE DCOM- 20110930 LR - 20220316 IS - 1553-7250 (Print) IS - 1553-7250 (Linking) VI - 37 IP - 8 DP - 2011 Aug TI - On the front lines of patient safety: implementation and evaluation of team training in Iraq. PG - 350-6 AB - BACKGROUND: Team training has been identified as a key strategy for reducing medical errors and building a culture of safety in health care. Communication and coordination skills can serve as barriers to potential errors, as in the modern deployed U.S. Military Healthcare System (MHS), which emphasizes rapid movement of critically injured patients to facilities capable of providing definitive care. A team training intervention--TeamSTEPPS--was implemented on a large scale during one of the most intense phases of the conflict in Iraq. This evaluation of the program constituted the first undertaken in a combat theater of operations. IMPLEMENTING TEAMSTEPPS IN IRAQ: The Baghdad combat support hospital (CSH) conducted continuous operations from a fixed facility for a 13-month deployment--between November 2007 and December 2008. The TeamSTEPPS implementation in Iraq began at this facility and spread throughout the combat theater of operations. Teamwork training was implemented in two primary training sessions, followed up with reinforcement of team behaviors on the unit by hospital leadership. RESULTS: A total of 153 patient safety reports were submitted during the 13 months reviewed, 94 before TeamSTEPPS implementation and 59 afterwards. After training, there were significant decreases in the rates of communication-related errors, medication and transfusion errors, and needlestick incidents. There was a significant decrease in the rate of incidents coded communication as the primary teamwork skill that could have potentially prevented the event. CONCLUSIONS: Process improvement programs such as TeamSTEPPS implementation can be conducted under the extremely austere conditions of a CSH in a combat zone. Teamwork training decreased medical errors in the CSH while deployed in the combat theater in Iraq. FAU - Deering, Shad AU - Deering S AD - Andersen Simulation Center, Madigan Army Medical Center, Tacoma, Washington, USA. Shad.deering@us.army.mil FAU - Rosen, Michael A AU - Rosen MA FAU - Ludi, Vivian AU - Ludi V FAU - Munroe, Michelle AU - Munroe M FAU - Pocrnich, Amber AU - Pocrnich A FAU - Laky, Christine AU - Laky C FAU - Napolitano, Peter G AU - Napolitano PG LA - eng PT - Journal Article PL - Netherlands TA - Jt Comm J Qual Patient Saf JT - Joint Commission journal on quality and patient safety JID - 101238023 SB - IM MH - Humans MH - Interdisciplinary Communication MH - Iraq War, 2003-2011 MH - Medical Errors/*prevention & control/statistics & numerical data MH - Military Medicine/organization & administration/*standards MH - Military Personnel/*education MH - Patient Care Team/organization & administration/*standards MH - Safety Management/organization & administration/*standards/statistics & numerical data MH - United States EDAT- 2011/08/31 06:00 MHDA- 2011/10/01 06:00 CRDT- 2011/08/31 06:00 PHST- 2011/08/31 06:00 [entrez] PHST- 2011/08/31 06:00 [pubmed] PHST- 2011/10/01 06:00 [medline] AID - S1553-7250(11)37045-6 [pii] AID - 10.1016/s1553-7250(11)37045-6 [doi] PST - ppublish SO - Jt Comm J Qual Patient Saf. 2011 Aug;37(8):350-6. doi: 10.1016/s1553-7250(11)37045-6. PMID- 26803090 OWN - NLM STAT- MEDLINE DCOM- 20161214 LR - 20161230 IS - 1539-2880 (Electronic) IS - 0730-0832 (Linking) VI - 34 IP - 2 DP - 2015 TI - Probiotics for Preterm Infants: A Premature or Overdue Necrotizing Enterocolitis Prevention Strategy? PG - 83-101 LID - 10.1891/0730-0832.34.2.83 [doi] AB - Common among preterm, very low birth weight (VLBW) and extremely low birth weight (ELBW) infants, necrotizing enterocolitis (NEC) is a gastrointestinal, infectious disease that remains a leading cause of morbidity and mortality among this high-risk population. To combat this devastating condition, research efforts have been redirected from treatment toward prevention strategies. Although there are several proposed risk-reduction strategies, one intervention gaining support is the administration of prophylactic enteral probiotics. Regardless of growing evidentiary support and a benign safety profile, neonatal providers have yet to embrace this therapy. This article provides an overview of the proposed benefits of probiotics, focusing on their role as a NEC prevention strategy. A review of several sentinel research studies targeting preterm, VLBW, and ELBW infants is provided. Considerations for ongoing research are reviewed. Finally, two evidence-based NEC prevention probiotics protocols are presented. FAU - Anderson, Sharon AU - Anderson S LA - eng PT - Journal Article PT - Review PL - United States TA - Neonatal Netw JT - Neonatal network : NN JID - 8503921 MH - Dietary Supplements MH - *Enterocolitis, Necrotizing/etiology/microbiology/physiopathology/prevention & control MH - Humans MH - Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Infant, Premature MH - Probiotics/*therapeutic use MH - Treatment Outcome EDAT- 2016/01/24 06:00 MHDA- 2016/12/15 06:00 CRDT- 2016/01/24 06:00 PHST- 2016/01/24 06:00 [entrez] PHST- 2016/01/24 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - 10.1891/0730-0832.34.2.83 [doi] PST - ppublish SO - Neonatal Netw. 2015;34(2):83-101. doi: 10.1891/0730-0832.34.2.83. PMID- 38233490 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240121 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jan 17 TI - Artificial neural network analysis for classification of defected high voltage ceramic insulators. PG - 1513 LID - 10.1038/s41598-024-51860-8 [doi] LID - 1513 AB - Partial discharge (PD) could lead to the formation of small arcs or sparks within the insulating material, which can cause damage and degradation to the insulator over time. In ceramic insulators, there are several factors that can cause PD including manufacturing defects, aging, and exposure to environmental conditions such as moisture and temperature extremes. As a result, detecting and monitoring PD in ceramic insulators is important for ensuring the reliability and safety of electrical systems that rely on these insulators. In this study, acoustic emission technique is introduced for PD detection and condition monitoring of defective ceramic insulators. A sequence of data processing techniques is performed on the captured signals to extract and select the most significant signatures for classification of defects in insulator strings. Artificial neural network (ANN) has been used to build an intelligent classifier for easily and accurately classification of defective insulators. The overall recognition rate of the classifier was obtained at 96.03% from discrete wavelet transform analysis and 88.65% from fast Fourier transform analysis. This obtained result indicates high accuracy and performance classification. The outcomes of ANN were verified by SVM and KNN algorithms. CI - © 2024. The Author(s). FAU - Haiba, Ahmed S AU - Haiba AS AD - Electrical Metrology Division, National Institute of Standards (NIS), Giza, Egypt. ahmed.haiba@nis.sci.eg. FAU - Eliwa Gad, A AU - Eliwa Gad A AD - Electrical Metrology Division, National Institute of Standards (NIS), Giza, Egypt. LA - eng PT - Journal Article DEP - 20240117 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC10794418 COIS- The authors declare no competing interests. EDAT- 2024/01/18 00:42 MHDA- 2024/01/18 00:43 PMCR- 2024/01/17 CRDT- 2024/01/17 23:19 PHST- 2023/09/26 00:00 [received] PHST- 2024/01/10 00:00 [accepted] PHST- 2024/01/18 00:43 [medline] PHST- 2024/01/18 00:42 [pubmed] PHST- 2024/01/17 23:19 [entrez] PHST- 2024/01/17 00:00 [pmc-release] AID - 10.1038/s41598-024-51860-8 [pii] AID - 51860 [pii] AID - 10.1038/s41598-024-51860-8 [doi] PST - epublish SO - Sci Rep. 2024 Jan 17;14(1):1513. doi: 10.1038/s41598-024-51860-8. PMID- 9836789 OWN - NLM STAT- MEDLINE DCOM- 19990209 LR - 20131121 IS - 1076-3279 (Print) IS - 1076-3279 (Linking) VI - 4 IP - 3 DP - 1998 Fall TI - Voluntary guidance for the development of tissue-engineered products. PG - 239-66 AB - Tissue Engineering is an emerging field of medical research in which there is tremendous activity. Many of these products rely on the use of a cellular component co-formulated with a natural or synthetic biomaterial. At this time, though, there are no consensus safety or efficacy standards for tissue-engineered products. We describe general approaches for assessment of the safety and efficacy of cell-based tissue-engineered products which will lead to reliable medical products for human use. This article provides a general summary of the factors that should be considered in the design and development of cell- and tissue-based products. Seven areas are considered: cell and tissue sourcing; cell and tissue characterization; biomaterials testing; quality assurance; quality control; and nonclinical testing and clinical evaluation. Factors relevant to these areas have been discussed to provide a set of recommendations on which development of products can be standardized. Where relevant, the discussion has been separated in each area to issues that are independent or dependent on cell source. Also, examples are provided of how these guidelines would be applied to two product types that represent somewhat extreme ends of the spectrum for tissue engineering applications. The first example is a product whose mechanism of action is to provide locally-acting structural repair or enhancement in vivo. The second example is a product whose mechanism of action involves systemically distributed physiologically or pharmacologically active products. In general, we have limited the discussion of product types to those that are implanted into the patient for relatively long periods of time. We believe that adoption of these voluntary guidelines would lead to products that are more consistent in quality and performance as well as more rapidly developed. FAU - Omstead, D R AU - Omstead DR AD - Reprogenesis, Inc., Cambridge, Massachusetts, USA. FAU - Baird, L G AU - Baird LG FAU - Christenson, L AU - Christenson L FAU - Du Moulin, G AU - Du Moulin G FAU - Tubo, R AU - Tubo R FAU - Maxted, D D AU - Maxted DD FAU - Davis, J AU - Davis J FAU - Gentile, F T AU - Gentile FT LA - eng PT - Journal Article PT - Review PL - United States TA - Tissue Eng JT - Tissue engineering JID - 9505538 RN - 0 (Biocompatible Materials) RN - 0 (Biological Products) SB - IM MH - Animals MH - Artificial Organs/standards MH - Biocompatible Materials/standards MH - Biological Products/standards MH - Biomedical Engineering/organization & administration/*standards MH - Bioprosthesis/*standards MH - Cells, Cultured MH - Clinical Trials as Topic/methods MH - Communicable Disease Control MH - Female MH - Humans MH - Male MH - Materials Testing MH - Prostheses and Implants/*standards MH - Prosthesis Design MH - Quality Assurance, Health Care MH - Quality Control MH - Safety MH - Tissue Donors MH - Transplantation, Heterologous MH - Transplantation, Homologous RF - 55 EDAT- 1998/12/04 00:00 MHDA- 1998/12/04 00:01 CRDT- 1998/12/04 00:00 PHST- 1998/12/04 00:00 [pubmed] PHST- 1998/12/04 00:01 [medline] PHST- 1998/12/04 00:00 [entrez] AID - 10.1089/ten.1998.4.239 [doi] PST - ppublish SO - Tissue Eng. 1998 Fall;4(3):239-66. doi: 10.1089/ten.1998.4.239. PMID- 35956231 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 15 DP - 2022 Aug 8 TI - Mental Health Condition among University Students of Bangladesh during the Critical COVID-19 Period. LID - 10.3390/jcm11154617 [doi] LID - 4617 AB - Bangladesh's education sector has been in a state of flux since COVID-19. During the pandemic, all university campuses were closed. There was a mental health issue among the students. This study aims to examine the mental health condition and the determinants that contribute to adverse mental health conditions among university students of Bangladesh. A survey was performed online among university students in Bangladesh, in mid-June 2020 when averaging 3345 affected cases of the population daily. The convenience sampling technique was used and the survey gathered data from 365 university students. The relationship between general information and Depression, Anxiety, and Stress Scale 21 (DASS-21) subscales of university students was determined. The questionnaire was administered to respondents during the pandemic, which ensured fast replies. Linear regression models were used for statistical analysis. University students indicated normal levels of depression (30.41%), anxiety (43.29%), and stress (47.40%). However, a disproportionate number of extremely depressed, anxious, and stressed university students suggested a mental health status of concern. There were significant connections between the individual's opinion of social satisfaction, mental health concerns, and the present location's safety with an undesirable mental health condition. Female students were shown to be much more anxious and stressed than male students. Capital Dhaka city students were more depressed and anxious than students outside of Dhaka. Financial and psychological support for students may help mitigate the psychological impact. Authorities should make effective efforts to reduce mental health problems among these students. This research may aid organizations, health care providers, and social workers in their attempts to prepare for and respond to pandemics. FAU - Rahman, Md Mostafizur AU - Rahman MM AUID- ORCID: 0000-0002-0732-9437 AD - Department of Disaster Management and Resilience, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Asikunnaby AU - Asikunnaby AD - Department of Disaster Management and Resilience, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Khan, Saadmaan Jubayer AU - Khan SJ AD - Department of Disaster Management and Resilience, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Arony, Anuva AU - Arony A AD - Department of Disaster and Human Security Management, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Mamun, Zahid Al AU - Mamun ZA AD - Department of Disaster and Human Security Management, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Procheta, Nawwar Fatima AU - Procheta NF AD - Department of Disaster and Human Security Management, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Sakib, Mohammed Sadman AU - Sakib MS AD - Department of Disaster and Human Security Management, Faculty of Arts and Social Sciences, Bangladesh University of Professionals, Mirpur Cantonment, Dhaka 1216, Bangladesh. FAU - Aryal, Komal Raj AU - Aryal KR AUID- ORCID: 0000-0001-9980-4516 AD - Crisis and Disaster Management, Aston Business School, Aston University, Birmingham B4 7ET, UK. FAU - Rahman, Farzana AU - Rahman F AD - Department of Computer Science and Engineering, Independent University, Dhaka 1212, Bangladesh. FAU - Islam, Abu Reza Md Towfiqul AU - Islam ARMT AUID- ORCID: 0000-0001-5779-1382 AD - Department of Disaster Management, Begum Rokeya University, Rangpur 5400, Bangladesh. LA - eng PT - Journal Article DEP - 20220808 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9369879 OTO - NOTNLM OT - COVID-19 OT - lockdown OT - mental health OT - stress OT - tertiary education OT - university students COIS- The authors declare no conflict of interest. EDAT- 2022/08/13 06:00 MHDA- 2022/08/13 06:01 PMCR- 2022/08/08 CRDT- 2022/08/12 01:16 PHST- 2022/07/13 00:00 [received] PHST- 2022/08/04 00:00 [revised] PHST- 2022/08/05 00:00 [accepted] PHST- 2022/08/12 01:16 [entrez] PHST- 2022/08/13 06:00 [pubmed] PHST- 2022/08/13 06:01 [medline] PHST- 2022/08/08 00:00 [pmc-release] AID - jcm11154617 [pii] AID - jcm-11-04617 [pii] AID - 10.3390/jcm11154617 [doi] PST - epublish SO - J Clin Med. 2022 Aug 8;11(15):4617. doi: 10.3390/jcm11154617. PMID- 26036104 OWN - NLM STAT- MEDLINE DCOM- 20150716 LR - 20150603 IS - 1210-7778 (Print) IS - 1210-7778 (Linking) VI - 23 IP - 1 DP - 2015 Mar TI - Prevention of taxi accidents in Xi'an, China: what matters most? PG - 77-83 AB - OBJECTIVES: Since the city of Xi'an has been extremely concerned with the serious problem of taxi involved crashes, injuries and fatalities, the primary purpose of this study is to identify the risk factors associated with the magnitude and nature of the problem and provide possible measures for enhancing the overall safety performance of taxi industry. METHODS: Using 726 crash samples from the original of 7,183 observations in Xi'an over the period from 2006 to 2012, comparative statistics and systematic analysis were employed to describe the distribution of taxi crashes by driver characteristics, roadway contributors and environmental factors and then determine the significant factors contributing to crash injuries and fatalities. RESULTS: The trend and pattern of taxi involved crashes vary significantly. Middle aged (77.27%) male (91.60%) drivers with limited education (68.59%) and less driving (31.27%) and job (82.50%) experience were much more likely to be involved in such a crash. Additionally, it is found that a large majority of taxi crashes occurred with the most frequent type of rear end collisions (30.72%), on six-lane segments without median (16.94%) or four legged intersections (15.29%), under adverse weather conditions (31.82%), at weekends (34.99%), and during winter days (34.72%), but fatal and serious crashes were more likely to happen at night (30.72%) or under wet road surface conditions (16.94%), due to driver's overspeeding, unbelted, disregarding signs or signals, or other types of risk driving behaviour. CONCLUSIONS: The risk of taxi related crashes varies by drivers, roadways and environment. To reduce the risk of potential crashes for taxi drivers, we recommend the targeted legislation and enforcement, stronger night and trip restrictions, awareness of risk behaviour, and periodical training requirement. Such proposals and measures are expected to help mitigate taxi crashes and promote road safety in China. FAU - Wang, Yonggang AU - Wang Y FAU - Li, Ming AU - Li M FAU - Du, Jianhua AU - Du J FAU - Mao, Chengyuan AU - Mao C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Czech Republic TA - Cent Eur J Public Health JT - Central European journal of public health JID - 9417324 SB - IM MH - Accidents, Traffic/*prevention & control/trends MH - Adolescent MH - Adult MH - Behavior MH - China MH - Female MH - Humans MH - Male MH - Middle Aged MH - Risk Factors MH - Safety MH - Statistics as Topic MH - *Transportation MH - Young Adult EDAT- 2015/06/04 06:00 MHDA- 2015/07/17 06:00 CRDT- 2015/06/04 06:00 PHST- 2015/06/04 06:00 [entrez] PHST- 2015/06/04 06:00 [pubmed] PHST- 2015/07/17 06:00 [medline] AID - 10.21101/cejph.a3931 [doi] PST - ppublish SO - Cent Eur J Public Health. 2015 Mar;23(1):77-83. doi: 10.21101/cejph.a3931. PMID- 39329170 OWN - NLM STAT- MEDLINE DCOM- 20241031 LR - 20250108 IS - 1473-6322 (Electronic) IS - 1473-6322 (Linking) VI - 24 IP - 6 DP - 2024 Dec 1 TI - Allergen-specific immunotherapy at the extremes of age: below 5 years and elderly: evidence beyond indications? PG - 510-519 LID - 10.1097/ACI.0000000000001030 [doi] AB - PURPOSE OF REVIEW: Allergen-specific immunotherapy (AIT) has been used in clinical practice to treat allergic diseases for over 100 years. The effectiveness and safety of AIT have been substantiated in numerous studies; however, children before 5 years of age and elderly are not encompassed generally. This review aims to present the current understanding of AIT in the extremes of age. RECENT FINDINGS: Early allergen immunotherapy during infancy or early childhood may prevent the development of allergic sensitization to common allergens, thereby reducing the risk of developing allergic diseases later in life. In the elderly, improved symptoms and quality of life and reduced dependence on medication are indicated the importance on the implementation of AIT. Both clinical and immunological parameters demonstrated that the treatment was effective at the time of cessation and trend to sustained tolerance. SUMMARY: There is no specific lower or upper age limit for initiating immunotherapy; however, it is important to thoroughly evaluate the severity of disease and the risks and benefits in each case. CI - Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. FAU - Özdemiral, Cansu AU - Özdemiral C AD - Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey. FAU - Gurel, Deniz Ilgun AU - Gurel DI FAU - Sahiner, Umit AU - Sahiner U LA - eng PT - Journal Article PT - Review DEP - 20240919 PL - United States TA - Curr Opin Allergy Clin Immunol JT - Current opinion in allergy and clinical immunology JID - 100936359 RN - 0 (Allergens) SB - IM MH - Humans MH - *Desensitization, Immunologic/methods MH - *Allergens/immunology/administration & dosage MH - *Hypersensitivity/immunology/therapy MH - Child, Preschool MH - Age Factors MH - Aged MH - Quality of Life MH - Infant MH - Immune Tolerance EDAT- 2024/09/27 07:05 MHDA- 2024/10/31 12:28 CRDT- 2024/09/27 05:39 PHST- 2024/10/31 12:28 [medline] PHST- 2024/09/27 07:05 [pubmed] PHST- 2024/09/27 05:39 [entrez] AID - 00130832-202412000-00013 [pii] AID - 10.1097/ACI.0000000000001030 [doi] PST - ppublish SO - Curr Opin Allergy Clin Immunol. 2024 Dec 1;24(6):510-519. doi: 10.1097/ACI.0000000000001030. Epub 2024 Sep 19. PMID- 23748397 OWN - NLM STAT- MEDLINE DCOM- 20140225 LR - 20130610 IS - 1172-6156 (Electronic) IS - 1172-6156 (Linking) VI - 5 IP - 2 DP - 2013 Jun 1 TI - Personal medicines storage in New Zealand. PG - 146-50 AB - INTRODUCTION: Poor storage of medicines can reduce their efficacy, yet little is known about how people store medicines in their homes and elsewhere, why these locations are chosen, and whether the conditions are suitable for medicines storage. AIM: To investigate where medicines are commonly stored in New Zealand households, why, and the typical conditions-temperature and relative humidity-in those places of storage. METHODS: Data from a large qualitative study on the meanings of medicines were analysed to explore where people store medicines in their households, and why. A data logger was used to log temperature and relative humidity in common medicine storage places, such as homes and cars. RESULTS: Kitchens and bathrooms were the most commonly reported storage places, with people influenced by convenience, desire to remember to take medicines, and child safety when deciding where to store medicines. High temperatures and humidity were found in kitchens and bathrooms, extreme temperatures in a car and a backpack, and extremely low temperatures in checked-in luggage on a plane. DISCUSSION: Temperature- and humidity-sensitive medicines should not be stored long-term in common storage locations, such as kitchens and bathrooms. Conditions in these places may not comply with the recommended storage conditions given by the manufacturer. Furthermore, medicines should not be left in backpacks or cars, especially if the vehicle is in the sun. Medicines that may degrade upon freezing and thawing-such as protein-containing medicines, emulsions, suspensions and some solutions-should not be stored in the cargo hold of a plane. FAU - Hewson, Campbell AU - Hewson C AD - School of Pharmacy, University of Otago, PO Box 56, Dunedin 9054, New Zealand. pauline.norris@otago.ac.nz FAU - Shen, Chong Chi AU - Shen CC FAU - Strachan, Clare AU - Strachan C FAU - Norris, Pauline AU - Norris P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130601 PL - Australia TA - J Prim Health Care JT - Journal of primary health care JID - 101524060 SB - IM MH - Automobiles MH - Drug Storage/*methods/*statistics & numerical data MH - Housing MH - Humans MH - *Humidity MH - New Zealand MH - *Temperature EDAT- 2013/06/12 06:00 MHDA- 2014/02/26 06:00 CRDT- 2013/06/11 06:00 PHST- 2013/06/11 06:00 [entrez] PHST- 2013/06/12 06:00 [pubmed] PHST- 2014/02/26 06:00 [medline] PST - epublish SO - J Prim Health Care. 2013 Jun 1;5(2):146-50. PMID- 25121237 STAT- Publisher ISBN- 0-309-04438-3 PB - National Academies Press (US) DP - 1991 BTI - Considerations in Contact Lens Use Under Adverse Conditions: Proceedings of a Symposium AB - This book summarizes current understanding of the scientific, clinical, and technical issues surrounding the use of contact lenses. It discusses the special occupational conditions experienced by military personnel, particularly in extreme environments, that give rise to the question of whether or not to use contact lenses. Experts in optometry, ophthalmology, visual psychophysics, and engineering describe recent developments in design and use; and representatives of the military services provide examples of actual situations in aerospace settings. Considerations in Contact Lens Use Under Adverse Conditions will be of particular interest to those involved in the design of contact lenses and those responsible for occupational safety and health matters in the private sector. CI - Copyright © National Academy of Sciences. FED - Ebert Flattau, Pamela ED - Ebert Flattau P CN - National Research Council (US) Working Group on Contact Lens Use Under Adverse Conditions LA - eng PT - Review PT - Book PL - Washington (DC) EDAT- 1991/01/01 00:00 CRDT- 1991/01/01 00:00 AID - NBK234114 [bookaccession] AID - 10.17226/1773 [doi] PMID- 33194223 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231112 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 6 IP - 1 DP - 2020 TI - Managing the combined consequences of COVID-19 infection and lock-down policies on athletes: narrative review and guidelines proposal for a safe return to sport. PG - e000849 LID - 10.1136/bmjsem-2020-000849 [doi] LID - e000849 AB - COVID-19 pandemic is a global health matter. The disease spread rapidly across the globe and brought the world of sports to an unprecedented stoppage. Usual symptoms of the disease are fever, cough, myalgia, fatigue, slight dyspnoea, sore throat and headache. In more severe cases, dyspnoea, hypoxaemia, respiratory failure, shock and multiorgan failure occur. This appears to be a self-limiting phenomenon related to individuals with coexisting medical conditions, such as hypertension, diabetes and cardiovascular disorders. Nevertheless, cases have been reported in professional soccer players in extremely good fitness condition, demonstrating that athletes are not spared by the disease. Despite COVID-19 clinical manifestations are mainly respiratory, major cardiac complications are being reported, leading to acute myocarditis. One difficulty is that symptoms of COVID-19 vary among individuals, with athletes being affected with no apparent sign of the disease. This could be a real danger for amateur or professional athletes when returning to their usual training and thus to play. Another threat is that the lock-down policies did not allow most athletes to follow their usual training routines. There is thus a need for a careful approach by the sports medicine community to ensure safety of all athletes before they return to sport. Here, we propose evaluation guidelines of fitness and health of athletes to (1) reduce any lethal risk of practice, especially myocarditis and sudden cardiac death; (2) evaluate the combined consequences of the disease and detraining on the physical abilities and biological profile of athletes; and (3) monitor postinfection fatigue symptoms. CI - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. FAU - Fabre, Jean-Bernard AU - Fabre JB AUID- ORCID: 0000-0003-3317-1976 AD - Human Motion Analysis, Humanfab, Aix-en-Provence,France. FAU - Grelot, Laurent AU - Grelot L AD - Health and Safety Department, Aix-Marseille-University,Marseille, France. FAU - Vanbiervielt, William AU - Vanbiervielt W AD - Physical Therapy, Humanfab, Aix-en-Provence,France. FAU - Mazerie, Julien AU - Mazerie J AD - Human Motion Analysis, Humanfab, Aix-en-Provence,France. FAU - Manca, Raphael AU - Manca R AD - Institut Universitaire de France (IUF), Paris, France. FAU - Martin, Vincent AU - Martin V AD - Université Clermont Auvergne, AME2P, Clermont-Ferrand,France. LA - eng PT - Journal Article PT - Review DEP - 20201019 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC7610250 OTO - NOTNLM OT - Physiology OT - cardiology OT - exercise OT - respiratory OT - sports & exercise medicine COIS- Competing interests: None declared. EDAT- 2020/11/17 06:00 MHDA- 2020/11/17 06:01 PMCR- 2020/10/19 CRDT- 2020/11/16 08:50 PHST- 2020/05/27 00:00 [received] PHST- 2020/09/04 00:00 [revised] PHST- 2020/10/03 00:00 [accepted] PHST- 2020/11/16 08:50 [entrez] PHST- 2020/11/17 06:00 [pubmed] PHST- 2020/11/17 06:01 [medline] PHST- 2020/10/19 00:00 [pmc-release] AID - bmjsem-2020-000849 [pii] AID - 10.1136/bmjsem-2020-000849 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2020 Oct 19;6(1):e000849. doi: 10.1136/bmjsem-2020-000849. eCollection 2020. PMID- 39201166 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 12 IP - 16 DP - 2024 Aug 12 TI - Effects of Community Assets on Major Health Conditions in England: A Data Analytic Approach. LID - 10.3390/healthcare12161608 [doi] LID - 1608 AB - INTRODUCTION: The broader determinants of health including a wide range of community assets are extremely important in relation to public health outcomes. Multiple health conditions, multimorbidity, is a growing problem in many populations worldwide. METHODS: This paper quantified the effect of community assets on major health conditions for the population of England over six years, at a fine spatial scale using a data analytic approach. Community assets, which included indices of the health system, green space, pollution, poverty, urban environment, safety, and sport and leisure facilities, were quantified in relation to major health conditions. The health conditions examined included high blood pressure, obesity, dementia, diabetes, mental health, cardiovascular conditions, musculoskeletal conditions, respiratory conditions, kidney and liver disease, and cancer. Cluster analysis and dendrograms were calculated for the community assets and major health conditions. For each health condition, a statistical model with all community assets was fitted, and model selection was performed. The number of significant community assets for each health condition was recorded. The unique variance, explained by each significant community asset per health condition, was quantified using hierarchical variance partitioning within an analysis of variance model. RESULTS: The resulting data indicate major health conditions are often clustered, as are community assets. The results suggest that diversity and richness of community assets are key to major health condition outcomes. Primary care service waiting times and distance to public parks were significant predictors of all health conditions examined. Primary care waiting times explained the vast majority of the variances across health conditions, with the exception of obesity, which was better explained by absolute poverty. CONCLUSIONS: The implications of the combined findings of the health condition clusters and explanatory power of community assets are discussed. The vast majority of determinants of health could be accounted for by healthcare system performance and distance to public green space, with important covariate socioeconomic factors. Emphases on community approaches, significant relationships, and asset strengths and deficits are needed alongside targeted interventions. Whilst the performance of the public health system remains of key importance, community assets and local infrastructure remain paramount to the broader determinants of health. FAU - Moustakas, Aristides AU - Moustakas A AUID- ORCID: 0000-0002-6334-747X AD - Arts and Sciences, University College London, Gower Street, London WC1E 6BT, UK. AD - Natural History Museum of Crete, University of Crete, 700 13 Haraklion, Crete, Greece. FAU - Thomson, Linda J M AU - Thomson LJM AUID- ORCID: 0000-0002-9685-3678 AD - Arts and Sciences, University College London, Gower Street, London WC1E 6BT, UK. FAU - Mughal, Rabya AU - Mughal R AD - Arts and Sciences, University College London, Gower Street, London WC1E 6BT, UK. FAU - Chatterjee, Helen J AU - Chatterjee HJ AUID- ORCID: 0000-0001-7943-1580 AD - Arts and Sciences, University College London, Gower Street, London WC1E 6BT, UK. AD - Division of Biosciences, Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK. LA - eng GR - AH/W006405/1/UK Research and Innovation/ PT - Journal Article DEP - 20240812 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC11353348 OTO - NOTNLM OT - community assets OT - data analytics OT - environmental health OT - green space OT - healthcare OT - multimorbidity COIS- The authors declare no conflict of interest. EDAT- 2024/08/31 09:44 MHDA- 2024/08/31 09:45 PMCR- 2024/08/12 CRDT- 2024/08/29 01:11 PHST- 2024/06/19 00:00 [received] PHST- 2024/07/30 00:00 [revised] PHST- 2024/08/08 00:00 [accepted] PHST- 2024/08/31 09:45 [medline] PHST- 2024/08/31 09:44 [pubmed] PHST- 2024/08/29 01:11 [entrez] PHST- 2024/08/12 00:00 [pmc-release] AID - healthcare12161608 [pii] AID - healthcare-12-01608 [pii] AID - 10.3390/healthcare12161608 [doi] PST - epublish SO - Healthcare (Basel). 2024 Aug 12;12(16):1608. doi: 10.3390/healthcare12161608. PMID- 2666958 OWN - NLM STAT- MEDLINE DCOM- 19890905 LR - 20190912 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 9 IP - 3 DP - 1989 TI - The treatment of alcohol withdrawal. PG - 131-43 AB - Abrupt cessation of regular use of alcohol in a dependent person causes a withdrawal syndrome that may range from mild to extremely severe. Most patients require pharmacologic intervention, especially those with severe symptoms. Historically, the pharmacotherapy of alcohol withdrawal has involved a wide variety of agents. Benzodiazepines are currently preferred due to their consistently high degree of efficacy and laudable record of safety. In addition, beta blockers and clonidine are useful, as both effectively combat the hypertension and tachycardia commonly associated with withdrawal. They are ineffective as anticonvulsants; however. Opinions differ concerning the best treatment for withdrawal seizures. Prophylaxis with benzodiazepines may be all that is required, although some authors advocate the use of phenytoin for 5 days, especially in persons with a history of prior seizures during alcohol withdrawal. Once established, delirium tremens are difficult to treat. Benzodiazepines are most commonly used to provide sedation, and extremely large doses may be required. Careful clinical assessment is essential to the proper treatment of patients undergoing alcohol withdrawal since the coexistence of medical problems may complicate the condition. FAU - Guthrie, S K AU - Guthrie SK AD - College of Pharmacy, University of Michigan, Ann Arbor 48109-1065. LA - eng PT - Journal Article PT - Review PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 3K9958V90M (Ethanol) SB - IM MH - Alcoholism/*therapy MH - Ethanol/*adverse effects MH - Humans MH - Substance Withdrawal Syndrome/*therapy RF - 117 EDAT- 1989/01/01 00:00 MHDA- 1989/01/01 00:01 CRDT- 1989/01/01 00:00 PHST- 1989/01/01 00:00 [pubmed] PHST- 1989/01/01 00:01 [medline] PHST- 1989/01/01 00:00 [entrez] AID - 10.1002/j.1875-9114.1989.tb04119.x [doi] PST - ppublish SO - Pharmacotherapy. 1989;9(3):131-43. doi: 10.1002/j.1875-9114.1989.tb04119.x. PMID- 10488476 OWN - NLM STAT- MEDLINE DCOM- 19991026 LR - 20160321 IS - 0953-1424 (Print) IS - 0953-1424 (Linking) VI - 12 IP - 3 DP - 1999 Sep TI - The possible role of magnesium in protection of premature infants from neurological syndromes and visual impairments and a review of survival of magnesium-exposed premature infants. PG - 201-16 AB - The survival rate of very preterm, low birth weight infants (weighing less than 1500 g) is 85 per cent in the USA and is ever increasing, while 42 to 75 per cent of extremely premature infants (weighing 751-1000 g) survive. Of great concern is the lack of consistent decrease in neurological syndromes and associated visual impairments. Because of short gestations, these infants have not had time to accrue up to 80 per cent of magnesium normally present at term. These very preterm infants are at highest risk for cerebral hypoxia/ischemia (H/I), intracranial hemorrhage (ICH), periventricular leukomalacia (PVL) or cystic PVL (CPVL), and possible sequelae, cerebral palsy (CP) and mental retardation (MR). These syndromes are associated with damage to optic structures and the visual pathways which traverse the brain. Visual defects are common in surviving preterm infants. Increased levels of harmful neurochemical mediators that have been reported in these conditions include oxygen free radicals, excitatory amino acids, tumor necrosis factor-alpha (TNF-a), and thromboxane A2 (TXA2) which are aggravated in magnesium deficiency and may be ameliorated by magnesium. We review the published data concerning the effects of prenatal magnesium supplementation on ICH, CPVL, CP and MR and available reports concerning survival. Further considerations on the safety and efficacy of magnesium sulphate administration given prenatally to the preterm neonate await the outcome of three trials that are continuing for more than a year on three continents. FAU - Caddell, J L AU - Caddell JL AD - Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107-5083, USA. FAU - Graziani, L J AU - Graziani LJ FAU - Wiswell, T E AU - Wiswell TE FAU - Hsieh, H C AU - Hsieh HC FAU - Mansmann, H C Jr AU - Mansmann HC Jr LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Magnes Res JT - Magnesium research JID - 8900948 RN - I38ZP9992A (Magnesium) SB - IM MH - Humans MH - Infant, Newborn MH - *Infant, Premature MH - *Magnesium/pharmacology/therapeutic use MH - Nervous System Diseases/*prevention & control MH - Syndrome MH - *Visual Pathways/drug effects/pathology/physiopathology RF - 118 EDAT- 1999/09/17 09:00 MHDA- 2001/03/28 10:01 CRDT- 1999/09/17 09:00 PHST- 1999/09/17 09:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1999/09/17 09:00 [entrez] PST - ppublish SO - Magnes Res. 1999 Sep;12(3):201-16. PMID- 11499977 OWN - NLM STAT- MEDLINE DCOM- 20011011 LR - 20191105 IS - 1246-7820 (Print) IS - 1246-7820 (Linking) VI - 8 IP - 3 DP - 2001 Jun TI - Mechanisms of severe transfusion reactions. PG - 278-81 AB - Serious adverse effects of transfusion may be immunologically or non-immunologically mediated. Currently, bacterial contamination of blood products, particularly platelets, is one of the most significant causes of transfusion-related morbidity and mortality. Septic transfusion reactions can present with clinical symptoms similar to immune-mediated hemolytic transfusion reactions and transfusion-related acute lung injury. Extremely high fever and/or gastrointestinal symptoms, in a transfusion recipient, may be indicative of sepsis. The diagnosis is based upon culturing the same organism from both the patient and the transfused blood component. Numerous organisms have been implicated as the cause of septic transfusion reactions. Due to different storage conditions, gram negative organisms are more often isolated from red blood cell components; gram positive organisms are more often isolated from platelets. Prevention of septic transfusion reactions is primarily dependent on an adequate donor history and meticulous preparation of the donor phlebotomy site. Visual inspection of blood components prior to transfusion is also vital to preventing these reactions. Several methods of detection of bacterial contamination and inactivation of pathogens are currently under active investigation. FAU - Kopko, P M AU - Kopko PM AD - Sacramento Blood Centers, CA 95816-7089, United States. FAU - Holland, P V AU - Holland PV LA - eng PT - Journal Article PT - Review PL - France TA - Transfus Clin Biol JT - Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine JID - 9423846 SB - IM MH - Bacteremia/epidemiology/prevention & control/transmission MH - Blood/microbiology MH - Blood Preservation MH - Blood Transfusion, Autologous/adverse effects MH - Equipment Contamination MH - Gram-Negative Bacterial Infections/diagnosis/epidemiology/etiology/prevention & control/transmission MH - Gram-Positive Bacterial Infections/diagnosis/epidemiology/etiology/prevention & control/transmission MH - Humans MH - Mass Screening MH - Models, Biological MH - Mouth/microbiology MH - Prevalence MH - Safety MH - Sepsis/diagnosis/epidemiology/etiology/microbiology/prevention & control MH - Skin/microbiology MH - *Transfusion Reaction RF - 28 EDAT- 2001/08/14 10:00 MHDA- 2001/10/12 10:01 CRDT- 2001/08/14 10:00 PHST- 2001/08/14 10:00 [pubmed] PHST- 2001/10/12 10:01 [medline] PHST- 2001/08/14 10:00 [entrez] AID - S1246-7820(01)00113-6 [pii] AID - 10.1016/s1246-7820(01)00113-6 [doi] PST - ppublish SO - Transfus Clin Biol. 2001 Jun;8(3):278-81. doi: 10.1016/s1246-7820(01)00113-6. PMID- 36144040 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220928 IS - 2072-666X (Print) IS - 2072-666X (Electronic) IS - 2072-666X (Linking) VI - 13 IP - 9 DP - 2022 Aug 28 TI - Transient Heat Transfer Characteristics in a Flat Plate Heat Sink with Mini-Channels for Cooling High Heat Flux IGBT. LID - 10.3390/mi13091417 [doi] LID - 1417 AB - Effective cooling of a high heat flux IGBT electronic system is highly related to system efficiency and safety. A flat plate heat sink was designed to experimentally investigate the transient heat transfer characteristics of IGBT cooling. It is made of aluminum with 20 mini-channels of 249 mm × 3 mm × 4 mm dimensions, which were manufactured by milling machines and melt inert gas (MIG) welding technology to ensure no deformation. Experiments were conducted using deionized water at atmospheric pressure with flow rates of 3.2-9.5 L/min and heat fluxes of 104-347 W/cm(2). It was found that instantaneous start-stop and transient heating power variation might cause IGBT failure, especially under low Reynolds and Nusselt number conditions. The temperature rise rate and cooling rate vary with different system parameters. Heating rate can be reduced by high flow rate due to local subcooled boiling. The concept of respond time (RT) based on the piecewise function is suggested to evaluate the influence of transient condition on heating rate. Analysis of flow fluctuation indicated that it would not be a threat to the system except for in extreme cases. These findings provide a reference for the considerations of the design and manufacture of IGBT cooling flat plate heat sinks with mini-channels. FAU - Chen, Changnian AU - Chen C AUID- ORCID: 0000-0002-2800-1123 AD - School of Energy and Power Engineering, Shandong University, Jinan 250061, China. AD - Optics & Thermal Radiation Research Center, Shandong University, Qingdao 266237, China. FAU - Zhao, Haoran AU - Zhao H AD - School of Electrical Engineering, Shandong University, Jinan 250061, China. FAU - Liu, Chaoyu AU - Liu C AD - Shandong Guochen Equipment Installation Co., Ltd., Jinan 250305, China. FAU - Chen, Jian AU - Chen J AD - School of Electrical Engineering, Shandong University, Jinan 250061, China. FAU - Liu, Chunyang AU - Liu C AD - School of Electrical Engineering, Shandong University, Jinan 250061, China. FAU - Zhang, Tiezhu AU - Zhang T AD - Taishan Fiberglass Inc., Taian 271000, China. FAU - Gong, Weiping AU - Gong W AD - School of Energy and Power Engineering, Shandong University, Jinan 250061, China. LA - eng GR - 51706124/National Natural Science Foundation of China/ GR - 2018YFA0702200/National Key R&D Program of China/ PT - Journal Article DEP - 20220828 PL - Switzerland TA - Micromachines (Basel) JT - Micromachines JID - 101640903 PMC - PMC9505866 OTO - NOTNLM OT - IGBT OT - flat plate heat sink OT - high heat flux OT - mini-channel OT - transient heat transfer COIS- The authors declare no conflict of interest. EDAT- 2022/09/24 06:00 MHDA- 2022/09/24 06:01 PMCR- 2022/08/28 CRDT- 2022/09/23 01:33 PHST- 2022/08/03 00:00 [received] PHST- 2022/08/22 00:00 [revised] PHST- 2022/08/24 00:00 [accepted] PHST- 2022/09/23 01:33 [entrez] PHST- 2022/09/24 06:00 [pubmed] PHST- 2022/09/24 06:01 [medline] PHST- 2022/08/28 00:00 [pmc-release] AID - mi13091417 [pii] AID - micromachines-13-01417 [pii] AID - 10.3390/mi13091417 [doi] PST - epublish SO - Micromachines (Basel). 2022 Aug 28;13(9):1417. doi: 10.3390/mi13091417. PMID- 29060369 OWN - NLM STAT- MEDLINE DCOM- 20180810 LR - 20200928 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2017 DP - 2017 Jul TI - Wearable bio signal monitoring system applied to aviation safety. PG - 2349-2352 LID - 10.1109/EMBC.2017.8037327 [doi] AB - Pilots are required to have the ability to evaluate their own physical and psychological status to operate high performance aircrafts effectively. Existing studies have lacked consideration of applying bio signal of pilots in real time flight situation. The purpose of this study is to develop a wearable bio signal monitoring system that can measure the condition of pilots under an extreme flight environment to ensure flight safety. The wearable bio signal monitoring system consists of an algorithm for evaluating pilots' physiological stability, algorithms for detecting Gravity-induced Loss of Consciousness (G-LOC) prognosis, pilots' interaction module, and pilots' context awareness platform. The algorithm for evaluating pilots' physiological stability uses psychomotor cognitive test (PCT) and heart rate variability (HRV) to measure pilots' mission performance before flight. The algorithms for detecting G-LOC prognosis utilizes electromyogram (EMG) to generate warning signal during flight. The pilots' interaction module was developed for pilots to operate the system efficiently under flight environment. The pilots' context awareness platform was designed for the system to process multiple sensor signals in real time. This wearable bio signal monitoring system is expected to enhance flight safety and mission performance of pilots. FAU - Sungho Kim AU - Sungho Kim FAU - Booyong Choi AU - Booyong Choi FAU - Taehwan Cho AU - Taehwan Cho FAU - Yongkyun Lee AU - Yongkyun Lee FAU - Hyojin Koo AU - Hyojin Koo FAU - Dongsoo Kim AU - Dongsoo Kim LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Aerospace Medicine MH - Aircraft MH - Aviation MH - Awareness MH - Electromyography MH - *Wearable Electronic Devices EDAT- 2017/10/25 06:00 MHDA- 2018/08/11 06:00 CRDT- 2017/10/25 06:00 PHST- 2017/10/25 06:00 [entrez] PHST- 2017/10/25 06:00 [pubmed] PHST- 2018/08/11 06:00 [medline] AID - 10.1109/EMBC.2017.8037327 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul;2017:2349-2352. doi: 10.1109/EMBC.2017.8037327. PMID- 38428244 OWN - NLM STAT- MEDLINE DCOM- 20240319 LR - 20240319 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 199 DP - 2024 May TI - Real-time combined safety-mobility assessment using self-driving vehicles collected data. PG - 107513 LID - S0001-4575(24)00058-7 [pii] LID - 10.1016/j.aap.2024.107513 [doi] AB - The study presents a real-time safety and mobility assessment approach using data generated by autonomous vehicles (AVs). The proposed safety assessment method uses Bayesian hierarchical spatial random parameter extreme value model (BHSRP), which can handle the limited availability and uneven distribution of conflict data and accounts for unobserved spatial heterogeneity. The approach estimates two real-time safety metrics: the risk of crash (RC) and return level (RL), using Time-To-Collision (TTC) as conflict indicator. Additionally, a Risk Exposure (RE) index was developed to reflect the risk of an individual vehicle to travel through a corridor. In parallel, the mobility of corridor were assessed based on the highway Capacity manual methodology using real-time traffic data (Highway Capacity Manual, 2010). The study used a 440-hour AVs' dataset of a corridor in Palo Alto, California. After normalizing for each LOS representation in the dataset, LOS E was identified as the most hazardous operating condition with the highest average crash risk. However, the time spent under different operating condition would affect the safety of individual vehicles traveling through a road facility (i.e., vehicle's exposure time). Accounting for exposure time, the vehicle has the highest chance of encountering an extremely risky driving condition at intersections and segments under LOS D and E, respectively. CI - Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Kamel, Ahmed AU - Kamel A AD - Department of Civil Engineering, The University of British Columbia, Canada. FAU - Sayed, Tarek AU - Sayed T AD - Department of Civil Engineering, The University of British Columbia, Canada. Electronic address: tsayed@civil.ubc.ca. FAU - Kamel, Mohamed AU - Kamel M AD - Department of Research and Analytics, TransLink, Canada. LA - eng PT - Journal Article DEP - 20240229 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Humans MH - *Autonomous Vehicles MH - Bayes Theorem MH - *Accidents, Traffic/prevention & control MH - Benchmarking MH - Travel OTO - NOTNLM OT - Autonomous vehicles OT - Conflict extremes OT - Extreme value theory models OT - Real-time safety analysis OT - Safety-mobility assessment OT - Self-driving COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/02 10:44 MHDA- 2024/03/19 06:44 CRDT- 2024/03/01 18:08 PHST- 2023/09/17 00:00 [received] PHST- 2024/01/28 00:00 [revised] PHST- 2024/02/18 00:00 [accepted] PHST- 2024/03/19 06:44 [medline] PHST- 2024/03/02 10:44 [pubmed] PHST- 2024/03/01 18:08 [entrez] AID - S0001-4575(24)00058-7 [pii] AID - 10.1016/j.aap.2024.107513 [doi] PST - ppublish SO - Accid Anal Prev. 2024 May;199:107513. doi: 10.1016/j.aap.2024.107513. Epub 2024 Feb 29. PMID- 34934448 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211223 IS - 1792-1015 (Electronic) IS - 1792-0981 (Print) IS - 1792-0981 (Linking) VI - 23 IP - 1 DP - 2022 Jan TI - Endoscopic assessment of sinonasal mucormycosis with SPIES: The 'battlefield' sign. PG - 77 LID - 10.3892/etm.2021.11000 [doi] LID - 77 AB - Sinonasal mucormycosis is an extremely challenging pathology for the ear, nose and throat (ENT) surgeon from a therapeutic point of view. The disease affects immunocompromised patients and exhibits lethal potential. Although the diagnosis is relatively easy to suspect due to the distinctive clinical aspects which consists of black crusting present in the nasal fossae able to be confirmed by biopsy, the treatment requires resection of all affected tissue with safety limits. Due to the tendency of invasion associated with this fungal infection and taking into account the location involved (the sinonasal area) and the grave condition of these patients, it is extremely important to perform only the minimal resection necessary, but that includes all tissue infected by the fungus. This article presents a minimally invasive method of evaluation that can be performed during endoscopic surgical intervention and that aids the surgeon to better evaluate the affected area. It is associated with no additional risks for the patients, but it helps the surgeon to perform the intervention efficiently while not damaging healthy tissue. The authors consider that the method presented will aid the surgeon during the endoscopic surgical intervention in evaluating the lesion and resecting all the affected tissue while preserving healthy areas. CI - Copyright © 2020, Spandidos Publications. FAU - Zainea, Viorel AU - Zainea V AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. AD - Department of ENT, 'Prof. Dr. D. Hociota' Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania. FAU - Ionita, Irina Gabriela AU - Ionita IG AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. AD - Department of ENT, 'Prof. Dr. D. Hociota' Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania. FAU - Pituru, Silviu AU - Pituru S AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Pietroșanu, Cătălina AU - Pietroșanu C AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. AD - Department of ENT, 'Prof. Dr. D. Hociota' Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania. FAU - Rusescu, Andreea AU - Rusescu A AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Stefanescu, Cristian Dragos AU - Stefanescu CD AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. AD - Department of ENT, 'Prof. Dr. D. Hociota' Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania. FAU - Gherghiceanu, Florentina AU - Gherghiceanu F AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Anghelina, Florin AU - Anghelina F AD - Department of ENT, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of ENT, Emergency County Hospital Craiova, 200642 Craiova, Romania. FAU - Palade, Dragos AU - Palade D AD - Department of ENT, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Department of ENT, 'Sf. Spiridon' Emergency University Hospital, 700111 Iasi, Romania. FAU - Hainarosie, Razvan AU - Hainarosie R AD - Department of ENT, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania. AD - Department of ENT, 'Prof. Dr. D. Hociota' Institute of Phonoaudiology and Functional ENT Surgery, 061344 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20211125 PL - Greece TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC8652392 OTO - NOTNLM OT - SPIES endoscopy OT - endoscopic evaluation OT - healthy tissue resection OT - minimally invasive OT - sinonasal mucormycosis COIS- The authors declare no competing interests. EDAT- 2021/12/23 06:00 MHDA- 2021/12/23 06:01 PMCR- 2021/11/25 CRDT- 2021/12/22 06:48 PHST- 2021/07/16 00:00 [received] PHST- 2021/08/17 00:00 [accepted] PHST- 2021/12/22 06:48 [entrez] PHST- 2021/12/23 06:00 [pubmed] PHST- 2021/12/23 06:01 [medline] PHST- 2021/11/25 00:00 [pmc-release] AID - ETM-0-0-11000 [pii] AID - 10.3892/etm.2021.11000 [doi] PST - ppublish SO - Exp Ther Med. 2022 Jan;23(1):77. doi: 10.3892/etm.2021.11000. Epub 2021 Nov 25. PMID- 19195134 OWN - NLM STAT- MEDLINE DCOM- 20090505 LR - 20191111 IS - 1473-6586 (Electronic) IS - 0963-0643 (Linking) VI - 19 IP - 2 DP - 2009 Mar TI - The effect of age on outcomes in patients undergoing treatment for renal stones. PG - 211-4 AB - PURPOSE OF REVIEW: Standard guidelines in management of urolithiasis might not be applicable to patients of extreme ages, namely children and the elderly population. This review summarizes the latest evidence on the effects of age on the outcomes, both treatment results and complications, in various treatment modalities for stone disease. RECENT FINDINGS: Although age has been recently reported to be a significant negative predictor in elderly patients with renal stones receiving shock wave lithotripsy (SWL) treatment, there is increasing evidence suggesting SWL is well tolerated in children. For percutaneous nephrolithotomy and ureteroscopy, literature has shown that the outcomes in both age groups are similar to normal adult patients. SUMMARY: Age does affect treatment outcome in patients with urinary stones. With the advance in endoscopy design and experience, percutaneous nephrolithotomy and ureteroscopy in these two extremes of age seem to be providing the same efficacy and safety as the standard adult population. However, for SWL, more precautions are to be taken for pediatric patients. For elderly patients, SWL may actually have a less satisfactory result than the other treatment modalities. FAU - Ng, Chi-Fai AU - Ng CF AD - Division of Urology, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China. ngcf@surgery.cuhk.edu.hk LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Urol JT - Current opinion in urology JID - 9200621 SB - IM MH - Age Factors MH - Aged MH - Child MH - Humans MH - Lithotripsy/adverse effects MH - Nephrostomy, Percutaneous MH - Treatment Outcome MH - Ureteroscopy MH - Urolithiasis/epidemiology/*therapy RF - 38 EDAT- 2009/02/07 09:00 MHDA- 2009/05/06 09:00 CRDT- 2009/02/07 09:00 PHST- 2009/02/07 09:00 [entrez] PHST- 2009/02/07 09:00 [pubmed] PHST- 2009/05/06 09:00 [medline] AID - 10.1097/mou.0b013e32831e16b7 [doi] PST - ppublish SO - Curr Opin Urol. 2009 Mar;19(2):211-4. doi: 10.1097/mou.0b013e32831e16b7. PMID- 7796960 OWN - NLM STAT- MEDLINE DCOM- 19950801 LR - 20051116 IS - 0301-5149 (Print) IS - 0301-5149 (Linking) VI - 84 DP - 1995 TI - Vibrio cholerae CVD103-HgR live oral attenuated vaccine: construction, safety, immunogenicity, excretion and non-target effects. PG - 237-44 AB - In many controlled studies, CVD103-HgR has been shown to be safe and immunogenic and to offer a significant degree of protection against experimental cholera after a single dose. Its minimal excretion and limited ability to compete and survive in various ecosystems indicate that this strain presents little risk to the environment. Furthermore, the potential of CVD103-HgR to regain virulence by acquisition of the CT A or LT A gene is extremely remote even under optimal conditions. Therefore, CVD103-HgR possesses those traits desired in a live oral attenuated vaccine produced by recombinant DNA technology. FAU - Cryz, S J Jr AU - Cryz SJ Jr AD - Swiss Serum and Vaccine Institute, Berne. FAU - Kaper, J AU - Kaper J FAU - Tacket, C AU - Tacket C FAU - Nataro, J AU - Nataro J FAU - Levine, M M AU - Levine MM LA - eng PT - Journal Article PT - Review PL - Switzerland TA - Dev Biol Stand JT - Developments in biological standardization JID - 0427140 RN - 0 (Cholera Vaccines) RN - 0 (Vaccines, Attenuated) SB - IM MH - Adult MH - Child MH - Child, Preschool MH - Cholera Vaccines/adverse effects/immunology/*isolation & purification MH - Environmental Microbiology MH - Feces/microbiology MH - Humans MH - Recombination, Genetic MH - Safety MH - Vaccines, Attenuated/adverse effects/immunology/isolation & purification MH - Vibrio cholerae/genetics/immunology/isolation & purification RF - 14 EDAT- 1995/01/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1995/01/01 00:00 [entrez] PST - ppublish SO - Dev Biol Stand. 1995;84:237-44. PMID- 38981395 OWN - NLM STAT- MEDLINE DCOM- 20240814 LR - 20240814 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 282 DP - 2024 Sep 1 TI - Association between ambient temperature and cause-specific mortality: An individual-level case-crossover study in Suzhou, China. PG - 116687 LID - S0147-6513(24)00763-2 [pii] LID - 10.1016/j.ecoenv.2024.116687 [doi] AB - The changing climate poses a growing challenge to the population health. The objective of this study was to assess the association between ambient temperature and cause-specific mortality in Suzhou. Based on the non-accidental mortality data collected during 2008-2022 in Suzhou, China, this study utilized an individual-level case-crossover design to evaluate the associations of temperature with cause-specific mortality. We applied a distributed lag nonlinear model with a maximum lag of 14 days to account for lag effects. Mortality risk due to extreme cold (<2.5th percentile) and extreme heat (>97.5th percentile) was analyzed. A total of 634,530 non-accidental deaths were analyzed in this study. An inverse J-shaped exposure-response relationship was observed between ambient temperature and non-accidental mortality, with the minimum mortality temperature (MMT) at 29.1℃. The relative risk (RR) of mortality associated with extreme cold (2.5th percentile) was 1.37 [95 % confidence interval (CI): 1.30, 1.44], higher than estimate of 1.09 (95 %CI: 1.07, 1.11) for extreme heat (97.5th percentile) relative to the MMT. Heat effect lasted for 2-3 days, while cold effect could persist for almost 14 days. Higher mortality risk estimates were observed for cardiorespiratory deaths compared to total deaths, with statistically significant between-group differences. Consequently, this study provides first-hand evidence on the associations between ambient temperatures and mortality risks from various causes, which could help local government and policy-makers in designing targeted strategies and public health measures against the menace of climate change. CI - Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Hua, Yujie AU - Hua Y AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. FAU - Zhou, Lu AU - Zhou L AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200032, China. FAU - Liu, Fang AU - Liu F AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. FAU - Yang, Haibing AU - Yang H AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. FAU - Wang, Linchi AU - Wang L AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. FAU - Huang, Chunyan AU - Huang C AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. FAU - Liu, Cong AU - Liu C AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200032, China. FAU - Lu, Yan AU - Lu Y AD - Department of Non-communicable Chronic Disease Control and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China. Electronic address: szly0700@sina.com. FAU - Wang, Haitao AU - Wang H AD - Department of Disease Control, SuZhou Municipal Health Commission, Suzhou 215002, China. Electronic address: sky200205@126.com. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200032, China. Electronic address: kanh@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20240708 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 SB - IM MH - China/epidemiology MH - Humans MH - *Cross-Over Studies MH - Female MH - Male MH - Mortality/trends MH - Middle Aged MH - Climate Change MH - Adult MH - Temperature MH - Environmental Exposure/statistics & numerical data/adverse effects MH - Aged MH - Cause of Death MH - Young Adult MH - Extreme Heat/adverse effects OTO - NOTNLM OT - Cardiorespiratory diseases OT - Case-crossover study OT - Climate change OT - Mortality OT - Non-optimum temperature COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper EDAT- 2024/07/10 00:41 MHDA- 2024/08/15 00:42 CRDT- 2024/07/09 18:09 PHST- 2024/03/30 00:00 [received] PHST- 2024/06/25 00:00 [revised] PHST- 2024/07/02 00:00 [accepted] PHST- 2024/08/15 00:42 [medline] PHST- 2024/07/10 00:41 [pubmed] PHST- 2024/07/09 18:09 [entrez] AID - S0147-6513(24)00763-2 [pii] AID - 10.1016/j.ecoenv.2024.116687 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2024 Sep 1;282:116687. doi: 10.1016/j.ecoenv.2024.116687. Epub 2024 Jul 8. PMID- 10955262 OWN - NLM STAT- MEDLINE DCOM- 20001207 LR - 20220331 IS - 0883-9212 (Print) IS - 0883-9212 (Linking) VI - 20 IP - 4 DP - 2000 Jul-Aug TI - The Finnish sauna bath and its use in patients with cardiovascular disease. PG - 225-30 AB - The Finnish tradition of sauna bathing is meant to be an experience in relaxation, and the length of time spent in the sauna and the preferred temperature vary considerably among individuals. The pleasures of sauna bathing can be considered safe and without undue risk of cardiac complications even for CVD patients, providing bathing is conducted sensibly for an appropriate period of time, and extremes in temperature are voided. FAU - Keast, M L AU - Keast ML AD - University of Ottawa Heart Institute Prevention and Rehabilitation Centre, Ontario, Canada. mkeast@ottawaheart.ca FAU - Adamo, K B AU - Adamo KB LA - eng PT - Journal Article PT - Review PL - United States TA - J Cardiopulm Rehabil JT - Journal of cardiopulmonary rehabilitation JID - 8511296 RN - 0 (Hormones) SB - IM MH - Adult MH - Aged MH - Blood Circulation MH - Blood Pressure MH - Body Temperature MH - *Cardiovascular Diseases/physiopathology MH - Contraindications MH - Female MH - Finland MH - Heart Failure/physiopathology MH - Heart Transplantation MH - Hemodynamics MH - Hormones/blood MH - Hot Temperature MH - Humans MH - Hypertension/physiopathology MH - Male MH - Myocardial Ischemia/physiopathology MH - Physical Exertion MH - Risk Factors MH - Safety MH - Skin/blood supply MH - *Steam Bath/adverse effects MH - Temperature MH - Time Factors RF - 38 EDAT- 2000/08/24 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/08/24 11:00 PHST- 2000/08/24 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/08/24 11:00 [entrez] AID - 10.1097/00008483-200007000-00002 [doi] PST - ppublish SO - J Cardiopulm Rehabil. 2000 Jul-Aug;20(4):225-30. doi: 10.1097/00008483-200007000-00002. PMID- 18590347 OWN - NLM STAT- MEDLINE DCOM- 20080922 LR - 20220408 IS - 1089-5159 (Print) IS - 1089-5159 (Linking) VI - 13 IP - 2 DP - 2008 Jun TI - Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. PG - 85-115 AB - Alzheimer's disease, AD, is the most common form of dementia. AD initially targets memory and progressively destroys the mind. The brain atrophies as the neocortex suffers neuronal, synaptic, and dendritic losses, and the hallmark amyloid plaques and neurofibrillary tangles proliferate. Pharmacological management, at best, is palliative and transiently effective, with marked adverse effects. Certain nutrients intrinsic to human biochemistry (orthomolecules) match or exceed pharmacological drug benefits in double-blind, randomized, controlled trials, with superior safety. Early intervention is feasible because its heritability is typically minimal and pathological deterioration is detectable years prior to diagnosis. The syndrome amnestic mild cognitive impairment exhibits AD pathology and to date has frustrated attempts at intervention. The condition age-associated memory impairment is a nonpathological extreme of normal brain aging, but with less severe cognitive impairment than amnestic mild cognitive impairment. Age-associated memory impairment is a feasible target for early intervention against AD, beginning with the modifiable AD risk factors - smoking, hypertension, homocysteine, type 2 diabetes, insulin resistance, and obesity. Stress reduction, avoidance of toxins, and mental and physical exercise are important aspects of prevention. The diet should emphasize omega-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid; flavonoids and other antioxidant nutrients; and B vitamins, especially folate, B6 and B12. Dietary supplementation is best focused on those proven from randomized, controlled trials: the phospholipids phosphatidylserine and glycerophosphocholine, the energy nutrient acetyl-L-carnitine, vitamins C and E, and other antioxidants. A comprehensive integrative strategy initiated early in cognitive decline is the most pragmatic approach to controlling progression to Alzheimer's disease. FAU - Kidd, Parris M AU - Kidd PM AD - Cell biology; University of California, Berkeley, USA. dockidd@dockidd.com LA - eng PT - Journal Article PT - Review PL - United States TA - Altern Med Rev JT - Alternative medicine review : a journal of clinical therapeutic JID - 9705340 MH - Alzheimer Disease/etiology/pathology/*prevention & control MH - Amnesia/complications/diagnosis/prevention & control MH - Cognition Disorders/complications/diagnosis/*prevention & control MH - Dietary Supplements MH - Disease Progression MH - Humans MH - Memory Disorders/complications/diagnosis/*prevention & control MH - Risk Factors MH - Stress, Physiological/prevention & control RF - 187 EDAT- 2008/07/02 09:00 MHDA- 2008/09/23 09:00 CRDT- 2008/07/02 09:00 PHST- 2008/07/02 09:00 [pubmed] PHST- 2008/09/23 09:00 [medline] PHST- 2008/07/02 09:00 [entrez] PST - ppublish SO - Altern Med Rev. 2008 Jun;13(2):85-115. PMID- 37960528 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231122 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 23 IP - 21 DP - 2023 Oct 30 TI - Dynamic Threshold Cable-Stayed Bridge Health Monitoring System Based on Temperature Effect Correction. LID - 10.3390/s23218826 [doi] LID - 8826 AB - The early health warning of a cable-stayed bridge is of great significance for discovering the abnormal condition of the structure, eliminating the risk factors, and ensuring the normal operation of the bridge in order to set a reasonable safety monitoring threshold to ensure the safety warning and condition assessment of the bridge structure. A method of dynamic early warning by considering the temperature effect is adopted in this paper on the basis of the benchmark threshold. Based on the long-term deflection monitoring data of a bridge in Wuhan, the generalized Pareto distribution (GPD) extreme value analysis theory is used to set the benchmark threshold. Then, by constructing the seasonal autoregressive integrated moving average (SARIMA) long-span bridge temperature effect prediction model, the reference threshold is dynamically adjusted. Finally, it is compared with the traditional fixed threshold monitoring system. The results show that the dynamic threshold has stronger adaptability to the monitoring of cable-stayed bridges and can also achieve effective monitoring of local mutations in other periods. Dynamic threshold early warning can reduce the shortcomings of traditional early warning methods such as underreporting and misreporting. At the same time, the GPD extreme value analysis theory overcomes the disadvantage that the extreme value information is not fully utilized. It has an important application value for bridge health monitoring. FAU - Tan, Dongmei AU - Tan D AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. FAU - Guo, Tai AU - Guo T AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. FAU - Luo, Hao AU - Luo H AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. FAU - Ji, Baifeng AU - Ji B AUID- ORCID: 0000-0002-9657-8995 AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. AD - Hainan Institute, Wuhan University of Technology, Sanya 572000, China. FAU - Tao, Yu AU - Tao Y AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. FAU - Li, An AU - Li A AD - School of Civil Engineering and Architecture, Wuhan University of Technology, Wuhan 430070, China. LA - eng GR - 42271453/the National Natural Science Foundation Project/ GR - 2021JJLH0011/the Hainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology City/ PT - Journal Article DEP - 20231030 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC10648320 OTO - NOTNLM OT - cable-stayed bridge OT - dynamic threshold OT - early warning OT - health monitoring COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/11/14 06:42 MHDA- 2023/11/14 06:43 PMCR- 2023/10/30 CRDT- 2023/11/14 02:20 PHST- 2023/09/29 00:00 [received] PHST- 2023/10/24 00:00 [revised] PHST- 2023/10/26 00:00 [accepted] PHST- 2023/11/14 06:43 [medline] PHST- 2023/11/14 06:42 [pubmed] PHST- 2023/11/14 02:20 [entrez] PHST- 2023/10/30 00:00 [pmc-release] AID - s23218826 [pii] AID - sensors-23-08826 [pii] AID - 10.3390/s23218826 [doi] PST - epublish SO - Sensors (Basel). 2023 Oct 30;23(21):8826. doi: 10.3390/s23218826. PMID- 34485233 OWN - NLM STAT- MEDLINE DCOM- 20210908 LR - 20210908 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 9 DP - 2021 TI - Screening High-Risk Groups and the General Population for SARS-CoV-2 Nucleic Acids in a Mobile Biosafety Laboratory. PG - 708476 LID - 10.3389/fpubh.2021.708476 [doi] LID - 708476 AB - The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has challenged public health systems worldwide. Therefore, large-scale testing capacity is extremely important diagnosis and exclusion diagnosis. However, fixed laboratories are limited or far away from remote areas. Fortunately, MBS-Lab is characterized by high mobility and rapid on-site detection of SARS-CoV-2 nucleic acid. MBS-Lab was first used in northern Australia during a melioidosis outbreak in 1997. The MBS-Lab and a well-trained diagnostic team were dispatched to Dongchang District, Tonghua City, Jilin Province, China to assist the SARS-CoV-2 virus screening and diagnosis on January 17, 2021. Altogether, 93,952 oropharyngeal swabs samples were collected and tested among the high-risk groups and the general population in Dongchang District. Two single samples were identified as positive in the second turn screening. In the second turn screening, 3 mixed samples (10 in 1) were identified as positive; 10 mixed samples were identified as positive in the third turn screening. By resampling again, one and four cases were identified as positive, respectively. The positive cases were properly isolated and treated in hospital and avoided to visit family members, friends, colleagues and any other persons. Through this way of large-scale screening, human-human spread of SARS-CoV-2 can be effectively avoided. In addition, all staff members strictly executed multiple safety precautions and reduce exposure risks. In the end, none of the staffs was infected with SARS-CoV-2 virus or other pathogens. As an emergency facility for infectious disease control, the MBS-Lab satisfies the requirements of ports and other remote areas far from fixed laboratories and supplements the capabilities of fixed laboratories. CI - Copyright © 2021 Guo, Li, Song, Xu and Huang. FAU - Guo, Zhimin AU - Guo Z AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. FAU - Li, Lin AU - Li L AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. FAU - Song, Yuanyuan AU - Song Y AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. FAU - Xu, Jiancheng AU - Xu J AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. FAU - Huang, Jing AU - Huang J AD - Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210813 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Nucleic Acids) SB - IM MH - *COVID-19 MH - Containment of Biohazards MH - Humans MH - Laboratories MH - *Nucleic Acids MH - SARS-CoV-2 PMC - PMC8414879 OTO - NOTNLM OT - SARS-CoV-2 OT - bio-protection OT - mobile biosafety laboratory OT - nucleic acid OT - real-time PCR COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/09/07 06:00 MHDA- 2021/09/09 06:00 PMCR- 2021/08/13 CRDT- 2021/09/06 06:07 PHST- 2021/06/02 00:00 [received] PHST- 2021/07/09 00:00 [accepted] PHST- 2021/09/06 06:07 [entrez] PHST- 2021/09/07 06:00 [pubmed] PHST- 2021/09/09 06:00 [medline] PHST- 2021/08/13 00:00 [pmc-release] AID - 10.3389/fpubh.2021.708476 [doi] PST - epublish SO - Front Public Health. 2021 Aug 13;9:708476. doi: 10.3389/fpubh.2021.708476. eCollection 2021. PMID- 23647054 OWN - NLM STAT- MEDLINE DCOM- 20140505 LR - 20211021 IS - 1557-8577 (Electronic) IS - 1549-1684 (Print) IS - 1549-1684 (Linking) VI - 16 IP - 4 DP - 2013 Aug TI - A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial? PG - 285-94 LID - 10.1089/rej.2013.1425 [doi] AB - Dehydroepiandrosterone (DHEA) and its sulfate ester are the most abundant steroids in humans. DHEA levels fall with age in men and women, reaching values sometimes as low as 10%-20% of those encountered in young individuals. This age-related decrease suggests an "adrenopause" phenomenon. Studies point toward several potential roles of DHEA, mainly through its hormonal end products, making this decline clinically relevant. Unfortunately, even if positive effects of DHEA on muscle, bone, cardiovascular disease, and sexual function seem rather robust, extremely few studies are large enough and/or long enough for conclusions regarding its effects on aging. Moreover, because it has been publically presented as a "fountain of youth" equivalent, over-the-counter preparations lacking pharmacokinetic and pharmacodynamic data are widely used worldwide. Conceptually, supplementing a pre-hormone is extremely interesting, because it would permit the human organism to adequately use it throughout long periods, increasing or decreasing end products according to his needs. Nevertheless, data on the safety profile of long-term DHEA supplementation are still lacking. In this article, we examine the potential relation between low DHEA levels and well-known age-related diseases, such as sarcopenia, osteoporosis, dementia, sexual disorders, and cardiovascular disease. We also review risks and benefits of existing protocols of DHEA supplementation. FAU - Samaras, Nikolaos AU - Samaras N AD - Department of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland. nikolassamaras@hotmail.com FAU - Samaras, Dimitrios AU - Samaras D FAU - Frangos, Emilia AU - Frangos E FAU - Forster, Alexandre AU - Forster A FAU - Philippe, Jacques AU - Philippe J LA - eng PT - Journal Article PT - Review PL - United States TA - Rejuvenation Res JT - Rejuvenation research JID - 101213381 RN - 459AG36T1B (Dehydroepiandrosterone) SB - IM MH - Aging/*metabolism MH - Dehydroepiandrosterone/*metabolism MH - Humans MH - Syndrome PMC - PMC3746247 EDAT- 2013/05/08 06:00 MHDA- 2014/05/06 06:00 PMCR- 2014/08/01 CRDT- 2013/05/08 06:00 PHST- 2013/05/08 06:00 [entrez] PHST- 2013/05/08 06:00 [pubmed] PHST- 2014/05/06 06:00 [medline] PHST- 2014/08/01 00:00 [pmc-release] AID - 10.1089/rej.2013.1425 [pii] AID - 10.1089/rej.2013.1425 [doi] PST - ppublish SO - Rejuvenation Res. 2013 Aug;16(4):285-94. doi: 10.1089/rej.2013.1425. PMID- 31799297 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2307-8960 (Print) IS - 2307-8960 (Electronic) IS - 2307-8960 (Linking) VI - 7 IP - 22 DP - 2019 Nov 26 TI - Super-selective arterial embolization in the control of acute lower gastrointestinal hemorrhage. PG - 3728-3733 LID - 10.12998/wjcc.v7.i22.3728 [doi] AB - BACKGROUND: Acute gastrointestinal bleeding is an emergency condition that can lead to significant morbidity and mortality. Embolization is considered the preferred therapy in the treatment of lower gastrointestinal bleeding when it is unrealistic to perform the surgery or vasopressin infusion in this population. Treatment of acute lower gastrointestinal (GI) bleeding (any site below the ligament of Treitz) using this technique has not reached a consensus, because of the belief that the risk of intestinal infarction in this condition is extremely high. The purpose of the study is to evaluate the effectiveness and safety of this technique in a retrospective group of patients who underwent embolization for acute lower GI bleeding. AIM: To evaluate the efficacy and safety of super-selective arterial embolization in the management of acute lower GI bleeding. METHODS: A series of 31 consecutive patients with angiographically demonstrated small intestinal or colonic bleeding was retrospectively reviewed. The success rate and complication rate of super-selective embolization were recorded. RESULTS: Five out of thirty-one patients (16.1%) could not achieve sufficiently selective catheterization to permit embolization. Initial control of bleeding was achieved in 26 patients (100%), and relapsed GI bleeding occurred in 1 of them at 1 wk after the operation. No clinically apparent bowel infarctions were observed in patients undergoing embolization. CONCLUSION: Super-selective embolization is a safe therapeutic method for acute lower GI bleeding, and it is suitable and effective for many patients suffering this disease. Importantly, careful technique and suitable embolic agent are essential to the successful operation. CI - ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Lv, Liang-Shan AU - Lv LS AD - Department of Gastroenterology and Interventional Radiography, Xi'an Gaoxin Hospital, Xi'an Jiaotong University, Xi'an 710075, Shaanxi Province, China. 1603014227@st.nuc.edu.cn. FAU - Gu, Jing-Tao AU - Gu JT AD - Department of Vascular Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China. LA - eng PT - Journal Article PL - United States TA - World J Clin Cases JT - World journal of clinical cases JID - 101618806 PMC - PMC6887619 OTO - NOTNLM OT - Bowel OT - Embolization OT - Hemorrhage OT - Infarction OT - Lower gastrointestinal bleeding OT - Selective arterial embolization COIS- Conflict-of-interest statement: This research did not use any statistical method to analyze the data. EDAT- 2019/12/05 06:00 MHDA- 2019/12/05 06:01 PMCR- 2019/11/26 CRDT- 2019/12/05 06:00 PHST- 2019/09/08 00:00 [received] PHST- 2019/11/14 00:00 [revised] PHST- 2019/11/15 00:00 [accepted] PHST- 2019/12/05 06:00 [entrez] PHST- 2019/12/05 06:00 [pubmed] PHST- 2019/12/05 06:01 [medline] PHST- 2019/11/26 00:00 [pmc-release] AID - 10.12998/wjcc.v7.i22.3728 [doi] PST - ppublish SO - World J Clin Cases. 2019 Nov 26;7(22):3728-3733. doi: 10.12998/wjcc.v7.i22.3728. PMID- 35405423 OWN - NLM STAT- MEDLINE DCOM- 20220524 LR - 20220524 IS - 1879-0291 (Electronic) IS - 0141-1136 (Linking) VI - 177 DP - 2022 May TI - Behaviour broadens thermal safety margins on artificial coastal defences in the tropics. PG - 105618 LID - S0141-1136(22)00063-0 [pii] LID - 10.1016/j.marenvres.2022.105618 [doi] AB - Tropical species are predicted to be among the most vulnerable to climate change as they often live close to their upper limits to thermal tolerance and in many cases, behavioural thermoregulation is required to persist in the thermal extremes of tropical latitudes. In concert with warming temperatures, near-shore species are faced with the additional threat of shoreline hardening, leading to a reduction in microhabitats that can provide thermal refuges. This situation is exemplified in Singapore, which lies almost on the equator and so experiences year-round hot temperatures, and much of its coastline is now seawall. To investigate the thermal ecology of a common intertidal gastropod, Nerita undata, on these artificial structures, we measured thermal conditions on two seawalls, the temperatures of habitats occupied by the snail, and compared these with the snail's thermal tolerance by measuring heart rate and behavioural thermoregulation (as preferred temperature, Tpref). At one of the two seawalls (Tanjong Rimau), temperatures experienced by N. undata exceeded all measures of thermal tolerance in the sun, while at the other (Palawan Beach), they did not. Temperatures in habitats occupied by the snails on the seawalls were similar to their measured Tpref in the laboratory and were lower than all measures of thermal tolerance. Behavioural thermoregulation by the snails, therefore, significantly increased the thermal safety margins of N. undata on the relatively homogenous seawalls in Singapore, and at one of the two seawalls were necessary to allow snails to survive. Accordingly, to facilitate motile species to maintain broad thermal safety margins through behavioural regulation, the provision of additional refuges from thermal stress is recommended on artificial coastal defences such as seawalls. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Chan, Shelley H M AU - Chan SHM AD - Experimental Marine Ecology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117557, Singapore. FAU - Ong, Denise R Y AU - Ong DRY AD - Experimental Marine Ecology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117557, Singapore. FAU - Williams, Gray A AU - Williams GA AD - The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China. FAU - Crickenberger, Sam AU - Crickenberger S AD - The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China. FAU - Loke, Lynette H L AU - Loke LHL AD - Experimental Marine Ecology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117557, Singapore. FAU - Todd, Peter A AU - Todd PA AD - Experimental Marine Ecology Laboratory, Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, 117557, Singapore. Electronic address: dbspat@nus.edu.sg. LA - eng PT - Journal Article DEP - 20220405 PL - England TA - Mar Environ Res JT - Marine environmental research JID - 9882895 SB - IM MH - Animals MH - *Climate Change MH - Ecosystem MH - Hot Temperature MH - *Snails MH - Temperature OTO - NOTNLM OT - Complexity OT - Eco-engineering OT - Habitat enhancement OT - Nerita undata OT - Preferred temperature OT - Seawalls OT - Singapore EDAT- 2022/04/12 06:00 MHDA- 2022/05/25 06:00 CRDT- 2022/04/11 20:12 PHST- 2021/10/08 00:00 [received] PHST- 2022/03/31 00:00 [revised] PHST- 2022/04/03 00:00 [accepted] PHST- 2022/04/12 06:00 [pubmed] PHST- 2022/05/25 06:00 [medline] PHST- 2022/04/11 20:12 [entrez] AID - S0141-1136(22)00063-0 [pii] AID - 10.1016/j.marenvres.2022.105618 [doi] PST - ppublish SO - Mar Environ Res. 2022 May;177:105618. doi: 10.1016/j.marenvres.2022.105618. Epub 2022 Apr 5. PMID- 16051115 OWN - NLM STAT- MEDLINE DCOM- 20051228 LR - 20161222 IS - 1547-5271 (Print) IS - 1547-5271 (Linking) VI - 2 IP - 8 DP - 2005 Aug TI - Cardioverter-defibrillator implantation in high-risk patients with hypertrophic cardiomyopathy. PG - 814-9 AB - BACKGROUND: Implantable cardioverter-defibrillators (ICDs) are used with increasing frequency in hypertrophic cardiomyopathy (HCM) patients of all ages for primary and secondary sudden death prevention. Concerns may arise regarding the safety of device implantation because of unique clinical and phenotypic expressions of HCM. OBJECTIVES: The purpose of this study was to assess the efficacy and safety of ICD placement in high-risk patients with HCM. METHODS: We analyzed the experience with ICDs and transvenous lead systems in 75 consecutive HCM patients at the Minneapolis Heart Institute from 1993 to 2004. RESULTS: The age of the study group patients was 12 to 79 years (mean 36 +/- 16). Patients received ICDs for secondary (n = 4, after cardiac arrest) or primary prevention (n = 71, with > or = 1 risk factor). Thirty-one patients demonstrated disease features that potentially impacted methodology and safety of the implant procedure, most commonly massive left ventricular (LV) hypertrophy and outflow obstruction > or = 50 mmHg. There were no procedure-related deaths; defibrillator implants were successful and uneventful in 71 of 75 patients (95%). In 3 of the 75 patients (4%), defibrillation was unsuccessful because of high thresholds, associated with extreme hypertrophy (wall thickness > 45 mm) and/or ongoing amiodarone therapy. In two of these patients, thoracotomy with epicardial lead placement achieved successful defibrillation; ICD therapy was abandoned in the other patient. CONCLUSION: ICD placement in children and adults with HCM is generally safe and effective. However, in some patients with massive LV hypertrophy and/or prior administration of amiodarone, transvenous defibrillation proved difficult, and epicardial lead placement was required. High-energy ICD devices and defibrillation threshold testing are recommended for most high-risk HCM patients. FAU - Almquist, Adrian K AU - Almquist AK AD - Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota 55407, USA. FAU - Montgomery, Julia V AU - Montgomery JV FAU - Haas, Tammy S AU - Haas TS FAU - Maron, Barry J AU - Maron BJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Heart Rhythm JT - Heart rhythm JID - 101200317 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Cardiac Pacing, Artificial MH - Cardiomyopathy, Hypertrophic/diagnostic imaging/*therapy MH - Child MH - Cross-Sectional Studies MH - Death, Sudden, Cardiac/*prevention & control MH - *Defibrillators, Implantable/adverse effects MH - Female MH - Humans MH - Male MH - Middle Aged MH - Prosthesis Implantation/adverse effects MH - Risk Assessment MH - Risk Factors MH - Safety MH - Treatment Outcome MH - Ultrasonography EDAT- 2005/07/30 09:00 MHDA- 2005/12/29 09:00 CRDT- 2005/07/30 09:00 PHST- 2005/02/23 00:00 [received] PHST- 2005/05/10 00:00 [accepted] PHST- 2005/07/30 09:00 [pubmed] PHST- 2005/12/29 09:00 [medline] PHST- 2005/07/30 09:00 [entrez] AID - S1547-5271(05)01652-8 [pii] AID - 10.1016/j.hrthm.2005.05.008 [doi] PST - ppublish SO - Heart Rhythm. 2005 Aug;2(8):814-9. doi: 10.1016/j.hrthm.2005.05.008. PMID- 8504382 OWN - NLM STAT- MEDLINE DCOM- 19930702 LR - 20051116 IS - 0749-0690 (Print) IS - 0749-0690 (Linking) VI - 9 IP - 2 DP - 1993 May TI - Seizure disorders, diabetes mellitus, and cerebrovascular disease. Considerations for older drivers. PG - 323-39 AB - For those conditions in which loss of consciousness is the main issue, such as epilepsy, factors that contribute to risk of seizure recurrence are central to the determination of driver safety. Thus, high- and low-risk groups may be identified and factors that contribute to high risk checked. These factors also serve to develop a program to reduce such risk in the future. In the population with seizure disorders, young males under age 25 have the highest risk for traffic accidents and violations. Other factors associated with high risk are partial complex seizure type, history of drug toxicity with anticonvulsant medications, alcohol abuse or poor compliance for medications, and history of psychiatric illness. For conditions such as cerebrovascular accidents or Parkinson's disease, the recognition of the diagnosis alone is insufficient to determine driver competence. In these illnesses, the task is to recognize levels of failure of individual skills and function that specifically render a person incompetent for safe driving. Such a precise determination is currently not possible in individuals with cerebrovascular accidents or other forms of brain injury (e.g., trauma) or degenerative brain disease (e.g., Parkinson's disease). There is intuitive and general agreement that there are those so severely affected that driving has become impossible or very dangerous. Alternately, there are also those with these conditions whose driving skills and competence are virtually unaffected and pose no risk to traffic safety. Physicians vary widely in their ability and experience in judging the competence and safety of those in between these two extremes. For this reason, a standardized approach is essential both to ensure the avoidance of unnecessary bias as well as to ensure the safety of the driver and the general public. At some time in the future when all the necessary driving skills are identified and appropriate tests are developed to judge them, a battery of tests for the elderly at age 65 and at regular intervals thereafter may be used. Until then, some form of clinical judgment and legal regulation may have to be adopted. One option would be to adopt a rule similar to that in the United Kingdom where all persons with TIAs or cerebrovascular accidents would automatically suspend driving for 3 months because of the high risk for recurrence of both cerebrovascular as well as ischemic heart disease in that interval.(ABSTRACT TRUNCATED AT 400 WORDS) FAU - Hansotia, P AU - Hansotia P AD - Department of Neurology, Marshfield Clinic, Wisconsin. LA - eng PT - Journal Article PT - Review PL - United States TA - Clin Geriatr Med JT - Clinics in geriatric medicine JID - 8603766 SB - IM MH - Accidents, Traffic MH - Adult MH - *Aged MH - *Automobile Driving MH - *Cerebrovascular Disorders MH - *Diabetes Mellitus MH - Humans MH - Middle Aged MH - *Seizures RF - 42 EDAT- 1993/05/01 00:00 MHDA- 1993/05/01 00:01 CRDT- 1993/05/01 00:00 PHST- 1993/05/01 00:00 [pubmed] PHST- 1993/05/01 00:01 [medline] PHST- 1993/05/01 00:00 [entrez] PST - ppublish SO - Clin Geriatr Med. 1993 May;9(2):323-39. PMID- 24760371 OWN - NLM STAT- MEDLINE DCOM- 20150821 LR - 20211021 IS - 1432-1254 (Electronic) IS - 0020-7128 (Linking) VI - 59 IP - 3 DP - 2015 Mar TI - The influence of weather on health-related help-seeking behavior of senior citizens in Hong Kong. PG - 373-6 LID - 10.1007/s00484-014-0831-7 [doi] AB - It is believed that extreme hot and cold weather has a negative impact on general health conditions. Much research focuses on mortality, but there is relatively little community health research. This study is aimed at identifying high-risk groups who are sensitive to extreme weather conditions, in particular, very hot and cold days, through an analysis of the health-related help-seeking patterns of over 60,000 Personal Emergency Link (PE-link) users in Hong Kong relative to weather conditions. In the study, 1,659,716 PE-link calls to the help center were analyzed. Results showed that females, older elderly, people who did not live alone, non-subsidized (relatively high-income) users, and those without medical histories of heart disease, hypertension, stroke, and diabetes were more sensitive to extreme weather condition. The results suggest that using official government weather forecast reports to predict health-related help-seeking behavior is feasible. An evidence-based strategic plan could be formulated by using a method similar to that used in this study to identify high-risk groups. Preventive measures could be established for protecting the target groups when extreme weather conditions are forecasted. FAU - Wong, Ho Ting AU - Wong HT AD - Department of Social Work, Hong Kong Baptist University, Hong Kong, SAR, China, frankwong@connect.hku.hk. FAU - Chiu, Marcus Yu Lung AU - Chiu MY FAU - Wu, Cynthia Sau Ting AU - Wu CS FAU - Lee, Tsz Cheung AU - Lee TC CN - Senior Citizen Home Safety Association LA - eng PT - Journal Article DEP - 20140424 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - Aged MH - Aged, 80 and over MH - Air Pressure MH - Female MH - *Health Behavior MH - Health Services Needs and Demand MH - Hong Kong/epidemiology MH - Hospitalization/statistics & numerical data MH - Humans MH - Humidity MH - Male MH - Telemedicine MH - Temperature EDAT- 2014/04/25 06:00 MHDA- 2015/08/22 06:00 CRDT- 2014/04/25 06:00 PHST- 2014/01/07 00:00 [received] PHST- 2014/04/05 00:00 [accepted] PHST- 2014/04/03 00:00 [revised] PHST- 2014/04/25 06:00 [entrez] PHST- 2014/04/25 06:00 [pubmed] PHST- 2015/08/22 06:00 [medline] AID - 10.1007/s00484-014-0831-7 [doi] PST - ppublish SO - Int J Biometeorol. 2015 Mar;59(3):373-6. doi: 10.1007/s00484-014-0831-7. Epub 2014 Apr 24. PMID- 37895802 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231030 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 16 IP - 20 DP - 2023 Oct 23 TI - Surface Protection Technology for Metallic Materials in Marine Environments. LID - 10.3390/ma16206822 [doi] LID - 6822 AB - As the demand for the development and utilization of marine resources continues to strengthen, the service requirements for advanced marine equipment are rapidly increasing. Surface protection technology has become an important way of solving the tribological problems of extreme operating conditions and improving the safety performance of equipment by imparting certain special properties to the surface of the material through physical, chemical or mechanical processes to enhance the ability of the material to withstand external environmental factors. Combined with the extremely complex characteristics of the marine environment, this paper describes the commonly used surface protection technologies for metal materials in the marine environment. Research on surface texture was summarized under different surface reshaping technologies, as well as processes and coating materials under different surface modification technologies. Combined with the existing research progress and development trends of marine metallic materials, the surfaces of metal materials under the marine environment protection technology foreground are prospected and provide a reference for the improvement of equipment performance in extreme marine environments. FAU - Xu, Jing AU - Xu J AUID- ORCID: 0000-0003-0327-7446 AD - School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. FAU - Lu, Hao AU - Lu H AD - School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. FAU - Cai, Linxuan AU - Cai L AD - School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. FAU - Liao, Yihong AU - Liao Y AD - School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China. FAU - Lian, Jiadi AU - Lian J AD - Department of Mechanical Engineering, China Jiliang University, Hangzhou 310018, China. LA - eng GR - No. 52275182/the National Nature Science Foundation of China/ GR - No. GK229909299001-14/the Fundamental Research Funds for the Provincial Universities of Zhejiang, China/ GR - No. LTGS23E060002/Nature Science Foundation of Zhejiang Province, China/ GR - No. SKLTKF22B02/The Tribology Science Fund of State Key Laboratory of Tribology in Advanced Equipment/ PT - Journal Article PT - Review DEP - 20231023 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC10608535 OTO - NOTNLM OT - abrasion OT - corrosion OT - erosion OT - marine environment OT - surface technology COIS- The authors declare no conflict of interest. EDAT- 2023/10/28 11:44 MHDA- 2023/10/28 11:45 PMCR- 2023/10/23 CRDT- 2023/10/28 01:23 PHST- 2023/09/13 00:00 [received] PHST- 2023/10/19 00:00 [revised] PHST- 2023/10/20 00:00 [accepted] PHST- 2023/10/28 11:45 [medline] PHST- 2023/10/28 11:44 [pubmed] PHST- 2023/10/28 01:23 [entrez] PHST- 2023/10/23 00:00 [pmc-release] AID - ma16206822 [pii] AID - materials-16-06822 [pii] AID - 10.3390/ma16206822 [doi] PST - epublish SO - Materials (Basel). 2023 Oct 23;16(20):6822. doi: 10.3390/ma16206822. PMID- 38543210 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240330 IS - 1999-4923 (Print) IS - 1999-4923 (Electronic) IS - 1999-4923 (Linking) VI - 16 IP - 3 DP - 2024 Feb 23 TI - Evaluation of the Stability of Newborn Hospital Parenteral Nutrition Solutions. LID - 10.3390/pharmaceutics16030316 [doi] LID - 316 AB - (1) Background: parenteral nutrition (PN) solutions are an extremely complex mixture. It is composed of a multitude of chemical elements that can give rise to a large number of interactions that condition its stability and safety. The aim of this study was to evaluate the stability of PN solutions for preterm infants. (2) Methods: eight samples were prepared according to the protocol for prescribing PN in preterm infants. Samples PN1-PN7 had the normal progression of macronutrients and standard amounts of micronutrients for a 1 kg preterm infant. The PN8 sample had a high concentration of electrolytes, with the idea of forcing stability limits. Samples were stored both at room temperature and under refrigeration. Measurements of globule size, pH, density, and viscosity were performed in both storage protocols on different days after processing. (3) Results: the changes in the composition of the samples did not affect the evolution of the stability at the different measurement times and temperatures. Viscosity was affected by the compositional changes made in the PN samples, but no alterations due to time or temperature were observed. Density and pH remained stable, without significant changes due to time, storage temperature, or different composition. (4) Conclusion: all samples remained stable during the study period and did not undergo significant alterations due to compositional changes or different experimental conditions. FAU - Otero-Millán, Luis AU - Otero-Millán L AD - Pharmacy Department, University Hospital Complex of Vigo, 36312 Vigo, Spain. AD - NeumoVigo I+i Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain. FAU - Bea-Mascato, Brais AU - Bea-Mascato B AD - Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain. FAU - Legido Soto, Jose Luis AU - Legido Soto JL AD - Applied Physic Department, Faculty of Sciences, University of Vigo, 36310 Vigo, Spain. FAU - Martínez-López-De-Castro, Noemi AU - Martínez-López-De-Castro N AD - Pharmacy Department, University Hospital Complex of Vigo, 36312 Vigo, Spain. AD - Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain. FAU - Lago-Rivero, Natividad AU - Lago-Rivero N AUID- ORCID: 0000-0002-3695-4864 AD - Pharmacy Department, University Hospital Complex of Vigo, 36312 Vigo, Spain. AD - Innovation in Clinical Pharmacy Research Group (i-FARMA-Vigo), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain. LA - eng PT - Journal Article DEP - 20240223 PL - Switzerland TA - Pharmaceutics JT - Pharmaceutics JID - 101534003 PMC - PMC10975575 OTO - NOTNLM OT - critical care OT - parenteral nutrition OT - pediatric nutrition OT - physico-chemical stability COIS- The authors declare no conflicts of interest. EDAT- 2024/03/28 06:45 MHDA- 2024/03/28 06:46 PMCR- 2024/02/23 CRDT- 2024/03/28 01:23 PHST- 2024/01/11 00:00 [received] PHST- 2024/02/17 00:00 [revised] PHST- 2024/02/21 00:00 [accepted] PHST- 2024/03/28 06:46 [medline] PHST- 2024/03/28 06:45 [pubmed] PHST- 2024/03/28 01:23 [entrez] PHST- 2024/02/23 00:00 [pmc-release] AID - pharmaceutics16030316 [pii] AID - pharmaceutics-16-00316 [pii] AID - 10.3390/pharmaceutics16030316 [doi] PST - epublish SO - Pharmaceutics. 2024 Feb 23;16(3):316. doi: 10.3390/pharmaceutics16030316. PMID- 24564316 OWN - NLM STAT- MEDLINE DCOM- 20140918 LR - 20181202 IS - 1943-5681 (Electronic) IS - 0002-9645 (Linking) VI - 75 IP - 3 DP - 2014 Mar TI - Effects of weather variables on thermoregulation of calves during periods of extreme heat. PG - 296-300 LID - 10.2460/ajvr.75.3.296 [doi] AB - OBJECTIVE: To determine effects of ambient temperature, relative humidity, wind speed, relative barometric pressure, and temperature-humidity index (THI) on nasal submucosal and rectal temperatures in cattle during extreme summer conditions. ANIMALS: 20 black crossbred beef heifers (mean body weight, 217.8 kg). PROCEDURES: Nasal submucosal and rectal temperatures were monitored every 2 hours for 24 hours on 3 nonconsecutive days when ambient temperature was forecasted to exceed 32.2°C. Ambient temperature, relative humidity, wind speed, and relative barometric pressure were continuously monitored at a remote weather station located at the research facility. The THI was calculated and used in the livestock weather safety index (LWSI). Relationships between nasal submucosal or rectal temperature and weather variables were evaluated. RESULTS: Nasal submucosal and rectal temperatures were related to all weather variables monitored. A positive relationship was determined for ambient temperature and THI with both nasal submucosal and rectal temperatures. A negative relationship was evident for nasal submucosal and rectal temperature with relative humidity, wind speed, and relative barometric pressure. Nasal submucosal and rectal temperatures increased with increasing severity of LWSI category. CONCLUSIONS AND CLINICAL RELEVANCE: Effects of environmental conditions on thermoregulation in calves exposed to extreme heat were detected. The positive relationship between nasal submucosal temperature and ambient temperature and THI raised concerns about the efficacy of intranasal administration of temperature-sensitive modified-live virus vaccines during periods of extreme heat. Environmental conditions must be considered when rectal temperature is used as a diagnostic tool for identifying morbid cattle. FAU - Theurer, Miles E AU - Theurer ME AD - Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506. FAU - Anderson, David E AU - Anderson DE FAU - White, Brad J AU - White BJ FAU - Miesner, Matt D AU - Miesner MD FAU - Larson, Robert L AU - Larson RL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Vet Res JT - American journal of veterinary research JID - 0375011 SB - IM MH - Animals MH - Body Temperature Regulation/*physiology MH - Cattle/*physiology MH - *Extreme Heat MH - Female MH - Humidity MH - Seasons MH - Time Factors MH - *Weather MH - Wind EDAT- 2014/02/26 06:00 MHDA- 2014/09/19 06:00 CRDT- 2014/02/26 06:00 PHST- 2014/02/26 06:00 [entrez] PHST- 2014/02/26 06:00 [pubmed] PHST- 2014/09/19 06:00 [medline] AID - 10.2460/ajvr.75.3.296 [doi] PST - ppublish SO - Am J Vet Res. 2014 Mar;75(3):296-300. doi: 10.2460/ajvr.75.3.296. PMID- 27229107 OWN - NLM STAT- MEDLINE DCOM- 20170615 LR - 20171030 IS - 1095-8673 (Electronic) IS - 0022-4804 (Linking) VI - 202 IP - 2 DP - 2016 May 15 TI - Risks of adverse events in colorectal patients: population-based study. PG - 328-34 LID - S0022-4804(16)00029-9 [pii] LID - 10.1016/j.jss.2016.01.013 [doi] AB - BACKGROUND: Postoperative (PO) outcomes are rapidly being integrated into value-based purchasing programs and associated penalties are slated for inclusion in the near future. Colorectal surgery procedures are extremely common and account for a high proportion of morbidity among general surgery. We sought to assess adverse events in colorectal surgical patients. METHODS: We performed a retrospective study using the Nationwide Inpatient Sample database, 2008-2012. Patients were identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes and classified based on procedure indication: colon cancer, benign polyps, diverticulitis, inflammatory bowel disease, and ischemic colitis. The outcome of interest was inpatient adverse event identified by Agency for Healthcare Research and Quality's patient safety indicators (PSIs). RESULTS: We identified 1,100,184 colorectal patients who underwent major surgery; 2.7% developed a PSI during their hospital stay. Compared to all colorectal patients, those with ischemic colitis had significantly higher risk-adjusted rates per 1000 case for pressure ulcer (50.20), failure to rescue (211.30), central line bloodstream infection (2.33) and PO DE/deep vein thrombosis (16.02), and sepsis (46.99), whereas benign polyps were associated with significantly lower risk-adjusted rates per 1000 cases for pressure ulcer (11.48), failure to rescue (84.79), central line bloodstream infection (0.97) and PO pulmonary embolism/deep vein thrombosis (4.81), and sepsis (11.23). Compared to both patient demographic and clinical characteristics, the procedure indication was the strongest predictor of any PSI relevant to colorectal surgery; patients with ischemic colitis had higher odds of experiencing a PSI (odds ratio, 1.84; 95% confidence interval, 1.71-1.99) compared with cancer patients. CONCLUSIONS: Among colorectal surgery patients, inpatient events were not uncommon. We found important differential rates of adverse events by diagnostic category, with the highest odds ratio occurring in patients undergoing surgery for ischemic colitis. Our work elaborates the need for rigorous risk adjustment, quality improvement strategies for high-risk populations, and attention to detail in calculating financial incentives in emerging value-based purchasing programs. CI - Copyright © 2016 Elsevier Inc. All rights reserved. FAU - Hernandez-Boussard, Tina M AU - Hernandez-Boussard TM AD - Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, California; Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California. Electronic address: Boussard@stanford.edu. FAU - McDonald, Kathryn M AU - McDonald KM AD - Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California. FAU - Morrison, Doug E AU - Morrison DE AD - Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, California. FAU - Rhoads, Kim F AU - Rhoads KF AD - Department of Surgery, Stanford School of Medicine, Stanford University, Stanford, California. LA - eng GR - K01 HS018558/HS/AHRQ HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, U.S. Gov't, P.H.S. DEP - 20160120 PL - United States TA - J Surg Res JT - The Journal of surgical research JID - 0376340 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Colonic Diseases/*surgery MH - *Colorectal Surgery MH - Databases, Factual MH - Female MH - Humans MH - Logistic Models MH - Male MH - Middle Aged MH - Patient Safety MH - Postoperative Complications/epidemiology/*etiology MH - Quality Indicators, Health Care MH - Rectal Diseases/*surgery MH - Retrospective Studies MH - Risk Adjustment MH - Risk Factors MH - United States MH - Young Adult OTO - NOTNLM OT - Adverse events OT - Colorectal surgery OT - Risk adjustment EDAT- 2016/05/28 06:00 MHDA- 2017/06/16 06:00 CRDT- 2016/05/28 06:00 PHST- 2015/09/11 00:00 [received] PHST- 2016/01/08 00:00 [revised] PHST- 2016/01/12 00:00 [accepted] PHST- 2016/05/28 06:00 [entrez] PHST- 2016/05/28 06:00 [pubmed] PHST- 2017/06/16 06:00 [medline] AID - S0022-4804(16)00029-9 [pii] AID - 10.1016/j.jss.2016.01.013 [doi] PST - ppublish SO - J Surg Res. 2016 May 15;202(2):328-34. doi: 10.1016/j.jss.2016.01.013. Epub 2016 Jan 20. PMID- 24463327 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20211021 IS - 1555-824X (Electronic) IS - 1062-8606 (Print) IS - 1062-8606 (Linking) VI - 30 IP - 2 DP - 2015 Mar-Apr TI - Impact of including readmissions for qualifying events in the patient safety indicators. PG - 114-8 LID - 10.1177/1062860613518341 [doi] AB - The Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) do not capture complications arising after discharge. This study sought to quantify the bias related to omission of readmissions for PSI-qualifying conditions. Using 2000-2009 California Office of Statewide Health Planning and Development Patient Discharge Data, the study team examined the change in PSI rates when including readmissions in the numerator, hospitals performing in the extreme deciles, and longitudinal performance. Including 7-day readmissions resulted in a 0.3% to 8.9% increase in average hospital PSI rates. Hospital PSI rates with and without PSI-qualifying 30-day readmissions were highly correlated for point estimates and within-hospital longitudinal change. Most hospitals remained in the same relative performance decile. Longer length of stay, public payer, and discharge to skilled nursing facilities were associated with a higher risk of readmission for a PSI-qualifying event. Failure to include readmissions in calculating PSIs is unlikely to lead to erroneous conclusions. CI - © 2014 by the American College of Medical Quality. FAU - Davies, Sheryl M AU - Davies SM AD - Stanford University, Stanford, CA smdavies@stanford.edu. FAU - Saynina, Olga AU - Saynina O AD - Stanford University, Stanford, CA. FAU - Baker, Laurence C AU - Baker LC AD - Stanford University, Stanford, CA. FAU - McDonald, Kathryn M AU - McDonald KM AD - Stanford University, Stanford, CA. LA - eng GR - P30 AG017253/AG/NIA NIH HHS/United States GR - AG017253/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140124 PL - Netherlands TA - Am J Med Qual JT - American journal of medical quality : the official journal of the American College of Medical Quality JID - 9300756 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - California MH - Databases, Factual MH - Female MH - Hospitals/standards MH - Humans MH - Male MH - Medical Errors MH - Middle Aged MH - *Patient Readmission MH - Patient Safety/*standards MH - *Quality Indicators, Health Care MH - Quality of Health Care/standards MH - United States MH - Young Adult PMC - PMC4452378 MID - NIHMS682619 OTO - NOTNLM OT - Patient Safety Indicators OT - hospital quality OT - quality metrics OT - readmissions EDAT- 2014/01/28 06:00 MHDA- 2016/12/15 06:00 PMCR- 2015/06/02 CRDT- 2014/01/28 06:00 PHST- 2014/01/28 06:00 [entrez] PHST- 2014/01/28 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] PHST- 2015/06/02 00:00 [pmc-release] AID - 1062860613518341 [pii] AID - 10.1177/1062860613518341 [doi] PST - ppublish SO - Am J Med Qual. 2015 Mar-Apr;30(2):114-8. doi: 10.1177/1062860613518341. Epub 2014 Jan 24. PMID- 39640390 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241206 IS - 2215-0161 (Print) IS - 2215-0161 (Electronic) IS - 2215-0161 (Linking) VI - 13 DP - 2024 Dec TI - Distributions conditioned on extrapolated events via copula and extreme value theory. PG - 103017 LID - 10.1016/j.mex.2024.103017 [doi] LID - 103017 AB - In an interaction between road users, the proximity and speed are two interdependent dimensions which can be captured by a type of multivariate distribution called Copula. Copula requires all marginal distribution functions to be known. However, finding the marginal distribution of the proximity dimension is challenging, as its histogram usually contains several peaks. We partition the outcome space in a way that extreme value theory can be used as a tool to approximate the target marginal distribution in the tail region. In traffic safety research, such approach has the following advantages:•The approach can approximate the distribution in the region in which the density is monotone.•Via copula and extreme value theory, it is possible to find the conditional distribution while the conditions are not present in the data set. CI - © 2024 The Authors. FAU - Chen, Zhankun AU - Chen Z AD - Department of Technology & Society, Lund University, Lund, 221 00, Sweden. FAU - Johnsson, Carl AU - Johnsson C AD - Department of Technology & Society, Lund University, Lund, 221 00, Sweden. FAU - D'Agostino, Carmelo AU - D'Agostino C AD - Department of Technology & Society, Lund University, Lund, 221 00, Sweden. LA - eng PT - Journal Article DEP - 20241028 PL - Netherlands TA - MethodsX JT - MethodsX JID - 101639829 PMC - PMC11617690 OTO - NOTNLM OT - Copula OT - Extreme value theory OT - Traffic safety COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/06 06:24 MHDA- 2024/12/06 06:25 PMCR- 2024/10/28 CRDT- 2024/12/06 04:51 PHST- 2024/08/09 00:00 [received] PHST- 2024/10/22 00:00 [accepted] PHST- 2024/12/06 06:25 [medline] PHST- 2024/12/06 06:24 [pubmed] PHST- 2024/12/06 04:51 [entrez] PHST- 2024/10/28 00:00 [pmc-release] AID - S2215-0161(24)00468-0 [pii] AID - 103017 [pii] AID - 10.1016/j.mex.2024.103017 [doi] PST - epublish SO - MethodsX. 2024 Oct 28;13:103017. doi: 10.1016/j.mex.2024.103017. eCollection 2024 Dec. PMID- 23928504 OWN - NLM STAT- MEDLINE DCOM- 20140707 LR - 20220331 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 60 DP - 2013 Nov TI - Explaining the road accident risk: weather effects. PG - 456-65 LID - S0001-4575(13)00094-8 [pii] LID - 10.1016/j.aap.2013.03.006 [doi] AB - This research aims to highlight the link between weather conditions and road accident risk at an aggregate level and on a monthly basis, in order to improve road safety monitoring at a national level. It is based on some case studies carried out in Work Package 7 on "Data analysis and synthesis" of the EU-FP6 project "SafetyNet-Building the European Road Safety Observatory", which illustrate the use of weather variables for analysing changes in the number of road injury accidents. Time series analysis models with explanatory variables that measure the weather quantitatively were used and applied to aggregate datasets of injury accidents for France, the Netherlands and the Athens region, over periods of more than 20 years. The main results reveal significant correlations on a monthly basis between weather variables and the aggregate number of injury accidents, but the magnitude and even the sign of these correlations vary according to the type of road (motorways, rural roads or urban roads). Moreover, in the case of the interurban network in France, it appears that the rainfall effect is mainly direct on motorways--exposure being unchanged, and partly indirect on main roads--as a result of changes in exposure. Additional results obtained on a daily basis for the Athens region indicate that capturing the within-the-month variability of the weather variables and including it in a monthly model highlights the effects of extreme weather. Such findings are consistent with previous results obtained for France using a similar approach, with the exception of the negative correlation between precipitation and the number of injury accidents found for the Athens region, which is further investigated. The outlook for the approach and its added value are discussed in the conclusion. CI - Copyright © 2013. Published by Elsevier Ltd. FAU - Bergel-Hayat, Ruth AU - Bergel-Hayat R AD - UPE IFSTTAR GRETTIA, French Institute of Science and Technology for Transport, Development and Networks, France. Electronic address: ruth.bergel@ifsttar.fr. FAU - Debbarh, Mohammed AU - Debbarh M FAU - Antoniou, Constantinos AU - Antoniou C FAU - Yannis, George AU - Yannis G LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130401 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/prevention & control/*statistics & numerical data MH - France/epidemiology MH - Greece/epidemiology MH - Humans MH - Models, Statistical MH - Netherlands/epidemiology MH - Risk Assessment MH - Risk Factors MH - *Safety MH - Seasons MH - Time Factors MH - *Weather MH - Wounds and Injuries/epidemiology/etiology OTO - NOTNLM OT - Aggregate risk OT - Athens region OT - France OT - Frost OT - Injury accidents OT - Precipitation OT - Rainfall OT - Road safety OT - Temperature OT - The Netherlands OT - Weather effects EDAT- 2013/08/10 06:00 MHDA- 2014/07/08 06:00 CRDT- 2013/08/10 06:00 PHST- 2011/11/16 00:00 [received] PHST- 2012/10/11 00:00 [revised] PHST- 2013/03/05 00:00 [accepted] PHST- 2013/08/10 06:00 [entrez] PHST- 2013/08/10 06:00 [pubmed] PHST- 2014/07/08 06:00 [medline] AID - S0001-4575(13)00094-8 [pii] AID - 10.1016/j.aap.2013.03.006 [doi] PST - ppublish SO - Accid Anal Prev. 2013 Nov;60:456-65. doi: 10.1016/j.aap.2013.03.006. Epub 2013 Apr 1. PMID- 31512718 OWN - NLM STAT- MEDLINE DCOM- 20200615 LR - 20200615 IS - 1554-6578 (Electronic) IS - 0022-3069 (Linking) VI - 78 IP - 11 DP - 2019 Nov 1 TI - Novel Spiroplasma sp. Isolated From CWD Is an Extreme Bacterial Thermoacidophile That Survives Autoclaving, Boiling, Formalin Treatment, and Significant Gamma Irradiation. PG - 993-1001 LID - 10.1093/jnen/nlz081 [doi] AB - Rapid spreading of chronic wasting disease (CWD) in wildlife and captive cervid populations has exposed lack of progress in dealing with the transmissible spongiform encephalopathies (TSE) of man and animals. Since the TSE transmissible agent was resistant to extremes in environmental and chemical treatments, focus was on an unconventional agent including the prion theory. Recent breakthrough research has revealed consistent isolation of a novel Spiroplasma sp. from TSE-affected tissues that propagates in cell-free media and on agar. Here, we developed a live culture assay to test whether the CWD spiroplasma isolate possessed unconventional biologic properties akin to those of the transmissible agent of TSE. The CWD spiroplasma isolate survived boiling for 1 hour, standard liquid autoclaving, 10% formalin treatment overnight, and gamma irradiation of 20 kGy. The CWD spiroplasma isolate is an acidophile, growing best at pH 2. The biologic resistance of the CWD spiroplasma isolate may be due to unusual phage-like viruses found in the bacterial pellet or to DNA-protein binding. Because the CWD spiroplasma isolate has biologic properties consistent with the causal agent of the TSEs, TSE research focus should be redirected to development of diagnostic tests and preventive vaccines for control of CWD based upon the bacterium. CI - © 2019 American Association of Neuropathologists, Inc. All rights reserved. FAU - Bastian, Frank O AU - Bastian FO AD - Bastian Laboratory for Neurological Disease Research, New Orleans, Louisiana. AD - Texas Tech University, Department of Environmental Toxicology, Lubbock, Texas. AD - Tulane Medical School Department of Pathology, New Orleans, Louisiana. FAU - Lynch, James AU - Lynch J AD - Bastian Laboratory for Neurological Disease Research, New Orleans, Louisiana. FAU - Wang, Wei-Hsung AU - Wang WH AD - Radiation Safety Office/Center for Energy Studies, Louisiana State University, Louisiana. LA - eng PT - Journal Article PL - England TA - J Neuropathol Exp Neurol JT - Journal of neuropathology and experimental neurology JID - 2985192R RN - 0 (Anti-Bacterial Agents) RN - 1HG84L3525 (Formaldehyde) SB - IM MH - Animals MH - Animals, Wild/microbiology MH - Anti-Bacterial Agents/administration & dosage MH - Cells, Cultured MH - Formaldehyde/administration & dosage MH - Gamma Rays MH - Prion Diseases/*microbiology MH - Spiroplasma/*isolation & purification/*pathogenicity/ultrastructure MH - Wasting Disease, Chronic/*microbiology OTO - NOTNLM OT - Chronic wasting disease OT - Creutzfeldt Jacob disease OT - Drop assay OT - Gamma irradiation OT - Prion OT - Scrapie OT - Thermoacidophile EDAT- 2019/09/13 06:00 MHDA- 2020/06/17 06:00 CRDT- 2019/09/13 06:00 PHST- 2019/05/11 00:00 [received] PHST- 2019/07/12 00:00 [revised] PHST- 2019/08/05 00:00 [accepted] PHST- 2019/09/13 06:00 [pubmed] PHST- 2020/06/17 06:00 [medline] PHST- 2019/09/13 06:00 [entrez] AID - 5568265 [pii] AID - 10.1093/jnen/nlz081 [doi] PST - ppublish SO - J Neuropathol Exp Neurol. 2019 Nov 1;78(11):993-1001. doi: 10.1093/jnen/nlz081. PMID- 27402077 OWN - NLM STAT- MEDLINE DCOM- 20170901 LR - 20181202 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 16 DP - 2016 Jul 11 TI - Workers' perceptions of climate change related extreme heat exposure in South Australia: a cross-sectional survey. PG - 549 LID - 10.1186/s12889-016-3241-4 [doi] LID - 549 AB - BACKGROUND: Occupational exposure to extreme heat without sufficient protection may not only increase the risk of heat-related illnesses and injuries but also compromise economic productivity. With predictions of more frequent and intense bouts of hot weather, workplace heat exposure is presenting a growing challenge to workers' health and safety. This study aims to investigate workers' perceptions and behavioural responses towards extreme heat exposure in a warming climate. METHODS: A cross-sectional questionnaire survey was conducted in 2012 in South Australia among selected outdoor industries. Workers' heat risk perceptions were measured in the following five aspects: concerns about heat exposure, attitudes towards more training, policy and guideline support, the adjustment of work habits, and degree of satisfaction of current preventive measures. Bivariate and multivariate logistic regression analyses were used to identify factors significantly associated with workers' heat perceptions. RESULTS: A total of 749 respondents participated in this survey, with a response rate of 50.9 %. A little more than half (51.2 %) of respondents were moderately or very much concerned about workplace heat exposure. Factors associated with workers' heat concerns included age, undertaking very physically demanding work, and the use of personal protective equipment, heat illness history, and injury experience during hot weather. Less than half (43.4 %) of the respondents had received heat-related training. Workers aged 25-54 years and those with previous heat-related illness/injury history showed more supportive attitudes towards heat-related training. The provision of cool drinking water was the most common heat prevention measure. A little more than half (51.4 %) of respondents were satisfied with the current heat prevention measures. About two-thirds (63.8 %) of respondents agreed that there should be more heat-related regulations and guidelines for working during very hot weather. More than two-thirds (68.8 %) of the respondents were willing to adjust their current work habits to adapt to the likely increasing extreme heat, especially those with previous heat illness experience. CONCLUSIONS: The findings suggest a need to strengthen workers' heat risk awareness and refine current heat prevention strategies in a warming climate. Further heat educational programmes and training should focus on those undertaking physically demanding work outdoors, in particular young workers and those over 55 years with low education levels. FAU - Xiang, Jianjun AU - Xiang J AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. AD - Department of Emergency Response and Preparedness, Fujian Provincial Center for Disease Control and Prevention, Fuzhou, 350001, China. FAU - Hansen, Alana AU - Hansen A AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. FAU - Pisaniello, Dino AU - Pisaniello D AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. FAU - Bi, Peng AU - Bi P AD - School of Public Health, The University of Adelaide, Adelaide, 5005, SA, Australia. peng.bi@adelaide.edu.au. LA - eng PT - Journal Article DEP - 20160711 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adult MH - Age Factors MH - *Climate Change MH - Cross-Sectional Studies MH - Extreme Heat/*adverse effects MH - Female MH - Heat Stress Disorders/*prevention & control/psychology MH - Humans MH - Male MH - Middle Aged MH - Occupational Exposure/legislation & jurisprudence/*statistics & numerical data MH - Occupational Health/legislation & jurisprudence/*statistics & numerical data MH - Safety MH - South Australia MH - Workplace/legislation & jurisprudence/*psychology/statistics & numerical data MH - Young Adult PMC - PMC4940878 OTO - NOTNLM OT - Climate change OT - Heat stress OT - Perceptions OT - Work-related injuries OT - Workplace heat exposure EDAT- 2016/07/13 06:00 MHDA- 2017/09/02 06:00 PMCR- 2016/07/11 CRDT- 2016/07/13 06:00 PHST- 2016/01/08 00:00 [received] PHST- 2016/06/15 00:00 [accepted] PHST- 2016/07/13 06:00 [entrez] PHST- 2016/07/13 06:00 [pubmed] PHST- 2017/09/02 06:00 [medline] PHST- 2016/07/11 00:00 [pmc-release] AID - 10.1186/s12889-016-3241-4 [pii] AID - 3241 [pii] AID - 10.1186/s12889-016-3241-4 [doi] PST - epublish SO - BMC Public Health. 2016 Jul 11;16:549. doi: 10.1186/s12889-016-3241-4. PMID- 33902323 OWN - NLM STAT- MEDLINE DCOM- 20211217 LR - 20240403 IS - 1556-7125 (Electronic) IS - 1535-3141 (Print) IS - 1535-3141 (Linking) VI - 18 IP - 8 DP - 2021 Aug TI - High-Efficiency Machine Learning Method for Identifying Foodborne Disease Outbreaks and Confounding Factors. PG - 590-598 LID - 10.1089/fpd.2020.2913 [doi] AB - The China National Center for Food Safety Risk Assessment (CFSA) uses the Foodborne Disease Monitoring and Reporting System (FDMRS) to monitor outbreaks of foodborne diseases across the country. However, there are problems of underreporting or erroneous reporting in FDMRS, which significantly increase the cost of related epidemic investigations. To solve this problem, we designed a model to identify suspected outbreaks from the data generated by the FDMRS of CFSA. In this study, machine learning models were used to fit the data. The recall rate and F1-score were used as evaluation metrics to compare the classification performance of each model. Feature importance and pathogenic factors were identified and analyzed using tree-based and gradient boosting models. Three real foodborne disease outbreaks were then used to evaluate the best performing model. Furthermore, the SHapley Additive exPlanation value was used to identify the effect of features. Among all machine learning classification models, the eXtreme Gradient Boosting (XGBoost) model achieved the best performance, with the highest recall rate and F1-score of 0.9699 and 0.9582, respectively. In terms of model validation, the model provides a correct judgment of real outbreaks. In the feature importance analysis with the XGBoost model, the health status of the other people with the same exposure has the highest weight, reaching 0.65. The machine learning model built in this study exhibits high accuracy in recognizing foodborne disease outbreaks, thus reducing the manual burden for medical staff. The model helped us identify the confounding factors of foodborne disease outbreaks. Attention should be paid not only to the health status of those with the same exposure but also to the similarity of the cases in time and space. FAU - Zhang, Peng AU - Zhang P AUID- ORCID: 0000-0001-9938-9965 AD - Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. AD - School of Computer Science and Technology, University of Chinese Academy of Sciences, Beijing, China. FAU - Cui, Wenjuan AU - Cui W AD - Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. FAU - Wang, Hanxue AU - Wang H AD - Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. AD - School of Computer Science and Technology, University of Chinese Academy of Sciences, Beijing, China. FAU - Du, Yi AU - Du Y AD - Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. AD - School of Computer Science and Technology, University of Chinese Academy of Sciences, Beijing, China. FAU - Zhou, Yuanchun AU - Zhou Y AD - Computer Network Information Center, Chinese Academy of Sciences, Beijing, China. AD - School of Computer Science and Technology, University of Chinese Academy of Sciences, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210426 PL - United States TA - Foodborne Pathog Dis JT - Foodborne pathogens and disease JID - 101120121 SB - IM MH - China/epidemiology MH - Disease Outbreaks/*statistics & numerical data MH - Foodborne Diseases/*epidemiology/microbiology MH - Hazard Analysis and Critical Control Points/*methods MH - Humans MH - *Machine Learning MH - Population Surveillance/*methods MH - Risk Assessment/methods PMC - PMC8390778 OTO - NOTNLM OT - foodborne disease OT - foodborne disease outbreaks OT - machine learning COIS- No competing financial interests exist. EDAT- 2021/04/28 06:00 MHDA- 2021/12/18 06:00 PMCR- 2021/08/12 CRDT- 2021/04/27 05:31 PHST- 2021/04/28 06:00 [pubmed] PHST- 2021/12/18 06:00 [medline] PHST- 2021/04/27 05:31 [entrez] PHST- 2021/08/12 00:00 [pmc-release] AID - 10.1089/fpd.2020.2913 [pii] AID - 10.1089/fpd.2020.2913 [doi] PST - ppublish SO - Foodborne Pathog Dis. 2021 Aug;18(8):590-598. doi: 10.1089/fpd.2020.2913. Epub 2021 Apr 26. PMID- 25649543 OWN - NLM STAT- MEDLINE DCOM- 20151207 LR - 20240322 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 16 IP - 1 DP - 2015 Feb 4 TI - A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs dexamethasone injection in rotator cuff syndrome: the TRAumeel in ROtator cuff syndrome (TRARO) study protocol. PG - 8 LID - 10.1186/s12891-015-0471-z [doi] LID - 8 AB - BACKGROUND: Shoulder pain is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus corticosteroid injections and placebo in the treatment of rotator cuff syndrome and bursitis and expand the current evidence base for the conservative treatment of rotator cuff syndrome. METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus dexamethasone 8 mg injection versus placebo (saline solution). Patients will be randomly allocated to Traumeel, dexamethasone or placebo in a 2:2:1 randomization. After 1 week screening, patients will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female patients aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of chronic rotator cuff syndrome and/or bursitis. Patients with calcifications in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 patients will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be paracetamol (acetaminophen), with usage recorded. The primary endpoint is change from baseline in abduction-rotation pain visual analog scale (0-100 mm scale, 0 corresponds to no pain and 100 to extreme pain) at day 22 (Traumeel injections versus dexamethasone injections) for active external rotation. Secondary efficacy parameters include range of motion, disability of arm, shoulder, hand score and patient's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to dexamethasone regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12. FAU - Vanden Bossche, Luc AU - Vanden Bossche L AD - Physical and Rehabilitation Medicine, Sportsmedicine, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. Luc.VandenBossche@UGent.be. FAU - Vanderstraeten, Guy AU - Vanderstraeten G AD - Department of Rehabilitation Sciences and Physical Therapy, Faculty of Medicine and Health Sciences, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. Guy.Vanderstraeten@Ugent.be. LA - eng SI - EudraCT/2012-003393-12 SI - ClinicalTrials.gov/NCT01702233 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20150204 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 RN - 0 (Glucocorticoids) RN - 0 (Minerals) RN - 0 (Plant Extracts) RN - 0 (Traumeel S) RN - 7S5I7G3JQL (Dexamethasone) SB - IM MH - Adult MH - Dexamethasone/*administration & dosage MH - Double-Blind Method MH - Female MH - Glucocorticoids/*administration & dosage MH - Homeopathy MH - Humans MH - Injections, Intralesional MH - Male MH - Medication Adherence MH - Middle Aged MH - Minerals/*administration & dosage MH - Patient Dropouts MH - Plant Extracts/*administration & dosage MH - Range of Motion, Articular MH - Research Design MH - Rotator Cuff/physiopathology MH - *Rotator Cuff Injuries MH - Sample Size MH - Shoulder Pain/*drug therapy MH - Syndrome MH - Treatment Outcome PMC - PMC4320445 EDAT- 2015/02/05 06:00 MHDA- 2015/12/15 06:00 PMCR- 2015/02/04 CRDT- 2015/02/05 06:00 PHST- 2014/04/23 00:00 [received] PHST- 2015/01/15 00:00 [accepted] PHST- 2015/02/05 06:00 [entrez] PHST- 2015/02/05 06:00 [pubmed] PHST- 2015/12/15 06:00 [medline] PHST- 2015/02/04 00:00 [pmc-release] AID - s12891-015-0471-z [pii] AID - 471 [pii] AID - 10.1186/s12891-015-0471-z [doi] PST - epublish SO - BMC Musculoskelet Disord. 2015 Feb 4;16(1):8. doi: 10.1186/s12891-015-0471-z. PMID- 37159970 OWN - NLM STAT- MEDLINE DCOM- 20230529 LR - 20230529 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 188 DP - 2023 Aug TI - Assessing the crash risk of mixed traffic on multilane rural highways using a proactive safety approach. PG - 107099 LID - S0001-4575(23)00146-X [pii] LID - 10.1016/j.aap.2023.107099 [doi] AB - The crash risk assessment of mixed traffic has been understudied due to a lack of pertinent data. In recent years, proactive methods have gained significant attention in transportation safety analysis because of their numerous advantages. In this study, we model and evaluate the effect of speed difference on the sideswipe crash risk of mixed traffic using a novel proactive safety indicator called Anticipated Collision Time (ACT). For analysis, detailed trajectory data were collected using an unmanned aerial vehicle from four-lane and six-lane rural highways. The crash risk was derived from the observed conflict risk and then used to assess the highway system's safety performance under study. Using the Extreme Value Theory (EVT), the conflict risk was mapped to the crash risk. The extreme events were identified using the Block Maxima (BM) approach. Later, the Generalized Extreme Value Distribution (GEV) models were developed for each location by extracting the sideswipe conflicts from the vehicle trajectories. The findings suggest that sideswipe conflicts are more of a safety concern than rear-end conflicts due to the frequent nature of lane changes or passing operations. Also, significant speed difference exists among different vehicle modes present in mixed traffic, and the sideswipe crash risk increases with the increase in the maximum speed difference. The analyses of speed differences also indicate that compared to the four-lane highway, the available safety margin is limited on a six-lane highway due to the higher maximum speed difference. Hence, any driver error may lead to sideswipe crashes. In light of the findings of this study, we strongly suggest the need to provide speed control strategies and restrict the frequent risky lane-changing or passing operations that mainly give rise to sideswipe conflicts on a six-lane highway. Further, this study found that the sideswipe crash risk decreases with the increase in vehicle size on both four-lane and six-lane highways. Hence, we suggest developing separate crash risk models for different vehicle modes in mixed traffic on multilane rural highways. Otherwise, the crash risk mitigation strategies may not be appropriate for mixed traffic conditions. CI - Copyright © 2023 Elsevier Ltd. All rights reserved. FAU - Kar, Pranab AU - Kar P AD - Indian Institute of Technology Guwahati, India. Electronic address: pranabkar69@gmail.com. FAU - Venthuruthiyil, Suvin P AU - Venthuruthiyil SP AD - Indian Institute of Technology Hyderabad, India. Electronic address: pv.suvin@ce.iith.ac.in. FAU - Chunchu, Mallikarjuna AU - Chunchu M AD - Indian Institute of Technology Guwahati, India. Electronic address: c.mallikarjuna@iitg.ac.in. LA - eng PT - Journal Article DEP - 20230507 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Humans MH - *Accidents, Traffic MH - *Automobile Driving MH - Risk Assessment MH - Attention MH - Rural Population MH - Safety OTO - NOTNLM OT - Anticipated collision time OT - Crash risk OT - Extreme value theory OT - Mixed traffic OT - Multilane highways OT - Sideswipe conflict COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/05/09 18:41 MHDA- 2023/05/29 06:41 CRDT- 2023/05/09 18:00 PHST- 2023/02/07 00:00 [received] PHST- 2023/04/10 00:00 [revised] PHST- 2023/05/01 00:00 [accepted] PHST- 2023/05/29 06:41 [medline] PHST- 2023/05/09 18:41 [pubmed] PHST- 2023/05/09 18:00 [entrez] AID - S0001-4575(23)00146-X [pii] AID - 10.1016/j.aap.2023.107099 [doi] PST - ppublish SO - Accid Anal Prev. 2023 Aug;188:107099. doi: 10.1016/j.aap.2023.107099. Epub 2023 May 7. PMID- 34246877 OWN - NLM STAT- MEDLINE DCOM- 20210824 LR - 20210824 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 159 DP - 2021 Sep TI - A novel agent-based framework for evaluating pedestrian safety at unsignalized mid-block crosswalks. PG - 106288 LID - S0001-4575(21)00319-5 [pii] LID - 10.1016/j.aap.2021.106288 [doi] AB - A critical safety problem in road networks is the conflicts on unsignalized crosswalks. Thus, a proactive approach to assess pedestrian safety performance is required. Simulating the microscopic road user behavior in a virtual platform is one of the typical approaches. However, current simulation tools are not flexible enough to properly reproduce various behaviors of pedestrians and drivers considering their interactions with the road environment and other road users. Therefore, the objective of this paper is to propose a novel agent-based framework for evaluating pedestrian safety at unsignalized crosswalks. Unsignalized mid-block crosswalks with refuge islands (UMCR) are considered as an example facility to implement the proposed framework, where relevant behavioral elements such as the reaction time, visual field with obstacles, and minimum safety margin time are addressed. Not only the pedestrian-vehicle interaction is modeled but also the vehicle-vehicle interaction is considered. Empirical validation on a UMCR shows that the proposed framework can reproduce reliable distributions of the post encroachment time compared to the observed distributions within an acceptable error range. The sensitivity analysis reveals that the high reaction time of drivers, small safety margin time, and visual obstacles near crosswalks increase the probability of serious conflicts. The results also show that the framework can reproduce traffic crashes under assumed extreme road conditions. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Zhu, Hong AU - Zhu H AD - Department of Environmental Engineering and Architecture, Graduate School of Environmental Studies, Nagoya University, Nagoya 464-8603, Japan. Electronic address: zhu.hong@a.mbox.nagoya-u.ac.jp. FAU - Almukdad, Abdulkarim AU - Almukdad A AD - Qatar Transportation and Traffic Safety Center, College of Engineering, Qatar University, P.O.Box 2713, Doha, Qatar. Electronic address: karim.almukdad@qu.edu.qa. FAU - Iryo-Asano, Miho AU - Iryo-Asano M AD - Department of Environmental Engineering and Architecture, Graduate School of Environmental Studies, Nagoya University, Nagoya 464-8603, Japan. Electronic address: iryo@nagoya-u.jp. FAU - Alhajyaseen, Wael K M AU - Alhajyaseen WKM AD - Qatar Transportation and Traffic Safety Center, College of Engineering, Qatar University, P.O.Box 2713, Doha, Qatar; Department of Civil & Architectural Engineering, College of Engineering, Qatar University, P.O.Box 2713, Doha, Qatar. Electronic address: wyaseen@qu.edu.qa. FAU - Nakamura, Hideki AU - Nakamura H AD - Department of Environmental Engineering and Architecture, Graduate School of Environmental Studies, Nagoya University, Nagoya 464-8603, Japan. Electronic address: nakamura@genv.nagoya-u.ac.jp. FAU - Zhang, Xin AU - Zhang X AD - Department of Environmental Engineering and Architecture, Graduate School of Environmental Studies, Nagoya University, Nagoya 464-8603, Japan. Electronic address: zhang@genv.nagoya-u.ac.jp. LA - eng PT - Journal Article DEP - 20210708 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/prevention & control MH - Humans MH - *Pedestrians MH - Probability MH - Reaction Time MH - Safety MH - Walking OTO - NOTNLM OT - Agent-based model OT - Pedestrians-vehicles interaction OT - Post encroachment time OT - Reaction time OT - Unsignalized crosswalks OT - Visual obstacle EDAT- 2021/07/12 06:00 MHDA- 2021/08/25 06:00 CRDT- 2021/07/11 20:43 PHST- 2021/03/25 00:00 [received] PHST- 2021/06/11 00:00 [revised] PHST- 2021/06/28 00:00 [accepted] PHST- 2021/07/12 06:00 [pubmed] PHST- 2021/08/25 06:00 [medline] PHST- 2021/07/11 20:43 [entrez] AID - S0001-4575(21)00319-5 [pii] AID - 10.1016/j.aap.2021.106288 [doi] PST - ppublish SO - Accid Anal Prev. 2021 Sep;159:106288. doi: 10.1016/j.aap.2021.106288. Epub 2021 Jul 8. PMID- 17166800 OWN - NLM STAT- MEDLINE DCOM- 20070116 LR - 20220408 IS - 1474-4422 (Print) IS - 1474-4465 (Electronic) IS - 1474-4422 (Linking) VI - 6 IP - 1 DP - 2007 Jan TI - The social and economic impact of epilepsy in Zambia: a cross-sectional study. PG - 39-44 AB - BACKGROUND: Among the 40 million people with epilepsy worldwide, 80% reside in low-income regions where human and technological resources for care are extremely limited. Qualitative and experiential reports indicate that people with epilepsy in Africa are also disadvantaged socially and economically, but few quantitative systematic data are available. We sought to assess the social and economic effect of living with epilepsy in sub-Saharan Africa. METHODS: We did a cross-sectional study of people with epilepsy concurrently matched for age, sex, and site of care to individuals with a non-stigmatised chronic medical condition. Verbally administered questionnaires provided comparison data for demographic characteristics, education, employment status, housing and environment quality, food security, healthcare use, personal safety, and perceived stigma. FINDINGS: People with epilepsy had higher mean perceived stigma scores (1.8 vs 0.4; p<0.0001), poorer employment status (p=0.0001), and less education (7.1 vs 9.4 years; p<0.0001) than did the comparison group. People with epilepsy also had less education than their nearest-age same sex sibling (7.1 vs 9.1 years; p<0.0001), whereas the comparison group did not (9.4 vs 9.6 years; p=0.42). Housing and environmental quality were poorer for people with epilepsy, who had little access to water, were unlikely to have electricity in their home (19%vs 51%; p<0.0001), and who had greater food insecurity than did the control group. During pregnancy, women with epilepsy were more likely to deliver at home rather than in a hospital or clinic (40%vs 15%; p=0.0007). Personal safety for people with epilepsy was also more problematic; rape rates were 20% among women with epilepsy vs 3% in the control group (p=0.004). INTERPRETATION: People with epilepsy in Zambia have substantially poorer social and economic status than do their peers with non-stigmatised chronic medical conditions. Suboptimum housing quality differentially exposes these individuals to the risk of burns and drowning during a seizure. Vulnerability to physical violence is extreme, especially for women with epilepsy. FAU - Birbeck, Gretchen AU - Birbeck G AD - Michigan State University's International Neurologic and Psychiatric Epidemiology Program, East Lansing, MI 48824-1313, USA. gretchen.birbeck@ht.msu.edu FAU - Chomba, Elwyn AU - Chomba E FAU - Atadzhanov, Masharip AU - Atadzhanov M FAU - Mbewe, Edward AU - Mbewe E FAU - Haworth, Alan AU - Haworth A LA - eng GR - K23 NS046086/NS/NINDS NIH HHS/United States GR - NS46086/NS/NINDS NIH HHS/United States GR - NS48060/NS/NINDS NIH HHS/United States GR - R21 NS048060-03/NS/NINDS NIH HHS/United States GR - R21 NS048060/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PL - England TA - Lancet Neurol JT - The Lancet. Neurology JID - 101139309 SB - IM MH - Adult MH - Age of Onset MH - Aged MH - Cross-Sectional Studies MH - Delivery of Health Care/economics/statistics & numerical data MH - Education MH - Employment MH - Environment MH - Epilepsy/*economics/*epidemiology MH - Family MH - Female MH - Food Supply MH - Health Care Surveys MH - Housing MH - Humans MH - Male MH - Marital Status MH - Middle Aged MH - Prejudice MH - Safety MH - Sex Factors MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - Zambia PMC - PMC2938018 MID - NIHMS232240 COIS- Conflicts of interest We have no conflicts of interest. EDAT- 2006/12/15 09:00 MHDA- 2007/01/17 09:00 PMCR- 2010/09/13 CRDT- 2006/12/15 09:00 PHST- 2006/12/15 09:00 [pubmed] PHST- 2007/01/17 09:00 [medline] PHST- 2006/12/15 09:00 [entrez] PHST- 2010/09/13 00:00 [pmc-release] AID - S1474-4422(06)70629-9 [pii] AID - 10.1016/S1474-4422(06)70629-9 [doi] PST - ppublish SO - Lancet Neurol. 2007 Jan;6(1):39-44. doi: 10.1016/S1474-4422(06)70629-9. PMID- 33181509 OWN - NLM STAT- MEDLINE DCOM- 20210916 LR - 20210916 IS - 2504-2106 (Electronic) IS - 2504-2092 (Linking) VI - 28 IP - 3 DP - 2021 TI - Treatment of Dyspepsia, Heartburn, and Related Symptoms with Gastricumeel Compared to Proton Pump Inhibitors: A Prospective Reference-Controlled Observational Study. PG - 234-243 LID - 10.1159/000511285 [doi] AB - BACKGROUND: Dyspepsia and heartburn are extremely common conditions, thus a search for safe and effective treatment alternatives is justified. OBJECTIVES: To demonstrate the noninferiority of Gastricumeel (Ga6) in terms of effectiveness and safety to proton pump inhibitors (PPIs) in the treatment of patients with dyspepsia and/or heartburn. METHODS: Prospective, comparative, observational cohort study. Patients with dyspepsia or heartburn were treated either with Ga6 or with PPIs as monotherapy during approximately 6 weeks. The intensity of eight symptoms was assessed as well as overall condition, treatment compliance and tolerability, and any adverse drug reactions. Adjustment for covariates was done via the calculation of propensity scores in logistic regression. RESULTS: A total of 640 patients (447 Ga6, 193 PPIs) from 48 German general practices participated. More than half the patients had suspected acute gastritis and around 40% of patients had heartburn. Adjusted between-treatment difference scores of changes in the intensity of the eight assessed symptoms were within the bounds for noninferiority of Ga6 compared to PPIs. Effectiveness ratings were comparable; compliance and tolerability were rated better in the Ga6 group. CONCLUSION: It is worth considering Ga6 as a safe and effective treatment option in the management of dyspepsia and heartburn. CI - © 2020 The Author(s) Published by S. Karger AG, Basel. FAU - van Haselen, Robbert AU - van Haselen R AD - International Institute for Integrated Medicine, Kingston, United Kingdom, vanhaselen@intmedi.com. FAU - Cesnulevicius, Konstantin AU - Cesnulevicius K AD - Heel GmbH, Baden-Baden, Germany. LA - eng PT - Journal Article PT - Observational Study TT - Gastricumeel im Vergleich zu Protonenpumpenhemmern in der Behandlung von Dyspepsie, Sodbrennen und damit einhergehenden Symptomen: eine prospektive, referenzkontrollierte Beobachtungsstudie. DEP - 20201112 PL - Switzerland TA - Complement Med Res JT - Complementary medicine research JID - 101698453 RN - 0 (Plant Preparations) RN - 0 (Proton Pump Inhibitors) SB - IM MH - *Dyspepsia/therapy MH - *Gastroesophageal Reflux/therapy MH - Germany MH - *Heartburn/therapy MH - Humans MH - Plant Preparations/*therapeutic use MH - Prospective Studies MH - Proton Pump Inhibitors/therapeutic use OTO - NOTNLM OT - Dyspepsia OT - Gastricumeel OT - Gastritis OT - Gastroesophageal reflux disease OT - Proton pump inhibitors EDAT- 2020/11/13 06:00 MHDA- 2021/09/18 06:00 CRDT- 2020/11/12 20:16 PHST- 2019/09/04 00:00 [received] PHST- 2020/09/01 00:00 [accepted] PHST- 2020/11/13 06:00 [pubmed] PHST- 2021/09/18 06:00 [medline] PHST- 2020/11/12 20:16 [entrez] AID - 000511285 [pii] AID - 10.1159/000511285 [doi] PST - ppublish SO - Complement Med Res. 2021;28(3):234-243. doi: 10.1159/000511285. Epub 2020 Nov 12. PMID- 34408618 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210820 IS - 1658-3612 (Electronic) IS - 1658-3612 (Linking) VI - 16 IP - 4 DP - 2021 Aug TI - Non-gestational choriocarcinoma of the ovary: A case report. PG - 632-636 LID - 10.1016/j.jtumed.2021.01.001 [doi] AB - Non-gestational choriocarcinoma of the ovary is an extremely rare clinical condition. Very few cases of this high-grade malignancy of the ovary are reported in the literature worldwide. Given the rarity of the tumour, this disease is generally overlooked, which leads to delayed diagnosis and management. For the attending clinicians, the non-gestational choriocarcinoma of the ovary poses a diagnostic challenge due to its non-specific clinical presentations. A 16-year-old girl presented with pain in the right iliac fossa and with a positive urine pregnancy test. Despite being sexually inactive, the patient was diagnosed with an ectopic pregnancy and underwent emergency laparoscopic surgery. Six weeks later, the histopathological analysis revealed a diagnosis of non-gestational choriocarcinoma of the ovary. Further evaluations showed that her cancer had already advanced to stage IV. In this case report, the non-specific presentations of the disease, radiological features, current treatments, and possible safety strategies are discussed. CI - © 2021 The Authors. FAU - Yee, Loh S AU - Yee LS AD - Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. FAU - Zakaria, Rosnani AU - Zakaria R AD - Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. FAU - Mohamad, Noraini AU - Mohamad N AD - Department of Medicine, School of Dental Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. FAU - Fong, Ong W AU - Fong OW AD - Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. LA - eng PT - Case Reports PT - Journal Article DEP - 20210129 PL - Saudi Arabia TA - J Taibah Univ Med Sci JT - Journal of Taibah University Medical Sciences JID - 101621911 PMC - PMC8348290 OTO - NOTNLM OT - Adolescent OT - Choriocarcinoma OT - Ectopic pregnancy OT - Non-gestational choriocarcinoma OT - Ovarian neoplasms EDAT- 2021/08/20 06:00 MHDA- 2021/08/20 06:01 PMCR- 2021/01/29 CRDT- 2021/08/19 06:39 PHST- 2020/09/25 00:00 [received] PHST- 2020/12/31 00:00 [revised] PHST- 2021/01/04 00:00 [accepted] PHST- 2021/08/19 06:39 [entrez] PHST- 2021/08/20 06:00 [pubmed] PHST- 2021/08/20 06:01 [medline] PHST- 2021/01/29 00:00 [pmc-release] AID - S1658-3612(21)00024-X [pii] AID - 10.1016/j.jtumed.2021.01.001 [doi] PST - epublish SO - J Taibah Univ Med Sci. 2021 Jan 29;16(4):632-636. doi: 10.1016/j.jtumed.2021.01.001. eCollection 2021 Aug. PMID- 20961165 OWN - NLM STAT- MEDLINE DCOM- 20110513 LR - 20110131 IS - 1941-2703 (Electronic) IS - 1941-2711 (Linking) VI - 24 IP - 1 DP - 2011 Feb TI - Assessing the temperature of thermally generated inhalation aerosols. PG - 11-5 LID - 10.1089/jamp.2010.0835 [doi] AB - BACKGROUND: Condensation aerosols are produced when a drug is vaporized and then cools in the inhalation air. Because energy is applied to vaporize the drug, there is a potential concern that the air temperature might not be well tolerated. A literature review indicates that the proper metric for this is the wet-bulb temperature (T(wb)) of the inhaled air. T(wb) measures the total energy of the air, including moisture content, and reflects the potential impact on safety and tolerability. METHODS: The Staccato® system (Alexza Pharmaceuticals, Mountain View, CA) uses thermal vaporization for aerosol generation and was used in a series of studies to characterize the peak transient value (peak T(wb)) of the air coming out of the device. These studies evaluated peak T(wb) over a range of air flow rates (15-45 L/min), ambient conditions [15-30°C and 15 to 90% relative humidity (RH)] and vaporization temperatures. RESULTS: Under nominal conditions (30 L/min air flow, 25°C and 50% RH), peak T(wb) was 28.8 ± 0.6°C (mean ± standard deviation). Over the range of operating conditions tested, mean values for peak T(wb) ranged from 26.2 to 33.3°C with similarly low variances. When operated under a combination of extreme conditions, peak T(wb) was measured to be 39.9 ± 0.1°C (mean ± standard deviation). CONCLUSIONS: Technical standards indicate that the upper limit on inhaled T(wb) for safety and tolerability is 50°C, and inhalation at that temperature can be sustained for 1 h. Peak values of T(wb) from the Staccato system are well below that threshold, approximately 30°C at nominal conditions and approximately 40°C at a combination of extreme conditions. Moreover, the peak lasts for only a few seconds, well under the time limit of 1 h. These results suggest that aerosols generated with the Staccato system will be safe and well tolerated. FAU - Noymer, Peter D AU - Noymer PD AD - Alexza Pharmaceuticals, Inc., 2091 Stierlin Court, Mountain View, CA 94043, USA. pnoymer@alexza.com FAU - Myers, Dan J AU - Myers DJ FAU - Cassella, James V AU - Cassella JV FAU - Timmons, Ryan AU - Timmons R LA - eng PT - Journal Article DEP - 20101020 PL - United States TA - J Aerosol Med Pulm Drug Deliv JT - Journal of aerosol medicine and pulmonary drug delivery JID - 101475057 RN - 0 (Aerosols) RN - 0 (Pharmaceutical Preparations) MH - Administration, Inhalation MH - Aerosols MH - *Drug Delivery Systems MH - Equipment Design MH - Humans MH - Humidity MH - *Nebulizers and Vaporizers MH - Pharmaceutical Preparations/*administration & dosage MH - Technology, Pharmaceutical MH - Temperature EDAT- 2010/10/22 06:00 MHDA- 2011/05/14 06:00 CRDT- 2010/10/22 06:00 PHST- 2010/10/22 06:00 [entrez] PHST- 2010/10/22 06:00 [pubmed] PHST- 2011/05/14 06:00 [medline] AID - 10.1089/jamp.2010.0835 [doi] PST - ppublish SO - J Aerosol Med Pulm Drug Deliv. 2011 Feb;24(1):11-5. doi: 10.1089/jamp.2010.0835. Epub 2010 Oct 20. PMID- 27802296 OWN - NLM STAT- MEDLINE DCOM- 20170621 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 11 DP - 2016 TI - A Risk Score for Predicting Multiple Sclerosis. PG - e0164992 LID - 10.1371/journal.pone.0164992 [doi] LID - e0164992 AB - OBJECTIVE: Multiple sclerosis (MS) develops as a result of environmental influences on the genetically susceptible. Siblings of people with MS have an increased risk of both MS and demonstrating asymptomatic changes in keeping with MS. We set out to develop an MS risk score integrating both genetic and environmental risk factors. We used this score to identify siblings at extremes of MS risk and attempted to validate the score using brain MRI. METHODS: 78 probands with MS, 121 of their unaffected siblings and 103 healthy controls were studied. Personal history was taken, and serological and genetic analysis using the illumina immunochip was performed. Odds ratios for MS associated with each risk factor were derived from existing literature, and the log values of the odds ratios from each of the risk factors were combined in an additive model to provide an overall score. Scores were initially calculated using log odds ratio from the HLA-DRB1*1501 allele only, secondly using data from all MS-associated SNPs identified in the 2011 GWAS. Subjects with extreme risk scores underwent validation studies. MRI was performed on selected individuals. RESULTS: There was a significant difference in the both risk scores between people with MS, their unaffected siblings and healthy controls (p<0.0005). Unaffected siblings had a risk score intermediate to people with MS and controls (p<0.0005). The best performing risk score generated an AUC of 0.82 (95%CI 0.75-0.88). INTERPRETATIONS: The risk score demonstrates an AUC on the threshold for clinical utility. Our score enables the identification of a high-risk sibling group to inform pre-symptomatic longitudinal studies. FAU - Dobson, Ruth AU - Dobson R AD - Queen Mary University London; Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. FAU - Ramagopalan, Sreeram AU - Ramagopalan S AD - Queen Mary University London; Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. FAU - Topping, Joanne AU - Topping J AD - Queen Mary University London; Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. FAU - Smith, Paul AU - Smith P AD - Royal London Hospital, Barts Health NHS Trust, London, United Kingdom. FAU - Solanky, Bhavana AU - Solanky B AD - NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Institute of Neurology, London, United Kingdom. FAU - Schmierer, Klaus AU - Schmierer K AD - Queen Mary University London; Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. AD - Royal London Hospital, Barts Health NHS Trust, London, United Kingdom. FAU - Chard, Declan AU - Chard D AD - NMR Research Unit, Queen Square Multiple Sclerosis Centre, University College London (UCL) Institute of Neurology, London, United Kingdom. AD - National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London, United Kingdom. FAU - Giovannoni, Gavin AU - Giovannoni G AD - Queen Mary University London; Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom. AD - Royal London Hospital, Barts Health NHS Trust, London, United Kingdom. LA - eng PT - Journal Article DEP - 20161101 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (HLA-DRB1 Chains) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Alleles MH - Female MH - Gene Frequency/genetics MH - Genetic Predisposition to Disease/*genetics MH - Genetic Testing/methods MH - Genotype MH - HLA-DRB1 Chains/genetics MH - Humans MH - Male MH - Middle Aged MH - Multiple Sclerosis/*genetics MH - Odds Ratio MH - Polymorphism, Single Nucleotide/genetics MH - Risk Factors MH - Young Adult PMC - PMC5089761 COIS- RD, SR, JT, and BS have no conflicts of interest to declare. KS is PI of trials sponsored by Novartis & Roche. He is involved in trials sponsored by Biogen, Genzyme, Teva, Merck Inc. and BIAL. Speaking honoraria from, and/or in an advisory role for, Novartis, Sanofi-Aventis, Merck-Serono and Merck Inc. DC has received research support from the MS Society of Great Britain and Northern Ireland, and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. He has received honoraria (paid to his employer) from Ismar Healthcare NV, Swiss MS Society, Excemed (previously Serono Symposia International Foundation), Merck, Bayer and Teva for faculty-led education work; Teva for advisory board work; meeting expenses from Merck, Teva, Novartis, the MS Trust and National MS Society; and has previously held stock in GlaxoSmithKline. He is a member of the MS Society of Great Britain and Northern Ireland's Biomedical Grant Review Panel. He is a member of the Data Safety Monitoring Committee for the PROXIMUS study, which is funded by National Multiple Sclerosis Society and Novartis. Both of these roles are unpaid. GG has received research grant support from Bayer-Schering Healthcare, Biogen-Idec, GW Pharma, Merck Serono, Merz, Novartis, Teva and Sanofi-Aventis. He has received personal compensation for participating on Advisory Boards in relation to clinical trial design, trial steering committees and data and safety monitoring committees from: Bayer-Schering Healthcare, Biogen-Idec, Eisai, Elan, Fiveprime, Genzyme, Genentech, GSK, GW Pharma, Ironwood, Merck-Serono, Novartis, Pfizer, Roche, Sanofi-Aventis, Synthon BV, Teva, UCB Pharma and Vertex Pharmaceuticals. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2016/11/02 06:00 MHDA- 2017/06/22 06:00 PMCR- 2016/11/01 CRDT- 2016/11/02 06:00 PHST- 2016/03/15 00:00 [received] PHST- 2016/10/04 00:00 [accepted] PHST- 2016/11/02 06:00 [pubmed] PHST- 2017/06/22 06:00 [medline] PHST- 2016/11/02 06:00 [entrez] PHST- 2016/11/01 00:00 [pmc-release] AID - PONE-D-16-10662 [pii] AID - 10.1371/journal.pone.0164992 [doi] PST - epublish SO - PLoS One. 2016 Nov 1;11(11):e0164992. doi: 10.1371/journal.pone.0164992. eCollection 2016. PMID- 33274910 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201217 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 12 IP - 50 DP - 2020 Dec 16 TI - Mechanistic Analysis of Microstructural Attributes to Lithium Plating in Fast Charging. PG - 55795-55808 LID - 10.1021/acsami.0c15144 [doi] AB - Metallic lithium deposition on graphite anodes is a critical degradation mode in lithium-ion batteries, which limits safety and fast charge capability. A conclusive strategy to mitigate lithium deposition under fast charging yet remains elusive. In this work, we examine the role of electrode microstructure in mitigating lithium plating behavior under various operating conditions, including fast charging. The multilength scale characteristics of the electrode microstructure lead to a complex interaction of transport and kinetic limitations that significantly governs the cell performance and the occurrence of Li plating. We demonstrate, based on a comprehensive mesoscale analysis, that the performance and degradation can be significantly modulated via systematic design improvements at the hierarchy of length scales. It is found that the improvement in kinetic and transport characteristics achievable at disparate scales can dramatically affect Li plating propensity. FAU - Kabra, Venkatesh AU - Kabra V AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Parmananda, Mukul AU - Parmananda M AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Fear, Conner AU - Fear C AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Usseglio-Viretta, Francois L E AU - Usseglio-Viretta FLE AD - Center for Integrated Mobility Sciences, National Renewable Energy Laboratory, Golden, Colorado 80401, United States. FAU - Colclasure, Andrew AU - Colclasure A AD - Center for Integrated Mobility Sciences, National Renewable Energy Laboratory, Golden, Colorado 80401, United States. FAU - Smith, Kandler AU - Smith K AD - Center for Integrated Mobility Sciences, National Renewable Energy Laboratory, Golden, Colorado 80401, United States. FAU - Mukherjee, Partha P AU - Mukherjee PP AUID- ORCID: 0000-0001-7900-7261 AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. LA - eng PT - Journal Article DEP - 20201204 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - Li plating OT - battery safety OT - electrode microstructure OT - extreme fast charging OT - lithium-ion batteries OT - mesoscale modeling OT - porous composite electrode OT - secondary phase morphology EDAT- 2020/12/05 06:00 MHDA- 2020/12/05 06:01 CRDT- 2020/12/04 12:06 PHST- 2020/12/05 06:00 [pubmed] PHST- 2020/12/05 06:01 [medline] PHST- 2020/12/04 12:06 [entrez] AID - 10.1021/acsami.0c15144 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55795-55808. doi: 10.1021/acsami.0c15144. Epub 2020 Dec 4. PMID- 31141456 OWN - NLM STAT- MEDLINE DCOM- 20200102 LR - 20200102 IS - 1521-057X (Electronic) IS - 0194-7648 (Linking) VI - 39 IP - 1 DP - 2019 Jan-Mar TI - 360 Years of Measles: Limiting Liberty Now for a Healthier Future. PG - 1-13 LID - 10.1080/01947648.2019.1568937 [doi] AB - The United States Supreme Court has upheld state vaccination mandates as a condition of entry to schools by relying on their police power in protecting public health and safety. Despite this broad authority, many state mandates include exemptions that permit parents to refuse vaccination on behalf of their children for nonmedical reasons, like religious, philosophical, or personal beliefs. A spectrum of these laws currently exists, ranging from California's ban of all nonmedical claims to Ohio's extremely permissive grant of exemptions. This article discusses each of these states' mandates and the relationship between relaxed exemption laws and measles outbreaks using statistical analyses. To curb the spread of this vaccine-preventable disease, states should consider the threat to public health paramount to individual liberty infringement by restricting access to nonmedical exemptions. This approach aligns with a century of case law that has rejected vaccination mandate challenges based on fundamental rights, religious freedom, equal protection, and due process. Now states must act within that authority to safeguard against the persistence of this potentially fatal disease. FAU - Fadel, Mark AU - Fadel M LA - eng PT - Journal Article PL - United States TA - J Leg Med JT - The Journal of legal medicine JID - 8000151 RN - 0 (Measles Vaccine) SB - IM MH - California MH - Child MH - Child, Preschool MH - Civil Rights MH - Humans MH - Immunization Programs/*legislation & jurisprudence/trends MH - Mandatory Programs/*legislation & jurisprudence/trends MH - Measles/*prevention & control/transmission MH - Measles Vaccine/*administration & dosage MH - Ohio MH - Parents MH - Public Health/legislation & jurisprudence MH - Religion MH - *Schools MH - State Government MH - Supreme Court Decisions MH - United States MH - Vaccination/*legislation & jurisprudence/trends MH - Vaccination Coverage/trends MH - Vaccination Refusal/*legislation & jurisprudence/trends EDAT- 2019/05/30 06:00 MHDA- 2020/01/03 06:00 CRDT- 2019/05/30 06:00 PHST- 2019/05/30 06:00 [entrez] PHST- 2019/05/30 06:00 [pubmed] PHST- 2020/01/03 06:00 [medline] AID - 10.1080/01947648.2019.1568937 [doi] PST - ppublish SO - J Leg Med. 2019 Jan-Mar;39(1):1-13. doi: 10.1080/01947648.2019.1568937. PMID- 37073976 OWN - NLM STAT- MEDLINE DCOM- 20230526 LR - 20230701 IS - 2165-0969 (Electronic) IS - 2165-0799 (Linking) VI - 71 IP - 6 DP - 2023 Jun TI - Health Status, Health Care Access, and Health Information Sources Among Latino Immigrant Cattle Feedyard Workers in the Midwest. PG - 296-303 LID - 10.1177/21650799231163134 [doi] AB - BACKGROUND: Cattle production in the United States is heavily supported by Latino/a workers. Beyond injury rates, our understanding of the health status of cattle feedyard workers is limited. The purpose of this study was to describe the health status and health care access among Latino immigrant cattle feedyard workers in the Midwest. METHODS: A cross-sectional design using face-to-face structured interviews with Latino immigrant cattle feedyard workers in Kansas and Nebraska was conducted between May 2017 and February 2020. FINDINGS: A total of 243 workers completed interviews; 91% were men. Over half (58%) had health insurance but few (36%) had a regular health care provider. Few chronic health conditions were reported despite most being overweight (53%) or obese (37%). The sample mean of sleep hours/24 hours was 7.1 ± 1.1. Problem drinking was moderate (42%), cigarette smoking was low (14%), and drug use was extremely low (<1%). Receiving health information from work was associated with less problem drinking, less obesity, lower blood pressure, and better sleep. CONCLUSIONS: Although few workers reported having a chronic health condition, most workers had chronic disease risk (i.e., elevated body mass index, problem drinking) and few had a regular health care provider. Receiving health information at work may have protective health effects. APPLICATIONS TO PRACTICE: Occupational health professionals can partner with feedyard employers to expand current health and safety training programs beyond injury prevention to focus on health more broadly and to connect workers with local health care resources. FAU - Rowland, Sheri A AU - Rowland SA AUID- ORCID: 0000-0002-8967-4161 AD - College of Nursing, University of Nebraska Medical Center. FAU - Ramos, Athena K AU - Ramos AK AUID- ORCID: 0000-0002-5194-8243 AD - Department of Health Promotion, College of Public Health, University of Nebraska Medical Center. FAU - Maiya, Sahitya AU - Maiya S AD - Department of Human Development and Family Studies, University of New Hampshire. FAU - Carlo, Gustavo AU - Carlo G AD - School of Education, University of California, Irvine. LA - eng GR - U54 OH010162/OH/NIOSH CDC HHS/United States PT - Journal Article DEP - 20230419 PL - United States TA - Workplace Health Saf JT - Workplace health & safety JID - 101575677 MH - Animals MH - Cattle MH - Humans MH - Alcoholism MH - Chronic Disease MH - Cross-Sectional Studies MH - *Health Services Accessibility MH - *Health Status MH - Hispanic or Latino MH - *Information Sources MH - Obesity MH - Agriculture OTO - NOTNLM OT - Latino/Hispanic OT - agricultural health OT - farmworkers OT - feedlot EDAT- 2023/04/19 12:42 MHDA- 2023/05/26 06:42 CRDT- 2023/04/19 08:13 PHST- 2023/05/26 06:42 [medline] PHST- 2023/04/19 12:42 [pubmed] PHST- 2023/04/19 08:13 [entrez] AID - 10.1177/21650799231163134 [doi] PST - ppublish SO - Workplace Health Saf. 2023 Jun;71(6):296-303. doi: 10.1177/21650799231163134. Epub 2023 Apr 19. PMID- 29057474 OWN - NLM STAT- MEDLINE DCOM- 20180910 LR - 20180910 IS - 1399-3054 (Electronic) IS - 0031-9317 (Linking) VI - 163 IP - 1 DP - 2018 May TI - Intraspecific variation in embolism resistance and stem anatomy across four sunflower (Helianthus annuus L.) accessions. PG - 59-72 LID - 10.1111/ppl.12654 [doi] AB - Drought-induced xylem embolism is a key process closely related to plant mortality during extreme drought events. However, this process has been poorly investigated in crop species to date, despite the observed decline of crop productivity under extreme drought conditions. Interspecific variation in hydraulic traits has frequently been reported, but less is known about intraspecific variation in crops. We assessed the intraspecific variability of embolism resistance in four sunflower (Helianthus annuus L.) accessions grown in well-watered conditions. Vulnerability to embolism was determined by the in situ flow-centrifuge method (cavitron), and possible trade-offs between xylem safety, xylem efficiency and growth were assessed. The relationship between stem anatomy and hydraulic traits was also investigated. Mean P(50) was -3 MPa, but significant variation was observed between accessions, with values ranging between -2.67 and -3.22 MPa. Embolism resistance was negatively related to growth and positively related to xylem-specific hydraulic conductivity. There is, therefore, a trade-off between hydraulic safety and growth but not between hydraulic safety and efficiency. Finally, we found that a few anatomical traits, such as vessel density and the area of the vessel lumen relative to that of the secondary xylem, were related to embolism resistance, whereas stem tissue lignification was not. Further investigations are now required to investigate the link between the observed variability of embolism resistance and yield, to facilitate the identification of breeding strategies to improve yields in an increasingly arid world. CI - © 2017 Scandinavian Plant Physiology Society. FAU - Ahmad, Hafiz B AU - Ahmad HB AD - BIOGECO, INRA, University of Bordeaux, Cestas, France. FAU - Lens, Frederic AU - Lens F AD - Naturalis Biodiversity Center, Leiden University, PO Box 9517, Leiden, the Netherlands. FAU - Capdeville, Gaelle AU - Capdeville G AD - BIOGECO, INRA, University of Bordeaux, Cestas, France. FAU - Burlett, Régis AU - Burlett R AD - BIOGECO, INRA, University of Bordeaux, Cestas, France. FAU - Lamarque, Laurent J AU - Lamarque LJ AD - BIOGECO, INRA, University of Bordeaux, Cestas, France. FAU - Delzon, Sylvain AU - Delzon S AD - BIOGECO, INRA, University of Bordeaux, Cestas, France. LA - eng PT - Journal Article DEP - 20171205 PL - Denmark TA - Physiol Plant JT - Physiologia plantarum JID - 1256322 SB - IM MH - Droughts MH - Helianthus/anatomy & histology/*physiology MH - Plant Stems/anatomy & histology/physiology MH - Species Specificity MH - Xylem/anatomy & histology/physiology EDAT- 2017/10/24 06:00 MHDA- 2018/09/11 06:00 CRDT- 2017/10/24 06:00 PHST- 2017/07/10 00:00 [received] PHST- 2017/10/04 00:00 [revised] PHST- 2017/10/17 00:00 [accepted] PHST- 2017/10/24 06:00 [pubmed] PHST- 2018/09/11 06:00 [medline] PHST- 2017/10/24 06:00 [entrez] AID - 10.1111/ppl.12654 [doi] PST - ppublish SO - Physiol Plant. 2018 May;163(1):59-72. doi: 10.1111/ppl.12654. Epub 2017 Dec 5. PMID- 27055967 OWN - NLM STAT- MEDLINE DCOM- 20161214 LR - 20191008 IS - 1933-2874 (Print) IS - 1876-4789 (Linking) VI - 10 IP - 2 DP - 2016 Mar-Apr TI - Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement. PG - 356-67 LID - S1933-2874(15)30130-6 [pii] LID - 10.1016/j.jacl.2015.12.007 [doi] AB - BACKGROUND: Humans with familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) have extremely low or undetectable high-density lipoprotein cholesterol (HDL-C) levels and by early adulthood develop many manifestations of the disorder, including corneal opacities, anemia, and renal disease. OBJECTIVE: To determine if infusions of recombinant human LCAT (rhLCAT) could reverse the anemia, halt progression of renal disease, and normalize HDL in FLD. METHODS: rhLCAT (ACP-501) was infused intravenously over 1 hour on 3 occasions in a dose optimization phase (0.3, 3.0, and 9.0 mg/kg), then 3.0 or 9.0 mg/kg every 1 to 2 weeks for 7 months in a maintenance phase. Plasma lipoproteins, lipids, LCAT levels, and several measures of renal function and other clinical labs were monitored. RESULTS: LCAT concentration peaked at the end of each infusion and decreased to near baseline over 7 days. Renal function generally stabilized or improved and the anemia improved. After infusion, HDL-C rapidly increased, peaking near normal in 8 to 12 hours; analysis of HDL particles by various methods all revealed rapid sequential disappearance of preβ-HDL and small α-4 HDL and appearance of normal α-HDL. Low-density lipoprotein cholesterol increased more slowly than HDL-C. Of note, triglyceride routinely decreased after meals after infusion, in contrast to the usual postprandial increase in the absence of rhLCAT infusion. CONCLUSIONS: rhLCAT infusions were well tolerated in this first-in-human study in FLD; the anemia improved, as did most parameters related to renal function in spite of advanced disease. Plasma lipids transiently normalized, and there was rapid sequential conversion of small preβ-HDL particles to mature spherical α-HDL particles. CI - Published by Elsevier Inc. FAU - Shamburek, Robert D AU - Shamburek RD AD - Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA. Electronic address: bobs@mail.nih.gov. FAU - Bakker-Arkema, Rebecca AU - Bakker-Arkema R AD - AlphaCore Pharma, Ann Arbor, MI, USA. FAU - Auerbach, Bruce J AU - Auerbach BJ AD - AlphaCore Pharma, Ann Arbor, MI, USA. FAU - Krause, Brian R AU - Krause BR AD - AlphaCore Pharma, Ann Arbor, MI, USA. FAU - Homan, Reynold AU - Homan R AD - AlphaCore Pharma, Ann Arbor, MI, USA. FAU - Amar, Marcelo J AU - Amar MJ AD - Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA. FAU - Freeman, Lita A AU - Freeman LA AD - Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA. FAU - Remaley, Alan T AU - Remaley AT AD - Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA. LA - eng GR - Z01 HL002064-06/Intramural NIH HHS/United States GR - Z01 HL002064-07/Intramural NIH HHS/United States GR - Z99 HL999999/Intramural NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151223 PL - United States TA - J Clin Lipidol JT - Journal of clinical lipidology JID - 101300157 RN - 0 (Cholesterol, HDL) RN - 0 (Recombinant Proteins) RN - EC 2.3.1.43 (Phosphatidylcholine-Sterol O-Acyltransferase) SB - IM MH - Anemia/complications MH - Cholesterol, HDL/blood MH - Disease Progression MH - Hematologic Tests MH - Humans MH - Kidney/drug effects MH - Lecithin Cholesterol Acyltransferase Deficiency/blood/complications/*drug therapy/enzymology MH - Male MH - Middle Aged MH - Phosphatidylcholine-Sterol O-Acyltransferase/adverse effects/pharmacokinetics/pharmacology/*therapeutic use MH - Recombinant Proteins/adverse effects/pharmacokinetics/pharmacology/therapeutic use MH - Safety PMC - PMC4826469 MID - NIHMS747845 OTO - NOTNLM OT - Cholesterol OT - HDL OT - LCAT OT - Lecithin cholesterol acyltransferase OT - Lecithin cholesterol acyltransferase deficiency OT - Lipoprotein-X OT - Recombinant enzyme replacement OT - Renal disease OT - Triglyceride EDAT- 2016/04/09 06:00 MHDA- 2016/12/15 06:00 PMCR- 2017/03/01 CRDT- 2016/04/09 06:00 PHST- 2015/12/12 00:00 [received] PHST- 2015/12/15 00:00 [accepted] PHST- 2017/03/01 00:00 [pmc-release] PHST- 2016/04/09 06:00 [entrez] PHST- 2016/04/09 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - S1933-2874(15)30130-6 [pii] AID - 10.1016/j.jacl.2015.12.007 [doi] PST - ppublish SO - J Clin Lipidol. 2016 Mar-Apr;10(2):356-67. doi: 10.1016/j.jacl.2015.12.007. Epub 2015 Dec 23. PMID- 37133314 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230518 LR - 20240504 IS - 1944-8252 (Electronic) IS - 1944-8244 (Print) IS - 1944-8244 (Linking) VI - 15 IP - 19 DP - 2023 May 17 TI - Direct Observation of the Anisotropic Transport Behavior of Li(+) in Graphite Anodes and Thermal Runaway Induced by the Interlayer Polarization. PG - 23623-23630 LID - 10.1021/acsami.3c02214 [doi] AB - Graphite is one of the major anode materials for commercial lithium-ion batteries. Li(+) transport in a single graphite granule along intra and interlayer modes is a crucial factor for the battery performance. However, direct evidence and visualized details of the Li(+) transports are hardly provided. Here, we report the direct observation of the anisotropic transport behavior of Li(+) and investigate the electro-chemo-structure evolution during the lithiation of graphite through both the intra and interlayer pathways via in situ transmission electron microscopy. The in situ experiments of nano batteries give two extreme conditions, in which thermal runaway induced by polarization only occurs along the interlayer, not along the intralayer. The high diffusion energy barrier induced large polarization when the interlayer Li(+) transport became dominant. The energy of the polarization electric field would be instantaneously released like a short electric pulse, which generated a substantial amount of joule heat and created an extremely high temperature, causing the melting of the tungsten tip. We provide another possible fundamental mechanism of thermal failure in graphite-based Li-ion batteries and hope this insightful work would help the safety management of graphite-based lithium-ion batteries. FAU - Bai, Zhichuan AU - Bai Z AD - School of Materials Science and Engineering, Sichuan University of Science and Engineering, Zigong, Sichuan 643000, P. R. China. AD - Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100094, P. R. China. FAU - Gao, Xiang AU - Gao X AD - Chongqing Talent New Energy Co., Ltd., Chongqing 401133, P. R. China. FAU - Liu, Zheng AU - Liu Z AD - School of Applied Physics and Materials, Jiangmen Advanced Battery Material Engineering and Technology Research Center, Wuyi University, Jiangmen, Guangdong 529020, P. R. China. FAU - Chao, Dongliang AU - Chao D AUID- ORCID: 0000-0001-7793-0044 AD - Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, and School of Chemistry and Materials, Fudan University, Shanghai 200433, P. R. China. FAU - Wang, Yingying AU - Wang Y AD - Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100094, P. R. China. FAU - Yin, Jie AU - Yin J AD - School of Automation and Information Engineering, Sichuan University of Science and Engineering, Zigong, Sichuan 643000, P. R. China. FAU - Jiang, Cairong AU - Jiang C AUID- ORCID: 0000-0001-8499-4062 AD - School of Materials Science and Engineering, Sichuan University of Science and Engineering, Zigong, Sichuan 643000, P. R. China. FAU - Yang, Wenge AU - Yang W AUID- ORCID: 0000-0001-8436-8731 AD - Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100094, P. R. China. FAU - Ma, Jianjun AU - Ma J AUID- ORCID: 0000-0002-0016-6313 AD - School of Materials Science and Engineering, Sichuan University of Science and Engineering, Zigong, Sichuan 643000, P. R. China. FAU - Chen, Yongjin AU - Chen Y AUID- ORCID: 0000-0003-2540-6376 AD - Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100094, P. R. China. AD - Chongqing Talent New Energy Co., Ltd., Chongqing 401133, P. R. China. LA - eng PT - Journal Article DEP - 20230503 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM PMC - PMC10198158 OTO - NOTNLM OT - graphite OT - lithium-ion batteries OT - polarization OT - thermal runaway OT - transmission electron microscopy COIS- The authors declare no competing financial interest. EDAT- 2023/05/03 12:42 MHDA- 2023/05/03 12:43 PMCR- 2024/05/03 CRDT- 2023/05/03 09:23 PHST- 2023/05/03 12:43 [medline] PHST- 2023/05/03 12:42 [pubmed] PHST- 2023/05/03 09:23 [entrez] PHST- 2024/05/03 00:00 [pmc-release] AID - 10.1021/acsami.3c02214 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2023 May 17;15(19):23623-23630. doi: 10.1021/acsami.3c02214. Epub 2023 May 3. PMID- 21970036 OWN - NLM STAT- MEDLINE DCOM- 20111107 LR - 20111005 IS - 0233-528X (Print) IS - 0233-528X (Linking) VI - 45 IP - 4 DP - 2011 Jul-Aug TI - [The cascade scheme as a methodical platform for analysis of health risks in space flight and partially and fully analog conditions]. PG - 3-10 AB - Space anthropoecology, a subsection of human ecology, studies various aspects of physiological, psychological, social and professional adaptation to the extreme environment of space flight and human life and work in partially- and fully analogous conditions on Earth. Both SF and simulated extreme conditions are known for high human safety standards and a substantial analytic base that secures on-line analysis of torrent of information. Management evaluation and response to germing undesired developments aimed to curb their impact on the functioning of the crew-vehicle-environment system and human health involve the complete wealth of knowledge about risks to human health and performance. Spacecrew safety issues are tackled by experts of many specialties which emphasizes the importance of integral methodical approaches to risk estimation and mitigation, setting up barriers to adverse trends in human physiology and psychology in challenging conditions, and minimization of delayed effects on professional longevity and disorders in behavioral reactions. FAU - Ushakov, I B AU - Ushakov IB FAU - Poliakov, A V AU - Poliakov AV FAU - Usov, V M AU - Usov VM LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Aviakosm Ekolog Med JT - Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine JID - 9305904 SB - IM MH - *Adaptation, Physiological MH - Aerospace Medicine MH - *Astronauts MH - *Ecological Systems, Closed MH - Extraterrestrial Environment MH - Humans MH - Risk Assessment MH - *Safety MH - *Space Flight MH - Weightlessness/*adverse effects EDAT- 2011/10/06 06:00 MHDA- 2011/11/08 06:00 CRDT- 2011/10/06 06:00 PHST- 2011/10/06 06:00 [entrez] PHST- 2011/10/06 06:00 [pubmed] PHST- 2011/11/08 06:00 [medline] PST - ppublish SO - Aviakosm Ekolog Med. 2011 Jul-Aug;45(4):3-10. PMID- 20204091 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20120827 LR - 20200929 IS - 1863-5245 (Electronic) IS - 1863-5245 (Linking) VI - 3 IP - 3 DP - 2008 Sep 3 TI - The limits of sterility assurance. PG - Doc19 LID - Doc19 AB - Sterility means the absence of all viable microorganisms including viruses. At present, a sterility assurance level (SAL) of 10(-6) is generally accepted for pharmacopoeial sterilization procedures, i.e., a probability of not more than one viable microorganism in an amount of one million sterilised items of the final product. By extrapolating the reduction rates following extreme artificial initial contamination, a theoretical overall performance of the procedure of at least 12 lg increments (overkill conditions) is demanded to verify an SAL of 10(-6). By comparison, other recommendations for thermal sterilization procedures demand only evidence that the difference between the initial contamination and the number of test organisms at the end of the process amount to more than six orders of magnitude. However, a practical proof of the required level of sterility assurance of 10(-6) is not possible. Moreover, the attainability of this condition is fundamentally dubious, at least in non-thermal procedures. Thus, the question is discussed whether the undifferentiated adherence to the concept of sterility assurance on the basis of a single SAL of 10(-6) corresponds with the safety requirements in terms of patient or user safety, costs and energy efficiency. Therefore, in terms of practical considerations, a concept of tiered SALs is recommended, analogous to the comparable and well-established categorization into "High-level disinfection", "Intermediate-level disinfection" and "Low-level disinfection". The determination of such tiered SALs is geared both to the intended application of the sterilized goods, as well as to the characteristics of the products and the corresponding treatment options.In the case of aseptic preparation, filling and production procedures, a mean contamination probability of 10(-3) is assumed. In automated processes, lower contamination rates can be realized. In the case of the production of re-usable medical devices, a reduction of at least 2 lg increments can be achieved through prior cleaning in validated cleaning and disinfecting devices. By chemical disinfection, a further reduction of >/=5 lg increments is achieved. In the case of sterilized surgical instruments, an additional concern is that they lay opened in contaminated air for the duration of the operation, at least in conventionally ventilated operating theaters. Finally, the amount of pathogens necessary to cause an infection must be considered. By logical consideration of all aspects, it seems possible to partially reduce sterility assurance levels without any loss of safety. Proceeding from this, we would like to make the following suggestions for tiered SAL values, adjusted according to the respective sterilization task:SAL 10(-6) for heat-resistant pharmaceutical preparations (parenterals), suggested term: "Pharmaceutical sterilization",SAL 10(-4) for heat-resistant medical devices, suggested term: "High-level sterilization",SAL 10(-3) for heat-sensitive re-usable medical devices, under the precondition of a validated cleaning efficacy of >4 lg increments, suggested term: "Low-level sterilization". FAU - von Woedtke, Thomas AU - von Woedtke T AD - INP Greifswald e.V. (Leibniz Institute for Plasma Science and Technology), Greifswald, Germany. FAU - Kramer, Axel AU - Kramer A LA - eng PT - Journal Article DEP - 20080903 PL - Germany TA - GMS Krankenhhyg Interdiszip JT - GMS Krankenhaushygiene interdisziplinar JID - 101313359 PMC - PMC2831250 OTO - NOTNLM OT - draft of tiered SAL values OT - sterility OT - sterility assurance level (SAL) EDAT- 2008/01/01 00:00 MHDA- 2008/01/01 00:01 PMCR- 2008/09/03 CRDT- 2010/03/06 06:00 PHST- 2010/03/06 06:00 [entrez] PHST- 2008/01/01 00:00 [pubmed] PHST- 2008/01/01 00:01 [medline] PHST- 2008/09/03 00:00 [pmc-release] AID - dgkh000117 [pii] PST - epublish SO - GMS Krankenhhyg Interdiszip. 2008 Sep 3;3(3):Doc19. PMID- 28314926 OWN - NLM STAT- MEDLINE DCOM- 20180906 LR - 20181113 IS - 1432-1254 (Electronic) IS - 0020-7128 (Linking) VI - 61 IP - 8 DP - 2017 Aug TI - American football and fatal exertional heat stroke: a case study of Korey Stringer. PG - 1471-1480 LID - 10.1007/s00484-017-1324-2 [doi] AB - On August 1, 2001, Korey Stringer, a Pro Bowl offensive tackle for the Minnesota Vikings, became the first and to date the only professional American football player to die from exertional heat stroke (EHS). The death helped raise awareness of the dangers of exertional heat illnesses in athletes and prompted the development of heat safety policies at the professional, collegiate, and interscholastic levels. Despite the public awareness of this death, no published study has examined in detail the circumstances surrounding Stringer's fatal EHS. Using the well-documented details of the case, our study shows that Stringer's fatal EHS was the result of a combination of physiological limitations, organizational and treatment failings, and extreme environmental conditions. The COMfort FormulA (COMFA) energy budget model was used to assess the relative importance of several extrinsic factors on Stringer's EHS, including weather conditions, clothing insulation, and activity levels. We found that Stringer's high-intensity training in relation to the oppressive environmental conditions was the most prominent factor in producing dangerous, uncompensable heat stress conditions and that the full football uniform played a smaller role in influencing Stringer's energy budget. The extreme energy budget levels that led to the fatal EHS would have been avoided according to our modeling through a combination of reduced intensity and lower clothing insulation. Finally, a long delay in providing medical treatment made the EHS fatal. These results highlight the importance of modern heat safety guidelines that provide controls on extrinsic factors, such as the adjustment of duration and intensity of training along with protective equipment modifications based on environmental conditions and the presence of an emergency action plan focused on rapid recognition and immediate on-site aggressive cooling of EHS cases. FAU - Grundstein, Andrew AU - Grundstein A AD - Department of Geography, University of Georgia, Athens, GA, 30602, USA. andrewg@uga.edu. FAU - Knox, John A AU - Knox JA AD - Department of Geography, University of Georgia, Athens, GA, 30602, USA. FAU - Vanos, Jennifer AU - Vanos J AD - Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, 92093, USA. AD - School of Medicine, University of California at San Diego, La Jolla, CA, 92093, USA. FAU - Cooper, Earl R AU - Cooper ER AD - Department of Kinesiology, University of Georgia, Athens, GA, 30602, USA. FAU - Casa, Douglas J AU - Casa DJ AD - Department of Kinesiology, Korey Stringer Institute, University of Connecticut, Storrs, CT, 06269, USA. LA - eng PT - Case Reports PT - Journal Article DEP - 20170317 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - Football MH - Heat Stroke/*mortality MH - Humans MH - Male MH - *Models, Theoretical MH - Weather OTO - NOTNLM OT - Athletics OT - Energy budget modeling OT - Heat illness OT - Safety policy OT - Wet bulb globe temperature EDAT- 2017/03/21 06:00 MHDA- 2018/09/07 06:00 CRDT- 2017/03/19 06:00 PHST- 2016/09/06 00:00 [received] PHST- 2017/02/13 00:00 [accepted] PHST- 2017/02/09 00:00 [revised] PHST- 2017/03/21 06:00 [pubmed] PHST- 2018/09/07 06:00 [medline] PHST- 2017/03/19 06:00 [entrez] AID - 10.1007/s00484-017-1324-2 [pii] AID - 10.1007/s00484-017-1324-2 [doi] PST - ppublish SO - Int J Biometeorol. 2017 Aug;61(8):1471-1480. doi: 10.1007/s00484-017-1324-2. Epub 2017 Mar 17. PMID- 38668084 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240429 IS - 2226-4787 (Electronic) IS - 2226-4787 (Linking) VI - 12 IP - 2 DP - 2024 Mar 28 TI - A Comparison of Currently Approved Small Interfering RNA (siRNA) Medications to Alternative Treatments by Costs, Indications, and Medicaid Coverage. LID - 10.3390/pharmacy12020058 [doi] LID - 58 AB - Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed towards hepatic molecular targets. Because they are not conventional drug formulae, their ultimate clinical success will require overcoming multiple barriers beyond their pharmacology. The minimal patient numbers leave fewer patients to bear the costs of R&D and manufacture; therefore, the cost of these drugs, questionable third-party reimbursement, and competition from other drug classes for the same low number of patients are impediments to patient access. The parenteral route of administration, as well as emerging safety restrictions, are also drawbacks to siRNA. With this review, we document currently approved siRNA drugs by condition, approval date, administration route and frequencies. We have estimated the available patient populations for siran therapies using the U.S. Medicaid and Medicare populations and sought to identify the frequency with which large Medicaid formularies list siRNA drugs. Current comparative costs between the siRNA drugs and alternatives have been presented, and the review summarizes current adverse events as reported to the FDA's Adverse Event Reporting System. Our review and data indicate that sirans are extremely expensive and seldom recognized in posted Medicaid formularies. However, alternative treatments for these conditions are no less costly, usually do not have significantly different adverse events, and are often less convenient for the patient. FAU - Sehgal, Inder AU - Sehgal I AUID- ORCID: 0000-0002-5260-0791 AD - College of Medicine, Rocky Vista University, Ivins, UT 84738, USA. FAU - Eells, Kevin AU - Eells K AD - College of Medicine, Rocky Vista University, Parker, CO 80112, USA. FAU - Hudson, Imani AU - Hudson I AD - College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307, USA. LA - eng PT - Journal Article PT - Review DEP - 20240328 PL - Switzerland TA - Pharmacy (Basel) JT - Pharmacy (Basel, Switzerland) JID - 101678532 PMC - PMC11054365 OTO - NOTNLM OT - Medicaid OT - givosiran OT - inclisiran OT - lumasiran OT - patisiran OT - siRNA OT - vutrisiran COIS- The authors declare no conflicts of interest. EDAT- 2024/04/26 13:25 MHDA- 2024/04/26 13:26 PMCR- 2024/03/28 CRDT- 2024/04/26 09:33 PHST- 2024/02/01 00:00 [received] PHST- 2024/03/21 00:00 [revised] PHST- 2024/03/25 00:00 [accepted] PHST- 2024/04/26 13:26 [medline] PHST- 2024/04/26 13:25 [pubmed] PHST- 2024/04/26 09:33 [entrez] PHST- 2024/03/28 00:00 [pmc-release] AID - pharmacy12020058 [pii] AID - pharmacy-12-00058 [pii] AID - 10.3390/pharmacy12020058 [doi] PST - epublish SO - Pharmacy (Basel). 2024 Mar 28;12(2):58. doi: 10.3390/pharmacy12020058. PMID- 26479232 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20151020 LR - 20201001 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 5 IP - 2 DP - 2015 Apr 10 TI - Characteristics of Trailer Thermal Environment during Commercial Swine Transport Managed under U.S. Industry Guidelines. PG - 226-44 LID - 10.3390/ani5020226 [doi] AB - Transport is a critical factor in modern pork production and can seriously affect swine welfare. While previous research has explored thermal conditions during transport, the impact of extreme weather conditions on the trailer thermal environment under industry practices has not been well documented; and the critical factors impacting microclimate are not well understood. To assess the trailer microclimate during transport events, an instrumentation system was designed and installed at the central ceiling level, pig level and floor-level in each of six zones inside a commercial swine trailer. Transport environmental data from 34 monitoring trips (approximately 1-4 h in duration each) were collected from May, 2012, to February, 2013, with trailer management corresponding to the National Pork Board Transport Quality Assurance (TQA) guidelines in 31 of these trips. According to the TQA guidelines, for outdoor temperature ranging from 5 °C (40 °F) to 27 °C (80 °F), acceptable thermal conditions were observed based on the criteria that no more than 10% of the trip duration was above 35 °C (95 °F) or below 0 °C (32 °F). Recommended bedding, boarding and water application were sufficient in this range. Measurements support relaxing boarding guidelines for moderate outdoor conditions, as this did not result in less desirable conditions. Pigs experienced extended undesirable thermal conditions for outdoor temperatures above 27 °C (80 °F) or below 5 °C (40 °F), meriting a recommendation for further assessment of bedding, boarding and water application guidelines for extreme outdoor temperatures. An Emergency Livestock Weather Safety Index (LWSI) condition was observed inside the trailer when outdoor temperature exceeded 10 °C (50 °F); although the validity of LWSI to indicate heat stress for pigs during transport is not well established. Extreme pig surface temperatures in the rear and middle zones of the trailer were more frequently experienced than in the front zones, and the few observations of pigs dead or down upon arrival were noted in these zones. Observations indicate that arranging boarding placement may alter the ventilation patterns inside the trailer. FAU - Xiong, Yijie AU - Xiong Y AD - Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 W. Pennsylvania Ave, Urbana, IL 61801, USA. yxiong5@illinois.edu. FAU - Green, Angela AU - Green A AD - Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 W. Pennsylvania Ave, Urbana, IL 61801, USA. angelag@illinois.edu. FAU - Gates, Richard S AU - Gates RS AD - Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, 1304 W. Pennsylvania Ave, Urbana, IL 61801, USA. rsgates@illinois.edu. LA - eng PT - Journal Article DEP - 20150410 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC4494411 OTO - NOTNLM OT - cold stress OT - heat stress OT - husbandry OT - management OT - pigs OT - welfare EDAT- 2015/10/21 06:00 MHDA- 2015/10/21 06:01 PMCR- 2015/04/10 CRDT- 2015/10/20 06:00 PHST- 2015/02/03 00:00 [received] PHST- 2015/02/28 00:00 [revised] PHST- 2015/04/03 00:00 [accepted] PHST- 2015/10/20 06:00 [entrez] PHST- 2015/10/21 06:00 [pubmed] PHST- 2015/10/21 06:01 [medline] PHST- 2015/04/10 00:00 [pmc-release] AID - ani5020226 [pii] AID - animals-05-00226 [pii] AID - 10.3390/ani5020226 [doi] PST - epublish SO - Animals (Basel). 2015 Apr 10;5(2):226-44. doi: 10.3390/ani5020226. PMID- 31680606 OWN - NLM STAT- MEDLINE DCOM- 20200929 LR - 20220413 IS - 1724-6040 (Electronic) IS - 0391-3988 (Linking) VI - 43 IP - 4 DP - 2020 Apr TI - Study on in vitro performance verification protocol for left ventricular assist device. PG - 242-251 LID - 10.1177/0391398819882701 [doi] AB - OBJECTIVE: In vitro performance verification of ventricular assist devices using a mock circulatory loop is a prominent step to guarantee the system responses and the device performance and safety before the in vivo tests and ultimately clinical trials. METHODS: In this article, we performed a comprehensive literature research to establish a verification matrix consisting of 12 test cases, defined by a set of physiological parameters which are commonly used to characterize a physiological condition. The clinical hemodynamic indicators for defining successful mechanical support were used as the acceptance criteria. A mock circulatory loop was customized to simulate the test cases, and a full verification protocol was described in details. An example left ventricular assist device was incorporated in the loop to accomplish a standard ventricular assist device performance verification. RESULT: The test cases based on clinical data with sufficient safety margin represent our understanding in defining the extremes of operation. The mock circulatory loop was capable of generating the test conditions in the verification matrix and reproducing the Frank-Starling law of the native heart. The effect of the left ventricular assist device assistance (characterized by the total systemic flow, mean aortic pressure, and left atrial pressure) was well verified by the proposed protocol and acceptance criteria. CONCLUSION: To date, all left ventricular assist devices made in China have been evaluated according this protocol and some of them have entered the clinical trial stage. We are closely observing the clinical data in order to further improve the performance of the platform and encourage more advances in mechanical circulatory assist devices. FAU - Li, Shu AU - Li S AUID- ORCID: 0000-0003-1352-2572 AD - Institute for Medical Device Control, National Institutes for Food and Drug Control, Beijing, China. FAU - Hsu, Po-Lin AU - Hsu PL AD - Artificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, China. FAU - Hao, Ye AU - Hao Y AD - Institute for Medical Device Control, National Institutes for Food and Drug Control, Beijing, China. FAU - Ren, Haiping AU - Ren H AD - Institute for Medical Device Control, National Institutes for Food and Drug Control, Beijing, China. LA - eng PT - Journal Article DEP - 20191104 PL - United States TA - Int J Artif Organs JT - The International journal of artificial organs JID - 7802649 SB - IM MH - Arterial Pressure MH - Cardiovascular System/*physiopathology MH - China MH - *Heart-Assist Devices MH - Hemodynamics MH - Humans MH - Models, Cardiovascular OTO - NOTNLM OT - Mock circulation loop OT - frank-startling law OT - hemodynamics OT - left ventricular assist device OT - verification protocol EDAT- 2019/11/05 06:00 MHDA- 2020/09/30 06:00 CRDT- 2019/11/05 06:00 PHST- 2019/11/05 06:00 [pubmed] PHST- 2020/09/30 06:00 [medline] PHST- 2019/11/05 06:00 [entrez] AID - 10.1177/0391398819882701 [doi] PST - ppublish SO - Int J Artif Organs. 2020 Apr;43(4):242-251. doi: 10.1177/0391398819882701. Epub 2019 Nov 4. PMID- 27573313 OWN - NLM STAT- MEDLINE DCOM- 20171121 LR - 20181202 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 94 DP - 2016 Oct TI - Mobile applications to enhance self-management of gout. PG - 67-74 LID - S1386-5056(16)30150-2 [pii] LID - 10.1016/j.ijmedinf.2016.06.021 [doi] AB - BACKGROUND: Gout is an arthritic condition that is characterised by extremely painful, debilitating acute attacks and eventual joint and organ damage if not controlled. Despite the availability of very effective therapies that, if adhered to, will prevent acute attacks and long-term damage, the disorder is increasingly prevalent. There is an urgent need to improve self-management of gout. OBJECTIVES: Mobile health (mHealth) applications ('apps'), designed to facilitate management of chronic conditions, present novel opportunities for supporting patient self-management of gout. The aim of this review was to assess features of available gout management apps designed to assist consumers in managing their gout and their consistency with guidelines for gout management. METHODS: English-language, smart-device apps designed to assist self-management of gout were identified using search term "gout" and downloaded from Apple and Google Play app stores. To be included in the review, apps had to allow users to monitor their gout disease (e.g. serum uric acid (sUA) tracking, record acute attacks) and/or educate patients about gout. Investigators derived patient-focused recommendations for gout management from contemporary guidelines. Features of reviewed apps were independently assessed by two reviewers for their facilitation of these recommendations. RESULTS: The search identified 57 apps possibly relevant to gout management, of which six met the inclusion criteria. One app incorporated all recommendations for patient-focused gout management from guidelines including monitoring sUA, recording attacks and lifestyle advice. However, the majority of these elements were not functional within the app, and instead required users to manually complete printouts. CONCLUSIONS: Currently, only one app exists that includes all recommendations to facilitate patient self-management of gout, however some features can only be actioned manually. Given the lack of progress in achieving better patient outcomes and the promise of mHealth interventions to deliver significant gains, new or updated gout management apps are required to promote successful self-management of this chronic disease. CI - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. FAU - Nguyen, Amy D AU - Nguyen AD AD - Department of Clinical Pharmacology & Toxicology, St. Vincent's Hospital, Sydney, Australia; St. Vincent's Clinical School, St. Vincent's Hospital, University of New South Wales, Sydney, Australia. FAU - Baysari, Melissa T AU - Baysari MT AD - Department of Clinical Pharmacology & Toxicology, St. Vincent's Hospital, Sydney, Australia; Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia. FAU - Kannangara, Diluk R W AU - Kannangara DR AD - Department of Clinical Pharmacology & Toxicology, St. Vincent's Hospital, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia. FAU - Tariq, Amina AU - Tariq A AD - School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia. FAU - Lau, Annie Y S AU - Lau AY AD - Centre for Health Informatics, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia. FAU - Westbrook, Johanna I AU - Westbrook JI AD - Centre for Health Systems and Safety Research, Australian Institute of Health Innovation, Macquarie University, Sydney, Australia. FAU - Day, Richard O AU - Day RO AD - Department of Clinical Pharmacology & Toxicology, St. Vincent's Hospital, Sydney, Australia; St. Vincent's Clinical School, St. Vincent's Hospital, University of New South Wales, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia. Electronic address: r.day@unsw.edu.au. LA - eng PT - Journal Article DEP - 20160630 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Chronic Disease MH - Disease Management MH - Gout/*therapy MH - Humans MH - Mobile Applications/*statistics & numerical data MH - Patient Education as Topic MH - Self Care/*instrumentation MH - Telemedicine/*instrumentation OTO - NOTNLM OT - Adherence OT - Chronic illness OT - Feedback OT - Gout OT - Mobile apps OT - Patient centred OT - Self-management EDAT- 2016/08/31 06:00 MHDA- 2017/11/29 06:00 CRDT- 2016/08/31 06:00 PHST- 2015/09/25 00:00 [received] PHST- 2016/06/27 00:00 [revised] PHST- 2016/06/29 00:00 [accepted] PHST- 2016/08/31 06:00 [entrez] PHST- 2016/08/31 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] AID - S1386-5056(16)30150-2 [pii] AID - 10.1016/j.ijmedinf.2016.06.021 [doi] PST - ppublish SO - Int J Med Inform. 2016 Oct;94:67-74. doi: 10.1016/j.ijmedinf.2016.06.021. Epub 2016 Jun 30. PMID- 26503977 OWN - NLM STAT- MEDLINE DCOM- 20161220 LR - 20161230 IS - 1471-8405 (Electronic) IS - 0962-7480 (Linking) VI - 65 IP - 8 DP - 2015 Nov TI - The utility of information collected by occupational disease surveillance systems. PG - 626-31 LID - 10.1093/occmed/kqv138 [doi] AB - BACKGROUND: The Health and Occupation Research (THOR) network in the UK and the Republic of Ireland (ROI) is an integrated system of surveillance schemes collecting work-related ill-health (WRIH) data since 1989. In addition to providing information about disease incidence, trends in incidence and the identification of new hazards, THOR also operates an ad hoc data enquiry service enabling interested parties to request information about cases of WRIH reported to THOR. AIMS: To examine requests for information made to a network of surveillance schemes for WRIH in the UK. METHODS: Analysis via SPSS of data requests received by THOR between 2002 and 2014. RESULTS: A total of 631 requests were received by THOR between 2002 and 2014. Requests were predominantly submitted by participating THOR physicians (34%) and the main THOR funder-the UK Health & Safety Executive (HSE) (31%). The majority (67%) of requests were for information about work-related respiratory or skin disease with relatively few requests for other diagnoses, such as musculoskeletal or mental ill-health. Requests frequently related to a specific industry and/or occupation (42%) and/or a specific causal agent (58%). CONCLUSIONS: Data collected by occupational disease surveillance systems such as THOR are an extremely useful source of information, the use of which extends beyond informing government on disease incidence and trends in incidence. The data collected provide a framework that can assist a wide range of enquirers with clinical diagnoses, identification of suspected causative agents/exposures and to highlight growing risks in particular industrial and occupational sectors. CI - © The Author 2015. Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Money, A AU - Money A AD - Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, The University of Manchester, Manchester M13 9PL, UK. annemarie.money@manchester.ac.uk. FAU - Carder, M AU - Carder M AD - Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, The University of Manchester, Manchester M13 9PL, UK. FAU - Hussey, L AU - Hussey L AD - Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, The University of Manchester, Manchester M13 9PL, UK. FAU - Agius, R M AU - Agius RM AD - Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, The University of Manchester, Manchester M13 9PL, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Occup Med (Lond) JT - Occupational medicine (Oxford, England) JID - 9205857 SB - IM MH - Data Collection MH - Humans MH - Incidence MH - Industry/*statistics & numerical data MH - Ireland/epidemiology MH - Mental Disorders/*epidemiology/etiology/prevention & control MH - Musculoskeletal Diseases/*epidemiology/etiology/prevention & control MH - *Occupational Diseases/epidemiology/prevention & control MH - Occupational Health Services/*organization & administration/statistics & numerical data MH - *Population Surveillance MH - Referral and Consultation MH - Respiratory Tract Diseases/*epidemiology/prevention & control MH - Safety Management/*statistics & numerical data MH - Skin Diseases/*epidemiology/etiology/prevention & control MH - United Kingdom/epidemiology OTO - NOTNLM OT - Impact OT - surveillance OT - utility OT - work-related ill-health. EDAT- 2015/10/28 06:00 MHDA- 2016/12/21 06:00 CRDT- 2015/10/28 06:00 PHST- 2015/10/28 06:00 [entrez] PHST- 2015/10/28 06:00 [pubmed] PHST- 2016/12/21 06:00 [medline] AID - kqv138 [pii] AID - 10.1093/occmed/kqv138 [doi] PST - ppublish SO - Occup Med (Lond). 2015 Nov;65(8):626-31. doi: 10.1093/occmed/kqv138. PMID- 16597512 OWN - NLM STAT- MEDLINE DCOM- 20060720 LR - 20161020 IS - 1440-2440 (Print) IS - 1878-1861 (Linking) VI - 9 IP - 1-2 DP - 2006 May TI - Prevalence of hot weather conditions related to sports participation guidelines: a South Australian investigation. PG - 72-80 AB - BACKGROUND: There is scant guidance in the literature on the most appropriate Australian measures of, and thresholds for, extreme heat regarding giving advice on safe sports participation in hot weather. The purpose of this paper is to present a process for investigating two common measures of heat (air temperature, wet bulb globe temperature (WGBT)) in one state in Australia (South Australia), regarding their usefulness in making decisions regarding sports participation in the heat. METHOD: Commonly reported measures and thresholds of extreme heat were identified from a systematic review of guidelines regarding sports participation in hot weather. Dry air temperature (threshold of 35 degrees C), and WBGT index (threshold of 28 degrees C) were highlighted. Repeated daily measures of dry air temperature by the Bureau of Meteorology (BoM) and WBGT index from 12 meteorological recording sites in South Australia (SA) for four consecutive summer periods (2000-2004) were analysed using these thresholds to investigate the prevalence of extremely hot temperatures in SA during these periods. The extremely hot hours-per-day data were standardised using a denominator of per-day-month across the 12 SA recording regions. RESULTS: Across the four summer seasons of data in SA, there were similar standardised numbers of hours-per-day of extremely hot dry air temperature and WBGT index. There was a high correlation between these hours of hot weather measures, highlighting the congruence between hot air and humidity measures. Three distinct regional site groupings were identified, in which there was a different prevalence of extremely hot weather conditions. CONCLUSION: In SA, dry air temperature is an appropriate and robust measure of extreme heat related to sports participation, this measure providing as much information as WBGT in identifying extremely hot periods of weather. Dry air temperature can be readily measured by sports participants or officials irrespective of the geographical location in SA. Three SA regions demonstrated distinct differences in prevalence of extremely hot conditions, suggesting the need for site-specific interpretation of heat participation guidelines to ensure sports safety in hot weather. Other states in Australia could use the approach outlined in this paper to identify the most appropriate measure of extreme heat relevant to local conditions, and to assist in interpreting heat limit guidelines in a local context. FAU - Grimmer, K AU - Grimmer K AD - The Centre for Allied Health Evidence, University of South Australia, City East Campus, North Tce, Adelaide, SA Australia. Karen.grimmer@unisa.edu.au FAU - King, E AU - King E FAU - Larsen, T AU - Larsen T FAU - Farquharson, T AU - Farquharson T FAU - Potter, A AU - Potter A FAU - Sharpe, P AU - Sharpe P FAU - de Wit, H AU - de Wit H LA - eng PT - Comparative Study PT - Journal Article DEP - 20060404 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM MH - Hot Temperature/*adverse effects MH - Humans MH - Seasons MH - South Australia MH - Sports/*standards MH - Weather EDAT- 2006/04/07 09:00 MHDA- 2006/07/21 09:00 CRDT- 2006/04/07 09:00 PHST- 2006/04/07 09:00 [pubmed] PHST- 2006/07/21 09:00 [medline] PHST- 2006/04/07 09:00 [entrez] AID - S1440-2440(06)00019-3 [pii] AID - 10.1016/j.jsams.2006.02.006 [doi] PST - ppublish SO - J Sci Med Sport. 2006 May;9(1-2):72-80. doi: 10.1016/j.jsams.2006.02.006. Epub 2006 Apr 4. PMID- 38232834 OWN - NLM STAT- MEDLINE DCOM- 20240208 LR - 20240208 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 915 DP - 2024 Mar 10 TI - Short-term high temperature may increase the incidence risk of collective conflicts: A case-crossover study in the Greater Middle East. PG - 170105 LID - S0048-9697(24)00239-0 [pii] LID - 10.1016/j.scitotenv.2024.170105 [doi] AB - BACKGROUND: Violent conflict is a formidable global challenge, with long-lasting impacts on individual health and society security. There has been compelling evidence that heat can increase aggression intention on the individual level. However, little is known about the short-term relationship between ambient temperature and collective violent conflicts, especially in less developed regions. METHOD: We conducted a time-stratified case-crossover study combined with the distributed lag nonlinear model (DLNM) among 247,773 violent conflicts from 29 countries or regions in the Greater Middle East, between 1997 and 2021. Potential modification effects of economic status and climate conditions were explored by stratified analyses. Negative control and sensitivity analyses were also performed to test the robustness of our model. RESULTS: We observed significant associations between higher temperature and the onset of five categories of violent conflicts. The effects generally occurred within the first several days after exposure. The incidence risks of battles, violence against civilians, explosions/remote violence, protests and riots were 1.60 [95 % confidence interval (CI): 1.31-1.95], 1.82 (95 % CI: 1.37-2.42), 1.24 (95 % CI: 1.08-1.41), 1.16 (95 % CI: 1.09-1.24) and 1.54 (95 % CI: 1.22-1.95) when comparing extreme high temperatures to minimum-risk temperatures. The associations were generally more prominent in areas with lower economic levels and associations in regions of the continental climate are also stronger. CONCLUSIONS: Our finding reveals novel and concrete evidence that short-term high temperature could increase the risk of multiple forms of violent conflict in the Greater Middle East and provides new insights into the potential short-term mechanisms under the heat-collective violence association. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Guo, Yichen AU - Guo Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China. FAU - Gao, Ya AU - Gao Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China. FAU - He, Cheng AU - He C AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China. FAU - Zhu, Yixiang AU - Zhu Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China. FAU - Zhou, Lu AU - Zhou L AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. Electronic address: chenrenjie@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20240115 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - Temperature MH - Cross-Over Studies MH - Incidence MH - *Hot Temperature MH - *Climate OTO - NOTNLM OT - Case-crossover study OT - High temperature OT - Longitudinal study OT - Middle East OT - Violent conflicts COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/01/18 00:42 MHDA- 2024/02/08 06:42 CRDT- 2024/01/17 19:12 PHST- 2023/07/08 00:00 [received] PHST- 2024/01/04 00:00 [revised] PHST- 2024/01/09 00:00 [accepted] PHST- 2024/02/08 06:42 [medline] PHST- 2024/01/18 00:42 [pubmed] PHST- 2024/01/17 19:12 [entrez] AID - S0048-9697(24)00239-0 [pii] AID - 10.1016/j.scitotenv.2024.170105 [doi] PST - ppublish SO - Sci Total Environ. 2024 Mar 10;915:170105. doi: 10.1016/j.scitotenv.2024.170105. Epub 2024 Jan 15. PMID- 32994513 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201103 LR - 20210929 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 10 IP - 1 DP - 2020 Sep 29 TI - Systematic experimental investigation of the obstacle effect during non-competitive and extremely competitive evacuations. PG - 15947 LID - 10.1038/s41598-020-72733-w [doi] LID - 15947 AB - Although some experimental evidence showed that an obstacle placed in front of a door allows making people's evacuations faster, the efficacy of such a solution has been debated for over 15 years. Researchers are split between those who found the obstacle beneficial and those who could not find a significant difference without it. One of the reasons for the several conclusions lies in the variety of the experiments performed so far, both in terms of competitiveness among participants, geometrical configuration and number of participants. In this work, two unique datasets relative to evacuations with/without obstacle and comprising low and high competitiveness are analyzed using state-of-the-art definitions for crowd dynamics. In particular, the so-called congestion level is employed to measure the smoothness of collective motion. Results for extreme conditions show that, on the overall, the obstacle does not reduce density and congestion level and it could rather slightly increase it. From this perspective, the obstacle was found simply shifting the dangerous spots from the area in front of the exit to the regions between the obstacle and the wall. On the other side, it was however confirmed, that the obstacle can stabilize longitudinal crowd waves, thus reducing the risk of trampling, which could be as important (in terms of safety) as improving the evacuation time. However, under urgent, competitive, but non-extreme conditions, the obstacle generally had a positive effect, helping channeling the flow of pedestrians through the exit while facilitating their interactions. FAU - Feliciani, Claudio AU - Feliciani C AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. feliciani@jamology.rcast.u-tokyo.ac.jp. FAU - Zuriguel, Iker AU - Zuriguel I AD - Departamento de Física y Matemática Aplicada, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain. FAU - Garcimartín, Angel AU - Garcimartín A AD - Departamento de Física y Matemática Aplicada, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain. FAU - Maza, Diego AU - Maza D AD - Departamento de Física y Matemática Aplicada, Facultad de Ciencias, Universidad de Navarra, Pamplona, Spain. FAU - Nishinari, Katsuhiro AU - Nishinari K AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, 153-8904, Japan. AD - Department of Aeronautics and Astronautics, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200929 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC7525554 COIS- The authors declare no competing interests. EDAT- 2020/10/01 06:00 MHDA- 2020/10/01 06:01 PMCR- 2020/09/29 CRDT- 2020/09/30 06:09 PHST- 2020/05/19 00:00 [received] PHST- 2020/09/04 00:00 [accepted] PHST- 2020/09/30 06:09 [entrez] PHST- 2020/10/01 06:00 [pubmed] PHST- 2020/10/01 06:01 [medline] PHST- 2020/09/29 00:00 [pmc-release] AID - 10.1038/s41598-020-72733-w [pii] AID - 72733 [pii] AID - 10.1038/s41598-020-72733-w [doi] PST - epublish SO - Sci Rep. 2020 Sep 29;10(1):15947. doi: 10.1038/s41598-020-72733-w. PMID- 23786144 OWN - NLM STAT- MEDLINE DCOM- 20130725 LR - 20190911 IS - 1096-2247 (Print) IS - 1096-2247 (Linking) VI - 63 IP - 5 DP - 2013 May TI - Effect of calibration environment on the performance of direct-reading organic vapor monitors. PG - 528-33 AB - The performance of two direct-reading organic vapor monitors (monitors) when calibrated at different environmental conditions was compared with charcoal tube results. Three MIRAN SapphIRe portable ambient air analyzers (SAP) and three Century portable toxic vapor analyzers (TVAs) were evaluated. Prior to sampling, the monitors were calibrated per the manufacturer's instructions using methane for the TVA flame ionization detector (FID) and isobutylene for the photoionization detector (PID), whereas the SapphIRe instruments were zeroed and the instrument's manufacturer-supplied library was used. For the first series of tests ("Part 1--Same condition"), the monitors were calibrated under the same environmental conditions as those present during sampling. They were then challenged with four cyclohexane concentrations (30, 150, 300, and 475 ppm) under two extreme environmental conditions: 5 degrees C and 30% relative humidity (RH) (same/cold) and 38 degrees C and 90% RH (same/hot). For the second series of tests ("Part 2--Different condition"), the monitors were calibrated at approximately normal indoor environmental conditions (21 degrees C and 50% RH) and sampled at extreme environmental conditions (different/cold and different/hot). The monitor readings from the two methods were compared with the actual cyclohexane concentration determined from charcoal tubes using ratios and root mean square errors. A number of monitor failures, both below detection limit values in the presence of a known challenge concentration and erroneously high measurements, occurred in each part: same condition 20.7% (149/720) and different condition 42.4% (305/ 720), with a majority of the failures (> 78%) during the hot and humid conditions. All monitors performed best at the same/cold, followed by the same/hot, in terms of closeness to the reference standard method and low within-monitor variability. The ranked choice of monitors for same/cold is PID > SAP > FID; for different/cold FID > PID > SAP; for same/hot SAP > PID > FID; and for different/hot PID > SAP (FID not included due to 100% failure rate). IMPLICATIONS: Direct-reading organic vapor monitors are used for assessing the concentrations of volatile organic compounds in the air at varying environmental conditions. Typical calibration is performed at laboratory temperature and pressure. The monitors may be used in atmospheres that differ from that during calibration. An understanding of the effect of calibration environment on monitor performance may provide valuable information on the reliability and appropriateness of certain monitor types for industrial hygienists, emergency responders, and exposure assessment practitioners. Results of the study indicate monitor calibration should be performed at the same environmental conditions as sampling. FAU - LeBouf, Ryan F AU - LeBouf RF AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. rlebouf@cdc.gov FAU - Slaven, James E AU - Slaven JE FAU - Coffey, Christopher C AU - Coffey CC LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Air Waste Manag Assoc JT - Journal of the Air & Waste Management Association (1995) JID - 9503111 RN - 0 (Air Pollutants) RN - 0 (Gases) SB - IM MH - Air Pollutants/*analysis MH - Calibration MH - Environmental Monitoring/*instrumentation MH - Gases/*analysis MH - Humidity MH - Temperature EDAT- 2013/06/22 06:00 MHDA- 2013/07/26 06:00 CRDT- 2013/06/22 06:00 PHST- 2013/06/22 06:00 [entrez] PHST- 2013/06/22 06:00 [pubmed] PHST- 2013/07/26 06:00 [medline] AID - 10.1080/10962247.2013.772926 [doi] PST - ppublish SO - J Air Waste Manag Assoc. 2013 May;63(5):528-33. doi: 10.1080/10962247.2013.772926. PMID- 9584808 OWN - NLM STAT- MEDLINE DCOM- 19980710 LR - 20191210 IS - 0196-6553 (Print) IS - 0196-6553 (Linking) VI - 26 IP - 2 DP - 1998 Apr TI - Tuberculosis control through respirator wear: performance of National Institute for Occupational Safety and Health-regulated respirators. PG - 139-42 AB - BACKGROUND: In 1995 the National Institute for Occupational Safety and Health issued new rules for personal respirators. All nine new respirator categories are authorized in health care facilities for the prevention of the transmission of tuberculosis (TB). The new N95 respirator category is the most frequently used for this purpose. Data are presented on their efficiency for collecting TB-size bacteria and their potential for reaerosolizing collected bacteria. METHODS: All measurements of bacterial penetration were performed with dynamic aerosol size spectrometers at flow conditions corresponding to normal wear and respirator certification conditions. The reaerosolization tests were performed at conditions ranging from normal breathing to violent coughing or sneezing. RESULTS: The tested N95 respirators collected 0.1 to 0.3 microm particles with efficiencies of 95% or higher, as specified by the regulations. TB-size bacteria of 0.8 microm and larger, however, were collected with 99.5% or higher efficiencies; that is, the penetration of these bacteria through the filter material was 0.5% or less, much less than the required maximum penetration of 5% for the smaller particle sizes. No bacteria were reaerosolized during normal exhalation. Some reaerosolization (0.1% or less) was observed only at low humidity and extremely high air flow through the respirator, corresponding to violent coughing or sneezing. CONCLUSIONS: The filter materials of N95 respirators provide good protection against TB bacteria. Thus, a significant number of bacteria can enter the respirator-wearer's breathing space only through spaces where the respirator inadequately seals to the wearer's face. Reentrainment and reaerosolization of mycobacteria is not a problem when normal work practices are observed in health care facilities. FAU - Willeke, K AU - Willeke K AD - Department of Environmental Health, University of Cincinnati, OH 45267-0056, USA. FAU - Qian, Y AU - Qian Y LA - eng GR - R01-OH-03244/OH/NIOSH CDC HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Am J Infect Control JT - American journal of infection control JID - 8004854 SB - IM MH - Equipment Contamination MH - Health Facilities MH - Humans MH - Infection Control/methods MH - Infectious Disease Transmission, Patient-to-Professional/*prevention & control MH - National Institute for Occupational Safety and Health, U.S./*standards MH - Respiratory Protective Devices/microbiology/*standards MH - Tuberculosis, Multidrug-Resistant/prevention & control/*transmission MH - United States EDAT- 1998/05/19 00:00 MHDA- 1998/05/19 00:01 CRDT- 1998/05/19 00:00 PHST- 1998/05/19 00:00 [pubmed] PHST- 1998/05/19 00:01 [medline] PHST- 1998/05/19 00:00 [entrez] AID - S0196655398000303 [pii] AID - 10.1016/s0196-6553(98)80033-3 [doi] PST - ppublish SO - Am J Infect Control. 1998 Apr;26(2):139-42. doi: 10.1016/s0196-6553(98)80033-3. PMID- 4012237 OWN - NLM STAT- MEDLINE DCOM- 19850729 LR - 20190919 IS - 0036-5580 (Print) IS - 0036-5580 (Linking) VI - 19 IP - 1 DP - 1985 TI - The monostrut strength. PG - 13-9 AB - The fatigue endurance limit for Haynes 25 from which the Björk-Shiley (B-S) valve is made is 4900 kg per square centimeter (70000 pounds per square inch). A welded strut may have a variation of fatigue endurance limit from 4900 kg per square centimeter (70000 pounds per square inch) in an incomplete weld with phase segregation. To avoid a weld with this variation, the monostrut has been developed, where the valve is made by electrochemical machining from one piece of Haynes 25. The homogenous outflow monostrut will then have a stable fatigue endurance limit of 4900 kg per square centimeter (70000 pounds per square inch). In a pulse duplicator at a pulse rate of 120 and a peak ventricular pressure of 200 mmHg, the maximum inservice tensile stresses for the 29 mm valve outflow strut do not exceed 700 kg per square centimeter (9800 pounds per square inch). Therefore, a seven times safety limit is present for the monostrut under maximal physiological stress conditions. The struts in the B-S monostrut valve cannot be fractured even under extreme experimental conditions and never under peak physiological conditions. FAU - Björk, V O AU - Björk VO FAU - Lindblom, D AU - Lindblom D FAU - Henze, A AU - Henze A LA - eng PT - Journal Article PL - Sweden TA - Scand J Thorac Cardiovasc Surg JT - Scandinavian journal of thoracic and cardiovascular surgery JID - 0121343 SB - IM MH - Equipment Design/*standards MH - Equipment Safety MH - Heart Valve Prosthesis/*standards MH - Humans EDAT- 1985/01/01 00:00 MHDA- 1985/01/01 00:01 CRDT- 1985/01/01 00:00 PHST- 1985/01/01 00:00 [pubmed] PHST- 1985/01/01 00:01 [medline] PHST- 1985/01/01 00:00 [entrez] AID - 10.3109/14017438509102815 [doi] PST - ppublish SO - Scand J Thorac Cardiovasc Surg. 1985;19(1):13-9. doi: 10.3109/14017438509102815. PMID- 39663343 OWN - NLM STAT- Publisher LR - 20241211 IS - 1525-1497 (Electronic) IS - 0884-8734 (Linking) DP - 2024 Dec 11 TI - Novel Method for Measuring Ambient Heat Exposure-Acute Healthcare Utilization Associations Within a Safety Net: A Retrospective, Longitudinal Study. LID - 10.1007/s11606-024-09231-6 [doi] AB - BACKGROUND: Extreme and inequitable heat exposures cause weather-related deaths. Associations between maximum daily temperature and individual-level healthcare utilization have been inadequately characterized. OBJECTIVE: To evaluate and compare demographic and clinical associations for an individual's healthcare utilization between high- and low-temperature periods. DESIGN: Retrospective, 5-year longitudinal study of acute care utilization comparing high-temperature periods (HHP) and low-temperature periods (LHP) defined by local maximum daily temperature. Using duration of observation, cases served as their own controls. Temperature-dependent utilization was reported as unadjusted incident rate ratio (IRR) using Poisson regression and log-transformed variable coefficients. IRRs were adjusted (aIRR) for demographic characteristics, heat-sensitive conditions/diagnoses, and neighborhood heat vulnerability score; false discovery rate p-values were adjusted for multiple comparisons. SUBJECTS: Patients aged ≥ 4 years visiting Denver Health between 4/10/2016 and 12/31/2020, with ≥ 2 visits over ≥ 365 days. MAIN MEASURES: Comparison of an individual's acute care visit rates in HHP versus LHP, stratified by demographic characteristics and heat-sensitive clinical conditions. KEY RESULTS: While acute care utilization occurred at similar or higher rates during LHP compared with HHP, certain groups (i.e., Native Americans and those with congestive heart failure, liver failure, and/or alcohol use) had higher rates of utilization during HHP. Significant associations existed for acute care utilization by age, sex, racial and ethnic groupings, clinical characteristics, and neighborhood heat vulnerability. Adjusting for demographic and environmental covariates, individuals with any heat-sensitive clinical condition had higher HHP vs LHP utilization compared to those without (aIRR = 1.93). CONCLUSIONS: Significant heat-related utilization occurred among individuals with heat-sensitive clinical conditions compared with those without. Demographic characteristics (e.g., older) and specific clinical conditions (e.g., liver failure) demonstrated higher utilization. In real-time, chronic disease management programs could proactively identify at-risk individuals for interventions which reduce heat-related morbidity and healthcare utilization. CI - © 2024. The Author(s), under exclusive licence to Society of General Internal Medicine. FAU - Gillespie, Elizabeth AU - Gillespie E AUID- ORCID: 0000-0002-2757-8887 AD - Denver Health Medical Center, Denver, CO, USA. Elizabeth.Gillespie@dhha.org. AD - University of Colorado School of Medicine, Aurora, CO, USA. Elizabeth.Gillespie@dhha.org. FAU - Steiner, Abigail AU - Steiner A AD - Denver Health Center for Health Systems Research, Denver, CO, USA. FAU - Durfee, Josh AU - Durfee J AD - Denver Health Center for Health Systems Research, Denver, CO, USA. FAU - Scott, Kenneth AU - Scott K AD - Colorado School of Public Health, Aurora, CO, USA. FAU - Stein, Amy AU - Stein A AD - Denver Health Center for Health Systems Research, Denver, CO, USA. FAU - Davidson, Arthur J AU - Davidson AJ AD - Denver Health Medical Center, Denver, CO, USA. AD - University of Colorado School of Medicine, Aurora, CO, USA. AD - Colorado School of Public Health, Aurora, CO, USA. LA - eng PT - Journal Article DEP - 20241211 PL - United States TA - J Gen Intern Med JT - Journal of general internal medicine JID - 8605834 SB - IM OTO - NOTNLM OT - climate change OT - healthcare utilization OT - heat COIS- Declarations:. Conflict of Interest:: The authors declare that they do not have a conflict of interest. EDAT- 2024/12/12 00:24 MHDA- 2024/12/12 00:24 CRDT- 2024/12/11 23:22 PHST- 2024/03/08 00:00 [received] PHST- 2024/11/20 00:00 [accepted] PHST- 2024/12/12 00:24 [medline] PHST- 2024/12/12 00:24 [pubmed] PHST- 2024/12/11 23:22 [entrez] AID - 10.1007/s11606-024-09231-6 [pii] AID - 10.1007/s11606-024-09231-6 [doi] PST - aheadofprint SO - J Gen Intern Med. 2024 Dec 11. doi: 10.1007/s11606-024-09231-6. PMID- 15578987 OWN - NLM STAT- MEDLINE DCOM- 20050331 LR - 20191109 IS - 1566-5232 (Print) IS - 1566-5232 (Linking) VI - 4 IP - 4 DP - 2004 Dec TI - Why do we need new gene therapy viral vectors? Characteristics, limitations and future perspectives of viral vector transduction. PG - 357-72 AB - The use of viruses to transduce genes of interest into mammalian cells has been extremely revolutionary, both in terms of laboratory research and for clinical purposes. This approach has allowed expression and over-expression of proteins of interest as well as the understanding of both virus life cycles and eukaryotic cell mechanisms. Beginning in the late eighties gene transduction has been applied to clinical trials but mainly restricted to cancer treatment and genetic diseases. More recently it has been proposed for the cure of infectious diseases (AIDS), vascular diseases and others (Alzheimer's and Parkinson's disease). Viral vectors have been progressively modified in order to increase their transduction efficiency and to reduce their toxicity, immunogenicity and inflammatory potential. In this respect, much has been done in the last few years. By adding genes belonging to other viral species to the vectors' DNA, scientists were able to re-direct their tissue-specificity or to control protein expression. More recently, in the attempt of overcoming the limitations of each viral species, so-called chimeric viral vectors have been generated by combining favourable features of two or more different viruses into one. This review summarises the main characteristics of the most common viral vectors, including their advantages, limitations and possible future applications. It also briefly discusses development and evolution of chimeric vectors, treated in more details along this entire issue. Finally, we evaluate basic safety aspects, mandatory to consider for the clinical application of viral gene transduction. FAU - Tomanin, R AU - Tomanin R AD - Gene Therapy Laboratory, Center for Rare Diseases and Dept. of Pediatrics, University of Padova, Padova, Italy. tomanin@mail.bio.unipd.it FAU - Scarpa, M AU - Scarpa M LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Gene Ther JT - Current gene therapy JID - 101125446 SB - IM MH - Adenoviridae/genetics MH - Animals MH - Chimera/genetics MH - Dependovirus/genetics MH - Genetic Therapy/adverse effects/*methods/trends MH - *Genetic Vectors MH - Herpesviridae/genetics MH - Humans MH - Safety MH - Transduction, Genetic RF - 217 EDAT- 2004/12/08 09:00 MHDA- 2005/04/01 09:00 CRDT- 2004/12/08 09:00 PHST- 2004/12/08 09:00 [pubmed] PHST- 2005/04/01 09:00 [medline] PHST- 2004/12/08 09:00 [entrez] AID - 10.2174/1566523043346011 [doi] PST - ppublish SO - Curr Gene Ther. 2004 Dec;4(4):357-72. doi: 10.2174/1566523043346011. PMID- 24674432 OWN - NLM STAT- MEDLINE DCOM- 20150218 LR - 20230307 IS - 1944-9097 (Electronic) IS - 0362-028X (Linking) VI - 77 IP - 3 DP - 2014 Mar TI - Analysis of microbiological contamination in mixed pressed ham and cooked sausage in Korea. PG - 412-8 LID - 10.4315/0362-028X.JFP-13-322 [doi] AB - The objective of this study was to investigate the microbial contamination levels (aerobic bacteria plate count [APC], coliforms, Escherichia coli, Staphylococcus aureus, and Listeria monocytogenes) in mixed pressed ham and cooked sausage. A total of 180 samples were collected from factories with and without hazard analysis critical control point (HACCP) systems at four steps: after chopping (AC), after mixing (AM), cooling after the first heating process, and cooling after the second heating process. For ham, APCs and coliform and E. coli counts increased when ingredients were added to the meat at the AC step. Final product APC was 1.63 to 1.85 log CFU/g, and coliforms and E. coli were not detected. S. aureus and L. monocytogenes were found in nine (15.0%) and six (10.0%) samples, respectively, but only at the AC and AM steps and not in the final product. Sausage results were similar to those for ham. The final product APC was 1.52 to 3.85 log CFU/g, and coliforms and E. coli were not detected. S. aureus and L. monocytogenes were found in 29 (24.2%) and 25 (20.8%) samples at the AC and AM steps, respectively, but not in the final product. These results indicate that the temperature and time of the first and second heating are of extreme importance to ensure the microbiological safety of the final product regardless of whether a HACCP system is in place. Microorganism contamination must be monitored regularly and regulations regarding sanitization during processing should be improved. Education regarding employee personal hygiene, environmental hygiene, prevention of cross-contamination, ingredient control, and step-by-step process control is needed to reduce the risk of food poisoning. FAU - Park, Myoung-Su AU - Park MS AD - Department of Food Science and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. FAU - Wang, Jun AU - Wang J AD - Department of Food Science and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. FAU - Park, Joong-Hyun AU - Park JH AD - Department of Food Science and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. FAU - Forghani, Fereidoun AU - Forghani F AD - Department of Food Science and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. FAU - Moon, Jin-San AU - Moon JS AD - Department of Animal Disease Control & Quarantine, Animal and Plant Quarantine Agency, Anyang, Gyeonggi, 430-824, South Korea. FAU - Oh, Deog-Hwan AU - Oh DH AD - Department of Food Science and Biotechnology and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea. deoghwa@kangwon.ac.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Food Prot JT - Journal of food protection JID - 7703944 SB - IM MH - Animals MH - Colony Count, Microbial MH - Consumer Product Safety MH - Cooking MH - Escherichia coli/isolation & purification MH - Food Contamination/*analysis/prevention & control MH - Food Handling/*methods MH - Hazard Analysis and Critical Control Points MH - *Hygiene MH - Listeria monocytogenes/isolation & purification MH - Meat Products/*microbiology MH - Republic of Korea MH - Staphylococcus aureus/isolation & purification MH - Swine MH - Temperature MH - Time Factors EDAT- 2014/03/29 06:00 MHDA- 2015/02/19 06:00 CRDT- 2014/03/29 06:00 PHST- 2014/03/29 06:00 [entrez] PHST- 2014/03/29 06:00 [pubmed] PHST- 2015/02/19 06:00 [medline] AID - S0362-028X(23)06287-7 [pii] AID - 10.4315/0362-028X.JFP-13-322 [doi] PST - ppublish SO - J Food Prot. 2014 Mar;77(3):412-8. doi: 10.4315/0362-028X.JFP-13-322. PMID- 19305501 OWN - NLM STAT- MEDLINE DCOM- 20090424 LR - 20211020 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 4 IP - 3 DP - 2009 TI - Psychological typhoon eye in the 2008 Wenchuan earthquake. PG - e4964 LID - 10.1371/journal.pone.0004964 [doi] LID - e4964 AB - BACKGROUND: On May 12, 2008, an earthquake measuring 8.0 on the Richter scale jolted Wenchuan, China, leading to 69,227 deaths and 374,643 injured, with 17,923 listed as missing as of Sept. 25, 2008, and shook the whole nation. We assessed the devastating effects on people's post-earthquake concern about safety and health. METHODOLOGY/PRINCIPAL FINDINGS: From June 4 to July 15, 2008, we surveyed a convenience sample of 2,262 adults on their post-earthquake concern about safety and health. Residents in non-devastated areas (Fujian and Hunan Provinces, and Beijing) and devastated areas (Sichuan and Gansu Provinces) responded to a questionnaire of 5 questions regarding safety measures, epidemic disease, medical workers, psychological workers, and medication. The ANOVAs showed a significant effect of residential devastation level on the estimated number of safety measures needed, the estimated probability of the outbreak of an epidemic, and the estimated number of medical and psychological workers needed (Ps<0.001). The post-earthquake concern decreased significantly as the level of residential devastation increased. Because of the similarity with the meteorological phenomenon of the eye of a typhoon, we dubbed these findings a "Psychological Typhoon Eye": the closer to the center of the devastated areas, the less the concern about safety and health a resident felt. CONCLUSIONS/SIGNIFICANCE: Contrary to common perception and ripple effect that the impact of an unfortunate event decays gradually as ripples spread outward from a center, a "Psychological Typhoon Eye" effect was observed where the post-earthquake concern was at its lowest level in the extremely devastated areas. The resultant findings may have implications for Chinese governmental strategies for putting "psychological comfort" into effect. FAU - Li, Shu AU - Li S AD - Institute of Psychology, Chinese Academy of Sciences, Beijing, China. FAU - Rao, Li-Lin AU - Rao LL FAU - Ren, Xiao-Peng AU - Ren XP FAU - Bai, Xin-Wen AU - Bai XW FAU - Zheng, Rui AU - Zheng R FAU - Li, Jin-Zhen AU - Li JZ FAU - Wang, Zuo-Jun AU - Wang ZJ FAU - Liu, Huan AU - Liu H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090323 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Child MH - China MH - *Data Collection MH - *Earthquakes MH - Emergency Medical Services MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Safety MH - Stress Disorders, Post-Traumatic MH - Stress, Psychological/*psychology MH - Surveys and Questionnaires MH - Young Adult PMC - PMC2654756 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2009/03/24 09:00 MHDA- 2009/04/25 09:00 PMCR- 2009/03/23 CRDT- 2009/03/24 09:00 PHST- 2008/10/24 00:00 [received] PHST- 2009/02/24 00:00 [accepted] PHST- 2009/03/24 09:00 [entrez] PHST- 2009/03/24 09:00 [pubmed] PHST- 2009/04/25 09:00 [medline] PHST- 2009/03/23 00:00 [pmc-release] AID - 08-PONE-RA-07006R1 [pii] AID - 10.1371/journal.pone.0004964 [doi] PST - ppublish SO - PLoS One. 2009;4(3):e4964. doi: 10.1371/journal.pone.0004964. Epub 2009 Mar 23. PMID- 38668140 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240429 IS - 2409-9279 (Electronic) IS - 2409-9279 (Linking) VI - 7 IP - 2 DP - 2024 Apr 11 TI - Research and Simulation on the Development of a Hydraulic Prop Support System of Powered Roof Support to Increase Work Safety. LID - 10.3390/mps7020033 [doi] LID - 33 AB - The underground mining environment is currently based on technology that uses mainly analogue sensors in machine and equipment control systems. The primary machine performing the most important functions in a mining system is the powered roof support. In order for it to work properly, it is important that it achieves the required power. To ensure this, it is necessary to continuously and precisely monitor the pressure in the under-piston space of the prop. Due to the extreme environmental conditions, pressure sensors should have high sensitivity, large transmission capacity, small size and light weight. To achieve these requirements, the authors of the article propose to implement a monitoring system based on photonics technology. To achieve this goal, several studies were carried out. The range of these studies included simulations, bench tests and tests under real conditions. The obtained test results showed the possibility of developing the control system for the powered roof support, the additional function to supercharge power. Based on the analysis of the obtained test results, assumptions were developed for the development of a power charging system with monitoring sensors. Based on the guidelines obtained from the research results, thedevelopment of the above prototype based on photonics technology is proposed. FAU - Borska, Beata AU - Borska B AD - KWK Ruda Ruch Halemba, ul. Halembska 160, 41-717 Ruda Śląska, Poland. FAU - Szurgacz, Dawid AU - Szurgacz D AUID- ORCID: 0000-0002-5733-2327 AD - Center of Hydraulics DOH Ltd., ul. Konstytucji 147, 41-906 Bytom, Poland. AD - Polska Grupa Górnicza S.A., ul. Powstańców 30, 40-039 Katowice, Poland. LA - eng PT - Journal Article DEP - 20240411 PL - Switzerland TA - Methods Protoc JT - Methods and protocols JID - 101720073 PMC - PMC11054605 OTO - NOTNLM OT - bench tests OT - extreme mining environmental monitoring OT - optical sensors OT - simulations OT - tests under real conditions COIS- Author Dawid Szurgacz is employed by the Center of Hydraulics DOH Ltd. and Polska Grupa Górnicza S.A. Authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/04/26 13:21 MHDA- 2024/04/26 13:22 PMCR- 2024/04/11 CRDT- 2024/04/26 09:33 PHST- 2024/02/21 00:00 [received] PHST- 2024/03/30 00:00 [revised] PHST- 2024/04/03 00:00 [accepted] PHST- 2024/04/26 13:22 [medline] PHST- 2024/04/26 13:21 [pubmed] PHST- 2024/04/26 09:33 [entrez] PHST- 2024/04/11 00:00 [pmc-release] AID - mps7020033 [pii] AID - mps-07-00033 [pii] AID - 10.3390/mps7020033 [doi] PST - epublish SO - Methods Protoc. 2024 Apr 11;7(2):33. doi: 10.3390/mps7020033. PMID- 39442843 OWN - NLM STAT- MEDLINE DCOM- 20241206 LR - 20241206 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 282 IP - Pt 1 DP - 2024 Dec TI - Super protective effect, ultra-high juice absorption and long-term antibacterial of Ag-2MI@Chitosan biodegradable sponge for fruit preservation and transportation. PG - 136526 LID - S0141-8130(24)07335-5 [pii] LID - 10.1016/j.ijbiomac.2024.136526 [doi] AB - Plastic foam packaging is often used for the transportation to avoid mechanical damage to the fruit, but it lacks antibacterial properties, water absorption and is non-degradable, leading to fruit decay and safety risks as well as serious environmental pollution. Herein, Ag-2-Methylimidazole@Chitosan (Ag-2MI@CS) was successfully synthesized by in situ synthesis at normal temperature and pressure, and improved the antibacterial performance of Ag-2MI@CS by using green solvent ethanol to adjust the solvent polarity. The results showed that the long-lasting inhibitory performance of Ag-2MI@CS was significantly improved, the long-lasting antibacterial time has been extended from 24 h to 96 h. Furthermore, Ag-2MI@CS can significantly protect fruits and reduce the damage of fruits, even when falling from a height of 60 cm or under extreme transportation conditions. Besides, Ag-2MI@CS had extremely high absorption rates of water and fruit juice, 1447.69 % and 1356.59 %, respectively, which was conducive to absorbing water generated by respiration and juice generated by damage during transportation, so as to avoid the growth of bacteria caused by water and fruit juice. Ag-2MI@CS can achieve fruit preservation in both indoor static and transportation dynamic conditions. This study offers novel insights into new biodegradable packaging material in fruit transportation. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - He, Qiuwen AU - He Q AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. FAU - Zhang, Yuancheng AU - Zhang Y AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. FAU - Zhao, Wenxin AU - Zhao W AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. FAU - Deng, Yongfu AU - Deng Y AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. FAU - Li, Hao AU - Li H AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. FAU - Lin, Baofeng AU - Lin B AD - School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. Electronic address: lbf@gxu.edu.cn. LA - eng PT - Journal Article DEP - 20241021 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 9012-76-4 (Chitosan) RN - 0 (Anti-Bacterial Agents) RN - 3M4G523W1G (Silver) RN - 0 (Imidazoles) SB - IM MH - *Chitosan/chemistry/pharmacology MH - *Anti-Bacterial Agents/pharmacology/chemistry MH - *Food Preservation/methods MH - *Fruit/chemistry MH - *Fruit and Vegetable Juices MH - Silver/chemistry/pharmacology MH - Food Packaging/methods MH - Microbial Sensitivity Tests MH - Imidazoles/chemistry/pharmacology MH - Transportation OTO - NOTNLM OT - Antibacterial sponge OT - Biodegradable OT - Fruit transportation OT - Protection OT - Solvent regulation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/10/24 00:22 MHDA- 2024/12/06 06:23 CRDT- 2024/10/23 19:26 PHST- 2024/08/26 00:00 [received] PHST- 2024/09/29 00:00 [revised] PHST- 2024/10/10 00:00 [accepted] PHST- 2024/12/06 06:23 [medline] PHST- 2024/10/24 00:22 [pubmed] PHST- 2024/10/23 19:26 [entrez] AID - S0141-8130(24)07335-5 [pii] AID - 10.1016/j.ijbiomac.2024.136526 [doi] PST - ppublish SO - Int J Biol Macromol. 2024 Dec;282(Pt 1):136526. doi: 10.1016/j.ijbiomac.2024.136526. Epub 2024 Oct 21. PMID- 27631633 OWN - NLM STAT- MEDLINE DCOM- 20170822 LR - 20240525 IS - 1462-2920 (Electronic) IS - 1462-2912 (Print) IS - 1462-2912 (Linking) VI - 19 IP - 3 DP - 2017 Mar TI - Glycerol enhances fungal germination at the water-activity limit for life. PG - 947-967 LID - 10.1111/1462-2920.13530 [doi] AB - For the most-extreme fungal xerophiles, metabolic activity and cell division typically halts between 0.700 and 0.640 water activity (approximately 70.0-64.0% relative humidity). Here, we investigate whether glycerol can enhance xerophile germination under acute water-activity regimes, using an experimental system which represents the biophysical limit of Earth's biosphere. Spores from a variety of species, including Aspergillus penicillioides, Eurotium halophilicum, Xerochrysium xerophilum (formerly Chrysosporium xerophilum) and Xeromyces bisporus, were produced by cultures growing on media supplemented with glycerol (and contained up to 189 mg glycerol g dry spores(-1) ). The ability of these spores to germinate, and the kinetics of germination, were then determined on a range of media designed to recreate stresses experienced in microbial habitats or anthropogenic systems (with water-activities from 0.765 to 0.575). For A. penicillioides, Eurotium amstelodami, E. halophilicum, X. xerophilum and X. bisporus, germination occurred at lower water-activities than previously recorded (0.640, 0.685, 0.651, 0.664 and 0.637 respectively). In addition, the kinetics of germination at low water-activities were substantially faster than those reported previously. Extrapolations indicated theoretical water-activity minima below these values; as low as 0.570 for A. penicillioides and X. bisporus. Glycerol is present at high concentrations (up to molar levels) in many types of microbial habitat. We discuss the likely role of glycerol in expanding the water-activity limit for microbial cell function in relation to temporal constraints and location of the microbial cell or habitat. The findings reported here have also critical implications for understanding the extremes of Earth's biosphere; for understanding the potency of disease-causing microorganisms; and in biotechnologies that operate at the limits of microbial function. CI - © 2016 The Authors. Environmental Microbiology published by Society for Applied Microbiology and John Wiley & Sons Ltd. FAU - Stevenson, Andrew AU - Stevenson A AD - Institute for Global Food Security, School of Biological Sciences, MBC, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland. FAU - Hamill, Philip G AU - Hamill PG AD - Institute for Global Food Security, School of Biological Sciences, MBC, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland. FAU - Medina, Ángel AU - Medina Á AD - Applied Mycology Group, Cranfield Soil and AgriFood Institute, Cranfield University, Cranfield, Bedford, MK43 OAL, UK. FAU - Kminek, Gerhard AU - Kminek G AD - Independent Safety Office, European Space Agency, 2200 AG Noordwijk, The Netherlands. FAU - Rummel, John D AU - Rummel JD AD - SETI Institute, Mountain View, California, 94043, USA. FAU - Dijksterhuis, Jan AU - Dijksterhuis J AD - CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, Utrecht, CT, 3584, The Netherlands. FAU - Timson, David J AU - Timson DJ AD - School of Pharmacy and Biomolecular Sciences, University of Brighton, Huxley Building, Lewes Road, Brighton, BN2 4GJ, UK. FAU - Magan, Naresh AU - Magan N AD - Applied Mycology Group, Cranfield Soil and AgriFood Institute, Cranfield University, Cranfield, Bedford, MK43 OAL, UK. FAU - Leong, Su-Lin L AU - Leong SL AD - Department of Microbiology, Swedish University of Agricultural Sciences, Box 7025, Uppsala, 75007, Sweden. FAU - Hallsworth, John E AU - Hallsworth JE AD - Institute for Global Food Security, School of Biological Sciences, MBC, Queen's University Belfast, Belfast, BT9 7BL, Northern Ireland. LA - eng GR - BBF0034711/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Journal Article DEP - 20161113 PL - England TA - Environ Microbiol JT - Environmental microbiology JID - 100883692 RN - 059QF0KO0R (Water) RN - PDC6A3C0OX (Glycerol) SB - IM MH - Aspergillus/metabolism MH - Ecosystem MH - Eurotiales/metabolism MH - Fungi/metabolism/*physiology MH - Glycerol/*metabolism MH - Spores, Fungal/metabolism/*physiology MH - Water/*metabolism PMC - PMC5363249 EDAT- 2016/09/16 06:00 MHDA- 2017/08/23 06:00 PMCR- 2017/03/23 CRDT- 2016/09/16 06:00 PHST- 2016/05/05 00:00 [received] PHST- 2016/09/09 00:00 [revised] PHST- 2016/09/12 00:00 [accepted] PHST- 2016/09/16 06:00 [pubmed] PHST- 2017/08/23 06:00 [medline] PHST- 2016/09/16 06:00 [entrez] PHST- 2017/03/23 00:00 [pmc-release] AID - EMI13530 [pii] AID - 10.1111/1462-2920.13530 [doi] PST - ppublish SO - Environ Microbiol. 2017 Mar;19(3):947-967. doi: 10.1111/1462-2920.13530. Epub 2016 Nov 13. PMID- 23886505 OWN - NLM STAT- MEDLINE DCOM- 20140224 LR - 20130726 IS - 1532-9496 (Electronic) IS - 0887-7963 (Linking) VI - 27 IP - 3 DP - 2013 Jul TI - Viral safety of human plasma-derived medicinal products: impact of regulation requirements. PG - 179-83 LID - S0887-7963(13)00035-7 [pii] LID - 10.1016/j.tmrv.2013.05.002 [doi] AB - The viral safety of plasma-derived medicinal products is of paramount importance. This article aims to provide insight into the relative impact of different safety measures on achieving viral safety of finished products, derived from human plasma. Virus removal and/or inactivation during the production process is the most important safety measure, and model-based risk estimates show that with current safety measures, the risk of transmission of known blood-borne pathogens to plasma product recipients is extremely low. However, because the residual risk of virus transmissions is also influenced by the incidence rate of infection in the donor population, it makes sense to control these incidence rates, as well. The current measures are aiming in the right direction, but integration of guidelines is required to adequately address their common goal: controlling the risk of infectious disease transmission by plasma-derived medicinal products. By integration of guidelines, the combination of various types of safety measures to prevent virus transmission-donor selection, donation screening, quarantining, and virus removal and/or inactivation during production-may be consistently interpreted and adequately assessed. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - Velthove, Karin J AU - Velthove KJ AD - Division of Plasma Products, Sanquin Blood Supply Foundation, Amsterdam, the Netherlands. k.velthove@sanquin.nl FAU - Over, Jan AU - Over J FAU - Abbink, Kristiena AU - Abbink K FAU - Janssen, Mart P AU - Janssen MP LA - eng PT - Journal Article PL - United States TA - Transfus Med Rev JT - Transfusion medicine reviews JID - 8709027 SB - IM MH - Blood Component Transfusion/adverse effects/legislation & jurisprudence/*standards MH - Blood Donors/*legislation & jurisprudence MH - Blood Safety/*methods MH - *Blood-Borne Pathogens MH - Donor Selection/*legislation & jurisprudence MH - Europe MH - HIV Infections/transmission MH - Hepatitis B/transmission MH - Hepatitis C/transmission MH - Humans MH - Patient Safety MH - Plasma/*virology MH - Risk EDAT- 2013/07/28 06:00 MHDA- 2014/02/25 06:00 CRDT- 2013/07/27 06:00 PHST- 2013/02/19 00:00 [received] PHST- 2013/05/23 00:00 [revised] PHST- 2013/05/24 00:00 [accepted] PHST- 2013/07/27 06:00 [entrez] PHST- 2013/07/28 06:00 [pubmed] PHST- 2014/02/25 06:00 [medline] AID - S0887-7963(13)00035-7 [pii] AID - 10.1016/j.tmrv.2013.05.002 [doi] PST - ppublish SO - Transfus Med Rev. 2013 Jul;27(3):179-83. doi: 10.1016/j.tmrv.2013.05.002. PMID- 34153132 OWN - NLM STAT- MEDLINE DCOM- 20210909 LR - 20210909 IS - 1469-8137 (Electronic) IS - 0028-646X (Linking) VI - 232 IP - 1 DP - 2021 Oct TI - Towards a statistically robust determination of minimum water potential and hydraulic risk in plants. PG - 404-417 LID - 10.1111/nph.17571 [doi] AB - Minimum water potential (Ψ(min) ) is a key variable for characterizing dehydration tolerance and hydraulic safety margins (HSMs) in plants. Ψ(min) is usually estimated as the absolute minimum tissue Ψ experienced by a species, but this is problematic because sample extremes are affected by sample size and the underlying probability distribution. We compare alternative approaches to estimate Ψ(min) and assess the corresponding uncertainties and biases; propose statistically robust estimation methods based on extreme value theory (EVT); and assess the implications of our results for the characterization of hydraulic risk. Our results show that current estimates of Ψ(min) and HSMs are biased, as they are strongly affected by sample size. Because sampling effort is generally higher for species living in dry environments, the differences in current Ψ(min) estimates between these species and those living under milder conditions are partly artefactual. When this bias is corrected using EVT methods, resulting HSMs tend to increase substantially with resistance to embolism across species. Although data availability and representativeness remain the main challenges for proper determination of Ψ(min) , a closer look at Ψ distributions and the use of statistically robust methods to estimate Ψ(min) opens new ground for characterizing plant hydraulic risks. CI - © 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. FAU - Martínez-Vilalta, Jordi AU - Martínez-Vilalta J AUID- ORCID: 0000-0002-2332-7298 AD - CREAF, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. AD - Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. FAU - Santiago, Louis S AU - Santiago LS AUID- ORCID: 0000-0001-5994-6122 AD - Department of Botany & Plant Sciences, University of California, 2150 Batchelor Hall, Riverside, CA, 92521, USA. FAU - Poyatos, Rafael AU - Poyatos R AUID- ORCID: 0000-0003-0521-2523 AD - CREAF, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. AD - Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. FAU - Badiella, Llorenç AU - Badiella L AUID- ORCID: 0000-0002-9653-7421 AD - Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. FAU - de Cáceres, Miquel AU - de Cáceres M AUID- ORCID: 0000-0001-7132-2080 AD - CREAF, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. AD - Joint Research Unit CTFC - AGROTECNIO, Solsona, 25280, Spain. FAU - Aranda, Ismael AU - Aranda I AUID- ORCID: 0000-0001-9086-7940 AD - Centro de Investigación Forestal, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Carretera Coruña Km 7.5, Madrid, E-28040, Spain. FAU - Delzon, Sylvain AU - Delzon S AUID- ORCID: 0000-0003-3442-1711 AD - INRAE, BIOGECO, Univ. Bordeaux, Pessac, 33615, France. FAU - Vilagrosa, Alberto AU - Vilagrosa A AUID- ORCID: 0000-0002-1432-1214 AD - CEAM Foundation, Joint Research Unit University of Alicante-CEAM, Dept Ecology, University of Alicante, Carr. de San Vicente del Raspeig, PO Box 99, Alicante, 03080, Spain. FAU - Mencuccini, Maurizio AU - Mencuccini M AUID- ORCID: 0000-0003-0840-1477 AD - CREAF, Bellaterra (Cerdanyola del Vallès), Catalonia, E08193, Spain. AD - ICREA, Pg. Lluís Companys 23, Barcelona, 08010, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210716 PL - England TA - New Phytol JT - The New phytologist JID - 9882884 RN - 059QF0KO0R (Water) SB - IM MH - Plant Leaves MH - *Water MH - *Xylem OTO - NOTNLM OT - drought resistance OT - drought tolerance OT - extreme values OT - hydraulic risk OT - hydraulic safety margin OT - minimum water potential OT - physiological limits EDAT- 2021/06/22 06:00 MHDA- 2021/09/10 06:00 CRDT- 2021/06/21 17:30 PHST- 2021/01/08 00:00 [received] PHST- 2021/06/14 00:00 [accepted] PHST- 2021/06/22 06:00 [pubmed] PHST- 2021/09/10 06:00 [medline] PHST- 2021/06/21 17:30 [entrez] AID - 10.1111/nph.17571 [doi] PST - ppublish SO - New Phytol. 2021 Oct;232(1):404-417. doi: 10.1111/nph.17571. Epub 2021 Jul 16. PMID- 36433553 OWN - NLM STAT- MEDLINE DCOM- 20221129 LR - 20221213 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 22 IP - 22 DP - 2022 Nov 19 TI - Classification Framework of the Bearing Faults of an Induction Motor Using Wavelet Scattering Transform-Based Features. LID - 10.3390/s22228958 [doi] LID - 8958 AB - In the machine learning and data science pipelines, feature extraction is considered the most crucial component according to researchers, where generating a discriminative feature matrix is the utmost challenging task to achieve high classification accuracy. Generally, the classical feature extraction techniques are sensitive to the noisy component of the signal and need more time for training. To deal with these issues, a comparatively new feature extraction technique, referred to as a wavelet scattering transform (WST) is utilized, and incorporated with ML classifiers to design a framework for bearing fault classification in this paper. The WST is a knowledge-based technique, and the structure is similar to the convolution neural network. This technique provides low-variance features of real-valued signals, which are usually necessary for classification tasks. These signals are resistant to signal deformation and preserve information at high frequencies. The current signal data from a publicly available dataset for three different bearing conditions are considered. By combining the scattering path coefficients, the decomposition coefficients from the 0th and 1st layers are considered as features. The experimental results demonstrate that WST-based features, when used with ensemble ML algorithms, could achieve more than 99% classification accuracy. The performance of ANN models with these features is similar. This work exhibits that utilizing WST coefficients for the motor current signal as features can improve the bearing fault classification accuracy when compared to other feature extraction approaches such as empirical wavelet transform (EWT), information fusion (IF), and wavelet packet decomposition (WPD). Thus, our proposed approach can be considered as an effective classification method for the fault diagnosis of rotating machinery. FAU - Toma, Rafia Nishat AU - Toma RN AD - Department of Electrical, Electronics and Computer Engineering, University of Ulsan, Ulsan 44610, Republic of Korea. FAU - Gao, Yangde AU - Gao Y AD - Department of Electrical, Electronics and Computer Engineering, University of Ulsan, Ulsan 44610, Republic of Korea. FAU - Piltan, Farzin AU - Piltan F AUID- ORCID: 0000-0002-8420-9500 AD - Department of Electrical, Electronics and Computer Engineering, University of Ulsan, Ulsan 44610, Republic of Korea. FAU - Im, Kichang AU - Im K AD - ICT Convergence Safety Research Center, University of Ulsan, Ulsan 44610, Republic of Korea. FAU - Shon, Dongkoo AU - Shon D AD - Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of Korea. FAU - Yoon, Tae Hyun AU - Yoon TH AD - Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of Korea. FAU - Yoo, Dae-Seung AU - Yoo DS AD - Electronics and Telecommunications Research Institute (ETRI), Daejeon 34129, Republic of Korea. FAU - Kim, Jong-Myon AU - Kim JM AUID- ORCID: 0000-0002-5185-1062 AD - Department of Electrical, Electronics and Computer Engineering, University of Ulsan, Ulsan 44610, Republic of Korea. AD - PD Technologies Cooperation, Ulsan 44610, Republic of Korea. LA - eng GR - RS-2022-00142509/Ministry of Trade, Industry and Energy/ PT - Journal Article DEP - 20221119 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Wavelet Analysis MH - *Neural Networks, Computer MH - Machine Learning MH - Algorithms PMC - PMC9696953 OTO - NOTNLM OT - artificial neural network OT - bearing fault diagnosis OT - condition monitoring OT - extreme gradient boosting OT - induction motor OT - motor current signal OT - random forest OT - wavelet scattering transform COIS- The authors declare no conflict of interest. EDAT- 2022/11/27 06:00 MHDA- 2022/11/30 06:00 PMCR- 2022/11/19 CRDT- 2022/11/26 01:37 PHST- 2022/09/29 00:00 [received] PHST- 2022/11/08 00:00 [revised] PHST- 2022/11/16 00:00 [accepted] PHST- 2022/11/26 01:37 [entrez] PHST- 2022/11/27 06:00 [pubmed] PHST- 2022/11/30 06:00 [medline] PHST- 2022/11/19 00:00 [pmc-release] AID - s22228958 [pii] AID - sensors-22-08958 [pii] AID - 10.3390/s22228958 [doi] PST - epublish SO - Sensors (Basel). 2022 Nov 19;22(22):8958. doi: 10.3390/s22228958. PMID- 30398128 OWN - NLM STAT- MEDLINE DCOM- 20200330 LR - 20200330 IS - 1938-744X (Electronic) IS - 1935-7893 (Print) IS - 1935-7893 (Linking) VI - 13 IP - 3 DP - 2019 Jun TI - Environmental Heat Exposure and Heat-Related Symptoms in United States Coast Guard Deepwater Horizon Disaster Responders. PG - 561-569 LID - 10.1017/dmp.2018.120 [doi] AB - OBJECTIVES: The response to the 2010 Deepwater Horizon oil spill was impacted by heat. We evaluated the association between environmental heat exposure and self-reported heat-related symptoms in US Coast Guard Deepwater Horizon disaster responders. METHODS: Utilizing climate data and postdeployment survey responses from 3648 responders, we assigned heat exposure categories based on both wet bulb globe temperature (WBGT) and heat index (HI) measurements (median, mean, maximum). We calculated prevalence ratios (PRs) and 95% confidence intervals (CIs) via adjusted Poisson regression models with robust error variance to estimate associations with reported heat-related symptoms. We also evaluated the association between use of personal protective equipment (PPE) and heat-related symptoms. RESULTS: Those in the highest WBGT median-based heat exposure category had increased prevalence of heat-related symptoms compared to those in the lowest category (PR=2.22 [95% CI: 1.61, 3.06]), and there was a significant exposure-response trend (P<.001). Results were similar for exposure categories based on WBGT and HI metrics. Analyses stratified by use of PPE found significantly stronger associations between environmental heat exposure and heat-related symptoms in those who did not use PPE (PR=2.23 [95% CI: 1.10, 4.51]) than in those who did (PR=1.64 [95% CI: 1.14, 2.36]). CONCLUSIONS: US Coast Guard Deepwater Horizon disaster responders who experienced higher levels of environmental heat had higher prevalences of heat-related symptoms. These symptoms may impact health, safety, and mission effectiveness. As global climate change increases the frequency of disasters and weather extremes, actions must be taken to prevent heat-related health impacts among disaster responders. (Disaster Med Public Health Preparedness. 2019;13:561-569). FAU - Erickson, Elizabeth A AU - Erickson EA AD - 1Department of Preventive Medicine and Biostatistics,F. Edward Hebert School of Medicine,Uniformed Services University of the Health Sciences,Bethesda,Maryland. FAU - Engel, Lawrence S AU - Engel LS AD - 2Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina,Chapel Hill,North Carolina. FAU - Christenbury, Kate AU - Christenbury K AD - 3Social & Scientific Systems,Durham,North Carolina. FAU - Weems, Laura AU - Weems L AD - 4; Safety and Occupational Health Office,United StatesArmy Corps of Engineers,Little Rock,Arkansas. FAU - Schwartz, Erica G AU - Schwartz EG AD - 5Directorate of Health,Safety and Work Life,United StatesCoast Guard,Washington, DC. FAU - Rusiecki, Jennifer A AU - Rusiecki JA AD - 1Department of Preventive Medicine and Biostatistics,F. Edward Hebert School of Medicine,Uniformed Services University of the Health Sciences,Bethesda,Maryland. LA - eng GR - P30 ES010126/ES/NIEHS NIH HHS/United States GR - R01 ES020874/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20181106 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Adult MH - Chi-Square Distribution MH - Emergency Responders/*statistics & numerical data MH - Environmental Exposure/adverse effects MH - Female MH - Gulf of Mexico MH - Hot Temperature/*adverse effects MH - Humans MH - Male MH - Middle Aged MH - Military Personnel/*statistics & numerical data MH - Petroleum Pollution/statistics & numerical data MH - Poisson Distribution MH - Syndrome PMC - PMC6762031 MID - NIHMS1507790 OTO - NOTNLM OT - Deepwater Horizon OT - disaster response OT - heat exposure OT - heat illness OT - oil spill response EDAT- 2018/11/07 06:00 MHDA- 2020/03/31 06:00 PMCR- 2019/12/01 CRDT- 2018/11/07 06:00 PHST- 2018/11/07 06:00 [pubmed] PHST- 2020/03/31 06:00 [medline] PHST- 2018/11/07 06:00 [entrez] PHST- 2019/12/01 00:00 [pmc-release] AID - S1935789318001209 [pii] AID - 10.1017/dmp.2018.120 [doi] PST - ppublish SO - Disaster Med Public Health Prep. 2019 Jun;13(3):561-569. doi: 10.1017/dmp.2018.120. Epub 2018 Nov 6. PMID- 24048678 OWN - NLM STAT- MEDLINE DCOM- 20140929 LR - 20211021 IS - 0975-0711 (Electronic) IS - 0254-8860 (Linking) VI - 33 IP - 1 DP - 2014 Jan TI - Liver biopsy for parenchymal liver disease - is routine real time image guidance unnecessary? PG - 50-4 LID - 10.1007/s12664-013-0393-3 [doi] AB - Liver biopsy even today remains the standard of care for grading and staging chronic hepatitis despite advances in noninvasive markers of liver fibrosis. Literature suggests an expanding role for real-time image guided liver biopsy and declining trend for blind liver biopsies. In our center, where we perform around 400 liver biopsies per year, we performed a prospective clinical audit of our practice of blind outpatient percutaneous liver biopsies. Patients requiring histological grading and staging of chronic hepatitis routinely undergo blind outpatient percutaneous liver biopsies in our endoscopy unit unless there is a definite indication for real-time image guidance. All procedures were assessed for safety, and all specimens were evaluated by a specimen quality grading score for adequacy for grading and staging of chronic hepatitis. Of the 446 patients referred for histological grading and staging of chronic hepatitis C by liver biopsy, only 42 patients (9.5 %) required real-time ultrasound for liver biopsy. The remaining 404 patients underwent blind outpatient percutaneous liver biopsies which were found to be extremely safe with no major complications, yielding adequate liver tissue with high specimen quality score allowing optimal grading and staging of chronic hepatitis. FAU - John, Anil AU - John A AD - Department of Gastroenterology, Hamad Medical Corporation, Doha, Qatar, aniljohn44@gmail.com. FAU - Al Kaabi, Saad AU - Al Kaabi S FAU - Soofi, Madiha Emran AU - Soofi ME FAU - Mohannadi, Muneera AU - Mohannadi M FAU - Kandath, Salva Manam AU - Kandath SM FAU - Derbala, Moataz AU - Derbala M FAU - Yakoub, Rafie AU - Yakoub R FAU - Al-Ahdal, Esra Mohammed AU - Al-Ahdal EM FAU - Sharma, Manik AU - Sharma M FAU - Wani, Hamid AU - Wani H FAU - Dweik, Nazeeh AU - Dweik N FAU - John, Anjum AU - John A FAU - Butt, Mohammed Tariq AU - Butt MT LA - eng PT - Journal Article DEP - 20130919 PL - India TA - Indian J Gastroenterol JT - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JID - 8409436 SB - IM MH - Adult MH - Female MH - Hepatitis C, Chronic/pathology MH - Hepatitis, Chronic/*pathology MH - Humans MH - Image-Guided Biopsy/*methods/statistics & numerical data MH - Liver/*pathology MH - Male MH - Middle Aged MH - Prospective Studies MH - Safety MH - Severity of Illness Index EDAT- 2013/09/21 06:00 MHDA- 2014/09/30 06:00 CRDT- 2013/09/20 06:00 PHST- 2013/05/18 00:00 [received] PHST- 2013/08/20 00:00 [accepted] PHST- 2013/09/20 06:00 [entrez] PHST- 2013/09/21 06:00 [pubmed] PHST- 2014/09/30 06:00 [medline] AID - 10.1007/s12664-013-0393-3 [doi] PST - ppublish SO - Indian J Gastroenterol. 2014 Jan;33(1):50-4. doi: 10.1007/s12664-013-0393-3. Epub 2013 Sep 19. PMID- 17419077 OWN - NLM STAT- MEDLINE DCOM- 20070816 LR - 20070611 IS - 1078-5884 (Print) IS - 1078-5884 (Linking) VI - 34 IP - 1 DP - 2007 Jul TI - Experimental study of a novel suture-less aortic anastomotic device. PG - 79-86 AB - OBJECTIVES: To assess the suitability and safety of a novel suture-less hermetic docking head (HDH) device for aortic anastomosis, and to test it in vitro, on cadavers, and in animals. DESIGN: Uncontrolled prospective studies. MATERIALS: HDH device with commercial vascular grafts. METHODS: Two experimental series were conducted in vitro to test the hermetic seal of the anastomosis and the fixation of the device. Another series was performed in 6 cadavers with atherosclerotic aortas. Two in vivo trials tested the HDH device when implanted in ten and five pigs, respectively, with follow-up of 22 weeks. Pathological, histological and radiographic studies of the aorta were performed. RESULTS: The in vitro and cadaveric studies demonstrated the resilience of the device under physiological and extreme conditions (up to 1200mmHg pulsatile flow on the bench and up to 270mmHg in cadaveric studies). These studies also established the safety and ease of application of the device in both normal and atherosclerotic aortas. Insertion was easy and rapid. There was no indication of leakage, narrowing or stenosis at the anastomotic sites. The implants' position was maintained without distal or proximal migration. Reliable fixation was observed despite significant increase (up to 112%) in the weight of the animals. Histologically, normal tissue reaction of the lamina was observed. CONCLUSIONS: The suture-less HDH device's behavior in vitro and in vivo suggests that this implant is useful for aortic anastomosis, and its use is faster and simpler than common suturing techniques. FAU - Yoffe, B AU - Yoffe B AD - Department of General and Vascular Surgery, Barzilai Medical Center, Ashkelon, Israel. sarel@barzi.health.gov.il FAU - Vaysbeyn, I AU - Vaysbeyn I FAU - Urin, Y AU - Urin Y FAU - Waysbeyn, I AU - Waysbeyn I FAU - Zubkova, O AU - Zubkova O FAU - Chernyavskiy, V AU - Chernyavskiy V FAU - Ben-Dor, D AU - Ben-Dor D LA - eng PT - Journal Article DEP - 20070406 PL - England TA - Eur J Vasc Endovasc Surg JT - European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery JID - 9512728 SB - IM MH - Animals MH - Aortic Aneurysm, Abdominal/*surgery MH - Aortic Aneurysm, Thoracic/*surgery MH - Blood Vessel Prosthesis Implantation/*methods MH - Cadaver MH - Disease Models, Animal MH - Equipment Design MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Prospective Studies MH - Suture Techniques/*instrumentation MH - Swine EDAT- 2007/04/10 09:00 MHDA- 2007/08/19 09:00 CRDT- 2007/04/10 09:00 PHST- 2006/12/06 00:00 [received] PHST- 2007/02/02 00:00 [accepted] PHST- 2007/04/10 09:00 [pubmed] PHST- 2007/08/19 09:00 [medline] PHST- 2007/04/10 09:00 [entrez] AID - S1078-5884(07)00132-3 [pii] AID - 10.1016/j.ejvs.2007.02.004 [doi] PST - ppublish SO - Eur J Vasc Endovasc Surg. 2007 Jul;34(1):79-86. doi: 10.1016/j.ejvs.2007.02.004. Epub 2007 Apr 6. PMID- 28303772 OWN - NLM STAT- MEDLINE DCOM- 20180710 LR - 20230209 IS - 1938-744X (Electronic) IS - 1935-7893 (Print) IS - 1935-7893 (Linking) VI - 11 IP - 5 DP - 2017 Oct TI - Physiological Evaluation of Cooling Devices in Conjunction With Personal Protective Ensembles Recommended for Use in West Africa. PG - 573-579 LID - 10.1017/dmp.2016.209 [doi] AB - OBJECTIVE: Cooling devices (CDs) worn under personal protective equipment (PPE) can alleviate some of the heat stress faced by health care workers responding to the Ebola outbreak in West Africa. METHODS: Six healthy, young individuals were tested while wearing 4 different CDs or no cooling (control) under PPE in an environmental chamber (32°C/92% relative humidity) while walking (3 METs, 2.5 mph, 0% grade) on a treadmill for 60 minutes. Exercise was preceded by a 15-minute stabilization period and a 15-minute donning period. RESULTS: The control condition resulted in a significantly higher rectal temperature (Tre) at the end of the exercise than did all CD conditions (CD1, P=0.004; CD2, P=0.01; CD3, P=0.000; CD4, P=0.000) with CD1 and CD2 resulting in a higher Tre than CD3 and CD4 (P<0.05). The control condition resulted in a higher heart rate (HR) at the end of exercise than did the CD3 (P=0.01) and CD4 (P=0.009) conditions, whereas the HR of the CD1 and CD2 conditions was higher than that of the CD3 and CD4 conditions (P<0.05). Weight loss in the control condition was higher than in the CD3 (P=0.003) and CD4 (P=0.01) conditions. Significant differences in subjective measurements of thermal stress were found across conditions and time. CONCLUSIONS: Use of CDs can be advantageous in decreasing the negative physiological and subjective responses to the heat stress encountered by health care workers wearing PPE in hot and humid environments. (Disaster Med Public Health Preparedness. 2017;11:573-579). FAU - Quinn, Tyler AU - Quinn T AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Kim, Jung-Hyun AU - Kim JH AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Strauch, Amanda AU - Strauch A AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Wu, Tianzhou AU - Wu T AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Powell, Jeffery AU - Powell J AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Roberge, Raymond AU - Roberge R AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Shaffer, Ronald AU - Shaffer R AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. FAU - Coca, Aitor AU - Coca A AD - National Personal Protective Technology Laboratory of the National Institute for Occupational Safety and Health,Pittsburgh,Pennsylvania. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States PT - Journal Article DEP - 20170317 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Africa, Western MH - Analysis of Variance MH - Cryotherapy/*methods/*standards MH - Disaster Planning/methods/trends MH - Environmental Exposure/adverse effects MH - Heat Stress Disorders/etiology/therapy MH - Hot Temperature/adverse effects MH - Humans MH - Personal Protective Equipment/*adverse effects/*standards MH - Surveys and Questionnaires PMC - PMC9903158 MID - NIHMS1867833 OTO - NOTNLM OT - disease outbreaks OT - emergency medicine OT - emergency preparedness OT - environmental exposure OT - extreme heat EDAT- 2017/03/18 06:00 MHDA- 2018/07/11 06:00 PMCR- 2023/02/07 CRDT- 2017/03/18 06:00 PHST- 2017/03/18 06:00 [pubmed] PHST- 2018/07/11 06:00 [medline] PHST- 2017/03/18 06:00 [entrez] PHST- 2023/02/07 00:00 [pmc-release] AID - S1935789316002093 [pii] AID - 10.1017/dmp.2016.209 [doi] PST - ppublish SO - Disaster Med Public Health Prep. 2017 Oct;11(5):573-579. doi: 10.1017/dmp.2016.209. Epub 2017 Mar 17. PMID- 32341185 OWN - NLM STAT- MEDLINE DCOM- 20210917 LR - 20210917 IS - 1473-4257 (Electronic) IS - 0306-6800 (Linking) VI - 46 IP - 11 DP - 2020 Nov TI - Three scenarios illustrating ethical concerns when considering bariatric surgery in obese adolescents with Prader-Willi syndrome. PG - 738-742 LID - 10.1136/medethics-2019-106038 [doi] AB - Prader-Willi syndrome (PWS) is one of the 25 syndromic forms of obesity, in which patients present-in addition to different degrees of obesity-intellectual disability, endocrine disturbs, hyperphagia and/or other signs of hypothalamic dysfunction. In front of a severe/extreme obesity and the failure of non-invasive treatments, bariatric surgery is proposed as a therapeutic option. The complexity of the clinical condition, which could affect the long-term effects of bariatric surgery, and the frequent association with a mild to severe intellectual disability raise some ethical concerns in the treatment of obese PWS adolescents. This article analyses these issues referring to the principles of healthcare ethics: beneficence/non-maleficence (proportionality of treatments; minimisation of risks); respect of autonomy; justice. Based on these principles, three hypothetical scenarios are defined: (1) obese PWS adolescent, capable of making an autonomous decision; (2) obese PWS adolescent with a severe intellectual disability, whose parents agree with bariatric surgery; (3) obese PWS adolescent with a life-threatening condition and a severe intellectual disability, whose parents do not agree with bariatric surgery. The currently available evidence on efficacy and safety of bariatric surgery in PWS adolescents with extreme or severe obesity and the lack of adequate long-term follow-up suggests great caution even in a very life-threatening condition. Clinicians must always obtain a full IQ assessment of patients by psychologists. A multidisciplinary team is needed to analyse the clinical, psychological, social and ethical aspects and organise support for patient and parents, involving also the hospital ethical committee or, if necessary, legal authorities. CI - © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Di Pietro, Maria Luisa AU - Di Pietro ML AD - Sezione di Igiene, Dipartimento Universitario di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy. FAU - Zaçe, Drieda AU - Zaçe D AD - Sezione di Igiene, Dipartimento Universitario di Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, Rome, Italy drieda.zace@unicatt.it. LA - eng PT - Journal Article DEP - 20200427 PL - England TA - J Med Ethics JT - Journal of medical ethics JID - 7513619 SB - IM MH - Adolescent MH - *Bariatric Surgery MH - Beneficence MH - Humans MH - Hyperphagia MH - *Pediatric Obesity/complications MH - *Prader-Willi Syndrome/complications OTO - NOTNLM OT - autonomy OT - clinical ethics OT - minors/parental consent OT - surgery COIS- Competing interests: None declared. EDAT- 2020/04/29 06:00 MHDA- 2021/09/18 06:00 CRDT- 2020/04/29 06:00 PHST- 2019/12/17 00:00 [received] PHST- 2020/03/31 00:00 [revised] PHST- 2020/04/07 00:00 [accepted] PHST- 2020/04/29 06:00 [pubmed] PHST- 2021/09/18 06:00 [medline] PHST- 2020/04/29 06:00 [entrez] AID - medethics-2019-106038 [pii] AID - 10.1136/medethics-2019-106038 [doi] PST - ppublish SO - J Med Ethics. 2020 Nov;46(11):738-742. doi: 10.1136/medethics-2019-106038. Epub 2020 Apr 27. PMID- 26420268 OWN - NLM STAT- MEDLINE DCOM- 20160613 LR - 20181113 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 8 DP - 2015 Sep 29 TI - Primary malignant mucosal melanoma of the upper lip: a case report and review of the literature. PG - 499 LID - 10.1186/s13104-015-1459-3 [doi] LID - 499 AB - BACKGROUND: Malignant melanoma of oral cavity is a rare condition, accounting for 0.5% of all oral malignancies and about 1-2% of all melanomas. Oral melanomas have extremely poor prognosis with 5 years survival rate of 12.3%. The poor prognosis compared to cutaneous melanoma may be attributed to delay in reporting by patient and diagnosis, and apt to become ulcerated due to repeated trauma. The 'chameleonic' presentation of a mainly asymptomatic condition, the rarity of these lesions, the poor prognosis and the necessity of a highly specialized treatment are factors that should be seriously considered by the involved health provider. CASE PRESENTATION: We present a case of 32 years old male of Han ethnicity with mucosal melanoma of upper lip, comparing his clinical presentation and histological findings at his first visit and following the recurrence. The patient complained of black discoloration on the left side of upper lip since 4 years which gradually increased in size and later involved the skin of the lip. Excision with 5 mm safety margin was performed but the patient presented with the similar lesion after three and half years of the treatment. So, again wide excision with 2 cm safety margin was performed followed by reconstruction of the lip. CONCLUSION: This case provides an example of aggressive behavior of mucosal melanoma and emphasizes on the fact that any pigmented lesion detected in the oral cavity may exhibit potential growth and should be submitted to biopsy to exclude malignancy. It also exemplifies of how the time of diagnosis and the evolution of a disease could be seriously influenced by patient's behavior. FAU - Lamichhane, Narayan Sharma AU - Lamichhane NS AD - Department of Oral and Maxillofacial Surgery, Norman Bethune Hospital of Stomatology, Jilin University, Qinghua Road, Changchun, 130021, Jilin, People's Republic of China. narayansharma5oo@yahoo.com. AD - Department of Oral and Maxillofacial Surgery, School of Stomatology, Jiamusi University, Xuefu Street, Jiamusi, 15400, Heilongjiang, China. narayansharma5oo@yahoo.com. FAU - An, Jiping AU - An J AD - Department of Oral and Maxillofacial Surgery, Norman Bethune Hospital of Stomatology, Jilin University, Qinghua Road, Changchun, 130021, Jilin, People's Republic of China. 1792717355@qq.com. FAU - Liu, Qilin AU - Liu Q AD - Department of Oral and Maxillofacial Surgery, Norman Bethune Hospital of Stomatology, Jilin University, Qinghua Road, Changchun, 130021, Jilin, People's Republic of China. strurrancy@163.com. FAU - Zhang, Wei AU - Zhang W AD - Department of Oral and Maxillofacial Surgery, Norman Bethune Hospital of Stomatology, Jilin University, Qinghua Road, Changchun, 130021, Jilin, People's Republic of China. wangxr135@hotmail.com. LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20150929 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Adult MH - Humans MH - Lip Neoplasms/*pathology MH - Male MH - Melanoma/*pathology MH - Mouth Mucosa/*pathology MH - Neoplasm Recurrence, Local/pathology PMC - PMC4589098 EDAT- 2015/10/01 06:00 MHDA- 2016/06/14 06:00 PMCR- 2015/09/29 CRDT- 2015/10/01 06:00 PHST- 2015/02/20 00:00 [received] PHST- 2015/09/18 00:00 [accepted] PHST- 2015/10/01 06:00 [entrez] PHST- 2015/10/01 06:00 [pubmed] PHST- 2016/06/14 06:00 [medline] PHST- 2015/09/29 00:00 [pmc-release] AID - 10.1186/s13104-015-1459-3 [pii] AID - 1459 [pii] AID - 10.1186/s13104-015-1459-3 [doi] PST - epublish SO - BMC Res Notes. 2015 Sep 29;8:499. doi: 10.1186/s13104-015-1459-3. PMID- 7949470 OWN - NLM STAT- MEDLINE DCOM- 19941202 LR - 20180216 IS - 1018-8665 (Print) IS - 1018-8665 (Linking) VI - 189 IP - 3 DP - 1994 TI - Has mildness replaced cleanliness next to godliness? PG - 217-21 AB - Over the past 30 years we have witnessed a change in our approach to soaps. The turning point was, in fact, the publication of an article by Frosch and Kligman in 1979, in which they described a new method for assessing the irritancy of soaps. They maintained that the chief weakness of the usage tests in the past was that the reactions under normal usage conditions were weak and did not discriminate adequately between different soaps. They proposed a test, called the soap chamber test, which was conducted under extreme conditions, on people known to have a sensitive skin, thereby resulting in strong reactions that emphasized the slight differences between the various soaps. Frosch and Kligman's work opened up a whole new era in the field of assessment of soap quality. Following their initial studies, many other studies were conducted, including the exaggerated use tests, often in conjunction with instrumental methods of evaluation, such as measurement of transepidermal water loss, electrical conductance, skin color and blood flow, and other tests designed to evaluate the irritation potential of various soaps. All those tests had a common purpose: to achieve extreme conditions which would provide greater sensitivity and discriminating power and would accentuate and emphasize the differences between soaps as much as possible: the greater the discrimination and the differences between the products, the more efficient and useful the test. The introduction and publication of tests such as those completely changed out approach to soaps. The sought-after qualities in a soap became safety, mildness, gentleness, less irritation, less drying--in particular, gentleness and mildness were emphasized.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Wolf, R AU - Wolf R AD - Department of Dermatology, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel. LA - eng PT - Journal Article PL - Switzerland TA - Dermatology JT - Dermatology (Basel, Switzerland) JID - 9203244 RN - 0 (Soaps) SB - IM MH - Dermatitis, Irritant/diagnosis/etiology MH - Humans MH - *Hygiene MH - *Soaps/adverse effects EDAT- 1994/01/01 00:00 MHDA- 1994/01/01 00:01 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 1994/01/01 00:01 [medline] PHST- 1994/01/01 00:00 [entrez] AID - 10.1159/000246841 [doi] PST - ppublish SO - Dermatology. 1994;189(3):217-21. doi: 10.1159/000246841. PMID- 19396071 OWN - NLM STAT- MEDLINE DCOM- 20090707 LR - 20191210 IS - 1930-7381 (Print) IS - 1930-7381 (Linking) VI - 17 IP - 5 DP - 2009 May TI - An update on best practice guidelines for specialized facilities and resources necessary for weight loss surgical programs. PG - 911-7 LID - 10.1038/oby.2008.581 [doi] AB - The objective of this study is to update evidence-based best practice guidelines for specialized facilities and resources for weight loss surgery (WLS). We performed systematic search of English-language literature on WLS and facilities, equipment, and resources published between April 2004 and May 2007 in PubMed, MEDLINE, and the Cochrane Library. Keywords were used to narrow the search for a selective review of abstracts, retrieval of full articles, and grading of evidence according to systems used in established evidence-based models. Evidence-based best practice recommendations from the most recent literature on specialized facilities and resources for WLS were developed. We identified 1,647 papers in our literature search; the 46 most relevant were reviewed in detail. Regular updates of evidence-based recommendations for best practices in facilities and resources for WLS are required to address technology advances and growing recognition of the need for adequate equipment and specially built nursing units. Key factors in patient safety include availability of trained personnel and specialized equipment for the care of extremely obese WLS patients. FAU - Lautz, David B AU - Lautz DB AD - Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA. dlautz@partners.org FAU - Jiser, Michael E AU - Jiser ME FAU - Kelly, John J AU - Kelly JJ FAU - Shikora, Scott A AU - Shikora SA FAU - Partridge, Sheila K AU - Partridge SK FAU - Romanelli, John R AU - Romanelli JR FAU - Cella, Robert J AU - Cella RJ FAU - Ryan, John P AU - Ryan JP LA - eng GR - P30-DK-46200/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20090219 PL - United States TA - Obesity (Silver Spring) JT - Obesity (Silver Spring, Md.) JID - 101264860 SB - IM MH - Bariatric Surgery/*standards MH - Centers for Disease Control and Prevention, U.S. MH - Humans MH - Magnetic Resonance Imaging MH - Obesity/diagnostic imaging/*epidemiology/pathology/*surgery MH - Obesity, Morbid/diagnostic imaging/epidemiology/pathology/surgery MH - Patient Care Team/standards MH - *Practice Guidelines as Topic MH - Safety MH - Tomography, X-Ray Computed MH - Treatment Outcome MH - United States/epidemiology MH - Weight Loss RF - 24 EDAT- 2009/04/28 09:00 MHDA- 2009/07/08 09:00 CRDT- 2009/04/28 09:00 PHST- 2009/04/28 09:00 [entrez] PHST- 2009/04/28 09:00 [pubmed] PHST- 2009/07/08 09:00 [medline] AID - oby2008581 [pii] AID - 10.1038/oby.2008.581 [doi] PST - ppublish SO - Obesity (Silver Spring). 2009 May;17(5):911-7. doi: 10.1038/oby.2008.581. Epub 2009 Feb 19. PMID- 32920544 OWN - NLM STAT- MEDLINE DCOM- 20201120 LR - 20210727 IS - 1865-7125 (Electronic) IS - 0341-0382 (Linking) VI - 75 IP - 11-12 DP - 2020 Nov 26 TI - Dynamic analysis of the mathematical model of COVID-19 with demographic effects. PG - 389-396 LID - 10.1515/znc-2020-0121 [doi] AB - The coronavirus is currently extremely contagious for humankind, which is a zoonotic tropical disease. The pandemic is the largest in history, affecting almost the whole world. What makes the condition the worst of all is no specific effective treatment available. In this article, we present an extended and modified form of SIR and SEIR model, respectively. We begin by investigating a simple mathematical model that describes the pandemic. Then we apply different safety measures to control the pandemic situation. The mathematical model with and without control is solved by using homotopy perturbation method. Obtained solutions have been presented graphically. Finally, we develop another mathematical model, including quarantine and hospitalization. FAU - Faraz, Naeem AU - Faraz N AD - International Cultural Exchange School, Donghua University, West Yanan Road 1882, Shanghai 200051, PR China. FAU - Khan, Yasir AU - Khan Y AD - Department of Mathematics, University of Hafr Al-Batin, Hafr Al-Batin 31991, Saudi Arabia. FAU - Goufo, E F Doungmo AU - Goufo EFD AD - Department of Mathematical Sciences, University of South Africa, Florida, 0003, South Africa. FAU - Anjum, Amna AU - Anjum A AD - Jiangsu University, JiangsuPR China. FAU - Anjum, Ali AU - Anjum A AD - Department of Psychiatry, Services Hospital, Lahore, 54000, Pakistan. LA - eng PT - Journal Article PL - Germany TA - Z Naturforsch C J Biosci JT - Zeitschrift fur Naturforschung. C, Journal of biosciences JID - 8912155 SB - IM MH - COVID-19 MH - Coronavirus Infections/*epidemiology/prevention & control MH - Demography/*statistics & numerical data MH - Hospitalization/statistics & numerical data MH - Humans MH - *Models, Theoretical MH - Pandemics/prevention & control MH - Pneumonia, Viral/*epidemiology/prevention & control MH - Quarantine/statistics & numerical data OTO - NOTNLM OT - COVID-19 OT - homotopy method OT - mathematical model OT - mathematical model with and without control OT - pandemic EDAT- 2020/09/14 06:00 MHDA- 2020/11/21 06:00 CRDT- 2020/09/13 20:40 PHST- 2020/06/08 00:00 [received] PHST- 2020/08/22 00:00 [accepted] PHST- 2020/09/14 06:00 [pubmed] PHST- 2020/11/21 06:00 [medline] PHST- 2020/09/13 20:40 [entrez] AID - znc-2020-0121 [pii] AID - 10.1515/znc-2020-0121 [doi] PST - ppublish SO - Z Naturforsch C J Biosci. 2020 Nov 26;75(11-12):389-396. doi: 10.1515/znc-2020-0121. PMID- 19267122 OWN - NLM STAT- MEDLINE DCOM- 20090423 LR - 20131121 IS - 1077-3525 (Print) IS - 1077-3525 (Linking) VI - 15 IP - 1 DP - 2009 Jan-Mar TI - Cananea copper mine: An international effort to improve hazardous working conditions in Mexico. PG - 14-20 AB - A team of international occupational health and safety professionals evaluated the working conditions and health status of miners at a giant open-pit copper mine in Cananea, Mexico. Workers in the ore processing plants were exposed to levels of crystalline silica 10 times the Mexican regulatory limit, high levels of acid mist and noise, and numerous safety hazards, including unguarded machinery and malfunctioning 10- and 15-ton cranes. Lung function testing and interviews with physicians showed a substantial percentage of miners with adverse respiratory symptoms including shortness of breath (46%), wheezing (12%), coughing (12%), and elevated sputum production (10%). The mine owner, Grupo Mexico, violated Mexican law by failing to conduct an industrial hygiene survey sufficient to identify, evaluate, and control health hazards including exposure to mineral dust (including silica), acid mists, airborne solvents, high noise levels, high vibration levels, and extreme temperatures. FAU - Zubieta, Ingrid X AU - Zubieta IX AD - Labor Occupational Safety and Health Program, University of California, Los Angeles, CA, USA. ixzubieta@ucla.edu FAU - Brown, Garrett AU - Brown G FAU - Cohen, Robert AU - Cohen R FAU - Medina, Enrique AU - Medina E LA - eng PT - Journal Article PL - England TA - Int J Occup Environ Health JT - International journal of occupational and environmental health JID - 9505217 RN - 789U1901C5 (Copper) SB - IM MH - Adult MH - Copper MH - Humans MH - Mexico MH - Middle Aged MH - Mining/legislation & jurisprudence/*standards MH - Occupational Diseases/etiology/*prevention & control MH - Occupational Exposure/prevention & control MH - Respiratory Tract Diseases/prevention & control MH - Safety Management/legislation & jurisprudence/*methods EDAT- 2009/03/10 09:00 MHDA- 2009/04/25 09:00 CRDT- 2009/03/10 09:00 PHST- 2009/03/10 09:00 [entrez] PHST- 2009/03/10 09:00 [pubmed] PHST- 2009/04/25 09:00 [medline] AID - 10.1179/107735209799449789 [doi] PST - ppublish SO - Int J Occup Environ Health. 2009 Jan-Mar;15(1):14-20. doi: 10.1179/107735209799449789. PMID- 29292624 OWN - NLM STAT- MEDLINE DCOM- 20190611 LR - 20190613 IS - 1565-4753 (Print) IS - 1565-4753 (Linking) VI - 15 IP - 2 DP - 2017 Dec TI - Treatment of Girls and Boys with McCune-Albright Syndrome with Precocious Puberty - Update 2017. PG - 136-141 LID - 10.17458/per.vol15.2017.nau.treatmentgirlsboys [doi] AB - The most common endocrinopathy associated with McCune-Albright Syndrome (MAS) is peripheral precocious puberty (PP) which occurs far more often in girls than in boys. We will discuss the latest advancements in the treatment of precocious puberty in MAS that have been achieved during the past 10 years. However, due to the rarity of the condition and the heterogeneity of the disease, research in this field is limited particularly in regards to treatment in boys. In girls, a period of watchful waiting is recommended prior to initiating therapy due to extreme variability in the clinical course. This article will review in detail current pharmacologic treatment in girls, which typically consists of either inhibiting estrogen production or blocking estrogen action at the level of the end-organ. The two treatments with the most evidence at this time are Tamoxifen (which is an estrogen receptor modulator) and Letrozole (which is a 3rd generation aromatase inhibitor). This article will also review the current treatment strategies in boys which typically include using an androgen receptor blocker and an aromatase inhibitor. Due to the rarity of the condition, large multicenter collaborative studies are needed to further investigate efficacy and safety with the goal of establishing the gold standard for treatment of PP in children with MAS. CI - Copyright© of YS Medical Media ltd. FAU - Neyman, Anna AU - Neyman A AD - Department of Pediatrics, Section of Endocrinology/ Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, USA. FAU - Eugster, Erica A AU - Eugster EA AD - Department of Pediatrics, Section of Endocrinology/ Diabetology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, USA. LA - eng GR - T32 DK065549/DK/NIDDK NIH HHS/United States PT - Journal Article PL - Israel TA - Pediatr Endocrinol Rev JT - Pediatric endocrinology reviews : PER JID - 101202124 RN - 0 (Aromatase Inhibitors) RN - 7LKK855W8I (Letrozole) SB - IM MH - Aromatase Inhibitors MH - Female MH - *Fibrous Dysplasia, Polyostotic/complications MH - Humans MH - Letrozole MH - Male MH - *Puberty, Precocious/complications PMC - PMC5808444 MID - NIHMS939716 OTO - NOTNLM OT - Bicalutamide OT - Letrozole OT - McCune-Albright Syndrome OT - Precocious Puberty OT - Tamoxifen COIS- Disclosure The authors report no conflicts of interest in this work. EDAT- 2018/01/03 06:00 MHDA- 2019/06/14 06:00 PMCR- 2018/06/01 CRDT- 2018/01/03 06:00 PHST- 2018/01/03 06:00 [entrez] PHST- 2018/01/03 06:00 [pubmed] PHST- 2019/06/14 06:00 [medline] PHST- 2018/06/01 00:00 [pmc-release] AID - IdType="doi">10.17458/per.vol15.2017.nau.treatmentgirlsboys [pii] AID - 10.17458/per.vol15.2017.nau.treatmentgirlsboys [doi] PST - ppublish SO - Pediatr Endocrinol Rev. 2017 Dec;15(2):136-141. doi: 10.17458/per.vol15.2017.nau.treatmentgirlsboys. PMID- 34732164 OWN - NLM STAT- MEDLINE DCOM- 20211108 LR - 20211108 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 21 IP - 1 DP - 2021 Nov 3 TI - Job burnout and its impact on work ability in biosafety laboratory staff during the COVID-19 epidemic in Xinjiang. PG - 543 LID - 10.1186/s12888-021-03555-x [doi] LID - 543 AB - BACKGROUND: The coronavirus disease 2019 (COVID-19) has increased the physical and psychological stress of medical workers. This study was designed to investigate the prevalence and risk factors of job burnout and its impact on work ability among Biosafety Laboratory (BSL) staffs during the COVID-19 epidemic in Xinjiang. METHODS: A total of 7911 qualified BSL staffs in Xinjiang were investigated by electronic questionnaires. The Maslach Burnout Inventory-General Survey (MBI-GS) was used for job burnout survey. Work Ability Index (WAI) was used for work ability survey. The prevalence and risk factors of job burnout in BSL staffs were analyzed through chi square test, t-test and one-way ANOVA. And then, the influence of demographic and job-related variables, i.e., confounding factors, were eliminated to the greatest extent by the propensity score analysis (PSA) method, to investigate the impact of job burnout on work ability in BSL staffs. RESULTS: A total of 67.6% BSL staffs experienced job burnout. There were significant differences in the detection rate of job burnout among demographic and job-related variables, including gender, age, ethnicity, education, working years, professional title, marital status, number of night shift per month and overall sleep condition (all P < 0.05). The detection rate of job burnout in female was higher than that in male. The detection rates of job burnout in 45-50 years old, Han ethnicity, education of postgraduate or above, 11-20 years of working, intermediate professional title, married, staff with many night shifts per month and poor overall sleep condition were higher than that of other groups. The average burnout scores of the Emotional Exhaustion (EE), Cynicism (CY), Reduced Personal Accomplishment (PA) scale were 10.00 ± 5.99, 4.64 ± 4.59 and 15.25 ± 8.16, respectively. Multiple logistic regression analysis showed that the three dimensions of job burnout, i.e., EE, CY, PE, were negatively correlated with work ability and significantly affected the work ability of BSL staffs (all P < 0.001). CONCLUSIONS: Our results suggest that the prevalence of job burnout is extremely common among BSL staffs. In addition, the work ability decreases with the increase of job burnout and the improvement of job burnout can enhance work ability among BSL staffs. CI - © 2021. The Author(s). FAU - Lu, Yaoqin AU - Lu Y AD - Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. AD - Urumqi Center for Disease Control and Prevention, Urumqi, 830026, Xinjiang, China. FAU - Liu, Qi AU - Liu Q AD - Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. FAU - Yan, Huan AU - Yan H AD - Department of Nutrition and Food Hygiene, College of Public Health, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. AD - Xinjiang Engineering Technology Research Center for Green Processing of Nature Product Center, Xinjiang Autonomous Academy of Instrumental Analysis, Urumqi, Xinjiang, China. FAU - Gao, Sunyujie AU - Gao S AD - Urumqi Center for Disease Control and Prevention, Urumqi, 830026, Xinjiang, China. FAU - Liu, Tao AU - Liu T AD - Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. xjmult@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211103 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - *Burnout, Professional/epidemiology MH - *COVID-19 MH - Containment of Biohazards MH - *Epidemics MH - Female MH - Humans MH - Job Satisfaction MH - Laboratories MH - Male MH - Middle Aged MH - SARS-CoV-2 MH - Surveys and Questionnaires MH - Work Capacity Evaluation PMC - PMC8563825 OTO - NOTNLM OT - BSL staff OT - COVID-19 OT - Job burnout OT - Work ability; COIS- All authors have nothing to disclose in relation to the submitted work. EDAT- 2021/11/05 06:00 MHDA- 2021/11/09 06:00 PMCR- 2021/11/03 CRDT- 2021/11/04 05:25 PHST- 2021/06/27 00:00 [received] PHST- 2021/10/19 00:00 [accepted] PHST- 2021/11/04 05:25 [entrez] PHST- 2021/11/05 06:00 [pubmed] PHST- 2021/11/09 06:00 [medline] PHST- 2021/11/03 00:00 [pmc-release] AID - 10.1186/s12888-021-03555-x [pii] AID - 3555 [pii] AID - 10.1186/s12888-021-03555-x [doi] PST - epublish SO - BMC Psychiatry. 2021 Nov 3;21(1):543. doi: 10.1186/s12888-021-03555-x. PMID- 21724490 OWN - NLM STAT- MEDLINE DCOM- 20131219 LR - 20240103 IS - 0375-0906 (Print) IS - 0375-0906 (Linking) VI - 76 IP - 2 DP - 2011 Apr-Jun TI - [Guidelines for diagnosis and treatment of constipation in Mexico. C) Medical and surgical treatment]. PG - 141-54 AB - BACKGROUND: There are multiple therapeutic options for the management of constipation, from lifestyle modifications to the use of laxatives and in extreme cases surgery. OBJECTIVES AND METHODS: To establish the clinical guidelines for diagnosis and treatment of chronic constipation in Mexico we conducted a review of the literature regarding medical and surgical treatments for chronic constipation and have made recommendations based on evidence. RESULTS: Low water consumption, physical inactivity and low intake of fiber are conditions associated with chronic constipation, but the evidence to prove these associations is scarce. Bolus forming agents are useful in the management of constipation with normal colonic transit and defecation without dissynergia. Evidence supports the use of lactulose (IB) and polyethylene glycol (IA) as the most safe and effective agents in the long term in adults. The use of stimulant laxatives (docusate, picosulfate, senna) is recommended only for short periods. Tegaserod is an agonist of 5-HT4 receptors and there are many clinical trials supporting its effectiveness in the management of functional constipation (IA). However "their cardiovascular safety has been questioned recently. Biofeedback therapy is the gold standard in the management of constipation associated with pelvic floor dyssynergia. Surgical treatment is reserved for extreme cases of colonic inertia. CONCLUSIONS: The treatment of constipation should be based on the underlying pathophysiological mechanisms and the selection of drugs must be made according to the scientific evidence. FAU - Remes Troche, José María AU - Remes Troche JM AD - Laboratorio de Fisiología Digestiva, Instituto de Investigaciones Medico Biológicas, Universidad Veracruzana, México. jose.remes.troche@gmail.com FAU - Gómez Escudero, Octavio AU - Gómez Escudero O FAU - Icaza Chávez, María Eugenia AU - Icaza Chávez ME FAU - Noble Lugo, Alejandra AU - Noble Lugo A FAU - López Colombo, Aurelio AU - López Colombo A FAU - Bielsa, María Victoria AU - Bielsa MV FAU - Charúa Guindic, Luis AU - Charúa Guindic L CN - Asociación Mexicana de Gastroenterología LA - spa PT - English Abstract PT - Journal Article PT - Practice Guideline PT - Review TT - Guías de diagnóstico y tratamiento del estreñimiento en México. C) Tratamiento médico y quirúrgico. PL - Mexico TA - Rev Gastroenterol Mex JT - Revista de gastroenterologia de Mexico JID - 0404271 RN - 0 (Laxatives) SB - IM CIN - Rev Gastroenterol Mex. 2012 Jan-Mar;77(1):47-8; author reply 49-50. PMID: 22450022 MH - Chronic Disease MH - Constipation/diagnosis/drug therapy/surgery/*therapy MH - Electric Stimulation Therapy MH - Evidence-Based Medicine MH - Feedback, Physiological MH - Humans MH - Laxatives/therapeutic use MH - Life Style MH - Mexico EDAT- 2011/07/05 06:00 MHDA- 2013/12/20 06:00 CRDT- 2011/07/05 06:00 PHST- 2011/07/05 06:00 [entrez] PHST- 2011/07/05 06:00 [pubmed] PHST- 2013/12/20 06:00 [medline] AID - 03750906762010 [pii] PST - ppublish SO - Rev Gastroenterol Mex. 2011 Apr-Jun;76(2):141-54. PMID- 26651242 OWN - NLM STAT- MEDLINE DCOM- 20160503 LR - 20160206 IS - 1080-3548 (Print) IS - 1080-3548 (Linking) VI - 22 IP - 1 DP - 2016 TI - Foot model for tracking temperature of safety boot insoles: application to different insole materials in firefighter boots. PG - 12-9 LID - 10.1080/10803548.2015.1105521 [doi] AB - This research is based on the development of a human foot model to study the temperature conditions of a foot bottom surface under extreme external conditions. This foot model is made by combining different manufacturing techniques to enable the simulation of bones and tissues, allowing the placement of sensors on its surface to track the temperature values of different points inside a shoe. These sensors let researchers capture valuable data during a defined period of time, making it possible to compare the features of different safety boots, socks or soles, among others. In this case, it has been applied to compare different plantar insole materials, placed into safety boots on a high-temperature surface. FAU - García-Hernández, César AU - García-Hernández C AD - a University of Zaragoza , Spain. FAU - Sánchez-Álvarez, Eduardo J AU - Sánchez-Álvarez EJ AD - a University of Zaragoza , Spain. FAU - Huertas-Talón, José-Luis AU - Huertas-Talón JL AD - a University of Zaragoza , Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Int J Occup Saf Ergon JT - International journal of occupational safety and ergonomics : JOSE JID - 9507598 SB - IM MH - Equipment Design MH - *Firefighters MH - *Foot MH - *Hot Temperature MH - Humans MH - *Models, Biological MH - Occupational Exposure/prevention & control MH - Occupational Health MH - Shoes/*standards MH - Time Factors OTO - NOTNLM OT - extreme temperatures OT - firefighter OT - foot OT - safety boot EDAT- 2015/12/15 06:00 MHDA- 2016/05/04 06:00 CRDT- 2015/12/15 06:00 PHST- 2015/12/15 06:00 [entrez] PHST- 2015/12/15 06:00 [pubmed] PHST- 2016/05/04 06:00 [medline] AID - 10.1080/10803548.2015.1105521 [doi] PST - ppublish SO - Int J Occup Saf Ergon. 2016;22(1):12-9. doi: 10.1080/10803548.2015.1105521. PMID- 32258467 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 6 IP - 3 DP - 2020 Mar TI - Design, qualification & manufacture of ITER gravity supports. PG - e03609 LID - 10.1016/j.heliyon.2020.e03609 [doi] LID - e03609 AB - As one of the key components to support all the magnet coils, the GS faces engineering challenge to its operational safety throughout the design, qualification and manufacturing process as a result of extreme loading condition. The structural safety of GS was confirmed by both the FEM analysis and the semi-prototype engineering test after a long time of design, qualification, manufacture and assembly. Welding the cooling pipe to the flexible plate without obvious deformation as well as tightening uniformly and precisely all the tie rods to clamp the plates were carried out successfully during manufacturing. The result of final vacuum leakage test indicates that the GS can not only meet the ITER vacuum requirement but also have no slow out-gassing. The first set of GS which has passed the ITER acceptance test is to be delivered to ITER construction site soon. CI - © 2020 The Authors. FAU - Lee, P Y AU - Lee PY AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Hou, B L AU - Hou BL AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Sun, Z C AU - Sun ZC AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Kang, D A AU - Kang DA AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Han, S L AU - Han SL AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Zhang, T AU - Zhang T AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Xu, D AU - Xu D AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Yan, T F AU - Yan TF AD - Southwestern Institute of Physics (SWIP), P. O. Box 432, Chengdu, China. FAU - Zhang, B AU - Zhang B AD - China International Nuclear Fusion Energy Program Executive Center (CNDA), Fuxing Road, Beijing, China. LA - eng PT - Journal Article DEP - 20200331 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC7114748 OTO - NOTNLM OT - Energy OT - Energy economics OT - Energy sustainability OT - Engineering test OT - FEM analysis OT - Gravity support OT - Leakage test OT - Nuclear engineering OT - Structural engineering EDAT- 2020/04/08 06:00 MHDA- 2020/04/08 06:01 PMCR- 2020/03/31 CRDT- 2020/04/08 06:00 PHST- 2019/07/11 00:00 [received] PHST- 2019/11/04 00:00 [revised] PHST- 2020/03/12 00:00 [accepted] PHST- 2020/04/08 06:00 [entrez] PHST- 2020/04/08 06:00 [pubmed] PHST- 2020/04/08 06:01 [medline] PHST- 2020/03/31 00:00 [pmc-release] AID - S2405-8440(20)30454-0 [pii] AID - e03609 [pii] AID - 10.1016/j.heliyon.2020.e03609 [doi] PST - epublish SO - Heliyon. 2020 Mar 31;6(3):e03609. doi: 10.1016/j.heliyon.2020.e03609. eCollection 2020 Mar. PMID- 9034637 OWN - NLM STAT- MEDLINE DCOM- 19970429 LR - 20200225 IS - 0160-9289 (Print) IS - 1932-8737 (Electronic) IS - 0160-9289 (Linking) VI - 20 IP - 2 DP - 1997 Feb TI - Percutaneous transvenous mitral commissurotomy versus surgical commissurotomy in the treatment of mitral stenosis. PG - 99-106 AB - There is no doubt that percutaneous transvenous mitral commissurotomy (PTMC) in experienced centers is associated with a low risk of major complications and yields excellent immediate and long-term outcome. Although previous observational studies on both PTMC and surgical commissurotomy have indicated similar outcome between the two treatment strategies in terms of valve area improvement and risk of major complication (death, thromboembolism and significant resultant mitral regurgitation), it was not until recently that several prospective randomized trials comparing the two procedures and involving > 470 patients with favorable valve characteristics (pliable, noncalcified valve with mild subvalvular disease and no or mild mitral regurgitation), have confirmed that PTMC is indeed just as, if not more, effective as surgical commissurotomy. The late restenosis rate at up to 3-year follow-up appears comparable. Furthermore, PTMC has other additional benefits. It is nontraumatic, may be repeated without additional risk, and has been shown to be an extremely useful and efficacious palliative tool in those with end-stage mitral stenosis or with unfavorable valve anatomy who refuse surgery, and in certain subset of patients at high surgical risk because of medical comorbidities. FAU - Lau, K W AU - Lau KW AD - Singapore Heart Centre, Singapore. FAU - Ding, Z P AU - Ding ZP FAU - Hung, J S AU - Hung JS LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - United States TA - Clin Cardiol JT - Clinical cardiology JID - 7903272 SB - IM MH - Angioplasty, Balloon, Coronary MH - *Catheterization/adverse effects/methods MH - Clinical Trials as Topic MH - Follow-Up Studies MH - Humans MH - Mitral Valve Insufficiency/diagnostic imaging/therapy MH - Mitral Valve Stenosis/diagnostic imaging/*therapy MH - Postoperative Complications MH - Radiography MH - Risk Factors MH - Safety MH - Treatment Outcome PMC - PMC6656037 EDAT- 1997/02/01 00:00 MHDA- 1997/02/01 00:01 PMCR- 2009/02/03 CRDT- 1997/02/01 00:00 PHST- 1997/02/01 00:00 [pubmed] PHST- 1997/02/01 00:01 [medline] PHST- 1997/02/01 00:00 [entrez] PHST- 2009/02/03 00:00 [pmc-release] AID - CLC4960200204 [pii] AID - 10.1002/clc.4960200204 [doi] PST - ppublish SO - Clin Cardiol. 1997 Feb;20(2):99-106. doi: 10.1002/clc.4960200204. PMID- 30914545 OWN - NLM STAT- MEDLINE DCOM- 20190823 LR - 20190823 IS - 0385-0684 (Print) IS - 0385-0684 (Linking) VI - 46 IP - 2 DP - 2019 Feb TI - [Analysis of Hepatectomy for Extreme Elderly Patients with Hepatocellular Carcinoma]. PG - 315-317 AB - Although the first-line treatment for hepatocellular carcinoma(HCC)is hepatectomy, extreme elderly(80 years or older) patients often tend to have a variety of underlying diseases and decreased cardiopulmonary function, which means that surgery involves a high risk. In this case, we examined the safety and efficacy of hepatectomy performed in an extreme elderly patient with HCC. Of the patients with HCC that underwent initial hepatectomy at Kobe University Hospital(n=348)between 2009 and 2015, 23 patients aged 80 years or older at the time of surgery(Group 1, n=23)and those younger than 80 years at the time(Group 2, n=325)were compared, based on parameters related to safety and prognosis. We did not identify differences between the 2 groups with respect to blood loss and operating time. Intraoperative blood transfusion was more common in Group 1. There was no significant difference between the 2 groups with respect to complications of Grade Ⅲ or higher. The median survival of Group 2 patients following hepatectomy(42 months)was better than that of Group 1 patients(34 months), but there was no significant difference between the 2 groups(p=0.429). Furthermore, when the same parameters were compared after adjusting for and matching propensity scores, there were no significant differences in complications, hospitalization periods, and prognosis between the 2 groups. Through proper assessment of oncologic factors and patient risk factors, hepatectomy can be performed safely and effectively even for extreme elderly patients with HCC. If there is no other disease regulating the prognosis, we can expect to achieve similar prognosis in non-extreme elderly patients. Hence, treatments should not be limited solely based on a patient being extremely elderly; rather, proactive treatments should be considered. FAU - Tsugawa, Daisuke AU - Tsugawa D AD - Dept. of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine. FAU - Kido, Masahiro AU - Kido M FAU - Tanaka, Motofumi AU - Tanaka M FAU - Kinoshita, Hisoka AU - Kinoshita H FAU - Komatsu, Shohei AU - Komatsu S FAU - Awazu, Masahide AU - Awazu M FAU - Gon, Hidetoshi AU - Gon H FAU - Yamashita, Hironori AU - Yamashita H FAU - Shirakawa, Sachiyo AU - Shirakawa S FAU - Mukubo, Hideyo AU - Mukubo H FAU - Terai, Sachio AU - Terai S FAU - Ueno, Kimihiko AU - Ueno K FAU - Toyama, Hirochika AU - Toyama H FAU - Ajiki, Tetsuo AU - Ajiki T FAU - Fukumoto, Takumi AU - Fukumoto T LA - jpn PT - Journal Article PL - Japan TA - Gan To Kagaku Ryoho JT - Gan to kagaku ryoho. Cancer & chemotherapy JID - 7810034 MH - Aged, 80 and over MH - *Carcinoma, Hepatocellular/surgery MH - *Hepatectomy MH - Humans MH - *Liver Neoplasms/surgery MH - Prognosis MH - Risk Factors EDAT- 2019/03/28 06:00 MHDA- 2019/08/24 06:00 CRDT- 2019/03/28 06:00 PHST- 2019/03/28 06:00 [entrez] PHST- 2019/03/28 06:00 [pubmed] PHST- 2019/08/24 06:00 [medline] PST - ppublish SO - Gan To Kagaku Ryoho. 2019 Feb;46(2):315-317. PMID- 35107219 OWN - NLM STAT- MEDLINE DCOM- 20220415 LR - 20220415 IS - 2366-9608 (Electronic) IS - 2366-9608 (Linking) VI - 6 IP - 3 DP - 2022 Mar TI - Boosting Vascular Imaging-Performance and Systemic Biosafety of Ultra-Small NaGdF(4) Nanoparticles via Surface Engineering with Rationally Designed Novel Hydrophilic Block Co-Polymer. PG - e2101145 LID - 10.1002/smtd.202101145 [doi] AB - Revealing the anatomical structures, functions, and distribution of vasculature via contrast agent (CA) enhanced magnetic resonance imaging (MRI) is crucial for precise medical diagnosis and therapy. The clinically used MRI CAs strongly rely on Gd-chelates, which exhibit low T(1) relaxivities and high risks of nephrogenic systemic fibrosis (NSF) for patients with renal dysfunction. It is extremely important to develop high-performance and safe CAs for MRI. Herein, it is reported that ultra-small NaGdF(4) nanoparticles (UGNs) can serve as an excellent safe MRI CA via surface engineering with rationally designed novel hydrophilic block co-polymer (BP(n) ). By optimizing the polymer molecular weights, the polymer-functionalized UGNs (i.e., UGNs-BP(14) ) are obtained to exhibit remarkably higher relaxivity (11.8 mm(-1) s(-1) at 3.0 T) than Gd-DTPA (3.6 mm(-1) s(-1) ) due to their ultracompact and abundant hydrophilic surface coating. The high performance of UGNs-BP(14) enables us to sensitively visualize microvasculature with a small diameter of ≈0.17 mm for up to 2 h, which is the thinnest blood vessel and the longest time window for low field (1.0 T) MR angiography ever reported, and cannot be achieved by using the clinically used Gd-DTPA under the same conditions. More importantly, renal clearable UGNs-BP(14) show lower risks of inducing NSF in comparison with Gd-DTPA due to their negligible release of Gd(3+) ions after modification with the novel hydrophilic block copolymer. The study presents a novel avenue for boosting imaging-performance and systemic biosafety of UGNs as a robust MRI CA with great potential in precise diagnosis of vasculature-related diseases. CI - © 2022 Wiley-VCH GmbH. FAU - Jiang, Zhilin AU - Jiang Z AD - Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, P. R. China. FAU - Xia, Bin AU - Xia B AD - School of Chemistry and Chemical Engineering, Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P. R. China. FAU - Ren, Feng AU - Ren F AD - Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, P. R. China. FAU - Bao, Bolin AU - Bao B AD - Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, P. R. China. AD - Department of Radiology, Affiliated Hospital 3, Soochow University, Changzhou, 213003, P. R. China. FAU - Xing, Wei AU - Xing W AD - Department of Radiology, Affiliated Hospital 3, Soochow University, Changzhou, 213003, P. R. China. FAU - He, Tao AU - He T AD - School of Chemistry and Chemical Engineering, Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei, Anhui, 230009, P. R. China. FAU - Li, Zhen AU - Li Z AUID- ORCID: 0000-0003-0333-7699 AD - Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, P. R. China. LA - eng GR - 81971671/National Natural Science Foundation of China/ GR - 2018YFA0208800/National Key Research and Development Program of China/ GR - BE2019660/Jiangsu Provincial Key Research and Development Program/ GR - N312861019/Suzhou Municipal Science and Technology Bureau/ GR - Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection/ GR - Priority Academic Development Program of Jiangsu Higher Education Institutions/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220202 PL - Germany TA - Small Methods JT - Small methods JID - 101724536 RN - 0 (Contrast Media) RN - 0 (Polymers) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Containment of Biohazards MH - Contrast Media/adverse effects MH - *Gadolinium DTPA/chemistry MH - Humans MH - *Nanoparticles/adverse effects MH - Polymers/chemistry MH - Tomography, X-Ray Computed OTO - NOTNLM OT - MRI contrast agents OT - block co-polymers OT - nephrogenic systemic fibrosis OT - ultra-small NaGdF 4 nanoparticles OT - vascular imaging EDAT- 2022/02/03 06:00 MHDA- 2022/04/16 06:00 CRDT- 2022/02/02 08:41 PHST- 2021/12/03 00:00 [revised] PHST- 2021/09/15 00:00 [received] PHST- 2022/02/03 06:00 [pubmed] PHST- 2022/04/16 06:00 [medline] PHST- 2022/02/02 08:41 [entrez] AID - 10.1002/smtd.202101145 [doi] PST - ppublish SO - Small Methods. 2022 Mar;6(3):e2101145. doi: 10.1002/smtd.202101145. Epub 2022 Feb 2. PMID- 22337145 OWN - NLM STAT- MEDLINE DCOM- 20130314 LR - 20121005 IS - 1532-2149 (Electronic) IS - 1090-3801 (Linking) VI - 16 IP - 3 DP - 2012 Mar TI - Coping when pain is a potential threat: the efficacy of acceptance versus cognitive distraction. PG - 390-400 LID - 10.1002/j.1532-2149.2011.00019.x [doi] AB - This experiment investigated the impact of brief training in acceptance versus distraction-based pain management on experimental pain tolerance in conditions of lower and higher potential threats. One hundred fifty-one pain-free Chinese adults (93 women, 58 men) randomly assigned to acceptance, distraction or pain education control conditions engaged in a cold pressor test (CPT) after reading validated orienting information designed to prime either the safety of the CPT (lower threat) or symptoms and damaging effects of exposure to extreme cold (higher threat). A 2 (threat level) × 3 (training strategy) analysis of covariance, controlling for pre-intervention pain tolerance and education, indicated the acceptance group was more pain tolerant than other training groups. This main effect was qualified by an interaction with threat level: in the lower threat condition, acceptance group participants were more pain tolerant than peers in the distraction or pain education groups while no training group differences were found in the higher threat condition. Supplementary analyses identified catastrophizing as a partial mediator of training group differences in pain tolerance. In summary, findings suggested acceptance-based coping is superior to distraction as a means of managing experimental pain, particularly when pain sensations are viewed as comparatively low in potential threat. CI - © 2011 European Federation of International Association for the Study of Pain Chapters. FAU - Jackson, T AU - Jackson T AD - Key Laboratory of Cognition & Personality, Southwest University, Chongqing, China. toddjackson@hotmail.com FAU - Yang, Z AU - Yang Z FAU - Li, X AU - Li X FAU - Chen, H AU - Chen H FAU - Huang, X AU - Huang X FAU - Meng, J AU - Meng J LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20111219 PL - England TA - Eur J Pain JT - European journal of pain (London, England) JID - 9801774 SB - IM MH - *Adaptation, Psychological MH - Adolescent MH - Adult MH - *Attention MH - Female MH - Humans MH - Male MH - Pain/*psychology MH - Pain Measurement MH - Pain Threshold/*psychology MH - Patient Education as Topic EDAT- 2012/02/18 06:00 MHDA- 2013/03/15 06:00 CRDT- 2012/02/17 06:00 PHST- 2011/09/03 00:00 [accepted] PHST- 2012/02/17 06:00 [entrez] PHST- 2012/02/18 06:00 [pubmed] PHST- 2013/03/15 06:00 [medline] AID - 10.1002/j.1532-2149.2011.00019.x [doi] PST - ppublish SO - Eur J Pain. 2012 Mar;16(3):390-400. doi: 10.1002/j.1532-2149.2011.00019.x. Epub 2011 Dec 19. PMID- 25086705 OWN - NLM STAT- MEDLINE DCOM- 20150203 LR - 20141209 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 134 DP - 2014 Oct TI - Extremely cold and hot temperatures increase the risk of diabetes mortality in metropolitan areas of two Chinese cities. PG - 91-7 LID - S0013-9351(14)00218-7 [pii] LID - 10.1016/j.envres.2014.06.022 [doi] AB - BACKGROUND: Numerous studies have reported the association between ambient temperature and mortality. However, few studies have focused on the effects of extreme temperatures on diabetes mortality, particularly in China. The objective of the present study was to assess the effects of extremely cold and hot temperatures on diabetes mortality in urban areas of Harbin and Chongqing in China to provide scientific evidence for public health policy implementation to respond to challenges in diabetes mortality because of extreme temperature events. METHODS: A double threshold B-spline distributed lag non-linear model (DLNM) was used to investigate the effects of extremely cold and hot temperatures on diabetes mortality from lag 0 to 30 days, after controlling for potential confounders including air pollutants. The unit risk, which is the elevated cumulative risk of diabetes mortality caused by each 1 °C change in extremely cold and hot temperatures during certain lag days, was estimated for extreme cold and heat using simple regression analysis. RESULTS: Significant associations between both extreme hot and cold temperatures and diabetes mortality were observed in Harbin and Chongqing for different lag lengths. In Harbin, the extreme cold effects on diabetes mortality were delayed by three days and lasted for six days (lag 3-8), with the highest risk (RR 95% CI: 1.223,1.054-1.418 for -23 °C) at lag 5. The hot effects were delayed one day and lasted for three days (lag 1-3), with the peak RR (1.343: 1.080-1.670 for 37 °C) at lag 2. In Chongqing, the cold effects on diabetes mortality were delayed by seven days and lasted for four days (lag 7-10), with the highest risk (1.201: 1.006-1.434 for 4 °C) at lag 7. The hot effects peaked (1.811: 1.083-3.027 for 41 °C) at lag 0 and lasted for 2 days (lag 0-1). The unit risk for cold and hot effects was 12.9% (95% CI: 2.5-33.7%) and 16.5% (95% CI: 3.8-39.1%) in Harbin and 12.5% (95% CI: -4.7 to 47.5%) and 19.7% (95% CI: 3.9-48.5%) in Chongqing, respectively. CONCLUSIONS: The results indicate that both extremely cold and hot temperatures increase diabetes mortality in different manners in Harbin and Chongqing. Diabetes education programs should include information on either managing or combating the effects of extreme hot and cold weather. CI - Copyright © 2014 Elsevier Inc. All rights reserved. FAU - Li, Yonghong AU - Li Y AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100021, China. FAU - Lan, Li AU - Lan L AD - Harbin Center for Disease Control and Prevention, Harbin 150056, China. FAU - Wang, Yulin AU - Wang Y AD - Chongqing Center for Disease Control and Prevention, Chongqing 404000, China. FAU - Yang, Chao AU - Yang C AD - Harbin Center for Disease Control and Prevention, Harbin 150056, China. FAU - Tang, Wenge AU - Tang W AD - Chongqing Center for Disease Control and Prevention, Chongqing 404000, China. FAU - Cui, Guoquan AU - Cui G AD - Harbin Center for Disease Control and Prevention, Harbin 150056, China. FAU - Luo, Shuquan AU - Luo S AD - Chongqing Center for Disease Control and Prevention, Chongqing 404000, China. FAU - Cheng, Yibin AU - Cheng Y AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100021, China. FAU - Liu, Yingchun AU - Liu Y AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100021, China. FAU - Liu, Jingyi AU - Liu J AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100021, China. FAU - Jin, Yinlong AU - Jin Y AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100021, China. Electronic address: iehs.chinacdc@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140801 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 SB - IM MH - China/epidemiology MH - *Climate MH - *Cold Temperature MH - Diabetes Mellitus/*mortality MH - *Hot Temperature MH - Humans MH - Risk Factors MH - Urban Population OTO - NOTNLM OT - Air pollution OT - Diabetes mortality OT - Extremely cold effect OT - Extremely hot effect OT - Lag-effect OT - Temperature EDAT- 2014/08/05 06:00 MHDA- 2015/02/04 06:00 CRDT- 2014/08/04 06:00 PHST- 2014/03/13 00:00 [received] PHST- 2014/05/30 00:00 [revised] PHST- 2014/06/22 00:00 [accepted] PHST- 2014/08/04 06:00 [entrez] PHST- 2014/08/05 06:00 [pubmed] PHST- 2015/02/04 06:00 [medline] AID - S0013-9351(14)00218-7 [pii] AID - 10.1016/j.envres.2014.06.022 [doi] PST - ppublish SO - Environ Res. 2014 Oct;134:91-7. doi: 10.1016/j.envres.2014.06.022. Epub 2014 Aug 1. PMID- 24779310 OWN - NLM STAT- MEDLINE DCOM- 20140530 LR - 20191112 IS - 1433-6510 (Print) IS - 1433-6510 (Linking) VI - 60 IP - 4 DP - 2014 TI - [Single-donor (apheresis) platelets and pooled whole-blood-derived platelets--significance and assessment of both blood products]. PG - S1-39 AB - The transfusion efficacy of ATK, which contain fully functional platelets, is beyond all doubt. The equivalence of ATK and PTK has been subject of many studies. Some of those studies show the superiority of ATK's, while others do not, but there have been no studies that demonstrated a superiority of PTK's. The superiority of platelets stored in plasma and in third generation additive solution was demonstrated in clinical studies; therefore, it cannot be said that all the platelet concentrates on the German market are equivalent in efficacy. Of decisive importance, above all, is the risk of transfusion-transmitted infections with known pathogens, or those not yet discovered. This risk is different for ATK compared to PTK. Taking this difference in risk and the difference in donor exposure of transfused patients into account, it can definitely be said that ATK and PTK are not equivalent. In 2012, the Robert-Koch-Institute (RKI) published a mathematical risk model for different platelet concentrates and assessed the risk of transmitting known pathogens such as HIV, HCV, and HBV. The risk was higher for PTK compared to ATK. The relative risks for PTK derived from 4BCs were 2.2 (95%--CI: 2.1-2.4) for HIV, 2.7 (95%--CI: 2.5-3.0) for HCV, and 2.2 (95%--CI: 2.8-3.7) for HBV. At the present time, these are the relative risks of transfusion-transmitted infections with the traditional pathogens for PTK compared to ATK. In addition to the RKI assessed risks, there is the theoretical risk of a new, unknown agent, transmitted through blood exposure. The magnitude of this risk is hardly predictable for PTK. The experience gathered so far, especially in the last three decades, with the emergence of HIV, prions, and West Nil virus, shows that the biological nature of a next transfusion-transmissible infectious agent cannot be predictable. This agent, if we think at a conventional sexually transmissible agent with nucleic acid and long latent period, would spread first in areas with high population density and thereby reduce the theoretical advantage of ATK (but definitely would not nullify it!). It is equally plausible, however, that this agent would behave like a prion, non-sexual transmission, or like a West-Nil virus, a non-contagious vector-transmitted agent. For PTK this would mean a relative risk up to 4 times (PTK from 4 BCs) or 5 times (PTK from 5 BCs) higher than the risk estimated by the Robert-Koch-Institute. If, taking the passive surveillance data and the changing variables (donor frequency, donor population, and donor location) into account, the risk of transmission of an infection via ATK (exposure to 1 donor) with HIV, HCV, and HBV moves closer to the higher risk of PTK (exposure to 4 or 8 donors, in case of double ATK per patient), this result of the risk model calculation by no means indicates any equivalency between PTK and ATK with respect to the risk of transmission of infection. The modifiable variables of donor frequency, donor population, and donor location need to be modified, as scientific deductions, in such a way that the avoidable risk of ATK which is influenced by these variables can be corrected to the minimum risk of a transmission of infection of HIV, HBV, and HCV via ATK in comparison to PTK. The minimum risk of a possible transmission of infection via ATK (exposure to 1 donor) is the basic intrinsic risk of each individual blood donation. The basic intrinsic risk increases relative to the number of blood donations or exposure to donors (PtK has an unalterable, production-dependent exposure to 4 or 8 donors). Let us consider a 1:1.000 prevalence for a new pathogen, which is spread equally in each donor population (apheresis and whole blood) and the present case of approximately 500,000 transfused platelet concentrates in Germany. This means that for the production of 4 PTK about 2 million donations are processed, 2,000 infectious Buffy-Coats are obtained and, thereby, 2,000 infectious PTK. In the case of ATK, considering five (5) donations per year, theoretically, it would mean 100 donors infected and 500 infectious ATK. Considering 15 apheresis donations per donor per year, this would mean that 33 donors are infected, but still 500 infectious ATK would be produced. The prion is an example of a pathogen that, although its existence is well known, cannot be proven or pathogen-reduced. In addition, it has a very long incubation period compared to the donation intervals. Due to the manufacturing process, PTK has a 4-fold higher donor exposure and therefore a 4-fold higher risk for transfusion-transmitted infections compared to ATK. If a patient needs the transfusion of two platelet concentrates, by transfusing a double-ATK from the same donor the risk of transfusion-transmitted infections will remain the same. On the other hand, the risk will increase by 8-fold by transfusing two PTK. The only current possibility to prevent or to minimize the risk of infection with prions is to minimize the donor exposure by transfusing ATK instead of PTK. Hypothetical risk scenarios carry significant weight in law. This can be seen in the constant rulings of the German Federal Supreme Court (Bundesgerichtshofs (BGH)) on the so-called hypothetical risk explanations (BGH, NJW 1996, 776, 777; 2000, 1784, 1787; 2005, 2614, 2616). Therefore, a risk does not need to be confirmed to be subject to compulsory explanation. It is sufficient that serious voices in the medical scientific community point to specific risks, which cannot be set aside as insignificant outside opinions, but must be viewed as serious warnings. According to the rulings, patients must even be informed of rare and often extremely rare risks, which could, should they come true, significantly impact daily life and, despite their rarity, are specific to the treatment and are startling for the ordinary person (BGH, 15.02.2000- VI ZR 48199 -; BGH, 30.11.2004 - VI ZR 209104 -; OLG Hamm, 29.09.2010 - 1-3 V 169109). These conditions have been fulfilled for PTK according to current knowledge, especially since, in the meantime in several rulings, the federal supreme court has required the reference to as yet unknown risks (refer to BGH, 13.06.2006 - VI ZR 323104 - for the use of new medical treatment methods, BGH, 27.06.2007 - VI ZR 55105 for experimental therapy using new, unapproved medication BGH, 06.07.2010 - VI ZR 198109 - for unknown risks cannot be excluded, for example based on anatomical conditions). ATK and PTK are therapeutic alternatives with the same range of indications for treatment using thrombocytes, however, with differing risks of infection, with different exposures to donors, and with different efficacy. ATK and PTK. ATK and PTK are therapeutic alternatives in terms of pharmaceutical law based on the different risks and the different quality. Patients must be informed of therapeutic alternatives such as ATK and PTK according to the patient rights law. Denial of reimbursement for additional fees for ATK by individual insurance companies (or paying authorities) deviates blatantly, as seen in the ruling of the Social Court of of the Saarland in this matter, from the basic requirement of the Transfusion Law (Transfusionsgesetz (TFG)) and is legally incorrect. The legality of the question whether the transfusion of ATK is indicated or if PTK had sufficed, is not allowable within the context of an MDK-Test according to subsection 275 ff. SGB V. The denial is a direct infringment on the treatment authority of the attending hospital physician and is illegal according to subsection 275 Abs. 5 SGBV. It is certainly possible to establish a full ATK supply and can be immediately realized by increasing donation rates from 5 to 8.3 apheresis donations per year in the current scenario of apheresis structure and donor population. The donation interval between two apheresis donations would be 49 days. A complete supply with ATK can also be immediately implemented by enlarging the donor population, keeping the current apheresis donation frequency. The donor pool must be increased by 24,576 donors, which means a 67% increase of the existing donor population. A transition to an ATK supply that can cover the entire demand can certainly be realized in a short period of time, while assuring a complete supply with PTK is not a realistic option. All existing studies advise taking extreme caution with any alternative to the current German gold standard for the treatment of hyporegenerative thrombocytopenia. A prophylactic transfusion of a non-pathogen-inactivated platelet concentrate with on average 3 x 10(11) platelets is recommended when the platelet count drops below the threshold of 10,000/microL. All other alternatives to this strategy show an increase in intracranial bleeding events. The existing studies on platelet dose (PLADO-Trial and StoP-Trial) do not recommend deviating from 3 x 10(11) platelets per unit. On the contrary, these studies demonstrate that the only practicable way is to individually correlate every platelet transfusion to the patient body surface. Considering the current knowledge, it is not justified to lower the standard dose and, for certain patient groups, to switch from prophylaxis to therapeutic platelet transfusion. Applying ATK or PTK with a lower platelet content and only for therapeutic purposes, could considerably increase the bleeding risk, especially for WHO grades III and IV. This will also affect all the patients who receive an induction treatment. Through pathogen reduction, in parallel with platelet loss (Apoptosis), the function of the treated platelets is impaired. Alternatively, the cell destruction caused during this process could result in a release of platelet microRNA directly into the supernatant or in microvesicles. This reduction of microRNA will affect the storage of the platelets. (ABSTRACT TRUNCATED) FAU - Hitzler, Walter E AU - Hitzler WE LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Apherese- und Pool-Thrombozytenkonzentrat--Wertigkeit und Bewertung beider Blutkomponenten. PL - Germany TA - Clin Lab JT - Clinical laboratory JID - 9705611 SB - IM MH - Blood Component Removal MH - *Blood Platelets MH - Humans MH - Patient Safety MH - Platelet Transfusion MH - Risk Assessment EDAT- 2014/05/02 06:00 MHDA- 2014/05/31 06:00 CRDT- 2014/05/01 06:00 PHST- 2014/05/01 06:00 [entrez] PHST- 2014/05/02 06:00 [pubmed] PHST- 2014/05/31 06:00 [medline] AID - 10.7754/clin.lab.2014.140210 [doi] PST - ppublish SO - Clin Lab. 2014;60(4):S1-39. doi: 10.7754/clin.lab.2014.140210. PMID- 26318688 OWN - NLM STAT- MEDLINE DCOM- 20160722 LR - 20151010 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 538 DP - 2015 Dec 15 TI - Long-term variations in the association between ambient temperature and daily cardiovascular mortality in Shanghai, China. PG - 524-30 LID - S0048-9697(15)30601-X [pii] LID - 10.1016/j.scitotenv.2015.08.097 [doi] AB - OBJECTIVE: The objective of this study was to explore the long-term variation in the association between ambient temperature and daily cardiovascular (CVD) mortality in Shanghai, China. MATERIALS AND METHODS: We collected daily data on ambient temperature and CVD mortality from a central urban district in Shanghai, China, during the period from 1981 to 2012. We used overdispersed generalized additive Poisson regression together with a distributed lag nonlinear model to estimate potentially lagged and nonlinear effects of temperature on CVD mortality after controlling for the seasonality, relative humidity, day of the week, holidays and population size. To allow for the evaluation of long-term variations in the effects, we divided the entire study period into six sub-periods (1981-1985, 1986-1990, 1991-1995, 1996-2000, 2001-2005, and 2006-2012) and analyzed the effect estimates in each sub-period separately. RESULTS: The association between temperature and daily CVD mortality was J-shaped with both low and high temperatures increasing the risk of CVD deaths. The effects of extremely low temperatures were delayed and persisted for two weeks, while extreme hot effects were limited to the first five days followed by a significant mortality displacement (9days). The relative risks (RRs) of extremely low, moderately low, moderately high, and extremely high temperatures comparing the 1st, 10th, 90th, and 99th percentile with the reference temperature (26°C) over the cumulative lags of 0-14days were 1.95 [95% confidence interval (CI): 1.84,2.07], 1.61 (95% CI: 1.57,1.66), 1.03 (95% CI: 1.01,1.05), and 1.14 (95% CI: 1.07,1.21). The RRs for extremely low and moderately low temperature attenuated substantially from 9.78 and 5.52 in 1981-1985 to 1.42 and 1.18 in 2006-2012, respectively, but the RRs remained almost stable for extremely high and moderately high temperatures. CONCLUSIONS: This time-series study suggested that there might have been some human adaptation to low ambient temperature in Shanghai, China, over the last 3 decades. CI - Copyright © 2015 Elsevier B.V. All rights reserved. FAU - Yang, Changyuan AU - Yang C AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. FAU - Meng, Xia AU - Meng X AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai, China. FAU - Cai, Jing AU - Cai J AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. FAU - Zhao, Zhuohui AU - Zhao Z AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. FAU - Wan, Yue AU - Wan Y AD - Division of Environment and Health Management, Department of Science, Technology and Standards, Ministry of Environmental Protection, China. Electronic address: wan.yue@mep.gov.cn. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai, China. Electronic address: kanh@fudan.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150828 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Air Pollutants) SB - IM MH - Air Pollutants/analysis MH - Cardiovascular Diseases/*mortality MH - China/epidemiology MH - Environmental Exposure/*statistics & numerical data MH - *Temperature OTO - NOTNLM OT - Cardiovascular disease OT - Mortality OT - Temperature OT - Time-series EDAT- 2015/09/01 06:00 MHDA- 2016/07/23 06:00 CRDT- 2015/08/31 06:00 PHST- 2015/04/22 00:00 [received] PHST- 2015/07/22 00:00 [revised] PHST- 2015/08/17 00:00 [accepted] PHST- 2015/08/31 06:00 [entrez] PHST- 2015/09/01 06:00 [pubmed] PHST- 2016/07/23 06:00 [medline] AID - S0048-9697(15)30601-X [pii] AID - 10.1016/j.scitotenv.2015.08.097 [doi] PST - ppublish SO - Sci Total Environ. 2015 Dec 15;538:524-30. doi: 10.1016/j.scitotenv.2015.08.097. Epub 2015 Aug 28. PMID- 15066809 OWN - NLM STAT- MEDLINE DCOM- 20040902 LR - 20240323 IS - 0099-2240 (Print) IS - 1098-5336 (Electronic) IS - 0099-2240 (Linking) VI - 70 IP - 4 DP - 2004 Apr TI - Characterization of Bacillus probiotics available for human use. PG - 2161-71 AB - Bacillus species (Bacillus cereus, Bacillus clausii, Bacillus pumilus) carried in five commercial probiotic products consisting of bacterial spores were characterized for potential attributes (colonization, immunostimulation, and antimicrobial activity) that could account for their claimed probiotic properties. Three B. cereus strains were shown to persist in the mouse gastrointestinal tract for up to 18 days postadministration, demonstrating that these organisms have some ability to colonize. Spores of one B. cereus strain were extremely sensitive to simulated gastric conditions and simulated intestinal fluids. Spores of all strains were immunogenic when they were given orally to mice, but the B. pumilus strain was found to generate particularly high anti-spore immunoglobulin G titers. Spores of B. pumilus and of a laboratory strain of B. subtilis were found to induce the proinflammatory cytokine interleukin-6 in a cultured macrophage cell line, and in vivo, spores of B. pumilus and B. subtilis induced the proinflammatory cytokine tumor necrosis factor alpha and the Th1 cytokine gamma interferon. The B. pumilus strain and one B. cereus strain (B. cereus var. vietnami) were found to produce a bacteriocin-like activity against other Bacillus species. The results that provided evidence of colonization, immunostimulation, and antimicrobial activity support the hypothesis that the organisms have a potential probiotic effect. However, the three B. cereus strains were also found to produce the Hbl and Nhe enterotoxins, which makes them unsafe for human use. FAU - Duc, Le H AU - Duc le H AD - School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 OEX, United Kingdom. FAU - Hong, Huynh A AU - Hong HA FAU - Barbosa, Teresa M AU - Barbosa TM FAU - Henriques, Adriano O AU - Henriques AO FAU - Cutting, Simon M AU - Cutting SM LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Appl Environ Microbiol JT - Applied and environmental microbiology JID - 7605801 RN - 0 (Enterotoxins) RN - 0 (Interleukin-1) RN - 0 (Interleukin-6) RN - 0 (Tumor Necrosis Factor-alpha) RN - 82115-62-6 (Interferon-gamma) SB - IM MH - Animals MH - *Bacillus/pathogenicity/physiology MH - Bacillus cereus/pathogenicity/physiology MH - Enterotoxins/biosynthesis MH - Female MH - Gastrointestinal Tract/immunology/microbiology MH - Humans MH - Interferon-gamma/biosynthesis MH - Interleukin-1/biosynthesis MH - Interleukin-6/biosynthesis MH - Mice MH - Mice, Inbred C57BL MH - *Probiotics/adverse effects MH - Safety MH - Spores, Bacterial MH - Tumor Necrosis Factor-alpha/biosynthesis MH - Virulence PMC - PMC383048 EDAT- 2004/04/07 05:00 MHDA- 2004/09/03 05:00 PMCR- 2004/04/01 CRDT- 2004/04/07 05:00 PHST- 2004/04/07 05:00 [pubmed] PHST- 2004/09/03 05:00 [medline] PHST- 2004/04/07 05:00 [entrez] PHST- 2004/04/01 00:00 [pmc-release] AID - 1337 [pii] AID - 10.1128/AEM.70.4.2161-2171.2004 [doi] PST - ppublish SO - Appl Environ Microbiol. 2004 Apr;70(4):2161-71. doi: 10.1128/AEM.70.4.2161-2171.2004. PMID- 19626526 OWN - NLM STAT- MEDLINE DCOM- 20090828 LR - 20171116 IS - 1545-9632 (Electronic) IS - 1545-9624 (Linking) VI - 6 IP - 10 DP - 2009 Oct TI - Using ergonomics to enhance safe production at a surface coal mine--a case study with powder crews. PG - D55-62 LID - 10.1080/15459620903146636 [doi] AB - Job tasks that involve exposure to work-related musculoskeletal disorder (WMSD) risk factors may impact both the risk of injury and production downtime. Common WMSD risks factors associated with mining tasks include forceful exertions, awkward postures, repetitive motion, jolting and jarring, forceful gripping, contact stress, and whole body and segmental vibration. Mining environments that expose workers to temperature/humidity extremes, windy conditions, and slippery and uneven walking surfaces also contribute to injury risk. National Institute for Occupational Safety and Health (NIOSH) researchers worked with powder crew members from the Bridger Coal Company to identify and rank routine work tasks based on perceived exposure to WMSD risk factors. This article presents the process followed to identify tasks that workers believed involved the greatest exposure to risk factors and discusses risk reduction strategies. Specifically, the proposed prill truck design changes addressed cab ingress/egress, loading blast holes, and access to the upper deck of the prill truck. FAU - Torma-Krajewski, Janet AU - Torma-Krajewski J AD - Pittsburgh Research Laboratory, National Institute of Occupational Safety and Health, Arvada, Colorado, USA. FAU - Wiehagen, William AU - Wiehagen W FAU - Etcheverry, Ann AU - Etcheverry A FAU - Turin, Fred AU - Turin F FAU - Unger, Richard AU - Unger R LA - eng PT - Journal Article PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - Accidents, Occupational/prevention & control MH - Adult MH - *Coal Mining MH - Ergonomics/*methods MH - Humans MH - Interviews as Topic MH - Musculoskeletal Diseases/*prevention & control MH - Occupational Diseases/*prevention & control MH - Occupational Health MH - Risk Factors MH - Safety/*standards MH - Task Performance and Analysis EDAT- 2009/07/25 09:00 MHDA- 2009/08/29 09:00 CRDT- 2009/07/24 09:00 PHST- 2009/07/24 09:00 [entrez] PHST- 2009/07/25 09:00 [pubmed] PHST- 2009/08/29 09:00 [medline] AID - 913229407 [pii] AID - 10.1080/15459620903146636 [doi] PST - ppublish SO - J Occup Environ Hyg. 2009 Oct;6(10):D55-62. doi: 10.1080/15459620903146636. PMID- 30579159 OWN - NLM STAT- MEDLINE DCOM- 20191217 LR - 20191217 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 170 DP - 2019 Mar TI - The effects of ambient temperatures on the risk of work-related injuries and illnesses: Evidence from Adelaide, Australia 2003-2013. PG - 101-109 LID - S0013-9351(18)30653-4 [pii] LID - 10.1016/j.envres.2018.12.024 [doi] AB - BACKGROUND: The thermal environment can directly affect workers' occupational health and safety, and act as a contributing factor to injury or illness. However, the literature addressing risks posed by varying temperatures on work-related injuries and illnesses is limited. OBJECTIVES: To examine the occupational injury and illness risk profiles for hot and cold conditions. METHODS: Daily numbers of workers' compensation claims in Adelaide, South Australia from 2003 to 2013 (n = 224,631) were sourced together with daily weather data. The impacts of maximum daily temperature on the risk of work-related injuries and illnesses was assessed using a time-stratified case-crossover study design combined with a distributed lag non-linear model. RESULTS: The minimum number of workers' compensation claims occurred when the maximum daily temperature was 25 °C. Compared with this optimal temperature, extremely hot temperatures (99th percentile) were associated with an increase in overall claims (RR: 1.30, 95%CI: 1.18-1.44) whereas a non-significant increase was observed with extremely cold temperatures (1st percentile, RR: 1.10 (95%CI: 0.99-1.21). Heat exposure had an acute effect on workers' injuries whereas cold conditions resulted in delayed effects. Moderate temperatures were associated with a greater injury burden than extreme temperatures. CONCLUSION: Days of very high temperatures were associated with the greatest risks of occupational injuries; whereas moderate temperatures, which occur more commonly, have the greatest burden. These findings suggest that the broader range of thermal conditions should be considered in workplace injury and illness prevention strategies. CI - Copyright © 2018 Elsevier Inc. All rights reserved. FAU - Varghese, Blesson M AU - Varghese BM AD - School of Public Health, The University of Adelaide, Adelaide, Australia. FAU - Barnett, Adrian G AU - Barnett AG AD - School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. FAU - Hansen, Alana L AU - Hansen AL AD - School of Public Health, The University of Adelaide, Adelaide, Australia. FAU - Bi, Peng AU - Bi P AD - School of Public Health, The University of Adelaide, Adelaide, Australia. FAU - Hanson-Easey, Scott AU - Hanson-Easey S AD - School of Public Health, The University of Adelaide, Adelaide, Australia. FAU - Heyworth, Jane S AU - Heyworth JS AD - School of Population and Global Health, The University of Western Australia, Crawley, Australia. FAU - Sim, Malcolm R AU - Sim MR AD - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, The Alfred Centre, Monash University, Melbourne, VIC, Australia. FAU - Pisaniello, Dino L AU - Pisaniello DL AD - School of Public Health, The University of Adelaide, Adelaide, Australia. Electronic address: dino.pisaniello@adelaide.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20181213 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 SB - IM MH - Australia/epidemiology MH - Cold Temperature MH - Cross-Over Studies MH - Hot Temperature MH - Humans MH - Occupational Exposure/*statistics & numerical data MH - Occupational Injuries/*epidemiology MH - South Australia MH - *Temperature OTO - NOTNLM OT - Attributable risk OT - Case-crossover design OT - Distributed lag non-linear model OT - Injuries OT - Occupational Health OT - Temperature EDAT- 2018/12/24 06:00 MHDA- 2019/12/18 06:00 CRDT- 2018/12/23 06:00 PHST- 2018/08/06 00:00 [received] PHST- 2018/12/11 00:00 [revised] PHST- 2018/12/12 00:00 [accepted] PHST- 2018/12/24 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2018/12/23 06:00 [entrez] AID - S0013-9351(18)30653-4 [pii] AID - 10.1016/j.envres.2018.12.024 [doi] PST - ppublish SO - Environ Res. 2019 Mar;170:101-109. doi: 10.1016/j.envres.2018.12.024. Epub 2018 Dec 13. PMID- 28169913 OWN - NLM STAT- MEDLINE DCOM- 20180417 LR - 20191210 IS - 1530-0374 (Electronic) IS - 1072-3714 (Linking) VI - 24 IP - 7 DP - 2017 Jul TI - Use of a novel fractional CO2 laser for the treatment of genitourinary syndrome of menopause: 1-year outcomes. PG - 810-814 LID - 10.1097/GME.0000000000000839 [doi] AB - OBJECTIVES: To assess safety and efficacy of a fractional CO2 laser therapy for the treatment of genitourinary syndrome of menopause (GSM) with follow-up to 1 year posttreatment. METHODS: Women presenting with GSM and meeting inclusion criterion were enrolled. Visual Analog Scales were used to grade vaginal pain, burning, itching, dryness, dyspareunia, and dysuria. Dilators were used to rate vaginal elasticity at baseline and at each follow-up visit. Before each treatment and at follow-up, Vaginal Health Index scoring and Female Sexual Function Index questionnaires were completed. Women received three vaginal laser treatments spaced 6 weeks apart. Participant satisfaction was measured on 5-point Likert scales (1 = very dissatisfied, 5 = very satisfied). RESULTS: Of 30 women (mean age 58.6 ± 8.8 years), three were lost to follow-up at 3 months and six at 1 year. None were discontinued or withdrew due to an adverse event. Average improvement in Visual Analog Scale scores for all symptom categories was statistically significant at 3 months and remained so through 1 year, except dysuria. Differences between data at 3 months and 1 year were not statistically significant, indicating persistence of positive outcomes. Average overall improvement in pain was 1.9 (±3.4), burning 1.9 (±3.1), itching 1.4 (±1.9), dryness 5.9 (±2.8), dyspareunia 4.9 (±3.3), and dysuria 0.9 (±3.1). Improvement in average Vaginal Health Index and Female Sexual Function Index scores was also statistically significant (P < 0.0001). Of 19 women undergoing dilator examination at 1 year, 18 (94.8%) were comfortable with the same or larger dilator size. Twenty-two of 24 women (92%) were satisfied or extremely satisfied with the treatment at 1 year. CONCLUSIONS: Based on study data up to 1 year, the fractional CO2 laser may be an effective and safe treatment for women suffering from symptoms of GSM, although additional studies with larger populations and placebo control is needed to confirm these results. FAU - Sokol, Eric R AU - Sokol ER AD - 1Urogynecology and Pelvic Reconstructive Surgery, Stanford University, Stanford, CA 2Advanced Urogynecology and Pelvic Surgery, The Christ Hospital, Cincinnati, OH. FAU - Karram, Mickey M AU - Karram MM LA - eng PT - Evaluation Study PT - Journal Article PL - United States TA - Menopause JT - Menopause (New York, N.Y.) JID - 9433353 SB - IM CIN - Menopause. 2018 Feb;25(2):242. doi: 10.1097/GME.0000000000001034. PMID: 29206772 CIN - Menopause. 2018 Feb;25(2):243-244. doi: 10.1097/GME.0000000000001035. PMID: 29342027 MH - Aged MH - Dyspareunia/etiology/pathology/surgery MH - Dysuria/etiology/pathology/surgery MH - Female MH - Female Urogenital Diseases/etiology/pathology/*surgery MH - Follow-Up Studies MH - Humans MH - Lasers, Gas/*therapeutic use MH - *Menopause MH - Middle Aged MH - Pain Measurement MH - Syndrome MH - Treatment Outcome MH - Vagina/pathology/surgery MH - Vaginal Diseases/etiology/pathology/surgery EDAT- 2017/02/09 06:00 MHDA- 2018/04/18 06:00 CRDT- 2017/02/08 06:00 PHST- 2017/02/09 06:00 [pubmed] PHST- 2018/04/18 06:00 [medline] PHST- 2017/02/08 06:00 [entrez] AID - 10.1097/GME.0000000000000839 [doi] PST - ppublish SO - Menopause. 2017 Jul;24(7):810-814. doi: 10.1097/GME.0000000000000839. PMID- 31080232 OWN - NLM STAT- MEDLINE DCOM- 20200720 LR - 20200720 IS - 1897-9483 (Electronic) IS - 0032-3772 (Linking) VI - 129 IP - 7-8 DP - 2019 Aug 29 TI - Gastroesophageal reflux disease and Barrett esophagus: an overview of evidence-based guidelines. PG - 516-525 LID - 10.20452/pamw.14828 [doi] AB - Gastroesophageal reflux disease is an extremely common condition worldwide, with the published prevalence rates varying from 2.5% in China to 51.2% in Greece. Its economic and morbidity burden is vast, and optimizing care for this condition carries huge financial and patient‑related benefits. The disease can be complicated by progression to Barrett esophagus (BE), a precancerous condition that affects approximately 2% of the population and remains undiagnosed in many individuals. The National Institute of Clinical Excellence has produced guidelines on cost‑effective management of gastroesophageal reflux disease in patients in the United Kingdom, and the Benign Barrett's and Cancer Taskforce consensus was the largest international review of evidence known on the management of benign BE complications. This paper is a review of these guidelines with updates on new evidence. Areas for future development involve risk‑stratifying patients to surveillance, chemoprevention agents, and genetic biomarkers to help decide who will be at highest risk of malignant progression. Evidence supports the safety of proton pump inhibitors for symptom control in the medium term (ie, 9 years) and reducing the risk of progression of BE, while surgical options are cost‑effective treatments for certain patients. Barrett esophagus surveillance should be directed towards high‑risk groups, while those at lower risk may benefit from chemoprevention strategies. FAU - Ratcliffe, Elizabeth G AU - Ratcliffe EG AD - Endoscopy Unit, Wrightington, Wigan and Leigh NHS Trust, Leigh, United Kingdom FAU - Jankowski, Janusz A AU - Jankowski JA AD - Sherwood Forest Hospitals NHS Trust, Sutton in Ashfield, United Kingdom AD - National Institute for Health and Care Excellence, London, United Kingdom AD - University of Liverpool, Liverpool, United Kingdom LA - eng PT - Journal Article DEP - 20190513 PL - Poland TA - Pol Arch Intern Med JT - Polish archives of internal medicine JID - 101700960 RN - 0 (Proton Pumps) SB - IM EIN - Pol Arch Intern Med. 2020 Jan 31;130(1):98-99. doi: 10.20452/pamw.15171. PMID: 32011607 MH - Barrett Esophagus/complications/etiology/*therapy MH - Disease Progression MH - Gastroesophageal Reflux/*complications/therapy MH - Humans MH - Practice Guidelines as Topic MH - Precancerous Conditions/etiology/prevention & control/*therapy MH - Primary Prevention/*methods MH - Proton Pumps/therapeutic use MH - Risk Factors MH - United Kingdom EDAT- 2019/05/14 06:00 MHDA- 2020/07/21 06:00 CRDT- 2019/05/14 06:00 PHST- 2019/05/14 06:00 [pubmed] PHST- 2020/07/21 06:00 [medline] PHST- 2019/05/14 06:00 [entrez] AID - 10.20452/pamw.14828 [doi] PST - ppublish SO - Pol Arch Intern Med. 2019 Aug 29;129(7-8):516-525. doi: 10.20452/pamw.14828. Epub 2019 May 13. PMID- 26625582 OWN - NLM STAT- MEDLINE DCOM- 20160201 LR - 20151202 IS - 0746-1739 (Print) IS - 0746-1739 (Linking) VI - 33 IP - 5 DP - 2015 Sep-Oct TI - High Reliability and Excellence in Staffing. PG - 283-4 AB - Nurse staffing is a complex issue, with many facets and no one right answer. High-reliability organizations (HROs) strive and succeed in achieving a high degree of safety or reliability despite operating in hazardous conditions. HROs have systems in place that make them extremely consistent in accomplishing their goals and avoiding potential errors. However, the inability to resolve quality issues may very well be related to the lack of adoption of high-reliability principles throughout our organizations. FAU - Mensik, Jennifer AU - Mensik J LA - eng PT - Journal Article PL - United States TA - Nurs Econ JT - Nursing economic$ JID - 8404213 MH - Cooperative Behavior MH - Efficiency, Organizational MH - Humans MH - Nursing Staff/*standards MH - Organizational Culture MH - *Personnel Staffing and Scheduling MH - *Quality Improvement MH - Safety Management/*methods MH - United States EDAT- 2015/12/03 06:00 MHDA- 2016/02/02 06:00 CRDT- 2015/12/03 06:00 PHST- 2015/12/03 06:00 [entrez] PHST- 2015/12/03 06:00 [pubmed] PHST- 2016/02/02 06:00 [medline] PST - ppublish SO - Nurs Econ. 2015 Sep-Oct;33(5):283-4. PMID- 17995566 OWN - NLM STAT- MEDLINE DCOM- 20080122 LR - 20211020 IS - 0017-9124 (Print) IS - 1475-6773 (Electronic) IS - 0017-9124 (Linking) VI - 42 IP - 6 Pt 1 DP - 2007 Dec TI - Pediatric patient safety events during hospitalization: approaches to accounting for institution-level effects. PG - 2275-93; discussion 2294-323 AB - OBJECTIVE: To determine the rates, patient, and institutional characteristics associated with the occurrence of patient safety indicators (PSIs) in hospitalized children and the degree of statistical difference derived from using three approaches of controlling for institution level effects. DATA SOURCE: Pediatric Health Information System Dataset consisting of all pediatric discharges (<21 years of age) from 34 academic, freestanding children's hospitals for calendar year 2003. METHODS: The rates of PSIs were computed for all discharges. The patient and institutional characteristics associated with these PSIs were calculated. The analyses sequentially applied three increasingly conservative methods to control for the institution-level effects robust standard error estimation, a fixed effects model, and a random effects model. The degree of difference from a "base state," which excluded institution-level variables, and between the models was calculated. The effects of these analyses on the interpretation of the PSIs are presented. PRINCIPAL FINDINGS: PSIs are relatively infrequent events in hospitalized children ranging from 0 per 10,000 (postoperative hip fracture) to 87 per 10,000 (postoperative respiratory failure). Significant variables associated PSIs included age (neonates), race (Caucasians), payor status (public insurance), severity of illness (extreme), and hospital size (>300 beds), which all had higher rates of PSIs than their reference groups in the bivariable logistic regression results. The three different approaches of adjusting for institution-level effects demonstrated that there were similarities in both the clinical and statistical significance across each of the models. CONCLUSIONS: Institution-level effects can be appropriately controlled for by using a variety of methods in the analyses of administrative data. Whenever possible, resource-conservative methods should be used in the analyses especially if clinical implications are minimal. FAU - Slonim, Anthony D AU - Slonim AD AD - Center for Clinical Effectiveness, The George Washington University School of Medicine, 111 Michigan Avenue, NW, Suite 3-100, Washington, DC, USA. FAU - Marcin, James P AU - Marcin JP FAU - Turenne, Wendy AU - Turenne W FAU - Hall, Matt AU - Hall M FAU - Joseph, Jill G AU - Joseph JG LA - eng GR - K08 HS013179/HS/AHRQ HHS/United States GR - K08 HS014009/HS/AHRQ HHS/United States GR - K08 HS 14009-01/HS/AHRQ HHS/United States GR - K08 HS 13179-01/HS/AHRQ HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Health Serv Res JT - Health services research JID - 0053006 SB - IM MH - Adolescent MH - Child MH - Child, Hospitalized/*statistics & numerical data MH - Child, Preschool MH - Databases as Topic MH - Female MH - Health Services Research/methods MH - Hospitals, Pediatric/organization & administration/*standards/statistics & numerical data MH - Humans MH - Iatrogenic Disease/*epidemiology/prevention & control MH - Incidence MH - Infant MH - Infant, Newborn MH - Institutional Practice MH - Male MH - Medical Errors/prevention & control/*statistics & numerical data MH - Models, Statistical MH - Risk Factors MH - Safety Management/*statistics & numerical data MH - United States/epidemiology PMC - PMC2151391 EDAT- 2007/11/13 09:00 MHDA- 2008/01/23 09:00 PMCR- 2009/12/01 CRDT- 2007/11/13 09:00 PHST- 2007/11/13 09:00 [pubmed] PHST- 2008/01/23 09:00 [medline] PHST- 2007/11/13 09:00 [entrez] PHST- 2009/12/01 00:00 [pmc-release] AID - HESR729 [pii] AID - 10.1111/j.1475-6773.2007.00729.x [doi] PST - ppublish SO - Health Serv Res. 2007 Dec;42(6 Pt 1):2275-93; discussion 2294-323. doi: 10.1111/j.1475-6773.2007.00729.x. PMID- 28089898 OWN - NLM STAT- MEDLINE DCOM- 20170816 LR - 20220330 IS - 1532-821X (Electronic) IS - 0003-9993 (Linking) VI - 98 IP - 8 DP - 2017 Aug TI - Exercise Guidelines to Promote Cardiometabolic Health in Spinal Cord Injured Humans: Time to Raise the Intensity? PG - 1693-1704 LID - S0003-9993(17)30004-7 [pii] LID - 10.1016/j.apmr.2016.12.008 [doi] AB - Spinal cord injury (SCI) is a life-changing event that, as a result of paralysis, negatively influences habitual levels of physical activity and hence cardiometabolic health. Performing regular structured exercise therefore appears extremely important in persons with SCI. However, exercise options are mainly limited to the upper body, which involves a smaller activated muscle mass compared with the mainly leg-based activities commonly performed by nondisabled individuals. Current exercise guidelines for SCI focus predominantly on relative short durations of moderate-intensity aerobic upper-body exercise, yet contemporary evidence suggests this is not sufficient to induce meaningful improvements in risk factors for the prevention of cardiometabolic disease in this population. As such, these guidelines and their physiological basis require reappraisal. In this special communication, we propose that high-intensity interval training (HIIT) may be a viable alternative exercise strategy to promote vigorous-intensity exercise and prevent cardiometabolic disease in persons with SCI. Supplementing the limited data from SCI cohorts with consistent findings from studies in nondisabled populations, we present strong evidence to suggest that HIIT is superior to moderate-intensity aerobic exercise for improving cardiorespiratory fitness, insulin sensitivity, and vascular function. The potential application and safety of HIIT in this population is also discussed. We conclude that increasing exercise intensity could offer a simple, readily available, time-efficient solution to improve cardiometabolic health in persons with SCI. We call for high-quality randomized controlled trials to examine the efficacy and safety of HIIT in this population. CI - Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved. FAU - Nightingale, Tom E AU - Nightingale TE AD - Department for Health, University of Bath, Bath, United Kingdom. FAU - Metcalfe, Richard S AU - Metcalfe RS AD - Sport and Exercise Sciences Research Institute, Ulster University, County Antrim, Northern Ireland. FAU - Vollaard, Niels B AU - Vollaard NB AD - Department for Health, University of Bath, Bath, United Kingdom; Faculty of Health Sciences and Sport, University of Stirling, Stirling, Scotland. FAU - Bilzon, James L AU - Bilzon JL AD - Department for Health, University of Bath, Bath, United Kingdom. Electronic address: J.Bilzon@Bath.ac.uk. LA - eng PT - Journal Article DEP - 20170113 PL - United States TA - Arch Phys Med Rehabil JT - Archives of physical medicine and rehabilitation JID - 2985158R RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Blood Glucose MH - Blood Pressure MH - Body Composition MH - Cardiorespiratory Fitness/physiology MH - Dyslipidemias/metabolism MH - Exercise/*physiology MH - Humans MH - Insulin/metabolism MH - Patient Safety MH - Physical Fitness/*physiology MH - Practice Guidelines as Topic MH - Risk Factors MH - Spinal Cord Injuries/*physiopathology OTO - NOTNLM OT - Cardiorespiratory fitness OT - Cardiovascular diseases OT - Exercise OT - High-intensity interval training OT - Metabolic diseases OT - Rehabilitation OT - Spinal cord injuries EDAT- 2017/01/17 06:00 MHDA- 2017/08/17 06:00 CRDT- 2017/01/17 06:00 PHST- 2016/11/04 00:00 [received] PHST- 2016/12/15 00:00 [accepted] PHST- 2017/01/17 06:00 [pubmed] PHST- 2017/08/17 06:00 [medline] PHST- 2017/01/17 06:00 [entrez] AID - S0003-9993(17)30004-7 [pii] AID - 10.1016/j.apmr.2016.12.008 [doi] PST - ppublish SO - Arch Phys Med Rehabil. 2017 Aug;98(8):1693-1704. doi: 10.1016/j.apmr.2016.12.008. Epub 2017 Jan 13. PMID- 35422120 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220428 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 14 IP - 16 DP - 2022 Apr 27 TI - Probing the Role of Multi-scale Heterogeneity in Graphite Electrodes for Extreme Fast Charging. PG - 18335-18352 LID - 10.1021/acsami.1c25214 [doi] AB - Electrode-scale heterogeneity can combine with complex electrochemical interactions to impede lithium-ion battery performance, particularly during fast charging. This study investigates the influence of electrode heterogeneity at different scales on the lithium-ion battery electrochemical performance under operational extremes. We employ image-based mesoscale simulation in conjunction with a three-dimensional electrochemical model to predict performance variability in 14 graphite electrode X-ray computed tomography data sets. Our analysis reveals that the tortuous anisotropy stemming from the variable particle morphology has a dominating influence on the overall cell performance. Cells with platelet morphology achieve lower capacity, higher heat generation rates, and severe plating under extreme fast charge conditions. On the contrary, the heterogeneity due to the active material clustering alone has minimal impact. Our work suggests that manufacturing electrodes with more homogeneous and isotropic particle morphology will improve electrochemical performance and improve safety, enabling electromobility. FAU - Parmananda, Mukul AU - Parmananda M AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Norris, Chance AU - Norris C AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. FAU - Roberts, Scott A AU - Roberts SA AUID- ORCID: 0000-0002-4196-6771 AD - Engineering Sciences Center, Sandia National Laboratories, Albuquerque, New Mexico 87185, United States. FAU - Mukherjee, Partha P AU - Mukherjee PP AUID- ORCID: 0000-0001-7900-7261 AD - School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States. LA - eng PT - Journal Article DEP - 20220414 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - electrode heterogeneity OT - fast charging OT - graphite electrodes OT - image-based modeling OT - lithium plating EDAT- 2022/04/16 06:00 MHDA- 2022/04/16 06:01 CRDT- 2022/04/15 05:19 PHST- 2022/04/16 06:00 [pubmed] PHST- 2022/04/16 06:01 [medline] PHST- 2022/04/15 05:19 [entrez] AID - 10.1021/acsami.1c25214 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2022 Apr 27;14(16):18335-18352. doi: 10.1021/acsami.1c25214. Epub 2022 Apr 14. PMID- 17658113 OWN - NLM STAT- MEDLINE DCOM- 20071029 LR - 20171116 IS - 1120-9135 (Print) IS - 1120-9135 (Linking) VI - 19 IP - 3 DP - 2007 May-Jun TI - Road safety and the tsunami of cell phones. PG - 269-74 AB - In the last years an extremely rapid massive diffusion of the cell phones is occurred. Currently in Italy, as in many other countries, almost all the youngsters and a lot of adults possess a cell phones. This device is enormously useful, but its use can determine negative effects on the user's attention, i.e. during vehicle driving. Numerous epidemiological studies show that cell phone use in driving determines a relative risk of causing a road accident around 4 (equivalent to driving with 0.8 g/l blood alcohol concentration), for both hands-held and hands-free devices. This risk doesn't seem well perceived from the Italian drivers: as our surveys show, the 2.5% of them use a cellular hands-held while driving. This situation appears to evolve toward more critical conditions, given the quick diffusion of ever more technologically advanced instruments, such as video-cell phones, mostly capable of capturing the attention, or TV-cell phones, with which the distracting occasions could be more frequent and prolonged. The use of the cell phone seems to imply an important risk for pedestrians: the first results of the monitoring results that we are producing on this matter in Rome show that the 5.5% of the pedestrians cross the road while talking with a hands-held cell phones, in the most of cases ignoring the traffic conditions at all. All this facts show the urgency to promote specific actions of prevention, in absence of which it is reasonable to foresee a consistent growth in the number of road traffic accidents. In our opinion it is necessary to capillarily inform the public of the signalled risks, possibly also in the advertising spaces of the producers and managers of the cellular telephony, apart obvious repressive actions on the use of the cell phones during the guide of a vehicle. FAU - Taggi, F AU - Taggi F AD - Dept. Environment and Prevention, Section Environment and Trauma, National Institute of Health, Rome, Italy. taggi@iss.it FAU - Crenca, A AU - Crenca A FAU - Cedri, C AU - Cedri C FAU - Giustini, M AU - Giustini M FAU - Dosi, G AU - Dosi G FAU - Marturano, P AU - Marturano P LA - eng PT - Journal Article PL - Italy TA - Ann Ig JT - Annali di igiene : medicina preventiva e di comunita JID - 9002865 SB - IM MH - Adolescent MH - Adult MH - *Automobile Driving MH - Cell Phone/*statistics & numerical data MH - Female MH - Humans MH - Male MH - Risk Factors MH - *Safety EDAT- 2007/07/31 09:00 MHDA- 2007/10/30 09:00 CRDT- 2007/07/31 09:00 PHST- 2007/07/31 09:00 [pubmed] PHST- 2007/10/30 09:00 [medline] PHST- 2007/07/31 09:00 [entrez] PST - ppublish SO - Ann Ig. 2007 May-Jun;19(3):269-74. PMID- 17894208 OWN - NLM STAT- MEDLINE DCOM- 20071101 LR - 20191026 IS - 1049-023X (Print) IS - 1049-023X (Linking) VI - 22 IP - 3 DP - 2007 May-Jun TI - Factors associated with high-rise evacuation: qualitative results from the World Trade Center Evacuation Study. PG - 165-73 AB - INTRODUCTION: Due to the fact that most high-rise structures (i.e., >75 feet high, or eight to ten stories) are constructed with extensive and redundant fire safety features, current fire safety procedures typically only involve limited evacuation during minor to moderate fire emergencies. Therefore, full-scale evacuation of high-rise buildings is highly unusual and consequently, little is known about how readily and rapidly high-rise structures can be evacuated fully. Factors that either facilitate or inhibit the evacuation process remain under-studied. OBJECTIVE: This paper presents results from the qualitative phase of the World Trade Center Evacuation Study, a three-year, five-phase study designed to improve our understanding of the individual, organizational, and environmental factors that helped or hindered evacuation from the World Trade Center (WTC) Towers 1 and 2, on 11 September 2001. METHODS: Qualitative data from semi-structured, in-depth interviews and focus groups involving WTC evacuees were collected and analyzed. RESULTS: On the individual level, factors that affected evacuation included perception of risk (formed largely by sensory cues), preparedness training, degree of familiarity with the building, physical condition, health status, and footwear. Individual behavior also was affected by group behavior and leadership. At the organizational level, evacuation was affected by worksite preparedness planning, including the training and education of building occupants, and risk communication. The environmental conditions affecting evacuation included smoke, flames, debris, general condition and degree of crowdedness on staircases, and communication infrastructure systems (e.g., public address, landline, cellular and fire warden's telephones). CONCLUSIONS: Various factors at the individual, organizational, and environmental levels were identified that affected evacuation. Interventions that address the barriers to evacuation may improve the full-scale evacuation of other high-rise buildings under extreme conditions. Further studies should focus on the development and evaluation of targeted interventions, including model emergency preparedness planning for high-rise occupancies. FAU - Gershon, Robyn R M AU - Gershon RR AD - Department of Sociomedical Sciences, Columbia University Mailman School of Public Health, New York City, New York 10032, USA. rg405@columbia.edu FAU - Qureshi, Kristine A AU - Qureshi KA FAU - Rubin, Marcie S AU - Rubin MS FAU - Raveis, Victoria H AU - Raveis VH LA - eng GR - U36/CCU300430-22/CC/ODCDC CDC HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Prehosp Disaster Med JT - Prehospital and disaster medicine JID - 8918173 MH - Communication MH - Disaster Planning/*methods/standards MH - Explosions MH - Facility Design and Construction MH - Fires MH - Follow-Up Studies MH - Humans MH - Interviews as Topic MH - New York City MH - Qualitative Research MH - Rescue Work/*methods MH - Safety Management/*methods MH - September 11 Terrorist Attacks/*statistics & numerical data EDAT- 2007/09/27 09:00 MHDA- 2007/11/02 09:00 CRDT- 2007/09/27 09:00 PHST- 2007/09/27 09:00 [pubmed] PHST- 2007/11/02 09:00 [medline] PHST- 2007/09/27 09:00 [entrez] AID - 10.1017/s1049023x0000460x [doi] PST - ppublish SO - Prehosp Disaster Med. 2007 May-Jun;22(3):165-73. doi: 10.1017/s1049023x0000460x. PMID- 31248266 OWN - NLM STAT- MEDLINE DCOM- 20210524 LR - 20240730 IS - 1555-824X (Electronic) IS - 1062-8606 (Print) IS - 1062-8606 (Linking) VI - 35 IP - 3 DP - 2020 May/Jun TI - Problematic Risk Adjustment in National Healthcare Safety Network Measures. PG - 205-212 LID - 10.1177/1062860619859073 [doi] AB - This article reviews the risk-adjustment models underpinning the National Healthcare Safety Network (NHSN) standardized infection ratios. After first describing the models, the authors focus on hospital intensive care unit (ICU) designation as a variable employed across the various risk models. The risk-adjusted frequency with which ICU services are reported in Medicare fee-for-service claims data was compared as a proxy for determining whether reporting of ICU days is similar across hospitals. Extreme variation was found in the reporting of ICU utilization among admissions for congestive heart failure, ranging from 25% in the lowest admission hospital quartile to 95% in the highest. The across-hospital variation in reported ICU utilization was found to be unrelated to patient severity. Given that such extreme variation appears in a designation of ICU versus non-ICU utilization, the NHSN risk-adjustment models' dependence on nursing unit designation should be a cause for concern. FAU - Fuller, Richard L AU - Fuller RL AUID- ORCID: 0000-0002-1270-3198 AD - 3M Health Information Systems, Silver Spring, MD. FAU - Hughes, John S AU - Hughes JS AD - Yale University School of Medicine, New Haven, CT. FAU - Atkinson, Graham AU - Atkinson G AUID- ORCID: 0000-0002-6197-5739 AD - J K T G Foundation, Washington, DC. FAU - Aubry, Barbara S AU - Aubry BS AD - 3M Health Information Systems, Salt Lake City, UT. LA - eng GR - UL1 TR001863/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20190627 PL - Netherlands TA - Am J Med Qual JT - American journal of medical quality : the official journal of the American College of Medical Quality JID - 9300756 SB - IM MH - Benchmarking MH - Cross Infection/*prevention & control MH - Fee-for-Service Plans MH - Hospital Bed Capacity MH - Humans MH - Intensive Care Units/*organization & administration/standards MH - Medicare/*organization & administration/standards MH - Quality Indicators, Health Care MH - Risk Adjustment/*organization & administration/standards MH - United States PMC - PMC7281913 OTO - NOTNLM OT - CAUTI OT - CLABSI OT - Hospital-Acquired Condition Reduction Program OT - National Healthcare Safety Network OT - value-based purchasing COIS- Declaration of Conflicting Interests: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Mr Fuller, Dr Hughes, and Ms Aubry report a potential conflict of interest through receiving payment from employment with 3M Health Information Systems, a developer of Potentially Preventable Complications (PPC) software used to measure hospital acquired complication rates. Dr Atkinson reports no conflict of interest. EDAT- 2019/06/30 06:00 MHDA- 2021/05/25 06:00 PMCR- 2020/06/09 CRDT- 2019/06/29 06:00 PHST- 2019/06/30 06:00 [pubmed] PHST- 2021/05/25 06:00 [medline] PHST- 2019/06/29 06:00 [entrez] PHST- 2020/06/09 00:00 [pmc-release] AID - 10.1177_1062860619859073 [pii] AID - 10.1177/1062860619859073 [doi] PST - ppublish SO - Am J Med Qual. 2020 May/Jun;35(3):205-212. doi: 10.1177/1062860619859073. Epub 2019 Jun 27. PMID- 7989055 OWN - NLM STAT- MEDLINE DCOM- 19950109 LR - 20220318 IS - 0018-7208 (Print) IS - 0018-7208 (Linking) VI - 36 IP - 3 DP - 1994 Sep TI - Influencing of warning label signal words on perceived hazard level. PG - 547-56 AB - This experiment investigated the influence of warnings, signal words, and a signal icon on perceived hazard of consumer products. Under the guise of a marketing research study, 135 people (high school students, college students, and participants from a shopping mall) rated product labels on six dimensions, including how hazardous they perceived the products to be. A total of 16 labels from actual household products were used: 9 carried the experimental conditions, and 7 were filler product labels that never carried a warning. Five conditions presented the signal words NOTE, CAUTION, WARNING, DANGER, and LETHAL together with a brief warning message. In another two conditions, a signal icon (exclamation point surrounded by a triangle) was presented together with the terms DANGER and LETHAL. In the final two conditions, one lacked a signal word but retained the warning message, and the other lacked both the warning message and the signal word. Results showed that the presence of a signal word increased perceived product hazard compared with its absence. Significant differences were noted between extreme terms (e.g., NOTE and DANGER) but not between terms usually recommended in warning design guidelines (e.g., CAUTION and WARNING). The signal icon showed no significant effect on hazard perception. Implications of the results and the value of the methodology for future warnings investigations are discussed. FAU - Wogalter, M S AU - Wogalter MS AD - Psychology Department, North Carolina State University, Raleigh 27695. FAU - Jarrard, S W AU - Jarrard SW FAU - Simpson, S N AU - Simpson SN LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - *Attention MH - Female MH - Humans MH - Male MH - Middle Aged MH - Psychophysics MH - *Reading MH - *Safety Management EDAT- 1994/09/01 00:00 MHDA- 1994/09/01 00:01 CRDT- 1994/09/01 00:00 PHST- 1994/09/01 00:00 [pubmed] PHST- 1994/09/01 00:01 [medline] PHST- 1994/09/01 00:00 [entrez] AID - 10.1177/001872089403600310 [doi] PST - ppublish SO - Hum Factors. 1994 Sep;36(3):547-56. doi: 10.1177/001872089403600310. PMID- 31365047 OWN - NLM STAT- MEDLINE DCOM- 20200716 LR - 20210110 IS - 2168-6262 (Electronic) IS - 2168-6254 (Print) IS - 2168-6254 (Linking) VI - 154 IP - 9 DP - 2019 Sep 1 TI - Association of US News & World Report Top Ranking for Gastroenterology and Gastrointestinal Operation With Patient Outcomes in Abdominal Procedures. PG - 861-866 LID - 10.1001/jamasurg.2019.2327 [doi] AB - IMPORTANCE: The US News & World Report (USNWR) annual ranking of the best hospitals for gastroenterology and gastrointestinal operations provides guidance and referral of care for medical and surgical gastrointestinal conditions. OBJECTIVE: To investigate whether USNWR top-ranked hospitals for gastroenterology and gastrointestinal surgical procedures are associated with improvements in patient outcomes, compared with nonranked hospitals, in common advanced laparoscopic abdominal operations. DESIGN, SETTING, AND PARTICIPANTS: This study used the Vizient database, which contains administrative, clinical, and financial inpatient information of index hospitalizations for US academic centers and their affiliated hospitals that are members of Vizient. Data were obtained on advanced laparoscopic abdominal operations performed from January 1, 2017, through December 31, 2017, at USNWR top-ranked hospitals (n = 16 296 operations) and nonranked hospitals (n = 35 573 operations). Abdominal operations included bariatric, colorectal, and hiatal hernia procedures. Operations on patients younger than 18 years, emergent cases, conversion cases, and patients with extreme severity of illness were excluded. MAIN OUTCOMES AND MEASURES: Outcome measures included in-hospital mortality, mortality index (observed to expected mortality ratio), serious morbidity, length of stay, and cost. RESULTS: A total of 51 869 advanced laparoscopic abdominal operations were performed at 351 academic health centers and their community affiliates. Of these procedures, 16 296 (31.4%) were performed at 41 top-ranked hospitals and 35 573 (68.6%) at 310 nonranked hospitals. The annual case volume at top-ranked hospitals was 397 compared with 114 at nonranked hospitals. Between top-ranked and nonranked hospitals, no significant differences were found in in-hospital mortality (0.04% vs 0.07%; P = .33) or serious morbidity (1.06% vs 1.02%; P = .75). Compared with nonranked hospitals, advanced laparoscopic abdominal operations performed at top-ranked hospitals had higher mean costs ($7128 [$4917] vs $7742 [$6787]; P < .01) and longer mean lengths of stay (2.38 [2.60] days vs 2.73 [3.31] days; P < .01). CONCLUSIONS AND RELEVANCE: Although, among academic centers, the annual volume of advanced laparoscopic abdominal operations was 3-fold higher for USNWR top-ranked hospitals compared with nonranked hospitals, the volume did not appear to be associated with improved patient outcomes. FAU - Gambhir, Sahil AU - Gambhir S AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Daly, Shaun AU - Daly S AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Grigorian, Areg AU - Grigorian A AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Sujtha-Bhaskar, Sarath AU - Sujtha-Bhaskar S AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Inaba, Colette S AU - Inaba CS AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Hinojosa, Marcelo W AU - Hinojosa MW AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Smith, Brian R AU - Smith BR AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. FAU - Nguyen, Ninh T AU - Nguyen NT AD - Department of Surgery, University of California Irvine Medical Center, Orange, California. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - JAMA Surg JT - JAMA surgery JID - 101589553 SB - IM CIN - JAMA Surg. 2019 Sep 1;154(9):867. doi: 10.1001/jamasurg.2019.2328. PMID: 31365036 MH - Academic Medical Centers MH - Bariatric Surgery/*methods/statistics & numerical data MH - Databases, Factual MH - Delivery of Health Care MH - Digestive System Surgical Procedures/*methods/statistics & numerical data MH - Female MH - Gastroenterology/*standards/trends MH - Hospital Mortality/trends MH - Humans MH - Laparoscopy/*methods/statistics & numerical data MH - Male MH - Newspapers as Topic MH - *Outcome Assessment, Health Care MH - Patient Safety MH - Survival Analysis MH - Tertiary Care Centers MH - Treatment Outcome MH - United States PMC - PMC6669785 COIS- Conflict of Interest Disclosures: Dr Nguyen reported honorarium as a speaker for Covidien, Gore, Novadaq, and Olympus outside of the submitted work. Dr Smith reported honorarium as an educational consultant for Stryker Endoscopy outside of the submitted work. No other disclosures were reported. EDAT- 2019/08/01 06:00 MHDA- 2020/07/17 06:00 PMCR- 2020/07/31 CRDT- 2019/08/01 06:00 PHST- 2019/08/01 06:00 [pubmed] PHST- 2020/07/17 06:00 [medline] PHST- 2019/08/01 06:00 [entrez] PHST- 2020/07/31 00:00 [pmc-release] AID - 2738657 [pii] AID - soi190043 [pii] AID - 10.1001/jamasurg.2019.2327 [doi] PST - ppublish SO - JAMA Surg. 2019 Sep 1;154(9):861-866. doi: 10.1001/jamasurg.2019.2327. PMID- 21164145 OWN - NLM STAT- MEDLINE DCOM- 20150313 LR - 20181201 IS - 1939-4640 (Electronic) IS - 0196-3635 (Linking) VI - 32 IP - 5 DP - 2011 Sep-Oct TI - Tissue engineering penoplasty with biodegradable scaffold Maxpol-T cografted autologous fibroblasts for small penis syndrome. PG - 491-5 LID - 10.2164/jandrol.110.011247 [doi] AB - In this study, we investigated the safety and efficacy of a poly acid-co-glycolide biodegradable scaffold (Maxpol-T) coated by autologous fibroblasts (AF) for penile girth enlargement in small penis syndrome (SPS). Eighty patients with SPS were enrolled in a clinical study at 2 medical centers; 69 patients completed the study protocol. Scrotal skin was harvested under local anesthesia, and AFs were cultured and seeded on a Maxpol-T scaffold; the cografted scaffold was implanted under the Buck's fascia of penile shaft via a circumcising incision. Patients were followed up at 1, 3, and 6 months to evaluate penile girth changes. Patient satisfaction was assessed via Visual Analogue Scale and scored on the International Index of Erectile Function-5 (IIEF-5). Mean preoperative penile girth in the flaccid and erect state was 8.18 ± 0.83 cm and 10.26 ± 1.22 cm, respectively. At the 6-month postoperative follow-up, mean penile girth in the flaccid and erect state was increased to 12.19 ± 1.27 cm and 13.18 ± 1.31 cm, respectively (P < .001 for change in both flaccid and erect state). Sixty-five patients (94.2%) reported satisfaction with the procedure. Among them, 4 cases (5.8%) were dissatisfied, 7 cases (10.1%) were satisfied, 26 cases (37.7%) were very satisfied, and 32 cases (46.4%) were extremely satisfied. All men maintained IIEF-5 scores of more than 22. Complications included prolonged subcutaneous edema in 3 patients (4.3%) and pinpoint erosion at the suture area in 3 patients (4.3%). Implantation of autologous fibroblasts seeded on a Maxpol-T collagen scaffold holds promise as a safe and novel technique for penile girth enhancement in patients with SPS. FAU - Jin, Zhe AU - Jin Z AD - Andrology Center, Peking University First Hospital, Peking University, Beijing (100009), China. xinzc08@gmail.com FAU - Wu, Yi-Guang AU - Wu YG FAU - Yuan, Yi-Ming AU - Yuan YM FAU - Peng, Jing AU - Peng J FAU - Gong, Yan-Qing AU - Gong YQ FAU - Li, Guang-Yong AU - Li GY FAU - Song, Wei-Dong AU - Song WD FAU - Cui, Wan-Shou AU - Cui WS FAU - He, Xue-You AU - He XY FAU - Xin, Zhong-Cheng AU - Xin ZC LA - eng PT - Clinical Trial PT - Journal Article DEP - 20101216 PL - United States TA - J Androl JT - Journal of andrology JID - 8106453 RN - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer) RN - 26009-03-0 (Polyglycolic Acid) RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Adult MH - Fibroblasts/*transplantation MH - Humans MH - Lactic Acid MH - Male MH - Middle Aged MH - Patient Satisfaction MH - Penis/*surgery MH - Polyglycolic Acid MH - Polylactic Acid-Polyglycolic Acid Copolymer MH - Syndrome MH - Tissue Engineering/*instrumentation/*methods MH - Tissue Scaffolds MH - Urologic Surgical Procedures, Male/*instrumentation/*methods MH - Young Adult EDAT- 2010/12/18 06:00 MHDA- 2015/03/17 06:00 CRDT- 2010/12/18 06:00 PHST- 2010/12/18 06:00 [entrez] PHST- 2010/12/18 06:00 [pubmed] PHST- 2015/03/17 06:00 [medline] AID - jandrol.110.011247 [pii] AID - 10.2164/jandrol.110.011247 [doi] PST - ppublish SO - J Androl. 2011 Sep-Oct;32(5):491-5. doi: 10.2164/jandrol.110.011247. Epub 2010 Dec 16. PMID- 36474900 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221207 IS - 0513-5710 (Print) IS - 1346-8049 (Electronic) IS - 0513-5710 (Linking) VI - 65 IP - 4 DP - 2022 Nov TI - Robot-Assisted Total Hysterectomy of Extremely Unusual Pelvic Anatomy: A Case Report and Literature Review. PG - 315-319 LID - 10.33160/yam.2022.11.003 [doi] AB - We report a case of robot-assisted total hysterectomy in a patient with extremely rare pelvic anatomy. Robot-assisted total laparoscopic hysterectomy was performed for lobular endocervical glandular hyperplasia on the left side of the uterus. The sigmoid colon was present between the two uterine corpora of a uterine didelphys and was attached to the bladder via the mesentery and fat. During surgery, the surgeon left the console and confirmed the magnetic resonance images. The surgery was then completed safely after the surgeon understood the anatomy. The postoperative condition was good, and the patient was discharged on postoperative day 5. Robot-assisted surgery has various advantages, including a good field of view, accuracy of instrument movement, and ease of viewing information in the medical record by pausing the operation. Robot assisted surgery improves not only safety and operational precision but also intraoperative convenience. Further studies are needed regarding the specific anatomy seen in this case. CI - ©2022 Tottori University Medical Press. FAU - Nagata, Hiroki AU - Nagata H AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. FAU - Komatsu, Hiroaki AU - Komatsu H AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. FAU - Nakaso, Takaya AU - Nakaso T AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. FAU - Kudoh, Akiko AU - Kudoh A AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. FAU - Azuma, Yukihiro AU - Azuma Y AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. FAU - Taniguchi, Fuminori AU - Taniguchi F AD - Division of Obstetrics and Gynecology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. LA - eng PT - Case Reports PT - Journal Article DEP - 20221025 PL - Japan TA - Yonago Acta Med JT - Yonago acta medica JID - 0414002 PMC - PMC9691378 OTO - NOTNLM OT - anatomy OT - didelphic uterus OT - endocervical glandular hyperplasia OT - hysterectomy OT - robotic surgery COIS- The authors declare no conflict of interest. EDAT- 2022/12/08 06:00 MHDA- 2022/12/08 06:01 PMCR- 2022/10/25 CRDT- 2022/12/07 02:10 PHST- 2022/08/01 00:00 [received] PHST- 2022/09/14 00:00 [accepted] PHST- 2022/12/07 02:10 [entrez] PHST- 2022/12/08 06:00 [pubmed] PHST- 2022/12/08 06:01 [medline] PHST- 2022/10/25 00:00 [pmc-release] AID - 2022.11.003 [pii] AID - 10.33160/yam.2022.11.003 [doi] PST - epublish SO - Yonago Acta Med. 2022 Oct 25;65(4):315-319. doi: 10.33160/yam.2022.11.003. eCollection 2022 Nov. PMID- 23907959 OWN - NLM STAT- MEDLINE DCOM- 20140211 LR - 20220408 IS - 1531-4995 (Electronic) IS - 0023-852X (Linking) VI - 123 IP - 10 DP - 2013 Oct TI - Variation in post-adenotonsillectomy admission practices in 24 pediatric hospitals. PG - 2560-6 LID - 10.1002/lary.24172 [doi] AB - OBJECTIVES/HYPOTHESIS: There is controversy about which children should be admitted after adenotonsillectomy (T&A) and limited clinical evidence to help with this decision. Current practice has evolved based on empirical or anecdotal evidence. We sought to identify practice variations in postoperative admission after T&A in tertiary care pediatric hospitals. STUDY DESIGN: Retrospective database study using administrative information stored in the Pediatric Health Information System (PHIS) database. METHODS: There were 29,920 T&As performed in 24 pediatric hospitals included in the PHIS database between July 1, 2009 and June 30, 2010. Patients were identified as outpatient (discharged the same day) or inpatient (not discharged on the day of surgery). We examined admission rates across different hospitals stratified by age, obstructive sleep apnea (OSA), and other complex chronic conditions. RESULTS: Younger age, the existence of a complex chronic condition, and OSA were all associated with higher post-T&A admission rates. Admission rates ranged from >94% for children under 2 years of age, with OSA and at least one medical comorbidity, to 14% for children older than 5 years, without OSA and without any medical comorbidities. Between-hospital variability was extreme; for example, for 3 to 5 year olds, the admission rate varied from 5% to 90% between hospitals. Very significant variation remained even after controlling for age, comorbidities, and OSA. CONCLUSIONS: Post T&A admission rates vary tremendously across comparable tertiary-care pediatric hospitals. There is a crucial need for a better understanding of the risk of complications on the first postoperative night, and the appropriate indications for monitored admission on that night. LEVEL OF EVIDENCE: 4. CI - Copyright © 2013 The American Laryngological, Rhinological and Otological Society, Inc. FAU - Goyal, Samita S AU - Goyal SS AD - Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. FAU - Shah, Rahul AU - Shah R FAU - Roberson, David W AU - Roberson DW FAU - Schwartz, Margot L AU - Schwartz ML LA - eng PT - Journal Article DEP - 20130731 PL - United States TA - Laryngoscope JT - The Laryngoscope JID - 8607378 SB - IM MH - *Adenoidectomy MH - Adolescent MH - Age Factors MH - Child MH - Child, Preschool MH - Chronic Disease MH - Databases, Factual MH - Female MH - Hospitalization/*statistics & numerical data MH - Hospitals, Pediatric MH - Humans MH - Infant MH - Length of Stay MH - Male MH - Patient Safety MH - Practice Patterns, Physicians' MH - Retrospective Studies MH - Sleep Apnea, Obstructive/epidemiology MH - *Tonsillectomy OTO - NOTNLM OT - Practice variation OT - adenoidectomy OT - admissions OT - obstructive sleep apnea OT - patient safety OT - tonsillectomy EDAT- 2013/08/03 06:00 MHDA- 2014/02/12 06:00 CRDT- 2013/08/03 06:00 PHST- 2012/07/25 00:00 [received] PHST- 2013/03/08 00:00 [revised] PHST- 2013/04/01 00:00 [accepted] PHST- 2013/08/03 06:00 [entrez] PHST- 2013/08/03 06:00 [pubmed] PHST- 2014/02/12 06:00 [medline] AID - 10.1002/lary.24172 [doi] PST - ppublish SO - Laryngoscope. 2013 Oct;123(10):2560-6. doi: 10.1002/lary.24172. Epub 2013 Jul 31. PMID- 36854413 OWN - NLM STAT- MEDLINE DCOM- 20240124 LR - 20240124 IS - 1003-9406 (Print) IS - 1003-9406 (Linking) VI - 40 IP - 3 DP - 2023 Mar 10 TI - [Clinical characteristics and genetic analysis of a patient with STISS syndrome due to variant of PSMD12 gene]. PG - 349-353 LID - 10.3760/cma.j.cn511374-20220207-00097 [doi] AB - OBJECTIVE: To investigate the clinical and genetic characteristics of a patient with STISS syndrome due to variant of PSMD12 gene. METHODS: Clinical data and result of genetic testing of a patient who was admitted to Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine on October 4, 2020 were analyzed, together with a review of relevant literature. RESULTS: The patient was found to harbor a heterozygous c.601C>T (p.Arg201*) nonsense variant of the PSMD12 gene, which was unreported previously. Clinically, the height of the patient has differed significantly from reported in the literature. An extremely rare case of STISS syndrome due to variant of the PSMD12 gene has been diagnosed. CONCLUSION: Whether the severely short stature is part of the clinical spectrum for PSMD12 gene variants needs to be further explored, and the efficacy and safety of growth hormone therapy has yet to be determined. FAU - Xu, Lei AU - Xu L AD - Department of Endocrinology and Metabolism, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. dingyu@scmc.com.cn. FAU - Wang, Yirou AU - Wang Y FAU - Zhang, Qianwen AU - Zhang Q FAU - Chen, Yao AU - Chen Y FAU - Chang, Guoying AU - Chang G FAU - Wang, Xiumin AU - Wang X FAU - Wang, Jian AU - Wang J FAU - Ding, Yu AU - Ding Y LA - chi PT - Case Reports PT - English Abstract PT - Journal Article PT - Review PL - China TA - Zhonghua Yi Xue Yi Chuan Xue Za Zhi JT - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JID - 9425197 RN - 0 (PSMD12 protein, human) SB - IM MH - Child MH - Humans MH - China MH - *Dwarfism MH - Genetic Testing MH - Heterozygote MH - Syndrome EDAT- 2023/03/01 06:00 MHDA- 2023/03/03 06:00 CRDT- 2023/02/28 19:23 PHST- 2023/02/28 19:23 [entrez] PHST- 2023/03/01 06:00 [pubmed] PHST- 2023/03/03 06:00 [medline] AID - 940640065 [pii] AID - 10.3760/cma.j.cn511374-20220207-00097 [doi] PST - ppublish SO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2023 Mar 10;40(3):349-353. doi: 10.3760/cma.j.cn511374-20220207-00097. PMID- 22568146 OWN - NLM STAT- MEDLINE DCOM- 20120802 LR - 20120508 IS - 0047-1852 (Print) IS - 0047-1852 (Linking) VI - 70 IP - 4 DP - 2012 Apr TI - [Adverse drug reactions of antiviral agents]. PG - 635-41 AB - Principally speaking, "drug" and "poison" are of the same class; therefore, overdose of any drug naturally leads to intoxication. Intoxication can also occur in regular doses, depending on the condition of a patient (e.g., renal insufficiency). In addition, each drug has its own side effects which occur at a certain probability, and there is no exception to antivirals. Antivirals for common acute viral diseases are used for a number of people, and those for chronic viral diseases are used for a long period. In both cases, side effects are an extremely important issue. Without precise and prompt safety measures, we won't succeed in antiviral treatment. FAU - Moriuchi, Masako AU - Moriuchi M AD - Department of Medical Virology, Nagasaki University Graduate School of Biomedical Sciences. FAU - Moriuchi, Hiroyuki AU - Moriuchi H LA - jpn PT - English Abstract PT - Journal Article PT - Review PL - Japan TA - Nihon Rinsho JT - Nihon rinsho. Japanese journal of clinical medicine JID - 0420546 RN - 0 (Antiviral Agents) RN - EC 3.2.1.18 (Neuraminidase) SB - IM MH - Antiviral Agents/*adverse effects MH - Herpesviridae/drug effects MH - Humans MH - Neuraminidase/antagonists & inhibitors MH - Virus Diseases/drug therapy EDAT- 2012/05/10 06:00 MHDA- 2012/08/03 06:00 CRDT- 2012/05/10 06:00 PHST- 2012/05/10 06:00 [entrez] PHST- 2012/05/10 06:00 [pubmed] PHST- 2012/08/03 06:00 [medline] PST - ppublish SO - Nihon Rinsho. 2012 Apr;70(4):635-41. PMID- 27320544 OWN - NLM STAT- MEDLINE DCOM- 20170103 LR - 20181202 IS - 1873-2623 (Electronic) IS - 0041-1345 (Linking) VI - 48 IP - 4 DP - 2016 May TI - Impact of Different Dominant Hepatic Vein Patterns in Left-Lobe Donors of Adult Living Donor Liver Transplantation. PG - 1012-4 LID - S0041-1345(16)00249-9 [pii] LID - 10.1016/j.transproceed.2015.12.128 [doi] AB - OBJECTIVE: Optimal hepatic venous tributary flow is correlated with liver function and regeneration. In left-lobe graft living donor liver transplantation, the stump of segment 5 and 8 hepatic veins (S5V and S8V) are ligated without performing hepatic tributary reconstruction. The aim of this article was to evaluate the different dominate hepatic vein patterns that affect left-lobe living donor safety. MATERIALS AND METHODS: A total of 44 donors who underwent left-lobe hepatectomy were divided into 2 groups, middle hepatic vein (MHV) dominance (group 1) and right hepatic vein (RHV) dominance (group 2), according to the dominant venous territory drainage from S5V and S8V or RHV. The clinical pathological data, postoperative laboratory data, complication, remnant liver volume and remnant liver regeneration rate at 6 months after surgery were compared. RESULTS: No difference was found in blood loss, postoperative liver function such as alanine transaminase value, complications, and hospital stays between groups. Group 1 had slightly higher total bilirubin level than group 2 (1.99 vs 1.79; P = .49). Group 2 had significantly better remnant liver regeneration rate than group 1 (89.2% vs 82.5%; P = .026). CONCLUSION: It is important to recognize the dominant MHV group. Ligation large S5V and S8V in dominant MHV donors led to lower remnant liver regeneration in our series. This might be critical in extremely small RHV territory and potential large remnant liver congestion donors. Adjusting surgical planning, such as hepatic vein reconstruction, in this kind of donor might be appropriate for donor safety. CI - Copyright © 2016 Elsevier Inc. All rights reserved. FAU - Tung, Y-C AU - Tung YC AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Cheng, Y-F AU - Cheng YF AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Huang, T-L AU - Huang TL AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Chen, T-Y AU - Chen TY AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Ou, H-Y AU - Ou HY AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Yu, C-Y AU - Yu CY AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Hsu, H-W AU - Hsu HW AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Chen, C-L AU - Chen CL AD - Departments of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. FAU - Tsang, L L-C AU - Tsang LL AD - Liver Transplantation Program and Departments of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address: leolctsang@gmail.com. LA - eng PT - Journal Article PL - United States TA - Transplant Proc JT - Transplantation proceedings JID - 0243532 RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Adult MH - Alanine Transaminase/blood MH - End Stage Liver Disease/surgery MH - Female MH - Hepatectomy/methods MH - Hepatic Veins/*anatomy & histology/surgery MH - Humans MH - Liver/*blood supply MH - Liver Regeneration/physiology MH - *Liver Transplantation MH - *Living Donors MH - Middle Aged MH - Patient Safety MH - Postoperative Care MH - Young Adult EDAT- 2016/06/21 06:00 MHDA- 2017/01/04 06:00 CRDT- 2016/06/21 06:00 PHST- 2015/11/24 00:00 [received] PHST- 2015/12/30 00:00 [accepted] PHST- 2016/06/21 06:00 [entrez] PHST- 2016/06/21 06:00 [pubmed] PHST- 2017/01/04 06:00 [medline] AID - S0041-1345(16)00249-9 [pii] AID - 10.1016/j.transproceed.2015.12.128 [doi] PST - ppublish SO - Transplant Proc. 2016 May;48(4):1012-4. doi: 10.1016/j.transproceed.2015.12.128. PMID- 26383718 OWN - NLM STAT- MEDLINE DCOM- 20160115 LR - 20220318 IS - 1558-3597 (Electronic) IS - 0735-1097 (Linking) VI - 66 IP - 12 DP - 2015 Sep 22 TI - 2-Year Outcomes After Iliofemoral Self-Expanding Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis Deemed Extreme Risk for Surgery. PG - 1327-34 LID - S0735-1097(15)04598-2 [pii] LID - 10.1016/j.jacc.2015.07.042 [doi] AB - BACKGROUND: We reported favorable 1-year outcomes in patients unsuitable for surgery who underwent self-expanding transcatheter aortic valve replacement (TAVR) compared with an objective performance goal. Longer-term outcomes in these patients are not known. OBJECTIVES: This study sought to evaluate the 2-year safety and efficacy in patients with severe aortic stenosis (AS) at extreme risk of surgery treated with self-expanding TAVR. METHODS: We performed a prospective, multicenter, controlled, nonrandomized investigation of self-expanding TAVR in patients with severe AS and prohibitive surgical risk. We report the 2-year clinical outcomes in these patients. RESULTS: A total of 489 extreme-risk patients were treated transfemorally with a self-expanding aortic bioprosthesis at 41 centers. The rate of all-cause mortality or major stroke was 38.0% at 2 years (all-cause mortality, 36.5%; major stroke, 5.1%). The rates of all-cause mortality, cardiovascular mortality, and major stroke were 36.6%, 26.2%, and 5.1%, respectively, at 2 years. Between 1 and 2 years, the incremental all-cause mortality, cardiovascular mortality, and major stroke rates were 12.3%, 7.9%, and 0.8%, respectively. Multivariable predictors of all-cause mortality at 2 years included the presence of coronary artery disease and admission from an assisted living center. A Society of Thoracic Surgeons score >15% was also predictive of 2-year all-cause mortality. At 2 years, 94% of patients had New York Heart Association functional class I or II symptoms. The frequency of moderate or severe paravalvular regurgitation (4.3% at 1 year; 4.4% at 2 years) was unchanged between the first and second year. CONCLUSIONS: Patients with severe AS at extreme surgical risk treated with self-expanding TAVR continued to show good clinical outcomes and hemodynamic valve performance at 2 years. The presence of comorbid conditions rather than valve performance affected 2-year outcomes in these patients. (Safety and Efficacy Study of the Medtronic CoreValve System in the Treatment of Symptomatic Severe Aortic Stenosis in High Risk and Very High Risk Subjects Who Need Aortic Valve Replacement; NCT01240902). CI - Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Yakubov, Steven J AU - Yakubov SJ AD - Riverside Methodist Hospital, Columbus, Ohio. Electronic address: steven.yakubov@gmail.com. FAU - Adams, David H AU - Adams DH AD - Mount Sinai Health System, New York, New York. FAU - Watson, Daniel R AU - Watson DR AD - Riverside Methodist Hospital, Columbus, Ohio. FAU - Reardon, Michael J AU - Reardon MJ AD - Houston-Methodist-DeBakey Heart and Vascular Center, Houston, Texas. FAU - Kleiman, Neal S AU - Kleiman NS AD - Houston-Methodist-DeBakey Heart and Vascular Center, Houston, Texas. FAU - Heimansohn, David AU - Heimansohn D AD - St. Vincent's Heart Center of Indiana, Indianapolis, Indiana. FAU - Hermiller, James Jr AU - Hermiller J Jr AD - St. Vincent's Heart Center of Indiana, Indianapolis, Indiana. FAU - Hughes, G Chad AU - Hughes GC AD - Duke University Medical Center, Durham, North Carolina. FAU - Harrison, J Kevin AU - Harrison JK AD - Duke University Medical Center, Durham, North Carolina. FAU - Coselli, Joseph AU - Coselli J AD - Texas Heart Institute at St. Luke's Medical Center, Houston, Texas. FAU - Diez, Jose AU - Diez J AD - Texas Heart Institute at St. Luke's Medical Center, Houston, Texas. FAU - Schreiber, Theodore AU - Schreiber T AD - Detroit Medical Center, Detroit, Michigan. FAU - Gleason, Thomas G AU - Gleason TG AD - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. FAU - Conte, John AU - Conte J AD - Johns Hopkins Medical Center, Baltimore, Maryland. FAU - Deeb, G Michael AU - Deeb GM AD - University of Michigan Medical Center, Ann Arbor, Michigan. FAU - Huang, Jian AU - Huang J AD - Medtronic, Minneapolis, Minnesota. FAU - Oh, Jae AU - Oh J AD - Mayo Clinic Foundation, Rochester, Minnesota. FAU - Byrne, Timothy AU - Byrne T AD - Banner Good Samaritan Hospital, Phoenix, Arizona. FAU - Caskey, Michael AU - Caskey M AD - Banner Good Samaritan Hospital, Phoenix, Arizona. FAU - Popma, Jeffrey J AU - Popma JJ AD - Beth Israel Deaconess Medical Center, Boston, Massachusetts. CN - CoreValve United States Clinical Investigators LA - eng SI - ClinicalTrials.gov/NCT01240902 PT - Controlled Clinical Trial PT - Journal Article PT - Multicenter Study PL - United States TA - J Am Coll Cardiol JT - Journal of the American College of Cardiology JID - 8301365 SB - IM CIN - J Am Coll Cardiol. 2015 Sep 22;66(12):1335-8. doi: 10.1016/j.jacc.2015.04.085. PMID: 26383719 CIN - J Am Coll Cardiol. 2016 Feb 2;67(4):460. doi: 10.1016/j.jacc.2015.09.108. PMID: 26821639 CIN - J Am Coll Cardiol. 2016 Feb 2;67(4):461. doi: 10.1016/j.jacc.2015.10.075. PMID: 26821640 MH - Aged MH - Aged, 80 and over MH - Aortic Valve Stenosis/diagnostic imaging/*surgery MH - Echocardiography MH - Female MH - Humans MH - Male MH - Prospective Studies MH - Transcatheter Aortic Valve Replacement/instrumentation/*mortality MH - Treatment Outcome MH - United States/epidemiology OTO - NOTNLM OT - extreme risk OT - self-expanding OT - severe aortic stenosis OT - transcatheter aortic valve replacement EDAT- 2015/09/19 06:00 MHDA- 2016/01/16 06:00 CRDT- 2015/09/19 06:00 PHST- 2015/02/16 00:00 [received] PHST- 2015/07/15 00:00 [revised] PHST- 2015/07/16 00:00 [accepted] PHST- 2015/09/19 06:00 [entrez] PHST- 2015/09/19 06:00 [pubmed] PHST- 2016/01/16 06:00 [medline] AID - S0735-1097(15)04598-2 [pii] AID - 10.1016/j.jacc.2015.07.042 [doi] PST - ppublish SO - J Am Coll Cardiol. 2015 Sep 22;66(12):1327-34. doi: 10.1016/j.jacc.2015.07.042. PMID- 29076553 OWN - NLM STAT- MEDLINE DCOM- 20190409 LR - 20211204 IS - 1532-6535 (Electronic) IS - 0009-9236 (Linking) VI - 103 IP - 2 DP - 2018 Feb TI - Reverse and Forward Translational Neuropharmacology in Psychiatric Drug Discovery. PG - 193-195 LID - 10.1002/cpt.901 [doi] AB - The probability of achieving marketing approval of a novel therapeutic for psychiatric indications is extremely low due largely to the inability to demonstrate durable and reproducible efficacy in phase II trials and beyond. These failures are often attributed to the lack of translation of the underlying neuropharmacology from animal model(s) to the disease population. However, how assured is such a conclusion considering the clinical efficacy path rarely meticulously parallels the preclinical experiment(s) that underwrote it? CI - © 2017 American Society for Clinical Pharmacology and Therapeutics. FAU - Shaffer, Christopher L AU - Shaffer CL AD - Neuroscience and Pain Research Unit, Worldwide Research & Development, Pfizer Inc., Cambridge, Massachusetts, USA. LA - eng PT - Journal Article DEP - 20171027 PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Central Nervous System Agents) RN - 0 (Excitatory Amino Acid Antagonists) RN - 0 (PF-04958242) RN - 0 (Receptors, Glutamate) RN - 0 (Receptors, N-Methyl-D-Aspartate) RN - 0 (Sulfonamides) RN - 0 (Thiophenes) RN - 0 (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human) RN - 690G0D6V8H (Ketamine) SB - IM MH - Animals MH - Central Nervous System/drug effects/metabolism/physiopathology MH - Central Nervous System Agents/pharmacokinetics/*pharmacology/toxicity MH - Data Mining MH - Databases, Factual MH - Drug Development/*methods MH - Drug Discovery/*methods MH - Evidence-Based Medicine/*methods MH - Excitatory Amino Acid Antagonists/pharmacokinetics/*pharmacology/toxicity MH - Humans MH - Ketamine/pharmacokinetics/*pharmacology/toxicity MH - Learning MH - Models, Animal MH - Models, Theoretical MH - Patient Safety MH - Receptors, Glutamate/drug effects/metabolism MH - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism MH - Risk Assessment MH - Sulfonamides/pharmacology MH - Thiophenes/pharmacology MH - Translational Research, Biomedical/*methods EDAT- 2017/10/28 06:00 MHDA- 2019/04/10 06:00 CRDT- 2017/10/28 06:00 PHST- 2017/08/15 00:00 [received] PHST- 2017/10/04 00:00 [revised] PHST- 2017/10/05 00:00 [accepted] PHST- 2017/10/28 06:00 [pubmed] PHST- 2019/04/10 06:00 [medline] PHST- 2017/10/28 06:00 [entrez] AID - 10.1002/cpt.901 [doi] PST - ppublish SO - Clin Pharmacol Ther. 2018 Feb;103(2):193-195. doi: 10.1002/cpt.901. Epub 2017 Oct 27. PMID- 39853166 OWN - NLM STAT- MEDLINE DCOM- 20250124 LR - 20250124 IS - 2162-2906 (Electronic) IS - 1096-2247 (Linking) VI - 75 IP - 2 DP - 2025 Feb TI - Ryegrass root-soil composites mechanical properties and its slope stability: Experimental study and numerical analysis. PG - 164-179 LID - 10.1080/10962247.2024.2436531 [doi] AB - Urbanization and infrastructure projects generate huge amount of construction and demolition waste (CDW), posing significant challenges for the environment and human health. In order to reduce the environment and safety risks caused by the CDW landfills, this study was amid to utilize plant roots to develop a root-CDW-soil system for strengthening the CDW and enhancing the slope stability of CDW landfills. A series of experimental analyses were conducted, focusing on shear tests of root-soil composites under various moisture conditions and root content ratios. The results indicate that the inclusion of ryegrass roots plays a critical role in significantly enhancing the shear strength of the soil, and the soil samples reinforced with 0.6 g of ryegrass roots exhibited a shear strength increase of up to 35% compared to the unreinforced samples. The slope stability treated by the plant roots was evaluated by finite element simulations under different rainfall conditions. The factor of safety (FoS) for reinforced slopes increased from 1.18 to 1.59 after five days of heavy rainfall (480 mm/d), highlighting the significant improvement in stability provided by the root systems. These findings suggest that the root-soil system offers a sustainable solution for slope management, reducing risks associated with construction waste and extreme weather conditions.Implications: Urbanization and infrastructure projects generate significant waste, posing environmental and safety challenges. This study investigates the enhancement of slope stability through the integration of ryegrass root systems. The findings indicate that ryegrass roots substantially improve soil shear strength and overall slope stability. Furthermore, the study demonstrates that these root systems enhance resilience to heavy rainfall, thereby mitigating the risk of slope failure. These results suggest that plant root systems offer a sustainable solution for slope management, effectively addressing environmental concerns related to construction waste and extreme weather conditions. This research provides a comprehensive understanding of the physical and mechanical properties of root-soil composites, thereby promoting their practical application in slope stabilization. FAU - Zhang, Zhibo AU - Zhang Z AD - School of Rail Transportation, Soochow University, Suzhou, People's Republic of China. FAU - Tian, Angran AU - Tian A AD - School of Rail Transportation, Soochow University, Suzhou, People's Republic of China. AD - Department of Civil Engineering, The University of Hong Kong, Hong Kong, People's Republic of China. FAU - Zhou, Yu AU - Zhou Y AD - School of Rail Transportation, Soochow University, Suzhou, People's Republic of China. FAU - Ding, Chuanjin AU - Ding C AD - School of Rail Transportation, Soochow University, Suzhou, People's Republic of China. FAU - Tang, Qiang AU - Tang Q AD - School of Rail Transportation, Soochow University, Suzhou, People's Republic of China. LA - eng PT - Journal Article DEP - 20250124 PL - United States TA - J Air Waste Manag Assoc JT - Journal of the Air & Waste Management Association (1995) JID - 9503111 RN - 0 (Soil) SB - IM MH - *Lolium MH - *Soil/chemistry MH - *Plant Roots MH - Waste Disposal Facilities EDAT- 2025/01/24 17:38 MHDA- 2025/01/24 17:39 CRDT- 2025/01/24 09:32 PHST- 2025/01/24 17:39 [medline] PHST- 2025/01/24 17:38 [pubmed] PHST- 2025/01/24 09:32 [entrez] AID - 10.1080/10962247.2024.2436531 [doi] PST - ppublish SO - J Air Waste Manag Assoc. 2025 Feb;75(2):164-179. doi: 10.1080/10962247.2024.2436531. Epub 2025 Jan 24. PMID- 1605898 OWN - NLM STAT- MEDLINE DCOM- 19920717 LR - 20181113 IS - 0114-5916 (Print) IS - 0114-5916 (Linking) VI - 7 IP - 2 DP - 1992 Mar-Apr TI - Thalidomide in human immunodeficiency virus (HIV) patients. A review of safety considerations. PG - 116-34 AB - The sedative thalidomide was withdrawn from the market 30 years ago because of its teratogenic and neurotoxic adverse effects. The compound was later discovered to be extremely effective in the treatment of erythema nodosum leprosum, a complication of lepromatous leprosy. This effect is probably due to a direct influence on the immune system, because thalidomide possesses no antibacterial activity. The compound is presently used as an experimental drug in the treatment of a variety of diseases with an autoimmune character, including recurrent aphthosis of nonviral and nonfungal origin in human immunodeficiency virus (HIV) patients. This article reviews the most important chemical and pharmacokinetic properties of thalidomide. The possible mechanisms of the nonsedative effects of thalidomide with respect to the safety of its use in HIV patients are discussed. Because the mechanism of the immunomodulatory effect of thalidomide is unknown, the possibility that the administration of this compound will accelerate the deterioration of the immunological status of HIV patients cannot be excluded. Clinical evidence suggests that thalidomide may aggravate the condition of patients with preexisting peripheral neuropathy. Hypersensitivity reactions to thalidomide may occur more frequently in HIV patients than in other patient groups. Because of the teratogenic activity of thalidomide, reliable contraception must be provided to female patients of childbearing age. Before the introduction of thalidomide therapy to an HIV patient presenting with oral ulcers, a fungal or viral origin of the lesions should be excluded. Thalidomide should not be used in patients with preexisting HIV-related peripheral polyneuropathy, polyradiculopathy or encephalopathy. In patients experiencing a complete remission, the discontinuation of thalidomide treatment and its reintroduction in the case of a relapse are preferable to maintenance therapy. FAU - Günzler, V AU - Günzler V AD - Division of Pharmaceutical Research, Hoechst AG, Frankfurt, Federal Republic of Germany. LA - eng PT - Journal Article PT - Review PL - New Zealand TA - Drug Saf JT - Drug safety JID - 9002928 RN - 4Z8R6ORS6L (Thalidomide) SB - IM MH - Female MH - Graft vs Host Disease/drug therapy MH - HIV Infections/*complications MH - Humans MH - Immune System/drug effects MH - Polyneuropathies/chemically induced MH - Stomatitis, Aphthous/drug therapy/etiology MH - Thalidomide/adverse effects/metabolism/*therapeutic use RF - 279 EDAT- 1992/03/01 00:00 MHDA- 1992/03/01 00:01 CRDT- 1992/03/01 00:00 PHST- 1992/03/01 00:00 [pubmed] PHST- 1992/03/01 00:01 [medline] PHST- 1992/03/01 00:00 [entrez] AID - 10.2165/00002018-199207020-00004 [doi] PST - ppublish SO - Drug Saf. 1992 Mar-Apr;7(2):116-34. doi: 10.2165/00002018-199207020-00004. PMID- 22024274 OWN - NLM STAT- MEDLINE DCOM- 20120612 LR - 20190221 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 50 IP - 2 DP - 2012 Feb TI - Gallium poisoning: a rare case report. PG - 212-5 LID - 10.1016/j.fct.2011.10.041 [doi] AB - The authors present a case of a college student who suffered acute gallium poisoning as a result of accidental exposure to gallium halide complexes. This is extremely rare and has never been reported in the literature. Acute symptoms after the incident, which initially presented as dermatitis and appeared relatively not life-threatening, rapidly progressed to dangerous episodes of tachycardia, tremors, dyspnea, vertigo, and unexpected black-outs. Had there been effective emergency medical care protocols, diagnostic testing, treatment and antidotes, the latent manifestations of irreversible cardiomyopathy may have been prevented. Given how quickly exposure led to morbidity, this article aims to raise an awareness of the toxic potential of gallium. This has particular relevance for workers involved in the production of semiconductors where there is a potential for accidental exposure to gallium by-products during device processing. It may also have implications for dentists who use gallium alloys to replace mercury containing amalgam. In the absence of threshold limit values and exposure limits for humans, as well as emergency medical guidelines for treatment of poisoning, the case calls on the National Institute for Occupational Safety and Health and the Occupational Safety and Health Administration to establish guidelines and medical management protocols specific for gallium. CI - Copyright © 2011 Elsevier Ltd. All rights reserved. FAU - Ivanoff, Chris S AU - Ivanoff CS AD - College of Dentistry, The University of Tennessee Health Science Center, 875 Union Avenue, Memphis, TN 38163, USA. civanoff@uthsc.edu FAU - Ivanoff, Athena E AU - Ivanoff AE FAU - Hottel, Timothy L AU - Hottel TL LA - eng PT - Case Reports PT - Journal Article DEP - 20111018 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - CH46OC8YV4 (Gallium) SB - IM MH - Chronic Disease MH - Drug Eruptions/*pathology MH - Female MH - Gallium/*poisoning MH - Heavy Metal Poisoning MH - Humans MH - Poisoning/*pathology MH - Safety MH - Young Adult EDAT- 2011/10/26 06:00 MHDA- 2012/06/13 06:00 CRDT- 2011/10/26 06:00 PHST- 2011/08/31 00:00 [received] PHST- 2011/10/07 00:00 [revised] PHST- 2011/10/07 00:00 [accepted] PHST- 2011/10/26 06:00 [entrez] PHST- 2011/10/26 06:00 [pubmed] PHST- 2012/06/13 06:00 [medline] AID - S0278-6915(11)00548-5 [pii] AID - 10.1016/j.fct.2011.10.041 [doi] PST - ppublish SO - Food Chem Toxicol. 2012 Feb;50(2):212-5. doi: 10.1016/j.fct.2011.10.041. Epub 2011 Oct 18. PMID- 32884435 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220416 IS - 0513-5710 (Print) IS - 1346-8049 (Electronic) IS - 0513-5710 (Linking) VI - 63 IP - 3 DP - 2020 Aug TI - Evaluating Health Impact at High Altitude in Antarctica and Effectiveness of Monitoring Oxygen Saturation. PG - 163-172 LID - 10.33160/yam.2020.08.004 [doi] AB - BACKGROUND: The Japanese Antarctic Research Expedition (JARE) has been conducting research activities in inland Antarctica, which is extremely cold dryland covered with a thick ice sheet. This environment may cause a health disorder called acute mountain sickness (AMS). To improve the safety of expedition members, we evaluated the impact of extreme environmental conditions on human health and the effectiveness of monitoring of hypoxia for the early detection of AMS. METHODS: In total, 9 members from JARE 59 were studied. Dome Fuji Station (Dome F), located 3,810 m above sea level (ASL), was the destination of the research party. We analyzed daily AMS scores (higher values correspond to more severe AMS-related symptoms), physiological findings, and percutaneous arterial blood oxygen saturation (SpO(2)) during the inland activity. We also determined the factors related to AMS scores. RESULTS: The average AMS score on arrival at Dome F was significantly higher than that at the departure point (560 m ASL). The average SpO(2) level was significantly lower than that at other points. The SpO(2) level correlated negatively with the AMS score in Spearman's rank correlation. Generalized estimating equations analysis showed that the AMS score was negatively associated with SpO(2) level and positively associated with age. CONCLUSION: Hypoxia is a contributory factor to AMS which we can easily assess by measuring the SpO(2) level with a pulse oximeter. SpO(2) monitoring is a potentially useful health management tool for members in inland Antarctic expeditions. In addition, our results are helpful for understanding physiological responses and health issues in extreme environments. CI - ©2020 Tottori University Medical Press. FAU - Otani, Shinji AU - Otani S AD - International Platform for Dryland Research and Education, Tottori University, Tottori 680-0001, Japan. FAU - Miyaoka, Yoichi AU - Miyaoka Y AD - Department of Gastroenterological Surgery I, Hokkaido University, Sapporo 060-8648, Japan. FAU - Ikeda, Atsushi AU - Ikeda A AD - Department of Urology, University of Tsukuba Hospital, Tsukuba 305-8576, Japan. FAU - Ohno, Giichiro AU - Ohno G AD - Department of Surgery, Tokatsu Hospital, Nagareyama 270-0153, Japan. AD - National Institute of Polar Research, Tachikawa 190-8518, Japan. FAU - Imura, Satoshi AU - Imura S AD - National Institute of Polar Research, Tachikawa 190-8518, Japan. FAU - Watanabe, Kentaro AU - Watanabe K AD - National Institute of Polar Research, Tachikawa 190-8518, Japan. FAU - Kurozawa, Youichi AU - Kurozawa Y AD - Division of Health Administration and Promotion, Department of Social Medicine, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan. LA - eng PT - Journal Article DEP - 20200629 PL - Japan TA - Yonago Acta Med JT - Yonago acta medica JID - 0414002 PMC - PMC7435112 OTO - NOTNLM OT - Antarctic regions OT - altitude sickness OT - cold temperature OT - hypoxia OT - oximetry COIS- The authors declare no conflict of interest. EDAT- 2020/09/05 06:00 MHDA- 2020/09/05 06:01 PMCR- 2020/06/29 CRDT- 2020/09/05 06:00 PHST- 2020/05/08 00:00 [received] PHST- 2020/06/03 00:00 [accepted] PHST- 2020/09/05 06:00 [entrez] PHST- 2020/09/05 06:00 [pubmed] PHST- 2020/09/05 06:01 [medline] PHST- 2020/06/29 00:00 [pmc-release] AID - 2020.08.004 [pii] AID - 10.33160/yam.2020.08.004 [doi] PST - epublish SO - Yonago Acta Med. 2020 Jun 29;63(3):163-172. doi: 10.33160/yam.2020.08.004. eCollection 2020 Aug. PMID- 39616173 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241203 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Nov 30 TI - Braking failure anti-rollover control and hardware-in-the-loop verification of wire-controlled heavy vehicles. PG - 29802 LID - 10.1038/s41598-024-80854-9 [doi] LID - 29802 AB - Considering the fault tolerance of EMB (Electro-Mechanical-Brake) braking failure and anti-rollover control at the same time is one of the urgent problems to be solved in the driving safety of X-by-wire vehicles. Accurate rollover index is a key part of anti-rollover control. Aiming at the problem that the traditional rollover index reflects that the unsprung mass of the vehicle is insufficiently affected by road excitation, a tripped vehicle rollover dynamic model is established based on single-wheel braking failure, and a rollover evaluation index NLTR (New Load-Transfer-Rate) suitable for braking failure is proposed. In order to improve the lateral safety of the vehicle when the line control fails, a hierarchical anti-rollover controller based on road adhesion coefficient identification, SM-ABS (Sliding-Mode-ABS) control and DBR (Differential-Braking-Redistribution) control is designed. Taking the rollover index threshold as the controller trigger condition, the controller effects under NLTR, traditional RI2 and standard LTR indicators are compared respectively. Simulation and HIL test show that the traditional index controller has failure risk under extreme conditions. The designed NLTR index controller can accurately evaluate the rollover risk of the vehicle, control the vehicle in time, and improve the vehicle stability by 68.18% under Fish-Hook condition. CI - © 2024. The Author(s). FAU - Zheng, Lufeng AU - Zheng L AD - Department of Mechanical Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. FAU - Lu, Yongjie AU - Lu Y AD - Department of Mechanical Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. lu-yongjie@163.com. AD - State Key Laboratory of Mechanical Behavior in Traffic Engineering Structure and System Safety, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. lu-yongjie@163.com. FAU - Wang, Jianxi AU - Wang J AD - Department of Civil Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. FAU - Li, Haoyu AU - Li H AD - Department of Mechanical Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. AD - State Key Laboratory of Mechanical Behavior in Traffic Engineering Structure and System Safety, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China. LA - eng GR - 12072204/National Natural Science Foundation of China/ GR - A2020210039/Natural Science Foundation of Hebei Province/ GR - E2024210149/Beijing-Tianjin-Hebei Basic Research Cooperation Project/ PT - Journal Article DEP - 20241130 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC11608256 OTO - NOTNLM OT - Braking failure OT - Differential braking OT - Hardware in the loop OT - NLTR OT - Road adhesion coefficient OT - Rollover COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2024/12/01 15:22 MHDA- 2024/12/01 15:23 PMCR- 2024/11/30 CRDT- 2024/11/30 23:16 PHST- 2024/09/12 00:00 [received] PHST- 2024/11/21 00:00 [accepted] PHST- 2024/12/01 15:23 [medline] PHST- 2024/12/01 15:22 [pubmed] PHST- 2024/11/30 23:16 [entrez] PHST- 2024/11/30 00:00 [pmc-release] AID - 10.1038/s41598-024-80854-9 [pii] AID - 80854 [pii] AID - 10.1038/s41598-024-80854-9 [doi] PST - epublish SO - Sci Rep. 2024 Nov 30;14(1):29802. doi: 10.1038/s41598-024-80854-9. PMID- 14503687 OWN - NLM STAT- MEDLINE DCOM- 20031119 LR - 20061115 IS - 1466-531X (Print) IS - 1466-531X (Linking) VI - 4 IP - 2 DP - 2003 Sep TI - Probiotics: time for a dose of realism. PG - 33-42 AB - There is already a long research and retail history of probiotics, but progress in the scientific and medical validation of these products has been extremely slow. Even now, adequate information by which the consumer and health professional can judge the efficacy and safety of retailed probiotics is lacking. Probiotic products have not been subjected to large scale trials of efficacy that are used in the pharmaceutical industry. Without these trials and subsequent approval by fastidious regulatory agencies such as the FDA (USA), probiotics continue to languish in the self-care health market. Optimistically, a new generation of probiotics may be developed that have medical validity with respect to the prevention or treatment of atopic and inflammatory bowel diseases. These new products, however, will need to be targeted at the alleviation of specific medical conditions, and the mechanistic basis of their effectiveness will need to be provided. FAU - Tannock, Gerald W AU - Tannock GW AD - Department of Microbiology, University of Otago, Dunedin, New Zealand. gerald.tannock@stonebow.otago.ac.nz LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Curr Issues Intest Microbiol JT - Current issues in intestinal microbiology JID - 100939156 SB - IM MH - Digestive System/immunology/microbiology MH - Homeostasis MH - Humans MH - Immune Tolerance MH - Inflammatory Bowel Diseases/diet therapy/immunology MH - Probiotics/adverse effects/standards/*therapeutic use MH - Safety RF - 66 EDAT- 2003/09/25 05:00 MHDA- 2003/12/03 05:00 CRDT- 2003/09/25 05:00 PHST- 2003/09/25 05:00 [pubmed] PHST- 2003/12/03 05:00 [medline] PHST- 2003/09/25 05:00 [entrez] PST - ppublish SO - Curr Issues Intest Microbiol. 2003 Sep;4(2):33-42. PMID- 28483873 OWN - NLM STAT- MEDLINE DCOM- 20180119 LR - 20240327 IS - 1471-2970 (Electronic) IS - 0962-8436 (Print) IS - 0962-8436 (Linking) VI - 372 IP - 1723 DP - 2017 Jun 19 TI - Effect of extreme sea surface temperature events on the demography of an age-structured albatross population. LID - 10.1098/rstb.2016.0143 [doi] LID - 20160143 AB - Climate changes include concurrent changes in environmental mean, variance and extremes, and it is challenging to understand their respective impact on wild populations, especially when contrasted age-dependent responses to climate occur. We assessed how changes in mean and standard deviation of sea surface temperature (SST), frequency and magnitude of warm SST extreme climatic events (ECE) influenced the stochastic population growth rate log(λ(s)) and age structure of a black-browed albatross population. For changes in SST around historical levels observed since 1982, changes in standard deviation had a larger (threefold) and negative impact on log(λ(s)) compared to changes in mean. By contrast, the mean had a positive impact on log(λ(s)). The historical SST mean was lower than the optimal SST value for which log(λ(s)) was maximized. Thus, a larger environmental mean increased the occurrence of SST close to this optimum that buffered the negative effect of ECE. This 'climate safety margin' (i.e. difference between optimal and historical climatic conditions) and the specific shape of the population growth rate response to climate for a species determine how ECE affect the population. For a wider range in SST, both the mean and standard deviation had negative impact on log(λ(s)), with changes in the mean having a greater effect than the standard deviation. Furthermore, around SST historical levels increases in either mean or standard deviation of the SST distribution led to a younger population, with potentially important conservation implications for black-browed albatrosses.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. CI - © 2017 The Author(s). FAU - Pardo, Deborah AU - Pardo D AUID- ORCID: 0000-0001-9593-1155 AD - Centre d'Etudes Biologiques de Chizé, UMR7372 CNRS, 79360 Villiers-en-Bois, France deborah.pardo@gmail.com. AD - British Antarctic Survey, Madingley Road High Cross, Cambridge CB3 0ET, UK. FAU - Jenouvrier, Stéphanie AU - Jenouvrier S AD - Centre d'Etudes Biologiques de Chizé, UMR7372 CNRS, 79360 Villiers-en-Bois, France. AD - Woods Hole Oceanographic Institution, Mailstop 50, Woods Hole, MA 02543, USA. FAU - Weimerskirch, Henri AU - Weimerskirch H AUID- ORCID: 0000-0002-0457-586X AD - Centre d'Etudes Biologiques de Chizé, UMR7372 CNRS, 79360 Villiers-en-Bois, France. FAU - Barbraud, Christophe AU - Barbraud C AUID- ORCID: 0000-0003-0146-212X AD - Centre d'Etudes Biologiques de Chizé, UMR7372 CNRS, 79360 Villiers-en-Bois, France. LA - eng PT - Journal Article PL - England TA - Philos Trans R Soc Lond B Biol Sci JT - Philosophical transactions of the Royal Society of London. Series B, Biological sciences JID - 7503623 SB - IM MH - Animals MH - Antarctic Regions MH - Birds/*physiology MH - *Climate Change MH - Indian Ocean MH - *Life History Traits MH - Models, Biological MH - *Oceans and Seas MH - Population Dynamics MH - *Temperature PMC - PMC5434094 OTO - NOTNLM OT - climate safety margin OT - matrix population model OT - population persistence OT - seabird COIS- We have no competing interests. EDAT- 2017/05/10 06:00 MHDA- 2018/01/20 06:00 PMCR- 2018/06/19 CRDT- 2017/05/10 06:00 PHST- 2017/03/07 00:00 [accepted] PHST- 2017/05/10 06:00 [entrez] PHST- 2017/05/10 06:00 [pubmed] PHST- 2018/01/20 06:00 [medline] PHST- 2018/06/19 00:00 [pmc-release] AID - rstb.2016.0143 [pii] AID - rstb20160143 [pii] AID - 10.1098/rstb.2016.0143 [doi] PST - ppublish SO - Philos Trans R Soc Lond B Biol Sci. 2017 Jun 19;372(1723):20160143. doi: 10.1098/rstb.2016.0143. PMID- 18624618 OWN - NLM STAT- MEDLINE DCOM- 20081006 LR - 20161018 IS - 1434-6621 (Print) IS - 1434-6621 (Linking) VI - 46 IP - 7 DP - 2008 TI - Microbial safety of cell based medicinal products--what can we learn from cellular blood components? PG - 963-5 LID - 10.1515/CCLM.2008.175 [doi] AB - Today, sterility of established parenteral drugs including biologicals, such as plasma derived products, is practically guaranteed. Bacterially contaminated products are extremely rare exceptions owing to the efficiency of the manufacturing processes in the pharmaceutical industry. In contrast, the manufacturing processes of cell based medicinal products or tissue preparations show much less defined conditions. The sterility of source materials cannot be guaranteed in many cases. As a rule, these source materials cannot be sterilised, as it holds true for the final products. Furthermore, the established methods for sterility testing are not applicable for cell preparations. Sterility of a restricted sample does not guarantee sterility of the whole preparation. Thus, small amounts of residual bacteria in the product can be overlooked and can grow up to enormous numbers during storage and shipping of cell based medicinal products. Considering these problems, there are some parallels in the warranty of microbial safety of cellular blood components. Therefore, the experiences collected in transfusion medicine in the past decade can be successfully used in the production of cell based medicinal products. Comparable to the situation regarding cellular blood components, there is a need for new principles in rapid bacteria detection. FAU - Montag, Thomas AU - Montag T AD - Paul Ehrlich Institute, Federal Agency for Sera and Vaccines, Langen, Germany. month@pei.de FAU - Nicol, Sven-Boris AU - Nicol SB FAU - Schurig, Utta AU - Schurig U FAU - Heiden, Margarete AU - Heiden M FAU - Huber, Helga AU - Huber H FAU - Sanzenbacher, Ralf AU - Sanzenbacher R FAU - Flory, Egbert AU - Flory E FAU - Schwanig, Michael AU - Schwanig M FAU - Schneider, Christian K AU - Schneider CK LA - eng PT - Journal Article PT - Review PL - Germany TA - Clin Chem Lab Med JT - Clinical chemistry and laboratory medicine JID - 9806306 SB - IM MH - Bacteria/*isolation & purification MH - Bacterial Infections/microbiology/*prevention & control MH - Blood Banks MH - Blood Cells/*microbiology MH - Cells/*microbiology MH - Drug Contamination/prevention & control MH - Humans MH - *Safety RF - 3 EDAT- 2008/07/16 09:00 MHDA- 2008/10/07 09:00 CRDT- 2008/07/16 09:00 PHST- 2008/07/16 09:00 [pubmed] PHST- 2008/10/07 09:00 [medline] PHST- 2008/07/16 09:00 [entrez] AID - 10.1515/CCLM.2008.175 [pii] AID - 10.1515/CCLM.2008.175 [doi] PST - ppublish SO - Clin Chem Lab Med. 2008;46(7):963-5. doi: 10.1515/CCLM.2008.175. PMID- 39952755 OWN - NLM STAT- MEDLINE DCOM- 20250214 LR - 20250214 IS - 1095-9998 (Electronic) IS - 0740-0020 (Linking) VI - 128 DP - 2025 Jun TI - Stresses in the food chain and their impact on antibiotic resistance of foodborne pathogens: A review. PG - 104741 LID - S0740-0020(25)00021-8 [pii] LID - 10.1016/j.fm.2025.104741 [doi] AB - Antibiotic resistance in foodborne pathogens represents a major public health concern. The farm-to-fork continuum is recognized as a critical pathway for the development and spread of this resistance. Throughout the food chain, foodborne pathogens are exposed to diverse environmental stresses, including temperature extremes, osmotic pressure, food additives, and disinfectants, and others. These stress factors can influence antibiotic resistance, with effects varying based on the type and intensity of stress, the pathogen species and strain, and the specific antibiotic involved. Stress conditions can trigger bacterial adaptive responses, such as general stress response systems, the SOS response, and genetic mutations, which can confer cross-protection and enhance antibiotic resistance. Conversely, stress-induced injury or metabolic suppression may increase bacterial susceptibility to certain antibiotics. Understanding these complex interactions is crucial, as suboptimal food processing can inadvertently select for resistant strains. Investigating the molecular mechanisms underlying stress adaptation is essential for developing effective strategies to mitigate antibiotic resistance. Optimizing food processing protocols and implementing robust monitoring systems throughout the food chain are essential steps to reduce these risks. A comprehensive understanding of stress-induced antibiotic resistance will provide a scientific basis for improving food safety and safeguarding global public health. CI - Copyright © 2025 Elsevier Ltd. All rights reserved. FAU - Li, Yun AU - Li Y AD - School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. FAU - Wu, Yufan AU - Wu Y AD - Centre of Analysis and Test, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai, China. FAU - Shao, Jingdong AU - Shao J AD - Technology Center of Zhangjiagang Customs, Suzhou, China. FAU - Shi, Juping AU - Shi J AD - Zhangjiagang Centre for Disease Control and Prevention, Suzhou, China. FAU - Sun, Lu AU - Sun L AD - School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. FAU - Hong, Yi AU - Hong Y AD - Food Microbiology and Food Preservation Research Unit, Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Belgium. FAU - Wang, Xiang AU - Wang X AD - School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. Electronic address: xiang.wang@usst.edu.cn. LA - eng PT - Journal Article PT - Review DEP - 20250203 PL - England TA - Food Microbiol JT - Food microbiology JID - 8601127 RN - 0 (Anti-Bacterial Agents) SB - IM MH - *Foodborne Diseases/microbiology/prevention & control MH - *Anti-Bacterial Agents/pharmacology MH - *Bacteria/drug effects/genetics MH - *Food Chain MH - *Stress, Physiological MH - *Drug Resistance, Bacterial MH - Humans MH - *Food Microbiology MH - Food Safety MH - Food Handling OTO - NOTNLM OT - Antibiotics OT - Cross protection OT - Hurdle factors OT - Microbial food safety OT - Stress response COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/15 15:11 MHDA- 2025/02/15 15:12 CRDT- 2025/02/14 20:59 PHST- 2024/11/24 00:00 [received] PHST- 2025/01/07 00:00 [revised] PHST- 2025/01/31 00:00 [accepted] PHST- 2025/02/15 15:12 [medline] PHST- 2025/02/15 15:11 [pubmed] PHST- 2025/02/14 20:59 [entrez] AID - S0740-0020(25)00021-8 [pii] AID - 10.1016/j.fm.2025.104741 [doi] PST - ppublish SO - Food Microbiol. 2025 Jun;128:104741. doi: 10.1016/j.fm.2025.104741. Epub 2025 Feb 3. PMID- 9255229 OWN - NLM STAT- MEDLINE DCOM- 19970904 LR - 20190630 IS - 0022-3476 (Print) IS - 0022-3476 (Linking) VI - 131 IP - 1 Pt 2 DP - 1997 Jul TI - Partial growth-hormone insensitivity: the role of growth-hormone receptor mutations in idiopathic short stature. PG - S51-5 AB - Mutations in the GHR locus may play a role in the cause of idiopathic short stature (ISS) by impairing growth-hormone (GH) receptor (GHR) function. At one extreme, mutations that nullify the function of the GH receptor are linked to complete GH insensitivity syndrome, or Laron syndrome, and we hypothesized that less-disruptive mutations could contribute to partial GH insensitivity syndrome. Low levels of GH binding protein may indicate mutations in the extracellular domain of the receptor, and by focusing on 14 children with ISS who had low GH binding protein and insulin-like growth factor I levels, we found three heterozygotes and one compound heterozygote for mutations in the extracellular domain of the receptor. We have since extended our study to a broader spectrum of patients, adding 76 patients with ISS who were treated with GH in a phase II study of the safety and efficacy of recombinant human GH in ISS and also adding 10 patients who were ascertained as having ISS by pediatric endocrinologists in private practice. The GHR gene has thus been analyzed in 100 patients with ISS, eight of whom were found to carry mutations: four in our original study and four with normal or elevated levels of GH binding protein. The latter group consists of three carriers of heterozygous extracellular domain mutations and one carrier of a heterozygous intracellular domain mutation. Family data suggest that the carriers of these mutations have a range of phenotypes, supporting our hypothesis that the expression of these heterozygous mutations as partial GH insensitivity syndrome depends on the genetic makeup of the person. FAU - Goddard, A D AU - Goddard AD AD - Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94060, USA. FAU - Dowd, P AU - Dowd P FAU - Chernausek, S AU - Chernausek S FAU - Geffner, M AU - Geffner M FAU - Gertner, J AU - Gertner J FAU - Hintz, R AU - Hintz R FAU - Hopwood, N AU - Hopwood N FAU - Kaplan, S AU - Kaplan S FAU - Plotnick, L AU - Plotnick L FAU - Rogol, A AU - Rogol A FAU - Rosenfield, R AU - Rosenfield R FAU - Saenger, P AU - Saenger P FAU - Mauras, N AU - Mauras N FAU - Hershkopf, R AU - Hershkopf R FAU - Angulo, M AU - Angulo M FAU - Attie, K AU - Attie K LA - eng PT - Clinical Trial PT - Clinical Trial, Phase II PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 RN - 0 (Carrier Proteins) RN - 0 (Receptors, Somatotropin) RN - 12629-01-5 (Human Growth Hormone) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 9002-72-6 (Growth Hormone) RN - W06KFL3RDT (somatotropin-binding protein) SB - IM MH - Body Height/*genetics MH - Carrier Proteins/blood/genetics MH - Child MH - Child, Preschool MH - Chromosome Mapping MH - Female MH - Gene Expression Regulation MH - Genes/genetics MH - Growth Disorders/drug therapy/*genetics MH - Growth Hormone/therapeutic use MH - Heterozygote MH - Human Growth Hormone/blood/*genetics/therapeutic use MH - Humans MH - Insulin-Like Growth Factor I/analysis/genetics MH - Male MH - Mutation/*genetics MH - Phenotype MH - Polymorphism, Genetic/genetics MH - Polymorphism, Single-Stranded Conformational MH - Receptors, Somatotropin/*genetics/physiology MH - Safety MH - Syndrome EDAT- 1997/07/01 00:00 MHDA- 1997/07/01 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/07/01 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] AID - a81743 [pii] AID - 10.1016/s0022-3476(97)70012-x [doi] PST - ppublish SO - J Pediatr. 1997 Jul;131(1 Pt 2):S51-5. doi: 10.1016/s0022-3476(97)70012-x. PMID- 20642705 OWN - NLM STAT- MEDLINE DCOM- 20111110 LR - 20240416 IS - 1742-1241 (Electronic) IS - 1368-5031 (Print) IS - 1368-5031 (Linking) VI - 64 IP - 8 DP - 2010 Jul TI - Design and rationale for the non-interventional Global Investigation of Therapeutic DEcisions in Hepatocellular Carcinoma and Of its Treatment with Sorafenib (GIDEON) study. PG - 1034-41 LID - 10.1111/j.1742-1241.2010.02414.x [doi] AB - BACKGROUND: Hepatocellular carcinoma (HCC) is a complicated condition influenced by multiple confounding factors, making optimum patient management extremely challenging. Ethnicity, stage at diagnosis, comorbidities and tumour morphology affect outcomes and vary from region to region, and there is no common language to assess patient prognosis and make treatment recommendations. Despite recent efforts to reduce the incidence of HCC, most patients present with unresectable disease. Non-surgical treatments include ablation, transarterial chemoembolisation and the multikinase inhibitor, sorafenib, but their effects in all patient subgroups are not known and further information is needed to optimise the use of these treatments. AIMS: The Global Investigation of Therapeutic DEcisions in Hepatocellular Carcinoma and Of its Treatment with SorafeNib (GIDEON) study (ClinicalTrials.gov identifier NCT00812175; http://clinicaltrials.gov/) is an ongoing global, prospective, non-interventional study of patients with unresectable HCC who are eligible for systemic therapy and for whom the decision has been taken to treat with sorafenib under real-life practice conditions. The aim of this study is to evaluate the safety and efficacy of sorafenib in different subgroups, especially Child-Pugh B where data are limited. DISCUSSION: This study will recruit 3000 patients from > 40 countries and follow them for approximately 5 years to compile a large and robust database of information that will be used to analyse local, regional and global differences in baseline characteristics, disease aetiology, treatment practice patterns and treatment outcomes, with a view to improve the knowledge base used to guide physician treatment decisions and to improve patient outcomes. FAU - Lencioni, R AU - Lencioni R AD - Division of Diagnostic Imaging and Intervention, Department of Liver Transplantation, Hepatology and Infectious Diseases, Pisa University School of Medicine, Cisanello Hospital, Pisa, Italy. lencioni@med.unipi.it FAU - Marrero, J AU - Marrero J FAU - Venook, A AU - Venook A FAU - Ye, S-L AU - Ye SL FAU - Kudo, M AU - Kudo M LA - eng SI - ClinicalTrials.gov/NCT00812175 PT - Clinical Trial, Phase IV PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - Int J Clin Pract JT - International journal of clinical practice JID - 9712381 RN - 0 (Antineoplastic Agents) RN - 0 (Benzenesulfonates) RN - 0 (Phenylurea Compounds) RN - 0 (Pyridines) RN - 25X51I8RD4 (Niacinamide) RN - 9ZOQ3TZI87 (Sorafenib) SB - IM MH - Antineoplastic Agents/*therapeutic use MH - Benzenesulfonates/*therapeutic use MH - Carcinoma, Hepatocellular/*drug therapy MH - Clinical Trials as Topic/*methods MH - Clinical Trials, Phase IV as Topic/methods MH - Humans MH - Liver Neoplasms/*drug therapy MH - Niacinamide/analogs & derivatives MH - Patient Selection MH - Phenylurea Compounds MH - Prospective Studies MH - Pyridines/*therapeutic use MH - Research Design MH - Sorafenib MH - Treatment Outcome PMC - PMC2905618 EDAT- 2010/07/21 06:00 MHDA- 2011/11/11 06:00 CRDT- 2010/07/21 06:00 PHST- 2010/07/21 06:00 [entrez] PHST- 2010/07/21 06:00 [pubmed] PHST- 2011/11/11 06:00 [medline] AID - IJCP2414 [pii] AID - 10.1111/j.1742-1241.2010.02414.x [doi] PST - ppublish SO - Int J Clin Pract. 2010 Jul;64(8):1034-41. doi: 10.1111/j.1742-1241.2010.02414.x. PMID- 30701823 OWN - NLM STAT- MEDLINE DCOM- 20190617 LR - 20190617 IS - 0040-3660 (Print) IS - 0040-3660 (Linking) VI - 90 IP - 11 DP - 2018 Nov 22 TI - Case of iatrogenic botulism after botulinotherapy in clinical practice. PG - 102-104 LID - 10.26442/terarkh20189011102-104 [doi] AB - Injections of botulinum toxin are widely used in different medical fields, namely neurology, urology, stomatology, cosmetology, gastroenterology etc. Preparations of botulinum toxin type A (BTA) prevent the release of acetylcholine at the endings of motor nerves leading to the long-term muscle relaxation. It has been acknowledged that treatment with BTA has very good safety profile and tolerability. Extremely rare but severe complication of botulinotherapy (BT) is a condition, which is associated with generalized muscle Weakness, swallowing difficulty, respiratory arrest, and may lead to the lethal outcomes in the solitary cases. Such disorders, which present like botulism, are known as botulism-like syndrome and iatrogenic botulism. We report a clinical case of such complication in the paper. The probability of the development of such rare but severe complications necessitates certain awareness and vigilance among clinicians performing BT. FAU - Ibatullin, R A AU - Ibatullin RA AD - Bashkir State Medical University, Ufa, Bashkortostan, Russia. AD - G.G. Kuvatov Republican Clinical Hospital, Ufa, Bashkortostan, Russia. FAU - Magjanov, R V AU - Magjanov RV AD - Bashkir State Medical University, Ufa, Bashkortostan, Russia. AD - G.G. Kuvatov Republican Clinical Hospital, Ufa, Bashkortostan, Russia. LA - eng PT - Case Reports PT - Journal Article PL - Russia (Federation) TA - Ter Arkh JT - Terapevticheskii arkhiv JID - 2984818R RN - EC 3.4.24.69 (Botulinum Toxins, Type A) SB - IM MH - *Botulinum Toxins, Type A/adverse effects MH - *Botulism/etiology MH - Humans MH - *Iatrogenic Disease MH - *Respiratory Insufficiency MH - Syndrome OTO - NOTNLM OT - botulinotherapy OT - botulism-like syndrome OT - complications OT - iatrogenic botulism EDAT- 2019/02/01 06:00 MHDA- 2019/06/18 06:00 CRDT- 2019/02/01 06:00 PHST- 2019/02/01 06:00 [entrez] PHST- 2019/02/01 06:00 [pubmed] PHST- 2019/06/18 06:00 [medline] AID - 10.26442/terarkh20189011102-104 [doi] PST - ppublish SO - Ter Arkh. 2018 Nov 22;90(11):102-104. doi: 10.26442/terarkh20189011102-104. PMID- 23706127 OWN - NLM STAT- MEDLINE DCOM- 20140226 LR - 20130701 IS - 1557-9034 (Electronic) IS - 1092-6429 (Linking) VI - 23 IP - 7 DP - 2013 Jul TI - Robotic resection of benign neck masses via a retroauricular approach. PG - 578-83 LID - 10.1089/lap.2012.0468 [doi] AB - OBJECTIVES: The purpose of this study was to analyze the feasibility and safety of robotic resection of benign upper neck masses through a modified facelift approach. PATIENTS AND METHODS: Between November 2010 and February 2012, 9 patients were enrolled in this prospective study. Six patients received a robotic submandibular gland resection via a retroauricular approach. Two patients received robotic resection of the second branchial cleft cyst. One patient received robotic operation for the removal of lymphadenopathy, which occurred in the submental area. RESULTS: Robotic resection of a benign upper neck mass was successfully performed through a retroauricular approach in all patients. The average robotic system docking times and robotic operation times were 8.5 minutes and 62.4 minutes, respectively. All patients were extremely satisfied with their cosmetic results after the operation. There were no cases of nerve palsy in the marginal mandibular branch of the facial nerve, the lingual nerve, the hypoglossal nerve, or the spinal accessory nerve. No patient required blood transfusion in response to significant bleeding or was converted to open surgery. Mean blood loss was minimal (6.6 mL). The average period of follow-up for the patients was 12.7 months. All patients have maintained disease-free status. CONCLUSIONS: Robotic resection of a benign upper neck mass via a retroauricular approach is technically feasible and results in better cosmetic outcomes than the conventional transcervical approach. This new surgical method is safe and effective for benign upper neck masses that require surgical removal. FAU - Park, Young Min AU - Park YM AD - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea. FAU - Byeon, Hyung Kwon AU - Byeon HK FAU - Chung, Hyun Pil AU - Chung HP FAU - Rho, Kyung Jin AU - Rho KJ FAU - Kim, Se-Heon AU - Kim SH LA - eng PT - Journal Article DEP - 20130525 PL - United States TA - J Laparoendosc Adv Surg Tech A JT - Journal of laparoendoscopic & advanced surgical techniques. Part A JID - 9706293 SB - IM MH - Adolescent MH - Adult MH - Blood Loss, Surgical MH - Branchioma/*surgery MH - Esthetics MH - Feasibility Studies MH - Female MH - Humans MH - Lymph Node Excision/*methods MH - Male MH - Middle Aged MH - Neck/*surgery MH - Operative Time MH - Patient Safety MH - Prospective Studies MH - *Robotics MH - Submandibular Gland/*surgery MH - Treatment Outcome EDAT- 2013/05/28 06:00 MHDA- 2014/02/27 06:00 CRDT- 2013/05/28 06:00 PHST- 2013/05/28 06:00 [entrez] PHST- 2013/05/28 06:00 [pubmed] PHST- 2014/02/27 06:00 [medline] AID - 10.1089/lap.2012.0468 [doi] PST - ppublish SO - J Laparoendosc Adv Surg Tech A. 2013 Jul;23(7):578-83. doi: 10.1089/lap.2012.0468. Epub 2013 May 25. PMID- 35438949 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240923 IS - 2563-6316 (Electronic) IS - 2563-6316 (Linking) VI - 3 IP - 2 DP - 2022 Apr-Jun TI - Modeling Years of Life Lost Due to COVID-19, Socioeconomic Status, and Nonpharmaceutical Interventions: Development of a Prediction Model. PG - e30144 LID - 10.2196/30144 [doi] LID - e30144 AB - BACKGROUND: Research in the COVID-19 pandemic focused on the health burden, thereby largely neglecting the potential harm to life from welfare losses. OBJECTIVE: This paper develops a model that compares the years of life lost (YLL) due to COVID-19 and the potential YLL due to the socioeconomic consequences of its containment. METHODS: It improves on existing estimates by conceptually disentangling YLL due to COVID-19 and socioeconomic status. By reconciling the normative life table approach with socioeconomic differences in life expectancy, it accounts for the fact that people with low socioeconomic status are hit particularly hard by the pandemic. The model also draws on estimates of socioeconomic differences in life expectancy to ascertain potential YLL due to income loss, school closures, and extreme poverty. RESULTS: Tentative results suggest that if only one-tenth of the current socioeconomic damage becomes permanent in the future, it may carry a higher YLL burden than COVID-19 in the more likely pandemic scenarios. The model further suggests that the socioeconomic harm outweighs the disease burden due to COVID-19 more quickly in poorer and more unequal societies. Most urgently, the substantial increase in extreme poverty needs immediate attention. Avoiding a relatively minor number of 4 million unemployed, 1 million extremely poor, and 2 million students with a higher learning loss may save a similar amount of life years as saving 1 million people from dying from COVID-19. CONCLUSIONS: Primarily, the results illustrate the urgent need for redistributive policy interventions and global solidarity. In addition, the potentially high YLL burden from income and learning losses raises the burden of proof for the efficacy and necessity of school and business closures in the containment of the pandemic, especially where social safety nets are underdeveloped. CI - ©Jari John. Originally published in JMIRx Med (https://med.jmirx.org), 12.04.2022. FAU - John, Jari AU - John J AUID- ORCID: 0000-0002-1666-1546 AD - Institute of Political Science University of Heidelberg Heidelberg Germany. LA - eng PT - Journal Article DEP - 20220412 PL - Canada TA - JMIRx Med JT - JMIRx med JID - 101776650 UOF - https://www.medrxiv.org/content/10.1101/2021.04.23.21256005v1 UOF - JMIRx Med. 1:e30144. PMC - PMC9007225 OTO - NOTNLM OT - COVID-19 OT - income groups OT - life expectancy OT - low-income status OT - mortality OT - nonpharmaceutical interventions OT - pandemic OT - prediction model OT - public health OT - socioeconomic status COIS- Conflicts of Interest: None declared. EDAT- 2022/04/20 06:00 MHDA- 2022/04/20 06:01 PMCR- 2022/04/12 CRDT- 2022/04/19 17:02 PHST- 2021/05/03 00:00 [received] PHST- 2021/09/16 00:00 [revised] PHST- 2021/12/31 00:00 [accepted] PHST- 2022/04/19 17:02 [entrez] PHST- 2022/04/20 06:00 [pubmed] PHST- 2022/04/20 06:01 [medline] PHST- 2022/04/12 00:00 [pmc-release] AID - v3i2e30144 [pii] AID - 10.2196/30144 [doi] PST - epublish SO - JMIRx Med. 2022 Apr 12;3(2):e30144. doi: 10.2196/30144. eCollection 2022 Apr-Jun. PMID- 31013609 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 8 IP - 4 DP - 2019 Apr 22 TI - Quality Characteristics Analysis and Remaining Shelf Life Prediction of Fresh Tibetan Tricholoma matsutake under Modified Atmosphere Packaging in Cold Chain. LID - 10.3390/foods8040136 [doi] LID - 136 AB - Tricholoma matsutake (T. matsutake) growing in Tibet is very popular for its high economic and medicinal value, but fresh T. matsutake has an extremely short shelf life. The shelf life of T. matsutake is complex, influenced by product characteristics, surrounding environmental conditions, and spoilage development. The objective of this work was to study the quality characteristics of fresh T. matsutake during its shelf life period in modified atmosphere packaging (MAP) conditions and establish its remaining shelf life prediction models in a cold chain. In this study, we measured and analyzed quality indicators of fresh T. matsutake, including hardness (cap, stipe), color, odor of sensory characteristics, pH, soluble solids content (SSC), and moisture content (MC) of physical and chemical characteristics under the temperature condition of 4 °C and relative humidity (RH) of 90%. The sensory evaluation results showed that the odor indicator in sensory characteristics was more sensitive to the freshness of T. matsutake. The changes of pH, SSC, and MC were divided into three periods to analyze the physiological changes of T. matsutake. The cap spread process could affect the changes of pH, SSC, and MC in period S(1), and they changed gradually in period S(2). In the period S(3), they changed complicatedly because of deterioration. The remaining shelf life prediction model of T. matsutake was established by the back propagation (BP) neural network method to quantify the relationship between the quality indicators and the remaining shelf life. The shelf life characteristics are complex, which were optimized by correlation analysis. Significant benefits of this work are anticipated on the transportation and preservation of fresh T. matsutake to the market and the reduction of its losses in the postharvest chain. FAU - Fu, Zetian AU - Fu Z AD - Beijing Laboratory of Food Quality and Safety, College of engineering, China Agricultural University, Beijing 100083, China. fzt@cau.edu.cn. FAU - Zhao, Shuang AU - Zhao S AD - Beijing Laboratory of Food Quality and Safety, College of engineering, China Agricultural University, Beijing 100083, China. zhaosh@cau.edu.cn. FAU - Zhang, Xiaoshuan AU - Zhang X AD - Beijing Laboratory of Food Quality and Safety, College of engineering, China Agricultural University, Beijing 100083, China. zhxshuan@cau.edu.cn. FAU - Polovka, Martin AU - Polovka M AD - National Agricultural and Food Centre Priemyselná, Radlinského 9, SK-81237, Slovak Republic. polovka@vup.sk. FAU - Wang, Xiang AU - Wang X AD - Beijing Laboratory of Food Quality and Safety, College of engineering, China Agricultural University, Beijing 100083, China. wxzrjj@cau.edu.cn. LA - eng GR - 31460421/National Natural Science Foundation of China/ PT - Journal Article DEP - 20190422 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC6518299 OTO - NOTNLM OT - Tibetan T. matsutake OT - cold chain OT - modified atmosphere packaging OT - quality characteristics OT - shelf life COIS- The authors declare no conflict of interest. EDAT- 2019/04/25 06:00 MHDA- 2019/04/25 06:01 PMCR- 2019/04/22 CRDT- 2019/04/25 06:00 PHST- 2019/03/23 00:00 [received] PHST- 2019/04/10 00:00 [revised] PHST- 2019/04/16 00:00 [accepted] PHST- 2019/04/25 06:00 [entrez] PHST- 2019/04/25 06:00 [pubmed] PHST- 2019/04/25 06:01 [medline] PHST- 2019/04/22 00:00 [pmc-release] AID - foods8040136 [pii] AID - foods-08-00136 [pii] AID - 10.3390/foods8040136 [doi] PST - epublish SO - Foods. 2019 Apr 22;8(4):136. doi: 10.3390/foods8040136. PMID- 11071428 OWN - NLM STAT- MEDLINE DCOM- 20010322 LR - 20191104 IS - 1529-8663 (Print) IS - 1529-8663 (Linking) VI - 61 IP - 5 DP - 2000 Sep-Oct TI - Release of lead-containing particles from a wall enclosure. PG - 743-52 AB - The 1995 Department of Housing and Urban Development (HUD) Guidelines for the Evaluation and Control of Lead-Based Paint Hazards in Housing discusses using interior and exterior wall enclosures for lead hazard control. Leaded dust may be aerosolized inside enclosures and released through gaps and cracks into a room. The effects of airflow and mechanical disturbances on dust release were studied using a laboratory wall enclosure model with dust collected from homes with lead-based paint hazards. Airflows relevant to residences were blown down the enclosure and out a 4-, 6-, or 8-mm horizontal gap at its bottom, simulating potential enclosure failure. Then, low-frequency mechanical vibrations also were applied to the enclosure. No significant dust release was found when blowing air down the enclosure even at 37 cm/sec (representing extremely high flow); release occurred only with this high flow and 3 Hz mechanical disturbances. Dust was released primarily from the floor area immediately adjacent to the enclosure gap; the release rate fluctuated over time. Most dust initially settled near the enclosure. Dust release for 1 hour at extreme conditions (high airflow with vibration) yields lead loading above the 1995 HUD clearance level of 100 microg/ft2 only within 3-4 cm of the wall; for the HUD standard (1 ft2) sampling area, the lead loading does not exceed 30 microg/ ft2. Redistributing dust over the room's 16 m2 floor space yields average extreme-condition loading rate of 2 microg/ft2/hour. At less-than-extreme conditions, dust would have to be released for years without cleaning to yield a hazard. FAU - Harney, J AU - Harney J AD - Department of Environmental Health, University of Cincinnati, OH 45267-0056, USA. FAU - Trunov, M AU - Trunov M FAU - Grinshpun, S AU - Grinshpun S FAU - Willeke, K AU - Willeke K FAU - Choe, K AU - Choe K FAU - Trakumas, S AU - Trakumas S FAU - Friedman, W AU - Friedman W LA - eng GR - T42/CCT510420/CT/CIT NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - AIHAJ JT - AIHAJ : a journal for the science of occupational and environmental health and safety JID - 100939625 RN - 0 (Dust) RN - 2P299V784P (Lead) SB - IM MH - Dust/*analysis MH - Humans MH - Lead/*analysis MH - Paint/*analysis MH - Particle Size MH - Safety Management/*standards EDAT- 2000/11/09 11:00 MHDA- 2001/03/27 10:01 CRDT- 2000/11/09 11:00 PHST- 2000/11/09 11:00 [pubmed] PHST- 2001/03/27 10:01 [medline] PHST- 2000/11/09 11:00 [entrez] AID - 10.1080/15298660008984586 [doi] PST - ppublish SO - AIHAJ. 2000 Sep-Oct;61(5):743-52. doi: 10.1080/15298660008984586. PMID- 38292312 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240201 IS - 2215-0161 (Print) IS - 2215-0161 (Electronic) IS - 2215-0161 (Linking) VI - 12 DP - 2024 Jun TI - Anomaly-informed remaining useful life estimation (AIRULE) of bearing machinery using deep learning framework. PG - 102555 LID - 10.1016/j.mex.2024.102555 [doi] LID - 102555 AB - A rolling bearing is a crucial element within rotating machinery, and its smooth operation profoundly influences the overall well-being of the equipment. Consequently, analyzing its operational condition is crucial to prevent production losses or, in extreme cases, potential fatalities due to catastrophic failures. Accurate estimates of the Remaining Useful Life (RUL) of rolling bearings ensure manufacturing safety while also leading to cost savings.•This paper proposes an intelligent deep learning-based framework for remaining useful life estimation of bearings on the basis of informed detection of anomalies.•The paper demonstrates the setup of an experimental bearing test rig and the collection of bearing condition monitoring data such as vibration data.•Advanced hybrid models of Encoder-Decoder LSTM demonstrate high forecasting accuracy in RUL estimation. CI - © 2024 The Authors. Published by Elsevier B.V. FAU - Kamat, Pooja AU - Kamat P AD - Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. FAU - Kumar, Satish AU - Kumar S AD - Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. AD - Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. FAU - Patil, Shruti AU - Patil S AD - Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. AD - Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. FAU - Kotecha, Ketan AU - Kotecha K AD - Symbiosis Institute of Technology, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. AD - Symbiosis Centre for Applied Artificial Intelligence, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India. LA - eng PT - Journal Article DEP - 20240105 PL - Netherlands TA - MethodsX JT - MethodsX JID - 101639829 PMC - PMC10825678 OTO - NOTNLM OT - Anomaly detection OT - Anomaly-Informed Remaining Useful Life Estimation (AIRULE) using Hybrid LSTM models OT - Autoencoder: LSTM OT - Bearings OT - Remaining useful life COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/01/31 06:43 MHDA- 2024/01/31 06:44 PMCR- 2024/01/05 CRDT- 2024/01/31 04:09 PHST- 2023/10/20 00:00 [received] PHST- 2024/01/04 00:00 [accepted] PHST- 2024/01/31 06:44 [medline] PHST- 2024/01/31 06:43 [pubmed] PHST- 2024/01/31 04:09 [entrez] PHST- 2024/01/05 00:00 [pmc-release] AID - S2215-0161(24)00010-4 [pii] AID - 102555 [pii] AID - 10.1016/j.mex.2024.102555 [doi] PST - epublish SO - MethodsX. 2024 Jan 5;12:102555. doi: 10.1016/j.mex.2024.102555. eCollection 2024 Jun. PMID- 30021760 OWN - NLM STAT- MEDLINE DCOM- 20190909 LR - 20210512 IS - 1539-7262 (Electronic) IS - 0022-2275 (Print) IS - 0022-2275 (Linking) VI - 59 IP - 9 DP - 2018 Sep TI - Efficacy of two vitamin E formulations in patients with abetalipoproteinemia and chylomicron retention disease. PG - 1640-1648 LID - S0022-2275(20)33533-1 [pii] LID - 10.1194/jlr.M085043 [doi] AB - Abetalipoproteinemia (ABL) and chylomicron retention disease (CMRD) are extremely rare recessive forms of hypobetalipoproteinemia characterized by intestinal lipid malabsorption and severe vitamin E deficiency. Vitamin E is often supplemented in the form of fat-soluble vitamin E acetate, but fat malabsorption considerably limits correction of the deficiency. In this crossover study, we administered two different forms of vitamin E, tocofersolan (a water-soluble derivative of RRR-α-tocopherol) and α-tocopherol acetate, to three patients with ABL and four patients with CMRD. The aims of this study were to evaluate the intestinal absorption characteristics of tocofersolan versus α-tocopherol acetate by measuring the plasma concentrations of α-tocopherol over time after a single oral load and to compare efficacy by evaluating the ability of each formulation to restore vitamin E storage after 4 months of treatment. In patients with ABL, tocofersolan and α-tocopherol acetate bioavailabilities were extremely low (2.8% and 3.1%, respectively). In contrast, bioavailabilities were higher in patients with CMRD (tocofersolan, 24.7%; α-tocopherol acetate, 11.4%). Plasma concentrations of α-tocopherol at 4 months were not significantly different by formulation type in ABL or CMRD. This study provides new insights about vitamin E status in ABL and CMRD and suggests the potential of different formulations as treatment options. CI - Copyright © 2018 Cuerq et al. FAU - Cuerq, Charlotte AU - Cuerq C AD - Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France; INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Henin, Emilie AU - Henin E AD - Calvagone, Liergues, France. FAU - Restier, Lioara AU - Restier L AD - Pediatric Hepato-Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant de Lyon, Dyslipidemia Unity Hospices Civils de Lyon, Lyon, Bron, France. FAU - Blond, Emilie AU - Blond E AD - Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France; INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Drai, Jocelyne AU - Drai J AD - Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France; INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Marçais, Christophe AU - Marçais C AD - Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France; INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Di Filippo, Mathilde AU - Di Filippo M AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Department of Biochemistry and Molecular Biology, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, Bron, France. FAU - Laveille, Christian AU - Laveille C AD - Calvagone, Liergues, France. FAU - Michalski, Marie-Caroline AU - Michalski MC AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Poinsot, Pierre AU - Poinsot P AD - Pediatric Hepato-Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant de Lyon, Dyslipidemia Unity Hospices Civils de Lyon, Lyon, Bron, France. FAU - Caussy, Cyrielle AU - Caussy C AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France. FAU - Sassolas, Agnès AU - Sassolas A AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Department of Biochemistry and Molecular Biology, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, Bron, France. FAU - Moulin, Philippe AU - Moulin P AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Fédération d'Endocrinologie, Maladies Métaboliques, Diabète et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, Bron, France. FAU - Reboul, Emmanuelle AU - Reboul E AD - INRA, INSERM, Aix-Marseille University, Marseille, France. FAU - Charriere, Sybil AU - Charriere S AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Fédération d'Endocrinologie, Maladies Métaboliques, Diabète et Nutrition, Hôpital Louis Pradel, Hospices Civils de Lyon, Lyon, Bron, France. FAU - Levy, Emile AU - Levy E AD - Research Centre, CHU Sainte-Justine, and Department of Nutrition, Université de Montréal, Montréal, Québec, Canada. FAU - Lachaux, Alain AU - Lachaux A AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Pediatric Hepato-Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant de Lyon, Dyslipidemia Unity Hospices Civils de Lyon, Lyon, Bron, France. FAU - Peretti, Noël AU - Peretti N AD - INSERM U1060, INRA UMR 1397, INSA-Lyon, CarMeN Laboratory, Université Lyon 1, Lyon, France; Pediatric Hepato-Gastroenterology and Nutrition Unit, Hôpital Femme Mère Enfant de Lyon, Dyslipidemia Unity Hospices Civils de Lyon, Lyon, Bron, France. Electronic address: noel.peretti@chu-lyon.fr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180718 PL - United States TA - J Lipid Res JT - Journal of lipid research JID - 0376606 RN - 1406-18-4 (Vitamin E) RN - H4N855PNZ1 (alpha-Tocopherol) RN - O03S90U1F2 (tocophersolan) RN - Chylomicron retention disease SB - IM MH - Abetalipoproteinemia/*metabolism MH - Adult MH - Biological Availability MH - Case-Control Studies MH - Drug Compounding MH - Drug Storage MH - Female MH - Humans MH - Hypobetalipoproteinemias/*metabolism MH - Intestinal Absorption MH - Malabsorption Syndromes/*metabolism MH - Male MH - Middle Aged MH - Safety MH - Vitamin E/blood/metabolism/*pharmacokinetics MH - alpha-Tocopherol/blood/metabolism/*pharmacokinetics PMC - PMC6121919 OTO - NOTNLM OT - Anderson disease OT - absorption OT - adipose tissue OT - hypocholesterolemia OT - lipid and lipoprotein metabolism OT - metabolic disease OT - tocopherol EDAT- 2018/07/20 06:00 MHDA- 2019/09/10 06:00 PMCR- 2019/09/01 CRDT- 2018/07/20 06:00 PHST- 2018/05/28 00:00 [received] PHST- 2018/07/17 00:00 [revised] PHST- 2018/07/20 06:00 [pubmed] PHST- 2019/09/10 06:00 [medline] PHST- 2018/07/20 06:00 [entrez] PHST- 2019/09/01 00:00 [pmc-release] AID - S0022-2275(20)33533-1 [pii] AID - m085043 [pii] AID - 10.1194/jlr.M085043 [doi] PST - ppublish SO - J Lipid Res. 2018 Sep;59(9):1640-1648. doi: 10.1194/jlr.M085043. Epub 2018 Jul 18. PMID- 26415073 OWN - NLM STAT- MEDLINE DCOM- 20160824 LR - 20181202 IS - 1833-3516 (Print) IS - 1833-3516 (Linking) VI - 45 IP - 3 DP - 2015 Sep TI - On diver thermal status and susceptibility to decompression sickness. PG - 208 AB - In a recent Letter to the Editor, Clarke, et al, indicated that divers who deliberately chill themselves on a dive to reduce risk of decompression sickness (DCS) may be misinterpreting our 2007 Navy Experimental Diving Unit (NEDU) report. Indeed, we did not advocate that divers should risk hypothermia on bottom to reduce risk of DCS, nor do we dispute the authors' overall admonition to avoid diving cold unnecessarily. However, Clarke, et al, imply more generally that results of our study are not applicable to recreational or technical divers because the dives we tested were atypical of dives undertaken by such divers. We wish to clarify that our study does have implications for recreational and technical divers, implications that should not be ignored. The dives we tested were not intended to be typical of dives undertaken in any actual operational context. Instead, we chose to expose divers to temperatures at the extremes of their thermal tolerance in order to ensure that effects of diver thermal status on DCS susceptibility would be found if such effects existed. Our initial test dive profile provided appreciable time both on bottom and during decompression to allow any differential thermal effects during these two dive phases to manifest, while affording a baseline risk of DCS that could be altered by thermal effects without exposing subjects to inordinately high risks of DCS. Our results strongly indicate that the optimal diver thermal conditions for mitigation of DCS risk or minimization of decompression time entail remaining cool during gas uptake phases of a dive and warm during off-gassing phases. While the dose-response characteristics of our observed thermal effects are almost certainly non-linear in both exposure temperature and duration, it is only reasonable to presume that the effects vary monotonically with these factors. We have no reason to presume that such responses and effects under less extreme conditions would be in directions opposite to those found under the conditions we tested. Similarly, responses to thermal exposures even more extreme than we tested might not be larger than the responses we observed, but it would be unwise to ignore the trends in our results under some unfounded presumption that the effects reverse with changes in thermal conditions beyond those tested. Finally, thermal effects on bottom and during decompression in dives to depths other than the 120 feet of sea water (fsw) or 150 fsw depths of the dives we tested are unlikely to be qualitatively different from those observed in our tested dives. The original question has therefore been answered: chill on bottom decreases DCS susceptibility while chill during decompression increases DCS susceptibility. Under conditions encountered by recreational or technical divers, the only open issue is arguably magnitudes of effects, not directions. Neither does lack of technology to control thermal status during a dive render our study results inapplicable. It only renders the diver unable to actively optimize his or her thermal exposure to minimize DCS risk or decompression obligation. Effects of diver thermal status on bottom hold regardless of whether the dive has a decompression long enough for a thermal effect to manifest in the decompression phase of the dive. We pointed out that US Navy decompression tables have historically been developed and validated with test dives in which divers were cold and working during bottom phases and cold and resting during decompression phases. Thus, our results indicate that it is not prudent for very warm divers to challenge the US Navy no-stop limits. However, becoming deliberately chilled on bottom only to remain cold during any ensuing decompression stops is similarly ill-advised. We agree with Clarke et al. that relative conservatism of some dive computer algorithms or alternative decompression tables, or the depth and time roundups necessary to determine table-based prescriptions, work in the diver's favour, but note that diving any profile to a shorter bottom time is a ready means to reduce the risk of DCS - i.e., enhance safety - without compromising comfort. Any active diver heating is best limited while on bottom to a minimal level required to safely complete on-bottom tasks, and dialled up only during decompression. Diver warming during decompression should not be so aggressive as to risk heat stress, and care should be taken to ensure that divers remain hydrated. FAU - Gerth, Wayne A AU - Gerth WA AD - US Navy Experimental Diving Unit, Panama City, Florida, USA, E-mail: wayne.a.gerth@navy.mil. LA - eng PT - Comment PT - Letter PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 SB - IM CON - Diving Hyperb Med. 2015 Mar;45(1):62. PMID: 25964043 MH - Cold Temperature MH - Decompression MH - *Decompression Sickness MH - *Diving MH - Temperature OTO - NOTNLM OT - Decompression sickness OT - hypothermia OT - letters (to the Editor) OT - risk factors EDAT- 2015/09/29 06:00 MHDA- 2016/08/25 06:00 CRDT- 2015/09/29 06:00 PHST- 2015/09/29 06:00 [entrez] PHST- 2015/09/29 06:00 [pubmed] PHST- 2016/08/25 06:00 [medline] PST - ppublish SO - Diving Hyperb Med. 2015 Sep;45(3):208. PMID- 20604470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100707 LR - 20211020 IS - 0042-9686 (Print) IS - 0042-9686 (Linking) VI - 67 Suppl IP - Suppl DP - 1989 TI - Physiological development of the infant and its implications for complementary feeding. PG - 55-67 AB - From the standpoint of nutritional needs, physiological maturation, and immunological safety the provision of foods other than breast milk before about four months of age is unnecessary and may also be harmful. On the other hand, many infants require some complementary feeding by about six months of age. There are a number of known disadvantages and risks involved in too early complementary feeding, including interference with the infant's feeding behaviour, reduced breast-milk production, decreased iron absorption from breast milk, increased risk of infections and allergy in infants, and increased risk of a new pregnancy. With many complementary foods, including undiluted cow's milk, there is also a risk of a water deficit with a resultant hyperosmolarity and hypernatraemia that, in extreme cases, can lead to lethargy, convulsions, and even residual brain damage. Other possible implications include the development of obesity, hypertension, and arteriosclerosis in later life. The decision about when to start complementary feeding depends not only on age but also on the developmental stage of the individual infant, the type of food available, the sanitary conditions in which the food is prepared and given, and family history of atopic disease. LA - eng PT - Journal Article PL - Switzerland TA - Bull World Health Organ JT - Bulletin of the World Health Organization JID - 7507052 PMC - PMC2491195 EDAT- 1989/01/01 00:00 MHDA- 1989/01/01 00:01 PMCR- 1989/01/01 CRDT- 2010/07/07 06:00 PHST- 2010/07/07 06:00 [entrez] PHST- 1989/01/01 00:00 [pubmed] PHST- 1989/01/01 00:01 [medline] PHST- 1989/01/01 00:00 [pmc-release] PST - ppublish SO - Bull World Health Organ. 1989;67 Suppl(Suppl):55-67. PMID- 23028639 OWN - NLM STAT- MEDLINE DCOM- 20130305 LR - 20211021 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 7 IP - 9 DP - 2012 TI - Artificial regulation of water level and its effect on aquatic macrophyte distribution in Taihu Lake. PG - e44836 LID - 10.1371/journal.pone.0044836 [doi] LID - e44836 AB - Management of water levels for flood control, water quality, and water safety purposes has become a priority for many lakes worldwide. However, the effects of water level management on the distribution and composition of aquatic vegetation has received little attention. Relevant studies have used either limited short-term or discrete long-term data and thus are either narrowly applicable or easily confounded by the effects of other environmental factors. We developed classification tree models using ground surveys combined with 52 remotely sensed images (15-30 m resolution) to map the distributions of two groups of aquatic vegetation in Taihu Lake, China from 1989-2010. Type 1 vegetation included emergent, floating, and floating-leaf plants, whereas Type 2 consisted of submerged vegetation. We sought to identify both inter- and intra-annual dynamics of water level and corresponding dynamics in the aquatic vegetation. Water levels in the ten-year period from 2000-2010 were 0.06-0.21 m lower from July to September (wet season) and 0.22-0.27 m higher from December to March (dry season) than in the 1989-1999 period. Average intra-annual variation (CV(a)) decreased from 10.21% in 1989-1999 to 5.41% in 2000-2010. The areas of both Type 1 and Type 2 vegetation increased substantially in 2000-2010 relative to 1989-1999. Neither annual average water level nor CV(a) influenced aquatic vegetation area, but water level from January to March had significant positive and negative correlations, respectively, with areas of Type 1 and Type 2 vegetation. Our findings revealed problems with the current management of water levels in Taihu Lake. To restore Taihu Lake to its original state of submerged vegetation dominance, water levels in the dry season should be lowered to better approximate natural conditions and reinstate the high variability (i.e., greater extremes) that was present historically. FAU - Zhao, Dehua AU - Zhao D AD - Department of Biological Science and Technology, Nanjing University, Nanjing, China. dhzhao@nju.edu.cn FAU - Jiang, Hao AU - Jiang H FAU - Cai, Ying AU - Cai Y FAU - An, Shuqing AU - An S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120918 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 059QF0KO0R (Water) SB - IM MH - Aquatic Organisms/*growth & development MH - China MH - Environmental Policy MH - Lakes/*chemistry MH - *Plant Development MH - Seasons MH - Time Factors MH - Water/*analysis PMC - PMC3445588 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2012/10/03 06:00 MHDA- 2013/03/06 06:00 PMCR- 2012/09/18 CRDT- 2012/10/03 06:00 PHST- 2012/05/02 00:00 [received] PHST- 2012/08/13 00:00 [accepted] PHST- 2012/10/03 06:00 [entrez] PHST- 2012/10/03 06:00 [pubmed] PHST- 2013/03/06 06:00 [medline] PHST- 2012/09/18 00:00 [pmc-release] AID - PONE-D-12-12697 [pii] AID - 10.1371/journal.pone.0044836 [doi] PST - ppublish SO - PLoS One. 2012;7(9):e44836. doi: 10.1371/journal.pone.0044836. Epub 2012 Sep 18. PMID- 26348927 OWN - NLM STAT- MEDLINE DCOM- 20160616 LR - 20181113 IS - 2326-5108 (Electronic) IS - 2326-5094 (Print) IS - 2326-5094 (Linking) VI - 13 IP - 5 DP - 2015 Sep-Oct TI - The Role of a National Biocontainment Laboratory in Emergencies. PG - 345-8 LID - 10.1089/hs.2015.0023 [doi] AB - Over a decade ago, the National Institutes of Health awarded partial support for the construction and operation of 2 National Biocontainment Laboratories, with the condition that they would be available to assist in the event of public health emergencies-although how a biocontainment facility located on an academic campus might contribute was not defined. Here we offer examples of how one of these laboratories has contributed to a coordinated response to 2 recent international public health emergencies. Essential assets for success include highly trained and experienced staff, access to reference pathogens and reagents, cutting-edge knowledge of the field, appropriate biocontainment facilities, robust biosafety and biosecurity programs, and availability of modern instrumentation. The ability to marry the strengths of academia in basic and applied research with access to appropriate biocontainment facilities while drawing on a highly skilled cadre of experienced experts has proven extremely valuable in the response to recent national emergencies and will continue to do so in the future. Areas where additional planning and preparation are needed have also been identified through these experiences. FAU - Le Duc, James W AU - Le Duc JW FAU - Ksiazek, Thomas G AU - Ksiazek TG LA - eng GR - 5UC7AI094660/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20150908 PL - United States TA - Health Secur JT - Health security JID - 101654694 SB - IM MH - Communicable Diseases, Emerging/diagnosis MH - *Containment of Biohazards MH - Disaster Planning/*methods MH - *Emergencies MH - Humans MH - *Laboratories MH - Medical Laboratory Personnel/education MH - National Institutes of Health (U.S.) MH - United States PMC - PMC4582681 EDAT- 2015/09/09 06:00 MHDA- 2016/06/17 06:00 PMCR- 2016/09/01 CRDT- 2015/09/09 06:00 PHST- 2015/09/09 06:00 [entrez] PHST- 2015/09/09 06:00 [pubmed] PHST- 2016/06/17 06:00 [medline] PHST- 2016/09/01 00:00 [pmc-release] AID - 10.1089/hs.2015.0023 [pii] AID - 10.1089/hs.2015.0023 [doi] PST - ppublish SO - Health Secur. 2015 Sep-Oct;13(5):345-8. doi: 10.1089/hs.2015.0023. Epub 2015 Sep 8. PMID- 19384165 OWN - NLM STAT- MEDLINE DCOM- 20090514 LR - 20211203 IS - 1534-6080 (Electronic) IS - 0041-1337 (Print) IS - 0041-1337 (Linking) VI - 87 IP - 8 DP - 2009 Apr 27 TI - Increasing utilization of human T-cell lymphotropic virus (+) donors in liver transplantation: is it safe? PG - 1180-90 LID - 10.1097/TP.0b013e31819ebf76 [doi] AB - BACKGROUND: Liver transplantation is the best treatment option for endstage liver disease. The human T-cell lymphotrophic virus (HTLV) has been associated with leukemia/lymphoma and progressive neurologic disease. There has, however, been an increased utilization of HTLV (+) grafts with little data available to support or discourage their use. METHODS: We performed univariate and multivariate analyses related to graft and patient survival for recipients of HTLV (+) donors and compared them with recipients of HTLV (-) donors using the United Network for Organ Sharing database. Complete analysis of recipient and donor clinical and demographic factors was performed. RESULTS: There were 81 adult recipients of HTLV (+) donors and 29,747 HTLV (-) donor recipients. HTLV (+) donors were more likely to be older, women, and black, with a higher average donor risk index and creatinine, and were more likely to be shared nationally. Recipients of HTLV (+) organs were at slightly elevated risk of graft failure (HR=1.39, 95% CI 0.91-2.11) and death (HR=1.20, CI 0.71-2.02) relative to HTLV (-) donor recipients (P=0.12 and 0.5, respectively). The risk decreased after multivariate analysis - graft survival (HR=1.20, CI 0.79-1.83) and patient survival (HR=1.06, CI 0.63-1.79). CONCLUSION: Our analysis reveals no statistically significant difference in graft or patient survival between recipients of HTLV (+) and (-) donors. Serious limitations of these data are that serologic testing for HTLV has a high false positive rate and that there was a short follow-up period. Until these issues are addressed, extreme caution should be exercised when using these organs. FAU - Marvin, Michael R AU - Marvin MR AD - Department of Surgery, Division of Transplantation, University of Louisville, Louisville, KY, USA. Michael.marvin@jhsmh.org FAU - Brock, Guy N AU - Brock GN FAU - Kwarteng, Kwadwo AU - Kwarteng K FAU - Nagubandi, Ravi AU - Nagubandi R FAU - Ravindra, Kadiyala V AU - Ravindra KV FAU - Eng, Mary AU - Eng M FAU - Buell, Joseph F AU - Buell JF LA - eng GR - P30 ES014443/ES/NIEHS NIH HHS/United States GR - P30 ES014443-01A1/ES/NIEHS NIH HHS/United States GR - P30ES014443/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Transplantation JT - Transplantation JID - 0132144 SB - IM MH - Adult MH - Aged MH - Deltaretrovirus Infections/*epidemiology MH - Ethnicity MH - False Positive Reactions MH - Female MH - Graft Survival MH - Hepatitis Delta Virus MH - Humans MH - Liver Transplantation/mortality/*statistics & numerical data MH - Male MH - Middle Aged MH - Retrospective Studies MH - Safety MH - Survival Rate MH - Survivors/*statistics & numerical data MH - Tissue Donors/*statistics & numerical data MH - Tumor Virus Infections/epidemiology/mortality PMC - PMC2744350 MID - NIHMS127259 EDAT- 2009/04/23 09:00 MHDA- 2009/05/15 09:00 PMCR- 2010/04/27 CRDT- 2009/04/23 09:00 PHST- 2009/04/23 09:00 [entrez] PHST- 2009/04/23 09:00 [pubmed] PHST- 2009/05/15 09:00 [medline] PHST- 2010/04/27 00:00 [pmc-release] AID - 00007890-200904270-00013 [pii] AID - 10.1097/TP.0b013e31819ebf76 [doi] PST - ppublish SO - Transplantation. 2009 Apr 27;87(8):1180-90. doi: 10.1097/TP.0b013e31819ebf76. PMID- 9876591 OWN - NLM STAT- MEDLINE DCOM- 19990201 LR - 20220330 IS - 0363-9045 (Print) IS - 0363-9045 (Linking) VI - 24 IP - 4 DP - 1998 Apr TI - Extension of the International Conference on Harmonization Tripartite Guideline for Stability Testing of New Drug Substances and Products to countries of climatic zones III and IV. PG - 313-25 AB - The International Conference on Harmonization (ICH) Tripartite Guideline "Stability Testing of New Drug Substances and Products" sets out the stability testing requirements for a registration application within the three areas of the European Union, Japan, and the United States. These areas are assigned to climatic zone II with the storage condition of 25 degrees C/60% RH. This paper describes the adjustments that are necessary to extend the guideline to countries of climatic zones III and IV. At first storage conditions were derived with 30 degrees C/35% RH for climatic zone III and 30 degrees C/70% RH for climatic zone IV. Both conditions contain a margin of safety compared to calculated and measured data in warehouses. Furthermore, they cover the extreme temperatures above 30 and 40 degrees C which may arise in these climatic zones. Six months at 40 degrees C/75% RH was fixed as storage condition for accelerated testing to assess organoleptic and physicochemical test criteria and to make predictions for chemical stability. The predictive factor is 3.3 for 30 degrees C (6 months at 40 degrees C corresponds to 20 months at 30 degrees C). Extreme temperatures which may arise during shipment are covered by the results of stress investigations (e.g., 3 months at 50 degrees C). The next adjustment is necessary for the selection of the packaging containers. They must reflect the requirements for solid, semisolid, and liquid dosage forms caused by the two storage conditions. In the evaluation the temperature difference of 10 degrees C (40-30 degrees C) instead of 15 degrees C has to be considered, which limits the preliminary shelf lives in critical cases to 18 months instead of 24 months. Finally, statement/labeling must reflect the storage conditions. All of the other basic principles for the drug substances and drug products, such as selection and number of batches, test criteria, test procedures, specifications, testing frequency, and storage period can be applied without any change. FAU - Grimm, W AU - Grimm W AD - Analytical Sciences Department, Boehringer Ingelheim Pharma Deutschland, Biberach, Germany. LA - eng PT - Congress PT - Guideline PL - England TA - Drug Dev Ind Pharm JT - Drug development and industrial pharmacy JID - 7802620 SB - IM MH - Climate MH - Drug Industry MH - Drug Labeling MH - Drug Packaging MH - *Drug Stability MH - Drug Storage MH - Humans MH - Safety MH - Temperature EDAT- 1999/01/07 00:00 MHDA- 1999/01/07 00:01 CRDT- 1999/01/07 00:00 PHST- 1999/01/07 00:00 [pubmed] PHST- 1999/01/07 00:01 [medline] PHST- 1999/01/07 00:00 [entrez] AID - 10.3109/03639049809085626 [doi] PST - ppublish SO - Drug Dev Ind Pharm. 1998 Apr;24(4):313-25. doi: 10.3109/03639049809085626. PMID- 25391689 OWN - NLM STAT- MEDLINE DCOM- 20150824 LR - 20181202 IS - 1758-4469 (Electronic) IS - 0829-318X (Linking) VI - 34 IP - 10 DP - 2014 Oct TI - Responses of gas-exchange rates and water relations to annual fluctuations of weather in three species of urban street trees. PG - 1056-68 LID - 10.1093/treephys/tpu086 [doi] AB - The frequency of extreme weather has been rising in recent years. A 3-year study of street trees was undertaken in Tokyo to determine whether: (i) street trees suffer from severe water stress in unusually hot summer; (ii) species respond differently to such climatic fluctuations; and (iii) street trees are also affected by nitrogen (N) deficiency, photoinhibition and aerosol pollution. During the study period (2010-12), midsummers of 2010 and 2012 were unusually hot (2.4-2.8 °C higher maximum temperature than the long-term mean) and dry (6-56% precipitation of the mean). In all species, street trees exhibited substantially decreased photosynthetic rate in the extremely hot summer in 2012 compared with the average summer in 2011. However, because of a more conservative stomatal regulation (stomatal closure at higher leaf water potential) in the hot summer, apparent symptoms of hydraulic failure were not observed in street trees even in 2012. Compared with Prunus × yedoensis and Zelkova serrata, Ginkgo biloba, a gymnosperm, was high in stomatal conductance and midday leaf water potential even under street conditions in the unusually hot summer, suggesting that the species had higher drought resistance than the other species and was less susceptible to urban street conditions. This lower susceptibility might be ascribed to the combination of higher soil-to-leaf hydraulic conductance and more conservative water use. Aside from meteorological conditions, N deficiency affected street trees significantly, whereas photoinhibition and aerosol pollution had little effect. The internal CO2 and δ(13)C suggested that both water and N limited the net photosynthetic rate of street trees simultaneously, but water was more limiting. From these results, we concluded that the potential risk of hydraulic failure caused by climatic extremes could be low in urban street trees in temperate regions. However, the size of the safety margin might be different between species. CI - © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Osone, Yoko AU - Osone Y AD - School of Social Information Studies, Otsuma Women's University, 2-7-1 Karakida, Tama, Tokyo 206-8540, Japan Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji, Tokyo 192-0397, Japan osone.yk@gmail.com. FAU - Kawarasaki, Satoko AU - Kawarasaki S AD - Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, Minamiosawa 1-1, Hachioji, Tokyo 192-0397, Japan. FAU - Ishida, Atsushi AU - Ishida A AD - Center for Ecological Research, Kyoto University, 2-509-3 Hirano, Otsu, Shiga 520-2113, Japan. FAU - Kikuchi, Satoshi AU - Kikuchi S AD - Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba 305-8687, Japan. FAU - Shimizu, Akari AU - Shimizu A AD - School of Social Information Studies, Otsuma Women's University, 2-7-1 Karakida, Tama, Tokyo 206-8540, Japan. FAU - Yazaki, Kenichi AU - Yazaki K AD - Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba 305-8687, Japan. FAU - Aikawa, Shin-Ichi AU - Aikawa S AD - Forestry and Forest Products Research Institute, 1 Matsunosato, Tsukuba 305-8687, Japan Japan Forest Technology Association, Chiyoda, Tokyo 102-0085, Japan. FAU - Yamaguchi, Masahiro AU - Yamaguchi M AD - Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan. FAU - Izuta, Takeshi AU - Izuta T AD - Institute of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509, Japan. FAU - Matsumoto, Genki I AU - Matsumoto GI AD - School of Social Information Studies, Otsuma Women's University, 2-7-1 Karakida, Tama, Tokyo 206-8540, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141111 PL - Canada TA - Tree Physiol JT - Tree physiology JID - 100955338 RN - 0 (Carbon Isotopes) SB - IM MH - Carbon Isotopes MH - Cities MH - Dehydration MH - Droughts MH - Ginkgo biloba/physiology MH - Hot Temperature MH - Photosynthesis MH - Plant Leaves/*physiology MH - *Plant Transpiration MH - Prunus/physiology MH - Trees/*physiology MH - Ulmaceae/physiology OTO - NOTNLM OT - carbon isotopes OT - extreme weather OT - photosynthesis OT - roadside trees OT - stomatal conductance OT - summer heat OT - water potential EDAT- 2014/11/14 06:00 MHDA- 2015/08/25 06:00 CRDT- 2014/11/14 06:00 PHST- 2014/11/14 06:00 [entrez] PHST- 2014/11/14 06:00 [pubmed] PHST- 2015/08/25 06:00 [medline] AID - tpu086 [pii] AID - 10.1093/treephys/tpu086 [doi] PST - ppublish SO - Tree Physiol. 2014 Oct;34(10):1056-68. doi: 10.1093/treephys/tpu086. Epub 2014 Nov 11. PMID- 38859216 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240611 IS - 1094-4087 (Electronic) IS - 1094-4087 (Linking) VI - 32 IP - 9 DP - 2024 Apr 22 TI - Experimental study on visual ergonomics of an aircraft cockpit considering an extremely wide range of illuminance conditions. PG - 15723-15740 LID - 10.1364/OE.514392 [doi] AB - Vision is the main way for pilots to obtain information, and good visual ergonomics are an important support for ensuring aircraft flight safety. The range of illumination changes in the light environment of the aircraft cockpit is very wide, and research on the visual ergonomics of the cockpit needs to consider various extreme lighting conditions. This study conducted visual ergonomics experiments on 15 participants in a full-scale simulated cockpit, examining the accuracy, reaction time, and subjective evaluation of visual tasks under 8 typical environmental lighting intensity levels. The experimental results show that, except for head-up display, the accuracy of visual target interpretation tasks performed by other display devices under different brightness conditions remains at a high level. And as the brightness of the display device increases, the accuracy of interpretation gradually increases, and the reaction time gradually decreases. In terms of subjective evaluation, there is a significant correlation between fuzziness, fatigue, clarity of image symbols, resolution between symbols, comfort of the image, and overall satisfaction with the image, but the correlation with environmental illumination level is relatively low. The experimental results can provide a certain theoretical basis for the design of cockpit lighting environment. FAU - Zhu, Jinchao AU - Zhu J FAU - Shi, Zeyu AU - Shi Z FAU - Zhou, Pengcheng AU - Zhou P FAU - Xu, Min AU - Xu M LA - eng PT - Journal Article PL - United States TA - Opt Express JT - Optics express JID - 101137103 SB - IM EDAT- 2024/06/11 06:42 MHDA- 2024/06/11 06:43 CRDT- 2024/06/11 01:02 PHST- 2024/06/11 06:43 [medline] PHST- 2024/06/11 06:42 [pubmed] PHST- 2024/06/11 01:02 [entrez] AID - 548984 [pii] AID - 10.1364/OE.514392 [doi] PST - ppublish SO - Opt Express. 2024 Apr 22;32(9):15723-15740. doi: 10.1364/OE.514392. PMID- 30007211 OWN - NLM STAT- MEDLINE DCOM- 20180927 LR - 20181004 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 119 DP - 2018 Oct TI - Applying a random parameters Negative Binomial Lindley model to examine multi-vehicle crashes along rural mountainous highways in Malaysia. PG - 80-90 LID - S0001-4575(18)30305-1 [pii] LID - 10.1016/j.aap.2018.07.006 [doi] AB - Road safety in rural mountainous areas is a major concern as mountainous highways represent a complex road traffic environment due to complex topology and extreme weather conditions and are associated with more severe crashes compared to crashes along roads in flatter areas. The use of crash modelling to identify crash contributing factors along rural mountainous highways suffers from limitations in data availability, particularly in developing countries like Malaysia, and related challenges due to the presence of excess zero observations. To address these challenges, the objective of this study was to develop a safety performance function for multi-vehicle crashes along rural mountainous highways in Malaysia. To overcome the data limitations, an in-depth field survey, in addition to utilization of secondary data sources, was carried out to collect relevant information including roadway geometric factors, traffic characteristics, real-time weather conditions, cross-sectional elements, roadside features, and spatial characteristics. To address heterogeneity resulting from excess zeros, three specialized modelling techniques for excess zeros including Random Parameters Negative Binomial (RPNB), Random Parameters Negative Binomial - Lindley (RPNB-L) and Random Parameters Negative Binomial - Generalized Exponential (RPNB-GE) were employed. Results showed that the RPNB-L model outperformed the other two models in terms of prediction ability and model fit. It was found that heavy rainfall at the time of crash and the presence of minor junctions along mountainous highways increase the likelihood of multi-vehicle crashes, while the presence of horizontal curves along a steep gradient, the presence of a passing lane and presence of road delineation decrease the likelihood of multi-vehicle crashes. Findings of this study have significant implications for road safety along rural mountainous highways, particularly in the context of developing countries. CI - Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved. FAU - Rusli, Rusdi AU - Rusli R AD - Queensland University of Technology (QUT), Centre for Accident Research and Road Safety - Queensland (CARRS-Q), 130 Victoria Park Road, Kelvin Grove, QLD 4059, Australia; Politeknik Sultan Mizan Zainal Abidin, Jln Paka, 23000 Dungun, Terengganu, Malaysia. Electronic address: rusdibin.rusli@hdr.qut.edu.au. FAU - Haque, Md Mazharul AU - Haque MM AD - Queensland University of Technology (QUT), Centre for Accident Research and Road Safety - Queensland (CARRS-Q), 130 Victoria Park Road, Kelvin Grove, QLD 4059, Australia; Queensland University of Technology (QUT), Civil Engineering and Built Environment, Science and Engineering Faculty, 2 George St., S Block, Room 701, Brisbane, QLD 4000, Australia. FAU - Afghari, Amir Pooyan AU - Afghari AP AD - University of Queensland (UQ), School of Civil Engineering, Faculty of Engineering, Architecture, and Information Technology, St. Lucia, QLD 4072, Australia. FAU - King, Mark AU - King M AD - Queensland University of Technology (QUT), Centre for Accident Research and Road Safety - Queensland (CARRS-Q), 130 Victoria Park Road, Kelvin Grove, QLD 4059, Australia. LA - eng PT - Journal Article DEP - 20180711 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*statistics & numerical data MH - *Automobile Driving MH - Cross-Sectional Studies MH - Developing Countries MH - *Environment Design MH - Geological Phenomena MH - Humans MH - Malaysia MH - Models, Statistical MH - Motor Vehicles MH - Probability MH - *Rain MH - Risk Factors MH - *Rural Population MH - Safety/*statistics & numerical data MH - Weather OTO - NOTNLM OT - Excess number of zeros OT - Mountainous highways OT - Multi-vehicle crashes OT - Negative Binomial Generalized Exponential OT - Negative Binomial Lindley OT - Random parameters models EDAT- 2018/07/15 06:00 MHDA- 2018/09/28 06:00 CRDT- 2018/07/15 06:00 PHST- 2018/03/05 00:00 [received] PHST- 2018/06/22 00:00 [revised] PHST- 2018/07/02 00:00 [accepted] PHST- 2018/07/15 06:00 [pubmed] PHST- 2018/09/28 06:00 [medline] PHST- 2018/07/15 06:00 [entrez] AID - S0001-4575(18)30305-1 [pii] AID - 10.1016/j.aap.2018.07.006 [doi] PST - ppublish SO - Accid Anal Prev. 2018 Oct;119:80-90. doi: 10.1016/j.aap.2018.07.006. Epub 2018 Jul 11. PMID- 12283904 OWN - PIP STAT- MEDLINE DCOM- 19910905 LR - 20081121 IS - 0970-8685 (Print) IS - 0970-8685 (Linking) VI - 17 IP - 2 DP - 1991 Apr TI - Women and AIDS. PG - 37-9 FAU - Seghal, P N AU - Seghal PN LA - eng PT - Journal Article PL - India TA - Health Millions JT - Health for the millions JID - 9879305 MH - *Acquired Immunodeficiency Syndrome MH - Asia MH - *Breast Feeding MH - *Communicable Disease Control MH - *Confidentiality MH - Delivery of Health Care MH - Developing Countries MH - Disease MH - Education MH - Ethics MH - *Evaluation Studies as Topic MH - HIV Infections MH - Health MH - Health Services MH - India MH - Infant Nutritional Physiological Phenomena MH - Nutritional Physiological Phenomena MH - *Population Characteristics MH - *Pregnancy MH - Reproduction MH - Research MH - *Sex Education MH - Virus Diseases OID - PIP: 066295 OID - POP: 00202502 OAB - In this article, Dr. P.N. Sehgal, former director of the National Institute of Communicable Diseases in Delhi, explains the steps that women need to take to protect themselves against AIDS and discusses some issues facing women who have already contracted the disease. Because of women's lack of status in the family and society, it is harder for them to ensure their safety. Women based at home often lack information on AIDS, and those women who are informed sometimes depend on their male partner for financial support, which means that they are forced to engage in unsafe sexual practices. Safer sexual practices can reduce the risk for women. Though varying in degree of safety, some safer practices include: monogamous relationships between uninfected partners; the use of condoms for all types of sexual intercourse; non-penetrative sex practices (hugging, kissing, masturbating); reducing the number of sexual partners; avoiding sex when either of the partners has open sores or any STD. Pregnant women should also receive information concerning AIDS, including: a baby born from an HIV-infected mother has a 20-40% of being infected; the risk of transmission is higher when the mother already shows signs of AIDS; and an infected baby may die within the first few years of life. the HIV transmission may occur prepartum or during birth itself, but the risk of transmission from breastfeeding is extremely low. Dr. Sehgal stresses the need for privacy and confidentiality when dealing with carriers of the disease or when carrying out HIV testing. Above all, the rights of HIV-infected people must be protected. OABL- eng OTO - PIP OT - *Acquired Immunodeficiency Syndrome OT - Asia OT - *Breast Feeding OT - *Communicable Disease Control OT - *Confidential Information OT - *Critique OT - Delivery Of Health Care OT - Developing Countries OT - Diseases OT - Education OT - Ethics OT - Health OT - Health Services OT - Hiv Infections OT - India OT - Infant Nutrition OT - Nutrition OT - *Population At Risk OT - *Pregnancy OT - Reproduction OT - Research Methodology OT - *Sex Education--women OT - Southern Asia OT - Viral Diseases GN - PIP: TJ: HEALTH FOR THE MILLIONS EDAT- 1991/04/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1991/04/01 00:00 PHST- 1991/04/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1991/04/01 00:00 [entrez] PST - ppublish SO - Health Millions. 1991 Apr;17(2):37-9. PMID- 11119071 OWN - NLM STAT- MEDLINE DCOM- 20010118 LR - 20190831 IS - 0160-564X (Print) IS - 0160-564X (Linking) VI - 24 IP - 11 DP - 2000 Nov TI - Cyclosporin A and therapeutic plasma exchange in the treatment of severe systemic lupus erythematosus. PG - 852-6 AB - Despite treatment with intensive immunosuppressive drug regimens, often the prognosis of patients suffering from systemic lupus erythematosus (SLE) is poor. Side effects such as infections and malignancies often occur. It was the aim of this trial to assess the effect of immunosuppression, in particular with cyclosporin, and the efficacy, safety, and clinical utility of intermittent treatment with therapeutic plasma exchange (TPE) in comparison to previous intensive therapy strategies using corticosteroids, azathioprine, and/or cyclophosphamide. In this prospective trial, 28 patients (24 women, 4 men, aged 36.3 +/- 11.8 years at the diagnosis of SLE) were treated for up to 10 years with drug regimens out of corticosteroids, azathioprine, and/or cyclophosphamide. Then, over a period of up to 8 years, in addition to conventional therapies, especially in active stages of the disease with extremely high concentrations of anti-DNA, anti-nuclear antibodies, and circulating immunocomplexes, TPE sessions were carried out depending on symptomatology. In addition, the patients received cyclosporin. Compared with previous treatment modalities, clinical symptoms improved more quickly and more effectively. During the study period of a mean of 5 years, corticosteroids, azathioprine, and cyclophosphamide were reduced by 40 to 100%. No severe side effects were seen. In acute stages of SLE and in forms with persistently high antibody levels, the addition of TPE sessions and cyclosporin as the basic immunosuppressive drug is mostly very effective with regard to improving clinical symptomatology. FAU - Bambauer, R AU - Bambauer R AD - Institute for Blood Purification, Homburg/Saar, Germany. FAU - Schwarze, U AU - Schwarze U FAU - Schiel, R AU - Schiel R LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Artif Organs JT - Artificial organs JID - 7802778 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Antibodies, Antinuclear) RN - 0 (Antigen-Antibody Complex) RN - 0 (Immunosuppressive Agents) RN - 83HN0GTJ6D (Cyclosporine) RN - 8N3DW7272P (Cyclophosphamide) RN - MRK240IY2L (Azathioprine) SB - IM MH - Adrenal Cortex Hormones/therapeutic use MH - Adult MH - Antibodies, Antinuclear/blood MH - Antigen-Antibody Complex/blood MH - Azathioprine/therapeutic use MH - Chi-Square Distribution MH - Combined Modality Therapy MH - Cyclophosphamide/therapeutic use MH - Cyclosporine/adverse effects/*therapeutic use MH - Female MH - Follow-Up Studies MH - Humans MH - Immunosuppressive Agents/adverse effects/*therapeutic use MH - Lupus Erythematosus, Systemic/drug therapy/physiopathology/*therapy MH - Male MH - Middle Aged MH - *Plasma Exchange/adverse effects/methods MH - Prognosis MH - Prospective Studies MH - Safety MH - Statistics, Nonparametric MH - Treatment Outcome EDAT- 2000/12/19 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/12/19 11:00 PHST- 2000/12/19 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/12/19 11:00 [entrez] AID - aor6623 [pii] AID - 10.1046/j.1525-1594.2000.06623.x [doi] PST - ppublish SO - Artif Organs. 2000 Nov;24(11):852-6. doi: 10.1046/j.1525-1594.2000.06623.x. PMID- 27790212 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 7 DP - 2016 TI - The Influence of Sporulation Conditions on the Spore Coat Protein Composition of Bacillus subtilis Spores. PG - 1636 LID - 1636 AB - Spores are of high interest to the food and health sectors because of their extreme resistance to harsh conditions, especially against heat. Earlier research has shown that spores prepared on solid agar plates have a higher heat resistance than those prepared under a liquid medium condition. It has also been shown that the more mature a spore is, the higher is its heat resistance most likely mediated, at least in part, by the progressive cross-linking of coat proteins. The current study for the first time assesses, at the proteomic level, the effect of two commonly used sporulation conditions on spore protein presence. (14)N spores prepared on solid Schaeffer's-glucose (SG) agar plates and (15)N metabolically labeled spores prepared in shake flasks containing 3-(N-morpholino) propane sulfonic acid (MOPS) buffered defined liquid medium differ in their coat protein composition as revealed by LC-FT-MS/MS analyses. The former condition mimics the industrial settings while the latter conditions mimic the routine laboratory environment wherein spores are developed. As seen previously in many studies, the spores prepared on the solid agar plates show a higher thermal resistance than the spores prepared under liquid culture conditions. The (14)N:(15)N isotopic ratio of the 1:1 mixture of the spore suspensions exposes that most of the identified inner coat and crust proteins are significantly more abundant while most of the outer coat proteins are significantly less abundant for the spores prepared on solid SG agar plates relative to the spores prepared in the liquid MOPS buffered defined medium. Sporulation condition-specific differences and variation in isotopic ratios between the tryptic peptides of expected cross-linked proteins suggest that the coat protein cross-linking may also be condition specific. Since the core dipicolinic acid content is found to be similar in both the spore populations, it appears that the difference in wet heat resistance is connected to the differences in the coat protein composition and assembly. Corroborating the proteomic analyses, electron microscopy analyses show a significantly thinner outer coat layer of the spores cultured on the solid agar medium. FAU - Abhyankar, Wishwas R AU - Abhyankar WR AD - Department of Mass Spectrometry of Bio-macromolecules, Swammerdam Institute for Life Sciences, University of AmsterdamAmsterdam, Netherlands; Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of AmsterdamAmsterdam, Netherlands. FAU - Kamphorst, Kiki AU - Kamphorst K AD - Department of Mass Spectrometry of Bio-macromolecules, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands. FAU - Swarge, Bhagyashree N AU - Swarge BN AD - Department of Mass Spectrometry of Bio-macromolecules, Swammerdam Institute for Life Sciences, University of AmsterdamAmsterdam, Netherlands; Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of AmsterdamAmsterdam, Netherlands. FAU - van Veen, Henk AU - van Veen H AD - Department of Cell Biology and Histology, Electron Microscopy Centre Amsterdam, Academic Medical Center Amsterdam, Netherlands. FAU - van der Wel, Nicole N AU - van der Wel NN AD - Department of Cell Biology and Histology, Electron Microscopy Centre Amsterdam, Academic Medical Center Amsterdam, Netherlands. FAU - Brul, Stanley AU - Brul S AD - Department of Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands. FAU - de Koster, Chris G AU - de Koster CG AD - Department of Mass Spectrometry of Bio-macromolecules, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands. FAU - de Koning, Leo J AU - de Koning LJ AD - Department of Mass Spectrometry of Bio-macromolecules, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands. LA - eng PT - Journal Article DEP - 20161013 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC5061772 OTO - NOTNLM OT - Bacillus OT - proteomics OT - quantitative proteomics OT - spores OT - sporulation conditions EDAT- 2016/10/30 06:00 MHDA- 2016/10/30 06:01 PMCR- 2016/10/13 CRDT- 2016/10/30 06:00 PHST- 2016/06/30 00:00 [received] PHST- 2016/09/30 00:00 [accepted] PHST- 2016/10/30 06:00 [pubmed] PHST- 2016/10/30 06:01 [medline] PHST- 2016/10/30 06:00 [entrez] PHST- 2016/10/13 00:00 [pmc-release] AID - 10.3389/fmicb.2016.01636 [doi] PST - epublish SO - Front Microbiol. 2016 Oct 13;7:1636. doi: 10.3389/fmicb.2016.01636. eCollection 2016. PMID- 23170964 OWN - NLM STAT- MEDLINE DCOM- 20130131 LR - 20221207 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 12 DP - 2012 Nov 21 TI - Getting better at chronic care in remote communities: study protocol for a pragmatic cluster randomised controlled of community based management. PG - 1017 LID - 10.1186/1471-2458-12-1017 [doi] AB - BACKGROUND: Prevalence and incidence of diabetes and other common comorbid conditions (hypertension, coronary heart disease, renal disease and chronic lung disease) are extremely high among Indigenous Australians. Recent measures to improve quality of preventive care in Indigenous community settings, while apparently successful at increasing screening and routine check-up rates, have shown only modest or little improvements in appropriate care such as the introduction of insulin and other scaled-up drug regimens in line with evidence-based guidelines, together with support for risk factor reduction. A new strategy is required to ensure high quality integrated family-centred care is available locally, with continuity and cultural safety, by community-based care coordinators with appropriate system supports. METHODS/DESIGN: The trial design is open parallel cluster randomised controlled trial. The objective of this pragmatic trial is to test the effectiveness of a model of health service delivery that facilitates integrated community-based, intensive chronic condition management, compared with usual care, in rural and remote Indigenous primary health care services in north Queensland. Participants are Indigenous adults (aged 18-65 years) with poorly controlled diabetes (HbA1c>=8.5) and at least one other chronic condition. The intervention is to employ an Indigenous Health Worker to case manage the care of a maximum caseload of 30 participants. The Indigenous Health Workers receive intensive clinical training initially, and throughout the study, to ensure they are competent to coordinate care for people with chronic conditions. The Indigenous Health Workers, supported by the local primary health care (PHC) team and an Indigenous Clinical Support Team, will manage care, including coordinating access to multidisciplinary team care based on best practice standards. Allocation by cluster to the intervention and control groups is by simple randomisation after participant enrolment. Participants in the control group will receive usual care, and will be wait-listed to receive a revised model of the intervention informed by the data analysis. The primary outcome is reduction in HbA1c measured at 18 months. Implementation fidelity will be monitored and a qualitative investigation (methods to be determined) will aim to identify elements of the model which may influence health outcomes for Indigenous people with chronic conditions. DISCUSSION: This pragmatic trial will test a culturally-sound family-centred model of care with supported case management by IHWs to improve outcomes for people with complex chronic care needs. This trial is now in the intervention phase. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTR12610000812099. FAU - Schmidt, Barbara AU - Schmidt B AD - Getting Better at Chronic Care Project, University of South Australia, School of Health Sciences, Cairns Diabetes Centre, 381 Sheridan St, North Cairns, QLD, 4870, Australia. barbara.schmidt@unisa.edu.au FAU - Wenitong, Mark AU - Wenitong M FAU - Esterman, Adrian AU - Esterman A FAU - Hoy, Wendy AU - Hoy W FAU - Segal, Leonie AU - Segal L FAU - Taylor, Sean AU - Taylor S FAU - Preece, Cilla AU - Preece C FAU - Sticpewich, Alex AU - Sticpewich A FAU - McDermott, Robyn AU - McDermott R LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20121121 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Glycated Hemoglobin A) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Chronic Disease MH - Cluster Analysis MH - Community Health Services/organization & administration/*standards MH - Comorbidity MH - Diabetes Mellitus, Type 2/blood/*therapy MH - Follow-Up Studies MH - Glycated Hemoglobin/analysis MH - Health Services, Indigenous/organization & administration/*standards MH - Humans MH - Long-Term Care/organization & administration/standards MH - Middle Aged MH - Models, Organizational MH - Patient-Centered Care/organization & administration/*standards MH - Quality Assurance, Health Care/*organization & administration MH - Queensland MH - Research Design MH - Rural Health Services/organization & administration/*standards MH - Treatment Outcome MH - Young Adult PMC - PMC3519682 EDAT- 2012/11/23 06:00 MHDA- 2013/02/01 06:00 PMCR- 2012/11/21 CRDT- 2012/11/23 06:00 PHST- 2012/11/05 00:00 [received] PHST- 2012/11/12 00:00 [accepted] PHST- 2012/11/23 06:00 [entrez] PHST- 2012/11/23 06:00 [pubmed] PHST- 2013/02/01 06:00 [medline] PHST- 2012/11/21 00:00 [pmc-release] AID - 1471-2458-12-1017 [pii] AID - 10.1186/1471-2458-12-1017 [doi] PST - epublish SO - BMC Public Health. 2012 Nov 21;12:1017. doi: 10.1186/1471-2458-12-1017. PMID- 23434845 OWN - NLM STAT- MEDLINE DCOM- 20130827 LR - 20130307 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 53 DP - 2013 Apr TI - The effects of age and traffic density on street-crossing behavior. PG - 166-75 LID - S0001-4575(12)00450-2 [pii] LID - 10.1016/j.aap.2012.12.028 [doi] AB - Past research has shown that road users accept shorter time gaps when the waiting time/number of vehicles they let pass before attempting to merge into the traffic increases. While elderly pedestrians are known to be an extremely vulnerable group of road users, very few studies dealt with the effect of environmental constraints and crossing complexity on this population's safety. The present study aimed at determining whether or not street-crossing decisions and behavior of younger and older pedestrians were differently affected by a traffic flow. In an interactive street-crossing task, we assessed whether mean time gap and crossing decisions depended on the position of the gap pedestrians selected into the traffic stream. Results revealed that irrespective of their age pedestrians accepted a smaller time gap when they chose the second interval of the traffic compared to the first one. Contrasting with previous hypotheses, this traffic-related behavior was not accompanied by an increase in the decisions risk. The findings also showed that the transition threshold from rejecting to accepting time gaps was shorter when the second interval was selected compared to the first one. This increment in task constraints might help younger and older pedestrians alike to perceive action possibilities more accurately and to be better attuned to traffic conditions by comparing gaps between each other. This opens an interesting perspective in the understanding and the training of the ability of elderly road users to remain accurate in their judgements. CI - Copyright © 2013. Published by Elsevier Ltd. FAU - Lobjois, Régis AU - Lobjois R AD - Laboratory for Road Operations, Perception, Simulators and Simulations, French Institute of Science and Technology for Transport, Development and Networks, France. lobjois@ifsttar.fr FAU - Benguigui, Nicolas AU - Benguigui N FAU - Cavallo, Viola AU - Cavallo V LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130110 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/prevention & control/*psychology MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Analysis of Variance MH - *Choice Behavior MH - Computer Simulation MH - *Environment MH - Female MH - Humans MH - Locomotion MH - Male MH - Middle Aged MH - Risk-Taking MH - *Safety MH - Time Factors EDAT- 2013/02/26 06:00 MHDA- 2013/08/28 06:00 CRDT- 2013/02/26 06:00 PHST- 2011/06/29 00:00 [received] PHST- 2012/11/26 00:00 [revised] PHST- 2012/12/20 00:00 [accepted] PHST- 2013/02/26 06:00 [entrez] PHST- 2013/02/26 06:00 [pubmed] PHST- 2013/08/28 06:00 [medline] AID - S0001-4575(12)00450-2 [pii] AID - 10.1016/j.aap.2012.12.028 [doi] PST - ppublish SO - Accid Anal Prev. 2013 Apr;53:166-75. doi: 10.1016/j.aap.2012.12.028. Epub 2013 Jan 10. PMID- 28739242 OWN - NLM STAT- MEDLINE DCOM- 20180517 LR - 20180517 IS - 1532-6497 (Electronic) IS - 1067-991X (Linking) VI - 36 IP - 4 DP - 2017 Jul-Aug TI - Helicopter Emergency Medical Service Simulation Training in the Extreme: Simulation-based Training in a Mountain Weather Chamber. PG - 193-194 LID - S1067-991X(17)30074-3 [pii] LID - 10.1016/j.amj.2017.03.004 [doi] AB - Mountain rescue operations often confront crews with extreme weather conditions. Extremely cold temperatures make standard treatment sometimes difficult or even impossible. It is well-known that most manual tasks, including those involved in mountain rescue operations, are slowed by extremely cold weather. To lessen and improve the decrement in performance of emergency medical treatment caused by cold-induced manual impairment and inadequate medical equipment and supplies, simulation training in a weather chamber, which can produce wind and temperatures up to -22°C, was developed. It provides a promising tool to train the management of complex multidisciplinary settings, thus reducing the occurrence of fatal human and technical errors and increasing the safety for both the patient and the mountain emergency medical service crew. CI - Copyright © 2017 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved. FAU - Pietsch, Urs AU - Pietsch U AD - Kantonsspital St Gallen Klinik für Anästhesiologie, Intensiv-, Rettungs- und Schmerzmedizin, St Gallen, Switzerland; Bergwacht Schwarzwald, Hessen, Bayern, Germany; Air Zermatt, Zermatt, Switzerland. Electronic address: urs.pietsch@kssg.ch. FAU - Ney, Ludwig AU - Ney L AD - Bergwacht Schwarzwald, Hessen, Bayern, Germany; Air Zermatt, Zermatt, Switzerland; Klinik für Anaesthesiologie, Klinikum der Universität München, München, Germany. FAU - Kreuzer, Oliver AU - Kreuzer O AD - Air Zermatt, Zermatt, Switzerland. FAU - Berner, Armin AU - Berner A AD - Bergwacht Schwarzwald, Hessen, Bayern, Germany; Air Zermatt, Zermatt, Switzerland; Abteilung für Anästhesie und operative Intensivmedizin, Klinikum Garmisch-Partenkirchen, Garmisch-Partenkirchen, Germany. FAU - Lischke, Volker AU - Lischke V AD - Bergwacht Schwarzwald, Hessen, Bayern, Germany; Air Zermatt, Zermatt, Switzerland; Hochtaunus-Kliniken gGmbH Krankenhaus Bad Homburg, Abteilung für Anästhesie und operative Intensivmedizin, Bad Homburg, Germany. LA - eng PT - Journal Article DEP - 20170421 PL - United States TA - Air Med J JT - Air medical journal JID - 9312325 MH - *Air Ambulances MH - Cold Temperature MH - *Emergency Medical Services MH - Humans MH - *Simulation Training MH - *Weather MH - Wind EDAT- 2017/07/26 06:00 MHDA- 2018/05/18 06:00 CRDT- 2017/07/26 06:00 PHST- 2017/02/26 00:00 [received] PHST- 2017/03/24 00:00 [accepted] PHST- 2017/07/26 06:00 [entrez] PHST- 2017/07/26 06:00 [pubmed] PHST- 2018/05/18 06:00 [medline] AID - S1067-991X(17)30074-3 [pii] AID - 10.1016/j.amj.2017.03.004 [doi] PST - ppublish SO - Air Med J. 2017 Jul-Aug;36(4):193-194. doi: 10.1016/j.amj.2017.03.004. Epub 2017 Apr 21. PMID- 12292543 OWN - PIP STAT- MEDLINE DCOM- 19971001 LR - 20220318 VI - 5 IP - 2 DP - 1997 Spring TI - The IUD: dispelling the myths and assessing the potential. PG - 1-4 FAU - Mishell Dr Jr AU - Mishell Dr Jr FAU - Sulak, P J AU - Sulak PJ LA - eng PT - Journal Article PL - United States TA - Dialogues Contracept JT - Dialogues in contraception JID - 101084274 MH - Americas MH - Biology MH - *Communication MH - *Contraception MH - Developed Countries MH - Disease MH - *Evaluation Studies as Topic MH - Family Planning Services MH - Health MH - Infections MH - *Intrauterine Devices MH - *Jurisprudence MH - North America MH - *Pelvic Inflammatory Disease MH - Pregnancy Complications MH - *Pregnancy, Ectopic MH - Public Health MH - *Risk Factors MH - *Safety MH - United States OID - PIP: 125702 OID - POP: 00267281 OAB - While the IUD is the most widely used method of reversible contraception throughout the rest of the world, it is used by only 1% of women in the US. Misperceptions that inhibit use of the IUD in the US include 1) the belief that the device works as an abortifacient when, in fact, the mechanism of action of copper releasing IUDs is contraceptive; 2) the belief that all IUDs increase risk of pelvic infection when, in fact, the Dalkon shield is the only IUD associated with increased risk because its multifilament tail allowed bacteria to ascend into the uterine cavity; 3) the association of IUD usage with increased risk of ectopic pregnancy despite the evidence that copper-bearing IUDs actually reduce risk of ectopic pregnancy; and 4) fears that IUD prescribers increase their legal liability although these fears can be allayed by reviewing product information with users, obtaining their informed consent to IUD use, and documenting the provision of detailed postinsertion instructions. Both the copper-releasing and the progesterone-containing IUDs provide effective contraception associated with very low pregnancy rates. Complications of use include expulsions, which occur most frequently in the first 3 months of use and are associated with young age of the women, immediate postpartum insertion, nulliparity, and the skill of the clinician. Uterine perforation upon insertion is extremely rare, and risk depends upon clinician skill. Risk of spontaneous abortion increases if IUDs are left in place during pregnancy. The main reason for discontinuation are increased menstrual bleeding and pain in users, although the progesterone IUD is associated with reduced blood loss. Discontinuation is accompanied by a rapid return to fertility. After screening IUD candidates for risk factors, insertion can occur at any time as long as pregnancy is ruled out (with postpartum insertion recommended after 4 weeks). Users should receive detailed instructions about how to check for expulsion. IUDs provide a good longterm alternative to sterilization. OABL- eng OTO - PIP OT - Americas OT - Biology OT - Communication OT - Contraception OT - *Contraceptive Effectiveness OT - Contraceptive Methods OT - *Contraceptive Mode Of Action OT - *Critique OT - Developed Countries OT - Diseases OT - Family Planning OT - Health OT - Infections OT - *Iud OT - *Literature Review OT - *Medical Liability OT - *Misinformation OT - North America OT - Northern America OT - *Pelvic Infections OT - Pregnancy Complications OT - *Pregnancy, Ectopic OT - Public Health OT - *Risk Factors OT - *Safety OT - United States GN - PIP: TJ: DIALOGUES IN CONTRACEPTION EDAT- 1997/04/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1997/04/01 00:00 PHST- 1997/04/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1997/04/01 00:00 [entrez] PST - ppublish SO - Dialogues Contracept. 1997 Spring;5(2):1-4. PMID- 8893908 OWN - NLM STAT- MEDLINE DCOM- 19970312 LR - 20071114 IS - 0954-0121 (Print) IS - 0954-0121 (Linking) VI - 8 IP - 5 DP - 1996 Oct TI - Predicting dentists' willingness to treat HIV-infected patients. PG - 581-8 AB - Access to oral health care is extremely important for those infected with HIV, because oral findings can lead to early detection and improved staging and management of HIV infection. In addition, oral lesions associated with HIV infection are often debilitating, but can be managed effectively with proper oral health care. There is ample evidence that dentists have, at times, resisted accepting HIV positive patients (PHIV+). The intent of the research project described below was to develop and test a model predicting dentists' willingness to treat PHIV+. Data were collected from a sample of dentists practising in New York City. The dependent variable was a scale constructed of items measuring willingness to treat PHIV+ under varying conditions. Independent variables were entered into a multiple linear regression equation in iterative attempts to arrive at a model predicting dentists' willingness to treat PHIV+, which was both parsimonious and had explanatory power. The final model included five independent variables measuring: (1) perceived safety; (2) willingness to treat homosexuals; (3) perceived ethical obligation to treat PHIV +; (4) past experience; and (5) perceived norms of colleagues. Perceived safety and perceived norms of colleagues had by far the most predictive power of all independent variables. R2 for the model = 0.58. FAU - Sadowsky, D AU - Sadowsky D AD - Columbia University, School of Dental and Oral Surgery, New York, NY 10032, USA. FAU - Kunzel, C AU - Kunzel C LA - eng GR - DE 10301/DE/NIDCR NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - AIDS Care JT - AIDS care JID - 8915313 SB - IM MH - Attitude of Health Personnel MH - Dental Care for Chronically Ill/psychology/*statistics & numerical data MH - Dentists/*psychology/standards/statistics & numerical data MH - Ethics, Dental MH - HIV Infections/*psychology MH - Health Services Accessibility/*statistics & numerical data MH - Homosexuality MH - Humans MH - Linear Models MH - *Models, Psychological MH - Multivariate Analysis MH - New York City MH - Refusal to Treat/*statistics & numerical data MH - Safety MH - Sampling Studies MH - Social Perception OID - NRCBL: VF 9.5.6 OTO - KIE OT - Empirical Approach OT - Health Care and Public Health OT - Professional Patient Relationship GN - KIE: 40 refs. GN - KIE: KIE Bib: AIDS/health personnel EDAT- 1996/10/01 00:00 MHDA- 1996/10/01 00:01 CRDT- 1996/10/01 00:00 PHST- 1996/10/01 00:00 [pubmed] PHST- 1996/10/01 00:01 [medline] PHST- 1996/10/01 00:00 [entrez] AID - MFJY7AGNYUAFV2PW [pii] AID - 10.1080/09540129650125533 [doi] PST - ppublish SO - AIDS Care. 1996 Oct;8(5):581-8. doi: 10.1080/09540129650125533. PMID- 12670366 OWN - NLM STAT- MEDLINE DCOM- 20031223 LR - 20191210 IS - 0042-9007 (Print) IS - 0042-9007 (Linking) VI - 84 IP - 3 DP - 2003 Apr TI - Evaluation of virus and prion reduction in a new intravenous immunoglobulin manufacturing process. PG - 176-87 AB - BACKGROUND AND OBJECTIVES: Minimizing the transmission risk of infectious diseases is of primary importance in the manufacture of products derived from human plasma. A novel chromatography-based intravenous immunoglobulin (IGIV) manufacturing process was developed and the reduction of virus and transmissible spongiform encephalopathies (TSE) during the manufacturing process was assessed. Mechanistically distinct steps that could affect virus reduction were identified, and the robustness of virus reduction over the range of process conditions was determined. MATERIALS AND METHODS: Virus and TSE reduction by processing steps were assessed using a scaled-down version of the IGIV manufacturing process. RESULTS: Virus and TSE reduction at manufacturing process set points were well within safety standards. Robustness studies verified that the reproducibility of virus reduction was maintained at or beyond operating parameter extremes. Virus reduction across two combined manufacturing steps was lower than the sum of virus-reduction values across the individual steps, indicating mechanistic similarity of the two steps with respect to virus reduction. Only reduction from mechanistically distinct steps was claimed. CONCLUSIONS: This comprehensive approach to pathogen safety provides the new immunoglobulin manufacturing process with a detailed, yet realistic, assessment of the risk of transmission of infectious pathogens. FAU - Trejo, S R AU - Trejo SR AD - Pre-Clinical Research and Pathogen Safety, Bayer Healthcare, Biological Products Division, Research Triangle Park, North Carolina, USA. FAU - Hotta, J A AU - Hotta JA FAU - Lebing, W AU - Lebing W FAU - Stenland, C AU - Stenland C FAU - Storms, R E AU - Storms RE FAU - Lee, D C AU - Lee DC FAU - Li, H AU - Li H FAU - Petteway, S AU - Petteway S FAU - Remington, K M AU - Remington KM LA - eng PT - Journal Article PT - Validation Study PL - England TA - Vox Sang JT - Vox sanguinis JID - 0413606 RN - 0 (Caprylates) RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Prions) RN - OBL58JN025 (octanoic acid) SB - IM MH - Caprylates/pharmacology MH - Chemical Precipitation MH - Chromatography MH - Disinfection/*methods/standards MH - Drug Contamination/prevention & control MH - Drug Industry/*methods/standards MH - Filtration MH - Humans MH - Immunoglobulins, Intravenous/*standards MH - Manufactured Materials/standards/virology MH - Prion Diseases/prevention & control/transmission MH - Prions/*isolation & purification MH - Virus Diseases/prevention & control/transmission MH - Viruses/*isolation & purification EDAT- 2003/04/03 05:00 MHDA- 2003/12/24 05:00 CRDT- 2003/04/03 05:00 PHST- 2003/04/03 05:00 [pubmed] PHST- 2003/12/24 05:00 [medline] PHST- 2003/04/03 05:00 [entrez] AID - 279 [pii] AID - 10.1046/j.1423-0410.2003.00279.x [doi] PST - ppublish SO - Vox Sang. 2003 Apr;84(3):176-87. doi: 10.1046/j.1423-0410.2003.00279.x. PMID- 16164984 OWN - NLM STAT- MEDLINE DCOM- 20060120 LR - 20081121 IS - 0146-6453 (Print) IS - 0146-6453 (Linking) VI - 35 IP - 1 DP - 2005 TI - Protecting people against radiation exposure in the event of a radiological attack. A report of The International Commission on Radiological Protection. PG - 1-110, iii-iv AB - This report responds to a widely perceived need for professional advice on radiological protection measures to be undertaken in the event of a radiological attack. The report, which is mainly concerned with possible attacks involving 'radioactive dispersion devices', re-affirms the applicability of existing ICRP recommendations to such situations, should they ever occur. Many aspects of the emergency scenarios expected to arise in the event of a radiological attack may be similar to those that experience has shown can arise from radiological accidents, but there may also be important differences. For instance, a radiological attack would probably be targeted at a public area, possibly in an urban environment, where the presence of radiation is not anticipated and the dispersion conditions commonly assumed for a nuclear or radiological emergency, such as at a nuclear installation, may not be applicable. First responders to a radiological attack and other rescuers need to be adequately trained and to have the proper equipment for identifying radiation and radioactive contamination, and specialists in radiological protection must be available to provide advice. It may be prudent to assume that radiological, chemical, and/or biological agents are involved in an attack until it is proven otherwise. This calls for an 'all-hazard' approach to the response. In the aftermath of an attack, the main aim of radiological protection must be to prevent the occurrence of acute health effects attributable to radiation exposure (termed 'deterministic' effects) and to restrict the likelihood of late health effects (termed 'stochastic' effects) such as cancers and some hereditable diseases. A supplementary aim is to minimise environmental contamination from radioactive residues and the subsequent general disruption of daily life. The report notes that action taken to avert exposures is a much more effective protective measure than protective measure the provision of medical treatment after exposure has occurred. Responders involved in recovery, remediation and eventual restoration should be subject to the usual international standards for occupational radiological protection, which are based on ICRP recommendations, including the relevant requirements for occupational dose limitation established in such standards. These restrictions may be relaxed for informed volunteers undertaking urgent rescue operations, and they are not applicable for voluntary life-saving actions. However, specific protection measures are recommended for female workers who may be pregnant or nursing an infant. The immediate countermeasures to protect the public in the rescue phase are primarily caring for people with traumatic injuries and controlling access. Subsequent actions include respiratory protection, personal decontamination, sheltering, iodine prophylaxis (if radio-iodines are involved), and temporary evacuation. In the recovery phase, the relocation and resettlement of people may be needed in extreme cases. This phase may require remedial action, including cleanup, management of the resulting radioactive waste, management of any human remains containing significant amounts of radioactive substances, and dealing with remaining radioactive residues. The guidance given in relation to public protection is based solely on radiological protection considerations and should be seen as a decision-aiding tool to prepare for the aftermath of a radiological attack. It is expected to serve as input to a final decision-making process that may include other societal concerns, consideration of lessons learned in the past (especially these involving the public perception of the risks posed by radioactive contamination) and the participation of interested parties. A radiological attack could also be the cause of radioactive contamination of water, food, and other widely consumed commodities. This possible outcome is considered unlikely to lead to significant internal contamination of a large number of people owing to the large amounts of radioactive material that would be required to cause high levels of contamination of water, food, and other commodities. Nonetheless, the report recommends radiological criteria for restricting the use of commodities under such circumstances. The report concludes by re-iterating that the response to radiological attacks should be planned beforehand following the customary processes for optimisation of radiological protection recommended by ICRP, and that optimised measures should be prepared in advance. Such plans should result in a systematic approach that can be modified if necessary to take into account the prevailing conditions and to invoke actions as warranted by the circumstances. Many potential scenarios clearly cannot induce immediate severe radiation injuries. Therefore, in order to prevent over-reaction, response measures prepared in advance should reflect the real expected gravity of the various possible scenarios. FAU - Valentin, J AU - Valentin J CN - International Commission on Radiological Protection LA - eng PT - Journal Article PL - England TA - Ann ICRP JT - Annals of the ICRP JID - 7708044 SB - IM MH - Environmental Exposure/analysis/*prevention & control MH - Guidelines as Topic MH - Humans MH - Internationality MH - Radiation Injuries/etiology/*prevention & control MH - Radiation Monitoring/*methods MH - Radiation Protection/*methods MH - Radioactive Hazard Release/prevention & control MH - Risk Assessment/methods/*organization & administration MH - Risk Factors MH - Safety Management/methods/*organization & administration MH - *Terrorism EDAT- 2005/09/17 09:00 MHDA- 2006/01/21 09:00 CRDT- 2005/09/17 09:00 PHST- 2005/09/17 09:00 [pubmed] PHST- 2006/01/21 09:00 [medline] PHST- 2005/09/17 09:00 [entrez] AID - S0146-6453(05)00002-3 [pii] AID - 10.1016/j.icrp.2005.01.001 [doi] PST - ppublish SO - Ann ICRP. 2005;35(1):1-110, iii-iv. doi: 10.1016/j.icrp.2005.01.001. PMID- 24824283 OWN - NLM STAT- MEDLINE DCOM- 20150804 LR - 20161125 IS - 1600-0641 (Electronic) IS - 0168-8278 (Linking) VI - 61 IP - 4 DP - 2014 Oct TI - Safe use of liver grafts from hepatitis B surface antigen positive donors in liver transplantation. PG - 809-15 LID - S0168-8278(14)00312-2 [pii] LID - 10.1016/j.jhep.2014.05.003 [doi] AB - BACKGROUND & AIMS: Liver grafts from hepatitis B surface antigen (HBsAg) positive donors could have potential to increase the donor pool. However, knowledge is extremely limited in this setting because currently available data are mostly from case reports. We aimed to assess the outcomes and experiences of liver transplantation from HBsAg positive donors in a single centre study. METHODS: From January 2010 to February 2013, 42 adult patients underwent liver transplantation from HBsAg positive donors and 327 patients from HBsAg negative ones. The outcomes including complications and survival of two groups were compared and antiviral therapy retrospectively reviewed. RESULTS: HBsAg positive liver grafts were more likely to be allocated to patients with hepatitis B (HBV)-related diseases. Post-transplant evaluation showed similar graft function regaining pace and no differences in complications such as primary non-function, acute rejection and biliary complications. Patient and graft survivals were comparable to that of HBsAg negative grafts. Furthermore, HBsAg persisted after transplant in all patients that received positive grafts. The donor HBV serum status determined the one of the recipient after transplantation. No HBV flare-ups were observed under antiviral therapy of oral nucleotide analogues, regardless of using hepatitis B immunoglobulin combination. CONCLUSIONS: Utilization of HBsAg positive liver grafts seems not to increase postoperative morbidity and mortality. Therefore it is a safe way to expand the donor pool when no suitable donor is available. Our experience also suggests that hepatitis B immunoglobulin should be abandoned in recipients of HBsAg positive liver grafts, in whom HBV prophylaxis could be the only oral antiviral therapy. CI - Copyright © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. FAU - Yu, Songfeng AU - Yu S AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Yu, Jun AU - Yu J AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Zhang, Wei AU - Zhang W AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Cheng, Longyu AU - Cheng L AD - Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Ye, Yufu AU - Ye Y AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Geng, Lei AU - Geng L AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Yu, Zhiyong AU - Yu Z AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Yan, Sheng AU - Yan S AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Wu, Lihua AU - Wu L AD - Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Wang, Weilin AU - Wang W AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. FAU - Zheng, Shusen AU - Zheng S AD - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Hangzhou, China; Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, China. Electronic address: shusenzheng@zju.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140510 PL - Netherlands TA - J Hepatol JT - Journal of hepatology JID - 8503886 RN - 0 (Antiviral Agents) RN - 0 (Hepatitis B Surface Antigens) RN - 0 (Immunoglobulins) RN - 2T8Q726O95 (Lamivudine) RN - XII270YC6M (hepatitis B hyperimmune globulin) SB - IM MH - Adult MH - Antiviral Agents/therapeutic use MH - China MH - Donor Selection/methods MH - *End Stage Liver Disease/immunology/surgery MH - Female MH - Graft Survival/immunology MH - *Hepatitis B/immunology/surgery MH - Hepatitis B Surface Antigens/*blood MH - Humans MH - Immunization, Passive/methods MH - Immunoglobulins/*therapeutic use MH - Lamivudine/*therapeutic use MH - Liver/*immunology MH - Liver Transplantation/*methods MH - Male MH - Middle Aged MH - Patient Safety MH - Retrospective Studies MH - Seroepidemiologic Studies MH - Tissue Donors MH - Transplants/immunology MH - Treatment Outcome OTO - NOTNLM OT - Antiviral therapy OT - HBsAg positive donor OT - Liver transplantation OT - Marginal graft EDAT- 2014/05/16 06:00 MHDA- 2015/08/05 06:00 CRDT- 2014/05/15 06:00 PHST- 2014/01/07 00:00 [received] PHST- 2014/05/01 00:00 [revised] PHST- 2014/05/05 00:00 [accepted] PHST- 2014/05/15 06:00 [entrez] PHST- 2014/05/16 06:00 [pubmed] PHST- 2015/08/05 06:00 [medline] AID - S0168-8278(14)00312-2 [pii] AID - 10.1016/j.jhep.2014.05.003 [doi] PST - ppublish SO - J Hepatol. 2014 Oct;61(4):809-15. doi: 10.1016/j.jhep.2014.05.003. Epub 2014 May 10. PMID- 21164406 OWN - NLM STAT- MEDLINE DCOM- 20110114 LR - 20131121 IS - 1530-0293 (Electronic) IS - 0090-3493 (Linking) VI - 38 IP - 10 Suppl DP - 2010 Oct TI - Rationale for routine and immediate administration of intravenous estrogen for all critically ill and injured patients. PG - S620-9 LID - 10.1097/CCM.0b013e3181f243a9 [doi] AB - In addition to a number of very compelling clinical observations, an extensive body of extremely supportive experimental data has generated a very persuasive argument that intravenous estrogen should be routinely administered, as soon as possible, to all persons identified as having a critical illness or injury. Although, to date, definitive gold-standard clinical trials are lacking, what has made this provocative argument even more convincing is the longstanding, documented safety of intravenous estrogen for various illnesses and conditions as well as the relative ease and inexpensive cost of treatment. As such, even routine prehospital administration becomes extremely feasible for a myriad of conditions. More importantly, the worldwide magnitude of potential patients who could benefit is profound. Even if estrogen only changes the outcome in a relatively small percentage of applicable cases, the potential impact may still be of dramatic proportions in terms of the absolute number of lives saved and the resources spared worldwide. Resources may be spared not only in terms of diminishing the economic impact of death and long-term disability, but also in terms of preventing extended intensive care unit stays and treatment of preventable complications that result in longer recovery. FAU - Wigginton, Jane G AU - Wigginton JG AD - Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas TX, USA. FAU - Pepe, Paul E AU - Pepe PE FAU - Idris, Ahamed H AU - Idris AH LA - eng GR - 5 UL1 RR024982-04/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Crit Care Med JT - Critical care medicine JID - 0355501 RN - 0 (Estrogens) RN - 3XMK78S47O (Testosterone) RN - 4G7DS2Q64Y (Progesterone) SB - IM MH - Animals MH - Brain Injuries/drug therapy MH - Brain Ischemia/drug therapy MH - Critical Care/*methods MH - Critical Illness/therapy MH - Disease Models, Animal MH - Estrogens/administration & dosage/pharmacology/*therapeutic use MH - Female MH - Heart Arrest/drug therapy MH - Humans MH - Infusions, Intravenous MH - Intracranial Hemorrhages/drug therapy MH - Male MH - Progesterone/therapeutic use MH - Rats MH - Spinal Cord Injuries/drug therapy MH - Testosterone/therapeutic use MH - Treatment Outcome MH - Wounds and Injuries/drug therapy EDAT- 2011/01/05 06:00 MHDA- 2011/01/15 06:00 CRDT- 2010/12/18 06:00 PHST- 2010/12/18 06:00 [entrez] PHST- 2011/01/05 06:00 [pubmed] PHST- 2011/01/15 06:00 [medline] AID - 00003246-201010001-00018 [pii] AID - 10.1097/CCM.0b013e3181f243a9 [doi] PST - ppublish SO - Crit Care Med. 2010 Oct;38(10 Suppl):S620-9. doi: 10.1097/CCM.0b013e3181f243a9. PMID- 27336334 OWN - NLM STAT- MEDLINE DCOM- 20160824 LR - 20160624 IS - 1027-6661 (Print) IS - 1027-6661 (Linking) VI - 22 IP - 2 DP - 2016 TI - [Surgical safety cheklist at the management of the hybrid operating room]. PG - 54-9 AB - An essential aspect of the work of the operating room is the provision of safety of both the patient and staff. The organization of the activity of the surgical service requires serious elaboration of each of its stage, as well as standardization in using various validated instruments. When speaking of a hybrid operating room with the use of intraoperative magnetic resonance tomography, such an approach becomes not merely a recommendation but rather forced and justified necessity. Simultaneous use of various technologies of imaging and treatment with the engagement of physicians of various specialties requires especially thorough control. A generally accepted international standard of the work of the operating block is the use of checklists, and since 2008 the initiative of the World Health Organization "Safe Surgery Saves Lives" has globally been working to promote implementation of the WHO Surgical Safety Checklists (SSCL) to the real clinical practice. The intraoperative MR-diagnostic stage dictates rigid requirements for proper inventory of ferromagnetic and nonmagnetic surgical tools, verified logistics, and routing of the patient in the conditions of high and extremely high (1.5-3.0 T) magnetic field. A separate and not less important problem is anaesthesiological support during MRT. In order to optimise the patient's movements and adequate monitoring of his/her safety inside the operating department, the authors have modified the standard WHO Surgical Safety Checklist. Implementation of the modified checklist for the MRT-equipped hybrid operating room should improve the control over the processes, as well as increase safety of both the patient and personnel. FAU - Cherkashin, M A AU - Cherkashin MA AD - Therapeutic and Diagnostic Centre of the International Institute for Biological Systems named after S.M. Berezin, Saint Petersburg, Russia. FAU - Berezina, N A AU - Berezina NA AD - Therapeutic and Diagnostic Centre of the International Institute for Biological Systems named after S.M. Berezin, Saint Petersburg, Russia. FAU - Kuplevatsky, V I AU - Kuplevatsky VI AD - Therapeutic and Diagnostic Centre of the International Institute for Biological Systems named after S.M. Berezin, Saint Petersburg, Russia. FAU - Serov, A V AU - Serov AV AD - Therapeutic and Diagnostic Centre of the International Institute for Biological Systems named after S.M. Berezin, Saint Petersburg, Russia. FAU - Mefodovsky, A A AU - Mefodovsky AA AD - Therapeutic and Diagnostic Centre of the International Institute for Biological Systems named after S.M. Berezin, Saint Petersburg, Russia. LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Angiol Sosud Khir JT - Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery JID - 9604504 SB - IM MH - Checklist/*standards MH - Humans MH - *Magnetic Resonance Imaging/adverse effects/instrumentation/methods MH - Monitoring, Intraoperative/methods MH - Operating Rooms/*organization & administration MH - Patient Safety/*standards MH - Quality Improvement MH - *Safety Management/methods/standards MH - Surgical Procedures, Operative/methods EDAT- 2016/06/24 06:00 MHDA- 2016/08/25 06:00 CRDT- 2016/06/24 06:00 PHST- 2016/06/24 06:00 [entrez] PHST- 2016/06/24 06:00 [pubmed] PHST- 2016/08/25 06:00 [medline] PST - ppublish SO - Angiol Sosud Khir. 2016;22(2):54-9. PMID- 38547575 OWN - NLM STAT- MEDLINE DCOM- 20240415 LR - 20240415 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 200 DP - 2024 Jun TI - Assessing the collision risk of mixed lane-changing traffic in the urban inter-tunnel weaving section using extreme value theory. PG - 107558 LID - S0001-4575(24)00103-9 [pii] LID - 10.1016/j.aap.2024.107558 [doi] AB - Urban inter-tunnel weaving (UIW) sections are characterized by short lengths and frequent lane-changing behaviors in the area, commonly used for fast through traffic. These features increase the likelihood of collisions, however, collision risk assessment in this area has been inadequate. The aim of this study was to evaluate the potential collision risk of urban inter-tunnel weaving (UIW) sections in mixed lane-changing traffic conditions in morning rush hours, utilizing surrogate safety measures. The investigation involved the collection of trajectory data via an unmanned aerial vehicle (UAV). Time to collision (TTC) and extended time to collision (ETTC) were chosen as surrogate safety indicators. The estimation of collision risk was conducted using Extreme Value Theory (EVT) by means ofsurrogate safety indicators. It was found that the threshold of TTC and ETTC in this area was 1.25 s. Furthermore, a comprehensive evaluation of collision risks associated with various vehicle types was performed, revealing an inverse relationship between thecollisions riskof vehicles in mixed traffic and their size. It was worth noting that while heavy vehicles exhibit a lower collision risk, they resulted in the highest energy loss and inflicted greater harm in the event of a collision. By an examination of the distribution features pertaining to conflict types during the operation of heavy vehicles, it showed that the highest likelihood of conflict with heavy vehicles occurred when adjacent lanes are involved. Consequently, the implementation of assisted driving technology for heavy vehicles was imperative in order to mitigate the risk associated with side collisions. CI - Copyright © 2024 Elsevier Ltd. All rights reserved. FAU - Hu, Xiaojian AU - Hu X AD - Jiangsu Key Laboratory of Urban ITS, Southeast University, Nanjing 211189, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, Southeast University, Nanjing 211189, China; School of Transportation, Southeast University, Nanjing 211189, China. Electronic address: huxiaojian@seu.edu.cn. FAU - Zhou, Jiayi AU - Zhou J AD - Jiangsu Key Laboratory of Urban ITS, Southeast University, Nanjing 211189, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, Southeast University, Nanjing 211189, China; School of Transportation, Southeast University, Nanjing 211189, China. Electronic address: 220235115@seu.edu.cn. FAU - Yang, Yan AU - Yang Y AD - Jiangsu Shidu Information Technology Co., Ltd, China. FAU - Chen, Qian AU - Chen Q AD - Jiangsu Key Laboratory of Urban ITS, Southeast University, Nanjing 211189, China; Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies, Southeast University, Nanjing 211189, China; School of Transportation, Southeast University, Nanjing 211189, China. Electronic address: chenqian_tr@seu.edu.cn. FAU - Zhang, Li AU - Zhang L AD - Huashe Design Group Co. Intelligent City Institute, China. LA - eng PT - Journal Article DEP - 20240327 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Humans MH - *Accidents, Traffic/prevention & control MH - *Automobile Driving MH - Risk Assessment MH - Probability MH - Fatigue OTO - NOTNLM OT - Extreme value theory OT - Mixed lane-changing traffic OT - Surrogate safety measures OT - Urban inter-tunnel weaving section COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/29 00:45 MHDA- 2024/04/15 06:43 CRDT- 2024/03/28 19:03 PHST- 2023/09/25 00:00 [received] PHST- 2024/03/15 00:00 [revised] PHST- 2024/03/21 00:00 [accepted] PHST- 2024/04/15 06:43 [medline] PHST- 2024/03/29 00:45 [pubmed] PHST- 2024/03/28 19:03 [entrez] AID - S0001-4575(24)00103-9 [pii] AID - 10.1016/j.aap.2024.107558 [doi] PST - ppublish SO - Accid Anal Prev. 2024 Jun;200:107558. doi: 10.1016/j.aap.2024.107558. Epub 2024 Mar 27. PMID- 14559420 OWN - NLM STAT- MEDLINE DCOM- 20040302 LR - 20081121 IS - 0003-6870 (Print) IS - 0003-6870 (Linking) VI - 34 IP - 6 DP - 2003 Nov TI - Driving performance in cold, warm, and thermoneutral environments. PG - 597-602 AB - Driving performance deteriorates at high ambient temperatures. Less is known about the effect of low ambient temperatures and the role of subjective aspects like thermal comfort and having control over the ambient temperature. Therefore, an experiment was constructed in which 50 subjects performed a road-tracking task in a cold (5 degrees C), a thermoneutral (20 degrees C) or a warm (35 degrees C) climate. All subjects had a heater/blower (H/B) which generated a fixed amount of heat/wind that could either be controlled or not controlled. In the cold climate, averaged leg skin temperature dropped to 18.5 degrees C and head skin temperature to 24.9 degrees C; the thermal comfort was rated between 'cold' and 'very cold'. In the warm climate, averaged leg skin temperature rose to 36.6 degrees C and head skin temperature to 30.8 degrees C; the thermal comfort was rated as 'hot'. Driving performance in the ambient temperature extremes decreased 16% in the cold environment and 13% in the warm situation. Having control over the local head temperature by adjusting a H/B affected neither thermal comfort nor driving performance. In agreement with the literature on priming effects, subjects who started with the no-control condition performed much better in all driving tasks because they were primed to focus on the driving task as such, rather than the complex combination of temperature controls and driving task. It can be concluded that a thermoneutral temperature in a car enhances driving performance and may thus positively affect safety. Using manual climatic controls in hot or cold cars may interfere with the driving task. FAU - Daanen, Hein A M AU - Daanen HA AD - Department of Work Environment, Thermal Physiology group, TNO Human Factors, P.O. Box 23 Soesterberg, The Netherlands. daanen@tm.tno.nl FAU - van de Vliert, Evert AU - van de Vliert E FAU - Huang, Xu AU - Huang X LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Appl Ergon JT - Applied ergonomics JID - 0261412 SB - IM MH - Adult MH - Analysis of Variance MH - *Automobile Driving MH - *Cold Temperature MH - *Environment, Controlled MH - Female MH - *Hot Temperature MH - Humans MH - Male MH - *Task Performance and Analysis EDAT- 2003/10/16 05:00 MHDA- 2004/03/03 05:00 CRDT- 2003/10/16 05:00 PHST- 2003/10/16 05:00 [pubmed] PHST- 2004/03/03 05:00 [medline] PHST- 2003/10/16 05:00 [entrez] AID - S0003-6870(03)00055-3 [pii] AID - 10.1016/S0003-6870(03)00055-3 [doi] PST - ppublish SO - Appl Ergon. 2003 Nov;34(6):597-602. doi: 10.1016/S0003-6870(03)00055-3. PMID- 39483627 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241102 IS - 2050-3121 (Print) IS - 2050-3121 (Electronic) IS - 2050-3121 (Linking) VI - 12 DP - 2024 TI - Impact of blood pressure variability on hemorrhagic transformation post-rt-PA thrombolysis in patients with acute ischemic stroke. PG - 20503121241283881 LID - 10.1177/20503121241283881 [doi] LID - 20503121241283881 AB - BACKGROUND: The relationship between blood pressure variability and hemorrhagic transformation after recombinant tissue plasminogen activator thrombolysis in patients with acute ischemic stroke is uncertain due to inconsistent methodologies across studies. This study aimed to elucidate the association between 24-h systolic blood pressure extremes post-admission and hemorrhagic transformation while considering the possibility of hemorrhagic transformation occurring beyond the initial monitoring period. METHODS: We enrolled patients admitted to The First Affiliated Hospital of Harbin Medical University for ischemic stroke who were treated with intravenous recombinant tissue plasminogen activator within 4.5 h of symptom onset between January 2020 and December 2022. We analyzed the relationships among admission blood pressure, 24-h post-admission recombinant tissue plasminogen activator (mean, maximum, minimum, extreme difference, standard deviation, and coefficient of variation), immediate and 1-h post-thrombolysis blood pressure, and hemorrhagic transformation occurrence within 36 h post-thrombolysis. The potential for delayed hemorrhagic transformation was also considered during the interpretation of the results. RESULTS: Among the 138 patients, 39.1% experienced post-thrombolytic hemorrhagic transformation. Multivariate analysis revealed that hemorrhagic transformation was significantly associated with coronary artery disease, cerebral leukoaraiosis, large cerebral infarction, elevated random glucose levels, and 24-h systolic blood pressure extremes at admission. Specifically, 24-h systolic blood pressure extremes showed a significant positive correlation with hemorrhagic transformation (OR = 1. 042; 95% CI: 1.000-1.086, p < 0.05). CONCLUSION: These findings underscore the importance of establishing robust protocols for continuous blood pressure monitoring and intervention strategies tailored to individual risk profiles. Given that hemorrhagic transformation can occur beyond the initial 36 h, clinicians should maintain vigilance for delayed hemorrhagic transformation, particularly in patients with high recombinant tissue plasminogen activator. Strict control of blood pressure, especially minimizing extremes in systolic blood pressure, is essential to ensure the safety of patients undergoing thrombolysis. CI - © The Author(s) 2024. FAU - Liu, Sihan AU - Liu S AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Gao, Jiadi AU - Gao J AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhao, Hanshu AU - Zhao H AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Xu, Yuanqi AU - Xu Y AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhou, Yubing AU - Zhou Y AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Liu, Yushuang AU - Liu Y AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Shen, Jinru AU - Shen J AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhang, Zhongling AU - Zhang Z AUID- ORCID: 0000-0003-3646-6761 AD - Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. LA - eng PT - Journal Article DEP - 20240929 PL - England TA - SAGE Open Med JT - SAGE open medicine JID - 101624744 PMC - PMC11526278 OTO - NOTNLM OT - Acute ischemic stroke OT - blood pressure variability OT - hemorrhagic transformation OT - rt-PA OT - thrombolysis COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/11/04 07:23 MHDA- 2024/11/04 07:24 PMCR- 2024/09/29 CRDT- 2024/11/01 05:01 PHST- 2024/06/04 00:00 [received] PHST- 2024/08/29 00:00 [accepted] PHST- 2024/11/04 07:24 [medline] PHST- 2024/11/04 07:23 [pubmed] PHST- 2024/11/01 05:01 [entrez] PHST- 2024/09/29 00:00 [pmc-release] AID - 10.1177_20503121241283881 [pii] AID - 10.1177/20503121241283881 [doi] PST - epublish SO - SAGE Open Med. 2024 Sep 29;12:20503121241283881. doi: 10.1177/20503121241283881. eCollection 2024. PMID- 32885779 OWN - NLM STAT- MEDLINE DCOM- 20201224 LR - 20220915 IS - 1560-7917 (Electronic) IS - 1025-496X (Print) IS - 1025-496X (Linking) VI - 25 IP - 35 DP - 2020 Sep TI - Large waterborne Campylobacter outbreak: use of multiple approaches to investigate contamination of the drinking water supply system, Norway, June 2019. LID - 10.2807/1560-7917.ES.2020.25.35.2000011 [doi] LID - 2000011 AB - On 6 June 2019, the Norwegian Institute of Public Health was notified of more than 50 cases of gastroenteritis in Askøy. A reservoir in a water supply system was suspected as the source of the outbreak because of the acute onset and geographical distribution of cases. We investigated the outbreak to confirm the source, extent of the outbreak and effect of control measures. A case was defined as a person in a household served by Water Supply System A (WSS-A) who had gastroenteritis for more than 24 h between 1 and 19 June 2019. We conducted pilot interviews, a telephone survey and an SMS-based cohort study of residents served by WSS-A. System information of WSS-A was collected. Whole genome sequencing on human and environmental isolates was performed. Among 6,108 individuals, 1,573 fulfilled the case definition. Residents served by the reservoir had a 4.6× higher risk of illness than others. Campylobacter jejuni isolated from cases (n = 24) and water samples (n = 4) had identical core genome MLST profiles. Contamination through cracks in the reservoir most probably occurred during heavy rainfall. Water supply systems are susceptible to contamination, particularly to certain weather conditions. This highlights the importance of water safety planning and risk-based surveillance to mitigate risks. FAU - Hyllestad, Susanne AU - Hyllestad S AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. AD - University of Oslo, Faculty of Medicine, Institute of Health and Society, Oslo, Norway. FAU - Iversen, Arild AU - Iversen A AD - Municipality of Askøy, Norway. FAU - MacDonald, Emily AU - MacDonald E AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Amato, Ettore AU - Amato E AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. AD - European Programme for Public Health Microbiology Training (EUPHEM), European Centre for Disease Control and Prevention (ECDC), Stockholm, Sweden. FAU - Borge, Bengt Åge Sørby AU - Borge BÅS AD - Municipality of Askøy, Norway. FAU - Bøe, Anton AU - Bøe A AD - Municipality of Askøy, Norway. FAU - Sandvin, Aslaug AU - Sandvin A AD - Norwegian Food Safety Authority, Bergen, Norway. FAU - Brandal, Lin T AU - Brandal LT AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Lyngstad, Trude Marie AU - Lyngstad TM AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Naseer, Umaer AU - Naseer U AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Nygård, Karin AU - Nygård K AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Veneti, Lamprini AU - Veneti L AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Vold, Line AU - Vold L AD - Department of Zoonoses, Food- and Waterborne Diseases, Norwegian Institute of Public Health, Oslo, Norway. LA - eng PT - Journal Article PL - Sweden TA - Euro Surveill JT - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JID - 100887452 RN - 0 (Drinking Water) SB - IM EIN - Euro Surveill. 2020 Oct;25(43). doi: 10.2807/1560-7917.ES.2020.25.43.201029c2. PMID: 33124549 MH - Abdominal Pain/etiology MH - Campylobacter Infections/diagnosis/*epidemiology MH - Campylobacter jejuni/genetics/*isolation & purification MH - Child MH - Child, Preschool MH - Cohort Studies MH - Diarrhea/etiology MH - Disease Outbreaks/*statistics & numerical data MH - Drinking Water/*microbiology MH - Female MH - Gastroenteritis/epidemiology MH - Headache/etiology MH - Humans MH - Incidence MH - Male MH - Multilocus Sequence Typing MH - Norway/epidemiology MH - Retrospective Studies MH - Surveys and Questionnaires MH - *Water Supply MH - Whole Genome Sequencing PMC - PMC7472686 OTO - NOTNLM OT - Campylobacter OT - Norway OT - climate OT - disease outbreaks OT - drinking OT - extreme weather OT - gastroenteritis OT - water supply COIS- Conflict of interest: None declared. EDAT- 2020/09/05 06:00 MHDA- 2020/12/29 06:00 PMCR- 2020/09/03 CRDT- 2020/09/05 06:00 PHST- 2020/09/05 06:00 [entrez] PHST- 2020/09/05 06:00 [pubmed] PHST- 2020/12/29 06:00 [medline] PHST- 2020/09/03 00:00 [pmc-release] AID - 2000011 [pii] AID - 10.2807/1560-7917.ES.2020.25.35.2000011 [doi] PST - ppublish SO - Euro Surveill. 2020 Sep;25(35):2000011. doi: 10.2807/1560-7917.ES.2020.25.35.2000011. PMID- 28946631 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2072-6694 (Print) IS - 2072-6694 (Electronic) IS - 2072-6694 (Linking) VI - 9 IP - 10 DP - 2017 Sep 23 TI - Alcohol Misuse Link to POEMS Syndrome in a Patient. LID - 10.3390/cancers9100129 [doi] LID - 129 AB - Previously called Crow-Fukase syndrome, POEMS syndrome is characterized by poly-neuropathy, osteo-sclerotic myeloma, organomegaly, endocrinopathy, monoclonal plasma cell disorder, and skin changes. Extremely elevated levels of serum vascular endothelial growth factor (VEGF) are characteristic of the syndrome. Chronic hepatitis B (HBV) and C (HCV) infections can also be present in POEMS. The pathogenesis of the syndrome is not well understood. The link between chronic alcohol consumption and this malignant condition has not been reported until now. In addition, no previous study has evaluated the influence of cytokine and chemokines or viruses in the severity and evolution of POEMS. OBJECTIVES: (1) to describe a heavy-alcohol user, who was diagnosed with POEMS; (2) to demonstrate the utility of quantitative measurement of serum levels of VEGF in the diagnosis of POEMS and the monitoring of therapeutic interventions; (3) to demonstrate that overproduction of pro-inflammatory cytokines is a characteristic of POEMS. METHODS: We describe a case of a POEMS patient presenting HCV and who is a heavy drinker; we compare the serum levels of cytokines and chemokines between the POEMS patient with 80 patients with HCV, 12 healthy controls, and 80 individuals with alcoholic liver disease (ALD). We quantified (ELISA pg/mL) the levels of VEGF, Interferon gamma (IFN-γ), Tumor Necrosis Factor alpha (TNF-α), Regulated-upon-Activation Normal-T-cell-Expressed and presumably-Secreted (RANTES), and Nuclear Factor kappa-B (NFκB). RESULTS: In POEMS patients, VEGF levels were elevated versus control or other diseases, TNFα levels were higher versus control, but lower when compared with HCV or ALD patients. VEGF levels in POEMS patients decreased with therapeutic intervention. CONCLUSIONS: Chronic alcohol misuse can be a strong risk factor to rare malignancies such as POEMS syndrome. Extreme elevation of VEGF levels is diagnostic for POEMS syndrome, and should be followed to assess response to therapy. In addition, other comorbidities should be considered individually to ensure personalized therapeutic intervention. FAU - Neary, John AU - Neary J AD - Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada. john.neary@medportal.ca. FAU - Goodwin, Susan E AU - Goodwin SE AD - Juravinski Hospital, Hamilton, ON L8N 3Z5, Canada. fawcetts@mcmaster.ca. FAU - Cohen, Lawrence B AU - Cohen LB AD - Division of Gastroenterology, Sunnybrook Health Sciences Centre and Department of Internal Medicine, University of Toronto, Toronto, ON M4N 3M5, Canada. lawrence.cohen@sunnybrook.ca. FAU - Neuman, Manuela G AU - Neuman MG AD - In Vitro Drug Safety and Biotechnology, Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5G 1L5, Canada. manuela.neuman@utoronto.ca. LA - eng PT - Case Reports PT - Journal Article DEP - 20170923 PL - Switzerland TA - Cancers (Basel) JT - Cancers JID - 101526829 PMC - PMC5664068 OTO - NOTNLM OT - POEMS OT - RANTES OT - TNF-alpha OT - VEGF OT - alcohol OT - biomarkers OT - malignancy COIS- The authors declare no conflict of interest. J. Neary and S.E. Goodwin are the treating physicians of the patient, L.B. Cohen clinically diagnosed and treated the patients from the control groups and M.G. Neuman designed the study and performed all the laboratory analyses of the entire study. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results. EDAT- 2017/09/28 06:00 MHDA- 2017/09/28 06:01 PMCR- 2017/09/23 CRDT- 2017/09/27 06:00 PHST- 2017/09/04 00:00 [received] PHST- 2017/09/15 00:00 [revised] PHST- 2017/09/19 00:00 [accepted] PHST- 2017/09/27 06:00 [entrez] PHST- 2017/09/28 06:00 [pubmed] PHST- 2017/09/28 06:01 [medline] PHST- 2017/09/23 00:00 [pmc-release] AID - cancers9100129 [pii] AID - cancers-09-00129 [pii] AID - 10.3390/cancers9100129 [doi] PST - epublish SO - Cancers (Basel). 2017 Sep 23;9(10):129. doi: 10.3390/cancers9100129. PMID- 12134472 OWN - NLM STAT- MEDLINE DCOM- 20030110 LR - 20191106 IS - 0272-2712 (Print) IS - 0272-2712 (Linking) VI - 22 IP - 2 DP - 2002 Jun TI - Advances in pretransfusion infectious disease testing: ensuring the safety of transfusion therapy. PG - 475-90 AB - The public expects a zero-tolerance policy for the transmission of infectious agents by blood transfusion. Although unrealistic, the efforts to reach this goal have produced an extremely safe albeit costly blood supply [82]. Blood collecting agencies, the FDA, physicians, and scientists have over the past 20 years created a complex system of layers of protection to interdict transfusion-transmitted infections (Fig. 2). As new, exotic, potentially blood transmittable infectious agents evolve [83], new barriers will be erected to [figure: see text] interdict these agents. In the interim, the US blood supply is the safest in the world. FAU - Downes, Katharine A AU - Downes KA AD - American Red Cross Citywide Program, Department of Pathology, Case Western Reserve University, Blood Bank, University Hospitals of Cleveland, Cleveland, OH, USA. FAU - Yomtovian, Roslyn AU - Yomtovian R LA - eng PT - Journal Article PT - Review PL - United States TA - Clin Lab Med JT - Clinics in laboratory medicine JID - 8100174 SB - IM MH - Blood Banks/*standards MH - Blood Donors MH - *Blood Transfusion/standards MH - Blood-Borne Pathogens MH - Communicable Disease Control/*methods/standards MH - Communicable Diseases, Emerging/transmission MH - Humans MH - Pathology, Clinical/*methods MH - Safety MH - Transfusion Reaction RF - 83 EDAT- 2002/07/24 10:00 MHDA- 2003/01/11 04:00 CRDT- 2002/07/24 10:00 PHST- 2002/07/24 10:00 [pubmed] PHST- 2003/01/11 04:00 [medline] PHST- 2002/07/24 10:00 [entrez] AID - S0272-2712(01)00007-5 [pii] AID - 10.1016/s0272-2712(01)00007-5 [doi] PST - ppublish SO - Clin Lab Med. 2002 Jun;22(2):475-90. doi: 10.1016/s0272-2712(01)00007-5. PMID- 22977542 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211021 IS - 1792-0981 (Print) IS - 1792-1015 (Electronic) IS - 1792-0981 (Linking) VI - 2 IP - 3 DP - 2011 May TI - Pulmonary alveolar proteinosis and successful therapy with combined lavage procedures: Case reports. PG - 569-573 AB - Pulmonary alveolar proteinosis (PAP) is a rare disease characterized by the accumulation of lipoproteinaceous material within alveolar spaces. Whole-lung lavage (WLL) has been the most common therapeutic intervention for this disorder. However, patients presenting with PAP are usually hypoxemic or in poor clinical condition, and WLL may be impossible to perform. In such cases, multiple segmental lavage (MSL) may be advocated as a first-choice therapy prior to WLL. Herein, we present two cases with idiopathic PAP treated successfully with both lavage techniques consecutively. After the MSL procedure, WLL was performed, and both patients showed a marked clinical and physiologic improvement. Therefore, for patients who are not good candidates for general anesthesia, we recommend MSL (or 'prewash') before WLL to produce an increase in the blood oxygen level for long-duration general anesthesia. In the surgical room, close monitoring and repositioning of the patient as well as maintenance and inspection of the correct tube position, and manual chest wall percussion are extremely important for the safety and success of the procedure. FAU - Firat, Nalan Demır AU - Firat ND AD - Departments of Chest Diseases. FAU - Cıledağ, Aydin AU - Cıledağ A FAU - Kabalak, Pinar Akin AU - Kabalak PA FAU - Karnak, Demet AU - Karnak D FAU - Meco, Başak Ceyda AU - Meco BC FAU - Alanoğlu, Zekerıyya AU - Alanoğlu Z FAU - Alkiş, Neslıhan AU - Alkiş N LA - eng PT - Journal Article DEP - 20110318 PL - Greece TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC3440708 EDAT- 2011/05/01 00:00 MHDA- 2011/05/01 00:01 PMCR- 2011/03/18 CRDT- 2012/09/15 06:00 PHST- 2011/02/02 00:00 [received] PHST- 2011/03/16 00:00 [accepted] PHST- 2012/09/15 06:00 [entrez] PHST- 2011/05/01 00:00 [pubmed] PHST- 2011/05/01 00:01 [medline] PHST- 2011/03/18 00:00 [pmc-release] AID - etm-02-03-0569 [pii] AID - 10.3892/etm.2011.230 [doi] PST - ppublish SO - Exp Ther Med. 2011 May;2(3):569-573. doi: 10.3892/etm.2011.230. Epub 2011 Mar 18. PMID- 30836293 OWN - NLM STAT- MEDLINE DCOM- 20190502 LR - 20190502 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 127 DP - 2019 Jun TI - A new integrated collision risk assessment methodology for autonomous vehicles. PG - 61-79 LID - S0001-4575(18)30661-4 [pii] LID - 10.1016/j.aap.2019.01.029 [doi] AB - Real-time risk assessment of autonomous driving at tactical and operational levels is extremely challenging since both contextual and circumferential factors should concurrently be considered. Recent methods have started to simultaneously treat the context of the traffic environment along with vehicle dynamics. In particular, interaction-aware motion models that take inter-vehicle dependencies into account by utilizing the Bayesian interference are employed to mutually control multiple factors. However, communications between vehicles are often assumed and the developed models are required many parameters to be tuned. Consequently, they are computationally very demanding. Even in the cases where these desiderata are fulfilled, current approaches cannot cope with a large volume of sequential data from organically changing traffic scenarios, especially in highly complex operational environments such as dense urban areas with heterogeneous road users. To overcome these limitations, this paper develops a new risk assessment methodology that integrates a network-level collision estimate with a vehicle-based risk estimate in real-time under the joint framework of interaction-aware motion models and Dynamic Bayesian Networks (DBN). Following the formulation and explanation of the required functions, machine learning classifiers were utilized for the real-time network-level collision prediction and the results were then incorporated into the integrated DBN model for predicting collision probabilities in real-time. Results indicated an enhancement of the interaction-aware model by up to 10%, when traffic conditions are deemed as collision-prone. Hence, it was concluded that a well-calibrated collision prediction classifier provides a crucial hint for better risk perception by autonomous vehicles. CI - Copyright © 2019 Elsevier Ltd. All rights reserved. FAU - Katrakazas, Christos AU - Katrakazas C AD - Chair of Transportation Systems Engineering, Department of Civil, Geo and Environmental Engineering, Technical University of Munich, Arcistrasse 21, Munich, 80333, Germany. Electronic address: c.katrakazas@tum.de. FAU - Quddus, Mohammed AU - Quddus M AD - School of Architecture, Building and Civil Engineering, Loughborough University, Loughborough, LE11 3TU, United Kingdom. Electronic address: m.a.quddus@lboro.ac.uk. FAU - Chen, Wen-Hua AU - Chen WH AD - Department of Aeronautical and Automotive Engineering Loughborough University Loughborough, LE11 3TU, United Kingdom. Electronic address: w.chen@lboro.ac.uk. LA - eng PT - Journal Article DEP - 20190302 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*prevention & control MH - Artificial Intelligence MH - *Automobile Driving MH - Bayes Theorem MH - Calibration MH - Humans MH - Risk Assessment MH - Safety EDAT- 2019/03/06 06:00 MHDA- 2019/05/03 06:00 CRDT- 2019/03/06 06:00 PHST- 2018/09/20 00:00 [received] PHST- 2019/01/24 00:00 [revised] PHST- 2019/01/24 00:00 [accepted] PHST- 2019/03/06 06:00 [pubmed] PHST- 2019/05/03 06:00 [medline] PHST- 2019/03/06 06:00 [entrez] AID - S0001-4575(18)30661-4 [pii] AID - 10.1016/j.aap.2019.01.029 [doi] PST - ppublish SO - Accid Anal Prev. 2019 Jun;127:61-79. doi: 10.1016/j.aap.2019.01.029. Epub 2019 Mar 2. PMID- 31656556 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2041-2851 (Print) IS - 2041-2851 (Electronic) VI - 11 IP - 5 DP - 2019 Oct TI - Six co-occurring conifer species in northern Idaho exhibit a continuum of hydraulic strategies during an extreme drought year. PG - plz056 LID - 10.1093/aobpla/plz056 [doi] LID - plz056 AB - As growing seasons in the northwestern USA lengthen, on track with climate predictions, the mixed conifer forests that dominate this region will experience extended seasonal drought conditions. The year of 2015, which had the most extreme drought for the area on record, offered a potential analogue of future conditions. During this period, we measured the daily courses of water potential and gas exchange as well as the hydraulic conductivity and vulnerability to embolism of six dominant native conifer species, Abies grandis, Larix occidentalis, Pinus ponderosa, Pinus monticola, Pseudotsuga menziesii and Thuja occidentalis, to determine their responses to 5 months of record-low precipitation. The deep ash-capped soils of the region allowed gas exchange to continue without significant evidence of water stress for almost 2 months after the last rainfall event. Midday water potentials never fell below -2.2 MPa in the evergreen species and -2.7 MPa in the one deciduous species. Branch xylem was resistant to embolism, with P (50) values ranging from -3.3 to -7.0 MPa. Root xylem, however, was more vulnerable, with P (50) values from -1.3 to -4.6 MPa. With predawn water potentials as low as -1.3 MPa, the two Pinus species likely experienced declines in root hydraulic conductivity. Stomatal conductance of all six species was significantly responsive to vapour pressure only in the dry months (August-October), with no response evident in the wet months (June-July). While there were similarities among species, they exhibited a continuum of isohydry and safety margins. Despite the severity of this drought, all species were able to continue photosynthesis until mid-October, likely due to the mediating effects of the meter-deep, ash-capped silty-loam soils with large water storage capacity. Areas with these soil types, which are characteristic of much of the northwestern USA, could serve as refugia under drier and warmer future conditions. CI - © The Author(s) 2019. Published by Oxford University Press on behalf of the Annals of Botany Company. FAU - Baker, Kathryn V AU - Baker KV AD - Department of Forest, Rangeland and Fire Sciences, University of Idaho, Moscow, ID, USA. AD - Department of Environmental Science, Marist College, Poughkeepsie, NY, USA. FAU - Tai, Xiaonan AU - Tai X AD - Department of Geology and Geophysics, University of Utah, Salt Lake City, UT, USA. FAU - Miller, Megan L AU - Miller ML AD - Department of Forest, Rangeland and Fire Sciences, University of Idaho, Moscow, ID, USA. FAU - Johnson, Daniel M AU - Johnson DM AD - Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA. LA - eng PT - Journal Article DEP - 20190923 PL - England TA - AoB Plants JT - AoB PLANTS JID - 101539425 PMC - PMC6804486 OTO - NOTNLM OT - Hydraulic conductivity OT - P50 OT - Pinaceae OT - safety margin OT - stomatal conductance OT - water potential EDAT- 2019/10/28 06:00 MHDA- 2019/10/28 06:01 PMCR- 2019/09/23 CRDT- 2019/10/29 06:00 PHST- 2019/01/25 00:00 [received] PHST- 2019/09/02 00:00 [accepted] PHST- 2019/10/29 06:00 [entrez] PHST- 2019/10/28 06:00 [pubmed] PHST- 2019/10/28 06:01 [medline] PHST- 2019/09/23 00:00 [pmc-release] AID - plz056 [pii] AID - 10.1093/aobpla/plz056 [doi] PST - epublish SO - AoB Plants. 2019 Sep 23;11(5):plz056. doi: 10.1093/aobpla/plz056. eCollection 2019 Oct. PMID- 18322675 OWN - NLM STAT- MEDLINE DCOM- 20080801 LR - 20090304 IS - 0340-5761 (Print) IS - 0340-5761 (Linking) VI - 82 IP - 4 DP - 2008 Apr TI - Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European Chemicals Legislation (REACH). PG - 211-36 LID - 10.1007/s00204-008-0279-9 [doi] AB - During the last two decades, substantial efforts have been made towards the development and international acceptance of alternative methods to safety studies using laboratory animals. In the EU, challenging timelines for phasing out of many standard tests using laboratory animals were established in the seventh Amending Directive 2003/15/EC to Cosmetics Directive 76/768/EEC. In continuation of this policy, the new European Chemicals Legislation (REACH) favours alternative methods to conventional in vivo testing, if validated and appropriate. Even alternative methods in the status of prevalidation or validation, but without scientific or regulatory acceptance may be used under certain conditions. Considerable progress in the establishment of alternative methods has been made in some fields, in particular with respect to methods predicting local toxic effects and genotoxicity. In more complex important fields of safety and risk assessment such as systemic single and repeated dose toxicity, toxicokinetics, sensitisation, reproductive toxicity and carcinogenicity, it is expected that the development and validation of in silico methods, testing batteries (in vitro and in silico) and tiered testing systems will have to overcome many scientific and regulatory obstacles which makes it extremely difficult to predict the outcome and the time needed. The main reasons are the complexity and limited knowledge of the biological processes involved on one hand and the long time frame until validation and regulatory acceptance of an alternative method on the other. New approaches in safety testing and evaluation using "Integrated Testing Strategies" (ITS) (including combinations of existing data, the use of chemical categories/grouping, in vitro tests and QSAR) that have not been validated or not gained wide acceptance in the scientific community and by regulatory authorities will need a thorough justification of their appropriateness for a given purpose. This requires the availability of knowledge and experience of experts in toxicology. The challenging deadlines for phasing out of in vivo tests in the Cosmetics Amending Directive 2003/15/EC appear unrealistic. Likewise, we expect that the application of validated alternative methods will only have a small or moderate impact on the reduction of in vivo tests under the regimen of REACH, provided that at least the same level of protection of human health as in the past is envisaged. As a consequence, under safety aspects, it appears wise to consider established in vivo tests to be indispensable as basic tools for hazard and risk assessment with respect to systemic single and repeated dose toxicity, sensitisation, carcinogenicity and reproductive toxicity, especially regarding quantitative aspects of risk assessment such as NOAELs, LOAELs and health-related limit values derived from them. Based on the overall evaluation in this review, the authors are of the opinion that in the short- and mid-term, the strategy of the development of alternative methods should be more directed towards the refinement or reduction of in vivo tests. The lessons learnt during these efforts will provide a substantial contribution towards the replacement initiatives in the long-term. FAU - Lilienblum, W AU - Lilienblum W AD - Dr Lilienblum Consulting Toxicology LiCoTox, Hemmingen/Han, Germany. werner.lilienblum@t-online.de FAU - Dekant, W AU - Dekant W FAU - Foth, H AU - Foth H FAU - Gebel, T AU - Gebel T FAU - Hengstler, J G AU - Hengstler JG FAU - Kahl, R AU - Kahl R FAU - Kramer, P-J AU - Kramer PJ FAU - Schweinfurth, H AU - Schweinfurth H FAU - Wollin, K-M AU - Wollin KM LA - eng PT - Journal Article DEP - 20080306 PL - Germany TA - Arch Toxicol JT - Archives of toxicology JID - 0417615 SB - IM CIN - Arch Toxicol. 2009 Jan;83(1):9-10. doi: 10.1007/s00204-008-0383-x. PMID: 19002668 CIN - Arch Toxicol. 2009 Jan;83(1):5-7. doi: 10.1007/s00204-008-0384-9. PMID: 19034432 MH - Animal Testing Alternatives/*legislation & jurisprudence MH - Animal Welfare/legislation & jurisprudence MH - Animals MH - *Animals, Laboratory MH - Europe MH - Guidelines as Topic MH - Humans MH - Risk Assessment MH - *Safety/legislation & jurisprudence MH - *Toxicity Tests/methods EDAT- 2008/03/07 09:00 MHDA- 2008/08/02 09:00 CRDT- 2008/03/07 09:00 PHST- 2007/12/14 00:00 [received] PHST- 2008/01/07 00:00 [accepted] PHST- 2008/03/07 09:00 [pubmed] PHST- 2008/08/02 09:00 [medline] PHST- 2008/03/07 09:00 [entrez] AID - 10.1007/s00204-008-0279-9 [doi] PST - ppublish SO - Arch Toxicol. 2008 Apr;82(4):211-36. doi: 10.1007/s00204-008-0279-9. Epub 2008 Mar 6. PMID- 37564015 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231020 IS - 2051-6355 (Electronic) IS - 2051-6347 (Linking) VI - 10 IP - 10 DP - 2023 Oct 2 TI - A biomimetic closed-loop recyclable, long-term durable, extreme-condition resistant, flame-retardant nanocoating synthesized by reversible flocculation assembly. PG - 4551-4561 LID - 10.1039/d3mh00720k [doi] AB - Flame-retardant coatings have attracted increasing attention in mitigating the fire threat of flammable polymer materials. Their durable application inevitably provides high resistance to various complex environments, however, discarded stable materials will turn into another man-made waste disaster. The paradigm shift toward a sustainable future is to combine durability and recyclability of coatings. Herein, we demonstrate a biomimetic coating that reversibly captures active flame-retardant nanomaterials by flocculation assembly using anionic polyacrylamide covering the polyurethane foam surface. Strong hydrogen bonding and microstructural interlocking provide the coating with high durability under complex harsh conditions (underwater, chemical exposure, hydrothermal aging, long-term external extrusion, etc.). Meanwhile, the disassembly/reorganization of the coating can be easily repeated in response to pH stimulation with a recycling rate of 97%. The experiments and theoretical calculations reveal the mechanism of the reversible flocculation assembly. This biomimetic strategy of responsive flocculation assembly opens the way for functional coatings with integrated durability and recyclability. FAU - Zhang, Jiayan AU - Zhang J AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Zeng, Furong AU - Zeng F AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Liu, Bowen AU - Liu B AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Wang, Zihao AU - Wang Z AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Lin, Xincen AU - Lin X AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Zhao, Haibo AU - Zhao H AUID- ORCID: 0000-0002-5455-2965 AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. FAU - Wang, Yuzhong AU - Wang Y AD - The Collaborative Innovation Center for Eco-Friendly and Fire-safety Polymeric Materials, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Sichuan 610064, China. haibor7@163.com. LA - eng PT - Journal Article DEP - 20231002 PL - England TA - Mater Horiz JT - Materials horizons JID - 101623537 SB - IM EDAT- 2023/08/11 06:42 MHDA- 2023/08/11 06:43 CRDT- 2023/08/11 03:32 PHST- 2023/08/11 06:43 [medline] PHST- 2023/08/11 06:42 [pubmed] PHST- 2023/08/11 03:32 [entrez] AID - 10.1039/d3mh00720k [doi] PST - epublish SO - Mater Horiz. 2023 Oct 2;10(10):4551-4561. doi: 10.1039/d3mh00720k. PMID- 12179873 OWN - PIP STAT- MEDLINE DCOM- 19881107 LR - 20161021 IS - 0731-7220 (Print) IS - 0731-7220 (Linking) VI - 9 IP - 2 DP - 1988 Feb TI - Depo Provera: still controversial. PG - 2-3, 8 FAU - Wren, L M AU - Wren LM LA - eng PT - Journal Article PL - United States TA - Int Health News JT - International health news JID - 9880561 RN - 0 (Contraceptive Agents) RN - 0 (Contraceptive Agents, Female) RN - 0 (Hormones) RN - 0 (Reproductive Control Agents) RN - C2QI4IOI2G (Medroxyprogesterone Acetate) MH - Americas MH - *Animals, Laboratory MH - Biology MH - *Breast Neoplasms MH - Contraception MH - Contraceptive Agents MH - Contraceptive Agents, Female MH - *Developed Countries MH - *Developing Countries MH - *Disease MH - Economics MH - Endocrine System MH - Family Planning Services MH - *Government Agencies MH - *Hormones MH - *Medroxyprogesterone Acetate MH - *Neoplasms MH - North America MH - *Organizations MH - Physiology MH - *Politics MH - *Reproductive Control Agents MH - *Research MH - Technology MH - United States OID - PIP: 047847 OID - POP: 00175723 OAB - The use of depo-medroxyprogesterone acetate (DMPA), or Depo Provera, has been debated for the 20 years since it became available in 1967. The US Food and Drug Administration (FDA) refused to approve Depo Provera on the basis that it caused breast tumors in a controlled study of Beagle dogs and Rhesus monkeys conducted by Upjohn, the manufacturer. Depo Provera has been approved in over 60 other countries and is in use in 30 or 40 others with an estimated total of almost 5 million users. A natural hormone, progesterone, DMPA is injected intramuscularly and absorbed slowly. Common dosage is 150 mg every 3 months and usually is administered during the 1st week of the menstrual cycle. The pregnancy rate with Depo Provera is .44 pregnancies/100 women years for women receiving 100 mg every 3 months. No pregnancies were recorded in recent studies for women receiving 150 mg. Possible side effects include amenorrhea, weight gain, dizziness and headaches. The median time for contraception after the presumed duration of one's last injection is 5-1/2 months. Some countries only permit women who already have 1 child to use Depo Provera. The FDA in the US approves the use of Depo Provera for treatment of endometrial and renal cancer but accuses it of causing cancer in Beagles and Rhesus monkeys. The studies were conducted over 7 and 10-year periods, respectively, with extremely negative results including the death of 3 dogs due to "drug-induced diabetes," atrophication of adrenal glands, and malignant tumors. There were similar results for the monkey study. In the UK, the Committee for Safety in Medicine supports Upjohn's view that Beagles are unsuitable for comparison testing because "all dogs are acutely sensitive to progesterone." Groups such as the National Women's Health Network, the institute for Food and Development Policy, and "Mother Jones" have used the media to generate opposition to Depo Provera, citing a double standard for rich and poor women, developed and less developed countries. The proponents of Depo Provera criticize health activists for imposing their own standards on women in developing countries. Regarding concerns about greater risk of Acquired Immune Deficiency Syndrome (AIDS), Depo Provera can be injected with disposable needles. In response to the controversy, Upjohn withdrew its application to the FDA in September 1986 but intends to resubmit with new information from a World Health Organization report, which showed no evidence of an increased risk of cancers of the endometrium, liver, or breast. OABL- eng OTO - PIP OT - Americas OT - *Animals, Laboratory OT - Biology OT - *Breast Cancer OT - *Cancer OT - *Clinical Research OT - Contraception OT - Contraceptive Agents, Female--side effects OT - Contraceptive Agents, Progestin--side effects OT - Contraceptive Agents--side effects OT - *Depo-provera--side effects OT - *Developed Countries OT - *Developing Countries OT - *Diseases OT - Economic Factors OT - Endocrine System OT - Family Planning OT - *Government Agencies--standards OT - *Hormones OT - *Medroxyprogesterone Acetate--side effects OT - *Neoplasms OT - North America OT - *Northern America OT - *Organizations OT - Physiology OT - *Political Factors OT - *Reproductive Control Agents OT - *Research And Development OT - Research Methodology OT - Technology OT - United States GN - PIP: TJ: INTERNATIONAL HEALTH NEWS EDAT- 1988/02/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1988/02/01 00:00 PHST- 1988/02/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1988/02/01 00:00 [entrez] PST - ppublish SO - Int Health News. 1988 Feb;9(2):2-3, 8. PMID- 25097683 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20140806 LR - 20220410 IS - 1895-4588 (Print) IS - 2299-0054 (Electronic) IS - 1895-4588 (Linking) VI - 9 IP - 2 DP - 2014 Jun TI - Minimally invasive procedures in severe acute pancreatitis treatment - assessment of benefits and possibilities of use. PG - 170-8 LID - 10.5114/wiitm.2014.41628 [doi] AB - INTRODUCTION: Acute pancreatitis (AP) consists of an extremely varied complex of pathological symptoms and clinical conditions, ranging from mild gastric complaints to multi-organ failure resulting in death. AIM: To present the authors' own experience regarding surgical treatment for pancreatic necrosis complicated by infection using different methods, including classic and laparoscopic methods as well as those combined with percutaneous techniques. MATERIAL AND METHODS: In the period 2007-2010, 34 patients with the diagnosis of severe AP were treated at the Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum, Nicolaus Copernicus University. In 7 patients classic necrosectomy with repeated peritoneal flushing was performed (type 1), in 5 patients laparotomy with active drainage (type 2), in 12 video-assisted retroperitoneal debridement (type 3), and in 10 only percutaneous drainage methods (type 4). RESULTS: Total duration of hospitalisation was from 10 to 192 days. The highest death rate was observed for type 1 procedures. Significant differences with regard to the absolute number of postoperative complications between different groups were not observed; however, their quality varied. Classic methods were used in patients whose general and local condition was more severe. CONCLUSIONS: When AP and its complications are diagnosed, a suitable method of surgical treatment has to be selected extremely precisely and in an individualised way. Minimally invasive methods used in selected patients provide better outcomes and higher safety superseding classic, open techniques of surgical treatment. FAU - Szeliga, Jacek AU - Szeliga J AD - Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, Torun, Poland. FAU - Jackowski, Marek AU - Jackowski M AD - Department of General, Gastroenterological and Oncological Surgery, Collegium Medicum Nicolaus Copernicus University, Torun, Poland. LA - eng PT - Journal Article DEP - 20140401 PL - Poland TA - Wideochir Inne Tech Maloinwazyjne JT - Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques JID - 101283175 PMC - PMC4105673 OTO - NOTNLM OT - acute pancreatitis OT - infected pancreatic necrosis OT - video-assisted retroperitoneal debridement EDAT- 2014/08/07 06:00 MHDA- 2014/08/07 06:01 PMCR- 2014/06/01 CRDT- 2014/08/07 06:00 PHST- 2013/07/08 00:00 [received] PHST- 2013/08/24 00:00 [revised] PHST- 2013/10/14 00:00 [accepted] PHST- 2014/08/07 06:00 [entrez] PHST- 2014/08/07 06:00 [pubmed] PHST- 2014/08/07 06:01 [medline] PHST- 2014/06/01 00:00 [pmc-release] AID - 22523 [pii] AID - 10.5114/wiitm.2014.41628 [doi] PST - ppublish SO - Wideochir Inne Tech Maloinwazyjne. 2014 Jun;9(2):170-8. doi: 10.5114/wiitm.2014.41628. Epub 2014 Apr 1. PMID- 28615304 OWN - NLM STAT- MEDLINE DCOM- 20180226 LR - 20180301 IS - 1468-2052 (Electronic) IS - 1359-2998 (Linking) VI - 103 IP - 2 DP - 2018 Mar TI - Ibuprofen exposure in early neonatal life does not affect renal function in young adolescence. PG - F107-F111 LID - 10.1136/archdischild-2017-312922 [doi] AB - INTRODUCTION: Ibuprofen exposure results in acute transient renal dysfunction in preterm neonates, but we are unaware of data on long-term renal safety. METHODS: In a previously studied cohort of extreme low birth weight (ELBW, <1000 g) cases, the PREMATurity as predictor of children's Cardiovascular-renal Health study generated data on renal function (renal length, estimated glomerular filtration rate based on cystatin C (eGFR(cysC)) at the age of 11 years. This data set in 93 ELBW cases may also generate data on long-term drug safety on ibuprofen. In this post hoc analysis, we linked markers of renal function in young adolescence in ELBW cases with their perinatal (prenatal maternal, setting at birth, treatment modalities including drug prescription during neonatal stay, neonatal creatinine values, postdischarge growth) characteristics, including but not limited to ibuprofen exposure during neonatal stay. RESULTS: Ibuprofen exposure was not associated with significant differences in renal length or eGFR(cysC). Moreover, we were unable to identify any other risk factor (perinatal characteristics, postnatal creatinine trends, postdischarge growth) on renal outcome in this cohort. CONCLUSIONS: Neonatal exposure to ibuprofen did not affect renal function. Larger studies are needed to explore the confounders of variability in renal function in former ELBW cases. This matters since ELBW relates to risk for hypertension, cardiovascular events and renal disease in later life and identification of risk factors holds the promise of secondary prevention. TRIAL REGISTRATION NUMBER: NCT02147457. CI - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. FAU - Raaijmakers, Anke AU - Raaijmakers A AD - Department of Pediatrics and Neonatology, University Hospitals Leuven, Leuven, Belgium. AD - KU Leuven Department of Development and Regeneration, University of Leuven, Leuven, Belgium. FAU - Zhang, Zhen-Yu AU - Zhang ZY AD - Department of Pediatrics and Neonatology, University Hospitals Leuven, Leuven, Belgium. AD - KU Leuven Department of Development and Regeneration, University of Leuven, Leuven, Belgium. AD - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. FAU - Levtchenko, Elena AU - Levtchenko E AD - Department of Pediatrics and Neonatology, University Hospitals Leuven, Leuven, Belgium. FAU - Simons, Sinno Hp AU - Simons SH AD - Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands. FAU - Cauwenberghs, Nicholas AU - Cauwenberghs N AD - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. FAU - Heuvel, Lambertus P van den AU - Heuvel LPVD AD - KU Leuven Department of Development and Regeneration, University of Leuven, Leuven, Belgium. FAU - Jacobs, Lotte AU - Jacobs L AD - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. FAU - Staessen, Jan A AU - Staessen JA AD - Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. AD - R&D Group VitaK, Maastricht University, Maastricht, The Netherlands. FAU - Allegaert, Karel AU - Allegaert K AUID- ORCID: 0000-0001-9921-5105 AD - KU Leuven Department of Development and Regeneration, University of Leuven, Leuven, Belgium. AD - Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands. AD - Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center Sophia Children's Hospital, Rotterdam, The Netherlands. LA - eng SI - ClinicalTrials.gov/NCT02147457 PT - Journal Article DEP - 20170614 PL - England TA - Arch Dis Child Fetal Neonatal Ed JT - Archives of disease in childhood. Fetal and neonatal edition JID - 9501297 RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Child MH - Child Development/drug effects MH - Ductus Arteriosus, Patent/drug therapy MH - Female MH - Gestational Age MH - Humans MH - Ibuprofen/*adverse effects/therapeutic use MH - *Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Kidney/growth & development MH - Kidney Function Tests MH - Male MH - Perinatal Care MH - Renal Insufficiency/chemically induced/*epidemiology MH - Risk Factors OTO - NOTNLM OT - Cystatin C OT - drug safety OT - ibuprofen OT - preterm COIS- Competing interests: None declared. EDAT- 2017/06/16 06:00 MHDA- 2018/02/27 06:00 CRDT- 2017/06/16 06:00 PHST- 2017/02/22 00:00 [received] PHST- 2017/04/27 00:00 [revised] PHST- 2017/04/27 00:00 [accepted] PHST- 2017/06/16 06:00 [pubmed] PHST- 2018/02/27 06:00 [medline] PHST- 2017/06/16 06:00 [entrez] AID - archdischild-2017-312922 [pii] AID - 10.1136/archdischild-2017-312922 [doi] PST - ppublish SO - Arch Dis Child Fetal Neonatal Ed. 2018 Mar;103(2):F107-F111. doi: 10.1136/archdischild-2017-312922. Epub 2017 Jun 14. PMID- 30453640 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 11 IP - 11 DP - 2018 Nov 17 TI - The Out-of-Plane Compression Behavior of Cross-Ply AS4/PEEK Thermoplastic Composite Laminates at High Strain Rates. LID - 10.3390/ma11112312 [doi] LID - 2312 AB - The dynamic mechanical behavior of thermoplastic composites over a wide range of strain rates has become an important research topic for extreme environmental survivability in the fields of military protection, aircraft safety, and aerospace engineering. However, the dynamic compression response in the out-of-plane direction, which is one of the most important loading conditions resulting in the damage of composite materials, has not been investigated thoroughly when compared to in-plane compression and tensile behavior under high strain rates. Thus, we used split Hopkinson pressure bar (SHPB) tests to conduct the out-of-plane compression test of cross-ply carbon fiber-reinforced polyetheretherketone (AS4/PEEK) composite laminates. Afterward, the damage mechanism under different strain rates was characterized by the macrostructure morphologies and scanning electron microscope micrographs. Two major cases of the incomplete failure condition and complete failure condition were discussed. Dynamic stress-strain curves expound the strain rates dependencies of elastic modulus, failure strength, and failure strain. An obvious spring-back process could be observed under incomplete failure tests. For the complete failure tests, secondary loading could be observed by reconstructing and comparing the dynamic response history. Lastly, various failure modes that occurred in different loading strain rates illustrate that the damage mechanism also shows obvious strain rate sensitivity. FAU - Zou, Huiran AU - Zou H AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. zouhr2015@gmail.com. FAU - Yin, Weilong AU - Yin W AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. ywl@hit.edu.cn. FAU - Cai, Chaocan AU - Cai C AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. C39008@163.com. FAU - Wang, Bing AU - Wang B AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. wangbing86@hit.edu.cn. FAU - Liu, Ankang AU - Liu A AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. liuankang1993@126.com. FAU - Yang, Zhen AU - Yang Z AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. zhen940729@163.com. FAU - Li, Yibin AU - Li Y AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. liyibin@hit.edu.cn. FAU - He, Xiaodong AU - He X AD - Center for Composite Materials and Structures, Harbin Institute of Technology, Harbin 150080, China. Hexd@hit.edu.cn. LA - eng GR - NSFC 11272109/National Natural Science Foundation of China/ GR - 20122302110065/Ph. D. Programs Foundation of Ministry of Education of China/ PT - Journal Article DEP - 20181117 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC6265749 OTO - NOTNLM OT - AS4/PEEK laminates OT - SHPB test OT - compression properties OT - high strain rate OT - thermoplastic COIS- The authors declare no conflict of interest. EDAT- 2018/11/21 06:00 MHDA- 2018/11/21 06:01 PMCR- 2018/11/17 CRDT- 2018/11/21 06:00 PHST- 2018/10/12 00:00 [received] PHST- 2018/11/07 00:00 [revised] PHST- 2018/11/14 00:00 [accepted] PHST- 2018/11/21 06:00 [entrez] PHST- 2018/11/21 06:00 [pubmed] PHST- 2018/11/21 06:01 [medline] PHST- 2018/11/17 00:00 [pmc-release] AID - ma11112312 [pii] AID - materials-11-02312 [pii] AID - 10.3390/ma11112312 [doi] PST - epublish SO - Materials (Basel). 2018 Nov 17;11(11):2312. doi: 10.3390/ma11112312. PMID- 28303708 OWN - NLM STAT- MEDLINE DCOM- 20170629 LR - 20170629 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 68 IP - 1 DP - 2017 TI - The assessment of the ionizing radiation dose received by patients during some diagnostic X-ray examinations carried out on the basis of the working procedures in the health care entities. PG - 99-103 AB - BACKGROUND: X-ray examination is a popular and universally used injury and disease diagnostic method. A distinctive X ray examination feature is that it can be done quickly which is extremely important in case of the need for rapid diagnosis of patients in life threatening condition. Another advantage of the X-ray examinations is also relatively low cost of carry. However, X-ray examination involve adverse health effects. During the examination the patient is subjected to ionizing radiation that might have impact on his health. OBJECTIVE: The aim of this study has been to determine and assess the size of the entrance surface doses (ESD) received by patients during selected X-ray examinations performed on the basis of the medical working procedures available in healthcare entities in Masovian Voivodeship in Poland. MATERIALS AND METHOD: The examinations were conducted for 71 X-ray units located in the Masovian Voivodeship. Measurements of doses received by the patients were based on our own validated test methods. RESULTS: It was found that the range applied to the high voltage in healthcare entities does not always coincide with the values specified in the standard procedures. It was found in the skull projection radiography AP and LAT that the recorded values were from range 60 to 82 kV (the average value of 74 kV) while in accordance with a standard procedure they should be in the range from 65 to 75 kV. Only in case of cervical spine radiography in the AP projection, the LAT exposure conditions were matching with the standard obligatory procedures in Poland. The consequence of selecting exposure conditions are significant differences in the size of the doses the patient receive during the same medical procedures. The greatest range of ESD doses was found during radiography of the thoracic spine in the projection AP and LAT. The projection LAT measured values were in the range of 523 to 10550 μGy (average value 2175 μGy). CONCLUSIONS: It is necessary to update immediately the standard procedures and to develop detailed guidelines for the preparation of working procedures in X-ray rooms. FAU - Bekas, Marcin AU - Bekas M AD - National Institute of Public Health – National Institute of Hygiene, Department of Radiation Hygiene and Radiobiology, Warsaw, Poland FAU - Waśniewska, Elżbieta AU - Waśniewska E AD - National Institute of Public Health – National Institute of Hygiene, Department of Radiation Hygiene and Radiobiology, Warsaw, Poland FAU - Wardziński, Adam AU - Wardziński A AD - National Institute of Public Health – National Institute of Hygiene, Department of Radiation Hygiene and Radiobiology, Warsaw, Poland FAU - Wieprzowski, Kamil AU - Wieprzowski K AD - National Institute of Public Health – National Institute of Hygiene, Department of Radiation Hygiene and Radiobiology, Warsaw, Poland LA - eng PT - Journal Article PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 RN - 0 (Radiopharmaceuticals) SB - IM MH - Body Burden MH - Environmental Exposure/analysis MH - Environmental Monitoring/statistics & numerical data MH - Equipment Safety/*standards MH - Humans MH - Patient Safety/*statistics & numerical data MH - Poland MH - Radiation Monitoring/*standards/*statistics & numerical data MH - Radioactive Hazard Release/prevention & control MH - Radiography/*standards MH - Radiopharmaceuticals/*adverse effects EDAT- 2017/03/18 06:00 MHDA- 2017/07/01 06:00 CRDT- 2017/03/18 06:00 PHST- 2017/03/18 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] PHST- 2017/03/18 06:00 [entrez] PST - ppublish SO - Rocz Panstw Zakl Hig. 2017;68(1):99-103. PMID- 15129201 OWN - NLM STAT- MEDLINE DCOM- 20040826 LR - 20131121 IS - 0161-4754 (Print) IS - 0161-4754 (Linking) VI - 27 IP - 3 DP - 2004 Mar-Apr TI - Effect of a back belt on reaching postures. PG - 186-96 AB - OBJECTIVE: The present study investigated the effect of a back belt on reach actions. SUBJECTS: Sixteen undergraduate college students (8 male students, 8 female students) ranging in age from 18 to 22 years. Thirteen subjects were included in the final analysis. SETTING: The Department of Psychology at Miami University, Oxford, Ohio METHODS: Using a well-established set of procedures developed in our laboratory for studying reaching, seated adult participants reached for and retrieved an object placed at various distances from them. Reach distances included values both closer than and farther than each subject's maximum seated reach. The reach task had 2 conditions: picking up and retrieving a small block and skewering and retrieving a small bead with a needle. For each task condition, each subject either wore the belt or did not use a belt. RESULTS: Results indicate that when subjects wore the belt while reaching, they tended to have initial transition points (sitting to nonsitting) closer to their bodies than while not wearing the belt. That is, for a distant object, subjects were more likely to raise their bodies out of the chair rather than perform an extreme seated reach, possibly acting to preserve a greater margin of safety. CONCLUSIONS: The back belt consistently modified reaching postures by limiting extreme ranges of motion during a task that required enhanced stability. Furthermore, the methodology and analysis presented in this article when applied to chiropractic will allow us to begin thoughtful investigation of the effects of chiropractic adjustments on postural transitions and margin of safety. FAU - Smith, Dean L AU - Smith DL AD - Center for Ergonomic Research, Department of Psychology, Miami University, Oxford, Ohio, USA. drdean@essenceofwellness.com FAU - Dainoff, Marvin J AU - Dainoff MJ FAU - Mark, Leonard S AU - Mark LS FAU - Oates, Shawn P AU - Oates SP FAU - Davis, Niles C AU - Davis NC LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Manipulative Physiol Ther JT - Journal of manipulative and physiological therapeutics JID - 7807107 SB - IM MH - Adult MH - Analysis of Variance MH - Biomechanical Phenomena MH - Chiropractic/*standards MH - Female MH - Humans MH - Lumbosacral Region/physiology MH - Male MH - Manipulation, Chiropractic/standards MH - Movement/physiology MH - Ohio MH - *Orthotic Devices/standards MH - *Posture MH - *Protective Devices/standards MH - *Range of Motion, Articular EDAT- 2004/05/07 05:00 MHDA- 2004/08/27 05:00 CRDT- 2004/05/07 05:00 PHST- 2004/05/07 05:00 [pubmed] PHST- 2004/08/27 05:00 [medline] PHST- 2004/05/07 05:00 [entrez] AID - S0161475403002501 [pii] AID - 10.1016/j.jmpt.2003.12.028 [doi] PST - ppublish SO - J Manipulative Physiol Ther. 2004 Mar-Apr;27(3):186-96. doi: 10.1016/j.jmpt.2003.12.028. PMID- 25190632 OWN - NLM STAT- MEDLINE DCOM- 20151023 LR - 20181202 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 73 DP - 2014 Dec TI - Investigation of time and weather effects on crash types using full Bayesian multivariate Poisson lognormal models. PG - 91-9 LID - S0001-4575(14)00251-6 [pii] LID - 10.1016/j.aap.2014.08.014 [doi] AB - Previous research shows that various weather elements have significant effects on crash occurrence and risk; however, little is known about how these elements affect different crash types. Consequently, this study investigates the impact of weather elements and sudden extreme snow or rain weather changes on crash type. Multivariate models were used for seven crash types using five years of daily weather and crash data collected for the entire City of Edmonton. In addition, the yearly trend and random variation of parameters across the years were analyzed by using four different modeling formulations. The proposed models were estimated in a full Bayesian context via Markov Chain Monte Carlo simulation. The multivariate Poisson lognormal model with yearly varying coefficients provided the best fit for the data according to Deviance Information Criteria. Overall, results showed that temperature and snowfall were statistically significant with intuitive signs (crashes decrease with increasing temperature; crashes increase as snowfall intensity increases) for all crash types, while rainfall was mostly insignificant. Previous snow showed mixed results, being statistically significant and positively related to certain crash types, while negatively related or insignificant in other cases. Maximum wind gust speed was found mostly insignificant with a few exceptions that were positively related to crash type. Major snow or rain events following a dry weather condition were highly significant and positively related to three crash types: Follow-Too-Close, Stop-Sign-Violation, and Ran-Off-Road crashes. The day-of-the-week dummy variables were statistically significant, indicating a possible weekly variation in exposure. Transportation authorities might use the above results to improve road safety by providing drivers with information regarding the risk of certain crash types for a particular weather condition. CI - Copyright © 2014 Elsevier Ltd. All rights reserved. FAU - El-Basyouny, Karim AU - El-Basyouny K AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, Canada T6G 2W2. Electronic address: karim.el-basyouny@ualberta.ca. FAU - Barua, Sudip AU - Barua S AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, Canada T6G 2W2. Electronic address: barua1@ualberta.ca. FAU - Islam, Md Tazul AU - Islam MT AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, AB, Canada T6G 2W2. Electronic address: mdtazul@ualberta.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140903 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*statistics & numerical data MH - Bayes Theorem MH - Humans MH - Markov Chains MH - Models, Theoretical MH - Monte Carlo Method MH - *Rain MH - Risk MH - Safety MH - *Snow MH - Wind OTO - NOTNLM OT - Full Bayesian estimation OT - Markov Chain Monte Carlo (MCMC) OT - Poisson lognormal regression OT - Random parameters OT - Weather elements EDAT- 2014/09/06 06:00 MHDA- 2015/10/24 06:00 CRDT- 2014/09/06 06:00 PHST- 2014/02/14 00:00 [received] PHST- 2014/07/15 00:00 [revised] PHST- 2014/08/16 00:00 [accepted] PHST- 2014/09/06 06:00 [entrez] PHST- 2014/09/06 06:00 [pubmed] PHST- 2015/10/24 06:00 [medline] AID - S0001-4575(14)00251-6 [pii] AID - 10.1016/j.aap.2014.08.014 [doi] PST - ppublish SO - Accid Anal Prev. 2014 Dec;73:91-9. doi: 10.1016/j.aap.2014.08.014. Epub 2014 Sep 3. PMID- 12287020 OWN - PIP STAT- MEDLINE DCOM- 19940503 LR - 20071115 IS - 0953-9182 (Print) IS - 0953-9182 (Linking) VI - 4 IP - 3 DP - 1992 Jul TI - Oral contraception: where do we stand? PG - 148-53 FAU - Diczfalusy, E AU - Diczfalusy E LA - eng PT - Journal Article PL - England TA - Contemp Rev Obstet Gynaecol JT - Contemporary reviews in obstetrics and gynaecology JID - 8908156 RN - 0 (Contraceptive Agents) RN - 0 (Contraceptive Agents, Female) RN - 0 (Contraceptives, Oral) RN - 0 (Hemoglobins) MH - *Abortion, Induced MH - Biology MH - Blood MH - *Breast Neoplasms MH - *Cerebrovascular Circulation MH - Communication MH - Contraception MH - Contraceptive Agents MH - Contraceptive Agents, Female MH - *Contraceptives, Oral MH - Demography MH - *Developed Countries MH - *Developing Countries MH - Disease MH - *Dysmenorrhea MH - Economics MH - Embolism MH - *Endometrial Neoplasms MH - Evaluation Studies as Topic MH - Family Planning Services MH - *Health Services Needs and Demand MH - Heart Diseases MH - *Hemoglobins MH - *Infant Mortality MH - *Injections MH - *Liver Neoplasms MH - *Mass Media MH - *Maternal Mortality MH - Menstruation Disturbances MH - *Morbidity MH - Mortality MH - *Myocardial Infarction MH - Neoplasms MH - *Ovarian Cysts MH - *Ovarian Neoplasms MH - Physiology MH - Population MH - Population Dynamics MH - *Risk Assessment MH - *Risk Factors MH - *Thromboembolism MH - *Uterine Cervical Neoplasms MH - Vascular Diseases OID - PIP: 082252 OID - POP: 00226877 OAB - The place of steroidal and oral contraceptives (OCs) in the broad scheme of reproductive health worldwide is evaluated. After 30 years, about 70 million couples are using steroidal contraception, out of about 380 million contracepting couples and another 380 not using family planning. The public debate about the safety of OCs is skewed by peoples; inability to appreciate concepts of relative risk, attributable risk, risk-benefit ration, and the probabilistic nature of the growth of scientific knowledge. Nevertheless, people deserve access to objective, sound information about contraceptive choices. There are several established benefits of OCs prevention of pregnancy; control of irregular menstrual bleeding; and reduction of dysmenorrhea, iron deficiency anemia, benign breast disease, pelvic inflammatory disease, functional ovarian cysts, and endometrial ovarian cancer. Several possible benefits are likely, such as less bone loss. The established risks of OCs are: rare myocardial infarction, stroke, venous thromboembolism, and liver tumor. Possible risks include breast and cervical cancer. For most of these conditions, existing evidence suggests that the trends found in studies in developed countries can be applied to developing countries. The main differences are in disorders with widely different attributable risks, such as liver tumors, which are extremely rare, but much more common in developing countries. Current overall assessments conclude that the benefits of taking OCs far outweigh the risks in developed countries and are profoundly more life-saving in developing countries, where maternal mortality and morbidity due to pregnancy are many times higher. In these areas, there are 400 million couples with no access to family planning, 140 million who conceived unwanted pregnancies in 1988, and 30-50 million who have abortions. In addition, 95% of all infant deaths and 99% of maternal deaths occur in developing countries. OABL- eng OTO - PIP OT - *Abortion, Induced OT - Biology OT - *Breast Cancer OT - Cancer OT - *Cerebrovascular Effects OT - *Cervical Cancer OT - Communication OT - Contraception OT - Contraceptive Agents OT - Contraceptive Agents, Female OT - *Contraceptive Agents, Progestin OT - Contraceptive Methods--beneficial effects OT - Contraceptive Methods--side effects OT - Demographic Factors OT - *Developed Countries OT - *Developing Countries OT - Diseases OT - *Dysmenorrhea OT - Economic Factors OT - Embolism OT - *Endometrial Cancer OT - Evaluation OT - Family Planning OT - Fertility Control, Postconception OT - Heart Diseases OT - Hemic System OT - *Hemoglobin Level OT - *Infant Mortality OT - *Injectables OT - *Liver Neoplasms OT - *Mass Media OT - *Maternal Mortality OT - Menstruation Disorders OT - *Morbidity OT - Mortality OT - *Myocardial Infarction OT - *Needs OT - Neoplasms OT - *Oral Contraceptives--beneficial effects OT - *Oral Contraceptives--side effects OT - *Ovarian Cancer OT - *Ovarian Cysts OT - Physiology OT - Population OT - Population Dynamics OT - *Risk Assessment OT - *Risk Factors OT - *Thromboembolism OT - Vascular Diseases OT - *World GN - PIP: TJ: CONTEMPORARY REVIEWS IN OBSTETRICS AND GYNAECOLOGY EDAT- 1992/07/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1992/07/01 00:00 PHST- 1992/07/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1992/07/01 00:00 [entrez] PST - ppublish SO - Contemp Rev Obstet Gynaecol. 1992 Jul;4(3):148-53. PMID- 30762429 OWN - NLM STAT- MEDLINE DCOM- 20200730 LR - 20200730 IS - 1557-8070 (Electronic) IS - 1531-1074 (Print) IS - 1557-8070 (Linking) VI - 19 IP - 8 DP - 2019 Aug TI - Biological Contamination Prevention for Outer Solar System Moons of Astrobiological Interest: What Do We Need to Know? PG - 951-974 LID - 10.1089/ast.2018.1996 [doi] AB - To ensure that scientific investments in space exploration are not compromised by terrestrial contamination of celestial bodies, special care needs to be taken to preserve planetary conditions for future astrobiological exploration. Significant effort has been made and is being taken to address planetary protection in the context of inner Solar System exploration. In particular for missions to Mars, detailed internationally accepted guidelines have been established. For missions to the icy moons in the outer Solar System, Europa and Enceladus, the planetary protection requirements are so far based on a probabilistic approach and a conservative estimate of poorly known parameters. One objective of the European Commission-funded project, Planetary Protection of Outer Solar System, was to assess the existing planetary protection approach, to identify inherent knowledge gaps, and to recommend scientific investigations necessary to update the requirements for missions to the icy moons. FAU - Rettberg, Petra AU - Rettberg P AD - 1Research Group Astrobiology, Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Köln, Germany. FAU - Antunes, André AU - Antunes A AD - 2GEMM-Group for Extreme and Marine Microbiology, Department of Biology, Edge Hill University, Ormskirk, United Kingdom. FAU - Brucato, John AU - Brucato J AD - 3Department of Physics and Astronomy, Astrophysical Observatory of Arcetri, National Institute for Astrophysics (INAF), Florence, Italy. FAU - Cabezas, Patricia AU - Cabezas P AD - 4Science Connect-European Science Foundation (ESF), Strasbourg, France. FAU - Collins, Geoffrey AU - Collins G AD - 5Department of Physics and Astronomy, Wheaton College, Massachusetts, Norton, Massachusetts. FAU - Haddaji, Alissa AU - Haddaji A AD - 6Committee on Space Research (COSPAR), Montpellier, France. FAU - Kminek, Gerhard AU - Kminek G AD - 6Committee on Space Research (COSPAR), Montpellier, France. FAU - Leuko, Stefan AU - Leuko S AD - 1Research Group Astrobiology, Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Köln, Germany. FAU - McKenna-Lawlor, Susan AU - McKenna-Lawlor S AD - 7Space Technology Ireland Ltd., Maynooth, Ireleand. FAU - Moissl-Eichinger, Christine AU - Moissl-Eichinger C AD - 8Department of Internal Medicine, Medical University of Graz, Graz, Austria. FAU - Fellous, Jean-Louis AU - Fellous JL AD - 5Department of Physics and Astronomy, Wheaton College, Massachusetts, Norton, Massachusetts. FAU - Olsson-Francis, Karen AU - Olsson-Francis K AD - 9Faculty of Science, Technology, Engineering & Mathematics, School of Environment, Earth & Ecosystem Sciences, The Open University, Milton Keynes, United Kingdom. FAU - Pearce, David AU - Pearce D AD - 10Department of Applied Sciences, Northumbria University, Newcastle, United Kingdom. FAU - Rabbow, Elke AU - Rabbow E AD - 1Research Group Astrobiology, Radiation Biology Department, German Aerospace Center (DLR), Institute of Aerospace Medicine, Köln, Germany. FAU - Royle, Samuel AU - Royle S AD - 11Faculty of Engineering, Department of Earth Science & Engineering, Imperial College, London, United Kingdom. FAU - Saunders, Mark AU - Saunders M AD - 12Independent Consultant for the US National Academies of Sciences (NAS), Washington, District of Columbia. FAU - Sephton, Mark AU - Sephton M AD - 11Faculty of Engineering, Department of Earth Science & Engineering, Imperial College, London, United Kingdom. FAU - Spry, Andy AU - Spry A AD - 13Carl Sagan Center, SETI, Mountain View, California. FAU - Walter, Nicolas AU - Walter N AD - 4Science Connect-European Science Foundation (ESF), Strasbourg, France. FAU - Wimmer Schweingruber, Robert AU - Wimmer Schweingruber R AD - 14Institut für Experimentelle und Angewandte Physik, Abteilung Extraterrestrische Physik, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. FAU - Treuet, Jean-Charles AU - Treuet JC AD - 15Eurospace, Paris, France. LA - eng PT - Journal Article DEP - 20190214 PL - United States TA - Astrobiology JT - Astrobiology JID - 101088083 RN - 0 (Ice) SB - IM MH - *Containment of Biohazards MH - *Exobiology MH - *Extraterrestrial Environment MH - Genomics MH - Ice MH - Microbial Viability MH - Microbiota MH - *Moon MH - Planets MH - Sterilization MH - Vacuum PMC - PMC6767865 OTO - NOTNLM OT - Enceladus OT - Europa OT - Icy moons OT - Planetary protection OT - Requirements OT - Spacecraft COIS- No competing financial interests exist. EDAT- 2019/02/15 06:00 MHDA- 2020/07/31 06:00 PMCR- 2019/07/29 CRDT- 2019/02/15 06:00 PHST- 2019/02/15 06:00 [pubmed] PHST- 2020/07/31 06:00 [medline] PHST- 2019/02/15 06:00 [entrez] PHST- 2019/07/29 00:00 [pmc-release] AID - 10.1089/ast.2018.1996 [pii] AID - 10.1089/ast.2018.1996 [doi] PST - ppublish SO - Astrobiology. 2019 Aug;19(8):951-974. doi: 10.1089/ast.2018.1996. Epub 2019 Feb 14. PMID- 33061669 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220417 IS - 1179-142X (Print) IS - 1179-142X (Electronic) IS - 1179-142X (Linking) VI - 13 DP - 2020 TI - Persistent Left Superior Vena Cava Identified After Hemodialysis Catheter Insertion: A Case Report. PG - 465-469 LID - 10.2147/IMCRJ.S266858 [doi] AB - INTRODUCTION: Central venous catheter (CVC) insertion is the most commonly performed clinical procedure when a patient initiates hemodialysis. Despite its clinical benefits, CVC insertion has several risks of complications. Thrombosis, venous stenosis, infection, arrhythmia, pneumothorax, and bleeding are among these complications. Malposition of the tip of the CVC can also occur with an incidence of up to 7%. One of several factors that could contribute to malposition is venous anatomy variation. Persistent left superior vena cava (PLSVC) is an extremely rare venous anatomical disorder but might have a significant clinical impact. CASE PRESENTATION: Here we report a PLSVC case that was identified in chest radiography after the insertion of a CVC catheter in a patient with end-stage renal disease (ESRD). A 40-year-old woman with a history of type 2 diabetes mellitus, hypertension, dyslipidemia, and obesity was presented in the emergency room with dyspnea for 1 week. Acute hemodialysis was required because of the ESRD and pulmonary edema. The PLSVC condition accompanied by various complications that occurred in this patient became a dilemma for the nephrologist in determining the diagnosis and proper CVC management. DISCUSSION: PLSVC is the most common congenital abnormality of the vena cava, even though it has a very small incidence. PLSVC occurs in about 0.1-0.5% of the total population and reaches 10% in individuals with congenital heart abnormalities. Most PLSVC presents along with normal superior vena cava and drains into the right atrium, which makes it very difficult to see the clinical signs and symptoms. Almost all PLSVC conditions are found incidentally during or after invasive procedures such as CVC insertion. CVC insertion in the PLSVC condition needs proper management to minimize the risk of complications. CONCLUSION: This case shows the importance of understanding the PLSVC condition, which, although very rare, is expected to increase the awareness of the nephrologist in making the diagnosis, determining appropriate management, and preventing complications, thereby improving patient safety. CI - © 2020 Puspitasari et al. FAU - Puspitasari, Metalia AU - Puspitasari M AUID- ORCID: 0000-0002-8884-4579 AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Sinorita, Hemi AU - Sinorita H AD - Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Bagaswoto, Hendry Purnasidha AU - Bagaswoto HP AD - Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Kuswadi, Iri AU - Kuswadi I AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Prasanto, Heru AU - Prasanto H AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Wardhani, Yulia AU - Wardhani Y AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. FAU - Kurniawan, Wahyu Tri AU - Kurniawan WT AUID- ORCID: 0000-0001-6503-8104 AD - Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada - Dr. Sardjito Hospital, Yogyakarta, Indonesia. LA - eng PT - Case Reports PT - Journal Article DEP - 20201001 PL - New Zealand TA - Int Med Case Rep J JT - International medical case reports journal JID - 101566269 PMC - PMC7534844 OTO - NOTNLM OT - CVC OT - ESRD OT - PLSVC OT - central venous catheter OT - end-stage renal disease OT - hemodialysis OT - malposition OT - persistent left superior vena cava COIS- The authors report no conflicts of interest in this work. EDAT- 2020/10/17 06:00 MHDA- 2020/10/17 06:01 PMCR- 2020/10/01 CRDT- 2020/10/16 05:51 PHST- 2020/06/10 00:00 [received] PHST- 2020/08/22 00:00 [accepted] PHST- 2020/10/16 05:51 [entrez] PHST- 2020/10/17 06:00 [pubmed] PHST- 2020/10/17 06:01 [medline] PHST- 2020/10/01 00:00 [pmc-release] AID - 266858 [pii] AID - 10.2147/IMCRJ.S266858 [doi] PST - epublish SO - Int Med Case Rep J. 2020 Oct 1;13:465-469. doi: 10.2147/IMCRJ.S266858. eCollection 2020. PMID- 24243091 OWN - NLM STAT- MEDLINE DCOM- 20140930 LR - 20211021 IS - 1097-0274 (Electronic) IS - 0271-3586 (Print) IS - 0271-3586 (Linking) VI - 57 IP - 2 DP - 2014 Feb TI - Gender specific analysis of occupational diseases of the low back caused by carrying, lifting or extreme trunk flexion--use of a prevention index to identify occupations with high prevention needs. PG - 233-44 LID - 10.1002/ajim.22277 [doi] AB - BACKGROUND: Gender specific analysis of the occupational disease of the lumbar spine caused by carrying, lifting, or extreme trunk flexion in Germany (OD No.2108) with the aim to identify areas of focus for prevention and research with a prevention index (PI). METHODS: Data from the German Statutory Accident Insurance stratified by gender are shown. RESULTS: From 2002 until 2009 there were 2,877 confirmed cases of an OD No. 2108 (40.1% male and 59.1% female). The PI indicated the highest prevention need for female nursing/midwifery associate professionals and male building frame and related trades workers. Patient transfer and working in extremely bent posture were the most frequent exposures. CONCLUSIONS: The identified occupations with high need for prevention among men come from nearly all major occupational groups whereas women cluster in occupational groups from the health and care sectors. CI - © 2013 Wiley Periodicals, Inc. FAU - Thiede, Markus AU - Thiede M AD - Federal Institute for Occupational Safety and Health, Research Unit 3.1 Prevention of Work-Related Disorders, Berlin, Germany. FAU - Liebers, Falk AU - Liebers F FAU - Seidler, Andreas AU - Seidler A FAU - Gravemeyer, Stefan AU - Gravemeyer S FAU - Latza, Ute AU - Latza U LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131116 PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 SB - IM MH - Adolescent MH - Adult MH - Construction Industry MH - Female MH - Germany/epidemiology MH - Humans MH - Incidence MH - Intervertebral Disc Displacement/*epidemiology/etiology/prevention & control MH - Lifting/*adverse effects MH - *Lumbar Vertebrae MH - Male MH - Middle Aged MH - Midwifery MH - Moving and Lifting Patients/adverse effects MH - Nursing MH - Occupational Diseases/*epidemiology/etiology/prevention & control MH - *Posture MH - Risk Factors MH - Sex Factors MH - Young Adult PMC - PMC4225683 OTO - NOTNLM OT - gender OT - lumbar spine OT - occupational disease OT - prevention index EDAT- 2013/11/19 06:00 MHDA- 2014/10/01 06:00 PMCR- 2014/11/10 CRDT- 2013/11/19 06:00 PHST- 2013/10/11 00:00 [accepted] PHST- 2013/11/19 06:00 [entrez] PHST- 2013/11/19 06:00 [pubmed] PHST- 2014/10/01 06:00 [medline] PHST- 2014/11/10 00:00 [pmc-release] AID - 10.1002/ajim.22277 [doi] PST - ppublish SO - Am J Ind Med. 2014 Feb;57(2):233-44. doi: 10.1002/ajim.22277. Epub 2013 Nov 16. PMID- 8280340 OWN - NLM STAT- MEDLINE DCOM- 19940217 LR - 20061115 IS - 0323-4983 (Print) IS - 0323-4983 (Linking) VI - 18 IP - 5 DP - 1993 TI - [Anesthesia before and after curare]. PG - 128-31 AB - Before the advent of curare, muscular relaxation essential for upper abdominal and intrathoracic surgery adequate operating conditions, could only be provided by deep ether or cyclopropane anaesthesia. The required depth of anaesthesia frequently caused severe cardiovascular depression, metabolic and respiratory acidosis and alteration of kidney and liver function. Ether, and especially cyclopropane sensitized the heart to the development of arrhythmias and the danger of explosion was never far away. For fear of anaesthetic mortality essential, life saving operations were often abandoned in poor risk patients. The administration of anaesthesia was more an art, mastered by relatively few, than a science that could be taught to many. It is a tribute to the early masters of anaesthesiology that they were able to carry their patients through the dangers associated with the provision of anaesthesia for major surgical procedures, with relatively low morbidity and mortality. The introduction of curare into anaesthetic practice, by Griffith and Johnson, in 1942, caused profound changes in the efficacy and safety of anaesthesiology. It made possible the development of true balanced anaesthesia, and the elimination of the explosive inhalation anaesthetics and the profound metabolic disturbances associated with their use. The concept of "inoperability," due to severe pathology or extremes of age became obsolete. It would be hard to envisage how open heart, organ transplant and radical brain and cranio-facial surgery could have developed without muscle relaxants.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Foldes, F F AU - Foldes FF AD - Anästhesieabteilung des Albert-Einstein-College of Medicine. LA - ger PT - English Abstract PT - Historical Article PT - Journal Article TT - Anästhesie vor und nach Curare. PL - Germany TA - Anaesthesiol Reanim JT - Anaesthesiologie und Reanimation JID - 7611455 RN - 8063-06-7 (Curare) SB - IM MH - Anesthesiology/*history MH - Curare/*history MH - Europe MH - History, 19th Century MH - History, 20th Century MH - Humans MH - United States EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] PST - ppublish SO - Anaesthesiol Reanim. 1993;18(5):128-31. PMID- 3785004 OWN - NLM STAT- MEDLINE DCOM- 19870122 LR - 20170214 IS - 0094-2405 (Print) IS - 0094-2405 (Linking) VI - 13 IP - 5 DP - 1986 Sep-Oct TI - Potential exposure to metal fumes, particulates, and organic vapors during radiotherapy shielding block fabrication. PG - 748-50 AB - The shielding-block fabrication areas of three hospitals were surveyed to assess inhalation exposure to lead (Pb), cadmium (Cd), bismuth (Bi), and tin (Sn) fumes, as well as styrene and methyl chloride vapors. Area and personal breathing zone samples were collected for various steps in the block fabrication process. Only 3 of 16 air samples for metals resulted in detectable levels of Pb and/or Cd. The levels were well below the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limits, excluding a sample which contained a visible metal fragment. Bi and Sn were not detected in any samples. Methyl chloride and styrene vapors were not detected in any air samples during foam cutting procedures. Total particulates (TP) were measurable in 11 of 17 air samples (ranging from 0.01 to 2.1 mg/m3). TP values were below the OSHA federal standard for nuisance particulates, which is 15 mg/m3. The data suggest that the materials and procedures sampled do not present an inhalation hazard to employees who construct shielding blocks. Precautions should, however, be exercised to prevent exposure under extreme procedural conditions such as soldering or overheating of alloy, and by other means such as ingestion. Care should also be taken during cleanup or housekeeping to prevent re-entrainment into the work atmosphere of mechanically generated metal particles or materials condensed within melting pots (which may be high in metal content). FAU - DeMeyer, C L AU - DeMeyer CL FAU - Whitehead, L W AU - Whitehead LW FAU - Jacobson, A P AU - Jacobson AP FAU - Brown, D G AU - Brown DG LA - eng PT - Journal Article PL - United States TA - Med Phys JT - Medical physics JID - 0425746 RN - 0 (Air Pollutants, Occupational) RN - 0 (Alloys) RN - 0 (Metals) SB - IM MH - Air Pollutants, Occupational/adverse effects MH - Alloys/adverse effects MH - Humans MH - Maximum Allowable Concentration MH - Metals/*adverse effects MH - Radiation Protection/*instrumentation MH - Radiotherapy MH - Safety MH - United States MH - United States Occupational Safety and Health Administration EDAT- 1986/09/01 00:00 MHDA- 1986/09/01 00:01 CRDT- 1986/09/01 00:00 PHST- 1986/09/01 00:00 [pubmed] PHST- 1986/09/01 00:01 [medline] PHST- 1986/09/01 00:00 [entrez] AID - 10.1118/1.595841 [doi] PST - ppublish SO - Med Phys. 1986 Sep-Oct;13(5):748-50. doi: 10.1118/1.595841. PMID- 38854559 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240611 IS - 2470-1343 (Electronic) IS - 2470-1343 (Linking) VI - 9 IP - 22 DP - 2024 Jun 4 TI - Study on the Impact Failure Rules of Roadway Floor Induced by Dynamic Load Disturbance under Extremely Thick Conglomerate. PG - 23542-23554 LID - 10.1021/acsomega.4c00736 [doi] AB - The dynamic load resulting from the fracture of extremely thick rock layers directly influences the surrounding rock layers within stopes and roadways, thereby inducing rockburst disasters. Hence, studying the tunnel floor's impact and ground pressure induced by dynamic load disturbance under extremely thick conglomerates is crucial. This study focuses on the 23130 working face of Yuejin Coal Mine as its engineering background. Initially, through similar simulation experiments, the impact characteristics of dynamic load disturbance positions under thick conglomerates on tunnel bottom damage are investigated. Building upon this foundation, finite element numerical simulation is employed to explore the further conglomerate thickness' impact on tunnel floor damage under dynamic load disturbance. Lastly, the accuracy of similar and numerical simulation results is validated by incorporating field examples. Findings reveal that dynamic load disturbance leads to an instantaneous increase in coal and rock mass acceleration in the roof and floor of roadways, followed by a decrease to an equilibrium state, thereby subjecting the interior to high static load conditions. The thickness of conglomerate in the overlying rock layer emerges as a crucial factor affecting tunnel floor rockburst incidents. With dynamic load disturbance, as conglomerate thickness increases, the stress concentration area of the tunnel floor gradually shifts to deeper rock strata. Effective control of tunnel floor rockbursts can be achieved by implementing support measures like anchor rods and cables and managing tunnel deformation and damage under dynamic loads. Dynamic load disturbance under extremely thick conglomerates emerges as a pivotal condition for inducing tunnel floor impact damage. This study provides a theoretical foundation for the safe excavation of similar mine tunnels and for implementing rockburst prevention and control measures. CI - © 2024 The Authors. Published by American Chemical Society. FAU - Xu, Xuefeng AU - Xu X AUID- ORCID: 0009-0006-6058-5970 AD - School of Energy Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, People's Republic of China. AD - Key Laboratory of Green and Efficient Mining and Comprehensive Utilization of Mineral Resources in Henan Province, Henan Polytechnic University, Jiaozuo 454000, People's Republic of China. FAU - Dai, Zuo AU - Dai Z AD - School of Energy Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, People's Republic of China. AD - Key Laboratory of Green and Efficient Mining and Comprehensive Utilization of Mineral Resources in Henan Province, Henan Polytechnic University, Jiaozuo 454000, People's Republic of China. FAU - Xu, Hao AU - Xu H AD - College of Safety and Environmental Engineering, Shandong University of Science and Technology, Qingdao 266590, People's Republic of China. LA - eng PT - Journal Article DEP - 20240524 PL - United States TA - ACS Omega JT - ACS omega JID - 101691658 PMC - PMC11154898 COIS- The authors declare no competing financial interest. EDAT- 2024/06/10 06:42 MHDA- 2024/06/10 06:43 PMCR- 2024/05/24 CRDT- 2024/06/10 05:23 PHST- 2024/01/22 00:00 [received] PHST- 2024/05/16 00:00 [revised] PHST- 2024/05/17 00:00 [accepted] PHST- 2024/06/10 06:43 [medline] PHST- 2024/06/10 06:42 [pubmed] PHST- 2024/06/10 05:23 [entrez] PHST- 2024/05/24 00:00 [pmc-release] AID - 10.1021/acsomega.4c00736 [doi] PST - epublish SO - ACS Omega. 2024 May 24;9(22):23542-23554. doi: 10.1021/acsomega.4c00736. eCollection 2024 Jun 4. PMID- 9853391 OWN - NLM STAT- MEDLINE DCOM- 19990125 LR - 20191024 IS - 0272-4332 (Print) IS - 0272-4332 (Linking) VI - 18 IP - 5 DP - 1998 Oct TI - Rating threat mitigators: faith in experts, governments, and individuals themselves to create a safer world. PG - 547-56 AB - This research explores public judgments about the threat-reducing potential of experts, individual behavior, and government spending. The data are responses of a national sample of 1225 to mail surveys that include measures of several dimensions of public judgments about violent crime, automobile accidents, hazardous chemical waste, air pollution, water pollution, global warming, AIDS, heart disease, and cancer. Beliefs about who can best mitigate threats are specific to classes of threats. In general, there is little faith that experts can do much about violent crime and automobile accidents, moderate faith in their ability to address problems of global warming, and greater expectations for expert solutions to the remaining threats. People judge individual behavior as effective in reducing the threats of violent crime, AIDS, heart disease, and automobile accidents but less so for the remaining threats. Faith in more government spending is highest for AIDS and the other two health items, lowest for the trio of violent crime, automobile accidents, and global warming, and moderate for the remaining threats. For most threats, people are not distributed at the extremes in judging mitigators. Strong attitudinal and demographic cleavages are also lacking, although some interesting relationships occur. This relative lack of sharp cleavages and the generally moderate opinion indicate ample opportunity for public education and risk communication. FAU - O'Connor, R E AU - O'Connor RE AD - Department of Political Science, Pennsylvania State University, University Park 16802, USA. FAU - Bord, R J AU - Bord RJ FAU - Fisher, A AU - Fisher A LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Risk Anal JT - Risk analysis : an official publication of the Society for Risk Analysis JID - 8109978 SB - IM MH - Adult MH - Humans MH - Perception MH - Public Opinion MH - *Risk MH - Risk-Taking MH - Safety MH - Surveys and Questionnaires MH - United States EDAT- 1998/12/16 00:00 MHDA- 1998/12/16 00:01 CRDT- 1998/12/16 00:00 PHST- 1998/12/16 00:00 [pubmed] PHST- 1998/12/16 00:01 [medline] PHST- 1998/12/16 00:00 [entrez] AID - 10.1023/b:rian.0000005929.21712.78 [doi] PST - ppublish SO - Risk Anal. 1998 Oct;18(5):547-56. doi: 10.1023/b:rian.0000005929.21712.78. PMID- 30763484 OWN - NLM STAT- MEDLINE DCOM- 20190305 LR - 20190305 IS - 0026-9050 (Print) IS - 0026-9050 (Linking) VI - 338 IP - 4 DP - 2017 Apr TI - [To the history of the Research and Testing Laboratory of Psychophysiological Support of Flight Operations]. PG - 93-96 AB - The brief history of the first research and testing laboratory (psychophysiological support of flight activity) of the Scientific Research Testing Center (aerospace medicine and military ergonomics) celebrating its 55th anniversary is presented. The laboratory, which is now located in Lipetsk allows specialists of the Research and Testing Center carrying out a wide range of studies on its basis on ergonomic provision of combat effectiveness and flight safety of flight crews, studying the influence of flight work on the pilot's organism and its performance in normal and extreme conditions in close interaction in Highly skilled employees of other institutions of the Ministry of Defense. Tebre. FAU - Zasyadko, K I AU - Zasyadko KI FAU - Vonarshenko, A P AU - Vonarshenko AP FAU - Boreichuk, A F AU - Boreichuk AF FAU - Yazlyuk, M N AU - Yazlyuk MN FAU - Flenov, E A AU - Flenov EA LA - rus PT - Historical Article PT - Journal Article PL - Russia (Federation) TA - Voen Med Zh JT - Voenno-meditsinskii zhurnal JID - 2984871R SB - IM MH - *Aerospace Medicine/history MH - *Aviation MH - History, 20th Century MH - Russia MH - Safety EDAT- 2017/04/01 00:00 MHDA- 2017/04/01 00:01 CRDT- 2019/02/15 06:00 PHST- 2019/02/15 06:00 [entrez] PHST- 2017/04/01 00:00 [pubmed] PHST- 2017/04/01 00:01 [medline] PST - ppublish SO - Voen Med Zh. 2017 Apr;338(4):93-96. PMID- 24673565 OWN - NLM STAT- MEDLINE DCOM- 20150928 LR - 20220310 IS - 1936-086X (Electronic) IS - 1936-0851 (Print) IS - 1936-0851 (Linking) VI - 8 IP - 4 DP - 2014 Apr 22 TI - Bioreducible cationic polymer-based nanoparticles for efficient and environmentally triggered cytoplasmic siRNA delivery to primary human brain cancer cells. PG - 3232-41 LID - 10.1021/nn500704t [doi] AB - siRNA nanomedicines can potentially treat many human diseases, but safe and effective delivery remains a challenge. DNA delivery polymers such as poly(β-amino ester)s (PBAEs) generally cannot effectively deliver siRNA and require chemical modification to enable siRNA encapsulation and delivery. An optimal siRNA delivery nanomaterial needs to be able to bind and self-assemble with siRNA molecules that are shorter and stiffer than plasmid DNA in order to form stable nanoparticles, and needs to promote efficient siRNA release upon entry to the cytoplasm. To address these concerns, we designed, synthesized, and characterized an array of bioreducible PBAEs that self-assemble with siRNA in aqueous conditions to form nanoparticles of approximately 100 nm and that exhibit environmentally triggered siRNA release upon entering the reducing environment of the cytosol. By tuning polymer properties, including bioreducibility and hydrophobicity, we were able to fabricate polymeric nanoparticles capable of efficient gene knockdown (91 ± 1%) in primary human glioblastoma cells without significant cytotoxicity (6 ± 12%). We were also able to achieve significantly higher knockdown using these polymers with a low dose of 5 nM siRNA (76 ± 14%) compared to commercially available reagent Lipofectamine 2000 with a 4-fold higher dose of 20 nM siRNA (40 ± 7%). These bioreducible PBAEs also enabled 63 ± 16% gene knockdown using an extremely low 1 nM siRNA dose and showed preferential transfection of glioblastoma cells versus noncancer neural progenitor cells, highlighting their potential as efficient and tumor-specific carriers for siRNA-based nanomedicine. FAU - Kozielski, Kristen L AU - Kozielski KL AD - Department of Biomedical Engineering, the Institute for Nanobiotechnology, and the Translational Tissue Engineering Center, The Johns Hopkins University School of Medicine , 400 North Broadway/Smith Building Room 5017, Baltimore, Maryland 21231, United States . FAU - Tzeng, Stephany Y AU - Tzeng SY FAU - De Mendoza, Bolivia A Hurtado AU - De Mendoza BA FAU - Green, Jordan J AU - Green JJ LA - eng GR - R01 EB016721/EB/NIBIB NIH HHS/United States GR - T32 CA130840/CA/NCI NIH HHS/United States GR - T32 CA153952/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20140403 PL - United States TA - ACS Nano JT - ACS nano JID - 101313589 RN - 0 (Drug Carriers) RN - 0 (Polymers) RN - 0 (RNA, Small Interfering) RN - 0 (poly(beta-amino ester)) SB - IM MH - Base Sequence MH - Brain Neoplasms/*pathology MH - Cell Line, Tumor MH - Cell Survival/drug effects MH - Cytosol/*metabolism MH - Drug Carriers/*chemistry/toxicity MH - Drug Liberation MH - Humans MH - Nanoparticles/*chemistry/toxicity MH - Oxidation-Reduction MH - Particle Size MH - Polymers/*chemistry MH - RNA, Small Interfering/*chemistry/genetics/*metabolism MH - Safety MH - Transfection PMC - PMC4004313 EDAT- 2014/03/29 06:00 MHDA- 2015/09/29 06:00 PMCR- 2015/03/27 CRDT- 2014/03/29 06:00 PHST- 2014/03/29 06:00 [entrez] PHST- 2014/03/29 06:00 [pubmed] PHST- 2015/09/29 06:00 [medline] PHST- 2015/03/27 00:00 [pmc-release] AID - 10.1021/nn500704t [doi] PST - ppublish SO - ACS Nano. 2014 Apr 22;8(4):3232-41. doi: 10.1021/nn500704t. Epub 2014 Apr 3. PMID- 2407224 OWN - NLM STAT- MEDLINE DCOM- 19900323 LR - 20081121 IS - 0003-9985 (Print) IS - 0003-9985 (Linking) VI - 114 IP - 3 DP - 1990 Mar TI - Current safety of clotting factor concentrates. PG - 335-40 AB - Earlier commercial clotting factor concentrates transmitted hepatitis viruses to 100% and acquired immunodeficiency syndrome viruses to 60% to 80% of patients with hemophilia. Transmission of the human immunodeficiency virus was nearly eliminated by heating concentrates in the lyophilized state, which has been done since 1983. However, human immunodeficiency virus infections were still transmitted by some products "dry heated" under conditions less extreme than 68 degrees C for 72 hours. Newer virus-inactivating procedures include "dry heating" at 80 degrees C for 72 hours, modified heating in n-heptane or water vapor, heating in solution, treatment with solvent-detergent mixtures, monoclonal affinity purification plus inactivation, and alkylation with beta-propiolactone (only for factor IX complex). These procedures have eliminated significant loads of human immunodeficiency virus, hepatitis B virus, and non-A, non-B hepatitis virus in laboratory studies. However, clinical studies have shown transmission of hepatitis non-A, non-B for products "dry heated" except at 80 degrees C and for products heated in n-heptane. Elimination of hepatitis B has been difficult to demonstrate, suggesting a continued need for immunization. FAU - Epstein, J S AU - Epstein JS AD - Division of Blood and Blood Products, Food and Drug Administration, Bethesda, MD 20892. FAU - Fricke, W A AU - Fricke WA LA - eng PT - Journal Article PT - Review PL - United States TA - Arch Pathol Lab Med JT - Archives of pathology & laboratory medicine JID - 7607091 RN - 0 (Blood Coagulation Factors) SB - IM CIN - Arch Pathol Lab Med. 1990 Dec;114(12):1188-9. PMID: 2123621 MH - *Blood Coagulation Factors MH - Chromatography, Affinity/methods MH - HIV/physiology MH - HIV Infections/*prevention & control MH - Hepatitis B/*prevention & control MH - Hepatitis B virus/physiology MH - Hot Temperature MH - Humans MH - Safety RF - 50 EDAT- 1990/03/01 00:00 MHDA- 1990/03/01 00:01 CRDT- 1990/03/01 00:00 PHST- 1990/03/01 00:00 [pubmed] PHST- 1990/03/01 00:01 [medline] PHST- 1990/03/01 00:00 [entrez] PST - ppublish SO - Arch Pathol Lab Med. 1990 Mar;114(3):335-40. PMID- 28665438 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20180719 LR - 20180719 IS - 2040-3372 (Electronic) IS - 2040-3364 (Linking) VI - 9 IP - 27 DP - 2017 Jul 13 TI - Crumpled sheets of reduced graphene oxide as a highly sensitive, robust and versatile strain/pressure sensor. PG - 9581-9588 LID - 10.1039/c7nr02415k [doi] AB - Sensing of mechanical stimuli forms an important communication pathway between humans/environment and machines. The progress in such sensing technology has possible impacts on the functioning of automated systems, human machine interfacing, health-care monitoring, prosthetics and safety systems. The challenges in this field range from attaining high sensitivity to extreme robustness. In this article, sensing of complex mechanical stimuli with a patch of taped crumpled reduced graphene oxide (rGO) has been reported which can typically be assembled under household conditions. The ability of this sensor to detect a wide variety of pressures and strains in conventional day-to-day applications has been demonstrated. An extremely high gauge factor (∼10(3)) at ultralow strains (∼10(-4)) with fast response times (<20.4 ms) could be achieved with such sensors. Pressure resulting from a gentle touch to over human body weight could be sensed successfully. The capability of the sensor to respond in a variety of environments could be exploited in the detection of water and air pressures both below and above atmospheric, with a single device. FAU - Kundu, Subhajit AU - Kundu S AD - Materials Research Centre, Indian Institute of Science, Bangalore, 560012, India. nravi@mrc.iisc.ernet.in. FAU - Sriramdas, Rammohan AU - Sriramdas R FAU - Rafsanjani Amin, Kazi AU - Rafsanjani Amin K FAU - Bid, Aveek AU - Bid A FAU - Pratap, Rudra AU - Pratap R FAU - Ravishankar, Narayanan AU - Ravishankar N LA - eng PT - Journal Article PL - England TA - Nanoscale JT - Nanoscale JID - 101525249 EDAT- 2017/07/01 06:00 MHDA- 2017/07/01 06:01 CRDT- 2017/07/01 06:00 PHST- 2017/07/01 06:00 [pubmed] PHST- 2017/07/01 06:01 [medline] PHST- 2017/07/01 06:00 [entrez] AID - 10.1039/c7nr02415k [doi] PST - ppublish SO - Nanoscale. 2017 Jul 13;9(27):9581-9588. doi: 10.1039/c7nr02415k. PMID- 17487719 OWN - NLM STAT- MEDLINE DCOM- 20070803 LR - 20070509 IS - 1545-9624 (Print) IS - 1545-9624 (Linking) VI - 4 IP - 7 DP - 2007 Jul TI - Using process control concepts to model conditions required for sudden-onset occupational injuries. PG - 467-75 AB - Sudden-onset injury results from a momentary energy exchange between an agent and host, producing immediately discernible tissue damage. These injuries are common in both occupational and nonoccupational settings; typical causes include falls, mechanical contact/crushing, exposure to temperature extremes, and exposure to electrical current. We review epidemiologic and engineering approaches to injury prevention and propose a process control model for describing risk-of-exposure to injury agents during the Pre-event phase of sudden-onset injury. Process control is a proactive approach to quality engineering that is based on the premise of preventing defective products from being manufactured in the first place, instead of relying on reactive inspections to detect defects at the end of the manufacturing process. Principles of process control can be applied by occupational health and safety professionals to prevent workplace injury. The proposed model describes how work activities (process inputs) cause risk-of-exposure to injury agents to fluctuate over the course of a work shift. Risk-of-exposure is a complex function with many input factors including: the nature/magnitude of hazards, the presence and effectiveness of engineering controls, safety climate, management attitudes and practices, the surrounding work environment, the physical and mental states of the worker, and the quality and quantity of supervision and training. Injury can occur only when this function crosses a certain threshold and the host is exposed to injurious energy via physical contact. Certain factors that contribute to risk-of-exposure are stable for extended time periods (weeks, months, years), whereas other factors are transient (durations of minutes or seconds). The model extends classical work by Haddon and others, provides preliminary insights to designing epidemiologic studies and developing fault-tolerant work systems, and illustrates how interdisciplinary approaches can improve our understanding of the etiology of sudden-onset injuries and advancing injury research. FAU - Keyserling, W Monroe AU - Keyserling WM AD - Center for Ergonomics, Department of Industrial and Operations Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA. wmkeyser@umich.edu FAU - Smith, Gordon S AU - Smith GS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - Accidents, Occupational/*prevention & control MH - *Models, Theoretical MH - Occupational Health MH - Risk Assessment MH - Safety Management/*methods MH - Wounds and Injuries/epidemiology/prevention & control EDAT- 2007/05/10 09:00 MHDA- 2007/08/04 09:00 CRDT- 2007/05/10 09:00 PHST- 2007/05/10 09:00 [pubmed] PHST- 2007/08/04 09:00 [medline] PHST- 2007/05/10 09:00 [entrez] AID - 778327215 [pii] AID - 10.1080/15459620701386269 [doi] PST - ppublish SO - J Occup Environ Hyg. 2007 Jul;4(7):467-75. doi: 10.1080/15459620701386269. PMID- 33265163 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240329 IS - 1099-4300 (Electronic) IS - 1099-4300 (Linking) VI - 20 IP - 1 DP - 2018 Jan 21 TI - Adaptive Diagnosis for Rotating Machineries Using Information Geometrical Kernel-ELM Based on VMD-SVD. LID - 10.3390/e20010073 [doi] LID - 73 AB - Rotating machineries often work under severe and variable operation conditions, which brings challenges to fault diagnosis. To deal with this challenge, this paper discusses the concept of adaptive diagnosis, which means to diagnose faults under variable operation conditions with self-adaptively and little prior knowledge or human intervention. To this end, a novel algorithm is proposed, information geometrical extreme learning machine with kernel (IG-KELM). From the perspective of information geometry, the structure and Riemannian metric of Kernel-ELM is specified. Based on the geometrical structure, an IG-based conformal transformation is created to improve the generalization ability and self-adaptability of KELM. The proposed IG-KELM, in conjunction with variation mode decomposition (VMD) and singular value decomposition (SVD) is utilized for adaptive diagnosis: (1) VMD, as a new self-adaptive signal processing algorithm is used to decompose the raw signals into several intrinsic mode functions (IMFs). (2) SVD is used to extract the intrinsic characteristics from the matrix constructed with IMFs. (3) IG-KELM is used to diagnose faults under variable conditions self-adaptively with no requirement of prior knowledge or human intervention. Finally, the proposed method was applied on fault diagnosis of a bearing and hydraulic pump. The results show that the proposed method outperforms the conventional method by up to 7.25% and 7.78% respectively, in percentages of accuracy. FAU - Wang, Zhipeng AU - Wang Z AUID- ORCID: 0000-0003-3039-7582 AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. FAU - Jia, Limin AU - Jia L AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. FAU - Qin, Yong AU - Qin Y AD - State Key Lab of Rail Traffic Control and Safety, Beijing Jiaotong University, Beijing 100044, China. AD - National Engineering Laboratory for System Safety and Operation Assurance of Urban Rail Transit, Guangzhou 510000, China. AD - Beijing Research Center of Urban Traffic Information Sensing and Service Technologies, Beijing Jiaotong University, Beijing 100044, China. LA - eng GR - 2016YFB1200203/National Key R&D Program of China/ GR - RCS2016ZQ003/State Key Laboratory of Rail Traffic Control and Safety/ GR - RCS2016ZT018/State Key Laboratory of Rail Traffic Control and Safety/ PT - Journal Article DEP - 20180121 PL - Switzerland TA - Entropy (Basel) JT - Entropy (Basel, Switzerland) JID - 101243874 PMC - PMC7512271 OTO - NOTNLM OT - fault diagnosis OT - information geometry OT - kernel extreme learning machine OT - variation mode decomposition COIS- The authors declare no conflict of interest. EDAT- 2018/01/21 00:00 MHDA- 2018/01/21 00:01 PMCR- 2018/01/21 CRDT- 2020/12/03 01:03 PHST- 2017/12/06 00:00 [received] PHST- 2018/01/14 00:00 [revised] PHST- 2018/01/16 00:00 [accepted] PHST- 2020/12/03 01:03 [entrez] PHST- 2018/01/21 00:00 [pubmed] PHST- 2018/01/21 00:01 [medline] PHST- 2018/01/21 00:00 [pmc-release] AID - e20010073 [pii] AID - entropy-20-00073 [pii] AID - 10.3390/e20010073 [doi] PST - epublish SO - Entropy (Basel). 2018 Jan 21;20(1):73. doi: 10.3390/e20010073. PMID- 39920189 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250210 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Feb 7 TI - Study on scour simulation and boundary condition conversion technology for a shallow foundation bridge. PG - 4581 LID - 10.1038/s41598-025-86549-z [doi] LID - 4581 AB - Bridges with shallow foundations are highly susceptible to flood scouring due to their limited embedment depth and small contact area between the soil and foundation. This can lead to foundation voids, posing a serious threat to bridge safety. To prevent and mitigate scouring risks, this paper investigates the riverbed scouring characteristics of shallow foundation bridges under different hydrological conditions.The study found that under high water levels and flow velocities, scour depth significantly increased.Under extreme hydrological conditions, a horseshoe vortex forms at the base of the front end of the bridge pier, causing scour pits on both sides of the upstream face of the foundation, which is the main cause of foundation voids that first appear at 2580 s with a maximum scour depth of -2.51 m and a void area of 0.5%, continuing to increase over time.Based on simulated scouring data, this study proposes a method for converting boundary conditions from a scouring model to a mechanical model. This method utilizes point cloud reverse engineering technology to generate a riverbed surface from the three-dimensional coordinate matrix of the boundary and import it into the structural analysis field. Hydraulic effects are calculated using a CFD model and transferred to the structural domain through fluid-structure interaction technology, achieving multi-physical field coupling among water flow, soil, and structure. This method addresses the current limitations in simulating complex scouring forms in bridge flood damage research, providing reliable technical support for subsequent studies on the damage behavior of shallow foundation bridges under flood scouring conditions. CI - © 2025. The Author(s). FAU - Fan, Gangping AU - Fan G AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Li, Huanzhe AU - Li H AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Wang, Tianzhuo AU - Wang T AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Che, Jian AU - Che J AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Li, Xing AU - Li X AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Dou, Chunyang AU - Dou C AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. FAU - Wu, Tong AU - Wu T AD - School of Civil Engineering, Heilongjiang University, Harbin, 150080, China. fgangping@163.com. AD - Longjian Road and Bridge Company Limited, Harbin, 150090, China. fgangping@163.com. LA - eng GR - Grant no. 2022-KYYWF-1055/the Basic Scientific Research Business Expenses of Provincial Universities and Colleges in Heilongjiang Province/ GR - Grant no. 230000100004258230001/Science and technology project of Longjian Road and Bridge Company Limited/ PT - Journal Article DEP - 20250207 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC11805918 OTO - NOTNLM OT - Coupling modeling OT - Foundation void OT - River bed erosion OT - Shallow buried foundation bridge COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/02/08 00:30 MHDA- 2025/02/08 00:31 PMCR- 2025/02/07 CRDT- 2025/02/07 23:17 PHST- 2024/07/01 00:00 [received] PHST- 2025/01/13 00:00 [accepted] PHST- 2025/02/08 00:31 [medline] PHST- 2025/02/08 00:30 [pubmed] PHST- 2025/02/07 23:17 [entrez] PHST- 2025/02/07 00:00 [pmc-release] AID - 10.1038/s41598-025-86549-z [pii] AID - 86549 [pii] AID - 10.1038/s41598-025-86549-z [doi] PST - epublish SO - Sci Rep. 2025 Feb 7;15(1):4581. doi: 10.1038/s41598-025-86549-z. PMID- 30366894 OWN - NLM STAT- MEDLINE DCOM- 20190207 LR - 20201025 IS - 1757-790X (Electronic) IS - 1757-790X (Linking) VI - 2018 DP - 2018 Oct 25 TI - Adult bilateral idiopathic occlusion of foramina of Monro: is foraminoplasty really safe and effective? LID - bcr-2018-226332 [pii] LID - 10.1136/bcr-2018-226332 [doi] LID - bcr2018226332 AB - Idiopathic bilateral occlusion of foramina of Monro is an extremely rare condition in adults and only few cases are reported. Currently, foraminoplasty is indicated as first-line treatment. We reported the case of a 52-year-old woman who presented with headache, instability and urinary incontinence. The imaging demonstrated bilateral occlusion of foramina of Monro and consequent biventricular hydrocephalus. A ventriculo-peritoneal shunt allowed to treat the hydrocephalus, but it was necessary to remove it for the appearance of peritonitis from salpingitis. Since the initial symptomatology reappeared, according to the literature, we performed an endoscopic foraminoplasty with septostomy. The patient immediately developed short-term memory impairment and subsequently we observed the hydrocephalus recurrence. The positioning of a ventriculo-atrial shunt allowed to improve the symptoms, but the memory remained impaired. In case of bilateral true stenosis of foramina of Monro, foraminoplasty may lead to severe memory impairment. Therefore, cerebrospinal fluid shunting should be considered as an effective and safer treatment. CI - © BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Migliorati, Karol AU - Migliorati K AD - Department of Neurosurgery, Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. FAU - Muratori, Andrea AU - Muratori A AD - Department of Neurosurgery, Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. FAU - Fontanella, Marco Maria AU - Fontanella MM AD - Department of Neurosurgery, Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. FAU - Panciani, Pier Paolo AU - Panciani PP AD - Department of Neurosurgery, Spedali Civili University Hospital of Brescia, Brecia, Italy. LA - eng PT - Case Reports PT - Journal Article DEP - 20181025 PL - England TA - BMJ Case Rep JT - BMJ case reports JID - 101526291 SB - IM MH - Female MH - Headache Disorders/etiology MH - Humans MH - Hydrocephalus/*etiology/surgery MH - Middle Aged MH - Neuroendoscopy/*methods MH - Patient Safety MH - Spinal Stenosis/*surgery MH - Treatment Outcome MH - Urinary Incontinence/etiology MH - Ventriculoperitoneal Shunt/*methods MH - Ventriculostomy/*methods PMC - PMC6202962 OTO - NOTNLM OT - hydrocephalus OT - memory disorders OT - neuroimaging OT - neurosurgery COIS- Competing interests: None declared. EDAT- 2018/10/28 06:00 MHDA- 2019/02/08 06:00 PMCR- 2020/10/25 CRDT- 2018/10/28 06:00 PHST- 2018/10/28 06:00 [entrez] PHST- 2018/10/28 06:00 [pubmed] PHST- 2019/02/08 06:00 [medline] PHST- 2020/10/25 00:00 [pmc-release] AID - bcr-2018-226332 [pii] AID - 10.1136/bcr-2018-226332 [doi] PST - epublish SO - BMJ Case Rep. 2018 Oct 25;2018:bcr2018226332. doi: 10.1136/bcr-2018-226332. PMID- 18651755 OWN - NLM STAT- MEDLINE DCOM- 20081009 LR - 20131121 IS - 1520-6882 (Electronic) IS - 0003-2700 (Linking) VI - 80 IP - 16 DP - 2008 Aug 15 TI - Dual fluorescence sensor for trace oxygen and temperature with unmatched range and sensitivity. PG - 6449-57 LID - 10.1021/ac801034p [doi] AB - An optical dual sensor for oxygen and temperature is presented that is highly oxygen sensitive and covers a broad temperature range. Dual sensing is based on luminescence lifetime measurements. The novel sensor contains two luminescent compounds incorporated into polymer films. The temperature-sensitive dye (ruthenium tris-1,10-phenanthroline) has a highly temperature-dependent luminescence and is incorporated in poly(acrylonitrile) to avoid cross-sensitivity to oxygen. Fullerene C70 was used as the oxygen-sensitive probe owing to its strong thermally activated delayed fluorescence at elevated temperatures that is extremely oxygen sensitive. The cross-sensitivity of C70 to temperature is accounted for by means of the temperature sensor. C70 is incorporated into a highly oxygen-permeable polymer, either ethyl cellulose or organosilica. The two luminescent probes have different emission spectra and decay times, and their emissions can be discriminated using both parameters. Spatially resolved sensing is achieved by means of fluorescence lifetime imaging. The response times of the sensor to oxygen are short. The dual sensor exhibits a temperature operation range between at least 0 and 120 degrees C, and detection limits for oxygen in the ppbv range, operating for oxygen concentrations up to at least 50 ppmv. These ranges outperform all dual oxygen and temperature sensors reported so far. The dual sensor presented in this study is especially appropriate for measurements under extreme conditions such as high temperatures and ultralow oxygen levels. This dual sensor is a key step forward in a number of scientifically or commercially important applications including food packaging, for monitoring of hyperthermophilic microorganisms, in space technology, and safety and security applications in terms of detection of oxygen leaks. FAU - Baleizão, Carlos AU - Baleizão C AD - Centro de Química-Física Molecular, Instituto Superior Técnico, Universidade Técnica de Lisboa, P-1049-001 Lisboa, Portugal. carlos.baleizao@ist.utl.pt FAU - Nagl, Stefan AU - Nagl S FAU - Schäferling, Michael AU - Schäferling M FAU - Berberan-Santos, Mário N AU - Berberan-Santos MN FAU - Wolfbeis, Otto S AU - Wolfbeis OS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080724 PL - United States TA - Anal Chem JT - Analytical chemistry JID - 0370536 RN - 0 (Fluorescent Dyes) RN - 0 (Fullerenes) RN - 0 (Phenanthrolines) RN - 0 (Polymers) RN - 115383-22-7 (fullerene C70) RN - 7UI0TKC3U5 (Ruthenium) RN - S88TT14065 (Oxygen) SB - IM MH - *Biosensing Techniques MH - Calibration MH - Fluorescent Dyes/chemistry MH - Fullerenes/chemistry MH - *Luminescent Measurements MH - Optics and Photonics/*instrumentation MH - Oxygen/*chemistry MH - Phenanthrolines/chemistry MH - Polymers/*chemistry MH - Ruthenium/chemistry MH - Sensitivity and Specificity MH - Temperature EDAT- 2008/07/25 09:00 MHDA- 2008/10/10 09:00 CRDT- 2008/07/25 09:00 PHST- 2008/07/25 09:00 [pubmed] PHST- 2008/10/10 09:00 [medline] PHST- 2008/07/25 09:00 [entrez] AID - 10.1021/ac801034p [doi] PST - ppublish SO - Anal Chem. 2008 Aug 15;80(16):6449-57. doi: 10.1021/ac801034p. Epub 2008 Jul 24. PMID- 28432916 OWN - NLM STAT- MEDLINE DCOM- 20180820 LR - 20180820 IS - 1873-3557 (Electronic) IS - 1386-1425 (Linking) VI - 183 DP - 2017 Aug 5 TI - Colorimetric method for the detection of melamine using in-situ formed silver nanoparticles via tannic acid. PG - 17-22 LID - S1386-1425(17)30289-5 [pii] LID - 10.1016/j.saa.2017.04.021 [doi] AB - Melamine toxicity has recently attracted worldwide attention as it causes renal failure and the death of humans and animals. Therefore, developing a simple, fast and sensitive method for the routine detection of melamine is the need of the hour. Herein, we have developed a selective colorimetric method for the detection of melamine in milk samples based upon in-situ formation of silver nanoparticles (AgNPs) via tannic acid. The AgNPs thus formed were characterized by UV-Visible spectrophotometer, transmission electron microscope (TEM), zetasizer and dynamic light scattering (DLS). The AgNPs were used to detect melamine under in vitro condition and in raw milk spiked with melamine. Under optimal conditions, melamine could be selectively detected in vitro within the concentration range of 0.05-1.4μM with a limit of detection (LOD) of 0.01μM, which is lower than the strictest melamine safety requirement of 1ppm. In spiked raw milk, the recovery percentage range was 99.5-106.5% for liquid milk and 98.5-105.5% for powdered milk. The present method shows extreme selectivity with no significant interference with other substances like urea, glucose, glycine, ascorbic acid etc. This assay method does not utilize organic cosolvents, enzymatic reactions, light sensitive dye molecules and sophisticated instrumentation, thereby overcoming some of the limitations of the other conventional methods. CI - Copyright © 2017 Elsevier B.V. All rights reserved. FAU - Alam, Md Fazle AU - Alam MF AD - Enzymology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. FAU - Laskar, Amaj Ahmed AU - Laskar AA AD - Enzymology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. FAU - Ahmed, Shahbaz AU - Ahmed S AD - Enzymology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. FAU - Shaida, Mohd Azfar AU - Shaida MA AD - Department of Chemistry, Indian Institute of Technology, Roorkee 247667, India. FAU - Younus, Hina AU - Younus H AD - Enzymology Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address: hinayounus@rediffmail.com. LA - eng PT - Journal Article DEP - 20170417 PL - England TA - Spectrochim Acta A Mol Biomol Spectrosc JT - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JID - 9602533 RN - 0 (Tannins) RN - 0 (Triazines) RN - 3M4G523W1G (Silver) RN - N3GP2YSD88 (melamine) SB - IM MH - Animals MH - Colorimetry/*methods MH - Food Contamination/analysis MH - Limit of Detection MH - Metal Nanoparticles/*chemistry MH - Milk/chemistry MH - Silver/*chemistry MH - Tannins/*chemistry MH - Triazines/*analysis OTO - NOTNLM OT - Melamine detection OT - Silver nanoparticles OT - Tannic acid EDAT- 2017/04/23 06:00 MHDA- 2018/08/21 06:00 CRDT- 2017/04/23 06:00 PHST- 2016/08/02 00:00 [received] PHST- 2017/03/15 00:00 [revised] PHST- 2017/04/16 00:00 [accepted] PHST- 2017/04/23 06:00 [pubmed] PHST- 2018/08/21 06:00 [medline] PHST- 2017/04/23 06:00 [entrez] AID - S1386-1425(17)30289-5 [pii] AID - 10.1016/j.saa.2017.04.021 [doi] PST - ppublish SO - Spectrochim Acta A Mol Biomol Spectrosc. 2017 Aug 5;183:17-22. doi: 10.1016/j.saa.2017.04.021. Epub 2017 Apr 17. PMID- 26073060 OWN - NLM STAT- MEDLINE DCOM- 20151103 LR - 20240615 IS - 1532-6535 (Electronic) IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 98 IP - 3 DP - 2015 Sep TI - Selecting the proper pediatric dose: It is more than size that matters. PG - 238-40 LID - 10.1002/cpt.168 [doi] AB - Appropriate pediatric dose selection remains one of the most vexing clinical problems faced by healthcare professionals who are charged to provide medical care to infants and children. While body size does reflect the ontogeny of processes that govern drug disposition, there are extremes of disease that perturb the expected relationships. CI - © 2015 ASCPT. FAU - Kearns, G L AU - Kearns GL AD - Arkansas Children's Hospital Research Institute and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. LA - eng GR - HHSN275201000003C/HD/NICHD NIH HHS/United States GR - HHSN275201000003I/HD/NICHD NIH HHS/United States GR - T32 HD069038/HD/NICHD NIH HHS/United States GR - 1T32HD069038-01/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20150716 PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Pharmaceutical Preparations) SB - IM MH - Age Factors MH - *Body Size MH - Child MH - Child, Preschool MH - Comorbidity MH - Dose-Response Relationship, Drug MH - *Drug Dosage Calculations MH - Drug-Related Side Effects and Adverse Reactions/etiology/prevention & control MH - Humans MH - Infant MH - Infant, Newborn MH - Patient Safety MH - Pharmaceutical Preparations/*administration & dosage/metabolism MH - Pharmacogenetics MH - Pharmacokinetics MH - Risk Assessment MH - Risk Factors PMC - PMC4543563 MID - NIHMS701814 EDAT- 2015/06/16 06:00 MHDA- 2015/11/04 06:00 PMCR- 2016/09/01 CRDT- 2015/06/16 06:00 PHST- 2015/06/16 06:00 [entrez] PHST- 2015/06/16 06:00 [pubmed] PHST- 2015/11/04 06:00 [medline] PHST- 2016/09/01 00:00 [pmc-release] AID - 10.1002/cpt.168 [doi] PST - ppublish SO - Clin Pharmacol Ther. 2015 Sep;98(3):238-40. doi: 10.1002/cpt.168. Epub 2015 Jul 16. PMID- 25558742 OWN - NLM STAT- MEDLINE DCOM- 20150316 LR - 20150106 IS - 1592-7830 (Print) IS - 1592-7830 (Linking) VI - 36 IP - 4 DP - 2014 Oct-Dec TI - [Risk factors in police activities: operational criticism in surveillance programs]. PG - 397-9 AB - The planning of specific health surveillance programs for police officers is extremely complex due to difficulty in predictability and variety of occupational hazards. Even in the case of conventional occupational risk factors clearly identified by current regulations, particular working conditions may require specific assessment to effectively identify and quantify the risk of occupational exposure. An extensive program of health surveillance, aimed at promoting overall health and effectiveness of the operators, would be really desirable, in order to help better address a number of risks that cannot be easily predicted. The progressive increase in the average age of the working population and the increasing prevalence of chronic degenerative diseases, may also suggest the need for health surveillance procedures designed to verify continued unqualified suitability to police service, providing for the identification of diversified suitability profiles in relation to age and state of health: accordingly, in regard to our field of interest, there is a close link between medico-legal eligibility and occupational medicine. FAU - Ciprani, Fabrizio AU - Ciprani F AD - Ministero dell'Interno - Dipartimento della Pubblica Sicurezza, Direzione Centrale Sanità. FAU - Moroni, Maria AU - Moroni M FAU - Conte, Giovanni AU - Conte G LA - spa PT - English Abstract PT - Journal Article PT - Review TT - Fattori di rischio nell'attività di Polizia: criticità operative nei protocolli di sorveglianza. PL - Italy TA - G Ital Med Lav Ergon JT - Giornale italiano di medicina del lavoro ed ergonomia JID - 9712708 RN - 0 (Hazardous Substances) SB - IM MH - Chronic Disease MH - Hazardous Substances/adverse effects MH - Humans MH - Italy MH - *Law Enforcement MH - Noise/adverse effects MH - Occupational Diseases/*epidemiology/prevention & control MH - Occupational Exposure MH - *Police/legislation & jurisprudence/statistics & numerical data MH - Population Dynamics MH - *Population Surveillance MH - Risk Assessment/legislation & jurisprudence MH - Risk Factors MH - Safety Management/*organization & administration MH - Stress, Psychological/epidemiology MH - Work Capacity Evaluation EDAT- 2015/01/07 06:00 MHDA- 2015/03/17 06:00 CRDT- 2015/01/07 06:00 PHST- 2015/01/07 06:00 [entrez] PHST- 2015/01/07 06:00 [pubmed] PHST- 2015/03/17 06:00 [medline] PST - ppublish SO - G Ital Med Lav Ergon. 2014 Oct-Dec;36(4):397-9. PMID- 28025766 OWN - NLM STAT- MEDLINE DCOM- 20180928 LR - 20181113 IS - 1970-9366 (Electronic) IS - 1828-0447 (Linking) VI - 13 IP - 1 DP - 2018 Jan TI - Safety of cardioversion in atrial fibrillation lasting less than 48 h without post-procedural anticoagulation in patients at low cardioembolic risk. PG - 87-93 LID - 10.1007/s11739-016-1589-1 [doi] AB - Currently, there is no unified consensus on short-term anticoagulation after cardioversion of atrial fibrillation lasting less than 48 h in low-cardioembolic-risk patients. The aim of this study is to evaluate the rate of transient ischemic attacks, stroke and death in this subset of patients after cardioversion without post-procedural anticoagulation. In a prospective observational study, patients with recent-onset AF undergoing cardioversion attempts in the Emergency Department were evaluated over the past 3 years. Inclusion criteria were conversion to sinus rhythm, low thromboembolic risk defined by a CHA2DS2VASc score of 0-1 points for males (0-2 points for females aged over 65 years), and hospital discharge without anticoagulant treatment. Patients with severe valvular heart disease, underlying systemic causes of AF, and those discharged with anticoagulant therapy were excluded. The main outcomes measured were TIA, stroke and death at thirty days' follow-up after discharge. During the study period, 218 successful cardioversions, obtained both electrically and pharmacologically, were performed on 157 patients. One hundred and eleven patients were males (71%), the mean age was 55.2 years (±standard deviation 10.7), 99 patients (63%) reported a CHA2DS2VASc score of 0, and the remaining 58 (37%) had a risk profile of 1 point. Of these, latter 8 were females (5%) older than 65 years (risk score 2 points). At the thirty days outcome, none of the 150 enrolled patients who completed a follow-up visit has reported TIA or stroke, nor died, in the overall 211 successful cardioversions evaluated. In our study, the rate of thromboembolic events after cardioversion of recent-onset AF of less than 48 h duration, in patients with a 0-1 CHA2DS2VASc risk profile (females 0-2), appeared to be extremely low even in absence of post-procedural anticoagulation. These findings seem to confirm data from previous studies, and suggest that routine post-procedural short-term anticoagulation may be considered as an overtreatment in this very low-risk subset of patients. FAU - Tampieri, Andrea AU - Tampieri A AD - Emergency Department, S.Maria della Scaletta Hospital, via Montericco 4, Imola, 40026, Bologna, Italy. andrea.tampieri@libero.it. FAU - Cipriano, Valentina AU - Cipriano V AD - Emergency Department, S.Maria della Scaletta Hospital, via Montericco 4, Imola, 40026, Bologna, Italy. FAU - Mucci, Fabrizio AU - Mucci F AD - Emergency Department, S.Maria della Scaletta Hospital, via Montericco 4, Imola, 40026, Bologna, Italy. FAU - Rusconi, Anna Maria AU - Rusconi AM AD - Fondazione IRCCS Cà Granda, Maggiore Policlinico Hospital, Milan, Italy. FAU - Lenzi, Tiziano AU - Lenzi T AD - Emergency Department, S.Maria della Scaletta Hospital, via Montericco 4, Imola, 40026, Bologna, Italy. FAU - Cenni, Patrizia AU - Cenni P AD - Emergency Department, S.Maria della Scaletta Hospital, via Montericco 4, Imola, 40026, Bologna, Italy. LA - eng PT - Journal Article DEP - 20161226 PL - Italy TA - Intern Emerg Med JT - Internal and emergency medicine JID - 101263418 RN - 0 (Anticoagulants) SB - IM MH - Adult MH - Aged MH - Anticoagulants/therapeutic use MH - Atrial Fibrillation/epidemiology/*therapy MH - Electric Countershock/methods/*standards MH - Female MH - Hospital Mortality/trends MH - Humans MH - Ischemic Attack, Transient/epidemiology MH - Male MH - Middle Aged MH - Patient Safety/*standards MH - Risk Assessment MH - Stroke/epidemiology MH - Thromboembolism/drug therapy/*prevention & control MH - Thrombolytic Therapy/adverse effects/*standards/statistics & numerical data OTO - NOTNLM OT - Atrial fibrillation OT - Cardioembolic risk OT - Cardioversion OT - Short-term anticoagulation OT - Stroke EDAT- 2016/12/28 06:00 MHDA- 2018/10/03 06:00 CRDT- 2016/12/28 06:00 PHST- 2016/09/01 00:00 [received] PHST- 2016/12/01 00:00 [accepted] PHST- 2016/12/28 06:00 [pubmed] PHST- 2018/10/03 06:00 [medline] PHST- 2016/12/28 06:00 [entrez] AID - 10.1007/s11739-016-1589-1 [pii] AID - 10.1007/s11739-016-1589-1 [doi] PST - ppublish SO - Intern Emerg Med. 2018 Jan;13(1):87-93. doi: 10.1007/s11739-016-1589-1. Epub 2016 Dec 26. PMID- 21386114 OWN - NLM STAT- MEDLINE DCOM- 20111223 LR - 20171116 IS - 1759-9873 (Electronic) IS - 0964-5284 (Linking) VI - 29 IP - 2 DP - 2011 Jun TI - Electroacupuncture on a patient with pacemaker: a case report. PG - 152-3 LID - 10.1136/aim.2010.003863 [doi] AB - Electroacupuncture (EA) is commonly used for pain relief, with good results even in persistent chronic pain. However, published reports suggest that EA should not be used in patients who have pacemaker, since there is a theoretical risk of malfunction of the pacemaker. The case is described of a 50-year-old female patient, who has had severe low back pain resistant both to conventional and unconventional treatment methods. The only treatment that seemed to have some positive effect, but of extremely short duration, was acupuncture. Her condition deteriorated considerably, and after due consideration she was treated with EA. Even after the first EA treatment, the patient's condition improved. Since then, she has received many EA courses during the past 2 years without any complications or side effects. The results of this case study suggest that EA might be a safe alternative for patients with a pacemaker, confirming the current recommendations on use. Every patient should be considered with care, individually. FAU - Vasilakos, Dimitrios G AU - Vasilakos DG AD - Anesthesiology and ICU Department, AHEPA University Hospital, Thessaloniki, Greece. FAU - Fyntanidou, Barbara P AU - Fyntanidou BP LA - eng PT - Case Reports PT - Journal Article DEP - 20110308 PL - England TA - Acupunct Med JT - Acupuncture in medicine : journal of the British Medical Acupuncture Society JID - 9304117 SB - IM MH - Contraindications MH - *Electric Stimulation MH - *Electroacupuncture MH - *Equipment Failure MH - Female MH - Humans MH - Low Back Pain/*therapy MH - Middle Aged MH - *Pacemaker, Artificial MH - Safety EDAT- 2011/03/10 06:00 MHDA- 2011/12/24 06:00 CRDT- 2011/03/10 06:00 PHST- 2011/03/10 06:00 [entrez] PHST- 2011/03/10 06:00 [pubmed] PHST- 2011/12/24 06:00 [medline] AID - aim.2010.003863 [pii] AID - 10.1136/aim.2010.003863 [doi] PST - ppublish SO - Acupunct Med. 2011 Jun;29(2):152-3. doi: 10.1136/aim.2010.003863. Epub 2011 Mar 8. PMID- 25980228 OWN - NLM STAT- MEDLINE DCOM- 20150602 LR - 20150518 IS - 0031-2991 (Print) IS - 0031-2991 (Linking) IP - 4 DP - 2014 Oct-Dec TI - [Peculiarity of autonomic functions regulation remodeling in human adaptation to extreme conditions in labor activities]. PG - 59-65 AB - In modem society, professional activity in conditions of extreme factors occupies a growing place. Of particular note is the work related to night shifts involving up to 20% of the population. In some cases, this work may lead to a breach of the adaptation processes of the body and increase the risk of diseases. The necessity to search criteria of dysregulation changes in the human body during adaptation to extreme conditions in labor activities is the actual problem from the standpoint of preventive health care of the working population health and providing safety in professional activities conditions. In our work, we attempted to identify early signs of autonomic function's dysregulation by analyzing the heart rhythm variability in locomotive operators and doctors on duty. It was revealed that these groups of people with different levels of intensity of professional activities may be the model for observation of the stages of dysregulation process. It is also shown that the earliest markers of autonomic regulation remodeling are indicators of the spectral analysis of heart rhythm variability, reflecting the activity of the total power regulation (TP) and parasympathetic part (HF). FAU - Merkulov, Y A AU - Merkulov YA FAU - Pyatkov, A A AU - Pyatkov AA FAU - Merkulova, D M AU - Merkulova DM LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Patol Fiziol Eksp Ter JT - Patologicheskaia fiziologiia i eksperimental'naia terapiia JID - 0376421 SB - IM MH - Adaptation, Physiological/*physiology MH - Adult MH - Autonomic Nervous System/*physiopathology MH - Burnout, Professional/*physiopathology MH - Electrocardiography MH - Heart Rate/physiology MH - Humans MH - Male MH - Middle Aged MH - Occupational Health MH - Parasympathetic Nervous System/physiology MH - *Workload EDAT- 2015/05/20 06:00 MHDA- 2015/06/03 06:00 CRDT- 2015/05/19 06:00 PHST- 2015/05/19 06:00 [entrez] PHST- 2015/05/20 06:00 [pubmed] PHST- 2015/06/03 06:00 [medline] PST - ppublish SO - Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):59-65. PMID- 10443044 OWN - NLM STAT- MEDLINE DCOM- 19990908 LR - 20190910 IS - 1784-3286 (Print) IS - 1784-3286 (Linking) VI - 54 IP - 3 DP - 1999 Jun TI - Severe/extreme obesity: a medical disease requiring a surgical treatment? PG - 154-61 AB - Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with comorbidities or extreme obesity (BMI > or = 40 kg/m2). Before accepting bariatric surgery as alternative treatment, the four following prerequisites should be met: 1. the medical condition is serious enough; 2. it can not be treated satisfactorily with classical means; 3. the surgical treatment is effective in improving the clinical situation; and 4. bariatric surgery is safe enough, so that the benefits clearly outweigh the risks. On the basis of the literature and our own experience, it appears that gastric reduction surgery may be considered as a valuable alternative for treating severe/extreme obesity, despite the possible occurrence of perioperative and, more frequently, late complications, provided that it is performed by an experienced and multidisciplinary team in well-selected patients. FAU - Scheen, A J AU - Scheen AJ AD - Service de Diabétologie, Nutrition et Maladies métaboliques, CHU Sart Tilman, Liège, Belgique. Andre.Scheen@chu.ulg.ac.be FAU - Luyckx, F H AU - Luyckx FH FAU - Desaive, C AU - Desaive C FAU - Lefèbvre, P J AU - Lefèbvre PJ LA - eng PT - Journal Article PT - Review PL - England TA - Acta Clin Belg JT - Acta clinica Belgica JID - 0370306 RN - 0 (Anti-Obesity Agents) SB - IM CIN - Acta Clin Belg. 1999 Jun;54(3):141-6. doi: 10.1080/17843286.1999.11754219. PMID: 10443041 MH - Anti-Obesity Agents/therapeutic use MH - Body Mass Index MH - Diet, Reducing MH - Gastric Bypass/adverse effects/methods MH - Gastroplasty/adverse effects/methods MH - Humans MH - Intraoperative Complications/prevention & control MH - Obesity/complications/*surgery MH - Obesity, Morbid/complications/*surgery MH - Patient Selection MH - Postoperative Complications/prevention & control MH - Risk Assessment MH - Safety MH - Stomach/surgery MH - Treatment Outcome RF - 44 EDAT- 1999/08/12 00:00 MHDA- 1999/08/12 00:01 CRDT- 1999/08/12 00:00 PHST- 1999/08/12 00:00 [pubmed] PHST- 1999/08/12 00:01 [medline] PHST- 1999/08/12 00:00 [entrez] AID - 10.1080/17843286.1999.11754222 [doi] PST - ppublish SO - Acta Clin Belg. 1999 Jun;54(3):154-61. doi: 10.1080/17843286.1999.11754222. PMID- 22785399 OWN - NLM STAT- MEDLINE DCOM- 20130423 LR - 20220321 IS - 1875-8908 (Electronic) IS - 1387-2877 (Linking) VI - 32 IP - 2 DP - 2012 TI - Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials. PG - 273-6 LID - 10.3233/JAD-2012-120931 [doi] AB - Microglia is thought to be important in Alzheimer's disease. Therefore, our aim was to investigate the usefulness of the microglial marker chitotriosidase in clinical trials. Chitotriosidase was analyzed in cerebrospinal fluid from Alzheimer's disease patients on acetylcholine esterase inhibitors (AChEI) and in cerebrospinal fluid from multiple sclerosis patients before and after natalizumab treatment. Chitotriosidase activity was extremely stable during treatment with the non-inflammatory drug AChEI. However, the immunomodulatory treatment with natalizumab led to lower chitotriosidase activity. Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ. FAU - Olsson, Bob AU - Olsson B AD - Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden. bob.olsson@medic.gu.se FAU - Malmeström, Clas AU - Malmeström C FAU - Basun, Hans AU - Basun H FAU - Annas, Peter AU - Annas P FAU - Höglund, Kina AU - Höglund K FAU - Lannfelt, Lars AU - Lannfelt L FAU - Andreasen, Niels AU - Andreasen N FAU - Zetterberg, Henrik AU - Zetterberg H FAU - Blennow, Kaj AU - Blennow K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Alzheimers Dis JT - Journal of Alzheimer's disease : JAD JID - 9814863 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 0 (Biomarkers) RN - 0 (Natalizumab) RN - EC 3.2.1.- (Hexosaminidases) RN - EC 3.2.1.- (chitotriosidase) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Alzheimer Disease/*cerebrospinal fluid MH - Antibodies, Monoclonal, Humanized/therapeutic use MH - Biomarkers/cerebrospinal fluid MH - Clinical Trials as Topic MH - Female MH - Hexosaminidases/*cerebrospinal fluid MH - Humans MH - Male MH - Microglia/*enzymology MH - Middle Aged MH - Multiple Sclerosis/cerebrospinal fluid/drug therapy MH - Natalizumab EDAT- 2012/07/13 06:00 MHDA- 2013/04/24 06:00 CRDT- 2012/07/13 06:00 PHST- 2012/07/13 06:00 [entrez] PHST- 2012/07/13 06:00 [pubmed] PHST- 2013/04/24 06:00 [medline] AID - D146188187275T81 [pii] AID - 10.3233/JAD-2012-120931 [doi] PST - ppublish SO - J Alzheimers Dis. 2012;32(2):273-6. doi: 10.3233/JAD-2012-120931. PMID- 24593227 OWN - NLM STAT- MEDLINE DCOM- 20151019 LR - 20151119 IS - 1539-6924 (Electronic) IS - 0272-4332 (Linking) VI - 34 IP - 8 DP - 2014 Aug TI - You have been framed! How antecedents of information need mediate the effects of risk communication messages. PG - 1506-20 LID - 10.1111/risa.12181 [doi] AB - This study investigates the processes that mediate the effects of framing flood risks on people's information needs. Insight into the effects of risk frames is important for developing balanced risk communication that explains both risks and benefits of living near water. The research was inspired by the risk information seeking and processing model and related models. In a web-based survey, respondents (n = 1,457) were randomly assigned to one of three communication frames or a control frame (experimental conditions). Each frame identically explained flood risk and additionally refined the message by emphasizing climate change, the quality of flood risk management, or the amenities of living near water. We tested the extent to which risk perceptions, trust, and affective responses mediate the framing effects on information need. As expected, the frames on average resulted in higher information need than the control frame. Attempts to lower fear appeal by stressing safety or amenities instead of climate change were marginally successful, a phenomenon that is known as a "negativity bias." Framing effects were mediated by negative attributes (risk perception and negative affect) but not by positive attributes (trust and positive affect). This finding calls for theoretical refinement. Practically, communication messages will be more effective when they stimulate risk perceptions and evoke negative affect. However, arousal of fear may have unwanted side effects. For instance, fear arousal could lead to lower levels of trust in risk management among citizens. Regular monitoring of citizens' attitudes is important to prevent extreme levels of distrust or cynicism. CI - © 2014 Society for Risk Analysis. FAU - Terpstra, T AU - Terpstra T AD - HKV Consultants, 8203 AC, Lelystad, the Netherlands. FAU - Zaalberg, R AU - Zaalberg R FAU - de Boer, J AU - de Boer J FAU - Botzen, W J W AU - Botzen WJ LA - eng PT - Journal Article DEP - 20140304 PL - United States TA - Risk Anal JT - Risk analysis : an official publication of the Society for Risk Analysis JID - 8109978 SB - IM MH - Affect MH - Climate Change MH - *Communication MH - Cross-Sectional Studies MH - Fear MH - Floods MH - Humans MH - Netherlands MH - Perception MH - *Risk MH - Risk Management MH - Safety Management MH - Surveys and Questionnaires MH - Trust OTO - NOTNLM OT - Affect heuristic OT - flood risk OT - framing OT - information seeking OT - mediation analysis OT - risk communication OT - risk perception OT - trust EDAT- 2014/03/07 06:00 MHDA- 2015/10/20 06:00 CRDT- 2014/03/06 06:00 PHST- 2014/03/06 06:00 [entrez] PHST- 2014/03/07 06:00 [pubmed] PHST- 2015/10/20 06:00 [medline] AID - 10.1111/risa.12181 [doi] PST - ppublish SO - Risk Anal. 2014 Aug;34(8):1506-20. doi: 10.1111/risa.12181. Epub 2014 Mar 4. PMID- 16514624 OWN - NLM STAT- MEDLINE DCOM- 20060602 LR - 20131121 IS - 0736-0266 (Print) IS - 0736-0266 (Linking) VI - 24 IP - 5 DP - 2006 May TI - High-dose gamma irradiation for soft tissue allografts: High margin of safety with biomechanical integrity. PG - 1011-8 AB - Screening and processing methods currently in place have made the risk of bacterial and viral infections from allograft tissues extremely low. However, the development of a terminal sterilization method that does not adversely affect tissue function would provide an added safety to tissues for transplantation. We assessed whether high-dose gamma irradiation could be used as an effective terminal sterilization method for allografts without impairing the preimplantation mechanical integrity of the tissues. Semitendinosus tendons were pretreated with a radioprotectant solution and then irradiated to 50 kGy under well-defined conditions that included a tight dose range and maintained low temperatures. Maximum force, strain, stress, modulus, and strain energy density for tendons irradiated to 50 kGy were compared to nonirradiated control tendons and tendons irradiated to 18 kGy by a commercial tissue bank using their existing method. The preimplantation biomechanical properties of the 50-kGy group compared favorably to the nonirradiated and 18 kGy groups. A study to evaluate the postimplantation mechanical and biological performance of grafts irradiated to 50 kGy is ongoing. Pathogen inactivation was also quantified following 50 kGy of irradiation, with > or =4.5 logs of Sindbis virus and 4.9 logs of parvovirus kill achieved. Analysis of Clostridium sordellii inactivation kinetics indicated that a 16 log10 reduction is predicted with 50 kGy of irradiation. A high dose of gamma irradiation using the described conditions can reduce infectious risks associated with soft tissue allografts while maintaining the preimplantation biomechanical performance of the tissues. CI - Copyright 2006 Orthopaedic Research Society. FAU - Grieb, Teri A AU - Grieb TA AD - Clearant, Inc., 11111 Santa Monica Boulevard, Suite 650 Los Angeles, California 90025, USA. FAU - Forng, Ren-Yo AU - Forng RY FAU - Bogdansky, Simon AU - Bogdansky S FAU - Ronholdt, Chad AU - Ronholdt C FAU - Parks, Brent AU - Parks B FAU - Drohan, William N AU - Drohan WN FAU - Burgess, Wilson H AU - Burgess WH FAU - Lin, Jack AU - Lin J LA - eng PT - Journal Article PL - United States TA - J Orthop Res JT - Journal of orthopaedic research : official publication of the Orthopaedic Research Society JID - 8404726 SB - IM MH - Adolescent MH - Adult MH - Biomechanical Phenomena MH - Clostridium sordellii/radiation effects MH - Gamma Rays/*adverse effects MH - Humans MH - Middle Aged MH - Safety MH - *Sterilization MH - Tendons/microbiology/physiology/*radiation effects/transplantation MH - Tensile Strength MH - Transplantation, Homologous EDAT- 2006/03/04 09:00 MHDA- 2006/06/03 09:00 CRDT- 2006/03/04 09:00 PHST- 2006/03/04 09:00 [pubmed] PHST- 2006/06/03 09:00 [medline] PHST- 2006/03/04 09:00 [entrez] AID - 10.1002/jor.20079 [doi] PST - ppublish SO - J Orthop Res. 2006 May;24(5):1011-8. doi: 10.1002/jor.20079. PMID- 22607254 OWN - NLM STAT- MEDLINE DCOM- 20120827 LR - 20181201 IS - 1538-957X (Electronic) IS - 1538-9588 (Linking) VI - 13 IP - 3 DP - 2012 TI - Nonconformities in real-world fatal crashes--electronic stability control and seat belt reminders. PG - 308-14 LID - 10.1080/15389588.2011.653842 [doi] AB - OBJECTIVE: Many new safety systems are entering the market. Vision Zero is a safety strategy aiming at the elimination of fatalities and impairing injuries by the use of a holistic model for safe traffic to develop a safe system. The aim of this article is to analyze fatalities in modern cars with respect to the Vision Zero model with special respect to electronic stability control (ESC) systems and modern seat belt reminders (SBRs). The model is used to identify and understand cases where cars with ESC systems lost control and where occupants were unbelted in a seat with seat belt reminders under normal driving conditions. METHODS: The model for safe traffic was used to analyze in-depth studies of fatal crashes with respect to seat belt use and loss of control. Vehicles from 2003 and later in crashes from January 2004 to mid-2010 were analyzed. The data were analyzed case by case. Cars that were equipped with ESC systems and lost control and occupants not using the seat belt in a seat with a seat belt reminder were considered as nonconformities. A total of 138 fatal crashes involving 152 fatally injured occupants were analyzed. RESULTS: Cars with ESC systems had fewer loss-of-control-relevant cases than cars without ESC systems. Thirteen percent of the ESC-equipped vehicles had loss-of-control-relevant crashes and 36 percent of the cars without ESC systems had loss-of-control-relevant crashes. The analysis indicates that only one car of the 9 equipped with ESC that lost control did it on a road surface with relevant friction when driving within the speed restriction of the road. In seats with seat belt reminders that are in accordance with the European New Car Assessment Programme's (Euro NCAP) protocol, 93 percent of the occupants were using a seat belt. In seats without reminders this number was 74 percent. CONCLUSIONS: This study shows that ESC systems result in a very significant reduction in fatal crashes, especially under normal driving conditions. Under extreme driving conditions such as speeding or extremely low friction (snow or on the side of the road), ESC systems can fail in keeping the car under control. Seat belt reminders result in higher seat belt use rates but the level of unbelted occupants is higher than roadside studies have indicated. The holistic Vision Zero approach helped in the analysis by identifying nonconformities and putting these into the safe systems perspective. FAU - Lie, Anders AU - Lie A AD - Division of Insurance Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. anders.lie@trafikverket.se LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Traffic Inj Prev JT - Traffic injury prevention JID - 101144385 SB - IM MH - Accidents, Traffic/*mortality/prevention & control MH - Automobile Driving/*psychology MH - Automobiles/*statistics & numerical data MH - Humans MH - Protective Devices/*statistics & numerical data MH - Reminder Systems/*statistics & numerical data MH - Safety Management/*methods MH - Seat Belts/statistics & numerical data MH - Sweden/epidemiology EDAT- 2012/05/23 06:00 MHDA- 2012/08/28 06:00 CRDT- 2012/05/22 06:00 PHST- 2012/05/22 06:00 [entrez] PHST- 2012/05/23 06:00 [pubmed] PHST- 2012/08/28 06:00 [medline] AID - 10.1080/15389588.2011.653842 [doi] PST - ppublish SO - Traffic Inj Prev. 2012;13(3):308-14. doi: 10.1080/15389588.2011.653842. PMID- 12074420 OWN - NLM STAT- MEDLINE DCOM- 20021220 LR - 20190916 IS - 0265-0215 (Print) IS - 0265-0215 (Linking) VI - 19 IP - 4 DP - 2002 Apr TI - Stability of a sufentanil-ropivacaine mixture in a glass and a PVC reservoir. PG - 295-7 AB - BACKGROUND AND OBJECTIVE: Drug mixtures containing sufentanil may be unstable owing to absorption into the drug reservoirs of patient-controlled epidural analgesia systems that contain polyvinylchloride. The stability of sufentanil in a mixture of ropivacaine 0.2% in a 750 mL reservoir was therefore investigated. METHODS: During simulated epidural infusions of 5 mLh(-1) at 25 degrees C, sufentanil concentrations were measured for 96 h. Samples were taken from the reservoir and from the end of the epidural catheter under the following conditions: into glass or polyvinylchloride reservoirs containing ropivacaine 0.2% with sufentanil 1, 0.75 or 0.5 microg mL(-1); and into polyvinylchloride reservoirs with ropivacaine 0.2% and sufentanil 1 microg mL(-1) which were stored for 4 weeks at 8 degrees C. RESULTS: The different solutions remained stable over the observation period of 96 h. Using the same solutions, independent samples' ANOVA showed no difference in the sufentanil concentrations between the glass and polyvinylchloride reservoirs, or between the polyvinylchloride reservoirs when stored for 4 weeks. Correlations between the concentrations at the different measurement times were extremely high for the reservoir (r(min) = 0.98, r(max) = 1.00) and the catheter end (rmin = 0.86, r(max) = 1.00). CONCLUSIONS: Sufentanil citrate at 0.5-1.0 microg mL(-1) in an admixture of ropivacaine 0.29 for 5 days, which is the usual period for postoperative epidural analgesia, remains stable in a polyvinylchloride reservoir. There is no change in the drug concentration even if the reservoir is stored for 4 weeks at 8 degrees C. FAU - Brodner, G AU - Brodner G AD - Universitätsklinikum Münster, Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Germany. FAU - Ermert, T AU - Ermert T FAU - Van Aken, H AU - Van Aken H FAU - Westphal, M AU - Westphal M FAU - Marcus, M A E AU - Marcus MA FAU - Gogarten, W AU - Gogarten W FAU - Goeters, C AU - Goeters C FAU - Bürkle, H AU - Bürkle H LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Eur J Anaesthesiol JT - European journal of anaesthesiology JID - 8411711 RN - 0 (Amides) RN - 0 (Anesthetics, Combined) RN - 0 (Anesthetics, Intravenous) RN - 0 (Anesthetics, Local) RN - 0 (Drug Combinations) RN - 7IO5LYA57N (Ropivacaine) RN - 9002-86-2 (Polyvinyl Chloride) RN - AFE2YW0IIZ (Sufentanil) SB - IM MH - Amides/*chemistry MH - Analgesia, Patient-Controlled/instrumentation MH - Anesthetics, Combined MH - Anesthetics, Intravenous/*chemistry MH - Anesthetics, Local/*chemistry MH - Drug Combinations MH - Drug Stability MH - Humans MH - Pain, Postoperative/drug therapy MH - Polyvinyl Chloride MH - Ropivacaine MH - Safety MH - Sufentanil/*chemistry EDAT- 2002/06/21 10:00 MHDA- 2002/12/21 04:00 CRDT- 2002/06/21 10:00 PHST- 2002/06/21 10:00 [pubmed] PHST- 2002/12/21 04:00 [medline] PHST- 2002/06/21 10:00 [entrez] AID - 10.1017/s0265021502000479 [doi] PST - ppublish SO - Eur J Anaesthesiol. 2002 Apr;19(4):295-7. doi: 10.1017/s0265021502000479. PMID- 11699892 OWN - NLM STAT- MEDLINE DCOM- 20020412 LR - 20121115 IS - 1464-8431 (Print) IS - 1464-8431 (Linking) VI - 3 IP - 5 DP - 2001 Oct TI - Lentiviral vectors for the treatment of neurodegenerative diseases. PG - 476-81 AB - A number of potential gene therapy applications in the adult nervous system include neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. During the last five years, lentiviral vectors have developed into extremely efficient gene transfer vehicles to the nervous system, revealing a wide range of possibilities for the treatment or such disorders. This review describes the most important and recent advances in the development of lentiviral vectors as well as the demonstration of proof-of-principle in animal models of human neurodegenerative diseases. FAU - Martin-Rendon, E AU - Martin-Rendon E AD - Oxford BioMedica, UK. FAU - Azzouz, M AU - Azzouz M FAU - Mazarakis, N D AU - Mazarakis ND LA - eng PT - Journal Article PT - Review PL - England TA - Curr Opin Mol Ther JT - Current opinion in molecular therapeutics JID - 100891485 SB - IM MH - Alzheimer Disease/therapy MH - Amyotrophic Lateral Sclerosis/therapy MH - Animals MH - Genetic Therapy/adverse effects/*methods/trends MH - *Genetic Vectors MH - Humans MH - Huntington Disease/therapy MH - Lentivirus/*genetics MH - Nervous System/metabolism MH - Neurodegenerative Diseases/*therapy MH - Parkinsonian Disorders/therapy MH - Safety RF - 55 EDAT- 2001/11/09 10:00 MHDA- 2002/04/16 10:01 CRDT- 2001/11/09 10:00 PHST- 2001/11/09 10:00 [pubmed] PHST- 2002/04/16 10:01 [medline] PHST- 2001/11/09 10:00 [entrez] PST - ppublish SO - Curr Opin Mol Ther. 2001 Oct;3(5):476-81. PMID- 6377121 OWN - NLM STAT- MEDLINE DCOM- 19840820 LR - 20181130 IS - 0026-4806 (Print) IS - 0026-4806 (Linking) VI - 75 IP - 25 DP - 1984 Jun 16 TI - [Aerospace medicine and its scientific and technological fallout in the field of general biomedicine]. PG - 1475-92 AB - A general preliminary study is made of possible "fall-out" applications from military technology--especially in certain electronics sectors--enabling such technology to be used for non-military purposes that would greatly benefit society, for example in the biomedical field. The continued and profitable exchange that is rapidly developing, not only between technology and science but also between science and technology in the specific sector of aviation medicine, in discussed in detail. The direct and indirect theoretical and practical applications of aviation medicine in medical science, practical medicine and health services are briefly outlined (apparatus for inhaling oxygen; safety and "delethalisation" methods for accidents caused by violent impact; the application of minor technologies in the fields of immunology and hygiene-prophylaxis to air transport and rescue services; the selection and medico-legal check-ups of all military and civilian flight personnel; the emergency transport of transplant organs and seriously ill patients requiring emergency transplants, etc.). Current and possible future practical applications of the vast experience acquired by space medicine had to solve complex problems relating to space flight and man's survival in space, such as: the absence of gravity (and its functional effects on the body's main system and organs), exposure to cosmic and solar radiation, conditioning and prolonged isolation in the space capsule, modifications in circadian rhythms, "space sickness", etc. Finally, the study recalls that the evolution and refinement of aerospace technology has made it possible to make use of exceptional space conditions, such as "microgravity", to conduct in-depth studies--in extreme conditions--of certain biological phenomena and to gain further knowledge of the genesis and to gain of various vital processes. Another area under study is the production--in extremely favourable conditions--of new, vaccines, enzymes and hormones, new drugs for therapy and prophylaxis and for biopharmacology, and new food sources which are of prime importance for man's future requirements. FAU - Rotondo, G AU - Rotondo G LA - ita PT - Journal Article TT - Medicina aerospaziale e sua "ricaduta" scientifica e tecnologica in campo biomedico generale. PL - Italy TA - Minerva Med JT - Minerva medica JID - 0400732 RN - 11000-17-2 (Vasopressins) RN - 4964P6T9RB (Aldosterone) RN - EC 3.4.23.15 (Renin) RN - YKH834O4BH (Epinephrine) SB - IM MH - Accidents, Aviation/prevention & control MH - *Aerospace Medicine MH - Aldosterone/metabolism MH - Altitude Sickness/prevention & control MH - Biomedical Engineering MH - Epinephrine/metabolism MH - First Aid MH - Humans MH - Renin/metabolism MH - Research MH - Stress, Physiological/prevention & control MH - Transportation of Patients MH - Vasodilation MH - Vasopressins/metabolism MH - Weightlessness OID - NASA: 84246357 EDAT- 1984/06/16 00:00 MHDA- 1984/06/16 00:01 CRDT- 1984/06/16 00:00 PHST- 1984/06/16 00:00 [pubmed] PHST- 1984/06/16 00:01 [medline] PHST- 1984/06/16 00:00 [entrez] PST - ppublish SO - Minerva Med. 1984 Jun 16;75(25):1475-92. PMID- 28607187 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20170724 LR - 20180728 IS - 1364-503X (Print) IS - 1471-2962 (Electronic) IS - 1364-503X (Linking) VI - 375 IP - 2098 DP - 2017 Jul 28 TI - Hydrogen-related challenges for the steelmaker: the search for proper testing. LID - 10.1098/rsta.2016.0408 [doi] LID - 20160408 AB - The modern steelmaker of advanced high-strength steels has always been challenged with the conflicting targets of increased strength while maintaining or improving ductility. These new steels help the transportation sector, including the automotive sector, to achieve the goals of increased passenger safety and reduced emissions. With increasing tensile strengths, certain steels exhibit an increased sensitivity towards hydrogen embrittlement (HE). The ability to characterize the material's sensitivity in an as-delivered condition has been developed and accepted (SEP1970), but the complexity of the stress states that can induce an embrittlement together with the wide range of applications for high-strength steels make the development of a standardized test for HE under in-service conditions extremely challenging. Some proposals for evaluating the material's sensitivity give an advantage to materials with a low starting ductility. Despite this, newly developed materials can have a higher original elongation with only a moderate reduction in elongation due to hydrogen. This work presents a characterization of new materials and their sensitivity towards HE.This article is part of the themed issue 'The challenges of hydrogen and metals'. CI - © 2017 The Author(s). FAU - Thiessen, R G AU - Thiessen RG AUID- ORCID: 0000-0002-6695-6326 AD - thyssenkrupp Steel Europe AG, Kaiser-Wilhelm-Strasse 100, Duisburg, Germany richard.thiessen@thyssenkrupp.com. LA - eng PT - Journal Article PL - England TA - Philos Trans A Math Phys Eng Sci JT - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences JID - 101133385 PMC - PMC5468725 OTO - NOTNLM OT - hydrogen embrittlement testing OT - microstructure OT - steel COIS- I declare that I have no competing interests. EDAT- 2017/06/14 06:00 MHDA- 2017/06/14 06:01 PMCR- 2018/07/28 CRDT- 2017/06/14 06:00 PHST- 2017/12/13 00:00 [accepted] PHST- 2017/06/14 06:00 [entrez] PHST- 2017/06/14 06:00 [pubmed] PHST- 2017/06/14 06:01 [medline] PHST- 2018/07/28 00:00 [pmc-release] AID - rsta.2016.0408 [pii] AID - rsta20160408 [pii] AID - 10.1098/rsta.2016.0408 [doi] PST - ppublish SO - Philos Trans A Math Phys Eng Sci. 2017 Jul 28;375(2098):20160408. doi: 10.1098/rsta.2016.0408. PMID- 19937565 OWN - NLM STAT- MEDLINE DCOM- 20100202 LR - 20091125 IS - 1439-4421 (Electronic) IS - 0941-3790 (Linking) VI - 71 IP - 11 DP - 2009 Nov TI - [EUREGIO MRSA-net Twente/Münsterland: "search & follow" by Euregional network building]. PG - 766-70 LID - 10.1055/s-0029-1241892 [doi] AB - Staphylococcus aureus causes the majority of healthcare-associated infections worldwide. Particularly critical are infections caused by methicillin-resistant Staphylococcus aureus (MRSA), for which there are few possibilities of antibiotic therapy. It is known that the occurrence of MRSA is directly associated with increased morbidity and mortality. There is also evidence for an increased lethality in hospital-acquired MRSA infections and MRSA bacteraemia in comparison to methicillin-sensitive S. aureus. Besides prolonged and severe disease conditions, the occurrence of MRSA results is extremely laborious and has for the hospitals very expensive consequences, in extreme cases the closure of an entire ward. Nosocomial infections due to MRSA lead to a significantly prolonged length of stay of the patient and leads therefore to extra costs due to recommended hygiene measures (e. g. isolation in a single room). The long-term treatment options can have side effects and are often limited to expensive antibiotics. The growing number of patients treated with severe underlying diseases and the increasing number of expensive medical treatments leads to a further exacerbation of this situation. In times of limited financial resources, this might lead to irresolvable conflicts between the patient safety required and the health funding available. CI - Copyright Georg Thieme Verlag KG Stuttgart . New York. FAU - Friedrich, A W AU - Friedrich AW AD - Institut für Hygiene des Universitätsklinikums Münster. alexander.friedrich@ukmuenster.de LA - ger PT - English Abstract PT - Journal Article TT - EUREGIO MRSA-net Twente/Münsterland: Search & Follow durch euregionale Netzwerkbildung. DEP - 20091123 PL - Germany TA - Gesundheitswesen JT - Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) JID - 9204210 SB - IM MH - Community Networks/*trends MH - Delivery of Health Care/*trends MH - Europe MH - Humans MH - *Methicillin-Resistant Staphylococcus aureus MH - Staphylococcal Infections/*prevention & control EDAT- 2009/11/26 06:00 MHDA- 2010/02/03 06:00 CRDT- 2009/11/26 06:00 PHST- 2009/11/26 06:00 [entrez] PHST- 2009/11/26 06:00 [pubmed] PHST- 2010/02/03 06:00 [medline] AID - 10.1055/s-0029-1241892 [doi] PST - ppublish SO - Gesundheitswesen. 2009 Nov;71(11):766-70. doi: 10.1055/s-0029-1241892. Epub 2009 Nov 23. PMID- 30803339 OWN - NLM STAT- MEDLINE DCOM- 20200123 LR - 20200801 IS - 2385-2011 (Electronic) IS - 1591-0199 (Print) IS - 1591-0199 (Linking) VI - 25 IP - 4 DP - 2019 Aug TI - Lyophilizing thrombin powder-based treatment for hemostasis during coil embolization of ruptured cerebral aneurysm: Two case reports. PG - 454-459 LID - 10.1177/1591019918824866 [doi] AB - BACKGROUND: Rupture of cerebral aneurysm is an inevitable complication during embolization, followed by subsequent acute subarachnoid hemorrhage or intracranial hematoma, and results in the aggravation of a patient's condition. In particular, for patients who have had a ruptured aneurysm, urgent treatment strategies are required during operation. The most common hemostatic methods seen in clinical practices are as follows: after lowering the blood pressure, we continue to embolize the aneurysms with detachable coils as soon as possible or inject with Glubran/Onyx embolization liquids, as well as use a balloon catheter to temporarily block the blood supply. If the conditions are permissible, a balloon guiding catheter may even be used to restrict the proximal blood flow. At times, due to limitations of these methods, neurosurgeons are requested to perform craniotomy to treat the hemostasis. However, the delayed transition often leads to rapid deterioration of the patient's condition and even death due to cerebral hernia. CASE DESCRIPTION: We herein presented two cases of ruptured cerebral aneurysms to provide an alternative method for hemostasis and to save the lives of patients as much as possible. In an extremely urgent situation (conventional treatment is ineffective), we successfully saved the patient's life by injecting lyophilizing thrombin powder (LTP) solution into the aneurysmal sac and the parent artery through a microcatheter. CONCLUSIONS: To our knowledge, this is the first report of successful hemostasis during coil embolization of ruptured cerebral aneurysm with LTP. Further prospective studies are needed to confirm the safety and efficacy of LTP in cerebrovascular interventional therapy. FAU - Jiang, Changchun AU - Jiang C AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Wang, Wei AU - Wang W AUID- ORCID: 0000-0001-7282-4154 AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Wang, Baojun AU - Wang B AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Li, Yuechun AU - Li Y AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Liu, Guorong AU - Liu G AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Zhang, Tianyou AU - Zhang T AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Fan, Yu AU - Fan Y AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Yang, Junfeng AU - Yang J AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Li, Xia AU - Li X AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Hao, Xiwa AU - Hao X AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Hao, Fei AU - Hao F AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Zhao, Junmei AU - Zhao J AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Wang, Shuguang AU - Wang S AD - 1 Department of Neurology, Baotou City Central Hospital, Cerebrovascular Disease Research Institute of Inner Mongolia Autonomous Region, China. FAU - Jiang, Chuhan AU - Jiang C AUID- ORCID: 0000-0003-2560-8576 AD - 2 Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. LA - eng PT - Case Reports PT - Journal Article DEP - 20190225 PL - United States TA - Interv Neuroradiol JT - Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences JID - 9602695 RN - 0 (Powders) RN - EC 3.4.21.5 (Thrombin) SB - IM MH - Aged MH - Aneurysm, Ruptured/*therapy MH - Embolization, Therapeutic/*methods MH - Female MH - Freeze Drying MH - *Hemostatic Techniques MH - Humans MH - Intracranial Aneurysm/*therapy MH - Middle Aged MH - Powders MH - Thrombin/*therapeutic use PMC - PMC6607606 OTO - NOTNLM OT - Lyophilizing thrombin powder OT - cerebral aneurysm embolization OT - hemostasis EDAT- 2019/02/26 06:00 MHDA- 2020/01/24 06:00 PMCR- 2020/08/01 CRDT- 2019/02/27 06:00 PHST- 2019/02/26 06:00 [pubmed] PHST- 2020/01/24 06:00 [medline] PHST- 2019/02/27 06:00 [entrez] PHST- 2020/08/01 00:00 [pmc-release] AID - 10.1177_1591019918824866 [pii] AID - 10.1177/1591019918824866 [doi] PST - ppublish SO - Interv Neuroradiol. 2019 Aug;25(4):454-459. doi: 10.1177/1591019918824866. Epub 2019 Feb 25. PMID- 23059356 OWN - NLM STAT- MEDLINE DCOM- 20130415 LR - 20121112 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 30 IP - 49 DP - 2012 Nov 19 TI - A qualitative study investigating knowledge and attitudes regarding human papillomavirus (HPV) and the HPV vaccine among parents of immunosuppressed children. PG - 7027-31 LID - S0264-410X(12)01398-9 [pii] LID - 10.1016/j.vaccine.2012.09.066 [doi] AB - Barriers influencing the willingness of parents to vaccinate immunocompetent children include a lack of knowledge about human papillomavirus (HPV) and low perception of risk regarding their child's acquisition of HPV infection. However, it cannot be assumed that the facilitators and barriers of HPV vaccination are the same for parents/guardians of children who are immunocompromised, or who have chronic medical conditions. This study aimed to document the knowledge and attitudes of parents/guardians of immunosuppressed children and adolescents towards HPV infection and the vaccine. A study using qualitative methods which incorporated 27 semi-structured interviews was undertaken with parents/guardians of immunosuppressed children vaccinated against HPV at three hospitals in two states of Australia. Thematic analysis revealed that while participants acknowledged that they had heard of HPV, they did not have a strong sense of what it actually was. The level of concern held about their child acquiring an HPV infection (prior to vaccination) ranged from 'not at all' to 'extremely'. Some believed that their child was at increased risk of developing a severe HPV-related illness because of their underlying condition. The participants supported their child receiving the HPV vaccine, as they did not want to take a risk with a disease that may cause their child to return to hospital for treatment. The majority had little apprehension about the use of the HPV vaccine but expressed some concern that potential adverse effects would be more severe for immunosuppressed children. However, they stressed their belief in the safety of the vaccine and their trust in the child's health team. Our study results show that parents of children with impaired immunity would benefit from further information about the safety of the vaccine and about the important role of the vaccine for boys as well as girls. CI - Copyright © 2012 Elsevier Ltd. All rights reserved. FAU - Seale, Holly AU - Seale H AD - School of Public Health & Community Medicine, University of New South Wales, Sydney 2052, Australia. h.seale@unsw.edu.au FAU - Trung, Linda AU - Trung L FAU - Mackie, Fiona E AU - Mackie FE FAU - Kennedy, Sean E AU - Kennedy SE FAU - Boros, Christina AU - Boros C FAU - Marshall, Helen AU - Marshall H FAU - Tidswell, Jane AU - Tidswell J FAU - Shaw, Peter J AU - Shaw PJ FAU - Montgomery, Kay AU - Montgomery K FAU - MacIntyre, C Raina AU - MacIntyre CR LA - eng PT - Journal Article DEP - 20121008 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Papillomavirus Vaccines) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Australia MH - Child MH - Child, Preschool MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Humans MH - Immunocompromised Host MH - Interviews as Topic MH - Male MH - Middle Aged MH - Papillomavirus Infections/complications/*prevention & control MH - Papillomavirus Vaccines/*administration & dosage/*immunology MH - *Parents MH - Uterine Cervical Neoplasms/*prevention & control EDAT- 2012/10/13 06:00 MHDA- 2013/04/16 06:00 CRDT- 2012/10/13 06:00 PHST- 2012/04/20 00:00 [received] PHST- 2012/09/06 00:00 [revised] PHST- 2012/09/26 00:00 [accepted] PHST- 2012/10/13 06:00 [entrez] PHST- 2012/10/13 06:00 [pubmed] PHST- 2013/04/16 06:00 [medline] AID - S0264-410X(12)01398-9 [pii] AID - 10.1016/j.vaccine.2012.09.066 [doi] PST - ppublish SO - Vaccine. 2012 Nov 19;30(49):7027-31. doi: 10.1016/j.vaccine.2012.09.066. Epub 2012 Oct 8. PMID- 19300757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20211020 IS - 0022-300X (Print) IS - 0022-300X (Linking) VI - 13 IP - 3 DP - 1981 Jul TI - Biological control potential of neoaplectanid nematodes. PG - 241-9 AB - The neoaplectanids are among the most studied of all entomogenous nematodes. Because these nematodes kill their insect hosts, they are regarded as having excellent potential as biological control agents. While the host specificity of most entontogenous nematodes tends to limit their potential usefulness, the broad host range and high virulence of neoaplectanids make them attractive candidates for industrial development. Also, recent development of economical mass rearing procedures appears to make production on a commercial basis feasible. Infective stages may be stored for years trader various laboratory conditions. Although entomogenous nematodes, as parasites, are exempt from govermnent registration requirements, the mutualistic association of neoaplectanid nematodes with a bacterium will likely necessitate a detailed safety evaluation. Studies conducted to date indicate a lack of pathogenicity to mammals. Field trial success has been limited by the intolerance of infective stages to mffavorable environmental conditions, particularly low moisture. Applications against pests on exposed plant foliage have been especially disappointing. More encouraging anti consistent results have been obtained in more favorable environments, including soil and aquatic habitats, but the most promising treatment sites ntay be cryptic habitats where infective stages are shehered from environmental extremes. Cryptic habitats also exploit the ability of neoaplectanids to actively seek out hosts in recessed places where conventional insecticide applications are intpractical. FAU - Gaugler, R AU - Gaugler R LA - eng PT - Journal Article PL - Poland TA - J Nematol JT - Journal of nematology JID - 9884299 PMC - PMC2618097 OTO - NOTNLM OT - Neoaplectana bibionis OT - Neoaplectana carpocapsae OT - Neoapleetana glaseri OT - entomogenous nematodes EDAT- 1981/07/01 00:00 MHDA- 1981/07/01 00:01 PMCR- 1981/07/01 CRDT- 2009/03/21 09:00 PHST- 2009/03/21 09:00 [entrez] PHST- 1981/07/01 00:00 [pubmed] PHST- 1981/07/01 00:01 [medline] PHST- 1981/07/01 00:00 [pmc-release] PST - ppublish SO - J Nematol. 1981 Jul;13(3):241-9. PMID- 32474528 OWN - NLM STAT- MEDLINE DCOM- 20200921 LR - 20200921 IS - 1998-4138 (Electronic) IS - 1998-4138 (Linking) VI - 16 IP - 2 DP - 2020 TI - Transcatheter arterial infusion of anti-programmed cell death 1 antibody pembrolizumab combined with temozolomide or nab-paclitaxel in patient with primary anorectal malignant melanoma: Four case reports. PG - 387-392 LID - 10.4103/jcrt.JCRT_75_20 [doi] AB - Primary anorectal malignant melanoma (ARMM) is an extremely rare but aggressive tumor. We assessed the efficacy and safety of transcatheter arterial infusion (TAI) with anti-PD-1 antibody pembrolizumab at a dosage of 100 mg with 0.9% NaCl at a volume of 100 mL administered over a 30-min period every 3 weeks, combined with temozolomide or albumin-bound paclitaxel (nab-paclitaxel) in four patients with ARMM. Temozolomide was administered orally once per day at a dosage of 200 mg/m2/d for five consecutive days about every 4 weeks. Nab-paclitaxel was administered at a dosage of 200mg/m2/d once about every 3 weeks. Among four patients with a median follow-up of 8.9 months, two cases showed Murine Double Minute 2 (MDM2) amplification. Case 1 with Stage II ARMM showed pathological complete response after four cycles of TAI with pembrolizumab combined with nab-paclitaxel. Case 4 was at Stage II and showed stable disease consistently throughout the treatment. Case 2 was at stage II and Case 3 was at stage III, and they showed partial response after four or three cycles, respectively, of TAI with pembrolizumab combined with temozolomide. No Grades 3-4 adverse reactions were observed. Therefore, a combination of TAI with pembrolizumab and temozolomide or with nab-paclitaxel appears to be a promising option for treating ARMM. However, multicenter clinical trials are required to confirm the efficacy and safety of this procedure. FAU - Chen, Shuanggang AU - Chen S AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Zhang, Xiaoshi AU - Zhang X AD - Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China; Department of Biotherapy Center, Sun Yat-Sen University Cancer Center, Guangzhou, China. FAU - Shen, Lujun AU - Shen L AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Qi, Han AU - Qi H AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Ma, Weimei AU - Ma W AD - Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China; Department of Imaging Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China. FAU - Cao, Fei AU - Cao F AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Xie, Lin AU - Xie L AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Song, Ze AU - Song Z AD - Department of Medical Imaging, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China. FAU - Wu, Ying AU - Wu Y AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. FAU - Li, Dandan AU - Li D AD - Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China; Department of Biotherapy Center, Sun Yat-Sen University Cancer Center, Guangzhou, China. FAU - Wen, Xizhi AU - Wen X AD - Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China; Department of Biotherapy Center, Sun Yat-Sen University Cancer Center, Guangzhou, China. FAU - Fan, Weijun AU - Fan W AD - Department of Minimally Invasive Interventional Therapy; Collaborative Innovation Center of Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou, China. LA - eng PT - Case Reports PT - Journal Article PL - India TA - J Cancer Res Ther JT - Journal of cancer research and therapeutics JID - 101249598 RN - 0 (130-nm albumin-bound paclitaxel) RN - 0 (Albumins) RN - 0 (Antibodies, Monoclonal, Humanized) RN - DPT0O3T46P (pembrolizumab) RN - P88XT4IS4D (Paclitaxel) RN - YF1K15M17Y (Temozolomide) SB - IM MH - Adult MH - Albumins/administration & dosage MH - Antibodies, Monoclonal, Humanized/administration & dosage MH - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use MH - Anus Neoplasms/*drug therapy/pathology MH - Female MH - Humans MH - Infusions, Intra-Arterial/*methods MH - Melanoma/*drug therapy/pathology MH - Middle Aged MH - Paclitaxel/administration & dosage MH - Patient Safety MH - Rectal Neoplasms/*drug therapy/pathology MH - Temozolomide/administration & dosage MH - Treatment Outcome OTO - NOTNLM OT - Nab-paclitaxel OT - oral temozolomide OT - pembrolizumab OT - primary anorectal malignant melanoma OT - transcatheter arterial infusion COIS- None EDAT- 2020/06/01 06:00 MHDA- 2020/09/22 06:00 CRDT- 2020/06/01 06:00 PHST- 2020/06/01 06:00 [entrez] PHST- 2020/06/01 06:00 [pubmed] PHST- 2020/09/22 06:00 [medline] AID - JCanResTher_2020_16_2_387_285198 [pii] AID - 10.4103/jcrt.JCRT_75_20 [doi] PST - ppublish SO - J Cancer Res Ther. 2020;16(2):387-392. doi: 10.4103/jcrt.JCRT_75_20. PMID- 22288029 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20211021 IS - 2210-2612 (Electronic) IS - 2210-2612 (Linking) VI - 3 IP - 1 DP - 2012 TI - Enterobius vermicularis (pinworm) infection of the liver mimicking malignancy: Presentation of a new case and review of current literature. PG - 6-9 LID - 10.1016/j.ijscr.2011.10.003 [doi] AB - INTRODUCTION: Enterobius vermicularis or "pinworm" infection of the liver is an extremely rare condition with only five cases previously reported in literature. It is characterized by the presence of granulomas in the liver with a necrotic core, containing adult helminthes or their ova. Because of the relatively mild symptomatology associated with this disease, prior to the arrival of modern imaging methods hepatic enterobiasis was an incidental intra-operative finding during abdominal surgery for other conditions. In recent years however, with high-resolution abdominal imaging readily available and the improved safety of hepatic resection, a lower threshold for treating suspicious hepatic nodules aggressively with surgery is being adopted. PRESENTATION OF CASE: We present the second case in international literature, where E. vermicularis of the liver was mistaken for malignancy and led to hepatic resection and perform a literature review of the five previously documented cases of hepatic enterobiasis. DISCUSSION: Our report identifies certain trends in this condition's aetiology and clinical behaviour, but due to its rarity definitive answers cannot yet be established. CONCLUSION: We do not advocate a change in the current approach of suspicious hepatic nodules, but we do feel that better understanding of the mechanisms involved with hepatic enterobiasis could, in the future, prevent unnecessary surgery. FAU - Arkoulis, Nikolaos AU - Arkoulis N AD - Department of Plastic Surgery, St. John's Hospital, Livingston, Scotland EH54 6PP, UK. FAU - Zerbinis, Helen AU - Zerbinis H FAU - Simatos, Georgios AU - Simatos G FAU - Nisiotis, Athanasios AU - Nisiotis A LA - eng PT - Journal Article DEP - 20111019 PL - Netherlands TA - Int J Surg Case Rep JT - International journal of surgery case reports JID - 101529872 PMC - PMC3267245 OTO - NOTNLM OT - Enterobius vermicularis OT - Hepatic granuloma OT - Necrotic liver nodule EDAT- 2012/01/31 06:00 MHDA- 2012/01/31 06:01 PMCR- 2011/10/19 CRDT- 2012/01/31 06:00 PHST- 2011/06/04 00:00 [received] PHST- 2011/10/01 00:00 [revised] PHST- 2011/10/10 00:00 [accepted] PHST- 2012/01/31 06:00 [entrez] PHST- 2012/01/31 06:00 [pubmed] PHST- 2012/01/31 06:01 [medline] PHST- 2011/10/19 00:00 [pmc-release] AID - IJSCR119 [pii] AID - 10.1016/j.ijscr.2011.10.003 [doi] PST - ppublish SO - Int J Surg Case Rep. 2012;3(1):6-9. doi: 10.1016/j.ijscr.2011.10.003. Epub 2011 Oct 19. PMID- 22404883 OWN - NLM STAT- MEDLINE DCOM- 20130708 LR - 20131121 IS - 1423-0410 (Electronic) IS - 0042-9007 (Linking) VI - 103 IP - 2 DP - 2012 Aug TI - Repeated short-term warming of red blood cell concentrates has minimal effect on their quality. PG - 113-21 LID - 10.1111/j.1423-0410.2012.01589.x [doi] AB - BACKGROUND AND OBJECTIVES: Blood components must be stored under controlled temperature conditions, for reasons of component quality and safety. However, there are occasions when components may be exposed to conditions outwith the defined limits. This study aimed to generate prospective data on the effect of red cell exposure to extremes of temperature. MATERIALS AND METHODS: Study 1: red cell concentrates (RCC) in saline, adenine, glucose and mannitol (SAGM), made after ambient overnight hold of whole blood, were exposed to either +22°C or -2°C for up to three periods of 3 h on days 3, 8 and 15 of storage, followed by a 5 h exposure on day 29. Study 2: RCC in SAGM were exposed to 25°C for 24 or 48 h from day 2. In vitro markers of cell quality were measured during storage to 43 days, and compared with control units that had been stored at 2-6°C. RESULTS: Multiple short-term exposures to +22°C or -2°C did not cause any significant changes to pH, haemolysis, supernatant potassium, cellular ATP, 2,3-DPG, or deformability, when compared to control units. Exposure of RCC to 25°C for 24 or 48 h caused a significant fall in pH, ATP, and deformability. CONCLUSION: Red cells may be damaged by prolonged exposure to warm temperatures, but repeated short-term exposure to 22°C or -2°C does not appear to affect the in vitro quality of RCC. It is important to note that no bacterial growth studies were performed during this study. CI - © 2012 The Author(s). Vox Sanguinis © 2012 International Society of Blood Transfusion. FAU - Thomas, S AU - Thomas S AD - Components Development Laboratory, NHS Blood & Transplant, Brentwood, UK. stephen.thomas@nhsbt.nhs.uk FAU - Hancock, V AU - Hancock V FAU - Cardigan, R AU - Cardigan R LA - eng PT - Journal Article DEP - 20120310 PL - England TA - Vox Sang JT - Vox sanguinis JID - 0413606 RN - 0 (Preservatives, Pharmaceutical) RN - 8L70Q75FXE (Adenosine Triphosphate) RN - RWP5GA015D (Potassium) SB - IM MH - Adenosine Triphosphate/metabolism MH - *Blood Preservation MH - *Erythrocyte Transfusion MH - Erythrocytes/*cytology/*metabolism MH - Female MH - Hemolysis/drug effects MH - Humans MH - Male MH - Potassium/metabolism MH - Preservatives, Pharmaceutical/pharmacology MH - Quality Control MH - Time Factors EDAT- 2012/03/13 06:00 MHDA- 2013/07/09 06:00 CRDT- 2012/03/13 06:00 PHST- 2012/03/13 06:00 [entrez] PHST- 2012/03/13 06:00 [pubmed] PHST- 2013/07/09 06:00 [medline] AID - 10.1111/j.1423-0410.2012.01589.x [doi] PST - ppublish SO - Vox Sang. 2012 Aug;103(2):113-21. doi: 10.1111/j.1423-0410.2012.01589.x. Epub 2012 Mar 10. PMID- 38864724 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240612 IS - 1089-7623 (Electronic) IS - 0034-6748 (Linking) VI - 95 IP - 6 DP - 2024 Jun 1 TI - Research on rolling bearing fault diagnosis method based on simulation and experiment fusion drive. LID - 065107 [pii] LID - 10.1063/5.0212888 [doi] AB - Aiming at the problem that the rolling bearing fault data are difficult to obtain and that the traditional fault diagnosis method does not consider the signal uncertainty characteristics and the low accuracy of models in the process of rolling bearing fault, a fault diagnosis method based on simulation and experiment fusion drive is proposed. First, the dynamics simulation model of rolling bearings under different fault conditions is established to obtain the bearing fault simulation signals. Second, a sequence generative adversarial network is used to fuse the simulation and experimental data. Bearing vibration signals are often very uncertain, so considering the probability characteristics of fault signals, the probability box model under different fault states is constructed by the direct probability box modeling method, and its characteristic vectors are extracted. Finally, an extreme gradient boosting Tree model for fault diagnosis classification is constructed to compare and evaluate the classification and diagnosis effects of bearing states before and after data fusion. The results show that the proposed method has a good diagnostic effect and is suitable for solving the fault diagnosis problem under the condition of insufficient data. CI - © 2024 Author(s). Published under an exclusive license by AIP Publishing. FAU - Li, Yonghua AU - Li Y AUID- ORCID: 0000-0001-7935-9152 AD - College of Locomotive and Rolling Stock Engineering, Dalian Jiaotong University, Dalian 116028, China. AD - Key Laboratory of Railway Industry on Safety Service Key Technologies for High-Speed Train, Dalian Jiaotong University, Dalian 116028, China. FAU - Wang, Denglong AU - Wang D AUID- ORCID: 0009-0000-3866-5778 AD - College of Locomotive and Rolling Stock Engineering, Dalian Jiaotong University, Dalian 116028, China. FAU - Zhao, Xin AU - Zhao X AD - College of Locomotive and Rolling Stock Engineering, Dalian Jiaotong University, Dalian 116028, China. FAU - Men, Zhihui AU - Men Z AUID- ORCID: 0000-0002-1257-4293 AD - College of Locomotive and Rolling Stock Engineering, Dalian Jiaotong University, Dalian 116028, China. FAU - Wang, Yipeng AU - Wang Y AD - College of Locomotive and Rolling Stock Engineering, Dalian Jiaotong University, Dalian 116028, China. LA - eng PT - Journal Article PL - United States TA - Rev Sci Instrum JT - The Review of scientific instruments JID - 0405571 SB - IM EDAT- 2024/06/12 12:42 MHDA- 2024/06/12 12:43 CRDT- 2024/06/12 09:43 PHST- 2024/04/07 00:00 [received] PHST- 2024/05/30 00:00 [accepted] PHST- 2024/06/12 12:43 [medline] PHST- 2024/06/12 12:42 [pubmed] PHST- 2024/06/12 09:43 [entrez] AID - 3297919 [pii] AID - 10.1063/5.0212888 [doi] PST - ppublish SO - Rev Sci Instrum. 2024 Jun 1;95(6):065107. doi: 10.1063/5.0212888. PMID- 10470816 OWN - NLM STAT- MEDLINE DCOM- 19990910 LR - 20221207 IS - 0022-3085 (Print) IS - 0022-3085 (Linking) VI - 91 IP - 3 DP - 1999 Sep TI - Percutaneous transluminal angioplasty for intracranial atherosclerotic lesions: evolution of technique and short-term results. PG - 415-23 AB - OBJECT: A retrospective analysis of a 9-year experience with balloon angioplasty for intracranial atherosclerotic stenosis was undertaken with the goals of illustrating development of a safe technique for treatment of intracranial atherosclerotic disease and reporting the immediate results in this series of patients. METHODS: Three distinct periods are defined, based on the technique used. In the early period, in which eight patients were treated, the angioplasty balloon size approximated the vessel size, but was always smaller. Angioplasty was moderately rapid and brief (15-30 seconds). Clinical improvement occurred in seven (87.5%) of eight patients, dissection without consequence occurred in four (50%) of eight, and residual stenosis greater than 50% was found in three (37.5%) of eight. No neurological complications occurred. In the middle period, in which 12 patients were treated, the balloon size approximated the vessel size, but oversizing by up to 0.25 mm was permitted. Angioplasty was extremely rapid and brief. Angiographically visible dissection occurred in nine (75%) of 12 patients, necessitating urokinase infusion in five (41.7%) of 12 and producing abrupt occlusion in one (8.3%) of 12, resulting in death. Occlusion secondary to the recrossing of the lesion occurred in one (8.3%) of 12, resulting in stroke. Good outcome was eventually achieved in 10 (83.3%) of 12. In the current period, in which 50 patients have been treated, the balloon is always undersized and inflation is extremely slow (several minutes). Dissection occurred in seven (14%) of 50 patients, necessitating fibrinolysis in two of 50 (4%, both uneventful) and producing no abrupt occlusion or stroke. Residual stenosis greater than 50% occurred in eight (16%) of 50, with no stenosis greater than 70%. Late restenosis occurred in four (9%) of 44 and successful repeated angioplasty was performed in all four. One guidewire vessel perforation occurred (2%), resulting in the patient's death. Good angiographic and short-term clinical outcome was achieved in the other 49 patients (98%). CONCLUSIONS: Extremely slow balloon inflation combined with balloon undersizing results in decreased intimal damage, decreased acute platelet/thrombus deposition, and decreased acute closure. This technique sometimes yields suboptimal angiographic results but achieves the clinical goal safely. Intracranial angioplasty can be safely performed using this technique and modern equipment. FAU - Connors, J J 3rd AU - Connors JJ 3rd AD - Department of Radiology, Louisiana State University School of Medicine, New Orleans, USA. budmancon@aol.com FAU - Wojak, J C AU - Wojak JC LA - eng PT - Journal Article PL - United States TA - J Neurosurg JT - Journal of neurosurgery JID - 0253357 RN - EC 3.4.21.- (Plasminogen Activators) RN - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator) SB - IM MH - Aortic Dissection/diagnostic imaging/drug therapy/etiology MH - Angioplasty, Balloon/adverse effects/instrumentation/*methods MH - Arterial Occlusive Diseases/etiology MH - Cause of Death MH - Cerebral Angiography MH - Cerebral Arterial Diseases/etiology MH - Cerebral Arteries/injuries MH - Cerebrovascular Disorders/etiology MH - Equipment Design MH - Follow-Up Studies MH - Humans MH - Infusions, Intravenous MH - Intracranial Aneurysm/diagnostic imaging/drug therapy/etiology MH - Intracranial Arteriosclerosis/diagnostic imaging/*therapy MH - Middle Aged MH - Plasminogen Activators/administration & dosage/therapeutic use MH - Platelet Aggregation MH - Recurrence MH - Retreatment MH - Retrospective Studies MH - Safety MH - Thrombolytic Therapy MH - Time Factors MH - Treatment Outcome MH - Tunica Intima/pathology MH - Urokinase-Type Plasminogen Activator/administration & dosage/therapeutic use EDAT- 1999/09/02 09:00 MHDA- 2001/03/28 10:01 CRDT- 1999/09/02 09:00 PHST- 1999/09/02 09:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1999/09/02 09:00 [entrez] AID - 10.3171/jns.1999.91.3.0415 [doi] PST - ppublish SO - J Neurosurg. 1999 Sep;91(3):415-23. doi: 10.3171/jns.1999.91.3.0415. PMID- 39951851 OWN - NLM STAT- Publisher LR - 20250214 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 474 DP - 2025 Feb 5 TI - Tunning "closed-loop" pockets for constructing stabilized structures of nanobody in the detection of procymidone under a broad range of pH value. PG - 143243 LID - S0308-8146(25)00494-7 [pii] LID - 10.1016/j.foodchem.2025.143243 [doi] AB - The tolerance advantages of nanobodies (Nbs) provide a new proposal for enhancing the stability and sensitivity of immunosensors. However, the tolerance of Nbs to extreme pH levels, has not been deeply investigated, as previous stability studies on Nbs had primarily focused on temperature and organic solvents. Here, a nanobody clone (NbFM5) is obtained and its tolerance is analyzed using molecular simulation and molecular docking. The simulation results reveal that the seven amino acids of NbFM5 and the ligand formed a "closed-loop" hydrophobic interaction pocket with highly electronegativity surface potential and net charges, which enhanced stability of configuration under varying pH conditions, thus ensuring the stability of the affinity. The results indicate that NbFM5 exhibited a mean antigen binding activity of 79.8 % across a pH range of 6 to 10 with standard deviation of 10 %, demonstrating high stability against a wide range of pH values. Given above, an aggregation-induced emission nanoparticles based lateral-flow biosensor is successfully established using NbFM5. The whole process of detecting procymidone is completed in 10 min with a detection limit of 0.19 ng/mL. The method has fully satisfied the need of rapid detection requirements in extreme environmental conditions and could establish a promising foodborne contaminants detection platform. CI - Copyright © 2024. Published by Elsevier Ltd. FAU - Huang, Hui-Wei AU - Huang HW AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. FAU - Qileng, Aori AU - Qileng A AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. FAU - Luo, Lin AU - Luo L AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. FAU - Wang, Yu AU - Wang Y AD - Guangzhou Institute of Food Inspection, Guangzhou 510410, China. FAU - Huang, Song AU - Huang S AD - Guangzhou Institute of Food Inspection, Guangzhou 510410, China. FAU - Shen, Yu-Dong AU - Shen YD AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. FAU - Liu, Min-Ling AU - Liu ML AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. FAU - Xu, Zhen-Lin AU - Xu ZL AD - Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. Electronic address: jallent@163.com. LA - eng PT - Journal Article DEP - 20250205 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 SB - IM OTO - NOTNLM OT - Aggregation-induced emission OT - Food safety OT - Immunosensor OT - Nanobody OT - Procymidone COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/02/15 15:11 MHDA- 2025/02/15 15:11 CRDT- 2025/02/14 18:00 PHST- 2024/07/16 00:00 [received] PHST- 2025/01/16 00:00 [revised] PHST- 2025/02/04 00:00 [accepted] PHST- 2025/02/15 15:11 [medline] PHST- 2025/02/15 15:11 [pubmed] PHST- 2025/02/14 18:00 [entrez] AID - S0308-8146(25)00494-7 [pii] AID - 10.1016/j.foodchem.2025.143243 [doi] PST - aheadofprint SO - Food Chem. 2025 Feb 5;474:143243. doi: 10.1016/j.foodchem.2025.143243. PMID- 34425288 OWN - NLM STAT- MEDLINE DCOM- 20210930 LR - 20210930 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 161 DP - 2021 Oct TI - A relative approach to the validation of surrogate measures of safety. PG - 106350 LID - S0001-4575(21)00381-X [pii] LID - 10.1016/j.aap.2021.106350 [doi] AB - Surrogate measures of safety (SMoS) are meant to be an alternative/complement to crash data that enables a proactive approach to traffic safety. Validity is a fundamental property of SMoS that describes how well they reflect the quality of interest - traffic safety. However, typical validation studies are extremely resource demanding. Therefore, the aim of this study was to explore a relative approach to validity that uses fewer resources and does not rely on crash records from the observed locations. The core idea of a relative approach to the validation of SMoS is that while SMoS might not accurately estimate the expected number of crashes, they still work well for comparisons between different sites or between conditions at the same site. Based on this concept, we propose a method in which a ground truth based on literature can be used as a baseline that can then be compared to the safety analysis of an SMoS study. Using the proposed method, a case study of six intersections in northern Europe was conducted, focusing on bicycle infrastructure. The results indicate that the minimum time-to-collision indicator is in line with the ground truth, whereas the post-encroachment time indicator is not. CI - Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Johnsson, Carl AU - Johnsson C AD - Department of Technology and Society, Faculty of Engineering, LTH Lund University, Lund, Sweden. Electronic address: carl.johnsson@tft.lth.se. FAU - Laureshyn, Aliaksei AU - Laureshyn A AD - Department of Technology and Society, Faculty of Engineering, LTH Lund University, Lund, Sweden. Electronic address: aliaksei.laureshyn@tft.lth.se. FAU - Dágostino, Carmelo AU - Dágostino C AD - Department of Technology and Society, Faculty of Engineering, LTH Lund University, Lund, Sweden. Electronic address: carmelo.dagostino@tft.lth.se. LA - eng PT - Journal Article DEP - 20210821 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - *Accidents, Traffic/prevention & control MH - *Environment Design MH - Europe MH - Safety OTO - NOTNLM OT - Bicyclists OT - Relative validation OT - Surrogate measures of safety EDAT- 2021/08/24 06:00 MHDA- 2021/10/01 06:00 CRDT- 2021/08/23 20:16 PHST- 2020/08/20 00:00 [received] PHST- 2021/07/12 00:00 [revised] PHST- 2021/08/08 00:00 [accepted] PHST- 2021/08/24 06:00 [pubmed] PHST- 2021/10/01 06:00 [medline] PHST- 2021/08/23 20:16 [entrez] AID - S0001-4575(21)00381-X [pii] AID - 10.1016/j.aap.2021.106350 [doi] PST - ppublish SO - Accid Anal Prev. 2021 Oct;161:106350. doi: 10.1016/j.aap.2021.106350. Epub 2021 Aug 21. PMID- 10945557 OWN - NLM STAT- MEDLINE DCOM- 20000912 LR - 20190718 IS - 0004-8682 (Print) IS - 0004-8682 (Linking) VI - 70 IP - 8 DP - 2000 Aug TI - The safety of electrolytically induced hepatic necrosis in a pig model. PG - 607-12 AB - BACKGROUND: Electrolysis fulfils the criteria for an ideal treatment of patients with unresectable liver tumours. Previous studies in the rat and pig have shown that controlled necrosis can be safely produced by inserting platinum electrodes into normal liver' parenchyma and liver tumours. As with any new treatment it is mandatory to investigate the 'worst-case scenario' of inadvertent intravascular electrode placement in a large animal model before progressing to clinical trials. METHODS: Under ultrasound control in six pigs, electrodes were inserted into, or immediately adjacent to, an hepatic vein. An electrolytic 'dose' of 100 C was then administered and the evolution of the lesion was monitored using ultrasound. Venous blood was collected before and during the electrolysis to evaluate potential acid/base disturbances and animals were closely monitored during electrolysis and during their recovery until a full autopsy was performed 4-7 days after treatment. RESULTS: Gas bubbles were seen to enter the hepatic veins or interior vena cava during treatment in five of the six animals. There were no major complications as a consequence and all animals recovered and remained in a healthy state until they were killed. At autopsy one animal had complete thrombotic occlusion of the left hepatic vein. Otherwise, findings were normal. CONCLUSION: In the clinical setting, due to the use of ultrasound to guide electrode placement into the centre of a tumour, the electrodes should rarely juxtapose an hepatic vein. Nevertheless, in this extreme situation, electrolysis is surprisingly safe with only one major vascular occlusion and no morbidity or mortality. FAU - Wemyss-Holden, S A AU - Wemyss-Holden SA AD - University of Adelaide Department of Surgery, Queen Elizabeth Hospital, Woodville, South Australia. FAU - de la M Hall, P AU - de la M Hall P FAU - Robertson, G S AU - Robertson GS FAU - Dennison, A R AU - Dennison AR FAU - Vanderzon, P S AU - Vanderzon PS FAU - Maddern, G J AU - Maddern GJ LA - eng PT - Journal Article PL - Australia TA - Aust N Z J Surg JT - The Australian and New Zealand journal of surgery JID - 0373115 SB - IM MH - Animals MH - *Disease Models, Animal MH - Electric Stimulation Therapy/*adverse effects/instrumentation/*methods MH - Electrolysis MH - Female MH - Hepatic Veins/diagnostic imaging/injuries/pathology MH - Liver/diagnostic imaging/*injuries/pathology MH - Liver Neoplasms/*therapy MH - Monitoring, Physiologic MH - Necrosis MH - Rats MH - *Safety MH - Swine MH - Ultrasonography, Interventional EDAT- 2000/08/17 11:00 MHDA- 2000/09/19 11:01 CRDT- 2000/08/17 11:00 PHST- 2000/08/17 11:00 [pubmed] PHST- 2000/09/19 11:01 [medline] PHST- 2000/08/17 11:00 [entrez] AID - 10.1046/j.1440-1622.2000.01907.x [doi] PST - ppublish SO - Aust N Z J Surg. 2000 Aug;70(8):607-12. doi: 10.1046/j.1440-1622.2000.01907.x. PMID- 14716730 OWN - NLM STAT- MEDLINE DCOM- 20040331 LR - 20071115 IS - 0277-6715 (Print) IS - 0277-6715 (Linking) VI - 23 IP - 2 DP - 2004 Jan 30 TI - Analytical, practical and regulatory issues in prevention studies. PG - 297-303 AB - Prevention studies, as distinguished from studies investigating treatments for established disease, present some distinct challenges. Perhaps the most extensive experience with preventive agents is in the area of infectious diseases; vaccines have been extremely effective in preventing many such diseases. Vaccines have been, and continue to be, studied in other disease areas such as certain cancers, but as yet have not achieved success outside of infectious disease prevention. One obvious and important feature of prevention studies is that they enroll healthy individuals; thus such studies require particularly high standards for the safety of those enrolled (and those who might ultimately receive the product being tested). Prevention studies often need to be quite large, as the types of diseases most important to prevent tend to be uncommon. Large studies usually require simplified approaches; to ensure high quality of data on the key variables it may be necessary to compromise on the amount of data collected, frequency of data collection, and other aspects of trial design. The reliability of randomization and blinding may be especially important in these large studies, as bias could easily overwhelm the small effects that are usually sought. Often, biomarkers thought to indicate developing but as yet subclinical disease, will be important to evaluate; whether such markers can serve as primary endpoints in prevention studies has been a contentious issue in many contexts. Studies in older populations, such as those at risk for Alzheimer's Disease, raise challenges such as accounting for competing risks, and considering potential interactions of preventive agents with multiple medications often used by the elderly. CI - Published in 2004 by John Wiley & Sons, Ltd. FAU - Ellenberg, Susan S AU - Ellenberg SS AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM-210, Rockville, MD 20852, USA. ellenberg@cber.fda.gov LA - eng PT - Journal Article PL - England TA - Stat Med JT - Statistics in medicine JID - 8215016 SB - IM MH - Clinical Trials as Topic/legislation & jurisprudence MH - Humans MH - Patient Selection MH - Preventive Medicine/legislation & jurisprudence/*organization & administration MH - Safety MH - *Treatment Outcome MH - United States EDAT- 2004/01/13 05:00 MHDA- 2004/04/01 05:00 CRDT- 2004/01/13 05:00 PHST- 2004/01/13 05:00 [pubmed] PHST- 2004/04/01 05:00 [medline] PHST- 2004/01/13 05:00 [entrez] AID - 10.1002/sim.1717 [doi] PST - ppublish SO - Stat Med. 2004 Jan 30;23(2):297-303. doi: 10.1002/sim.1717. PMID- 27166756 OWN - NLM STAT- MEDLINE DCOM- 20180807 LR - 20180807 IS - 1745-7319 (Electronic) IS - 1745-7300 (Linking) VI - 24 IP - 4 DP - 2017 Dec TI - Speed-profile-based road segmentation for accident occurrence modelling for hilly terrains. PG - 444-451 LID - 10.1080/17457300.2016.1178301 [doi] AB - Modelling the accident occurrences per unit length of the road requires segmentation of road stretch. In the case of hilly terrains, homogeneity-based approach results in extremely small sections thus creating a biased accident data. This result is due to the high variations in geometry along the length of the road stretch. Constant length sections do not consider the effect of road's characteristics, hence may lead to undesirable results. It is hypothesized that the speed profile of a vehicle moving in free-flow conditions is governed by the road geometry as well as the road side environment. In this paper, a new methodology based on speed profile of a test vehicle (passenger car) has been proposed for segmenting a road stretch passing through hilly terrain. Comparative analysis of the results obtained from the constant length segmentation approach and the proposed approach shows that the later approach is producing statistically better results. Relatively more parameters were found to be statistically significant in the model based on speed-profile-based segmentation. Grade length, which could be one of the major parameters in hilly terrains, was found to be statistically significant only in the model based on speed-profile-based segmentation. FAU - Balusu, Surya Prasanna Kumar AU - Balusu SPK AD - a Civil Engineering Department , Indian Institute of Technology , Guwahati , India. FAU - Iraganaboina, Naveen Chandra AU - Iraganaboina NC AD - a Civil Engineering Department , Indian Institute of Technology , Guwahati , India. FAU - Shallam, Regulus Dominic K AU - Shallam RDK AD - a Civil Engineering Department , Indian Institute of Technology , Guwahati , India. FAU - Chunchu, Mallikarjuna AU - Chunchu M AD - a Civil Engineering Department , Indian Institute of Technology , Guwahati , India. LA - eng PT - Journal Article DEP - 20160511 PL - England TA - Int J Inj Contr Saf Promot JT - International journal of injury control and safety promotion JID - 101247254 SB - IM MH - Acceleration MH - *Accidents, Traffic MH - Deceleration MH - Environment MH - Environment Design MH - Geography MH - Humans MH - *Models, Theoretical MH - Safety OTO - NOTNLM OT - Poisson model OT - accident frequency OT - free-flow condition OT - segmentation OT - speed variation EDAT- 2016/05/12 06:00 MHDA- 2018/08/08 06:00 CRDT- 2016/05/12 06:00 PHST- 2016/05/12 06:00 [pubmed] PHST- 2018/08/08 06:00 [medline] PHST- 2016/05/12 06:00 [entrez] AID - 10.1080/17457300.2016.1178301 [doi] PST - ppublish SO - Int J Inj Contr Saf Promot. 2017 Dec;24(4):444-451. doi: 10.1080/17457300.2016.1178301. Epub 2016 May 11. PMID- 22925594 OWN - NLM STAT- MEDLINE DCOM- 20130225 LR - 20160520 IS - 2211-5684 (Electronic) IS - 2211-5684 (Linking) VI - 93 IP - 9 DP - 2012 Sep TI - Approaches in injections for radicular pain: the transforaminal, epidural and transfacet approaches. PG - 711-22 LID - 10.1016/j.diii.2012.07.005 [doi] AB - Spinal injections must be carried out adhering to very strict conditions. However, these procedures have almost come to be seen as everyday and may be practised under quite questionable conditions. The recent reports of new and extremely serious neurological complications have changed the attitudes of those making referrals as well as the attitudes of the interventional radiologists carrying out these procedures. The range of indications for transforaminal injections has shrunk in favour of epidural injections. Where the transforaminal approach is still used, the needle must be positioned extremely accurately. A prior radioopaque contrast medium injection is essential from a safety perspective. The transforaminal epidural injection via the transfacet approach looks to be a promising alternative that is strictly avascular. CI - Copyright © 2012 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved. FAU - Brunner, P AU - Brunner P AD - Princesse Grace Hospital, Monaco Cedex, Principality of Monaco. pbrunner@chpg.mc FAU - Amoretti, N AU - Amoretti N FAU - Soares, F AU - Soares F FAU - Brunner, E AU - Brunner E FAU - Cazaux, E AU - Cazaux E FAU - Brocq, O AU - Brocq O FAU - Chanalet, S AU - Chanalet S FAU - Liberatore, M AU - Liberatore M FAU - Cucchi, J-M AU - Cucchi JM FAU - Mourou, M-Y AU - Mourou MY FAU - Michelozzi, G AU - Michelozzi G FAU - Robino, C AU - Robino C LA - eng PT - Journal Article DEP - 20120825 PL - France TA - Diagn Interv Imaging JT - Diagnostic and interventional imaging JID - 101568499 SB - IM MH - Humans MH - Injections, Spinal/*methods MH - Pain/*drug therapy MH - *Spinal Nerve Roots EDAT- 2012/08/29 06:00 MHDA- 2013/02/26 06:00 CRDT- 2012/08/29 06:00 PHST- 2012/08/29 06:00 [entrez] PHST- 2012/08/29 06:00 [pubmed] PHST- 2013/02/26 06:00 [medline] AID - S2211-5684(12)00263-X [pii] AID - 10.1016/j.diii.2012.07.005 [doi] PST - ppublish SO - Diagn Interv Imaging. 2012 Sep;93(9):711-22. doi: 10.1016/j.diii.2012.07.005. Epub 2012 Aug 25. PMID- 22063963 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20111108 IS - 0309-1740 (Print) IS - 0309-1740 (Linking) VI - 81 IP - 1 DP - 2009 Jan TI - Comparison of acids on the induction of an Acid Tolerance Response in Salmonellatyphimurium, consequences for food safety. PG - 65-70 LID - 10.1016/j.meatsci.2008.06.019 [doi] AB - Salmonellatyphimurium inactivation at pH 3.0 in Brain Heart Infusion (BHI) and Meat Extract (ME) was studied using stationary-phase cells grown in non-acidified BHI (pH 7.4) and ME (pH 6.6) and acidified BHI and ME at pH values of 6.4, 5.4 and 4.5 with acetic, ascorbic, citric, lactic, malic and hydrochloric acids. Cells grown in buffered BHI (pH 7.0) were used as non-acid adapted control cells. Acid adapted S. typhimurium cells obtained in both media (BHI and ME) were more resistant to extremely acidic conditions when ME was used as challenge medium, although the ability of S. typhimurium to survive extreme pH conditions also depended on growth medium and type of acidulant used. Acid adapted cells grown in BHI developed a higher Acid Tolerance Response (ATR) than those grown in ME. When cells were grown in acidified BHI, no bacterial inactivation was observed after three hours of acid challenge in ME. Furthermore, when cells were grown in acidified ME at pH values of 6.4 and 5.4, D-values obtained using ME as challenge medium were, respectively, 6-9 and 10-15 fold higher than those found when BHI was used as challenge medium. In all cases, the order of acids in inducing the ATR was citric>acetic>lactic>malic⩾hydrochloric>ascorbic. These findings represent a concern for food safety as the increase in the acid resistance of acid adapted cells could allow for S. typhimurium survival in the strong acidic environment of the gastrointestinal tract. FAU - Alvarez-Ordóñez, Avelino AU - Alvarez-Ordóñez A AD - Departamento de Higiene y Tecnología de los Alimentos, Facultad de Veterinaria, Universidad de León, 24071 León, Spain. FAU - Fernández, Ana AU - Fernández A FAU - Bernardo, Ana AU - Bernardo A FAU - López, Mercedes AU - López M LA - eng PT - Journal Article DEP - 20080702 PL - England TA - Meat Sci JT - Meat science JID - 101160862 EDAT- 2009/01/01 00:00 MHDA- 2009/01/01 00:01 CRDT- 2011/11/09 06:00 PHST- 2008/04/11 00:00 [received] PHST- 2008/06/18 00:00 [revised] PHST- 2008/06/19 00:00 [accepted] PHST- 2011/11/09 06:00 [entrez] PHST- 2009/01/01 00:00 [pubmed] PHST- 2009/01/01 00:01 [medline] AID - S0309-1740(08)00220-9 [pii] AID - 10.1016/j.meatsci.2008.06.019 [doi] PST - ppublish SO - Meat Sci. 2009 Jan;81(1):65-70. doi: 10.1016/j.meatsci.2008.06.019. Epub 2008 Jul 2. PMID- 19717931 OWN - NLM STAT- MEDLINE DCOM- 20091201 LR - 20151119 IS - 1477-8920 (Print) IS - 1477-8920 (Linking) VI - 7 Suppl 1 DP - 2009 TI - Virulence factor activity relationships for hepatitis E and Cryptosporidium. PG - S55-63 LID - 10.2166/wh.2009.044 [doi] AB - The hepatitis E virus and Cryptosporidium are waterborne pathogens, each consisting of distinct taxa, genotypes and isolates that infect humans, nonhuman animal species or both. Some are associated with disease, others are not. Factors contributing to disease are extremely complicated, possibly involving differences in one or more traits associated with an organism's taxon, genotype or isolate and its infectious dose, and age or condition, as well as the host's physiology and immune status. Potential virulence factors have not yet been identified for HEV. Putative virulence factors for Cryptosporidium might be found in recently recognized genes involved in processes such as excystation, adherence to host cells, invasion, intracellular maintenance and host cell destruction. FAU - Fayer, Ronald AU - Fayer R AD - United States Department of Agriculture, Animal and Natural Resources Institute, Environmental Microbial Safety Laboratory, Beltsville, MD 20705, USA. ronald.fayer@ars.usda.gov FAU - Orlandi, Palmer AU - Orlandi P FAU - Perdue, Michael L AU - Perdue ML LA - eng PT - Journal Article PL - England TA - J Water Health JT - Journal of water and health JID - 101185420 RN - 0 (Biomarkers) RN - 0 (Virulence Factors) SB - IM MH - Animals MH - Biomarkers MH - Cryptosporidium/classification/genetics/*metabolism MH - Gene Expression Regulation/physiology MH - Genotype MH - Hepatitis E virus/*metabolism MH - Humans MH - Virulence Factors/*metabolism MH - *Water Microbiology EDAT- 2009/09/01 06:00 MHDA- 2009/12/16 06:00 CRDT- 2009/09/01 09:00 PHST- 2009/09/01 09:00 [entrez] PHST- 2009/09/01 06:00 [pubmed] PHST- 2009/12/16 06:00 [medline] AID - 10.2166/wh.2009.044 [doi] PST - ppublish SO - J Water Health. 2009;7 Suppl 1:S55-63. doi: 10.2166/wh.2009.044. PMID- 23382446 OWN - NLM STAT- MEDLINE DCOM- 20130503 LR - 20130304 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 131 IP - 3 DP - 2013 Mar TI - Serious air leak syndrome complicating high-flow nasal cannula therapy: a report of 3 cases. PG - e939-44 LID - 10.1542/peds.2011-3767 [doi] AB - Despite the absence of clinical safety data, heated, humidified high-flow nasal cannula (HHFNC) therapy is increasingly being used as an alternative to positive-pressure ventilation in pediatrics. This use of HHFNC is "off label" because the US Food and Drug Administration's approval for these devices was only for air humidification and not as a modality to provide positive distending pressure. For the first time we describe 3 cases who developed serious air leaks related to HHFNC therapy. The first child was a previously healthy 2-month-old male infant with respiratory syncytial virus bronchiolitis who developed a right pneumothorax on day 5 of his illness at 8 liters per minute (lpm). He subsequently required intubation and ventilation for 14 days. The second case involved an otherwise healthy 16-year-old boy with cerebral palsy who developed pneumomediastinum and died of its complications. He was receiving 20 lpm HHFNC therapy when he developed pneumomediastinum. The third case involved a 22-month-old, previously healthy boy who developed subdural hematoma secondary to abuse. He developed a right pneumothorax while receiving HHFNC at a flow of 6 lpm, requiring chest tube placement. These cases emphasize the need for extreme caution while using HHFNC for the off-label indication of providing positive distending pressure in children, especially at flows higher than the patient's minute ventilation. A more detailed study to specifically look at the serious adverse events related to HHFNC is urgently needed. FAU - Hegde, Satyanarayan AU - Hegde S AD - Division of Pediatric Pulmonary Medicine, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. hegdes@ufl.edu FAU - Prodhan, Parthak AU - Prodhan P LA - eng PT - Case Reports PT - Journal Article DEP - 20130204 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM MH - Adolescent MH - Catheters/*adverse effects MH - Humans MH - Infant MH - Male MH - Pneumothorax/*diagnosis/*etiology MH - Positive-Pressure Respiration/*adverse effects/methods MH - Syndrome EDAT- 2013/02/06 06:00 MHDA- 2013/05/04 06:00 CRDT- 2013/02/06 06:00 PHST- 2013/02/06 06:00 [entrez] PHST- 2013/02/06 06:00 [pubmed] PHST- 2013/05/04 06:00 [medline] AID - peds.2011-3767 [pii] AID - 10.1542/peds.2011-3767 [doi] PST - ppublish SO - Pediatrics. 2013 Mar;131(3):e939-44. doi: 10.1542/peds.2011-3767. Epub 2013 Feb 4. PMID- 19817611 OWN - NLM STAT- MEDLINE DCOM- 20091103 LR - 20091012 IS - 1537-6613 (Electronic) IS - 0022-1899 (Linking) VI - 200 Suppl 1 DP - 2009 Nov 1 TI - Assessment of postlicensure safety of rotavirus vaccines, with emphasis on intussusception. PG - S282-90 LID - 10.1086/605051 [doi] AB - The global implementation of rotavirus vaccines will result in a major step toward limiting the disease burden of rotavirus infection. However, as history has shown with the experience of Rotashield (Wyeth Lederle Vaccines), the introduction of a new vaccine should occur in parallel with a postmarketing surveillance strategy to detect any unexpected or rare adverse events. Two new rotavirus vaccines (Rotarix [GSK Biologicals] and RotaTeq [Merck]) have been found to be safe and effective in large clinical trials involving >60,000 infants in the Americas and Europe. However, given that intussusception is an extremely rare event, some risk could be detected as the vaccine is administered to a larger number of infants. In response to a recommendation of the World Health Organization Global Advisory Committee for Vaccine Safety, a standardized approach to the postmarketing surveillance of rotavirus vaccine safety has been developed. We review the principal safety issues requiring further evaluation in postlicensure use of rotavirus vaccines. For intussusception, we also discuss challenges and approaches to monitoring. FAU - Bines, Julie E AU - Bines JE AD - Department of Paediatrics, University of Melbourne, Melbourne, Australia. julie.bines@rch.org.au FAU - Patel, Manish AU - Patel M FAU - Parashar, Umesh AU - Parashar U LA - eng PT - Journal Article PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 RN - 0 (Rotavirus Vaccines) SB - IM MH - Hospitalization/statistics & numerical data MH - Humans MH - Infant MH - Intussusception/*epidemiology/etiology MH - Product Surveillance, Postmarketing MH - Rotavirus Vaccines/*adverse effects MH - Safety EDAT- 2009/10/13 06:00 MHDA- 2009/11/05 06:00 CRDT- 2009/10/13 06:00 PHST- 2009/10/13 06:00 [entrez] PHST- 2009/10/13 06:00 [pubmed] PHST- 2009/11/05 06:00 [medline] AID - 10.1086/605051 [doi] PST - ppublish SO - J Infect Dis. 2009 Nov 1;200 Suppl 1:S282-90. doi: 10.1086/605051. PMID- 11540602 OWN - NASA STAT- MEDLINE DCOM- 19980713 LR - 20191027 IS - 0169-8141 (Print) IS - 0169-8141 (Linking) VI - 19 IP - 5 DP - 1997 May TI - Functional stability limits while holding loads in various positions. PG - 387-95 AB - Stability of the body during manual material handling is an important issue in the prevention of falls and over-exertion injuries. This research investigated stability limits while standing and holding loads in different positions relative to the body. Theoretically, the stability region is the full base of support defined by the perimeter of the foot contact area. However, the functional stability region may be smaller. The purpose of this study was to locate functional stability limits with respect to the base of support. Fifteen male subjects leaned as far as possible in four directions in the sagittal and frontal planes. Their center of gravity location at these extremes determined the stability limit. The results showed that functional stability limits reached only about 60% of the distance to the maximum base of support limits under the conditions of this study. The sway angles reached at the stability limits averaged 9.2 degrees anteroposteriorly and 15.3 degrees laterally. External load positions which lowered the center of gravity of the body-and-load system extended those stability limits. This study provides a postural stability perspective of load-holding which may be applied in establishing safe lifting and reach limits. FAU - Holbein, M A AU - Holbein MA AD - University of Pittsburgh, Department of Industrial Engineering, PA 15261, USA. FAU - Redfern, M S AU - Redfern MS LA - eng PT - Journal Article PL - Netherlands TA - Int J Ind Ergon JT - International journal of industrial ergonomics JID - 8703510 MH - Accident Prevention MH - Accidental Falls/*prevention & control MH - Accidents, Occupational MH - Adolescent MH - Adult MH - Anthropometry MH - Biomechanical Phenomena MH - Body Height MH - Body Weight MH - Ergonomics MH - Humans MH - Male MH - *Postural Balance MH - *Posture MH - *Safety MH - Weight-Bearing OID - NASA: 00021904 EDAT- 1997/05/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1997/05/01 00:00 PHST- 1997/05/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1997/05/01 00:00 [entrez] AID - S0169814196000236 [pii] AID - 10.1016/s0169-8141(96)00023-6 [doi] PST - ppublish SO - Int J Ind Ergon. 1997 May;19(5):387-95. doi: 10.1016/s0169-8141(96)00023-6. PMID- 11481961 OWN - NLM STAT- MEDLINE DCOM- 20010830 LR - 20131121 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 140 IP - 7 DP - 2001 Jul TI - [Hospital-at-home as a solution for the treatment requirements of acute exacerbation in multiple sclerosis]. PG - 603-6, 678 AB - Cooperation between the Multiple Sclerosis center at the Carmel medical center and the Hospital-at-Home (H.H) department of the continuing care unit in the Haifa and Western Galilee district of the Clalit Health Services has made it possible to give methylprednisolone intravenously to Multiple Sclerosis (M.S) patients during an acute exacerbation of the disease, in their home. In this study, we describe the joint work of the two centers. We have summarized 30 treatment courses given to 26 patients in their homes, following referral by the M.S. center, in the year 1999. The aims of the study included assessing satisfaction, safety and cost-effectiveness in a treatment course in the HH framework, as compared to the same treatment being conducted in the framework of hospitalization in various neurological departments, as was done in the past in the same group of patients. The expenses involved in HH for this group of patients were only 14% of the parallel treatment in the hospital (a savings of 86%). The treatment has proven to be extremely safe. There were no side-effects that required returning patients to the hospital, and the treatment was given in conditions of maximum comfort for the patient and his family. A telephone survey was conducted, which compared the satisfaction with the HH treatment, and the burden caused the patient's family to prior hospitalization for the same treatment. For all of the parameters examined, greater satisfaction was distinctly proven in the HH treatment. In light of these findings, we can conclude that giving methylprednisolone intravenously to M.S patients during an acute exacerbation, in the HH framework, is a safe and cost effective treatment, preferred by the patient and his family. FAU - Steinmetz, D AU - Steinmetz D AD - Hospital-at-Home Department, Continuing Care Unit, Clalit Health Services, Haifa and Western Galilee District, Haifa, Israel. FAU - Edelstein, H AU - Edelstein H FAU - Dishon, S AU - Dishon S FAU - Berkovitz, E AU - Berkovitz E FAU - Almany, A AU - Almany A FAU - Miller, A AU - Miller A LA - heb PT - English Abstract PT - Journal Article PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 RN - X4W7ZR7023 (Methylprednisolone) SB - IM MH - Caregivers/psychology MH - Continuity of Patient Care/economics/*organization & administration MH - Cost-Benefit Analysis MH - Disease Progression MH - Family MH - Home Care Services/economics/*organization & administration MH - Humans MH - Injections, Intravenous MH - Israel MH - Methylprednisolone/administration & dosage/*therapeutic use MH - Multiple Sclerosis/drug therapy/*physiopathology/*therapy MH - Patient Satisfaction MH - Safety EDAT- 2001/08/03 10:00 MHDA- 2001/08/31 10:01 CRDT- 2001/08/03 10:00 PHST- 2001/08/03 10:00 [pubmed] PHST- 2001/08/31 10:01 [medline] PHST- 2001/08/03 10:00 [entrez] PST - ppublish SO - Harefuah. 2001 Jul;140(7):603-6, 678. PMID- 35541358 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2046-2069 (Electronic) IS - 2046-2069 (Linking) VI - 8 IP - 27 DP - 2018 Apr 18 TI - High-throughput metabolomics enables metabolite biomarkers and metabolic mechanism discovery of fish in response to alkalinity stress. PG - 14983-14990 LID - 10.1039/c8ra01317a [doi] AB - High throughput mass spectrometry (MS)-based metabolomics is a popular platform for small molecule metabolites analyses that are widely used for detecting biomarkers in the research field of environmental assessment. Crucian carp (Carassius carassius, CC) is an economically and ecologically important fish in Asia. It can adapt to extremely high alkalinity, providing us with valuable material to understand the adaptation mechanism for extreme environmental stress. However, the information on the metabolite biomarkers and metabolic mechanisms of CC exposed to alkaline stress is not entirely clear. We applied high-throughput UPLC-Q-TOF/MS combined with chemometrics to identify changes in the metabolome of CC exposed to different concentrations of alkalinity for long term effects. Metabolic differences among alkalinity-treated groups were identified by multivariate statistical analysis. Further, 7 differential metabolites were found after exposure to alkaline conditions. In total, 23 metabolic pathways of these differential metabolites were significantly affected. Alkalinity exposure resulted in widespread change in metabolic profiles in the plasma with disruptions in the phenylalanine metabolism, glycine, serine and threonine metabolism, pyruvate metabolism, tyrosine metabolism, etc. The integrated pathway analysis of the associated metabolites showed that tRNA charging, l-cysteine degradation II, superpathway of methionine degradation, l-serine degradation, tyrosine biosynthesis IV, etc. appear to be the most significantly represented functional categories. Overall, this study demonstrated that metabolic changes in CC played a role in adaptation to the highly alkaline environmental stress. CI - This journal is © The Royal Society of Chemistry. FAU - Sun, Yan-Chun AU - Sun YC AUID- ORCID: 0000-0002-8204-4706 AD - Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences/Laboratory of Quality & Safety Risk Assessment for Aquatic Products (Harbin), Ministry of Agriculture Harbin 150070 China Sunyc2004@163.com +86-0451-84604803 +86-0451-84861316. FAU - Wu, Song AU - Wu S AD - Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences/Laboratory of Quality & Safety Risk Assessment for Aquatic Products (Harbin), Ministry of Agriculture Harbin 150070 China Sunyc2004@163.com +86-0451-84604803 +86-0451-84861316. FAU - Du, Ning-Ning AU - Du NN AD - Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences/Laboratory of Quality & Safety Risk Assessment for Aquatic Products (Harbin), Ministry of Agriculture Harbin 150070 China Sunyc2004@163.com +86-0451-84604803 +86-0451-84861316. FAU - Song, Yi AU - Song Y AD - Chinese Academy of Fishery Sciences Beijing 100141 P. R. China. FAU - Xu, Wei AU - Xu W AD - Heilongjiang River Fisheries Research Institute of Chinese Academy of Fishery Sciences/Laboratory of Quality & Safety Risk Assessment for Aquatic Products (Harbin), Ministry of Agriculture Harbin 150070 China Sunyc2004@163.com +86-0451-84604803 +86-0451-84861316. LA - eng PT - Journal Article DEP - 20180419 PL - England TA - RSC Adv JT - RSC advances JID - 101581657 PMC - PMC9079986 COIS- The authors declare no competing financial interests. EDAT- 2018/04/19 00:00 MHDA- 2018/04/19 00:01 PMCR- 2018/04/19 CRDT- 2022/05/11 04:01 PHST- 2018/02/10 00:00 [received] PHST- 2018/04/04 00:00 [accepted] PHST- 2022/05/11 04:01 [entrez] PHST- 2018/04/19 00:00 [pubmed] PHST- 2018/04/19 00:01 [medline] PHST- 2018/04/19 00:00 [pmc-release] AID - c8ra01317a [pii] AID - 10.1039/c8ra01317a [doi] PST - epublish SO - RSC Adv. 2018 Apr 19;8(27):14983-14990. doi: 10.1039/c8ra01317a. eCollection 2018 Apr 18. PMID- 28854130 OWN - NLM STAT- MEDLINE DCOM- 20171204 LR - 20220321 IS - 1087-0415 (Electronic) IS - 1081-0730 (Linking) VI - 22 IP - sup1 DP - 2017 TI - Facilitators and Barriers to Community Acceptance of Safe, Dignified Medical Burials in the Context of an Ebola Epidemic, Sierra Leone, 2014. PG - 24-30 LID - 10.1080/10810730.2016.1209601 [doi] AB - Sierra Leone was heavily affected by the Ebola epidemic, with over 14,000 total cases. Given that corpses of people who have died from Ebola are highly infectious and given the extremely high risk of Ebola transmission associated with direct contact with bodies of people who have died of Ebola, community acceptance of safe, dignified medical burials was one of the important components of efforts to stop the Ebola epidemic in Sierra Leone. Information on barriers and facilitators for community acceptance of safe, dignified medical burials is limited. A rapid qualitative assessment using focus group discussions (FGDs) explored community knowledge, attitudes, and practices towards safe and dignified burials in seven chiefdoms in Bo District, Sierra Leone. In total, 63 FGDs were conducted among three groups: women >25 years of age, men >25 years of age, and young adults 19-25 years of age. In addition to concerns about breaking cultural traditions, barriers to safe burial acceptance included concerns by family members about being able to view the burial, perceptions that bodies were improperly handled, and fear that stigma may occur if a family member receives a safe, dignified medical burial. Participants suggested that providing opportunities for community members to participate in safe and dignified burials would improve community acceptance. FAU - Lee-Kwan, Seung Hee AU - Lee-Kwan SH AD - a Epidemic Intelligence Service , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. AD - b Division of Nutrition, Physical Activity, and Obesity, National Center for Chronic Disease Prevention and Health Promotion , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - DeLuca, Nickolas AU - DeLuca N AD - c Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Bunnell, Rebecca AU - Bunnell R AD - d Division of Global Health Protection, Center for Global Health , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Clayton, Heather B AU - Clayton HB AD - e Division of Adolescent and School Health, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention , Centers for Disease Control and Prevention , Atlanta , Georgia , USA. FAU - Turay, Alhaji Sayui AU - Turay AS AD - f Bo District Health Management Team , Sierra Leone Ministry of Health and Sanitation , Bo , Sierra Leone. FAU - Mansaray, Yayah AU - Mansaray Y AD - g Bo Social Mobilization Team , Bo , Sierra Leone. LA - eng PT - Journal Article PL - United States TA - J Health Commun JT - Journal of health communication JID - 9604100 MH - Adult MH - Burial/*methods MH - Community Participation/*psychology MH - Cultural Characteristics MH - Epidemics/*prevention & control MH - Female MH - Focus Groups MH - Health Knowledge, Attitudes, Practice MH - Hemorrhagic Fever, Ebola/epidemiology/*prevention & control/psychology MH - Humans MH - Male MH - *Safety MH - Sierra Leone/epidemiology MH - Social Stigma MH - Young Adult EDAT- 2017/08/31 06:00 MHDA- 2017/12/05 06:00 CRDT- 2017/08/31 06:00 PHST- 2017/08/31 06:00 [entrez] PHST- 2017/08/31 06:00 [pubmed] PHST- 2017/12/05 06:00 [medline] AID - 10.1080/10810730.2016.1209601 [doi] PST - ppublish SO - J Health Commun. 2017;22(sup1):24-30. doi: 10.1080/10810730.2016.1209601. PMID- 24219568 OWN - NLM STAT- MEDLINE DCOM- 20141215 LR - 20181202 IS - 1460-9592 (Electronic) IS - 1155-5645 (Linking) VI - 24 IP - 5 DP - 2014 May TI - Management of mediastinal syndromes in pediatrics: a new challenge of ultrasound guidance to avoid high-risk general anesthesia. PG - 534-7 LID - 10.1111/pan.12300 [doi] AB - Adverse events associated with anesthetic management of anterior mediastinal masses in pediatrics are common. To avoid an extremely hazardous general anesthesia, the use of real-time ultrasonography offers an effective alternative in high-risk cases. We report the anesthetic management including a light sedation and ultrasound guidance for regional anesthesia, surgical node biopsy, and placement of a central venous line in two children with an anterior symptomatic mediastinal mass. For pediatric patients with clinical and/or radiologic signs of airway compression, ultrasound guidance provides safety technical assistance to avoid general anesthesia and should be performed for the initial diagnostic and therapeutic procedures. CI - © 2013 John Wiley & Sons Ltd. FAU - Sola, Chrystelle AU - Sola C AD - Department of Anesthesia and Critical Care Medicine, Lapeyronie University Hospital, Montpellier, France. FAU - Choquet, Olivier AU - Choquet O FAU - Prodhomme, Olivier AU - Prodhomme O FAU - Capdevila, Xavier AU - Capdevila X FAU - Dadure, Christophe AU - Dadure C LA - eng PT - Case Reports PT - Journal Article DEP - 20131113 PL - France TA - Paediatr Anaesth JT - Paediatric anaesthesia JID - 9206575 RN - 0 (Amides) RN - 0 (Anesthetics, Local) RN - 7IO5LYA57N (Ropivacaine) SB - IM MH - Adolescent MH - Amides/administration & dosage MH - *Anesthesia, General MH - Anesthetics, Local/*administration & dosage MH - Catheterization, Central Venous/methods MH - Cervical Plexus/*diagnostic imaging MH - Cervical Plexus Block/*methods MH - Child MH - Humans MH - Male MH - Mediastinal Diseases/*surgery MH - Risk MH - Ropivacaine MH - Sentinel Lymph Node Biopsy/methods MH - Syndrome MH - Ultrasonography, Interventional/*methods OTO - NOTNLM OT - mediastinal syndromes OT - pediatrics anesthesia OT - regional anesthesia OT - ultrasound guidance EDAT- 2013/11/14 06:00 MHDA- 2014/12/17 06:00 CRDT- 2013/11/14 06:00 PHST- 2013/09/25 00:00 [accepted] PHST- 2013/11/14 06:00 [entrez] PHST- 2013/11/14 06:00 [pubmed] PHST- 2014/12/17 06:00 [medline] AID - 10.1111/pan.12300 [doi] PST - ppublish SO - Paediatr Anaesth. 2014 May;24(5):534-7. doi: 10.1111/pan.12300. Epub 2013 Nov 13. PMID- 8001711 OWN - NLM STAT- MEDLINE DCOM- 19950125 LR - 20121115 IS - 0338-1684 (Print) IS - 0338-1684 (Linking) VI - 20 IP - 2 Pt 2 DP - 1994 TI - [Is a gene therapy for diabetic syndromes foreseeable?]. PG - 240-50 AB - The concepts and methods of gene therapy are summarized in order to assess a possible implication in the treatment of diabetes mellitus. Gene therapy requires identification of the critical genetic defect and then the preparation and introduction of the therapeutic transgene, with an appropriate targeting and a strong regulated expression. The bases of the different human diabetic syndromes are reviewed in their present state of knowledge: they are mostly clarified in the case of MODY, extreme insulin resistance syndromes, and some mitochondrial diabetic syndromes; but still obscure in the case of Type 2 and Type 1 diabetic syndromes. Substantial contributions to the understanding of the pathophysiology of diabetes have been brought by transgenic animal models. Gene therapy of human diabetic syndromes may become available, in an undetermined future, particularly under the forms of insulin secreting transgenic "organoïds". Such treatments should be proportionate to the intrinsic severity of the candidate diseases and carefully screened for safety. FAU - Assan, R AU - Assan R AD - Service de Diabétologie, Hôpital Bichat, Paris. FAU - Clauser, E AU - Clauser E FAU - Larger, E AU - Larger E LA - fre PT - English Abstract PT - Journal Article PT - Review TT - Une thérapie génique des syndromes diabétiques est-elle envisageable? PL - France TA - Diabete Metab JT - Diabete & metabolisme JID - 7604157 SB - IM MH - Animals MH - Animals, Genetically Modified MH - Diabetes Mellitus/*therapy MH - Diabetes Mellitus, Experimental/*therapy MH - Disease Models, Animal MH - Forecasting MH - Genetic Therapy/methods/*trends MH - Humans MH - Syndrome RF - 48 EDAT- 1994/01/01 00:00 MHDA- 2000/03/11 09:00 CRDT- 1994/01/01 00:00 PHST- 1994/01/01 00:00 [pubmed] PHST- 2000/03/11 09:00 [medline] PHST- 1994/01/01 00:00 [entrez] PST - ppublish SO - Diabete Metab. 1994;20(2 Pt 2):240-50. PMID- 11174768 OWN - NLM STAT- MEDLINE DCOM- 20020212 LR - 20191210 IS - 1075-4210 (Print) IS - 1075-4210 (Linking) VI - 7 IP - 1 DP - 2001 Jan-Mar TI - Preventing injuries associated with extreme cold. PG - 26-30 CN - Centers for Disease Control and Prevention LA - eng PT - Journal Article PL - United States TA - Int J Trauma Nurs JT - International journal of trauma nursing JID - 9506955 MH - Adult MH - Centers for Disease Control and Prevention, U.S. MH - Cold Temperature/adverse effects MH - Electricity MH - Emergencies MH - Fires/prevention & control MH - Food Supply/standards MH - Frostbite/*complications/*prevention & control MH - Heating/methods/standards MH - Humans MH - Hypothermia/*complications/*prevention & control MH - Practice Guidelines as Topic MH - Safety Management/*methods MH - United States MH - Water Supply/standards MH - Weather EDAT- 2001/02/15 11:00 MHDA- 2002/02/13 10:01 CRDT- 2001/02/15 11:00 PHST- 2001/02/15 11:00 [pubmed] PHST- 2002/02/13 10:01 [medline] PHST- 2001/02/15 11:00 [entrez] AID - S1075421001317777 [pii] AID - 10.1067/mtn.2001.112376 [doi] PST - ppublish SO - Int J Trauma Nurs. 2001 Jan-Mar;7(1):26-30. doi: 10.1067/mtn.2001.112376. PMID- 12535911 OWN - NLM STAT- MEDLINE DCOM- 20030403 LR - 20191106 IS - 0022-4375 (Print) IS - 0022-4375 (Linking) VI - 34 IP - 1 DP - 2003 Jan TI - How well do parents manage young driver crash risks? PG - 91-7 AB - Motor vehicle crashes are extremely high among young drivers during at least the first year of licensure. Crash risks decline with increased experience, but the more newly licensed teenagers drive, the greater their risk exposure. Hence, the dilemma facing policy makers and parents is how to provide young drivers with driving experience without unduly increasing their crash risk. Graduated driver licensing policies serve to delay licensure and then limit exposure to the highest risk conditions after licensure, allowing young drivers to gain experience only under less risky driving conditions. A similar strategy is needed to guide parents. Parents do not appear to appreciate just how risky driving is for novice drivers and tend to exert less control over their teenage children's driving than might be expected. Recent research has demonstrated that simple motivational strategies can persuade parents to adopt driving agreements and impose greater restrictions on early teen driving. FAU - Simons-Morton, Bruce G AU - Simons-Morton BG AD - Prevention Research Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Boulevard, 7B05, Bethesda, MD 20892-7510, USA. mortonb@mail.nih.gov FAU - Hartos, Jessica L AU - Hartos JL LA - eng PT - Journal Article PL - United States TA - J Safety Res JT - Journal of safety research JID - 1264241 SB - IM MH - Accidents, Traffic/prevention & control MH - Adolescent MH - Adult MH - Attitude MH - Automobile Driving/*education MH - Connecticut MH - Humans MH - Licensure/legislation & jurisprudence MH - Maryland MH - *Parenting MH - Persuasive Communication MH - *Risk Reduction Behavior MH - Safety Management MH - United States EDAT- 2003/01/22 04:00 MHDA- 2003/04/04 05:00 CRDT- 2003/01/22 04:00 PHST- 2003/01/22 04:00 [pubmed] PHST- 2003/04/04 05:00 [medline] PHST- 2003/01/22 04:00 [entrez] AID - S0022437502000853 [pii] AID - 10.1016/s0022-4375(02)00085-3 [doi] PST - ppublish SO - J Safety Res. 2003 Jan;34(1):91-7. doi: 10.1016/s0022-4375(02)00085-3. PMID- 9199907 OWN - NLM STAT- MEDLINE DCOM- 19970813 LR - 20190722 IS - 0016-5107 (Print) IS - 0016-5107 (Linking) VI - 45 IP - 6 DP - 1997 Jun TI - Current induction in a fiberglass guidewire compared to conventional wires during simulated papillotomy. PG - 493-7 AB - BACKGROUND: Current induced in a guidewire during papillotomy poses a danger of injury to the bile duct. We measured currents induced in three commercially available guidewires and a prototype fiberglass wire during simulated sphincterotomy under standard and nonstandard conditions. METHODS: Blended current at 55 W was applied to a double-lumen papillotome grounded through a 1000 omega resistor. For extreme conditions, power was increased to 70 W using a single-lumen papillotome. Fault conditions were created with a break in the insulation at the distal end of each wire. Guidewire-induced current was measured, and safety calculations performed for adherence to accepted standards for electrosurgical devices. RESULTS: Induced current was within safety limits for all wires tested under standard conditions. With insulation faults, one of the commercially available wires was unsafe. Under extreme conditions, with or without faults, the three commercial wires produced currents ranging from 9% to 225% above acceptable levels, while only the prototype wire remained safe. CONCLUSIONS: Most guidewires contain metal cores that function as capacitors. Because its core is primarily fiberglass, the prototype wire generates less induced current under nonstandard conditions, thus achieving a greater margin of safety during wire-guided sphincterotomy. FAU - O'Brien, J W AU - O'Brien JW AD - Department of Medicine, Tufts University, School of Medicine, Boston, Massachusetts, USA. FAU - Chen, S L AU - Chen SL FAU - Connolly, R AU - Connolly R FAU - Libby, E D AU - Libby ED LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Gastrointest Endosc JT - Gastrointestinal endoscopy JID - 0010505 RN - 0 (fiberglass) SB - IM MH - Bile Ducts/*surgery MH - Duodenoscopes MH - Duodenoscopy/methods MH - Glass MH - Humans MH - *Models, Anatomic MH - Safety MH - Sphincterotomy, Endoscopic/*instrumentation EDAT- 1997/06/01 00:00 MHDA- 1997/06/01 00:01 CRDT- 1997/06/01 00:00 PHST- 1997/06/01 00:00 [pubmed] PHST- 1997/06/01 00:01 [medline] PHST- 1997/06/01 00:00 [entrez] AID - S0016-5107(97)70200-1 [pii] AID - 10.1016/s0016-5107(97)70200-1 [doi] PST - ppublish SO - Gastrointest Endosc. 1997 Jun;45(6):493-7. doi: 10.1016/s0016-5107(97)70200-1. PMID- 16918119 OWN - NLM STAT- MEDLINE DCOM- 20060928 LR - 20220330 IS - 0094-6354 (Print) IS - 0094-6354 (Linking) VI - 74 IP - 4 DP - 2006 Aug TI - Airway management: a patient with Madelung disease. PG - 281-4 AB - This case study describes a 51-year-old, ASA physical status II Hispanic man who underwent liposuction to the anterior neck and resection of adipose tissue of the posterior neck. The patient was diagnosed with multiple symmetric lipomatosis, better known by its eponym, Madelung disease. This disease is characterized by abnormal adipose tissue growth primarily in the neck and shoulder regions. As a result of this pathology, a complete airway assessment was challenging. The patient's Mallampati classification was class III with visualization of the soft palate only. Other elements of a full assessment such as thyromental distance, sternomental distance, and tracheal orientation were impossible to evaluate because of the extreme circumferential girth of the adipose tissue in the neck. In addition, flexion and extension of the neck was limited by a minimum of 20 degrees because of the pathology. The patient was deemed as having a difficult airway, and an awake fiberoptic intubation was planned and used successfully. The subsequent surgical procedure progressed without incident, and the patient was transferred to a stepdown unit for monitoring of his airway postoperatively. FAU - Conroy, Jeffrey P AU - Conroy JP AD - US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Tex, USA. jeffrey.conroy@us.army.mil LA - eng PT - Case Reports PT - Journal Article PL - United States TA - AANA J JT - AANA journal JID - 0431420 MH - Airway Obstruction/classification/diagnosis/etiology/*therapy MH - Anesthesia, General/*methods/nursing MH - Causality MH - Humans MH - Intraoperative Care/methods/nursing MH - Intubation, Intratracheal/methods/nursing MH - Laryngoscopy MH - Lipectomy/methods/nursing MH - Lipomatosis, Multiple Symmetrical/complications/*surgery MH - Male MH - Middle Aged MH - Nerve Block/methods/nursing MH - *Nurse Anesthetists MH - Nursing Assessment MH - Patient Care Planning MH - Safety Management MH - Severity of Illness Index EDAT- 2006/08/22 09:00 MHDA- 2006/09/29 09:00 CRDT- 2006/08/22 09:00 PHST- 2006/08/22 09:00 [pubmed] PHST- 2006/09/29 09:00 [medline] PHST- 2006/08/22 09:00 [entrez] PST - ppublish SO - AANA J. 2006 Aug;74(4):281-4. PMID- 22490754 OWN - NLM STAT- MEDLINE DCOM- 20130314 LR - 20140226 IS - 0578-1426 (Print) IS - 0578-1426 (Linking) VI - 51 IP - 1 DP - 2012 Jan TI - [A clinical analysis of reninoma-induced hypertensive crisis associated with reversible posterior encephalopathy syndrome]. PG - 24-7 AB - OBJECTIVE: Reninoma is a rare benign tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin, while it is extremely rare that reninoma induced hypertensive crisis with reversible posterior encephalopathy syndrome (RPES). To improve the clinical understanding for this disease, we conducted a case-analysis. METHODS: To analyze the clinical and pathological data of a case of reninoma-induced hypertensive crisis with reversible posterior encephalopathy syndrome, who was admitted to Peking University First Hospital in November, 2007 and follow-up. RESULTS: This was a 16-year old female patient, onset with suddenly spasm with loss of consciousness, while blood pressure stepped up to 210/140 mm Hg (1 mm Hg = 0.133 kPa), and the head magnetic resonance imaging (MRI) revealed "multiple long-T(2) signal", and hypokalemia (2.8 - 3.2 mmol/L), urine protein positive, ultrasound cardiogram revealed left ventricular hypertrophy, laboratory study revealed hyperreninism (38.23 ng·ml(-1)×h(-1), normal range 0.07 - 1.15 ng·ml(-1)×h(-1)) and hyperaldosteronism (660.9 ng/L, normal range 60 - 174 ng/L), abdominal CT-Scan revealed a mass at right kidney, blood pressure achieved safety range and the head MRI was rechecked and revealed "the abnormal long-T(2) signal disappeared". The clinical diagnosis was reninoma induced hypertensive crisis with RPES. The tumor was resected and the pathologic diagnosis was reninoma. The patient remained normotensive in the postoperative period without any medication. CONCLUSIONS: Reninoma represents a rare but surgically curable cause of hypertension, thus the clinical suspicion of it is very important in young patients. If the diagnosis is confirmed, positive treatment must be done immediately to improve the prognosis. The most common cause of RPES is hypertension, and the diagnosis depends on the distinctive head MRI. There is always a good prognosis with the decline of blood pressure rapidly. FAU - Wu, Hong-hua AU - Wu HH AD - Department of Endocrinology, Peking University First Hospital, Beijing, China. FAU - Wang, Guang-ya AU - Wang GY FAU - Ma, Xiao-wei AU - Ma XW FAU - Guo, Xiao-hui AU - Guo XH LA - chi PT - Case Reports PT - English Abstract PT - Journal Article PL - China TA - Zhonghua Nei Ke Za Zhi JT - Zhonghua nei ke za zhi JID - 16210490R SB - IM MH - Adolescent MH - Female MH - Humans MH - Hyperaldosteronism/etiology MH - Hypertension/*etiology MH - Hypertensive Encephalopathy/*etiology MH - Kidney Neoplasms/*complications/physiopathology MH - Syndrome EDAT- 2012/04/12 06:00 MHDA- 2013/03/15 06:00 CRDT- 2012/04/12 06:00 PHST- 2012/04/12 06:00 [entrez] PHST- 2012/04/12 06:00 [pubmed] PHST- 2013/03/15 06:00 [medline] PST - ppublish SO - Zhonghua Nei Ke Za Zhi. 2012 Jan;51(1):24-7. PMID- 11538979 OWN - NASA STAT- MEDLINE DCOM- 19961011 LR - 20190915 IS - 0273-1177 (Print) IS - 0273-1177 (Linking) VI - 18 IP - 1-2 DP - 1996 TI - A consensus approach to planetary protection requirements: recommendations for Mars lander missions. PG - 317-21 AB - Over the last several years, the nature of the surface conditions on the planet Mars, our knowledge of the growth capabilities of Earth organisms under extreme conditions, and future opportunities for Mars exploration have been under extensive review in the United States and elsewhere. As part of these examinations, in 1992 the US Space Studies Board made a series of recommendations to NASA on the requirements that should be implemented on future missions that will explore Mars. In particular, significant changes were recommended in the requirements for Mars landers, changes that significantly alleviated the burden of planetary protection implementation for these missions. In this paper we propose a resolution implementing this new set of recommendations, for adoption by COSPAR at its 30th meeting in Hamburg. We also discuss future directions and study areas for planetary protection, in light of changing plans for Mars exploration. FAU - Rummel, J D AU - Rummel JD AD - Marine Biological Laboratory, Woods Hole, MA 02543, USA. FAU - Meyer, M A AU - Meyer MA LA - eng PT - Journal Article PL - England TA - Adv Space Res JT - Advances in space research : the official journal of the Committee on Space Research (COSPAR) JID - 9878935 MH - Consensus Development Conferences as Topic MH - Containment of Biohazards/*standards/trends MH - Environmental Pollution/prevention & control MH - Exobiology MH - *Extraterrestrial Environment MH - International Agencies MH - International Cooperation MH - *Mars MH - Planets MH - Public Policy MH - Space Flight/*standards MH - Spacecraft/standards MH - Sterilization/*standards OID - NASA: 00019435 OTO - NASA OT - NASA Center HQS OT - NASA Discipline Exobiology OT - NASA Discipline Number 99-99 OT - NASA Program Life Sciences Management FIR - Meyer, M A IR - Meyer MA IRAD- HQS EDAT- 1996/01/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1996/01/01 00:00 PHST- 1996/01/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1996/01/01 00:00 [entrez] AID - 10.1016/0273-1177(95)00822-v [doi] PST - ppublish SO - Adv Space Res. 1996;18(1-2):317-21. doi: 10.1016/0273-1177(95)00822-v. PMID- 3952042 OWN - NLM STAT- MEDLINE DCOM- 19860411 LR - 20190713 IS - 0032-5481 (Print) IS - 0032-5481 (Linking) VI - 79 IP - 4 DP - 1986 Mar TI - Hepatitis in clinical practice. 1. Hepatitis A and B. PG - 194-200, 209-14 AB - As is evident from the foregoing discussion, hepatitis A and hepatitis B are not static, passé disease. Knowledge concerning these illnesses continues to expand at a fantastic rate--all of it of extreme practical clinical significance. Most interesting is the elucidation of the etiology of the acquired immune deficiency syndrome (AIDS) and the increase this knowledge is hoped to produce on the utilization of hepatitis B vaccine. Also extremely important is the development of recombinant DNA vaccine, which will permit total circumvention of the question of AIDS and safety of the hepatitis B vaccine. FAU - Sarver, D K AU - Sarver DK LA - eng PT - Journal Article PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 RN - 0 (DNA, Recombinant) RN - 0 (Viral Hepatitis Vaccines) SB - IM MH - Acquired Immunodeficiency Syndrome/prevention & control MH - Adult MH - Child MH - Child, Preschool MH - DNA, Recombinant MH - Developing Countries MH - Hepatitis A/diagnosis/*epidemiology/prevention & control MH - Hepatitis B/diagnosis/*epidemiology/prevention & control MH - Humans MH - Infant MH - United States MH - Viral Hepatitis Vaccines/isolation & purification/therapeutic use EDAT- 1986/03/01 00:00 MHDA- 1986/03/01 00:01 CRDT- 1986/03/01 00:00 PHST- 1986/03/01 00:00 [pubmed] PHST- 1986/03/01 00:01 [medline] PHST- 1986/03/01 00:00 [entrez] AID - 10.1080/00325481.1986.11699324 [doi] PST - ppublish SO - Postgrad Med. 1986 Mar;79(4):194-200, 209-14. doi: 10.1080/00325481.1986.11699324. PMID- 22269514 OWN - NLM STAT- MEDLINE DCOM- 20120531 LR - 20120124 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 45 DP - 2012 Mar TI - Fuzzy-logic-based network for complex systems risk assessment: application to ship performance analysis. PG - 305-16 LID - 10.1016/j.aap.2011.07.017 [doi] AB - In this paper, a new interpretation of intuitionistic fuzzy sets in the advanced framework of the Dempster-Shafer theory of evidence is extended to monitor safety-critical systems' performance. Not only is the proposed approach more effective, but it also takes into account the fuzzy rules that deal with imperfect knowledge/information and, therefore, is different from the classical Takagi-Sugeno fuzzy system, which assumes that the rule (the knowledge) is perfect. We provide an analytical solution to the practical and important problem of the conceptual probabilistic approach for formal ship safety assessment using the fuzzy set theory that involves uncertainties associated with the reliability input data. Thus, the overall safety of the ship engine is investigated as an object of risk analysis using the fuzzy mapping structure, which considers uncertainty and partial truth in the input-output mapping. The proposed method integrates direct evidence of the frame of discernment and is demonstrated through references to examples where fuzzy set models are informative. These simple applications illustrate how to assess the conflict of sensor information fusion for a sufficient cooling power system of vessels under extreme operation conditions. It was found that propulsion engine safety systems are not only a function of many environmental and operation profiles but are also dynamic and complex. CI - Copyright © 2011 Elsevier Ltd. All rights reserved. FAU - Abou, Seraphin C AU - Abou SC AD - Mechanical and Industrial Engineering Department, University of Minnesota Duluth, 1305 Ordean Court, Duluth, MN 55812, USA. sabou@d.umn.edu LA - eng PT - Journal Article DEP - 20110919 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accident Prevention/*standards/*statistics & numerical data MH - Decision Support Techniques MH - Engineering/methods/standards MH - *Fuzzy Logic MH - Humans MH - Risk Assessment/*statistics & numerical data MH - Safety/*standards/*statistics & numerical data MH - Ships/*standards/*statistics & numerical data EDAT- 2012/01/25 06:00 MHDA- 2012/06/01 06:00 CRDT- 2012/01/25 06:00 PHST- 2011/03/07 00:00 [received] PHST- 2011/07/21 00:00 [revised] PHST- 2011/07/24 00:00 [accepted] PHST- 2012/01/25 06:00 [entrez] PHST- 2012/01/25 06:00 [pubmed] PHST- 2012/06/01 06:00 [medline] AID - S0001-4575(11)00214-4 [pii] AID - 10.1016/j.aap.2011.07.017 [doi] PST - ppublish SO - Accid Anal Prev. 2012 Mar;45:305-16. doi: 10.1016/j.aap.2011.07.017. Epub 2011 Sep 19. PMID- 14631907 OWN - NLM STAT- MEDLINE DCOM- 20040106 LR - 20191210 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 142 IP - 11 DP - 2003 Nov TI - [Optimal fluoride level in drinking water and public health]. PG - 754-8, 806 AB - Water fluoridation is a safe, efficient, and well-proven way of preventing dental decay in the community. In countries such as Israel, where dental care is not covered by the national insurance law, this has an important role in reducing social inequalities in health care. For toddlers and children, water fluoridation is the only way of promoting dental health without a need for regular visits to dental clinics, and without regard to parent awareness and motivation. The other methods of fluoride supplementation do not succeed in reaching the level of safety and cost-efficiency of water fluoridation, and their use is successful only among upper socio-economic classes. Water fluoridation has been defined by the US CDC as one of the main achievements in health care during the 20th century. In spite of the legal difficulties raised by various activist groups, the use of water fluoridation is growing steadily among developed as well as third world countries. The Israeli bylaw of national water fluoridation that is in effect will enable the safe improvement of the overall dental health status of the population at an extremely low cost. FAU - Karsenty, E AU - Karsenty E AD - Environmental Epidemiology Unit, Israeli Ministry of Health, Public Health Services, Israeli Ministry of Health, Jerusalem. FAU - Sgan-Cohen, H AU - Sgan-Cohen H FAU - Vered, Y AU - Vered Y FAU - Leventhal, A AU - Leventhal A LA - heb PT - Journal Article PT - Review PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 RN - Q80VPU408O (Fluorides) SB - IM MH - Centers for Disease Control and Prevention, U.S. MH - Child MH - Child, Preschool MH - Dental Caries/prevention & control MH - Fluoridation/*methods/standards MH - Fluorides/*analysis MH - Health Promotion MH - Humans MH - Infant MH - *Public Health MH - Safety MH - United States MH - Water Supply/standards RF - 38 EDAT- 2003/11/25 05:00 MHDA- 2004/01/07 05:00 CRDT- 2003/11/25 05:00 PHST- 2003/11/25 05:00 [pubmed] PHST- 2004/01/07 05:00 [medline] PHST- 2003/11/25 05:00 [entrez] PST - ppublish SO - Harefuah. 2003 Nov;142(11):754-8, 806. PMID- 9669057 OWN - NLM STAT- MEDLINE DCOM- 19980928 LR - 20200225 IS - 0160-9289 (Print) IS - 1932-8737 (Electronic) IS - 0160-9289 (Linking) VI - 21 IP - 7 DP - 1998 Jul TI - Additional antianginal and anti-ischemic efficacy of mibefradil in patients concomitantly treated with long-acting nitrates for chronic stable angina pectoris. PG - 483-90 AB - BACKGROUND: Mibefradil, a newly approved antihypertensive and antianginal drug, is the first member of a new class of calcium antagonists (CAs), the tetralol derivatives, that selectively blocks T-type Ca2+ channels in contrast to classical CAs which, at therapeutic concentrations, block only L-type Ca2+ channels. Since patients with chronic stable angina pectoris typically may be treated with the combination of a long-acting nitrate and a CA, the additive efficacy and safety of mibefradil in combination with nitrate therapy needs to be determined. HYPOTHESIS: This study was designed to assess the efficacy, tolerability, and safety of mibefradil when added to long-acting nitrate therapy in patients with chronic stable angina pectoris. METHODS: Following a 1-week placebo run-in period, patients were randomized to receive either mibefradil 50 mg (n = 96) or placebo (n = 93) once daily in addition to their nitrate therapy. After 2 weeks of active treatment, patients receiving the mibefradil were force titrated to 150 mg once daily for an additional 2 weeks. Exercise tolerance tests (ETTs) were performed at the end of Weeks 2 and 4; patients also maintained an anginal diary during the 4-week treatment period. RESULTS: After 2 weeks of treatment with 50 mg mibefradil (within the current recommended dose range), a statistically significant but modest increase in total exercise duration was observed (treatment effect 16.4 s, p = 0.04). Similarly, there was a significant increase in time to onset of ischemia (treatment effect 26 s, p = 0.008). The adverse event profile of the 50 mg dose was indistinguishable from placebo, indicating that this dose was extremely well tolerated. At Week 4, the mibefradil-treated patients were taking 150 mg, which is above the current recommended dose range. The increase in total exercise duration was larger for the mibefradil 150 mg group than for the placebo group. For the intent-to-treat population, this difference did not reach statistical significance, whereas in the standard population it did (treatment effect 21 s, p = 0.05). The other two ETT variables, time to onset of angina and time to onset of 1 mm ST-segment depression, demonstrated significantly greater effect with mibefradil 150 mg (treatment effects 40 s, p = 0.002, and 55 s, p < 0.001, respectively, for the intent-to-treat population). Mibefradil 150 mg was associated with more adverse events than placebo, specifically, dizziness, leg edema, and postural hypotension. CONCLUSIONS: This study demonstrates that mibefradil 50 mg once daily in the setting of the background long-acting nitrate therapy produces additive antianginal and anti-ischemic effects and is extremely well tolerated. FAU - Frishman, W H AU - Frishman WH AD - Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, New York 10595, USA. FAU - Bittar, N AU - Bittar N FAU - Glasser, S AU - Glasser S FAU - Habib, G AU - Habib G FAU - Smith, W AU - Smith W FAU - Pordy, R AU - Pordy R LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - United States TA - Clin Cardiol JT - Clinical cardiology JID - 7903272 RN - 0 (Benzimidazoles) RN - 0 (Calcium Channel Blockers) RN - 0 (Delayed-Action Preparations) RN - 0 (Tetrahydronaphthalenes) RN - 0 (Vasodilator Agents) RN - 27B90X776A (Mibefradil) RN - G59M7S0WS3 (Nitroglycerin) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Angina Pectoris/*drug therapy/physiopathology MH - Benzimidazoles/administration & dosage/*therapeutic use MH - Calcium Channel Blockers/administration & dosage/*therapeutic use MH - Chronic Disease MH - Delayed-Action Preparations MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Drug Therapy, Combination MH - Electrocardiography MH - Exercise Tolerance MH - Female MH - Follow-Up Studies MH - Hemodynamics/drug effects MH - Humans MH - Male MH - Mibefradil MH - Middle Aged MH - Nitroglycerin/*therapeutic use MH - Prospective Studies MH - Safety MH - Tetrahydronaphthalenes/administration & dosage/*therapeutic use MH - Treatment Outcome MH - Vasodilator Agents/*therapeutic use PMC - PMC6656231 EDAT- 1998/07/21 00:00 MHDA- 1998/07/21 00:01 PMCR- 2009/02/03 CRDT- 1998/07/21 00:00 PHST- 1998/07/21 00:00 [pubmed] PHST- 1998/07/21 00:01 [medline] PHST- 1998/07/21 00:00 [entrez] PHST- 2009/02/03 00:00 [pmc-release] AID - CLC4960210707 [pii] AID - 10.1002/clc.4960210707 [doi] PST - ppublish SO - Clin Cardiol. 1998 Jul;21(7):483-90. doi: 10.1002/clc.4960210707. PMID- 23393894 OWN - NLM STAT- MEDLINE DCOM- 20130410 LR - 20130211 IS - 1592-7830 (Print) IS - 1592-7830 (Linking) VI - 33 IP - 3 Suppl DP - 2011 Jul-Sep TI - [Threshold values for chemical agents in the light of the REACH regulation]. PG - 439-42 AB - The European Regulation 1907/2006 (REACH--Registration, Evaluation, Authorization and Restriction of Chemicals) obliges manufacture companies and import chemicals to assess the risks arising from their use and to take the necessary measures to manage the risks identified. The Chemical Safety Report provides an accurate assessment of hazards to human health and the environment necessary to prepare an exposure scenario for the "identified uses" of the substance. An exposure scenario is the set of conditions that describe how the substance is manufactured or used during its life cycle and how the manufacturer or importer controls, or recommends downstream users to control the 'exposure to humans and the environment. Firms therefore need specific skills. The spectrum of toxicological risk is extremely large, the information required in some cases are very complex and undoubtedly require a thorough knowledge in toxicology and environmental industry. The expertise and experience in toxicology of the occupational physician in this case may become useful in the environmental field as well as another familiar figure of relevant importance is the occupational hygienist who develop exposure scenarios for workers and their uses experience for the exposure scenarios for the consumer. It provides an obvious involvement of medical toxicologists and occupational hygienists for public tasks of control and inspection of chemical safety reports and, locally, even the accuracy of risk that arise from this. FAU - Cavallo, Domenico Maria AU - Cavallo DM AD - Dipartimento di Scienze ed Alta Tecnologia, Università degli Studi dell'Insubria e Melete Srl, AIDII. domenico.cavallo@uninsubria.it FAU - Cattaneo, Andrea AU - Cattaneo A FAU - Colosio, Claudio AU - Colosio C FAU - Moretto, Angelo AU - Moretto A FAU - Carrer, Paolo AU - Carrer P FAU - Bartolucci, Giovanni Battista AU - Bartolucci GB LA - ita PT - English Abstract PT - Journal Article TT - I valori limite per agenti chimici alla luce del regolamento REACH. PL - Italy TA - G Ital Med Lav Ergon JT - Giornale italiano di medicina del lavoro ed ergonomia JID - 9712708 RN - 0 (Air Pollutants) SB - IM MH - Air Pollutants/analysis MH - *Chemical Safety MH - Europe MH - Humans MH - *Occupational Exposure/legislation & jurisprudence MH - *Threshold Limit Values EDAT- 2011/07/01 00:00 MHDA- 2013/04/11 06:00 CRDT- 2013/02/12 06:00 PHST- 2013/02/12 06:00 [entrez] PHST- 2011/07/01 00:00 [pubmed] PHST- 2013/04/11 06:00 [medline] PST - ppublish SO - G Ital Med Lav Ergon. 2011 Jul-Sep;33(3 Suppl):439-42. PMID- 23967723 OWN - NLM STAT- MEDLINE DCOM- 20130919 LR - 20220331 IS - 1784-3286 (Print) IS - 1784-3286 (Linking) VI - 68 IP - 2 DP - 2013 Mar-Apr TI - Chronic wounds in a kidney transplant recipient with moderate renal impairment. PG - 128-31 AB - Calcific uremic arteriolopathy (CUA) or calciphylaxis is a condition predominantly observed in patients with end-stage kidney disease characterized by small vessel calcification, intimal proliferation, endovascular fibrosis and intravascular thrombosis causing down-stream infarction predominantly of skin resulting in extremely painful necrotic ulceration. Several interventions have been proposed in an attempt to attenuate the high mortality associated with CUA. One of the most promising therapeutic approaches is the administration of sodium thiosulfate which is able to chelate cations such as calcium and in this way possibly dissolving tissue calcium deposits into more hydrophilic calcium thiosulfate. Due to the scarcity of reports of CUA patients treated with sodium thiosulfate the safety profile of this drug is not (well) established at this moment especially in patients not receiving kidney replacement therapy. Here, we describe a case of a kidney transplant recipient with CUA and moderately declined kidney function who was treated with sodium thiosulfate and developed important hypernatremia and high anion gap acidosis necessitating significant reduction in dosing. FAU - Vanparys, J AU - Vanparys J AD - Department of Nephrology, University Hospitals Leuven, Leuven, Belgium. FAU - Sprangers, B AU - Sprangers B FAU - Sagaert, X AU - Sagaert X FAU - Kuypers, D R AU - Kuypers DR LA - eng PT - Case Reports PT - Journal Article PL - England TA - Acta Clin Belg JT - Acta clinica Belgica JID - 0370306 SB - IM MH - Aged MH - Calciphylaxis/diagnosis/*etiology/therapy MH - Combined Modality Therapy MH - Diagnosis, Differential MH - Fatal Outcome MH - Female MH - Humans MH - *Kidney Transplantation MH - Renal Insufficiency/*complications MH - Skin Ulcer/diagnosis/*etiology/therapy MH - Thigh EDAT- 2013/08/24 06:00 MHDA- 2013/09/21 06:00 CRDT- 2013/08/24 06:00 PHST- 2013/08/24 06:00 [entrez] PHST- 2013/08/24 06:00 [pubmed] PHST- 2013/09/21 06:00 [medline] AID - 10.2143/ACB.3191 [doi] PST - ppublish SO - Acta Clin Belg. 2013 Mar-Apr;68(2):128-31. doi: 10.2143/ACB.3191. PMID- 16547531 OWN - NLM STAT- MEDLINE DCOM- 20060622 LR - 20071115 IS - 1470-8590 (Print) IS - 1470-8590 (Linking) VI - 5 IP - 1 DP - 2006 TI - A continued role for beta-blocker therapy in heart failure. PG - 15-9 AB - The number of patients with newly diagnosed heart failure continues to grow worldwide, to some extent reflecting the increase in survival after acute coronary syndromes and the aging of the population. The search for new and effective therapies for this condition remains a priority in the 21st century. The use of beta-blockers is now well established in the clinical context of mild and moderate systolic heart failure. The effects of beta-blockade on mortality are additive to those with angiotensin-converting enzyme inhibitor therapy. Recently completed, large, randomized trials provided strong evidence for the use of beta-blockers in severe (NYHA functional class IV) heart failure and in asymptomatic patients with left ventricular systolic dysfunction and recent myocardial infarction. Obviously, patient selection still remains the key to the safe use of beta-blockers in patients with heart failure. Further data from clinical trials have emerged to support similar benefits in terms of mortality and morbidity, a good safety record, and tolerability in patients at extremes of age (children and adults >70 years of age) and in specific clinical circumstances (including diabetes, chronic obstructive airways disease, renal failure, and atrial fibrillation). Recent use of beta-blockers with vasodilatory properties in patients with heart failure and preserved systolic function (so-called diastolic heart failure) appears promising but will require large-scale, long-term trials prior to widespread clinical use. FAU - Korczyk, Dariusz P AU - Korczyk DP AD - Cardiovascular Research Laboratory, Department of Medicine, University of Auckland, New Zealand. FAU - Doughty, Robert N AU - Doughty RN LA - eng PT - Journal Article PL - England TA - Heart Fail Monit JT - Heart failure monitor JID - 101140283 RN - 0 (Adrenergic beta-Antagonists) SB - IM MH - Adrenergic beta-Antagonists/pharmacology/*therapeutic use MH - Arrhythmias, Cardiac/drug therapy MH - Blood Pressure/drug effects MH - Diabetes Complications MH - Echocardiography MH - Heart Failure/*drug therapy MH - Humans MH - Pulmonary Disease, Chronic Obstructive/complications MH - Randomized Controlled Trials as Topic MH - Survival Rate MH - Treatment Outcome MH - Ventricular Function, Left/*drug effects EDAT- 2006/03/21 09:00 MHDA- 2006/06/23 09:00 CRDT- 2006/03/21 09:00 PHST- 2006/03/21 09:00 [pubmed] PHST- 2006/06/23 09:00 [medline] PHST- 2006/03/21 09:00 [entrez] PST - ppublish SO - Heart Fail Monit. 2006;5(1):15-9. PMID- 12483127 OWN - NLM STAT- MEDLINE DCOM- 20030303 LR - 20151119 IS - 0399-8320 (Print) IS - 0399-8320 (Linking) VI - 26 IP - 11 DP - 2002 Nov TI - [Treatment of Crohn's disease with anti-TNF alpha antibodies (infliximab): results of a multicentric and retrospective study]. PG - 973-9 AB - OBJECTIVE: To evaluate the results of infliximab therapy, an anti-TNF-alpha antibody, in patients with severe and refractory Crohn's disease or with fistulas, treated outside the setting of a therapeutic trial. METHODS: All Crohn's disease patients treated at the Departments of Gastroenterology of the University Hospitals of Bordeaux, Nantes, Poitiers, Rennes and Tours were retrospectively analyzed. RESULTS: Sixty-nine patients were treated with a total of 170 infusions of infliximab, 32 patients being treated for refractory Crohn's disease and 37 for fistulas. The median follow-up was 8 months (extremes 1-20). An objective response was observed in 79% of refractory Crohn's disease patients and 78% of fistulazing patients. A remission was observed in 72% and 70% of the patients respectively. Forty-five percent of patients had relapsed within 4 months (extremes 2-7). Immunosuppressive therapy was associated with a lower relapse rate (18% with versus 56% without, P=0.004). Infliximab resulted in a steroid-sparing effect in 73% of patients. Forty adverse events, none of severe grade, were observed in 22% of the patients, without any influence of steroids or immunosuppressive therapy. CONCLUSION: This study confirms that infliximab is very effective in steroid-dependent and fistulazing Crohn's disease. Infliximab has a steroid-sparing effect and immunosuppressive therapy is associated with a reduced relapse rate. Although the tolerance is good in the short term, long term safety remains to be established by further studies. FAU - Doubremelle, Marie AU - Doubremelle M AD - Hépato-Gastroentérologie, Hôtel-Dieu, Nantes. FAU - Bourreille, Arnaud AU - Bourreille A FAU - Zerbib, Frank AU - Zerbib F FAU - Heresbach, Denis AU - Heresbach D FAU - Metman, Etienne Henry AU - Metman EH FAU - Beau, Philippe AU - Beau P FAU - Gournay, Jérôme AU - Gournay J FAU - Galmiche, Jean-Paul AU - Galmiche JP LA - fre PT - Clinical Trial PT - Comparative Study PT - English Abstract PT - Journal Article PT - Multicenter Study TT - Traitement de la maladie de Crohn par anticorps anti-TNF alpha (infliximab): résultats d'une étude multicentrique et rétrospective. PL - France TA - Gastroenterol Clin Biol JT - Gastroenterologie clinique et biologique JID - 7704825 RN - 0 (Antibodies, Monoclonal) RN - 0 (Gastrointestinal Agents) RN - B72HH48FLU (Infliximab) SB - IM MH - Adult MH - Antibodies, Monoclonal/administration & dosage/adverse effects/*therapeutic use MH - Crohn Disease/*drug therapy MH - Data Interpretation, Statistical MH - Female MH - Follow-Up Studies MH - Gastrointestinal Agents/administration & dosage/adverse effects/*therapeutic use MH - Humans MH - Infliximab MH - Male MH - Recurrence MH - Retrospective Studies MH - Time Factors EDAT- 2002/12/17 04:00 MHDA- 2003/03/04 04:00 CRDT- 2002/12/17 04:00 PHST- 2002/12/17 04:00 [pubmed] PHST- 2003/03/04 04:00 [medline] PHST- 2002/12/17 04:00 [entrez] AID - MDOI-GCB-11-2002-26-11-0399-8320-101019-ART3 [pii] PST - ppublish SO - Gastroenterol Clin Biol. 2002 Nov;26(11):973-9. PMID- 12938130 OWN - NLM STAT- MEDLINE DCOM- 20040726 LR - 20061115 IS - 1053-1807 (Print) IS - 1053-1807 (Linking) VI - 18 IP - 3 DP - 2003 Sep TI - Randomized comparison of cognitive function in humans at 0 and 8 Tesla. PG - 342-5 AB - PURPOSE: To discover whether there was a measurable alteration in cognitive performance in humans when exposed to a static magnetic field of 8 Tesla (T). MATERIALS AND METHODS: Twenty-five normal human subjects were evaluated at both 0.05 and 8 T in a randomized order. Six standardized neuropsychological tests were administered and auditory reaction times were assessed. The cognitive assessment included measures of learning and retention, verbal fluency (spontaneous word generation), auditory attention, and auditory working memory. Alternate test forms were utilized to reduce practice effects. The sequential order of testing, 0.05 T first vs. 8 T first exposure, was randomized. The data was analyzed using univariate comparisons for correlated means to assess potential differences under the two conditions. RESULTS: There were no clinically significant differences in any of the measures. On a measure of recognition memory the subjects performed significantly better in the 0.05T condition, but the difference was extremely small, not clinically meaningful, and likely due to statistical artifact. CONCLUSION: This study shows that exposure of the brain to high magnetic fields of up to 8 T does not appear to alter human cognitive performance. CI - Copyright 2003 Wiley-Liss, Inc. FAU - Chakeres, Donald W AU - Chakeres DW AD - Department of Radiology, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA. Chakeres-l@medctr.osu.edu FAU - Bornstein, Robert AU - Bornstein R FAU - Kangarlu, Allahyar AU - Kangarlu A LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 SB - IM MH - Adult MH - Brain/physiology MH - Cognition/*physiology MH - Female MH - Humans MH - Magnetic Resonance Imaging MH - *Magnetics MH - Male MH - Middle Aged MH - Safety EDAT- 2003/08/26 05:00 MHDA- 2004/07/28 05:00 CRDT- 2003/08/26 05:00 PHST- 2003/08/26 05:00 [pubmed] PHST- 2004/07/28 05:00 [medline] PHST- 2003/08/26 05:00 [entrez] AID - 10.1002/jmri.10366 [doi] PST - ppublish SO - J Magn Reson Imaging. 2003 Sep;18(3):342-5. doi: 10.1002/jmri.10366. PMID- 29580167 OWN - NLM STAT- MEDLINE DCOM- 20191017 LR - 20191210 IS - 1545-9632 (Electronic) IS - 1545-9624 (Linking) VI - 15 IP - 6 DP - 2018 Jun TI - Evaluation of heat stress and heat strain among employees working outdoors in an extremely hot environment. PG - 474-480 LID - 10.1080/15459624.2018.1456663 [doi] AB - A heat stress evaluation was conducted among employees engaged in strenuous work in an extremely hot outdoor environment. Environmental conditions that contribute to heat stress along with various physiological indicators of heat strain were monitored on a task-basis for nine employees daily across four workdays. Employees performed moderate to heavy tasks in elevated environmental conditions for longer periods of time than recommended by various heat stress exposure limits. Seven of nine employees showed evidence of excessive heat strain according to criteria yet all employees were able to self-regulate task duration and intensity to avoid heat-related illness. FAU - Methner, Mark AU - Methner M AD - a National Institute for Occupational Safety and Health , Cincinnati , Ohio. FAU - Eisenberg, Judith AU - Eisenberg J AD - a National Institute for Occupational Safety and Health , Cincinnati , Ohio. LA - eng PT - Journal Article PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - Adult MH - Body Temperature/physiology MH - Female MH - Heart Rate/physiology MH - Heat Stress Disorders/prevention & control MH - *Heat-Shock Response MH - *Hot Temperature MH - Humans MH - Male MH - Middle Aged MH - National Institute for Occupational Safety and Health, U.S. MH - Occupational Exposure/*analysis/prevention & control MH - Parks, Recreational MH - United States OTO - NOTNLM OT - Heat strain OT - heat stress OT - heat-related illness OT - rhabdomyolysis EDAT- 2018/03/28 06:00 MHDA- 2019/10/18 06:00 CRDT- 2018/03/28 06:00 PHST- 2018/03/28 06:00 [pubmed] PHST- 2019/10/18 06:00 [medline] PHST- 2018/03/28 06:00 [entrez] AID - 10.1080/15459624.2018.1456663 [doi] PST - ppublish SO - J Occup Environ Hyg. 2018 Jun;15(6):474-480. doi: 10.1080/15459624.2018.1456663. PMID- 8270110 OWN - NLM STAT- MEDLINE DCOM- 19940203 LR - 20071115 IS - 0301-5149 (Print) IS - 0301-5149 (Linking) VI - 80 DP - 1993 TI - BSE--a risk for man through pharmaceutical products? Position and politics of the German pharmaceutical industry. PG - 199-205 AB - Since BSE is not a zoonosis and the occurrence is with some exceptions extremely low or absent, the risk to man through pharmaceuticals is remote. However, the agent of BSE is very resistant and the disease in cattle is always lethal, as are analogous diseases of man. Therefore, the German pharmaceutical industry, through a working group, actively contributes to reasonable measurements leading to a further reduction of any theoretical risk. This theoretical risk has to be evaluated by a balanced consideration of various risk and safety factors. Process validation should be reserved for occasional single cases, since it is still time-consuming and contradicts animal protection. Industry prefers further research into the characteristics and behaviour of the BSE agent. The "Note for Guidance..." recently established by the EC commission seems a reasonable approach for a harmonized attitude of both industry and authorities. The German pharmaceutical industry would appreciate a balanced consideration of both pharmaceutical and food industries, which would also re-establish the confidence of the public. FAU - Danner, K AU - Danner K LA - eng PT - Journal Article PL - Switzerland TA - Dev Biol Stand JT - Developments in biological standardization JID - 0427140 RN - 0 (Prions) SB - IM MH - Animals MH - Cattle MH - Drug Contamination/*prevention & control MH - Drug Industry/*standards MH - Encephalopathy, Bovine Spongiform/prevention & control/*transmission MH - European Union MH - Food Contamination/prevention & control MH - Germany MH - Guidelines as Topic MH - Humans MH - Meat MH - Mice MH - Organ Specificity MH - *Prions/pathogenicity MH - Risk MH - Safety MH - Species Specificity MH - Zoonoses EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] PST - ppublish SO - Dev Biol Stand. 1993;80:199-205. PMID- 11542719 OWN - NASA STAT- MEDLINE DCOM- 20000402 LR - 20191027 IS - 0265-9646 (Print) IS - 0265-9646 (Linking) VI - 5 DP - 1989 Aug TI - Crucial factor: human. Safely extending the human presence in space. PG - 201-16 AB - The concept of advanced manned space missions has captured the interest and imagination of spacefaring nations. However, the physiological and psychological effects of space flight increase in magnitude and significance in the 'extended time-in-space' context. The unencumbered weightless condition enjoyed during short flights might compromise crew productivity upon return to a gravity field and extremely effective countermeasures may be essential. Missions remote from Earth require careful consideration of the medical facilities, psychological support and life support needed. The author discusses pressing issues that must be resolved before the visions of bolder human missions can be realistically fulfilled. FAU - Garshnek, V AU - Garshnek V AD - Science Communications Studies, George Washington University, Washington, DC 20052, USA. LA - eng PT - Journal Article PL - England TA - Space Policy JT - Space policy JID - 100971283 MH - *Adaptation, Physiological MH - *Aerospace Medicine MH - Cosmic Radiation MH - Environmental Monitoring MH - Ergonomics MH - Humans MH - Life Support Systems MH - Safety MH - Space Flight/*trends MH - Task Performance and Analysis MH - Weightlessness/*adverse effects MH - *Weightlessness Countermeasures OID - NASA: 00024856 OTO - NASA OT - NASA Center HQS OT - NASA Discipline General Space Life Sciences FIR - Nicogossian, A E IR - Nicogossian AE IRAD- NASA HQS EDAT- 1989/08/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1989/08/01 00:00 PHST- 1989/08/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1989/08/01 00:00 [entrez] AID - 10.1016/0265-9646(89)90087-8 [doi] PST - ppublish SO - Space Policy. 1989 Aug;5:201-16. doi: 10.1016/0265-9646(89)90087-8. PMID- 24821140 OWN - NLM STAT- MEDLINE DCOM- 20150121 LR - 20140528 IS - 1549-960X (Electronic) IS - 1549-9596 (Linking) VI - 54 IP - 5 DP - 2014 May 27 TI - Applicability Domain ANalysis (ADAN): a robust method for assessing the reliability of drug property predictions. PG - 1500-11 LID - 10.1021/ci500172z [doi] AB - We report a novel method called ADAN (Applicability Domain ANalysis) for assessing the reliability of drug property predictions obtained by in silico methods. The assessment provided by ADAN is based on the comparison of the query compound with the training set, using six diverse similarity criteria. For every criterion, the query compound is considered out of range when the similarity value obtained is larger than the 95th percentile of the values obtained for the training set. The final outcome is a number in the range of 0-6 that expresses the number of unmet similarity criteria and allows classifying the query compound within seven reliability categories. Such categories can be further exploited to assign simpler reliability classes using a traffic light schema, to assign approximate confidence intervals or to mark the predictions as unreliable. The entire methodology has been validated simulating realistic conditions, where query compounds are structurally diverse from those in the training set. The validation exercise involved the construction of more than 1000 models. These models were built using a combination of training set, molecular descriptors, and modeling methods representative of the real predictive tasks performed in the eTOX project (a project whose objective is to predict in vivo toxicological end points in drug development). Validation results confirm the robustness of the proposed assessment methodology, which compares favorably with other classical methods based solely on the structural similarity of the compounds. ADAN characteristics make the method well-suited for estimate the quality of drug predictions obtained in extremely unfavorable conditions, like the prediction of drug toxicity end points. FAU - Carrió, Pau AU - Carrió P AD - Research Programme on Biomedical Informatics (GRIB), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, IMIM (Hospital del Mar Medical Research Institute) , Dr. Aiguader, 88, E-08003 Barcelona, Spain. FAU - Pinto, Marta AU - Pinto M FAU - Ecker, Gerhard AU - Ecker G FAU - Sanz, Ferran AU - Sanz F FAU - Pastor, Manuel AU - Pastor M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140513 PL - United States TA - J Chem Inf Model JT - Journal of chemical information and modeling JID - 101230060 SB - IM MH - Artificial Intelligence MH - *Computer Simulation MH - Drug Discovery/*methods MH - *Drug-Related Side Effects and Adverse Reactions MH - Internet MH - Models, Theoretical MH - Reproducibility of Results MH - Safety EDAT- 2014/05/14 06:00 MHDA- 2015/01/22 06:00 CRDT- 2014/05/14 06:00 PHST- 2014/05/14 06:00 [entrez] PHST- 2014/05/14 06:00 [pubmed] PHST- 2015/01/22 06:00 [medline] AID - 10.1021/ci500172z [doi] PST - ppublish SO - J Chem Inf Model. 2014 May 27;54(5):1500-11. doi: 10.1021/ci500172z. Epub 2014 May 13. PMID- 2736093 OWN - NLM STAT- MEDLINE DCOM- 19890803 LR - 20190824 IS - 0886-4470 (Print) IS - 0886-4470 (Linking) VI - 115 IP - 7 DP - 1989 Jul TI - Secure endoscopic sinus surgery as an adjunct to functional nasal surgery. PG - 822-5 AB - The efficacy of functional endoscopic sinus surgery for the treatment of chronic sinusitis is well established. Two contrasting European techniques are currently in use: that espoused by Wigand, which includes endoscopic exenteration of all the sinus cavities with removal of the middle turbinates, and that developed by Messerklinger, who practices minimal opening of the narrow osteomeatal tract at the anterior ethmoidal sinus to achieve physiological reversal of sinus disease. After exposure to both techniques, one of us (P.H.T.) developed a middle-ground approach that lies between the extremes of the two European schools. The benefits of this middle-ground technique include a high success rate, maximal safety, relative ease of learning, and its ability to be performed as an adjunct to any other indicated functional nasal surgery. FAU - Toffel, P H AU - Toffel PH AD - Department of Otolaryngology-Head and Neck Surgery, University of Southern California School of Medicine, Los Angeles. FAU - Aroesty, D J AU - Aroesty DJ FAU - Weinmann, R H 4th AU - Weinmann RH 4th LA - eng PT - Journal Article PL - United States TA - Arch Otolaryngol Head Neck Surg JT - Archives of otolaryngology--head & neck surgery JID - 8603209 SB - IM MH - Chronic Disease MH - Endoscopy MH - Follow-Up Studies MH - Humans MH - Methods MH - Nasal Septum/*surgery MH - Paranasal Sinuses/*surgery MH - Recurrence MH - Sinusitis/*surgery MH - Tomography, X-Ray Computed MH - Turbinates/*surgery EDAT- 1989/07/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1989/07/01 00:00 PHST- 1989/07/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1989/07/01 00:00 [entrez] AID - 10.1001/archotol.1989.01860310060023 [doi] PST - ppublish SO - Arch Otolaryngol Head Neck Surg. 1989 Jul;115(7):822-5. doi: 10.1001/archotol.1989.01860310060023. PMID- 12652952 OWN - NLM STAT- MEDLINE DCOM- 20030528 LR - 20061115 IS - 0040-3660 (Print) IS - 0040-3660 (Linking) VI - 75 IP - 1 DP - 2003 TI - [Current medico-ecological aspects of internal diseases in the urbanized north]. PG - 30-4 AB - AIM: To define a complex action of extreme climatic and harmful environmental factors of present-day northern industrial city on the course of chronic visceral diseases. MATERIAL AND METHODS: Dynamics of exacerbations of basic therapeutic nosologies was studied basing on the data on 10,169 inpatients treated in therapeutic departments of Surgut hospitals (Khanty-Mansi District) in 1994-1998. In parallel, ambient air of the city was controlled for 3 main climatic and 6 technogenic hazards. The analysis was made by means of medicoecological mapping of residential zones. RESULTS: A common feature of chronic visceral diseases course was determined: maximum number of recurrences in February-March and October-November, minimum number--in July-August. There is a relationship between the recurrences and extreme climatic factors. An increase in the number of exacerbations may be related with suppression of nonspecific resistance of the northerners' organism in these seasons. Differential study of the decompensation rate of chronic noninfectious diseases in residential zones in dependence with the degree of technogenic pollution has shown that areas of the town with high hospitalization rates are exposed to high mean annual pollution with sulfur dioxide, vanadium pentoxide and carbon oxide. Areas with low morbidity had the best environment. CONCLUSION: A combined action of extreme climatic and environment factors of the North plays an essential role in decompensation of chronic diseases in the northerners. Dynamics of recurrent chronic noninfectious diseases may serve a sensitive marker of ecological safety of the region. Design and realization of recreation and rehabilitation measures in ecologically polluted areas of the town are effective for prevention of aggravated chronic visceral diseases. FAU - Karpin, V A AU - Karpin VA LA - rus PT - English Abstract PT - Journal Article TT - Sovremennye mediko-ékologicheskie aspekty vnutrennikh bolezneĭ na ubanizirovannom severe. PL - Russia (Federation) TA - Ter Arkh JT - Terapevticheskii arkhiv JID - 2984818R SB - IM MH - Adult MH - Chronic Disease/epidemiology MH - Disease/*classification MH - Female MH - Humans MH - Male MH - Middle Aged MH - Russia/epidemiology MH - Urbanization EDAT- 2003/03/26 05:00 MHDA- 2003/05/29 05:00 CRDT- 2003/03/26 05:00 PHST- 2003/03/26 05:00 [pubmed] PHST- 2003/05/29 05:00 [medline] PHST- 2003/03/26 05:00 [entrez] PST - ppublish SO - Ter Arkh. 2003;75(1):30-4. PMID- 7835741 OWN - NLM STAT- MEDLINE DCOM- 19950224 LR - 20131121 IS - 0300-9041 (Print) IS - 0300-9041 (Linking) VI - 62 DP - 1994 Dec TI - [Induction of labor with misoprostol]. PG - 407-14 AB - The results obtained with the induction of labor with a synthetic analogue of prostaglandin E1: misoprostol, are presented. We reviewed 149 cases of patients admitted to this hospital (The "Policlínico Escuela Eva Perón") for induction of labor throughout a 13-month period of time since 06/01/92 until 06/30/93. All patients had a medical indication for induction of labor, a single pregnancy, cephalic - vertex presentation, no previous surgical scars on uterus, no contraindications for vaginal delivery, Bishop score below 7, gestational age over 37 weeks, and a reactive NST (Non Stress Test). Misoprostol was used intravaginally in the posterior fornix, in one dose of 100 mcg. In those patients where the spontaneous rupture of membranes was not the cause of induction itself, these were artificially ruptured at the moment of admission if possible depending on obstetric conditions, or no longer than 2 hours afterward. All patients underwent continuous fetal hart rate monitoring, during the active phase of labor. There were no failures of induction since all patients reached the active phase of labor without using oxytocin. There was an extremely high percentage of vaginal deliveries being this figure 96.6%. Only 5 patients had to undergo a cesarean section, 2 because of arrest of labor and 3 because acute fetal distress. Four cases of acute intrauterine fetal distress were registered but none of them were caused by tachysystole or hypercontractility. The mean time from the beginning of induction to delivery was 5 hours and 20 minutes (+/- 2 hs, 40') 70.5% of patients giving birth before 6 hours since admittance.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Bugnon, A AU - Bugnon A AD - Servicio de Tocoginecología del Policlínico Escuela Eva Perón, Universidad Nacional de Rosario, Argentina. FAU - Paniagua, A E AU - Paniagua AE FAU - Postiglione, G AU - Postiglione G FAU - Lardizabal, J L AU - Lardizabal JL LA - spa PT - Comparative Study PT - English Abstract PT - Journal Article TT - Inducción del trabajo de parto con misoprostol. PL - Mexico TA - Ginecol Obstet Mex JT - Ginecologia y obstetricia de Mexico JID - 0376552 RN - 0E43V0BB57 (Misoprostol) SB - IM MH - Adolescent MH - Adult MH - Evaluation Studies as Topic MH - Female MH - Fetal Monitoring MH - Humans MH - Labor, Induced/*methods MH - Middle Aged MH - Misoprostol/*administration & dosage MH - Obstetric Labor Complications MH - Parity MH - Pregnancy MH - Safety EDAT- 1994/12/01 00:00 MHDA- 1994/12/01 00:01 CRDT- 1994/12/01 00:00 PHST- 1994/12/01 00:00 [pubmed] PHST- 1994/12/01 00:01 [medline] PHST- 1994/12/01 00:00 [entrez] PST - ppublish SO - Ginecol Obstet Mex. 1994 Dec;62:407-14. PMID- 23792480 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20130715 LR - 20211021 IS - 2210-2612 (Print) IS - 2210-2612 (Electronic) IS - 2210-2612 (Linking) VI - 4 IP - 8 DP - 2013 TI - Gastric outlet obstruction caused by focal nodular hyperplasia of the liver: A case report and literature review. PG - 681-3 LID - S2210-2612(13)00171-5 [pii] LID - 10.1016/j.ijscr.2013.05.004 [doi] AB - INTRODUCTION: Here, we present a case of gastric outlet obstruction due to focal nodular hyperplasia of the liver. PRESENTATION OF CASE: A 23-year-old female presented to our emergency clinic with nausea, vomiting, and abdominal pain. Endoscopy showed that the prepyloric region of the stomach was externally compressed by a lesion. Computed tomography and magnetic resonance imaging revealed a 70mm solid mass originating from the liver, extending caudally in an exophytic manner, and compressing the stomach. Laparotomy revealed an irregular and exophytic mass originating from the liver, which caused gastric outlet obstruction. The mass was resected with a 10mm safety margin. The histopathology report of the mass returned as focal nodular hyperplasia. DISCUSSION: Gastric outlet obstruction is a clinical syndrome characterized by abdominal pain, nausea, and postprandial vomiting. This clinical condition frequently develops as a result of peptic ulcer disease, pyloric stenosis, and obstruction of pylorus by foreign bodies including phytobezoars, congenital duodenal webs, malignant disorders, and various lesions externally compressing the stomach. Gastric outlet obstruction due to hepatic lesions is extremely rare; few cases have been reported. CONCLUSION: This is the first reported case of gastric outlet obstruction that developed due to focal nodular hyperplasia of the liver. CI - Copyright © 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved. FAU - Eris, Cengiz AU - Eris C AD - Department of Surgery, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. FAU - Yildiz, Mehmet Kamil AU - Yildiz MK FAU - Odabasi, Mehmet AU - Odabasi M FAU - Akbulut, Sami AU - Akbulut S FAU - Abuoglu, Hasan AU - Abuoglu H FAU - Ozkan, Erkan AU - Ozkan E LA - eng PT - Journal Article DEP - 20130517 PL - Netherlands TA - Int J Surg Case Rep JT - International journal of surgery case reports JID - 101529872 PMC - PMC3710892 OTO - NOTNLM OT - Focal nodular hyperplasia OT - Gastric outlet obstruction OT - Liver EDAT- 2013/06/25 06:00 MHDA- 2013/06/25 06:01 PMCR- 2013/05/17 CRDT- 2013/06/25 06:00 PHST- 2013/03/07 00:00 [received] PHST- 2013/04/20 00:00 [revised] PHST- 2013/05/12 00:00 [accepted] PHST- 2013/06/25 06:00 [entrez] PHST- 2013/06/25 06:00 [pubmed] PHST- 2013/06/25 06:01 [medline] PHST- 2013/05/17 00:00 [pmc-release] AID - S2210-2612(13)00171-5 [pii] AID - IJSCR512 [pii] AID - 10.1016/j.ijscr.2013.05.004 [doi] PST - ppublish SO - Int J Surg Case Rep. 2013;4(8):681-3. doi: 10.1016/j.ijscr.2013.05.004. Epub 2013 May 17. PMID- 9247440 OWN - NLM STAT- MEDLINE DCOM- 19970903 LR - 20161124 IS - 0003-1348 (Print) IS - 0003-1348 (Linking) VI - 63 IP - 8 DP - 1997 Aug TI - Office-based breast ultrasonography in a small community surgical practice. PG - 716-9 AB - Ultrasonography is now a universally accepted ancillary modality in the diagnosis and management of breast diseases. The debate is whether general surgeons can become adept in the use of this technology in their daily practice. This is a report of 100 breast ultrasound procedures performed by the author in the confines of the surgical office. This report confirms the already known observation that ultrasonography complements good breast examination and mammography. This experience also proves that ultrasound-guided breast biopsy is safe, highly accurate, and cost-effective. Furthermore, this experience shows that ultrasound-guided interventional breast procedures can be performed safely by any well-trained general surgeon. This is extremely helpful in the smaller communities, where the general surgeon is still rightfully regarded as the expert in the management of breast diseases. FAU - Cabasares, H V AU - Cabasares HV AD - Department of Surgery, Perry Hospital, Georgia, USA. LA - eng PT - Journal Article PL - United States TA - Am Surg JT - The American surgeon JID - 0370522 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Ambulatory Care MH - Biopsy MH - Biopsy, Needle MH - Breast Diseases/*diagnostic imaging/pathology/surgery MH - Breast Neoplasms/diagnostic imaging/pathology MH - Carcinoma/diagnostic imaging/pathology MH - Female MH - Fibrocystic Breast Disease/diagnostic imaging/pathology MH - Follow-Up Studies MH - *General Surgery/education MH - Humans MH - Mammography MH - Middle Aged MH - Papilloma, Intraductal/diagnostic imaging/pathology MH - Paracentesis MH - Physical Examination MH - *Physicians' Offices MH - Safety MH - Ultrasonography, Interventional MH - *Ultrasonography, Mammary EDAT- 1997/08/01 00:00 MHDA- 1997/08/01 00:01 CRDT- 1997/08/01 00:00 PHST- 1997/08/01 00:00 [pubmed] PHST- 1997/08/01 00:01 [medline] PHST- 1997/08/01 00:00 [entrez] PST - ppublish SO - Am Surg. 1997 Aug;63(8):716-9. PMID- 9248499 OWN - NLM STAT- MEDLINE DCOM- 19971009 LR - 20190920 IS - 0001-4575 (Print) IS - 0001-4575 (Linking) VI - 29 IP - 4 DP - 1997 Jul TI - Fatigue, mindset and ecology in the hazard dominant environment. PG - 409-15 AB - Ratings made by 47 experienced drivers to 18 items of a Fatigue Advisory are highly consistent. Every item is rated 'very' or 'extremely important' to the safety of inexperienced drivers. In contrast, 'adequacy of knowledge' about fatigue is rated consistently lower. This inconsistency may reflect a culturally based confusion about fatigue. Education and public awareness campaigns need to emphasize that 'immoderate indulgence of driving' is as dangerous to safety as 'immoderate indulgence of alcohol'. A basic challenge is to improve understanding of the manner in which the experience of fatigue emerges during driving. Study of perceptual/cognitive manifestations aided by operational definition of fatigue as a 'declarative state' renders driving fatigue a definite observable subjective condition arising from continuous operation of a vehicle. Specific cognitive symptoms of fatigue such as boredom, tiredness, inattention, etc. emerging with driving fatigue, are circumscribed within the activity of driving itself and also reflect the particular conditions in which driving fatigue occurs. This approach reveals ecological dimensions to the problem. The specific experiences of driving fatigue are seen to emerge as a function of the driver environment relationship in a particular driving environment. It is suggested that the concept of the 'hazard dominant environment' and the compensating landscape perceptions of 'prospect' and 'refuge' proposed by Appleton [(1995) The Experience of Landscape. Wiley, London] in concert with the concept of environmental 'affordances' provided by Gibson [(1979) An Ecological Approach to Visual Perception. Houghton Mifflin, Boston] open promising possibilities for improving environmental education about driving fatigue. FAU - Nelson, T M AU - Nelson TM AD - Department of Psychology, University of Alberta, Edmonton, Canada. LA - eng PT - Journal Article PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Occupational/prevention & control/psychology MH - *Arousal MH - *Attention MH - Fatigue/prevention & control/*psychology MH - Humans MH - Occupational Diseases/prevention & control/*psychology MH - Proportional Hazards Models MH - Safety Management MH - *Social Environment MH - *Transportation EDAT- 1997/07/01 00:00 MHDA- 1997/07/01 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/07/01 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] AID - S0001457597000201 [pii] AID - 10.1016/s0001-4575(97)00020-1 [doi] PST - ppublish SO - Accid Anal Prev. 1997 Jul;29(4):409-15. doi: 10.1016/s0001-4575(97)00020-1. PMID- 30623466 OWN - NLM STAT- MEDLINE DCOM- 20200727 LR - 20200727 IS - 1751-1097 (Electronic) IS - 0031-8655 (Linking) VI - 95 IP - 4 DP - 2019 Jul TI - Seasonal Minimum and Maximum Solar Ultraviolet Exposure Measurements of Classroom Teachers Residing in Tropical North Queensland, Australia. PG - 1083-1093 LID - 10.1111/php.13081 [doi] AB - The risk of keratinocyte skin cancer, malignant melanoma and ultraviolet radiation (UVR)-induced eye disease is disproportionately higher in Australia and New Zealand compared to equivalent northern hemisphere latitudes. While many teachers are aware of the importance of reinforcing sun safety messages to students, many may not be aware of the considerable personal exposure risk while performing outdoor duties in locations experiencing high to extreme ambient UVR year-round. Personal erythemally effective exposure of classroom teachers in tropical Townsville (19.3°S) was measured to establish seasonal extremes in exposure behavior. Mean daily personal exposure was higher in winter (91.2 J m(-2) , 0.91 Standard Erythema Dose [SED]) than summer (63.3 J m(-2) , 0.63 SED). The range of exposures represents personal exposures that approximate current national guidelines for Australian workers at the study latitude of approximately 1.2 SED (30 J m(-2) effective to the International Commission on Non-Ionizing Radiation Protection). Similar proportions of teachers spent more than 1 h outdoors per day in winter (28.6%) and summer (23.6%) as part of their teaching duties with seasonal differences having little effect on the time of exposure. Personal exposures for teachers peaked during both seasons near school meal break times at 11:00 am and 1:00 pm, respectively. CI - © 2019 American Society for Photobiology. FAU - Downs, Nathan J AU - Downs NJ AUID- ORCID: 0000-0002-3191-6404 AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Igoe, Damien P AU - Igoe DP AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. FAU - Parisi, Alfio V AU - Parisi AV AUID- ORCID: 0000-0001-8430-8907 AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. FAU - Taylor, Olivia AU - Taylor O AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Lazzaroni, Shari L AU - Lazzaroni SL AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Rawlings, Alex AU - Rawlings A AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Garzón-Chavez, Daniel R AU - Garzón-Chavez DR AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. AD - School of Human Medicine, College of Health Sciences, Universidad San Francisco de Quito, Quito, Ecuador. FAU - Harrison, Simone L AU - Harrison SL AD - Faculty of Health, Engineering and Sciences, University of Southern Queensland, Toowoomba, Qld, Australia. AD - Skin Cancer Research Unit, School of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Qld, Australia. AD - College of Medicine and Dentistry, James Cook University, Townsville, Qld, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190227 PL - United States TA - Photochem Photobiol JT - Photochemistry and photobiology JID - 0376425 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Queensland MH - *School Teachers MH - *Seasons MH - *Sunlight MH - *Ultraviolet Rays EDAT- 2019/01/10 06:00 MHDA- 2020/07/28 06:00 CRDT- 2019/01/10 06:00 PHST- 2018/11/12 00:00 [received] PHST- 2018/12/30 00:00 [accepted] PHST- 2019/01/10 06:00 [pubmed] PHST- 2020/07/28 06:00 [medline] PHST- 2019/01/10 06:00 [entrez] AID - 10.1111/php.13081 [doi] PST - ppublish SO - Photochem Photobiol. 2019 Jul;95(4):1083-1093. doi: 10.1111/php.13081. Epub 2019 Feb 27. PMID- 15771039 OWN - NLM STAT- MEDLINE DCOM- 20050415 LR - 20161124 IS - 0009-4773 (Print) IS - 0009-4773 (Linking) VI - 56 IP - 6 DP - 2004 Nov-Dec TI - Intestinal resection and multiple abdominal hernia mesh repair: is the combination safe and feasible? PG - 839-42 AB - In a highly advanced era from the point of view of instrumental diagnostic resolution it is, however, not always possible to obtain a precise preoperative diagnosis. Surgery is sometimes the only decisive solution. In April 2003, a 62-year-old male patient was referred to us for umbilical hernia, diastasis recti abdominis and left-sided inguinal hernia; he also complained of pain in the mesogastric-hypogastric region. This site presented with a hard, non-mobile, painful tumefaction at both superficial and deep palpation. The patient was submitted to various diagnostic examinations (pancolonoscopy, CT, X-ray of the digestive tract and angiography), but only surgery allowed us to establish the specific nature of the tumefaction. The operation consisted in the en-bloc removal of an abscess mass affecting intestinal loops, caecum and appendix and at the same time in the repair of the hernia components with the use of prosthesis in a potentially contaminated area. The tumefaction had originated following acute appendicitis episodes that had determined adherences between the appendix, caecum and ileal loops (histologically confirmed). There are situations that require surgery in order to be explicitly diagnosed and solved. Furthermore, although the use of prosthetic materials in the treatment of hernias in association with intestinal resection is an extreme case, it has also been reported in the international literature that nowadays there are no real contraindications to the implantation of a prosthesis in a potentially infected area. FAU - Campanelli, Giampiero AU - Campanelli G AD - Department of Surgical Sciences, University of Milan, Policlinico Hospital IRCCS, Pad. Beretta Est. FAU - Nicolosi, Filadelfio Massimiliano AU - Nicolosi FM FAU - Pettinari, Diego AU - Pettinari D FAU - Avesani, Ettore Contessini AU - Avesani EC LA - eng PT - Case Reports PT - Journal Article PL - Italy TA - Chir Ital JT - Chirurgia italiana JID - 0151753 SB - IM MH - Abdominal Abscess/diagnosis/radiotherapy/*surgery MH - Abdominal Pain/etiology MH - Acute Disease MH - Angiography MH - Appendicitis/complications MH - Colonoscopy MH - Feasibility Studies MH - Follow-Up Studies MH - Hernia, Abdominal/diagnosis/diagnostic imaging/*surgery MH - Humans MH - Imaging, Three-Dimensional MH - Intestines/*surgery MH - Male MH - Middle Aged MH - Safety MH - *Surgical Mesh MH - Tomography, X-Ray Computed MH - Treatment Outcome EDAT- 2005/03/18 09:00 MHDA- 2005/04/16 09:00 CRDT- 2005/03/18 09:00 PHST- 2005/03/18 09:00 [pubmed] PHST- 2005/04/16 09:00 [medline] PHST- 2005/03/18 09:00 [entrez] PST - ppublish SO - Chir Ital. 2004 Nov-Dec;56(6):839-42. PMID- 29448195 OWN - NLM STAT- MEDLINE DCOM- 20180608 LR - 20180608 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 199 DP - 2018 May TI - Factors affecting the (7)Be surface concentration and its extremely high occurrences over the Scandinavian Peninsula during autumn and winter. PG - 278-285 LID - S0045-6535(18)30254-6 [pii] LID - 10.1016/j.chemosphere.2018.02.052 [doi] AB - Relationships between the beryllium-7 activity concentrations in surface air and meteorological parameters (temperature, atmospheric pressure, and precipitation), teleconnection indices (Arctic Oscillation, North Atlantic Oscillation, and Scandinavian pattern) and number of sunspots are investigated using two multivariate statistical techniques: hierarchical cluster and factor analysis. The beryllium-7 surface measurements over 1995-2011, at four sampling sites located in the Scandinavian Peninsula, are obtained from the Radioactivity Environmental Monitoring Database. In all sites, the statistical analyses show that the beryllium-7 concentrations are strongly linked to temperature. Although the beryllium-7 surface concentration exhibits the well-characterised spring/summer maximum, our study shows that extremely high beryllium-7 concentrations, defined as the values exceeding the 90(th) percentile in the data records for each site, also occur over the October-March period. Two types of autumn/winter extremes are distinguished: type-1 when the number of extremes in a given month is less than three, and type-2 when at least three extremes occur in a month. Factor analysis performed for these autumn/winter events shows a weaker effect of temperature and a stronger impact of the transport and production signal on the beryllium-7 concentrations. Further, the majority of the type-2 extremes are associated with a very high monthly Scandinavian teleconnection index. The type-2 extremes that occurred in January, February and March are also linked to sudden stratospheric warmings of the Arctic vortex. Our results indicate that the Scandinavian teleconnection index might be a good indicator of the meteorological conditions facilitating extremely high beryllium-7 surface concentrations over Scandinavia during autumn and winter. CI - Copyright © 2018 Elsevier Ltd. All rights reserved. FAU - Ajtić, J AU - Ajtić J AD - Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobođenja 18, 11000, Belgrade, Serbia. Electronic address: jelena.ajtic@vet.bg.ac.rs. FAU - Brattich, E AU - Brattich E AD - Department of Physics and Astronomy, Alma Mater Studiorum University of Bologna, Via Irnerio 46, 40126, Bologna, BO, Italy. Electronic address: erika.brattich@unibo.it. FAU - Sarvan, D AU - Sarvan D AD - Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobođenja 18, 11000, Belgrade, Serbia. Electronic address: darko.sarvan@vet.bg.ac.rs. FAU - Djurdjevic, V AU - Djurdjevic V AD - Institute of Meteorology, Faculty of Physics, University of Belgrade, Studentski trg 18, 11000, Belgrade, Serbia. Electronic address: vdj@ff.bg.ac.rs. FAU - Hernández-Ceballos, M A AU - Hernández-Ceballos MA AD - European Commission, Joint Research Centre, Knowledge for Nuclear Security and Safety Unit Radioactivity Environmental Monitoring Group, Via Enrico Fermi 2749, I-21027, Ispra, VA, Italy. Electronic address: miguel-angel.hernandez-ceballos@ec.europa.eu. LA - eng PT - Journal Article DEP - 20180209 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Air Pollutants, Radioactive) RN - 0 (Beryllium-7) RN - 0 (Radioisotopes) RN - OW5102UV6N (Beryllium) SB - IM MH - Air Pollutants, Radioactive/*analysis MH - Atmosphere/chemistry MH - Atmospheric Pressure MH - Beryllium/*analysis MH - Climate Change MH - Factor Analysis, Statistical MH - Radiation Monitoring/*methods MH - Radioisotopes/*analysis MH - Scandinavian and Nordic Countries MH - Seasons MH - Temperature OTO - NOTNLM OT - Beryllium-7 OT - Meteorological parameters OT - Multivariate analysis OT - Sudden stratospheric warming OT - Surface air OT - Teleconnection indices EDAT- 2018/02/16 06:00 MHDA- 2018/06/09 06:00 CRDT- 2018/02/16 06:00 PHST- 2017/11/10 00:00 [received] PHST- 2018/02/04 00:00 [revised] PHST- 2018/02/08 00:00 [accepted] PHST- 2018/02/16 06:00 [pubmed] PHST- 2018/06/09 06:00 [medline] PHST- 2018/02/16 06:00 [entrez] AID - S0045-6535(18)30254-6 [pii] AID - 10.1016/j.chemosphere.2018.02.052 [doi] PST - ppublish SO - Chemosphere. 2018 May;199:278-285. doi: 10.1016/j.chemosphere.2018.02.052. Epub 2018 Feb 9. PMID- 9876647 OWN - NLM STAT- MEDLINE DCOM- 19990128 LR - 20200604 IS - 1086-8089 (Print) IS - 1938-3797 (Electronic) IS - 1086-8089 (Linking) VI - 1 IP - 1 DP - 1997 Jan-Mar TI - Comparison of outpatient laparoscopic cholecystectomy in a private nonteaching hospital versus a private teaching community hospital. PG - 51-3 AB - The development of laparoscopic cholecystectomy has allowed the introduction of outpatient surgery for biliary tract disease. However, there appears to be a wide variation of the interpretation of "outpatient surgery," ranging from discharge the same day to keeping patients for overnight observation. We prospectively reviewed the last 50 chole-cystectomies performed at Spartanburg Regional Medical Center, a private teaching institution, and Upstate Carolina Medical Center, a private nonteaching hospital. All cholecystectomies were performed by board certified surgeons or surgical residents under the supervision of board certified surgeons. Spartanburg Regional Medical Center's standard was 23-hour observation with 9 patients (18%) being discharged home the day of surgery. Upstate Carolina Medical Center's standard was discharge home (usually 4-8 hours after completion of the procedure) with 39 patients (78%) discharged the same day. No patient discharged the same day presented back with any significant complication. Comorbid disease, biliary pancreatitis, ascending cholangitis, gangrenous gallbladder, extreme age and living conditions and conversion to open were factors considered for admission. Intra-operative difficulty such as oozing, excessive adhesiolysis, postoperative nausea, vomiting or pain control were also indications for overnight admissions. The extra 15 to 19 hours for routine observation did not change any treatment for any of the 41 patients and resulted in additional cost to the hospital of approximately $15,000. We conclude that same day, outpatient laparoscopic cholecystectomy can be done safely with discharge home 4 to 8 hours postoperative without significant morbidity in selective patients. FAU - Smith, M 2nd AU - Smith M 2nd AD - Spartanburg Regional Medical Center, SC, USA. FAU - Wheeler, W AU - Wheeler W FAU - Ulmer, M B AU - Ulmer MB LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PL - United States TA - JSLS JT - JSLS : Journal of the Society of Laparoendoscopic Surgeons JID - 100884618 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Ambulatory Surgical Procedures/*standards MH - Child MH - Cholecystectomy, Laparoscopic/mortality/*statistics & numerical data MH - Hospitals, Community/*standards/statistics & numerical data MH - Hospitals, Private/statistics & numerical data MH - Hospitals, Teaching/*standards/statistics & numerical data MH - Humans MH - Length of Stay/statistics & numerical data MH - Middle Aged MH - Prognosis MH - Safety MH - Survival Rate MH - Treatment Outcome PMC - PMC3015227 EDAT- 1997/01/01 00:00 MHDA- 1999/01/07 03:04 PMCR- 1997/01/01 CRDT- 1997/01/01 00:00 PHST- 1997/01/01 00:00 [pubmed] PHST- 1999/01/07 03:04 [medline] PHST- 1997/01/01 00:00 [entrez] PHST- 1997/01/01 00:00 [pmc-release] PST - ppublish SO - JSLS. 1997 Jan-Mar;1(1):51-3. PMID- 22830116 OWN - NLM STAT- MEDLINE DCOM- 20120820 LR - 20120726 IS - 0026-9050 (Print) IS - 0026-9050 (Linking) VI - 333 IP - 5 DP - 2012 May TI - [About the complex system of requirements on the everyday safety of servicemen]. PG - 39-43 AB - The article is based on studies of medical and technical problems of habitability, livelihoods, military; environment and service troops justified the structure and content of the complex system requirements on the everyday safety of servicemen. It summarizes the scientific and educational methods to the accounting of the human factor in military facilities. Allowable limits and hygienic standards are the foundation of life safety of personnel. Extreme conditions are characterized by emergencies and injury. FAU - Kudrin, I D AU - Kudrin ID FAU - Aleksandrov, V N AU - Aleksandrov VN LA - rus PT - English Abstract PT - Journal Article PL - Russia (Federation) TA - Voen Med Zh JT - Voenno-meditsinskii zhurnal JID - 2984871R SB - IM MH - Female MH - Humans MH - Male MH - *Military Personnel MH - *Safety Management/legislation & jurisprudence/methods/organization & administration/standards EDAT- 2012/07/27 06:00 MHDA- 2012/08/21 06:00 CRDT- 2012/07/27 06:00 PHST- 2012/07/27 06:00 [entrez] PHST- 2012/07/27 06:00 [pubmed] PHST- 2012/08/21 06:00 [medline] PST - ppublish SO - Voen Med Zh. 2012 May;333(5):39-43. PMID- 11982029 OWN - NASA STAT- MEDLINE DCOM- 20020524 LR - 20081121 IS - 0075-9422 (Print) IS - 0075-9422 (Linking) VI - 6 DP - 1968 TI - Resistance of organisms to extreme influences in relation to some exobiological problems. PG - 79-86 AB - The conditions to which organisms have not been able to adapt in the process of evolution are called extreme influences or extreme conditions. The experiments show that organisms and cells have a potential for resistance; among animals, there are forms that are able to stand extremely low temperatures (from -80 to -269 degrees) when the water content of their tissues is large enough. Some species of protozoa can tolerate ionizing radiation in doses (500-1800 kr) of many orders exceeding those existing on the Earth and out in space. There are different ways of obtaining "protection" against ultraviolet (UV) shortwave sun radiation detained by the ozone layers of the Earth's atmosphere (photoreactivation, biological screens non-permeable for UV light, etc.). Many insects, especially alpine species, do not require as much oxygen as is contained in lower layers of the Earth's atmosphere. Hence, earth organisms possess some "margins of safety", enabling us to suggest the existence of similar biological systems in conditions different from the Earth's. The resistance to the action of extreme factors is probably connected with the resistance of biopolymers, protein complexes of cells and also with the capability of the organism to recover from damage. FAU - Lozina-Lozinsky, L K AU - Lozina-Lozinsky LK AD - Academy of Sciences of the USSR, Moscow, USSR. LA - eng PT - Journal Article PL - Netherlands TA - Life Sci Space Res JT - Life sciences and space research JID - 1250331 MH - Animals MH - Ciliophora/*growth & development MH - *Cold Temperature MH - Exobiology MH - Lepidoptera/*growth & development MH - Metamorphosis, Biological MH - Paramecium/*radiation effects MH - Radiation Tolerance MH - Temperature MH - *Ultraviolet Rays OID - NASA: 00027666 EDAT- 1968/01/01 00:00 MHDA- 2002/05/25 10:01 CRDT- 1968/01/01 00:00 PHST- 1968/01/01 00:00 [pubmed] PHST- 2002/05/25 10:01 [medline] PHST- 1968/01/01 00:00 [entrez] PST - ppublish SO - Life Sci Space Res. 1968;6:79-86. PMID- 29558070 OWN - NLM STAT- MEDLINE DCOM- 20180405 LR - 20180405 IS - 0869-866X (Print) IS - 0869-866X (Linking) VI - 24 IP - 4 DP - 2016 Jul-Aug TI - [The comparative evaluation of level of security culture in medical organizations]. PG - 204-8 AB - The study was carried out on the basis of clinic “Medicine” in 2014-2015 concerning security culture. The sampling included 465 filled HSPSC questionnaires. The comparative analysis of received was implemented. The “Zubovskaia district hospital” Having no accreditation according security standards and group of clinics from USA functioning for many years in the system of patient security support were selected as objects for comparison. The evaluation was implemented concerning dynamics of security culture in organization at implementation of strategies of security of patients during 5 years and comparison of obtained results with USA clinics was made. The study results demonstrated that in conditions of absence of implemented standards of security in medical organization total evaluation of security remains extremely low. The study of security culture using HSPSC questionnaire is an effective tool for evaluating implementation of various strategies of security ofpatient. The functioning in the system of international standards of quality, primarily JCI standards, permits during several years to achieve high indices of security culture. FAU - Roitberg, G E AU - Roitberg GE FAU - Kondratova, N V AU - Kondratova NV FAU - Galanina, E V AU - Galanina EV LA - rus PT - Comparative Study PT - Journal Article PL - Russia (Federation) TA - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med JT - Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny JID - 101270373 SB - IM MH - Hospitals/*standards MH - Humans MH - Patient Safety/*standards MH - Russia MH - United States EDAT- 2016/07/01 00:00 MHDA- 2018/04/06 06:00 CRDT- 2018/03/21 06:00 PHST- 2018/03/21 06:00 [entrez] PHST- 2016/07/01 00:00 [pubmed] PHST- 2018/04/06 06:00 [medline] PST - ppublish SO - Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med. 2016 Jul-Aug;24(4):204-8. PMID- 11539238 OWN - NASA STAT- MEDLINE DCOM- 19970327 LR - 20190915 IS - 0273-1177 (Print) IS - 0273-1177 (Linking) VI - 15 IP - 3 DP - 1995 Mar TI - Planetary protection considerations for MarsNet and Mars sample return missions. PG - 277-80 AB - The ESA MarsNet mission proposal consists most probably of a trio of Mars landers. These landers each contain a variety of scientific equipment. The network of stations demands for a definition of its planetary protection requirements. With respect to the MarsNet mission only forward contamination problems will be considered. Future involvement of European efforts in planetary exploration including sample returns will also raise the problem of back contamination. A tradeoff study for the overall scientific benefit with respect to the approximative cost is necessary. Planetary protection guide-lines will be proposed by an interdisciplinary and international board of experts working in the fields of both biology and planetary science. These guide-lines will have to be flexible in order to be modified with respect to new research results, e.g. on adaptation of microorganisms to extreme (space) conditions. Experiments on the survival of microorganisms at conditions of simulated Mars surface and subsurface will have to be conducted in order to obtain a baseline data collection as a reference standard for future guide-lines. FAU - Lindberg, C AU - Lindberg C AD - DLR, Institute of Aerospace Medicine, Biophysics Division, Köln, Germany. FAU - Horneck, G AU - Horneck G LA - eng PT - Journal Article PL - England TA - Adv Space Res JT - Advances in space research : the official journal of the Committee on Space Research (COSPAR) JID - 9878935 MH - *Containment of Biohazards MH - Environmental Microbiology MH - Environmental Pollution/*prevention & control MH - Equipment Contamination/prevention & control MH - *Exobiology MH - Extraterrestrial Environment MH - *Mars MH - Space Flight/instrumentation/*standards MH - *Space Simulation MH - Spacecraft/instrumentation/standards MH - Sterilization/methods OID - NASA: 00019760 EDAT- 1995/03/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1995/03/01 00:00 PHST- 1995/03/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1995/03/01 00:00 [entrez] AID - 10.1016/s0273-1177(99)80097-0 [doi] PST - ppublish SO - Adv Space Res. 1995 Mar;15(3):277-80. doi: 10.1016/s0273-1177(99)80097-0. PMID- 12178835 OWN - PIP STAT- MEDLINE DCOM- 19900707 LR - 20031114 IS - 0740-6835 (Print) IS - 0740-6835 (Linking) VI - 10 IP - 5 DP - 1989 Sep-Oct TI - Woman and the fetus: the social construction of conflict. PG - 14-5 FAU - Chavkin, W AU - Chavkin W LA - eng PT - Journal Article PL - United States TA - Conscience JT - Conscience (Washington, D.C.) JID - 101096078 MH - *Abortion, Induced MH - *Acquired Immunodeficiency Syndrome MH - Americas MH - Developed Countries MH - Disease MH - Economics MH - Family Planning Services MH - *Fetus MH - HIV Infections MH - Health MH - *Human Rights MH - *Maternal Welfare MH - North America MH - Pregnancy MH - Reproduction MH - Socioeconomic Factors MH - United States MH - Virus Diseases MH - *Women's Rights OID - PIP: 058983 OID - POP: 00192138 OAB - In recent court cases, an emerging theme is the consideration of a pregnant woman's safety only in relation to her role as carrier of the fetus. This situation has implications on medicine and health as well as social and political ones. In extreme cases, this places the women as an opponent of the fetus when she asserts her own interest. This could effect health service delivery and especially to those of lesser means. This brings into conflict the woman as a protector of the fetus vs. the woman as an adult decision maker. The Roe v. Wade case made women and doctors the decision makers and restricted the role of the state. The recent debate over fetal rights conceals the real conflict over the rights, status and existence of women. Actually, the struggle is over the social understanding of women in their roles as society changes. The attention given to the fetus distracts from the real problem-the lack of resources available for maternal and child health. The inability to change these inequities puts women and babies in danger and, with the drug and AIDS epidemics, there is an urgent need for positive responses. OABL- eng OTO - PIP OT - *Abortion, Induced OT - *Acquired Immunodeficiency Syndrome OT - Americas OT - Developed Countries OT - Diseases OT - Economic Factors OT - Family Planning OT - Fertility Control, Postconception OT - *Fetus--legal aspects OT - Health OT - Hiv Infections OT - *Human Rights OT - *Maternal Health OT - North America OT - Northern America OT - Pregnancy OT - Reproduction OT - Socioeconomic Factors OT - United States OT - Viral Diseases OT - *Women's Status GN - PIP: TJ: CONSCIENCE EDAT- 1989/09/01 00:00 MHDA- 2002/10/09 04:00 CRDT- 1989/09/01 00:00 PHST- 1989/09/01 00:00 [pubmed] PHST- 2002/10/09 04:00 [medline] PHST- 1989/09/01 00:00 [entrez] PST - ppublish SO - Conscience. 1989 Sep-Oct;10(5):14-5. PMID- 16125634 OWN - NLM STAT- MEDLINE DCOM- 20051013 LR - 20061115 IS - 1062-0303 (Print) IS - 1062-0303 (Linking) VI - 23 IP - 3 DP - 2005 Sep TI - Upsetting the apple cart: a community anticoagulation clinic survey of life event factors that undermine safe therapy. PG - 105-11 AB - Anticoagulation therapy is a life-enhancing therapy for patients who are at risk for embolic events secondary to atrial fibrillation, valve replacement, and other comorbidities. Clinicians are motivated to decrease the amount of time that patients are either under- or over-anticoagulated, common conditions that decrease patient safety at either extreme. The primary purpose of this descriptive study was to examine the relationship between personal life event factors as measured by Norbeck's Life Events Questionnaire, core demographics such as age and income, and anticoagulation regulation. Although many factors affect anticoagulation therapy, the precise impact of life events, positive or negative, is unknown. The salient findings of this study (n = 202) showed a small, though statistically significant, inverse relationship (r = -0.184, P < .01) between negative life events and decreased time within therapeutic international normalized ratio. Total Life Event scores showed a statistically significant inverse relationship (r = -0.159, P < .05) to international normalized ratio time within therapeutic level. Lower income was inversely associated with higher negative Life Event scores (r = -0.192, P < .01). The findings demonstrate the need for strategies that address the potential impact of life events in conjunction with coexisting screening measures used in anticoagulation clinics. Implications for this study are limited by lack of methodology documenting concurrent social support factors and limitations of the research tool to reflect life event issues specific to outpatient seniors. FAU - Edmundson, Sarah AU - Edmundson S AD - Dominican Hospital, Catholic Healthcare West, Santa Cruz, California, USA. FAU - Stuenkel, Diane L AU - Stuenkel DL FAU - Connolly, Phyllis M AU - Connolly PM LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Vasc Nurs JT - Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing JID - 9014475 RN - 0 (Anticoagulants) MH - Adult MH - Aged MH - Aged, 80 and over MH - Ambulatory Care Facilities MH - Anticoagulants/*administration & dosage MH - California MH - *Drug Monitoring MH - Female MH - Humans MH - *Life Change Events MH - Male MH - Middle Aged MH - *Patient Compliance/psychology MH - Safety Management EDAT- 2005/08/30 09:00 MHDA- 2005/10/14 09:00 CRDT- 2005/08/30 09:00 PHST- 2005/08/30 09:00 [pubmed] PHST- 2005/10/14 09:00 [medline] PHST- 2005/08/30 09:00 [entrez] AID - S1062-0303(05)00100-7 [pii] AID - 10.1016/j.jvn.2005.07.001 [doi] PST - ppublish SO - J Vasc Nurs. 2005 Sep;23(3):105-11. doi: 10.1016/j.jvn.2005.07.001. PMID- 24110752 OWN - NLM STAT- MEDLINE DCOM- 20150730 LR - 20200928 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2013 DP - 2013 TI - Theoretical analysis of body hair movement in ELF electric field exposure in different environmental conditions. PG - 4573-6 LID - 10.1109/EMBC.2013.6610565 [doi] AB - To elucidate the mechanism of the biological effect of ELF (extremely low frequency, 0-300 Hz) electric field and to settle appropriate safety standards, the body hair movement in AC electric field exposure was analyzed. We derived the equation of motion to describe the body hair movement cause by the electric force, and obtained an analytic solution for AC input. We applied this solution to practical conditions and clarified the body hair movement in AC electric field exposure. Using this solution, we analyzed the body hair movement in different humidity and verified the validity of the analysis in experiments. FAU - Iida, Ken AU - Iida K FAU - Shimizu, Hisae O AU - Shimizu HO FAU - Shimizu, Koichi AU - Shimizu K LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - *Electricity MH - Hair/*physiology MH - Humans MH - Humidity MH - *Models, Theoretical MH - Movement MH - Reproducibility of Results EDAT- 2013/10/11 06:00 MHDA- 2015/08/01 06:00 CRDT- 2013/10/11 06:00 PHST- 2013/10/11 06:00 [entrez] PHST- 2013/10/11 06:00 [pubmed] PHST- 2015/08/01 06:00 [medline] AID - 10.1109/EMBC.2013.6610565 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:4573-6. doi: 10.1109/EMBC.2013.6610565. PMID- 10834242 OWN - NLM STAT- MEDLINE DCOM- 20000628 LR - 20100313 IS - 0067-8856 (Print) IS - 0067-8856 (Linking) VI - 36 DP - 2000 TI - Numerical simulation of a child restraint system in an aircraft crash-test. PG - 257-62 AB - Studies conducted at the FAA Civil Aeromedical Institute have shown that when used in aircraft, automotive child restraint devices do not always provide the level of safety desired. Various factors that contribute to poor performance, such as seat belt anchor location, cushion stiffness, and child restraint device design features, were evaluated by a dynamic impact test program. To efficiently continue the research, a computer model was developed using MADYMO. Results of two of the impact tests were used to validate the model. Both test configurations utilized a typical commercial transport airplane passenger seat and a popular automotive child restraint device. These tests were considered representative of the extremes of child restraint device and occupant kinematics due to variance in seat belt anchor location. Details are presented of the test parameters and geometry, as well as cushion and restraint system properties. Test and modelling results for these two impact conditions are summarized and compared. Parametric studies were then conducted that used the model to investigate the effect of cushion stiffness, belt anchor spacing, and initial belt tension. FAU - Oggero, E AU - Oggero E AD - Mechanical Engineering Department, Ohio State University, Columbus 43210, USA. FAU - Pipino, M AU - Pipino M FAU - Deweese, R AU - Deweese R FAU - Mugnai, A AU - Mugnai A FAU - Aljundi, B AU - Aljundi B FAU - Pagnacco, G AU - Pagnacco G LA - eng PT - Journal Article PL - United States TA - Biomed Sci Instrum JT - Biomedical sciences instrumentation JID - 0140524 SB - IM MH - *Accidents, Aviation MH - Child, Preschool MH - Humans MH - Manikins MH - *Models, Theoretical MH - *Protective Devices MH - Safety MH - Seat Belts EDAT- 2000/06/02 09:00 MHDA- 2000/07/06 11:00 CRDT- 2000/06/02 09:00 PHST- 2000/06/02 09:00 [pubmed] PHST- 2000/07/06 11:00 [medline] PHST- 2000/06/02 09:00 [entrez] PST - ppublish SO - Biomed Sci Instrum. 2000;36:257-62. PMID- 11539234 OWN - NASA STAT- MEDLINE DCOM- 19970326 LR - 20190915 IS - 0273-1177 (Print) IS - 0273-1177 (Linking) VI - 15 IP - 3 DP - 1995 Mar TI - Modern aspects of planetary protection and requirements to sterilization of space hardware. PG - 251-5 AB - The viewpoint of working group of Russian experts on the problem of planetary protection for future manned and unmanned Mars mission is presented. Recent data of Martian environment and on survival of terrestrial microorganisms in extreme conditions were used for detailed analysis and overview of planetary protection measures in regard to all possible flight situations including accidental landing. The special emphasis on "Mars-94" mission was done. This analysis resulted in revised formulation of spacecraft sterilization requirements and possible measures for their best implementation. New general combined approach to spacecraft sterilization was proposed. It includes penetrating radiation and heat treatment of spacecraft parts and components which is to be carried out before the final assembly of spacecraft and gaseous radiation sterilization of the whole spacecraft during the flight to Mars (or from Mars for return missions). FAU - Demidov, V V AU - Demidov VV AD - Institute of Molecular Genetics of Russian Academy of Sciences, Moscow. FAU - Goncharov, A A AU - Goncharov AA FAU - Osipov, V B AU - Osipov VB FAU - Trofimov, V I AU - Trofimov VI LA - eng PT - Journal Article PL - England TA - Adv Space Res JT - Advances in space research : the official journal of the Committee on Space Research (COSPAR) JID - 9878935 MH - Containment of Biohazards/standards MH - Environmental Microbiology MH - Environmental Pollution/prevention & control MH - *Exobiology MH - *Extraterrestrial Environment MH - *Mars MH - Planets MH - Russia MH - Space Flight/*standards MH - Spacecraft/instrumentation/*standards MH - Sterilization/*methods OID - NASA: 00019756 EDAT- 1995/03/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1995/03/01 00:00 PHST- 1995/03/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1995/03/01 00:00 [entrez] AID - 10.1016/s0273-1177(99)80093-3 [doi] PST - ppublish SO - Adv Space Res. 1995 Mar;15(3):251-5. doi: 10.1016/s0273-1177(99)80093-3. PMID- 8213241 OWN - NLM STAT- MEDLINE DCOM- 19931115 LR - 20161020 IS - 0893-8652 (Print) IS - 0893-8652 (Linking) VI - 6 IP - 5 DP - 1993 Sep-Oct TI - Prolonged delirium tremens requiring massive doses of medication. PG - 502-4 AB - Delirium tremens might last for weeks and treatment requires massive benzodiazepine doses, yet it is possible to manage patients with this condition successfully. In this case of delirium tremens, standard agents at the usual recommended doses were not sufficient to achieve control of confusion and agitation or to stabilize neurologic and cardiovascular parameters. The patient required extraordinarily high doses of central nervous system depressants for an extended period. Midazolam, a short-acting benzodiazepine, was used but was associated with metabolic acidosis and was extremely expensive. Although high-dose midazolam should probably be avoided, extremely high dose benzodiazepine use for an extended period might be necessary in some cases. In this circumstance we advise diazepam because of its low cost and relative safety. The tendencies to withhold large doses for fear of side effects or to give up in cases requiring prolonged intensive support must be resisted to minimize the mortality from this severe illness. FAU - Wolf, K M AU - Wolf KM AD - Department of Medical Education, St. Margaret Memorial Hospital, Pittsburgh, PA. FAU - Shaughnessy, A F AU - Shaughnessy AF FAU - Middleton, D B AU - Middleton DB LA - eng PT - Case Reports PT - Journal Article PL - United States TA - J Am Board Fam Pract JT - The Journal of the American Board of Family Practice JID - 8807505 RN - 12794-10-4 (Benzodiazepines) SB - IM CIN - J Am Board Fam Pract. 1994 Mar-Apr;7(2):184-5. PMID: 8184713 MH - Aged MH - Alcohol Withdrawal Delirium/*drug therapy/economics MH - Benzodiazepines/*administration & dosage MH - Drug Costs MH - Humans MH - Infusions, Intravenous MH - Length of Stay MH - Male EDAT- 1993/09/01 00:00 MHDA- 1993/09/01 00:01 CRDT- 1993/09/01 00:00 PHST- 1993/09/01 00:00 [pubmed] PHST- 1993/09/01 00:01 [medline] PHST- 1993/09/01 00:00 [entrez] PST - ppublish SO - J Am Board Fam Pract. 1993 Sep-Oct;6(5):502-4. PMID- 2720045 OWN - NLM STAT- MEDLINE DCOM- 19890629 LR - 20061115 IS - 0013-5585 (Print) IS - 0013-5585 (Linking) VI - 34 IP - 3 DP - 1989 Mar TI - [Comparative study of unidirectional transducers for invasive blood pressure monitoring]. PG - 34-41 AB - This paper reports on the results of a study in which the offset drift, sensitivity error and drift, as well as the linearity error of six DPT's were investigated under normal ambient conditions and varying conditions of temperature, light, operating time and variation of supply voltage. In addition, the dynamic response, and the influence of storage at extreme temperatures, and resterilisation, was examined. The electrical and mechanical safety/reliability of DPT's was also investigated. The results obtained are compared. FAU - Matzek, F AU - Matzek F FAU - Boenick, U AU - Boenick U FAU - Frucht, U AU - Frucht U FAU - Schroeder, P M AU - Schroeder PM LA - ger PT - Comparative Study PT - English Abstract PT - Journal Article TT - Vergleichende Untersuchung von Einwegtransducern zur invasiven Blutdruckmessung. PL - Germany TA - Biomed Tech (Berl) JT - Biomedizinische Technik. Biomedical engineering JID - 1262533 SB - IM MH - Blood Pressure Determination/*instrumentation MH - Equipment Design MH - Humans MH - Microcomputers MH - Signal Processing, Computer-Assisted/instrumentation MH - *Transducers MH - *Transducers, Pressure EDAT- 1989/03/01 00:00 MHDA- 1989/03/01 00:01 CRDT- 1989/03/01 00:00 PHST- 1989/03/01 00:00 [pubmed] PHST- 1989/03/01 00:01 [medline] PHST- 1989/03/01 00:00 [entrez] PST - ppublish SO - Biomed Tech (Berl). 1989 Mar;34(3):34-41. PMID- 6269242 OWN - NLM STAT- MEDLINE DCOM- 19811118 LR - 20131121 IS - 0039-6060 (Print) IS - 0039-6060 (Linking) VI - 90 IP - 4 DP - 1981 Oct TI - Operative and chemotherapeutic management of malignant glucagon-producing tumors. PG - 713-9 AB - Glucagon-producing tumors of the pancreas are among the rarest forms of islet cell tumors. Two patients are described in whom the characteristic dermatitis, glucose intolerance, weight loss, and anemia of the glucagonoma syndrome were due to a metastasizing islet cell carcinoma. In both, removal of the primary tumor with a distal pancreatectomy brought marked relief of all clinical symptoms for 1- and 2-year periods. Because streptozocin, the usual chemotherapeutic agent for these tumors, is quite toxic and frequently unsuccessful dimethyltriazenoimidazole carboximide (DTIC) was used for recurrence after operation. The first patient began taking DTIC when his rash reappeared and his immunoreactive glucagon (IRG) level rose to 6,000 pg/ml (normal, less than 200 pg/ml). Within 3 months, his rash was gone, and IRG level was 75 pg/ml. The second patient developed a neoplastic gastrocolic fistula and was extremely emaciated. With DTIC, the fistula healed, and he gained weight and returned to work. His IRG level has decreased from 2,975 to 200 pg/ml. No side-effects were noted during chemotherapy. Temporary palliation of malignant glucagon-producing neoplasms can be achieved by cytoreductive surgery. When the life-threatening symptoms of this syndrome recur, DTIC chemotherapy seems indicated because of its safety and effectiveness. FAU - Prinz, R A AU - Prinz RA FAU - Badrinath, K AU - Badrinath K FAU - Banerji, M AU - Banerji M FAU - Sparagana, M AU - Sparagana M FAU - Dorsch, T R AU - Dorsch TR FAU - Lawrence, A M AU - Lawrence AM LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Surgery JT - Surgery JID - 0417347 RN - 7GR28W0FJI (Dacarbazine) RN - 9007-92-5 (Glucagon) SB - IM MH - Adenoma, Islet Cell/*therapy MH - Body Weight MH - Dacarbazine/*therapeutic use MH - Dermatitis/diagnosis MH - Diabetes Mellitus/diagnosis MH - Glucagon/blood MH - Glucagonoma/diagnosis/*therapy MH - Humans MH - Male MH - Middle Aged MH - *Pancreatectomy MH - Pancreatic Neoplasms/diagnosis/*therapy MH - Scotoma/diagnosis MH - Syndrome EDAT- 1981/10/01 00:00 MHDA- 1981/10/01 00:01 CRDT- 1981/10/01 00:00 PHST- 1981/10/01 00:00 [pubmed] PHST- 1981/10/01 00:01 [medline] PHST- 1981/10/01 00:00 [entrez] PST - ppublish SO - Surgery. 1981 Oct;90(4):713-9. PMID- 39884690 OWN - NLM STAT- MEDLINE DCOM- 20250130 LR - 20250130 IS - 0301-2603 (Print) IS - 0301-2603 (Linking) VI - 53 IP - 1 DP - 2025 Jan TI - [Lateral Lumbar Interbody Fusion(XLIF & OLIF):Indications, X-ray Fluoroscopy-guided and 3D-CT Spinal Navigation Techniques, and Safe Surgical Practices to Prevent Complications]. PG - 102-122 LID - 10.11477/mf.030126030530010102 [doi] AB - Lateral lumbar interbody fusion(LLIF), including extreme lateral interbody fusion(XLIF) and oblique lateral interbody fusion(OLIF), constitute a treatment option for many lumbar disorders that predominantly cause degenerative disc disease. LLIF is beneficial for managing conditions, such as lumbar spondylolisthesis, degenerative disc disease, and adult spinal deformities. LLIF is preferred for enabling indirect decompression of the spinal canal and nerve root foramen, without inducing immediate postoperative damage to the peri-vertebral tissues. To minimize the risk of lumbosacral plexopathy, neuromonitoring and X-ray fluoroscopy are routinely used, and can confer significant radiation exposure on surgeons and surgical staff. Intraoperative imaging-guided spinal navigation during LLIF increases accuracy and reduces radiation exposure. Nonetheless, the risk of serious LLIF-associated complications, such as lumbosacral plexopathy, vascular problems, ureteral damage, and intestinal damage, warrant a precise preoperative plan. To improve the operative safety of LLIF, this report elucidates the procedural details of XLIF and OLIF and highlights the potential pitfalls of LLIF. FAU - Itoh, Yasunobu AU - Itoh Y AD - Department of Neurosurgery, Tokyo General Hospital. FAU - Kitagawa, Ryo AU - Kitagawa R FAU - Numazawa, Shinichi AU - Numazawa S FAU - Kanazawa, Ryuzaburo AU - Kanazawa R FAU - Kono, Takao AU - Kono T FAU - Watanabe, Sadayoshi AU - Watanabe S LA - jpn PT - English Abstract PT - Journal Article PL - Japan TA - No Shinkei Geka JT - No shinkei geka. Neurological surgery JID - 0377015 SB - IM MH - Humans MH - *Spinal Fusion/methods MH - Fluoroscopy MH - *Lumbar Vertebrae/surgery/diagnostic imaging MH - *Postoperative Complications/prevention & control MH - Tomography, X-Ray Computed MH - Imaging, Three-Dimensional EDAT- 2025/01/31 00:20 MHDA- 2025/01/31 00:21 CRDT- 2025/01/30 20:32 PHST- 2025/01/31 00:21 [medline] PHST- 2025/01/31 00:20 [pubmed] PHST- 2025/01/30 20:32 [entrez] AID - 030126030530010102 [pii] AID - 10.11477/mf.030126030530010102 [doi] PST - ppublish SO - No Shinkei Geka. 2025 Jan;53(1):102-122. doi: 10.11477/mf.030126030530010102. PMID- 10366945 OWN - NLM STAT- MEDLINE DCOM- 19990701 LR - 20161020 IS - 0869-8031 (Print) IS - 0869-8031 (Linking) VI - 39 IP - 2-3 DP - 1999 Mar-Jun TI - [Strategy and tactics of radiation protection of the personnel in light of future work on stabilization and reorganization of the "Shelter" compound into radiologically safe system]. PG - 227-37 AB - The research aim is to analyze the "Shelter" personnel work conditions and to estimate how these conditions specify radiological defense. "Shelter" object remains to be an accumulation of the open radiotoxic materials. It is expected that the usage of standard technologies in such conditions will be connected with the great dose-expense of external and internal irradiation. The significant quantity of the fuel dust (more 30 tonne according to uranium) and the extremely harmful microclimate conditions such as: aggressive radiochemical aerosols, exclusively artificial and obviously insufficient illumination, high humidity, discomfortable temperature regime, high ability of many working places to induce the emotional stress reaction in personnel are the specificity of "Shelter" object. The synergetic influence of radiofactor and "Shelter" object microclimate is very dangerous because of its ability to deteriorate significantly the personnel health up to acute stress reaction. In these cases there appear the episodes of the short disorders of orientation in the surrounding situation, paroxysmal consciousness disturbances which may become the nondirect reason of the overirradiation and growth of work traumatism. That's why the methods of the stress-reaction prophylaxis and improvement of the individual defense become extremely improvement for the "Shelter" object personnel. It was shown that the following medicines are perspective due to their adaptogenic and radioprotective abilities, such as: alpha-2-recombinant interferon, antiinflammatory, steroid, antioxidant and enterosorbtive preparations of biological nature. FAU - Seniuk, O F AU - Seniuk OF AD - ISTC Shelter NAcSci of Ukraine, Chernobyl. FAU - Danilov, V M AU - Danilov VM LA - rus PT - English Abstract PT - Journal Article TT - Strategiia i taktika radiologicheskoĭ zashchity personala v sviazi s predstoiashchimi rabotami po stabilizatsii i reorganizatsii ob''ekta "Ukrytie" v radiatsionno bezopasnuiu sistemu. PL - Russia (Federation) TA - Radiats Biol Radioecol JT - Radiatsionnaia biologiia, radioecologiia JID - 9317212 RN - 0 (Radiation-Protective Agents) SB - IM MH - Humans MH - *Power Plants MH - Radiation Dosage MH - *Radiation Protection/economics MH - Radiation-Protective Agents/therapeutic use MH - *Radioactive Hazard Release MH - Safety MH - Ukraine EDAT- 1999/06/15 00:00 MHDA- 1999/06/15 00:01 CRDT- 1999/06/15 00:00 PHST- 1999/06/15 00:00 [pubmed] PHST- 1999/06/15 00:01 [medline] PHST- 1999/06/15 00:00 [entrez] PST - ppublish SO - Radiats Biol Radioecol. 1999 Mar-Jun;39(2-3):227-37. PMID- 20572406 OWN - NLM STAT- MEDLINE DCOM- 20100727 LR - 20100624 IS - 0094-6354 (Print) IS - 0094-6354 (Linking) VI - 78 IP - 3 DP - 2010 Jun TI - Caudal anesthesia in a patient with severe pulmonary hypertension. PG - 202-6 AB - Delivery of anesthesia to patients with severe pulmonary hypertension can be extremely challenging. The profound hemodynamic alterations of the disease can often be exacerbated by alterations in circulatory function brought about by anesthetic and surgical interventions. High perioperative morbidity and mortality rates have been reported. Minimizing adverse outcomes in these patients requires careful perioperative evaluation and planning. Selection of an anesthetic technique suitable for the surgery without causing major hemodynamic alterations, which can lead to cardiac failure and death, is a unique consideration of the anesthesia provider. As shown in this case report, caudal anesthesia, when appropriate, can offer a safe anesthetic for these patients. FAU - Ly, Doanh T AU - Ly DT AD - University of California, San Francisco, USA. doanh1H@yahoo.com LA - eng PT - Case Reports PT - Journal Article PL - United States TA - AANA J JT - AANA journal JID - 0431420 MH - Adult MH - *Anesthesia, Caudal/methods/nursing MH - Condylomata Acuminata/complications/*surgery MH - Feedback, Physiological MH - Hemodynamics MH - Humans MH - Hypertension, Pulmonary/classification/*complications/physiopathology MH - Male MH - *Monitoring, Intraoperative/methods/nursing MH - *Nurse Anesthetists/organization & administration MH - Patient Positioning MH - Patient Selection MH - Rectal Diseases/complications/*surgery MH - Risk Factors MH - Safety MH - Severity of Illness Index EDAT- 2010/06/25 06:00 MHDA- 2010/07/28 06:00 CRDT- 2010/06/25 06:00 PHST- 2010/06/25 06:00 [entrez] PHST- 2010/06/25 06:00 [pubmed] PHST- 2010/07/28 06:00 [medline] PST - ppublish SO - AANA J. 2010 Jun;78(3):202-6. PMID- 12678118 OWN - NASA STAT- MEDLINE DCOM- 20030731 LR - 20061115 IS - 0075-9422 (Print) IS - 0075-9422 (Linking) VI - 14 DP - 1976 TI - Effect of extreme factors on micro-organisms used for the control of the effectiveness of sterilization. PG - 337-9 AB - Survival of micro-organisms used for control of sterilization procedures was studied under conditions simulating the Martian environment (daily temperature change from +20 degrees to -20 degrees in 99.98% CO2 + 0.02% air at 0.13 x 10(-6) N m-2 pressure, with ultraviolet radiation spanning the whole range of the solar spectrum 300-350 MkW cm-2). The test organisms were four strains of Bacillus subtilis and one strain of Bacillus anthracoides, and were inoculated on to four materials, smooth metal, porous plastic, multilayer composition material and powdered limonite. Some organisms survived on all materials, the greatest on the limonite. The resistance of the survivors to disinfectants was the same as that of the original cultures. FAU - Vashkov, V I AU - Vashkov VI AD - All-Union Scientific Research Institute for Disinfection & Sterilization, Moscow, USSR. FAU - Scheglova, G V AU - Scheglova GV FAU - Ramkova, N V AU - Ramkova NV FAU - Zavolnaya, E S AU - Zavolnaya ES FAU - Fedorova, K O AU - Fedorova KO FAU - Skvortsova, E K AU - Skvortsova EK LA - eng PT - Comparative Study PT - Journal Article PL - Netherlands TA - Life Sci Space Res JT - Life sciences and space research JID - 1250331 RN - 0 (Disinfectants) MH - Bacillus/*growth & development/radiation effects MH - Bacillus subtilis/*growth & development/radiation effects MH - Containment of Biohazards MH - Disinfectants MH - *Environmental Microbiology MH - Extraterrestrial Environment MH - *Mars MH - *Sterilization MH - *Ultraviolet Rays OID - NASA: 00029155 EDAT- 1976/01/01 00:00 MHDA- 2003/08/02 05:00 CRDT- 1976/01/01 00:00 PHST- 1976/01/01 00:00 [pubmed] PHST- 2003/08/02 05:00 [medline] PHST- 1976/01/01 00:00 [entrez] PST - ppublish SO - Life Sci Space Res. 1976;14:337-9. PMID- 12577553 OWN - NLM STAT- MEDLINE DCOM- 20030430 LR - 20061115 IS - 0042-4625 (Print) IS - 0042-4625 (Linking) VI - 161 IP - 4 DP - 2002 TI - [Preservation of the components of blood and bone marrow for autotransfusion in patients of a particular risk contingent]. PG - 47-51 AB - Cryopreservation is the method of choice in solution of the problem of the done in good time reservation of the components of blood and bone marrow for autotransfusion in patients referred to the contingent of particular risk. Freezing of autologous hemocomponents increases the infection safety and efficiency of therapy with hemocomponents. The wide introduction of using autologous hemocomponents into the everyday surgical practice and in the arsenal of means and methods of the medicine of extreme situations is an indispensable condition for increasing the effects of curative and medico-evacuational measures. FAU - Vil'ianinov, V N AU - Vil'ianinov VN FAU - Bagautdinov, Sh M AU - Bagautdinov ShM FAU - Kaleko, S P AU - Kaleko SP FAU - Sidorkevich, S V AU - Sidorkevich SV FAU - Petrenko, G I AU - Petrenko GI FAU - Zhiburt, E B AU - Zhiburt EB LA - rus PT - Comparative Study PT - English Abstract PT - Journal Article TT - Rezervirovanie dlia autotransfuziĭ komponentov krovi i kostnogo mozga liudeĭ iz kontingentov osobogo riska. PL - Russia (Federation) TA - Vestn Khir Im I I Grek JT - Vestnik khirurgii imeni I. I. Grekova JID - 0411377 SB - IM MH - *Blood Banks MH - *Blood Component Transfusion MH - *Blood Preservation MH - *Blood Transfusion, Autologous MH - *Bone Marrow MH - *Cryopreservation MH - Emergencies MH - Humans MH - *Organ Preservation MH - Risk Factors MH - Time Factors EDAT- 2003/02/13 04:00 MHDA- 2003/05/06 05:00 CRDT- 2003/02/13 04:00 PHST- 2003/02/13 04:00 [pubmed] PHST- 2003/05/06 05:00 [medline] PHST- 2003/02/13 04:00 [entrez] PST - ppublish SO - Vestn Khir Im I I Grek. 2002;161(4):47-51. PMID- 1842978 OWN - NLM STAT- MEDLINE DCOM- 19930204 LR - 20180213 IS - 1011-6125 (Print) IS - 1011-6125 (Linking) VI - 57 IP - 4 DP - 1991 TI - Stereotactic Aqua-Stream and Aspirator in the treatment of intracerebral hematoma. An experimental study. PG - 221-7 AB - The efficacy of the Stereotactic Aqua-Stream and Aspirator (SAS&A) was experimentally investigated by using hematoma models in the test tube and in gelatin. Even a solid hematoma can be crushed by the water jet and aspirated easily. The greater the positive pressure of the water jet and the negative pressure of suction, the stronger the ability to remove clots. A water jet pressure of 10-20 kg/cm2 and a suction pressure of 100-200 mm Hg were sufficient to remove experimental clots from the test vessels. When the SAS&A was operated in the brain of dogs with a water jet pressure of 20 kg/cm2 and a suction pressure of 200 mm Hg, aspirated brain tissue was less than 15 mg/min in weight, and histological brain injuries were observed only in the area less than 2 mm from the window of the probe, indicating that the procedure with the SAS&A would be relatively atraumatic. We conclude that these observations indicate that the SAS&A can be safe and extremely useful for removal of hypertensive intracerebral hematomas, even in the acute stage. FAU - Mukai, H AU - Mukai H AD - Department of Neurosurgery, Kanazawa University, Japan. FAU - Yamashita, J AU - Yamashita J FAU - Kitamura, A AU - Kitamura A FAU - Ito, H AU - Ito H LA - eng PT - Journal Article PL - Switzerland TA - Stereotact Funct Neurosurg JT - Stereotactic and functional neurosurgery JID - 8902881 SB - IM MH - Animals MH - Cerebral Hemorrhage/*therapy MH - Disease Models, Animal MH - Dogs MH - Hematoma/*therapy MH - Safety MH - Stereotaxic Techniques/*instrumentation MH - Suction/adverse effects/*instrumentation/methods MH - Therapeutic Irrigation/adverse effects/*instrumentation/methods EDAT- 1991/01/01 00:00 MHDA- 1991/01/01 00:01 CRDT- 1991/01/01 00:00 PHST- 1991/01/01 00:00 [pubmed] PHST- 1991/01/01 00:01 [medline] PHST- 1991/01/01 00:00 [entrez] AID - 10.1159/000099572 [doi] PST - ppublish SO - Stereotact Funct Neurosurg. 1991;57(4):221-7. doi: 10.1159/000099572. PMID- 22788083 OWN - NLM STAT- MEDLINE DCOM- 20120910 LR - 20120713 IS - 0004-4849 (Print) IS - 0004-4849 (Linking) VI - 104 IP - 1 DP - 2012 Jan-Mar TI - Anesthetic implications of two genetic translocation (6p21; 6p13) in a patient with history of congenital varicella syndrome: a case report. PG - 64-8 AB - The coexistence of multiple chromosomal abnormalities and Congenital Varicella Syndrome (CVS) in one patient is a rare event in which anesthetic implications should be considered. This case report describes a 9-year-old female with CVS and a karyotype analysis of 6p21; 16p13 genetic translocations. We conducted a detailed investigation of the consequences of such findings and the potential outcomes in anesthesia of this uncommon incident including thorough research on the characteristics present in each condition. We concluded that: (1) coexistence of two genetic translocations (6p21; 16p13) in one patient, and simultaneously with CVS is undoubtedly an extremely rare event; (2) difficult airway management, potential cardiac dysfunction, risk of pulmonary aspiration, fluid disturbances, and a hard to access peripheral vascularity are among the most important anesthetic implications as a consequence of having all these disorders; (3) ketamine was a safety and efficacious option for sedation during fiber optic bronchoscopy. FAU - Creagh, Osmar AU - Creagh O AD - Department of Anesthesiology, University of Puerto Rico, Puerto Rico. osmarcb@yahoo.es FAU - Torres, Hector AU - Torres H FAU - Rivera, Karinés AU - Rivera K FAU - Hernández-Arroyo, César AU - Hernández-Arroyo C FAU - González, Maria AU - González M FAU - Rivera, Alberto AU - Rivera A LA - eng PT - Case Reports PT - Journal Article PL - Puerto Rico TA - Bol Asoc Med P R JT - Boletin de la Asociacion Medica de Puerto Rico JID - 7505267 SB - IM MH - *Anesthesia MH - Chickenpox/*congenital/*genetics MH - Child MH - Female MH - Humans MH - Syndrome MH - *Translocation, Genetic EDAT- 2012/07/14 06:00 MHDA- 2012/09/11 06:00 CRDT- 2012/07/14 06:00 PHST- 2012/07/14 06:00 [entrez] PHST- 2012/07/14 06:00 [pubmed] PHST- 2012/09/11 06:00 [medline] PST - ppublish SO - Bol Asoc Med P R. 2012 Jan-Mar;104(1):64-8. PMID- 9148338 OWN - NLM STAT- MEDLINE DCOM- 19970512 LR - 20190905 IS - 0037-8682 (Print) IS - 0037-8682 (Linking) VI - 30 IP - 2 DP - 1997 Mar-Apr TI - [Inactivated vaccine against hepatitis A: review of the literature and considerations on its use]. PG - 145-57 AB - A new, safe, highly immunogenic and probably long term effective inactivated hepatitis A virus vaccine has been licensed for clinical use. Clinical trials in developed countries have demonstrated its efficacy in preventing hepatitis A in high risk groups, such as travelers to regions where HAV infection is endemic and day care children and staff, its efficacy in postexposure conditions and in community outbreaks. The authors review the basic and changing features of the disease and its epidemiology in specific geographical regions trying to elucidate its use in the control of the disease in developing countries, especially in Brazil. Taking in consideration its efficacy, safety and immunogenicity, the inactivated hepatitis A vaccine may be of extreme value in terms of individual protection. Because this vaccine is so new, there are no formal recommendations for its use in developing countries, and appropriate public health use of hepatitis A vaccine requires up-to-date epidemiological information. FAU - Santos, M V AU - Santos MV AD - Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, Brasil. FAU - Lopes, M H AU - Lopes MH LA - por PT - English Abstract PT - Journal Article TT - Vacina inativada contra a hepatite A: revisão da literatura e considerações sobre seu uso. PL - Brazil TA - Rev Soc Bras Med Trop JT - Revista da Sociedade Brasileira de Medicina Tropical JID - 7507456 RN - 0 (Hepatitis A Vaccines) RN - 0 (Vaccines, Inactivated) RN - 0 (Viral Hepatitis Vaccines) SB - IM MH - Developing Countries MH - Global Health MH - Hepatitis A/epidemiology/*prevention & control/therapy MH - Hepatitis A Vaccines MH - Humans MH - Immunotherapy, Active MH - Seroepidemiologic Studies MH - Vaccines, Inactivated/therapeutic use MH - Viral Hepatitis Vaccines/*therapeutic use EDAT- 1997/03/01 00:00 MHDA- 1997/03/01 00:01 CRDT- 1997/03/01 00:00 PHST- 1997/03/01 00:00 [pubmed] PHST- 1997/03/01 00:01 [medline] PHST- 1997/03/01 00:00 [entrez] AID - 10.1590/s0037-86821997000200010 [doi] PST - ppublish SO - Rev Soc Bras Med Trop. 1997 Mar-Apr;30(2):145-57. doi: 10.1590/s0037-86821997000200010. PMID- 9501634 OWN - NLM STAT- MEDLINE DCOM- 19980402 LR - 20161205 IS - 0004-1254 (Print) IS - 0004-1254 (Linking) VI - 48 IP - 3 DP - 1997 Sep TI - [Problems in determining the occupational etiology of liver damage]. PG - 319-22 AB - Workplaces involving the use of hepatotoxic substances are classified as workplaces with hazardous and/or special working conditions. Rules and Regulations for Workplaces with Special Working Conditions refer to safety measures to be observed both by the workers at such workplaces and by their employers. This paper presents the cases of plaster moulds casters occupationally exposed to chlorine carbohydrates. The employer did not classify those workplaces as workplaces with special working conditions. Liver damage was found in five (of 12) workers. After further examination, two of the five workers were diagnosed to suffer from occupational liver damage. Unable to confirm the etiology of the liver damage, however, a committee appointed for determining occupational disability did not recognize the disease of the two workers as occupational. This example shows the necessity to introduce and perform strict control of technological processes and working conditions. At the same time, accurate assessment of the danger present at the workplace requires preliminary and periodical examination of the workers. This is extremely important today when the necessity of performing such examinations is frequently disputed. It is expected that the compulsory health insurance for occupational diseases imposed on employers will eventually bring medical examination to the deserved place. FAU - Brkić, J AU - Brkić J LA - hrv PT - Case Reports PT - Journal Article TT - Teskoće pri ocjeni profesionalne etiologije ostećenja jetre. PL - Croatia TA - Arh Hig Rada Toksikol JT - Arhiv za higijenu rada i toksikologiju JID - 0373100 RN - 0 (Hydrocarbons, Chlorinated) SB - IM MH - *Chemical and Drug Induced Liver Injury MH - Humans MH - Hydrocarbons, Chlorinated/*adverse effects MH - Liver Diseases/diagnosis MH - Male MH - Middle Aged MH - Occupational Diseases/*chemically induced/diagnosis EDAT- 1998/03/21 00:00 MHDA- 1998/03/21 00:01 CRDT- 1998/03/21 00:00 PHST- 1998/03/21 00:00 [pubmed] PHST- 1998/03/21 00:01 [medline] PHST- 1998/03/21 00:00 [entrez] PST - ppublish SO - Arh Hig Rada Toksikol. 1997 Sep;48(3):319-22. PMID- 11248852 OWN - NLM STAT- MEDLINE DCOM- 20010621 LR - 20191210 IS - 1868-596X (Print) IS - 1868-596X (Linking) VI - 18 IP - 1 DP - 2001 TI - [Development of a novel influenza vaccine derived from a continuous cell line]. PG - 50-4 AB - Influenza viruses for production are presently produced in embryonated hen"s eggs. This conventional standard methodology is extremely cumbersome; it requires millions of eggs and an extensive purification to reduce the amount of contaminating egg proteins and to minimise the risk of allergies against egg albumin. The shortage of eggs in a pandemic situation, the selection of egg-adapted variants and the presence of adventitious viruses has emphasised the necessity for production of Influenza vaccines on a well characterised stable cell line. Our established serum and protein free Vero cell technology has been successfully adapted to large scale production of a huge variety of Influenza virus strains. The production in 1200 liter fermenter cultures under serum free conditions gave antigen yields comparable to the conventional embryonated egg technology. The development of a rapid and efficient purification scheme resulted in a safe high purity vaccine which was at least as immunogenic as conventional egg-derived vaccines in a mouse model. Clinical trials in the UK, Poland and Austria demonstrated that the Vero cell derived influenza vaccine is well tolerated, safe and highly immunogenic in humans. FAU - Kistner, O AU - Kistner O AD - Biomedical Research Center, Baxter Vaccine AG, A-Orth/Donau. Otfried_Kistner@baxter.com FAU - Barrett, N AU - Barrett N FAU - Mundt, W AU - Mundt W FAU - Reiter, M AU - Reiter M FAU - Schober-Bendixen, S AU - Schober-Bendixen S FAU - Eder, G AU - Eder G FAU - Dorner, F AU - Dorner F LA - ger PT - Journal Article TT - Entwicklung eines neuen, aus permanenten Zellen gewonnenen Grippe-Impfstoffes. PL - Germany TA - ALTEX JT - ALTEX JID - 100953980 RN - 0 (Culture Media, Serum-Free) RN - 0 (Influenza Vaccines) SB - IM MH - Animals MH - Cell Culture Techniques/methods MH - Chlorocebus aethiops MH - Clinical Trials as Topic MH - Culture Media, Serum-Free MH - Eggs MH - Humans MH - Influenza A virus/growth & development MH - Influenza B virus/growth & development MH - Influenza Vaccines/*biosynthesis/therapeutic use MH - Safety MH - Vero Cells EDAT- 2001/03/15 10:00 MHDA- 2001/06/22 10:01 CRDT- 2001/03/15 10:00 PHST- 2001/03/15 10:00 [pubmed] PHST- 2001/06/22 10:01 [medline] PHST- 2001/03/15 10:00 [entrez] PST - ppublish SO - ALTEX. 2001;18(1):50-4. PMID- 3691962 OWN - NLM STAT- MEDLINE DCOM- 19880129 LR - 20031114 IS - 0301-5149 (Print) IS - 0301-5149 (Linking) VI - 68 DP - 1987 TI - The approach used to establish the safety of veterinary vaccines produced in the BHK 21 cell line. PG - 19-25 AB - A unique feature of the BHK 21 system is that the hamster provides a readily available and extremely sensitive (5, 13) assay system for process validation assays (Table IV outlines a production control scheme) since only between 5 and 100 cells are needed for tumors to form. While it was argued on theoretical grounds that a transforming agent active in a target species would not necessarily induce transformation in hamsters, clinical evidence has shown that the tumorigenicity of BHK 21 cells is a whole cell phenomenon. The main points to be drawn from the work with BHK 21/13 cells are as follows: 1. Cell culture technology now allows standardized, safe, effective, economical, large-scale vaccine production. 2. Although intact BHK 21 cells have been shown to be tumorigenic in hamsters, which is the species of origin for the cell line, no tumorigenic activity has been demonstrated in a variety of other aspects. 3. Even in hamsters, BHK 21 cells must be intact to cause tumor growth, a condition which can easily be avoided in biologicals production. 4. Decisions on the acceptability of a cell like the BHK 21 line were made on the basis of multiple species studies and validation of the manufacturing process to show that the final product was free of biologically active contaminants. FAU - Regan, P J AU - Regan PJ AD - World Health Organization, Geneva, Switzerland. FAU - Petricciani, J C AU - Petricciani JC LA - eng PT - Journal Article PL - Switzerland TA - Dev Biol Stand JT - Developments in biological standardization JID - 0427140 RN - 0 (Viral Vaccines) SB - IM MH - Animals MH - Cell Line MH - Quality Control MH - Safety MH - Vaccination/*veterinary MH - Viral Vaccines/*standards MH - Virus Diseases/prevention & control/*veterinary EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] PST - ppublish SO - Dev Biol Stand. 1987;68:19-25. PMID- 6469176 OWN - NLM STAT- MEDLINE DCOM- 19840928 LR - 20131121 IS - 0015-8178 (Print) IS - 0015-8178 (Linking) VI - 102 IP - 23 DP - 1984 Jun 21 TI - [Acute treatment of severe cardiogenic pulmonary edema. Effect and tolerability of ISDN as bolus and continuous infusion]. PG - 647-52 AB - Isosorbide dinitrate (ISDN) was administered intravenously to 21 patients with severe cardiogenic pulmonary edema. In 15 cases the condition was due to coronary heart disease (3 of them had arterial hypertension additionally), and 3 patients due to cardiomyopathy. In the remaining 3 valvular disorders were prevailing. The ISDN solution was administered as an i.v. bolus followed by continuous i.v. injection from an automatic perfusion device. Oxygen, furosemide, and in some cases digitalis were given in addition. Monitoring consisted of clinical surveillance, blood gas analyses, and repeated X-ray control. The results obtained confirm the efficacy and safety of this mode of ISDN administration. This applies particularly for patients in whose therapy is aimed at fast control of life-threatening hypoxia. Despite extreme asphyxia, only three patients needed artificial respiration, one died in cardiogenic shock, while all others were rapidly improved. It could thus be demonstrated that this type of therapy may be safely and efficiently handled by careful clinical supervision, without invasive hemodynamic monitoring. FAU - Harf, C AU - Harf C FAU - Welter, R AU - Welter R LA - ger PT - English Abstract PT - Journal Article TT - Die Akutbehandlung des schweren kardialen Lungenödems. Wirksamkeit und Verträglichkeit von ISDN als Bolus und als Dauerinfusion. PL - Germany TA - Fortschr Med JT - Fortschritte der Medizin JID - 2984763R RN - IA7306519N (Isosorbide Dinitrate) SB - IM MH - Acute Disease MH - Aged MH - Blood Pressure/drug effects MH - Drug Tolerance MH - Female MH - Heart Diseases/*complications MH - Heart Rate/drug effects MH - Humans MH - Infusions, Parenteral MH - Injections, Intravenous MH - Isosorbide Dinitrate/*administration & dosage/pharmacology MH - Male MH - Middle Aged MH - Pulmonary Edema/*drug therapy/etiology EDAT- 1984/06/21 00:00 MHDA- 1984/06/21 00:01 CRDT- 1984/06/21 00:00 PHST- 1984/06/21 00:00 [pubmed] PHST- 1984/06/21 00:01 [medline] PHST- 1984/06/21 00:00 [entrez] PST - ppublish SO - Fortschr Med. 1984 Jun 21;102(23):647-52. PMID- 12750911 OWN - NLM STAT- MEDLINE DCOM- 20031112 LR - 20081121 IS - 0937-4477 (Print) IS - 0937-4477 (Linking) VI - 260 IP - 5 DP - 2003 May TI - Protection from epistaxis blood aerosol contamination: a novel use of a surgical facemask. PG - 242-3 AB - Epistaxis is one of the most common otorhinolaryngological emergencies. It is also one of the most common emergencies that places medical staff at risk of blood contamination. We report a simple yet extremely effective method in which a standard surgical facemask is worn by the patient, thereby reducing blood aerosol contamination without interfering with effective management. FAU - Hassan, M Shahbaz AU - Hassan MS AD - Department of Ear, Nose and Throat and Head and Neck Surgery, University Hospital Birmingham, Queen Elizabeth, Edgbaston, Birmingham B15 2TH, UK. shahbazhassan@hotmail.com FAU - Trotter, MatthewM I AU - Trotter MI LA - eng PT - Journal Article DEP - 20021122 PL - Germany TA - Eur Arch Otorhinolaryngol JT - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JID - 9002937 RN - 0 (Aerosols) SB - IM MH - Aerosols/adverse effects MH - Communicable Disease Control/instrumentation MH - Communicable Diseases/etiology MH - Containment of Biohazards/*instrumentation MH - Epistaxis/*complications MH - Humans MH - Infectious Disease Transmission, Patient-to-Professional/methods/*prevention & control MH - *Masks EDAT- 2003/05/17 05:00 MHDA- 2003/11/13 05:00 CRDT- 2003/05/17 05:00 PHST- 2002/04/24 00:00 [received] PHST- 2002/06/12 00:00 [accepted] PHST- 2003/05/17 05:00 [pubmed] PHST- 2003/11/13 05:00 [medline] PHST- 2003/05/17 05:00 [entrez] AID - 10.1007/s00405-002-0510-x [doi] PST - ppublish SO - Eur Arch Otorhinolaryngol. 2003 May;260(5):242-3. doi: 10.1007/s00405-002-0510-x. Epub 2002 Nov 22. PMID- 37314094 OWN - NLM STAT- MEDLINE DCOM- 20230728 LR - 20230728 IS - 1558-5646 (Electronic) IS - 0014-3820 (Linking) VI - 77 IP - 8 DP - 2023 Jul 27 TI - When does natural selection take place? PG - 1739-1743 LID - 10.1093/evolut/qpad108 [doi] AB - Although many studies of form and function find a correlation between performance and adaptive specialization, others fail to discern such a tight link despite careful monitoring and observation. This inconsistency among studies raises the question of when, how often, and how effectively natural selection and the organism's own activities operate to maintain or improve the adapted state. I suggest here that most organisms operate well within the limits of their capacities (safety factors) most of the time and that interactions and circumstances that cause natural selection and test the body's limits come in discrete, intermittent events rather than as continuously present or chronic conditions. Everyday life without such events does not test performance limits and therefore does not usually result in natural selection. This perspective on selection as rare, intermittent testing by ecological agencies suggests that studies of selective processes and activity in the wild should focus on observing and measuring the intensity and frequency of selective events and responses, intense challenges stemming from agencies such as predators, competitors, mating-related rituals, and extreme weather. CI - © The Author(s) 2023. Published by Oxford University Press on behalf of The Society for the Study of Evolution (SSE). All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Vermeij, Geerat J AU - Vermeij GJ AUID- ORCID: 0000-0002-6450-5687 AD - Department of Earth and Planetary Sciences, University of California, Davis, CA, United States. LA - eng PT - Journal Article PL - United States TA - Evolution JT - Evolution; international journal of organic evolution JID - 0373224 SB - IM MH - *Reproduction MH - *Selection, Genetic MH - Adaptation, Physiological OTO - NOTNLM OT - agency OT - natural selection OT - safety factors EDAT- 2023/06/14 13:07 MHDA- 2023/07/28 06:42 CRDT- 2023/06/14 08:13 PHST- 2023/04/06 00:00 [received] PHST- 2023/05/31 00:00 [revised] PHST- 2023/06/12 00:00 [accepted] PHST- 2023/07/28 06:42 [medline] PHST- 2023/06/14 13:07 [pubmed] PHST- 2023/06/14 08:13 [entrez] AID - 7197683 [pii] AID - 10.1093/evolut/qpad108 [doi] PST - ppublish SO - Evolution. 2023 Jul 27;77(8):1739-1743. doi: 10.1093/evolut/qpad108. PMID- 12167065 OWN - NLM STAT- MEDLINE DCOM- 20021114 LR - 20181113 IS - 0114-5916 (Print) IS - 0114-5916 (Linking) VI - 25 IP - 10 DP - 2002 TI - How safe is emergency contraception? PG - 695-706 AB - Emergency contraception is used to prevent pregnancy after unprotected sex but before pregnancy begins. Currently, women can use emergency contraception by taking higher doses of the active ingredients found in ordinary oral contraceptive pills [either combined estrogen-progestogen (progestin) or progestogen-only formulations], or by having providers insert copper-bearing intrauterine devices (IUDs). The antiprogestogen mifepristone also has an excellent efficacy and safety profile as emergency contraception, but it is currently available for this indication only in China. Many studies have documented providers' and women's fears about the individual and public health safety risks of emergency contraception. Some of these concerns include potentially increased risks of cardiovascular events (including arterial and venous disease), worries about possible effects on future fertility, feared teratogenic consequences following method failure or inadvertent use during pregnancy, exaggerated or extreme fears of adverse tolerability, and concerns about drug interactions with other medications. Wider public health questions include feared reductions in the use of ongoing, more effective contraception, possible 'abuse' of emergency contraception through overly frequent use, and potential increases in risky sexual encounters (owing to the existence of a back-up, postcoital method) and therefore in rates of sexually transmitted infections, including HIV/AIDS. These fears can each be generally allayed. Direct and indirect investigations of emergency contraception in the biomedical and social science literature, the extensively documented safety profile of ordinary oral contraceptives, and more than 30 years of clinical experience since hormonal emergency contraception was first described, give strong evidence for its safety. This review confirms declarations by the World Health Organization and the US Food and Drug Administration, and shows that emergency contraception has an excellent safety profile in nearly all women. Finally, emergency contraception allows women a second chance to avoid unwanted pregnancies. Whether pregnancy is carried to term or terminated, the condition has inherent risks that are greater than any posed by emergency contraception. FAU - Norris Turner, Abigail AU - Norris Turner A AD - Regional Program Manager, Population Council, Mexico City, Mexico. anorristurner@hotmail.com FAU - Ellertson, Charlotte AU - Ellertson C LA - eng PT - Journal Article PL - New Zealand TA - Drug Saf JT - Drug safety JID - 9002928 RN - 0 (Contraceptives, Oral, Combined) RN - 0 (Contraceptives, Postcoital) RN - 0 (Estrogens) RN - 0 (Progestins) RN - 320T6RNW1F (Mifepristone) SB - IM EIN - Drug Saf 2002;25(11):758 MH - Congenital Abnormalities/etiology MH - Contraceptives, Oral, Combined/administration & dosage/adverse effects MH - Contraceptives, Postcoital/*administration & dosage/*adverse effects MH - Drug Administration Schedule MH - Drug Interactions MH - Estrogens/administration & dosage/adverse effects MH - Female MH - Fertility MH - Humans MH - Intrauterine Devices, Copper/*adverse effects MH - Mifepristone/administration & dosage/adverse effects MH - Pregnancy MH - Progestins/administration & dosage/adverse effects MH - Public Health MH - Risk Assessment MH - Sexually Transmitted Diseases/epidemiology/etiology MH - United States MH - United States Food and Drug Administration MH - World Health Organization EDAT- 2002/08/09 10:00 MHDA- 2002/11/26 04:00 CRDT- 2002/08/09 10:00 PHST- 2002/08/09 10:00 [pubmed] PHST- 2002/11/26 04:00 [medline] PHST- 2002/08/09 10:00 [entrez] AID - 251002 [pii] AID - 10.2165/00002018-200225100-00002 [doi] PST - ppublish SO - Drug Saf. 2002;25(10):695-706. doi: 10.2165/00002018-200225100-00002. PMID- 36066638 OWN - NLM STAT- MEDLINE DCOM- 20220908 LR - 20220916 IS - 0748-8157 (Print) IS - 0748-8157 (Linking) VI - 39 IP - 1 DP - 2022 Oct 1 TI - Climate Change and Healthcare: A Complicated Relationship. PG - 4-10 LID - 10.1097/HAP.0000000000000148 [doi] AB - Climate change is a crisis with a devastating impact on health. The warming atmosphere is increasing the tolls of deaths and illnesses from heat waves, extreme weather, poor air quality, insect-borne diseases, and other conditions. Healthcare is connected to climate change in a way that is not fully appreciated by many healthcare leaders-in fact, the sector generates a significant share of greenhouse gas emissions that cause climate change. As additional costs, healthcare providers' margins are put at risk from treating more climate-related disease and illness, supply chain disruptions, and damage from severe storms and wildfires. These connections provide a compelling rationale for healthcare executives to create more resilience in operations, lead efforts toward decarbonization, and catalyze for climate action. CI - Copyright © 2022 Foundation of the American College of Healthcare Executives. FAU - Gerwig, Kathy AU - Gerwig K AD - Kathy Gerwig is a strategic adviser on climate and health and formerly vice president, employee safety, health and wellness, and environmental stewardship officer at Kaiser Permanente based in Oakland, California. LA - eng PT - Journal Article PL - United States TA - Front Health Serv Manage JT - Frontiers of health services management JID - 8501389 MH - *Climate Change MH - Delivery of Health Care MH - *Health Facilities COIS- The author declares no conflicts of interest. EDAT- 2022/09/07 06:00 MHDA- 2022/09/09 06:00 CRDT- 2022/09/06 11:15 PHST- 2022/09/06 11:15 [entrez] PHST- 2022/09/07 06:00 [pubmed] PHST- 2022/09/09 06:00 [medline] AID - 01974520-202209000-00002 [pii] AID - 10.1097/HAP.0000000000000148 [doi] PST - ppublish SO - Front Health Serv Manage. 2022 Oct 1;39(1):4-10. doi: 10.1097/HAP.0000000000000148. PMID- 10885892 OWN - NLM STAT- MEDLINE DCOM- 20001114 LR - 20191210 IS - 1529-8663 (Print) IS - 1529-8663 (Linking) VI - 61 IP - 3 DP - 2000 May-Jun TI - Effect of temperature on the breakthrough of a charcoal tube during vinyl chloride monomer sampling. PG - 405-9 AB - This study evaluated the effects of temperature on breakthrough of two standard collection media at various concentrations during vinyl chloride monomer (VCM) sampling. The National Institute for Occupational Safety and Health (NIOSH) and Occupational Safety and Health Administration (OSHA) methods were evaluated. To determine whether breakthrough of VCM would occur at the extremes of exposure and temperature that might be encountered in some workplaces, air samples containing 4 ppm (10.24 mg/m3), 8 ppm (20.45 mg/m3), 16 ppm (40.98 mg/m3), and 32 ppm (81.80 mg/m3) of VCM were collected at temperatures of 4, 22, and 40 degrees C. Five liters of air was sampled at the rate of 0.05 L/min for 100 min using the activated charcoal tube recommended by NIOSH. A second tube was added to the sampling train to collect any VCM that might not have been absorbed in the first tube. To collect VCM air samples by the OSHA method, two carbon molecular sieve tubes were connected serially and 3 L of air was sampled at the rate of 0.05 L/min for 60 min. A gas chromatograph with a flame ionization detector and ultra 2 capillary column was used to analyze VCM. Significant breakthrough was found when sampling at higher temperatures with the NIOSH method. No breakthrough was found when samples were collected using the OSHA media at different temperatures and concentrations. Therefore, under hot ambient conditions (>22 degrees C), the possibility of breakthrough should be considered when sampling VCM by the NIOSH method. FAU - Roh, J AU - Roh J AD - Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Korea. FAU - Park, Y J AU - Park YJ FAU - Kim, C N AU - Kim CN FAU - Lim, N G AU - Lim NG FAU - Lee, S H AU - Lee SH FAU - Song, J S AU - Song JS FAU - Won, J U AU - Won JU FAU - Talaska, G AU - Talaska G LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - AIHAJ JT - AIHAJ : a journal for the science of occupational and environmental health and safety JID - 100939625 RN - 0 (Air Pollutants, Occupational) RN - 16291-96-6 (Charcoal) RN - WD06X94M2D (Vinyl Chloride) SB - IM MH - Air Pollutants, Occupational/*analysis MH - Analysis of Variance MH - Charcoal MH - Chromatography, Gas MH - Environmental Monitoring/*methods MH - National Institute for Occupational Safety and Health, U.S. MH - *Temperature MH - United States MH - United States Occupational Safety and Health Administration MH - Vinyl Chloride/*analysis EDAT- 2000/07/08 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/07/08 11:00 PHST- 2000/07/08 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/07/08 11:00 [entrez] AID - 10.1080/15298660008984551 [doi] PST - ppublish SO - AIHAJ. 2000 May-Jun;61(3):405-9. doi: 10.1080/15298660008984551. PMID- 38219539 OWN - NLM STAT- MEDLINE DCOM- 20240125 LR - 20240201 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 183 DP - 2024 Jan TI - The influence of humid heat on morbidity of megacity Shanghai in China. PG - 108424 LID - S0160-4120(24)00010-2 [pii] LID - 10.1016/j.envint.2024.108424 [doi] AB - BACKGROUND: Increased attention has been paid to humid-heat extremes as they are projected to increase in both frequency and intensity. However, it remains unclear how compound extremes of heat and humidity affects morbidity when the climate is projected to continue warming in the future, in particular for a megacity with a large population. METHODS: We chose the Wet-Bulb Globe Temperature (WBGT) index as the metric to characterize the humid-heat exposure. The historical associations between daily outpatient visits and daily mean WBGT was established using a Distributed Lag Non-linear Model (DLNM) during the warm season (June to September) from 2013 to 2015 in Shanghai, a prominent megacity of China. Future morbidity burden related to the combined effect of high temperature and humidity were projected under four greenhouse gases (GHGs) emission scenarios (SSP126, SSP245, SSP370 and SSP585). RESULTS: The humid-heat weather was significantly associated with a higher risk of outpatient visits in Shanghai than the high-temperature conditions. Relative to the baseline period (2010-2019), the morbidity burden due to humid-heat weather was projected to increase 4.4 % (95 % confidence interval (CI): 1.1 %-10.1 %) even under the strict emission control scenario (SSP126) by 2100. Under the high-GHGs emission scenario (SSP585), this burden was projected to be 25.4 % (95 % CI: 15.8 %-38.4 %), which is 10.1 % (95 % CI: 6.5 %-15.8 %) more than that due to high-temperature weather. Our results also indicate that humid-hot nights could cause large morbidity risks under high-GHGs emission scenarios particularly in heat-sensible diseases such as the respiratory and cardiovascular disease by the end of this century. CONCLUSIONS: Humid heat exposures significantly increased the all-cause morbidity risk in the megacity Shanghai, especially in humid-hot nights. Our findings suggest that the combined effect of elevated temperature and humidity is projected to have more substantial impact on health compared to high temperature alone in a warming climate. CI - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Liang, Chen AU - Liang C AD - Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences & CMA-FDU Joint Laboratory of Marine Meteorology, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, China. FAU - Yuan, Jiacan AU - Yuan J AD - Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences & CMA-FDU Joint Laboratory of Marine Meteorology, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, China. Electronic address: jcyuan@fudan.edu.cn. FAU - Tang, Xu AU - Tang X AD - Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences & CMA-FDU Joint Laboratory of Marine Meteorology, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, China. FAU - Kan, Haidong AU - Kan H AD - IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, China; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Cai, Wenjia AU - Cai W AD - Department of Earth System Science, Institute for Global Change Studies, Ministry of Education Ecological Field Station for East Asian Migratory Birds, Tsinghua University, Beijing 100084, China. FAU - Chen, Jianmin AU - Chen J AD - Department of Atmospheric and Oceanic Sciences & Institute of Atmospheric Sciences & CMA-FDU Joint Laboratory of Marine Meteorology, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, China. LA - eng PT - Journal Article DEP - 20240106 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Greenhouse Gases) SB - IM MH - *Hot Temperature MH - China MH - Temperature MH - *Greenhouse Gases MH - Humidity MH - Climate Change OTO - NOTNLM OT - Climate warming OT - Humid-heat OT - Megacity OT - Morbidity OT - WBGT COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/01/15 00:42 MHDA- 2024/01/25 06:43 CRDT- 2024/01/14 18:14 PHST- 2023/08/25 00:00 [received] PHST- 2023/12/12 00:00 [revised] PHST- 2024/01/03 00:00 [accepted] PHST- 2024/01/25 06:43 [medline] PHST- 2024/01/15 00:42 [pubmed] PHST- 2024/01/14 18:14 [entrez] AID - S0160-4120(24)00010-2 [pii] AID - 10.1016/j.envint.2024.108424 [doi] PST - ppublish SO - Environ Int. 2024 Jan;183:108424. doi: 10.1016/j.envint.2024.108424. Epub 2024 Jan 6. PMID- 37538989 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240617 IS - 1974-9791 (Print) IS - 2283-9216 (Electronic) IS - 1974-9791 (Linking) VI - 58 DP - 2017 Jun TI - Job Factors Associated with Occupational Injuries and Deaths in the United States Forestry Industry. PG - 115-120 LID - 10.3303/CET1758020 [doi] AB - Work in the forestry industry is recognised internationally as high risk for occupational injuries and deaths. Forestry logging operations generally involve felling trees, skidding (moving trees and logs from the stump to the point of delivery), and transporting trees to mills. Loggers need to recognize the hazards associated with identifying dangerous (dead) trees, felling, delimbing, bucking, debarking, chipping, skidding, yarding, loading, unloading, and transporting logs. The purpose of this study was to determine the specific work conditions and job factors that workers identified as greatest risk for injury or death in logging operations in the intermountain region of Montana and Idaho. The study investigators recruited professional loggers through logging companies and professional logging associations in the states of Idaho and Montana. The professional loggers were asked to participate in focus group meetings regarding their perception of the association between logging tasks and logging injuries / deaths. One focus group session of 16 participants for 90 minutes was conducted and moderated by the investigators. The focus group moderator posed a series of questions designed to promote group discussion regarding logging practices and injuries. Injury data from workers' compensation reports was also shared with the participants and served as a basis for the focus group questions. Felling trees was often associated with injuries sustained from falling branches. Conventional chainsaw logging and skyline skidding were perceived as high-risk processes. Loggers indicated that being struck by the carriage attached to the skyline was a significant risk. Other risks identified included being hit by the butt of swinging trees when that became snagged or caught on tree stumps as they were being skidded up the slope. Workers identified working on steep slopes as well as working in below freezing temperatures as a major risk for injury. Physical fatigue while performing strenuous work for 8-10 hours was also identified as a risk for injury. The results of this study identified work conditions (extreme cold temperatures, steep incline of mountain slope), as well as job factors (felling trees, skyline skidding, driving logging trucks) that professional loggers perceived as contributing to increased risk for occupational related injury and death. The conditions and factors identified will be used to target interventions that reduce the risk of logging injuries in the future. Due to the remote nature of the logging work in this region, emergency first-aid training among the crewmembers was thought to be a critical part of logging safety. A culture promoting safety was also stressed for professional loggers. FAU - Rosecrance, John AU - Rosecrance J AD - Colorado State University, Occupational Ergonomics and Safety Program, 1681 Campus Delivery, Fort Collins, Colorado, USA 80523. FAU - Lagerstrom, Elise AU - Lagerstrom E AD - Colorado State University, Occupational Ergonomics and Safety Program, 1681 Campus Delivery, Fort Collins, Colorado, USA 80523. FAU - Murgia, Lelia AU - Murgia L AD - University of Sassari, Dipartimento di AGRARIA, Viale Italia 39 - 07100 Sassari, Italy. LA - eng GR - T42 OH009229/OH/NIOSH CDC HHS/United States GR - T42OH009229/ACL/ACL HHS/United States GR - U54 OH008085/OH/NIOSH CDC HHS/United States PT - Journal Article PL - Italy TA - Chem Eng Trans JT - Chemical engineering transactions JID - 101701158 PMC - PMC10398574 MID - NIHMS1836115 EDAT- 2017/06/01 00:00 MHDA- 2017/06/01 00:01 PMCR- 2023/08/03 CRDT- 2023/08/04 04:08 PHST- 2017/06/01 00:01 [medline] PHST- 2017/06/01 00:00 [pubmed] PHST- 2023/08/04 04:08 [entrez] PHST- 2023/08/03 00:00 [pmc-release] AID - 10.3303/CET1758020 [doi] PST - ppublish SO - Chem Eng Trans. 2017 Jun;58:115-120. doi: 10.3303/CET1758020. PMID- 24582370 OWN - NLM STAT- MEDLINE DCOM- 20150518 LR - 20181202 IS - 1876-4754 (Electronic) IS - 1876-4754 (Linking) VI - 7 IP - 3 DP - 2014 May-Jun TI - A measure of acoustic noise generated from transcranial magnetic stimulation coils. PG - 432-4 LID - S1935-861X(14)00059-X [pii] LID - 10.1016/j.brs.2014.01.056 [doi] AB - The intensity of sound emanating from the discharge of magnetic coils used in repetitive transcranial magnetic stimulation (rTMS) can potentially cause acoustic trauma. Per Occupational Safety and Health Administration (OSHA) standards for safety of noise exposure, hearing protection is recommended beyond restricted levels of noise and time limits. We measured the sound pressure levels (SPLs) from four rTMS coils with the goal of assessing if the acoustic artifact levels are of sufficient amplitude to warrant protection from acoustic trauma per OSHA standards. We studied the SPLs at two frequencies (5 and 10 Hz), three machine outputs (MO) (60, 80 and 100%), and two distances from the coil (5 and 10 cm). We found that the SPLs were louder at closer proximity from the coil and directly dependent on the MO. We also found that in all studied conditions, SPLs were lower than the OSHA permissible thresholds for short (<15 min) acoustic exposure, but at extremes of use, may generate sufficient noise to warrant ear protection with prolonged (>8 h) exposure. CI - Copyright © 2014 Elsevier Inc. All rights reserved. FAU - Dhamne, Sameer C AU - Dhamne SC AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Kothare, Raveena S AU - Kothare RS AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Yu, Camilla AU - Yu C AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Hsieh, Tsung-Hsun AU - Hsieh TH AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Anastasio, Elana M AU - Anastasio EM AD - Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. FAU - Oberman, Lindsay AU - Oberman L AD - Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. FAU - Pascual-Leone, Alvaro AU - Pascual-Leone A AD - Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Institut Universitari de Neurorehabilitació Guttmann, Universidad Autónoma de Barcelona, Badalona, Spain. FAU - Rotenberg, Alexander AU - Rotenberg A AD - Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: alexander.rotenberg@childrens.harvard.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140129 PL - United States TA - Brain Stimul JT - Brain stimulation JID - 101465726 SB - IM CIN - Brain Stimul. 2015 Jan-Feb;8(1):161-3. doi: 10.1016/j.brs.2014.10.010. PMID: 25468074 MH - Acoustics MH - Equipment Design MH - Hearing Loss/prevention & control MH - Humans MH - Magnetics MH - *Noise MH - Occupational Exposure MH - Sound MH - Transcranial Magnetic Stimulation/*adverse effects MH - United States MH - United States Occupational Safety and Health Administration OTO - NOTNLM OT - Acoustic noise OT - Sound pressure levels OT - Transcranial magnetic stimulation EDAT- 2014/03/04 06:00 MHDA- 2015/05/20 06:00 CRDT- 2014/03/04 06:00 PHST- 2013/12/19 00:00 [received] PHST- 2014/01/22 00:00 [revised] PHST- 2014/01/24 00:00 [accepted] PHST- 2014/03/04 06:00 [entrez] PHST- 2014/03/04 06:00 [pubmed] PHST- 2015/05/20 06:00 [medline] AID - S1935-861X(14)00059-X [pii] AID - 10.1016/j.brs.2014.01.056 [doi] PST - ppublish SO - Brain Stimul. 2014 May-Jun;7(3):432-4. doi: 10.1016/j.brs.2014.01.056. Epub 2014 Jan 29. PMID- 39016315 OWN - NLM STAT- Publisher LR - 20240717 IS - 1365-2648 (Electronic) IS - 0309-2402 (Linking) DP - 2024 Jul 17 TI - Bracing for the next wave: A critical incident study of frontline decision-making, adaptation and learning in ambulance care during COVID-19. LID - 10.1111/jan.16340 [doi] AB - AIM: To explore frontline decision-making, adaptation, and learning in ambulance care during the evolving COVID-19 pandemic. DESIGN: Descriptive and interpretative qualitative study. METHODS: Twenty-eight registered nurses from the Swedish ambulance services described 56 critical incidents during the COVID-19 pandemic through free-text questionnaires. The material was analysed using the Critical Incident Technique and Interpretive Description through the lens of potential for resilient performance. RESULTS: The findings were synthesized into four themes: 'Navigating uncharted waters under never-ending pressure', 'Balancing on the brink of an abyss', 'Sacrificing the few to save the many' and 'Bracing for the next wave'. Frontline decision-making during a pandemic contribute to ethical dilemmas while necessitating difficult prioritizations to adapt and respond to limited resources. Learning was manifested through effective information sharing and the identification of successful adaptations as compared to maladaptations. CONCLUSIONS: During pandemics or under other extreme conditions, decisions must be made promptly, even amidst emerging chaos, potentially necessitating the use of untested methods and ad-hoc solutions due to initial lack of knowledge and guidelines. Within ambulance care, dynamic leadership becomes imperative, combining autonomous frontline decision-making with support from management. Strengthening ethical competence and fostering ethical discourse may enhance confidence in decision-making, particularly under ethically challenging circumstances. IMPACT: Performance under extreme conditions can elevate the risk of suboptimal decision-making and adverse outcomes, with older adults being especially vulnerable. Thus, requiring targeted decision support and interventions. Enhancing patient safety in ambulance care during such conditions demands active participation and governance from management, along with decision support and guidelines. Vertical communication and collaboration between management and frontline professionals are essential to ensure that critical information, guidelines, and resources are effectively disseminated and implemented. Further research is needed into management and leadership in ambulance care, alongside the ethical challenges in frontline decision-making under extreme conditions. REPORTING METHOD: Findings are reported per consolidated criteria for reporting qualitative research (COREQ). PATIENT OR PUBLIC CONTRIBUTION: No Patient or Public Contribution. CI - © 2024 The Author(s). Journal of Advanced Nursing published by John Wiley & Sons Ltd. FAU - Hedqvist, Ann-Therese AU - Hedqvist AT AUID- ORCID: 0000-0002-3103-9253 AD - Department of Health and Caring Sciences, Linnaeus University, Växjö, Sweden. AD - Ambulance Service, Region Kalmar, Västervik, Sweden. FAU - Holmberg, Mats AU - Holmberg M AUID- ORCID: 0000-0003-1878-0992 AD - Department of Health and Caring Sciences, Linnaeus University, Växjö, Sweden. AD - Department of Ambulance Service, Region Sörmland, Sweden. AD - Centre for Clinical Research, Uppsala University, Uppsala, Sweden. FAU - Bjurling-Sjöberg, Petronella AU - Bjurling-Sjöberg P AUID- ORCID: 0000-0003-0245-3057 AD - Centre for Clinical Research, Uppsala University, Uppsala, Sweden. AD - Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. AD - Department of Patient Safety, Region Sörmland, Sweden. FAU - Ekstedt, Mirjam AU - Ekstedt M AD - Department of Health and Caring Sciences, Linnaeus University, Växjö, Sweden. AD - Department of Learning, Informatics, Management and Ethics, LIME, Karolinska Institutet, Stockholm, Sweden. LA - eng GR - 20190249/Familjen Kamprads Stiftelse/ GR - DLL-940876/Centre of clinical research, Sörmland/ PT - Journal Article DEP - 20240717 PL - England TA - J Adv Nurs JT - Journal of advanced nursing JID - 7609811 SB - IM OTO - NOTNLM OT - COVID‐19 OT - ambulance care OT - critical incident technique OT - decision‐making OT - interpretive description OT - resilience EDAT- 2024/07/17 12:45 MHDA- 2024/07/17 12:45 CRDT- 2024/07/17 07:35 PHST- 2024/06/30 00:00 [revised] PHST- 2023/10/27 00:00 [received] PHST- 2024/07/05 00:00 [accepted] PHST- 2024/07/17 12:45 [medline] PHST- 2024/07/17 12:45 [pubmed] PHST- 2024/07/17 07:35 [entrez] AID - 10.1111/jan.16340 [doi] PST - aheadofprint SO - J Adv Nurs. 2024 Jul 17. doi: 10.1111/jan.16340. PMID- 22016569 OWN - NLM STAT- MEDLINE DCOM- 20120315 LR - 20200826 IS - 1465-2080 (Electronic) IS - 1350-0872 (Linking) VI - 157 IP - Pt 12 DP - 2011 Dec TI - Salmonella spp. survival strategies within the host gastrointestinal tract. PG - 3268-3281 LID - 10.1099/mic.0.050351-0 [doi] AB - Human salmonellosis infections are usually acquired via the food chain as a result of the ability of Salmonella serovars to colonize and persist within the gastrointestinal tract of their hosts. In addition, after food ingestion and in order to cause foodborne disease in humans, Salmonella must be able to resist several deleterious stress conditions which are part of the host defence against infections. This review gives an overview of the main defensive mechanisms involved in the Salmonella response to the extreme acid conditions of the stomach, and the elevated concentrations of bile salts, osmolytes and commensal bacterial metabolites, and the low oxygen tension conditions of the mammalian and avian gastrointestinal tracts. FAU - Álvarez-Ordóñez, Avelino AU - Álvarez-Ordóñez A AD - Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. AD - Department of Microbiology, University College Cork, Cork, Ireland. FAU - Begley, Máire AU - Begley M AD - Department of Microbiology, University College Cork, Cork, Ireland. FAU - Prieto, Miguel AU - Prieto M AD - Department of Food Hygiene and Technology, Veterinary Faculty, University of León, León, Spain. FAU - Messens, Winy AU - Messens W AD - Biological Hazards (BIOHAZ) Unit, European Food Safety Authority (EFSA), Largo N. Palli 5/A, I-43121 Parma, Italy. FAU - López, Mercedes AU - López M AD - Department of Food Hygiene and Technology, Veterinary Faculty, University of León, León, Spain. FAU - Bernardo, Ana AU - Bernardo A AD - Department of Food Hygiene and Technology, Veterinary Faculty, University of León, León, Spain. FAU - Hill, Colin AU - Hill C AD - Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. AD - Department of Microbiology, University College Cork, Cork, Ireland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20111020 PL - England TA - Microbiology (Reading) JT - Microbiology (Reading, England) JID - 9430468 RN - 0 (Acids) RN - 0 (Bile Acids and Salts) SB - IM MH - Acids/toxicity MH - Bile Acids and Salts/toxicity MH - Gastrointestinal Tract/*microbiology MH - Humans MH - *Microbial Viability MH - Salmonella/drug effects/*physiology MH - *Stress, Physiological EDAT- 2011/10/22 06:00 MHDA- 2012/03/16 06:00 CRDT- 2011/10/22 06:00 PHST- 2011/10/22 06:00 [entrez] PHST- 2011/10/22 06:00 [pubmed] PHST- 2012/03/16 06:00 [medline] AID - 10.1099/mic.0.050351-0 [doi] PST - ppublish SO - Microbiology (Reading). 2011 Dec;157(Pt 12):3268-3281. doi: 10.1099/mic.0.050351-0. Epub 2011 Oct 20. PMID- 36939484 OWN - NLM STAT- MEDLINE DCOM- 20230828 LR - 20231007 IS - 1097-6817 (Electronic) IS - 0194-5998 (Linking) VI - 169 IP - 3 DP - 2023 Sep TI - Experience With the New Active Transcutaneous Bone-Conduction Implant With Smaller Dimensions. PG - 615-621 LID - 10.1002/ohn.269 [doi] AB - OBJECTIVE: Recently, the Bonebridge 602 implant was introduced. Its smaller dimensions facilitate implantation even in surgically demanding cases. However, in extreme anatomical conditions, implant lifts are still required. We intended to report on the medical and audiological outcomes of all patients implanted with the implant with a secondary focus on the safety, efficacy, and feasibility of the use of 1-mm lifts. STUDY DESIGN: Retrospective cohort study. SETTING: Tertiary academic center. METHODS: We retrospectively analyzed all patients implanted with the Bonebridge 602. Patient demographics and surgically-specific data were collected from the medical charts. Furthermore, audiological results were assessed. Outcomes were compared between implantations with versus without lifts. RESULTS: Twenty-one devices were implanted during the study period. Satisfactory audiological results were observed, while no intra- or postoperative adverse events occurred. The majority of patients were daily users at the end of the observation period (n = 20/21, 95.2%), and one patient (n = 1/21, 4.8%) was a nonuser after 6 months of use because of subjective dissatisfaction. Due to anatomical considerations, 1-mm lifts were used in 4 implantations (19.0%). The application of lifts did not result in prolonged surgical times, complications, or shorter time of use, nor did it negatively affect audiometric results. CONCLUSION: Implantations with the new and smaller Bonebridge were associated with gratifying medical and audiological outcomes. Still, in extreme anatomical conditions, 1-mm lifts are necessary. Nonetheless, surgical placement with the help of lifts seems safe, effective, and feasible, and is a viable option in cases with challenging anatomies due to previous surgeries or anomalies. CI - © 2023 The Authors. Otolaryngology-Head and Neck Surgery published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology-Head and Neck Surgery Foundation. FAU - Brkic, Faris F AU - Brkic FF AUID- ORCID: 0000-0002-0770-6677 AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Baumgartner, Wolf-Dieter AU - Baumgartner WD AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Schlott, Melina AU - Schlott M AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Liu, David T AU - Liu DT AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Thurner, Thomas AU - Thurner T AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Riss, Dominik AU - Riss D AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Gstöttner, Wolfgang AU - Gstöttner W AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. FAU - Vyskocil, Erich AU - Vyskocil E AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. LA - eng PT - Journal Article DEP - 20230129 PL - England TA - Otolaryngol Head Neck Surg JT - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JID - 8508176 SB - IM MH - Humans MH - Retrospective Studies MH - *Prostheses and Implants/adverse effects MH - Bone Conduction MH - Prosthesis Implantation/methods MH - Audiometry MH - *Hearing Aids/adverse effects MH - Hearing Loss, Conductive/surgery MH - Treatment Outcome OTO - NOTNLM OT - Bonebridge 602 OT - efficacy OT - implant lifts OT - safety EDAT- 2023/03/21 06:00 MHDA- 2023/08/28 06:42 CRDT- 2023/03/20 10:33 PHST- 2022/12/13 00:00 [revised] PHST- 2022/11/07 00:00 [received] PHST- 2022/12/29 00:00 [accepted] PHST- 2023/08/28 06:42 [medline] PHST- 2023/03/21 06:00 [pubmed] PHST- 2023/03/20 10:33 [entrez] AID - 10.1002/ohn.269 [doi] PST - ppublish SO - Otolaryngol Head Neck Surg. 2023 Sep;169(3):615-621. doi: 10.1002/ohn.269. Epub 2023 Jan 29. PMID- 34129213 OWN - NLM STAT- MEDLINE DCOM- 20211026 LR - 20211026 IS - 1920-7476 (Electronic) IS - 0008-4263 (Print) IS - 0008-4263 (Linking) VI - 112 IP - 4 DP - 2021 Aug TI - Reimagining spaces where children play: developing guidance for thermally comfortable playgrounds in Canada. PG - 706-713 LID - 10.17269/s41997-021-00522-7 [doi] AB - SETTING: Planning and designing thermally comfortable outdoor spaces is increasingly important in the context of climate change, particularly as children are more vulnerable than adults to environmental extremes. However, existing playground standards focus on equipment and surfacing to reduce acute injuries, with no mention of potential negative health consequences related to heat illness, sun exposure, and other thermal extremes. The goal of this project was to develop proposed guidelines for designing thermally comfortable playgrounds in Canada for inclusion within the CAN/CSA-Z614 Children's playground equipment and surfacing standard. INTERVENTION: The project to develop guidance for thermally comfortable playgrounds was initiated with a municipal project in Windsor, Ontario, to increase shade, vegetation, and water features at parks and playgrounds to provide more comfortable experiences amid the increased frequency of hot days (≥30°C). The lack of available information to best manage environmental conditions led to a collaborative effort to build resources and raise awareness of best practices in the design of thermally comfortable playgrounds. OUTCOMES: A group of multidisciplinary experts developed technical guidance for improving thermal comfort at playgrounds, including a six-page thermal comfort annex adopted within a national playground and equipment standard. The annex has been used by Canadian schools in a competition to design and implement green playgrounds. IMPLICATIONS: Both the technical report and the thermal comfort annex provide increased awareness and needed guidance for managing environmental conditions at playgrounds. Thermally safe and comfortable play spaces will help ensure that Canada's playgrounds are designed to minimize environmental health risks for children. FAU - Kennedy, Eric AU - Kennedy E AD - National Program for Playground Safety, Cedar Falls, IA, USA. AD - Biomedical Engineering Department, Bucknell University, Lewisburg, PA, USA. FAU - Olsen, Heather AU - Olsen H AD - National Program for Playground Safety, Cedar Falls, IA, USA. AD - Department of Health, Recreation, and Community Services, University of Northern Iowa, Cedar Falls, IA, USA. FAU - Vanos, Jennifer AU - Vanos J AD - School of Sustainability, Arizona State University, Tempe, AZ, USA. FAU - Vecellio, Daniel J AU - Vecellio DJ AD - Department of Geography, Texas A&M University, College Station, TX, USA. FAU - Desat, Marla AU - Desat M AD - Strategy and Stakeholder Engagement Branch, Standards Council of Canada, Ottawa, ON, Canada. FAU - Richters, Karina AU - Richters K AD - Environmental Sustainability and Climate Change, City of Windsor, Windsor, ON, Canada. FAU - Rutledge, Alexandra AU - Rutledge A AD - Climate Change and Innovation Bureau, Health Canada, Ottawa, ON, Canada. FAU - Richardson, Gregory R A AU - Richardson GRA AD - Climate Change and Innovation Bureau, Health Canada, Ottawa, ON, Canada. gregory.richardson@canada.ca. LA - eng GR - Standards to Support Resilience in Infrastructure Program/Standards Council of Canada/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210615 PL - Switzerland TA - Can J Public Health JT - Canadian journal of public health = Revue canadienne de sante publique JID - 0372714 SB - IM MH - *Built Environment/standards MH - Canada MH - Child MH - Guidelines as Topic MH - Humans MH - *Play and Playthings/injuries MH - *Temperature PMC - PMC8225778 OTO - NOTNLM OT - Child OT - Environment OT - Environment and public health OT - Microclimate OT - Playground OT - Recreation COIS- The authors declare that they have no conflicts of interest. EDAT- 2021/06/16 06:00 MHDA- 2021/10/27 06:00 PMCR- 2021/06/15 CRDT- 2021/06/15 13:42 PHST- 2020/04/01 00:00 [received] PHST- 2021/03/29 00:00 [accepted] PHST- 2021/06/16 06:00 [pubmed] PHST- 2021/10/27 06:00 [medline] PHST- 2021/06/15 13:42 [entrez] PHST- 2021/06/15 00:00 [pmc-release] AID - 10.17269/s41997-021-00522-7 [pii] AID - 522 [pii] AID - 10.17269/s41997-021-00522-7 [doi] PST - ppublish SO - Can J Public Health. 2021 Aug;112(4):706-713. doi: 10.17269/s41997-021-00522-7. Epub 2021 Jun 15. PMID- 10723879 OWN - NLM STAT- MEDLINE DCOM- 20000327 LR - 20190831 IS - 0140-0118 (Print) IS - 0140-0118 (Linking) VI - 37 IP - 6 DP - 1999 Nov TI - Experimental analysis of the human perception threshold of a DC electric field. PG - 727-32 AB - To study the biological effects of extremely low frequency (ELF) electric fields, a fundamental study is conducted of the human perception threshold of an electric field. The perception threshold is measured with human subjects, and the results are analysed. It is clear that field perception is based on the movement of hair and not on other sensations. Variance in the perception threshold and its causes are investigated. The perception threshold decreases by almost 30% as the relative humidity increases from 50 to 90%. The perception threshold is also dependent on the physical condition (length and density) of the hair and the psychological condition (degree of awareness) of the subject. The dependence on these is much smaller than that on relative humidity. The cause of the gender difference in the threshold is ascribed to the difference in the physical condition of the hair. Through this study, some factors to be taken into account for the safety standard are made clear. FAU - Odagiri-Shimizu, H AU - Odagiri-Shimizu H AD - Hokkaido Institute of Technology, Sapporo, Japan. shimizu@hit.ac.jp FAU - Shimizu, K AU - Shimizu K LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Med Biol Eng Comput JT - Medical & biological engineering & computing JID - 7704869 SB - IM MH - Adult MH - Awareness/physiology MH - *Electromagnetic Fields MH - Female MH - Hair/physiology MH - Humans MH - Male MH - Movement/physiology MH - *Sensory Thresholds MH - Static Electricity EDAT- 2000/03/21 09:00 MHDA- 2000/04/01 09:00 CRDT- 2000/03/21 09:00 PHST- 2000/03/21 09:00 [pubmed] PHST- 2000/04/01 09:00 [medline] PHST- 2000/03/21 09:00 [entrez] AID - 10.1007/BF02513374 [doi] PST - ppublish SO - Med Biol Eng Comput. 1999 Nov;37(6):727-32. doi: 10.1007/BF02513374. PMID- 34391187 OWN - NLM STAT- MEDLINE DCOM- 20210914 LR - 20211005 IS - 1873-2976 (Electronic) IS - 0960-8524 (Linking) VI - 340 DP - 2021 Nov TI - Heterologous expression of bacterial CotA-laccase, characterization and its application for biodegradation of malachite green. PG - 125708 LID - S0960-8524(21)01049-X [pii] LID - 10.1016/j.biortech.2021.125708 [doi] AB - Malachite green (MG) is used as fungicide/parasiticide in aquaculture, its persistence is detrimental as it exhibits carcinogenic effects to aquatic organisms. Bacterial laccase evaluated as the best enzyme at extreme condition for aquatic MG removal. Study aims to increase laccase concentration, CotA-laccase from Bacillus subtilis was cloned and overexpressed in Escherichia coli. Optimal catalysis for purified CotA-laccase were at pH 5.0, 60 °C, and 1 mM of (2,2-azino-di-[3-ethylbenzothiazoline-sulphonate-(6)]) with Km and Kcat 0.087 mM and 37.64 S(-1) respectively. MG biodegradation by CotA-laccase in clam and tilapia pond wastewaters and cytotoxic effect of biodegraded products in grouper fin-1 cells were determined. MG degradation by CotA-laccase was equally efficient, exhibiting upto 90-94% decolorization at freshwater and saline conditions and treated solution was non-toxic to GF-1 cells. Thus, recombinant-CotA-laccase could be an environmentally-friendly enzyme for aquaculture to remove MG, thereby effective to reduce its accumulation in aquatic organisms and ensuring safe aquaculture products. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Cheng, Chiu-Min AU - Cheng CM AD - Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Taiwan. FAU - Patel, Anil Kumar AU - Patel AK AD - Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan. FAU - Singhania, Reeta Rani AU - Singhania RR AD - Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan. FAU - Tsai, Cheng-Hsian AU - Tsai CH AD - Department of Chemical and Materials Engineering, National Kaohsiung University of Science and Technology, Taiwan. FAU - Chen, Shen-Yi AU - Chen SY AD - Department of Safety, Health, and Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan. FAU - Chen, Chiu-Wen AU - Chen CW AD - Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan. FAU - Dong, Cheng Di AU - Dong CD AD - Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Taiwan. Electronic address: cddong@nkust.edu.tw. LA - eng PT - Journal Article DEP - 20210803 PL - England TA - Bioresour Technol JT - Bioresource technology JID - 9889523 RN - 0 (Bacterial Proteins) RN - 0 (Coloring Agents) RN - 0 (Rosaniline Dyes) RN - 12058M7ORO (malachite green) RN - EC 1.10.3.2 (Laccase) SB - IM EIN - Bioresour Technol. 2021 Dec;341:125792. doi: 10.1016/j.biortech.2021.125792. PMID: 34419882 MH - Bacillus subtilis MH - Bacterial Proteins MH - Coloring Agents MH - Escherichia coli/genetics MH - Hydrogen-Ion Concentration MH - *Laccase/genetics MH - *Rosaniline Dyes/toxicity OTO - NOTNLM OT - ABTS OT - CotA-laccase OT - Malachite green OT - Overexpression OT - Recombinant-CotA EDAT- 2021/08/15 06:00 MHDA- 2021/09/15 06:00 CRDT- 2021/08/14 20:28 PHST- 2021/07/08 00:00 [received] PHST- 2021/07/28 00:00 [revised] PHST- 2021/07/29 00:00 [accepted] PHST- 2021/08/15 06:00 [pubmed] PHST- 2021/09/15 06:00 [medline] PHST- 2021/08/14 20:28 [entrez] AID - S0960-8524(21)01049-X [pii] AID - 10.1016/j.biortech.2021.125708 [doi] PST - ppublish SO - Bioresour Technol. 2021 Nov;340:125708. doi: 10.1016/j.biortech.2021.125708. Epub 2021 Aug 3. PMID- 1298192 OWN - NLM STAT- MEDLINE DCOM- 19930503 LR - 20091111 IS - 0003-3928 (Print) IS - 0003-3928 (Linking) VI - 41 IP - 9 DP - 1992 Nov TI - [Preventive drug therapy of recurrence of atrial fibrillation]. PG - 497-507 AB - Without treatment, about 60% of atrial arrhythmia patients suffer a relapse within 3 months and 70% within one year. Antiarrhythmic treatment intended to reduce this percentage is therefore justified, on condition that it is well tolerated. Several preliminary questions have to be settled before this medical prophylaxis: 1) Justification of antiarrhythmic treatment (sometimes pointless to deal with very occasional episodes); 2) Treatment of the underlying heart disease (valve disease, cardiothyrotoxicosis, etc.) or promoting factors (potassium depletion etc.); 3) Accurate assessment of any associated conduction abnormalities, which may constitute a contraindication to antiarrhythmic treatment (WPW syndrome in the case of verapamil and the digitalis-like drugs) or require additional treatment (pacemaker); 4) Definition of the mechanism (vagal or sympathotonic) inducing arrhythmia; 5) Evaluation of the hemodynamic parameters of the underlying heart disease (size of the atria, ventricular function, coronary or valvular lesions) which may limit the efficacy of the treatment. Once these parameters have been identified, the primary treatment should be type la or lb antiarrhythmics, which have been shown to be effective, despite the fact that they are not without arrhythmic risks (the Ib antiarrhythmics are less effective and have a poor safety profile). The beta-blockers have preferential indications (hypersympatheticotonia, hyperthyroidism, hypertrophic myocardiopathy, mitral prolapse, angina etc.) and can be replaced by verapamil or bepridil if there are non-cardiac contraindications (ulcers, asthma, diabetes). Amiodarone is extremely effective, but its poor extracardiac safety restricts its long-term use. Complementary treatments (digitalis-like, anticoagulants or anti-PAF and cardiostimulant drugs) should be added if necessary. Recurrences (to be confirmed by ECG or Holter) should lead to rigorous confirmation of therapeutic compliance and observance of simple hygienic and dietary measures (no excessive exertion, elimination of stimulants etc.). With strict clinical and ECG monitoring, it would then be possible either to increase the dose levels (accompanied by plasma determinations if possible) or to switch to a treatment with more effective, but more aggressive drugs (amiodarone, flecainide) or to use drug associations (la and lb, la and II etc.). Repeated failure of such attempts should lead to a non-medical approach to treatment. FAU - Fauchier, J P AU - Fauchier JP AD - Service de Cardiologie B, Hôpital Trousseau, Tours. FAU - Babuty, D AU - Babuty D FAU - Fauchier, L AU - Fauchier L FAU - Cosnay, P AU - Cosnay P FAU - Breuillac, J C AU - Breuillac JC FAU - Rouesnel, P AU - Rouesnel P LA - fre PT - English Abstract PT - Journal Article PT - Review TT - Prévention médicamenteuse des récidives de fibrillation auriculaire. PL - France TA - Ann Cardiol Angeiol (Paris) JT - Annales de cardiologie et d'angeiologie JID - 0142167 RN - 0 (Anti-Arrhythmia Agents) SB - IM MH - Anti-Arrhythmia Agents/classification/*therapeutic use MH - Atrial Fibrillation/drug therapy/physiopathology/*prevention & control MH - Drug Therapy, Combination MH - Humans MH - Recurrence RF - 72 EDAT- 1992/11/01 00:00 MHDA- 1992/11/01 00:01 CRDT- 1992/11/01 00:00 PHST- 1992/11/01 00:00 [pubmed] PHST- 1992/11/01 00:01 [medline] PHST- 1992/11/01 00:00 [entrez] PST - ppublish SO - Ann Cardiol Angeiol (Paris). 1992 Nov;41(9):497-507. PMID- 12035695 OWN - NLM STAT- MEDLINE DCOM- 20020627 LR - 20241219 IS - 0278-4807 (Print) IS - 0278-4807 (Linking) VI - 26 IP - 3 DP - 2001 May-Jun TI - Family caregiver expectations and management of the stroke trajectory. PG - 94-9 AB - Less than 20% of stroke survivors enter rehabilitation or long-term care facilities after their stroke. Stroke recovery is extremely variable and the resulting uncertainty places a heavy burden on the survivors' family caregivers. According to the trajectory framework, chronic conditions have a defined course that can be shaped and managed. This grounded theory study, part of a larger research project, explored the expectations of family caregivers of the stroke trajectory and their management strategies. Thirteen family caregivers of stroke patients in a sparsely populated area participated in semi-structured interviews. The caregivers were without ideas about what the recovery of their loved ones would be like and had difficulty making projections about the trajectory. They used several strategies, however, in attempts to manage the stroke trajectory. They constructed a positive recovery, reconstituted family life, maintained family routines, created a safety net, and redoubled self-reliance. The findings have implications for how nurses support family caregivers of stroke survivors. FAU - Burman, M E AU - Burman ME AD - School of Nursing, University of Wyoming, PO Box 3065, Laramie, WY 82071-3065, USA. mburman@uwyo.edu LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Rehabil Nurs JT - Rehabilitation nursing : the official journal of the Association of Rehabilitation Nurses JID - 8104825 MH - *Attitude to Health MH - Caregivers/*psychology MH - Chronic Disease MH - Cost of Illness MH - Family Health MH - Humans MH - Nursing Services/*standards MH - *Stroke Rehabilitation EDAT- 2002/05/31 10:00 MHDA- 2002/06/28 10:01 CRDT- 2002/05/31 10:00 PHST- 2002/05/31 10:00 [pubmed] PHST- 2002/06/28 10:01 [medline] PHST- 2002/05/31 10:00 [entrez] AID - 10.1002/j.2048-7940.2001.tb02212.x [doi] PST - ppublish SO - Rehabil Nurs. 2001 May-Jun;26(3):94-9. doi: 10.1002/j.2048-7940.2001.tb02212.x. PMID- 30235814 OWN - NLM STAT- MEDLINE DCOM- 20190131 LR - 20190131 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 15 IP - 9 DP - 2018 Sep 19 TI - Establishing Heat Alert Thresholds for the Varied Climatic Regions of British Columbia, Canada. LID - 10.3390/ijerph15092048 [doi] LID - 2048 AB - Following an extreme heat event in 2009, a Heat Alert and Response System (HARS) was implemented for the greater Vancouver area of British Columbia (BC), Canada. This system has provided a framework for guiding public health interventions and assessing population response and adaptation to extreme heat in greater Vancouver, but no other parts of BC were covered by HARS. The objective of this study was to identify evidence-based heat alert thresholds for the Southwest, Southeast, Northwest, and Northeast regions to facilitate the introduction of HARS across BC. This was done based on a national approach that considers high temperatures on two consecutive days and the intervening overnight low, referred to as the high-low-high approach. Daily forecast and observed air temperatures and daily mortality counts for May through September of 2004 through 2016 were obtained. For each date (day(t)), day(t-2) forecasts were used to assign high temperatures for day(t) and day(t+1) and the overnight low. A range of high-low-high threshold combinations was assessed for each region by finding associations with daily mortality using time-series models and other considerations. The following thresholds were established: 29-16-29 °C in the Southwest; 35-18-35 °C in the Southeast; 28-13-28 °C in the Northwest; and 29-14-29 °C in the Northeast. Heat alert thresholds for all regions in BC provide health authorities with information on dangerously hot temperature conditions and inform the activation of protective public health interventions. FAU - McLean, Kathleen E AU - McLean KE AD - British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada. kathleen.mclean@bccdc.ca. FAU - Stranberg, Rebecca AU - Stranberg R AD - Climate Change and Innovation Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue West, Ottawa, ON K1A 0K9, Canada. rebecca.stranberg@canada.ca. FAU - MacDonald, Melissa AU - MacDonald M AD - National Health and Air Quality Program, Meteorological Service of Canada, Environment and Climate Change Canada, 45 Alderney Dr, Dartmouth, NS B2Y 2N6, Canada. melissa.macdonald@canada.ca. FAU - Richardson, Gregory R A AU - Richardson GRA AD - Climate Change and Innovation Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue West, Ottawa, ON K1A 0K9, Canada. gregory.richardson@canada.ca. FAU - Kosatsky, Tom AU - Kosatsky T AD - British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada. tom.kosatsky@bccdc.ca. FAU - Henderson, Sarah B AU - Henderson SB AUID- ORCID: 0000-0002-3329-184X AD - British Columbia Centre for Disease Control, 655 West 12th Ave, Vancouver, BC V5Z 4R4, Canada. sarah.henderson@bccdc.ca. LA - eng GR - MOA#4500368407/Health Canada/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180919 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - British Columbia MH - *Extreme Heat MH - Forecasting MH - Hot Temperature MH - Humans MH - *Mortality MH - Public Health MH - Public Service Announcements as Topic/*standards MH - Temperature PMC - PMC6163932 OTO - NOTNLM OT - climate change OT - early warning systems OT - extreme heat OT - heat alert and response system OT - mortality OT - public health surveillance OT - temperature COIS- The authors declare no conflict of interest. EDAT- 2018/09/22 06:00 MHDA- 2019/02/01 06:00 PMCR- 2018/09/01 CRDT- 2018/09/22 06:00 PHST- 2018/07/31 00:00 [received] PHST- 2018/09/14 00:00 [revised] PHST- 2018/09/18 00:00 [accepted] PHST- 2018/09/22 06:00 [entrez] PHST- 2018/09/22 06:00 [pubmed] PHST- 2019/02/01 06:00 [medline] PHST- 2018/09/01 00:00 [pmc-release] AID - ijerph15092048 [pii] AID - ijerph-15-02048 [pii] AID - 10.3390/ijerph15092048 [doi] PST - epublish SO - Int J Environ Res Public Health. 2018 Sep 19;15(9):2048. doi: 10.3390/ijerph15092048. PMID- 35199974 OWN - NLM STAT- MEDLINE DCOM- 20220620 LR - 20220622 IS - 1827-1596 (Electronic) IS - 0375-9393 (Linking) VI - 88 IP - 6 DP - 2022 Jun TI - What's new on the management of obstetric patients who tested positive for COVID-19? PG - 516-523 LID - 10.23736/S0375-9393.22.16283-8 [doi] AB - To date, there is still partial data on the effects of COVID-19 on pregnant women. The constant collection of information results in a continuous updating of the knowledge about the best management of pregnant patients affected by COVID-19. This work aimed to summarize the state of the art on prevention and management of SARS-CoV-2 infection in obstetric patients. This was enabled by a comprehensive literature search for the most recent and relevant publications on the subject, including guidelines and recommendations. Management of these women by a multidisciplinary team is of crucial importance, given the extreme clinical complexity of this condition. Every health worker involved must put in place all possible procedures to protect themselves from contagion. Neuraxial anesthesia should be favored in the management of labor and caesarean section over other modalities, unless there are contraindications based on the patient's status. There is still no standardized drug treatment in pregnant women with COVID-19 due to their exclusion from studies conducted to evaluate pharmacological therapies. Nevertheless, various drugs have been used to treat this disease in pregnancy, although the data at our disposal are still few. As regards mRNA vaccines, it seems that their immunogenicity, safety and tolerability in pregnant women are comparable to those of non-pregnant women of the same age. More studies are certainly needed in infected pregnant women to establish treatment and prevention protocols for this special category of patients. FAU - Giorgini, Carla AU - Giorgini C AD - Division of Anesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. FAU - Simonte, Rachele AU - Simonte R AD - Division of Anesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. FAU - Cammarota, Gianmaria AU - Cammarota G AD - Division of Anesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy. FAU - DE Robertis, Edoardo AU - DE Robertis E AD - Division of Anesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery, S. Maria della Misericordia Hospital, University of Perugia, Perugia, Italy - edoardo.derobertis@unipg.it. LA - eng PT - Journal Article DEP - 20220224 PL - Italy TA - Minerva Anestesiol JT - Minerva anestesiologica JID - 0375272 SB - IM MH - *COVID-19 MH - Cesarean Section MH - Female MH - Humans MH - Pregnancy MH - *Pregnancy Complications, Infectious/diagnosis/therapy MH - SARS-CoV-2 EDAT- 2022/02/25 06:00 MHDA- 2022/06/22 06:00 CRDT- 2022/02/24 11:46 PHST- 2022/02/25 06:00 [pubmed] PHST- 2022/06/22 06:00 [medline] PHST- 2022/02/24 11:46 [entrez] AID - S0375-9393.22.16283-8 [pii] AID - 10.23736/S0375-9393.22.16283-8 [doi] PST - ppublish SO - Minerva Anestesiol. 2022 Jun;88(6):516-523. doi: 10.23736/S0375-9393.22.16283-8. Epub 2022 Feb 24. PMID- 28697315 OWN - NLM STAT- MEDLINE DCOM- 20170904 LR - 20170904 IS - 1744-764X (Electronic) IS - 1474-0338 (Linking) VI - 16 IP - 9 DP - 2017 Sep TI - An update on anesthetics and impact on the brain. PG - 997-1008 LID - 10.1080/14740338.2017.1351539 [doi] AB - While anesthetics are indispensable clinical tools and generally considered safe and effective, a growing concern over the potential neurotoxicity of anesthesia or specific anesthetic agents has called into question the safety of general anesthetics, especially when administered at extremes of age. Areas covered: This article reviews and updates research findings on the safety of anesthesia and anesthetics in terms of long-term neurotoxicity, with particular focus on postoperative cognitive dysfunctions, Alzheimer's disease and dementias, developing brain, post-operative depression and autism spectrum disorder. Expert opinion: Exposure to general anesthetics is potentially harmful to the human brain, and the consequent long-term cognitive deficits should be classified as an iatrogenic pathology, and considered a public health problem. The fact that in laboratory and clinical research only certain anesthetic agents and techniques, but not others, appear to be involved, raises the problem on what is the safest and the least safe anesthetic to maximize anesthesia efficiency, avoid occurrence of adverse events, and ensure patient safety. New trends in research are moving toward the theory that neuroinflammation could be the hallmark of, or could have a pivotal role in, several neurological disorders. FAU - Fodale, Vincenzo AU - Fodale V AD - a Department of Human Pathology of Adult and Evolutive Age , Section of Anesthesiology, University of Messina , Messina , Italy. FAU - Tripodi, Vincenzo F AU - Tripodi VF AD - b Department of Cardiac Surgery, Unit of Cardioanesthesia , Metropolitan Hospital "Bianchi Melacrino Morelli" , Reggio Calabria , Italy. FAU - Penna, Olivia AU - Penna O AD - a Department of Human Pathology of Adult and Evolutive Age , Section of Anesthesiology, University of Messina , Messina , Italy. FAU - Famà, Fausto AU - Famà F AD - a Department of Human Pathology of Adult and Evolutive Age , Section of Anesthesiology, University of Messina , Messina , Italy. FAU - Squadrito, Francesco AU - Squadrito F AD - c Department of Clinical and Experimental Medicine , University of Messina , Messina , Italy. FAU - Mondello, Epifanio AU - Mondello E AD - a Department of Human Pathology of Adult and Evolutive Age , Section of Anesthesiology, University of Messina , Messina , Italy. FAU - David, Antonio AU - David A AD - a Department of Human Pathology of Adult and Evolutive Age , Section of Anesthesiology, University of Messina , Messina , Italy. LA - eng PT - Journal Article PT - Review DEP - 20170718 PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - 0 (Anesthetics) RN - 0 (Anesthetics, General) SB - IM MH - Age Factors MH - Anesthesia, General/adverse effects/methods MH - Anesthetics/administration & dosage/adverse effects MH - Anesthetics, General/administration & dosage/*adverse effects MH - Animals MH - Brain/*drug effects/pathology MH - Cognition Disorders/chemically induced/physiopathology MH - Humans MH - Neurotoxicity Syndromes/*etiology/physiopathology MH - Time Factors OTO - NOTNLM OT - Alzheimer’s disease OT - anesthesia OT - autism spectrum disorder OT - developing brain OT - neuroinflammation OT - neurotoxicity OT - postoperative cognitive dysfunctions OT - safety EDAT- 2017/07/12 06:00 MHDA- 2017/09/05 06:00 CRDT- 2017/07/12 06:00 PHST- 2017/07/12 06:00 [pubmed] PHST- 2017/09/05 06:00 [medline] PHST- 2017/07/12 06:00 [entrez] AID - 10.1080/14740338.2017.1351539 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2017 Sep;16(9):997-1008. doi: 10.1080/14740338.2017.1351539. Epub 2017 Jul 18. PMID- 33218391 OWN - NLM STAT- MEDLINE DCOM- 20201130 LR - 20230302 IS - 1875-6263 (Electronic) IS - 1028-4559 (Print) IS - 1028-4559 (Linking) VI - 59 IP - 6 DP - 2020 Nov TI - COVID-19 pandemic's effects on the quality of pregnant women's emergency treatment: Review of two cases from a medical center in northern Taiwan. PG - 795-800 LID - S1028-4559(20)30214-X [pii] LID - 10.1016/j.tjog.2020.09.003 [doi] AB - The spread of COVID-19 has resulted in a high risk of infection in hospitals worldwide. The medical staff in emergency rooms, in particular, have borne the brunt of the pandemic, and strict protection measures are needed to avoid infection in these units. Taiwan as a whole has performed extremely well in this epidemic, an achievement that has been acknowledged internationally. This success can be attributed to the Taiwan Epidemic Prevention Management Center's extensive experience and courageous strategy. The emergency department professionals of all hospitals, in conjunction with the outstanding performance of the center's policy, have also done much to control the infection's spread. However, excessive protection can also negatively affect patients' safety and the quality of medical care, especially for pregnant and parturient women. This article uses two actual cases from a medical center in northern Taiwan to discuss the impact of COVID-19 on pregnant women. This case study serves to highlight that, to ensure more effective coordination during severe epidemics, a comprehensive infection prevention plan should be formulated. In addition, pregnant women's human rights must be safeguarded so that various protective mechanisms can be effectively used to achieve win-win solutions. Hospitals need to plan their production methods and timing in advance for when pregnant patients are in critical condition. The findings include that obstetricians recommend caesarean sections as a safer method in during epidemics. Emergency room physicians and obstetricians should also actively assist mothers prepare for birth to enhance maternal and fetal safety. CI - Copyright © 2020. Published by Elsevier B.V. FAU - Chang, Wen-Han AU - Chang WH AD - Department of Medicine, Mackay Medical College, New Taipei, Taiwan; Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; Institute of Mechatronic Engineering, National Taipei University of Technology, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: branden888@gmail.com. LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20200910 PL - China (Republic : 1949- ) TA - Taiwan J Obstet Gynecol JT - Taiwanese journal of obstetrics & gynecology JID - 101213819 SB - IM MH - Adult MH - Betacoronavirus MH - COVID-19 MH - Cesarean Section/standards MH - Coronavirus Infections/*prevention & control MH - Cross Infection/*prevention & control/virology MH - Disease Transmission, Infectious/prevention & control MH - Emergency Service, Hospital/*standards MH - Female MH - Humans MH - Obstetrics/standards MH - Pandemics/*prevention & control MH - Perinatal Care/*standards MH - Pneumonia, Viral/*prevention & control MH - Pregnancy MH - Pregnancy Complications, Infectious/*prevention & control/virology MH - SARS-CoV-2 MH - Taiwan/epidemiology PMC - PMC7832363 OTO - NOTNLM OT - COVID-19 OT - Emergency department OT - Fetal safety OT - Pregnant COIS- Declaration of competing interest The authors have no conflicts of interest relevant to this article. EDAT- 2020/11/22 06:00 MHDA- 2020/12/01 06:00 PMCR- 2020/09/10 CRDT- 2020/11/21 05:24 PHST- 2020/07/28 00:00 [accepted] PHST- 2020/11/21 05:24 [entrez] PHST- 2020/11/22 06:00 [pubmed] PHST- 2020/12/01 06:00 [medline] PHST- 2020/09/10 00:00 [pmc-release] AID - S1028-4559(20)30214-X [pii] AID - 10.1016/j.tjog.2020.09.003 [doi] PST - ppublish SO - Taiwan J Obstet Gynecol. 2020 Nov;59(6):795-800. doi: 10.1016/j.tjog.2020.09.003. Epub 2020 Sep 10. PMID- 36984167 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230331 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 16 IP - 6 DP - 2023 Mar 13 TI - Influences of Flood Conditions on Dynamic Characteristics of Novel 3D-Printed Porous Bridge Bearings. LID - 10.3390/ma16062288 [doi] LID - 2288 AB - As the key safety-critical component of a bridge support system, bridge bearings are extensively used to accommodate, balance, and transfer differential displacements and loads between the superstructure and substructure of a bridge during operations. Several studies have been conducted to obtain dynamic modal parameters of traditional bridge bearings only in perfectly dry environments. However, in extreme weather conditions (e.g., heavy rain, flash floods, etc.), water can ingress and change the bearings' properties. In this study, novel 3D-printed porous bridge bearings (3DPPBBs) have been fabricated by Fused Deposition Modeling (FDM) with thermoplastic polyurethane (TPU) filaments. This study is the first to determine the influences of flood conditions on their dynamic properties, which has never been done before. An idealised single degree of freedom (ISDOF) for these novel bearings is considered for the non-destructive field-testing technique of the critical bridge component. A series of experimental tests have been performed under several conditions of flooding levels. The new results unprecedentedly indicate that relatively higher dynamic damping ratios can be found with the increasing flood levels. In contrast, the natural frequencies and dynamic stiffness decrease with the same conditions. Novel insights are essential for bridge engineers to assess and monitor bridge vibrations exposed to extreme weather conditions. FAU - Sengsri, Pasakorn AU - Sengsri P AUID- ORCID: 0000-0003-1876-5207 AD - Laboratory for Track Engineering and Operations for Future Uncertainties (TOFU Lab), School of Engineering, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. FAU - Kaewunruen, Sakdirat AU - Kaewunruen S AUID- ORCID: 0000-0003-2153-3538 AD - Laboratory for Track Engineering and Operations for Future Uncertainties (TOFU Lab), School of Engineering, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. LA - eng GR - 691135/European Commission/ PT - Journal Article DEP - 20230313 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC10055670 OTO - NOTNLM OT - climate change adaptation OT - dynamic modal parameters OT - flood OT - idealised single degree of freedom (ISDOF) OT - novel 3D-printed porous bridge bearings (3DPPBBs) OT - structural dynamics COIS- The authors declare no conflict of interest. EDAT- 2023/03/30 06:00 MHDA- 2023/03/30 06:01 PMCR- 2023/03/13 CRDT- 2023/03/29 01:47 PHST- 2023/02/20 00:00 [received] PHST- 2023/03/10 00:00 [revised] PHST- 2023/03/11 00:00 [accepted] PHST- 2023/03/30 06:01 [medline] PHST- 2023/03/29 01:47 [entrez] PHST- 2023/03/30 06:00 [pubmed] PHST- 2023/03/13 00:00 [pmc-release] AID - ma16062288 [pii] AID - materials-16-02288 [pii] AID - 10.3390/ma16062288 [doi] PST - epublish SO - Materials (Basel). 2023 Mar 13;16(6):2288. doi: 10.3390/ma16062288. PMID- 36266130 OWN - NLM STAT- MEDLINE DCOM- 20221129 LR - 20221202 IS - 1872-6054 (Electronic) IS - 0168-8510 (Linking) VI - 126 IP - 12 DP - 2022 Dec TI - Immediate physical needs of refugees during the Ukrainian armed conflict of 2022. PG - 1303-1309 LID - S0168-8510(22)00277-9 [pii] LID - 10.1016/j.healthpol.2022.10.008 [doi] AB - PURPOSE: The study assessed the physical needs of Ukrainian refugees and internally displaced persons during the ongoing Ukrainian armed conflict of 2022. We aimed to investigate the immediate physical needs of the refugees that may affect their somatic condition during the armed conflict when they did not yet reach their final destination or just reached a safety zone. METHODS: The questionnaire-based prospective repeated cross-sectional study (three study groups) and the longitudinal study (one group) were undertaken in Ukraine and Israel among 19,101 refugees and 828 controls from February 24 to April 9. We assessed the availability of basic somatic necessities (water, food, clothing, hygiene, and sleep) and the general physical fatigue of internal, moving abroad, and arriving to safety refugees with scores ranging from 35 (normal) to 7 (extremely inadequate). RESULTS: The average score of 26.8 ± 1.8 indicates that the participants experienced somatic problems even being healthy. In Ukraine, the score for moving abroad refugees (n = 16,449) dropped from 26.8 ± 0.6 to 23.5 ± 0.6 (p = 0.03) during the study period. Internally displaced persons (n = 1200) remained physically stable with a score of 27.5 ± 0.7. In Israel, group-organized refugees (n = 796) were relatively normal somatically (30.0 ± 0.6) while independent refugees (n = 656) were exhausted having a score of 24.2 ± 0.7 (p = 0.03 vs. group-organized). CONCLUSION: During hostilities, refugees, internally displaced persons, and regular inhabitants are somatically affected but to varying degrees. For refugees, group-organized travel abroad is the best option to maintain adequate physical condition, followed by an internal refugee status, and travel abroad independently (the worst strategy). CI - Copyright © 2022. Published by Elsevier B.V. FAU - Roitblat, Yulia AU - Roitblat Y AD - Science Research Department, Alexander Muss High School in Israel (AMHSI) affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel; Multidisciplinary Social Sciences, Bar Ilan University, Ramat-Gan, Israel. FAU - Nehuliaieva, Liliia AU - Nehuliaieva L AD - Andrei Krupynskyi Lviv Medical Academy, Lviv, Ukraine. FAU - Nedilko, Roksolana AU - Nedilko R AD - Internal Medicine and Healthcare Management of the communal institution of higher education of Lviv Regional Council, Andrey Krupynsky Lviv Medical Academy, Lviv, Ukraine. FAU - Shashkov, Yurii AU - Shashkov Y AD - Andrei Krupynskyi Lviv Medical Academy, Lviv, Ukraine. FAU - Shterenshis, Michael AU - Shterenshis M AD - Science Research Department, Alexander Muss High School in Israel (AMHSI) affiliated with Alexander Muss Institute for Israel Education (AMIIE), Hod HaSharon, Israel. Electronic address: mshterenshis@amhsi.org. LA - eng PT - Journal Article DEP - 20221017 PL - Ireland TA - Health Policy JT - Health policy (Amsterdam, Netherlands) JID - 8409431 MH - Humans MH - *Refugees MH - Cross-Sectional Studies MH - Longitudinal Studies MH - Prospective Studies MH - Fatigue MH - Armed Conflicts OTO - NOTNLM OT - Armed conflict OT - Physical condition OT - Questionnaire survey OT - Refugees COIS- Declaration of Competing Interest None. EDAT- 2022/10/21 06:00 MHDA- 2022/11/30 06:00 CRDT- 2022/10/20 22:04 PHST- 2022/07/06 00:00 [received] PHST- 2022/10/11 00:00 [revised] PHST- 2022/10/14 00:00 [accepted] PHST- 2022/10/21 06:00 [pubmed] PHST- 2022/11/30 06:00 [medline] PHST- 2022/10/20 22:04 [entrez] AID - S0168-8510(22)00277-9 [pii] AID - 10.1016/j.healthpol.2022.10.008 [doi] PST - ppublish SO - Health Policy. 2022 Dec;126(12):1303-1309. doi: 10.1016/j.healthpol.2022.10.008. Epub 2022 Oct 17. PMID- 39759458 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250210 IS - 2769-2558 (Electronic) IS - 2769-2558 (Linking) VI - 4 IP - 1 DP - 2025 Mar TI - Safety of electroconvulsive therapy in the context of physiological and medical complexity: A state-of-the art review. PG - e70051 LID - 10.1002/pcn5.70051 [doi] LID - e70051 AB - Medical contraindications and complications pose challenges for electroconvulsive therapy (ECT). Most published reports are scattered across various physiological systems and individual disease conditions. This review aimed to evaluate the literature on physiological and medical complexities during ECT and discuss risk mitigation strategies in a comprehensive review. We searched PubMed and Embase for contraindications and precautions during ECT with relevant MeSH terms and appraised previous reviews on the same topic. The results suggest that mortality directly attributed to ECT is extremely rare. Instances of fatalities, including fetal deaths, have been reported after ECT in the presence of recent myocardial infarction, deep vein thrombosis, intracranial aneurysm and tumors, pheochromocytoma, sepsis, and pregnancy. However, there are no definite conclusions or consensus on attributions of the outcomes to ECT in all cases because of the time lag between the treatment and deaths and confounding factors. The risks can be mitigated with safety protocols, adequate stakeholder communication, collaboration with anesthetists and specialists, consultation-liaison services, and ECT education. Overall, ECT remains a relatively safe treatment even in the presence of medical and physiological complexities. In rare instances, certain medical conditions may indicate a high risk for ECT, where practitioners avoid the treatment or administer it with precautions if the risk-benefit ratio favors its use. CI - © 2025 The Author(s). Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology. FAU - Elias, Alby AU - Elias A AUID- ORCID: 0000-0002-7494-1028 AD - Department of Psychiatry The University of Melbourne Melbourne Victoria Australia. AD - Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia. FAU - Das, Soumitra AU - Das S AUID- ORCID: 0000-0001-7329-8264 AD - Department of Psychiatry The University of Melbourne Melbourne Victoria Australia. AD - Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia. FAU - Kirkland, James AU - Kirkland J AD - Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia. FAU - Loyal, Sarabjit AU - Loyal S AD - Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia. FAU - Thomas, Naveen AU - Thomas N AUID- ORCID: 0000-0001-6876-1015 AD - Division of Mental Health and Wellbeing Western Health Melbourne Victoria Australia. LA - eng PT - Journal Article PT - Review DEP - 20250103 PL - Australia TA - PCN Rep JT - PCN reports : psychiatry and clinical neurosciences JID - 9918451287106676 PMC - PMC11695668 OTO - NOTNLM OT - ECT OT - electroconvulsive therapy OT - medical complication OT - precaution OT - risk COIS- The authors declare no conflicts of interest. EDAT- 2025/01/06 10:08 MHDA- 2025/01/06 10:09 PMCR- 2025/01/03 CRDT- 2025/01/06 05:37 PHST- 2024/08/04 00:00 [received] PHST- 2024/11/24 00:00 [revised] PHST- 2024/12/14 00:00 [accepted] PHST- 2025/01/06 10:09 [medline] PHST- 2025/01/06 10:08 [pubmed] PHST- 2025/01/06 05:37 [entrez] PHST- 2025/01/03 00:00 [pmc-release] AID - PCN570051 [pii] AID - 10.1002/pcn5.70051 [doi] PST - epublish SO - PCN Rep. 2025 Jan 3;4(1):e70051. doi: 10.1002/pcn5.70051. eCollection 2025 Mar. PMID- 8870111 OWN - NLM STAT- MEDLINE DCOM- 19970103 LR - 20191024 IS - 0049-0172 (Print) IS - 0049-0172 (Linking) VI - 26 IP - 1 DP - 1996 Aug TI - Cyclooxygenase 1 and 2 in rheumatic disease: implications for nonsteroidal anti-inflammatory drug therapy. PG - 435-46 AB - OBJECTIVES: Prostaglandin synthase (cyclooxygenase) is now known to exist in two separate isoforms, termed prostaglandin synthase 1 and 2 (or COX1 and COX2). This has prompted a dramatic increase in research regarding the contribution of these isoforms to inflammatory disease and their relationship to the efficacy and safety of nonsteroidal anti-inflammatory drugs (NSAIDs). The emerging picture is that COX1 is responsible for maintaining prostaglandin synthesis in the gastric mucosa, platelets, and kidney, whereas COX2 is responsible for prostaglandin production in inflamed tissues, including rheumatoid arthritis (RA) synovium. This review examines the validity of the hypothesis that NSAIDs exhibiting selectivity for COX2 demonstrate an improved safety and efficacy profile when compared with NSAIDs exhibiting selectivity for COX1. METHODS: Literature on the efficacy and safety (gastric, renal, and hemostatic) of various NSAIDs are compared with published data on their relative COX1 and COX2 in vitro specificity. RESULTS: No differences in clinical efficacy are evident between NSAIDs exhibiting preferential activity for either COX1 or COX2. NSAIDs representing the extremes in terms of selectivity for COX1 or COX2 do exhibit some differences with respect to gastric, renal, and hemostatic safety; those exhibiting a preferential action on COX2 are generally less toxic than those exhibiting a preferential activity on COX1. Exceptions do exist. CONCLUSIONS: There is some support for the hypothesis that NSAIDs exhibiting a preferential action on COX2 are safer than those exhibiting a preferential activity on COX1, but there exists no support for improved efficacy. A strict correlation does not exist between the COX1 and COX2 specificity and the gastric, renal, and hemostatic toxicity of NSAIDs. This lack of correlation is believed to stem from the fact that both the safety and efficacy of NSAIDs may result from mechanisms distinct from prostaglandin inhibition. Preferential COX2 activity can reduce the level of toxicity for a given NSAID but may not be sufficient to overcome toxicities resulting from other mechanisms. FAU - Spangler, R S AU - Spangler RS AD - Emerging Growth Equities, Wayne, PA 19087, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Semin Arthritis Rheum JT - Seminars in arthritis and rheumatism JID - 1306053 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Isoenzymes) RN - 0 (Membrane Proteins) RN - EC 1.14.99.1 (Cyclooxygenase 1) RN - EC 1.14.99.1 (Cyclooxygenase 2) RN - EC 1.14.99.1 (PTGS1 protein, human) RN - EC 1.14.99.1 (PTGS2 protein, human) RN - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases) SB - IM MH - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology MH - Cyclooxygenase 1 MH - Cyclooxygenase 2 MH - Humans MH - Isoenzymes/*physiology MH - Membrane Proteins MH - Prostaglandin-Endoperoxide Synthases/*physiology MH - Rheumatic Diseases/*drug therapy/*enzymology/physiopathology RF - 79 EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 1996/08/01 00:00 PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] PHST- 1996/08/01 00:00 [entrez] AID - S0049-0172(96)80024-2 [pii] AID - 10.1016/s0049-0172(96)80024-2 [doi] PST - ppublish SO - Semin Arthritis Rheum. 1996 Aug;26(1):435-46. doi: 10.1016/s0049-0172(96)80024-2. PMID- 33081796 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20221207 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 18 IP - 1 DP - 2020 Oct 20 TI - Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants. PG - 398 LID - 10.1186/s12967-020-02568-6 [doi] LID - 398 AB - BACKGROUND: Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants that compromises lung function and necessitates oxygen support. Despite major improvements in perinatal care minimizing the devastating effects, BPD remains the most frequent complication of extreme preterm birth. Our study reports the safety of the allogeneic administration of umbilical cord-derived mesenchymal stem/stromal cells (allo-UC-MSCs) and the progression of lung development in four infants with established BPD. METHODS: UC tissue was collected from a healthy donor, followed by propagation at the Stem Cell Core Facility at Vinmec Research Institute of Stem Cell and Gene Technology. UC-MSC culture was conducted under xeno- and serum-free conditions. Four patients with established BPD were enrolled in this study between May 25, 2018, and December 31, 2018. All four patients received two intravenous doses of allo-UC-MSCs (1 million cells/kg patient body weight (PBW) per dose) with an intervening interval of 7 days. Safety and patient conditions were evaluated during hospitalization and at 7 days and 1, 6 and 12 months postdischarge. RESULTS: No intervention-associated severe adverse events or prespecified adverse events were observed in the four patients throughout the study period. At the time of this report, all patients had recovered from BPD and were weaned off of oxygen support. Chest X-rays and CT scans confirmed the progressive reductions in fibrosis. CONCLUSIONS: Allo-UC-MSC administration is safe in preterm infants with established BPD. Trial registration This preliminary study was approved by the Vinmec International Hospital Ethics Board (approval number: 88/2019/QĐ-VMEC; retrospectively registered March 12, 2019). FAU - Nguyen, Liem Thanh AU - Nguyen LT AD - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Trieu, Thai T H AU - Trieu TTH AD - Vinmec International Hospital-Times City, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Bui, Hue T H AU - Bui HTH AD - Vinmec Hi-Tech Center, Times City, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Hoang, Van T AU - Hoang VT AD - Cellular Manufacturing Department, Vinmec Research Institute of Stem Cell and Gene Technology, 458 Minh Khai, Hai Ba Trung Ward, Hanoi, Vietnam. FAU - Nguyen, Anh T T AU - Nguyen ATT AD - Vinmec Hi-Tech Center, Times City, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Trinh, Nhung T H AU - Trinh NTH AD - Vinmec Hi-Tech Center, Times City, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Nguyen, Kien T AU - Nguyen KT AD - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, Vietnam. FAU - Hoang, Duc M AU - Hoang DM AUID- ORCID: 0000-0001-5444-561X AD - Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Healthcare System, Hanoi, Vietnam. v.duchm3@vinmec.com. AD - Cellular Manufacturing Department, Vinmec Research Institute of Stem Cell and Gene Technology, 458 Minh Khai, Hai Ba Trung Ward, Hanoi, Vietnam. v.duchm3@vinmec.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201020 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Aftercare MH - Asian People MH - *Bronchopulmonary Dysplasia/therapy MH - Female MH - *Hematopoietic Stem Cell Transplantation MH - Humans MH - Infant MH - Infant, Newborn MH - Infant, Premature MH - Patient Discharge MH - Pregnancy MH - *Premature Birth MH - Umbilical Cord PMC - PMC7576694 OTO - NOTNLM OT - Allogeneic mesenchymal stem cell administration OT - Bronchopulmonary dysplasia OT - Umbilical cord tissue COIS- The authors have no competing interests to declare. EDAT- 2020/10/22 06:00 MHDA- 2021/05/15 06:00 PMCR- 2020/10/20 CRDT- 2020/10/21 05:38 PHST- 2020/07/02 00:00 [received] PHST- 2020/10/12 00:00 [accepted] PHST- 2020/10/21 05:38 [entrez] PHST- 2020/10/22 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/10/20 00:00 [pmc-release] AID - 10.1186/s12967-020-02568-6 [pii] AID - 2568 [pii] AID - 10.1186/s12967-020-02568-6 [doi] PST - epublish SO - J Transl Med. 2020 Oct 20;18(1):398. doi: 10.1186/s12967-020-02568-6. PMID- 38394526 OWN - NLM STAT- MEDLINE DCOM- 20240226 LR - 20240810 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 8 DP - 2024 Feb 23 TI - Prevalence of shoulder pain and its correlates in Jeju agricultural population: A retrospective cross-sectional study. PG - e37043 LID - 10.1097/MD.0000000000037043 [doi] LID - e37043 AB - The aim of this study was to investigate the prevalence of shoulder pain and analyze its association with socio-demographic factors, agricultural work-related conditions, and biomechanical factors among farmers on Jeju Island. We utilized initial survey data from the Safety for Agricultural Injury of Farmers' cohort study involving adult farmers on Jeju Island. The presence and characteristics of shoulder pain, socio-demographics, agricultural work-related conditions, and biomechanical factors were assessed using semi-structured questionnaires. A total of 1206 participants were analyzed for prevalence and associated risk factors using frequency and multivariate logistic regression analyses. The overall prevalence of shoulder pain was 17%. Multivariate logistic regression analysis, adjusted for significant socio-demographic and agricultural work-related condition variables, revealed that stress level, type of farming, and experiencing an agricultural injury within the preceding year were significantly associated with shoulder pain (stress level: "occasional," adjusted odds ratio [aOR], 1.581; 95% confidence interval [CI], 1.079-2.318; "frequent," aOR, 1.964; 95% CI, 1.205-3.200; and "extreme," aOR, 2.999; 95% CI, 1.480-6.074 vs "rarely"; type of farming: "orchard," aOR, 0.82; 95% CI, 0.597-1.124; "livestock," aOR, 0.225; 95% CI, 0.079-0.641 vs "field"; and experienced an agricultural injury within the past year: "yes," aOR, 2.078; 95% CI, 1.269-3.405). In addition, 3 biomechanical factors significantly contributed to shoulder pain: activities requiring significant power such as shoveling, pickaxing, and hammering; repetitive use of a particular body part; and constant elevation of the arm above the head. The findings highlight the importance of postural education, injury prevention, and psychological support in managing shoulder pain among farmers. CI - Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Lee, Hyun Jung AU - Lee HJ AD - Department of Physical Medicine and Rehabilitation, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Oh, Jung-Hwan AU - Oh JH AD - Department of Neurology, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Yoo, Jeong Rae AU - Yoo JR AD - Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Ko, Seo Young AU - Ko SY AD - Department of Emergency Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Kang, Jeong Ho AU - Kang JH AD - Department of Emergency Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Lee, Sung Kgun AU - Lee SK AD - Department of Emergency Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Jeong, Wooseong AU - Jeong W AD - Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Seong, Gil Myeong AU - Seong GM AD - Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Kang, Chul-Hoo AU - Kang CH AD - Department of Neurology, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Lim, Chaemoon AU - Lim C AD - Department of Orthopaedic Surgery, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Son, In Seok AU - Son IS AD - Department of Orthopaedic Surgery, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Yang, Hyun Ju AU - Yang HJ AD - Department of Psychiatry, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Oh, Min-Su AU - Oh MS AD - Department of Pediatrics, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. FAU - Song, Sung Wook AU - Song SW AUID- ORCID: 0000-0002-7056-6179 AD - Department of Emergency Medicine, College of Medicine, Jeju National University, Jeju, Republic of Korea. AD - Center for Farmers' Safety and Health, Jeju National University Hospital, Jeju, Republic of Korea. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Adult MH - Humans MH - Cross-Sectional Studies MH - *Shoulder Pain/epidemiology MH - Retrospective Studies MH - Cohort Studies MH - Prevalence MH - *Agriculture MH - Risk Factors PMC - PMC11309677 COIS- The authors have no conflicts of interest to disclose. EDAT- 2024/02/23 18:42 MHDA- 2024/02/26 06:43 PMCR- 2024/02/23 CRDT- 2024/02/23 16:03 PHST- 2024/02/26 06:43 [medline] PHST- 2024/02/23 18:42 [pubmed] PHST- 2024/02/23 16:03 [entrez] PHST- 2024/02/23 00:00 [pmc-release] AID - 00005792-202402230-00045 [pii] AID - 10.1097/MD.0000000000037043 [doi] PST - ppublish SO - Medicine (Baltimore). 2024 Feb 23;103(8):e37043. doi: 10.1097/MD.0000000000037043. PMID- 39411990 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20241016 IS - 2081-3252 (Electronic) IS - 1641-9251 (Linking) VI - 75 IP - 3 DP - 2024 TI - Impact on seafarers of extreme events: A case study arising out of the situation in Ukraine. PG - 190-203 LID - 10.5603/imh.100443 [doi] AB - BACKGROUND: Maritime transportation is the lifeblood of the world's economy. However, seafarers are exposed to isolated, confined and particularly extreme environments. Maritime operations in the face of geopolitical conflicts profoundly impact seafarers' mental health, well-being and safety. MATERIALS AND METHODS: The study comprises 27 seafarer interviews and 21 stakeholder interviews covering 4 maritime education and training institutions, 11 crewing agencies, 4 medical facilities and 2 maritime authorities. An online questionnaire survey of seafarers who were affected by the conflict in Ukraine and had sailed in the conflict zone in the period 24 February 2022 to 30 September 2023 yielded 319 valid responses. RESULTS: The study suggests that seafarers in the conflict zone are exposed to constant imminent threats to personal safety, constant stress and anxiety, prolonged lack of sleep, limited opportunities of contact with families, and high risk to mental health among other things further exacerbated by a lack of mental health support from company, and anxiety resulting from loss of access to shore-based training facilities and uncertainty in updating competency certificates. CONCLUSIONS: The study presents rare insights on the psychological and emotional toll on seafarers who continue to serve the critical needs of the maritime transportation industry in a newly ordained role as keyworkers. This study underscores the need for improved mental health support and counselling services within the maritime industry, in particular, maritime stakeholders likely affected by geopolitical conflicts. HIGHLIGHTS: From the practical perspective, this is among the first studies to focus on the mental health and well-being of seafarers arising out of the situation in Ukraine since 24 February 2022. From the theoretical perspective, this is a maiden study attempting an exploration of social conditions in three different dimensions by integrating three distinct theoretical constructs namely, UN Human Security Framework, Holmes & Rahe Social Readjustment Rating Scale and ILO Maritime Labour Convention framework. FAU - Hebbar, Anish Arvind AU - Hebbar AA AUID- ORCID: 0000-0003-2214-733X AD - World Maritime University, Malmö, Sweden. ah@wmu.se. FAU - Khabeishvili, Teona AU - Khabeishvili T AD - World Maritime University, Malmö, Sweden. LA - eng PT - Journal Article PL - Poland TA - Int Marit Health JT - International maritime health JID - 100958373 SB - IM MH - Humans MH - Ukraine MH - Adult MH - Male MH - Female MH - *Mental Health MH - Naval Medicine MH - Middle Aged MH - Surveys and Questionnaires MH - Ships MH - Armed Conflicts MH - Anxiety MH - Occupational Health OTO - NOTNLM OT - Holmes & Rahe Social Readjustment Rating Scale OT - Holmes & Rahe Stress Scale OT - ILO Maritime Labour Convention OT - Russia-Ukraine conflict OT - UN Human Security Framework OT - extreme event OT - geopolitical conflict OT - maritime safety OT - mental health OT - seafarers OT - well-being EDAT- 2024/10/16 12:23 MHDA- 2024/10/16 12:24 CRDT- 2024/10/16 06:23 PHST- 2024/04/27 00:00 [received] PHST- 2024/05/15 00:00 [accepted] PHST- 2024/05/14 00:00 [revised] PHST- 2024/10/16 12:24 [medline] PHST- 2024/10/16 12:23 [pubmed] PHST- 2024/10/16 06:23 [entrez] AID - VM/OJS/J/100443 [pii] AID - 10.5603/imh.100443 [doi] PST - ppublish SO - Int Marit Health. 2024;75(3):190-203. doi: 10.5603/imh.100443. PMID- 17182643 OWN - NLM STAT- MEDLINE DCOM- 20070515 LR - 20190406 IS - 1470-7926 (Electronic) IS - 1351-0711 (Print) IS - 1351-0711 (Linking) VI - 64 IP - 5 DP - 2007 May TI - Hospital injury rates in relation to socioeconomic status and working conditions. PG - 325-33 AB - OBJECTIVES: To describe the risk of work injury by socioeconomic status (SES) in hospital workers, and to assess whether SES gradient in injury risk is explained by differences in psychosocial, ergonomic or organisational factors at work. METHODS: Workforce rosters and Occupational Safety and Health Administration injury logs for a 5-year period were obtained from two hospitals in Massachusetts. Job titles were classified into five SES strata on the basis of educational requirements and responsibilities: administrators, professionals, semiprofessionals, skilled and semiskilled workers. 13 selected psychosocial, ergonomic and organisational exposures were assigned to the hospital jobs through the national O*NET database. Rates of injury were analysed as frequency records using the Poisson regression, with job title as the unit of analysis. The risk of injury was modelled using SES alone, each exposure variable alone and then each exposure variable in combination with SES. RESULTS: An overall annual injury rate of 7.2 per 100 full-time workers was estimated for the two hospitals combined. All SES strata except professionals showed a significant excess risk of injury compared with the highest SES category (administrators); the risk was highest among semiskilled workers (RR 5.3, p<0.001), followed by nurses (RR 3.7, p<0.001), semiprofessionals (RR 2.9, p = 0.006) and skilled workers (RR 2.6, p = 0.01). The risk of injury was significantly associated with each exposure considered except pause frequency. When workplace exposures were introduced in the regression model together with SES, four remained significant predictors of the risk of injury (decision latitude, supervisor support, force exertion and temperature extremes), whereas the RR related to SES was strongly reduced in all strata, except professionals. CONCLUSIONS: A strong gradient in the risk of injury by SES was reported in a sample population of hospital workers, which was greatly attenuated by adjusting for psychosocial and ergonomic workplace exposures, indicating that a large proportion of that gradient can be explained by differences in working conditions. FAU - d'Errico, A AU - d'Errico A AD - Epidemiology Unit ASL 5-Regione Piemonte, Via Sabaudia 164, Grugliasco (TO) 10095, Italy. angelo.derrico@epi.piemonte.it. FAU - Punnett, L AU - Punnett L FAU - Cifuentes, M AU - Cifuentes M FAU - Boyer, J AU - Boyer J FAU - Tessler, J AU - Tessler J FAU - Gore, R AU - Gore R FAU - Scollin, P AU - Scollin P FAU - Slatin, C AU - Slatin C CN - Promoting Healthy and Safe Employment In Healthcare Research Team LA - eng GR - R01 OH007381/OH/NIOSH CDC HHS/United States GR - R01-OH07381/OH/NIOSH CDC HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20061220 PL - England TA - Occup Environ Med JT - Occupational and environmental medicine JID - 9422759 SB - IM MH - Accidents, Occupational/*statistics & numerical data MH - Adult MH - Age Factors MH - Data Collection MH - Data Interpretation, Statistical MH - Educational Status MH - Employment MH - Female MH - Humans MH - Incidence MH - Italy MH - Male MH - Middle Aged MH - Occupational Health MH - Personnel, Hospital/*statistics & numerical data MH - Residence Characteristics MH - Risk Factors MH - Sex Factors MH - Socioeconomic Factors PMC - PMC2092542 COIS- Competing interests: None. EDAT- 2006/12/22 09:00 MHDA- 2007/05/16 09:00 PMCR- 2010/05/01 CRDT- 2006/12/22 09:00 PHST- 2006/12/22 09:00 [pubmed] PHST- 2007/05/16 09:00 [medline] PHST- 2006/12/22 09:00 [entrez] PHST- 2010/05/01 00:00 [pmc-release] AID - oem.2006.027839 [pii] AID - om27839 [pii] AID - 10.1136/oem.2006.027839 [doi] PST - ppublish SO - Occup Environ Med. 2007 May;64(5):325-33. doi: 10.1136/oem.2006.027839. Epub 2006 Dec 20. PMID- 36125292 OWN - NLM STAT- MEDLINE DCOM- 20230117 LR - 20240910 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 35 IP - 1 DP - 2023 Jan TI - Adverse heat-health outcomes and critical environmental limits (Pennsylvania State University Human Environmental Age Thresholds project). PG - e23801 LID - 10.1002/ajhb.23801 [doi] AB - BACKGROUND: The earth's climate is warming and the frequency, duration, and severity of heat waves are increasing. Meanwhile, the world's population is rapidly aging. Epidemiological data demonstrate exponentially greater increases in morbidity and mortality during heat waves in adults ≥65 years. Laboratory data substantiate the mechanistic underpinnings of age-associated differences in thermoregulatory function. However, the specific combinations of environmental conditions (i.e., ambient temperature and absolute/relative humidity) above which older adults are at increased risk of heat-related morbidity and mortality are less clear. METHODS: This review was conducted to (1) examine the recent (past 3 years) literature regarding heat-related morbidity and mortality in the elderly and discuss projections of future heat-related morbidity and mortality based on climate model data, and (2) detail the background and unique methodology of our ongoing laboratory-based projects aimed toward identifying the specific environmental conditions that result in elevated risk of heat illness in older adults, and the implications of using the data toward the development of evidence-based safety interventions in a continually-warming climate (PSU HEAT; Human Environmental Age Thresholds). RESULTS: The recent literature demonstrates that extreme heat continues to be increasingly detrimental to the health of the elderly and that this is apparent across the world, although the specific environmental conditions above which older adults are at increased risk of heat-related morbidity and mortality remain unclear. CONCLUSION: Characterizing the environmental conditions above which risk of heat-related illnesses increase remains critical to enact policy decisions and mitigation efforts to protect vulnerable people during extreme heat events. CI - © 2022 Wiley Periodicals LLC. FAU - Wolf, S Tony AU - Wolf ST AUID- ORCID: 0000-0002-6336-2143 AD - Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, United States. FAU - Vecellio, Daniel J AU - Vecellio DJ AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, United States. FAU - Kenney, W Larry AU - Kenney WL AD - Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, United States. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, United States. AD - Graduate Program in Physiology, The Pennsylvania State University, University Park, Pennsylvania, United States. LA - eng GR - R01 AG067471/AG/NIA NIH HHS/United States GR - T32 AG049676/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review DEP - 20220920 PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Aged MH - *Hot Temperature MH - Pennsylvania MH - Universities MH - *Extreme Heat/adverse effects MH - Outcome Assessment, Health Care PMC - PMC9840654 MID - NIHMS1834845 COIS- DISCLOSURES No conflicts of interest, financial or otherwise, are declared by the authors. EDAT- 2022/09/21 06:00 MHDA- 2023/01/18 06:00 PMCR- 2024/01/01 CRDT- 2022/09/20 09:03 PHST- 2022/06/24 00:00 [revised] PHST- 2022/05/06 00:00 [received] PHST- 2022/07/29 00:00 [accepted] PHST- 2022/09/21 06:00 [pubmed] PHST- 2023/01/18 06:00 [medline] PHST- 2022/09/20 09:03 [entrez] PHST- 2024/01/01 00:00 [pmc-release] AID - 10.1002/ajhb.23801 [doi] PST - ppublish SO - Am J Hum Biol. 2023 Jan;35(1):e23801. doi: 10.1002/ajhb.23801. Epub 2022 Sep 20. PMID- 35994308 OWN - NLM STAT- Publisher LR - 20231012 IS - 1549-7801 (Electronic) IS - 0738-8551 (Linking) VI - 43 IP - 7 DP - 2023 Dec TI - Advanced diagnostic methods for identification of bacterial foodborne pathogens: contemporary and upcoming challenges. PG - 982-1000 LID - 10.1080/07388551.2022.2095253 [doi] AB - It is a public health imperative to have safe food and water across the population. Foodborne infections are one of the primary causes of sickness and mortality in both developed and developing countries. An estimated 100 million foodborne diseases and 120 000 foodborne illness-related fatalities occur each year in India. Several factors affect foodborne illness, such as improper farming methods, poor sanitary and hygienic conditions at all levels of the food supply chain, the lack of preventative measures in the food processing industry, the misuse of food additives, as well as improper storage and handling. In addition, chemical and microbiological combinations also play a key role in disease development. But recent disease outbreaks indicated that microbial pathogens played a major role in the development of foodborne diseases. Therefore, prompt, rapid, and accurate detection of high-risk food pathogens is extremely vital to warrant the safety of the food items. Conventional approaches for identifying foodborne pathogens are labor-intensive and cumbersome. As a result, a range of technologies for the rapid detection of foodborne bacterial pathogens have been developed. Presently, many methods are available for the instantaneous detection, identification, and monitoring of foodborne pathogens, such as nucleic acid-based methods, biosensor-based methods, and immunological-based methods. The goal of this review is to provide a complete evaluation of several existing and emerging strategies for detecting food-borne pathogens. Furthermore, this review outlines innovative methodologies and their uses in food testing, along with their existing limits and future possibilities in the detection of live pathogens in food. FAU - Panwar, Surbhi AU - Panwar S AD - Department of Genetics and Plant Breeding, Chaudhary Charan Singh University, Meerut, India. FAU - Duggirala, K Siddaardha AU - Duggirala KS AD - Department of Nutrition Biology, Central University of Haryana, Mahendergarh, India. FAU - Yadav, Pooja AU - Yadav P AD - Centre for Molecular Biology, Central University of Jammu, Jammu, India. FAU - Debnath, Nabendu AU - Debnath N AD - Centre for Molecular Biology, Central University of Jammu, Jammu, India. FAU - Yadav, Ashok Kumar AU - Yadav AK AD - Centre for Molecular Biology, Central University of Jammu, Jammu, India. FAU - Kumar, Ashwani AU - Kumar A AD - Department of Nutrition Biology, Central University of Haryana, Mahendergarh, India. LA - eng PT - Journal Article PT - Review DEP - 20220822 PL - England TA - Crit Rev Biotechnol JT - Critical reviews in biotechnology JID - 8505177 SB - IM OTO - NOTNLM OT - Food safety OT - biosensor-based methods OT - food products OT - foodborne pathogens OT - immuno-based techniques OT - nucleic acid-based techniques EDAT- 2022/08/23 06:00 MHDA- 2022/08/23 06:00 CRDT- 2022/08/22 11:43 PHST- 2022/08/23 06:00 [pubmed] PHST- 2022/08/23 06:00 [medline] PHST- 2022/08/22 11:43 [entrez] AID - 10.1080/07388551.2022.2095253 [doi] PST - ppublish SO - Crit Rev Biotechnol. 2023 Dec;43(7):982-1000. doi: 10.1080/07388551.2022.2095253. Epub 2022 Aug 22. PMID- 26116419 OWN - NLM STAT- MEDLINE DCOM- 20160606 LR - 20181202 IS - 1879-3460 (Electronic) IS - 0168-1605 (Linking) VI - 213 DP - 2015 Nov 20 TI - The adaptive response of bacterial food-borne pathogens in the environment, host and food: Implications for food safety. PG - 99-109 LID - S0168-1605(15)30031-3 [pii] LID - 10.1016/j.ijfoodmicro.2015.06.004 [doi] AB - Bacteria are constantly faced to stress situations in their ecological niches, the food and the host gastrointestinal tract. The capacity to detect and respond to surrounding changes is crucial for bacterial pathogens to survive or grow in changing environments. To this purpose, cells have evolved various sophisticated networks designed to protect against stressors or repair damage caused by them. Challenges can occur during production of foods when subjected to processing, and after food ingestion when confronted with host defensive barriers. Some pathogenic bacteria have shown the capacity to develop stable resistance against extreme conditions within a defined genomic context and a limited number of generations. On the other hand, bacteria can also respond to adverse conditions in a transient manner, through the so-called stress tolerance responses. Bacterial stress tolerance responses include both structural and physiological modifications in the cell and are mediated by complex genetic regulatory machinery. Major aspects in the adaptive response are the sensing mechanisms, the characterization of cell defensive systems, such as the operation of regulatory proteins (e.g. RpoS), the induction of homeostatic and repair systems, the synthesis of shock response proteins, and the modifications of cell membranes, particularly in their fatty acid composition and physical properties. This article reviews certain strategies used by food-borne bacteria to respond to particular stresses (acid, cold stress, extreme pressure) in a permanent or transient manner and discusses the implications that such adaptive responses pose for food safety. CI - Copyright © 2015 Elsevier B.V. All rights reserved. FAU - Alvarez-Ordóñez, Avelino AU - Alvarez-Ordóñez A AD - Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland. FAU - Broussolle, Véronique AU - Broussolle V AD - INRA, UMR408 Sécurité et Qualité des Produits d'Origine Végétale, F-84000 Avignon, France; Univ-Avignon, UMR408 Sécurité et Qualité des Produits d'Origine Végétale, F-84000 Avignon, France. FAU - Colin, Pierre AU - Colin P AD - University of Brest, Technopôle Brest-Iroise, Plouzané, France. FAU - Nguyen-The, Christophe AU - Nguyen-The C AD - INRA, UMR408 Sécurité et Qualité des Produits d'Origine Végétale, F-84000 Avignon, France; Univ-Avignon, UMR408 Sécurité et Qualité des Produits d'Origine Végétale, F-84000 Avignon, France. FAU - Prieto, Miguel AU - Prieto M AD - Department of Food Hygiene and Technology, University of León, León, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20150611 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM MH - Adaptation, Physiological/*genetics MH - Animals MH - Bacteria/genetics/*pathogenicity MH - Environment MH - Food Microbiology MH - *Food Safety MH - Foodborne Diseases/*microbiology MH - Gastrointestinal Tract/microbiology MH - *Host-Pathogen Interactions MH - Humans MH - Stress, Physiological/*genetics OTO - NOTNLM OT - Acid OT - Adaptive response OT - Bacillus cereus OT - Cold OT - Mutation OT - SPANC OT - Salmonella OT - Stress EDAT- 2015/06/28 06:00 MHDA- 2016/06/09 06:00 CRDT- 2015/06/28 06:00 PHST- 2015/01/23 00:00 [received] PHST- 2015/05/21 00:00 [revised] PHST- 2015/06/08 00:00 [accepted] PHST- 2015/06/28 06:00 [entrez] PHST- 2015/06/28 06:00 [pubmed] PHST- 2016/06/09 06:00 [medline] AID - S0168-1605(15)30031-3 [pii] AID - 10.1016/j.ijfoodmicro.2015.06.004 [doi] PST - ppublish SO - Int J Food Microbiol. 2015 Nov 20;213:99-109. doi: 10.1016/j.ijfoodmicro.2015.06.004. Epub 2015 Jun 11. PMID- 19702524 OWN - NLM STAT- MEDLINE DCOM- 20091109 LR - 20190911 IS - 1873-5592 (Electronic) IS - 1389-4501 (Linking) VI - 10 IP - 8 DP - 2009 Aug TI - Treating nonthyroidal illness syndrome in the critically ill patient: still a matter of controversy. PG - 778-87 AB - The nonthyroidal illness syndrome (NTIS) is a clinical condition of abnormal thyroid function tests observed in patients with acute or chronic systemic illnesses. The laboratory parameters of NTIS usually include low serum levels of triiodothyronine, with normal or low levels of thyroxine and normal or low levels of thyroid-stimulating hormone. It is still a matter of controversy whether the NTIS represents a protective adaptation of the organism to a stressful event or a maladaptive response to illness that needs correction. Multiple studies have investigated the effect of thyroid hormone replacement therapy in certain clinical situations, such as caloric restriction, cardiac disease, acute renal failure, brain-dead potential donors, and burn patients. Treating patients with NTIS seems not to be harmful, but there is no persuasive evidence that it is beneficial. The administration of hypothalamic releasing factors in patients with NTIS appears to be safe and effective in improving metabolism and restoring the anterior pituitary pulsatile secretion in the chronic phase of critical illness. However, also this promising strategy needs to be explored further. Anyhow, an extremely prudent approach is needed if treatment is given. Much of the data appearing in the literature on the treatment of NTIS encourage further randomized controlled trials on large number of patients. At present, however, we believe that there is no indication for treating thyroid hormone abnormalities in critically ill patients until convincing proof of efficacy and safety is provided. FAU - Bello, G AU - Bello G AD - Department of Anesthesiology and Intensive Care, Università Cattolica del Sacro Cuore, Policlinico Universitario A. Gemelli, Rome, Italy. gbello.gb@libero.it FAU - Paliani, G AU - Paliani G FAU - Annetta, M G AU - Annetta MG FAU - Pontecorvi, A AU - Pontecorvi A FAU - Antonelli, M AU - Antonelli M LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Drug Targets JT - Current drug targets JID - 100960531 SB - IM MH - *Critical Illness MH - Humans MH - Thyroid Gland/*physiopathology RF - 101 EDAT- 2009/08/26 09:00 MHDA- 2009/11/10 06:00 CRDT- 2009/08/26 09:00 PHST- 2009/08/26 09:00 [entrez] PHST- 2009/08/26 09:00 [pubmed] PHST- 2009/11/10 06:00 [medline] AID - 10.2174/138945009788982414 [doi] PST - ppublish SO - Curr Drug Targets. 2009 Aug;10(8):778-87. doi: 10.2174/138945009788982414. PMID- 8098636 OWN - NLM STAT- MEDLINE DCOM- 19930623 LR - 20220409 IS - 0962-7480 (Print) IS - 0962-7480 (Linking) VI - 43 IP - 2 DP - 1993 May TI - Shoe concerns and foot problems of wearers of safety footwear. PG - 73-7 AB - In Australia workers in many industries are required to wear safety footwear (footwear incorporating a steel toe cap). An investigation of the problems reported by 321 workers (70 per cent male) employed in a broad range of work activities and required to wear safety footwear was conducted in 1990 and 1991. Respondents were interviewed by a professionally trained podiatrist using a structured questionnaire followed by a foot examination. An extremely high percentage (91 per cent) of subjects reported one or more foot problems (which were verified by the podiatrist), and most considered that the safety footwear either caused the problem or adversely affected an existing foot condition. The main shoe concerns reported were excessive heat (65 per cent of all respondents), inflexible soles (52 per cent), weight (48 per cent) and pressure from steel toe cap (47 per cent). Certain gender differences were identified. General recommendations are made. FAU - Marr, S J AU - Marr SJ AD - Faculty of Medicine, University of Sydney, Australia. FAU - Quine, S AU - Quine S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Occup Med (Lond) JT - Occupational medicine (Oxford, England) JID - 9205857 SB - IM MH - Accidents, Occupational/statistics & numerical data MH - Adult MH - Female MH - Foot Diseases/epidemiology/*etiology MH - *Foot Injuries MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Occupational Diseases/*etiology MH - Protective Clothing/*adverse effects MH - Shoes/*adverse effects EDAT- 1993/05/01 00:00 MHDA- 1993/05/01 00:01 CRDT- 1993/05/01 00:00 PHST- 1993/05/01 00:00 [pubmed] PHST- 1993/05/01 00:01 [medline] PHST- 1993/05/01 00:00 [entrez] AID - 10.1093/occmed/43.2.73 [doi] PST - ppublish SO - Occup Med (Lond). 1993 May;43(2):73-7. doi: 10.1093/occmed/43.2.73. PMID- 24977848 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150417 LR - 20181023 IS - 1094-4087 (Electronic) IS - 1094-4087 (Linking) VI - 22 IP - 13 DP - 2014 Jun 30 TI - Opto-mechanisms design of extreme-ultraviolet camera onboard Chang E lunar lander. PG - 15932-40 LID - 10.1364/OE.22.015932 [doi] AB - The extreme-ultraviolet camera mounted on the Lander of China Chang-E lunar exploration project launched in 2013 is the first instrument used to imaging from the lunar surface to the whole plasmasphere around the earth. Taking into account both the lunar environment conditions and the weight and volume constraints, a single spherical mirror and a spherical microchannel plate detector make up the compact optical system. An optimized opto-mechanical design was presented using Finite Element Analysis Model, and the detail design for the important assemblies of the 2-axis platform, the primary mirror, the aperture door mechanism and MCP detector were all specially addressed for their environmental adaptability and reliability. Tests of mechanical characteristics have demonstrated that the position and pointing accuracy and its stability meets the operation requirements of 2'. Vibration results have shown that the EUVC has adequate stiffness and strength safety margin to survive in launch and the moon environments. The imaging performance with the resolution of 0.08° is measured after vibration, in agreement with the predicted performance. FAU - Li, Zhaohui AU - Li Z FAU - Chen, Bo AU - Chen B FAU - Song, Kefei AU - Song K FAU - Wang, Xiaodong AU - Wang X FAU - Liu, Shijie AU - Liu S FAU - Yang, Liang AU - Yang L FAU - Hu, Qinglong AU - Hu Q FAU - Qiao, Ke AU - Qiao K FAU - Zhang, Liping AU - Zhang L FAU - Wu, Guodong AU - Wu G FAU - Yu, Ping AU - Yu P LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Opt Express JT - Optics express JID - 101137103 EDAT- 2014/07/01 06:00 MHDA- 2014/07/01 06:01 CRDT- 2014/07/01 06:00 PHST- 2014/07/01 06:00 [entrez] PHST- 2014/07/01 06:00 [pubmed] PHST- 2014/07/01 06:01 [medline] AID - 294207 [pii] AID - 10.1364/OE.22.015932 [doi] PST - ppublish SO - Opt Express. 2014 Jun 30;22(13):15932-40. doi: 10.1364/OE.22.015932. PMID- 38197689 OWN - NLM STAT- MEDLINE DCOM- 20240111 LR - 20241216 IS - 2078-6204 (Electronic) IS - 2078-6190 (Print) IS - 2078-6190 (Linking) VI - 65 IP - 1 DP - 2023 Dec 22 TI - The psychological impact of COVID-19 on frontline doctors in Tshwane public hospitals. PG - e1-e10 LID - 10.4102/safp.v65i1.5807 [doi] LID - 5807 AB - BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic placed immense pressure on frontline doctors. Burnout is a psychological syndrome that develops in response to chronic work stress. It consists of emotional exhaustion (EE), depersonalisation (DP) and reduced personal accomplishment (PA). Burnout is associated with personal dysfunction and compromises the work profession and patient safety. International studies suggest burnout is exacerbated during a pandemic. METHODS: We conducted a descriptive cross-sectional observational study. Respondents included frontline doctors working in emergency medicine, family medicine and internal medicine during COVID-19 in Tshwane public hospitals. The survey included two validated questionnaires, the Maslach Burnout Inventory and the Depression, Anxiety, Stress Scale-21. The aim was to determine the prevalence and severity of burnout, psychological and somatic symptoms in frontline doctors. RESULTS: Of the 163 participants, we found clinical burnout to be present in 58.9% (n = 96) and extreme burnout in 19.6% (n = 32). Moderate to extremely severe levels of stress, anxiety and depression were present in 55.1% (n = 90), 43.6% (n = 71) and 22.1% (n = 36) of participants, respectively. We found significant correlations between burnout and psychological symptoms. Increased levels of burnout, anxiety, depression and stress were found to be meaningfully associated with adverse somatic symptoms. CONCLUSION: Our study demonstrated an insufferably high prevalence of burnout and psychosomatic symptoms in frontline doctors during COVID-19. In the event of future pandemics, more measures should be taken to support frontline doctors.Contribution: Pandemic-associated burnout and its psychophysical consequences have not been studied in frontline doctors in South Africa. FAU - Duffton, Juliet D AU - Duffton JD AD - Department of Family Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria. drjulietreed@gmail.com. FAU - Heystek, Marthinus J AU - Heystek MJ FAU - Engelbrecht, Andreas AU - Engelbrecht A FAU - Rajan, Suma AU - Rajan S FAU - Du Toit, Renier A AU - Du Toit RA LA - eng PT - Journal Article PT - Observational Study DEP - 20231222 PL - South Africa TA - S Afr Fam Pract (2004) JT - South African family practice : official journal of the South African Academy of Family Practice/Primary Care JID - 9701104 RN - Maslach Burnout Inventory SB - IM MH - *COVID-19/epidemiology MH - Self Report MH - *Medically Unexplained Symptoms MH - Humans MH - Hospitals, Public MH - Psychological Tests MH - Cross-Sectional Studies PMC - PMC10784208 OTO - NOTNLM OT - COVID-19 OT - South Africa OT - anxiety OT - burnout OT - depression OT - doctors OT - frontline OT - pandemic OT - psychological OT - somatic symptoms OT - stress COIS- The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article. EDAT- 2024/01/10 12:43 MHDA- 2024/01/11 07:42 PMCR- 2023/12/22 CRDT- 2024/01/10 09:14 PHST- 2023/08/02 00:00 [received] PHST- 2023/10/18 00:00 [accepted] PHST- 2023/10/18 00:00 [revised] PHST- 2024/01/11 07:42 [medline] PHST- 2024/01/10 12:43 [pubmed] PHST- 2024/01/10 09:14 [entrez] PHST- 2023/12/22 00:00 [pmc-release] AID - SAFP-65-5807 [pii] AID - 10.4102/safp.v65i1.5807 [doi] PST - epublish SO - S Afr Fam Pract (2004). 2023 Dec 22;65(1):e1-e10. doi: 10.4102/safp.v65i1.5807. PMID- 39532779 OWN - NLM STAT- MEDLINE DCOM- 20241126 LR - 20241204 IS - 1573-904X (Electronic) IS - 0724-8741 (Linking) VI - 41 IP - 11 DP - 2024 Nov TI - Pharmacological Innovations in Space: Challenges and Future Perspectives. PG - 2095-2120 LID - 10.1007/s11095-024-03788-x [doi] AB - PURPOSE: Since the first human experience in space, the interest in space research and medicine to explore universe is growing day by day. The extreme space conditions mainly radiation and microgravity effects on human physiology, antimicrobial susceptibility, and efficacy, safety, and stability of drugs. Therefore, the aim of this review is to address the impact of extreme space conditions, mainly microgravity and radiation, on human physiology and highlights the need for future approaches by evaluating the effectiveness of strategies to prevent or mitigate health problems. METHODS: Published papers and NASA technical documents were searched in Pubmed and Google Scholar databases using the keywords ''antimicrobial susceptibility or drug resistance or drug stability or innovations or pharmacokinetic or pharmacodynamics'' and ''radiation or microgravity or space environments or space medicine or space pharmacy'' to prepare this review. RESULTS: In this review, the challenges regarding physiological effects and drug-related problems are examined through the evaluation of extreme conditions in space. Medications used in spaceflight are summarized, and the role of pharmacists specializing in space medicine is briefly explained. Last but not least, to overcome the aforementioned issues, novel approaches have been addressed, such as personalised treatments, development of space-resistant formulations and various microbial applications. CONCLUSIONS: Further research in the space medicine is required to facilitate the safe and healthy travel of humans to the Moon, Mars and other extraterrestrial destinations. One bear in mind that space research will contribute not only to the exploration of the universe, but also to the advancement of health and technological discoveries on Earth. CI - © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Aksoyalp, Zinnet Şevval AU - Aksoyalp ZŞ AUID- ORCID: 0000-0002-7822-3154 AD - Department of Pharmacology, Faculty of Pharmacy, Izmir Katip Celebi University, 35620, Izmir, Türkiye. FAU - Temel, Aybala AU - Temel A AUID- ORCID: 0000-0003-1549-7219 AD - Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Izmir Katip Celebi University, 35620, Izmir, Türkiye. FAU - Karpuz, Merve AU - Karpuz M AUID- ORCID: 0000-0001-6681-2448 AD - Department of Radiopharmacy, Faculty of Pharmacy, Izmir Katip Celebi University, 35620, Izmir, Türkiye. merve.karpuz@ikcu.edu.tr. LA - eng PT - Journal Article PT - Review DEP - 20241112 PL - United States TA - Pharm Res JT - Pharmaceutical research JID - 8406521 RN - 0 (Pharmaceutical Preparations) SB - IM MH - Humans MH - *Space Flight MH - *Weightlessness MH - Aerospace Medicine/methods/trends MH - Animals MH - Pharmaceutical Preparations MH - Pharmacists OTO - NOTNLM OT - Antimicrobial OT - Astropharmacy OT - Drug resistance OT - Drug stabilities OT - Innovation OT - Microgravity OT - Radiation OT - Space medicine COIS- Declarations. Conflicts of Interest: The authors have no conflicts of interest to declare. EDAT- 2024/11/13 13:51 MHDA- 2024/11/27 00:20 CRDT- 2024/11/12 23:21 PHST- 2024/08/18 00:00 [received] PHST- 2024/10/17 00:00 [accepted] PHST- 2024/11/27 00:20 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/12 23:21 [entrez] AID - 10.1007/s11095-024-03788-x [pii] AID - 10.1007/s11095-024-03788-x [doi] PST - ppublish SO - Pharm Res. 2024 Nov;41(11):2095-2120. doi: 10.1007/s11095-024-03788-x. Epub 2024 Nov 12. PMID- 33045763 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20220517 IS - 1442-200X (Electronic) IS - 1328-8067 (Linking) VI - 63 IP - 7 DP - 2021 Jul TI - Efficacy and safety of sclerotherapy with polidocanol in children with internal hemorrhoids. PG - 813-817 LID - 10.1111/ped.14506 [doi] AB - BACKGROUND: Hemorrhoids are an extremely rare condition in children, and data on its incidence and treatment in the pediatric population remains scarce. We retrospectively reviewed children who underwent sclerotherapy for internal hemorrhoids, and analyzed patients' characteristics and outcomes. METHODS: A total of 14 pediatric patients who underwent sclerotherapy were included. Patients' ages and the required amount of polidocanol, depending on the grade of hemorrhoids, and the correlation between age and volume of sclerosant, were statistically analyzed. RESULTS: Patients had a male predominance with a ratio of 2.5:1 (grade 2:6 patients, grade 3:8 patients). Four children had underlying conditions including portal hypertension and Klippel-Trenaunay syndrome. Of the 14 patients, 43% had constipation requiring medication or enema. Only one minor complication, a perianal ulceration, was found to be associated with sclerotherapy. Patients with grade 3 hemorrhoids required a significantly larger amount of polidocanol than those with grade 2 hemorrhoids. Two patients with grade 3 hemorrhoids required a second session of treatment for recurrence. The success rate of sclerotherapy with polidocanol was 86%. CONCLUSIONS: Sclerotherapy with polidocanol is a safe, effective, and less invasive treatment option for internal hemorrhoids in children. Further studies are needed to investigate this treatment approach. CI - © 2020 Japan Pediatric Society. FAU - Watanabe, Toshihiko AU - Watanabe T AUID- ORCID: 0000-0003-4096-4990 AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. AD - Department of Pediatric Surgery, Tokai University School of Medicine, Kanagawa, Japan. FAU - Ohno, Michinobu AU - Ohno M AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Tahara, Kazunori AU - Tahara K AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Tomonaga, Kotaro AU - Tomonaga K AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Ogawa, Katsuhiro AU - Ogawa K AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Takezoe, Toshiko AU - Takezoe T AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Fuchimoto, Yasushi AU - Fuchimoto Y AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Fujino, Akihiro AU - Fujino A AUID- ORCID: 0000-0003-2987-5081 AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. FAU - Kanamori, Yutaka AU - Kanamori Y AUID- ORCID: 0000-0001-7609-0426 AD - Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20210526 PL - Australia TA - Pediatr Int JT - Pediatrics international : official journal of the Japan Pediatric Society JID - 100886002 RN - 0 (Sclerosing Solutions) RN - 0AWH8BFG9A (Polidocanol) RN - 3WJQ0SDW1A (Polyethylene Glycols) SB - IM CIN - Pediatr Int. 2022 Jan;64(1):e15165. doi: 10.1111/ped.15165. PMID: 35522250 MH - Child MH - *Hemorrhoids/drug therapy MH - Humans MH - Male MH - Polidocanol MH - Polyethylene Glycols/adverse effects MH - Retrospective Studies MH - Sclerosing Solutions/therapeutic use MH - *Sclerotherapy/adverse effects MH - Treatment Outcome OTO - NOTNLM OT - child OT - hemorrhoid OT - polidocanol OT - sclerotherapy EDAT- 2020/10/13 06:00 MHDA- 2021/08/19 06:00 CRDT- 2020/10/12 20:16 PHST- 2020/09/23 00:00 [revised] PHST- 2020/05/04 00:00 [received] PHST- 2020/10/07 00:00 [accepted] PHST- 2020/10/13 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2020/10/12 20:16 [entrez] AID - 10.1111/ped.14506 [doi] PST - ppublish SO - Pediatr Int. 2021 Jul;63(7):813-817. doi: 10.1111/ped.14506. Epub 2021 May 26. PMID- 30486240 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20181211 LR - 20200225 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 18 IP - 12 DP - 2018 Nov 26 TI - Model Updating for Nam O Bridge Using Particle Swarm Optimization Algorithm and Genetic Algorithm. LID - 10.3390/s18124131 [doi] LID - 4131 AB - Vibration-based structural health monitoring (SHM) for long-span bridges has become a dominant research topic in recent years. The Nam O Railway Bridge is a large-scale steel truss bridge located on the unique main rail track from the north to the south of Vietnam. An extensive vibration measurement campaign and model updating are extremely necessary to build a reliable model for health condition assessment and operational safety management of the bridge. The experimental measurements are carried out under ambient vibrations using piezoelectric sensors, and a finite element (FE) model is created in MATLAB to represent the physical behavior of the structure. By model updating, the discrepancies between the experimental and the numerical results are minimized. For the success of the model updating, the efficiency of the optimization algorithm is essential. Particle swarm optimization (PSO) algorithm and genetic algorithm (GA) are employed to update the unknown model parameters. The result shows that PSO not only provides a better accuracy between the numerical model and measurements, but also reduces the computational cost compared to GA. This study focuses on the stiffness conditions of typical joints of truss structures. According to the results, the assumption of semi-rigid joints (using rotational springs) can most accurately represent the dynamic characteristics of the truss bridge considered. FAU - Tran-Ngoc, H AU - Tran-Ngoc H AD - Department of Electrical Energy, Metals, Mechanical Constructions, and Systems, Faculty of Engineering and Architecture, Ghent University, 9000 Gent, Belgium. ngochoa@utc.edu.vn. AD - Department of Bridge and Tunnel Engineering, Faculty of Civil Engineering, University of Transport and Communications, Hanoi, Vietnam. ngochoa@utc.edu.vn. FAU - Khatir, S AU - Khatir S AD - Department of Electrical Energy, Metals, Mechanical Constructions, and Systems, Faculty of Engineering and Architecture, Ghent University, 9000 Gent, Belgium. khatir_samir@hotmail.fr. FAU - De Roeck, G AU - De Roeck G AD - KU Leuven, Department of Civil Engineering, B-3001 Leuven, Belgium. guido.deroeck@kuleuven.be. FAU - Bui-Tien, T AU - Bui-Tien T AD - Department of Bridge and Tunnel Engineering, Faculty of Civil Engineering, University of Transport and Communications, Hanoi, Vietnam. btthanh@utc.edu.vn. FAU - Nguyen-Ngoc, L AU - Nguyen-Ngoc L AD - Department of Bridge and Tunnel Engineering, Faculty of Civil Engineering, University of Transport and Communications, Hanoi, Vietnam. longnguyen@utc.edu.vn. FAU - Abdel Wahab, M AU - Abdel Wahab M AD - Institute of Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, Vietnam. magd.abdelwahab@ugent.be. AD - Soete Laboratory, Faculty of Engineering and Architecture, Ghent University, Technologiepark Zwijnaarde 903, B-9052 Zwijnaarde, Belgium. magd.abdelwahab@ugent.be. LA - eng GR - VN2018TEA479A103/Vlaamse Interuniversitaire Raad/ PT - Journal Article DEP - 20181126 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 PMC - PMC6308408 OTO - NOTNLM OT - genetic algorithm OT - large-scale bridges OT - model updating OT - particle swarm optimization OT - stiffness of truss joints COIS- The authors declare no conflict of interest. EDAT- 2018/11/30 06:00 MHDA- 2018/11/30 06:01 PMCR- 2018/12/01 CRDT- 2018/11/30 06:00 PHST- 2018/10/29 00:00 [received] PHST- 2018/11/20 00:00 [revised] PHST- 2018/11/21 00:00 [accepted] PHST- 2018/11/30 06:00 [entrez] PHST- 2018/11/30 06:00 [pubmed] PHST- 2018/11/30 06:01 [medline] PHST- 2018/12/01 00:00 [pmc-release] AID - s18124131 [pii] AID - sensors-18-04131 [pii] AID - 10.3390/s18124131 [doi] PST - epublish SO - Sensors (Basel). 2018 Nov 26;18(12):4131. doi: 10.3390/s18124131. PMID- 37895998 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240928 IS - 2223-7747 (Print) IS - 2223-7747 (Electronic) IS - 2223-7747 (Linking) VI - 12 IP - 20 DP - 2023 Oct 11 TI - Establishment of an Efficient and Rapid Regeneration System for a Rare Shrubby Desert Legume Eremosparton songoricum. LID - 10.3390/plants12203535 [doi] LID - 3535 AB - Eremosparton songoricum (Litv.) Vass. is a rare and extremely drought-tolerant legume shrub that is distributed in Central Asia. E. songoricum naturally grows on bare sand and can tolerate multiple extreme environmental conditions. It is a valuable and important plant resource for desertification prevention and environmental protection, as well as a good material for the exploration of stress tolerance mechanisms and excellent tolerant gene mining. However, the regeneration system for E. songoricum has not yet been established, which markedly limits the conservation and utilization of this endangered and valuable desert legume. Assimilated branches derived from seedlings were cultured on several MS mediums supplemented with various concentrations of TDZ or 6-BA in different combinations with NAA. The results showed that the most efficient multiplication medium was MS medium supplemented with 0.4 mg/L 6-BA and 0.1 mg/L NAA. The most efficient rooting medium was WPM + 25 g/L sucrose. The highest survival rate (77.8%) of transplantation was achieved when the ratio of sand to vermiculite was 1:1. In addition, the optimal callus induction medium was MS + 30 g/L sucrose + 2 mg/L TDZ + 0.5 mg/L NAA in darkness. The E. songoricum callus treated with 100 mM NaCl and 300 mM mannitol on MS medium could be used in proper salt and drought stress treatments in subsequent gene function tests. A rapid and efficient regeneration system for E. songoricum that allowed regeneration within 3 months was developed. The protocol will contribute to the conservation and utilization of this rare and endangered desert stress-tolerant species and also provide a fundamental basis for gene functional analysis in E. songoricum. FAU - Qiao, Siqi AU - Qiao S AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Jin, Pei AU - Jin P AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Liu, Xiaojie AU - Liu X AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - Turpan Eremophytes Botanical Garden, Chinese Academy of Sciences, Turpan 838008, China. FAU - Liang, Yuqing AU - Liang Y AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - Turpan Eremophytes Botanical Garden, Chinese Academy of Sciences, Turpan 838008, China. FAU - Yang, Ruirui AU - Yang R AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Bai, Wenwan AU - Bai W AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Zhang, Daoyuan AU - Zhang D AUID- ORCID: 0000-0001-5026-7617 AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - Turpan Eremophytes Botanical Garden, Chinese Academy of Sciences, Turpan 838008, China. FAU - Li, Xiaoshuang AU - Li X AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - Turpan Eremophytes Botanical Garden, Chinese Academy of Sciences, Turpan 838008, China. LA - eng PT - Journal Article DEP - 20231011 PL - Switzerland TA - Plants (Basel) JT - Plants (Basel, Switzerland) JID - 101596181 PMC - PMC10610040 OTO - NOTNLM OT - Eremosparton songoricum OT - callus OT - desert legume OT - hormone concentration OT - regeneration OT - tissue culture COIS- The authors declare that they have no conflict of interest. EDAT- 2023/10/28 11:48 MHDA- 2023/10/28 11:49 PMCR- 2023/10/11 CRDT- 2023/10/28 01:24 PHST- 2023/08/30 00:00 [received] PHST- 2023/09/26 00:00 [revised] PHST- 2023/10/05 00:00 [accepted] PHST- 2023/10/28 11:49 [medline] PHST- 2023/10/28 11:48 [pubmed] PHST- 2023/10/28 01:24 [entrez] PHST- 2023/10/11 00:00 [pmc-release] AID - plants12203535 [pii] AID - plants-12-03535 [pii] AID - 10.3390/plants12203535 [doi] PST - epublish SO - Plants (Basel). 2023 Oct 11;12(20):3535. doi: 10.3390/plants12203535. PMID- 22753199 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20120831 LR - 20141212 IS - 1833-3516 (Print) IS - 1833-3516 (Linking) VI - 39 IP - 2 DP - 2009 Jun TI - Hyperbaric chamber attendant safety II: 14-year health review of multiplace chamber attendants. PG - 71-6 AB - INTRODUCTION: The multiplace hyperbaric chamber provides a unique working environment for health-care personnel. The major foci of concern regarding staff health under these conditions have tended to be decompression sickness (DCS) and barotrauma. Incidences of DCS as high as 1.3% have been reported in hyperbaric attendants exposed to routine treatment tables. Occupational health risks of this magnitude are not acceptable in routine clinical practice. Significant variations in procedures exist between institutions in an attempt to enhance staff safety. In extreme cases the use of multiplace chambers has been abandoned. AIM: To determine the actual incidence of work-related health issues amongst attendants at a full-time clinical hyperbaric unit. DESIGN: retrospective staff health survey. Facility: university teaching hospital. SUBJECTS: 155 medical, nursing and technical staff routinely exposed to hyperbaric conditions. RESULTS: There were no cases of DCS encountered in 6,062 attendant exposures, across all hyperbaric profiles, during this 14-year period (95% CI 0, 0.06%). Twenty-eight work-related injuries occurred during this time (0.46%), of which 25 (0.41%) were hyperbaric-specific. CONCLUSION: A multiplace hyperbaric chamber can be viewed as a relatively safe working environment. FAU - Cooper, P David AU - Cooper PD AD - Royal Hobart Hospital, Hobart, Australia. david.cooper@dhhs.tas.gov.au FAU - Van den Broek, Corry AU - Van den Broek C FAU - Smart, David R AU - Smart DR LA - eng PT - Journal Article PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 EDAT- 2009/06/01 00:00 MHDA- 2009/06/01 00:01 CRDT- 2012/07/04 06:00 PHST- 2008/12/03 00:00 [received] PHST- 2009/03/31 00:00 [accepted] PHST- 2012/07/04 06:00 [entrez] PHST- 2009/06/01 00:00 [pubmed] PHST- 2009/06/01 00:01 [medline] PST - ppublish SO - Diving Hyperb Med. 2009 Jun;39(2):71-6. PMID- 38081752 OWN - NLM STAT- MEDLINE DCOM- 20240417 LR - 20240417 IS - 1521-186X (Electronic) IS - 0197-8462 (Linking) VI - 45 IP - 4 DP - 2024 May TI - Quantitative analyses of RBC movement in whole blood exposed to DC and ELF electric field. PG - 159-170 LID - 10.1002/bem.22493 [doi] AB - For the study of biological effects of direct current (DC) and extremely low frequency (ELF) electric fields, we have quantitatively analyzed red blood cell (RBC) movement in whole blood. Considering the inhomogeneous distribution of electric fields in vivo, five different electric field distributions were generated under a microscope. For theoretical analyses, we assumed electrophoresis and dielectrophoresis as basic motive forces and obtained the spatial distribution of blood cell velocity. The RBC velocity was measured using video image analysis. The spatial dependence of the velocity showed good agreement with that predicted by theoretical analysis. This result suggests the validity of the theoretical model based on electrophoresis and dielectrophoresis for the study of ELF electric field exposure to inhomogeneous animal and human bodies. Next, using the same measurement system, we attempted to find the electric field strength at which these effects occur. The threshold values were found to be 0.40 and 1.6 kV/m, respectively, for DC and AC electric field exposures. Furthermore, we investigated the reproducibility of the field effects in more realistic conditions of human exposure. The RBCs in microchannels were exposed to the electric field generated in capacitive coupling using electrodes separated by an air gap. Even in the new condition, similar effects were observed, which also verified the validity of the analysis described above. These results will provide useful information for the safety assessment of field exposure and for the future biomedical applications of electric fields to manipulate RBCs in vivo. CI - © 2023 The Authors. Bioelectromagnetics published by Wiley Periodicals LLC on behalf of Bioelectromagnetics Society. FAU - Kanemaki, Miki AU - Kanemaki M AUID- ORCID: 0000-0003-1424-6039 AD - Graduate School of Information, Production and Systems, Waseda University, Kitakyushu, Japan. FAU - Shimizu, Hisae O AU - Shimizu HO AD - Graduate School of Health Science, Hokkaido University of Science, Sapporo, Japan. FAU - Inujima, Hiroshi AU - Inujima H AD - Graduate School of Information, Production and Systems, Waseda University, Kitakyushu, Japan. FAU - Miyake, Takeo AU - Miyake T AD - Graduate School of Information, Production and Systems, Waseda University, Kitakyushu, Japan. FAU - Shimizu, Koichi AU - Shimizu K AD - School of Optoelectronic Engineering, Xidian University, Xi'an, China. LA - eng GR - 20K20537/Grants-in-Aid for Scientific Research from the Japan Society/ PT - Journal Article DEP - 20231211 PL - United States TA - Bioelectromagnetics JT - Bioelectromagnetics JID - 8008281 SB - IM MH - Animals MH - Humans MH - *Electromagnetic Fields/adverse effects MH - Reproducibility of Results MH - *Erythrocytes MH - Electricity MH - Models, Theoretical OTO - NOTNLM OT - ELF electric field OT - biological effects OT - dielectrophoresis OT - electrophoresis OT - red blood cell OT - whole blood EDAT- 2023/12/12 00:42 MHDA- 2024/04/17 06:42 CRDT- 2023/12/11 21:42 PHST- 2023/08/11 00:00 [revised] PHST- 2023/04/05 00:00 [received] PHST- 2023/11/02 00:00 [accepted] PHST- 2024/04/17 06:42 [medline] PHST- 2023/12/12 00:42 [pubmed] PHST- 2023/12/11 21:42 [entrez] AID - 10.1002/bem.22493 [doi] PST - ppublish SO - Bioelectromagnetics. 2024 May;45(4):159-170. doi: 10.1002/bem.22493. Epub 2023 Dec 11. PMID- 24725485 OWN - NLM STAT- MEDLINE DCOM- 20140603 LR - 20140414 IS - 1558-318X (Electronic) IS - 0094-0143 (Linking) VI - 41 IP - 2 DP - 2014 May TI - Evolution and immediate future of US screening guidelines. PG - 229-35 LID - S0094-0143(14)00006-8 [pii] LID - 10.1016/j.ucl.2014.01.005 [doi] AB - Although observational studies and simulation models have shed some interesting light on many of the uncertainties surrounding prostate cancer screening, well-done clinical trials provide the best evidence on screening among the extremes of age, the most appropriate interval to screen, and the best complement of tests to use. Enthusiasm for screening is temporized by the acknowledgment that overdetection leads to frequent overtreatment despite evidence supporting the safety of active surveillance in many men with low-risk disease. CI - Copyright © 2014 Elsevier Inc. All rights reserved. FAU - Greene, Kirsten L AU - Greene KL AD - Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1600 Divisadero Street, A631, San Francisco, CA 94115, USA. Electronic address: kgreene@urology.ucsf.edu. FAU - Punnen, Sanoj AU - Punnen S AD - Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1600 Divisadero Street, A631, San Francisco, CA 94115, USA. FAU - Carroll, Peter R AU - Carroll PR AD - Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 1600 Divisadero Street, A631, San Francisco, CA 94115, USA. LA - eng PT - Journal Article PT - Review PL - United States TA - Urol Clin North Am JT - The Urologic clinics of North America JID - 0423221 SB - IM MH - Early Detection of Cancer/*methods MH - Humans MH - Male MH - Mass Screening/*trends MH - Morbidity/trends MH - Practice Guidelines as Topic/*standards MH - Prostatic Neoplasms/*diagnosis/*epidemiology MH - United States/epidemiology OTO - NOTNLM OT - Guidelines OT - Prostate cancer OT - Prostate specific antigen (PSA) OT - Public health OT - Screening EDAT- 2014/04/15 06:00 MHDA- 2014/06/04 06:00 CRDT- 2014/04/15 06:00 PHST- 2014/04/15 06:00 [entrez] PHST- 2014/04/15 06:00 [pubmed] PHST- 2014/06/04 06:00 [medline] AID - S0094-0143(14)00006-8 [pii] AID - 10.1016/j.ucl.2014.01.005 [doi] PST - ppublish SO - Urol Clin North Am. 2014 May;41(2):229-35. doi: 10.1016/j.ucl.2014.01.005. PMID- 22837556 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20120814 LR - 20220408 IS - 1998-3611 (Electronic) IS - 0019-5154 (Print) IS - 0019-5154 (Linking) VI - 57 IP - 4 DP - 2012 Jul TI - Rational and ethical use of topical corticosteroids based on safety and efficacy. PG - 251-9 LID - 10.4103/0019-5154.97655 [doi] AB - Topical corticosteroids (TC) have greatly contributed to the dermatologist's ability to effectively treat several difficult dermatoses. The available range of formulations and potency gives flexibility to treat all groups of patients, different phases of disease, and different anatomic sites. However, the rapid rise in incidence of improper use of these drugs by dermatologists, general physicians, and patients threatens to bring disrepute to the entire group of these amazing drugs. Responsibility to disseminate proper knowledge regarding when, where, and how to use TC both to internists and patients rests primarily with the dermatologist. Benefits of rational and ethical use and the harm of overuse and misuse for nonmedical, specially for cosmetic purposes, should be clearly conveyed before penning a prescription involving TC. Simultaneous efforts to use political, legal, and other institutions to prevent misuse of these drugs by rationing their availability only through proper prescriptions will greatly help the cause. This will hopefully bring down both the extremes of ever increasing cases of steroid-induced dermatoses on one hand and the irrational fears of using TC in well justified indications on the other. FAU - Rathi, Sanjay K AU - Rathi SK AD - Consultant Dermatologist, Siliguri, West Bengal, India. drsrathi2@gmail.com FAU - D'Souza, Paschal AU - D'Souza P LA - eng PT - Journal Article PL - India TA - Indian J Dermatol JT - Indian journal of dermatology JID - 0370750 PMC - PMC3401837 OTO - NOTNLM OT - Abuse OT - adverse effects OT - ethical use OT - indications OT - misuse OT - rational use OT - steroid responsive dermatoses OT - topical corticosteroids COIS- Conflict of Interest: Nil. EDAT- 2012/07/28 06:00 MHDA- 2012/07/28 06:01 PMCR- 2012/07/01 CRDT- 2012/07/28 06:00 PHST- 2012/07/28 06:00 [entrez] PHST- 2012/07/28 06:00 [pubmed] PHST- 2012/07/28 06:01 [medline] PHST- 2012/07/01 00:00 [pmc-release] AID - IJD-57-251 [pii] AID - 10.4103/0019-5154.97655 [doi] PST - ppublish SO - Indian J Dermatol. 2012 Jul;57(4):251-9. doi: 10.4103/0019-5154.97655. PMID- 11413275 OWN - NLM STAT- MEDLINE DCOM- 20010726 LR - 20220331 IS - 0022-3050 (Print) IS - 1468-330X (Electronic) IS - 0022-3050 (Linking) VI - 71 IP - 1 DP - 2001 Jul TI - Biochemical alterations during medication withdrawal in Parkinson's disease with and without neuroleptic malignant-like syndrome. PG - 111-3 AB - The object was to assess alterations in CSF concentrations of monoamine metabolites during withdrawal of medication in patients with Parkinson's disease in relation to the presence or absence of episodes resembling neuroleptic malignant syndrome (NMS). This syndrome is a fatal condition developing after neuroleptic therapy, and a neuroleptic malignant-like syndrome (NMLS) may also occur after withdrawal of antiparkinsonian drugs in patients with Parkinson's disease. Previous biochemical assays showed that the CSF concentration of the dopamine metabolite homovanillic acid (HVA) is an independent prognostic factor for development of NMLS in patients with Parkinson's disease. In the present study, CSF concentrations of HVA, the noradrenaline (norepinephrine) metabolite 3-methoxy-4-hydroxyphenylethylene glycol, and the serotonin metabolite 5-hydroxyindole acetic acid were assayed using high performance liquid chromatography with electrochemical detection. The study population consisted of nine patients with Parkinson's disease with NMLS and 12 without NMLS, in whom metabolites were assayed during both withdrawal and remedicated periods. Concentrations of HVA in the CSF were significantly lower during the withdrawal period than the medicated period regardless of whether patients developed NMLS, and HVA concentrations were comparably increased after remedication in both groups. However, HVA concentrations were significantly lower in patients with NMLS than in those without NMLS during both withdrawal and medicated periods. Other metabolites showed no significant differences. The present data provide further biochemical evidence for extremely suppressed central dopaminergic activity during NMLS, which may indicate a narrow safety margin for medication withdrawal in patients with Parkinson's disease. FAU - Ueda, M AU - Ueda M AD - Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan. Ueda1222@aol.com FAU - Hamamoto, M AU - Hamamoto M FAU - Nagayama, H AU - Nagayama H FAU - Okubo, S AU - Okubo S FAU - Amemiya, S AU - Amemiya S FAU - Katayama, Y AU - Katayama Y LA - eng PT - Journal Article PL - England TA - J Neurol Neurosurg Psychiatry JT - Journal of neurology, neurosurgery, and psychiatry JID - 2985191R RN - X77S6GMS36 (Homovanillic Acid) SB - IM MH - Aged MH - Analysis of Variance MH - Female MH - Homovanillic Acid/*cerebrospinal fluid MH - Humans MH - Male MH - Neuroleptic Malignant Syndrome/*cerebrospinal fluid MH - Parkinson Disease/*cerebrospinal fluid MH - Substance Withdrawal Syndrome/*cerebrospinal fluid PMC - PMC1737455 EDAT- 2001/06/20 10:00 MHDA- 2001/07/28 10:01 PMCR- 2004/07/01 CRDT- 2001/06/20 10:00 PHST- 2001/06/20 10:00 [pubmed] PHST- 2001/07/28 10:01 [medline] PHST- 2001/06/20 10:00 [entrez] PHST- 2004/07/01 00:00 [pmc-release] AID - 10.1136/jnnp.71.1.111 [doi] PST - ppublish SO - J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):111-3. doi: 10.1136/jnnp.71.1.111. PMID- 35434566 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2589-0042 (Electronic) IS - 2589-0042 (Linking) VI - 25 IP - 4 DP - 2022 Apr 15 TI - Data-driven prediction of battery failure for electric vehicles. PG - 104172 LID - 10.1016/j.isci.2022.104172 [doi] LID - 104172 AB - Despite great progress in battery safety modeling, accurately predicting the evolution of multiphysics systems is extremely challenging. The question on how to ensure safety of billions of automotive batteries during their lifetime remains unanswered. In this study, we overcome the challenge by developing machine learning techniques based on the recorded data that are uploaded to the cloud. Using charging voltage and temperature curves from early cycles that are yet to exhibit symptoms of battery failure, we apply data-driven models to both predict and classify the sample data by health condition based on the observational, empirical, physical, and statistical understanding of the multiscale systems. The best well-integrated machine learning models achieve a verified classification accuracy of 96.3% (exhibiting an increase of 20.4% from initial model) and an average misclassification test error of 7.7%. Our findings highlight the need for cloud-based artificial intelligence technology tailored to robustly and accurately predict battery failure in real-world applications. CI - © 2022 The Author(s). FAU - Zhao, Jingyuan AU - Zhao J AD - BYD Automotive Engineering Research Institute, Shenzhen 518118, China. AD - Institute of Transportation Studies, University of California, Davis, CA 95616, USA. FAU - Ling, Heping AU - Ling H AD - BYD Automotive Engineering Research Institute, Shenzhen 518118, China. FAU - Wang, Junbin AU - Wang J AD - BYD Automotive Engineering Research Institute, Shenzhen 518118, China. FAU - Burke, Andrew F AU - Burke AF AD - Institute of Transportation Studies, University of California, Davis, CA 95616, USA. FAU - Lian, Yubo AU - Lian Y AD - BYD Automotive Engineering Research Institute, Shenzhen 518118, China. LA - eng PT - Journal Article DEP - 20220328 PL - United States TA - iScience JT - iScience JID - 101724038 PMC - PMC9010759 OTO - NOTNLM OT - Computational materials science OT - Electrochemical energy storage OT - Electrochemistry COIS- The authors declare no competing interests. EDAT- 2022/04/19 06:00 MHDA- 2022/04/19 06:01 PMCR- 2022/03/28 CRDT- 2022/04/18 06:42 PHST- 2021/10/25 00:00 [received] PHST- 2022/02/27 00:00 [revised] PHST- 2022/03/23 00:00 [accepted] PHST- 2022/04/18 06:42 [entrez] PHST- 2022/04/19 06:00 [pubmed] PHST- 2022/04/19 06:01 [medline] PHST- 2022/03/28 00:00 [pmc-release] AID - S2589-0042(22)00442-4 [pii] AID - 104172 [pii] AID - 10.1016/j.isci.2022.104172 [doi] PST - epublish SO - iScience. 2022 Mar 28;25(4):104172. doi: 10.1016/j.isci.2022.104172. eCollection 2022 Apr 15. PMID- 38460501 OWN - NLM STAT- MEDLINE DCOM- 20240415 LR - 20240415 IS - 1097-0274 (Electronic) IS - 0271-3586 (Linking) VI - 67 IP - 5 DP - 2024 May TI - "Breaking down in tears, soaked in sweat, and sick from the heat": Media-based composite narratives of first responders working during the 2021 Heat Dome. PG - 442-452 LID - 10.1002/ajim.23576 [doi] AB - BACKGROUND: During the summer of 2021, a deadly, unprecedented multiday Heat Dome engulfed western Canada. As a result of this extreme heat event (EHE), emergency dispatchers received an unparalleled increase in incoming 911 calls for ambulance, police, and fire (as first responders) services to attend to hundreds of heat-vulnerable community members succumbing to the heat. With 103 all-time heat records broken during this EHE and indoor temperatures of nearly 40°C, the first responders attending these calls faced extensive job demands and highly challenging operating conditions. Initial investigations have explored the health system-level impacts; however, little has been done to explore the impact on the first responders themselves. Therefore, this study aimed to improve our understanding of EHEs' impacts on the operational capabilities and health of first responders, specifically police, fire, ambulance, and dispatch services. METHODS: A systematized review and content analysis of media articles published on the 2021 Heat Dome in Canada was conducted (n = 2909), and four media-based composite narratives were developed highlighting police, fire, ambulance, and dispatch services. The Job Demands-Resources (JD-R) model was applied as a theoretical framework for occupational burnout. RESULTS: The media-based composite narratives highlighted that first responders faced record-breaking call volumes, increased mental-health-related claims, and exhaustive heat-related physiological stress. Using the JD-R model as a theoretical framework for occupational burnout, we identified three measures of stressful job demand: work overload (e.g., the surge in call volume, firefighters responding to medical emergencies), emotional demands (e.g., severe medical emergencies, sudden deaths, unresponsive patients, distraught family members), and physical demands (e.g., resuscitation in personal protective equipment, heat-related illness). CONCLUSION: The experiences described underscore the importance of supporting first responders during work in extreme heat conditions. These findings have important implications for addressing rising rates of burnout during and following public health crises, such as EHEs, a problem that is increasingly being recognized as a threat to the Canadian public healthcare system. CI - © 2024 The Authors. American Journal of Industrial Medicine published by Wiley Periodicals LLC. FAU - Tetzlaff, Emily J AU - Tetzlaff EJ AUID- ORCID: 0000-0002-4192-474X AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. AD - Heat Division, Climate Change and Innovation Bureau, Healthy Environments and Consumer Safety Branch, Safe Environments Directorate, Health Canada, Ottawa, Ontario, Canada. FAU - Cassan, Casey AU - Cassan C AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. FAU - Goulet, Nicholas AU - Goulet N AUID- ORCID: 0000-0003-1941-3174 AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. AD - Heat Division, Climate Change and Innovation Bureau, Healthy Environments and Consumer Safety Branch, Safe Environments Directorate, Health Canada, Ottawa, Ontario, Canada. FAU - Gorman, Melissa AU - Gorman M AUID- ORCID: 0009-0006-9045-4656 AD - Heat Division, Climate Change and Innovation Bureau, Healthy Environments and Consumer Safety Branch, Safe Environments Directorate, Health Canada, Ottawa, Ontario, Canada. FAU - Hogya, Brooks AU - Hogya B AD - BC Emergency Health Services, Provincial Health Services Authority, Vancouver, British Columbia, Canada. FAU - Kenny, Glen P AU - Kenny GP AUID- ORCID: 0000-0001-8683-6973 AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada. AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. LA - eng PT - Journal Article DEP - 20240309 PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 SB - IM MH - Humans MH - Sweat MH - Emergencies MH - Hot Temperature MH - *Burnout, Professional MH - Canada MH - *Emergency Responders OTO - NOTNLM OT - emergency medical services OT - extreme heat event OT - first responders OT - heat wave OT - public safety EDAT- 2024/03/10 00:42 MHDA- 2024/04/15 06:42 CRDT- 2024/03/09 18:24 PHST- 2024/01/15 00:00 [revised] PHST- 2023/06/30 00:00 [received] PHST- 2024/02/19 00:00 [accepted] PHST- 2024/04/15 06:42 [medline] PHST- 2024/03/10 00:42 [pubmed] PHST- 2024/03/09 18:24 [entrez] AID - 10.1002/ajim.23576 [doi] PST - ppublish SO - Am J Ind Med. 2024 May;67(5):442-452. doi: 10.1002/ajim.23576. Epub 2024 Mar 9. PMID- 35002178 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240824 IS - 0975-9476 (Print) IS - 0976-2809 (Electronic) IS - 0975-9476 (Linking) VI - 13 IP - 2 DP - 2022 Apr-Jun TI - AYUSH- 64: A potential therapeutic agent in COVID-19. PG - 100538 LID - S0975-9476(21)00227-8 [pii] LID - 10.1016/j.jaim.2021.100538 [doi] LID - 100538 AB - Corona Virus disease (COVID-19) has become a global pandemic resulting in large scale morbidity and mortality worldwide. The management of COVID-19 has been a big challenge because of multifactorial pathophysiology and no specific treatment. AYUSH-64, a poly-herbal formulation developed by CCRAS, Ministry of AYUSH, Govt. of India through extensive pharmacological, toxicological and clinical studies has proven its safety and efficacy in infective febrile conditions such as malaria and influenza. AYUSH- 64 has four ingredients having immunomodulatory, anti-inflammatory, antipyretic, antioxidant and anti-viral activities. It arrests the extreme inflammatory responses in COVID-19 that causes progression to significant morbidity. AYUSH-64 has also been incorporated in the National COVID management protocol based on Ayurveda and Yoga by Government of India for asymptomatic and mild cases of COVID-19. Further, on the basis of tangible evidence generated through robust clinical and experimental studies on AYUSH-64, the Ministry of AYUSH has launched nation-wide campaign for mass distribution of AYUSH-64 to asymptomatic, mild to moderate COVID-19 patients in home isolation to reduce the burden on the hospital. This review will highlight the specifications of AYUSH-64, its mechanism of action, its repurposing for COVID-19, various clinical and experimental studies. CI - © 2021 The Authors. FAU - Panda, Ashok Kumar AU - Panda AK AD - Central Ayurveda Research Institute, Bhubaneswar, Odisha, Central Council of Research in Ayurveda Sciences, Ministry of AYUSH, Govt. of India, India. Electronic address: akpanda_06@yahoo.co.in. FAU - Kar, Sarbeswar AU - Kar S AD - JSS Ayurveda Medical College &Hospital, Mysore, Karnataka, India. FAU - Rai, Amit Kumar AU - Rai AK AD - Central Council of Research in Ayurveda Sciences, Ministry of AYUSH, Govt. of India, India. FAU - Rao, B C S AU - Rao BCS AD - Central Council of Research in Ayurveda Sciences, Ministry of AYUSH, Govt. of India, India. FAU - Srikanth, N AU - Srikanth N AD - Central Council of Research in Ayurveda Sciences, Ministry of AYUSH, Govt. of India, India. LA - eng PT - Journal Article PT - Review DEP - 20220104 PL - United States TA - J Ayurveda Integr Med JT - Journal of Ayurveda and integrative medicine JID - 101551404 PMC - PMC8723836 OTO - NOTNLM OT - AYUSH-64 OT - Ayurveda OT - COVID-19 OT - Corona virus disease OT - Immunomodulation OT - SARS-CoV-2 EDAT- 2022/01/11 06:00 MHDA- 2022/01/11 06:01 PMCR- 2022/01/04 CRDT- 2022/01/10 09:01 PHST- 2021/07/09 00:00 [received] PHST- 2021/08/23 00:00 [revised] PHST- 2021/12/10 00:00 [accepted] PHST- 2022/01/11 06:00 [pubmed] PHST- 2022/01/11 06:01 [medline] PHST- 2022/01/10 09:01 [entrez] PHST- 2022/01/04 00:00 [pmc-release] AID - S0975-9476(21)00227-8 [pii] AID - 100538 [pii] AID - 10.1016/j.jaim.2021.100538 [doi] PST - ppublish SO - J Ayurveda Integr Med. 2022 Apr-Jun;13(2):100538. doi: 10.1016/j.jaim.2021.100538. Epub 2022 Jan 4. PMID- 37764098 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231003 IS - 2076-2607 (Print) IS - 2076-2607 (Electronic) IS - 2076-2607 (Linking) VI - 11 IP - 9 DP - 2023 Sep 8 TI - Probiotic Properties and Safety Evaluation of Lactobacillus plantarum HY7718 with Superior Storage Stability Isolated from Fermented Squid. LID - 10.3390/microorganisms11092254 [doi] LID - 2254 AB - The aim of this study was to identify new potential probiotics with improved storage stability and to evaluate their efficacy and safety. Sixty lactic acid bacteria strains were isolated from Korean traditional fermented foods, and their survival was tested under extreme conditions. Lactobacillus plantarum HY7718 (HY7718) showed the greatest stability during storage. HY7718 also showed a stable growth curve under industrial conditions. Whole genome sequencing revealed that the HY7718 genome comprises 3.26 Mbp, with 44.5% G + C content, and 3056 annotated Protein-coding DNA sequences (CDSs). HY7718 adhered to intestinal epithelial cells and was tolerant to gastric fluids. Additionally, HY7718 exhibited no hemolytic activity and was not resistant to antibiotics, confirming that it has probiotic properties and is safe for consumption. Additionally, we evaluated its effects on intestinal health using TNF-induced Caco-2 cells. HY7718 restored the expression of tight junction proteins such as zonular occludens (ZO-1, ZO-2), occludin (OCLN), and claudins (CLDN1, CLDN4), and regulated the expression of myosin light-chain kinase (MLCK), Elk-1, and nuclear factor kappa B subunit 1 (NFKB1). Moreover, HY7718 reduced the secretion of proinflammatory cytokines such as interleukin-6 (IL-6) and IL-8, as well as reducing the levels of peroxide-induced reactive oxygen species. In conclusion, HY7718 has probiotic properties, is safe, is stable under extreme storage conditions, and exerts positive effects on intestinal cells. These results suggest that L. plantarum HY7718 is a potential probiotic for use as a functional supplement in the food industry. FAU - Kim, Hyeonji AU - Kim H AUID- ORCID: 0000-0002-6923-6113 AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. FAU - Yoo, Myeong-Seok AU - Yoo MS AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. FAU - Jeon, Hyejin AU - Jeon H AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. FAU - Shim, Jae-Jung AU - Shim JJ AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. FAU - Park, Woo-Jung AU - Park WJ AD - Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea. FAU - Kim, Joo-Yun AU - Kim JY AUID- ORCID: 0000-0002-5534-2871 AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. FAU - Lee, Jung-Lyoul AU - Lee JL AD - R&BD Center, hy Co., Ltd., 22, Giheungdanji-ro 24beon-gil, Giheung-gu, Yongin-si 17086, Republic of Korea. LA - eng PT - Journal Article DEP - 20230908 PL - Switzerland TA - Microorganisms JT - Microorganisms JID - 101625893 PMC - PMC10534859 OTO - NOTNLM OT - Lactobacillus plantarum OT - fermented foods OT - probiotics OT - storage stability OT - tight junction COIS- The authors declare no conflict of interest. EDAT- 2023/09/28 06:43 MHDA- 2023/09/28 06:44 PMCR- 2023/09/08 CRDT- 2023/09/28 01:30 PHST- 2023/08/21 00:00 [received] PHST- 2023/09/04 00:00 [revised] PHST- 2023/09/06 00:00 [accepted] PHST- 2023/09/28 06:44 [medline] PHST- 2023/09/28 06:43 [pubmed] PHST- 2023/09/28 01:30 [entrez] PHST- 2023/09/08 00:00 [pmc-release] AID - microorganisms11092254 [pii] AID - microorganisms-11-02254 [pii] AID - 10.3390/microorganisms11092254 [doi] PST - epublish SO - Microorganisms. 2023 Sep 8;11(9):2254. doi: 10.3390/microorganisms11092254. PMID- 18335652 OWN - NLM STAT- MEDLINE DCOM- 20080530 LR - 20131121 IS - 1545-9616 (Print) IS - 1545-9616 (Linking) VI - 7 IP - 2 DP - 2008 Feb TI - Treatment of hyperkeratosis with Kerafoam emollient foam (30% urea) to assess effectiveness and safety within a clinical setting: a case study report. PG - 159-62 AB - Ten patients enrolled in a single center, observational, prospective, open-label case study to assess the effectiveness and safety of a 28 day regimen with Kerafoam 30% urea emollient foam for treatment of hyperkeratosis. Clinician assessments of skin condition were recorded at baseline, day 14, and day 28. In addition, patients' ratings of the treatment impact on quality of life and skin condition, as well as overall satisfaction with the product were obtained. Key results demonstrated significant improvements in clinicians' ratings of skin condition at the day 14 and day 28 visits compared to baseline and significant improvements in patients' ratings of quality of life. No adverse events were reported and all patients completed the 28-day treatment regimen. Patient and clinician evaluations of the 30% urea emollient foam product were extremely favorable. FAU - Goldstein, Jay A AU - Goldstein JA AD - jaygoldsteinmd@aol.com FAU - Gurge, Ronald M AU - Gurge RM LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Drugs Dermatol JT - Journal of drugs in dermatology : JDD JID - 101160020 RN - 0 (Emollients) RN - 8W8T17847W (Urea) SB - IM MH - Administration, Cutaneous MH - Adult MH - Aged MH - Aged, 80 and over MH - Dose-Response Relationship, Drug MH - Drug Administration Schedule MH - Emollients/administration & dosage/chemistry/*therapeutic use MH - Female MH - Humans MH - Hyperkeratosis, Epidermolytic/*drug therapy/pathology MH - Male MH - Middle Aged MH - Patient Satisfaction/statistics & numerical data MH - Prospective Studies MH - Quality of Life MH - Severity of Illness Index MH - Skin/*drug effects/pathology MH - Time Factors MH - Treatment Outcome MH - Urea/administration & dosage/chemistry/*therapeutic use EDAT- 2008/03/14 09:00 MHDA- 2008/05/31 09:00 CRDT- 2008/03/14 09:00 PHST- 2008/03/14 09:00 [pubmed] PHST- 2008/05/31 09:00 [medline] PHST- 2008/03/14 09:00 [entrez] PST - ppublish SO - J Drugs Dermatol. 2008 Feb;7(2):159-62. PMID- 33670459 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210316 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 11 IP - 2 DP - 2021 Feb 18 TI - Amelioration of Pet Overpopulation and Abandonment Using Control of Breeding and Sale, and Compulsory Owner Liability Insurance. LID - 10.3390/ani11020524 [doi] LID - 524 AB - Overpopulation and abandonment of pets are long-standing and burgeoning concerns that involve uncontrolled breeding and selling, illegal trafficking, overpopulation, and pet safety and well-being issues. Abandonment of pets creates numerous negative externalities and multimillion-dollar costs, in addition to severe consequences and problems concerning animal welfare (e.g., starvation, untreated disease, climatic extremes, uncertainty of rescue and adoption), ecological (e.g., invasive species and introduction of novel pathogens), public health and safety (e.g., risks to people from bites, zoonoses, or road hazards), and economic (e.g., financial burdens for governmental and nongovernmental organizations). These interwoven problems persist for several reasons, including the following: (1) lack of an efficient system for the prevention of abandonment and overpopulation, (2) lack of regulatory liability for pet owners, (3) lack of legal alternative to abandonment. This article proposes a novel comprehensive management system for amelioration of overpopulation and abandonment of pets aimed to tackle the current supply and demand dysfunction of the pet market and provide a legal alternative to abandonment. FAU - Bernete Perdomo, Eva AU - Bernete Perdomo E AUID- ORCID: 0000-0003-4540-0289 AD - University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain. FAU - Araña Padilla, Jorge E AU - Araña Padilla JE AD - University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain. FAU - Dewitte, Siegfried AU - Dewitte S AUID- ORCID: 0000-0001-6010-4782 AD - Katholieke Universiteit Leuven, 3000 Leuven, Belgium. LA - eng PT - Journal Article DEP - 20210218 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC7922531 OTO - NOTNLM OT - exotic pets OT - pet abandonment OT - pet market regulation OT - pet overpopulation OT - pet welfare COIS- The authors declare no conflict of interest. EDAT- 2021/03/07 06:00 MHDA- 2021/03/07 06:01 PMCR- 2021/02/18 CRDT- 2021/03/06 01:07 PHST- 2020/09/30 00:00 [received] PHST- 2021/02/09 00:00 [revised] PHST- 2021/02/15 00:00 [accepted] PHST- 2021/03/06 01:07 [entrez] PHST- 2021/03/07 06:00 [pubmed] PHST- 2021/03/07 06:01 [medline] PHST- 2021/02/18 00:00 [pmc-release] AID - ani11020524 [pii] AID - animals-11-00524 [pii] AID - 10.3390/ani11020524 [doi] PST - epublish SO - Animals (Basel). 2021 Feb 18;11(2):524. doi: 10.3390/ani11020524. PMID- 36651200 OWN - NLM STAT- MEDLINE DCOM- 20230406 LR - 20230814 IS - 1365-2346 (Electronic) IS - 0265-0215 (Linking) VI - 40 IP - 5 DP - 2023 May 1 TI - The burden of peri-operative work at night as perceived by anaesthesiologists: An international survey. PG - 326-333 LID - 10.1097/EJA.0000000000001791 [doi] AB - BACKGROUND: No international data are available on the night working conditions and workload of anaesthesiologists and their opinions about associated risks. OBJECTIVE: The aim of this international survey was to describe the peri-operative night working conditions of anaesthesiologists and their perception of the impact these conditions have on patient outcomes and their own quality of life. DESIGN: Cross-sectional survey. SETTING: Not applicable. PARTICIPANTS: Anaesthesiologists providing peri-operative care during night shifts responded to an online survey promoted by the European Society of Anaesthesiology and Intensive Care (ESAIC). INTERVENTIONS: None. MAIN OUTCOME MEASURE: Twenty-eight closed questions. RESULTS: Overall 5292 complete responses were analysed. Of these, 920 were from trainees. The median reported monthly number of night shifts was 4 [IQR 3-6]. An irregular weekly night shift schedule was most common (51%). Almost all the respondents (98%) declared that their centres have no relevant institutional programmes to monitor stress or fatigue. Most respondents (90%) had received no training or information regarding performance improvement methods for night work. Most respondents were of the opinion that sleep deprivation affects their professional performance (71%) and that their fatigue during night work may increase the peri-operative risk for their patients (74%). Furthermore, 81% of the respondents agreed or strongly agreed that night work represents an additional risk per se for patient safety, and 77% stated that their night work affects the quality of their daily life significantly or extremely. CONCLUSION: Anaesthesiologists commonly perform perioperative night work without appropriate training, education or support on this specific condition. They perceive current practice as adversely affecting their professional performance and the safety of their patients. They also report significant effects on their own quality of life. Adequate training and education for night work may ally some of these concerns and programmes to monitor workers' stress and fatigue should be mandated to assess whether these concerns are justified. TRIAL REGISTRATION: Not applicable. CI - Copyright © 2023 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited. FAU - Cortegiani, Andrea AU - Cortegiani A AD - From the Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), University of Palermo (AC, MI, AG), Department of Anaesthesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, Palermo, Italy (AC, MI, AG), Department of Anesthesiology and Intensive Care Unit, Aix Marseille University, Assistance Publique Hôpitaux Universitaires de Marseille, Nord Hospital, Marseille, France (IL), Department of Paediatric and Obstetric Anaesthesia, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark (AA), Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany (PK), Consorcio Hospital General Universitario de Valencia, Avenida Tres Cruces, Valencia. Methodology Research Department, Universidad Europea de Valencia, Spain (CSRG), Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India (SNM), Department of Intensive Care, Amsterdam University Medical Centers, Location 'AMC', AZ, Amsterdam, the Netherlands (MJS), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (MJS), Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford, UK (MJS), Department of Anaesthesiology, Critical Care and Pain Medicine, Policlinico Umberto I Teaching Hospital, Sapienza University of Rome, Rome (FB), Section of Anesthesia, Analgesia and Intensive Care, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia (EdeR), Division of Anesthesia and Intensive Care, Department of Human Pathology of the Adult and Evolutive Age 'Gaetano Barresi', University of Messina, Policlinico 'G. Martino', Messina, Italy (AN) and General Intensive Care Unit of the Shaare Zedek Medical Centre and the Hebrew University Faculty of Medicine, Jerusalem, Israel (SE). FAU - Ippolito, Mariachiara AU - Ippolito M FAU - Lakbar, Ines AU - Lakbar I FAU - Afshari, Arash AU - Afshari A FAU - Kranke, Peter AU - Kranke P FAU - Garcia, Carolina Soledad Romero AU - Garcia CSR FAU - Myatra, Sheila Nainan AU - Myatra SN FAU - Schultz, Marcus J AU - Schultz MJ FAU - Giarratano, Antonino AU - Giarratano A FAU - Bilotta, Federico AU - Bilotta F FAU - De Robertis, Edoardo AU - De Robertis E FAU - Noto, Alberto AU - Noto A FAU - Einav, Sharon AU - Einav S LA - eng PT - Journal Article DEP - 20230118 PL - England TA - Eur J Anaesthesiol JT - European journal of anaesthesiology JID - 8411711 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Quality of Life MH - Surveys and Questionnaires MH - *Anesthesiologists MH - Fatigue EDAT- 2023/01/19 06:00 MHDA- 2023/04/06 06:41 CRDT- 2023/01/18 04:33 PHST- 2023/04/06 06:41 [medline] PHST- 2023/01/19 06:00 [pubmed] PHST- 2023/01/18 04:33 [entrez] AID - 00003643-202305000-00004 [pii] AID - 10.1097/EJA.0000000000001791 [doi] PST - ppublish SO - Eur J Anaesthesiol. 2023 May 1;40(5):326-333. doi: 10.1097/EJA.0000000000001791. Epub 2023 Jan 18. PMID- 21656276 OWN - NLM STAT- MEDLINE DCOM- 20111102 LR - 20211020 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 41 IP - 7 DP - 2011 Jul TI - Paediatric radiology seen from Africa. Part I: providing diagnostic imaging to a young population. PG - 811-25 LID - 10.1007/s00247-011-2081-8 [doi] AB - Paediatric radiology requires dedicated equipment, specific precautions related to ionising radiation, and specialist knowledge. Developing countries face difficulties in providing adequate imaging services for children. In many African countries, children represent an increasing proportion of the population, and additional challenges follow from extreme living conditions, poverty, lack of parental care, and exposure to tuberculosis, HIV, pneumonia, diarrhoea and violent trauma. Imaging plays a critical role in the treatment of these children, but is expensive and difficult to provide. The World Health Organisation initiatives, of which the World Health Imaging System for Radiography (WHIS-RAD) unit is one result, needs to expand into other areas such as the provision of maintenance servicing. New initiatives by groups such as Rotary and the World Health Imaging Alliance to install WHIS-RAD units in developing countries and provide digital solutions, need support. Paediatric radiologists are needed to offer their services for reporting, consultation and quality assurance for free by way of teleradiology. Societies for paediatric radiology are needed to focus on providing a volunteer teleradiology reporting group, information on child safety for basic imaging, guidelines for investigations specific to the disease spectrum, and solutions for optimising imaging in children. FAU - Andronikou, Savvas AU - Andronikou S AD - Radiology Department, University of Witwatersrand, York Rd Parktown, Johannesburg Gauteng, 2193, South Africa. docsav@mweb.co.za FAU - McHugh, Kieran AU - McHugh K FAU - Abdurahman, Nuraan AU - Abdurahman N FAU - Khoury, Bryan AU - Khoury B FAU - Mngomezulu, Victor AU - Mngomezulu V FAU - Brant, William E AU - Brant WE FAU - Cowan, Ian AU - Cowan I FAU - McCulloch, Mignon AU - McCulloch M FAU - Ford, Nathan AU - Ford N LA - eng PT - Journal Article PT - Review DEP - 20110609 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Africa/epidemiology MH - Developing Countries MH - Health Resources MH - Health Services Accessibility MH - Humans MH - *International Cooperation MH - *Pediatrics MH - Poverty MH - Radiation Protection MH - Radiographic Image Interpretation, Computer-Assisted MH - Radiology/*methods MH - Teleradiology MH - World Health Organization EDAT- 2011/06/10 06:00 MHDA- 2011/11/04 06:00 CRDT- 2011/06/10 06:00 PHST- 2010/10/09 00:00 [received] PHST- 2011/03/14 00:00 [accepted] PHST- 2010/12/30 00:00 [revised] PHST- 2011/06/10 06:00 [entrez] PHST- 2011/06/10 06:00 [pubmed] PHST- 2011/11/04 06:00 [medline] AID - 10.1007/s00247-011-2081-8 [doi] PST - ppublish SO - Pediatr Radiol. 2011 Jul;41(7):811-25. doi: 10.1007/s00247-011-2081-8. Epub 2011 Jun 9. PMID- 38237330 OWN - NLM STAT- MEDLINE DCOM- 20240205 LR - 20240209 IS - 1095-8630 (Electronic) IS - 0301-4797 (Linking) VI - 352 DP - 2024 Feb 14 TI - Potential applications of extremophilic bacteria in the bioremediation of extreme environments contaminated with heavy metals. PG - 120081 LID - S0301-4797(24)00067-7 [pii] LID - 10.1016/j.jenvman.2024.120081 [doi] AB - Protecting the environment from harmful pollutants has become increasingly difficult in recent decades. The presence of heavy metal (HM) pollution poses a serious environmental hazard that requires intricate attention on a worldwide scale. Even at low concentrations, HMs have the potential to induce deleterious health effects in both humans and other living organisms. Therefore, various strategies have been proposed to address this issue, with extremophiles being a promising solution. Bacteria that exhibit resistance to metals are preferred for applications involving metal removal due to their capacity for rapid multiplication and growth. Extremophiles are a special group of microorganisms that are capable of surviving under extreme conditions such as extreme temperatures, pH levels, and high salt concentrations where other organisms cannot. Due to their unique enzymes and adaptive capabilities, extremophiles are well suited as catalysts for environmental biotechnology applications, including the bioremediation of HMs through various strategies. The mechanisms of resistance to HMs by extremophilic bacteria encompass: (i) metal exclusion by permeability barrier; (ii) extracellular metal sequestration by protein/chelator binding; (iii) intracellular sequestration of the metal by protein/chelator binding; (iv) enzymatic detoxification of a metal to a less toxic form; (v) active transport of HMs; (vi) passive tolerance; (vii) reduced metal sensitivity of cellular targets to metal ions; and (viii) morphological change of cells. This review provides comprehensive information on extremophilic bacteria and their potential roles for bioremediation, particularly in environments contaminated with HMs, which pose a threat due to their stability and persistence. Genetic engineering of extremophilic bacteria in stressed environments could help in the bioremediation of contaminated sites. Due to their unique characteristics, these organisms and their enzymes are expected to bridge the gap between biological and chemical industrial processes. However, the structure and biochemical properties of extremophilic bacteria, along with any possible long-term effects of their applications, need to be investigated further. CI - Copyright © 2024 Elsevier Ltd. All rights reserved. FAU - Sun, Jianzhong AU - Sun J AD - Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. Electronic address: jzsun1002@ujs.edu.cn. FAU - He, Xing AU - He X AD - Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. FAU - LE, Yilin AU - LE Y AD - Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. Electronic address: leyilin@ujs.edu.cn. FAU - Al-Tohamy, Rania AU - Al-Tohamy R AD - Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. FAU - Ali, Sameh S AU - Ali SS AD - Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China; Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. Electronic address: samh@ujs.edu.cn. LA - eng PT - Journal Article PT - Review DEP - 20240118 PL - England TA - J Environ Manage JT - Journal of environmental management JID - 0401664 RN - 0 (Metals, Heavy) RN - 0 (Chelating Agents) SB - IM MH - Humans MH - Biodegradation, Environmental MH - *Extremophiles/metabolism MH - *Metals, Heavy/toxicity MH - Bacteria/genetics MH - Extreme Environments MH - Chelating Agents OTO - NOTNLM OT - Bacteria OT - Extremophiles OT - Hazardous pollutants OT - Heavy metal removal OT - Tolerance mechanisms OT - Toxicity COIS- Declaration of competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/01/19 00:42 MHDA- 2024/02/05 06:42 CRDT- 2024/01/18 18:07 PHST- 2023/11/25 00:00 [received] PHST- 2023/12/31 00:00 [revised] PHST- 2024/01/07 00:00 [accepted] PHST- 2024/02/05 06:42 [medline] PHST- 2024/01/19 00:42 [pubmed] PHST- 2024/01/18 18:07 [entrez] AID - S0301-4797(24)00067-7 [pii] AID - 10.1016/j.jenvman.2024.120081 [doi] PST - ppublish SO - J Environ Manage. 2024 Feb 14;352:120081. doi: 10.1016/j.jenvman.2024.120081. Epub 2024 Jan 18. PMID- 33371618 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201229 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 16 IP - 5 DP - 2017 Sep TI - Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate. PG - 868-880 LID - 10.1111/1541-4337.12284 [doi] AB - Sodium benzoate and potassium sorbate are extremely useful agents for food and beverage preservation, yet concerns remain over their complete safety. Benzoate can react with the ascorbic acid in drinks to produce the carcinogen benzene. A few children develop allergy to this additive while, as a competitive inhibitor of D-amino acid oxidase, benzoate can also influence neurotransmission and cognitive functioning. Model organism and cell culture studies have raised some issues. Benzoate has been found to exert teratogenic and neurotoxic effects on zebrafish embryos. In addition, benzoate and sorbate are reported to cause chromosome aberrations in cultured human lymphocytes; also to be potently mutagenic toward the mitochondrial DNA in aerobic yeast cells. Whether the substantial human consumption of these compounds could significantly increase levels of such damages in man is still unclear. There is no firm evidence that it is a risk factor in type 2 diabetes. The clinical administration of sodium benzoate is of proven benefit for many patients with urea cycle disorders, while recent studies indicate it may also be advantageous in the treatment of multiple sclerosis, schizophrenia, early-stage Alzheimer's disease and Parkinson's disease. Nevertheless, exposure to high amounts of this agent should be approached with caution, especially since it has the potential to generate a shortage of glycine which, in turn, can negatively influence brain neurochemistry. We discuss here how a small fraction of the population might be rendered-either through their genes or a chronic medical condition-particularly susceptible to any adverse effects of sodium benzoate. CI - © 2017 Institute of Food Technologists®. FAU - Piper, Joseph D AU - Piper JD AUID- ORCID: 0000-0003-4019-2329 AD - Centre for Genomics and Child Health, Blizard Inst., Queen Mary Univ. of London, London, E1 2AT, United Kingdom. FAU - Piper, Peter W AU - Piper PW AD - Dept. of Molecular Biology and Biotechnology, Univ. of Sheffield, Sheffield, S10 2TN, United Kingdom. LA - eng GR - National Inst. for Health Research/ PT - Journal Article DEP - 20170714 PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 SB - IM OTO - NOTNLM OT - DNA damage OT - food preservatives OT - potassium sorbate OT - sodium benzoate OT - urea cycle disorder therapy EDAT- 2017/09/01 00:00 MHDA- 2017/09/01 00:01 CRDT- 2020/12/29 01:05 PHST- 2017/03/16 00:00 [received] PHST- 2017/06/08 00:00 [revised] PHST- 2017/06/10 00:00 [accepted] PHST- 2020/12/29 01:05 [entrez] PHST- 2017/09/01 00:00 [pubmed] PHST- 2017/09/01 00:01 [medline] AID - 10.1111/1541-4337.12284 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2017 Sep;16(5):868-880. doi: 10.1111/1541-4337.12284. Epub 2017 Jul 14. PMID- 35778007 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220706 IS - 1089-7623 (Electronic) IS - 0034-6748 (Linking) VI - 93 IP - 6 DP - 2022 Jun 1 TI - Characterization of a new ultra-high pressure shock tube facility for combustion and propulsion studies. PG - 063905 LID - 10.1063/5.0084047 [doi] AB - A new shock tube facility has been designed, constructed, and characterized at the University of Central Florida. This facility is capable of withstanding pressures of up to 1000 atm, allowing for combustion diagnostics of extreme conditions, such as in rocket combustion chambers or in novel power conversion cycles. For studies with toxic gas impurities, the high initial pressures required the development of a gas delivery system to ensure the longevity of the facility and the safety of the personnel. Data acquisition and experimental propagation were implemented with remote access to ensure safety, paired with a LabVIEW- and Python-based user interface. Thus far, test pressures of 270 atm, blast pressures of 730 atm, and temperatures approaching 10 000 K have been achieved. The extreme limitations of this facility allow for emission spectroscopy to be performed during the oxidation of fuel mixtures, e.g., alkanes diluted in argon and carbon dioxide. Ignition delay times were determined and compared to simulations using chemical kinetic mechanisms. The design, experimental procedures, processes of analysis, and uncertainty determination are outlined, and typical pressure profiles are compared with a new gas dynamics solver and empirical correlations developed across multiple shock tube facilities. Preliminary reactive mixture analyses are included with further investigation of the mixtures outlined. FAU - Urso, Justin J AU - Urso JJ AUID- ORCID: 0000-0003-1005-7265 AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Kinney, Cory AU - Kinney C AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Terracciano, Anthony C AU - Terracciano AC AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Barak, Samuel AU - Barak S AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Laich, Andrew AU - Laich A AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Albright, Marley A AU - Albright MA AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Pierro, Michael AU - Pierro M AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - McGaunn, Jonathan AU - McGaunn J AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. FAU - Vasu, Subith S AU - Vasu SS AUID- ORCID: 0000-0002-4164-3163 AD - Center for Advanced Turbomachinery and Energy Research (CATER), University of Central Florida, 4000 Central Florida Blvd., 40-307, Orlando, Florida 32816-2450, USA. LA - eng PT - Journal Article PL - United States TA - Rev Sci Instrum JT - The Review of scientific instruments JID - 0405571 SB - IM EDAT- 2022/07/02 06:00 MHDA- 2022/07/02 06:01 CRDT- 2022/07/01 22:03 PHST- 2022/07/01 22:03 [entrez] PHST- 2022/07/02 06:00 [pubmed] PHST- 2022/07/02 06:01 [medline] AID - 10.1063/5.0084047 [doi] PST - ppublish SO - Rev Sci Instrum. 2022 Jun 1;93(6):063905. doi: 10.1063/5.0084047. PMID- 29461615 OWN - NLM STAT- MEDLINE DCOM- 20191105 LR - 20191105 IS - 2284-0729 (Electronic) IS - 1128-3602 (Linking) VI - 22 IP - 3 DP - 2018 Feb TI - Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients. PG - 820-828 LID - 14318 [pii] LID - 10.26355/eurrev_201802_14318 [doi] AB - OBJECTIVE: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Here we analyzed the effect of 7 days treatment with 20 mg bilastine in patients with allergic rhinitis and/or chronic urticaria, on psychophysical performance assessed by the Formula One (F1) high-speed simulator-driving test. PATIENTS AND METHODS: This study is a phase IV, interventional, prospective, mono-centric, single arm, open-label trial. Eighteen outpatients affected by allergic rhinitis and/or chronic urticaria, able to perform a preliminary driving test on F1 simulator were considered (V-1). First, the patients had a screening visit to assess their eligibility (V0). Visit 1 (V1), at the end of placebo before bilastine treatment and Visit 2 (V2), at the end of bilastine treatment. The primary variable parameter was the ability to maintain the vehicle in a central position at different speeds (50, 150, and 250 km/h). RESULTS: Bilastine had a good safety profile and was well tolerated in terms of adverse events, laboratory parameters and vital signs. Bilastine did not have any negative effect on the ability to maintain the requested path, a constant speed as well as on attention and reactivity levels, even in extreme driving conditions. CONCLUSIONS: This study is the first done in patients with allergic rhinitis and/or chronic urticaria using a F1-high speed simulator-driving test evaluating subjects' performance under bilastine treatment. FAU - Demonte, A AU - Demonte A AD - Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine; Dermatology Unit; University of Modena and Reggio Emilia, Modena, Italy. patrizia.pepe@unimore.it. FAU - Guanti, M B AU - Guanti MB FAU - Liberati, S AU - Liberati S FAU - Biffi, A AU - Biffi A FAU - Fernando, F AU - Fernando F FAU - Fainello, M AU - Fainello M FAU - Pepe, P AU - Pepe P LA - eng PT - Clinical Trial, Phase IV PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Italy TA - Eur Rev Med Pharmacol Sci JT - European review for medical and pharmacological sciences JID - 9717360 RN - 0 (Benzimidazoles) RN - 0 (Histamine Antagonists) RN - 0 (Histamine H1 Antagonists, Non-Sedating) RN - 0 (Piperidines) RN - PA1123N395 (bilastine) SB - IM MH - Adult MH - Attention/drug effects/physiology MH - *Automobile Driving/psychology MH - Benzimidazoles/adverse effects/*therapeutic use MH - Chronic Disease MH - *Computer Simulation MH - Dizziness/chemically induced MH - Female MH - Histamine Antagonists/adverse effects/therapeutic use MH - Histamine H1 Antagonists, Non-Sedating/adverse effects/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Piperidines/adverse effects/*therapeutic use MH - Prospective Studies MH - Rhinitis, Allergic/*drug therapy/psychology MH - Urticaria/*drug therapy/psychology MH - Young Adult EDAT- 2018/02/21 06:00 MHDA- 2019/11/07 06:00 CRDT- 2018/02/21 06:00 PHST- 2018/02/21 06:00 [entrez] PHST- 2018/02/21 06:00 [pubmed] PHST- 2019/11/07 06:00 [medline] AID - 14318 [pii] AID - 10.26355/eurrev_201802_14318 [doi] PST - ppublish SO - Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):820-828. doi: 10.26355/eurrev_201802_14318. PMID- 32025911 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2363-9024 (Electronic) IS - 2363-9024 (Linking) VI - 4 IP - 1 DP - 2018 Oct 3 TI - Anesthetic management of a patient with congenital insensitivity to pain with anhidrosis by coadministration of remifentanil. PG - 72 LID - 10.1186/s40981-018-0208-8 [doi] LID - 72 AB - BACKGROUND: Congenital insensitivity to pain with anhidrosis (CIPA) is a rare autosomal recessive disease characterized by unexplained fever, systemic insensitivity to pain, anhidrosis, and mental distress. Anesthetic management is challenging because autonomic dysfunction can induce perioperative complications. Only a few reports of anesthetic management of CIPA patients have been published. We herein present a case of successful management of the same patient on two occasions using small doses of fentanyl and remifentanil. CASE PRESENTATION: A 37-year-old man with CIPA underwent two orthopedic operations. We were able to balance the dose of remifentanil to avoid the extremes of hyperalgesia when the dose is too low and shivering when the dose is too high. CONCLUSION: To our knowledge, no reports have described the anesthetic management of CIPA patients with remifentanil. We consider anesthetic management with coadministration of remifentanil to be potentially useful for such patients. FAU - Takeuchi, Yoko AU - Takeuchi Y AUID- ORCID: 0000-0002-5362-5384 AD - Department of Anesthesiology, Aichi Medical University School of Medicine, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. take.yoko.naname@gmail.com. FAU - Fujita, Yoshihito AU - Fujita Y AD - Department of Anesthesiology, Aichi Medical University School of Medicine, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. FAU - Shimomura, Takeshi AU - Shimomura T AD - Department of Anesthesiology, Aichi Medical University School of Medicine, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. FAU - Kurokawa, Shuji AU - Kurokawa S AD - Department of Anesthesiology, JA Aichikoseiren Konan Kosei Hospital, 137 Oomatubara Takaya, Konan, Aichi, Japan. FAU - Noguchi, Hiroki AU - Noguchi H AD - Department of Anesthesiology, JA Aichikoseiren Konan Kosei Hospital, 137 Oomatubara Takaya, Konan, Aichi, Japan. FAU - Fujiwara, Yoshihiro AU - Fujiwara Y AD - Department of Anesthesiology, Aichi Medical University School of Medicine, 1-1 Yazako Karimata, Nagakute, Aichi, 480-1195, Japan. LA - eng PT - Journal Article DEP - 20181003 PL - Germany TA - JA Clin Rep JT - JA clinical reports JID - 101682121 PMC - PMC6967053 OTO - NOTNLM OT - Anhidrosis OT - Congenital insensitivity to pain with anhidrosis OT - Insensitivity OT - Remifentanil OT - Safety COIS- The authors declare that they have no competing interests. EDAT- 2018/10/03 00:00 MHDA- 2018/10/03 00:01 PMCR- 2018/10/03 CRDT- 2020/02/07 06:00 PHST- 2018/08/17 00:00 [received] PHST- 2018/09/24 00:00 [accepted] PHST- 2020/02/07 06:00 [entrez] PHST- 2018/10/03 00:00 [pubmed] PHST- 2018/10/03 00:01 [medline] PHST- 2018/10/03 00:00 [pmc-release] AID - 10.1186/s40981-018-0208-8 [pii] AID - 208 [pii] AID - 10.1186/s40981-018-0208-8 [doi] PST - epublish SO - JA Clin Rep. 2018 Oct 3;4(1):72. doi: 10.1186/s40981-018-0208-8. PMID- 30287071 OWN - NLM STAT- MEDLINE DCOM- 20190104 LR - 20190104 IS - 1473-0502 (Print) IS - 1473-0502 (Linking) VI - 57 IP - 5 DP - 2018 Oct TI - Risks of leukapheresis and how to manage them-A non-systematic review. PG - 628-634 LID - S1473-0502(18)30359-8 [pii] LID - 10.1016/j.transci.2018.09.008 [doi] AB - Leukapheresis is like any other preparative apheresis, except it isn't: Leukapheresis typically takes much longer, larger blood volumes are processed and, consequently, larger ACD-A volumes are administered. Blood component donors and leukapheresis subjects are also quite different populations. Allogeneic donors tend to be younger and many are first-time donors, both of which are risk factors for adverse reactions during blood donation. Moreover, more than half of all leukapheresis collections are performed in patients. Here it is the age distribution, including patients at the extremes of age, as well as the underlying disease and co-morbidities which may expose them to higher, or different, risks compared to donors. Both groups thus have good reasons why adverse effects to leukapheresis might be more frequent, more severe, or even different in nature altogether. Compared to other preparative apheresis types like platelet or plasma apheresis, the risks of leukapheresis have been studied less extensively, as it is in comparison a relatively low-frequency intervention. Often leukapheresis remains a domain of hematologists who have a different sense of procedural safety than transfusionists. Furthermore, G-CSF mobilized "stem cell" aphereses by a wide margin outnumber unmobilized aphereses, so that the very strong signal from adverse reactions to G-CSF all but drowns out signals from the apheresis proper. This focused review assesses observations from leukapheresis as well as extrapolation of observations from other forms of preparative apheresis in an attempt to gauge the safety of leukapheresis and identify potential approaches to its further improvement. In short, the overall impression is one of a very satisfactory safety record of leukapheresis, with occasional issues with venous access or vasovagal problems, and frequent, but highly responsive and rarely limiting ACD-A toxicity. CI - Copyright © 2018 Elsevier Ltd. All rights reserved. FAU - Stenzinger, Miriam AU - Stenzinger M AD - Institute for Clinical Transfusion Medicine and Cell Therapy, Heidelberg, Germany; Institute for Immunology, University Hospital Heidelberg, Germany. FAU - Bonig, Halvard AU - Bonig H AD - Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt a. M., Germany; German Red Cross Blood Service Baden-Württemberg-Hessen, Institute Frankfurt a. M., Germany. Electronic address: h.boenig@blutspende.de. LA - eng PT - Journal Article PT - Review DEP - 20180915 PL - England TA - Transfus Apher Sci JT - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis JID - 101095653 MH - Blood Component Removal/*methods MH - Blood Donors MH - Humans MH - Leukapheresis/*methods MH - Risk Factors OTO - NOTNLM OT - Apheresis risks OT - Apheresis safety OT - Blood donor OT - Component donor OT - Leukapheresis EDAT- 2018/10/06 06:00 MHDA- 2019/01/05 06:00 CRDT- 2018/10/06 06:00 PHST- 2018/10/06 06:00 [pubmed] PHST- 2019/01/05 06:00 [medline] PHST- 2018/10/06 06:00 [entrez] AID - S1473-0502(18)30359-8 [pii] AID - 10.1016/j.transci.2018.09.008 [doi] PST - ppublish SO - Transfus Apher Sci. 2018 Oct;57(5):628-634. doi: 10.1016/j.transci.2018.09.008. Epub 2018 Sep 15. PMID- 38957898 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240717 IS - 1463-9084 (Electronic) IS - 1463-9076 (Linking) VI - 26 IP - 28 DP - 2024 Jul 17 TI - Theoretical study of the structural and thermodynamic properties of U-He compounds under high pressure. PG - 19228-19235 LID - 10.1039/d4cp02037e [doi] AB - Uranium is considered as a very important nuclear energy material because of the huge amount of energy it releases. As the main product of the spontaneous decay of uranium, it is difficult for helium to react with uranium because of its chemical inertness. Therefore, bubbles will be formed inside uranium, which could greatly reduce the performance of uranium or cause safety problems. Additionally, nuclear materials are usually operated in an environment of high-temperature and high-pressure, so it is necessary to figure out the exact state of helium inside uranium under extreme conditions. Here, we explored the structural stability of the U-He system under high pressure and high temperature by using density functional theory calculations. Two metastable phases are found between 50 and 400 GPa: U(4)He with space group Fmmm and U(6)He with space group P1̄. Both are metallic and adopt layered structures. Electron localization function calculation combined with charge density difference analysis indicates that there are covalent bonds between U and U atoms in both Fmmm-U(4)He and P1̄-U(6)He. Regarding the elastic modulus of α-U, the addition of helium has certain influence on the mechanical properties of uranium. Besides, first-principles molecular dynamics simulations were carried out to study the dynamical behavior of Fmmm-U(4)He and P1̄-U(6)He at high-temperature. It was found that Fmmm-U(4)He and P1̄-U(6)He undergo one-dimensional superionic phase transitions at 150 GPa. Our study revealed the exotic structure of U-He compounds beyond the formation of bubbles under high-pressure and high-temperature, which might be relevant to the performance and safety issues of nuclear materials under extreme conditions. FAU - Cao, Ye AU - Cao Y AUID- ORCID: 0009-0006-7093-1662 AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Song, Hongxing AU - Song H AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Yan, Xiaozhen AU - Yan X AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Wang, Hao AU - Wang H AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Wang, Yufeng AU - Wang Y AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Wu, Fengchao AU - Wu F AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Zhang, Leilei AU - Zhang L AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Wu, Qiang AU - Wu Q AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. FAU - Geng, Huayun AU - Geng H AD - National Key Laboratory of Shock Wave and Detonation Physics, Institute of Fluid Physics, China Academy of Engineering Physics, Mianyang, Sichuan 621900, P. R. China. hxsong555@163.com. AD - HEDPS, Center for Applied Physics and Technology, and College of Engineering, Peking University, Beijing 100871, P. R. China. LA - eng PT - Journal Article DEP - 20240717 PL - England TA - Phys Chem Chem Phys JT - Physical chemistry chemical physics : PCCP JID - 100888160 SB - IM EDAT- 2024/07/03 06:42 MHDA- 2024/07/03 06:43 CRDT- 2024/07/03 04:16 PHST- 2024/07/03 06:43 [medline] PHST- 2024/07/03 06:42 [pubmed] PHST- 2024/07/03 04:16 [entrez] AID - 10.1039/d4cp02037e [doi] PST - epublish SO - Phys Chem Chem Phys. 2024 Jul 17;26(28):19228-19235. doi: 10.1039/d4cp02037e. PMID- 21315974 OWN - NLM STAT- MEDLINE DCOM- 20110324 LR - 20111104 IS - 1095-9998 (Electronic) IS - 0740-0020 (Linking) VI - 28 IP - 2 DP - 2011 Apr TI - Germination and outgrowth of spores of Bacillus cereus group members: diversity and role of germinant receptors. PG - 199-208 LID - 10.1016/j.fm.2010.03.015 [doi] AB - Bacillus cereus is a gram-positive, facultative anaerobic, endospore-forming toxicogenic human pathogen. Endospores are highly specialized, metabolically dormant cell types that are resistant to extreme environmental conditions, including heat, dehydration and other physical stresses. B. cereus can enter a range of environments, and can in its spore form, survive harsh conditions. If these conditions become favorable, spores can germinate and grow out and reach considerable numbers in a range of environments including processed foods. Certainly the last decade, when consumer preferences have shifted to mildly processed food, new opportunities arose for spore-forming spoilage and pathogenic organisms. Only rigorous methods have been shown to be capable of destroying all spores present in food, thus a shift toward e.g., milder heat preservation strategies, may result in low but significant amounts of viable spores in food products. Hence, the need for a mild spore destruction strategy is eminent including control of spore outgrowth. Consequently, there is a large interest in triggering spore germination in foodstuffs, since germinated spores have lost the extreme resistance of dormant spores and are relatively easy to kill. Another option could be to prevent germination so that no dangerous levels can be reached. This contribution will focus on germination and outgrowth characteristics of B. cereus and other members of the B. cereus group, providing an overview of the niches these spore-formers can occupy, the signals that trigger germination, and how B. cereus copes with these wake-up calls in different environments including foods, during food processing and upon interaction with the human host. CI - Copyright © 2010 Elsevier Ltd. All rights reserved. FAU - Abee, Tjakko AU - Abee T AD - TI Food and Nutrition (TIFN), Wageningen, The Netherlands. tjakko.abee@wur.nl FAU - Groot, Masja Nierop AU - Groot MN FAU - Tempelaars, Marcel AU - Tempelaars M FAU - Zwietering, Marcel AU - Zwietering M FAU - Moezelaar, Roy AU - Moezelaar R FAU - van der Voort, Menno AU - van der Voort M LA - eng PT - Journal Article PT - Review DEP - 20100408 PL - England TA - Food Microbiol JT - Food microbiology JID - 8601127 SB - IM MH - Bacillus cereus/*physiology MH - *Consumer Product Safety MH - Food Contamination/*analysis MH - Food Handling/standards MH - Food Microbiology MH - Humans MH - Spores, Bacterial/*growth & development EDAT- 2011/02/15 06:00 MHDA- 2011/03/25 06:00 CRDT- 2011/02/15 06:00 PHST- 2009/12/18 00:00 [received] PHST- 2010/03/19 00:00 [revised] PHST- 2010/03/25 00:00 [accepted] PHST- 2011/02/15 06:00 [entrez] PHST- 2011/02/15 06:00 [pubmed] PHST- 2011/03/25 06:00 [medline] AID - S0740-0020(10)00057-2 [pii] AID - 10.1016/j.fm.2010.03.015 [doi] PST - ppublish SO - Food Microbiol. 2011 Apr;28(2):199-208. doi: 10.1016/j.fm.2010.03.015. Epub 2010 Apr 8. PMID- 39309285 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240924 IS - 2093-7911 (Print) IS - 2093-7997 (Electronic) IS - 2093-7911 (Linking) VI - 15 IP - 3 DP - 2024 Sep TI - How Resilient are Lucid Motivators? Endeavoring Reforms for Effects of Psycho-social Factors on Workers Health Through Concurrent Engineering. PG - 327-337 LID - 10.1016/j.shaw.2024.05.003 [doi] AB - BACKGROUND: As the tremendous impact of extreme workloads, arduous working conditions, and disorganization disrupt humane job definitions in some industries, the need for workplace re-articulation was interfered to ameliorate psycho-social factors and suggest organizational intervention strategies. Especially for colossally wounded health-care (HC) systems, today it is now even more unrealizable to retain workforce resilience considering the immense impact of overwhelming working conditions. METHODS: This study introduces employment of concurrent engineering tools to re-design humane workplaces annihilating abatement over devoured resources. The study handles HC-workforce resilience in a pioneering motive to introduce transformation of well-known motivators and proposes solutions for retention and resilience issues grounding on HC workers' own voice. RESULTS: The proposed adjustable approach introduces integral use of focus group studies, SWARA, and QFD methods, and was practiced on a real-world case regarding Turkish HC workforce. The paper also presents widespread effects of findings by tendering generalized psycho-social rehabilitation strategies. Results confirmed the modifications of the most potent incessant motivators. CONCLUSION: "Burn out issues" and "Challenging work" were found as the most important motivator and satisfier, respectively, to be exigently fulfilled. Corrective interventions, required resolutions, and workplace articulation connotations were arbitrated in terms of entire outcomes on four dimensions in three different planning periods considering the current status, repercussions of pandemic, and contingency of similar catastrophes. Descriptive illustrations were additionally presented to support deducted interpretations. CI - © 2024 The Authors. Published by Elsevier B.V. on behalf of Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency. FAU - Yılmaz Kaya, Burcu AU - Yılmaz Kaya B AD - Industrial Engineering Department, Faculty of Engineering, Gazi University, Ankara, Turkey. FAU - Kılıç Delice, Elif AU - Kılıç Delice E AD - Industrial Engineering Department, Faculty of Engineering, Atatürk University, Erzurum, Turkey. LA - eng PT - Journal Article DEP - 20240517 PL - Korea (South) TA - Saf Health Work JT - Safety and health at work JID - 101542940 PMC - PMC11410732 OTO - NOTNLM OT - Concurrent engineering OT - Health and safety services OT - Human factors analysis OT - Multi-criteria decision-making OT - Occupational health and safety EDAT- 2024/09/23 07:30 MHDA- 2024/09/23 07:31 PMCR- 2024/05/17 CRDT- 2024/09/23 05:47 PHST- 2022/12/08 00:00 [received] PHST- 2024/05/08 00:00 [revised] PHST- 2024/05/13 00:00 [accepted] PHST- 2024/09/23 07:31 [medline] PHST- 2024/09/23 07:30 [pubmed] PHST- 2024/09/23 05:47 [entrez] PHST- 2024/05/17 00:00 [pmc-release] AID - S2093-7911(24)00035-0 [pii] AID - 10.1016/j.shaw.2024.05.003 [doi] PST - ppublish SO - Saf Health Work. 2024 Sep;15(3):327-337. doi: 10.1016/j.shaw.2024.05.003. Epub 2024 May 17. PMID- 24220663 OWN - NLM STAT- MEDLINE DCOM- 20140124 LR - 20240109 IS - 1879-3460 (Electronic) IS - 0168-1605 (Linking) VI - 168-169 DP - 2014 Jan 3 TI - Impact of phytopathogen infection and extreme weather stress on internalization of Salmonella Typhimurium in lettuce. PG - 24-31 LID - S0168-1605(13)00476-5 [pii] LID - 10.1016/j.ijfoodmicro.2013.10.010 [doi] AB - Internalization of human pathogens, common in many types of fresh produce, is a threat to human health since the internalized pathogens cannot be fully inactivated/removed by washing with water or sanitizers. Given that pathogen internalization can be affected by many environmental factors, this study was conducted to investigate the influence of two types of plant stress on the internalization of Salmonella Typhimurium in iceberg lettuce during pre-harvest. The stresses were: abiotic (water stress induced by extreme weather events) and biotic (phytopathogen infection by lettuce mosaic virus [LMV]). Lettuce with and without LMV infection were purposefully contaminated with green fluorescence protein-labeled S. Typhimurium on the leaf surfaces. Lettuce was also subjected to water stress conditions (drought and storm) which were simulated by irrigating with different amounts of water. The internalized S. Typhimurium in the different parts of the lettuce were quantified by plate count and real-time quantitative PCR and confirmed with a laser scanning confocal microscope. Salmonella internalization occurred under the conditions outlined above; however internalization levels were not significantly affected by water stress alone. In contrast, the extent of culturable S. Typhimurium internalized in the leafy part of the lettuce decreased when infected with LMV under water stress conditions and contaminated with high levels of S. Typhimurium. On the other hand, LMV-infected lettuce showed a significant increase in the levels of culturable bacteria in the roots. In conclusion, internalization was observed under all experimental conditions when the lettuce surface was contaminated with S. Typhimurium. However, the extent of internalization was only affected by water stress when lettuce was infected with LMV. CI - © 2013. FAU - Ge, Chongtao AU - Ge C AD - Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA. FAU - Lee, Cheonghoon AU - Lee C FAU - Nangle, Ed AU - Nangle E FAU - Li, Jianrong AU - Li J FAU - Gardner, David AU - Gardner D FAU - Kleinhenz, Matthew AU - Kleinhenz M FAU - Lee, Jiyoung AU - Lee J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131023 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM MH - Colony Count, Microbial MH - Consumer Product Safety MH - *Food Microbiology MH - Lactuca/*microbiology MH - Plant Roots/microbiology MH - Salmonella typhimurium/*physiology MH - *Stress, Physiological MH - *Weather OTO - NOTNLM OT - Internalization OT - Lettuce OT - Lettuce mosaic virus OT - Salmonella Typhimurium OT - Water stress EDAT- 2013/11/14 06:00 MHDA- 2014/01/25 06:00 CRDT- 2013/11/14 06:00 PHST- 2013/06/13 00:00 [received] PHST- 2013/10/11 00:00 [revised] PHST- 2013/10/15 00:00 [accepted] PHST- 2013/11/14 06:00 [entrez] PHST- 2013/11/14 06:00 [pubmed] PHST- 2014/01/25 06:00 [medline] AID - S0168-1605(13)00476-5 [pii] AID - 10.1016/j.ijfoodmicro.2013.10.010 [doi] PST - ppublish SO - Int J Food Microbiol. 2014 Jan 3;168-169:24-31. doi: 10.1016/j.ijfoodmicro.2013.10.010. Epub 2013 Oct 23. PMID- 28946364 OWN - NLM STAT- MEDLINE DCOM- 20171106 LR - 20231213 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 240 DP - 2018 Feb 1 TI - Channel directed rutin nano-encapsulation in phytoferritin induced by guanidine hydrochloride. PG - 935-939 LID - S0308-8146(17)31240-2 [pii] LID - 10.1016/j.foodchem.2017.07.088 [doi] AB - Phytoferritin cage has a nano-sized cavity to encapsulate bioactive molecules. In this work, a novel approach is presented that guanidine hydrochloride (GuHCl) (2mM) can expand the channel of apo-soybean seed ferritin (apoSSF) and promote the encapsulation of rutin molecules in apoSSF at pH 7.0 without the disassembly of the protein cage. Upon removal of GuHCl from SSF, a rutin encapsulation ratio of 10.1% was obtained; and the prepared rutin-loaded ferritin nanoparticles were homogeneously distributed, showing a shell-like morphology with a size of 12nm. By virtue of this interesting method, core molecules can be encapsulated within the ferritin cage in a benign condition without extreme pH changes, which is beneficial for the stability and bioactivity of the pH-sensitive molecules in food encapsulation and delivery of functional molecules. CI - Copyright © 2017 Elsevier Ltd. All rights reserved. FAU - Yang, Rui AU - Yang R AD - Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address: yangrui@tust.edu.cn. FAU - Liu, Yuqian AU - Liu Y AD - Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China. FAU - Blanchard, Chris AU - Blanchard C AD - ARC Industrial Transformation Training Centre for Functional Grains, Wagga Wagga, NSW 2678, Australia. FAU - Zhou, Zhongkai AU - Zhou Z AD - Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address: zkzhou@tust.edu.cn. LA - eng PT - Journal Article DEP - 20170718 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (phytoferritin) RN - 5G06TVY3R7 (Rutin) RN - 9007-73-2 (Ferritins) RN - JU58VJ6Y3B (Guanidine) SB - IM MH - Ferritins MH - Guanidine MH - Rutin/*analysis MH - Glycine max OTO - NOTNLM OT - Ferritin cage OT - Guanidine hydrochloride OT - Nano-encapsulation OT - Protein channel EDAT- 2017/09/28 06:00 MHDA- 2017/11/07 06:00 CRDT- 2017/09/27 06:00 PHST- 2017/04/03 00:00 [received] PHST- 2017/06/13 00:00 [revised] PHST- 2017/07/18 00:00 [accepted] PHST- 2017/09/27 06:00 [entrez] PHST- 2017/09/28 06:00 [pubmed] PHST- 2017/11/07 06:00 [medline] AID - S0308-8146(17)31240-2 [pii] AID - 10.1016/j.foodchem.2017.07.088 [doi] PST - ppublish SO - Food Chem. 2018 Feb 1;240:935-939. doi: 10.1016/j.foodchem.2017.07.088. Epub 2017 Jul 18. PMID- 37542004 OWN - NLM STAT- MEDLINE DCOM- 20230901 LR - 20240419 IS - 1432-1106 (Electronic) IS - 0014-4819 (Print) IS - 0014-4819 (Linking) VI - 241 IP - 9 DP - 2023 Sep TI - Under pressure-the influence of hypergravity on electrocortical activity and neurocognitive performance. PG - 2249-2259 LID - 10.1007/s00221-023-06677-8 [doi] AB - The effects of hypergravity and the associated increased pressure on the human body have not yet been studied in detail, but are of great importance for the safety of astronauts on space missions and could have a long-term impact on rehabilitation strategies for neurological patients. Considering the plans of international space agencies with the exploration of Mars and Moon, it is important to explore the effects of both extremes, weightlessness and hypergravity. During parabolic flights, a flight manoeuvre that artificially creates weightlessness and hypergravity, electrocortical activity as well as behavioural parameters (error rate and reaction time) and neuronal parameters (event-related potentials P300 and N200) were examined with an electroencephalogram. Thirteen participants solved a neurocognitive task (mental arithmetic task as a primary task and oddball paradigm as a secondary task) within normal as well as hypergravity condition in fifteen consecutive parabolas for 22 s each. No changes between the different gravity levels could be observed for the behavioural parameters and cortical current density. A significantly lower P300 amplitude was observed in 1 G, triggered by the primary task and the target sound of the oddball paradigm. The N200, provoked by the sounds of the oddball paradigm, revealed a higher amplitude in 1.8 G. A model established by Kohn et al. (2018) describing changes in neural communication with decreasing gravity can be used here as an explanatory approach. The fluid shift increases the intracranial pressure, decreases membrane viscosity and influences the open state probability of ion channels. This leads to an increase in the resting membrane potential, and the threshold for triggering an action potential can be reached more easily. The question now arises whether the observed changes are linear or whether they depend on a specific threshold. CI - © 2023. The Author(s). FAU - Badalì, Constance AU - Badalì C AUID- ORCID: 0000-0001-9250-9426 AD - Institute of Movement and Neurosciences, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. c.badali@dshs-koeln.de. FAU - Wollseiffen, Petra AU - Wollseiffen P AD - Institute of Movement and Neurosciences, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. AD - Centre for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Cologne, Germany. FAU - Schneider, Stefan AU - Schneider S AD - Institute of Movement and Neurosciences, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. AD - Centre for Health and Integrative Physiology in Space (CHIPS), German Sport University Cologne, Cologne, Germany. LA - eng GR - 50WB2020/Deutsches Zentrum für Luft- und Raumfahrt/ PT - Journal Article DEP - 20230804 PL - Germany TA - Exp Brain Res JT - Experimental brain research JID - 0043312 SB - IM MH - Humans MH - *Hypergravity/adverse effects MH - *Weightlessness MH - Electroencephalography MH - Evoked Potentials MH - Reaction Time MH - *Space Flight PMC - PMC10471660 OTO - NOTNLM OT - Behavioural and neuronal parameters OT - Brain activity OT - EEG OT - ERP OT - Hypergravity OT - Parabolic flight COIS- The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2023/08/05 05:42 MHDA- 2023/09/01 06:42 PMCR- 2023/08/04 CRDT- 2023/08/04 23:04 PHST- 2023/04/16 00:00 [received] PHST- 2023/07/25 00:00 [accepted] PHST- 2023/09/01 06:42 [medline] PHST- 2023/08/05 05:42 [pubmed] PHST- 2023/08/04 23:04 [entrez] PHST- 2023/08/04 00:00 [pmc-release] AID - 10.1007/s00221-023-06677-8 [pii] AID - 6677 [pii] AID - 10.1007/s00221-023-06677-8 [doi] PST - ppublish SO - Exp Brain Res. 2023 Sep;241(9):2249-2259. doi: 10.1007/s00221-023-06677-8. Epub 2023 Aug 4. PMID- 12076989 OWN - NLM STAT- MEDLINE DCOM- 20020726 LR - 20190616 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 962 DP - 2002 May TI - The clinical safety of viagra. PG - 378-88 AB - Erectile dysfunction (ED) in men is amenable to correction with Viagra in a majority of patients. The accumulated experience of prescribing Viagra across the broad continuum of men suffering from ED is sufficient for a meaningful assessment of the safety of Viagra in clinical practice. The use of Viagra necessitates caution in cardiac failure and when used within six months of acute myocardial infarction and stroke. It is inadvisable in patients with unstable angina pectoris. The co-administration of Viagra with organic nitrates, for example, glyceryl trinitrate or isosorbide dinitrate, is unsafe. The relative contraindications to Viagra in cardiovascular disease are uncontrolled hypertension and impaired cardiac reserve. With respect to interactions with other drugs, the potential influence on the metabolism of Viagra by medications that affect the cytochrome-P-450 system does not translate into clinical effects. The vasodilatory properties of sildenafil citrate are largely responsible for unwanted effects. The most common side effects are headache, flushing (due to vasodilation), and dyspepsia (due to relaxation of the smooth muscle of the gastroesophageal sphincter with reflux). In the recommended single-dose range (25-100 mg), the use of Viagra for erectile dysfunction, in the absence of contraindications, is extremely safe provided the drug is taken under proper conditions. FAU - Lim, Peter H C AU - Lim PH AD - Department of Urology, Changi General Hospital, Singapore. FAU - Moorthy, P AU - Moorthy P FAU - Benton, Kenneth G F AU - Benton KG LA - eng PT - Journal Article PT - Review PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 0 (Piperazines) RN - 0 (Purines) RN - 0 (Sulfones) RN - 0 (Vasodilator Agents) RN - BW9B0ZE037 (Sildenafil Citrate) SB - IM MH - Contraindications MH - Drug Interactions MH - Erectile Dysfunction/*drug therapy MH - Humans MH - Male MH - Penile Erection/drug effects/physiology MH - Piperazines/adverse effects/*therapeutic use MH - Purines MH - Sildenafil Citrate MH - Sulfones MH - Vasodilator Agents/adverse effects/therapeutic use RF - 35 EDAT- 2002/06/22 10:00 MHDA- 2002/07/27 10:01 CRDT- 2002/06/22 10:00 PHST- 2002/06/22 10:00 [pubmed] PHST- 2002/07/27 10:01 [medline] PHST- 2002/06/22 10:00 [entrez] AID - 10.1111/j.1749-6632.2002.tb04082.x [doi] PST - ppublish SO - Ann N Y Acad Sci. 2002 May;962:378-88. doi: 10.1111/j.1749-6632.2002.tb04082.x. PMID- 17448267 OWN - NLM STAT- MEDLINE DCOM- 20070925 LR - 20141120 IS - 1754-0453 (Print) IS - 1754-0453 (Linking) VI - 13 IP - 1 DP - 2007 Mar TI - Advances in the surgical management of prolapse. PG - 38-43 AB - Prolapse is an extremely common condition, for which 11% of women will have a surgical procedure at some point in their lives. The recurrence rate after most of the traditional surgical procedures is high and upto 29% of women who have had surgery for prolapse will require a further operation. In order to improve the surgical outcome, there is currently much interest in the use of grafts to augment traditional repairs and new procedures have been developed using specifically developed grafts. These have been combined with minimally invasive surgical techniques in an attempt to reduce surgical morbidity. These procedures may improve the outcome of surgery for prolapse. However, there is currently a lack of long-term data from randomized trials to demonstrate their effectiveness and safety. FAU - Slack, Alex AU - Slack A AD - Department of Urogynaecology, John Radcliffe Hospital, Oxford, UK. alexslack@ukonline.co.uk FAU - Jackson, Simon AU - Jackson S LA - eng PT - Journal Article PT - Review PL - England TA - Menopause Int JT - Menopause international JID - 101303618 SB - IM MH - Female MH - Gynecologic Surgical Procedures MH - Humans MH - Minimally Invasive Surgical Procedures MH - Severity of Illness Index MH - Surgical Mesh MH - Uterine Prolapse/pathology/*surgery RF - 48 EDAT- 2007/04/24 09:00 MHDA- 2007/09/26 09:00 CRDT- 2007/04/24 09:00 PHST- 2007/04/24 09:00 [pubmed] PHST- 2007/09/26 09:00 [medline] PHST- 2007/04/24 09:00 [entrez] AID - 10.1258/175404507780456809 [doi] PST - ppublish SO - Menopause Int. 2007 Mar;13(1):38-43. doi: 10.1258/175404507780456809. PMID- 39192830 OWN - NLM STAT- MEDLINE DCOM- 20241212 LR - 20241212 IS - 1744-7593 (Electronic) IS - 1742-5247 (Linking) VI - 21 IP - 12 DP - 2024 Dec TI - Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals. PG - 1879-1888 LID - 10.1080/17425247.2024.2394112 [doi] AB - BACKGROUND: Cyltezo® (Adalimumab-adbm) is an FDA-approved interchangeable biosimilar for Humira® (adalimumab reference product [RP]) that helps treat chronic inflammatory conditions. Adalimumab-adbm is administered via an autoinjector, the adalimumab-adbm pen. This study assessed user opinions related to usability, perceptions, convenience, safety features, and acceptability of the adalimumab-adbm pen. METHODS: Ninety-eight Humira Pen users, 100 biologics pen naïve patients, and 99 healthcare professionals simulated the use of the adalimumab-adbm pen on injection pads. Opinions were captured with a validated questionnaire using Likert-type scales during moderated interviews. Binomial tests were conducted for top-two rating percentages. RESULTS: Nearly 90% of participants found the adalimumab-adbm pen 'easy' or 'very easy' to use, handle, and learn how to use. Almost 90% of volunteers thought the pen was 'very' or 'extremely' solid and convenient to use at home. Around 80% found the pen to be 'very' or 'extremely' comfortable. Over 90% of respondents said they would be 'satisfied' or 'very satisfied' with the safety features and the device itself. Nearly 90% of respondents indicated being 'very' or 'extremely' open to adopting the adalimumab-adbm pen. CONCLUSIONS: The adalimumab-adbm pen provided users with a positive experience with features that benefit perceptions of usability, handling, safety, convenience, and acceptability. FAU - Perez, Raul AU - Perez R AD - Noble International LLC, Orlando, FL, USA. FAU - Suman, Julie D AU - Suman JD AD - AptarGroup Inc, Congers, NY, USA. FAU - Reynolds, Joe AU - Reynolds J AD - Noble International LLC, Orlando, FL, USA. LA - eng PT - Journal Article DEP - 20241121 PL - England TA - Expert Opin Drug Deliv JT - Expert opinion on drug delivery JID - 101228421 RN - FYS6T7F842 (Adalimumab) RN - 0 (Biosimilar Pharmaceuticals) RN - 0 (Anti-Inflammatory Agents) SB - IM MH - Humans MH - *Adalimumab/administration & dosage MH - Adult MH - Male MH - Female MH - Middle Aged MH - Surveys and Questionnaires MH - *Biosimilar Pharmaceuticals/administration & dosage MH - Anti-Inflammatory Agents/administration & dosage MH - Young Adult MH - Health Personnel/psychology MH - Aged MH - Patient Acceptance of Health Care MH - Self Administration MH - Injections OTO - NOTNLM OT - Subcutaneous drug delivery OT - autoinjector OT - autoinjector user experience OT - drug delivery device OT - patient Experience OT - patient acceptability EDAT- 2024/08/28 08:42 MHDA- 2024/12/12 12:27 CRDT- 2024/08/28 04:02 PHST- 2024/12/12 12:27 [medline] PHST- 2024/08/28 08:42 [pubmed] PHST- 2024/08/28 04:02 [entrez] AID - 10.1080/17425247.2024.2394112 [doi] PST - ppublish SO - Expert Opin Drug Deliv. 2024 Dec;21(12):1879-1888. doi: 10.1080/17425247.2024.2394112. Epub 2024 Nov 21. PMID- 12583057 OWN - NLM STAT- MEDLINE DCOM- 20030722 LR - 20061115 IS - 1671-7104 (Print) IS - 1671-7104 (Linking) VI - 23 IP - 4 DP - 1999 Jul TI - [The study of the control system of new generation EECP]. PG - 187-9 AB - A new algorithm for the inflation and deflation timing of the Enhanced External Counterpulsation (EECP) have been developed, A pentium PC and 16 bit microcontroller with parallel interrupt communication were used for developing a new kind of EECP system. The 16 bit microcontroller was used to collect and pre-process the ECG and EECP signals. The pre-processing data is transmitted to PC by the parallel communication interface. According to the new algorithm, PC sent out the sequential control signals and monitor the state of EECP. It is necessary to synchronize the time of aortic valve closure and diastolic augmentation during EECP, under the condition of the patients' safety, the effect of therapy have been extremely improved. FAU - Li, H AU - Li H AD - Dept. BME, Capital University of Medical Sciences. FAU - Zheng, Z AU - Zheng Z LA - chi PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - China TA - Zhongguo Yi Liao Qi Xie Za Zhi JT - Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation JID - 9426153 SB - IM MH - *Algorithms MH - Counterpulsation/*instrumentation MH - Humans MH - Software EDAT- 2003/02/14 04:00 MHDA- 2003/07/23 05:00 CRDT- 2003/02/14 04:00 PHST- 2003/02/14 04:00 [pubmed] PHST- 2003/07/23 05:00 [medline] PHST- 2003/02/14 04:00 [entrez] PST - ppublish SO - Zhongguo Yi Liao Qi Xie Za Zhi. 1999 Jul;23(4):187-9. PMID- 32024578 OWN - NLM STAT- MEDLINE DCOM- 20200429 LR - 20200429 IS - 1751-732X (Electronic) IS - 1751-7311 (Linking) VI - 14 IP - S1 DP - 2020 Mar TI - Review: Challenges for dairy cow production systems arising from climate changes. PG - s196-s203 LID - 10.1017/S1751731119003239 [doi] AB - The so-called global change refers to changes on a planetary scale. The term encompasses various issues like resource use, energy development, population growth, land use and land cover, carbon and nitrogen cycle, pollution and health, and climate change. The paper deals with challenges for dairy cattle production systems in Europe arising from climate change as one part of global changes. Global warming is increasing, and therefore ecosystems, plant and animal biodiversity, and food security and safety are at risk. It is already accepted knowledge that the direct and indirect effects of global warming in combination with an increasing frequency of weather extremes are a serious issue for livestock production, even in moderate climate zones like Central Europe. The potential and already-measurable effects of climate change (including increase in temperature, frequency of hot days and heat waves), in particular the challenges on grassland production, fodder quality, nutrition in general, cow welfare, health as well as performance of dairy production, will be reviewed. Indirect and direct effects on animals are correlated with their performance. There are clear indications that with selection for high-yielding animals the sensitivity to climate changes increases. Cumulative effects (e.g. higher temperature plus increased pathogen and their vectors loads) do strengthen these impacts. To cope with the consequences several possible adaptation and mitigation strategies must be established on different levels. This includes changes in the production systems (e.g. management, barn, feeding), breeding strategies and health management. FAU - Gauly, M AU - Gauly M AUID- ORCID: 0000-0003-4212-5437 AD - Faculty of Science and Technology, Livestock Production Systems, Free University of Bolzano, Universitätsplatz 5, 39100 Bolzano, Italy. FAU - Ammer, S AU - Ammer S AD - Division of Livestock Production Systems, Department of Animal Sciences, University of Göttingen, Albrecht-Thaer-Weg 3, 37075 Göttingen, Germany. LA - eng PT - Journal Article PT - Review PL - England TA - Animal JT - Animal : an international journal of animal bioscience JID - 101303270 SB - IM MH - *Acclimatization MH - *Adaptation, Physiological MH - Animal Feed MH - Animals MH - Cattle/*physiology MH - *Climate Change MH - Ecosystem MH - Female MH - Hot Temperature OTO - NOTNLM OT - adaptation OT - cattle OT - climatic conditions OT - global warming OT - milk production EDAT- 2020/02/07 06:00 MHDA- 2020/04/30 06:00 CRDT- 2020/02/07 06:00 PHST- 2020/02/07 06:00 [entrez] PHST- 2020/02/07 06:00 [pubmed] PHST- 2020/04/30 06:00 [medline] AID - S1751731119003239 [pii] AID - 10.1017/S1751731119003239 [doi] PST - ppublish SO - Animal. 2020 Mar;14(S1):s196-s203. doi: 10.1017/S1751731119003239. PMID- 36723306 OWN - NLM STAT- MEDLINE DCOM- 20230203 LR - 20230203 IS - 0043-5147 (Print) IS - 0043-5147 (Linking) VI - 75 IP - 12 DP - 2022 TI - OCCUPATIONAL SAFETY AND HYGIENE OF HEALTHCARE PROFESSIONALS IN THE CONTEXT OF HOSPITAL ENVIRONMENT SAFETY. PG - 2933-2938 LID - 10.36740/WLek202212107 [doi] AB - OBJECTIVE: The aim: This study was conducted to carry out a comprehensive assessment of the occupational safety and health of medical workers. PATIENTS AND METHODS: Materials and methods: The study involved a questionnaire survey and full-scale physiological and hygienic research using bibliosemantic, questionnaire, hygienic, and statistical methods. RESULTS: Results: In the course of research it was recorded that the work of surgeons (according to the criteria of the current "Hygienic classification of work") is characterized by high intensity (class 3.2), high probability of exposure to infectious agents (class 3.3, and 4), harmful effects of physical factors (class 3.1 ), which according to the criteria of the general hygienic assessment of working conditions according to the degree of harmfulness and danger allows being assigned to class 3.3 ("harmful") and 4 ("dangerous"), respectively. Such working conditions provoke an increase in chronic morbidity (industrial and temporary disability), lead to the development of occupational diseases, and can pose a threat to the lives of workers. The need to focus attention on assessing the safety of hospitals in emergencies not only on issues of occupational safety and health but also on the stability and reliability of hospitals in such extreme conditions. CONCLUSION: Conclusions: The work process of doctors is characterized by the impact on their body of a complex of unfavorable production factors of psycho-physiological, biological, physical, and chemical nature, among which the leaders are high labor intensity due to intellectual and emotional load, irrational mode of work and rest, and biological factors. FAU - Yavorovskyi, Oleksandr P AU - Yavorovskyi OP AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. FAU - Brukhno, Roman P AU - Brukhno RP AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. FAU - Omelchuk, Sergii T AU - Omelchuk ST AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. FAU - Skaletsky, Yurii M AU - Skaletsky YM AD - LABORATORY OF THE SECURITY STRATEGIES IN PUBLIC HEALTH, STATE INSTITUTION "O.M. MARZIEIEV INSTITUTE FOR PUBLIC HEALTH" NAMSU, KYIV, UKRAINE. FAU - Paustovskyi, Yurii O AU - Paustovskyi YO AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. FAU - Zenkina, Valentyna I AU - Zenkina VI AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. FAU - Zinchenko, Tetyana O AU - Zinchenko TO AD - BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE. LA - eng PT - Journal Article PL - Poland TA - Wiad Lek JT - Wiadomosci lekarskie (Warsaw, Poland : 1960) JID - 9705467 SB - IM MH - Humans MH - *Occupational Health MH - Reproducibility of Results MH - Industry MH - *Occupational Diseases MH - Hygiene MH - Delivery of Health Care MH - *Occupational Exposure OTO - NOTNLM OT - medical staff OT - occupational safety OT - occupational hygiene OT - safe hospital environment EDAT- 2023/02/02 06:00 MHDA- 2023/02/04 06:00 CRDT- 2023/02/01 09:37 PHST- 2023/02/01 09:37 [entrez] PHST- 2023/02/02 06:00 [pubmed] PHST- 2023/02/04 06:00 [medline] AID - 10.36740/WLek202212107 [doi] PST - ppublish SO - Wiad Lek. 2022;75(12):2933-2938. doi: 10.36740/WLek202212107. PMID- 39085133 OWN - NLM STAT- MEDLINE DCOM- 20240911 LR - 20240927 IS - 1347-7439 (Electronic) IS - 0916-7250 (Print) IS - 0916-7250 (Linking) VI - 86 IP - 9 DP - 2024 Sep 10 TI - Evaluation of the stress state based on fecal corticosterone metabolite concentrations in captive penguins in Japan. PG - 992-998 LID - 10.1292/jvms.24-0112 [doi] AB - Fecal corticosterone metabolite (FCM) concentrations, which can be determined noninvasively, have recently been explored as a stress indicator in birds. In our study, we measured FCM concentrations in penguins under nonmolting or molting conditions, cool or hot season, diseased condition, and incubation period. These measurements were conducted in an aquarium that housed king penguins, gentoo penguins, and African penguins. This study aimed to investigate the validity of fecal matter as a stress indicator. Our findings revealed that FCM concentrations were significantly higher in molting individuals than in nonmolting individuals. Compared with the cool season, FCM concentrations were significantly higher in penguins housed outdoors during the hot season. However, no differences were observed in penguins housed indoors. Diseased individuals and an incubating individual showed notably higher FCM concentrations than healthy individuals. Interestingly, the FCM concentration in king penguin that underwent cataract surgery was extremely high before the surgery. However, 1 month postsurgery, it decreased to a level similar to that of healthy individuals. We observed increased FCM concentrations in penguins considered to be exposed to stressors. Notably, FCM concentration decreased after removing the stress factor. The FCM concentration was found to be consistent with the stress state of penguins, suggesting its usefulness as a stress indicator. FAU - Itoh, Megumi AU - Itoh M AD - Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan. FAU - Kitahara, Misato AU - Kitahara M AD - Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan. FAU - Sawayama, Nanako AU - Sawayama N AD - Noboribetsu Marine Park Nixe, Hokkaido, Japan. FAU - Matsumoto, Naoya AU - Matsumoto N AD - School of Veterinary Medicine, Azabu University, Kanagawa, Japan. FAU - Toyotome, Takahito AU - Toyotome T AD - Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan. AD - Diagnostic Center for Animal Health and Food Safety, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan. AD - Medical Mycology Research Center, Chiba University, Chiba, Japan. FAU - Yamada, Kazutaka AU - Yamada K AD - School of Veterinary Medicine, Azabu University, Kanagawa, Japan. LA - eng PT - Journal Article DEP - 20240801 PL - Japan TA - J Vet Med Sci JT - The Journal of veterinary medical science JID - 9105360 RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - *Spheniscidae/metabolism MH - *Feces/chemistry MH - *Corticosterone/analysis/metabolism MH - *Stress, Physiological MH - Japan MH - Seasons MH - Male MH - Bird Diseases/metabolism MH - Animals, Zoo MH - Female MH - Molting/physiology PMC - PMC11422689 OTO - NOTNLM OT - captive penguin OT - diseased individual OT - fecal corticosterone metabolite OT - hot season OT - molting period COIS- The authors declare no conflicts of interest. EDAT- 2024/08/01 00:42 MHDA- 2024/09/12 00:42 PMCR- 2024/09/01 CRDT- 2024/07/31 22:34 PHST- 2024/09/12 00:42 [medline] PHST- 2024/08/01 00:42 [pubmed] PHST- 2024/07/31 22:34 [entrez] PHST- 2024/09/01 00:00 [pmc-release] AID - 24-0112 [pii] AID - 10.1292/jvms.24-0112 [doi] PST - ppublish SO - J Vet Med Sci. 2024 Sep 10;86(9):992-998. doi: 10.1292/jvms.24-0112. Epub 2024 Aug 1. PMID- 32057309 OWN - NLM STAT- MEDLINE DCOM- 20201221 LR - 20211204 IS - 1875-7855 (Electronic) IS - 0079-6123 (Linking) VI - 251 DP - 2020 TI - Translational validity and implications of pharmacotherapies in preclinical models of Down syndrome. PG - 245-268 LID - S0079-6123(19)30198-0 [pii] LID - 10.1016/bs.pbr.2019.10.001 [doi] AB - Neurodevelopmental disorders are challenging to study in the laboratory, and despite a large investment, few novel treatments have been developed in the last decade. While animal models have been valuable in elucidating disease mechanisms and in providing insights into the function of specific genes, the predictive validity of preclinical models to test potential therapies has been questioned. In the last two decades, diverse new murine models of Down syndrome (DS) have been developed and numerous studies have demonstrated neurobiological alterations that could be responsible for the cognitive and behavioral phenotypes found in this syndrome. In many cases, similar alterations were found in murine models and in individuals with DS, although several phenotypes shown in animals have yet not been confirmed in the human condition. Some of the neurobiological alterations observed in mice have been proposed to account for their changes in cognition and behavior, and have received special attention because of being putative therapeutic targets. Those include increased oxidative stress, altered neurogenesis, overexpression of the Dyrk1A gene, GABA-mediated overinhibition and Alzheimer's disease-related neurodegeneration. Subsequently, different laboratories have tested the efficacy of pharmacotherapies targeting these alterations. Unfortunately, animal models are limited in their ability to mimic the extremely complex process of human neurodevelopment and neuropathology. Therefore, the safety and efficacy identified in animal studies are not always translated to humans, and most of the drugs tested have not demonstrated any positive effect or very limited efficacy in clinical trials. Despite their limitations, though, animal trials give us extremely valuable information for developing and testing drugs for human use that cannot be obtained from molecular or cellular experiments alone. This chapter reviews some of these therapeutic approaches and discusses some reasons that could account for the discrepancy between the findings in mouse models of DS and in humans, including: (i) the incomplete resemble of the genetic alterations of available mouse models of DS and human trisomy 21, (ii) the lack of evidence that some of the phenotypic alterations found in mice (e.g., GABA-mediated overinhibition, and alterations in adult neurogenesis) are also present in DS individuals, and (iii) the inaccuracy and/or inadequacy of the methods used in clinical trials to detect changes in the cognitive and behavioral functions of people with DS. Despite the shortcomings of animal models, animal experimentation remains an invaluable tool in developing drugs. Thus, we will also discuss how to increase predictive validity of mouse models. CI - © 2020 Elsevier B.V. All rights reserved. FAU - Rueda, Noemí AU - Rueda N AD - Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain. FAU - Flórez, Jesús AU - Flórez J AD - Department of Physiology and Pharmacology, University of Cantabria, Santander, Spain. FAU - Dierssen, Mara AU - Dierssen M AD - Cellular and Systems Neurobiology, Systems Biology Program, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Universitat Pompeu Fabra (UPF), Barcelona, Spain. FAU - Martínez-Cué, Carmen AU - Martínez-Cué C AD - Department of Physiology and Pharmacology, School of Medicine, University of Cantabria, Santander, Spain. Electronic address: carmen.martinez-cue@unican.es. LA - eng PT - Journal Article PT - Review DEP - 20191101 PL - Netherlands TA - Prog Brain Res JT - Progress in brain research JID - 0376441 SB - IM MH - *Alzheimer Disease/drug therapy/genetics/metabolism MH - Animals MH - *Disease Models, Animal MH - *Down Syndrome/drug therapy/genetics/metabolism MH - Translational Research, Biomedical/*standards OTO - NOTNLM OT - Down syndrome OT - Induced pluripotent stem cells (iPSCs) OT - Mouse models OT - Pharmacotherapies OT - Translational validity EDAT- 2020/02/15 06:00 MHDA- 2020/12/22 06:00 CRDT- 2020/02/15 06:00 PHST- 2020/02/15 06:00 [entrez] PHST- 2020/02/15 06:00 [pubmed] PHST- 2020/12/22 06:00 [medline] AID - S0079-6123(19)30198-0 [pii] AID - 10.1016/bs.pbr.2019.10.001 [doi] PST - ppublish SO - Prog Brain Res. 2020;251:245-268. doi: 10.1016/bs.pbr.2019.10.001. Epub 2019 Nov 1. PMID- 30350299 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240403 IS - 1935-973X (Print) IS - 1935-9748 (Electronic) IS - 1935-9748 (Linking) VI - 11 IP - 4 DP - 2018 Dec TI - Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee. PG - 583-592 LID - 10.1007/s12178-018-9524-x [doi] AB - PURPOSE OF REVIEW: The purpose of this review is to update the reader on the current applications of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA). This review will focus on PRP's effect on the osteoarthritic joint, how PRP compares to traditional treatments of KOA, and provide clinical feedback on the use of PRP in an orthopedic and sports medicine practice. RECENT FINDINGS: Recent research into the applications of PRP for KOA has further indicated both the efficacy and safety of PRP treatment. Although research has shown a tendency toward better efficacy at earlier stages of osteoarthritis (OA), evidence exists to indicate positive effects at all stages of OA. In summary, since KOA is an extremely prevalent condition that can be a challenge to treat, it is imperative that safe and effective nonoperative treatment methods be available to individuals that are suffering from this condition. FAU - Cook, Corey S AU - Cook CS AD - Columbia Orthopaedic Group, Columbia, MO, USA. FAU - Smith, Patrick A AU - Smith PA AD - Columbia Orthopaedic Group, Columbia, MO, USA. psmithmudoc@aol.com. AD - Department of Orthopaedic Surgery, University of Missouri, 1100 Virginia Ave., Columbia, MO, 65212, USA. psmithmudoc@aol.com. LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Rev Musculoskelet Med JT - Current reviews in musculoskeletal medicine JID - 101317803 PMC - PMC6220006 OTO - NOTNLM OT - Intra-articular OT - Knee OT - Osteoarthritis OT - PRP OT - Platelet-rich plasma COIS- CONFLICT OF INTEREST: Dr. Smith is a consultant for Arthrex and receives research support from them. Dr. Cook has no conflicts of interest. HUMAN AND ANIMAL RIGHTS AND INFORMED CONSENT: This article does not contain any studies with human or animal subjects performed by any of the authors. EDAT- 2018/10/24 06:00 MHDA- 2018/10/24 06:01 PMCR- 2018/10/22 CRDT- 2018/10/24 06:00 PHST- 2018/10/24 06:00 [pubmed] PHST- 2018/10/24 06:01 [medline] PHST- 2018/10/24 06:00 [entrez] PHST- 2018/10/22 00:00 [pmc-release] AID - 10.1007/s12178-018-9524-x [pii] AID - 9524 [pii] AID - 10.1007/s12178-018-9524-x [doi] PST - ppublish SO - Curr Rev Musculoskelet Med. 2018 Dec;11(4):583-592. doi: 10.1007/s12178-018-9524-x. PMID- 39159263 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240831 IS - 1935-2735 (Electronic) IS - 1935-2727 (Print) IS - 1935-2727 (Linking) VI - 18 IP - 8 DP - 2024 Aug TI - The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculation. PG - e0012011 LID - 10.1371/journal.pntd.0012011 [doi] LID - e0012011 AB - Rift Valley fever (RVF) is an important zoonotic viral disease affecting several species of domestic and wild ruminants, causing major economic losses and dozens of human deaths in various geographical areas of Africa, where it is endemic. Although it is not present in Europe, there is a risk of its introduction and spread linked to globalisation and climate change. At present, the only measure that could help to prevent the disease is vaccination of flocks in areas at risk of RVF. Available live attenuated vaccines are an effective means of controlling the disease, but their use is often questioned due to residual virulence, particularly in susceptible hosts such as pregnant sheep. On the other hand, no vaccine is currently licensed for use in humans. The development of safe and effective vaccines is therefore a major area of research. In previous studies, we selected under selective mutagenic pressure a highly attenuated RVFV 56/74 virus variant called 40Fp8. This virus showed an extremely attenuated phenotype in both wild-type and immunodeficient A129 (IFNARKO) mice, yet was still able to induce protective immunity after a single inoculation, thus supporting its use as a safe, live attenuated vaccine. To further investigate its safety, in this work we have analysed the attenuation level of 40Fp8 in immunosuppressed mice (A129) when administered by the intranasal route, and compared it with other attenuated RVF viruses that are the basis of vaccines in use or in development. Our results show that 40Fp8 has a much higher attenuated level than these other viruses and confirm its potential as a candidate for safe RVF vaccine development. CI - Copyright: © 2024 Borrego et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Borrego, Belén AU - Borrego B AUID- ORCID: 0000-0002-0801-9166 AD - Department of IMMUNOLOGY, PATHOLOGY AND CONTROL OF INFECTIOUS DISEASES, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. FAU - Alonso, Celia AU - Alonso C AD - Department of IMMUNOLOGY, PATHOLOGY AND CONTROL OF INFECTIOUS DISEASES, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. FAU - Moreno, Sandra AU - Moreno S AD - Department of IMMUNOLOGY, PATHOLOGY AND CONTROL OF INFECTIOUS DISEASES, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. FAU - de la Losa, Nuria AU - de la Losa N AD - Department of IMMUNOLOGY, PATHOLOGY AND CONTROL OF INFECTIOUS DISEASES, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. FAU - Sánchez-Cordón, Pedro José AU - Sánchez-Cordón PJ AD - Department of INFECTIOUS DISEASES AND GLOBAL HEALTH, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. FAU - Brun, Alejandro AU - Brun A AD - Department of IMMUNOLOGY, PATHOLOGY AND CONTROL OF INFECTIOUS DISEASES, Centro de Investigación en Sanidad Animal CISA INIA/CSIC, Valdeolmos, Madrid, Spain. LA - eng PT - Journal Article DEP - 20240819 PL - United States TA - PLoS Negl Trop Dis JT - PLoS neglected tropical diseases JID - 101291488 RN - 0 (Vaccines, Attenuated) RN - 0 (Viral Vaccines) RN - 0 (Antibodies, Viral) SB - IM MH - Animals MH - *Rift Valley Fever/prevention & control/immunology MH - *Vaccines, Attenuated/immunology/administration & dosage MH - *Rift Valley fever virus/immunology MH - Mice MH - *Viral Vaccines/immunology/administration & dosage MH - *Administration, Intranasal MH - Female MH - Vaccination/methods MH - Antibodies, Viral/blood PMC - PMC11361746 COIS- I have read the journal’s policy and the authors of this manuscript have the following competing interests: INIA-CSIC (BB and AB) has filed an international patent application (code # WO2021/245313A1) for 40-FP8 based RVF vaccines. The authors declare that the research was conducted in the absence of any commercial, financial, personal, or professional relationships that could be construed as a potential conflict of interest. EDAT- 2024/08/19 18:42 MHDA- 2024/08/31 09:50 PMCR- 2024/08/19 CRDT- 2024/08/19 14:13 PHST- 2024/02/20 00:00 [received] PHST- 2024/08/02 00:00 [accepted] PHST- 2024/08/29 00:00 [revised] PHST- 2024/08/31 09:50 [medline] PHST- 2024/08/19 18:42 [pubmed] PHST- 2024/08/19 14:13 [entrez] PHST- 2024/08/19 00:00 [pmc-release] AID - PNTD-D-24-00268 [pii] AID - 10.1371/journal.pntd.0012011 [doi] PST - epublish SO - PLoS Negl Trop Dis. 2024 Aug 19;18(8):e0012011. doi: 10.1371/journal.pntd.0012011. eCollection 2024 Aug. PMID- 38005004 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231127 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 16 IP - 22 DP - 2023 Nov 7 TI - Estimating the Slope Safety Factor Using Simple Kinematically Admissible Solutions. LID - 10.3390/ma16227074 [doi] LID - 7074 AB - Determining soil and water conditions is essential for designing the optimal foundation and safely transferring loads, including the self-weight of structures, to the ground. Excessive or uneven settlement of the subsoil may ultimately lead to the formation of structural cracks in buildings or the loss of slope stability. In extreme cases, the damage results in structural failure. This paper presents the application of simple solutions from plasticity theory-an evaluation of the upper and lower bounds of the exact solution-to estimate the slope safety factor. It is demonstrated that simple kinematically admissible mechanisms for the non-associated flow rule provide solutions are close to those obtained from the traditional Fellenius method. FAU - Bacharz, Kamil AU - Bacharz K AUID- ORCID: 0000-0002-6626-6202 AD - Department of Materials Strength and Building Structures, Kielce University of Technology, 25-314 Kielce, Poland. FAU - Bacharz, Magdalena AU - Bacharz M AUID- ORCID: 0000-0001-8204-1938 AD - Department of Materials Strength and Building Structures, Kielce University of Technology, 25-314 Kielce, Poland. FAU - Trąmpczyński, Wiesław AU - Trąmpczyński W AUID- ORCID: 0000-0003-0932-2666 AD - Department of Materials Strength and Building Structures, Kielce University of Technology, 25-314 Kielce, Poland. LA - eng PT - Journal Article DEP - 20231107 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC10672178 OTO - NOTNLM OT - factor of safety OT - kinematically admissible mechanisms OT - slopes OT - soil mechanics OT - the Fellenius method OT - theory of plasticity COIS- The authors declare no conflict of interest. EDAT- 2023/11/25 12:45 MHDA- 2023/11/25 12:46 PMCR- 2023/11/07 CRDT- 2023/11/25 01:25 PHST- 2023/07/29 00:00 [received] PHST- 2023/10/20 00:00 [revised] PHST- 2023/11/01 00:00 [accepted] PHST- 2023/11/25 12:46 [medline] PHST- 2023/11/25 12:45 [pubmed] PHST- 2023/11/25 01:25 [entrez] PHST- 2023/11/07 00:00 [pmc-release] AID - ma16227074 [pii] AID - materials-16-07074 [pii] AID - 10.3390/ma16227074 [doi] PST - epublish SO - Materials (Basel). 2023 Nov 7;16(22):7074. doi: 10.3390/ma16227074. PMID- 39361699 OWN - NLM STAT- MEDLINE DCOM- 20241003 LR - 20241003 IS - 1545-9616 (Print) IS - 1545-9616 (Linking) VI - 23 IP - 10 DP - 2024 Oct 1 TI - INDIVIDUAL ARTCLE: Pathophysiologic Targets of Acne Treatment. PG - 54122s4-54122s11 AB - Acne vulgaris is an extremely common dermatologic condition. Individuals with acne present not only to dermatologists, but also to internists, family medicine physicians, pediatricians, estheticians, and beauty counters alike in search of a treatment. The diagnosis of acne is relatively straightforward, leading many to believe that acne is a simple condition. However, the pathophysiology of acne is anything but simple. Decades of research has ultimately revealed a complex interaction of pathogenic factors that lead to acne. This includes sebum production, C. acnes colonization, inflammation, and follicular hyperkeratinization. Understanding each of these features has been fundamental to the development of anti-acne medications. Topical agents are often used as an initial therapy given their safety and efficacy. While some topical therapies have been used for decades, new creams, gels, and lotions continue to be added to the list of approved acne treatments. Given the number of topical acne products on the market, we present an updated review of the current landscape of topical acne treatments and how each choice functions mechanistically to fight against acne. J Drugs Dermatol. 2024;23:10(Suppl 1):s4-11. FAU - Graber, Emmy M AU - Graber EM FAU - Vincent, Natalie AU - Vincent N LA - eng PT - Journal Article PT - Review PL - United States TA - J Drugs Dermatol JT - Journal of drugs in dermatology : JDD JID - 101160020 RN - 0 (Dermatologic Agents) SB - IM MH - *Acne Vulgaris/drug therapy MH - Humans MH - *Dermatologic Agents/administration & dosage/therapeutic use MH - *Administration, Cutaneous MH - Propionibacterium acnes/drug effects/isolation & purification MH - Sebum/metabolism EDAT- 2024/10/04 07:19 MHDA- 2024/10/04 07:20 CRDT- 2024/10/03 13:51 PHST- 2024/10/04 07:20 [medline] PHST- 2024/10/04 07:19 [pubmed] PHST- 2024/10/03 13:51 [entrez] AID - S1545961624S54122X [pii] PST - ppublish SO - J Drugs Dermatol. 2024 Oct 1;23(10):54122s4-54122s11. PMID- 22954378 OWN - NLM STAT- MEDLINE DCOM- 20130317 LR - 20211021 IS - 1744-764X (Electronic) IS - 1474-0338 (Print) IS - 1474-0338 (Linking) VI - 11 IP - 6 DP - 2012 Nov TI - Safety and efficacy of immunomodulators and biologics during pregnancy and lactation for the treatment of inflammatory bowel disease. PG - 947-57 LID - 10.1517/14740338.2012.720970 [doi] AB - INTRODUCTION: The inflammatory bowel diseases (IBD) are chronic, idiopathic, inflammatory conditions of the gastrointestinal tract, that peak in incidence during the reproductive years. Therefore, the safety of IBD medications during pregnancy and lactation is of significant interest to patients. Unfortunately, the current pregnancy labeling used by the United States Food and Drug Association (FDA) is often misinterpreted and may mislead healthcare providers and their patients to believe that risk increases from Category A to B to C to D to X, which in fact, is not the case. In addition, the FDA categories do not always distinguish between risks based on human versus animal data, or between differences in frequency, severity, and type of fetal developmental toxicities. AREAS COVERED: This article provides an in-depth review of the available safety data during pregnancy and lactation for the more potent immunosuppressants used to treat IBD: the immunomodulators and biologics. It also includes the authors' expert opinions on the use of these medications during these critical periods. EXPERT OPINION: The benefit-to-risk ratio for most immunomodulators and biologics used in the treatment of IBD favors medication continuation during pregnancy. Certain immunomodulators, however, can cause extreme fetal harm and should be used with caution. While human safety data regarding teratogenesis and some data on pregnancy outcomes exist for most IBD medications, long-term follow-up studies of children and young adults exposed to these drugs in utero are lacking. These studies are needed to determine if these drugs are of sufficiently low risk to be considered safe. FAU - Saha, Sumona AU - Saha S AD - University of Wisconsin, School of Medicine and Public Health, 1685 Highland Avenue, Madison, 53705, USA. FAU - Wald, Arnold AU - Wald A LA - eng GR - K12 HD055894/HD/NICHD NIH HHS/United States GR - K12HD055894/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review DEP - 20120906 PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - 0 (Immunologic Factors) SB - IM MH - Animals MH - Drug Labeling MH - Female MH - Humans MH - Immunologic Factors/adverse effects/*therapeutic use MH - Inflammatory Bowel Diseases/complications/*drug therapy MH - *Lactation MH - Pregnancy MH - Pregnancy Complications/*drug therapy/physiopathology MH - Pregnancy Outcome MH - Risk MH - United States MH - United States Food and Drug Administration PMC - PMC3703756 MID - NIHMS474773 COIS- DECLARATION OF INTEREST The authors state no conflict of interest with regards to this manuscript. EDAT- 2012/09/08 06:00 MHDA- 2013/03/19 06:00 PMCR- 2013/07/08 CRDT- 2012/09/08 06:00 PHST- 2012/09/08 06:00 [entrez] PHST- 2012/09/08 06:00 [pubmed] PHST- 2013/03/19 06:00 [medline] PHST- 2013/07/08 00:00 [pmc-release] AID - 10.1517/14740338.2012.720970 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2012 Nov;11(6):947-57. doi: 10.1517/14740338.2012.720970. Epub 2012 Sep 6. PMID- 28760830 OWN - NLM STAT- MEDLINE DCOM- 20180514 LR - 20180706 IS - 1477-9145 (Electronic) IS - 0022-0949 (Linking) VI - 220 IP - Pt 19 DP - 2017 Oct 1 TI - Chronic warm exposure impairs growth performance and reduces thermal safety margins in the common triplefin fish (Forsterygion lapillum). PG - 3527-3535 LID - 10.1242/jeb.162099 [doi] AB - Intertidal fish species face gradual chronic changes in temperature and greater extremes of acute thermal exposure through climate-induced warming. As sea temperatures rise, it has been proposed that whole-animal performance will be impaired through oxygen and capacity limited thermal tolerance [OCLTT; reduced aerobic metabolic scope (MS)] and, on acute exposure to high temperatures, thermal safety margins may be reduced because of constrained acclimation capacity of upper thermal limits. Using the New Zealand triplefin fish (Forsterygion lapillum), this study addressed how performance in terms of growth and metabolism (MS) and upper thermal tolerance limits would be affected by chronic exposure to elevated temperature. Growth was measured in fish acclimated (12 weeks) to present and predicted future temperatures and metabolic rates were then determined in fish at acclimation temperatures and with acute thermal ramping. In agreement with the OCLTT hypothesis, chronic exposure to elevated temperature significantly reduced growth performance and MS. However, despite the prospect of impaired growth performance under warmer future summertime conditions, an annual growth model revealed that elevated temperatures may only shift the timing of high growth potential and not the overall annual growth rate. While the upper thermal tolerance (i.e. critical thermal maxima) increased with exposure to warmer temperatures and was associated with depressed metabolic rates during acute thermal ramping, upper thermal tolerance did not differ between present and predicted future summertime temperatures. This suggests that warming may progressively decrease thermal safety margins for hardy generalist species and could limit the available habitat range of intertidal populations. CI - © 2017. Published by The Company of Biologists Ltd. FAU - McArley, Tristan J AU - McArley TJ AUID- ORCID: 0000-0002-5248-2828 AD - Institute of Marine Science, University of Auckland, Leigh, Warkworth 0941, New Zealand tmca008@aucklanduni.ac.nz. FAU - Hickey, Anthony J R AU - Hickey AJR AD - School of Biological Sciences, University of Auckland, 3a Symonds Street, Thomas Building, Auckland 1010, New Zealand. FAU - Herbert, Neill A AU - Herbert NA AD - Institute of Marine Science, University of Auckland, Leigh, Warkworth 0941, New Zealand. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170731 PL - England TA - J Exp Biol JT - The Journal of experimental biology JID - 0243705 SB - IM MH - Animals MH - *Basal Metabolism MH - *Hot Temperature MH - New Zealand MH - *Oxygen Consumption MH - Perciformes/growth & development/*physiology MH - Random Allocation MH - *Thermotolerance OTO - NOTNLM OT - Climate change OT - Metabolic scope OT - OCLTT OT - Oxygen and capacity limited thermal tolerance OT - Respirometry OT - Thermal tolerance COIS- Competing interestsThe authors declare no competing or financial interests. EDAT- 2017/08/02 06:00 MHDA- 2018/05/15 06:00 CRDT- 2017/08/02 06:00 PHST- 2017/05/01 00:00 [received] PHST- 2017/07/25 00:00 [accepted] PHST- 2017/08/02 06:00 [pubmed] PHST- 2018/05/15 06:00 [medline] PHST- 2017/08/02 06:00 [entrez] AID - jeb.162099 [pii] AID - 10.1242/jeb.162099 [doi] PST - ppublish SO - J Exp Biol. 2017 Oct 1;220(Pt 19):3527-3535. doi: 10.1242/jeb.162099. Epub 2017 Jul 31. PMID- 22222111 OWN - NLM STAT- MEDLINE DCOM- 20120531 LR - 20211021 IS - 1475-2859 (Electronic) IS - 1475-2859 (Linking) VI - 11 DP - 2012 Jan 5 TI - The new pLAI (lux regulon based auto-inducible) expression system for recombinant protein production in Escherichia coli. PG - 3 LID - 10.1186/1475-2859-11-3 [doi] AB - BACKGROUND: After many years of intensive research, it is generally assumed that no universal expression system can exist for high-level production of a given recombinant protein. Among the different expression systems, the inducible systems are the most popular for their tight regulation. However, induction is in many cases less favorable due to the high cost and/or toxicity of inducers, incompatibilities with industrial scale-up or detrimental growth conditions. Expression systems using autoinduction (or self-induction) prove to be extremely versatile allowing growth and induction of recombinant proteins without the need to monitor cell density or add inducer. Unfortunately, almost all the actual auto inducible expression systems need endogenous or induced metabolic changes during the growth to trigger induction, both frequently linked to detrimental condition to cell growth. In this context, we use a simple modular approach for a cell density-based genetic regulation in order to assemble an autoinducible recombinant protein expression system in E. coli. RESULT: The newly designed pLAI expression system places the expression of recombinant proteins in Escherichia coli under control of the regulatory genes of the lux regulon of Vibrio fischeri's Quorum Sensing (QS) system.The pLAI system allows a tight regulation of the recombinant gene allowing a negligible basal expression and expression only at high cell density. Sequence optimization of regulative genes of QS of V. fischeri for expression in E. coli upgraded the system to high level expression. Moreover, partition of regulative genes between the plasmid and the host genome and introduction of a molecular safety lock permitted tighter control of gene expression. CONCLUSION: Coupling gene expression to cell density using cell-to-cell communication provides a promising approach for recombinant protein production. The system allows the control of expression of the target recombinant gene independently from external inducers or drastic changes in metabolic conditions and enabling tight regulation of expression. FAU - Nocadello, Salvatore AU - Nocadello S AD - Novartis Vaccines and Diagnostics srl, 53100 Siena, Italy. nocadellosalvatore@gmail.com FAU - Swennen, Erwin Frans AU - Swennen EF LA - eng PT - Journal Article DEP - 20120105 PL - England TA - Microb Cell Fact JT - Microbial cell factories JID - 101139812 RN - 0 (Bacterial Proteins) RN - 0 (LuxI protein, Bacteria) RN - 0 (QsrP protein, Vibrio fischeri) RN - 0 (Recombinant Proteins) RN - 0 (Repressor Proteins) RN - 0 (Trans-Activators) RN - 0 (Transcription Factors) RN - 115038-68-1 (LuxR autoinducer binding proteins) SB - IM MH - Aliivibrio fischeri/genetics MH - Bacterial Proteins/*genetics/metabolism MH - Escherichia coli/genetics/*metabolism MH - *Genetic Vectors MH - Promoter Regions, Genetic MH - Recombinant Proteins/*biosynthesis/genetics MH - Repressor Proteins/*genetics MH - Trans-Activators/*genetics MH - Transcription Factors/genetics PMC - PMC3274441 EDAT- 2012/01/10 06:00 MHDA- 2012/06/01 06:00 PMCR- 2012/01/05 CRDT- 2012/01/07 06:00 PHST- 2011/09/14 00:00 [received] PHST- 2012/01/05 00:00 [accepted] PHST- 2012/01/07 06:00 [entrez] PHST- 2012/01/10 06:00 [pubmed] PHST- 2012/06/01 06:00 [medline] PHST- 2012/01/05 00:00 [pmc-release] AID - 1475-2859-11-3 [pii] AID - 10.1186/1475-2859-11-3 [doi] PST - epublish SO - Microb Cell Fact. 2012 Jan 5;11:3. doi: 10.1186/1475-2859-11-3. PMID- 36634694 OWN - NLM STAT- MEDLINE DCOM- 20230224 LR - 20241219 IS - 2352-4650 (Electronic) IS - 2352-4642 (Print) IS - 2352-4642 (Linking) VI - 7 IP - 3 DP - 2023 Mar TI - Efficacy of nirsevimab against respiratory syncytial virus lower respiratory tract infections in preterm and term infants, and pharmacokinetic extrapolation to infants with congenital heart disease and chronic lung disease: a pooled analysis of randomised controlled trials. PG - 180-189 LID - S2352-4642(22)00321-2 [pii] LID - 10.1016/S2352-4642(22)00321-2 [doi] AB - BACKGROUND: In a phase 2b trial and the phase 3 MELODY trial, nirsevimab, an extended half-life, monoclonal antibody against respiratory syncytial virus (RSV), protected healthy infants born preterm or at full term against medically attended RSV lower respiratory tract infection (LRTI). In the MEDLEY phase 2-3 trial in infants at higher risk for severe RSV infection, nirsevimab showed a similar safety profile to that of palivizumab. The aim of the current analysis was to assess the efficacy of nirsevimab using a weight-banded dosing regimen in infants born between 29 weeks gestational age and full term. METHODS: Infants enrolled in the phase 2b and MELODY trials were randomised (2:1) to receive a single intramuscular injection of nirsevimab (infants weighing <5 kg received 50 mg; those weighing ≥5 kg received 100 mg) or placebo before the RSV season. Infants in MEDLEY were randomised (2:1) to receive one dose of nirsevimab (infants weighing <5 kg received 50 mg; those weighing ≥5 kg received 100 mg) followed by four monthly placebo doses, or five once-a-month intramuscular doses of palivizumab. We report a prespecified pooled efficacy analysis assessing the weight-banded dosing regimen proposed on the basis of the phase 2b and MELODY trials, in addition to extrapolated efficacy in infants with chronic lung disease, congenital heart disease, or extreme preterm birth (<29 weeks' gestational age) based on pharmacokinetic data from the phase 2-3 MEDLEY safety trial. For the pooled efficacy analysis, the primary endpoint was incidence of medically attended RSV LRTI through 150 days post-dose. The secondary efficacy endpoint was number of admissions to hospital for medically attended RSV LRTI. The incidence of very severe RSV LRTI was an exploratory endpoint, defined as cases of hospital admission for medically attended RSV LRTI that required supplemental oxygen or intravenous fluids. We also did a prespecified exploratory analysis of medically attended LRTI of any cause (in the investigator's judgement) and hospital admission for respiratory illness of any cause (defined as any upper respiratory tract infection or LRTI leading to hospital admission). Post hoc exploratory analyses of outpatient visits and antibiotic use were also done. Nirsevimab serum concentrations in MEDLEY were assessed using population pharmacokinetic methods and the pooled data from the phase 2b and MELODY trials. An exposure target was defined on the basis of an exposure-response analysis. To successfully demonstrate extrapolation, more than 80% of infants in MEDLEY had to achieve serum nirsevimab exposures at or above the predicted efficacious target. FINDINGS: Overall, 2350 infants (1564 in the nirsevimab group and 786 in the placebo group) in the phase 2b and MELODY trials were included in the pooled analysis. Nirsevimab showed efficacy versus placebo with respect to the primary endpoint of medically attended RSV LRTI (19 [1%] nirsevimab recipients vs 51 [6%] placebo recipients; relative risk reduction [RRR] 79·5% [95% CI 65·9-87·7]). Consistent efficacy was shown for additional endpoints of RSV LRTI hospital admission (nine [1%] nirsevimab recipients vs 21 [3%] placebo recipients; 77·3% [50·3-89·7]) and very severe RSV (five [<1%] vs 18 [2%]; 86·0% [62·5-94·8]). Nirsevimab recipients had fewer hospital admissions for any-cause respiratory illness (RRR 43·8% [18·8-61·1]), any-cause medically attended LRTI (35·4% [21·5-46·9]), LRTI outpatient visits (41·9% [25·7-54·6]), and antibiotic prescriptions (23·6% [3·8-39·3]). Among infants with chronic lung disease, congenital heart disease, or extreme preterm birth in MEDLEY, nirsevimab serum exposures were similar to those found in the pooled data; exposures were above the target in more than 80% of the overall MEDLEY trial population (94%), including infants with chronic lung disease (94%) or congenital heart disease (80%) and those born extremely preterm (94%). INTERPRETATION: A single dose of nirsevimab protected healthy infants born at term or preterm from medically attended RSV LRTI, associated hospital admission, and severe RSV. Pharmacokinetic data support efficacy extrapolation to infants with chronic lung disease, congenital heart disease, or extreme prematurity. Together, these data suggest that nirsevimab has the potential to change the landscape of infant RSV disease by reducing a major cause of infant morbidity and the consequent burden on caregivers, clinicians, and health-care providers. FUNDING: AstraZeneca and Sanofi. CI - Copyright © 2023 Elsevier Ltd. All rights reserved. FAU - Simões, Eric A F AU - Simões EAF AD - Children's Hospital Colorado, Aurora, CO, USA. FAU - Madhi, Shabir A AU - Madhi SA AD - South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Muller, William J AU - Muller WJ AD - Ann & Robert H Lurie Children's Hospital of Chicago and Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Atanasova, Victoria AU - Atanasova V AD - Dr Georgi Stranski University Hospital, Pleven, Bulgaria. FAU - Bosheva, Miroslava AU - Bosheva M AD - University Multiprofile Hospital for Active Treatment Sv Georgi Medical University, Plovdiv, Bulgaria. FAU - Cabañas, Fernando AU - Cabañas F AD - Quironsalud Madrid University Hospital, Madrid, Spain. FAU - Baca Cots, Manuel AU - Baca Cots M AD - Quirónsalud Málaga Hospital, Malaga, Spain. FAU - Domachowske, Joseph B AU - Domachowske JB AD - State University of New York Upstate Medical University, Syracuse, NY, USA. FAU - Garcia-Garcia, Maria L AU - Garcia-Garcia ML AD - University Hospital Severo Ochoa, Madrid, Spain. FAU - Grantina, Ineta AU - Grantina I AD - Bērnu Klīniskā Universitātes Slimnīca, Riga, Latvia. FAU - Nguyen, Kim A AU - Nguyen KA AD - Hospices Civils de Lyon, Neonatal Intensive Care Units and CIC 1407, Lyon, France. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics and Child Health, Red Cross Children's Hospital, Cape Town, South Africa; SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Berglind, Anna AU - Berglind A AD - Biometrics, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. FAU - Cummings, Celeste AU - Cummings C AD - Clinical Development, Vaccines & Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Durham, NC, USA. FAU - Griffin, M Pamela AU - Griffin MP AD - Clinical Development, Vaccines & Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. FAU - Takas, Therese AU - Takas T AD - Clinical Development, Vaccines & Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. FAU - Yuan, Yuan AU - Yuan Y AD - Biometrics, Vaccines & Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. FAU - Wählby Hamrén, Ulrika AU - Wählby Hamrén U AD - Clinical Pharmacology and Quantitative Pharmacology, R&D, AstraZeneca, Gothenburg, Sweden. FAU - Leach, Amanda AU - Leach A AD - Clinical Development, Vaccines & Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. FAU - Villafana, Tonya AU - Villafana T AD - Clinical Development, Vaccines & Immune Therapies, Biopharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA. Electronic address: tonya.villafana@astrazeneca.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230109 PL - England TA - Lancet Child Adolesc Health JT - The Lancet. Child & adolescent health JID - 101712925 RN - VRN8S9CW5V (nirsevimab) RN - DQ448MW7KS (Palivizumab) RN - 0 (Antiviral Agents) SB - IM CIN - Lancet Child Adolesc Health. 2023 Mar;7(3):147-149. doi: 10.1016/S2352-4642(22)00377-7. PMID: 36634693 CIN - Transl Pediatr. 2024 Mar 27;13(3):525-529. doi: 10.21037/tp-23-534. PMID: 38590379 MH - Female MH - Infant MH - Infant, Newborn MH - Humans MH - Palivizumab/therapeutic use MH - *Premature Birth MH - Antiviral Agents/therapeutic use MH - *Respiratory Syncytial Virus Infections/epidemiology MH - *Respiratory Syncytial Virus, Human MH - *Respiratory Tract Infections/epidemiology MH - *Heart Defects, Congenital MH - *Lung Diseases MH - Randomized Controlled Trials as Topic PMC - PMC9940918 COIS- Declaration of interests EAFS has received grants or contracts from AstraZeneca, Johnson and Johnson, Merck, Pfizer, and Roche; consulting fees from Adiago Therapeutics, Cidara Therapeutics, Merck, Nuance Pharmaceuticals, Pfizer, and Sanofi; payment or honoraria from AstraZeneca and Pfizer; support for meeting attendance and/or travel from AstraZeneca; and has participated in data safety monitoring boards or advisory boards for Abbvie, the Bill and Melinda Gates Foundation, and GSK. SAM has received grants or contracts from the Bill and Melinda Gates Foundation, GSK, Minervax, Pfizer, and the South African Medical Research Council; payments or honoraria from the Bill and Melinda Gates Foundation; and has participated in data safety monitoring boards or advisory boards for PATH and CAPRISA. WJM has received grants or contracts from Ansun, Astellas, AstraZeneca, Eli Lilly, Enanta Pharmaceuticals, Genentech, Gilead, Janssen, Karius, Melinta, Merck, Moderna, Nabriva, Paratek, Pfizer, and Tetraphase; consulting fees from Finley Law Firm and Seqirus; payment or honoraria from Contemporary Pediatrics; and has participated in data safety monitoring boards or advisory boards for Adagio Therapeutics and ProventionBio. FC is a member of the Paediatric Committee at the European Medicines Agency (EMA), but has not participated in the deliberations or decisions related to this product (as communicated to the EMA). JBD has received consulting fees from Sanofi; payment or honoraria from Sanofi; and has participated in data safety monitoring boards or advisory boards for AstraZeneca. HJZ has received grants or contracts from AstraZeneca, MSD, and Pfizer; payment or honoraria from Sanofi; and has participated in data safety monitoring boards or advisory boards for Pfizer. AB, CC, MPG, TT, UWH, AL, and TV are employees of and hold stock or stock options in AstraZeneca. YY is a former employee of and holds stock or stock options in AstraZeneca. All other authors declare no competing interests. EDAT- 2023/01/13 06:00 MHDA- 2023/02/25 06:00 PMCR- 2023/01/09 CRDT- 2023/01/12 18:53 PHST- 2022/08/27 00:00 [received] PHST- 2022/11/01 00:00 [revised] PHST- 2022/11/02 00:00 [accepted] PHST- 2023/01/13 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2023/01/12 18:53 [entrez] PHST- 2023/01/09 00:00 [pmc-release] AID - S2352-4642(22)00321-2 [pii] AID - 10.1016/S2352-4642(22)00321-2 [doi] PST - ppublish SO - Lancet Child Adolesc Health. 2023 Mar;7(3):180-189. doi: 10.1016/S2352-4642(22)00321-2. Epub 2023 Jan 9. PMID- 10783378 OWN - NLM STAT- MEDLINE DCOM- 20000720 LR - 20190513 IS - 0268-1161 (Print) IS - 0268-1161 (Linking) VI - 15 IP - 5 DP - 2000 May TI - Posterior uterine wall rupture during labour. PG - 1198-9 AB - Vaginal births after Caesarean section (VBAC) are well-accepted procedures when pregnant women do not have any contra-indications. The possibilities of the uterine dehisence and rupture during VBAC should always be considered. This occurrence is usually related to the previous scar tissue and subsequent risk is acceptable. Nevertheless, rupture that occurs in presumably normal tissue areas of the uterus instead of in scar tissue areas with resultant perinatal death is extremely rare. We present a 31 year old woman who had posterior uterine rupture when she tried VBAC at 38 weeks gestation. During the course of VBAC, she had a smooth labour course without use of any augmentation medication, but her condition was complicated with uterine rupture without any premonitory signal. It resulted in maternal shock and sequentially the death of the newborn 7 days after delivery. By reviewing this case report, we should keep in mind that prompt response to every woman during labour is of paramount importance to avoid repeating the occurrence of uterine rupture, partly because uterine rupture could occur without prominent signals and partly because subsequent dangers seem to be those created by acts of omission. Finally, the benefits and safety of VBAC have not been undermined because this patient is an isolated and extremely rare case. FAU - Wang, P H AU - Wang PH AD - Department of Obstetrics and Gynecology, Veterans General Hospital-Taipei, Taipei 11217, Taiwan. FAU - Yuan, C C AU - Yuan CC FAU - Chao, H T AU - Chao HT FAU - Yang, M J AU - Yang MJ FAU - Ng, H T AU - Ng HT LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Hum Reprod JT - Human reproduction (Oxford, England) JID - 8701199 SB - IM MH - Abdomen/*surgery MH - Adult MH - Female MH - Fetal Death MH - Humans MH - Pregnancy MH - *Uterine Rupture MH - *Vaginal Birth after Cesarean EDAT- 2000/04/28 09:00 MHDA- 2000/07/25 11:00 CRDT- 2000/04/28 09:00 PHST- 2000/04/28 09:00 [pubmed] PHST- 2000/07/25 11:00 [medline] PHST- 2000/04/28 09:00 [entrez] AID - 10.1093/humrep/15.5.1198 [doi] PST - ppublish SO - Hum Reprod. 2000 May;15(5):1198-9. doi: 10.1093/humrep/15.5.1198. PMID- 39749527 OWN - NLM STAT- Publisher LR - 20250103 IS - 1549-7852 (Electronic) IS - 1040-8398 (Linking) DP - 2025 Jan 3 TI - Mechanisms of thermal, acid, desiccation and osmotic tolerance of Cronobacter spp. PG - 1-23 LID - 10.1080/10408398.2024.2447304 [doi] AB - Cronobacter spp. exhibit remarkable resilience to extreme environmental stresses, including thermal, acidic, desiccation, and osmotic conditions, posing significant challenges to food safety. Their thermotolerance relies on heat shock proteins (HSPs), thermotolerance genomic islands, enhanced DNA repair mechanisms, and metabolic adjustments, ensuring survival under high-temperature conditions. Acid tolerance is achieved through internal pH regulation, acid efflux pumps, and acid tolerance proteins, allowing survival in acidic food matrices and the gastrointestinal tract. Desiccation tolerance is mediated by the accumulation of protective osmolytes like trehalose, stabilizing proteins and membranes to withstand dryness, especially in dry food products. Similarly, osmotic stress resilience is supported by compatible solutes such as trehalose and glycine betaine, along with metabolic adaptations to balance osmotic pressures. These mechanisms highlight the adaptability of Cronobacter spp. to diverse environments. Moreover, exposure to sublethal stresses, including heat, osmotic, dry, and pH stresses, may induce homologous or cross-resistance, complicating control strategies. Understanding these survival mechanisms is essential to mitigate the risks of Cronobacter spp., especially in powdered infant formula (PIF), and ensure food safety. FAU - Yan, Yanfei AU - Yan Y AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Cao, Mengyuan AU - Cao M AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Ma, Jiaqi AU - Ma J AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Suo, Jia AU - Suo J AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Bai, Xiaobao AU - Bai X AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Ge, Wupeng AU - Ge W AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Lü, Xin AU - Lü X AUID- ORCID: 0000-0002-8624-0464 AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Zhang, Qiang AU - Zhang Q AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. FAU - Chen, Jia AU - Chen J AD - College of Chemical Technology, Shijiazhuang University, Shijiazhuang, China. FAU - Cui, Shenghui AU - Cui S AD - National Institutes for Food and Drug Control, Beijing, China. FAU - Yang, Baowei AU - Yang B AD - College of Food Science and Engineering, Northwest A&F University, Yangling, China. LA - eng PT - Journal Article PT - Review DEP - 20250103 PL - United States TA - Crit Rev Food Sci Nutr JT - Critical reviews in food science and nutrition JID - 8914818 SB - IM OTO - NOTNLM OT - Cronobacter spp., environmental stress OT - acid tolerance OT - desiccation OT - osmotic stress OT - thermal tolerance EDAT- 2025/01/03 06:21 MHDA- 2025/01/03 06:21 CRDT- 2025/01/03 05:05 PHST- 2025/01/03 06:21 [medline] PHST- 2025/01/03 06:21 [pubmed] PHST- 2025/01/03 05:05 [entrez] AID - 10.1080/10408398.2024.2447304 [doi] PST - aheadofprint SO - Crit Rev Food Sci Nutr. 2025 Jan 3:1-23. doi: 10.1080/10408398.2024.2447304. PMID- 33153693 OWN - NLM STAT- MEDLINE DCOM- 20210212 LR - 20220507 IS - 1557-8216 (Electronic) IS - 0272-5231 (Print) IS - 0272-5231 (Linking) VI - 41 IP - 4 DP - 2020 Dec TI - Working in Smoke:: Wildfire Impacts on the Health of Firefighters and Outdoor Workers and Mitigation Strategies. PG - 763-769 LID - S0272-5231(20)30092-7 [pii] LID - 10.1016/j.ccm.2020.08.017 [doi] AB - Wildland firefighters work on wildfire incidents all over the United States and perform arduous work under extreme work conditions, including exposure to smoke. Wildland fire smoke is a mixture of hazardous air pollutants. For assessing wildland firefighter exposure to smoke, most studies measured carbon monoixde (CO) and particulate matter and reported changes in lung health by measured lung function, airway responsiveness, and respiratory symptoms across individual work shifts and single fire seasons. All fire personnel should understand the hazards of smoke and develop ways to mitigate exposure to smoke. CI - Published by Elsevier Inc. FAU - Navarro, Kathleen AU - Navarro K AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Avenue MS 13, Cincinnati, OH, USA. Electronic address: knavarro@cdc.gov. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States PT - Journal Article PT - Review PL - United States TA - Clin Chest Med JT - Clinics in chest medicine JID - 7907612 SB - IM MH - Firefighters MH - Humans MH - Occupational Exposure/*adverse effects MH - Smoke Inhalation Injury/*etiology MH - Wildfires/*mortality PMC - PMC9008597 MID - NIHMS1793760 OTO - NOTNLM OT - Firefighters OT - Outdoor workers OT - Particulate matter OT - Smoke OT - Wildfire EDAT- 2020/11/07 06:00 MHDA- 2021/02/13 06:00 PMCR- 2022/04/14 CRDT- 2020/11/06 05:40 PHST- 2020/11/06 05:40 [entrez] PHST- 2020/11/07 06:00 [pubmed] PHST- 2021/02/13 06:00 [medline] PHST- 2022/04/14 00:00 [pmc-release] AID - S0272-5231(20)30092-7 [pii] AID - 10.1016/j.ccm.2020.08.017 [doi] PST - ppublish SO - Clin Chest Med. 2020 Dec;41(4):763-769. doi: 10.1016/j.ccm.2020.08.017. PMID- 38635166 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240712 IS - 1521-4095 (Electronic) IS - 0935-9648 (Linking) VI - 36 IP - 28 DP - 2024 Jul TI - Challenges and Breakthroughs in Enhancing Temperature Tolerance of Sodium-Ion Batteries. PG - e2402291 LID - 10.1002/adma.202402291 [doi] AB - Lithium-based batteries (LBBs) have been highly researched and recognized as a mature electrochemical energy storage (EES) system in recent years. However, their stability and effectiveness are primarily confined to room temperature conditions. At temperatures significantly below 0 °C or above 60 °C, LBBs experience substantial performance degradation. Under such challenging extreme contexts, sodium-ion batteries (SIBs) emerge as a promising complementary technology, distinguished by their fast dynamics at low-temperature regions and superior safety under elevated temperatures. Notably, developing SIBs suitable for wide-temperature usage still presents significant challenges, particularly for specific applications such as electric vehicles, renewable energy storage, and deep-space/polar explorations, which requires a thorough understanding of how SIBs perform under different temperature conditions. By reviewing the development of wide-temperature SIBs, the influence of temperature on the parameters related to battery performance, such as reaction constant, charge transfer resistance, etc., is systematically and comprehensively analyzed. The review emphasizes challenges encountered by SIBs in both low and high temperatures while exploring recent advancements in SIB materials, specifically focusing on strategies to enhance battery performance across diverse temperature ranges. Overall, insights gained from these studies will drive the development of SIBs that can handle the challenges posed by diverse and harsh climates. CI - © 2024 Wiley‐VCH GmbH. FAU - Che, Chang AU - Che C AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. FAU - Wu, Feng AU - Wu F AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. AD - Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314019, P. R. China. FAU - Li, Yu AU - Li Y AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. FAU - Li, Ying AU - Li Y AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. AD - Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314019, P. R. China. FAU - Li, Shuqiang AU - Li S AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. FAU - Wu, Chuan AU - Wu C AUID- ORCID: 0000-0003-3878-179X AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. AD - Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314019, P. R. China. FAU - Bai, Ying AU - Bai Y AD - Beijing Key Laboratory of Environmental Science and Engineering, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. AD - Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing, 314019, P. R. China. LA - eng GR - 22279009/National Natural Science Foundation of China/ GR - 22005033/National Natural Science Foundation of China/ GR - 22379015/National Natural Science Foundation of China/ GR - XSQD-202108005/Beijing Institute of Technology Research Fund Program for Young Scholars/ PT - Journal Article PT - Review DEP - 20240506 PL - Germany TA - Adv Mater JT - Advanced materials (Deerfield Beach, Fla.) JID - 9885358 SB - IM OTO - NOTNLM OT - extreme environment OT - sodium‐ion batteries OT - temperature effect OT - wide‐temperature EDAT- 2024/04/18 12:44 MHDA- 2024/04/18 12:45 CRDT- 2024/04/18 11:23 PHST- 2024/03/21 00:00 [revised] PHST- 2024/02/13 00:00 [received] PHST- 2024/04/18 12:45 [medline] PHST- 2024/04/18 12:44 [pubmed] PHST- 2024/04/18 11:23 [entrez] AID - 10.1002/adma.202402291 [doi] PST - ppublish SO - Adv Mater. 2024 Jul;36(28):e2402291. doi: 10.1002/adma.202402291. Epub 2024 May 6. PMID- 39936601 OWN - NLM STAT- Publisher LR - 20250212 IS - 1465-3621 (Electronic) IS - 0368-2811 (Linking) DP - 2025 Feb 12 TI - Diagnosis, clinical characteristics, and treatment of combined hepatocellular-cholangiocarcinoma. LID - hyaf029 [pii] LID - 10.1093/jjco/hyaf029 [doi] AB - The concept and definition of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), an extremely rare condition accounting for only 1% of all primary liver cancers, has shifted in recent years. The latest World Health Organization Classification (fifth edition) includes two types of cHCC-CCAs, (i) the classical type described in the previous edition, which contains a mixture of distinctly differentiated components of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) and (ii) intermediate cell carcinoma wherein all cells comprising the tumor express both hepatocellular and cholangiocellular features. However, the pathogenesis of cHCC-CCA, including its origins, remains controversial even among experts. Treatment strategies for cHCC-CCA in clinical practice have been determined based on imaging findings, tumor markers, and pathologically predominant tumor components for either HCC or ICC, suggesting that cHCC-CCA has yet to be been established as an independent disease entity. As with HCC and ICC, the treatment strategy for HCC-CCA involves initially considering resectability. Although systemic therapy has been considered for patients unsuitable for local treatment, no prospective clinical trials have evaluated the efficacy and safety of systemic therapy for cHCC-CCA, which could explain the lack of a standard of care. In recent years, however, studies have demonstrated the efficacy of immune checkpoint inhibitors for HCC and ICC, with therapeutic results having been reported for cHCC-CCA. Hence, further accumulation of cases is expected to facilitate the establishment of a consensus on treatment strategies in the near future. CI - © The Author(s) 2025. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Terashima, Takeshi AU - Terashima T AUID- ORCID: 0000-0002-1052-0101 AD - Department of Gastroenterology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. FAU - Harada, Kenichi AU - Harada K AD - Department of Human Pathology, Kanazawa University Graduate School of Medical Sciences, 13-1, Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. FAU - Yamashita, Taro AU - Yamashita T AD - Department of Gastroenterology, Kanazawa University Hospital, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan. LA - eng PT - Journal Article DEP - 20250212 PL - England TA - Jpn J Clin Oncol JT - Japanese journal of clinical oncology JID - 0313225 SB - IM OTO - NOTNLM OT - combined hepatocellular-cholangiocarcinoma OT - immunotherapy OT - systemic therapy EDAT- 2025/02/12 12:26 MHDA- 2025/02/12 12:26 CRDT- 2025/02/12 07:43 PHST- 2024/12/05 00:00 [received] PHST- 2025/01/28 00:00 [accepted] PHST- 2025/02/12 12:26 [medline] PHST- 2025/02/12 12:26 [pubmed] PHST- 2025/02/12 07:43 [entrez] AID - 8010270 [pii] AID - 10.1093/jjco/hyaf029 [doi] PST - aheadofprint SO - Jpn J Clin Oncol. 2025 Feb 12:hyaf029. doi: 10.1093/jjco/hyaf029. PMID- 31764803 OWN - NLM STAT- MEDLINE DCOM- 20191206 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 98 IP - 47 DP - 2019 Nov TI - Predictor of sleep difficulty among community dwelling older populations in 2 African settings. PG - e17971 LID - 10.1097/MD.0000000000017971 [doi] LID - e17971 AB - Sleep deprivation is a common phenomenon among older population and is commonly linked to behavioral, physiological, and psychosocial factors. Not much is known about sleep deprivation among older population in Africa. Therefore, in this study we aimed to investigate the basic sociodemographic and psychosocial predictors of self-reported sleep deprivation among older population.In this study we analyzed cross-sectional data on 1495 community dwelling men and women aged 50 years and above. Data were collected from the SAGE Well-Being of Older People Study conducted in South Africa and Uganda. Outcome variable was self-reported sleep difficulty last 30 days. Multivariable logistic regression models were used to identify the variables significantly associated with sleep difficulty.The prevalence of mild-moderate sleep difficulty was 32.6% (27.9, 37.6) and severe/extreme 23.0% (20.3, 26.0) respectively. Multivariable analysis revealed that sleep difficulty was associated with several behavioral, environment, and illness conditions. In South Africa, those who reported dissatisfaction with living condition had 1.592 [1.087, 2.787] times higher odds of reporting mild/moderate sleep difficulty. Poor subjective quality of life (QoL) was associated with higher odds of severe/extreme sleep difficulties (odds ratios [OR] = 4.590, 95% confidence interval [CI] = 2.641, 7.977 for South Africa, and OR = 4.461, 95% CI = 2.048 and 9.716 for Uganda). In Uganda, perceived depression was associated with higher odds of severe/extreme (OR = 2.452, 95% CI = 1.073, 5.602) sleep difficulties among men, and both mild/moderate (OR = 1.717; 95% CI = 1.011, 2.914) and severe/extreme sleep difficulties among women (OR = 2.504, 95% CI = 1.408, 4.453).More than half of the participants had sleep difficulty of certain degrees, emphasising an urgent need for intervention for sleep deprivation in the population. Interventions targeting to promote subjective health, quality of life, and living environment may prove beneficial for improving sleep health in this regard. FAU - Wang, Chao AU - Wang C AD - School of Safety Engineering. AD - School of Public Policy and Management, China University of Mining and Technology, Xuzhou, Jiangsu. FAU - Liu, Jiaxuan AU - Liu J AD - Queen Mary School, Nanchang University, Nanchang, Jiangxi. FAU - Li, Zhifei AU - Li Z AD - China National Center for Biotechnology Development, Beijing. FAU - Ji, Lu AU - Ji L AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Wang, Ruoxi AU - Wang R AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Song, Hongxun AU - Song H AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Mao, Yiqing AU - Mao Y AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. FAU - Bishwajit, Ghose AU - Bishwajit G AD - Faculty of Social Sciences, School of International Development and Global Studies, University of Ottawa, Ottawa, ON , Canada. FAU - Zhang, Baoming AU - Zhang B AD - General Hospital of Southern Theater Command, PLA, Guangzhou, P.R. China. FAU - Tang, Shangfeng AU - Tang S AD - School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology. AD - Research Center for Rural Health Service, Key Research Institute of Humanities & Social Sciences of Hubei Provincial Department of Education, Wuhan, Hubei. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Aged MH - Aged, 80 and over MH - Cross-Sectional Studies MH - Female MH - Humans MH - Independent Living MH - Male MH - Middle Aged MH - Prevalence MH - Self Report MH - Sleep Deprivation/*epidemiology/psychology MH - Sleep Initiation and Maintenance Disorders/*epidemiology/psychology MH - Sociological Factors MH - South Africa/epidemiology MH - Uganda/epidemiology PMC - PMC6882581 COIS- The authors have no conflicts of interest to disclose. EDAT- 2019/11/26 06:00 MHDA- 2019/12/18 06:00 PMCR- 2019/11/22 CRDT- 2019/11/26 06:00 PHST- 2019/11/26 06:00 [entrez] PHST- 2019/11/26 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/11/22 00:00 [pmc-release] AID - 00005792-201911220-00034 [pii] AID - MD-D-18-08546 [pii] AID - 10.1097/MD.0000000000017971 [doi] PST - ppublish SO - Medicine (Baltimore). 2019 Nov;98(47):e17971. doi: 10.1097/MD.0000000000017971. PMID- 27865528 OWN - NLM STAT- MEDLINE DCOM- 20180316 LR - 20181202 IS - 1879-1026 (Electronic) IS - 0048-9697 (Print) IS - 0048-9697 (Linking) VI - 579 DP - 2017 Feb 1 TI - Integrating new indicators of predictors that shape the public's perception of local extreme temperature in China. PG - 529-536 LID - S0048-9697(16)32503-7 [pii] LID - 10.1016/j.scitotenv.2016.11.064 [doi] AB - The public's risk perception of local extreme heat or cold plays a critical role in community health and prevention under climate change. However, there is limited evidence on such issues in China where extreme weather is occurring more frequently due to climate change. Here, a total of 2500 residents were selected using a three-step sampling method and investigated by a questionnaire in two representative cities. We investigated risk perception of extreme heat in Beijing and extreme cold in Harbin in 2013, aiming to examine their possible correlations with multiple epidemiological factors. We found that exposure, vulnerability, and adaptive ability were significant predictors in shaping public risk perceptions of local extreme temperature. In particular, a 1°C increase in daily temperature resulted in an increased odds of perceiving serious extreme heat in Beijing (OR=1.091; 95% CI: 1.032, 1.153), while a 1°C increase in daily temperature resulted in a decreased odds of perceiving serious extreme cold in Harbin (OR=0.965; 95% CI: 0.939, 0.992). Therefore for both extreme heat and cold, frequent local extreme temperature exposure may amplify a stronger communication. Health interventions for extreme temperature should consider exposure, vulnerability, and adaptive ability factors. This will help improve the public's perception of climatic changes and their willingness to balance adaption and mitigation appropriately. CI - Copyright © 2016 Elsevier B.V. All rights reserved. FAU - Ban, Jie AU - Ban J AD - Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 7 Panjiayuannanli, Chaoyang District, Beijing 100021, China. Electronic address: bjking99@126.com. FAU - Huang, Lei AU - Huang L AD - State Key Laboratory of Pollution Control & Resource Reuse, School of Environment, Nanjing University, No. 163 Xianlin Road, Xianlin District, Nanjing 210046, China. Electronic address: huanglei@nju.edu.cn. FAU - Chen, Chen AU - Chen C AD - Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 7 Panjiayuannanli, Chaoyang District, Beijing 100021, China. Electronic address: Chloechen.cdc@gmail.com. FAU - Guo, Yuming AU - Guo Y AD - Division of Epidemiology and Biostatistics, School of Public Health, University of Queensland, Level 2, Public Health Building, Herston Road, Herston, QLD 4006, Brisbane, Australia. Electronic address: y.guo1@uq.edu.au. FAU - He, Mike Z AU - He MZ AD - Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, 722 West 168th Street, New York, NY 10032, United States. Electronic address: zh2263@cumc.columbia.edu. FAU - Li, Tiantian AU - Li T AD - Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 7 Panjiayuannanli, Chaoyang District, Beijing 100021, China. Electronic address: tiantianli@gmail.com. LA - eng GR - T32 ES023770/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20161116 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - Beijing MH - China MH - Cities MH - *Climate Change MH - Environmental Monitoring/*methods MH - *Extreme Heat MH - Hot Temperature MH - Humans MH - *Perception MH - *Urban Population PMC - PMC5438083 MID - NIHMS856682 OTO - NOTNLM OT - Local extreme cold OT - Local extreme heat OT - Public risk perception COIS- Conflict of interest statement We declare that we have no conflict of interest. EDAT- 2016/11/21 06:00 MHDA- 2018/03/17 06:00 PMCR- 2017/05/19 CRDT- 2016/11/21 06:00 PHST- 2016/09/14 00:00 [received] PHST- 2016/11/09 00:00 [revised] PHST- 2016/11/10 00:00 [accepted] PHST- 2016/11/21 06:00 [pubmed] PHST- 2018/03/17 06:00 [medline] PHST- 2016/11/21 06:00 [entrez] PHST- 2017/05/19 00:00 [pmc-release] AID - S0048-9697(16)32503-7 [pii] AID - 10.1016/j.scitotenv.2016.11.064 [doi] PST - ppublish SO - Sci Total Environ. 2017 Feb 1;579:529-536. doi: 10.1016/j.scitotenv.2016.11.064. Epub 2016 Nov 16. PMID- 39693468 STAT- Publisher PB - Canadian Agency for Drugs and Technologies in Health CTI - CADTH Reimbursement Reviews and Recommendations DP - 2024 Nov BTI - Lebrikizumab (Ebglyss): Indication: For the treatment of moderate to severe atopic dermatitis in adults and adolescents 12 years of age and older with a body weight of at least 40 kg, whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. Lebrikizumab can be used with or without topical corticosteroids: Reimbursement Recommendation AB - WHAT IS CANADA’S DRUG AGENCY REIMBURSEMENT RECOMMENDATION FOR EBGLYSS? Canada’s Drug Agency (CDA-AMC) recommends that Ebglyss should not be reimbursed by public drug plans for the treatment of moderate to severe atopic dermatitis (AD) in adults and adolescents aged 12 years and older with a body weight of at least 40 kg, whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. WHY DID CDA-AMC MAKE THIS RECOMMENDATION? • Evidence from 3 clinical trials demonstrated that, in the short-term, Ebglyss treatment improved the severity of AD and reduced itch symptoms compared with placebo in adults and adolescents with moderate to severe AD. However, based on the evidence reviewed in the initial meeting and the reconsideration meeting, the Canadian Drug Expert Committee (CDEC) could not determine whether lebrikizumab would address the unmet needs of patients because of the uncertainty around the benefit of lebrikizumab versus appropriate comparators and in patients who received prior dupilumab or Janus kinase (JAK) inhibitor treatment. • No evidence was submitted that directly compared Ebglyss to currently available treatments for AD. The indirect evidence submitted had limitations that impacted the certainty of the evidence, and it was unclear if the estimates were valid. • The safety of Ebglyss relative to other treatments for AD is unknown because no comparative evidence was submitted. In addition, longer-term safety and efficacy was uncertain because of limitations of the study designs and analysis with the available evidence. ADDITIONAL INFORMATION: WHAT IS AD? AD is a condition that affects the skin and causes dry, red skin that is extremely itchy. Constant scratching causes the skin to split and bleed, which can lead to infections. Oozing and weeping sores occur in more severe forms. Severe AD can be physically incapacitating and cause anxiety or depression. AD affects around 20% of children, and up to 10% of adults in high-income countries. UNMET NEEDS IN AD: There is a potential need for additional treatment options that effectively reduce the severity and symptoms of AD, particularly in patients whose disease did not adequately respond to, or were deemed unsafe to receive, other biologics or JAK inhibitors. HOW MUCH DOES EBGLYSS COST? Treatment with Ebglyss is expected to cost approximately $35,657 per patient in the first year and approximately $24,397 per patient in subsequent years. LA - eng PT - Review PT - Book PL - Ottawa (ON) RF - 0 EDAT- 2024/11/01 00:00 CRDT- 2024/11/01 00:00 AID - NBK610231 [bookaccession] PMID- 34860947 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211206 IS - 8755-1225 (Print) IS - 1549-4810 (Electronic) IS - 1549-4810 (Linking) VI - 32 IP - 3 DP - 2016 Jun TI - Role of Bupropion Plus Naltrexone for the Management of Obesity. PG - 125-132 LID - 10.1177/8755122515624220 [doi] AB - Objective. The pharmacology, pharmacokinetics, efficacy, and safety of bupropion plus naltrexone for weight loss were reviewed. Data Sources. A MEDLINE search (1970 to November 2015) was conducted for English-language articles using specific MESH terms. Study Selection and Data Extraction. Published Phase 3 clinical trials with primary endpoints related to weight loss were included and critiqued in this review. Study Selection and Data Extraction. Five trials were retrieved and reviewed regarding the efficacy and safety of bupropion plus naltrexone among obese and overweight patients. Data Synthesis. Bupropion is a dopamine/norepinephrine reuptake inhibitor, and naltrexone is an opioid receptor antagonist. The combination of these agents has led to increased weight loss, compared to placebo, among overweight and obese patients with a body mass index (BMI) at or above 30 or BMI at or above 27 with a comorbid condition. The combination of bupropion and naltrexone can produce an average placebo-subtracted weight loss of 4.25% over 56 weeks. Gastrointestinal (ie, nausea, vomiting, constipation) and central nervous system adverse events (ie, headache, dizziness) were commonly reported, and there was a high dropout rate among participants. Conclusions. Bupropion plus naltrexone has demonstrated effective weight loss, in conjunction with lifestyle modifications, among overweight and obese patients with and without comorbidities. Bupropion plus naltrexone has not been studied among special patient populations, such as those with sleep apnea, osteoarthritis, or extreme BMIs. Additional clinical trials and postmarketing data will provide a better understanding of this medication for weight loss. CI - © The Author(s) 2016. FAU - Booth, Kemper AU - Booth K AD - Presbyterian College School of Pharmacy, Clinton, SC, USA. FAU - Clements, Jennifer N AU - Clements JN AD - Department of Pharmacy Practice, Presbyterian College, Clinton, SC, USA. LA - eng PT - Journal Article DEP - 20160111 PL - United States TA - J Pharm Technol JT - The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians JID - 8504643 PMC - PMC5998459 OTO - NOTNLM OT - adverse events OT - bupropion OT - efficacy OT - naltrexone OT - obesity OT - obesity management OT - overweight OT - pharmacotherapy OT - safety OT - weight loss COIS- Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2016/06/01 00:00 MHDA- 2016/06/01 00:01 PMCR- 2017/01/11 CRDT- 2021/12/03 17:29 PHST- 2021/12/03 17:29 [entrez] PHST- 2016/06/01 00:00 [pubmed] PHST- 2016/06/01 00:01 [medline] PHST- 2017/01/11 00:00 [pmc-release] AID - 10.1177_8755122515624220 [pii] AID - 10.1177/8755122515624220 [doi] PST - ppublish SO - J Pharm Technol. 2016 Jun;32(3):125-132. doi: 10.1177/8755122515624220. Epub 2016 Jan 11. PMID- 32557773 OWN - NLM STAT- MEDLINE DCOM- 20210729 LR - 20210729 IS - 1600-0609 (Electronic) IS - 0902-4441 (Linking) VI - 105 IP - 4 DP - 2020 Oct TI - Effectiveness and safety of apixaban and rivaroxaban for acute venous thromboembolism therapy in patients with extremes in bodyweight. PG - 484-494 LID - 10.1111/ejh.13471 [doi] AB - OBJECTIVES: To investigate the association of extremes in bodyweight (EBW) and outcomes in patients with acute venous thromboembolism (VTE). Recurrent VTE, major bleeding, and clinically relevant non-major bleeding were compared between patients with bodyweight <60 kg, 60-120 kg, and >120 kg. METHODS: Consecutive patients enrolled in the Mayo Clinic VTE Registry (03/28/2013-8/31/2019) with acute VTE were followed prospectively. Patient status was assessed in person, by mailing a written questionnaire, or by a scripted phone interview. RESULTS: Among 2577 patients with weight ranging from 27.0 kg to 263.2 kg, 2123 (82%) had a bodyweight between 60 and 120 kg, 223 (8.7%) had bodyweight < 60 kg, and 230 (8.9%) had bodyweight >120 kg. Patients with bodyweight <60 kg treated with DOACs had higher 3- and 6-month incidence of major bleeding compared to the bodyweight 60-120kg group (4.4% vs 1.1%, P = .03, and 4.4% vs 1.4%, P = .05, respectively). Patients with bodyweight >120 kg and cancer on rivaroxaban had higher VTE recurrence compared to bodyweight 60-120kg group (P = .01). CONCLUSIONS: Treatment of acute VTE is associated with a higher incidence of bleeding in patients with bodyweight <60 kg. A higher VTE recurrence rate occurred only in cancer patients with bodyweight >120 kg on rivaroxaban. CI - © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Wysokinski, Waldemar E AU - Wysokinski WE AUID- ORCID: 0000-0002-8119-6206 AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Froehling, David A AU - Froehling DA AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Houghton, Damon E AU - Houghton DE AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - McBane, Robert D AU - McBane RD AUID- ORCID: 0000-0001-8727-8029 AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Vlazny, Danielle T AU - Vlazny DT AUID- ORCID: 0000-0001-7074-6391 AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Bott-Kitslaar, Dalene M AU - Bott-Kitslaar DM AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Kuczmik, Wiktoria AU - Kuczmik W AD - Medical University of Silesia, Katowice, Poland. FAU - Sutkowska, Karolina AU - Sutkowska K AD - Wroclaw Medical University, Wroclaw, Poland. FAU - Bator, Kaja AU - Bator K AD - Wroclaw Medical University, Wroclaw, Poland. FAU - Hodge, David O AU - Hodge DO AD - Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA. FAU - Peterson, Lisa G AU - Peterson LG AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Casanegra, Ana I AU - Casanegra AI AUID- ORCID: 0000-0001-6114-4284 AD - Gonda Vascular Center, Thrombophilia Clinic, Division of Vascular Medicine, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. LA - eng GR - The discretionary fund from Gonda Vascular Center./Mayo Clinic/ PT - Journal Article DEP - 20200727 PL - England TA - Eur J Haematol JT - European journal of haematology JID - 8703985 RN - 0 (Anticoagulants) RN - 0 (Factor Xa Inhibitors) RN - 0 (Pyrazoles) RN - 0 (Pyridones) RN - 3Z9Y7UWC1J (apixaban) RN - 9NDF7JZ4M3 (Rivaroxaban) SB - IM MH - Acute Disease MH - Anticoagulants/administration & dosage/adverse effects/*therapeutic use MH - *Body Weight MH - Disease Management MH - Drug Therapy, Combination MH - Factor Xa Inhibitors/administration & dosage/adverse effects/*therapeutic use MH - Health Care Surveys MH - Hemorrhage/etiology MH - Humans MH - Pyrazoles/administration & dosage/adverse effects/*therapeutic use MH - Pyridones/administration & dosage/adverse effects/*therapeutic use MH - Registries MH - Rivaroxaban/administration & dosage/adverse effects/*therapeutic use MH - Venous Thromboembolism/complications/diagnosis/*drug therapy/*epidemiology OTO - NOTNLM OT - apixaban OT - bodyweight extremes OT - rivaroxaban OT - venous thromboembolism EDAT- 2020/06/20 06:00 MHDA- 2021/07/30 06:00 CRDT- 2020/06/20 06:00 PHST- 2020/04/27 00:00 [received] PHST- 2020/06/10 00:00 [revised] PHST- 2020/06/11 00:00 [accepted] PHST- 2020/06/20 06:00 [pubmed] PHST- 2021/07/30 06:00 [medline] PHST- 2020/06/20 06:00 [entrez] AID - 10.1111/ejh.13471 [doi] PST - ppublish SO - Eur J Haematol. 2020 Oct;105(4):484-494. doi: 10.1111/ejh.13471. Epub 2020 Jul 27. PMID- 23524397 OWN - NLM STAT- MEDLINE DCOM- 20140113 LR - 20130415 IS - 1095-8630 (Electronic) IS - 0301-4797 (Linking) VI - 121 DP - 2013 May 30 TI - An assessment of long-term overtopping risk and optimal termination time of dam under climate change. PG - 57-71 LID - S0301-4797(13)00113-8 [pii] LID - 10.1016/j.jenvman.2013.02.025 [doi] AB - Reservoir management faces a wide range of new challenges resulting from the impact of climate change. One set of challenges arises from the non-stationary nature of hydrological conditions. Another crucial issue is watershed sedimentation, which can significantly influence the sustainability and safety of reservoirs. To address these concerns, this study developed a framework for the management of reservoir risk. An analytical conceptual model coupling physical governing relationships and economic tools was proposed, which was then applied to the Shihmen Reservoir in Taiwan. We adopted a statistical representation of future hydrologic conditions with the assumption of time-variant moments and focused on evaluating the impact of an increase in the frequency of extreme hydrological events caused by climate change and used a stochastic approach to quantify the risk factors. Our results confirm that this approach can be used to identify reservoir-related risks and generate appropriate options for strategy and policy. We determined that the major source of risk is the hydrological conditions, especially the extreme events. More severe intra-annual climatic change is much more dominant in the risk compared to inter-year trends. The influence of reservoir characteristics on risk is associated mainly with the availability of flood control capacity, but limited due to the limitation of its volume and potential to regulate the flow. Engineering may provide an option for mitigating the risk, but integrated, watershed-level approaches, such as providing systematic detention or land use management, are better suited to reducing the storm peak from a long-term perspective. With a critical increase in the risk of overtopping, a high probability of dam failure and corresponding losses may precipitate the need to retire or remove the facility. However, because the benefits and costs are both huge, the decision may be biased by a conservative attitude. The outcome of small facilities failing may be considered more acceptable than similar events besetting larger systems. CI - Copyright © 2013 Elsevier Ltd. All rights reserved. FAU - Lee, Bau-Shian AU - Lee BS AD - Department of Civil Engineering, National Taiwan University, Taipei 10617, Taiwan. FAU - You, Gene Jiing-Yun AU - You GJ LA - eng PT - Journal Article DEP - 20130320 PL - England TA - J Environ Manage JT - Journal of environmental management JID - 0401664 SB - IM MH - *Climate Change MH - *Models, Theoretical MH - Risk Assessment MH - Taiwan MH - Time Factors MH - *Water Supply EDAT- 2013/03/26 06:00 MHDA- 2014/01/15 06:00 CRDT- 2013/03/26 06:00 PHST- 2012/09/13 00:00 [received] PHST- 2013/01/26 00:00 [revised] PHST- 2013/02/04 00:00 [accepted] PHST- 2013/03/26 06:00 [entrez] PHST- 2013/03/26 06:00 [pubmed] PHST- 2014/01/15 06:00 [medline] AID - S0301-4797(13)00113-8 [pii] AID - 10.1016/j.jenvman.2013.02.025 [doi] PST - ppublish SO - J Environ Manage. 2013 May 30;121:57-71. doi: 10.1016/j.jenvman.2013.02.025. Epub 2013 Mar 20. PMID- 22823283 OWN - NLM STAT- MEDLINE DCOM- 20130430 LR - 20220321 IS - 1537-2995 (Electronic) IS - 0041-1132 (Linking) VI - 53 IP - 3 DP - 2013 Mar TI - Laboratory evaluation of rapid test kits to detect hepatitis C antibody for use in predonation screening in emergency settings. PG - 505-17 LID - 10.1111/j.1537-2995.2012.03770.x [doi] AB - BACKGROUND: Emergency whole blood transfusion is a lifesaving procedure employed on modern battlefields. Rapid device tests (RDTs) are frequently used to mitigate transfusion-transmitted infection risks. STUDY DESIGN AND METHODS: A limited evaluation of the RDT formerly used on battlefields was performed using 50 donor plasma samples and commercially available panels. Five hepatitis C virus (HCV) RDTs with sufficient stated sensitivity and thermostability were assessed using 335 HCV-positive and 339 HCV-negative donor plasma samples, 54 seroconversion panel plasma samples, and 84 HCV-positive and 84 HCV-negative spiked whole blood under normal, hot, and cold storage conditions and normal and hot test conditions, plus an ease-of-use survey. RESULTS: BioRapid HCV test sensitivity on donor plasma was 84% (95% confidence interval [CI], 70.9%-92.8%). Using all positive plasma samples, OraQuick HCV sensitivity exceeded all comparators (99.4%, 95% CI, 98.0%-99.9%, p<0.05). Specificity was consistently high, led by OraQuick HCV at 99.7% (95% CI, 98.6%-100%), statistically superior only to Axiom HCV (p<0.05). Using seroconversion panels, only OraQuick HCV showed equivalent or earlier HCV detection compared to the gold standard. Using spiked whole blood, specificity was consistently high, and sensitivity ranged significantly from 34.5% (95% CI, 25.0%-45.1%) for CORE HCV to 98.8% (95% CI, 94.3%-99.9%) for OraQuick HCV. All comparator RDTs were significantly less sensitive than OraQuick HCV at one or more stress condition. CONCLUSION: This HCV RDT comparison identified significant sensitivity differences, particularly using whole blood under extreme storage and testing conditions. These data support OraQuick HCV superiority and illustrate the value of RDT evaluation under simulated field conditions. CI - © 2012 American Association of Blood Banks. FAU - O'Connell, Robert J AU - O'Connell RJ AD - Walter Reed Army Institute of Research, Silver Spring, Maryland, USA. roconnell@hivresearch.org FAU - Gates, Robert G AU - Gates RG FAU - Bautista, Christian T AU - Bautista CT FAU - Imbach, Michelle AU - Imbach M FAU - Eggleston, John C AU - Eggleston JC FAU - Beardsley, Stephen G AU - Beardsley SG FAU - Manak, Mark M AU - Manak MM FAU - Gonzales, Richard AU - Gonzales R FAU - Rentas, Francisco J AU - Rentas FJ FAU - Macdonald, Victor W AU - Macdonald VW FAU - Cardo, Lisa J AU - Cardo LJ FAU - Reiber, David T AU - Reiber DT FAU - Stramer, Susan L AU - Stramer SL FAU - Michael, Nelson L AU - Michael NL FAU - Peel, Sheila A AU - Peel SA LA - eng PT - Evaluation Study PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Validation Study DEP - 20120723 PL - United States TA - Transfusion JT - Transfusion JID - 0417360 RN - 0 (Hepatitis C Antibodies) RN - 0 (Reagent Kits, Diagnostic) SB - IM MH - Algorithms MH - *Blood Donors/statistics & numerical data MH - Blood Preservation/methods MH - Blood Safety MH - Clinical Laboratory Techniques/instrumentation/methods MH - Donor Selection/*methods MH - Efficiency MH - *Emergency Medical Services/methods/standards MH - Hepatitis C/blood/diagnosis MH - Hepatitis C Antibodies/analysis/*blood MH - Humans MH - *Reagent Kits, Diagnostic/standards MH - Sensitivity and Specificity MH - Time Factors EDAT- 2012/07/25 06:00 MHDA- 2013/05/01 06:00 CRDT- 2012/07/25 06:00 PHST- 2012/07/25 06:00 [entrez] PHST- 2012/07/25 06:00 [pubmed] PHST- 2013/05/01 06:00 [medline] AID - 10.1111/j.1537-2995.2012.03770.x [doi] PST - ppublish SO - Transfusion. 2013 Mar;53(3):505-17. doi: 10.1111/j.1537-2995.2012.03770.x. Epub 2012 Jul 23. PMID- 38372066 OWN - NLM STAT- MEDLINE DCOM- 20240429 LR - 20240429 IS - 1365-3040 (Electronic) IS - 0140-7791 (Linking) VI - 47 IP - 6 DP - 2024 Jun TI - Evidence of combined flower thermal and drought vulnerabilities portends reproductive failure under hotter-drought conditions. PG - 1971-1986 LID - 10.1111/pce.14857 [doi] AB - Despite the abundant evidence of impairments to plant performance and survival under hotter-drought conditions, little is known about the vulnerability of reproductive organs to climate extremes. Here, by conducting a comparative analysis between flowers and leaves, we investigated how variations in key morphophysiological traits related to carbon and water economics can explain the differential vulnerabilities to heat and drought among these functionally diverse organs. Due to their lower construction costs, despite having a higher water storage capacity, flowers were more prone to turgor loss (higher turgor loss point; Ψ(TLP)) than leaves, thus evidencing a trade-off between carbon investment and drought tolerance in reproductive organs. Importantly, the higher Ψ(TLP) of flowers also resulted in narrow turgor safety margins (TSM). Moreover, compared to leaves, the cuticle of flowers had an overall higher thermal vulnerability, which also resulted in low leakage safety margins (LSM). As a result, the combination of low TSMs and LSMs may have negative impacts on reproduction success since they strongly influenced the time to turgor loss under simulated hotter-drought conditions. Overall, our results improve the knowledge of unexplored aspects of flower structure and function and highlight likely threats to successful plant reproduction in a warmer and drier world. CI - © 2024 John Wiley & Sons Ltd. FAU - Aun, Marina Alves AU - Aun MA AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Farnese, Fernanda AU - Farnese F AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Loram-Lourenço, Lucas AU - Loram-Lourenço L AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - de Abreu, Igor Manoel Paulo Goulart AU - de Abreu IMPG AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Silva, Brenner Ryan Arantes AU - Silva BRA AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Freitas, Jober Condé Evangelista AU - Freitas JCE AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Filho, Valdeir Martins Alves AU - Filho VMA AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Silva, Fabiano Guimarães AU - Silva FG AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. FAU - Franco, Augusto Cesar AU - Franco AC AD - Department of Botany, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. FAU - Hammond, William M AU - Hammond WM AD - Department of Agronomy, University of Florida, Gainesville, Florida, USA. FAU - Cochard, Hervé AU - Cochard H AD - Université Clermont-Auvergne, INRAE, PIAF, Clermont-Ferrand, France. FAU - Menezes-Silva, Paulo Eduardo AU - Menezes-Silva PE AUID- ORCID: 0000-0002-8122-3489 AD - Federal Institute of Education, Science and Technology Goiano, Rio Verde Campus, Rio Verde, Brazil. LA - eng GR - 314237/2021-6/Conselho Nacional de Desenvolvimento Científico e Tecnológico/ GR - 314719/2020-2/Conselho Nacional de Desenvolvimento Científico e Tecnológico/ GR - 311362/2019-2/Conselho Nacional de Desenvolvimento Científico e Tecnológico/ GR - 202310267000543/Fundação de Amparo à Pesquisa do Estado de Goiás/ GR - 88887.837697/2023-00/Fundação de Amparo à Pesquisa do Estado de Goiás/ GR - University of Florida/ GR - Instituto Federal Goiano, Campus Rio Verde/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240219 PL - United States TA - Plant Cell Environ JT - Plant, cell & environment JID - 9309004 RN - 059QF0KO0R (Water) SB - IM MH - *Flowers/physiology MH - *Droughts MH - *Hot Temperature MH - *Plant Leaves/physiology MH - *Reproduction MH - Water/metabolism/physiology OTO - NOTNLM OT - climate change OT - drought tolerance OT - flower hydraulics OT - plant reproduction OT - thermal vulnerability EDAT- 2024/02/19 06:44 MHDA- 2024/04/29 06:44 CRDT- 2024/02/19 04:39 PHST- 2024/01/30 00:00 [revised] PHST- 2023/09/06 00:00 [received] PHST- 2024/02/01 00:00 [accepted] PHST- 2024/04/29 06:44 [medline] PHST- 2024/02/19 06:44 [pubmed] PHST- 2024/02/19 04:39 [entrez] AID - 10.1111/pce.14857 [doi] PST - ppublish SO - Plant Cell Environ. 2024 Jun;47(6):1971-1986. doi: 10.1111/pce.14857. Epub 2024 Feb 19. PMID- 36892263 OWN - NLM STAT- Publisher LR - 20240216 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) DP - 2023 Mar 9 TI - Dual-Phasic, Well-Aligned, and Strong Flexible Hydrophobic Ceramic Membranes for Efficient Thermal Insulation in Extreme Conditions. LID - 10.1021/acsami.3c00263 [doi] AB - The inherent brittleness and hydrophilicity of ceramics pose a great challenge to designing a reliable structure that can resist mechanical loads and moisture in extreme conditions with high temperature and high humidity. Here, we report a two-phase hydrophobic silica-zirconia composite ceramic nanofiber membrane (H-ZSNFM) with exceptional mechanical robustness and high-temperature hydrophobic resistance. For the dual-phasic nanofibers, the amorphous silica blocked the connection of zirconia nanocrystals, and the lattice distortion was observed due to Si in the ZrO(2) lattice. H-ZSNFM has strong strength (5-8.4 MPa), high hydrophobic temperature resistance (450 °C), high porosity (89%), low density (40 mg/cm(3)), low thermal conductivity (30 mW/m·K), and excellent thermal radiation reflectivity (90%). By simulating the actual high-temperature and high-humidity environment, 10-mm-thick H-ZSNFMs can reduce the heat source from 1365 to 380 °C and maintain complete hydrophobicity even in a water vapor environment of 350 °C. This means that it has superior insulation and waterproof performance even in a high-temperature water environment. For firefighting clothing, H-ZSNFM displayed waterproof and insulation layers, which have excellent thermal protection performance and achieve incompatibility between water and fire, providing valuable time for fire rescue and a safety line of defense for emergency personnel. This design strategy with mechanical robust and hydrophobic temperature resistance applies to the development of many other types of high-performance thermal insulation materials and presents a competitive material system for thermal protection in extreme conditions. FAU - Peng, Ying AU - Peng Y AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Xie, Yongshuai AU - Xie Y AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. AD - National Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, Harbin 150001, P. R. China. FAU - Deng, Zhezhe AU - Deng Z AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Ma, Dehua AU - Ma D AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Liu, Benxue AU - Liu B AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Wang, Xinqiang AU - Wang X AUID- ORCID: 0000-0002-2589-6232 AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Zhang, Guanghui AU - Zhang G AUID- ORCID: 0000-0002-8511-1599 AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. FAU - Zhu, Luyi AU - Zhu L AUID- ORCID: 0000-0003-0774-8866 AD - State Key Laboratory of Crystal Materials, Institute of Crystal Materials, Shandong University, Jinan 250100, P. R. China. LA - eng PT - Journal Article DEP - 20230309 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - H-ZSNFMs OT - high temperature OT - hydrophobicity OT - mechanical property OT - thermal insulation EDAT- 2023/03/10 06:00 MHDA- 2023/03/10 06:00 CRDT- 2023/03/09 08:43 PHST- 2023/03/09 08:43 [entrez] PHST- 2023/03/10 06:00 [pubmed] PHST- 2023/03/10 06:00 [medline] AID - 10.1021/acsami.3c00263 [doi] PST - aheadofprint SO - ACS Appl Mater Interfaces. 2023 Mar 9. doi: 10.1021/acsami.3c00263. PMID- 35038335 OWN - NLM STAT- MEDLINE DCOM- 20220713 LR - 20220825 IS - 1758-4469 (Electronic) IS - 0829-318X (Linking) VI - 42 IP - 7 DP - 2022 Jul 5 TI - Post-drought conditions and hydraulic dysfunction determine tree resilience and mortality across Mediterranean Aleppo pine (Pinus halepensis) populations after an extreme drought event. PG - 1364-1376 LID - 10.1093/treephys/tpac001 [doi] AB - Drought-related tree mortality is a global phenomenon that currently affects a wide range of forests. Key functional variables on plant hydraulics, carbon economy, growth and allocation have been identified and play a role in tree drought responses. However, tree mortality thresholds based on such variables are difficult to identify, especially under field conditions. We studied several Aleppo pine populations differently affected by an extreme drought event in 2014, with mortality rates ranging from no mortality to 90% in the most severely affected population. We hypothesized that mortality is linked with high levels of xylem embolism, i.e., hydraulic dysfunction, which would also lead to lower tree resistance to drought in subsequent years. Despite not finding any differences among populations in the vulnerability curves to xylem embolism, there were large differences in the hydraulic safety margin (HSM) and the hydraulic dysfunction level. High mortality rates were associated with a negative HSM when xylem embolism reached values over 60%. We also found forest weakening and post-drought mortality related to a low hydraulic water transport capacity, reduced plant growth, low carbohydrate contents and high pest infestation rates. Our results highlight the importance of drought severity and the hydraulic dysfunction level on pine mortality, as well as post-drought conditions during recovery processes. CI - © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Morcillo, L AU - Morcillo L AD - Mediterranean Center for Environmental Studies (CEAM Foundation), Joint Research Unit University of Alicante-CEAM, University of Alicante, Alicante 03690, Spain. FAU - Muñoz-Rengifo, J C AU - Muñoz-Rengifo JC AD - Department of Ecology, University of Alicante, Alicante 03690, Spain. AD - Department of Earth Science, Universidad Estatal Amazónica, Pastaza 160150, Ecuador. FAU - Torres-Ruiz, J M AU - Torres-Ruiz JM AD - Université Clermont-Auvergne, INRAE, PIAF, Clermont-Ferrand 63000, France. FAU - Delzon, S AU - Delzon S AD - Université Bordeaux, INRAE, BIOGECO, Pessac 33615, France. FAU - Moutahir, H AU - Moutahir H AD - Mediterranean Center for Environmental Studies (CEAM Foundation), Joint Research Unit University of Alicante-CEAM, University of Alicante, Alicante 03690, Spain. FAU - Vilagrosa, A AU - Vilagrosa A AUID- ORCID: 0000-0002-1432-1214 AD - Mediterranean Center for Environmental Studies (CEAM Foundation), Joint Research Unit University of Alicante-CEAM, University of Alicante, Alicante 03690, Spain. AD - Department of Ecology, University of Alicante, Alicante 03690, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Canada TA - Tree Physiol JT - Tree physiology JID - 100955338 RN - 059QF0KO0R (Water) SB - IM MH - Droughts MH - Forests MH - *Pinus/physiology MH - *Trees/physiology MH - Water/physiology MH - Xylem/physiology OTO - NOTNLM OT - Pinus halepensis OT - biotic attacks OT - drought legacy OT - forest decline OT - global change OT - xylem cavitation EDAT- 2022/01/18 06:00 MHDA- 2022/07/14 06:00 CRDT- 2022/01/17 17:10 PHST- 2021/01/12 00:00 [received] PHST- 2022/01/11 00:00 [accepted] PHST- 2022/01/18 06:00 [pubmed] PHST- 2022/07/14 06:00 [medline] PHST- 2022/01/17 17:10 [entrez] AID - 6508699 [pii] AID - 10.1093/treephys/tpac001 [doi] PST - ppublish SO - Tree Physiol. 2022 Jul 5;42(7):1364-1376. doi: 10.1093/treephys/tpac001. PMID- 38876127 OWN - NLM STAT- MEDLINE DCOM- 20240725 LR - 20240725 IS - 2665-9913 (Electronic) IS - 2665-9913 (Linking) VI - 6 IP - 8 DP - 2024 Aug TI - The outcomes of children born to mothers with autoimmune rheumatic diseases. PG - e573-e586 LID - S2665-9913(24)00096-1 [pii] LID - 10.1016/S2665-9913(24)00096-1 [doi] AB - Maternal autoimmune rheumatic diseases can influence the outcomes of children through several life stages. During pregnancy, maternal inflammation and autoantibodies can hinder fetal development and lead to growth restriction, preterm birth, and low birth weight; prematurity, especially at extreme gestational ages, can in turn impair future child health. Treatment with compatible immunomodulatory drugs and preventive medications aims to keep maternal disease under control and minimise the risk of adverse pregnancy outcomes. However, concerns have been raised about the effects of immunomodulatory drugs on neonatal conditions (ie, the risk of serious infections, inadequate responses to vaccinations, and organ toxicity) and long-term outcomes (metabolic and cardiovascular problems and neurodevelopmental disorders). Among the unmet needs of parents with autoimmune rheumatic diseases, there is the estimation of risk for the children to develop autoimmune disorders and the need for reassurance about parenting capacity while living with a chronic condition. This Series paper provides a comprehensive overview of the literature and guidance on discussing these topics with patients. CI - Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies. FAU - Andreoli, Laura AU - Andreoli L AD - Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Danish Centre for Expertise in Rheumatology, Danish Hospital for Rheumatic Diseases, Sonderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. FAU - Andersen, Jeanette AU - Andersen J AD - Lupus Europe, Knebel, Denmark. FAU - Avcin, Tadej AU - Avcin T AD - Department of Allergology, Rheumatology and Clinical Immunology, ERN RITA, ERN ReCONNET, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia; Department of Pediatrics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Chambers, Christina D AU - Chambers CD AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. FAU - Fazzi, Elisa M AU - Fazzi EM AD - Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; Child Neurology and Psychiatry Unit, ASST Spedali Civili, Brescia, Italy. FAU - Marlow, Neil AU - Marlow N AD - UCL Elizabeth Garret Anderson Institute for Women's Health, University College London, London, UK. FAU - Wulffraat, Nico M AU - Wulffraat NM AD - Department of Pediatric Rheumatology and Immunology, ERN RITA, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. FAU - Tincani, Angela AU - Tincani A AD - Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address: angela.tincani@unibs.it. LA - eng PT - Journal Article PT - Review DEP - 20240611 PL - England TA - Lancet Rheumatol JT - The Lancet. Rheumatology JID - 101765308 SB - IM MH - Humans MH - *Rheumatic Diseases/immunology/drug therapy MH - Pregnancy MH - Female MH - *Autoimmune Diseases/immunology MH - Infant, Newborn MH - *Pregnancy Complications/immunology/drug therapy MH - Pregnancy Outcome/epidemiology MH - Prenatal Exposure Delayed Effects/immunology MH - Child MH - Premature Birth COIS- Declaration of interests LA reports consulting fees from UCB and speaking and writing fees from AlfaSigma, GSK, Janssen, Novartis, Pfizer, UCB, and the Werfen Group. JA is the Chair of Lupus Europe, which is funded mostly by grants or donations from pharmaceutical companies (Amgen/Horizon, AstraZeneca, Biogen, BMS, Boehringer Ingelheim, Galapagos, GSK, Idorsia, Janssen, Merck, Novartis, Otsuka, Roche, and UCB), none of which exceeds 25% of the total funds collected and none of whom have a say on the content of studies or work produced by Lupus Europe. TA reports consulting fees from Novartis and speaking and writing fees from AbbVie, Novartis, Pfizer, and Swedish Orphan Biovitrum. CDC reports research grants from Amgen, AstraZeneca, Genzyme Sanofi-Aventis, Gilead, GSK, Hoffman La-Roche-Genentech, Janssen, Leo Pharma, Novartis, Pfizer, Regeneron, Sanofi, Sun Pharma Global FZE, Takeda, the Gerber Foundation, and UCB. NM reports consulting fees as an expert advisor from RSM Consulting; speaking fees from Chiesi; and serves as a data safety monitoring board member in two National Institute for Health and Care Research Health Technology Assessment (NIHR HTA) trials and as the Trial Steering Committee Chair in a NIHR HTA trial. AT reports consulting fees from GSK and UCB and participated in advisory boards for Galapagos and UCB. All other authors declare no competing interest. EDAT- 2024/06/15 10:43 MHDA- 2024/07/26 12:40 CRDT- 2024/06/14 18:53 PHST- 2024/01/27 00:00 [received] PHST- 2024/04/03 00:00 [revised] PHST- 2024/04/10 00:00 [accepted] PHST- 2024/07/26 12:40 [medline] PHST- 2024/06/15 10:43 [pubmed] PHST- 2024/06/14 18:53 [entrez] AID - S2665-9913(24)00096-1 [pii] AID - 10.1016/S2665-9913(24)00096-1 [doi] PST - ppublish SO - Lancet Rheumatol. 2024 Aug;6(8):e573-e586. doi: 10.1016/S2665-9913(24)00096-1. Epub 2024 Jun 11. PMID- 2489292 OWN - NLM STAT- MEDLINE DCOM- 19910606 LR - 20110729 IS - 0029-8484 (Print) IS - 0029-8484 (Linking) VI - 77 IP - SPEC DP - 1989 Oct TI - [Osseointegrated implants in clinical dentistry from the point of view of prosthodontics]. PG - 1223-34 AB - With the life expectancy of our country reaching 80s we are encountering a society with greater proportion of the population in old ages. This social problem creates a relatively important assignment in the area of prosthodontics, especially in full denture prosthodontics. Though the most important factor that affects the success or failure of full denture prosthodontics is the condition of the residual ridge, recent studies have shown that the residual ridges continue to resorb throughout one's life span. Also our survey on the present Japanese denture patients tells us that an average person becomes edentulous at an age of 57.6, has made a full denture twice or more, has worn the denture for 8 to 10 years, and by age 65 to 67 over half of the patients have their mandibular residual ridges being even or the ridge has resorbed extremely so that the ridge is actually lower than the floor of the mouth. With the situation as it is, when we look into the future of the full denture prosthodontics it is inevitable that there will be a rapid increase in patients with extremely resorbed ridges which the present theory of full denture prosthodontics could not handle. In this sense, prosthodontic treatment of edentulous patients with implants is a relatively interesting field. In this article we will comment of the basic application technique and the prosthodontic technique which we have improved of the Brånemark's Osseointegrated implants which possess the long term basic objective clinical data and whose long term safety has been established in edentulous patients. First we will explain the basic application technique using a real case. The patient was a 56 years old female. She came to the clinic with the chief complaint of severe masticatory dysfunction due to unstable full dentures. She strongly desired fixed prosthodontics. She had worn dentures for the past 17 years. The dentures that she had on when she came in for the first visit were her 4th set of dentures. For the past 8 years she had her dentures adjusted and rebased repeatedly. Her maxillary residual ridge had an average height but her mandibular residual ridge was extremely resorbed. EMG examination exhibited conspicuous distortion in chewing rhythm. From the mandibular movement, radiographs of the TMJ regions and the clinical observations it was determined that the vertical dimension had been lost and that her mandible was displaced toward her left and anteriorly. Palpation indicated the condition of muscular tension similar to that of TMJ dysfunction patients.(ABSTRACT TRUNCATED AT 400 WORDS) FAU - Kobayashi, Y AU - Kobayashi Y LA - jpn PT - Case Reports PT - English Abstract PT - Journal Article PL - Japan TA - Shigaku JT - Shigaku = Odontology; journal of Nihon Dental College JID - 1275704 MH - Dental Implantation, Endosseous/*methods MH - *Dental Impression Technique MH - *Denture Design MH - Denture, Complete MH - Denture, Overlay MH - Female MH - Humans MH - Middle Aged MH - *Osseointegration EDAT- 1989/10/01 00:00 MHDA- 1989/10/01 00:01 CRDT- 1989/10/01 00:00 PHST- 1989/10/01 00:00 [pubmed] PHST- 1989/10/01 00:01 [medline] PHST- 1989/10/01 00:00 [entrez] PST - ppublish SO - Shigaku. 1989 Oct;77(SPEC):1223-34. PMID- 24474044 OWN - NLM STAT- MEDLINE DCOM- 20150420 LR - 20160519 IS - 1868-4297 (Electronic) IS - 1868-4297 (Linking) VI - 29 IP - 3 DP - 2014 Jul TI - Safety margin of minimized contrast volume during percutaneous coronary intervention in patients with chronic kidney disease. PG - 209-15 LID - 10.1007/s12928-014-0245-9 [doi] AB - Maximum allowable contrast dose (MACD) calculated as body weight × 5/serum creatinine has been a standard contrast dye volume (CV) used to decrease contrast-induced acute kidney injury. Recent advances in intravascular ultrasound-guided percutaneous coronary intervention (PCI) can dramatically minimize CV. The safe threshold when using an extremely low-dose CV is unknown. This study was designed as a multicenter, retrospective study of chronic kidney disease (CKD) patients with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m(2) undergoing elective PCI. We divided the patients into three groups according to following criteria: (1) low dose, CV/eGFR ratio <1.0; (2) medium dose, CV/eGFR ratio ≥1 and 20 billion doses of probiotics are used by healthy people and by those diagnosed with a range of medical conditions. Compared to many pharmaceutical agents, probiotics are well tolerated and extremely safe, and serious adverse effects rarely occur. Nevertheless, as many new researchers enter the field and companies launch "probiotic" products, it is essential that standards are set for naming a product "probiotic" to show that it meets an acceptable level of safety and efficacy, and to understand the strengths and limitations of its activity. In this Opinion article, recommendations are made based upon the current understanding of scientific, clinical and regulatory issues, with a special focus on safety. FAU - Reid, Gregor AU - Reid G AD - Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute and Departments of Microbiology & Immunology and Surgery, The University of Western Ontario, London, Ontario N6A 4V2, Canada. gregor@uwo.ca LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060630 PL - England TA - Trends Microbiol JT - Trends in microbiology JID - 9310916 SB - IM MH - Animals MH - Consumer Product Safety/legislation & jurisprudence/standards MH - Guidelines as Topic MH - Humans MH - Legislation, Food/*standards/trends MH - Probiotics/adverse effects/*standards/therapeutic use EDAT- 2006/07/01 09:00 MHDA- 2006/09/27 09:00 CRDT- 2006/07/01 09:00 PHST- 2006/02/02 00:00 [received] PHST- 2006/05/23 00:00 [revised] PHST- 2006/06/14 00:00 [accepted] PHST- 2006/07/01 09:00 [pubmed] PHST- 2006/09/27 09:00 [medline] PHST- 2006/07/01 09:00 [entrez] AID - S0966-842X(06)00151-X [pii] AID - 10.1016/j.tim.2006.06.006 [doi] PST - ppublish SO - Trends Microbiol. 2006 Aug;14(8):348-52. doi: 10.1016/j.tim.2006.06.006. Epub 2006 Jun 30. PMID- 22317184 OWN - NLM STAT- MEDLINE DCOM- 20141210 LR - 20191210 IS - 1875-9270 (Electronic) IS - 1051-9815 (Linking) VI - 41 Suppl 1 DP - 2012 TI - Whistleblowers: an essential resource for the sustainable prevention of risks in sociotechnical systems. PG - 3051-61 LID - 10.3233/WOR-2012-0563-3051 [doi] AB - Our world of industry and technology has, over the years, has seen undeniable successes in terms of safety and reliability. But major catastrophes and dramatic accidents continue, even today, to cause major human and material losses and to threaten the environment with pollution on a massive scale. Could these disasters and these accidents have been foreseen and avoided? Would it have been possible to anticipate their occurrence by detecting signals of potential hazards? It is unsettling to notice, through retrospective analysis of such events, that warnings had been issued long before the catastrophe or accident took place. This raises several questions, which we will attempt to address in this paper. Why are whistleblowers often not listened to, threatened, or simply ignored? Why are their warnings viewed as "bad omens" instead of essential resources to ensure safety? Do whistleblowers stand idly by, or do they implement individual and collective strategies to make themselves heard? Which managerial and organizational conditions are conducive to developing empowerment in whistleblowers? Based on four case studies, we attempt to address these questions, and offer a first level of analysis and explanation by proposing and defining two new concepts: operative resilience and strategic resilience. FAU - Benchekroun, Tahar Hakim AU - Benchekroun TH AD - Conservatoire National des Arts et Métiers, Centre de Recherche sur le Travail et Développement (CRTD), 41 rue Gay-Lussac, 75005 Paris, France. tahar-hakim.benchekroun@cnam.fr FAU - Pierlot, Sandrine AU - Pierlot S LA - eng PT - Journal Article PL - United States TA - Work JT - Work (Reading, Mass.) JID - 9204382 SB - IM MH - *Accident Prevention MH - Disasters/*prevention & control MH - Extreme Heat MH - Humans MH - Nuclear Power Plants MH - Organizational Culture MH - Power, Psychological MH - Resilience, Psychological MH - Seveso Accidental Release MH - Spacecraft MH - *Whistleblowing/psychology EDAT- 2012/02/10 06:00 MHDA- 2014/12/15 06:00 CRDT- 2012/02/10 06:00 PHST- 2012/02/10 06:00 [entrez] PHST- 2012/02/10 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - 8152U735668285W0 [pii] AID - 10.3233/WOR-2012-0563-3051 [doi] PST - ppublish SO - Work. 2012;41 Suppl 1:3051-61. doi: 10.3233/WOR-2012-0563-3051. PMID- 22789835 OWN - NLM STAT- MEDLINE DCOM- 20130805 LR - 20220318 IS - 1532-866X (Electronic) IS - 0049-0172 (Linking) VI - 42 IP - 4 DP - 2013 Feb TI - Therapeutic inhibition of tyrosine kinases in systemic sclerosis: a review of published experience on the first 108 patients treated with imatinib. PG - 377-90 LID - S0049-0172(12)00139-4 [pii] LID - 10.1016/j.semarthrit.2012.06.001 [doi] AB - OBJECTIVE: Experimental and clinical evidence suggest a therapeutic role for the tyrosine kinase inhibitor imatinib in fibrosing conditions. We evaluated published data on the safety and efficacy of imatinib for patients with systemic sclerosis (SSc), a severe autoimmune disease with significant morbidity and mortality. METHODS: A careful search for all original articles and abstracts on the use of imatinib in SSc published in English from 2008 through February 2012 was performed. Two additional patients from our center are also described. RESULTS: Five small observational clinical trials on the use of imatinib in severe SSc have been conducted and case reports and small series of refractory to current approaches patients have been reported, adding to a total of 108 patients having received this drug to date. In most of these patients imatinib was given for skin or pulmonary fibrosis. Encouraging results were reported in 3 of 4 studies, whereas the fifth study was prematurely terminated for safety reasons. Overall, clinical results are highly variable, ranging from ineffective or toxic responses to extremely encouraging clinical improvements in some severely ill patients. These discrepancies could partly reflect imatinib-related safety issues, in particular, SSc patients or idiosyncratic resistance to imatinib, as happens in chronic myelogenous leukemia and gastrointestinal stromal tumors, the drug's approved indications. CONCLUSIONS: The limited available experience suggests that imatinib could be considered as an individualized treatment approach in severe SSc and underscores the need to identify markers for selecting particular patients, who will safely respond to therapeutic inhibition of tyrosine kinases. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - Bournia, Vasiliki-Kalliopi AU - Bournia VK AD - First Department of Propedeutic and Internal Medicine, Laikon Hospital, Athens, Greece. FAU - Evangelou, Konstantinos AU - Evangelou K FAU - Sfikakis, Petros P AU - Sfikakis PP LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20120711 PL - United States TA - Semin Arthritis Rheum JT - Seminars in arthritis and rheumatism JID - 1306053 RN - 0 (Benzamides) RN - 0 (Piperazines) RN - 0 (Protein Kinase Inhibitors) RN - 0 (Pyrimidines) RN - 8A1O1M485B (Imatinib Mesylate) SB - IM MH - Benzamides/adverse effects/*therapeutic use MH - Humans MH - Imatinib Mesylate MH - Piperazines/adverse effects/*therapeutic use MH - Protein Kinase Inhibitors/adverse effects/*therapeutic use MH - Pyrimidines/adverse effects/*therapeutic use MH - Scleroderma, Systemic/*drug therapy MH - Treatment Outcome EDAT- 2012/07/14 06:00 MHDA- 2013/08/06 06:00 CRDT- 2012/07/14 06:00 PHST- 2012/02/25 00:00 [received] PHST- 2012/05/27 00:00 [revised] PHST- 2012/06/03 00:00 [accepted] PHST- 2012/07/14 06:00 [entrez] PHST- 2012/07/14 06:00 [pubmed] PHST- 2013/08/06 06:00 [medline] AID - S0049-0172(12)00139-4 [pii] AID - 10.1016/j.semarthrit.2012.06.001 [doi] PST - ppublish SO - Semin Arthritis Rheum. 2013 Feb;42(4):377-90. doi: 10.1016/j.semarthrit.2012.06.001. Epub 2012 Jul 11. PMID- 28421064 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 8 DP - 2017 TI - Current Perspectives on Viable but Non-culturable State in Foodborne Pathogens. PG - 580 LID - 10.3389/fmicb.2017.00580 [doi] LID - 580 AB - The viable but non-culturable (VBNC) state, a unique state in which a number of bacteria respond to adverse circumstances, was first discovered in 1982. Unfortunately, it has been reported that many foodborne pathogens can be induced to enter the VBNC state by the limiting environmental conditions during food processing and preservation, such as extreme temperatures, drying, irradiation, pulsed electric field, and high pressure stress, as well as the addition of preservatives and disinfectants. After entering the VBNC state, foodborne pathogens will introduce a serious crisis to food safety and public health because they cannot be detected using conventional plate counting techniques. This review provides an overview of the various features of the VBNC state, including the biological characteristics, induction and resuscitation factors, formation and resuscitation mechanisms, detection methods, and relationship to food safety. FAU - Zhao, Xihong AU - Zhao X AD - Key Laboratory for Green Chemical Process of Ministry of Education, Key Laboratory for Hubei Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of TechnologyWuhan, China. FAU - Zhong, Junliang AU - Zhong J AD - Key Laboratory for Green Chemical Process of Ministry of Education, Key Laboratory for Hubei Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of TechnologyWuhan, China. FAU - Wei, Caijiao AU - Wei C AD - Key Laboratory for Green Chemical Process of Ministry of Education, Key Laboratory for Hubei Novel Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of TechnologyWuhan, China. FAU - Lin, Chii-Wann AU - Lin CW AD - Institute of Biomedical Engineering, National Taiwan UniversityTaipei, Taiwan. FAU - Ding, Tian AU - Ding T AD - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang UniversityHangzhou, China. LA - eng PT - Journal Article PT - Review DEP - 20170404 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC5378802 OTO - NOTNLM OT - VBNC OT - detection method OT - foodborne pathogens OT - induction OT - resuscitation EDAT- 2017/04/20 06:00 MHDA- 2017/04/20 06:01 PMCR- 2017/04/04 CRDT- 2017/04/20 06:00 PHST- 2016/10/19 00:00 [received] PHST- 2017/03/21 00:00 [accepted] PHST- 2017/04/20 06:00 [entrez] PHST- 2017/04/20 06:00 [pubmed] PHST- 2017/04/20 06:01 [medline] PHST- 2017/04/04 00:00 [pmc-release] AID - 10.3389/fmicb.2017.00580 [doi] PST - epublish SO - Front Microbiol. 2017 Apr 4;8:580. doi: 10.3389/fmicb.2017.00580. eCollection 2017. PMID- 33489284 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210126 IS - 2054-5703 (Print) IS - 2054-5703 (Electronic) IS - 2054-5703 (Linking) VI - 7 IP - 12 DP - 2020 Dec TI - A system for efficient egress scheduling during mass events and small-scale experimental demonstration. PG - 201465 LID - 10.1098/rsos.201465 [doi] LID - 201465 AB - Improvements in the design of pedestrian facilities have reduced the frequency of crowd accidents, and safety is now generally ensured in well-planned crowd events. However, congestion and inefficient use of infrastructures still remain an issue. To guarantee comfort and reduce close contacts between people, there are circumstances when crowd density may have to be reduced well below safety limits. Although research has given a lot of attention to extreme scenarios, methods to improve non-critical conditions have been little explored. In addition, crowd sensing technology is still mostly used for data collection and direct use on crowd management is rare. In this work, we present a system aimed at computing optimal egress time for groups of people leaving a complex facility. We show that, if egress starting time is accurately computed for each group based on actual crowd conditions, density can be greatly reduced without having a large effect on the total egress time of the whole crowd. To show the efficacy of such a system, a small-scale experiment is conducted where all components are tested in a simple scenario. As a result, an increase in total egress time by only 5% allowed to reduce maximum density by 35%. CI - © 2020 The Authors. FAU - Murakami, Hisashi AU - Murakami H AUID- ORCID: 0000-0002-1433-0524 AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. FAU - Feliciani, Claudio AU - Feliciani C AUID- ORCID: 0000-0003-0718-8707 AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. FAU - Shimura, Kenichiro AU - Shimura K AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. FAU - Nishinari, Katsuhiro AU - Nishinari K AD - Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. AD - Department of Aeronautics and Astronautics, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. LA - eng SI - figshare/10.6084/m9.figshare.c.5221490 PT - Journal Article DEP - 20201209 PL - England TA - R Soc Open Sci JT - Royal Society open science JID - 101647528 PMC - PMC7813256 OTO - NOTNLM OT - crowd dynamics OT - dynamic scheduling OT - egress OT - pedestrian sensing OT - pedestrian traffic OT - real-time simulation COIS- We declare we have no competing interests. EDAT- 2021/01/26 06:00 MHDA- 2021/01/26 06:01 PMCR- 2020/12/09 CRDT- 2021/01/25 05:41 PHST- 2020/08/17 00:00 [received] PHST- 2020/11/10 00:00 [accepted] PHST- 2021/01/25 05:41 [entrez] PHST- 2021/01/26 06:00 [pubmed] PHST- 2021/01/26 06:01 [medline] PHST- 2020/12/09 00:00 [pmc-release] AID - rsos201465 [pii] AID - 10.1098/rsos.201465 [doi] PST - epublish SO - R Soc Open Sci. 2020 Dec 9;7(12):201465. doi: 10.1098/rsos.201465. eCollection 2020 Dec. PMID- 16390950 OWN - NLM STAT- MEDLINE DCOM- 20060321 LR - 20181113 IS - 0095-1137 (Print) IS - 1098-660X (Electronic) IS - 0095-1137 (Linking) VI - 44 IP - 1 DP - 2006 Jan TI - Armored RNA as virus surrogate in a real-time reverse transcriptase PCR assay proficiency panel. PG - 67-70 AB - In recent years testing responsibilities for high-consequence pathogens have been expanded from national reference laboratories into networks of local and regional laboratories in order to support enhanced disease surveillance and to test for surge capacity. This movement of testing of select agents and high-consequence pathogens beyond reference laboratories introduces a critical need for standardized, noninfectious surrogates of disease agents for use as training and proficiency test samples. In this study, reverse transcription-PCR assay RNA targets were developed and packaged as armored RNA for use as a noninfectious, quantifiable synthetic substitute for four high-consequence animal pathogens: classical swine fever virus; foot-and-mouth disease virus; vesicular stomatitis virus, New Jersey serogroup; and vesicular stomatitis virus, Indiana serogroup. Armored RNA spiked into oral swab fluid specimens mimicked virus-positive clinical material through all stages of the reverse transcription-PCR testing process, including RNA recovery by four different commercial extraction procedures, reverse transcription, PCR amplification, and real-time detection at target concentrations consistent with the dynamic ranges of the existing real-time PCR assays. The armored RNA concentrations spiked into the oral swab fluid specimens were stable under storage conditions selected to approximate the extremes of time and temperature expected for shipping and handling of proficiency panel samples, including 24 h at 37 degrees C and 2 weeks at temperatures ranging from ambient room temperature to -70 degrees C. The analytic test performance, including the reproducibility over the dynamic range of the assays, indicates that armored RNA can provide a noninfectious, quantifiable, and stable virus surrogate for specific assay training and proficiency test purposes. FAU - Hietala, S K AU - Hietala SK AD - California Animal Health and Food Safety Laboratory, University of California, Davis, 95616, USA. skhietala@ucdavis.edu FAU - Crossley, B M AU - Crossley BM LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - J Clin Microbiol JT - Journal of clinical microbiology JID - 7505564 RN - 0 (RNA, Viral) SB - IM MH - Laboratories/*standards MH - Quality Control MH - RNA, Viral/*analysis/genetics MH - Reference Standards MH - Reverse Transcriptase Polymerase Chain Reaction/*methods/standards MH - Sensitivity and Specificity PMC - PMC1351936 EDAT- 2006/01/05 09:00 MHDA- 2006/03/22 09:00 PMCR- 2006/05/01 CRDT- 2006/01/05 09:00 PHST- 2006/01/05 09:00 [pubmed] PHST- 2006/03/22 09:00 [medline] PHST- 2006/01/05 09:00 [entrez] PHST- 2006/05/01 00:00 [pmc-release] AID - 44/1/67 [pii] AID - 1015-05 [pii] AID - 10.1128/JCM.44.1.67-70.2006 [doi] PST - ppublish SO - J Clin Microbiol. 2006 Jan;44(1):67-70. doi: 10.1128/JCM.44.1.67-70.2006. PMID- 34696087 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211029 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 20 DP - 2021 Oct 16 TI - In-Tire Distributed Optical Fiber (DOF) Sensor for the Load Assessment of Light Vehicles in Static Conditions. LID - 10.3390/s21206874 [doi] LID - 6874 AB - Modern vehicles are using control and safety driving algorithms fed by various evaluations such as wheel speeds or road environmental conditions. Wheel load evaluation could be useful for such algorithms, particularly for extreme vehicle loading or uneven loads. For now, smart tires are only equipped by tire pressure monitoring systems (TPMS) and temperature sensors. Manufacturers are still working on in-tire sensors, such as load sensors, to create the next generation of smart tires. The present work aims at demonstrating that a static tire instrumented with an internal optical fiber allows the wheel load estimation for every wheel angular position. Experiments have been carried out with a static tire loaded with a hydraulic press and instrumented with both an internal optical fiber and an embedded laser. Load estimation is performed both from tire deflection and contact patch length evaluations. For several applied loads from 2800 to 4800 N, optical fiber load estimation is realized with a relative error of 1% to 3%, almost as precisely as that with the embedded laser, but with the advantage of the load estimation regardless of the wheel angular position. In perspective, the developed methodology based on an in-tire optical fiber could be used for continuous wheel load estimation for moving vehicles, benefiting control and on-board safety systems. FAU - Fontaine, Martin AU - Fontaine M AUID- ORCID: 0000-0002-7283-2098 AD - COSYS-SII, Université Gustave Eiffel, IFSTTAR, 44344 Bouguenais, France. AD - CAPTELS Society, 34270 Saint-Mathieu-de-Tréviers, France. FAU - Coiret, Alex AU - Coiret A AUID- ORCID: 0000-0002-6207-3286 AD - COSYS-SII, Université Gustave Eiffel, IFSTTAR, 44344 Bouguenais, France. FAU - Cesbron, Julien AU - Cesbron J AUID- ORCID: 0000-0002-7182-909X AD - UMRAE, Université Gustave Eiffel, IFSTTAR, CEREMA, 44344 Bouguenais, France. FAU - Baltazart, Vincent AU - Baltazart V AD - COSYS-SII, Université Gustave Eiffel, IFSTTAR, 44344 Bouguenais, France. FAU - Bétaille, David AU - Bétaille D AD - COSYS-SII, Université Gustave Eiffel, IFSTTAR, 44344 Bouguenais, France. LA - eng PT - Journal Article DEP - 20211016 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC8537413 OTO - NOTNLM OT - fiber optical OT - intelligent tire OT - load evaluation OT - tire contact patch length OT - wheel load COIS- The authors declare no conflict of interest. EDAT- 2021/10/27 06:00 MHDA- 2021/10/27 06:01 PMCR- 2021/10/16 CRDT- 2021/10/26 01:01 PHST- 2021/09/13 00:00 [received] PHST- 2021/10/08 00:00 [revised] PHST- 2021/10/11 00:00 [accepted] PHST- 2021/10/26 01:01 [entrez] PHST- 2021/10/27 06:00 [pubmed] PHST- 2021/10/27 06:01 [medline] PHST- 2021/10/16 00:00 [pmc-release] AID - s21206874 [pii] AID - sensors-21-06874 [pii] AID - 10.3390/s21206874 [doi] PST - epublish SO - Sensors (Basel). 2021 Oct 16;21(20):6874. doi: 10.3390/s21206874. PMID- 31754844 OWN - NLM STAT- MEDLINE DCOM- 20200526 LR - 20200526 IS - 1539-0829 (Electronic) IS - 1534-4827 (Linking) VI - 19 IP - 12 DP - 2019 Nov 21 TI - Lowering Targeted Atherogenic Lipoprotein Cholesterol Goals for Patients at "Extreme" ASCVD Risk. PG - 146 LID - 10.1007/s11892-019-1246-y [doi] AB - PURPOSE OF REVIEW: To review randomized interventional clinical and imaging trials that support lower targeted atherogenic lipoprotein cholesterol goals in "extreme" and "very high" atherosclerotic cardiovascular disease (ASCVD) risk settings. Major atherosclerotic cardiovascular event (MACE) prevention among the highest risk patients with ASCVD requires aggressive management of global risks, including lowering of the fundamental atherogenic apolipoprotein B-associated lipoprotein cholesterol particles [i.e., triglyceride-rich lipoprotein remnant cholesterol, low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a)]. LDL-C has been the long-time focus of imaging studies and randomized clinical trials (RCTs). The 2004 adult treatment panel (ATP-III) update recognized that the long-standing targeted LDL-C goal of < 100 mg/dL potentially fostered substantial undertreatment of the very highest coronary heart disease (CHD) risk individuals and was lowered to < 70 mg/dL as an "optional" goal for "very high" 10-year CHD [CHD death + myocardial infarction (MI)] risk exceeding 20%. This evidence-based guideline change was supported by the observed benefits demonstrated in the high-risk primary and secondary prevention populations in the Heart Protection Study (HPS), the acute coronary syndrome (ACS) population in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 trial (PROVE-IT), and the secondary prevention population in the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) intravascular ultrasound (IVUS) study. Subsequent national and international guidelines maintained a targeted LDL-C goal < 70 mg/dL, or a threshold for management of > 70 mg/dL for patients with CHD, CHD risk equivalency, or ASCVD. RECENT FINDINGS: Subgroup or meta-analyses of several RCTs, IVUS imaging studies, and the ACS population in IMProved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) supported the evidence-based 2017 American Association Clinical Endocrinologist (AACE) guideline change establishing a targeted LDL-C goal < 55 mg/dL, non-HDL-C < 80 mg/dl, and apolipoprotein B (apo B) < 70 mg/dL for patients at "Extreme" ASCVD risk, i.e., 10-year 3-point-MACE-composite (CV death, non-fatal MI, or ischemic stroke) risk exceeding 30%. Moreover, with no recognized lower-limit-associated intolerance or safety issues, even more intensive lowering of atherogenic cholesterol levels is supported by the following evidence base: (1) analysis of eight high-intensity statin-based prospective secondary prevention IVUS atheroma volume regression trials; (2) a distribution analysis of on-treatment, ezetimibe and background-statin, of the very low LDL-C levels reached and CVD event risk in the IMPROVE-IT ACS population; (3) the secondary prevention Global Assessment of Pl\aque Regression With a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV) on background-statin; and (4) the secondary prevention population of Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk (FOURIER). By example, in FOURIER, the population on background-statin at a baseline median 92 mg/dL achieved median LDL-C level of 30 mg/dL and non-HDL-C to < 65 mg/dl, and apo B to < 50 mg/dL, and subgroup and post hoc analyses all demonstrated additional ASCVD event reduction benefits as LDL-C was further reduced. The level of ASCVD risk determines the degree, urgency, and persistence in global risk management, including fundamental atherogenic lipoprotein cholesterol particle lowering. "Extreme" risk patients may require extremely low targeted LDL-C, non-HDL-C and apo B goals; such efforts, implied by more recent interventional trials and analyses, are aimed at maximal atheroma plaque regression, stabilization, and MACE event reduction with the aspiration of improved quality lifespan. FAU - Rosenblit, Paul D AU - Rosenblit PD AD - Department of Medicine, Division of Endocrinology, Diabetes, & Metabolism, University California, Irvine (UCI), School of Medicine, Irvine, CA, 92697, USA. pdrosenblit@yahoo.com. AD - Diabetes Out-Patient Clinic, UCI Medical Center, Orange, CA, 92868, USA. pdrosenblit@yahoo.com. AD - Diabetes/Lipid Management & Research Center, 18821 Delaware St., Suite 202, Huntington Beach, CA, 92648, USA. pdrosenblit@yahoo.com. LA - eng PT - Journal Article PT - Review DEP - 20191121 PL - United States TA - Curr Diab Rep JT - Current diabetes reports JID - 101093791 RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) RN - 0 (Hypolipidemic Agents) RN - 0 (Lipids) RN - 0 (Lipoproteins) RN - 0 (Triglycerides) RN - 0 (lipoprotein cholesterol) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Adult MH - Atherosclerosis/*blood/etiology/prevention & control MH - Cholesterol/*adverse effects/blood/metabolism MH - Goals MH - Humans MH - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use MH - Hypolipidemic Agents/*therapeutic use MH - Lipids/*blood MH - Lipoproteins/*adverse effects/blood/metabolism MH - Prospective Studies MH - Randomized Controlled Trials as Topic MH - Triglycerides/blood OTO - NOTNLM OT - 3-point-MACE-composite (CV death, non-fatal MI or ischemic stroke) risk OT - ASCVD risk assessment OT - Atherogenic lipoprotein cholesterol particle-lowering OT - Extreme risk OT - LDL-C-lowering, non-HDL-C, apolipoprotein B OT - Secondary prevention OT - Very high risk EDAT- 2019/11/23 06:00 MHDA- 2020/05/27 06:00 CRDT- 2019/11/23 06:00 PHST- 2019/11/23 06:00 [entrez] PHST- 2019/11/23 06:00 [pubmed] PHST- 2020/05/27 06:00 [medline] AID - 10.1007/s11892-019-1246-y [pii] AID - 10.1007/s11892-019-1246-y [doi] PST - epublish SO - Curr Diab Rep. 2019 Nov 21;19(12):146. doi: 10.1007/s11892-019-1246-y. PMID- 34292598 OWN - NLM STAT- MEDLINE DCOM- 20211018 LR - 20211018 IS - 1469-8137 (Electronic) IS - 0028-646X (Linking) VI - 232 IP - 3 DP - 2021 Nov TI - Repeated extreme heatwaves result in higher leaf thermal tolerances and greater safety margins. PG - 1212-1225 LID - 10.1111/nph.17640 [doi] AB - The frequency and severity of heatwave events are increasing, exposing species to conditions beyond their physiological limits. Species respond to heatwaves in different ways, however it remains unclear if plants have the adaptive capacity to successfully respond to hotter and more frequent heatwaves. We exposed eight tree populations from two climate regions grown under cool and warm temperatures to repeated heatwave events of moderate (40°C) and extreme (46°C) severity to assess adaptive capacity to heatwaves. Leaf damage and maximum quantum efficiency of photosystem II (F(v) /F(m) ) were significantly impacted by heatwave severity and growth temperatures, respectively; populations from a warm-origin avoided damage under moderate heatwaves compared to those from a cool-origin, indicating a degree of local adaptation. We found that plasticity to heatwave severity and repeated heatwaves contributed to enhanced thermal tolerance and lower leaf temperatures(,) leading to greater thermal safety margins (thermal tolerance minus leaf temperature) in a second heatwave. Notably, while we show that adaptation and physiological plasticity are important factors affecting plant adaptive capacity to thermal stress, plasticity of thermal tolerances and thermal safety margins provides the opportunity for trees to persist among fluctuating heatwave exposures. CI - © 2021 The Authors. New Phytologist © 2021 New Phytologist Foundation. FAU - Ahrens, Collin W AU - Ahrens CW AUID- ORCID: 0000-0002-0614-9928 AD - Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia. FAU - Challis, Anthea AU - Challis A AUID- ORCID: 0000-0002-3814-9850 AD - Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia. FAU - Byrne, Margaret AU - Byrne M AUID- ORCID: 0000-0002-7197-5409 AD - Biodiversity and Conservation Science, Department of Biodiversity, Conservation and Attractions, Bentley Delivery Centre, Locked Bag 104, Bentley, WA, 6983, Australia. FAU - Leigh, Andrea AU - Leigh A AUID- ORCID: 0000-0003-3568-2606 AD - School of Life Sciences, University of Technology Sydney, PO Box 123, Broadway, NSW, 2007, Australia. FAU - Nicotra, Adrienne B AU - Nicotra AB AUID- ORCID: 0000-0001-6578-369X AD - Research School of Biology, Australian National University, Canberra, ACT, 2601, Australia. FAU - Tissue, David AU - Tissue D AUID- ORCID: 0000-0002-8497-2047 AD - Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia. FAU - Rymer, Paul AU - Rymer P AUID- ORCID: 0000-0003-0988-4351 AD - Hawkesbury Institute for the Environment, Western Sydney University, Richmond, NSW, 2753, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210830 PL - England TA - New Phytol JT - The New phytologist JID - 9882884 SB - IM MH - Acclimatization MH - Climate MH - *Plant Leaves MH - Temperature MH - *Trees OTO - NOTNLM OT - Eucalyptus OT - acclimation OT - adaptive capacity OT - climate change OT - plasticity EDAT- 2021/07/23 06:00 MHDA- 2021/10/21 06:00 CRDT- 2021/07/22 12:37 PHST- 2021/04/25 00:00 [received] PHST- 2021/07/15 00:00 [accepted] PHST- 2021/07/23 06:00 [pubmed] PHST- 2021/10/21 06:00 [medline] PHST- 2021/07/22 12:37 [entrez] AID - 10.1111/nph.17640 [doi] PST - ppublish SO - New Phytol. 2021 Nov;232(3):1212-1225. doi: 10.1111/nph.17640. Epub 2021 Aug 30. PMID- 30959256 OWN - NLM STAT- MEDLINE DCOM- 20200123 LR - 20200123 IS - 1878-8769 (Electronic) IS - 1878-8750 (Linking) VI - 127 DP - 2019 Jul TI - Safety Analysis of Two Anterior Lateral Lumbar Interbody Fusions at the Initial Stage of Learning Curve. PG - e901-e909 LID - S1878-8750(19)30975-1 [pii] LID - 10.1016/j.wneu.2019.03.294 [doi] AB - OBJECTIVE: Until now, there were few studies on the safety analysis of oblique lumbar interbody fusion (OLIF) and extreme lateral interbody fusion (XLIF) in the initial stage of learning curve. The purpose of this study was to find out the safety differences between the 2 minimally invasive fusion methods in the initial stage of learning curve and to provide reference for beginners. METHODS: We retrospectively collected the first 30 cases of lumbar degenerative disease with OLIF or XLIF in our center since June 2014. Patients were divided into group OLIF and group XLIF according to different operative methods. The clinical efficacy and complications of the 2 groups were compared. A P <0.05 was statistically significant. RESULTS: Group XLIF were aged 37-74 years (mean 58.4 years) and group OLIF were aged 39-71 years (mean 56.1 years). There were no significant differences between the 2 groups in age, sex, operation time, intraoperative bleeding volume, operation segment, and follow-up time. The incidence of complications in group XLIF was significantly lower than that in group OLIF (10% vs. 33.3%; P = 0.028). CONCLUSIONS: OLIF has a higher risk of neurovascular injury in the initial stage of learning. By contrast, the XLIF approach is simple and the incidence of complications is relatively low. Therefore, we believed that XLIF is more acceptable in the initial stage of anterolateral lumbar interbody fusion. CI - Copyright © 2019 Elsevier Inc. All rights reserved. FAU - Li, Jiaqi AU - Li J AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Wang, Xianzheng AU - Wang X AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Sun, Yapeng AU - Sun Y AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Fei AU - Zhang F AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Gao, Yuan AU - Gao Y AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Li, Zeyang AU - Li Z AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Ding, Wenyuan AU - Ding W AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Shen, Yong AU - Shen Y AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address: zhangweiat430@sina.com. LA - eng PT - Journal Article DEP - 20190406 PL - United States TA - World Neurosurg JT - World neurosurgery JID - 101528275 SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - *Learning Curve MH - Lumbar Vertebrae/*surgery MH - Lumbosacral Region/surgery MH - Male MH - Middle Aged MH - Operative Time MH - Postoperative Complications/etiology MH - Retrospective Studies MH - Spinal Fusion/methods MH - *Treatment Outcome MH - Vascular System Injuries/*etiology OTO - NOTNLM OT - Complication OT - Extreme lateral interbody fusion OT - Lumbar degenerative disease OT - Oblique lumbar interbody fusion EDAT- 2019/04/09 06:00 MHDA- 2020/01/24 06:00 CRDT- 2019/04/09 06:00 PHST- 2018/12/23 00:00 [received] PHST- 2019/03/28 00:00 [revised] PHST- 2019/03/29 00:00 [accepted] PHST- 2019/04/09 06:00 [pubmed] PHST- 2020/01/24 06:00 [medline] PHST- 2019/04/09 06:00 [entrez] AID - S1878-8750(19)30975-1 [pii] AID - 10.1016/j.wneu.2019.03.294 [doi] PST - ppublish SO - World Neurosurg. 2019 Jul;127:e901-e909. doi: 10.1016/j.wneu.2019.03.294. Epub 2019 Apr 6. PMID- 26683933 OWN - NLM STAT- MEDLINE DCOM- 20160426 LR - 20221005 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 94 IP - 50 DP - 2015 Dec TI - Scaffold-free Three-dimensional Graft From Autologous Adipose-derived Stem Cells for Large Bone Defect Reconstruction: Clinical Proof of Concept. PG - e2220 LID - 10.1097/MD.0000000000002220 [doi] LID - e2220 AB - Long bone nonunion in the context of congenital pseudarthrosis or carcinologic resection (with intercalary bone allograft implantation) is one of the most challenging pathologies in pediatric orthopedics. Autologous cancellous bone remains the gold standard in this context of long bone nonunion reconstruction, but with several clinical limitations. We then assessed the feasibility and safety of human autologous scaffold-free osteogenic 3-dimensional (3D) graft (derived from autologous adipose-derived stem cells [ASCs]) to cure a bone nonunion in extreme clinical and pathophysiological conditions. Human ASCs (obtained from subcutaneous adipose tissue of 6 patients and expanded up to passage 4) were incubated in osteogenic media and supplemented with demineralized bone matrix to obtain the scaffold-free 3D osteogenic structure as confirmed in vitro by histomorphometry for osteogenesis and mineralization. The 3D "bone-like" structure was finally transplanted for 3 patients with bone tumor and 3 patients with bone pseudarthrosis (2 congenital, 1 acquired) to assess the clinical feasibility, safety, and efficacy. Although minor clones with structural aberrations (aneuploidies, such as tri or tetraploidies or clonal trisomy 7 in 6%-20% of cells) were detected in the undifferentiated ASCs at passage 4, the osteogenic differentiation significantly reduced these clonal anomalies. The final osteogenic product was stable, did not rupture with forceps manipulation, did not induce donor site morbidity, and was easily implanted directly into the bone defect. No acute (<3 mo) side effects, such as impaired wound healing, pain, inflammatory reaction, and infection, or long-term side effects, such as tumor development, were associated with the graft up to 4 years after transplantation. We report for the first time that autologous ASC can be fully differentiated into a 3D osteogenic-like implant without any scaffold. We demonstrated that this engineered tissue can safely promote osteogenesis in extreme conditions of bone nonunions with minor donor site morbidity and no oncological side effects. FAU - Dufrane, Denis AU - Dufrane D AD - From the Endocrine Cell Therapy, Center of Tissue and Cell Therapy, Cliniques Universitaires Saint-Luc, Brussels, Belgium (DD, WA, NA); Orthopedic Surgery Service, Department of Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium (P-LD, CD); and Center for Human Genetics, Cliniques Universitaires Saint-Luc - Université Catholique de Louvain, Brussels, Belgium (HAP). FAU - Docquier, Pierre-Louis AU - Docquier PL FAU - Delloye, Christian AU - Delloye C FAU - Poirel, Hélène A AU - Poirel HA FAU - André, Wivine AU - André W FAU - Aouassar, Najima AU - Aouassar N LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Adipocytes/*cytology MH - Adolescent MH - Bone Neoplasms/pathology/surgery MH - Cell Differentiation MH - Child MH - Feasibility Studies MH - Female MH - Humans MH - Male MH - Osteosarcoma/pathology/surgery MH - Pseudarthrosis/etiology/pathology/*therapy MH - Stem Cells MH - Tissue Engineering/*methods MH - Tissue Scaffolds PMC - PMC5058905 COIS- The authors have no conflicts of interest to disclose. EDAT- 2015/12/20 06:00 MHDA- 2016/04/27 06:00 PMCR- 2015/12/18 CRDT- 2015/12/20 06:00 PHST- 2015/12/20 06:00 [entrez] PHST- 2015/12/20 06:00 [pubmed] PHST- 2016/04/27 06:00 [medline] PHST- 2015/12/18 00:00 [pmc-release] AID - 00005792-201512150-00028 [pii] AID - 10.1097/MD.0000000000002220 [doi] PST - ppublish SO - Medicine (Baltimore). 2015 Dec;94(50):e2220. doi: 10.1097/MD.0000000000002220. PMID- 21746718 OWN - NLM STAT- MEDLINE DCOM- 20111013 LR - 20171116 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 128 IP - 2 DP - 2011 Aug TI - Mercury content of blood transfusions for infants with extremely low birth weight. PG - 331-4 LID - 10.1542/peds.2010-3712 [doi] AB - OBJECTIVES: To assess whether blood transfusions for infants with birth weights of 1000 g or less are a source of mercury and whether any mercury delivered through the transfusion is above the currently set oral reference dose. PATIENTS AND METHODS: We studied an observational cohort. Inclusion criteria included birth weight 1000 g or less and receipt of 1 or more packed red blood cell transfusions. Packed red blood cell units were tested prospectively for mercury levels. The quantity of transfused mercury was calculated on the basis of transfused volume and packed red blood cell mercury level. The resulting mercury level was compared with the reference dose as set by the Agency for Toxic Substances and Disease Registry, the World Health Organization, and the US Environmental Protection Agency. RESULTS: Thirty-seven infants (birth weight: 736 ± 157 g; gestational age: 25.5 ± 1.5 weeks) met the inclusion criteria. A total of 325 transfusions from 49 packed red blood cell units were administered. Mercury was detected in 40 units. The average mercury level in a packed red blood cell unit was 1.9 ± 2.6 μg/L (median: 0.9 μg/L [interquartile range: 0.3-2.5]). None of the infants received any mercury above the reference dose set by the Agency for Toxic Substances and Disease Registry and the World Health Organization. Twelve infants received 1 transfusion, and 5 infants received 2 transfusions above the Environmental Protection Agency reference dose during their entire hospitalization. CONCLUSIONS: Packed red blood cells are a source of mercury for infants. However, the amount delivered is low compared with currently set safety levels. The episodes in which mercury intake exceeded the reference dose were rare. However, without long-term follow-up, no conclusions can be made about the cognitive implications of these episodes. FAU - Elabiad, Mohamad T AU - Elabiad MT AD - Division of Neonatology, Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA. melabiad@uthsc.edu FAU - Hook, Rebecca E AU - Hook RE LA - eng PT - Comparative Study PT - Journal Article DEP - 20110711 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 RN - FXS1BY2PGL (Mercury) SB - IM MH - Anemia, Neonatal/blood/therapy MH - Blood Safety/adverse effects/*standards MH - *Blood Transfusion MH - Cohort Studies MH - Humans MH - Infant, Extremely Low Birth Weight/*blood MH - Infant, Newborn MH - Mercury/adverse effects/analysis/*blood MH - Prospective Studies MH - Retrospective Studies MH - Transfusion Reaction EDAT- 2011/07/13 06:00 MHDA- 2011/10/14 06:00 CRDT- 2011/07/13 06:00 PHST- 2011/07/13 06:00 [entrez] PHST- 2011/07/13 06:00 [pubmed] PHST- 2011/10/14 06:00 [medline] AID - peds.2010-3712 [pii] AID - 10.1542/peds.2010-3712 [doi] PST - ppublish SO - Pediatrics. 2011 Aug;128(2):331-4. doi: 10.1542/peds.2010-3712. Epub 2011 Jul 11. PMID- 30297540 OWN - NLM STAT- MEDLINE DCOM- 20190409 LR - 20221207 IS - 1759-8486 (Electronic) IS - 1759-8478 (Linking) VI - 11 IP - 3 DP - 2019 Mar TI - Vertebral body stent augmentation to reconstruct the anterior column in neoplastic extreme osteolysis. PG - 313-318 LID - 10.1136/neurintsurg-2018-014231 [doi] AB - BACKGROUND: Extensive lytic lesions of the vertebral body (VB) increase risk of fracture and instability and require stabilization of the anterior column. Vertebral augmentation is an accepted treatment option, but when osteolysis has extensively destroyed the VB cortical boundaries (a condition herein defined as 'extreme osteolysis'), the risk of cement leakage and/or insufficient filling is high. Vertebral body stents (VBSs) might allow partial restoration of VB height, cement containment, and reinforcement, but their use in extreme osteolysis has not been investigated. OBJECTIVE: To assess retrospectively the feasibility and safety of VBS augmentation in patients with 'extreme osteolysis' of the VB. METHODS: We retrospectively analyzed 41 treated vertebrae (from T1 to L5). VB reconstruction was assessed on postprocedure CT images and rated on a qualitative 4-point scale (poor-fair-good-excellent). Clinical and radiological follow-up was performed at 1 month and thereafter at intervals in accordance with oncological protocols. RESULTS: VBS augmentation was performed at 12 lumbar and 29 thoracic levels, with bilateral VBS in 23/41. VB reconstruction was judged satisfactory (good or excellent) in 37/41 (90%) of levels. Bilateral VBS received higher scores than unilateral (p=0.057, Pearson's X(2)). We observed no periprocedural complications. Cement leaks (epidural or foraminal) occurred at 5/41 levels (12.2%) without clinical consequences. Follow-up data were available for 27/29 patients, extending beyond 6 months for 20 patients (7-28 months, mean 15.3 months). VBS implant stability was observed in 40/41 cases (97.5%). CONCLUSIONS: Our results support the use of VBS as a minimally invasive, safe and effective option for reconstructing the anterior column in prominent VB osteolysis. CI - © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Cianfoni, Alessandro AU - Cianfoni A AD - Department of Neuroradiology, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland. AD - Department of Interventional and Diagnostic Neuroradiology, Inselspital, University Hospital of Bern, Bern, Switzerland. FAU - Distefano, Daniela AU - Distefano D AD - Department of Neuroradiology, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland. FAU - Pravatà, Emanuele AU - Pravatà E AD - Department of Neuroradiology, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland. FAU - Espeli, Vittoria AU - Espeli V AD - Department of Neuro-oncology, Oncology Institute of Southern Switzerland, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland. FAU - Pesce, Gianfranco AU - Pesce G AD - Department of Neuro-oncology, Oncology Institute of Southern Switzerland, Ospedale Regionale di Bellinzona e Valli, Bellinzona, Switzerland. FAU - Mordasini, Pasquale AU - Mordasini P AD - Department of Interventional and Diagnostic Neuroradiology, Inselspital, University Hospital of Bern, Bern, Switzerland. FAU - La Barbera, Luigi AU - La Barbera L AD - Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Milan, Italy. FAU - Scarone, Pietro AU - Scarone P AD - Department of Neurosurgery, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Lugano, Switzerland. FAU - Bonaldi, Giuseppe AU - Bonaldi G AD - Department of Neuroradiology, Papa Giovanni XXIII Hospital, Bergamo, Italy. LA - eng PT - Journal Article DEP - 20181008 PL - England TA - J Neurointerv Surg JT - Journal of neurointerventional surgery JID - 101517079 RN - 0 (Bone Cements) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Bone Cements MH - Female MH - Humans MH - Lumbar Vertebrae/diagnostic imaging/*surgery MH - Male MH - Middle Aged MH - Osteolysis/diagnostic imaging/*surgery MH - Plastic Surgery Procedures/*methods MH - Retrospective Studies MH - Spinal Fractures/diagnostic imaging/prevention & control MH - Spinal Neoplasms/diagnostic imaging/*surgery MH - *Stents MH - Thoracic Vertebrae/diagnostic imaging/*surgery MH - Treatment Outcome OTO - NOTNLM OT - metastatic OT - neoplasm OT - spine OT - stent COIS- Competing interests: None declared. EDAT- 2018/10/10 06:00 MHDA- 2019/04/10 06:00 CRDT- 2018/10/10 06:00 PHST- 2018/07/02 00:00 [received] PHST- 2018/08/15 00:00 [revised] PHST- 2018/08/17 00:00 [accepted] PHST- 2018/10/10 06:00 [pubmed] PHST- 2019/04/10 06:00 [medline] PHST- 2018/10/10 06:00 [entrez] AID - neurintsurg-2018-014231 [pii] AID - 10.1136/neurintsurg-2018-014231 [doi] PST - ppublish SO - J Neurointerv Surg. 2019 Mar;11(3):313-318. doi: 10.1136/neurintsurg-2018-014231. Epub 2018 Oct 8. PMID- 38526600 OWN - NLM STAT- MEDLINE DCOM- 20240729 LR - 20240829 IS - 1432-1254 (Electronic) IS - 0020-7128 (Print) IS - 0020-7128 (Linking) VI - 68 IP - 6 DP - 2024 Jun TI - The effects of extreme heat on human health in tropical Africa. PG - 1015-1033 LID - 10.1007/s00484-024-02650-4 [doi] AB - This review examines high-quality research evidence that synthesises the effects of extreme heat on human health in tropical Africa. Web of Science (WoS) was used to identify research articles on the effects extreme heat, humidity, Wet-bulb Globe Temperature (WBGT), apparent temperature, wind, Heat Index, Humidex, Universal Thermal Climate Index (UTCI), heatwave, high temperature and hot climate on human health, human comfort, heat stress, heat rashes, and heat-related morbidity and mortality. A total of 5, 735 articles were initially identified, which were reduced to 100 based on a set of inclusion and exclusion criteria. The review discovered that temperatures up to 60°C have been recorded in the region and that extreme heat has many adverse effects on human health, such as worsening mental health in low-income adults, increasing the likelihood of miscarriage, and adverse effects on well-being and safety, psychological behaviour, efficiency, and social comfort of outdoor workers who spend long hours performing manual labour. Extreme heat raises the risk of death from heat-related disease, necessitating preventative measures such as adaptation methods to mitigate the adverse effects on vulnerable populations during hot weather. This study highlights the social inequalities in heat exposure and adverse health outcomes. CI - © 2024. The Author(s). FAU - Kunda, Joshua Jonah AU - Kunda JJ AD - School of Geography, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. jonahkunda@gmail.com. FAU - Gosling, Simon N AU - Gosling SN AD - School of Geography, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. FAU - Foody, Giles M AU - Foody GM AD - School of Geography, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. LA - eng PT - Journal Article PT - Review DEP - 20240325 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - Tropical Climate MH - Humans MH - Africa MH - *Extreme Heat MH - *Climate Change MH - *Heat Stress Disorders/mortality MH - Seasons PMC - PMC11108931 OTO - NOTNLM OT - Climate change. Extreme heat. Human health. Tropical Africa EDAT- 2024/03/25 12:45 MHDA- 2024/05/21 12:45 PMCR- 2024/03/25 CRDT- 2024/03/25 12:04 PHST- 2023/08/12 00:00 [received] PHST- 2024/03/04 00:00 [accepted] PHST- 2024/02/28 00:00 [revised] PHST- 2024/05/21 12:45 [medline] PHST- 2024/03/25 12:45 [pubmed] PHST- 2024/03/25 12:04 [entrez] PHST- 2024/03/25 00:00 [pmc-release] AID - 10.1007/s00484-024-02650-4 [pii] AID - 2650 [pii] AID - 10.1007/s00484-024-02650-4 [doi] PST - ppublish SO - Int J Biometeorol. 2024 Jun;68(6):1015-1033. doi: 10.1007/s00484-024-02650-4. Epub 2024 Mar 25. PMID- 38971452 OWN - NLM STAT- MEDLINE DCOM- 20241023 LR - 20241023 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 67 IP - 5 DP - 2024 Nov TI - Reasons for Gun Ownership Among Demographically Diverse New and Prior Gun Owners. PG - 730-739 LID - S0749-3797(24)00226-5 [pii] LID - 10.1016/j.amepre.2024.06.026 [doi] AB - INTRODUCTION: Pandemic-era social and political tensions may have accelerated pre-existing trends in gun owner diversification and shifts toward protection from people as a primary reason for gun ownership. Specific ownership motivations may shape storage behaviors, use patterns, policy support, and perceptions of safety. This study's objective was to assess the importance of specific reasons for owning guns, including protection from whom and in what circumstances, among demographic subgroups of new and prior gun owners. METHODS: From January 4, 2023 to February 6, 2023, the National Survey of Gun Policy was fielded among a nationally representative sample of U.S. adults (N=3,096), including gun owners (n=1,002). Respondents rated the importance of 10 potential reasons for gun ownership, including at-home protection, out-of-home protection, protection in ideologic conflict, and hunting or recreation. In 2023-2024, respondents' self-report of important and highly important reasons for gun ownership were compared across political affiliation, race, ethnicity, age, sex, location, income, education, and recency of first purchase. RESULTS: Majorities of gun owners from all demographic groups cited at-home protection, out-of-home protection, and hunting or recreation as very or extremely important. At least 10% of every demographic group endorsed at least 1 ideologic reason as extremely important. Newer gun owners more frequently endorsed multiple important reasons. CONCLUSIONS: Concurrent, strongly held motivations may produce ambivalence or resistance to public health messaging that narrowly focuses on preventing violent firearm-related injury. Permissive firearm policies may compound behavioral ambivalence, exacerbating conditions that threaten collective safety and civic expression. These conditions call for more nuanced, multidimensional, societal efforts to assure collective safety. CI - Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ward, Julie A AU - Ward JA AD - Department of Medicine, Health, and Society, Vanderbilt College of Arts and Science, Nashville, Tennessee. Electronic address: Julie.ward@vanderbilt.edu. FAU - Valek, Rebecca A AU - Valek RA AD - Oregon Health & Science University, Portland State University School of Public Health, Portland, Oregon; Center for Gun Violence Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Jones, Vanya C AU - Jones VC AD - Center for Gun Violence Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Crifasi, Cassandra K AU - Crifasi CK AD - Center for Gun Violence Solutions, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. LA - eng PT - Journal Article DEP - 20240704 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 SB - IM MH - Humans MH - *Firearms/statistics & numerical data/legislation & jurisprudence MH - *Ownership/statistics & numerical data MH - Male MH - Female MH - Adult MH - United States MH - Middle Aged MH - Young Adult MH - Surveys and Questionnaires MH - Motivation MH - Adolescent MH - Aged EDAT- 2024/07/07 00:41 MHDA- 2024/10/24 00:22 CRDT- 2024/07/06 19:29 PHST- 2024/03/01 00:00 [received] PHST- 2024/06/27 00:00 [revised] PHST- 2024/06/30 00:00 [accepted] PHST- 2024/10/24 00:22 [medline] PHST- 2024/07/07 00:41 [pubmed] PHST- 2024/07/06 19:29 [entrez] AID - S0749-3797(24)00226-5 [pii] AID - 10.1016/j.amepre.2024.06.026 [doi] PST - ppublish SO - Am J Prev Med. 2024 Nov;67(5):730-739. doi: 10.1016/j.amepre.2024.06.026. Epub 2024 Jul 4. PMID- 26983424 OWN - NLM STAT- MEDLINE DCOM- 20171206 LR - 20220409 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) VI - 25 IP - 5 DP - 2016 May TI - Comparison of the safety outcomes between two surgical approaches for anterior lumbar fusion surgery: anterior lumbar interbody fusion (ALIF) and extreme lateral interbody fusion (ELIF). PG - 1484-1521 LID - 10.1007/s00586-016-4407-6 [doi] AB - PURPOSE: To review the evidence on safety of anterior lumbar interbody fusion (ALIF) and extreme lateral transpsoas interbody fusion (ELIF) in the treatment of degenerative spinal disorders with an emphasis on the association between neuromonitoring and complications. METHODS: We performed a systematic literature search in the Cochrane (CENTRAL), MEDLINE, EMBASE and the FDA Medical Devices databases. We abstracted information on study design, sample size, population, procedure, number and location of involved levels, follow-up time and complications, as well as information on conflict of interest and source of funding. In addition, for ELIF we collected information on the use of neuromonitoring during the procedure. RESULTS: 34 publications were included in the review: 24 ELIF (all case series), 9 ALIF (8 randomized controlled trials and 1 case series) and one retrospective cohort that directly compared ELIF with ALIF. 18 out of 24 ELIF studies reported using neuromonitoring. The overall complication rate for ELIF was lower compared to ALIF without FDA reports (16.61 vs. 26.47 %, respectively). However, the rate of neurologic complications in ELIF was almost twice as high compared to ALIF without FDA reports (8.92 and 4.96 %, respectively). The rate of overall complications in ELIF studies that were reported using neuromonitoring was lower compared to the studies that did not report using neuromonitoring (16.34 vs. 21.74 %, respectively). CONCLUSION: Although the overall complications rate for ELIF was lower compared to ALIF, ELIF is associated with a greater risk of neurological complications compared to ALIF even when used with neuromonitoring. FAU - Härtl, Roger AU - Härtl R AD - Department of Neurological Surgery, Weill Cornell Brain and Spine Center, Weill Cornell Medical College, New York-Presbyterian Hospital, 525 East 68th Street, Box 99, New York, NY, 10021, USA. roh9005@med.cornell.edu. FAU - Joeris, Alexander AU - Joeris A AD - AO Clinical Investigation and Documentation, Dübendorf, Switzerland. FAU - McGuire, Robert A AU - McGuire RA AD - Department of Orthopedics and Rehabilitation, University of Mississippi Medical Center, Jackson, USA. LA - eng PT - Journal Article PT - Review DEP - 20160317 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM MH - Humans MH - Lumbar Vertebrae/*surgery MH - *Spinal Fusion/adverse effects/methods/statistics & numerical data MH - Treatment Outcome OTO - NOTNLM OT - Anterior lumbar interbody fusion (ALIF) OT - Degenerative disc disease (DDD) OT - Extreme lateral interbody fusion (ELIF) OT - Extreme lateral interbody fusion (XLIF) OT - Lumbar fusion surgery EDAT- 2016/03/18 06:00 MHDA- 2017/12/07 06:00 CRDT- 2016/03/18 06:00 PHST- 2014/10/01 00:00 [received] PHST- 2016/01/15 00:00 [accepted] PHST- 2016/01/11 00:00 [revised] PHST- 2016/03/18 06:00 [entrez] PHST- 2016/03/18 06:00 [pubmed] PHST- 2017/12/07 06:00 [medline] AID - 10.1007/s00586-016-4407-6 [pii] AID - 10.1007/s00586-016-4407-6 [doi] PST - ppublish SO - Eur Spine J. 2016 May;25(5):1484-1521. doi: 10.1007/s00586-016-4407-6. Epub 2016 Mar 17. PMID- 19995631 OWN - NLM STAT- MEDLINE DCOM- 20100104 LR - 20161125 IS - 1557-8275 (Electronic) IS - 0033-8389 (Linking) VI - 48 IP - 1 DP - 2010 Jan TI - Congenital thoracic vascular anomalies. PG - 85-115 LID - 10.1016/j.rcl.2009.09.004 [doi] AB - Congenital vascular anomalies of the thorax represent an important group of entities that can occur either in isolation or in association with different forms of congenital heart disease. It is extremely important that radiologists have a clear understanding of these entities, their imaging characteristics, and their clinical relevance. The imaging armamentarium available to diagnose these diverse conditions is ample, and has evolved from such traditional methods as chest radiography, barium esophagography, and angiography to new modalities that include echocardiography, multidetector row CT (MDCT), and MR imaging. These imaging modalities have added safety, speed, and superb resolution in diagnosis and, as in the case of MDCT, provide additional information about the airway and lung parenchyma, resulting in a more comprehensive examination with greater anatomic coverage. This article reviews the most important congenital thoracic vascular anomalies, their embryologic foundation, clinical presentation, and imaging characteristics, especially those of MDCT. FAU - Maldonado, José A AU - Maldonado JA AD - Cardiothoracic Imaging Section, Department of Diagnostic Radiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Henry, Travis AU - Henry T FAU - Gutiérrez, Fernando R AU - Gutiérrez FR LA - eng PT - Journal Article PT - Review PL - United States TA - Radiol Clin North Am JT - Radiologic clinics of North America JID - 0123703 SB - IM MH - Arteriovenous Malformations/*diagnostic imaging MH - Heart Defects, Congenital/complications/*diagnostic imaging MH - Humans MH - Thoracic Diseases/complications/*congenital/*diagnostic imaging MH - Tomography, X-Ray Computed/*methods RF - 69 EDAT- 2009/12/10 06:00 MHDA- 2010/01/05 06:00 CRDT- 2009/12/10 06:00 PHST- 2009/12/10 06:00 [entrez] PHST- 2009/12/10 06:00 [pubmed] PHST- 2010/01/05 06:00 [medline] AID - S0033-8389(09)00174-2 [pii] AID - 10.1016/j.rcl.2009.09.004 [doi] PST - ppublish SO - Radiol Clin North Am. 2010 Jan;48(1):85-115. doi: 10.1016/j.rcl.2009.09.004. PMID- 37931145 OWN - NLM STAT- MEDLINE DCOM- 20231115 LR - 20241102 IS - 1525-3163 (Electronic) IS - 0021-8812 (Print) IS - 0021-8812 (Linking) VI - 101 DP - 2023 Jan 3 TI - Compound bioengineering protein improves growth performance and intestinal health in broiler chickens under high-temperature conditions. LID - 10.1093/jas/skad370 [doi] LID - skad370 AB - In recent years, more frequent and prolonged periods of high ambient temperature in summer compromised poultry production worldwide. This study was conducted to investigate the effects of compound bioengineering protein (CBP) on the growth performance and intestinal health of broilers under high ambient temperatures. A total of 400 one-day-old Arbor Acres birds were randomly distributed into five treatment groups: control group (CON) with basal diet, or a basal diet supplemented with CBP 250, 500, 750, and 1,000 mg/kg, respectively. The trial lasted 42 d, all birds were raised at normal ambient temperature for the first 21 d and then subjected to the artificial hyperthermal condition with the temperature at 32 ± 2 °C and relative humidity at 60 ± 5% during 22 to 42 d. Dietary CBP supplementation improved the growth performance and serum antioxidant capacity (total antioxidant capacity and total superoxide dismutase), and decreased serum cortisol, aminotransferase, and alkaline phosphatase of broilers. Dietary CBP inclusion enhanced intestinal barrier function by promoting intestinal morphology and reducing intestinal permeability (diamine oxidase), increased the intestinal antioxidant capacity by elevating glutathione peroxidase activity in the duodenum, reducing malondialdehyde content in the jejunum. Dietary CBP supplementation also alleviated intestinal inflammation by decreasing interleukin (IL)-6 content in the jejunum and ileum, promoting IL-10 levels in the ileum, down-regulating the mRNA abundance of intestinal inflammatory-related genes interferon-gamma (IFN-γ) in the duodenum and up-regulating IL-10 in the jejunum. Additionally, CBP increased the population of total bacteria and Lactobacillus in cecal chyme. Collectively, dietary CBP inclusion exerts beneficial effects on the broilers, which are reflected by enhancing antioxidant capacity, promoting intestinal barrier function, ameliorating intestinal immune response, and regulating intestinal bacteria, thus improving the growth performance of broilers under high-temperature conditions. In general, 750 mg/kg CBP supplementation is more effective. CI - © The Author(s) 2023. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. FAU - Yin, Shenggang AU - Yin S AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Su, Liuzhen AU - Su L AD - College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China. FAU - Shao, Quanjun AU - Shao Q AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Fan, Zhiyong AU - Fan Z AD - College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China. FAU - Tang, Jiayong AU - Tang J AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Jia, Gang AU - Jia G AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Liu, Guangmang AU - Liu G AUID- ORCID: 0000-0003-2385-7528 AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Tian, Gang AU - Tian G AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Chen, Xiaoling AU - Chen X AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Cai, Jingyi AU - Cai J AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. FAU - Kang, Bo AU - Kang B AD - College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, Sichuan 611130, China. FAU - Zhao, Hua AU - Zhao H AD - Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education, of Ministry of Agriculture and Rural Affairs, of Sichuan Province, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu 611130, China. LA - eng PT - Journal Article PL - United States TA - J Anim Sci JT - Journal of animal science JID - 8003002 RN - 0 (Antioxidants) RN - 130068-27-8 (Interleukin-10) SB - IM MH - Animals MH - *Chickens/physiology MH - *Antioxidants/metabolism MH - Interleukin-10 MH - Temperature MH - Dietary Supplements/analysis MH - Diet/veterinary MH - Bioengineering MH - Animal Feed/analysis PMC - PMC10642727 OAB - Extreme high ambient temperature in summer occurs frequently around the world, which causes severe economic losses in the broiler industry, and impairs food safety. Improving the high-temperature resistance of broilers is beneficial to the sustainable development of the broiler industry. Dietary supplementation of anti-stress additives is an effective way to prevent high-temperature stress in broilers. Antimicrobial peptides are excellent anti-stress additives that exhibit multiple biological functions, such as against microbial infection, improving antioxidant capacity and immune function, and perfecting the intestinal health of broilers. In the present study, we added the compound bioengineering protein (CBP) (two bioengineering proteins containing functional fragments of antimicrobial peptides) in diets to investigate the potential protective effects of CBP for broilers under high temperatures. Our present results indicate that dietary CBP supplementation enhances the growth performance of broilers exposed to high temperatures. This improvement is attributed to the increased antioxidant capacity, improved intestinal barrier function, ameliorated intestinal immune function, and improved intestinal bacteria. These results provide a theoretical foundation for CBP utilization in diets to ameliorate growth performance and intestinal health of broilers under high temperatures. OABL- eng OTO - NOTNLM OT - broiler OT - compound bioengineering protein OT - growth performance OT - high temperature OT - intestinal health COIS- The authors declare no real or perceived conflicts of interest. EDAT- 2023/11/06 18:41 MHDA- 2023/11/15 06:42 PMCR- 2024/11/01 CRDT- 2023/11/06 15:43 PHST- 2023/08/01 00:00 [received] PHST- 2023/10/31 00:00 [accepted] PHST- 2023/11/15 06:42 [medline] PHST- 2023/11/06 18:41 [pubmed] PHST- 2023/11/06 15:43 [entrez] PHST- 2024/11/01 00:00 [pmc-release] AID - 7336819 [pii] AID - skad370 [pii] AID - 10.1093/jas/skad370 [doi] PST - ppublish SO - J Anim Sci. 2023 Jan 3;101:skad370. doi: 10.1093/jas/skad370. PMID- 39276501 OWN - NLM STAT- MEDLINE DCOM- 20241031 LR - 20241031 IS - 1618-0623 (Electronic) IS - 0944-5013 (Linking) VI - 289 DP - 2024 Dec TI - Elaborating the multifarious role of PGPB for sustainable food security under changing climate conditions. PG - 127895 LID - S0944-5013(24)00296-9 [pii] LID - 10.1016/j.micres.2024.127895 [doi] AB - Changing climate creates a challenge to agricultural sustainability and food security by changing patterns of parameters like increased UV radiation, rising temperature, altered precipitation patterns, and higher occurrence of extreme weather incidents. Plants are vulnerable to different abiotic stresses such as waterlogging, salinity, heat, cold, and drought in their natural environments. The prevailing agricultural management practices play a major role in the alteration of the Earth's climate by causing biodiversity loss, soil degradation through chemical and physical degradation, and pollution of water bodies. The extreme usage of pesticides and fertilizers leads to climate change by releasing greenhouse gases (GHGs) and depositing toxic substances in the soil. At present, there is an urgent need to address these abiotic stresses to achieve sustainable growth in agricultural production and fulfill the rising global food demand. Several types of bacteria that are linked with plants can increase plant resistance to stress and lessen the negative effects of environmental challenges. This review aims to explore the environmentally friendly capabilities and prospects of multi-trait plant growth-promoting bacteria (PGPB) in the alleviation of detrimental impacts of harsh environmental conditions on plants. CI - Copyright © 2024 Elsevier GmbH. All rights reserved. FAU - Patel, Margi AU - Patel M AD - Department of Life Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, India. Electronic address: margipatel307@gmail.com. FAU - Islam, Shaikhul AU - Islam S AD - Plant Pathology Division, Bangladesh Wheat and Maize Research Institute, Nashipur, Dinajpur 5200, Bangladesh. Electronic address: islamshaikhul2014@outlook.com. FAU - Glick, Bernard R AU - Glick BR AD - Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: glick.bernard@gmail.com. FAU - Vimal, Shobhit Raj AU - Vimal SR AD - Department of Botany, University of Allahabad, Prayagraj 211002, India. Electronic address: shobhitraj1512@gmail.com. FAU - Bhor, Sachin Ashok AU - Bhor SA AD - Laboratory of Plant Molecular Biology and Virology, Faculty of Agriculture, Ehime University, Matsuyama, Ehime, Japan. Electronic address: bhor.sach@gmail.com. FAU - Bernardi, Matteo AU - Bernardi M AD - Department of Life, Health and Environmental Sciences, University of L'Aquila, via Vetoio, Coppito 67100, Italy. Electronic address: matteo.bernardi3789@gmail.com. FAU - Johora, Fatema Tuj AU - Johora FT AD - Lincoln University, Department of Sustainable Agriculture, 1570 Baltimore Pike, PA 19352, USA. Electronic address: snigdhasumaiya2@gmail.com. FAU - Patel, Ashish AU - Patel A AD - Department of Life Sciences, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, India. Electronic address: uni.ashish@gmail.com. FAU - de Los Santos Villalobos, Sergio AU - de Los Santos Villalobos S AD - Instituto Tecnológico de Sonora, 5 de febrero 818 sur, Ciudad Obregón, Sonora 85000, Mexico. Electronic address: sergio.delossantos@itson.edu.mx. LA - eng PT - Journal Article PT - Review DEP - 20240907 PL - Germany TA - Microbiol Res JT - Microbiological research JID - 9437794 RN - 0 (Greenhouse Gases) RN - 0 (Soil) RN - 0 (Fertilizers) SB - IM MH - *Climate Change MH - *Soil Microbiology MH - *Bacteria/metabolism MH - *Food Security MH - *Agriculture/methods MH - *Stress, Physiological MH - Plants MH - Plant Development MH - Greenhouse Gases/metabolism MH - Soil/chemistry MH - Biodiversity MH - Crops, Agricultural/growth & development/microbiology MH - Fertilizers/analysis OTO - NOTNLM OT - Climate change OT - Environmental stresses OT - Food safety OT - PGPB OT - Sustainable agriculture COIS- Declaration of Competing Interest The authors declare no conflict of interest. EDAT- 2024/09/15 14:09 MHDA- 2024/11/01 00:22 CRDT- 2024/09/14 18:04 PHST- 2024/06/25 00:00 [received] PHST- 2024/08/30 00:00 [revised] PHST- 2024/09/01 00:00 [accepted] PHST- 2024/11/01 00:22 [medline] PHST- 2024/09/15 14:09 [pubmed] PHST- 2024/09/14 18:04 [entrez] AID - S0944-5013(24)00296-9 [pii] AID - 10.1016/j.micres.2024.127895 [doi] PST - ppublish SO - Microbiol Res. 2024 Dec;289:127895. doi: 10.1016/j.micres.2024.127895. Epub 2024 Sep 7. PMID- 31438359 OWN - NLM STAT- MEDLINE DCOM- 20190904 LR - 20190904 IS - 1879-8365 (Electronic) IS - 0926-9630 (Linking) VI - 264 DP - 2019 Aug 21 TI - Development of In-Hospital Infection Management Using IoT. PG - 1817-1818 LID - 10.3233/SHTI190663 [doi] AB - As one of the countermeasures against infection at medical institutions, thorough hand hygiene is extremely important. In Japan, these controls are not sufficient. management, it is necessary to track the hand washing situation. Therefore, we decided to monitor the condition of hand washing by utilizing IoT. use IoT in our hospital, we decided to follow up using these environments. As a result, it is possible to collect data continuously for 24 hours, 365 days, and evaluate infection risk based on data. location information on smartphone, so we can also track work. We are considering support for medical staff by utilizing smart devices. FAU - Yamashita, Yoshinori AU - Yamashita Y AD - Department of Medical Informatics, University of Fukui, Fukui, Japan. FAU - Iwasaki, Hiromici AU - Iwasaki H AD - Center for Patient Safety and Infection Control, University of Fukui, Fukui, Japan. FAU - Muroi, Yoko AU - Muroi Y AD - Center for Patient Safety and Infection Control, University of Fukui, Fukui, Japan. FAU - Hida, Masao AU - Hida M AD - Department of Clinical Laboratory, University of Fukui, Fukui, Japan. FAU - Shigemi, Hiroko AU - Shigemi H AD - Center for Patient Safety and Infection Control, University of Fukui, Fukui, Japan. AD - Carecom co., ltd, Tokyo, Japan. LA - eng PT - Journal Article PL - Netherlands TA - Stud Health Technol Inform JT - Studies in health technology and informatics JID - 9214582 MH - *Cross Infection MH - Hand Disinfection MH - *Hand Hygiene MH - Humans MH - Japan OTO - NOTNLM OT - Hand Hygiene OT - Infection Control OT - Medical Staff EDAT- 2019/08/24 06:00 MHDA- 2019/09/05 06:00 CRDT- 2019/08/24 06:00 PHST- 2019/08/24 06:00 [entrez] PHST- 2019/08/24 06:00 [pubmed] PHST- 2019/09/05 06:00 [medline] AID - SHTI190663 [pii] AID - 10.3233/SHTI190663 [doi] PST - ppublish SO - Stud Health Technol Inform. 2019 Aug 21;264:1817-1818. doi: 10.3233/SHTI190663. PMID- 34540181 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220426 IS - 2008-3289 (Print) IS - 2008-4447 (Electronic) IS - 2008-3289 (Linking) VI - 13 IP - 3 DP - 2021 Jun TI - Soil yeast abundance and diversity assessment in a hot climatic region, semi-arid ecosystem. PG - 418-424 LID - 10.18502/ijm.v13i3.6406 [doi] AB - BACKGROUND AND OBJECTIVES: Yeasts are an important portion of microbial communities of soil due to their bioactivity for ecosystem safety. Soil yeast abundance and diversity are likely to be affected under harsh environmental and climatic conditions. In Iraq, human activity and climatic changes especially high temperature which may alter microbial communities in soil. Very little is known about yeast abundance and diversity in a hot climatic region. MATERIALS AND METHODS: By PCR technique, soil yeast abundance and diversity were investigated under extreme environmental and climatic conditions, as well as the effects of soil properties and vegetation cover in semi-arid lands. RESULTS: In all, 126 yeast strains were isolated and identified as belonging to 13 genera and 26 known species. The maximum quantity of yeast was 0.8 × 10(2) CFU g(-1) of soil, with significantly varied in abundance and diversity depending on soil properties and presence of vegetation. CONCLUSION: The results show that soil yeast abundance in these regions was significantly decreased. However, semi-arid lands are still rich in yeast diversity, and many species have adapted to survive in such conditions. CI - Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences. FAU - Al-Atrash, Mohammed Khalid AU - Al-Atrash MK AD - Department of Nursing, Baquba Technical Institute, Middle Technical University, Baghdad, Iraq. FAU - Khadur, Zwida K AU - Khadur ZK AD - Department of Nursing, Baquba Technical Institute, Middle Technical University, Baghdad, Iraq. FAU - Khadim, Anwar A AU - Khadim AA AD - Department of Nursing, Baquba Technical Institute, Middle Technical University, Baghdad, Iraq. LA - eng PT - Journal Article PL - Iran TA - Iran J Microbiol JT - Iranian journal of microbiology JID - 101518404 PMC - PMC8416586 OTO - NOTNLM OT - Microbial adaptation OT - Semi-arid lands OT - Soil yeasts OT - Yeasts diversity EDAT- 2021/09/21 06:00 MHDA- 2021/09/21 06:01 PMCR- 2021/06/01 CRDT- 2021/09/20 06:06 PHST- 2021/09/20 06:06 [entrez] PHST- 2021/09/21 06:00 [pubmed] PHST- 2021/09/21 06:01 [medline] PHST- 2021/06/01 00:00 [pmc-release] AID - IJM-13-418 [pii] AID - 10.18502/ijm.v13i3.6406 [doi] PST - ppublish SO - Iran J Microbiol. 2021 Jun;13(3):418-424. doi: 10.18502/ijm.v13i3.6406. PMID- 19353812 OWN - NLM STAT- MEDLINE DCOM- 20090616 LR - 20090407 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 47 IP - 5 DP - 2009 May TI - Climate change and food safety: an emerging issue with special focus on Europe. PG - 1009-21 LID - 10.1016/j.fct.2009.02.005 [doi] AB - According to general consensus, the global climate is changing, which may also affect agricultural and livestock production. The potential impact of climate change on food security is a widely debated and investigated issue. Nonetheless, the specific impact on safety of food and feed for consumers has remained a less studied topic. This review therefore identifies the various food safety issues that are likely to be affected by changes in climate, particularly in Europe. Amongst the issues identified are mycotoxins formed on plant products in the field or during storage; residues of pesticides in plant products affected by changes in pest pressure; trace elements and/or heavy metals in plant products depending on changes in their abundance and availability in soils; polycyclic aromatic hydrocarbons in foods following changes in long-range atmospheric transport and deposition into the environment; marine biotoxins in seafood following production of phycotoxins by harmful algal blooms; and the presence of pathogenic bacteria in foods following more frequent extreme weather conditions, such as flooding and heat waves. Research topics that are amenable to further research are highlighted. FAU - Miraglia, M AU - Miraglia M AD - National Center for Food Quality and Risk Assessment, Italian National Institute for Health (ISS), Viale Regina Elena 299, I-00166 Rome, Italy. marina.miraglia@iss.it FAU - Marvin, H J P AU - Marvin HJ FAU - Kleter, G A AU - Kleter GA FAU - Battilani, P AU - Battilani P FAU - Brera, C AU - Brera C FAU - Coni, E AU - Coni E FAU - Cubadda, F AU - Cubadda F FAU - Croci, L AU - Croci L FAU - De Santis, B AU - De Santis B FAU - Dekkers, S AU - Dekkers S FAU - Filippi, L AU - Filippi L FAU - Hutjes, R W A AU - Hutjes RW FAU - Noordam, M Y AU - Noordam MY FAU - Pisante, M AU - Pisante M FAU - Piva, G AU - Piva G FAU - Prandini, A AU - Prandini A FAU - Toti, L AU - Toti L FAU - van den Born, G J AU - van den Born GJ FAU - Vespermann, A AU - Vespermann A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 SB - IM MH - *Consumer Product Safety MH - Environmental Health MH - Europe MH - Food Contamination/*analysis MH - Food Microbiology MH - *Food Supply MH - *Greenhouse Effect MH - Humans RF - 96 EDAT- 2009/04/09 09:00 MHDA- 2009/06/17 09:00 CRDT- 2009/04/09 09:00 PHST- 2009/04/09 09:00 [entrez] PHST- 2009/04/09 09:00 [pubmed] PHST- 2009/06/17 09:00 [medline] AID - S0278-6915(09)00071-4 [pii] AID - 10.1016/j.fct.2009.02.005 [doi] PST - ppublish SO - Food Chem Toxicol. 2009 May;47(5):1009-21. doi: 10.1016/j.fct.2009.02.005. PMID- 10447544 OWN - NLM STAT- MEDLINE DCOM- 19991110 LR - 20190826 IS - 0342-4642 (Print) IS - 0342-4642 (Linking) VI - 25 IP - 8 DP - 1999 Aug TI - Exposure of the critically ill patient to extremely low-frequency electromagnetic fields in the intensive care environment. PG - 847-51 AB - OBJECTIVE: To measure the electromagnetic emission of intensive care medical equipment, in order to assess whether a potentially dangerous magnetic flux is present around the patient, and to evaluate the exposure conditions of the patient to extremely-low-frequency electromagnetic fields (ELF EMF). DESIGN: Descriptive study. SETTING: Intensive care unit (ICU) at a general hospital. MEASUREMENT AND RESULTS: The flux density of alternating (AC) 50-H2, EMF was measured and mapped around electrical devices in a six-beds adult ICU furnished with standard equipment (ventilator, monitor, infusion pumps, heated airbed, humidifier). The overall flux density in the patient area was assessed by measuring the field intensity at the patient's head during the day and at night over 6 days. The magnetic flux density was not uniformly distributed around each device, being higher [up to 40 microTesla (microT)] close to fan motors and mains supply. In 83 % of the patients a field intensity > 0.20 microT (safety limit) was detected. CONCLUSIONS: The ICU environment is at risk from electromagnetic pollution, the long-term stay of chronic patients and their "day-long" exposure are additional risk factors. EMFs drop off as the distance from the equipment is increased, according to the inverse-square law, and the exposure risk may be minimized by keeping a safety distance from the EMF source. The actual value of that safety distance may be variable and depends on several factors: (1) type of equipment, (2) orientation of equipment, (3) equipment "overcrowding" and (4) available space in each bed space. The magnetic flux density should be monitored regularly in every ICU for the specific design of each unit. FAU - Petrucci, N AU - Petrucci N AD - Department of Anaesthetics, Azienda Ospedaliera Desenzano, Loc. Montecroce, I-25 015 Desenzano D/G (BS), Italy. petrucci@gardanet.it LA - eng PT - Journal Article PL - United States TA - Intensive Care Med JT - Intensive care medicine JID - 7704851 SB - IM MH - Aged MH - *Critical Illness MH - Electromagnetic Fields/*adverse effects MH - Environmental Exposure/*adverse effects MH - Equipment Safety MH - Equipment and Supplies, Hospital/*adverse effects MH - Female MH - Humans MH - *Intensive Care Units MH - Male EDAT- 1999/08/14 00:00 MHDA- 1999/08/14 00:01 CRDT- 1999/08/14 00:00 PHST- 1999/08/14 00:00 [pubmed] PHST- 1999/08/14 00:01 [medline] PHST- 1999/08/14 00:00 [entrez] AID - 90250847.134 [pii] AID - 10.1007/s001340050963 [doi] PST - ppublish SO - Intensive Care Med. 1999 Aug;25(8):847-51. doi: 10.1007/s001340050963. PMID- 15046823 OWN - NLM STAT- MEDLINE DCOM- 20040517 LR - 20060313 IS - 0278-6915 (Print) IS - 0278-6915 (Linking) VI - 42 IP - 5 DP - 2004 May TI - Safety evaluation of phytosterol esters. Part 8. Lack of genotoxicity and subchronic toxicity with phytosterol oxides. PG - 771-83 AB - Vegetable oil spreads containing phytosterol-esters are marketed as a cholesterol-lowering functional food in more than 20 countries worldwide. An extensive package of safety data has shown phytosterol-esters to be safe for human use. However, even though phytosterols are very stable molecules, oxidation may occur at low levels under extreme heating conditions, resulting in phytosterol oxides. As there is some suggestion of adverse biological effects in the literature for the related cholesterol oxidation products, safety data have been generated for phytosterol oxides. A phytosterol oxide concentrate (POC) was generated by prolonged heating of phytosterol-esters in the presence of oxygen. The genotoxicity and subchronic toxicity of this mixture was assessed in a series of in vitro genotoxicity assays (bacterial mutation, chromosome aberration and micronucleus) and a subchronic feeding study in the rat. Results showed that a phytosterol oxide concentrate containing approximately 30% phytosterol oxides did not possess genotoxic potential and no obvious evidence of toxicity when administered in the diet of the rat for 90 consecutive days. In the latter study, a NOEL was established at an estimated dietary level of phytosterol oxides of 128 mg/kg/day for males and 144 mg/kg/day for females. In conclusion, these materials have been shown to raise no obvious concerns for human safety. FAU - Lea, L J AU - Lea LJ AD - Safety & Environmental Assurance Centre, Unilever Colworth, Sharnbrook, Bedford MK44 1LQ, UK. linda.lea@unilever.com FAU - Hepburn, P A AU - Hepburn PA FAU - Wolfreys, A M AU - Wolfreys AM FAU - Baldrick, P AU - Baldrick P LA - eng PT - Journal Article PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 0 (Esters) RN - 0 (Oxides) RN - 0 (Phytosterols) SB - IM MH - Administration, Oral MH - Animals MH - Body Weight/drug effects MH - Chromosome Aberrations/*chemically induced MH - Consumer Product Safety MH - Dose-Response Relationship, Drug MH - Eating/drug effects MH - Esters MH - Female MH - Male MH - Micronucleus Tests MH - Mutagenicity Tests MH - No-Observed-Adverse-Effect Level MH - Oxidation-Reduction MH - Oxides/*toxicity MH - Phytosterols/*toxicity MH - Random Allocation MH - Rats MH - Rats, Wistar MH - Risk Assessment MH - Salmonella typhimurium/drug effects MH - Toxicity Tests EDAT- 2004/03/30 05:00 MHDA- 2004/05/18 05:00 CRDT- 2004/03/30 05:00 PHST- 2003/03/20 00:00 [received] PHST- 2003/12/24 00:00 [accepted] PHST- 2004/03/30 05:00 [pubmed] PHST- 2004/05/18 05:00 [medline] PHST- 2004/03/30 05:00 [entrez] AID - S0278691504000031 [pii] AID - 10.1016/j.fct.2003.12.014 [doi] PST - ppublish SO - Food Chem Toxicol. 2004 May;42(5):771-83. doi: 10.1016/j.fct.2003.12.014. PMID- 37979386 OWN - NLM STAT- MEDLINE DCOM- 20231130 LR - 20231130 IS - 1095-8630 (Electronic) IS - 0301-4797 (Linking) VI - 349 DP - 2024 Jan 1 TI - Heat exposure assessment based on high-resolution spatio-temporal data of population dynamics and temperature variations. PG - 119576 LID - S0301-4797(23)02364-2 [pii] LID - 10.1016/j.jenvman.2023.119576 [doi] AB - Urban heat waves pose a significant risk to the health and safety of city dwellers, with urbanization potentially amplifying the health impact of extreme heat. Accurate assessments of population heat exposure hinge on the interplay between temperature, population spatial dynamics, and the epidemiological effects of temperature on health. Yet, many past studies have over-simplified the matter by assuming static populations, leading to substantial inaccuracies in heat exposure assessments. To address these issues, this study integrates dynamic population data, fluctuating temperature, and the exposure-response relationship between temperature and health to construct an advanced heat exposure assessment framework predicated on a population dynamic model. We analyzed urban heat island characteristics, population dynamics, and heat exposure during heat wave conditions in Beijing, a major city in China. Our findings highlight significant intra-day population movement between urban and suburban areas during heat wave conditions, with spatial population flow patterns showing clear scale-dependent characteristics. These population flow dynamics intensify heat exposure levels, and the disparity between dynamic population-weighted temperature and average temperature is most pronounced at night. Our research provides a more comprehensive understanding of real urban population heat exposure levels and can furnish city administrators with more scientifically rigorous evidence. CI - Copyright © 2023 Elsevier Ltd. All rights reserved. FAU - Sun, Zhaobin AU - Sun Z AD - State Key Laboratory of Severe Weather (LASW), Chinese Academy of Meteorological Sciences (CAMS), China Meteorological Administration, Beijing, 100081, China. Electronic address: szb850804@163.com. FAU - Zhang, Xiaoling AU - Zhang X AD - Beijing Meteorological Data Center, Beijing, 100097, China. FAU - Li, Ziming AU - Li Z AD - Beijing Meteorological Observatory, Beijing, 100089, China. FAU - Liang, Yinglin AU - Liang Y AD - State Key Laboratory of Severe Weather (LASW), Chinese Academy of Meteorological Sciences (CAMS), China Meteorological Administration, Beijing, 100081, China. FAU - An, Xingqin AU - An X AD - State Key Laboratory of Severe Weather (LASW), Chinese Academy of Meteorological Sciences (CAMS), China Meteorological Administration, Beijing, 100081, China; Institute of Urban Meteorology, China Meteorological Administration, Beijing, 100089, China. FAU - Zhao, Yuxin AU - Zhao Y AD - State Key Laboratory of Severe Weather (LASW), Chinese Academy of Meteorological Sciences (CAMS), China Meteorological Administration, Beijing, 100081, China. FAU - Miao, Shiguang AU - Miao S AD - Institute of Urban Meteorology, China Meteorological Administration, Beijing, 100089, China; Key Laboratory of Urban Meteorology, China Meteorological Administration, Beijing, 100089, China. FAU - Han, Ling AU - Han L AD - State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. FAU - Li, Demin AU - Li D AD - National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, 100192, China. LA - eng PT - Journal Article DEP - 20231117 PL - England TA - J Environ Manage JT - Journal of environmental management JID - 0401664 SB - IM MH - Temperature MH - Cities MH - *Hot Temperature MH - *Urbanization MH - Population Dynamics OTO - NOTNLM OT - Dynamic population OT - Exposure risk OT - Heat wave OT - Urbanization COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/11/19 09:42 MHDA- 2023/11/30 06:42 CRDT- 2023/11/18 18:08 PHST- 2023/06/17 00:00 [received] PHST- 2023/11/04 00:00 [revised] PHST- 2023/11/06 00:00 [accepted] PHST- 2023/11/30 06:42 [medline] PHST- 2023/11/19 09:42 [pubmed] PHST- 2023/11/18 18:08 [entrez] AID - S0301-4797(23)02364-2 [pii] AID - 10.1016/j.jenvman.2023.119576 [doi] PST - ppublish SO - J Environ Manage. 2024 Jan 1;349:119576. doi: 10.1016/j.jenvman.2023.119576. Epub 2023 Nov 17. PMID- 32344242 OWN - NLM STAT- MEDLINE DCOM- 20200525 LR - 20221207 IS - 1873-2976 (Electronic) IS - 0960-8524 (Linking) VI - 310 DP - 2020 Aug TI - Nitrogen removal bacterial strains, MSNA-1 and MSD4, with wide ranges of salinity and pH resistances. PG - 123309 LID - S0960-8524(20)30581-2 [pii] LID - 10.1016/j.biortech.2020.123309 [doi] AB - Nitrogenous wastewater is difficult to treat using conventional microorganisms in high salinity and acidic/alkaline environments. Two halotolerant bacteria, heterotrophic nitrifying Stenotrophomonas sp. MSNA-1 and aerobic denitrifying Pseudomonas sp. MSD4, were isolated, and the amplification of functional genes provided the evidences of nitrogen removal performance. The results regarding salinity and pH resistance showed that strain MSNA-1 is robust at salinities of 0-15% and pH of 3-10. It can remove 51.2% of NH(4)(+)-N (180 mg/L) at salinity of 10% (pH: 7) and 49.2% of NH(4)(+)-N under pH 4 (salinity: 3%). For strain MSD4, it is robust at salinities of 0-10% and pH of 5-11. It can remove 62.4% of TN (100 mg/L) at salinity of 7% (pH: 7) and 72.2% of TN under pH 9 (salinity: 3%). Their excellent salinity and pH resistances make them promising candidates for treating nitrogenous wastewaters under extreme conditions with low operational cost. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Zeng, Xiaoying AU - Zeng X AD - College of Environmental Science and Engineering/Sino-Canada Joint R&D Centre for Water and Environmental Safety, Nankai University, Tianjin 300071, PR China. FAU - Huang, Jinhui Jeanne AU - Huang JJ AD - College of Environmental Science and Engineering/Sino-Canada Joint R&D Centre for Water and Environmental Safety, Nankai University, Tianjin 300071, PR China. Electronic address: huangj@nankai.edu.cn. FAU - Hua, Binbin AU - Hua B AD - College of Environmental Science and Engineering/Sino-Canada Joint R&D Centre for Water and Environmental Safety, Nankai University, Tianjin 300071, PR China. FAU - Champagne, Pascale AU - Champagne P AD - College of Environmental Science and Engineering/Sino-Canada Joint R&D Centre for Water and Environmental Safety, Nankai University, Tianjin 300071, PR China; Department of Civil Engineering, Queen's University, Kinston, Ontario K7L 3N6, Canada. LA - eng PT - Journal Article DEP - 20200406 PL - England TA - Bioresour Technol JT - Bioresource technology JID - 9889523 RN - 0 (Nitrites) RN - 0 (Waste Water) RN - N762921K75 (Nitrogen) SB - IM MH - Aerobiosis MH - *Denitrification MH - Heterotrophic Processes MH - Hydrogen-Ion Concentration MH - Nitrification MH - Nitrites MH - *Nitrogen MH - Salinity MH - Wastewater OTO - NOTNLM OT - Aerobic denitrification OT - Extreme pH resistance OT - Functional genes amplification OT - Heterotrophic nitrification OT - High salinity resistance COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/04/29 06:00 MHDA- 2020/05/26 06:00 CRDT- 2020/04/29 06:00 PHST- 2020/02/13 00:00 [received] PHST- 2020/03/31 00:00 [revised] PHST- 2020/04/01 00:00 [accepted] PHST- 2020/04/29 06:00 [pubmed] PHST- 2020/05/26 06:00 [medline] PHST- 2020/04/29 06:00 [entrez] AID - S0960-8524(20)30581-2 [pii] AID - 10.1016/j.biortech.2020.123309 [doi] PST - ppublish SO - Bioresour Technol. 2020 Aug;310:123309. doi: 10.1016/j.biortech.2020.123309. Epub 2020 Apr 6. PMID- 18409664 OWN - NLM STAT- MEDLINE DCOM- 20080725 LR - 20080415 IS - 1592-7830 (Print) IS - 1592-7830 (Linking) VI - 29 IP - 3 Suppl DP - 2007 Jul-Sep TI - [Health management of Saipem workers with projects involving abroad activities]. PG - 237-9 AB - In remote areas and in developing countries, where adequate health-care structures are few and sparse, Occupational Medicine contributes to guaranteeing workers' health. Companies like Saipem, involved in activities that are carried out in remote, inhospitable areas must ensure the safety and guarantee the health conditions of workers in relation to the risk factors connected with the job as well as with the environment in which it is performed. In such situations, Occupational Medicine addresses both the health aspects of the workplace and of the community, and is the pivot around which revolves the health-care support of workers employed abroad in the sense of protection and enhancement of health. The risks connected with work abroad are of three main types: 1) job-related risks; 2) risks connected with the environment; 3) risks related to the organization of work and the changes in the worker's daily life. The job-related risks are similar to those connected with analogous jobs performed elsewhere. The risks connected with the environment are related to adverse climatic conditions, extreme temperatures and unknown and often dangerous flora and fauna. The occupational physician is called upon to assess the suitability of workers for jobs that are based in remote areas. The main clinical conditions that can prevent issue of the Medical Fitness Certificate to workers for long-stay jobs abroad are discussed. FAU - Nicosia, V AU - Nicosia V AD - QHSE SAIPEM/ Medical Dept. Saipem spa, Via Martiri di Cefalonia 67, 20097 San Donato Milanese. FAU - De Sanctis, S AU - De Sanctis S FAU - Mika, F AU - Mika F FAU - Consentino, M AU - Consentino M FAU - Mascheroni, G AU - Mascheroni G LA - ita PT - English Abstract PT - Journal Article TT - Gestione della salute dei dipendenti Saipem S.p.A. assegnati ai progetti lavorativi all'estero. PL - Italy TA - G Ital Med Lav Ergon JT - Giornale italiano di medicina del lavoro ed ergonomia JID - 9712708 SB - IM MH - *Extraction and Processing Industry MH - Humans MH - Internationality MH - Italy MH - *Occupational Health EDAT- 2008/04/16 09:00 MHDA- 2008/07/26 09:00 CRDT- 2008/04/16 09:00 PHST- 2008/04/16 09:00 [pubmed] PHST- 2008/07/26 09:00 [medline] PHST- 2008/04/16 09:00 [entrez] PST - ppublish SO - G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):237-9. PMID- 38847752 OWN - NLM STAT- MEDLINE DCOM- 20240703 LR - 20240703 IS - 1750-3841 (Electronic) IS - 0022-1147 (Linking) VI - 89 IP - 7 DP - 2024 Jul TI - Review on emerging applications of nanobiosensor in food safety. PG - 3950-3972 LID - 10.1111/1750-3841.17149 [doi] AB - Nanosensors have become an indispensable tool in the food sector due to their specificity and sensitivity. The biosensor consists of a transducer coupled with a biorecognition component to transform biological signal into digital signal. Nanobiosensors have been widely used for sensing toxic chemicals such as pesticide residues and pathogenic microbes owing to their accurate sensitivity in an affordable manner, which gives more hope to the food industry on their applications. It employs nanocarriers to bind to impurities and pollutants, as well as food-borne microorganisms and their resulting toxins, such as mycotoxins. This modern technology ensures food safety in food processing industries. Nowadays, nanoparticle-immobilized sensors act as spot indicators to improve smart food packing technology. Certain types of nanobiosensors are deployed to monitor food product manufacture till packaging and to check the freshness of the product till spoilage identification. They are mainly using enzyme catalysts, which are highly sensitive to extreme environmental conditions. As a result, there is a greater evaluation requirement in nanosensor technology to adopt any temperature, pH, or other difficult parameters. Its stability, while in contact with food substrates, is another criterion that needs to be regularized. Within this framework, this review delves into the latest developments in nanobiosensors and the obstacles encountered during their use across different food industries. CI - © 2024 Institute of Food Technologists. FAU - Guruprasath, N AU - Guruprasath N AD - Department of Food Technology, Hindustan Institute of Technology and Science, Chennai, Tamil Nadu, India. FAU - Sankarganesh, P AU - Sankarganesh P AUID- ORCID: 0000-0003-3737-9184 AD - Department of Food Technology, Hindustan Institute of Technology and Science, Chennai, Tamil Nadu, India. FAU - Adeyeye, S A O AU - Adeyeye SAO AD - Department of Food Technology, Hindustan Institute of Technology and Science, Chennai, Tamil Nadu, India. FAU - Babu, A Surendra AU - Babu AS AD - Department of Food Science and Technology, School of Agricultural Sciences, Malla Reddy University, Hyderabad, India. FAU - Parthasarathy, V AU - Parthasarathy V AD - Department of Physics, Rajalakshmi Institute of Technology, Chennai, India. LA - eng PT - Journal Article PT - Review DEP - 20240607 PL - United States TA - J Food Sci JT - Journal of food science JID - 0014052 SB - IM MH - *Biosensing Techniques/methods/instrumentation MH - *Food Safety/methods MH - *Food Contamination/analysis MH - Nanotechnology/methods MH - Food Microbiology/methods MH - Nanoparticles OTO - NOTNLM OT - food adulterants OT - food pathogen OT - food pesticides OT - nanobiosensor OT - nanoparticles OT - nanosensor EDAT- 2024/06/07 12:58 MHDA- 2024/07/03 06:42 CRDT- 2024/06/07 10:23 PHST- 2024/04/27 00:00 [revised] PHST- 2024/01/20 00:00 [received] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/07/03 06:42 [medline] PHST- 2024/06/07 12:58 [pubmed] PHST- 2024/06/07 10:23 [entrez] AID - 10.1111/1750-3841.17149 [doi] PST - ppublish SO - J Food Sci. 2024 Jul;89(7):3950-3972. doi: 10.1111/1750-3841.17149. Epub 2024 Jun 7. PMID- 26164282 OWN - NLM STAT- MEDLINE DCOM- 20160518 LR - 20150822 IS - 1879-1700 (Electronic) IS - 0265-931X (Linking) VI - 148 DP - 2015 Oct TI - Dynamic evaluation of environmental impact due to tritium accidental release from the fusion reactor. PG - 137-40 LID - S0265-931X(15)30026-6 [pii] LID - 10.1016/j.jenvrad.2015.06.013 [doi] AB - As one of the key safety issues of fusion reactors, tritium environmental impact of fusion accidents has attracted great attention. In this work, the dynamic tritium concentrations in the air and human body were evaluated on the time scale based on accidental release scenarios under the extreme environmental conditions. The radiation dose through various exposure pathways was assessed to find out the potential relationships among them. Based on this work, the limits of HT and HTO release amount for arbitrary accidents were proposed for the fusion reactor according to dose limit of ITER. The dynamic results aim to give practical guidance for establishment of fusion emergency standard and design of fusion tritium system. CI - Copyright © 2015 Elsevier Ltd. All rights reserved. FAU - Nie, Baojie AU - Nie B AD - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031, China; University of Science and Technology of China, Hefei, Anhui 230027, China. FAU - Ni, Muyi AU - Ni M AD - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031, China. Electronic address: muyi.ni@fds.org.cn. FAU - Jiang, Jieqiong AU - Jiang J AD - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031, China. FAU - Wu, Yican AU - Wu Y AD - Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei, Anhui 230031, China; University of Science and Technology of China, Hefei, Anhui 230027, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150708 PL - England TA - J Environ Radioact JT - Journal of environmental radioactivity JID - 8508119 RN - 0 (Air Pollutants, Radioactive) RN - 10028-17-8 (Tritium) SB - IM MH - Air Pollutants, Radioactive/analysis/*metabolism MH - Humans MH - Models, Theoretical MH - *Nuclear Reactors MH - *Radiation Dosage MH - *Radiation Exposure MH - Radiation Monitoring MH - Tritium/analysis/*metabolism OTO - NOTNLM OT - Accidental release OT - Fusion reactor OT - Public dose OT - Tritium release amount EDAT- 2015/07/15 06:00 MHDA- 2016/05/19 06:00 CRDT- 2015/07/13 06:00 PHST- 2015/04/16 00:00 [received] PHST- 2015/06/16 00:00 [revised] PHST- 2015/06/18 00:00 [accepted] PHST- 2015/07/13 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2016/05/19 06:00 [medline] AID - S0265-931X(15)30026-6 [pii] AID - 10.1016/j.jenvrad.2015.06.013 [doi] PST - ppublish SO - J Environ Radioact. 2015 Oct;148:137-40. doi: 10.1016/j.jenvrad.2015.06.013. Epub 2015 Jul 8. PMID- 38659580 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240426 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 15 DP - 2024 TI - Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy. PG - 1379236 LID - 10.3389/fphar.2024.1379236 [doi] LID - 1379236 AB - Introduction: Hypertrophic cardiomyopathy (HCM) is a leading cause of lethal arrhythmias in the young. Although the arrhythmic substrate has been hypothesised to be amenable to late Na(+) block with ranolazine, the specific mechanisms are not fully understood. Therefore, this study aimed to investigate the substrate mechanisms of safety and antiarrhythmic efficacy of ranolazine in HCM. Methods: Computational models of human tissue and ventricles were used to simulate the electrophysiological behaviour of diseased HCM myocardium for variable degrees of repolarisation impairment, validated against in vitro and clinical recordings. S1-S2 pacing protocols were used to quantify arrhythmic risk in scenarios of (i) untreated HCM-remodelled myocardium and (ii) myocardium treated with 3µM, 6µM and 10µM ranolazine, for variable repolarisation heterogeneity sizes and pacing rates. ECGs were derived from biventricular simulations to identify ECG biomarkers linked to antiarrhythmic effects. Results: 10µM ranolazine given to models manifesting ventricular tachycardia (VT) at baseline led to a 40% reduction in number of VT episodes on pooled analysis of >40,000 re-entry inducibility simulations. Antiarrhythmic efficacy and safety were dependent on the degree of repolarisation impairment, with optimal benefit in models with maximum JT(c) interval <370 ms. Ranolazine increased risk of VT only in models with severe-extreme repolarisation impairment. Conclusion: Ranolazine efficacy and safety may be critically dependent upon the degree of repolarisation impairment in HCM. For moderate repolarisation impairment, reductions in refractoriness heterogeneity by ranolazine may prevent conduction blocks and re-entry. With severe-extreme disease substrates, reductions of the refractory period can increase re-entry sustainability. CI - Copyright © 2024 Coleman, Doste, Beltrami, Argirò, Coppini, Olivotto, Raman and Bueno-Orovio. FAU - Coleman, James A AU - Coleman JA AD - Department of Computer Science, University of Oxford, Oxford, United Kingdom. FAU - Doste, Ruben AU - Doste R AD - Department of Computer Science, University of Oxford, Oxford, United Kingdom. FAU - Beltrami, Matteo AU - Beltrami M AD - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy. FAU - Argirò, Alessia AU - Argirò A AD - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy. FAU - Coppini, Raffaele AU - Coppini R AD - Department of NeuroFarBa, University of Florence, Florence, Italy. FAU - Olivotto, Iacopo AU - Olivotto I AD - Cardiomyopathy Unit, Careggi University Hospital, Florence, Italy. AD - Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Raman, Betty AU - Raman B AD - Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom. FAU - Bueno-Orovio, Alfonso AU - Bueno-Orovio A AD - Department of Computer Science, University of Oxford, Oxford, United Kingdom. LA - eng PT - Journal Article DEP - 20240410 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC11039821 OTO - NOTNLM OT - arrhythmic risk OT - drug safety and efficacy OT - hypertrophic cardiomyopathy OT - modelling and simulation OT - ranolazine COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/04/25 06:49 MHDA- 2024/04/25 06:50 PMCR- 2024/04/10 CRDT- 2024/04/25 03:48 PHST- 2024/01/30 00:00 [received] PHST- 2024/03/25 00:00 [accepted] PHST- 2024/04/25 06:50 [medline] PHST- 2024/04/25 06:49 [pubmed] PHST- 2024/04/25 03:48 [entrez] PHST- 2024/04/10 00:00 [pmc-release] AID - 1379236 [pii] AID - 10.3389/fphar.2024.1379236 [doi] PST - epublish SO - Front Pharmacol. 2024 Apr 10;15:1379236. doi: 10.3389/fphar.2024.1379236. eCollection 2024. PMID- 31475663 OWN - NLM STAT- MEDLINE DCOM- 20200309 LR - 20200309 IS - 1945-1938 (Electronic) IS - 1049-023X (Linking) VI - 34 IP - 5 DP - 2019 Oct TI - Analysis of the Potential of IT System Support in Early Warning Systems: Mitigating Flood Risk in Poland. PG - 563-565 LID - 10.1017/S1049023X19004801 [doi] AB - Nowadays, extreme weather and atmospheric conditions are becoming more frequent and more intense. It seems obvious that together with climate change, the vulnerability of the public and of individual regions to the risks of various types of natural hazards also increases. This would increase the importance of organization concerning potential measures to protect against these extraordinary events, and to prepare for reducing their ramifications.One such initiative is the creation of an early warning system for inhabitants of a given area of a country, to help guard against the extraordinary threat associated with a natural disaster; especially floods. The creation of such a system is aimed at increasing public safety and limiting losses caused by the occurrence of natural, technological, and synergistic hazards. Particular emphasis during the construction of a current system is placed on supporting flood risk management, which is aimed at increasing the safety of citizens and reducing losses caused by the occurrence of flooding in Poland. This would be possible by the identification of areas threatened by flooding throughout the country, and then limiting economic expansion in these areas.Ultimately, the project aims to consolidate information regarding hazardous events and gather them in a professional Information Technology (IT) system, using an integrated database and a modern module for disseminating information to end users. The system is to provide access to this information for both the administration and the individual citizen.This article presents the potential of a so called "IT System for the Country's Protection Against Extreme Hazards," which is currently being developed in Poland, with particular emphasis on reducing the risks related to natural disasters and minimizing the problems of crisis management in Poland. This article is also aimed at opening discussions and creating a basis for the exchange of information from countries implementing similar solutions, especially neighboring countries, with which joint action could be undertaken. FAU - Goniewicz, Krzysztof AU - Goniewicz K AUID- ORCID: 0000-0003-4368-6850 AD - Department of Security Studies, Polish Air Force Academy, Deblin, Poland. FAU - Burkle, Frederick M AU - Burkle FM AUID- ORCID: 0000-0002-5110-7284 AD - Harvard Humanitarian Initiative, T.H. Chan School of Public Health, Harvard University, Cambridge, MassachusettsUSA. LA - eng PT - Journal Article DEP - 20190902 PL - United States TA - Prehosp Disaster Med JT - Prehospital and disaster medicine JID - 8918173 MH - *Disaster Planning MH - *Floods MH - Humans MH - *Information Technology MH - Poland MH - Risk Assessment MH - Risk Management OTO - NOTNLM OT - disasters OT - early warning systems OT - flood OT - hazards EDAT- 2019/09/03 06:00 MHDA- 2020/03/10 06:00 CRDT- 2019/09/03 06:00 PHST- 2019/09/03 06:00 [pubmed] PHST- 2020/03/10 06:00 [medline] PHST- 2019/09/03 06:00 [entrez] AID - S1049023X19004801 [pii] AID - 10.1017/S1049023X19004801 [doi] PST - ppublish SO - Prehosp Disaster Med. 2019 Oct;34(5):563-565. doi: 10.1017/S1049023X19004801. Epub 2019 Sep 2. PMID- 37259738 OWN - NLM STAT- MEDLINE DCOM- 20230602 LR - 20230820 IS - 2284-0729 (Electronic) IS - 1128-3602 (Linking) VI - 27 IP - 10 DP - 2023 May TI - Salvage camrelizumab for an intractable NK/T cell lymphoma patient with two instances of intestinal perforation: a case report and literature review. PG - 4570-4577 LID - 32463 [pii] LID - 10.26355/eurrev_202305_32463 [doi] AB - BACKGROUND: The prognosis of natural killer/T cell lymphoma (NKTCL) with multifocal small intestine involvement complicated by intestinal perforation is extremely poor. There is no evidence-based treatment strategy for this intractable condition. CASE PRESENTATION: A 30-year-old male was admitted to our hospital in April 2017 and presented with recurrent fever for three months and multiple painless subcutaneous nodules in the abdominal wall. An excision biopsy of the subcutaneous nodules in the abdominal wall revealed NKTCL. The patient was diagnosed with stage IVB NKTCL with skin and multifocal small intestinal involvement according to the imaging results. The first intestinal perforation occurred due to tumor infiltration before the initial treatment. The second intestinal perforation occurred after receiving two cycles of chemotherapy with a modified SMILE regimen. The histone deacetylase inhibitor (HDACi) chidamide was administered as a single-agent therapy after recovery from the second intestinal perforation. Complete remission was achieved. Unfortunately, five months later, the patient was confirmed to have relapsed and received the salvage chemotherapy. The patient suffered from disease progression again after the fourth cycle of chemotherapy. At this point, from May 29, 2018, the patient started to receive injections of the anti-programmed death 1 (PD-1) antibody camrelizumab as a salvage treatment. Two months after the initial anti-PD-1 antibody camrelizumab injection, the response was partial remission. Disease progression was confirmed in March 2021, with a progression-free survival time of 34 months. CONCLUSIONS: NKTCL patients with multifocal small intestine involvement have a high risk of intestinal perforation. The possible etiologies of bowel perforation include tumor infiltration, tumor necrosis in response to therapy, and acute inflammation. The anti-PD-1 antibody camrelizumab may be a new candidate agent for treating this type of intractable NKTCL. Further observations are necessary to identify the efficacy and safety of new agents in the future. FAU - Xia, Y AU - Xia Y AD - Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. lily-1228@hotmail.com. FAU - Li, Q-H AU - Li QH FAU - Liu, T AU - Liu T FAU - Liu, X-X AU - Liu XX FAU - Pan, H-X AU - Pan HX FAU - Zhang, L-L AU - Zhang LL FAU - Zhu, F AU - Zhu F LA - eng PT - Case Reports PT - Journal Article PT - Review PL - Italy TA - Eur Rev Med Pharmacol Sci JT - European review for medical and pharmacological sciences JID - 9717360 RN - 73096E137E (camrelizumab) SB - IM MH - Male MH - Humans MH - Adult MH - *Intestinal Perforation/drug therapy MH - *Lymphoma MH - Disease Progression MH - *Lymphoma, T-Cell MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use EDAT- 2023/06/01 06:42 MHDA- 2023/06/02 06:42 CRDT- 2023/06/01 04:09 PHST- 2023/06/02 06:42 [medline] PHST- 2023/06/01 06:42 [pubmed] PHST- 2023/06/01 04:09 [entrez] AID - 32463 [pii] AID - 10.26355/eurrev_202305_32463 [doi] PST - ppublish SO - Eur Rev Med Pharmacol Sci. 2023 May;27(10):4570-4577. doi: 10.26355/eurrev_202305_32463. PMID- 30285491 OWN - NLM STAT- MEDLINE DCOM- 20190506 LR - 20190506 IS - 1545-4487 (Electronic) IS - 0066-4170 (Linking) VI - 64 DP - 2019 Jan 7 TI - Biology and Control of the Khapra Beetle, Trogoderma granarium, a Major Quarantine Threat to Global Food Security. PG - 131-148 LID - 10.1146/annurev-ento-011118-111804 [doi] AB - The khapra beetle, Trogoderma granarium, is a voracious feeder of stored products and is considered one of the most important quarantine pests globally. Its ability to survive for long periods under extreme conditions facilitates its spread through international commerce, which has led to invasions of new geographic regions. The khapra beetle is an important quarantine pest for many countries, including the major wheat-producing countries the United States, Canada, Russia, and Australia, and has been classified as one of the 100 worst invasive species worldwide. This species cannot always be controlled by insecticides and other nonchemical methods that are usually effective against other pests of stored products, particularly owing to its diapausing late larval stage. It can rapidly develop at elevated temperatures and under dry conditions, which are not favorable for many major stored-product insects. We synthesize key published work to draw attention to advances in biology, detection and control of the khapra beetle, and directions to consider for future research. FAU - Athanassiou, Christos G AU - Athanassiou CG AD - Laboratory of Entomology and Agricultural Zoology, Department of Agriculture Crop Production and Rural Environment, University of Thessaly, Nea Ionia, Magnesia 384 46, Greece; email: athanassiou@uth.gr. FAU - Phillips, Thomas W AU - Phillips TW AD - Department of Entomology, Kansas State University, Manhattan, Kansas 66506-4004, USA; email: twp1@ksu.edu. FAU - Wakil, Waqas AU - Wakil W AD - Department of Entomology, University of Agriculture, Faisalabad 38040, Pakistan; email: waqaswakeel@hotmail.com. LA - eng PT - Journal Article PT - Review DEP - 20181004 PL - United States TA - Annu Rev Entomol JT - Annual review of entomology JID - 0372367 SB - IM MH - Animals MH - *Coleoptera MH - Edible Grain/*parasitology MH - Food Supply MH - *Insect Control MH - *Introduced Species OTO - NOTNLM OT - Coleoptera OT - Dermestidae OT - food safety OT - invasive species OT - quarantine pest OT - stored products EDAT- 2018/10/05 06:00 MHDA- 2019/05/07 06:00 CRDT- 2018/10/05 06:00 PHST- 2018/10/05 06:00 [pubmed] PHST- 2019/05/07 06:00 [medline] PHST- 2018/10/05 06:00 [entrez] AID - 10.1146/annurev-ento-011118-111804 [doi] PST - ppublish SO - Annu Rev Entomol. 2019 Jan 7;64:131-148. doi: 10.1146/annurev-ento-011118-111804. Epub 2018 Oct 4. PMID- 11692973 OWN - NLM STAT- MEDLINE DCOM- 20011207 LR - 20170214 IS - 0706-7437 (Print) IS - 0706-7437 (Linking) VI - 46 IP - 8 DP - 2001 Oct TI - The use of electroconvulsive therapy in special patient populations. PG - 710-9 AB - BACKGROUND: Despite its well-established efficacy and its increasing use, electroconvulsive therapy (ECT) remains a controversial treatment. Lack of clarity in the issues related to its use in special patient populations (for example, in children, in adolescents, in pregnant women, in the elderly, and in the medically ill) often contributes to the debate about the use of ECT. METHOD: The literature on ECT use in special patient populations is reviewed, together with the commonly associated high-risk medical conditions in clinical practice. Specific reference is made in each case to the safety, tolerability, and efficacy of the procedure. RESULTS: Much of the literature surveyed consists of case studies, although a few controlled trials are available. In general, ECT use in special populations is relatively safe and extremely effective. In small case series, ECT use in children and adolescents is effective but requires further systematic study. In pregnant women, ECT is very effective, and with proper medical care, it is relatively safe in all trimesters of pregnancy, as well as in the postpartum period. The frail elderly are particularly good candidates for ECT because they are often unresponsive to or intolerant of psychotropic medication. Medical conditions that should receive particular attention during a course of ECT are disorders of the central nervous system (CNS), cardiovascular, and respiratory system. With modern anesthesia techniques and careful medical management of each high-risk patient, most can successfully complete a course of ECT. The process of obtaining informed consent also requires special consideration in this group of patients because their capacity to consent to treatment may be compromised. CONCLUSIONS: With careful attention to each patient's medical and anesthesia needs, ECT is an effective and relatively safe procedure in high-risk special patient populations. FAU - Rabheru, K AU - Rabheru K AD - Department of Psychiatry, University of Western Ontario, London, Ontario. LA - eng PT - Journal Article PT - Review PL - United States TA - Can J Psychiatry JT - Canadian journal of psychiatry. Revue canadienne de psychiatrie JID - 7904187 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Brain Neoplasms/*psychology MH - Cardiovascular Diseases/*psychology MH - Child MH - Chronic Disease/psychology MH - Depression, Postpartum/*therapy MH - Depressive Disorder/*etiology/therapy MH - Electroconvulsive Therapy/*methods MH - Female MH - Humans MH - Informed Consent MH - Male MH - Pregnancy MH - Pregnancy Complications MH - Treatment Outcome RF - 169 EDAT- 2001/11/06 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/11/06 10:00 PHST- 2001/11/06 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/11/06 10:00 [entrez] AID - 10.1177/070674370104600803 [doi] PST - ppublish SO - Can J Psychiatry. 2001 Oct;46(8):710-9. doi: 10.1177/070674370104600803. PMID- 36563070 OWN - NLM STAT- MEDLINE DCOM- 20221227 LR - 20221230 IS - 1724-5990 (Electronic) IS - 0393-5590 (Linking) VI - 39 IP - 5 DP - 2022 Oct 31 TI - [Finerenone for the treatment of patients with chronic kidney disease]. LID - 2022-vol5 [pii] AB - Chronic kidney disease (CKD) is a clinical condition associated with a high risk of cardiovascular (CV) events, mortality and progression to most severe stage of the disease, also known as kidney failure (KF). CKD is characterized by a wide variability of progression, which depends, in part, on the variability of individual response to nephroprotective treatments. Thus, a consistent proportion of patients have an elevated residual risk both CV and renal events, confirmed by the evidence that about 70% of CKD patients followed by the nephrologist have residual proteinuria. Among the new therapeutic strategies, which have been developed precisely with the aim of minimizing this residual risk, a class of particular interest is represented by the new non-steroidal mineralocorticoid receptor antagonists (non-steroidal MRA). These drugs exert an important anti-fibrotic and anti-proteinuric effect and, unlike steroid MRAs, are associated with a much lower incidence of adverse effects. The non-steroidal MRA molecule for which the most data is available, which is finerenone, is potent and extremely selective, and this partly explains the differences in efficacy and safety compared to steroid MRAs. In clinical trials, finerenone has been shown to significantly reduce the risk of progression to KF. Furthermore, there is also evidence that the combination of non-steroidal MRAs together with SGLT2 inhibitors may represent a valid alternative to reduce the residual risk in CKD patients. Given this evidence, non-steroidal MRAs are gaining momentum in the care, and particularly in individualized care, of CKD patients. CI - Copyright by Società Italiana di Nefrologia SIN, Rome, Italy. FAU - Provenzano, Michele AU - Provenzano M AD - Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy. FAU - De Nicola, Luca AU - De Nicola L AD - Nephrology-Dialysis Unit, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy. FAU - Gesualdo, Loreto AU - Gesualdo L AD - Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy. FAU - La Manna, Gaetano AU - La Manna G AD - Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy. LA - ita PT - English Abstract PT - Journal Article PT - Review DEP - 20221031 PL - Italy TA - G Ital Nefrol JT - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia JID - 9426434 RN - 0 (Mineralocorticoid Receptor Antagonists) RN - 0 (finerenone) RN - 0 (Naphthyridines) SB - IM MH - Humans MH - *Mineralocorticoid Receptor Antagonists/therapeutic use MH - *Renal Insufficiency, Chronic/complications/drug therapy/chemically induced MH - Naphthyridines/therapeutic use MH - Proteinuria/drug therapy OTO - NOTNLM OT - CKD OT - aldosterone OT - cardiovascular risk OT - epidemiology OT - iperkalaemia OT - kidney failure EDAT- 2022/12/24 06:00 MHDA- 2022/12/28 06:00 CRDT- 2022/12/23 12:22 PHST- 2022/12/23 12:22 [entrez] PHST- 2022/12/24 06:00 [pubmed] PHST- 2022/12/28 06:00 [medline] AID - 39-05-2022-01 [pii] PST - epublish SO - G Ital Nefrol. 2022 Oct 31;39(5):2022-vol5. PMID- 19520563 OWN - NLM STAT- MEDLINE DCOM- 20100108 LR - 20090925 IS - 1557-9816 (Electronic) IS - 0955-470X (Linking) VI - 23 IP - 4 DP - 2009 Oct TI - Renal transplantation in high cardiovascular risk patients. PG - 224-34 LID - 10.1016/j.trre.2009.02.001 [doi] AB - Current transplant success allows recipients with previous contraindications to transplant to have access to this procedure with more frequency and safety. The concept of high-risk patient has changed since the first stages of transplantation. In the first studies, the high-risk concept was based on probability of early graft failure or on a patient's clinical condition to cope with high perioperatory morbimortality. Later on, this concept implied immunological factors that were crucial to ensure transplant success because hypersensitized or polytransfused patients experienced a higher risk of acute rejection and subsequent graft loss. Afterward, the presence of various comorbidities would redefine the high-risk concept for renal transplant mainly considering recipient's clinical aspects. Currently, the change in epidemiological characteristics of patients starting dialysis causes that we now deal with a greater increase of elderly patients, diabetic patients, and patients with history of cardiovascular disease. Today, high-risk patients are those with clinical features that predict an increase in the risk of perioperative morbimortality or death with functioning graft. In this review, we will attempted to analyze currents results of renal transplant outcomes in terms of patients and graft survival in elderly patients, diabetic patients, and patients with previous cardiovascular disease from the most recent experiences in the literature and from experiences in our center. In any of the groups previously analyzed, survival offered by renal transplant is significantly higher compared to dialysis. Besides, these patients are the recipient group that benefit the most with the transplant because their mortality while remaining on dialysis is extremely high. Hence, renal transplantation should be offered more frequently to older patients, diabetic patients, and patients with pretransplant cardiac and peripheral vascular disease. A positive attitude toward renal transplantation is needed by physicians taking care of these patients from predialysis stages of chronic renal failure. FAU - Bittar, Julio AU - Bittar J AD - Renal Transplant Program, Hospital Privado- Centro Médico de Córdoba, 5016 Córdoba, Argentina. FAU - Arenas, Paula AU - Arenas P FAU - Chiurchiu, Carlos AU - Chiurchiu C FAU - de la Fuente, Jorge AU - de la Fuente J FAU - de Arteaga, Javier AU - de Arteaga J FAU - Douthat, Walter AU - Douthat W FAU - Massari, Pablo U AU - Massari PU LA - eng PT - Journal Article PT - Review DEP - 20090611 PL - United States TA - Transplant Rev (Orlando) JT - Transplantation reviews (Orlando, Fla.) JID - 8804364 SB - IM MH - Cardiovascular Diseases/*epidemiology MH - Comorbidity MH - Diabetes Mellitus/mortality MH - Diabetic Angiopathies/mortality MH - Humans MH - Kidney Diseases/*epidemiology/surgery MH - Kidney Transplantation/mortality/physiology/*statistics & numerical data MH - Risk Assessment MH - Risk Reduction Behavior MH - Survival Analysis MH - Survival Rate MH - Time Factors RF - 131 EDAT- 2009/06/13 09:00 MHDA- 2010/01/09 06:00 CRDT- 2009/06/13 09:00 PHST- 2009/06/13 09:00 [entrez] PHST- 2009/06/13 09:00 [pubmed] PHST- 2010/01/09 06:00 [medline] AID - S0955-470X(09)00018-4 [pii] AID - 10.1016/j.trre.2009.02.001 [doi] PST - ppublish SO - Transplant Rev (Orlando). 2009 Oct;23(4):224-34. doi: 10.1016/j.trre.2009.02.001. Epub 2009 Jun 11. PMID- 26736233 OWN - NLM STAT- MEDLINE DCOM- 20161011 LR - 20200928 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2015 DP - 2015 TI - Psycho-physiological tele-monitoring of human operators in commercial diving: The Life Support System in the SUONO project. PG - 194-7 LID - 10.1109/EMBC.2015.7318333 [doi] AB - Sea-diving operations for monitoring or intervention are carried out by highly-specialized divers called Certified Commercial Divers (CCD). CCDs operate under highly demanding working conditions in extreme and hazardous environments. Every day consists of an 8 hours' shift. To avoid decompression problems the remaining 16 hours are spent in a hyperbaric environment located aboard the surface vessel or on the platform. These operating conditions require the design of a technologically-advanced device for tele-monitoring, to maximize CCDs' safety. Here we describe a proposal for monitoring and supporting CCDs during operations. We design a dedicated Life Support System (LSS), that captures real-time, vital (heart rate, respiratory rate, accelerometry, etc) and stress-related (heart-rate variability) signals from operators to transmit them to dedicated servers via telematic protocols. LSS is equipped with protocols for tele-medicine/tele-consultation. Our system is being developed within the research project SUONO (Safe Underwater OperatioNs in Oceans). FAU - Laurino, Marco AU - Laurino M FAU - Guerriero, Lorenzo AU - Guerriero L FAU - Allegrini, Paolo AU - Allegrini P FAU - Menicucci, Danilo AU - Menicucci D FAU - Mastorci, Francesca AU - Mastorci F FAU - Magrin, Daniele AU - Magrin D FAU - Allotta, Benedetto AU - Allotta B FAU - Bedini, Remo AU - Bedini R FAU - Gemignani, Angelo AU - Gemignani A LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Diving/*physiology/*psychology MH - Equipment Design MH - Heart Rate MH - Humans MH - *Life Support Systems MH - Monitoring, Physiologic/instrumentation/*methods MH - Telemedicine/instrumentation/*methods EDAT- 2016/01/07 06:00 MHDA- 2016/10/12 06:00 CRDT- 2016/01/07 06:00 PHST- 2016/01/07 06:00 [entrez] PHST- 2016/01/07 06:00 [pubmed] PHST- 2016/10/12 06:00 [medline] AID - 10.1109/EMBC.2015.7318333 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2015;2015:194-7. doi: 10.1109/EMBC.2015.7318333. PMID- 34904198 OWN - NLM STAT- MEDLINE DCOM- 20211216 LR - 20211216 IS - 1573-2959 (Electronic) IS - 0167-6369 (Linking) VI - 194 IP - 1 DP - 2021 Dec 13 TI - Predicting factors of public awareness and perception about the quality, safety of drinking water, and pollution incidents. PG - 22 LID - 10.1007/s10661-021-09557-2 [doi] AB - Public perception of drinking water quality and safety results from the interaction of multiple factors, including the public engagement, which requires sufficient knowledge and awareness. This issue has yet to be addressed in Algeria. This study investigated the residents' perception and awareness about the drinking water quality, safety, and water pollution events. A survey-based cross-sectional study was conducted amongst citizens living in the province of Biskra. Multinomial regression analysis was used to identify the predicted public perception factors about drinking water-related issues. Regardless of the degree of public trust in the drinking water sources, the main drinking water source reported by the participants was tank water (43.3%) followed by tap water (32%). Water quality standards are a measure of the condition of water relative to the contaminants. Water consumption profiles gave priority attention to taste (48.7%), odour (35%), appearance (34.7%), and colour (32%), reflecting a low level of knowledge about the water quality standards. Most of the residents (55.7%) reported a deficient communication about the preventive measures to protect public health. The higher level of education showed a statistically significant impact in discriminating between those who felt very satisfied and dissatisfied participants with the drinking water quality and those who felt between satisfied and dissatisfied (P = 0.023, P = 0.034, respectively). Additionally, education level had a statistically significant role in differentiating trust levels in drinking water quality between two groups, those belonging to either confident or relatively confident and the group of extremely worried respondents, with P = 0.000 and P = 0.000, respectively. Interviewed respondents with certain education levels showed higher trust in the safety of drinking water when compared to those with lower education levels. Gender had a significant role in differentiating the group of respondents who were relatively confident from those who were extremely worried (P = 0.016). The public knowledge about the standards of water quality, safety, and the pollution-related issues remains relatively low. This study is of interest to policy makers and public health authorities who implement actions for water contamination prevention and public health protection. These findings could have national implications and are also applicable, in general context, particularly in low and middle-income countries. CI - © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Benameur, Tarek AU - Benameur T AD - College of Medicine, King Faisal University, P.O. Box 380, Al Ahsa, Kingdom of Saudi Arabia. tbenameur@kfu.edu.sa. FAU - Benameur, Nassima AU - Benameur N AD - Faculty of Exact Sciences and Sciences of Nature and Life, Research Laboratory of Civil Engineering, Hydraulics, Sustainable Development and Environment (LARGHYDE), Mohamed Khider University, Biskra, Algeria. FAU - Saidi, Neji AU - Saidi N AD - College of Sciences, King Faisal University, P.O. Box 380, Al Ahsa, Kingdom of Saudi Arabia. FAU - Tartag, Sakina AU - Tartag S AD - Faculty of Exact Sciences and Sciences of Nature and Life, Research Laboratory of Civil Engineering, Hydraulics, Sustainable Development and Environment (LARGHYDE), Mohamed Khider University, Biskra, Algeria. FAU - Sayad, Hadjer AU - Sayad H AD - Faculty of Exact Sciences and Sciences of Nature and Life, Research Laboratory of Civil Engineering, Hydraulics, Sustainable Development and Environment (LARGHYDE), Mohamed Khider University, Biskra, Algeria. FAU - Agouni, Abdelali AU - Agouni A AD - Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. AD - Biomedical and Pharmaceutical Research Unit (BPRU), QU Health, Qatar University, Doha, Qatar. AD - Office of Vice President for Research and Graduate Studies, Qatar University, Doha, Qatar. LA - eng PT - Journal Article DEP - 20211213 PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 0 (Drinking Water) SB - IM MH - Cross-Sectional Studies MH - *Drinking Water MH - Environmental Monitoring MH - Humans MH - Perception MH - Water Pollution MH - Water Quality MH - Water Supply OTO - NOTNLM OT - Awareness OT - Contamination OT - Environmental protection OT - Perception OT - Pollution OT - Public health OT - Water quality OT - Water safety EDAT- 2021/12/15 06:00 MHDA- 2021/12/17 06:00 CRDT- 2021/12/14 08:27 PHST- 2020/09/22 00:00 [received] PHST- 2021/10/19 00:00 [accepted] PHST- 2021/12/14 08:27 [entrez] PHST- 2021/12/15 06:00 [pubmed] PHST- 2021/12/17 06:00 [medline] AID - 10.1007/s10661-021-09557-2 [pii] AID - 10.1007/s10661-021-09557-2 [doi] PST - epublish SO - Environ Monit Assess. 2021 Dec 13;194(1):22. doi: 10.1007/s10661-021-09557-2. PMID- 31285700 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200225 IS - 1188-4169 (Print) IS - 1481-8531 (Electronic) IS - 1188-4169 (Linking) VI - 45 IP - 4 DP - 2019 Apr 4 TI - How will climate change impact microbial foodborne disease in Canada? PG - 108-113 LID - 10.14745/ccdr.v45i04a05 [doi] AB - Foodborne disease is a major concern in Canada and represents a significant climate change-related threat to public health. Climate variables, including temperature and precipitation patterns, extreme weather events and ocean warming and acidification, are known to exert significant, complicated and interrelated effects along the entire length of the food chain. Foodborne diseases are caused by a range of bacteria, fungi, parasites and viruses, and the prevalence of these diseases is modified by climate change through alterations in the abundance, growth, range and survival of many pathogens, as well as through alterations in human behaviours and in transmission factors such as wildlife vectors. As climate change continues and/or intensifies, it will increase the risk of an adverse effect on food safety in Canada ranging from increased public health burden to the emergence of risks not currently seen in our food chain. Clinical and public health practitioners need to be aware of the existing and emerging risks to respond accordingly. FAU - Smith, B A AU - Smith BA AD - National Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON. FAU - Fazil, A AU - Fazil A AD - National Microbiology Laboratory, Public Health Agency of Canada, Guelph, ON. LA - eng PT - Journal Article DEP - 20190404 PL - Canada TA - Can Commun Dis Rep JT - Canada communicable disease report = Releve des maladies transmissibles au Canada JID - 9303729 PMC - PMC6587690 OTO - NOTNLM OT - Canada OT - climate change OT - food safety OT - foodborne disease COIS- Conflict of interest: None. EDAT- 2019/07/10 06:00 MHDA- 2019/07/10 06:01 PMCR- 2019/04/04 CRDT- 2019/07/10 06:00 PHST- 2019/07/10 06:00 [entrez] PHST- 2019/07/10 06:00 [pubmed] PHST- 2019/07/10 06:01 [medline] PHST- 2019/04/04 00:00 [pmc-release] AID - 450405 [pii] AID - 10.14745/ccdr.v45i04a05 [doi] PST - epublish SO - Can Commun Dis Rep. 2019 Apr 4;45(4):108-113. doi: 10.14745/ccdr.v45i04a05. eCollection 2019 Apr 4. PMID- 36795872 OWN - NLM STAT- MEDLINE DCOM- 20230222 LR - 20230306 IS - 1538-6899 (Electronic) IS - 1080-2371 (Linking) VI - 29 IP - 1 DP - 2023 Feb 1 TI - Safety Considerations in MRI and CT. PG - 27-53 LID - 10.1212/CON.0000000000001213 [doi] AB - OBJECTIVE: MRI and CT are indispensable imaging modalities for the evaluation of patients with neurologic disease, and each is particularly well suited to address specific clinical questions. Although both of these imaging modalities have excellent safety profiles in clinical use as a result of concerted and dedicated efforts, each has potential physical and procedural risks that the practitioner should be aware of, which are described in this article. LATEST DEVELOPMENTS: Recent advancements have been made in understanding and reducing safety risks with MR and CT. The magnetic fields in MRI create risks for dangerous projectile accidents, radiofrequency burns, and deleterious interactions with implanted devices, and serious patient injuries and deaths have occurred. Ionizing radiation in CT may be associated with shorter-term deterministic effects on biological tissues at extremely high doses and longer-term stochastic effects related to mutagenesis and carcinogenesis at low doses. The cancer risk of radiation exposure in diagnostic CT is considered extremely low, and the benefit of an appropriately indicated CT examination far outweighs the potential risk. Continuing major efforts are centered on improving image quality and the diagnostic power of CT while concurrently keeping radiation doses as low as reasonably achievable. ESSENTIAL POINTS: An understanding of these MRI and CT safety issues that are central to contemporary radiology practice is essential for the safe and effective treatment of patients with neurologic disease. CI - Copyright © 2023 American Academy of Neurology. FAU - Watson, Robert E AU - Watson RE FAU - Yu, Lifeng AU - Yu L LA - eng PT - Journal Article PL - United States TA - Continuum (Minneap Minn) JT - Continuum (Minneapolis, Minn.) JID - 9509333 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/adverse effects MH - Risk MH - *Tomography, X-Ray Computed/adverse effects EDAT- 2023/02/17 06:00 MHDA- 2023/02/22 06:00 CRDT- 2023/02/16 14:13 PHST- 2023/02/16 14:13 [entrez] PHST- 2023/02/17 06:00 [pubmed] PHST- 2023/02/22 06:00 [medline] AID - 00132979-202302000-00005 [pii] AID - 10.1212/CON.0000000000001213 [doi] PST - ppublish SO - Continuum (Minneap Minn). 2023 Feb 1;29(1):27-53. doi: 10.1212/CON.0000000000001213. PMID- 34122732 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210615 IS - 1948-9366 (Print) IS - 1948-9366 (Electronic) VI - 13 IP - 5 DP - 2021 May 27 TI - Feasibility and safety of "bridging" pancreaticogastrostomy for pancreatic trauma in Landrace pigs. PG - 419-428 LID - 10.4240/wjgs.v13.i5.419 [doi] AB - BACKGROUND: In recent years, we created and employed a new anastomosis method, "bridging" pancreaticogastrostomy, to treat patients with extremely severe pancreatic injury. This surgery has advantages such as short length of surgery, low secondary trauma, rapid construction of shunts for pancreatic fluid, preventing second surgeries, and achieving good treatment outcomes in clinical practice. However, due to the limited number of clinical cases, there is a lack of strong evidence to support the feasibility and safety of this surgical procedure. Therefore, we carried out animal experiments to examine this procedure, which is reported here. AIM: To examine the feasibility and safety of a new rapid method of pancreaticogastrostomy, "bridging" pancreaticogastrostomy. METHODS: Ten Landrace pigs were randomized into the experimental and control groups, with five pigs in each group. "Bridging" pancreaticogastrostomy was performed in the experimental group, while routine mucosa-to-mucosa pancreaticogastrostomy was performed in the control group. After surgery, the general condition, amylase levels in drainage fluid on Days 1, 3, 5, and 7, fasting and 2-h postprandial blood glucose 6 mo after surgery, fasting, 2-h postprandial peripheral blood insulin, and portal vein blood insulin 6 mo after surgery were assessed. Resurgery was carried out at 1 and 6 mo after the former one to examine the condition of the abdominal cavity and firmness and tightness of the pancreaticogastric anastomosis and pancreas. RESULTS: After surgery, the general condition of the animals was good. One in the control group did not gain weight 6 mo after surgery, whereas significant weight gain was present in the others. There were significant differences on Days 1 and 3 after surgery between the two groups but no differences on Days 5 and 7. There were no differences in fasting and 2-h postprandial blood glucose and fasting and 2-h insulin values of postprandial peripheral blood and portal vein blood 6 mo after surgery between the two groups. One month after surgery, the sinus tract orifice/anastomosis was patent in the two groups. Six months after surgery, the sinus tract orifice/anastomosis was sealed, and pancreases in both groups presented with chronic pancreatitis. CONCLUSION: "Bridging" pancreaticogastrostomy is a feasible and safe a means of damage control surgery during the early stage of pancreatic injury. CI - ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Feng, Jian AU - Feng J AD - Department of Hepatopancreatobiliary Surgery, Peking University Shougang Hospital, Beijing 100144, China. FAU - Zhang, Hang-Yu AU - Zhang HY AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Yan, Li AU - Yan L AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Zhu, Zi-Man AU - Zhu ZM AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Liang, Bin AU - Liang B AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Wang, Peng-Fei AU - Wang PF AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Zhao, Xiang-Qian AU - Zhao XQ AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. FAU - Chen, Yong-Liang AU - Chen YL AD - Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China. chenyongl301@163.com. LA - eng PT - Journal Article PL - United States TA - World J Gastrointest Surg JT - World journal of gastrointestinal surgery JID - 101532473 PMC - PMC8167843 OTO - NOTNLM OT - Damage control surgery OT - Pancreatic trauma OT - Safety OT - Severe pancreatic injury OT - “Bridging” pancreaticogastrostomy COIS- Conflict-of-interest statement: No conflict of interest. EDAT- 2021/06/15 06:00 MHDA- 2021/06/15 06:01 PMCR- 2021/05/27 CRDT- 2021/06/14 09:40 PHST- 2021/01/12 00:00 [received] PHST- 2021/02/19 00:00 [revised] PHST- 2021/04/26 00:00 [accepted] PHST- 2021/06/14 09:40 [entrez] PHST- 2021/06/15 06:00 [pubmed] PHST- 2021/06/15 06:01 [medline] PHST- 2021/05/27 00:00 [pmc-release] AID - 10.4240/wjgs.v13.i5.419 [doi] PST - ppublish SO - World J Gastrointest Surg. 2021 May 27;13(5):419-428. doi: 10.4240/wjgs.v13.i5.419. PMID- 10769821 OWN - NLM STAT- MEDLINE DCOM- 20000608 LR - 20190921 IS - 0161-6412 (Print) IS - 0161-6412 (Linking) VI - 22 IP - 3 DP - 2000 Apr TI - Future trends in spinal cord stimulation. PG - 279-84 AB - Spinal cord stimulation (SCS) has been available for about 30 years, but only in the past five years has it met with widespread acceptance and recognition by the medical community. Traditionally performed by neurosurgeons, SCS is being increasingly utilized by anesthesiologists, orthopedic surgeons and physiatrists. Pain management continues to be the most widespread application of SCS. More sophisticated technology has allowed the implanters to successfully address more complex pain syndromes such as widespread reflex sympathetic dystrophy and the failed back syndrome. Other applications are being developed, combining the ability to stimulate the spinal cord, the nerve roots and the peripheral nerves. Examples include angina pectoris, urinary incontinence and occipital neuralgia. Computer-interactive programming is gaining popularity, especially due to the extreme complexity of the implanted stimulation devices. The ability to stimulate independently multiple channels as well as multiple arrays of electrodes is today a reality. This has increased greatly the efficacy, safety and reliability of the modality. In the future, SCS will undoubtedly move several steps up in the treatment ladder of chronic pain conditions, while new applications will be discovered. The future of neural implantable technologies is bright, with an increasingly important role in the medical management of chronic conditions affecting the nervous system. FAU - Barolat, G AU - Barolat G AD - Department of Neurosurgery, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA. FAU - Sharan, A D AU - Sharan AD LA - eng PT - Journal Article PT - Review PL - England TA - Neurol Res JT - Neurological research JID - 7905298 SB - IM MH - Angina Pectoris/physiopathology MH - Animals MH - *Electric Stimulation Therapy/trends MH - Humans MH - *Pain Management MH - *Spinal Cord MH - Transcutaneous Electric Nerve Stimulation RF - 56 EDAT- 2000/04/19 09:00 MHDA- 2000/06/10 09:00 CRDT- 2000/04/19 09:00 PHST- 2000/04/19 09:00 [pubmed] PHST- 2000/06/10 09:00 [medline] PHST- 2000/04/19 09:00 [entrez] AID - 10.1080/01616412.2000.11740671 [doi] PST - ppublish SO - Neurol Res. 2000 Apr;22(3):279-84. doi: 10.1080/01616412.2000.11740671. PMID- 34424842 OWN - NLM STAT- MEDLINE DCOM- 20211011 LR - 20211011 IS - 2154-2317 (Electronic) IS - 2154-2287 (Linking) VI - 12 IP - 4 DP - 2021 Jul-Aug TI - Novel Health Risk Alert System for Occupational Safety in Hot Environments. PG - 24-27 LID - 10.1109/MPULS.2021.3094253 [doi] AB - The last century has seen a gradual increase in global average temperatures-a phenomenon that has come to be known as global warming. The World Meteorological Organization (WMO) has reported that 2020 was one of the three warmest years on record and that the global average temperature was ~1.2°C above preindustrial (1850-1900) levels [1]. Adverse effects on health resulting from global warming are important issues to consider, as health risks associated with such extreme heat are anticipated [2]. In fact, this warming has been shown to severely limit human activity in tropical and mid-latitude regions [3], and in particular, outdoor and manual workers who are exposed to ambient heat during working hours are susceptible to increased health risks. Thus, workers should pay attention to their own physical conditions and proactively keep out of the heat to rest when uncomfortable. Additionally, supervisors must manage worker's physical conditions and schedule regular breaks. Therefore, in this trial a new integrated system was developed to notify individuals at risk based on their thermal physiology. This method uses biological and environmental information obtained directly via wearable sensors and the estimated body core temperature collected on-ground cannot be measured wirelessly and noninvasively [4]. FAU - Togo, Hiroyoshi AU - Togo H FAU - Hirata, Akimasa AU - Hirata A LA - eng PT - Journal Article PL - United States TA - IEEE Pulse JT - IEEE pulse JID - 101541727 SB - IM MH - Body Temperature MH - Global Warming MH - *Heat Stress Disorders MH - Hot Temperature/*adverse effects MH - Humans MH - *Monitoring, Physiologic MH - *Occupational Health MH - Risk Assessment MH - Wearable Electronic Devices EDAT- 2021/08/24 06:00 MHDA- 2021/10/12 06:00 CRDT- 2021/08/23 17:32 PHST- 2021/08/23 17:32 [entrez] PHST- 2021/08/24 06:00 [pubmed] PHST- 2021/10/12 06:00 [medline] AID - 10.1109/MPULS.2021.3094253 [doi] PST - ppublish SO - IEEE Pulse. 2021 Jul-Aug;12(4):24-27. doi: 10.1109/MPULS.2021.3094253. PMID- 23140510 OWN - NLM STAT- MEDLINE DCOM- 20131017 LR - 20131106 IS - 1746-045X (Electronic) IS - 1746-0441 (Linking) VI - 8 IP - 1 DP - 2013 Jan TI - Network approaches to drug discovery. PG - 7-20 LID - 10.1517/17460441.2013.741119 [doi] AB - INTRODUCTION: Advances in genomics technologies are providing a very large amount of data on genome-wide gene expression profiles, protein molecules and their interactions with other macromolecules and metabolites. Molecular interaction networks provide a useful way to capture this complex data and comprehend it. Networks are beginning to be used in drug discovery, in many steps of the modern discovery pipeline, with large-scale molecular networks being particularly useful for the understanding of the molecular basis of the disease. AREAS COVERED: The authors discuss network approaches used for drug target discovery and lead identification in the drug discovery pipeline. By reconstructing networks of targets, drugs and drug candidates as well as gene expression profiles under normal and disease conditions, the paper illustrates how it is possible to find relationships between different diseases, find biomarkers, explore drug repurposing and study emergence of drug resistance. Furthermore, the authors also look at networks which address particular important aspects such as off-target effects, combination-targets, mechanism of drug action and drug safety. EXPERT OPINION: The network approach represents another paradigm shift in drug discovery science. A network approach provides a fresh perspective of understanding important proteins in the context of their cellular environments, providing a rational basis for deriving useful strategies in drug design. Besides drug target identification and inferring mechanism of action, networks enable us to address new ideas that could prove to be extremely useful for new drug discovery, such as drug repositioning, drug synergy, polypharmacology and personalized medicine. FAU - Chandra, Nagasuma AU - Chandra N AD - Indian Institute of Science, Department of Biochemistry, Bangalore - 560012 , India. nchandra@biochem.iisc.ernet.in FAU - Padiadpu, Jyothi AU - Padiadpu J LA - eng PT - Journal Article PT - Review DEP - 20121110 PL - England TA - Expert Opin Drug Discov JT - Expert opinion on drug discovery JID - 101295755 SB - IM MH - Animals MH - Drug Discovery/*methods/trends MH - Genomics/methods/trends MH - Humans MH - *Information Services/trends MH - *Models, Biological MH - Protein Interaction Maps/genetics EDAT- 2012/11/13 06:00 MHDA- 2013/10/18 06:00 CRDT- 2012/11/13 06:00 PHST- 2012/11/13 06:00 [entrez] PHST- 2012/11/13 06:00 [pubmed] PHST- 2013/10/18 06:00 [medline] AID - 10.1517/17460441.2013.741119 [doi] PST - ppublish SO - Expert Opin Drug Discov. 2013 Jan;8(1):7-20. doi: 10.1517/17460441.2013.741119. Epub 2012 Nov 10. PMID- 11213859 OWN - NLM STAT- MEDLINE DCOM- 20010503 LR - 20190915 IS - 0277-0008 (Print) IS - 0277-0008 (Linking) VI - 21 IP - 2 DP - 2001 Feb TI - Dosing and monitoring of low-molecular-weight heparins in special populations. PG - 218-34 AB - As a result of numerous clinical trials and meta-analyses supporting the superior efficacy and relative safety of low-molecular-weight heparins (LMWHs) compared with unfractionated heparin (UFH), LMWHs are emerging as the antithrombotic agents of choice for the prevention and treatment of deep vein thrombosis and pulmonary embolism. In addition, data indicate that enoxaparin given with low-dosage aspirin is more effective than UFH in treating acute coronary syndromes. Anti-Xa activity can be used as a biologic marker of LMWH activity. Because of the more predictable anticoagulant response to subcutaneous administration of LMWHs compared with UFH, routine monitoring of anti-Xa activity in clinically stable adults with uncomplicated disease is not recommended. Because the optimal dosage of LMWHs has not been established for patients with renal insufficiency or extremes of body weight, during pregnancy, or for children, anti-Xa activity monitoring may be warranted in these subsets. FAU - Duplaga, B A AU - Duplaga BA AD - Pharmacy Services, Washington County Health System, Hagerstown, Maryland, USA. FAU - Rivers, C W AU - Rivers CW FAU - Nutescu, E AU - Nutescu E LA - eng PT - Journal Article PT - Review PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 RN - 0 (Anticoagulants) RN - 0 (Heparin, Low-Molecular-Weight) RN - EC 3.4.21.6 (Factor Xa) SB - IM MH - Anticoagulants/*administration & dosage/pharmacokinetics MH - Body Weight/drug effects/physiology MH - Child MH - Child, Preschool MH - Clinical Trials as Topic MH - Coronary Disease/blood/*drug therapy MH - *Drug Monitoring MH - Factor Xa/*drug effects/metabolism MH - Female MH - Heparin, Low-Molecular-Weight/*administration & dosage/pharmacokinetics MH - Humans MH - Pregnancy/blood/*drug effects MH - Renal Insufficiency/*blood MH - Venous Thrombosis/blood/*drug therapy RF - 130 EDAT- 2001/02/24 12:00 MHDA- 2001/05/05 10:01 CRDT- 2001/02/24 12:00 PHST- 2001/02/24 12:00 [pubmed] PHST- 2001/05/05 10:01 [medline] PHST- 2001/02/24 12:00 [entrez] AID - 10.1592/phco.21.2.218.34112 [doi] PST - ppublish SO - Pharmacotherapy. 2001 Feb;21(2):218-34. doi: 10.1592/phco.21.2.218.34112. PMID- 38398273 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240227 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 13 IP - 4 DP - 2024 Feb 7 TI - Efficacy and Safety of the Extreme Lateral Interbody Fusion (XLIF) Technique in Spine Surgery: Meta-Analysis of 1409 Patients. LID - 10.3390/jcm13040960 [doi] LID - 960 AB - (1) Objectives: The objective of this study was to quantify the exact clinical-radiological efficacy and safety of the extreme lateral interbody fusion (XLIF) technique in spinal surgery; (2) Methods: A meta-analysis was performed using PubMed, Embase, Scopus, and Cochrane Collaboration Library. Studies focusing on patients surgically treated with XLIF were included. The outcomes were as follows: visual analog scale (VAS) and Oswestry disability index (ODI), radiological outcomes, and adverse events. Cohort studies and case series were also included. Clinical outcomes were assessed at 12 months of age. Data were combined using Review Manager 5.4 and WebPlotDigitizer 13.1.4; (3) Results: Nineteen studies with a pool of 1409 patients were included in this meta-analysis. Leg pain VAS and back pain VAS significantly improved at 12 months (SMD 2.75, 95% CI 0.59-4.90; SMD 4.54, 95% CI 1.39-7.69). ODI showed significant improvement (MD 32.51, 95% CI 24.01-41.00) at 12 months. Disc height increased significantly (SMD -2.73, 95% CI -3.58 to -1.88). Lumbar lordosis and segmental lordosis were significantly corrected postoperatively (MD -2.44, 95% CI -3.45 to -1.43; MD -2.55, 95% CI -3.61 to -1.48). The fusion rates at 12 months ranged from 85.0% to 93.3%. The most frequent complications were transient neurological conditions (2.2%), hardware failure (1.9%), and transient pain (1.8%). The most frequent serious complications were nerve root injury (1.0%), gastrointestinal impairment (0.7%), and vertebral fractures (0.6%); (4) Conclusions: This is the first meta-analysis of the specific use of XLIF in spinal surgery. This study demonstrates that the XLIF technique in spine surgery is associated with good clinical and radiological results and a low complication rate. FAU - Palacios, Pablo AU - Palacios P AD - Department of Traumatology and Orthopaedic Surgery, University Hospital HM Sanchinarro, 28050 Madrid, Spain. FAU - Palacios, Isabel AU - Palacios I AD - Department of Traumatology and Orthopaedic Surgery, University Hospital HM Sanchinarro, 28050 Madrid, Spain. FAU - Palacios, Ana AU - Palacios A AD - Department of Traumatology and Orthopaedic Surgery, University Hospital HM Sanchinarro, 28050 Madrid, Spain. FAU - Gutiérrez, Juan Carlos AU - Gutiérrez JC AD - Department of Traumatology and Orthopaedic Surgery, University Hospital HM Sanchinarro, 28050 Madrid, Spain. FAU - Mariscal, Gonzalo AU - Mariscal G AUID- ORCID: 0000-0002-5166-198X AD - Institute for Research on Musculoskeletal Disorders, Valencia Catholic University, 46001 Valencia, Spain. FAU - Lorente, Alejandro AU - Lorente A AD - Department of Traumatology and Orthopaedic Surgery, University Hospital Ramón y Cajal, 28034 Madrid, Spain. LA - eng PT - Journal Article PT - Review DEP - 20240207 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC10889658 OTO - NOTNLM OT - XLIF OT - extreme lateral interbody fusion OT - meta-analysis OT - minimally invasive OT - spine surgery COIS- The authors declare no conflicts of interest. EDAT- 2024/02/24 11:45 MHDA- 2024/02/24 11:46 PMCR- 2024/02/07 CRDT- 2024/02/24 01:12 PHST- 2024/01/11 00:00 [received] PHST- 2024/01/30 00:00 [revised] PHST- 2024/02/06 00:00 [accepted] PHST- 2024/02/24 11:46 [medline] PHST- 2024/02/24 11:45 [pubmed] PHST- 2024/02/24 01:12 [entrez] PHST- 2024/02/07 00:00 [pmc-release] AID - jcm13040960 [pii] AID - jcm-13-00960 [pii] AID - 10.3390/jcm13040960 [doi] PST - epublish SO - J Clin Med. 2024 Feb 7;13(4):960. doi: 10.3390/jcm13040960. PMID- 19104316 OWN - NLM STAT- MEDLINE DCOM- 20090324 LR - 20081223 IS - 1539-0683 (Electronic) IS - 0361-929X (Linking) VI - 34 IP - 1 DP - 2009 Jan-Feb TI - Caring for the extremely obese woman during pregnancy and birth. PG - 24-30 LID - 10.1097/01.NMC.0000343862.72237.62 [doi] AB - This article describes the special care needed by the pregnant woman who is extremely obese. Many pregnant women who are extremely obese have underlying medical conditions, and a multidisciplinary, coordinated approach to their care involving anesthesia providers, physicians, and the nursing staff is needed to develop a detailed plan for vaginal and cesarean births. Such an approach, begun preconceptionally or during pregnancy, can enable care to be delivered smoothly and safely and should include an evaluation of the unit's equipment and furniture to determine if they are appropriate for obese persons. Equipment that should be evaluated for size and weight limits include beds, operating room tables, commodes, wheelchairs, scales, walkers, blood pressure cuffs, transfer devices, and intermittent pneumatic compression devices. FAU - James, Dotti C AU - James DC AD - Center for Nursing Excellence, St. John's Mercy Medical Center, St. Louis, MO, USA. Dotti.james@mercy.net FAU - Maher, Mary Ann AU - Maher MA LA - eng PT - Journal Article PT - Review PL - United States TA - MCN Am J Matern Child Nurs JT - MCN. The American journal of maternal child nursing JID - 7605941 SB - IM MH - Adult MH - Bariatric Surgery MH - Cesarean Section MH - Delivery, Obstetric/*methods MH - Equipment Safety MH - Female MH - Humans MH - Infant, Newborn MH - Interdisciplinary Communication MH - Obesity, Morbid/*complications/surgery/therapy MH - *Patient Care Planning MH - Patient Care Team MH - Pregnancy MH - Pregnancy Complications/etiology/*prevention & control MH - Prenatal Care/*standards MH - Risk Factors MH - Weight Gain/physiology MH - Young Adult RF - 30 EDAT- 2008/12/24 09:00 MHDA- 2009/03/25 09:00 CRDT- 2008/12/24 09:00 PHST- 2008/12/24 09:00 [entrez] PHST- 2008/12/24 09:00 [pubmed] PHST- 2009/03/25 09:00 [medline] AID - 10.1097/01.NMC.0000343862.72237.62 [doi] PST - ppublish SO - MCN Am J Matern Child Nurs. 2009 Jan-Feb;34(1):24-30. doi: 10.1097/01.NMC.0000343862.72237.62. PMID- 18615122 OWN - NLM STAT- MEDLINE DCOM- 20080904 LR - 20080710 IS - 1139-6121 (Print) IS - 1139-6121 (Linking) VI - 10 IP - 2 DP - 2008 Apr-Jun TI - Restorative interventions for HIV facial lipoatrophy. PG - 116-24 AB - Facial lipoatrophy is a common and distressing manifestation of HIV lipodystrophy. The changes in facial appearance can reduce quality of life, self esteem and antiretroviral adherence. Apart from the modest benefits of thymidine-based nucleoside analog cessation, there are no proven therapies for lipoatrophy. Management of established fat loss can be challenging as restoration of lost fat mass is extremely gradual. Plastic surgery and cosmetic procedures can restore lost facial volume. Both biodegradable and permanent filling agents have been investigated for HIV facial lipoatrophy. Biodegradable products offer a good safety profile, but maintenance of aesthetic benefits necessitates reinjection over time. Although permanent products offer longevity and lower treatment costs, adverse events should they occur can be serious and of long duration. Despite the substantial increase in options for soft-tissue augmentation in recent years, well-performed clinical studies in HIV-infected adults with facial lipoatrophy are scarce, and long-term clinical safety data are lacking. This review will summarize available efficacy and safety data of the biodegradable and permanent agents utilized for soft-tissue augmentation in this population. Difficulties associated with comparing treatment efficacy data, assessment of facial lipoatrophy presence and severity, and measurement of facial fat will be discussed. Available data indicate that in HIV-infected adults, most filling agents have short-term clinically safety, and can provide aesthetic improvement and improve well-being, social functioning and quality of life. However, well-designed studies with objectively assessed endpoints are needed to elucidate optimal treatments for this distressing condition. FAU - Carey, Dianne AU - Carey D AD - National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, Australia. dcarey@nchecr.unsw.edu.au FAU - Liew, Steven AU - Liew S FAU - Emery, Sean AU - Emery S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Spain TA - AIDS Rev JT - AIDS reviews JID - 101134876 SB - IM MH - Absorbable Implants/adverse effects MH - Face/*surgery MH - HIV Infections/*complications MH - HIV-Associated Lipodystrophy Syndrome/*surgery MH - Humans MH - Prostheses and Implants/adverse effects RF - 70 EDAT- 2008/07/11 09:00 MHDA- 2008/09/05 09:00 CRDT- 2008/07/11 09:00 PHST- 2008/07/11 09:00 [pubmed] PHST- 2008/09/05 09:00 [medline] PHST- 2008/07/11 09:00 [entrez] PST - ppublish SO - AIDS Rev. 2008 Apr-Jun;10(2):116-24. PMID- 25108018 OWN - NLM STAT- MEDLINE DCOM- 20150630 LR - 20231213 IS - 1470-2738 (Electronic) IS - 0143-005X (Linking) VI - 68 IP - 12 DP - 2014 Dec TI - Extreme temperatures and out-of-hospital coronary deaths in six large Chinese cities. PG - 1119-24 LID - 10.1136/jech-2014-204012 [doi] AB - BACKGROUND: The seasonal trend of out-of-hospital coronary death (OHCD) and sudden cardiac death has been observed, but whether extreme temperature serves as a risk factor is rarely investigated. We therefore aimed to evaluate the impact of extreme temperatures on OHCDs in China. We obtained death records of 126,925 OHCDs from six large Chinese cities (Harbin, Beijing, Tianjin, Nanjing, Shanghai and Guangzhou) during the period 2009-2011. METHODS: The short-term associations between extreme temperature and OHCDs were analysed with time-series methods in each city, using generalised additive Poisson regression models. We specified distributed lag non-linear models in studying the delayed effects of extreme temperature. We then applied Bayesian hierarchical models to combine the city-specific effect estimates. RESULTS: The associations between extreme temperature and OHCDs were almost U-shaped or J-shaped. The pooled relative risks (RRs) of extreme cold temperatures over the lags 0-14 days comparing the 1st and 25th centile temperatures were 1.49 (95% posterior interval (PI) 1.26-1.76); the pooled RRs of extreme hot temperatures comparing the 99th and 75th centile temperatures were 1.53 (95% PI 1.27-1.84) for OHCDs. The RRs of extreme temperature on OHCD were higher if the patients with coronary heart disease were old, male and less educated. CONCLUSIONS: This multicity epidemiological study suggested that both extreme cold and hot temperatures posed significant risks on OHCDs, and might have important public health implications for the prevention of OHCD or sudden cardiac death. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, & Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China Research Institute for the Changing Global Environment and Fudan Tyndall Centre, Fudan University, Shanghai, China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP), Fudan University, Shanghai, China. FAU - Li, Tiantian AU - Li T AD - Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Cai, Jing AU - Cai J AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, & Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China Research Institute for the Changing Global Environment and Fudan Tyndall Centre, Fudan University, Shanghai, China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP), Fudan University, Shanghai, China. FAU - Yan, Meilin AU - Yan M AD - College of Environmental Sciences and Engineering, Peking University, Beijing, China. FAU - Zhao, Zhuohui AU - Zhao Z AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, & Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, & Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai, China Research Institute for the Changing Global Environment and Fudan Tyndall Centre, Fudan University, Shanghai, China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP), Fudan University, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140808 PL - England TA - J Epidemiol Community Health JT - Journal of epidemiology and community health JID - 7909766 RN - 0 (Air Pollutants) SB - IM MH - Aged MH - Air Pollutants/adverse effects/analysis MH - China/epidemiology MH - Extreme Cold/*adverse effects MH - Extreme Heat/*adverse effects MH - Female MH - Humans MH - Male MH - Middle Aged MH - Out-of-Hospital Cardiac Arrest/*mortality MH - Urban Population OTO - NOTNLM OT - BIOSTATISTICS OT - CLIMATE CHANGE OT - Clinical epidemiology OT - Environmental epidemiology EDAT- 2014/08/12 06:00 MHDA- 2015/07/01 06:00 CRDT- 2014/08/10 06:00 PHST- 2014/08/10 06:00 [entrez] PHST- 2014/08/12 06:00 [pubmed] PHST- 2015/07/01 06:00 [medline] AID - jech-2014-204012 [pii] AID - 10.1136/jech-2014-204012 [doi] PST - ppublish SO - J Epidemiol Community Health. 2014 Dec;68(12):1119-24. doi: 10.1136/jech-2014-204012. Epub 2014 Aug 8. PMID- 32436288 OWN - NLM STAT- MEDLINE DCOM- 20210728 LR - 20210728 IS - 1365-2125 (Electronic) IS - 0306-5251 (Linking) VI - 87 IP - 1 DP - 2021 Jan TI - Development of prescribing safety indicators related to mental health disorders and medications: Modified e-Delphi study. PG - 189-209 LID - 10.1111/bcp.14391 [doi] AB - AIM: To develop a set of prescribing safety indicators related to mental health disorders and medications, and to estimate the risk of harm associated with each indicator. METHOD: A modified two-stage electronic Delphi. The first stage consisted of two rounds in which 31 experts rated their agreement with a set of 101 potential mental health related prescribing safety indicators using a five-point scale and given the opportunity to suggest other indicators. Indicators that achieved 80% agreement were accepted. The second stage comprised a single round in which 29 members estimated the risk of harm for each accepted indicator by assessing the occurrence likelihood and outcome severity using two five-point scales. Indicators were considered high or extreme risk when at least 80% of participants rated each indicator as high or extreme. RESULTS: Seventy-five indicators were accepted in the first stage. Following the second stage, 42 (56%) were considered to be high or extreme risk for patient care. The 42 indicators comprised different types of hazardous prescribing, including drug-disease interactions (n = 12), drug-drug interactions (n = 9), inadequate monitoring (n = 5), inappropriate duration (n = 4), inappropriate dose (n = 4), omissions (n = 4), potentially inappropriate medications (n = 3) and polypharmacy (n = 1). These indicators also covered different mental health related medication classes, including antipsychotics (n = 14), mood stabilisers (n = 8), antidepressants (n = 6), sedative, hypnotics and anxiolytics (n = 6), anticholinergic (n = 6) and nonspecific psychotropics (n = 2). CONCLUSION: This study has developed the first suite of prescribing safety indicators related to mental health disorders and medications, which could inform the development of future safety improvement initiatives and interventional studies. CI - © 2020 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. FAU - Khawagi, Wael Y AU - Khawagi WY AUID- ORCID: 0000-0002-9489-1697 AD - Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. AD - Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Kingdom of Saudi Arabia. FAU - Steinke, Douglas T AU - Steinke DT AUID- ORCID: 0000-0001-8917-2674 AD - Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Nguyen, Joanne AU - Nguyen J AD - Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. AD - Pharmacy Department, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. FAU - Pontefract, Sarah AU - Pontefract S AUID- ORCID: 0000-0002-0344-4075 AD - School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK. FAU - Keers, Richard N AU - Keers RN AUID- ORCID: 0000-0001-7854-8154 AD - Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. AD - Pharmacy Department, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. LA - eng PT - Journal Article DEP - 20200617 PL - England TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 SB - IM MH - Delphi Technique MH - Humans MH - Inappropriate Prescribing MH - *Mental Disorders/drug therapy/epidemiology MH - *Mental Health MH - Polypharmacy MH - Potentially Inappropriate Medication List OTO - NOTNLM OT - consensus OT - medication safety OT - prescribing indicators OT - quality indicators EDAT- 2020/05/22 06:00 MHDA- 2021/07/29 06:00 CRDT- 2020/05/22 06:00 PHST- 2019/12/17 00:00 [received] PHST- 2020/05/07 00:00 [revised] PHST- 2020/05/12 00:00 [accepted] PHST- 2020/05/22 06:00 [pubmed] PHST- 2021/07/29 06:00 [medline] PHST- 2020/05/22 06:00 [entrez] AID - 10.1111/bcp.14391 [doi] PST - ppublish SO - Br J Clin Pharmacol. 2021 Jan;87(1):189-209. doi: 10.1111/bcp.14391. Epub 2020 Jun 17. PMID- 29360418 OWN - NLM STAT- MEDLINE DCOM- 20190422 LR - 20250103 IS - 1556-3669 (Electronic) IS - 1530-5627 (Print) IS - 1530-5627 (Linking) VI - 24 IP - 8 DP - 2018 Aug TI - A Virtual Environment-Based Training System for a Blind Wheelchair User Through Use of Three-Dimensional Audio Supported by Electroencephalography. PG - 614-620 LID - 10.1089/tmj.2017.0201 [doi] AB - People with disabilities encounter many difficulties, especially when a diagnosis of more than one dysfunction is made, as is the case for visually impaired wheelchair users. In fact, this scenario generates a degree of incapacity in terms of the performance of basic activities on the part of the wheelchair user. The treatment of disabled patients is performed in an individualized manner according to their particular clinical aspects. People with visual and motor disabilities are restricted in independent navigation. In this navigation scenario, there is a requirement for interaction that justifies the use of virtual reality (VR). In addition, locomotion needs to be under natural control to be successfully incorporated. Based on such a condition, electroencephalography (EEG) has shown great advances in the area of health by employing spontaneous brain signals. This research demonstrates, through an experiment, the use of a wheelchair adapted to have the support of VR and EEG for training of locomotion and individualized interaction of wheelchair users with visual impairment. The objective was to provide efficient interactions, thus allowing the social inclusion of patients who are considered otherwise incapacitated. This project was based on the following criteria: natural control, feedback, stimuli, and safety. A multilayer computer rehabilitation system was developed that incorporated natural interaction supported by EEG, which activated the movements in the virtual environment and real wheelchair through adequately performed experiments. This research consisted of elaborating a suitable approach for blind wheelchair user patients. The results demonstrated that the use of VR with EEG signals has the potential for improving the quality of life and independence of blind wheelchair users. FAU - Silva de Souza, Everton AU - Silva de Souza E AD - Virtual Reality, Universidade Federal de Uberlândia , Uberlândia, Brazil . FAU - Cardoso, Alexandre AU - Cardoso A AD - Virtual Reality, Universidade Federal de Uberlândia , Uberlândia, Brazil . FAU - Lamounier, Edgard AU - Lamounier E AD - Virtual Reality, Universidade Federal de Uberlândia , Uberlândia, Brazil . LA - eng PT - Journal Article DEP - 20180123 PL - United States TA - Telemed J E Health JT - Telemedicine journal and e-health : the official journal of the American Telemedicine Association JID - 100959949 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - *Audiovisual Aids MH - Persons with Disabilities/*education/*rehabilitation MH - Electroencephalography/methods MH - Female MH - Humans MH - Male MH - Middle Aged MH - Patient Education as Topic/*methods MH - Robotics/methods MH - Telemedicine/*methods MH - *Virtual Reality MH - *Wheelchairs PMC - PMC6088258 OTO - NOTNLM OT - e-health OT - extreme environments OT - rehabilitation OT - sensor technology OT - telemedicine COIS- No competing financial interests exist. EDAT- 2018/01/24 06:00 MHDA- 2019/04/23 06:00 PMCR- 2018/08/01 CRDT- 2018/01/24 06:00 PHST- 2018/01/24 06:00 [pubmed] PHST- 2019/04/23 06:00 [medline] PHST- 2018/01/24 06:00 [entrez] PHST- 2018/08/01 00:00 [pmc-release] AID - 10.1089/tmj.2017.0201 [pii] AID - 10.1089/tmj.2017.0201 [doi] PST - ppublish SO - Telemed J E Health. 2018 Aug;24(8):614-620. doi: 10.1089/tmj.2017.0201. Epub 2018 Jan 23. PMID- 39416946 OWN - NLM STAT- MEDLINE DCOM- 20241017 LR - 20241018 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 12 DP - 2024 TI - Exploring organizational aspects that promote health-related preventive behavior: using the example of work-related SARS-CoV-2 infection control measures in Germany, August 2020 to November 2021. PG - 1388996 LID - 10.3389/fpubh.2024.1388996 [doi] LID - 1388996 AB - INTRODUCTION: During the communicable coronavirus disease (COVID-19) pandemic, organizational infection control measures (oICMs) were introduced in the workplace. The employees' positive attitudes and active participation are relevant for full effectiveness regarding disease prevention. Therefore, we explore changes in employees' attitudes toward oICM at work from August-October 2020 (T0) over January 2021 (T1) to October-November 2021 (T2). We further investigate the role an organization can play in supporting health-related preventive behavior. METHODS: We considered repeated cross-sectional and longitudinal panel survey data from 5,554 employees of a global supplier of technology and services in Germany. A total of 16 items constitute the attitude scores toward oICM (5-point Likert scale). Via mixed-effect model, aspects associated with employees' attitudes toward oICM were explored. Via 'extreme-group' approach, we compared the 20% of participants with the largest changes into less favorable to the 20% with the largest changes into more favorable attitudes toward oICM over time. RESULTS: The overall positive attitudes toward work-related oICM were more favorable at T1 (mean ± SD: 4.2 ± 0.6, median (IQR): 4.3 (0.8), n = 2,515) compared to T0 (4.1 ± 0.6, 4.1 (0.8), n = 2,417) but less favorable at T2 (3.9 ± 0.7, 4.0 (0.9), n = 2,062). Among others, feeling well-informed about possible work-related risks of infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), perceived psychosocial demands through work environment aspects, and perceived management's commitment to safety and health were associated with long-term positive attitudes toward oICM. Individuals developing more favorable attitudes toward oICM reported feeling well-informed about possible work-related SARS-CoV-2 infection risks and improved COVID-19-specific resilience over time. Individuals developing less favorable attitudes toward oICM reported decreased perceptions of COVID-19-associated risks. CONCLUSION: oICMs in the workplace were perceived appropriate even after COVID-19 vaccines were widely available although the perceived affective risks about SARS-CoV-2 decreased. Taken together, our findings highlight how organizations can support employees in adopting health-related preventive behavior. Among others, we found that feeling well-informed about possible work-related health risks was positively associated with long-term favorable attitudes toward work-related oICM. We expect that the results contribute to the development of interventions to prepare and adapt to future global public health concerns. CI - Copyright © 2024 Soeder, Wagner, Neunhöffer, Martus, Papenfuss, Wittich, Schwille-Kiuntke, Rind and Rieger. FAU - Soeder, Jana AU - Soeder J AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Wagner, Anke AU - Wagner A AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Neunhöffer, Anna T AU - Neunhöffer AT AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Martus, Peter AU - Martus P AD - Institute for Clinical Epidemiology and Applied Biometry, University Hospital Tübingen, Tübingen, Germany. FAU - Papenfuss, Falko AU - Papenfuss F AD - Medical Services, Robert Bosch GmbH, Stuttgart, Germany. FAU - Wittich, Andrea AU - Wittich A AD - Occupational Psychologist and Psychotherapist, Tübingen, Germany. FAU - Schwille-Kiuntke, Juliane AU - Schwille-Kiuntke J AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Rind, Esther AU - Rind E AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. FAU - Rieger, Monika A AU - Rieger MA AD - Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Tübingen, Germany. LA - eng PT - Journal Article DEP - 20241002 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *COVID-19/prevention & control MH - Germany MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - *Workplace/psychology MH - Longitudinal Studies MH - Middle Aged MH - *SARS-CoV-2 MH - *Infection Control MH - Surveys and Questionnaires MH - Health Behavior PMC - PMC11480029 OTO - NOTNLM OT - COVID-19 OT - SARS-CoV-2 OT - attitude OT - health promotion OT - occupational safety and health OT - safety culture OT - working condition OT - workplace COIS- JS-K’s sole permanent employment relationship is with the Regierungspräsidium Tübingen/public health department Hechingen, Zollernalbkreis. She declares no conflict of interest. FP has been involved as consultant, expert, and co-author and is employed at the Robert Bosch GmbH. FP has been primarily involved in developing the study idea and the design and content of the online employee survey. The participating company had no role in the analysis of data, the interpretation of results, or the decision to publish the results. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/17 10:44 MHDA- 2024/10/17 10:45 PMCR- 2024/10/02 CRDT- 2024/10/17 05:01 PHST- 2024/02/20 00:00 [received] PHST- 2024/09/02 00:00 [accepted] PHST- 2024/10/17 10:45 [medline] PHST- 2024/10/17 10:44 [pubmed] PHST- 2024/10/17 05:01 [entrez] PHST- 2024/10/02 00:00 [pmc-release] AID - 10.3389/fpubh.2024.1388996 [doi] PST - epublish SO - Front Public Health. 2024 Oct 2;12:1388996. doi: 10.3389/fpubh.2024.1388996. eCollection 2024. PMID- 12775314 OWN - NLM STAT- MEDLINE DCOM- 20030710 LR - 20191107 IS - 0954-6634 (Print) IS - 0954-6634 (Linking) VI - 14 IP - 2 DP - 2003 Jun TI - Eumovate (clobetasone butyrate 0.05%) cream: a review of clinical efficacy and safety. PG - 71-85 AB - Topical steroid creams and ointments have been available as over-the-counter (OTC) medications for the self treatment of acute dermatitis and other steroid responsive skin disorders for more than ten years. Despite earlier fears, widespread availability and use of these creams is not associated with clinically significant adverse effects. In dermatological practice, hydrocortisone 1% remains the mainstay of treatment for facial eczema, but it is often not effective in eczema affecting other body areas. Eumovate(TM) (clobetasone butyrate 0.05%) cream has recently been made available as a pharmacy medication for the short-term management of acute eczema and allergic dermatitis by adults and children aged 10 or older, based on evidence derived from clinical trials involving over 3500 patients. This review summarises the key efficacy and safety data derived from 29 clinical trials and the post-licensing pharmacovigilance safety information, which supported the reclassification of this product for OTC use. These data show clobetasone butyrate 0.05% is more effective than 1.0% hydrocortisone in the treatment of eczema and more effective than flurandrenolone 0.0125% (p=0.01%) and a potent topical steroid hydrocortisone butyrate (p<0.05), in the treatment of psoriasis. A review of the effect of topical steroids on skin thickness concluded that, following short term application, there was no clinically significant difference between hydrocortisone 1.0% and clobetasone butyrate 0.05% in terms of potential for skin thinning. Similarly, even under extreme conditions, clobetasone butyrate 0.05% has negligible systemic absorption and has almost no effect on HPA axis function. FAU - Goustas, P AU - Goustas P AD - GlaxoSmithKline, Great West Road, Brentford, Middlesex TW8 9GS, UK. peter.c.goustas@gsk.com FAU - Cork, M J AU - Cork MJ FAU - Higson, D AU - Higson D LA - eng PT - Journal Article PT - Review PL - England TA - J Dermatolog Treat JT - The Journal of dermatological treatment JID - 8918133 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Nonprescription Drugs) RN - 0 (Ointments) RN - 8U0H6XI6EO (clobetasone butyrate) RN - ADN79D536H (Clobetasol) RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Acute Disease MH - Administration, Cutaneous MH - Administration, Topical MH - Adverse Drug Reaction Reporting Systems MH - Anti-Inflammatory Agents/administration & dosage/adverse effects/*therapeutic use MH - Clobetasol/administration & dosage/adverse effects/*analogs & derivatives/*therapeutic use MH - Dermatitis/*drug therapy/pathology MH - Humans MH - Hydrocortisone/administration & dosage/therapeutic use MH - Nonprescription Drugs MH - Ointments MH - Randomized Controlled Trials as Topic MH - Self Medication RF - 56 EDAT- 2003/05/31 05:00 MHDA- 2003/07/11 05:00 CRDT- 2003/05/31 05:00 PHST- 2003/05/31 05:00 [pubmed] PHST- 2003/07/11 05:00 [medline] PHST- 2003/05/31 05:00 [entrez] AID - YX3R3C29VBDCT966 [pii] AID - 10.1080/09546630310004180 [doi] PST - ppublish SO - J Dermatolog Treat. 2003 Jun;14(2):71-85. doi: 10.1080/09546630310004180. PMID- 31421044 OWN - NLM STAT- MEDLINE DCOM- 20200302 LR - 20210213 IS - 1619-3997 (Electronic) IS - 0300-5577 (Linking) VI - 47 IP - 8 DP - 2019 Oct 25 TI - Protocols for early discharging of premature infants: an empirical assessment on safety and savings. PG - 885-893 LID - 10.1515/jpm-2018-0420 [doi] AB - Background Preterm newborns may be discharged when clinical conditions are stable. Several criteria for early discharge have been proposed in the literature. This study carried out the first quantitative comparison of their impact in terms of hospitalization savings, safety and costs. Methods This study was based on the clinical histories of 213 premature infants born in the Neonatal Intensive Care Unit of Padova University Hospital between 2013 and 2014. Seventeen early discharge criteria were drawn from the literature and retrospectively applied to these data, and computation of hospitalization savings, safety and costs implied by each criterion was carried out. Results Among the criteria considered, average gains ranged from 1.1 to 10.3 hospital days and between 0.3 and 1.1 fewer infections per discharged infant. Criteria that led to saving more hospital days had higher cost-effectiveness in terms of crisis and infection, and they spared infants from more infections. However, episodes of apnea and bradycardia were detected after the potential early discharge date for all criteria, with a mean number of episodes numbering between 0.3 and 1.4. Conclusion The results highlight a clear trade-off between days saved and health risks for infants, with potential consequences for health care costs. FAU - Daicampi, Chiara AU - Daicampi C AD - Department of Women's and Children's Health, University of Padova, Padova, Italy. FAU - Comoretto, Rosanna I AU - Comoretto RI AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. FAU - Soriani, Nicola AU - Soriani N AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. FAU - Lolli, Elisabetta AU - Lolli E AD - Department of Women's and Children's Health, University of Padova, Padova, Italy. FAU - Boschetto, Stefania AU - Boschetto S AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. FAU - Cecchin, Micol AU - Cecchin M AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. FAU - Marinetto, Anna AU - Marinetto A AD - Department of Women's and Children's Health, University of Padova, Padova, Italy. FAU - Pagano, Eva AU - Pagano E AD - Unit of Cancer Epidemiology, University of Torino, CERMS and CPO-Piemonte, Torino, Italy. FAU - Perissinotto, Egle AU - Perissinotto E AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. FAU - Baraldi, Eugenio AU - Baraldi E AD - Department of Women's and Children's Health, University of Padova, Padova, Italy. FAU - Gregori, Dario AU - Gregori D AD - Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan 18, 35121 Padova, Italy. LA - eng PT - Journal Article PL - Germany TA - J Perinat Med JT - Journal of perinatal medicine JID - 0361031 SB - IM MH - Apnea/epidemiology MH - Bradycardia/epidemiology MH - *Clinical Protocols MH - Female MH - Humans MH - *Infant, Extremely Premature MH - Infant, Newborn MH - Infections/epidemiology MH - Intensive Care Units, Neonatal/*economics MH - Italy/epidemiology MH - Male MH - Patient Discharge/*economics MH - Retrospective Studies OTO - NOTNLM OT - cost-effectiveness OT - criteria for discharge OT - early discharge infants OT - safety EDAT- 2019/08/20 06:00 MHDA- 2020/03/03 06:00 CRDT- 2019/08/18 06:00 PHST- 2018/12/14 00:00 [received] PHST- 2019/07/26 00:00 [accepted] PHST- 2019/08/20 06:00 [pubmed] PHST- 2020/03/03 06:00 [medline] PHST- 2019/08/18 06:00 [entrez] AID - jpm-2018-0420 [pii] AID - 10.1515/jpm-2018-0420 [doi] PST - ppublish SO - J Perinat Med. 2019 Oct 25;47(8):885-893. doi: 10.1515/jpm-2018-0420. PMID- 25627755 OWN - NLM STAT- MEDLINE DCOM- 20151027 LR - 20181113 IS - 1559-6834 (Electronic) IS - 0899-823X (Print) IS - 0899-823X (Linking) VI - 36 IP - 1 DP - 2015 Jan TI - Cost-benefit analysis from the hospital perspective of universal active screening followed by contact precautions for methicillin-resistant Staphylococcus aureus carriers. PG - 2-13 LID - 10.1017/ice.2014.1 [doi] AB - OBJECTIVE To explore the economic impact to a hospital of universal methicillin-resistant Staphylococcus aureus (MRSA) screening. METHODS We used a decision tree model to estimate the direct economic impact to an individual hospital of starting universal MRSA screening and contact precautions. Projected costs and benefits were based on literature-derived data. Our model examined outcomes of several strategies including non-nares MRSA screening and comparison of culture versus polymerase chain reaction-based screening. RESULTS Under baseline conditions, the costs of universal MRSA screening and contact precautions outweighed the projected benefits generated by preventing MRSA-related infections, resulting in economic costs of $104,000 per 10,000 admissions (95% CI, $83,000-$126,000). Cost-savings occurred only when the model used estimates at the extremes of our key parameters. Non-nares screening and polymerase chain reaction-based testing, both of which identified more MRSA-colonized persons, resulted in more MRSA infections averted but increased economic costs of the screening program. CONCLUSIONS We found that universal MRSA screening, although providing potential benefit in preventing MRSA infection, is relatively costly and may be economically burdensome for a hospital. Policy makers should consider the economic burden of MRSA screening and contact precautions in relation to other interventions when choosing programs to improve patient safety and outcomes. FAU - McKinnell, James A AU - McKinnell JA AD - 1Infectious Disease Clinical Outcomes Research Unit,Division of Infectious Disease,Los Angeles Biomedical Research Institute,Harbor-UCLA Medical Center,Torrance,California. FAU - Bartsch, Sarah M AU - Bartsch SM AD - 3Public Health Computational and Operations Research Group (PHICOR),Johns Hopkins Bloomberg School of Public Health,Baltimore,Maryland. FAU - Lee, Bruce Y AU - Lee BY AD - 3Public Health Computational and Operations Research Group (PHICOR),Johns Hopkins Bloomberg School of Public Health,Baltimore,Maryland. FAU - Huang, Susan S AU - Huang SS AD - 5Division of Infectious Diseases and Health Policy Research Institute,University of California,Irvine School of Medicine,Irvine,California. FAU - Miller, Loren G AU - Miller LG AD - 1Infectious Disease Clinical Outcomes Research Unit,Division of Infectious Disease,Los Angeles Biomedical Research Institute,Harbor-UCLA Medical Center,Torrance,California. LA - eng GR - KL2 TR000122/TR/NCATS NIH HHS/United States GR - RC4 AI092327/AI/NIAID NIH HHS/United States GR - KL2TR000122/TR/NCATS NIH HHS/United States GR - RC4AI092327/AI/NIAID NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Infect Control Hosp Epidemiol JT - Infection control and hospital epidemiology JID - 8804099 SB - IM CIN - Infect Control Hosp Epidemiol. 2015 Jan;36(1):14-6. doi: 10.1017/ice.2014.25. PMID: 25627756 CIN - Infect Control Hosp Epidemiol. 2015 Jul;36(7):856-7. doi: 10.1017/ice.2015.111. PMID: 26081998 CIN - Infect Control Hosp Epidemiol. 2015 Jul;36(7):857-8. doi: 10.1017/ice.2015.112. PMID: 26081999 MH - Carrier State/*diagnosis MH - Colony Count, Microbial/economics MH - Cost-Benefit Analysis MH - Cross Infection/prevention & control MH - *Hospital Costs MH - Humans MH - Infection Control/*economics MH - Mass Screening/*economics MH - *Methicillin-Resistant Staphylococcus aureus MH - Nose/microbiology MH - Oropharynx/microbiology MH - Polymerase Chain Reaction/economics MH - Staphylococcal Infections/*diagnosis/prevention & control PMC - PMC4500653 MID - NIHMS694007 EDAT- 2015/01/30 06:00 MHDA- 2015/10/28 06:00 PMCR- 2016/01/01 CRDT- 2015/01/29 06:00 PHST- 2015/01/29 06:00 [entrez] PHST- 2015/01/30 06:00 [pubmed] PHST- 2015/10/28 06:00 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - S0899823X14000014 [pii] AID - 10.1017/ice.2014.1 [doi] PST - ppublish SO - Infect Control Hosp Epidemiol. 2015 Jan;36(1):2-13. doi: 10.1017/ice.2014.1. PMID- 33519729 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210202 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 11 DP - 2020 TI - A Thermostable, Modified Cathelicidin-Derived Peptide With Enhanced Membrane-Active Activity Against Salmonella enterica serovar Typhimurium. PG - 592220 LID - 10.3389/fmicb.2020.592220 [doi] LID - 592220 AB - Foodborne illness caused by consumption of food contaminated with Salmonella is one of the most common causes of diarrheal disease and affects millions of people worldwide. The rising emergence and spread of antimicrobial resistance, especially in some serotypes of Salmonella, has raised a great awareness of public health issues worldwide. To ensure safety of the food processing chain, the development of new food preservatives must be expedited. Recently, thermal- and pH-stable antimicrobial peptides have received much attention for use in food production, and represent safe alternatives to chemical preservatives. A 12-mer cathelicidin-derived, α-helical cationic peptide, P7, displayed rapid killing activity, against strains of drug-resistant foodborne Salmonella enterica serovar Typhimurium and its monophasic variant (S. enterica serovar 4,5,12:i:-) and had minimal toxicity against mouse fibroblast cells. P7 tended to form helical structure in the membrane-mimic environments as evaluated by circular dichroism (CD) spectroscopy. The action mode of P7 at the membrane-level was affirmed by the results of flow cytometry, and confocal, scanning and transmission electron microscopy. P7 killed bacteria through binding to bacterial membranes, penetration and the subsequent accumulation in S. enterica serovar Typhimurium cytoplasm. This induced membrane depolarization, permeabilization, and sequential leakage of intracellular substances and cell death. Except for sensitivity to proteolytic digestive enzymes, P7 maintained its inhibitory activity against S. enterica serovar Typhimurium in the presence of different conditions [various salts, extreme pHs and heat (even at 100°C)]. Moreover, the peptide is unlikely to induce bacterial resistance in vitro. Taken together, this study demonstrated that the membrane-permeabilizing P7 peptide has much potential as a new antimicrobial agent for use in food processing and preservation. CI - Copyright © 2021 Klubthawee and Aunpad. FAU - Klubthawee, Natthaporn AU - Klubthawee N AD - Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand. FAU - Aunpad, Ratchaneewan AU - Aunpad R AD - Graduate Program in Biomedical Sciences, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand. LA - eng PT - Journal Article DEP - 20210113 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC7838546 OTO - NOTNLM OT - drug-resistant Salmonella OT - food preservative OT - induction of resistance OT - membrane-active mechanism OT - thermostable peptide COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/02/02 06:00 MHDA- 2021/02/02 06:01 PMCR- 2021/01/13 CRDT- 2021/02/01 05:55 PHST- 2020/08/06 00:00 [received] PHST- 2020/12/16 00:00 [accepted] PHST- 2021/02/01 05:55 [entrez] PHST- 2021/02/02 06:00 [pubmed] PHST- 2021/02/02 06:01 [medline] PHST- 2021/01/13 00:00 [pmc-release] AID - 10.3389/fmicb.2020.592220 [doi] PST - epublish SO - Front Microbiol. 2021 Jan 13;11:592220. doi: 10.3389/fmicb.2020.592220. eCollection 2020. PMID- 35174527 OWN - NLM STAT- MEDLINE DCOM- 20220615 LR - 20220731 IS - 1365-2125 (Electronic) IS - 0306-5251 (Print) IS - 0306-5251 (Linking) VI - 88 IP - 7 DP - 2022 Jul TI - An e-Delphi study to obtain expert consensus on the level of risk associated with preventable e-prescribing events. PG - 3351-3359 LID - 10.1111/bcp.15284 [doi] AB - AIMS: We aim to seek expert opinion and gain consensus on the risks associated with a range of prescribing scenarios, preventable using e-prescribing systems, to inform the development of a simulation tool to evaluate the risk and safety of e-prescribing systems (ePRaSE). METHODS: We conducted a two-round e-Delphi survey where expert participants were asked to score pre-designed prescribing scenarios using a five-point Likert scale to ascertain the likelihood of occurrence of the prescribing event, likelihood of occurrence of harm and the severity of the harm. RESULTS: Twenty-four experts consented to participate with 15 pand 13 participants completing rounds 1 and 2, respectively. Experts agreed on the level of risk associated with 136 out of 178 clinical scenarios with 131 scenarios categorised as high or extreme risk. CONCLUSION: We identified 131 extreme or high-risk prescribing scenarios that may be prevented using e-prescribing clinical decision support. The prescribing scenarios represent a variety of categories, with drug-disease contraindications being the most frequent, representing 37 (27%) scenarios, and antimicrobial agents being the most common drug class, representing 28 (21%) of the scenarios. Our e-Delphi study has achieved expert consensus on the risk associated with a range of clinical scenarios with most of the scenarios categorised as extreme or high risk. These prescribing scenarios represent the breadth of preventable prescribing error categories involving both basic and advanced clinical decision support. We will use the findings of this study to inform the development of the e-prescribing risk and safety evaluation tool. CI - © 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. FAU - Heed, Jude AU - Heed J AUID- ORCID: 0000-0001-6046-6011 AD - School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK. FAU - Klein, Stephanie AU - Klein S AD - The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. FAU - Slee, Ann AU - Slee A AD - NHS X, UK. FAU - Watson, Neil AU - Watson N AD - The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. FAU - Husband, Andy AU - Husband A AD - School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK. FAU - Slight, Sarah Patricia AU - Slight SP AD - School of Pharmacy, Newcastle upon Tyne, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220308 PL - England TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 SB - IM MH - Consensus MH - *Decision Support Systems, Clinical MH - Delphi Technique MH - *Electronic Prescribing MH - Humans PMC - PMC9313843 OTO - NOTNLM OT - medication errors OT - patient safety OT - prescribing OT - quality use of medicines COIS- The authors report there are no conflicts of interest to declare. EDAT- 2022/02/18 06:00 MHDA- 2022/06/16 06:00 PMCR- 2022/03/08 CRDT- 2022/02/17 05:40 PHST- 2021/12/10 00:00 [revised] PHST- 2021/09/30 00:00 [received] PHST- 2022/01/26 00:00 [accepted] PHST- 2022/02/18 06:00 [pubmed] PHST- 2022/06/16 06:00 [medline] PHST- 2022/02/17 05:40 [entrez] PHST- 2022/03/08 00:00 [pmc-release] AID - BCP15284 [pii] AID - 10.1111/bcp.15284 [doi] PST - ppublish SO - Br J Clin Pharmacol. 2022 Jul;88(7):3351-3359. doi: 10.1111/bcp.15284. Epub 2022 Mar 8. PMID- 9825425 OWN - NLM STAT- MEDLINE DCOM- 19990322 LR - 20231213 IS - 0964-4563 (Print) IS - 1468-3318 (Electronic) IS - 0964-4563 (Linking) VI - 7 IP - 3 DP - 1998 Autumn TI - Green tobacco sickness. PG - 294-8 AB - OBJECTIVE: To describe the health impact of harvesting tobacco and to suggest prevention and risk reduction strategies to avoid contracting green tobacco sickness (GTS). DATA SOURCES: A literature search of Medline, Toxline, and Toxline65 with the terms "green", "tobacco", and "sickness" covering the years 1966-1998. STUDY SELECTION: All studies, reviews, and commentaries that provided information on the health effects of harvesting green tobacco and disease prevention strategies. DATA SYNTHESIS: GTS occurs when tobacco workers hand-harvest, cut, or load tobacco plants, usually in the early morning or after a rainfall when tobacco plants are covered with moisture. GTS occurs through skin exposure to dissolved nicotine from tobacco leaves. Symptoms of GTS include weakness, headache, nausea, vomiting, dizziness, abdominal cramps, breathing difficulty, abnormal temperature, pallor, diarrhoea, chills, fluctuations in blood pressure or heart rate, and increased perspiration and salivation. The onset of the illness is three to 17 hours after exposure and the duration of illness is one to three days. Initial treatment includes cessation of work, change of clothing, showering, fluid intake, and rest. In more extreme cases, intravenous rehydration, anti-emetics, and dimenhydrinate are administered. Protective, water-resistant clothing; chemical-resistant gloves, boots, and socks; working in dry conditions; and dimenhydrinate can reduce the likelihood of contracting GTS. CONCLUSIONS: It is important to provide education to tobacco workers and employers about GTS. An international public awareness campaign about GTS timed to coincide with the tobacco harvest, along with enforced worker safety regulations, should be undertaken to protect the health of individuals working in tobacco production. FAU - McBride, J S AU - McBride JS AD - Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1063, USA. FAU - Altman, D G AU - Altman DG FAU - Klein, M AU - Klein M FAU - White, W AU - White W LA - eng GR - R01 CA67838-02/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - England TA - Tob Control JT - Tobacco control JID - 9209612 RN - 6M3C89ZY6R (Nicotine) SB - IM MH - Adolescent MH - Adult MH - *Employment MH - Female MH - *Health Status MH - Humans MH - Male MH - Nicotine/*metabolism MH - Occupational Exposure/*adverse effects MH - *Plants, Toxic MH - Nicotiana/*adverse effects PMC - PMC1763894 EDAT- 1998/11/24 00:00 MHDA- 1998/11/24 00:01 PMCR- 2001/09/01 CRDT- 1998/11/24 00:00 PHST- 1998/11/24 00:00 [pubmed] PHST- 1998/11/24 00:01 [medline] PHST- 1998/11/24 00:00 [entrez] PHST- 2001/09/01 00:00 [pmc-release] AID - 10.1136/tc.7.3.294 [doi] PST - ppublish SO - Tob Control. 1998 Autumn;7(3):294-8. doi: 10.1136/tc.7.3.294. PMID- 33963967 OWN - NLM STAT- MEDLINE DCOM- 20211125 LR - 20220218 IS - 1556-2891 (Electronic) IS - 1547-769X (Print) IS - 1547-769X (Linking) VI - 17 IP - 3 DP - 2021 Sep TI - Post-mortem persistence of SARS-CoV-2: a preliminary study. PG - 403-410 LID - 10.1007/s12024-021-00375-z [doi] AB - Since the beginning of March 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been the cause of millions of deaths worldwide. The need to better define the pathogenesis of coronavirus disease 19 (Covid-19) as well as to provide the correct statistical records concerning deaths related to this virus, inevitably involves the role of forensic pathology and routine autopsy practice. Currently, some data on macroscopic and microscopic features in autopsies performed in suspected Covid-19 cases are reported in the literature. The persistence of SARS-CoV-2 in cadavers has not yet been elucidated and only a few reports have emphasized the importance of evaluating the Virus RNA in post-mortem tissues. In this preliminary study, we observed that SARS-CoV-2 survives in multiple cadaver tissues many days after death despite some extreme conditions of post-mortem body preservation. The results of this on-going analysis could help improve the safety of working practices for pathologists as well as understanding the possible interaction between microbiological agents and the cadaver tissue's supravital reactions. CI - © 2021. The Author(s). FAU - Sablone, Sara AU - Sablone S AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Solarino, Biagio AU - Solarino B AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. biagio.solarino@uniba.it. FAU - Ferorelli, Davide AU - Ferorelli D AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Benevento, Marcello AU - Benevento M AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Chironna, Maria AU - Chironna M AD - Section of Hygiene, Department of Biomedical Sciences and Human Oncology, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Loconsole, Daniela AU - Loconsole D AD - Section of Hygiene, Department of Biomedical Sciences and Human Oncology, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Sallustio, Anna AU - Sallustio A AD - Section of Hygiene, Department of Biomedical Sciences and Human Oncology, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Dell'Erba, Alessandro AU - Dell'Erba A AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. FAU - Introna, Francesco AU - Introna F AD - Section of Legal Medicine, Department of Interdisciplinary Medicine, Bari Policlinico Hospital, University of Bari, 70124, Bari, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210508 PL - United States TA - Forensic Sci Med Pathol JT - Forensic science, medicine, and pathology JID - 101236111 SB - IM MH - Autopsy MH - *COVID-19 MH - Cadaver MH - Humans MH - Pandemics MH - *SARS-CoV-2 PMC - PMC8105695 OTO - NOTNLM OT - COVID-19 autopsy OT - Cadaver tissue samples OT - Post-mortem interval OT - SARS-CoV-2 OT - Viral RNA EDAT- 2021/05/09 06:00 MHDA- 2021/11/26 06:00 PMCR- 2021/05/08 CRDT- 2021/05/08 12:10 PHST- 2021/04/04 00:00 [accepted] PHST- 2021/05/09 06:00 [pubmed] PHST- 2021/11/26 06:00 [medline] PHST- 2021/05/08 12:10 [entrez] PHST- 2021/05/08 00:00 [pmc-release] AID - 10.1007/s12024-021-00375-z [pii] AID - 375 [pii] AID - 10.1007/s12024-021-00375-z [doi] PST - ppublish SO - Forensic Sci Med Pathol. 2021 Sep;17(3):403-410. doi: 10.1007/s12024-021-00375-z. Epub 2021 May 8. PMID- 734332 OWN - NLM STAT- MEDLINE DCOM- 19790324 LR - 20061115 IS - 0300-8592 (Print) IS - 0300-8592 (Linking) VI - 31 IP - 12 DP - 1978 Dec TI - [Sonographic renal diagnosis in paediatrics (author's transl)]. PG - 652-7 AB - Sonography is a method without risk but of high diagnostic value. Hence, it is extremely well suited for paediatric examination. In our opinion, this method should rank first among all other examination methods when clarifying inflammatory conditions of kidneys and of the efferent urinary tract, whereas in all other problems sonography continues to rank second behind the urogram. Both examinations together, which account for a diagnostic safety of more than 95%, are employed to decide whether and to what extent other and more invasive and complicated measures will have to be taken. FAU - Schneekloth, G AU - Schneekloth G FAU - Albers, G AU - Albers G FAU - Frank, T AU - Frank T LA - ger PT - English Abstract PT - Journal Article TT - Sonographische Nierendiagnostik in der Pädiatrie. PL - Germany TA - Rontgenblatter JT - Rontgen-Blatter; Zeitschrift fur Rontgen-Technik und medizinisch-wissenschaftliche Photographie JID - 0413560 SB - IM MH - Abdominal Neoplasms/diagnosis MH - Adolescent MH - Age Factors MH - Child MH - Diagnosis, Differential MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Kidney Diseases/*diagnosis MH - Kidney Neoplasms/diagnosis MH - Male MH - Methods MH - Nephritis/diagnosis MH - *Ultrasonography MH - Urinary Tract Infections/diagnosis EDAT- 1978/12/01 00:00 MHDA- 1978/12/01 00:01 CRDT- 1978/12/01 00:00 PHST- 1978/12/01 00:00 [pubmed] PHST- 1978/12/01 00:01 [medline] PHST- 1978/12/01 00:00 [entrez] PST - ppublish SO - Rontgenblatter. 1978 Dec;31(12):652-7. PMID- 10603555 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 2376-9130 (Electronic) IS - 1080-3548 (Linking) VI - 1 IP - 3 DP - 1995 Jan TI - Physiological Method of Evaluating Protective Clothing for Work in a Cold Environment. PG - 235-243 LID - 10.1080/10803548.1995.11076321 [doi] AB - The purpose of this study was to determine the usefulness of physiological studies in the evaluation of protective clothing for work in a cold environment. The study included the examination of the dynamics of changes in chosen physiological parameters (core and skin temperatures, heart rate, pulmonary minute ventilation) as well as physical ones (the temperature and relative humidity under the clothes) during work in protective clothing with unknown thermal insulation. The experiment was conducted in extreme environmental conditions (-10 and -15°C) at a work load defined by the clothing manufacturer as moderate. Results show that thermal equilibrium was achieved and maintained throughout the investigated work time (60 min) and that the protective clothing ensures safety on the time scale of a regular 8-hour work day. It was also shown that the dynamics of thermal stress physiological parameters can be used to determine the maximum duration of exposure for cold protective clothing with unknown thermal insulation. FAU - Marszałek, Anna AU - Marszałek A AD - a Central Institute for Labour Protection , Poland. FAU - Sołtyński, Krzysztof AU - Sołtyński K AD - a Central Institute for Labour Protection , Poland. FAU - Sawicka, Alicja AU - Sawicka A AD - a Central Institute for Labour Protection , Poland. LA - eng PT - Journal Article PL - England TA - Int J Occup Saf Ergon JT - International journal of occupational safety and ergonomics : JOSE JID - 9507598 OTO - NOTNLM OT - cold environment OT - physiology OT - protective clothing EDAT- 1995/01/01 00:00 MHDA- 1999/12/22 00:00 CRDT- 1995/01/01 00:00 PHST- 1995/01/01 00:00 [pubmed] PHST- 1999/12/22 00:00 [medline] PHST- 1995/01/01 00:00 [entrez] AID - 10.1080/10803548.1995.11076321 [doi] PST - ppublish SO - Int J Occup Saf Ergon. 1995 Jan;1(3):235-243. doi: 10.1080/10803548.1995.11076321. PMID- 34372392 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 15 DP - 2021 Jul 29 TI - Preview Control with Dynamic Constraints for Autonomous Vehicles. LID - 10.3390/s21155155 [doi] LID - 5155 AB - In this paper, a preview theory-based steering control approach considering vehicle dynamic constraints is presented. The constrained variables are predicted by an error states system and utilized to adjust the control law once the established dynamic constraints are violated. The simulated annealing optimization algorithm for preview length is conducted to improve the adaptability of the controller to varying velocities and road adhesion coefficients. The theoretical stability of a closed-loop system is guaranteed using Lyapunov theory, and further analysis of the system response in time domain and frequency domain is discussed. The results of simulations implemented on Carsim-Simulink demonstrate the favorable performance of the proposed control in tracking accuracy and system stability under extreme conditions. FAU - Li, Rui AU - Li R AD - School of Automation, Chongqing University, Chongqing 400044, China. FAU - Ouyang, Qi AU - Ouyang Q AD - School of Automation, Chongqing University, Chongqing 400044, China. FAU - Cui, Yue AU - Cui Y AD - School of Automation, Chongqing University, Chongqing 400044, China. FAU - Jin, Yang AU - Jin Y AD - School of Automation, Chongqing University, Chongqing 400044, China. LA - eng GR - NVHSKL-202115/State Key Laboratory of Vehicle NVH and Safety Technology Open Fund/ PT - Journal Article DEP - 20210729 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC8347934 OTO - NOTNLM OT - autonomous vehicles OT - dynamic constraints OT - preview control COIS- The authors declare no conflict of interest. EDAT- 2021/08/11 06:00 MHDA- 2021/08/11 06:01 PMCR- 2021/07/29 CRDT- 2021/08/10 01:04 PHST- 2021/06/08 00:00 [received] PHST- 2021/07/16 00:00 [revised] PHST- 2021/07/20 00:00 [accepted] PHST- 2021/08/10 01:04 [entrez] PHST- 2021/08/11 06:00 [pubmed] PHST- 2021/08/11 06:01 [medline] PHST- 2021/07/29 00:00 [pmc-release] AID - s21155155 [pii] AID - sensors-21-05155 [pii] AID - 10.3390/s21155155 [doi] PST - epublish SO - Sensors (Basel). 2021 Jul 29;21(15):5155. doi: 10.3390/s21155155. PMID- 23411757 OWN - NLM STAT- MEDLINE DCOM- 20131217 LR - 20190608 IS - 1880-8026 (Electronic) IS - 0019-8366 (Linking) VI - 51 IP - 1 DP - 2013 TI - Mapping occupational heat exposure and effects in South-East Asia: ongoing time trends 1980-2011 and future estimates to 2050. PG - 56-67 AB - A feature of climate impacts on occupational health and safety are physiological limits to carrying out physical work at high heat exposure. Heat stress reduces a workers work capacity, leading to lower hourly labour productivity and economic output. We used existing weather station data and climate modeling grid cell data to describe heat conditions (calculated as Wet Bulb Globe Temperature, WBGT) in South-East Asia. During the hottest month in this region (March) afternoon WBGT levels are already high enough to cause major loss of hourly work capacity and by 2050 the situation will be extreme for many outdoor jobs. FAU - Kjellstrom, Tord AU - Kjellstrom T AD - Centre for Global Health Research, Umea University, Sweden. kjellstromt@yahoo.com FAU - Lemke, Bruno AU - Lemke B FAU - Otto, Matthias AU - Otto M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Japan TA - Ind Health JT - Industrial health JID - 2985065R SB - IM MH - Asia, Southeastern/epidemiology MH - *Climate Change MH - Efficiency MH - Forecasting MH - Heat Stress Disorders/*epidemiology MH - Humans MH - Occupational Exposure/*adverse effects MH - Seasons EDAT- 2013/02/16 06:00 MHDA- 2013/12/18 06:00 CRDT- 2013/02/16 06:00 PHST- 2013/02/16 06:00 [entrez] PHST- 2013/02/16 06:00 [pubmed] PHST- 2013/12/18 06:00 [medline] AID - DN/JST.JSTAGE/indhealth/2012-0174 [pii] AID - 10.2486/indhealth.2012-0174 [doi] PST - ppublish SO - Ind Health. 2013;51(1):56-67. doi: 10.2486/indhealth.2012-0174. PMID- 38327140 OWN - NLM STAT- MEDLINE DCOM- 20240410 LR - 20240503 IS - 1541-3772 (Electronic) IS - 1048-2911 (Linking) VI - 34 IP - 1 DP - 2024 May TI - The "Creuseurs" ("Diggers"), at the Center of the World's Push for EVs, are in Peril: Part One-The Precarious Reality of Artisanal Mines. PG - 52-53 LID - 10.1177/10482911241228881 [doi] AB - Electronics Watch travelled to Kolwezi in the province of Lualaba, in the south of the Democratic Republic of Congo. Two worlds live side by side here, without ever crossing paths. On the one hand, the world of industrial mines, with their huge machines. On the other, the tens of thousands of "diggers" in small-scale artisanal mines, armed with a simple crowbar to exploit a mineral vein, in extremely dangerous conditions. The DRC alone has 80% of the world's cobalt stocks needed to manufacture batteries to serve the demand for electric vehicles, and no less than 30% of this stock is mined in an artisanal way. One to two million Congolese people depend on this production directly or indirectly, while world demand is booming. FAU - Warneck, Fabrice AU - Warneck F AD - Electronics Watch, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20240207 PL - United States TA - New Solut JT - New solutions : a journal of environmental and occupational health policy : NS JID - 9100937 RN - Congolese people SB - IM CIN - New Solut. 2024 May;34(1):54-55. doi: 10.1177/10482911241228882. PMID: 38321781 MH - Humans MH - *Mining MH - *Central African People OTO - NOTNLM OT - cobalt mining industry OT - government regulation OT - occupational safety OT - supply chain COIS- Declaration of Conflicting InterestsThe author declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article. EDAT- 2024/02/08 06:43 MHDA- 2024/04/10 06:43 CRDT- 2024/02/08 02:23 PHST- 2024/04/10 06:43 [medline] PHST- 2024/02/08 06:43 [pubmed] PHST- 2024/02/08 02:23 [entrez] AID - 10.1177/10482911241228881 [doi] PST - ppublish SO - New Solut. 2024 May;34(1):52-53. doi: 10.1177/10482911241228881. Epub 2024 Feb 7. PMID- 12173182 OWN - NLM STAT- MEDLINE DCOM- 20021210 LR - 20191106 IS - 1542-8117 (Print) IS - 1542-8117 (Linking) VI - 63 IP - 3 DP - 2002 May-Jun TI - Evaluation of passive card monitors for hydrogen sulfide for use in kraft pulp mill workplace atmospheres. PG - 317-25 AB - Six different brands of passive card monitors representing three different types of card monitor were evaluated for their effectiveness in testing for hydrogen sulfide in workplace atmospheres. The cards were evaluated both in the laboratory and in a kraft pulp mill according to a protocol that closely follows that recommended by the National Institute for Occupational Safety and Health and other researchers for passive samplers. The performances of the Envirometrics Air-Chem Technologies and the Gilian ChemAir quantitative cards, the Gilian ChromAir and VICI Metronics Colortec semiquantitative cards, and the American Gas & Chemical Co. Leak-Tec and Gilian SafeAir indicator cards were evaluated. The detection limits of the cards were determined, and the cards were exposed to a range of hydrogen sulfide concentrations (1, 5, 10, 20 ppm), face velocities (0, 50 ft/min), and temperature/humidity combinations (95 degrees F/90% humidity, 77 degrees F/50% humidity, 40 degrees F/20% humidity). The cards' responses to short-term and variable concentration exposures as well as to the potential interferents methyl mercaptan, dimethyl sulfide, dimethyl disulfide, sulfur dioxide, and carbon monoxide were assessed. Each of the cards tested demonstrated a usefulness for the detection and/or quantification of hydrogen sulfide at concentrations and under conditions relevant to kraft pulp mill workplace atmospheres. Which card is best depends on the application, sampling conditions, and level of confidence necessary in the results. The Gilian ChemAir quantitative card performed well under most conditions with acceptable accuracy (13% lab, 26% field), and no response to potential interferents or to changes in face velocity, temperature, and humidity. The Envirometrics ACT quantitative cards did not perform as well, with an accuracy level of only 46% in the lab. They also seemed to be more affected by changes in face velocity, temperature, and humidity. Both semiquantitative cards (Gillian ChromAir, VICI Metronics Colortec) provided reasonable approximations of hydrogen sulfide levels in the range of the hydrogen sulfide occupational exposure levels although the VICI card had a much lower detection limit. Neither performed well at high temperature and humidity. The response of VICI card was more affected by changes in face velocity, whereas the Gilian ChromAir showed some response to reduced sulfur gas interferents. Both indicator cards (Leak-Tec, Gilian SafeAir) performed well, responding to 20 ppm hydrogen sulfide within 1 min and to 5 ppm within 5 min. Neither was significantly affected by extremes of temperature and humidity. FAU - Saunders, Fran AU - Saunders F AD - National Council for Air and Stream Improvement, Inc., P.O. Box 141020, Gainesville, FL 32614-1020, USA. FAU - Larson, Leon AU - Larson L FAU - Tatum, Vickie AU - Tatum V LA - eng PT - Journal Article PL - United States TA - AIHA J (Fairfax, Va) JT - AIHA journal : a journal for the science of occupational and environmental health and safety JID - 101146781 RN - 0 (Air Pollutants) RN - YY9FVM7NSN (Hydrogen Sulfide) SB - IM MH - Air Movements MH - Air Pollutants/*analysis MH - Environmental Monitoring/*instrumentation MH - Humans MH - Humidity MH - Hydrogen Sulfide/*analysis MH - Industry MH - *Occupational Exposure MH - Paper MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Temperature MH - *Workplace EDAT- 2002/08/14 10:00 MHDA- 2002/12/11 04:00 CRDT- 2002/08/14 10:00 PHST- 2002/08/14 10:00 [pubmed] PHST- 2002/12/11 04:00 [medline] PHST- 2002/08/14 10:00 [entrez] AID - 10.1080/15428110208984720 [doi] PST - ppublish SO - AIHA J (Fairfax, Va). 2002 May-Jun;63(3):317-25. doi: 10.1080/15428110208984720. PMID- 36281704 OWN - NLM STAT- MEDLINE DCOM- 20230428 LR - 20230508 IS - 1600-0447 (Electronic) IS - 0001-690X (Linking) VI - 147 IP - 5 DP - 2023 May TI - Challenges in diagnosis and management of delirium in Lewy body disease. PG - 475-480 LID - 10.1111/acps.13514 [doi] AB - BACKGROUND: Delirium is an acute onset and fluctuating impairment of cognition, attention and arousal, often precipitated by acute illness. Lewy body disease (LBD) is an umbrella term for a range of clinical conditions, including Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). People living with LBD seem to be more susceptible to delirium than those with other subtypes of dementia. AIM: To describe the challenges in clinical diagnosis and management of LBD. METHODS: A systematic review of published literature on diagnosis and management of delirium in LBD. RESULTS: Delirium is particularly challenging to diagnose in LBD as many of the clinical characteristics which define delirium such as inattention, fluctuating arousal, complex visual hallucinations and delusions, are also common to LBD. Distinguishing delirium from LBD can be very difficult clinically especially in the prodromal stages. Both under and over diagnosis of delirium, and under and over treatment of the symptoms have the potential to compromise the care and safety of people with a diagnosed or undiagnosed LBD. Clinicians are currently working with an extremely limited set of evidence-based management options for those with delirium in the context of a LBD diagnosis. For patients with LBD and their families this is an area of clinical practice that needs focused research. CI - © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd. FAU - Richardson, Sarah AU - Richardson S AD - AGE Research Group, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. FAU - Lawson, Rachael A AU - Lawson RA AD - Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. FAU - Price, Annabel AU - Price A AUID- ORCID: 0000-0002-5505-5231 AD - Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK. AD - Department of Psychological Medicine, Cambridgeshire and Peterborough Foundation NHS Trust, Cambridge, UK. FAU - Taylor, John-Paul AU - Taylor JP AD - Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK. LA - eng GR - DH_/Department of Health/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20221104 PL - United States TA - Acta Psychiatr Scand JT - Acta psychiatrica Scandinavica JID - 0370364 SB - IM MH - Humans MH - *Lewy Body Disease/therapy/drug therapy MH - *Dementia MH - *Parkinson Disease/complications/diagnosis MH - *Alzheimer Disease MH - Hallucinations MH - *Delirium/diagnosis/etiology/therapy OTO - NOTNLM OT - delirium OT - dementia OT - lewy EDAT- 2022/10/26 06:00 MHDA- 2023/04/28 06:42 CRDT- 2022/10/25 04:22 PHST- 2022/10/03 00:00 [revised] PHST- 2022/04/25 00:00 [received] PHST- 2022/10/20 00:00 [accepted] PHST- 2023/04/28 06:42 [medline] PHST- 2022/10/26 06:00 [pubmed] PHST- 2022/10/25 04:22 [entrez] AID - 10.1111/acps.13514 [doi] PST - ppublish SO - Acta Psychiatr Scand. 2023 May;147(5):475-480. doi: 10.1111/acps.13514. Epub 2022 Nov 4. PMID- 21229935 OWN - NLM STAT- MEDLINE DCOM- 20110224 LR - 20220409 IS - 0891-0162 (Print) IS - 0891-0162 (Linking) VI - 59 IP - 1 DP - 2011 Jan TI - Preventing heat-related illness among Hispanic farmworkers. PG - 23-32 LID - 10.3928/08910162-20101228-01 [doi] AB - Hispanic and Latino farmworkers are at risk for negative occupational health and safety outcomes due to issues such as their extreme work conditions, their reliance on employer beneficence, and cultural barriers. The purpose of this article is to explain the unique characteristics of heat-related illness in the Hispanic agricultural work force and to provide an overview of the problems of poor hydration and heat exposure in this population. Culturally appropriate preventive strategies are discussed because industrial-type solutions may not work in a crop production environment where language and beliefs may interfere with adaptation. CI - 2011, SLACK Incorporated. FAU - Culp, Kennith AU - Culp K AD - College of Nursing, University of Iowa, Iowa City, IA 52242, USA. ken-culp@uiowa.edu FAU - Tonelli, Shalome AU - Tonelli S FAU - Ramey, Sandra L AU - Ramey SL FAU - Donham, Kelley AU - Donham K FAU - Fuortes, Laurence AU - Fuortes L LA - eng PT - Journal Article PT - Review PL - United States TA - AAOHN J JT - AAOHN journal : official journal of the American Association of Occupational Health Nurses JID - 8608669 MH - Agricultural Workers' Diseases/*nursing/*prevention & control MH - Heat Exhaustion/*nursing/*prevention & control MH - *Hispanic or Latino MH - Humans MH - Occupational Health Nursing/*methods EDAT- 2011/01/15 06:00 MHDA- 2011/02/25 06:00 CRDT- 2011/01/15 06:00 PHST- 2010/03/30 00:00 [received] PHST- 2010/10/19 00:00 [accepted] PHST- 2011/01/15 06:00 [entrez] PHST- 2011/01/15 06:00 [pubmed] PHST- 2011/02/25 06:00 [medline] AID - 10.3928/08910162-20101228-01 [doi] PST - ppublish SO - AAOHN J. 2011 Jan;59(1):23-32. doi: 10.3928/08910162-20101228-01. PMID- 8419589 OWN - NLM STAT- MEDLINE DCOM- 19930205 LR - 20190814 IS - 0278-2391 (Print) IS - 0278-2391 (Linking) VI - 51 IP - 1 Suppl 1 DP - 1993 Jan TI - Current trends in implant reconstruction. PG - 7-19 AB - Significant advances have occurred in preprosthetic surgery in the past decade. Patients whose problems range from the loss of a single tooth to extreme conditions involving acquired or congenital defects now have options for reconstruction previously not possible. Optimal care most often requires a team approach with careful planning and execution. Ongoing basic research and strict clinical documentation involving current and future areas of treatment will provide an even greater degree of safety and effectiveness for our patients. FAU - Higuchi, K W AU - Higuchi KW AD - Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans 70119. FAU - Block, M S AU - Block MS LA - eng PT - Journal Article PT - Review PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 RN - 0 (Dental Implants) SB - IM MH - Bone Transplantation MH - Dental Implantation, Endosseous/*trends MH - Dental Implants MH - Dental Prosthesis Design MH - Humans MH - Jaw, Edentulous/rehabilitation MH - Maxillary Sinus/surgery MH - Oral Surgical Procedures, Preprosthetic/*methods MH - Patient Care Planning RF - 52 EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 0278-2391(93)90005-X [pii] AID - 10.1016/0278-2391(93)90005-x [doi] PST - ppublish SO - J Oral Maxillofac Surg. 1993 Jan;51(1 Suppl 1):7-19. doi: 10.1016/0278-2391(93)90005-x. PMID- 38875453 OWN - NLM STAT- MEDLINE DCOM- 20240614 LR - 20240619 IS - 2242-3982 (Electronic) IS - 1239-9736 (Print) IS - 1239-9736 (Linking) VI - 83 IP - 1 DP - 2024 Dec TI - Repeated freezing to very low temperatures does not impact the amount ejected from EpiPen® and Jext® adrenaline autoinjectors. PG - 2367273 LID - 10.1080/22423982.2024.2367273 [doi] LID - 2367273 AB - It has previously been shown that EpiPen® autoinjectors are likely to activate normally following up to five excursions to -25°C but data about the post-freezing performance of other brands of adrenaline autoinjectors has not previously been published. Additionally, conditions experienced by polar medics may be substantially colder than this and the performance of adrenaline autoinjectors following more extreme freeze-thaw cycles remains uncharacterised. Investigators in Antarctica and the United Kingdom performed laboratory testing on two brands of adrenaline autoinjector, EpiPen® and Jext® (12 devices of each type). A single freeze-thaw cycle involved freezing the device to -80°C then allowing it to come to room temperature. Devices were exposed to 0, 1, 5 or 15 freeze-thaw cycles. The mass of liquid ejected from each device, when activated, was then measured. No significant differences in the mass of the liquid ejected was found between the test groups. Multiple freeze-thaw cycles to -80°C are unlikely to significantly impact the amount of adrenaline solution expelled from EpiPen® and EpiPen® autoinjectors. This preliminary finding encourages further work investigating the safety and effectiveness of adrenaline autoinjectors after exposure to very low temperatures. This information would be valuable for future polar medics planning and delivering medical provision in extreme environments. FAU - Wood, Felix N R AU - Wood FNR AUID- ORCID: 0000-0002-5706-852X AD - Academic Department of Military Emergency Medicine, Royal Centre for Defence, Medicine, Birmingham, UK. AD - British Antarctic Survey Medical Unit, Plymouth, UK. FAU - Hartley, Rosemary AU - Hartley R AD - British Antarctic Survey Medical Unit, Plymouth, UK. FAU - Boys, Rebecca AU - Boys R AD - British Antarctic Survey Medical Unit, Plymouth, UK. FAU - Parham, Timothy AU - Parham T AD - British Antarctic Survey Medical Unit, Plymouth, UK. FAU - Lowe, Jonathon AU - Lowe J AD - Academic Department of Military Emergency Medicine, Royal Centre for Defence, Medicine, Birmingham, UK. AD - British Antarctic Survey Medical Unit, Plymouth, UK. FAU - Warner, Matthew AU - Warner M AD - British Antarctic Survey Medical Unit, Plymouth, UK. LA - eng PT - Journal Article DEP - 20240614 PL - United States TA - Int J Circumpolar Health JT - International journal of circumpolar health JID - 9713056 RN - YKH834O4BH (Epinephrine) SB - IM MH - *Epinephrine/administration & dosage MH - *Freezing MH - Humans MH - *Cold Temperature MH - Injections, Intramuscular/instrumentation PMC - PMC11182065 OTO - NOTNLM OT - Emergency OT - adrenaline OT - anaphylaxis OT - expedition medicine OT - prehospital COIS- No potential conflict of interest was reported by the author(s). EDAT- 2024/06/14 18:42 MHDA- 2024/06/14 18:43 PMCR- 2024/06/14 CRDT- 2024/06/14 14:42 PHST- 2024/06/14 18:43 [medline] PHST- 2024/06/14 18:42 [pubmed] PHST- 2024/06/14 14:42 [entrez] PHST- 2024/06/14 00:00 [pmc-release] AID - 2367273 [pii] AID - 10.1080/22423982.2024.2367273 [doi] PST - ppublish SO - Int J Circumpolar Health. 2024 Dec;83(1):2367273. doi: 10.1080/22423982.2024.2367273. Epub 2024 Jun 14. PMID- 39511917 OWN - NLM STAT- MEDLINE DCOM- 20241108 LR - 20241108 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 18 DP - 2024 Nov 8 TI - Urgent Warning: Evidence-Based Concerns Regarding Mass Gathering Events During Arbaeen in Hazardous Weather Conditions. PG - e258 LID - 10.1017/dmp.2024.173 [doi] AB - The Arbaeen ceremony is the largest annual mass gathering in the world, attracting millions of Muslim pilgrims each year. However, the event takes place during the summer in Iraq, coinciding with extreme heat and dust storms. Climate change hazards, such as heat waves and dust storms, can have destructive effects on human health, leading to increased mortality and the spread of various diseases. This manuscript recommends measures to stakeholders in emergency or public health management to develop a preventive plan for the Arbaeen ceremony. These measures include improving planning and risk assessment, enhancing capacities, reducing vulnerabilities, increasing knowledge and awareness among pilgrims, developing communication and support systems, ensuring compliance with safety protocols, and regularly assessing evacuation routes. Implementing these measures will contribute to ensuring the safety and well-being of participants during the Arbaeen ceremony in the years ahead. FAU - Aghababaeian, Hamidreza AU - Aghababaeian H AUID- ORCID: 0000-0003-3339-5507 AD - Department of Health in Emergencies and Disasters, Dezful University of Medical Sciences, Dezful, Iran. AD - Center for Climate Change and Health Research (CCCHR), Dezful University of Medical Sciences, Dezful, Iran. AD - Universal Scientific Education and Research Network (USERN), Dezful University of Medical Sciences, Dezful, Iran. FAU - Etedali, Hooman AU - Etedali H AD - Center for Climate Change and Health Research (CCCHR), Dezful University of Medical Sciences, Dezful, Iran. AD - Student Research Committee, Dezful University of Medical Sciences, Dezful, Iran. LA - eng PT - Journal Article DEP - 20241108 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Humans MH - Iraq MH - *Weather MH - Climate Change/statistics & numerical data MH - Islam/psychology MH - Disaster Planning/methods MH - Mass Behavior MH - Crowding OTO - NOTNLM OT - climate change OT - disasters OT - emergencies OT - health OT - mass gathering EDAT- 2024/11/13 13:51 MHDA- 2024/11/14 03:54 CRDT- 2024/11/08 02:03 PHST- 2024/11/14 03:54 [medline] PHST- 2024/11/13 13:51 [pubmed] PHST- 2024/11/08 02:03 [entrez] AID - S1935789324001733 [pii] AID - 10.1017/dmp.2024.173 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2024 Nov 8;18:e258. doi: 10.1017/dmp.2024.173. PMID- 1489358 OWN - NLM STAT- MEDLINE DCOM- 19930223 LR - 20071115 IS - 0067-5016 (Print) IS - 0067-5016 (Linking) VI - 50 DP - 1992 TI - [Bolus death and drowning--expression of central nervous system dysregulation?]. PG - 7-11 AB - According to the author's own investigations and to findings reported in the literature, almost all bolus deaths and highly numerous accidental deaths by drowning occur to adults and adolescents under the impact of alcohol. An attempt was made to elucidate the mechanism by which alcohol actually play its role in bolus or drowning death. These two causes of death have in common complete or partial obstruction of respiratory tract. Yet, safety against that life-threatening condition were devised by evolution very early in phylogenesis (respiratory block, cough reflex, circulatory centralisation). They are reflex-triggered for immediate effect and take that effect through the vegetative nervous system. These findings have been secured by animal experiments. However, on account of considerable interference of alcohol with vegetative activity, via action on transmitter metabolism (transmitter synthesis, storage, release, rebonding and bonding by means of products of alcohol metabolism), symptoms of extreme vagotomia may develop, such as bradycardia with circulatory centralisation and apnoea of alcohol-related irreversibility, finally resulting in cardiac arrest. The "reflex-related" process of bolus death has often been described, with reference being regulatory made to individuals staying in water and drowning without any self-rescue attempt. FAU - Patzelt, D AU - Patzelt D AD - Institut für Rechtsmedizin, Ernst-Moritz-Arndt-Universität Greifswald. LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Bolus- und Ertrinkungstod--Ausdruck einer zentralnervösen Regulationsstörung? PL - Austria TA - Beitr Gerichtl Med JT - Beitrage zur gerichtlichen Medizin JID - 0400646 SB - IM MH - Airway Obstruction/*physiopathology MH - Alcohol Drinking/adverse effects/*physiopathology MH - Animals MH - Autonomic Nervous System/drug effects/*physiopathology MH - Drowning/*physiopathology MH - Heart Arrest/*physiopathology MH - Hemodynamics/drug effects/physiology MH - Humans MH - Respiration/drug effects/physiology RF - 24 EDAT- 1992/01/01 00:00 MHDA- 1992/01/01 00:01 CRDT- 1992/01/01 00:00 PHST- 1992/01/01 00:00 [pubmed] PHST- 1992/01/01 00:01 [medline] PHST- 1992/01/01 00:00 [entrez] PST - ppublish SO - Beitr Gerichtl Med. 1992;50:7-11. PMID- 35063054 OWN - NLM STAT- MEDLINE DCOM- 20220125 LR - 20220125 IS - 2375-6322 (Electronic) IS - 2375-6314 (Linking) VI - 93 IP - 1 DP - 2022 Jan 1 TI - Optimization of Exercise Countermeasures to Spaceflight Using Blood Flow Restriction. PG - 32-45 LID - 10.3357/AMHP.5855.2021 [doi] AB - INTRODUCTION: During spaceflight missions, astronauts work in an extreme environment with several hazards to physical health and performance. Exposure to microgravity results in remarkable deconditioning of several physiological systems, leading to impaired physical condition and human performance, posing a major risk to overall mission success and crew safety. Physical exercise is the cornerstone of strategies to mitigate physical deconditioning during spaceflight. Decades of research have enabled development of more optimal exercise strategies and equipment onboard the International Space Station. However, the effects of microgravity cannot be completely ameliorated with current exercise countermeasures. Moreover, future spaceflight missions deeper into space require a new generation of spacecraft, which will place yet more constraints on the use of exercise by limiting the amount, size, and weight of exercise equipment and the time available for exercise. Space agencies are exploring ways to optimize exercise countermeasures for spaceflight, specifically exercise strategies that are more efficient, require less equipment, and are less time-consuming. Blood flow restriction exercise is a low intensity exercise strategy that requires minimal equipment and can elicit positive training benefits across multiple physiological systems. This method of exercise training has potential as a strategy to optimize exercise countermeasures during spaceflight and reconditioning in terrestrial and partial gravity environments. The possible applications of blood flow restriction exercise during spaceflight are discussed herein.Hughes L, Hackney KJ, Patterson SD. Optimization of exercise countermeasures to spaceflight using blood flow restriction. Aerosp Med Hum Perform. 2021; 93(1):32-45. FAU - Hughes, Luke AU - Hughes L FAU - Hackney, Kyle J AU - Hackney KJ FAU - Patterson, Stephen D AU - Patterson SD LA - eng PT - Journal Article PL - United States TA - Aerosp Med Hum Perform JT - Aerospace medicine and human performance JID - 101654770 SB - IM MH - Astronauts MH - Blood Flow Restriction Therapy MH - Exercise MH - Humans MH - *Space Flight MH - *Weightlessness EDAT- 2022/01/23 06:00 MHDA- 2022/01/27 06:00 CRDT- 2022/01/22 05:32 PHST- 2022/01/22 05:32 [entrez] PHST- 2022/01/23 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] AID - 10.3357/AMHP.5855.2021 [doi] PST - ppublish SO - Aerosp Med Hum Perform. 2022 Jan 1;93(1):32-45. doi: 10.3357/AMHP.5855.2021. PMID- 36244055 OWN - NLM STAT- MEDLINE DCOM- 20230124 LR - 20230224 IS - 1865-8652 (Electronic) IS - 0741-238X (Print) IS - 0741-238X (Linking) VI - 40 IP - 1 DP - 2023 Jan TI - Risk and Management of Bleeding Complications with Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Venous Thromboembolism: a Narrative Review. PG - 41-66 LID - 10.1007/s12325-022-02333-9 [doi] AB - Atrial fibrillation (AF) and venous thromboembolism (VTE) are highly prevalent conditions with a significant healthcare burden, and represent the main indications for anticoagulation. Direct oral anticoagulants (DOACs) are the first choice treatment of AF/VTE, and have become the most prescribed class of anticoagulants globally, overtaking vitamin K antagonists (VKAs). Compared to VKAs, DOACs have a similar or better efficacy/safety profile, with reduced risk of intracerebral hemorrhage (ICH), while the risk of major bleeding and other bleeding harms may vary depending on the type of DOAC. We have critically reviewed available evidence from randomized controlled trials and observational studies regarding the risk of bleeding complications of DOACs compared to VKAs in patients with AF and VTE. Special patient populations (e.g., elderly, extreme body weights, chronic kidney disease) have specifically been addressed. Management of bleeding complications and possible resumption of anticoagulation, in particular after ICH and gastrointestinal bleeding, are also discussed. Finally, some suggestions are provided to choose the optimal DOAC to minimize adverse events according to individual patient characteristics and bleeding risk. CI - © 2022. The Author(s). FAU - Ballestri, Stefano AU - Ballestri S AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. s.ballestri@ausl.mo.it. FAU - Romagnoli, Elisa AU - Romagnoli E AD - Internal Medicine and Critical Care Unit, Azienda Ospedaliero-Universitaria, Modena, Italy. FAU - Arioli, Dimitriy AU - Arioli D AD - Internal Medicine and Critical Care Unit, Azienda Ospedaliero-Universitaria, Modena, Italy. FAU - Coluccio, Valeria AU - Coluccio V AD - Hematology Unit, Azienda Ospedaliero-Universitaria, Modena, Italy. FAU - Marrazzo, Alessandra AU - Marrazzo A AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. FAU - Athanasiou, Afroditi AU - Athanasiou A AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. FAU - Di Girolamo, Maria AU - Di Girolamo M AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. FAU - Cappi, Cinzia AU - Cappi C AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. FAU - Marietta, Marco AU - Marietta M AD - Hematology Unit, Azienda Ospedaliero-Universitaria, Modena, Italy. FAU - Capitelli, Mariano AU - Capitelli M AD - Internal Medicine Unit, Hospital of Pavullo-Department of Internal Medicine, Azienda USL, 41126, Pavullo, Modena, Italy. LA - eng PT - Journal Article PT - Review DEP - 20221016 PL - United States TA - Adv Ther JT - Advances in therapy JID - 8611864 RN - 0 (Anticoagulants) RN - 9NDF7JZ4M3 (Rivaroxaban) RN - I0VM4M70GC (Dabigatran) MH - Humans MH - Aged MH - *Atrial Fibrillation/complications/drug therapy MH - *Venous Thromboembolism/drug therapy MH - Anticoagulants/adverse effects MH - Cerebral Hemorrhage MH - Gastrointestinal Hemorrhage/chemically induced/drug therapy MH - Administration, Oral MH - Rivaroxaban/therapeutic use MH - *Stroke/complications/drug therapy MH - Dabigatran/adverse effects PMC - PMC9569921 OTO - NOTNLM OT - Anticoagulation reversal OT - Apixaban OT - Dabigatran OT - Edoxaban OT - Hemorrhage OT - Non-vitamin K antagonist oral anticoagulants OT - Rivaroxaban OT - Stroke OT - Thrombosis and embolism OT - Warfarin EDAT- 2022/10/17 06:00 MHDA- 2023/01/25 06:00 PMCR- 2022/10/16 CRDT- 2022/10/16 14:02 PHST- 2022/08/18 00:00 [received] PHST- 2022/09/21 00:00 [accepted] PHST- 2022/10/17 06:00 [pubmed] PHST- 2023/01/25 06:00 [medline] PHST- 2022/10/16 14:02 [entrez] PHST- 2022/10/16 00:00 [pmc-release] AID - 10.1007/s12325-022-02333-9 [pii] AID - 2333 [pii] AID - 10.1007/s12325-022-02333-9 [doi] PST - ppublish SO - Adv Ther. 2023 Jan;40(1):41-66. doi: 10.1007/s12325-022-02333-9. Epub 2022 Oct 16. PMID- 29179123 OWN - NLM STAT- MEDLINE DCOM- 20180808 LR - 20181202 IS - 1879-2448 (Electronic) IS - 0043-1354 (Linking) VI - 129 DP - 2018 Feb 1 TI - Spatial and temporal variability of bacterial indicators and pathogens in six California reservoirs during extreme drought. PG - 436-446 LID - S0043-1354(17)30954-5 [pii] LID - 10.1016/j.watres.2017.11.038 [doi] AB - California has one of the largest systems of surface water reservoirs in the world, providing irrigation water to California's agriculturally productive Central Valley. Irrigation water is recognized as a vehicle for the microbial contamination of raw produce and must be monitored according to new federal regulation. The purpose of this study was to further understanding of the variability of fecal indicator bacteria (Escherichia coli and fecal coliforms) and pathogens (E. coli O157:H7 (O157), non-O157 Shiga toxin-producing E. coli (STEC) and Salmonella) along both horizontal and vertical profiles within California reservoirs. Monthly sampling was conducted in six reservoirs located in the foothills of the Western Sierra Nevada during the summer irrigation season and extreme drought conditions of 2014 (n = 257). Concentrations of fecal indicator bacteria were highly variable between reservoirs (p < 0.05) and along the horizontal profile (p < 0.001) from upstream to downstream, with higher concentrations typically found outside of the reservoirs than within. Though many of the reservoirs were thermally stratified, bacterial concentrations were not associated with water temperature (p > 0.05) or any one particular depth strata (p < 0.05). However, prevalence of Salmonella and STEC (16/70 and 9/70 respectively) was higher in the deep strata than in mid or surface layers. We found no statistical association between samples collected downstream of reservoirs and those from the reservoirs themselves. Continued monitoring and modeling of both bacterial indicators and enteric pathogens are critical to our ability to estimate the risk of surface irrigation water supplies and make appropriate management decisions. CI - Copyright © 2017 Elsevier Ltd. All rights reserved. FAU - Partyka, Melissa L AU - Partyka ML AD - Western Center for Food Safety, School of Veterinary Medicine, University of California, Davis, USA. Electronic address: mlpartyka@ucdavis.edu. FAU - Bond, Ronald F AU - Bond RF AD - Western Center for Food Safety, School of Veterinary Medicine, University of California, Davis, USA. FAU - Chase, Jennifer A AU - Chase JA AD - Western Center for Food Safety, School of Veterinary Medicine, University of California, Davis, USA. FAU - Atwill, Edward R AU - Atwill ER AD - Western Center for Food Safety, School of Veterinary Medicine, University of California, Davis, USA. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20171116 PL - England TA - Water Res JT - Water research JID - 0105072 SB - IM MH - *Agricultural Irrigation MH - Agriculture MH - California MH - Droughts MH - Escherichia coli O157/isolation & purification MH - Feces/microbiology MH - Salmonella/isolation & purification MH - *Water Microbiology MH - *Water Quality MH - *Water Supply OTO - NOTNLM OT - Bacteria OT - Food safety OT - Irrigation water OT - Reservoir OT - Thermal stratification OT - Water quality EDAT- 2017/11/28 06:00 MHDA- 2018/08/09 06:00 CRDT- 2017/11/28 06:00 PHST- 2017/06/14 00:00 [received] PHST- 2017/10/10 00:00 [revised] PHST- 2017/11/15 00:00 [accepted] PHST- 2017/11/28 06:00 [pubmed] PHST- 2018/08/09 06:00 [medline] PHST- 2017/11/28 06:00 [entrez] AID - S0043-1354(17)30954-5 [pii] AID - 10.1016/j.watres.2017.11.038 [doi] PST - ppublish SO - Water Res. 2018 Feb 1;129:436-446. doi: 10.1016/j.watres.2017.11.038. Epub 2017 Nov 16. PMID- 19665900 OWN - NLM STAT- MEDLINE DCOM- 20100927 LR - 20100517 IS - 1878-4119 (Electronic) IS - 1010-5182 (Linking) VI - 38 IP - 4 DP - 2010 Jun TI - Thermochemotherapy of lower lip squamous cell carcinoma without metastases: an experience of 31 cases. PG - 260-5 LID - 10.1016/j.jcms.2009.07.008 [doi] AB - INTRODUCTION: The aim of this study was to evaluate the efficacy, functional and aesthetic results, and safety of a novel treatment, thermochemotherapy, for lower lip squamous cell carcinoma (LLSCC) without metastases. PATIENTS AND METHODS: A combination of local hyperthermia delivered by a 915MHz microwave heating system and the chemotherapy of pingyangmycin (bleomycin A(5) hydrochloride) (PYM) and methotrexate (MTX), was administered to 31 patients of LLSCC twice per week for a period of 4.5-7.5 weeks. Patients with complete response (CR) have been followed up for a full five-year period, whereas partial response (PR) patients were excluded for further analysis. The local control of tumour, functional and cosmetic outcomes, recurrence, regional lymph node and distant metastases, and complications were assessed by clinical and imaging examination. RESULTS: Clinical CR was observed in twenty-nine (93.55%) patients and PR in two (6.45%), the total response rate was 100%, while the adverse effects were extremely minimal and tolerable in all 31 patients including 6 elderly patients with a compromised general condition. All 29 CR, including 8 extensive lesions, achieved excellent cosmetic and functional preservation. During the follow-up period, local relapse was seen in 1 case, 1 patient died, and the remainder obtained a complete remission. CONCLUSION: This clinical study suggests that thermochemotherapy may be a feasible treatment for primary LLSCC without cervical metastases, especially for patients with extensive lesions and a compromised general condition. CI - Copyright (c) 2009 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved. FAU - Liang, Xin-hua AU - Liang XH AD - Faculty, Department of Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. FAU - He, Yong-wen AU - He YW FAU - Tang, Ya-ling AU - Tang YL FAU - Wu, Jun-low AU - Wu JL FAU - Cao, Xuan-ping AU - Cao XP FAU - Xiao, Gui-zhou AU - Xiao GZ FAU - Mao, Zu-yi AU - Mao ZY LA - eng PT - Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090808 PL - Scotland TA - J Craniomaxillofac Surg JT - Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery JID - 8704309 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Carcinoma, Squamous Cell/*therapy MH - Chemotherapy, Adjuvant MH - Combined Modality Therapy MH - Disease-Free Survival MH - Female MH - *Fever MH - Follow-Up Studies MH - Humans MH - Lip Neoplasms/*therapy MH - Lymphatic Metastasis/prevention & control MH - Male MH - Middle Aged MH - *Neoadjuvant Therapy MH - Neoplasm Metastasis/*prevention & control MH - Recovery of Function MH - Treatment Outcome EDAT- 2009/08/12 09:00 MHDA- 2010/09/29 06:00 CRDT- 2009/08/12 09:00 PHST- 2008/12/08 00:00 [received] PHST- 2009/07/03 00:00 [revised] PHST- 2009/07/22 00:00 [accepted] PHST- 2009/08/12 09:00 [entrez] PHST- 2009/08/12 09:00 [pubmed] PHST- 2010/09/29 06:00 [medline] AID - S1010-5182(09)00140-1 [pii] AID - 10.1016/j.jcms.2009.07.008 [doi] PST - ppublish SO - J Craniomaxillofac Surg. 2010 Jun;38(4):260-5. doi: 10.1016/j.jcms.2009.07.008. Epub 2009 Aug 8. PMID- 39304167 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241116 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 954 DP - 2024 Dec 1 TI - Intensifying droughts render more Sahel drylands unsuitable for cultivation. PG - 176390 LID - S0048-9697(24)06546-X [pii] LID - 10.1016/j.scitotenv.2024.176390 [doi] AB - Two-fifth of the world's population will be confronted by dire land and water shortage for food production by 2050. Here we provide nuanced insights into the Sahel dryland dynamics and rationale behind its underperforming croplands amid climate extremes. We develop a gridded multi-criteria drought index for the growing season (June-October) and analyse its spatial and temporal degree of uniformity to designate the drought, climate and cultivable zones. Evidence is drawn from Sahelian Sudan, representing 1.03 million km(2) of the African Sahel, during 1940-2020. Results show that cultivation of marginal lands has persisted apace. The peak areas of these marginal lands explain ∼50 % of the variations in crop yield, considering the two staple crops, sorghum and millet. Furthermore, the low yields mismatch the steadily growing planted areas of these crops. Compared to wet conditions, droughts expand (shrink) the median size of hyper-arid (arid) area by 466 % (46 %), limiting farming opportunities for 3.5-35.8 % of the croplands. The northernmost borderline of the arid zone determines the rainfed suitability, but potentially cultivable arid areas require contingency risk-reduction plans. Conversely, semi-arid and dry sub-humid zones reveal areas endowed with uniform climate. Skillful climate forecasting should thus guide policymaking towards sustainable agriculture therein. The paper suggests paths towards more effective agricultural policy interventions. Agricultural production entails the Sahel drought being defined in terms of agricultural impacts instead of meteorological conditions. Land use planners and inhabitants must relieve the plight of misconceiving and overlooking the fact of intrinsic interannual rainfall variability. Determining what a dangerous drought is for the Sahel agriculture sector or system is crucial. Sahel farming systems should opt for highly flexible agricultural practices based on the above-identified cultivable areas. CI - Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Elagib, Nadir Ahmed AU - Elagib NA AD - Institute of Geography, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. Electronic address: nelagib@uni-koeln.de. FAU - Ali, Marwan M A AU - Ali MMA AD - Institute of Geography, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. FAU - Musa, Ammar Ahmed AU - Musa AA AD - Environment, Health and Safety Department, King Fahd University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia. LA - eng PT - Journal Article DEP - 20240918 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM OTO - NOTNLM OT - Climate zones OT - Drought OT - Dryland agriculture OT - Land management practices OT - Marginal lands OT - Sudan COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/09/21 16:19 MHDA- 2024/09/21 16:20 CRDT- 2024/09/20 19:33 PHST- 2024/08/01 00:00 [received] PHST- 2024/09/01 00:00 [revised] PHST- 2024/09/17 00:00 [accepted] PHST- 2024/09/21 16:20 [medline] PHST- 2024/09/21 16:19 [pubmed] PHST- 2024/09/20 19:33 [entrez] AID - S0048-9697(24)06546-X [pii] AID - 10.1016/j.scitotenv.2024.176390 [doi] PST - ppublish SO - Sci Total Environ. 2024 Dec 1;954:176390. doi: 10.1016/j.scitotenv.2024.176390. Epub 2024 Sep 18. PMID- 33028833 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201104 LR - 20211007 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 10 IP - 1 DP - 2020 Oct 7 TI - Projections of heat stress and associated work performance over India in response to global warming. PG - 16675 LID - 10.1038/s41598-020-73245-3 [doi] LID - 16675 AB - Summertime heat stress future projections from multi-model mean of 18 CMIP5 models show unprecedented increasing levels in the RCP 4.5 and RCP 8.5 emission scenarios over India. The estimated heat stress is found to have more impact on the coastal areas of India having exposure to more frequent days of extreme caution to danger category along with the increased probability of occurrence. The explicit amount of change in temperature, increase in the duration and intensity of warm days along with the modulation in large scale circulation in future are seemingly connected to the increasing levels of heat stress over India. A decline of 30 to 40% in the work performance is projected over India by the end of the century due to the elevated heat stress levels which pose great challenges to the country policy makers to design the safety mechanisms and to protect people working under continuous extreme hot weather conditions. FAU - Koteswara Rao, K AU - Koteswara Rao K AD - Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India. FAU - Lakshmi Kumar, T V AU - Lakshmi Kumar TV AD - Atmospheric Science Research Laboratory, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu, India. lkumarap@hotmail.com. FAU - Kulkarni, Ashwini AU - Kulkarni A AD - Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India. FAU - Ho, Chang-Hoi AU - Ho CH AD - School of Earth and Environmental Sciences, Seoul National University, Seoul, South Korea. FAU - Mahendranath, B AU - Mahendranath B AD - Department of Meteorology & Oceanography, Andhra University, Visakhapatnam, India. FAU - Desamsetti, Srinivas AU - Desamsetti S AD - National Centre for Medium Range Weather Forecasting, Ministry of Earth Sciences, Noida, India. FAU - Patwardhan, Savita AU - Patwardhan S AD - Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India. FAU - Dandi, Appala Ramu AU - Dandi AR AD - Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India. FAU - Barbosa, Humberto AU - Barbosa H AD - Laboratorio de Analise e Processamento de Imagens de Satelites, Universiadade Federal de Alogoas, UFAL, Maceió, Brazil. FAU - Sabade, Sudhir AU - Sabade S AD - Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, Pune, India. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201007 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC7542441 COIS- The authors declare no competing interests. EDAT- 2020/10/09 06:00 MHDA- 2020/10/09 06:01 PMCR- 2020/10/07 CRDT- 2020/10/08 05:28 PHST- 2019/07/08 00:00 [received] PHST- 2020/08/12 00:00 [accepted] PHST- 2020/10/08 05:28 [entrez] PHST- 2020/10/09 06:00 [pubmed] PHST- 2020/10/09 06:01 [medline] PHST- 2020/10/07 00:00 [pmc-release] AID - 10.1038/s41598-020-73245-3 [pii] AID - 73245 [pii] AID - 10.1038/s41598-020-73245-3 [doi] PST - epublish SO - Sci Rep. 2020 Oct 7;10(1):16675. doi: 10.1038/s41598-020-73245-3. PMID- 19190493 OWN - NLM STAT- MEDLINE DCOM- 20090831 LR - 20090603 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 3 IP - 2 DP - 2009 Jun TI - Adapting standards of care under extreme conditions. PG - 111-6 LID - 10.1097/DMP.0b013e31819b95dc [doi] AB - The filing of criminal charges against a group of clinicians in New Orleans for failure to meet expected standards of care following the hurricanes of 2005 made the growing concern among health professionals about care provided during extreme emergencies or disasters all too real. Questions about what may lead to censure, penalties from licensing boards, or lawsuits have come from nurses, physicians, and many other licensed health professionals. A panel convened by the American Nurses Association that included representatives of medical, public health, hospital, and government agencies considered the ethical, professional, and practical aspects of meeting standards of care in such circumstances. Clinicians are reminded that in emergencies, it is only the circumstances that change (perhaps radically); neither the individual's professional competency nor the basic professional standard of care is different. In making prioritized decisions under such circumstances, the individual's ethical framework is utilitarian, and there are 3 areas for action, even when some routine tasks are set aside: maintain worker and patient safety; maintain airway, breathing, and circulation; and establish or maintain infection control. Policy recommendations such as state legislation for the adoption of comprehensive immunity for volunteer health care workers, and the establishment of a medical review panel as arbitration board are also suggested. The resulting white paper summarizes the issues and provides guidance to individual professionals, institutions in which they work, and emergency planners. FAU - Gebbie, Kristine M AU - Gebbie KM AD - Hunter College, City University of New York, 425 E 25th St, Room 530W, New York, NY 10010, USA. kgebbie@hunter.cuny.edu FAU - Peterson, Cheryl A AU - Peterson CA FAU - Subbarao, Italo AU - Subbarao I FAU - White, Kathleen M AU - White KM LA - eng PT - Journal Article PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - American Nurses' Association MH - Clinical Competence/standards MH - Delivery of Health Care/*standards MH - Disaster Planning/*methods/*standards MH - *Emergencies MH - Guidelines as Topic MH - Health Personnel/*standards MH - Humans MH - Interprofessional Relations EDAT- 2009/02/05 09:00 MHDA- 2009/09/01 06:00 CRDT- 2009/02/05 09:00 PHST- 2009/02/05 09:00 [entrez] PHST- 2009/02/05 09:00 [pubmed] PHST- 2009/09/01 06:00 [medline] AID - 10.1097/DMP.0b013e31819b95dc [doi] PST - ppublish SO - Disaster Med Public Health Prep. 2009 Jun;3(2):111-6. doi: 10.1097/DMP.0b013e31819b95dc. PMID- 27093224 OWN - NLM STAT- MEDLINE DCOM- 20171116 LR - 20181202 IS - 1531-7013 (Electronic) IS - 1087-2418 (Linking) VI - 21 IP - 3 DP - 2016 Jun TI - Normothermic and subnormothermic ex-vivo liver perfusion in liver transplantation. PG - 315-21 LID - 10.1097/MOT.0000000000000305 [doi] AB - PURPOSE OF REVIEW: In the current era of extreme organ shortage, warm (subnormothermic and normothermic) ex-vivo liver perfusion has emerged as a novel strategy to recover marginal organs and increase the organ pool. Over the last decade, significant progress in the field has taken this technology from bench to bedside. This review will cover the most relevant contributions to the field in 2015. RECENT FINDINGS: Several groups made significant advances in warm ex-vivo liver perfusion for optimizing preservation of liver grafts. With transition to clinical use underway, significant interest has focused on exploring the safety and feasibility of the technique. Other areas of exploration included novel perfusates and rewarming strategies. This review will also summarize the most recent advances in the clinical setting. SUMMARY: Warm ex-vivo liver perfusion has established itself as a novel approach for the preservation of liver grafts for transplantation. Although the optimal perfusion conditions and techniques have not been established, the safety of this technique has been demonstrated in preclinical and clinical studies. Thus far, most investigation has focused on the rescue of marginal grafts. However, further development in the field has the potential to yield novel graft interventions and modification. FAU - Goldaracena, Nicolas AU - Goldaracena N AD - Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. FAU - Barbas, Andrew S AU - Barbas AS FAU - Selzner, Markus AU - Selzner M LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Organ Transplant JT - Current opinion in organ transplantation JID - 9717388 SB - IM MH - Extracorporeal Circulation MH - Humans MH - Liver/*pathology MH - Liver Transplantation/methods MH - Organ Preservation/methods MH - Perfusion/*methods EDAT- 2016/04/20 06:00 MHDA- 2017/11/29 06:00 CRDT- 2016/04/20 06:00 PHST- 2016/04/20 06:00 [entrez] PHST- 2016/04/20 06:00 [pubmed] PHST- 2017/11/29 06:00 [medline] AID - 10.1097/MOT.0000000000000305 [doi] PST - ppublish SO - Curr Opin Organ Transplant. 2016 Jun;21(3):315-21. doi: 10.1097/MOT.0000000000000305. PMID- 12611202 OWN - NLM STAT- MEDLINE DCOM- 20030326 LR - 20151119 IS - 0040-5957 (Print) IS - 0040-5957 (Linking) VI - 57 IP - 5 DP - 2002 Sep-Oct TI - [Benign prostatic hyperplasia: patients' perception of medical treatment and their expectations. Results of a french survey involving patients treated with finasteride]. PG - 473-83 AB - Benign prostatic hyperplasia (BPH) is increasingly common in medical practice, as a result of the inevitable aging of the population. The current therapeutic strategy includes three alternatives: watchful waiting, medical treatment and invasive therapy. Finasteride is one of the pharmacological options available. Many clinical studies have demonstrated its efficacy and good safety profile in patients with BPH. The survey we report provides new insights into what has to date been a purely therapeutic approach by taking into consideration patients' expectations and their perception of finasteride treatment. Results indicate that the main preoccupation for patients with BPH is that the pharmacological treatment will reduce the risk of major urological complications and the need for surgery (treatment characteristics considered as very or extremely important by 88 and 93% of patients, respectively). Decreasing symptoms and improving quality of life take second place after these primary concerns. Patient perception of finasteride is excellent. Nearly all patients are satisfied by the efficacy of the treatment, 89% of them reporting good to extremely good improvement of symptoms, the rapid onset of relief being particularly important. The efficacy of finasteride is not hindered by any tolerability issues and is further strengthened by its ease of use. Although this novel survey includes a number of biases, it nevertheless demonstrates that treatment of BPH with finasteride is well accepted by patients and satisfies their expectations. In addition, it provides a mass of general epidemiological data on patients with BPH, as well as on current medical practice regarding this condition. FAU - Teillac, P AU - Teillac P AD - Service d'Urologie, Hôpital Saint-Louis, Paris, France. LA - fre PT - English Abstract PT - Journal Article TT - Hypertrophie bénigne de la prostate: attentes des patients et perception du traitement. Résultats d'une enquête menée en France auprès de patients traités par finastéride. PL - France TA - Therapie JT - Therapie JID - 0420544 RN - 0 (Enzyme Inhibitors) RN - 57GNO57U7G (Finasteride) SB - IM MH - Aged MH - Data Collection MH - Enzyme Inhibitors/*therapeutic use MH - Finasteride/*therapeutic use MH - France MH - Humans MH - Male MH - Middle Aged MH - Patient Satisfaction MH - Prostatic Hyperplasia/*psychology/*therapy MH - Surveys and Questionnaires EDAT- 2003/03/04 04:00 MHDA- 2003/03/27 05:00 CRDT- 2003/03/04 04:00 PHST- 2003/03/04 04:00 [pubmed] PHST- 2003/03/27 05:00 [medline] PHST- 2003/03/04 04:00 [entrez] PST - ppublish SO - Therapie. 2002 Sep-Oct;57(5):473-83. PMID- 12024958 OWN - NLM STAT- MEDLINE DCOM- 20021202 LR - 20051116 IS - 0019-5499 (Print) IS - 0019-5499 (Linking) VI - 46 IP - 1 DP - 2002 Jan TI - Sleep and performance--recent trends. PG - 6-24 AB - Sleep and sleep deprivation are intimately related to performance. Sleep management of people working in different sectors of the society like multi shift workers, nurses, doctors, students in professional schools and the armed forces has a great bearing on performance, health and safety of the subject population. The detrimental effects of sleep deprivation on psychological performance are indicated as increased lapsing, cognitive slowing, memory impairment, decrease in vigilance and sustained attention and shift in optimum response capability. Its effects on physical performance are manifested as decline in ability to perform maximal exercise, self-selected walking pace and increase in perceived exertion. Sleep deprivation appears to have no effect in respect of muscle contractile properties and maximum anaerobic power. At high altitude (HA), there is a reduction in NREM sleep with frequent awakening due to hypoxia as a physiological adaptive measure to prevent accentuation of hypoxemia due to sleep-hypoventilation. Total sleep deprivation for 48 hours at high altitude can affect the acclimatization status, thermoregulation efficiency and cognitive functions. The concept of 'sleepiness' has also been studied, as it is an emerging concept for better understanding of the effects of sleep deprivation and its effects on performance. A special mention of sustained operations in the armed forces has been made keeping in mind its uniqueness in challenging the normal sleep-work schedule and its deployment in extreme environment and operational condition. This article reviews in detail the functions of sleep, its requirement and the effects of sleep deprivation on human performance. FAU - Himashree, Gidugu AU - Himashree G AD - Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi-110 054. FAU - Banerjee, P K AU - Banerjee PK FAU - Selvamurthy, W AU - Selvamurthy W LA - eng PT - Journal Article PT - Review PL - India TA - Indian J Physiol Pharmacol JT - Indian journal of physiology and pharmacology JID - 0374707 SB - IM MH - Circadian Rhythm/physiology MH - Humans MH - Psychomotor Performance/*physiology MH - Sleep/*physiology MH - Sleep Deprivation/physiopathology/psychology RF - 177 EDAT- 2002/05/25 10:00 MHDA- 2002/12/03 04:00 CRDT- 2002/05/25 10:00 PHST- 2002/05/25 10:00 [pubmed] PHST- 2002/12/03 04:00 [medline] PHST- 2002/05/25 10:00 [entrez] PST - ppublish SO - Indian J Physiol Pharmacol. 2002 Jan;46(1):6-24. PMID- 17009570 OWN - NLM STAT- MEDLINE DCOM- 20061103 LR - 20061002 IS - 1497-3715 (Print) IS - 1497-3715 (Linking) VI - 17 IP - 3 DP - 2006 Fall TI - To err is human, to share is divine. PG - 22-5 AB - Front-line health care practitioners are often safety nets preventing errors from reaching patients. Nurses in critical care environments commonly deal with high-risk patients, high-alert medications and extreme conditions, placing themselves and medication systems under greater pressures. Human error cannot be eradicated. However, the systems in which practitioners work and interact can be made safer and more fault-tolerant. When errors occur, nurses are in a unique position to provide valuable insights. Practitioner reporting and sharing of incident information internally and externally can enhance patient safety by helping to prevent recurrence of similar events. FAU - Koczmara, Christine AU - Koczmara C AD - ISMP Canada. FAU - Dueck, Carol AU - Dueck C FAU - Jelincic, Valentina AU - Jelincic V LA - eng PT - Journal Article PT - Review PL - Canada TA - Dynamics JT - Dynamics (Pembroke, Ont.) JID - 100955578 MH - Adverse Drug Reaction Reporting Systems MH - Canada MH - Causality MH - Cooperative Behavior MH - Critical Care/*organization & administration MH - Databases, Factual MH - Documentation MH - Drug Labeling MH - Drug Packaging MH - Humans MH - Information Dissemination MH - Medication Errors/methods/*nursing/*prevention & control/statistics & numerical data MH - *Nurse's Role/psychology MH - Nursing Staff, Hospital/*organization & administration/psychology MH - Risk Management/*organization & administration MH - Systems Analysis RF - 31 EDAT- 2006/10/03 09:00 MHDA- 2006/11/04 09:00 CRDT- 2006/10/03 09:00 PHST- 2006/10/03 09:00 [pubmed] PHST- 2006/11/04 09:00 [medline] PHST- 2006/10/03 09:00 [entrez] PST - ppublish SO - Dynamics. 2006 Fall;17(3):22-5. PMID- 39869536 OWN - NLM STAT- Publisher LR - 20250127 IS - 1473-6322 (Electronic) IS - 1473-6322 (Linking) DP - 2025 Jan 28 TI - Occupational allergy and climate change. LID - 10.1097/ACI.0000000000001060 [doi] AB - PURPOSE OF REVIEW: Climate change influences working conditions in various ways, affecting employee health and safety across different sectors. Climatic factors like rising temperatures, increased UV radiation, and more frequent extreme weather events pose risks to in both indoor and outdoor workers. Allergic diseases of the respiratory tract and the skin may emerge due to climate change. This review summarizes current aspects of both direct and indirect consequences of climate change and associated exposures in diverse work environments, focusing on occupational allergies. RECENT FINDINGS: Outdoor workers, in particular, are increasing susceptible to ubiquitous pollen allergens. Additionally, they may experience climate-related increases in allergens typically associated with specific workplaces, such as Cryptostroma corticale. Changes in production processes, along with altered workplaces exposures, can lead to new sensitizations and trigger allergies, representing indirect consequences of climate change. Furthermore, lifestyle changes aimed to promoting climate protection and sustainability (e.g. the introduction of insects as a protein source or using enzymes), may also contribute to the emergence of new allergens. SUMMARY: The emergence of new occupational sensitization sources from novel or modified allergen exposures must be addressed within the framework of workplace safety and health, necessitating proactive measures to safeguard workers and mitigate risks. CI - Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Raulf, Monika AU - Raulf M AD - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Germany. FAU - Annesi-Maesano, Isabella AU - Annesi-Maesano I AD - Department of Pulmonology, Allergy and Thoracic Oncology, University Hospital of Montpellier, Montpellier, France. LA - eng PT - Journal Article DEP - 20250128 PL - United States TA - Curr Opin Allergy Clin Immunol JT - Current opinion in allergy and clinical immunology JID - 100936359 SB - IM EDAT- 2025/01/27 18:21 MHDA- 2025/01/27 18:21 CRDT- 2025/01/27 13:13 PHST- 2025/01/27 18:21 [medline] PHST- 2025/01/27 18:21 [pubmed] PHST- 2025/01/27 13:13 [entrez] AID - 00130832-990000000-00180 [pii] AID - 10.1097/ACI.0000000000001060 [doi] PST - aheadofprint SO - Curr Opin Allergy Clin Immunol. 2025 Jan 28. doi: 10.1097/ACI.0000000000001060. PMID- 33733218 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210320 IS - 2624-8212 (Electronic) IS - 2624-8212 (Linking) VI - 3 DP - 2020 TI - Prognostics and Health Management of Industrial Assets: Current Progress and Road Ahead. PG - 578613 LID - 10.3389/frai.2020.578613 [doi] LID - 578613 AB - Prognostic and Health Management (PHM) systems are some of the main protagonists of the Industry 4.0 revolution. Efficiently detecting whether an industrial component has deviated from its normal operating condition or predicting when a fault will occur are the main challenges these systems aim at addressing. Efficient PHM methods promise to decrease the probability of extreme failure events, thus improving the safety level of industrial machines. Furthermore, they could potentially drastically reduce the often conspicuous costs associated with scheduled maintenance operations. The increasing availability of data and the stunning progress of Machine Learning (ML) and Deep Learning (DL) techniques over the last decade represent two strong motivating factors for the development of data-driven PHM systems. On the other hand, the black-box nature of DL models significantly hinders their level of interpretability, de facto limiting their application to real-world scenarios. In this work, we explore the intersection of Artificial Intelligence (AI) methods and PHM applications. We present a thorough review of existing works both in the contexts of fault diagnosis and fault prognosis, highlighting the benefits and the drawbacks introduced by the adoption of AI techniques. Our goal is to highlight potentially fruitful research directions along with characterizing the main challenges that need to be addressed in order to realize the promises of AI-based PHM systems. CI - Copyright © 2020 Biggio and Kastanis. FAU - Biggio, Luca AU - Biggio L AD - Data Analytics Lab, Institute of Machine Learning, Department of Computer Science, ETHZ: Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland. AD - Robotics and Automation, CSEM SA: Swiss Center for Electronics and Microtechnology S.A., Alpnach, Switzerland. FAU - Kastanis, Iason AU - Kastanis I AD - Robotics and Automation, CSEM SA: Swiss Center for Electronics and Microtechnology S.A., Alpnach, Switzerland. LA - eng PT - Journal Article PT - Review DEP - 20201109 PL - Switzerland TA - Front Artif Intell JT - Frontiers in artificial intelligence JID - 101770551 PMC - PMC7861342 OTO - NOTNLM OT - artificial intelligence OT - deep leaning OT - industry 4.0 OT - machine learning OT - predictive maintenance OT - prognostic and health management EDAT- 2021/03/19 06:00 MHDA- 2021/03/19 06:01 PMCR- 2020/11/09 CRDT- 2021/03/18 06:57 PHST- 2020/06/30 00:00 [received] PHST- 2020/09/28 00:00 [accepted] PHST- 2021/03/18 06:57 [entrez] PHST- 2021/03/19 06:00 [pubmed] PHST- 2021/03/19 06:01 [medline] PHST- 2020/11/09 00:00 [pmc-release] AID - 578613 [pii] AID - 10.3389/frai.2020.578613 [doi] PST - epublish SO - Front Artif Intell. 2020 Nov 9;3:578613. doi: 10.3389/frai.2020.578613. eCollection 2020. PMID- 23147344 OWN - NLM STAT- MEDLINE DCOM- 20140109 LR - 20121128 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 23 IP - 6 DP - 2012 Nov TI - Periodontal manifestations and ambulatorial management in a patient with Sturge-Weber syndrome. PG - 1809-11 LID - 10.1097/SCS.0b013e318271016c [doi] AB - Sturge-Weber syndrome is a nonhereditary congenital condition characterized by leptomeningeal and facial skin angiomatous malformation following the trigeminal nerve path. The intraoral angiomatosis are presented in 40% of cases and results in an important periodontal alteration, increasing the risk of bleeding during dental procedures. A 43-year-old male patient presented with port wine stain on the right side of the face, the entire hard and soft palates, the alveolar ridge, and buccal mucosa, and had an excessive accumulation of calcified masses in both supragingival and subgingival sites, with swelling and generalized inflammation throughout the gingiva and alveolar mucosa. He reported not having sanitized the area for years for fear of bleeding. Periodontal management, to remove calculus and to control gingivitis initiated in the supragingival region and gradually reaching the subgingival region to control oral microbiota, was performed with mild bleeding. The redness of the staining greatly diminished with time and the extreme halitosis of the patient also improved sharply leading to a dramatic improvement in quality of life. Ambulatory care is a feasible alternative for periodontal management that within safety limits for bleeding risks reduces the operational cost. FAU - Pagin, Otávio AU - Pagin O AD - Department of Stomatology, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. pagin@usp.br FAU - Del Neri, Nathalia Bigelli AU - Del Neri NB FAU - Battisti, Maíra de Paula Leite AU - Battisti Mde P FAU - Capelozza, Ana Lúcia Alvares AU - Capelozza AL FAU - Santos, Paulo Sérgio da Silva AU - Santos PS LA - eng PT - Case Reports PT - Journal Article PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 MH - Adult MH - *Ambulatory Care MH - Humans MH - Male MH - Periodontal Diseases/*etiology/*therapy MH - Sturge-Weber Syndrome/*complications EDAT- 2012/11/14 06:00 MHDA- 2014/01/10 06:00 CRDT- 2012/11/14 06:00 PHST- 2012/11/14 06:00 [entrez] PHST- 2012/11/14 06:00 [pubmed] PHST- 2014/01/10 06:00 [medline] AID - 10.1097/SCS.0b013e318271016c [doi] PST - ppublish SO - J Craniofac Surg. 2012 Nov;23(6):1809-11. doi: 10.1097/SCS.0b013e318271016c. PMID- 38263991 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241023 IS - 2055-2238 (Electronic) IS - 2055-2238 (Linking) VI - 10 IP - 1 DP - 2024 Feb TI - Nonlinear associations between computed tomography-measures of adiposity and long pentraxin-3 in the Multi-Ethnic Study of Atherosclerosis. PG - e708 LID - 10.1002/osp4.708 [doi] LID - e708 AB - OBJECTIVE: Long pentraxin-3 (PTX-3) is an acute phase protein associated with cardiovascular disease, lung injury, and mortality. We evaluated the association between computed tomography (CT)-measurements of adipose tissue and plasma levels of PTX-3. METHODS: We performed a cross-sectional analysis of community-dwelling adults enrolled in the multi-center Multiethnic Study of Atherosclerosis who underwent cardiac or abdominal CT and had available PTX-3 measurements. RESULTS: There was a U-shaped association between pericardial adipose tissue volume (PAT), abdominal visceral adipose tissue area (VAT), hepatic attenuation, and PTX-3 levels, with extremes of adiposity associated with greater PTX-3 levels. Using multivariable-adjusted piecewise regression models, among participants with low PAT, every 1% increase in PAT volume was associated with a 13.8% decrease in PTX-3 (95% confidence interval [CI] -21.6 to -6.0); among participants with high PAT, every 1% increase in PAT volume was associated with a 6.0% increase in PTX-3 (95% CI -0.4 to 12.5). Results were similar for abdominal VAT and hepatic attenuation. CONCLUSIONS: In a cohort of community-dwelling adults, we demonstrated a "U-shaped" association between pericardial, abdominal visceral, and hepatic adiposity with PTX3 levels, suggesting that extreme adiposity is associated with greater circulating levels of PTX3. Further work is required to identify the mechanisms linking adiposity and PTX-3. CI - © 2023 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. FAU - Anderson, Michaela R AU - Anderson MR AUID- ORCID: 0000-0001-9274-7643 AD - Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. FAU - Kim, John S AU - Kim JS AD - Department of Medicine University of Virginia Charlottesville Virginia USA. FAU - Podolanczuk, Anna AU - Podolanczuk A AD - Department of Medicine Weill Cornell Medical College New York New York USA. FAU - Ding, Jingzhong AU - Ding J AD - Department of Epidemiology and Prevention Wake Forest University Winston-Salem North Carolina USA. AD - Department of Gerontology and Geriatric Science Wake Forest University Winston-Salem North Carolina USA. FAU - Al-Naamani, Nadine AU - Al-Naamani N AD - Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. FAU - Allison, Matthew AU - Allison M AD - Department of Preventive Medicine University of California San Diego San Diego California USA. FAU - Christie, Jason AU - Christie J AD - Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. FAU - Diamond, Joshua AU - Diamond J AD - Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA. LA - eng GR - K23 HL140199/HL/NHLBI NIH HHS/United States GR - 75N92020D00005/HL/NHLBI NIH HHS/United States GR - K23 HL150280/HL/NHLBI NIH HHS/United States GR - 75N92020D00001/HL/NHLBI NIH HHS/United States GR - 75N92020D00003/HL/NHLBI NIH HHS/United States GR - 75N92020D00004/HL/NHLBI NIH HHS/United States GR - 75N92020D00007/HL/NHLBI NIH HHS/United States GR - HHSN268201500003I/HL/NHLBI NIH HHS/United States GR - 75N92020D00002/HL/NHLBI NIH HHS/United States GR - HHSN268201500003C/HL/NHLBI NIH HHS/United States GR - 75N92020D00006/HL/NHLBI NIH HHS/United States GR - K23 HL150301/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20231113 PL - United States TA - Obes Sci Pract JT - Obesity science & practice JID - 101675151 PMC - PMC10804353 OTO - NOTNLM OT - liver attenuation OT - long pentraxin‐3 OT - pericardial adipose OT - visceral adipose COIS- JSK receives grant support from the NIH/NHLBI and serves on the Data, Safety, and Monitoring Board for the University of Virginia trial of convalescent plasma. EDAT- 2024/01/24 06:42 MHDA- 2024/01/24 06:43 PMCR- 2023/11/13 CRDT- 2024/01/24 03:44 PHST- 2022/11/09 00:00 [received] PHST- 2023/08/03 00:00 [revised] PHST- 2023/08/25 00:00 [accepted] PHST- 2024/01/24 06:43 [medline] PHST- 2024/01/24 06:42 [pubmed] PHST- 2024/01/24 03:44 [entrez] PHST- 2023/11/13 00:00 [pmc-release] AID - OSP4708 [pii] AID - 10.1002/osp4.708 [doi] PST - epublish SO - Obes Sci Pract. 2023 Nov 13;10(1):e708. doi: 10.1002/osp4.708. eCollection 2024 Feb. PMID- 25595821 OWN - NLM STAT- MEDLINE DCOM- 20160204 LR - 20150315 IS - 1953-8022 (Electronic) IS - 1246-7820 (Linking) VI - 22 IP - 1 DP - 2015 Mar TI - [The transfusion practice in the hepatogastroenterology department of the Campus Teaching Hospital of Lomé (Togo)]. PG - 17-21 LID - S1246-7820(14)00270-5 [pii] LID - 10.1016/j.tracli.2014.12.003 [doi] AB - OBJECTIVE: To evaluate transfusion practice in the hepatogastroenterology department of the Campus Teaching Hospital of Lomé. METHODOLOGY: This is a respective, descriptive and analytical study conducted from January 1 to December 31, 2013 on cases of in-patients' observation in the department. The cases of in-patients of more than 15 years old, having benefited from a blood transfusion were included. FINDINGS: During the study period, 849 patients were admitted; 136 were transfused, or blood transfusion rate of 16.02%. The average age of patients was of 48.25 years with extremes of 15 and 90 years. The most transfused rhesus blood group was O positive (36.76%). Red blood cell was the most frequently used blood product (94.12%). The transfusion was performed in 58.82% of cases as a matter of emergency. Gastrointestinal bleeding were the main indications (55.88%). The average pre-transfusion hemoglobinemia was 6.51 g/dL±1.67. The average post-transfusion hemoglobinemia was 8.95 g/dL±1.75. Liver disease (cirrhosis and hepatocellular carcinoma) were the main diagnosis associated with blood transfusion (44.85%). The quantity of blood to be transfused was not calculated in 100% of cases. In 11.03% of cases, the compatibility test has not been done in the laboratory. Incidents during blood transfusion were noted in 5 cases. CONCLUSION: Blood transfusion is frequent in the department. There is a good observance of blood transfusion safety regulations. However, its practice remains to be improved. CI - Copyright © 2015 Elsevier Masson SAS. All rights reserved. FAU - Lawson-Ananissoh, L M AU - Lawson-Ananissoh LM AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. Electronic address: lawsonprosper@yahoo.fr. FAU - Bouglouga, O AU - Bouglouga O AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. FAU - El Hadji Yakoubou, R AU - El Hadji Yakoubou R AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. FAU - Bagny, A AU - Bagny A AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. FAU - Kaaga, L AU - Kaaga L AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. FAU - Redah, D AU - Redah D AD - Service d'hépato-gastro-entérologie, CHU campus de Lomé, BP 61842, Lomé, Togo. LA - fre PT - English Abstract PT - Journal Article TT - La pratique transfusionnelle dans le service d'hépato-gastroenterologie du centre hospitalier universitaire campus de Lomé (Togo). DEP - 20150113 PL - France TA - Transfus Clin Biol JT - Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine JID - 9423846 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Blood Transfusion/*statistics & numerical data MH - Female MH - Gastroenterology MH - Hospital Departments MH - Hospitals, Teaching MH - Humans MH - Male MH - Middle Aged MH - Retrospective Studies MH - Togo MH - Young Adult OTO - NOTNLM OT - Blood transfusion OT - Indication OT - Lomé OT - Sécurité transfusionnelle OT - Transfusion safety OT - Transfusion sanguine EDAT- 2015/01/18 06:00 MHDA- 2016/02/05 06:00 CRDT- 2015/01/18 06:00 PHST- 2014/11/11 00:00 [received] PHST- 2014/12/16 00:00 [accepted] PHST- 2015/01/18 06:00 [entrez] PHST- 2015/01/18 06:00 [pubmed] PHST- 2016/02/05 06:00 [medline] AID - S1246-7820(14)00270-5 [pii] AID - 10.1016/j.tracli.2014.12.003 [doi] PST - ppublish SO - Transfus Clin Biol. 2015 Mar;22(1):17-21. doi: 10.1016/j.tracli.2014.12.003. Epub 2015 Jan 13. PMID- 36243828 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221019 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 12 IP - 1 DP - 2022 Oct 15 TI - 3D printed laboratory equipment to measure bulk materials in extreme conditions. PG - 17331 LID - 10.1038/s41598-022-22114-2 [doi] LID - 17331 AB - Due to relatively new solutions in the field of 3D printing, there are few studies on the possibility of using printed elements in measuring devices. The aim of this study was to investigate the possibility of using instruments made by material extrusion 3D printing method for measurement of selected mechanical-physical properties of bulk materials. Study explores the feasibility of measuring bulk material mechanical-physical properties when there are obstacles for printing original or modified measuring instruments in common practice. To achieve the goals a series of experiments such as Schulze's ring shear tests, Freeman's FT4 shear tests, compressibility tests, and Flow Rate and Stability tests were performed with use of original aluminium or steel made instruments and 3D printed instruments from polylactic acid and acrylic styrene acrylonitrile materials, using lunar regolith simulants LHS-1 and LMS-1 produced by CLASS Exolith Lab as a sample material. The results obtained from tests with original and printed instruments were then compared. The compared values of tests showed applicability of the 3D printed measuring instruments in a 5% range of measurement deviation. The biggest advantages of the 3D printed measuring instruments were the lower weight, the ability to print on the spot, to replace a damaged part with a new 3D printed part on-demand if extremely fast results are needed or due to the logistical unavailability, customization of the standardized tests for better understanding the behaviour of the particulate materials, and cheaper manufacturing costs. CI - © 2022. The Author(s). FAU - Divis, Jan AU - Divis J AUID- ORCID: 0000-0003-3896-5492 AD - ENET Centre, Bulk Solids Centre, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. jan.divis@vsb.cz. AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. jan.divis@vsb.cz. FAU - Hlosta, Jakub AU - Hlosta J AD - ENET Centre, Bulk Solids Centre, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. FAU - Zurovec, David AU - Zurovec D AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. FAU - Rozbroj, Jiri AU - Rozbroj J AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. FAU - Kruszelnicka, Weronika AU - Kruszelnicka W AD - Department of Machines and Technical Systems, Faculty of Mechanical Engineering, Bydgoszcz University of Science and Technology, Al. Prof. S. Kaliskiego 7, 85-796, Bydgoszcz, Poland. FAU - Necas, Jan AU - Necas J AD - ENET Centre, Bulk Solids Centre, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. FAU - Zegzulka, Jiri AU - Zegzulka J AD - ENET Centre, Bulk Solids Centre, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. AD - Department of Mining Engineering and Safety, Faculty of Mining and Geology, VSB-TU Ostrava, 17. listopadu 15/2172, 708 33, Ostrava-Poruba, Czech Republic. LA - eng GR - CZ.02.2.69/0.0/0.0/19_073/0016945/Doctoral grant competition VSB-Technical University of Ostrava/ GR - CZ.02.1.01/0.0/0.0/17_049/0008407/Innovative and additive manufacturing technology -new technological solutions for 3D printing of metals and composite materials/ GR - CZ.02.1.01/0.0/0.0/17_049/0008407/Innovative and additive manufacturing technology -new technological solutions for 3D printing of metals and composite materials/ GR - CZ.02.1.01/0.0/0.0/17_049/0008407/Innovative and additive manufacturing technology -new technological solutions for 3D printing of metals and composite materials/ PT - Journal Article DEP - 20221015 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC9569391 COIS- The authors declare no competing interests. EDAT- 2022/10/16 06:00 MHDA- 2022/10/16 06:01 PMCR- 2022/10/15 CRDT- 2022/10/15 23:29 PHST- 2022/05/10 00:00 [received] PHST- 2022/10/10 00:00 [accepted] PHST- 2022/10/15 23:29 [entrez] PHST- 2022/10/16 06:00 [pubmed] PHST- 2022/10/16 06:01 [medline] PHST- 2022/10/15 00:00 [pmc-release] AID - 10.1038/s41598-022-22114-2 [pii] AID - 22114 [pii] AID - 10.1038/s41598-022-22114-2 [doi] PST - epublish SO - Sci Rep. 2022 Oct 15;12(1):17331. doi: 10.1038/s41598-022-22114-2. PMID- 28024997 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2050-1161 (Print) IS - 2050-1161 (Electronic) IS - 2050-1161 (Linking) VI - 5 IP - 1 DP - 2017 Mar TI - Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia. PG - e61-e71 LID - S2050-1161(16)30075-7 [pii] LID - 10.1016/j.esxm.2016.11.001 [doi] AB - INTRODUCTION: Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). AIM: To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. METHODS: AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). MAIN OUTCOME MEASURES: Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS). (CAG)n and (GGN)n repeats were categorized as short ([CAG]9-19, [GGN]<23), medium ([CAG]20-24, [GGN]23), or long ([CAG]25-37, [GGN]>23). RESULTS: Median age was 32 years, duration of finasteride use was 360 days, and time from finasteride discontinuation was 1,053 days. We observed several frequency differences in symptoms according to (CAG)n and (GGN)n repeat numbers. Three AMS items were worse for medium (GGN)23 than for long (GGN)>23 carriers and one item was worse for short (GGN)<23 carriers. The AMS item for decrease in sexual desire or libido was worse for short (CAG)9-19 carriers than for medium (CAG)20-24 carriers. Through the ad hoc questionnaire, significant findings in (CAG)n and/or (GGN)n repeats were obtained for penile discomfort, loss of scrotal sensitivity, scrotal discomfort, less pubic hair, loss of perceived perineal fullness, increased sperm density, involuntary muscle spasms, loss of muscle tone, increased weight (>2 kg), increased skin dryness, and onset of symptoms after finasteride use. CONCLUSION: This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR. This study showed a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Further studies are necessary to investigate the PFS pathophysiology using a precision medicine approach. CI - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Cauci, Sabina AU - Cauci S AD - Department of Medical and Biological Sciences, School of Medicine, University of Udine, Udine, Italy. Electronic address: sabina.cauci@uniud.it. FAU - Chiriacò, Giovanni AU - Chiriacò G AD - Urological Hospital Department, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. FAU - Cecchin, Erika AU - Cecchin E AD - Experimental and Clinical Pharmacology Unit, CRO Aviano National Cancer Institute, Italy. FAU - Toffoli, Giuseppe AU - Toffoli G AD - Experimental and Clinical Pharmacology Unit, CRO Aviano National Cancer Institute, Italy. FAU - Xodo, Serena AU - Xodo S AD - Hospital Department of Gynecology and Obstetrics, University Hospital Santa Maria della Misericordia, Udine, Italy. FAU - Stinco, Giuseppe AU - Stinco G AD - Department of Experimental and Clinical Medicine, University of Udine, Dermatology Clinic, University Hospital Santa Maria della Misericordia, Udine, Italy. FAU - Trombetta, Carlo AU - Trombetta C AD - Urological Hospital Department, Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy. LA - eng PT - Journal Article DEP - 20161223 PL - England TA - Sex Med JT - Sexual medicine JID - 101631053 PMC - PMC5302381 OTO - NOTNLM OT - 5α-Reductase Inhibitor OT - Androgen Receptor OT - Androgenic Alopecia OT - CAG Polymorphism OT - Erectile Dysfunction OT - Finasteride Safety OT - Finasteride Side Effects OT - GGN Polymorphism OT - Loss of Libido OT - Male Pattern Hair Loss OT - Post-Finasteride Syndrome OT - Sexual Dysfunction EDAT- 2016/12/28 06:00 MHDA- 2016/12/28 06:01 PMCR- 2016/12/23 CRDT- 2016/12/28 06:00 PHST- 2016/09/01 00:00 [received] PHST- 2016/10/26 00:00 [revised] PHST- 2016/11/10 00:00 [accepted] PHST- 2016/12/28 06:00 [pubmed] PHST- 2016/12/28 06:01 [medline] PHST- 2016/12/28 06:00 [entrez] PHST- 2016/12/23 00:00 [pmc-release] AID - S2050-1161(16)30075-7 [pii] AID - 10.1016/j.esxm.2016.11.001 [doi] PST - ppublish SO - Sex Med. 2017 Mar;5(1):e61-e71. doi: 10.1016/j.esxm.2016.11.001. Epub 2016 Dec 23. PMID- 38127155 OWN - NLM STAT- MEDLINE DCOM- 20240130 LR - 20240206 IS - 2731-7013 (Electronic) IS - 2731-7005 (Linking) VI - 75 IP - 2 DP - 2024 Feb TI - [Climate change and type I allergies at the workplace]. PG - 112-117 LID - 10.1007/s00105-023-05271-x [doi] AB - The consequences of climate change, the increasing frequency, duration and intensity of extreme events such as excessive drought, heat waves, large-scale forest fires, heavy rainfall and associated flooding also affect workers' conditions in the workplace in many ways. Allergic diseases of the respiratory tract and skin due to workplace exposure can also arise or be influenced by direct and indirect consequences of climate change. This affects outdoor workers not only through increased exposure to pollen allergens, but also through climate-related increases in typical workplace allergens. As an indirect effect of climate change, manufacturing processes and exposure at workplaces are changing, which can also cause new sensitization and allergies. Lifestyle changes, which are primarily intended to contribute to climate protection and sustainability, can also lead to new or changed products and thus to changed manufacturing processes and exposures in the workplace, so this should also be considered an indirect effect of climate change on the health of workers. The emergence of new occupational sources of sensitization due to new or changed allergen exposures must be considered in the context of occupational health and safety and requires proactive measures to protect workers. CI - © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. FAU - Raulf, Monika AU - Raulf M AD - Abteilung Kompetenz-Zentrum Allergologie/Immunologie, Institut für Prävention und Arbeitsmedizin der DGUV, Institut der Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland. monika.raulf@dguv.de. LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Klimawandel und Typ-I-Allergien im Beruf. DEP - 20231221 PL - Germany TA - Dermatologie (Heidelb) JT - Dermatologie (Heidelberg, Germany) JID - 9918384885206676 SB - IM MH - Humans MH - Climate Change MH - *Occupational Exposure/adverse effects MH - Workplace MH - *Hypersensitivity, Immediate MH - *Hypersensitivity/epidemiology OTO - NOTNLM OT - Allergen exposure OT - Occupational allergy OT - Occupational safety OT - Sensitization OT - Workplace EDAT- 2023/12/21 12:42 MHDA- 2024/01/30 12:43 CRDT- 2023/12/21 11:14 PHST- 2023/11/20 00:00 [accepted] PHST- 2024/01/30 12:43 [medline] PHST- 2023/12/21 12:42 [pubmed] PHST- 2023/12/21 11:14 [entrez] AID - 10.1007/s00105-023-05271-x [pii] AID - 10.1007/s00105-023-05271-x [doi] PST - ppublish SO - Dermatologie (Heidelb). 2024 Feb;75(2):112-117. doi: 10.1007/s00105-023-05271-x. Epub 2023 Dec 21. PMID- 29037579 OWN - NLM STAT- MEDLINE DCOM- 20181105 LR - 20181105 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 36 IP - 36 DP - 2018 Aug 28 TI - Rotarix® and RotaTeq® administration to preterm infants in the neonatal intensive care unit: Review of available evidence. PG - 5430-5434 LID - S0264-410X(17)31392-0 [pii] LID - 10.1016/j.vaccine.2017.10.013 [doi] AB - Rotavirus (RV) is the leading cause of severe acute gastroenteritis (GE) in infants worldwide. Several vaccines against RV were developed to reduce disease burden, hospitalization rates and health utilization costs. RV GE is a serious disease in preterm (PT) infants, and the administration of RV vaccine to these at-risk subjects at the proper time could have great clinical relevance. However, most data on the efficacy and safety of RV vaccinations were collected in healthy full-term infants, and few studies investigated PT infants. The lack of studies in PT infants may explain why neonatologists in several neonatal intensive care units (NICUs) do not follow the official recommendations, which indicate that RV vaccine may be administered in hospitals. Increasing neonatologists' knowledge on the efficacy and safety of RV vaccines and defining PT candidates for vaccination and the necessary precautions are extremely important to avoid potential vaccine virus transmission and improve RV vaccination coverage in PT infants. Further studies should analyse the impact of vaccination of PT infants of different gestational ages and various clinical histories in stable conditions in the NICU with a careful monitoring of adverse events to the vaccine and RV GE occurrence. Only data that confirm the efficacy and safety of RV vaccines in large numbers of PT infants with different characteristics will convince neonatologists to use RV vaccines in PT infants hospitalized in NICUs. CI - Copyright © 2017 Elsevier Ltd. All rights reserved. FAU - Esposito, Susanna AU - Esposito S AD - Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, Perugia, Italy. Electronic address: susanna.esposito@unimi.it. FAU - Pugni, Lorenza AU - Pugni L AD - NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. FAU - Mosca, Fabio AU - Mosca F AD - NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. FAU - Principi, Nicola AU - Principi N AD - Emeritus Professor of Pediatrics, Università degli Studi di Milano, Milan, Italy. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20171014 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (RotaTeq) RN - 0 (Rotavirus Vaccines) RN - 0 (Vaccines, Attenuated) SB - IM MH - Humans MH - Intensive Care Units, Neonatal/*statistics & numerical data MH - Rotavirus/immunology/*pathogenicity MH - Rotavirus Infections/immunology/prevention & control MH - Rotavirus Vaccines/therapeutic use MH - Vaccination/methods MH - Vaccines, Attenuated/therapeutic use OTO - NOTNLM OT - Acute gastroenteritis OT - Preterm infants OT - Rotarix OT - Rotateq OT - Rotavirus OT - Rotavirus vaccine EDAT- 2017/10/19 06:00 MHDA- 2018/11/06 06:00 CRDT- 2017/10/18 06:00 PHST- 2017/02/19 00:00 [received] PHST- 2017/08/19 00:00 [revised] PHST- 2017/10/05 00:00 [accepted] PHST- 2017/10/19 06:00 [pubmed] PHST- 2018/11/06 06:00 [medline] PHST- 2017/10/18 06:00 [entrez] AID - S0264-410X(17)31392-0 [pii] AID - 10.1016/j.vaccine.2017.10.013 [doi] PST - ppublish SO - Vaccine. 2018 Aug 28;36(36):5430-5434. doi: 10.1016/j.vaccine.2017.10.013. Epub 2017 Oct 14. PMID- 33861157 OWN - NLM STAT- MEDLINE DCOM- 20221109 LR - 20221115 IS - 1547-8181 (Electronic) IS - 0018-7208 (Linking) VI - 64 IP - 8 DP - 2022 Dec TI - Heat Stress Management in the Military: Wet-Bulb Globe Temperature Offsets for Modern Body Armor Systems. PG - 1306-1316 LID - 10.1177/00187208211005220 [doi] AB - OBJECTIVE: The aim of this study was to model the effect of body armor coverage on body core temperature elevation and wet-bulb globe temperature (WBGT) offset. BACKGROUND: Heat stress is a critical factor influencing the health and safety of military populations. Work duration limits can be imposed to mitigate the risk of exertional heat illness and are derived based on the environmental conditions (WBGT). Traditionally a 3°C offset to WBGT is recommended when wearing body armor; however, modern body armor systems provide a range of coverage options, which may influence thermal strain imposed on the wearer. METHOD: The biophysical properties of four military clothing ensembles of increasing ballistic protection coverage were measured on a heated sweating manikin in accordance with standard international criteria. Body core temperature elevation during light, moderate, and heavy work was modeled in environmental conditions from 16°C to 34°C WBGT using the heat strain decision aid. RESULTS: Increasing ballistic protection resulted in shorter work durations to reach a critical core temperature limit of 38.5°C. Environmental conditions, armor coverage, and work intensity had a significant influence on WBGT offset. CONCLUSION: Contrary to the traditional recommendation, the required WBGT offset was >3°C in temperate conditions (<27°C WBGT), particularly for moderate and heavy work. In contrast, a lower WBGT offset could be applied during light work and moderate work in low levels of coverage. APPLICATION: Correct WBGT offsets are important for enabling adequate risk management strategies for mitigating risks of exertional heat illness. FAU - Hunt, Andrew P AU - Hunt AP AUID- ORCID: 0000-0002-2753-7567 AD - 139261 Queensland University of Technology, Brisbane, Australia. AD - 111604 Defence Science and Technology Group, Melbourne, VIC, Australia. FAU - Potter, Adam W AU - Potter AW AD - 20041 U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA. FAU - Linnane, Denise M AU - Linnane DM AD - 111604 Defence Science and Technology Group, Melbourne, VIC, Australia. FAU - Xu, Xiaojiang AU - Xu X AD - 20041 U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA. FAU - Patterson, Mark J AU - Patterson MJ AD - 111604 Defence Science and Technology Group, Melbourne, VIC, Australia. FAU - Stewart, Ian B AU - Stewart IB AD - 139261 Queensland University of Technology, Brisbane, Australia. LA - eng PT - Journal Article DEP - 20210416 PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - Humans MH - Temperature MH - *Military Personnel MH - Hot Temperature MH - *Heat Stress Disorders/prevention & control MH - Heat-Shock Response OTO - NOTNLM OT - extreme environments OT - human performance modeling OT - physical ergonomics OT - temperature OT - work physiology EDAT- 2021/04/17 06:00 MHDA- 2022/11/10 06:00 CRDT- 2021/04/16 12:09 PHST- 2021/04/17 06:00 [pubmed] PHST- 2022/11/10 06:00 [medline] PHST- 2021/04/16 12:09 [entrez] AID - 10.1177/00187208211005220 [doi] PST - ppublish SO - Hum Factors. 2022 Dec;64(8):1306-1316. doi: 10.1177/00187208211005220. Epub 2021 Apr 16. PMID- 39763766 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250205 IS - 2692-8205 (Electronic) IS - 2692-8205 (Linking) DP - 2024 Dec 20 TI - Formulation, Characterization, and in vivo Immunogenicity of Heat-Stabilized Dissolvable Microneedles Containing a Novel VLP Vaccine. LID - 2024.12.16.628763 [pii] LID - 10.1101/2024.12.16.628763 [doi] AB - Since its introduction, vaccination has heavily improved health outcomes. However, implementing vaccination efforts can be challenging, particularly in low and middle-income countries with warmer climates. Microneedle technology has been developed for its simple and relatively painless applications of vaccines. However, no microneedle vaccine has yet been approved by the FDA. A few hurdles must be overcome, including the need to evaluate the safety and biocompatibility of the polymer used to fabricate these microneedles. Additionally, it is important to demonstrate reliable immune responses comparable to or better than those achieved through traditional administration routes. Scalability in manufacturing and the ability to maintain vaccine potency during storage and transportation are also critical factors. In this study, we developed vaccine-loaded dissolvable microneedles that showed preclinical immunogenicity after storage in extreme conditions. We developed our microneedles using the conventional micromolding technique with polyacrylic acid (PAA) polymer, incorporating a novel virus-like particle (VLP) vaccine targeting arboviruses. We performed characterization studies on these microneedles to assess needle sharpness, skin insertion force, and VLP integrity. We also investigated the thermostability of the vaccine after storing the microneedles at elevated temperatures for approximately 140 days. Finally, we evaluated the immunogenicity of this vaccine in mice, comparing transdermal (microneedle) with intramuscular (hypodermic needle) administration. We successfully fabricated and characterized VLP-loaded microneedles that could penetrate the skin and maintain vaccine integrity even after exposure to extreme storage conditions. These microneedles also elicited robust and long-lasting antibody responses similar to those achieved with intramuscular administration. FAU - Leyba, Aidan AU - Leyba A AD - Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. FAU - Francian, Alexandra AU - Francian A AD - Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. FAU - Razjmoo, Mohammad AU - Razjmoo M AD - Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. FAU - Bierle, Amelia AU - Bierle A AD - Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. FAU - Janardhana, Ranjith AU - Janardhana R AD - Department of Mechanical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States. FAU - Jackson, Nathan AU - Jackson N AD - Department of Mechanical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States. FAU - Chackerian, Bryce AU - Chackerian B AUID- ORCID: 0000-0002-5712-4739 AD - Department of Molecular Genetics and Microbiology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. FAU - Muttil, Pavan AU - Muttil P AD - Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States. LA - eng GR - P20 GM121176/GM/NIGMS NIH HHS/United States GR - R01 AI169739/AI/NIAID NIH HHS/United States PT - Journal Article PT - Preprint DEP - 20241220 PL - United States TA - bioRxiv JT - bioRxiv : the preprint server for biology JID - 101680187 PMC - PMC11702720 OTO - NOTNLM OT - Microneedles OT - cold-chain OT - thermostable OT - vaccination OT - virus-like particle COIS- Conflict of Interest B. Chackerian has equity in Metaphore Biotechnologies. EDAT- 2025/01/07 06:22 MHDA- 2025/01/07 06:23 PMCR- 2025/01/06 CRDT- 2025/01/07 04:30 PHST- 2025/01/07 06:22 [pubmed] PHST- 2025/01/07 06:23 [medline] PHST- 2025/01/07 04:30 [entrez] PHST- 2025/01/06 00:00 [pmc-release] AID - 2024.12.16.628763 [pii] AID - 10.1101/2024.12.16.628763 [doi] PST - epublish SO - bioRxiv [Preprint]. 2024 Dec 20:2024.12.16.628763. doi: 10.1101/2024.12.16.628763. PMID- 30050445 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240607 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 9 DP - 2018 TI - Autoregulation of Acetylcholine Release and Micro-Pharmacodynamic Mechanisms at Neuromuscular Junction: Selective Acetylcholinesterase Inhibitors for Therapy of Myasthenic Syndromes. PG - 766 LID - 10.3389/fphar.2018.00766 [doi] LID - 766 AB - Neuromuscular junctions (NMJs) are directly involved into such indispensable to life processes as respiration and locomotion. However, motor nerve forms only one synaptic contact at each muscle fiber. This unique configuration requires specific properties and constrains to be effective. The very high density of acetylcholine receptors (AChRs) of muscle type in synaptic cleft and an excess of acetylcholine (ACh) released under physiological conditions make this synapse extremely reliable. Nevertheless, under pathological conditions such as myasthenia gravis and congenital myasthenic syndromes, the safety factor can be markedly reduced. Drugs used for short-term symptomatic therapy of these pathological states, cause partial inhibition of cholinesterases (ChEs). These enzymes catalyze the hydrolysis of ACh, thus terminate its action on AChRs. Extension of the lifetime of ACh molecules compensates muscular AChRs abnormalities and, consequently, rescues muscle contractions. In this mini review, we will first outline the functional organization of the NMJ, and then, consider the concept of the safety factor and how it may be changed. This will be followed by a look at autoregulation of ACh release that influences the safety factor of NMJs. Finally, we will consider the morphological features of NMJs as a putative reserve to increase effectiveness of pathological muscle weakness therapy by ChEs inhibitors due to opportunity to use micro-pharmacodynamic mechanisms. FAU - Petrov, Konstantin A AU - Petrov KA AD - A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia. AD - Neuropharmacology Lab, Kazan Federal University, Kazan, Russia. FAU - Nikolsky, Evgeny E AU - Nikolsky EE AD - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of Russian Academy of Sciences, Kazan, Russia. FAU - Masson, Patrick AU - Masson P AD - Neuropharmacology Lab, Kazan Federal University, Kazan, Russia. LA - eng PT - Journal Article PT - Review DEP - 20180712 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC6052098 OTO - NOTNLM OT - cholinesterases OT - congenital myasthenic syndromes OT - micro-pharmacodynamic mechanisms OT - myasthenia gravis OT - neuromuscular junction EDAT- 2018/07/28 06:00 MHDA- 2018/07/28 06:01 PMCR- 2018/07/12 CRDT- 2018/07/28 06:00 PHST- 2018/04/10 00:00 [received] PHST- 2018/06/25 00:00 [accepted] PHST- 2018/07/28 06:00 [entrez] PHST- 2018/07/28 06:00 [pubmed] PHST- 2018/07/28 06:01 [medline] PHST- 2018/07/12 00:00 [pmc-release] AID - 10.3389/fphar.2018.00766 [doi] PST - epublish SO - Front Pharmacol. 2018 Jul 12;9:766. doi: 10.3389/fphar.2018.00766. eCollection 2018. PMID- 38414766 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240229 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 15 DP - 2024 TI - Biological functions at high pressure: transcriptome response of Shewanella oneidensis MR-1 to hydrostatic pressure relevant to Titan and other icy ocean worlds. PG - 1293928 LID - 10.3389/fmicb.2024.1293928 [doi] LID - 1293928 AB - High hydrostatic pressure (HHP) is a key driver of life's evolution and diversification on Earth. Icy moons such as Titan, Europa, and Enceladus harbor potentially habitable high-pressure environments within their subsurface oceans. Titan, in particular, is modeled to have subsurface ocean pressures ≥ 150 MPa, which are above the highest pressures known to support life on Earth in natural ecosystems. Piezophiles are organisms that grow optimally at pressures higher than atmospheric (0.1 MPa) pressure and have specialized adaptations to the physical constraints of high-pressure environments - up to ~110 MPa at Challenger Deep, the highest pressure deep-sea habitat explored. While non-piezophilic microorganisms have been shown to survive short exposures at Titan relevant pressures, the mechanisms of their survival under such conditions remain largely unelucidated. To better understand these mechanisms, we have conducted a study of gene expression for Shewanella oneidensis MR-1 using a high-pressure experimental culturing system. MR-1 was subjected to short-term (15 min) and long-term (2 h) HHP of 158 MPa, a value consistent with pressures expected near the top of Titan's subsurface ocean. We show that MR-1 is metabolically active in situ at HHP and is capable of viable growth following 2 h exposure to 158 MPa, with minimal pressure training beforehand. We further find that MR-1 regulates 264 genes in response to short-term HHP, the majority of which are upregulated. Adaptations include upregulation of the genes argA, argB, argC, and argF involved in arginine biosynthesis and regulation of genes involved in membrane reconfiguration. MR-1 also utilizes stress response adaptations common to other environmental extremes such as genes encoding for the cold-shock protein CspG and antioxidant defense related genes. This study suggests Titan's ocean pressures may not limit life, as microorganisms could employ adaptations akin to those demonstrated by terrestrial organisms. CI - Copyright © 2024 Malas, Russo, Bollengier, Malaska, Lopes, Kenig and Meyer-Dombard. FAU - Malas, Judy AU - Malas J AD - Department of Earth and Environmental Sciences, University of Illinois Chicago, Chicago, IL, United States. FAU - Russo, Daniel C AU - Russo DC AD - Department of Earth and Environmental Sciences, University of Illinois Chicago, Chicago, IL, United States. FAU - Bollengier, Olivier AU - Bollengier O AD - Nantes Université, Univ Angers, Le Mans Université, CNRS, Laboratoire de Planétologie et Géosciences, LPG UMR 6112, Nantes, France. FAU - Malaska, Michael J AU - Malaska MJ AD - Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, United States. FAU - Lopes, Rosaly M C AU - Lopes RMC AD - Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, United States. FAU - Kenig, Fabien AU - Kenig F AD - Department of Earth and Environmental Sciences, University of Illinois Chicago, Chicago, IL, United States. FAU - Meyer-Dombard, D'Arcy R AU - Meyer-Dombard DR AD - Department of Earth and Environmental Sciences, University of Illinois Chicago, Chicago, IL, United States. LA - eng PT - Journal Article DEP - 20240213 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC10896736 OTO - NOTNLM OT - Europa OT - Titan OT - astrobiology OT - biosignatures OT - food safety OT - high hydrostatic pressure OT - ocean worlds OT - transcriptome COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2024/02/28 06:45 MHDA- 2024/02/28 06:46 PMCR- 2024/02/13 CRDT- 2024/02/28 03:52 PHST- 2023/09/13 00:00 [received] PHST- 2024/01/25 00:00 [accepted] PHST- 2024/02/28 06:46 [medline] PHST- 2024/02/28 06:45 [pubmed] PHST- 2024/02/28 03:52 [entrez] PHST- 2024/02/13 00:00 [pmc-release] AID - 10.3389/fmicb.2024.1293928 [doi] PST - epublish SO - Front Microbiol. 2024 Feb 13;15:1293928. doi: 10.3389/fmicb.2024.1293928. eCollection 2024. PMID- 36143423 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220928 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 12 IP - 9 DP - 2022 Sep 6 TI - In Vitro Evaluation of Weizmannia coagulans Strain LMG S-31876 Isolated from Fermented Rice for Potential Probiotic Properties, Safety Assessment and Technological Properties. LID - 10.3390/life12091388 [doi] LID - 1388 AB - Bacillus coagulans, which has been taxonomically reclassified as Weizmannia coagulans, has been the focus of research due to its wide distribution in fermented foods, probiotic properties, and tolerance to extreme environments. The purpose of this study was to characterise putative probiotic bacteria in a fermented rice sample, followed by an in vitro screening of presumptive probiotic properties and a safety assessment to ensure their safety for human consumption. The predominant isolate was Gram-positive, rod-shaped, catalase-positive, spore-forming, motile, and facultatively anaerobic. The biochemical test and 16S rDNA sequencing identify the isolate as Weizmannia coagulans strain LMG S-31876. The strain showed significant viability in acidic gastric juice, pancreatin, and bile. The strain showed tolerance to 5% NaCl, and a low-to-moderate percentage of hydrophobicity and auto-aggregation was recorded. It met all safety criteria, including haemolytic activity, DNase activity, antibiotic sensitivity, and growth inhibition of other bacteria. Evaluation of its technological properties showed positive results for amylolytic and lipolytic activities; however, negative results were obtained for proteolytic activity. It could be concluded from the gathered data that W. coagulans strain LMG S-31876 isolated from fermented rice, might serve as a potential functional probiotic food. However, extended follow-up durations and larger-scale trials by assessing the therapeutic effects in managing various clinical gastrointestinal conditions are required to warranty such effects. FAU - Sreenadh, Madapati AU - Sreenadh M AD - Abode Biotec India Private Limited, MLA Colony, Banjara Hills, Hyderabad 500033, Telangana, India. FAU - Kumar, Kallur Ranjith AU - Kumar KR AD - Abode Biotec India Private Limited, MLA Colony, Banjara Hills, Hyderabad 500033, Telangana, India. FAU - Nath, Soumitra AU - Nath S AUID- ORCID: 0000-0003-3678-2297 AD - Department of Biotechnology, Gurucharan College, Silchar 788004, Assam, India. LA - eng PT - Journal Article DEP - 20220906 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC9504688 OTO - NOTNLM OT - Weizmannia coagulans OT - antibiotic OT - artificial gastric juice OT - fermented rice OT - lipolytic activity OT - probiotic COIS- The authors declare no conflict of interest. EDAT- 2022/09/24 06:00 MHDA- 2022/09/24 06:01 PMCR- 2022/09/06 CRDT- 2022/09/23 01:30 PHST- 2022/07/25 00:00 [received] PHST- 2022/08/27 00:00 [revised] PHST- 2022/08/29 00:00 [accepted] PHST- 2022/09/23 01:30 [entrez] PHST- 2022/09/24 06:00 [pubmed] PHST- 2022/09/24 06:01 [medline] PHST- 2022/09/06 00:00 [pmc-release] AID - life12091388 [pii] AID - life-12-01388 [pii] AID - 10.3390/life12091388 [doi] PST - epublish SO - Life (Basel). 2022 Sep 6;12(9):1388. doi: 10.3390/life12091388. PMID- 38141083 OWN - NLM STAT- MEDLINE DCOM- 20231225 LR - 20240112 IS - 1573-2959 (Electronic) IS - 0167-6369 (Linking) VI - 196 IP - 1 DP - 2023 Dec 23 TI - Glyphosate spraying exacerbates nitrogen and phosphorus loss in karst slope farmland. PG - 80 LID - 10.1007/s10661-023-12238-x [doi] AB - Glyphosate herbicide is an indispensable material in agricultural production. In order to explore the potential environmental effects of glyphosate application in karst slope farmland, this paper used a variable slope steel tank to simulate the surface microtopography and underground pore structure characteristics of karst slope farmland, and combined with artificial rainfall experiments to explore the migration path of glyphosate in karst slope farmland and the impact of spraying glyphosate on soil nitrogen and phosphorus loss. The results showed that under the condition of heavy rain, glyphosate in karst slope farmland was mainly transported and diffused by surface runoff, supplemented by underground runoff; secondly, in different hydrological paths, glyphosate directly affected the content of nitrogen and phosphorus in runoff, and all showed extremely significant positive correlation (p < 0.001). In addition, rainfall conditions such as rainfall intensity, rainfall duration, and runoff affected the content of nitrogen and phosphorus in runoff to varying degrees. In conclusion, the application of glyphosate significantly increased the content of nitrogen and phosphorus in different runoff and accelerated the loss of nitrogen and phosphorus from soil, which not only led to soil degradation, but also threatened the safety of aquatic ecosystem. Therefore, in the prevention and control of agricultural non-point source pollution, the threat of glyphosate to the surrounding aquatic ecosystem cannot be ignored, especially in karst areas with frequent rainstorms and serious water erosion, long-term monitoring and risk assessment of glyphosate are needed. CI - © 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Zhang, You AU - Zhang Y AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Tongren Polytechnic College, Tongren, 554300, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. FAU - Yan, Youjin AU - Yan Y AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. FAU - Dai, Quanhou AU - Dai Q AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. qhdairiver@163.com. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. qhdairiver@163.com. FAU - Tan, Juan AU - Tan J AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. FAU - Wang, Chenyang AU - Wang C AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. FAU - Zhou, Hong AU - Zhou H AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. FAU - Hu, Zeyin AU - Hu Z AD - College of Forestry, Guizhou University, Guiyang, 550025, People's Republic of China. AD - Institute of Soil Erosion and Ecological Restoration, Guizhou University, Guiyang, 550025, People's Republic of China. LA - eng GR - 42167044/Regional Fund of National Natural Science Foundation of China/ GR - 42007067/National Natural Science Foundation of China/ GR - [2020]1Y176/Science and Technology Plan Project of Guizhou Province/ GR - KT202205/Guizhou Provincial Water Conservancy Science and Technology Projects/ PT - Journal Article DEP - 20231223 PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 27YLU75U4W (Phosphorus) RN - 4632WW1X5A (Glyphosate) RN - N762921K75 (Nitrogen) RN - 0 (Soil) SB - IM MH - Farms MH - *Phosphorus/analysis MH - *Glyphosate MH - Nitrogen/analysis MH - Ecosystem MH - Environmental Monitoring MH - Soil/chemistry MH - China MH - Rain MH - Water Movements OTO - NOTNLM OT - Agricultural non-point source pollution OT - Glyphosate OT - Karst slope farmland OT - Nitrogen OT - Phosphorus EDAT- 2023/12/23 12:45 MHDA- 2023/12/25 06:41 CRDT- 2023/12/23 11:13 PHST- 2023/10/27 00:00 [received] PHST- 2023/12/14 00:00 [accepted] PHST- 2023/12/25 06:41 [medline] PHST- 2023/12/23 12:45 [pubmed] PHST- 2023/12/23 11:13 [entrez] AID - 10.1007/s10661-023-12238-x [pii] AID - 10.1007/s10661-023-12238-x [doi] PST - epublish SO - Environ Monit Assess. 2023 Dec 23;196(1):80. doi: 10.1007/s10661-023-12238-x. PMID- 30271914 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200111 IS - 2399-3642 (Electronic) IS - 2399-3642 (Linking) VI - 1 DP - 2018 TI - Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions. PG - 28 LID - 10.1038/s42003-018-0032-8 [doi] LID - 28 AB - The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress conditions to investigate the influence of protein degradation on structure-function. Extensive purification and characterization enabled identification and functional assessment of the physiological degradation of chemical modification sites in the variable complementarity-determining regions (CDRs) and conserved region of trastuzumab. We demonstrate that the degradation of the solvent-accessible residues located in the CDR and the conserved fragment crystallizable region (Fc) occurs faster in vivo (within days) compared to the levels observed for bio-process and real-time storage conditions. These results hence question the rationality of extreme monitoring of low level alterations in such chemical modifications as critical patient safety parameters in product quality control testing, given that these modifications merely mirror the natural/physiological aging process of endogenous antibodies. FAU - Schmid, Ingrid AU - Schmid I AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Bonnington, Lea AU - Bonnington L AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Gerl, Monika AU - Gerl M AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Bomans, Katrin AU - Bomans K AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Thaller, Anna Louisa AU - Thaller AL AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Wagner, Katharina AU - Wagner K AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Schlothauer, Tilman AU - Schlothauer T AD - Pharma Research and Early Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Falkenstein, Roberto AU - Falkenstein R AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Zimmermann, Boris AU - Zimmermann B AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Kopitz, Jürgen AU - Kopitz J AD - Department of Applied Tumor Biology, Institute of Pathology, Medical School of the Ruprecht-Karls-University, Im Neuenheimer Feld 224, Heidelberg, 69120, Germany. FAU - Hasmann, Max AU - Hasmann M AD - Pharma Research and Early Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Bauss, Frieder AU - Bauss F AD - Pharma Research and Early Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Haberger, Markus AU - Haberger M AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Reusch, Dietmar AU - Reusch D AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. FAU - Bulau, Patrick AU - Bulau P AUID- ORCID: 0000-0002-7121-2954 AD - Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg, 82377, Germany. patrick.bulau@roche.com. LA - eng PT - Journal Article DEP - 20180405 PL - England TA - Commun Biol JT - Communications biology JID - 101719179 PMC - PMC6123738 COIS- The authors declare no competing interests. EDAT- 2018/10/03 06:00 MHDA- 2018/10/03 06:01 PMCR- 2018/04/05 CRDT- 2018/10/02 06:00 PHST- 2017/10/26 00:00 [received] PHST- 2018/03/12 00:00 [accepted] PHST- 2018/10/02 06:00 [entrez] PHST- 2018/10/03 06:00 [pubmed] PHST- 2018/10/03 06:01 [medline] PHST- 2018/04/05 00:00 [pmc-release] AID - 10.1038/s42003-018-0032-8 [pii] AID - 32 [pii] AID - 10.1038/s42003-018-0032-8 [doi] PST - epublish SO - Commun Biol. 2018 Apr 5;1:28. doi: 10.1038/s42003-018-0032-8. eCollection 2018. PMID- 8947408 OWN - NLM STAT- MEDLINE DCOM- 19970226 LR - 20170214 IS - 0363-5465 (Print) IS - 0363-5465 (Linking) VI - 24 IP - 6 DP - 1996 Nov-Dec TI - Differences in friction and torsional resistance in athletic shoe-turf surface interfaces. PG - 834-42 AB - This study evaluated the shoe-surface interaction of 15 football shoes made by 3 manufacturers in both anterior translation and rotation using a specially designed pneumatic testing system. The shoes included traditional cleated football shoes, "court" shoes (basketball-style shoes), molded-cleat shoes, and turf shoes. Under an 11.35-kg (25-pound) axial load, all shoes were tested on synthetic turf under wet and dry conditions and on natural stadium grass. Test-retest reliability, as calculated using the Pearson Product-Moment Correlation test, was 0.85 for force of translation and 0.55 for the moment of rotation. The wet versus dry surface values on translation were significantly different for rotation about the tibial axis. Spatting, which is protective taping of the ankle and heel applied on the outside of the shoe, resulted in a reduction of forces generated in both translation and rotation. No overall difference between shoes on grass versus AstroTurf was noted. However, there were significant differences for cleated and turf shoes. Shoes tested in conditions for which they were not designed exhibited reproducible excessive or extreme minimal friction characteristics that may have safety implications. On the basis of this study, we urge shoe manufacturers to display suggested indications and playing surface conditions for which their shoes are recommended. FAU - Heidt, R S Jr AU - Heidt RS Jr AD - Wellington Orthopaedic & Sports Medicine, Cincinnati, Ohio, USA. FAU - Dormer, S G AU - Dormer SG FAU - Cawley, P W AU - Cawley PW FAU - Scranton, P E Jr AU - Scranton PE Jr FAU - Losse, G AU - Losse G FAU - Howard, M AU - Howard M LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Sports Med JT - The American journal of sports medicine JID - 7609541 SB - IM MH - Equipment Design MH - Evaluation Studies as Topic MH - Football MH - Friction MH - Humans MH - Reproducibility of Results MH - *Shoes EDAT- 1996/11/01 00:00 MHDA- 2001/03/28 10:01 CRDT- 1996/11/01 00:00 PHST- 1996/11/01 00:00 [pubmed] PHST- 2001/03/28 10:01 [medline] PHST- 1996/11/01 00:00 [entrez] AID - 10.1177/036354659602400621 [doi] PST - ppublish SO - Am J Sports Med. 1996 Nov-Dec;24(6):834-42. doi: 10.1177/036354659602400621. PMID- 36595365 OWN - NLM STAT- MEDLINE DCOM- 20230224 LR - 20230306 IS - 1943-569X (Electronic) IS - 0003-1488 (Linking) VI - 261 IP - 3 DP - 2023 Jan 2 TI - Retrospective analysis describes safety of therapeutic joint injections in dogs. PG - 397-402 LID - 10.2460/javma.22.11.0483 [doi] AB - OBJECTIVE: To retrospectively investigate the safety of canine therapeutic IA injections, describing and correlating adverse events with the number of injections per visit, joint injected, signalment, body condition score, type, and volume of injectate. SAMPLE: There were 505 joint injections across 283 visits for 178 client-owned dogs, including the shoulder, elbow, carpus, hip, stifle, tarsus, and metacarpophalangeal. PROCEDURES: A search was performed of the Cornell University Hospital for Animals medical records for relevant data, identifying dogs treated with therapeutic joint injections and rechecked between 2010 and 2022. RESULTS: Minor complications were noted in 70 of 283 visits and included transient soreness (18.4%, lasting a median of 2 days; range, 1 to 20 days) and gastroenteritis (6.8%). One case of septic arthritis (1/505 joints), which possessed risks of a hematogenous source, was the only potential major complication. Soreness was not correlated with the number of joints injected per visit. Larger volumes of injectate normalized to body size were more likely to be associated with transient soreness in the stifle and tarsus. Across injectates, only stem cells had significantly increased odds of soreness. Gastroenteritis was not associated with the type of injectate. CLINICAL RELEVANCE: Therapeutic joint injections in dogs are safe, with an extremely low risk of major adverse effects. Transient soreness is a commonly expected minor adverse event. The use of stem cells or larger injectate volumes (confined to the stifle and smaller distal joints) may be more likely to invoke discomfort. FAU - Miller, Allison V AU - Miller AV FAU - Carney, Patrick C AU - Carney PC FAU - Markmann, Alexandra AU - Markmann A FAU - Frye, Christopher W AU - Frye CW LA - eng PT - Journal Article DEP - 20230102 PL - United States TA - J Am Vet Med Assoc JT - Journal of the American Veterinary Medical Association JID - 7503067 SB - IM MH - Dogs MH - Animals MH - Retrospective Studies MH - Stifle MH - *Arthritis, Infectious/veterinary MH - *Elbow Joint MH - *Dog Diseases EDAT- 2023/01/04 06:00 MHDA- 2023/02/25 06:00 CRDT- 2023/01/03 12:23 PHST- 2023/01/04 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2023/01/03 12:23 [entrez] AID - 10.2460/javma.22.11.0483 [doi] PST - epublish SO - J Am Vet Med Assoc. 2023 Jan 2;261(3):397-402. doi: 10.2460/javma.22.11.0483. PMID- 26206634 OWN - NLM STAT- MEDLINE DCOM- 20151005 LR - 20220410 IS - 1879-1190 (Electronic) IS - 1072-7515 (Linking) VI - 221 IP - 2 DP - 2015 Aug TI - Per-Oral Endoscopic Myotomy: A Series of 500 Patients. PG - 256-64 LID - S1072-7515(15)00279-3 [pii] LID - 10.1016/j.jamcollsurg.2015.03.057 [doi] AB - BACKGROUND: After the first case of per-oral endoscopic myotomy (POEM) at our institution in 2008, the procedure was quickly accepted as an alternative to surgical myotomy and is now established as an excellent treatment option for achalasia. This study aimed to examine the safety and outcomes of POEM at our institution. STUDY DESIGN: Per-oral endoscopic myotomy was performed on 500 consecutive achalasia patients at our institution between September 2008 and November 2013. A review of prospectively collected data was conducted, including procedure time, myotomy location and length, adverse events, and patient data with short- (2 months) and long-term (1 and 3 years) follow-up. RESULTS: Per-oral endoscopic myotomy was successfully completed in all patients, with adverse events observed in 3.2%. Two months post-POEM, significant reductions in symptom scores (Eckardt score 6.0 ± 3.0 vs 1.0 ± 2.0, p < 0.0001) and lower esophageal sphincter (LES) pressures (25.4 ± 17.1 vs 13.4 ± 5.9 mmHg, p < 0.0001) were achieved, and this persisted at 3 years post-POEM. Gastroesophageal reflux was seen in 16.8% of patients at 2 months and 21.3% at 3-year follow-up. CONCLUSIONS: Per-oral endoscopic myotomy was successfully completed in all cases, even when extended indications (extremes of age, previous interventions, or sigmoid esophagus) were used. Adverse events were rare (3.2%), and there were no mortalities. Significant improvements in Eckardt scores and LES pressures were seen at 2 months, 1 year, and 3 years post-POEM. Based on our large series, POEM is a safe and effective treatment for achalasia; there are relatively few contraindications, and the procedure may be used as either first- or second-line therapy. CI - Copyright © 2015. Published by Elsevier Inc. FAU - Inoue, Haruhiro AU - Inoue H AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. Electronic address: haruinoue@yahoo.co.jp. FAU - Sato, Hiroki AU - Sato H AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. FAU - Ikeda, Haruo AU - Ikeda H AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. FAU - Onimaru, Manabu AU - Onimaru M AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. FAU - Sato, Chiaki AU - Sato C AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. FAU - Minami, Hitomi AU - Minami H AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. FAU - Yokomichi, Hiroshi AU - Yokomichi H AD - Division of Medicine, Graduate School Department of Interdisciplinary Research, University of Yamanashi, Yamanashi, Japan. FAU - Kobayashi, Yasutoshi AU - Kobayashi Y AD - Kobayashi Internal Medicine Clinic, Kobe, Japan. FAU - Grimes, Kevin L AU - Grimes KL AD - Digestive Disease Center, Showa University, Koto Toyosu Hospital, Tokyo, Japan. FAU - Kudo, Shin-ei AU - Kudo SE AD - Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20150411 PL - United States TA - J Am Coll Surg JT - Journal of the American College of Surgeons JID - 9431305 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Child MH - Child, Preschool MH - Esophageal Achalasia/*surgery MH - Esophageal Sphincter, Lower/*surgery MH - Esophagoscopy/*methods MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Postoperative Complications MH - Treatment Outcome MH - Young Adult EDAT- 2015/07/25 06:00 MHDA- 2015/10/06 06:00 CRDT- 2015/07/25 06:00 PHST- 2014/12/15 00:00 [received] PHST- 2015/03/04 00:00 [revised] PHST- 2015/03/15 00:00 [accepted] PHST- 2015/07/25 06:00 [entrez] PHST- 2015/07/25 06:00 [pubmed] PHST- 2015/10/06 06:00 [medline] AID - S1072-7515(15)00279-3 [pii] AID - 10.1016/j.jamcollsurg.2015.03.057 [doi] PST - ppublish SO - J Am Coll Surg. 2015 Aug;221(2):256-64. doi: 10.1016/j.jamcollsurg.2015.03.057. Epub 2015 Apr 11. PMID- 33233076 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 137 DP - 2020 Nov TI - Multilevel modelling as a tool to include variability and uncertainty in quantitative microbiology and risk assessment. Thermal inactivation of Listeria monocytogenes as proof of concept. PG - 109374 LID - S0963-9969(20)30399-9 [pii] LID - 10.1016/j.foodres.2020.109374 [doi] AB - Variability is inherent in biology and also substantial for microbial populations. In the context of food safety risk assessment, it refers to differences in the response of different bacterial strains (between-strain variability) and different cells (within-strain variability) to the same condition (e.g. inactivation treatment). However, its quantification based on empirical observations and its incorporation in predictive models is a challenge for both experimental design and (statistical) analysis. In this article we propose the use of multilevel models to quantify (different levels of) variability and uncertainty and include them in the predictions. As proof of concept, we analyse the microbial inactivation of Listeria monocytogenes to thermal treatments including different levels of variability (between-strain and within-strain) and uncertainty. The relationship between the microbial count and time was expressed using a (non-linear) Weibullian model. Moreover, we defined stochastic hypotheses to describe the different types of variation at the level of the kinetic parameters, as well as in the observations (microbial counts). The model parameters (kinetic parameters and variances) are estimated using Bayesian statistics. The multilevel approach was compared against an analogous, single-level model. The multilevel methodology shrinks extreme parameter estimates towards the mean according to uncertainty, thus mitigating overfitting. In addition, this approach enables to easily incorporate different levels of variation (between-strain and/or within-strain variability and/or uncertainty) in the predictions. On the other hand, multilevel (Bayesian) models are more complex to define, implement, analyse and communicate than single-level models. Nevertheless, their ability to incorporate different sources of variability in predictions make them very suitable for Quantitative Microbial Risk Assessment. CI - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Garre, Alberto AU - Garre A AD - Food Microbiology, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, the Netherlands. FAU - Zwietering, Marcel H AU - Zwietering MH AD - Food Microbiology, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, the Netherlands. FAU - den Besten, Heidy M W AU - den Besten HMW AD - Food Microbiology, Wageningen University & Research, P.O. Box 17, 6700 AA Wageningen, the Netherlands. Electronic address: heidy.denbesten@wur.nl. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200602 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 SB - IM MH - Bayes Theorem MH - Food Microbiology MH - *Listeria monocytogenes MH - Risk Assessment MH - Uncertainty OTO - NOTNLM OT - Bayesian statistics OT - Exposure assessment OT - Food safety OT - Hierarchical models OT - Predictive microbiology OT - Variance analysis EDAT- 2020/11/26 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/11/25 01:01 PHST- 2020/01/22 00:00 [received] PHST- 2020/05/27 00:00 [revised] PHST- 2020/05/31 00:00 [accepted] PHST- 2020/11/25 01:01 [entrez] PHST- 2020/11/26 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] AID - S0963-9969(20)30399-9 [pii] AID - 10.1016/j.foodres.2020.109374 [doi] PST - ppublish SO - Food Res Int. 2020 Nov;137:109374. doi: 10.1016/j.foodres.2020.109374. Epub 2020 Jun 2. PMID- 38986358 OWN - NLM STAT- MEDLINE DCOM- 20240824 LR - 20240824 IS - 1525-3171 (Electronic) IS - 0032-5791 (Print) IS - 0032-5791 (Linking) VI - 103 IP - 9 DP - 2024 Sep TI - Whole genome resequencing reveals the adaptability of native chickens to drought, tropical and frigid environments in Xinjiang. PG - 103947 LID - S0032-5791(24)00526-1 [pii] LID - 10.1016/j.psj.2024.103947 [doi] LID - 103947 AB - Chickens exhibit extensive genetic diversity and are distributed worldwide. Different chicken breeds have evolved to thrive in diverse environmental conditions. However, research on the genetic mechanisms underlying chicken adaptation to extreme environments, such as tropical, frigid and drought-prone regions, remains limited. In this study, we conducted whole-genome sequencing of 240 individuals from six native chicken breeds in Xinjiang, China, as well as 4 publicly available chicken breeds inhabiting regions with varying annual precipitations, temperatures, and altitudes. Our analysis revealed several genetic variants among the examined breeds. Furthermore, we investigated the genetic diversity and population structure of breeds residing in extreme drought and temperature environments by comparing them. Notably, native chicken breeds exhibited different genetic diversity and population structures. Moreover, we identified candidate genes associated with chicken adaptability to the environment, such as CORO2A, CTNNA3, AGMO, GRID2, BBOX1, COL3A1, INSR, SOX5, MAP2 and PLPPR1. Additionally, pathways such as lysosome, cysteine and methionine metabolism, glycosaminoglycan degradation, and Wnt signaling may be play crucial roles in regulating chicken adaptation to drought environments. Overall, these findings contribute to our understanding of the genetic mechanisms governing chicken adaptation to extreme environments, and also offer insights for enhancing the resilience of chicken breeds to different climatic conditions. CI - Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Lihua AU - Zhang L AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang 310021, China. FAU - Li, Haiying AU - Li H AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. Electronic address: lhy-3@163.com. FAU - Zhao, Xiaoyu AU - Zhao X AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. FAU - Wu, Yingping AU - Wu Y AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. FAU - Li, Jiahui AU - Li J AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. FAU - Yao, Yingying AU - Yao Y AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. FAU - Yao, Yang AU - Yao Y AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. FAU - Wang, Lin AU - Wang L AD - College of Animal Science, Xinjiang Agricultural University, Urumqi, China. LA - eng PT - Journal Article DEP - 20240619 PL - England TA - Poult Sci JT - Poultry science JID - 0401150 SB - IM MH - Animals MH - *Chickens/genetics/physiology MH - *Droughts MH - China MH - *Adaptation, Physiological/genetics MH - Whole Genome Sequencing/veterinary MH - Genetic Variation MH - Tropical Climate PMC - PMC11295967 OTO - NOTNLM OT - candidate gene OT - chicken OT - genetic variant OT - whole genome sequencing COIS- DISCLOSURES The authors declare no conflicts of interest. EDAT- 2024/07/11 00:42 MHDA- 2024/08/26 12:40 PMCR- 2024/06/19 CRDT- 2024/07/10 18:10 PHST- 2024/02/27 00:00 [received] PHST- 2024/05/17 00:00 [revised] PHST- 2024/06/03 00:00 [accepted] PHST- 2024/08/26 12:40 [medline] PHST- 2024/07/11 00:42 [pubmed] PHST- 2024/07/10 18:10 [entrez] PHST- 2024/06/19 00:00 [pmc-release] AID - S0032-5791(24)00526-1 [pii] AID - 103947 [pii] AID - 10.1016/j.psj.2024.103947 [doi] PST - ppublish SO - Poult Sci. 2024 Sep;103(9):103947. doi: 10.1016/j.psj.2024.103947. Epub 2024 Jun 19. PMID- 25728307 OWN - NLM STAT- MEDLINE DCOM- 20161213 LR - 20161230 IS - 1469-8986 (Electronic) IS - 0048-5772 (Linking) VI - 52 IP - 7 DP - 2015 Jul TI - Task complexity modulates pilot electroencephalographic activity during real flights. PG - 951-6 LID - 10.1111/psyp.12419 [doi] AB - Most research connecting task performance and neural activity to date has been conducted in laboratory conditions. Thus, field studies remain scarce, especially in extreme conditions such as during real flights. Here, we investigated the effects of flight procedures of varied complexity on the in-flight EEG activity of military helicopter pilots. Flight procedural complexity modulated the EEG power spectrum: highly demanding procedures (i.e., takeoff and landing) were associated with higher EEG power in the higher frequency bands, whereas less demanding procedures (i.e., flight exercises) were associated with lower EEG power over the same frequency bands. These results suggest that EEG recordings may help to evaluate an operator's cognitive performance in challenging real-life scenarios, and thus could aid in the prevention of catastrophic events. CI - © 2015 Society for Psychophysiological Research. FAU - Di Stasi, Leandro L AU - Di Stasi LL AD - Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain. AD - Joint Center University of Granada-Spanish Army Training and Doctrine Command, Granada, Spain. AD - College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA. AD - Department of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, USA. FAU - Diaz-Piedra, Carolina AU - Diaz-Piedra C AD - Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain. AD - College of Nursing and Health Innovation, Arizona State University, Phoenix, Arizona, USA. FAU - Suárez, Juan AU - Suárez J AD - Spanish Air Force Helicopter School, 78th Air Base Wing, Armilla, Spain. FAU - McCamy, Michael B AU - McCamy MB AD - Department of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, USA. FAU - Martinez-Conde, Susana AU - Martinez-Conde S AD - Department of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, USA. AD - SUNY Downstate Medical Center, New York, New York, USA. FAU - Roca-Dorda, Joaquín AU - Roca-Dorda J AD - University Centre of Defence, Spanish Air Force Academy, San Javier, Spain. FAU - Catena, Andrés AU - Catena A AD - Mind, Brain, and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150225 PL - United States TA - Psychophysiology JT - Psychophysiology JID - 0142657 SB - IM MH - Adult MH - Aircraft MH - *Aviation MH - *Brain Waves MH - Electroencephalography MH - Humans MH - Male MH - *Military Personnel MH - Task Performance and Analysis MH - Young Adult OTO - NOTNLM OT - Descriptors: EEG OT - Fatigue OT - Neuroergonomics OT - Safety OT - Simulation OT - Training EDAT- 2015/03/03 06:00 MHDA- 2016/12/15 06:00 CRDT- 2015/03/03 06:00 PHST- 2014/08/11 00:00 [received] PHST- 2015/01/17 00:00 [accepted] PHST- 2015/03/03 06:00 [entrez] PHST- 2015/03/03 06:00 [pubmed] PHST- 2016/12/15 06:00 [medline] AID - 10.1111/psyp.12419 [doi] PST - ppublish SO - Psychophysiology. 2015 Jul;52(7):951-6. doi: 10.1111/psyp.12419. Epub 2015 Feb 25. PMID- 12222638 OWN - NLM STAT- MEDLINE DCOM- 20021112 LR - 20190906 IS - 0168-1605 (Print) IS - 0168-1605 (Linking) VI - 78 IP - 1-2 DP - 2002 Sep 15 TI - Physiological and mathematical aspects in setting criteria for decontamination of foods by physical means. PG - 57-77 AB - In heat processing, microbial inactivation is traditionally described as log-linear. As a general rule, the relation between rate of inactivation and temperature is also described as a log-linear relation. The model is also sometimes applied in pressure and in pulsed electric field (PEF) processing. The model has proven its value by the excellent safety record of the last 80 years, but there are many deviations from log-linearity. This could lead to either over-processing or under-processing resulting in safety problems or, more likely, spoilage problems. As there is a need for minimal processing, accurate information of the inactivation kinetics is badly needed. To predict inactivation more precisely, models have been developed that can cope with deviations of linearity. As extremely low probabilities of survival must be predicted, extrapolation is almost always necessary. However, extrapolation is hardly possible without knowledge of the nature of nonlinearity. Therefore, knowledge of the physiology of inactivation is necessary. This paper discusses the physiology of denaturation by heat, high pressure and pulse electric field. After discussion of the physiological aspects, the various aspects of the development of inactivation models will be addressed. Both general and more specific aspects are discussed such as choice of test strains, effect of the culture conditions, conditions during processing and recovery conditions and mathematical modelling of inactivation. In addition to lethal inactivation, attention will be paid to sublethal inactivation because of its relevance to food preservation. Finally, the principles of quantitative microbiological risk assessment are briefly mentioned to show how appropriate inactivation criteria can be set. FAU - Smelt, Jan P P M AU - Smelt JP AD - University of Utrecht, The Netherlands. j.smelt@bio.uu.nl FAU - Hellemons, Johan C AU - Hellemons JC FAU - Wouters, Patrick C AU - Wouters PC FAU - van Gerwen, Suzanne J C AU - van Gerwen SJ LA - eng PT - Journal Article PT - Review PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM MH - Bacteria/*growth & development MH - Bacterial Physiological Phenomena MH - Consumer Product Safety MH - Decontamination/methods MH - Electric Stimulation MH - Food Contamination/prevention & control MH - Food Handling/*methods MH - Food Microbiology MH - Food Preservation/*methods MH - Food-Processing Industry MH - Hot Temperature MH - Kinetics MH - Mathematics MH - *Models, Biological MH - Pressure MH - Risk Assessment RF - 164 EDAT- 2002/09/12 10:00 MHDA- 2002/11/26 04:00 CRDT- 2002/09/12 10:00 PHST- 2002/09/12 10:00 [pubmed] PHST- 2002/11/26 04:00 [medline] PHST- 2002/09/12 10:00 [entrez] AID - S0168-1605(02)00242-8 [pii] AID - 10.1016/s0168-1605(02)00242-8 [doi] PST - ppublish SO - Int J Food Microbiol. 2002 Sep 15;78(1-2):57-77. doi: 10.1016/s0168-1605(02)00242-8. PMID- 39071942 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240730 IS - 2666-6758 (Electronic) IS - 2666-6758 (Linking) VI - 5 IP - 4 DP - 2024 Jul 1 TI - The extremotolerant desert moss Syntrichia caninervis is a promising pioneer plant for colonizing extraterrestrial environments. PG - 100657 LID - 10.1016/j.xinn.2024.100657 [doi] LID - 100657 AB - Many plans to establish human settlements on other planets focus on adapting crops to growth in controlled environments. However, these settlements will also require pioneer plants that can grow in the soils and harsh conditions found in extraterrestrial environments, such as those on Mars. Here, we report the extraordinary environmental resilience of Syntrichia caninervis, a desert moss that thrives in various extreme environments. S. caninervis has remarkable desiccation tolerance; even after losing >98% of its cellular water content, it can recover photosynthetic and physiological activities within seconds after rehydration. Intact plants can tolerate ultra-low temperatures and regenerate even after being stored in a freezer at -80°C for 5 years or in liquid nitrogen for 1 month. S. caninervis also has super-resistance to gamma irradiation and can survive and maintain vitality in simulated Mars conditions; i.e., when simultaneously exposed to an anoxic atmosphere, extreme desiccation, low temperatures, and intense UV radiation. Our study shows that S. caninervis is among the most stress tolerant organisms. This work provides fundamental insights into the multi-stress tolerance of the desert moss S. caninervis, a promising candidate pioneer plant for colonizing extraterrestrial environments, laying the foundation for building biologically sustainable human habitats beyond Earth. CI - © 2024 Published by Elsevier Inc. on behalf of Youth Innovation Co., Ltd. FAU - Li, Xiaoshuang AU - Li X AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. FAU - Bai, Wenwan AU - Bai W AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Yang, Qilin AU - Yang Q AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. AD - University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Yin, Benfeng AU - Yin B AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. FAU - Zhang, Zhenlong AU - Zhang Z AD - National Space Science Center, Chinese Academy of Sciences, Beijing 100190, China. FAU - Zhao, Banchi AU - Zhao B AD - National Space Science Center, Chinese Academy of Sciences, Beijing 100190, China. FAU - Kuang, Tingyun AU - Kuang T AD - Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China. FAU - Zhang, Yuanming AU - Zhang Y AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. FAU - Zhang, Daoyuan AU - Zhang D AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. LA - eng PT - Journal Article DEP - 20240630 PL - United States TA - Innovation (Camb) JT - Innovation (Cambridge (Mass.)) JID - 101771342 PMC - PMC11282406 COIS- The authors declare no competing interest. EDAT- 2024/07/29 06:42 MHDA- 2024/07/29 06:43 PMCR- 2024/06/30 CRDT- 2024/07/29 05:51 PHST- 2024/04/16 00:00 [received] PHST- 2024/06/08 00:00 [accepted] PHST- 2024/07/29 06:43 [medline] PHST- 2024/07/29 06:42 [pubmed] PHST- 2024/07/29 05:51 [entrez] PHST- 2024/06/30 00:00 [pmc-release] AID - S2666-6758(24)00095-X [pii] AID - 100657 [pii] AID - 10.1016/j.xinn.2024.100657 [doi] PST - epublish SO - Innovation (Camb). 2024 Jun 30;5(4):100657. doi: 10.1016/j.xinn.2024.100657. eCollection 2024 Jul 1. PMID- 34198424 OWN - NLM STAT- MEDLINE DCOM- 20210802 LR - 20220531 IS - 1551-0018 (Electronic) IS - 1547-1063 (Linking) VI - 18 IP - 4 DP - 2021 May 10 TI - Durability evaluation of highway tunnel lining structure based on matter element extension-simple correlation function method-cloud model: A case study. PG - 4027-4054 LID - 10.3934/mbe.2021202 [doi] AB - With the acceleration of infrastructure construction in various countries, more and more highway tunnels have been built. As a permanent structure to maintain the long-term stability and durability of the tunnel, the tunnel lining structure (TLS) is prone to durability damage in the later operation process, which affects the safety of traffic and the whole loading capacity of the tunnel, so it is very important to evaluate the durability of the TLS. Nowadays, the TLS durability evaluation methods ignore the ambiguity and randomness of the lining structure (LS) durability evaluation index, which have certain limitations. In order to evaluate the durability of highway TLS scientifically and rationally, this paper proposes a method for evaluating the durability of highway TLS based on the matter-element extension (MEE)- simple correlation function (SCF) method- cloud model (CM). A case study was carried out by combining the advantages of the above three methods, a LS durability evaluation model was established, and based on the relevant data from the actual inspection of a highway tunnel lining durability disease in China, the model was used to evaluate the durability of the lining of this highway tunnel, and the durability grades were equivalently divided into five grades: in good shape(I), slightly damaged(II), medium damaged(III), severely damaged(IV), extremely dangerous(V). The result show that this tunnel lining belongs to IV, and the result of this evaluation method is in accordance with the actual damage condition of the project, and the accuracy reaches 92.75%. At the same time, a comparative study was carried out in combination with the AHP-Extenics to verify the reasonableness and feasibility of this method. This study provides a new method for durability evaluation of LS, offers a theory basis for judging the durability of highway TLS, and lays a foundation for subsequent maintenance and prevention. FAU - Li, Qingfu AU - Li Q AD - School of Water Conservancy Engineering, Zhengzhou University, No. 100, Science Avenue, Zhengzhou 450001, China. FAU - Zhou, Huade AU - Zhou H AD - School of Water Conservancy Engineering, Zhengzhou University, No. 100, Science Avenue, Zhengzhou 450001, China. FAU - Zhang, Hua AU - Zhang H AD - School of Water Conservancy Engineering, Zhengzhou University, No. 100, Science Avenue, Zhengzhou 450001, China. LA - eng PT - Journal Article PL - United States TA - Math Biosci Eng JT - Mathematical biosciences and engineering : MBE JID - 101197794 SB - IM MH - China MH - *Construction Industry MH - *Construction Materials OTO - NOTNLM OT - Analytic Hierarchy Process (AHP) OT - Extenics OT - cloud model OT - durability evaluation OT - lining structure OT - matter element extension OT - simple correlation function OT - tunnel EDAT- 2021/07/03 06:00 MHDA- 2021/08/03 06:00 CRDT- 2021/07/02 01:00 PHST- 2021/07/02 01:00 [entrez] PHST- 2021/07/03 06:00 [pubmed] PHST- 2021/08/03 06:00 [medline] AID - 10.3934/mbe.2021202 [doi] PST - ppublish SO - Math Biosci Eng. 2021 May 10;18(4):4027-4054. doi: 10.3934/mbe.2021202. PMID- 6880868 OWN - NLM STAT- MEDLINE DCOM- 19830909 LR - 20110107 IS - 0065-1400 (Print) IS - 0065-1400 (Linking) VI - 43 IP - 1 DP - 1983 TI - The effect of instrumentalization of inborn reaction on its transformation into contrary directed escape response in dogs and the problem of reinforcement. PG - 1-14 AB - Transformation of inborn reaction of leg flexion into conditioned escape response of leg extension was studied. The model of the so called precise reflex was used. A dog could avoid or escape the shock applied to the paw by placing this paw in a narrow ,,safety zone located at a definite height above the floor. When the shock is applied to the paw located below this zone, the escape response is flexion, i.e., it coincides with the inborn reaction. When the paw is lifted above this zone, the escape response is extension, i.e., it is opposite to the inborn response. Success of such extension response acquisition depended on the sequence of training conditions. The dogs of Group I at the beginning were accustomed to escape from shock by lifting the paw into the ,,safety zone, i.e., inborn reaction was instrumentalized. A subsequent formation of conditioned extension was extremely difficult and it did not became strong in spite of a very long training. Lowering the paw into the ,,safety zone was usually slow. The dogs of group II were trained from the very beginning to escape from shock by leg extension. Contrary to the results obtained on group I this conditioned response was perfectly established. It was formed rapidly, only when active extension was paired regularly with termination (during extension) of the shock. It is suggested that conditioned connection from one functional center to another is formed and becomes stronger if evoked activity of the first center decreases during (or immediately after) the excitation of the second center. FAU - Frolov, A G AU - Frolov AG LA - eng PT - Journal Article PL - Poland TA - Acta Neurobiol Exp (Wars) JT - Acta neurobiologiae experimentalis JID - 1246675 SB - IM MH - Animals MH - *Conditioning, Operant MH - Dogs MH - Electroshock MH - *Escape Reaction MH - *Instinct MH - Muscle Contraction MH - Reflex EDAT- 1983/01/01 00:00 MHDA- 1983/01/01 00:01 CRDT- 1983/01/01 00:00 PHST- 1983/01/01 00:00 [pubmed] PHST- 1983/01/01 00:01 [medline] PHST- 1983/01/01 00:00 [entrez] PST - ppublish SO - Acta Neurobiol Exp (Wars). 1983;43(1):1-14. PMID- 2734808 OWN - NLM STAT- MEDLINE DCOM- 19890725 LR - 20190819 IS - 0300-483X (Print) IS - 0300-483X (Linking) VI - 56 IP - 3 DP - 1989 Jun 16 TI - Resistance of Drosophila to cadmium: biochemical factors in resistant and sensitive strains. PG - 315-21 AB - With regard to cadmium toxicity, Drosophila strains v;bw and Austin represent extremes in resistance and sensitivity, respectively. Both strains produced metallothionein (MT) in response to Cd ions in their diet. Austin produced more metallothionein than v;bw at Cd ion levels below 0.2 mM, when both strains were allowed lifetime development on Cd2+-containing media. When the rate of MT appearance was measured for 4 days in young adults the results showed no clear trend with time within a strain or between strains. The plot of LC50 vs. MT levels for identical developmental conditions revealed that for v;bw small increases in MT corresponded to large increases in resistance whereas for the sensitive Austin even large increases in MT had comparatively little effect on increasing LC50. Results given here suggest that differences in total MT content do not explain the genetically demonstrable difference in Cd2+-resistance between v;bw and Austin. However, since two MT genes are identified in Drosophila, differences in resistance could be reflective of greater relative amounts of one "more important" MT in the resistant fly. FAU - Gill, H J AU - Gill HJ AD - Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831. FAU - Nida, D L AU - Nida DL FAU - Dean, D A AU - Dean DA FAU - England, M W AU - England MW FAU - Jacobson, K B AU - Jacobson KB LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. PL - Ireland TA - Toxicology JT - Toxicology JID - 0361055 RN - 00BH33GNGH (Cadmium) RN - 9038-94-2 (Metallothionein) SB - IM MH - Animals MH - Cadmium/*toxicity MH - Chromatography, Gel MH - Chromatography, Ion Exchange MH - Drosophila/*drug effects/genetics/metabolism MH - Drug Resistance/genetics MH - Lethal Dose 50 MH - Male MH - Metallothionein/biosynthesis/*genetics MH - Species Specificity EDAT- 1989/06/16 00:00 MHDA- 1989/06/16 00:01 CRDT- 1989/06/16 00:00 PHST- 1989/06/16 00:00 [pubmed] PHST- 1989/06/16 00:01 [medline] PHST- 1989/06/16 00:00 [entrez] AID - 0300-483X(89)90094-2 [pii] AID - 10.1016/0300-483x(89)90094-2 [doi] PST - ppublish SO - Toxicology. 1989 Jun 16;56(3):315-21. doi: 10.1016/0300-483x(89)90094-2. PMID- 12131976 OWN - NLM STAT- MEDLINE DCOM- 20030203 LR - 20190605 IS - 0034-8910 (Print) IS - 0034-8910 (Linking) VI - 36 IP - 3 DP - 2002 Jun TI - [Hygienic conditions of hot dogs sold on the streets, Brazil]. PG - 350-2 AB - The study objective was to identify the circumstances where there was risk of contamination of food (hot dogs) prepared and sold on the streets and to establish a preventive action through the creation of key surveillance sites. Data were collected from 20 vending sites using interviews, questionnaires, observations of food handling and storage, and temperature and pH measurements of both meat and sauce, respectively. In 30% of the studied sites, hygienic conditions were rated as regular to extremely poor. Mashed potatoes, chicken and beef preparations were of high risk. These findings showed inappropriate hygienic practices of food preparation and lack of basic knowledge regarding food handling - a public health problem. Given the scarcity of literature and official data on food sold in the streets of Brazil, further studies are recommended. FAU - Lucca, Alessandra AU - Lucca A AD - Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil. FAU - Torres, Elizabeth Aparecida F S AU - Torres EA LA - por PT - English Abstract PT - Journal Article TT - Condições de higiene de "cachorro-quente" comercializado em vias públicas. PL - Brazil TA - Rev Saude Publica JT - Revista de saude publica JID - 0135043 SB - IM MH - Brazil MH - *Commerce MH - Consumer Product Safety MH - Food Contamination/prevention & control MH - Food Handling/*standards MH - *Hygiene MH - *Meat Products MH - Risk Factors EDAT- 2002/07/20 10:00 MHDA- 2003/02/04 04:00 CRDT- 2002/07/20 10:00 PHST- 2002/07/20 10:00 [pubmed] PHST- 2003/02/04 04:00 [medline] PHST- 2002/07/20 10:00 [entrez] AID - S0034-89102002000300015 [pii] AID - 10.1590/s0034-89102002000300015 [doi] PST - ppublish SO - Rev Saude Publica. 2002 Jun;36(3):350-2. doi: 10.1590/s0034-89102002000300015. PMID- 29332471 OWN - NLM STAT- MEDLINE DCOM- 20180723 LR - 20190107 IS - 1938-162X (Electronic) IS - 1062-6050 (Print) IS - 1062-6050 (Linking) VI - 53 IP - 1 DP - 2018 Jan TI - Fatal Exertional Heat Stroke and American Football Players: The Need for Regional Heat-Safety Guidelines. PG - 43-50 LID - 10.4085/1062-6050-445-16 [doi] AB - CONTEXT:   Weather-based activity modification in athletics is an important way to minimize heat illnesses. However, many commonly used heat-safety guidelines include a uniform set of heat-stress thresholds that do not account for geographic differences in acclimatization. OBJECTIVE:   To determine if heat-related fatalities among American football players occurred on days with unusually stressful weather conditions based on the local climate and to assess the need for regional heat-safety guidelines. DESIGN:   Cross-sectional study. SETTING:   Data from incidents of fatal exertional heat stroke (EHS) in American football players were obtained from the National Center for Catastrophic Sport Injury Research and the Korey Stringer Institute. PATIENTS OR OTHER PARTICIPANTS:   Sixty-one American football players at all levels of competition with fatal EHSs from 1980 to 2014. MAIN OUTCOME MEASURE(S):   We used the wet bulb globe temperature (WBGT) and a z-score WBGT standardized to local climate conditions from 1991 to 2010 to assess the absolute and relative magnitudes of heat stress, respectively. RESULTS:   We observed a poleward decrease in exposure WBGTs during fatal EHSs. In milder climates, 80% of cases occurred at above-average WBGTs, and 50% occurred at WBGTs greater than 1 standard deviation from the long-term mean; however, in hotter climates, half of the cases occurred at near average or below average WBGTs. CONCLUSIONS:   The combination of lower exposure WBGTs and frequent extreme climatic values in milder climates during fatal EHSs indicates the need for regional activity-modification guidelines with lower, climatically appropriate weather-based thresholds. Established activity-modification guidelines, such as those from the American College of Sports Medicine, work well in the hotter climates, such as the southern United States, where hot and humid weather conditions are common. FAU - Grundstein, Andrew J AU - Grundstein AJ AD - Department of Geography, University of Georgia, Athens. FAU - Hosokawa, Yuri AU - Hosokawa Y AD - Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs. FAU - Casa, Douglas J AU - Casa DJ AD - Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20180113 PL - United States TA - J Athl Train JT - Journal of athletic training JID - 9301647 SB - IM MH - Acclimatization/*physiology MH - Adult MH - Cross-Sectional Studies MH - Football/*injuries MH - *Guidelines as Topic MH - Heat Stroke/epidemiology/*prevention & control MH - Hot Temperature/*adverse effects MH - Humans MH - Incidence MH - Male MH - Primary Prevention/*standards MH - Survival Rate/trends MH - United States/epidemiology MH - *Universities PMC - PMC5800727 OTO - NOTNLM OT - acclimatization OT - exertional heat illness OT - wet bulb globe temperature EDAT- 2018/01/16 06:00 MHDA- 2018/07/24 06:00 PMCR- 2019/01/01 CRDT- 2018/01/16 06:00 PHST- 2018/01/16 06:00 [pubmed] PHST- 2018/07/24 06:00 [medline] PHST- 2018/01/16 06:00 [entrez] PHST- 2019/01/01 00:00 [pmc-release] AID - 10.4085/1062-6050-445-16 [doi] PST - ppublish SO - J Athl Train. 2018 Jan;53(1):43-50. doi: 10.4085/1062-6050-445-16. Epub 2018 Jan 13. PMID- 33501175 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210127 IS - 2296-9144 (Electronic) IS - 2296-9144 (Linking) VI - 7 DP - 2020 TI - Radiation Tolerance Testing Methodology of Robotic Manipulator Prior to Nuclear Waste Handling. PG - 6 LID - 10.3389/frobt.2020.00006 [doi] LID - 6 AB - Dramatic cost savings, safety improvements and accelerated nuclear decommissioning are all possible through the application of robotic solutions. Remotely-controlled systems with modern sensing capabilities, actuators and cutting tools have the potential for use in extremely hazardous environments, but operation in facilities used for handling radioactive material presents complex challenges for electronic components. We present a methodology and results obtained from testing in a radiation cell in which we demonstrate the operation of a robotic arm controlled using modern electronics exposed at 10 Gy/h to simulate radioactive conditions in the most hazardous nuclear waste handling facilities. CI - Copyright © 2020 Zhang, Hutson, Knighton, Herrmann and Scott. FAU - Zhang, Kaiqiang AU - Zhang K AD - Department of Mechanical Engineering, University of Bristol, University Walk, Bristol, United Kingdom. FAU - Hutson, Chris AU - Hutson C AD - H.H. Wills Physics Laboratory, University of Bristol, Bristol, United Kingdom. FAU - Knighton, James AU - Knighton J AD - H.H. Wills Physics Laboratory, University of Bristol, Bristol, United Kingdom. FAU - Herrmann, Guido AU - Herrmann G AD - Department of Electrical and Electronic Engineering, University of Manchester, Manchester, United Kingdom. FAU - Scott, Tom AU - Scott T AD - H.H. Wills Physics Laboratory, University of Bristol, Bristol, United Kingdom. LA - eng PT - Journal Article DEP - 20200206 PL - Switzerland TA - Front Robot AI JT - Frontiers in robotics and AI JID - 101749350 PMC - PMC7805772 OTO - NOTNLM OT - exposure OT - gamma OT - manipulator OT - radiation OT - radioactive OT - robot OT - tolerance OT - waste EDAT- 2021/01/28 06:00 MHDA- 2021/01/28 06:01 PMCR- 2020/02/06 CRDT- 2021/01/27 05:53 PHST- 2019/09/18 00:00 [received] PHST- 2020/01/15 00:00 [accepted] PHST- 2021/01/27 05:53 [entrez] PHST- 2021/01/28 06:00 [pubmed] PHST- 2021/01/28 06:01 [medline] PHST- 2020/02/06 00:00 [pmc-release] AID - 10.3389/frobt.2020.00006 [doi] PST - epublish SO - Front Robot AI. 2020 Feb 6;7:6. doi: 10.3389/frobt.2020.00006. eCollection 2020. PMID- 25996778 OWN - NLM STAT- MEDLINE DCOM- 20160427 LR - 20150730 IS - 1557-8542 (Electronic) IS - 1545-8547 (Linking) VI - 12 IP - 4 DP - 2015 Aug TI - Acute and Chronic Toxicity of Nitrate to Early Life Stages of Zebrafish--Setting Nitrate Safety Levels for Zebrafish Rearing. PG - 305-11 AB - Recirculating aquaculture systems (RAS) have been widely used for zebrafish rearing, allowing holding of many thousands of fish at high densities. Water quality in RAS largely depends on biofilters that ultimately convert the extremely toxic ammonia excreted by fish into the much less toxic nitrate. However, when water renewal is minimal in RAS, nitrate can accumulate to high enough levels to negatively impact fish welfare and performance. Therefore, the setting of safety levels of nitrate for zebrafish should be a priority to avoid unwanted effects in both the intensive production of this species and research outputs. The present study aimed to define nitrate safety levels for zebrafish based on acute and chronic toxicity bioassays in early life stages of this species. Acute bioassays revealed ontogenetic changes in response to high nitrate levels. Based on NOEC (no observed effect concentration) values, safety levels should be set at 1450, 1855, and 1075 mg/L NO3(-)-N to prevent acute lethal effects in embryos, newly-hatched larvae, and swim-up larvae, respectively. In the chronic bioassay, larvae were exposed to nitrate concentrations of 50, 100, 200, and 400 mg/L NO3(-)-N during the entire larval period (23 days). No negative effects were observed either on larval performance or condition at concentrations up to 200 mg/L NO3(-)-N. However, at 400 mg/L NO3(-)-N, survival drastically decreased and fish showed reduced growth and evidence of morphological abnormalities. Accordingly, a safety level of 200 mg/L NO3(-)-N is recommended during the larval rearing of zebrafish to prevent negative impacts on juvenile production. FAU - Learmonth, Cândida AU - Learmonth C AD - 1 Department of Biology, Faculty of Sciences, University of Porto , Porto, Portugal . FAU - Carvalho, António Paulo AU - Carvalho AP AD - 1 Department of Biology, Faculty of Sciences, University of Porto , Porto, Portugal . AD - 2 CIIMAR/CIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto , Porto, Portugal . LA - eng PT - Journal Article DEP - 20150521 PL - United States TA - Zebrafish JT - Zebrafish JID - 101225070 RN - 0 (Nitrates) RN - 0 (Water Pollutants, Chemical) SB - IM MH - Animals MH - Aquaculture MH - Nitrates/*toxicity MH - Random Allocation MH - Water Pollutants, Chemical/*toxicity MH - Zebrafish/growth & development/*metabolism EDAT- 2015/05/23 06:00 MHDA- 2016/04/28 06:00 CRDT- 2015/05/22 06:00 PHST- 2015/05/22 06:00 [entrez] PHST- 2015/05/23 06:00 [pubmed] PHST- 2016/04/28 06:00 [medline] AID - 10.1089/zeb.2015.1098 [pii] AID - 10.1089/zeb.2015.1098 [doi] PST - ppublish SO - Zebrafish. 2015 Aug;12(4):305-11. doi: 10.1089/zeb.2015.1098. Epub 2015 May 21. PMID- 19887168 OWN - NLM STAT- MEDLINE DCOM- 20100125 LR - 20220316 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 42 IP - 1 DP - 2010 Jan TI - Determinants behind young motorcyclists' risky riding behavior. PG - 275-81 LID - 10.1016/j.aap.2009.08.004 [doi] AB - Young motorcyclists have traditionally been considered a high-risk population. Given the critical influence of riders' behaviors on traffic safety, identifying what riders think can help clarify the nature of accidents. Although psychological studies have explored the relationships among personality traits, attitudes and risky driving behavior, the primary difference this study makes from past studies is incorporating both positive and negative effects in a refined causal framework. This study adopts structural equation modeling to analyze data collected from 683 young motorcyclists aged between 18 and 28. The results conclude three primary personality traits of young motorcyclists, namely sensation seeking, amiability and impatience. While amiable riders represent a group of relatively mature and safe riders, the sensation-seeking riders are extremely self-confident, comfortable with unsafe riding and interested in the utility gained from it. Meanwhile, the sensation-seeking ones also are highly aware of traffic conditions, which may lower the chances of getting into an accident, but the accident could be extremely severe if it ever occurs. Impatient riders, having low riding confidence and traffic awareness deficiency, also seek utility from certain risky riding behaviors. However, their fear of an accident leads them to fail to observe surrounding traffic conditions. The result indicates various mental compromise mechanisms for young motorcyclists in conducting riding behaviors. Thus, corresponding countermeasures, including licensure system and ITS roadway development, should consider the heterogeneous characteristics of young riders. FAU - Wong, Jinn-Tsai AU - Wong JT AD - Institute of Traffic and Transportation, National Chiao Tung University, 4F, 118 Chung Hsiao W. Rd., Sec. 1, Taipei 10044, Taiwan. jtwong@mail.nctu.edu.tw FAU - Chung, Yi-Shih AU - Chung YS FAU - Huang, Shih-Hsuan AU - Huang SH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090828 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Adolescent MH - Adult MH - Anger MH - Factor Analysis, Statistical MH - Humans MH - *Motorcycles/statistics & numerical data MH - *Personality MH - *Risk-Taking MH - Temperament MH - Young Adult EDAT- 2009/11/06 06:00 MHDA- 2010/01/26 06:00 CRDT- 2009/11/06 06:00 PHST- 2009/02/14 00:00 [received] PHST- 2009/07/22 00:00 [revised] PHST- 2009/08/04 00:00 [accepted] PHST- 2009/11/06 06:00 [entrez] PHST- 2009/11/06 06:00 [pubmed] PHST- 2010/01/26 06:00 [medline] AID - S0001-4575(09)00212-7 [pii] AID - 10.1016/j.aap.2009.08.004 [doi] PST - ppublish SO - Accid Anal Prev. 2010 Jan;42(1):275-81. doi: 10.1016/j.aap.2009.08.004. Epub 2009 Aug 28. PMID- 23905594 OWN - NLM STAT- MEDLINE DCOM- 20141117 LR - 20191027 IS - 1875-6212 (Electronic) IS - 1570-1611 (Linking) VI - 12 IP - 1 DP - 2014 Jan TI - Renal nerve ablation for hypertensive patients with chronic kidney disease. PG - 47-54 AB - Among current epidemics, chronic kidney disease (CKD) is accompanied with high morbidity and mortality rates inherently associated with the thriving comorbidities of hypertension and cardiovascular disease. In this mutually reinforcing triad, adequate control of high blood pressure emerges as extremely important for decreasing patients' complication rates and prolonging life expectancy. However, hypertension control in this particular group of patients is often proven an arduous task, presenting high rates of resistance. Sympathetic nervous system (SNS) overactivity is implicated not only in the pathophysiological basis of difficult-to-treat hypertension, but also in the development and progression of renal disease, thus rendering SNS a prime therapeutic target in CKD. As renal nerve ablation (RNA) is finding its place among other invasive procedures in the cardiovascular arena, the potential therapeutic impact of this innovative treatment modality is gradually expanding from resistant hypertension to other high blood pressure-related clinical conditions like CKD. Encouraging results of clinical trials testing efficacy and safety of renal nerve ablation in resistant hypertensives provide the opportunity to apply the procedure in other subgroups of hypertensive patients. Available data regarding renal function of study participants suggest the safe implementation of RNA in patients with renal disease, but both unexplored benefits as well as potential hazards should be taken into account and critically evaluated. While renal denervation has been tested in selected cases of patients with renal disease, the results of large, multicenter trials evaluating the effects of this procedure on large cohorts of patients with CKD are eagerly anticipated. FAU - Papademetriou, V AU - Papademetriou V FAU - Doumas, M AU - Doumas M FAU - Anyfanti, P AU - Anyfanti P FAU - Faselis, C AU - Faselis C FAU - Kokkinos, P AU - Kokkinos P FAU - Tsioufis, C AU - Tsioufis C AD - VA Medical Center, 50 Irving Street, NW, Washington, DC 20422. vpapademetriou@va.gov. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Vasc Pharmacol JT - Current vascular pharmacology JID - 101157208 SB - IM MH - Blood Pressure/physiology MH - Catheter Ablation/instrumentation/*methods MH - Humans MH - Hypertension/complications/physiopathology/*surgery MH - Kidney/*innervation MH - Renal Insufficiency, Chronic/complications/physiopathology/*surgery MH - Sympathectomy/instrumentation/*methods MH - Sympathetic Nervous System/*physiopathology EDAT- 2013/08/03 06:00 MHDA- 2014/11/18 06:00 CRDT- 2013/08/03 06:00 PHST- 2012/05/31 00:00 [received] PHST- 2012/09/17 00:00 [revised] PHST- 2013/02/27 00:00 [accepted] PHST- 2013/08/03 06:00 [entrez] PHST- 2013/08/03 06:00 [pubmed] PHST- 2014/11/18 06:00 [medline] AID - 54750 [pii] AID - 10.2174/15701611113119990143 [doi] PST - ppublish SO - Curr Vasc Pharmacol. 2014 Jan;12(1):47-54. doi: 10.2174/15701611113119990143. PMID- 32172050 OWN - NLM STAT- MEDLINE DCOM- 20200625 LR - 20200625 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 319 DP - 2020 Jul 30 TI - Influence of extreme alkaline pH induced unfolding and aggregation on PSE-like chicken protein edible film formation. PG - 126574 LID - S0308-8146(20)30436-2 [pii] LID - 10.1016/j.foodchem.2020.126574 [doi] AB - The mechanisms of the unfolding and aggregation of PSE-like chicken meat protein at extreme alkaline pHs (pH 11.0, 11.5 and 12.0) were studied and related to the physical properties of edible films. Results of asymmetrical flow field-flow fractionation coupled with various detectors showed that pH 12.0 leads to a certain degree of protein aggregation, which could also be observed in atomic force microscopy (AFM) images. Higher levels of protein denaturation and unfolding, as proved by the circular dichroism spectrum, could result in aggregates formation, whereas all pH-adjusted groups exhibited similar flow behavior. The pH 11.0 sample exhibited films with higher water resistance compared to others. Comparatively, solubilizing PSE-like meat protein at pH 11.5 could result in better edible films with greater mechanical properties, water resistance and transparency. Our results elucidated the effects of the PSE-like chicken meat protein unfolding and aggregation on edible film properties under various extreme alkaline pH conditions. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Zhao, Xue AU - Zhao X AD - Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Key Laboratory of Animal Products Processing, MOA, Key Lab of Meat Processing and Quality Control, MOE, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. FAU - Xing, Tong AU - Xing T AD - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. FAU - Xu, Xinglian AU - Xu X AD - Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Key Laboratory of Animal Products Processing, MOA, Key Lab of Meat Processing and Quality Control, MOE, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: xlxus@njau.edu.cn. FAU - Zhou, Guanghongo AU - Zhou G AD - Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Key Laboratory of Animal Products Processing, MOA, Key Lab of Meat Processing and Quality Control, MOE, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. LA - eng PT - Journal Article DEP - 20200306 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Avian Proteins) SB - IM MH - Animals MH - Avian Proteins/*chemistry MH - *Chickens MH - *Edible Films MH - Hydrogen-Ion Concentration MH - Microscopy, Atomic Force MH - Protein Biosynthesis MH - Protein Denaturation MH - Protein Unfolding OTO - NOTNLM OT - Asymmetrical flow field-flow fractionation OT - Edible film OT - PSE-like meat OT - Protein aggregation COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/03/17 06:00 MHDA- 2020/06/26 06:00 CRDT- 2020/03/16 06:00 PHST- 2019/09/16 00:00 [received] PHST- 2020/02/14 00:00 [revised] PHST- 2020/03/05 00:00 [accepted] PHST- 2020/03/17 06:00 [pubmed] PHST- 2020/06/26 06:00 [medline] PHST- 2020/03/16 06:00 [entrez] AID - S0308-8146(20)30436-2 [pii] AID - 10.1016/j.foodchem.2020.126574 [doi] PST - ppublish SO - Food Chem. 2020 Jul 30;319:126574. doi: 10.1016/j.foodchem.2020.126574. Epub 2020 Mar 6. PMID- 28546646 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 0022-3433 (Print) IS - 0022-3433 (Linking) VI - 54 IP - 2 DP - 2017 Mar TI - Canaries in a coal-mine? What the killings of journalists tell us about future repression. PG - 157-174 LID - 10.1177/0022343316680859 [doi] AB - An independent press that is free from government censorship is regarded as instrumental to ensuring human rights protection. Yet governments across the globe often target journalists when their reports seem to offend them or contradict their policies. Can the government's infringements of the rights of journalists tell us anything about its wider human rights agenda? The killing of a journalist is a sign of deteriorating respect for human rights. If a government orders the killing of a journalist, it is willing to use extreme measures to eliminate the threat posed by the uncontrolled flow of information. If non-state actors murder journalists, it reflects insecurity, which can lead to a backlash by the government, again triggering state-sponsored repression. To test the argument whether the killing of journalists is a precursor to increasing repression, we introduce a new global dataset on killings of journalists between 2002 and 2013 that uses three different sources that track such events across the world. The new data show that mostly local journalists are targeted and that in most cases the perpetrators remain unconfirmed. Particularly in countries with limited repression, human rights conditions are likely to deteriorate in the two years following the killing of a journalist. When journalists are killed, human rights conditions are unlikely to improve where standard models of human rights would expect an improvement. Our research underlines the importance of taking the treatment of journalists seriously, not only because failure to do so endangers their lives and limits our understanding of events on the ground, but also because their physical safety is an important precursor of more repression in the future. FAU - Gohdes, Anita R AU - Gohdes AR AD - Department of Political Science, University of Zurich. FAU - Carey, Sabine C AU - Carey SC AD - School of Social Sciences, University of Mannheim. LA - eng PT - Journal Article DEP - 20170101 PL - England TA - J Peace Res JT - Journal of peace research JID - 100967901 PMC - PMC5427995 OTO - NOTNLM OT - human rights OT - journalists OT - political violence OT - press freedom OT - repression EDAT- 2017/05/27 06:00 MHDA- 2017/05/27 06:01 PMCR- 2017/05/12 CRDT- 2017/05/27 06:00 PHST- 2017/05/27 06:00 [entrez] PHST- 2017/05/27 06:00 [pubmed] PHST- 2017/05/27 06:01 [medline] PHST- 2017/05/12 00:00 [pmc-release] AID - 10.1177_0022343316680859 [pii] AID - 10.1177/0022343316680859 [doi] PST - ppublish SO - J Peace Res. 2017 Mar;54(2):157-174. doi: 10.1177/0022343316680859. Epub 2017 Jan 1. PMID- 11339702 OWN - NLM STAT- MEDLINE DCOM- 20010906 LR - 20191104 IS - 0167-6369 (Print) IS - 0167-6369 (Linking) VI - 67 IP - 1-2 DP - 2001 Feb-Mar TI - Modeling the hydroclimatic disturbance of soil landscapes in the southern Canadian plains: the problems of scale and place. PG - 277-91 AB - The sensitivity of soil landscapes to climatic variability and hydroclimatic events can be expressed as a landscape change safety factor, the ratio of potential disturbance to resistance to change. The use of a geographic information system (GIS) enables the spatially-explicit modeling of landscape sensitivity, but also raises the risk of violating the characteristic scales of disturbance and resistance, because the GIS technically simplifies the extrapolation of models, and associated concepts, to landscapes and scales not represented by the digital data base. Embedding landscape sensitivity into hierarchy theory, the formal analysis of the hierarchical structure of complex systems, provides a conceptual framework for the transfer of models and variables among landscape scales. In the subhumid southern Canadian plains, major hydroclimatic events (strong winds, intense rain, rapid snow melt) cause much of the physical disturbance of soil landscapes and terrestrial ecosystems. Prolonged dry or wet weather influences the resistance of soil and vegetation to these events. The potential disturbance of soil landscapes therefore can be derived from the probabilities of extreme events and seasonal conditions, as recorded in instrumental and proxy climate records. This time series analysis can be linked to the modeling of landscape sensitivity by establishing the probabilities of hydroclimatic events and climatic conditions which may exceed or lower the resistance of individual soil landscapes. FAU - Sauchyn, D J AU - Sauchyn DJ AD - Department of Geography, University of Regina, Saskatchewan, Canada. sauchyn@uregina.ca LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 0 (Soil) SB - IM MH - Canada MH - *Climate MH - Ecosystem MH - Forecasting MH - Geological Phenomena MH - Geology MH - *Models, Theoretical MH - Soil MH - *Water Movements EDAT- 2001/05/08 10:00 MHDA- 2001/09/08 10:01 CRDT- 2001/05/08 10:00 PHST- 2001/05/08 10:00 [pubmed] PHST- 2001/09/08 10:01 [medline] PHST- 2001/05/08 10:00 [entrez] AID - 10.1023/a:1006442824787 [doi] PST - ppublish SO - Environ Monit Assess. 2001 Feb-Mar;67(1-2):277-91. doi: 10.1023/a:1006442824787. PMID- 33472856 OWN - NLM STAT- MEDLINE DCOM- 20211215 LR - 20211215 IS - 2051-1426 (Electronic) IS - 2051-1426 (Linking) VI - 9 IP - 1 DP - 2021 Jan TI - Tisagenlecleucel infusion in patients with relapsed/refractory ALL and concurrent serious infection. LID - 10.1136/jitc-2020-001225 [doi] LID - e001225 AB - BACKGROUND: Tisagenlecleucel, an anti-CD19 chimeric antigen receptor T (CAR-T) cell therapy, has demonstrated durable efficacy and a manageable safety profile in pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) in the ELIANA pivotal trial and real-world experience. Experience from investigator-led studies prior to ELIANA suggests that infections and inflammatory conditions may exacerbate the severity of cytokine release syndrome (CRS) associated with CAR-T cell therapy, leading to extreme caution and strong restrictions for on-study and commercial infusion of tisagenlecleucel in patients with active infection. CRS intervention with interleukin (IL)-6 blockade and/or steroid therapy was introduced late in the course during clinical trials due to concern for potential negative effect on efficacy and persistence. However, earlier CRS intervention is now viewed more favorably. Earlier intervention and consistency in management between providers may promote broader use of tisagenlecleucel, including potential curative therapy in patients who require remission and recovery of hematopoiesis for management of severe infection. MAIN BODY: Patient 1 was diagnosed with B-ALL at 23 years old. Fourteen days before tisagenlecleucel infusion, the patient developed fever and neutropenia and was diagnosed with invasive Mucorales infection and BK virus hemorrhagic cystitis. Aggressive measures were instituted to control infection and to manage prolonged cytopenias during CAR-T cell manufacturing. Adverse events, including CRS, were manageable despite elevated inflammatory markers and active infection. The patient attained remission and recovered hematopoiesis, and infections resolved. The patient remains in remission ≥1 year postinfusion.Patient 2 was diagnosed with pre-B-ALL at preschool age. She developed severe septic shock 3 days postinitiation of lymphodepleting chemotherapy. After receiving tisagenlecleucel, she experienced CRS with cardiac dysfunction and extensive lymphadenopathy leading to renovascular compromise. The patient attained remission and was discharged in good condition to her country of origin. She remained in remission but expired on day 208 postinfusion due to cardiac arrest of unclear etiology. CONCLUSIONS: Infusion was feasible, and toxicity related to tisagenlecleucel was manageable despite active infections and concurrent inflammation, allowing attainment of remission in otherwise refractory pediatric/young adult ALL. This may lead to consideration of tisagenlecleucel as a potential curative therapy in patients with managed active infections. CI - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Hall, Erin M AU - Hall EM AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Yin, Dwight E AU - Yin DE AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Goyal, Rakesh K AU - Goyal RK AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Ahmed, Atif A AU - Ahmed AA AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Mitchell, Grace S AU - Mitchell GS AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - St Peter, Shawn D AU - St Peter SD AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Flatt, Terrie G AU - Flatt TG AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Ahmed, Ibrahim A AU - Ahmed IA AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Li, Weijie AU - Li W AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Hendrickson, Richard J AU - Hendrickson RJ AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - August, Keith J AU - August KJ AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA. FAU - Myers, G Doug AU - Myers GD AD - School of Medicine, University of Missouri Kansas City, Children's Mercy Kansas City, Kansas City, Missouri, USA gdmyers@cmh.edu. LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Immunother Cancer JT - Journal for immunotherapy of cancer JID - 101620585 RN - 0 (Receptors, Antigen, T-Cell) RN - Q6C9WHR03O (tisagenlecleucel) SB - IM EIN - J Immunother Cancer. 2021 Oct;9(10):e001225corr1. doi: 10.1136/jitc-2020-001225corr1. PMID: 34635496 MH - BK Virus/pathogenicity MH - Cell Line, Tumor MH - Child, Preschool MH - Cytokine Release Syndrome/*microbiology MH - Disease Management MH - Female MH - Humans MH - Immunotherapy, Adoptive/*adverse effects MH - Infusion Pumps MH - Mucormycosis/diagnosis MH - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy/microbiology MH - Receptors, Antigen, T-Cell/*administration & dosage MH - Shock, Septic/*microbiology MH - Treatment Outcome MH - Young Adult PMC - PMC7818837 OTO - NOTNLM OT - case reports OT - immunotherapy OT - pediatrics COIS- Competing interests: DEY has been an investigator on studies supported by Astellas, Chimerix, Merck, Pfizer, and Viracor-Eurofins. KJA is on the Speaker’s Bureau for and receives support from Novartis Pharmaceuticals. GDM is a consultant and is on the Speaker’s Bureau for Novartis Pharmaceuticals. EMH, RKG, AAA, GSM, SDS, TGF, IAA, WL, and RJH declare that they have no competing interests. EDAT- 2021/01/22 06:00 MHDA- 2021/12/16 06:00 PMCR- 2021/01/20 CRDT- 2021/01/21 05:27 PHST- 2020/12/06 00:00 [accepted] PHST- 2021/01/21 05:27 [entrez] PHST- 2021/01/22 06:00 [pubmed] PHST- 2021/12/16 06:00 [medline] PHST- 2021/01/20 00:00 [pmc-release] AID - jitc-2020-001225 [pii] AID - 10.1136/jitc-2020-001225 [doi] PST - ppublish SO - J Immunother Cancer. 2021 Jan;9(1):e001225. doi: 10.1136/jitc-2020-001225. PMID- 11303876 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20010726 LR - 20190921 IS - 0947-6539 (Print) IS - 0947-6539 (Linking) VI - 7 IP - 5 DP - 2001 Mar 2 TI - An enzyme-labile safety catch linker for synthesis on a soluble polymeric support. PG - 959-71 AB - The development of new and broadly applicable linker groups which are stable under a variety of reaction conditions and allow release of the desired products from the solid support under very mild conditions is of great interest in organic synthesis and combinatorial chemistry. We describe an enzyme-labile safety-catch linker which releases alcohols and amines through i) enzymatic cleavage of an amino group and ii) subsequent lactam formation. The linker group was investigated on different polymeric supports: TentaGel. PEGA, CPG-beads and the soluble polymer POE-6000. From these linker-polymer conjugates 2-methoxy-5-nitrobenzyl alcohol was released by penicillin G acylase catalysed cleavage of a phenylacetamide and attack of the liberated benzylamine on the neighbouring ester group in ortho position. The model study revealed that only in the case of soluble POE-6000 conjugate high yields for the cleavage could be achieved. In the case of the other solid supports the enzyme does not have access to the interior of the polymer matrix. The application of the POE-6000 linker conjugate was investigated for various esters in Pd0-catalysed Heck-, Suzuki- and Sonogashira reactions as well as in a Mitsunobu reaction and cycloadditions. These studies proved that the linker is stable under a broad variety of reaction conditions and that the enzymatic method allows for release of the desired product alcohols under extremely mild conditions at pH 7 and 37 degrees C. In addition, the enzymatic reaction proceeds with complete chemoselectivity, that is other esters or amides are not attacked by the biocatalyst. In addition to alcohols amines can also be cleaved by means of the enzyme-initiated two-step process. In these cases the higher stability of amides as compared to esters requires warming to 60 degrees C to induce cyclization and release of the desired product. FAU - Grether, U AU - Grether U AD - Max-Planck-Institute für molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany. herbert.waldmann@mpi-dortmund.mpg.de FAU - Waldmann, H AU - Waldmann H LA - eng PT - Journal Article PL - Germany TA - Chemistry JT - Chemistry (Weinheim an der Bergstrasse, Germany) JID - 9513783 EDAT- 2001/04/17 10:00 MHDA- 2001/04/17 10:01 CRDT- 2001/04/17 10:00 PHST- 2001/04/17 10:00 [pubmed] PHST- 2001/04/17 10:01 [medline] PHST- 2001/04/17 10:00 [entrez] AID - 10.1002/1521-3765(20010302)7:5<959::AID-CHEM959>3.0.CO;2-K [pii] AID - 10.1002/1521-3765(20010302)7:5<959::aid-chem959>3.0.co;2-k [doi] PST - ppublish SO - Chemistry. 2001 Mar 2;7(5):959-71. doi: 10.1002/1521-3765(20010302)7:5<959::aid-chem959>3.0.co;2-k. PMID- 37381705 OWN - NLM STAT- MEDLINE DCOM- 20231106 LR - 20231106 IS - 1478-596X (Electronic) IS - 1478-5951 (Linking) VI - 19 IP - 6 DP - 2023 Dec TI - Robotic-assisted thoracoscopic lobectomy for synchronous pulmonary sequestration and adenocarcinoma: A case report. PG - e2543 LID - 10.1002/rcs.2543 [doi] AB - BACKGROUND: Pulmonary sequestration (PS) is a congenital pulmonary malformation. Adenocarcinoma arising in PS is extremely rare. METHODS AND RESULTS: We present the first reported case of synchronous intralobar PS and lung adenocarcinoma in the right lower lobe, which was successfully treated using robotic-assisted thoracic surgery (RATS). The robotic system allowed for easy identification, clipping, and dissection of the abnormal artery, highlighting its benefits over traditional surgical approaches. CONCLUSIONS: This case underscores the importance of considering the possibility of coexisting lung cancer in patients with a clinical diagnosis of PS and demonstrates the safety and efficacy of RATS in managing this rare condition. CI - © 2023 John Wiley & Sons Ltd. FAU - He, Hao AU - He H AD - Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Wu, Zeyu AU - Wu Z AD - Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Hu, Qikang AU - Hu Q AD - Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China. FAU - Peng, Muyun AU - Peng M AD - Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China. LA - eng GR - 2021SK53520/Clinical medical technology innovation guidance project of Hunan province/ PT - Case Reports PT - Journal Article DEP - 20230628 PL - England TA - Int J Med Robot JT - The international journal of medical robotics + computer assisted surgery : MRCAS JID - 101250764 SB - IM MH - Humans MH - *Bronchopulmonary Sequestration/diagnostic imaging/surgery MH - *Robotic Surgical Procedures MH - Thoracic Surgery, Video-Assisted MH - Lung MH - *Adenocarcinoma/surgery OTO - NOTNLM OT - lung adenocarcinoma OT - pulmonary sequestration OT - robotic-assisted thoracic surgery EDAT- 2023/06/29 06:43 MHDA- 2023/11/06 06:42 CRDT- 2023/06/29 02:53 PHST- 2023/06/02 00:00 [revised] PHST- 2023/04/23 00:00 [received] PHST- 2023/06/17 00:00 [accepted] PHST- 2023/11/06 06:42 [medline] PHST- 2023/06/29 06:43 [pubmed] PHST- 2023/06/29 02:53 [entrez] AID - 10.1002/rcs.2543 [doi] PST - ppublish SO - Int J Med Robot. 2023 Dec;19(6):e2543. doi: 10.1002/rcs.2543. Epub 2023 Jun 28. PMID- 31484952 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240719 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 9 IP - 1 DP - 2019 Sep 4 TI - Construction of three-dimensional temperature distribution using a network of ultrasonic transducers. PG - 12726 LID - 10.1038/s41598-019-49088-y [doi] LID - 12726 AB - Although the ultrasonic technique for measuring temperature distributions has drawn much attention in recent years, most studies that adopt this technique focus on two-dimensional (2D) systems. Mathematically, extending from 2D to 3D requires higher construction-performing algorithms, as well as more complicated, but extremely crucial, designs of ultrasonic transducer layouts. Otherwise the ill condition of governing-equation matrices will become more serious. Here, we aim at constructing 3D temperature distributions by using a network of properly-installed ultrasonic transducers that can be controlled to transmit and receive ultrasound. In addition, the proposed method is capable of performing this construction procedure in real time, thus monitoring transient temperature distributions and guarantee the safety of operations related to heating or burning. Numerical simulations include constructions for four kinds of temperature distributions, as well as corresponding qualitative and quantitative analyses. Finally, our study offers a guide in developing non-intrusive experimental methods that measure 3D temperature distributions in real time. FAU - Shen, Xuehua AU - Shen X AUID- ORCID: 0000-0002-7150-5212 AD - Schoolof Physics and Information Engineering, Minnan Normal University, Zhangzhou, 363000, China. fj_sxh39@163.com. FAU - Chen, Huanting AU - Chen H AD - Schoolof Physics and Information Engineering, Minnan Normal University, Zhangzhou, 363000, China. htchen23@qq.com. FAU - Shih, Tien-Mo AU - Shih TM AD - Department of Mechanical Engineering, University of California, Berkeley, CA, 94720, USA. FAU - Xiong, Qingyu AU - Xiong Q AD - School of Software Engineering, Chongqing University, Chongqing, 400044, China. FAU - Zhang, Hualin AU - Zhang H AD - Schoolof Physics and Information Engineering, Minnan Normal University, Zhangzhou, 363000, China. LA - eng PT - Journal Article DEP - 20190904 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC6726648 COIS- The authors declare no competing interests. EDAT- 2019/09/06 06:00 MHDA- 2019/09/06 06:01 PMCR- 2019/09/04 CRDT- 2019/09/06 06:00 PHST- 2019/01/09 00:00 [received] PHST- 2019/08/15 00:00 [accepted] PHST- 2019/09/06 06:00 [entrez] PHST- 2019/09/06 06:00 [pubmed] PHST- 2019/09/06 06:01 [medline] PHST- 2019/09/04 00:00 [pmc-release] AID - 10.1038/s41598-019-49088-y [pii] AID - 49088 [pii] AID - 10.1038/s41598-019-49088-y [doi] PST - epublish SO - Sci Rep. 2019 Sep 4;9(1):12726. doi: 10.1038/s41598-019-49088-y. PMID- 39452981 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241027 IS - 2079-4991 (Print) IS - 2079-4991 (Electronic) IS - 2079-4991 (Linking) VI - 14 IP - 20 DP - 2024 Oct 13 TI - Advances in Functional Cellulose Hydrogels as Electrolytes for Flexible Zinc-Ion Batteries. LID - 10.3390/nano14201645 [doi] LID - 1645 AB - Zinc-ion batteries (ZIBs) emerge as leading candidates for a flexible energy storage system, distinguished by high capacity, affordability, and inherent safety. The integration of hydrogel electrolytes, particularly those with saturated aqueous solvents, has significantly enhanced the electrochemical performance of ZIBs while preserving their essential flexibility. Nonetheless, challenges in electrochemical performance under specific conditions highlight the nascent stage of this technology, with numerous technical hurdles awaiting resolution. Addressing these challenges, recent investigations have leveraged the unique properties of cellulose hydrogel-namely, its exceptional toughness, tensile strength, extreme temperature resilience, stimulus responsiveness, and self-healing capabilities-to innovate multifunctional flexible zinc-based batteries. This paper conducts a comprehensive review of the physicochemical attributes of cellulose hydrogel electrolytes within ZIBs. We thoroughly analyze their performance under diverse environmental conditions, offering insights into the current landscape and their future potential. By examining these aspects, we aim to underscore the developmental prospects and the challenges that lie ahead for hydrogel electrolytes in ZIBs, paving the way for further advancement in this promising field. FAU - Xu, Luo AU - Xu L AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Li, Yan AU - Li Y AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Fu, Jianxue AU - Fu J AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Shi, Luwei AU - Shi L AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Li, Chunjie AU - Li C AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Ma, Ruguang AU - Ma R AUID- ORCID: 0000-0001-7587-0818 AD - School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China. LA - eng GR - 52172058/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20241013 PL - Switzerland TA - Nanomaterials (Basel) JT - Nanomaterials (Basel, Switzerland) JID - 101610216 PMC - PMC11510068 OTO - NOTNLM OT - cellulose OT - flexible Zinc-Ion Battery OT - hydrogel COIS- The authors declare no conflicts of interest. EDAT- 2024/10/25 12:24 MHDA- 2024/10/25 12:25 PMCR- 2024/10/13 CRDT- 2024/10/25 10:05 PHST- 2024/09/16 00:00 [received] PHST- 2024/10/06 00:00 [revised] PHST- 2024/10/10 00:00 [accepted] PHST- 2024/10/25 12:25 [medline] PHST- 2024/10/25 12:24 [pubmed] PHST- 2024/10/25 10:05 [entrez] PHST- 2024/10/13 00:00 [pmc-release] AID - nano14201645 [pii] AID - nanomaterials-14-01645 [pii] AID - 10.3390/nano14201645 [doi] PST - epublish SO - Nanomaterials (Basel). 2024 Oct 13;14(20):1645. doi: 10.3390/nano14201645. PMID- 39325258 OWN - NLM STAT- MEDLINE DCOM- 20240926 LR - 20250126 IS - 1437-2320 (Electronic) IS - 0344-5607 (Linking) VI - 47 IP - 1 DP - 2024 Sep 26 TI - Leveraging tardigrade proteins Dsup and CAHS D for enhanced neural protection in neurosurgery and neuroscience. PG - 686 LID - 10.1007/s10143-024-02901-3 [doi] AB - Tardigrades are microscopic organisms known for their remarkable resilience to extreme environmental conditions, including radiation and desiccation. Two key proteins, Dsup (Damage suppressor protein) and CAHS D (Cytoplasmic Abundant Heat Soluble protein D), play crucial roles in this resilience. Dsup protects DNA from radiation-induced damage, while CAHS D stabilizes cellular structures during desiccation by interacting with, but not retaining, water. These unique mechanisms have significant potential applications in neurosurgery and neuroscience. Dsup could inspire the development of protective agents for neural tissues during radiation-based treatments, minimizing collateral damage and improving patient outcomes. Meanwhile, CAHS D's stabilization properties could lead to new neuroprotective strategies, safeguarding brain cells under stress. Together, these tardigrade proteins offer innovative solutions for enhancing neural protection, opening new avenues for treating neurological conditions and improving the safety and efficacy of neurosurgical procedures. CI - © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Chellapandian, Hethesh AU - Chellapandian H AD - Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India. FAU - Jeyachandran, Sivakamavalli AU - Jeyachandran S AD - Lab in Biotechnology and Biosignal Transduction, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-77, Tamil Nadu, India. Sivakamavalli.sdc@saveetha.com. LA - eng PT - Journal Article PT - Letter PT - Retracted Publication PT - Review DEP - 20240926 PL - Germany TA - Neurosurg Rev JT - Neurosurgical review JID - 7908181 SB - IM RIN - Neurosurg Rev. 2025 Jan 27;48(1):87. doi: 10.1007/s10143-025-03254-1. PMID: 39865186 MH - Humans MH - Animals MH - *Tardigrada/physiology MH - Neurosciences MH - Neurosurgical Procedures/methods MH - Neurosurgery OTO - NOTNLM OT - CAHS D protein OT - Dsup protein OT - Neuroprotection OT - Neurosurgery OT - Tardigrades EDAT- 2024/09/26 12:42 MHDA- 2024/09/26 12:43 CRDT- 2024/09/26 11:17 PHST- 2024/09/02 00:00 [received] PHST- 2024/09/15 00:00 [accepted] PHST- 2024/09/04 00:00 [revised] PHST- 2024/09/26 12:43 [medline] PHST- 2024/09/26 12:42 [pubmed] PHST- 2024/09/26 11:17 [entrez] AID - 10.1007/s10143-024-02901-3 [pii] AID - 10.1007/s10143-024-02901-3 [doi] PST - epublish SO - Neurosurg Rev. 2024 Sep 26;47(1):686. doi: 10.1007/s10143-024-02901-3. PMID- 37963976 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240212 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Nov 14 TI - Unboxing machine learning models for concrete strength prediction using XAI. PG - 19892 LID - 10.1038/s41598-023-47169-7 [doi] LID - 19892 AB - Concrete is a cost-effective construction material widely used in various building infrastructure projects. High-performance concrete, characterized by strength and durability, is crucial for structures that must withstand heavy loads and extreme weather conditions. Accurate prediction of concrete strength under different mixtures and loading conditions is essential for optimizing performance, reducing costs, and enhancing safety. Recent advancements in machine learning offer solutions to challenges in structural engineering, including concrete strength prediction. This paper evaluated the performance of eight popular machine learning models, encompassing regression methods such as Linear, Ridge, and LASSO, as well as tree-based models like Decision Trees, Random Forests, XGBoost, SVM, and ANN. The assessment was conducted using a standard dataset comprising 1030 concrete samples. Our experimental results demonstrated that ensemble learning techniques, notably XGBoost, outperformed other algorithms with an R-Square (R(2)) of 0.91 and a Root Mean Squared Error (RMSE) of 4.37. Additionally, we employed the SHAP (SHapley Additive exPlanations) technique to analyze the XGBoost model, providing civil engineers with insights to make informed decisions regarding concrete mix design and construction practices. CI - © 2023. The Author(s). FAU - Elhishi, Sara AU - Elhishi S AD - Department of Information Systems, Faculty of Computers and Information, Mansoura University, P.O. Box: 35516, Mansoura, 35516, Egypt. sara_shaker2008@mans.edu.eg. FAU - Elashry, Asmaa Mohammed AU - Elashry AM AD - Computer Science Department, Faculty of Computers and Information, Mansoura University, Mansoura, 35516, Egypt. FAU - El-Metwally, Sara AU - El-Metwally S AD - Computer Science Department, Faculty of Computers and Information, Mansoura University, Mansoura, 35516, Egypt. LA - eng PT - Journal Article DEP - 20231114 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC10646149 COIS- The authors declare no competing interests. EDAT- 2023/11/15 00:41 MHDA- 2023/11/15 00:42 PMCR- 2023/11/14 CRDT- 2023/11/14 23:31 PHST- 2023/09/15 00:00 [received] PHST- 2023/11/09 00:00 [accepted] PHST- 2023/11/15 00:42 [medline] PHST- 2023/11/15 00:41 [pubmed] PHST- 2023/11/14 23:31 [entrez] PHST- 2023/11/14 00:00 [pmc-release] AID - 10.1038/s41598-023-47169-7 [pii] AID - 47169 [pii] AID - 10.1038/s41598-023-47169-7 [doi] PST - epublish SO - Sci Rep. 2023 Nov 14;13(1):19892. doi: 10.1038/s41598-023-47169-7. PMID- 39018176 OWN - NLM STAT- MEDLINE DCOM- 20240909 LR - 20240909 IS - 1944-7922 (Electronic) IS - 1060-3271 (Linking) VI - 107 IP - 5 DP - 2024 Oct 1 TI - Unveiling Impurities: A Comprehensive RP-HPLC Method for Accurate Atorvastatin Impurity Analysis in Pharmaceuticals Using an Accuracy Profile Approach. PG - 735-748 LID - 10.1093/jaoacint/qsae060 [doi] AB - BACKGROUND: Accurate determination of active pharmaceutical ingredients and impurities is essential for ensuring the safety and effectiveness of medications. This study focuses on the validation of a high-performance liquid chromatography (HPLC) method for quantifying atorvastatin and its impurities, addressing a critical aspect of pharmaceutical analysis. OBJECTIVE: The primary objective is to conduct a comprehensive validation study for the HPLC method, covering specificity assessment, response function establishment, and a detailed analysis of precision, trueness, and tolerance intervals. The emphasis is on demonstrating the method's precision, accuracy, and stability-indicating capabilities across various concentrations and compounds. METHODS: The HPLC method is validated through rigorous assessments, including specificity, response function establishment, and analyses of precision, trueness, and tolerance intervals. Induced degradation experiments are conducted to explore atorvastatin's behavior under extreme conditions. Insights into the compound's synthesis and degradation pathways are provided through a proposed mechanism for intramolecular esterification. RESULTS: The results affirm the precision, accuracy, and stability-indicating capabilities of the validated HPLC method. The method effectively differentiates between atorvastatin and its impurities, showcasing its suitability for pharmaceutical quality control. CONCLUSIONS: The validated HPLC method emerges as a robust and reliable tool for atorvastatin analysis, contributing significantly to pharmaceutical research and quality control. Its application ensures the safety and efficacy of medications, reinforcing its role in pharmaceutical analysis. HIGHLIGHTS: This study not only validates a crucial HPLC method for atorvastatin analysis but also provides insights into the compound's behavior under extreme conditions and its synthesis and degradation pathways. The validated method serves as a cornerstone in pharmaceutical research and quality control, ensuring medication safety and efficacy. CI - © The Author(s) 2024. Published by Oxford University Press on behalf of AOAC INTERNATIONAL. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - El Kacemi, Mounir AU - El Kacemi M AUID- ORCID: 0000-0002-3767-1233 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. FAU - El Orche, Aimen AU - El Orche A AUID- ORCID: 0000-0001-5352-2476 AD - University Hassan II of Casablanca, Faculty of Medicine and Pharmacy, Laboratory of Drug Sciences, Biomedical Research, and Biotechnology, 19, Rue Tarik Ibnou Ziad B.P. 9154, Casablanca, Morocco. FAU - El Bourakadi, Khadija AU - El Bourakadi K AUID- ORCID: 0000-0003-1784-9935 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. FAU - Benchekroun, Yassine Hameda AU - Benchekroun YH AUID- ORCID: 0000-0002-8287-3969 AD - University Sidi Mohamed Ben Abdellah, Faculty of Sciences and Technologies, Laboratory of Organic Chemistry Application, B.P. 2202 - Route d'Imouzzer FES, Morocco. FAU - Echerfaoui, Fouad AU - Echerfaoui F AUID- ORCID: 0000-0002-3548-2105 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. FAU - Karrouchi, Khalid AU - Karrouchi K AUID- ORCID: 0000-0002-8075-8051 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. FAU - Bouatia, Mustapha AU - Bouatia M AUID- ORCID: 0000-0002-6700-4984 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. FAU - El Karbane, Miloud AU - El Karbane M AUID- ORCID: 0000-0001-9629-5517 AD - University Mohammed V, Faculty of Medicine and Pharmacy, Laboratory of Analytical Chemistry Bromatology, Souissi, Rabat 10100, Morocco. LA - eng PT - Journal Article PT - Validation Study PL - England TA - J AOAC Int JT - Journal of AOAC International JID - 9215446 RN - A0JWA85V8F (Atorvastatin) SB - IM MH - *Atorvastatin/analysis/chemistry MH - Chromatography, High Pressure Liquid/methods MH - *Drug Contamination MH - Chromatography, Reverse-Phase/methods EDAT- 2024/07/17 18:42 MHDA- 2024/09/09 18:42 CRDT- 2024/07/17 12:23 PHST- 2023/11/29 00:00 [received] PHST- 2024/06/12 00:00 [revised] PHST- 2024/06/30 00:00 [accepted] PHST- 2024/09/09 18:42 [medline] PHST- 2024/07/17 18:42 [pubmed] PHST- 2024/07/17 12:23 [entrez] AID - 7715911 [pii] AID - 10.1093/jaoacint/qsae060 [doi] PST - ppublish SO - J AOAC Int. 2024 Oct 1;107(5):735-748. doi: 10.1093/jaoacint/qsae060. PMID- 39942086 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250215 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 14 IP - 3 DP - 2025 Feb 4 TI - Antibacterial Activity, Probiotic Potential, and Biocontrol Efficacy of Two Lactic Acid Bacteria Against Penicillium expansum on Fresh Grapes. LID - 10.3390/foods14030493 [doi] LID - 493 AB - Lactic acid bacteria are commonly present in various sources and possess significant probiotic properties. They can inhibit pathogenic bacteria and fungi simultaneously, making them promising candidates as bio-preservatives. This study investigated two potential probiotic strains: Lactiplantibacillus plantarum LR5-2 (isolated from fermented meat products) and Lacticaseibacillus rhamnosus SQ63 (isolated from infant feces). The study evaluated their aggregation ability, anti-pathogenic activity, safety, and tolerance to gastrointestinal conditions, phenol, and bile salts. Additionally, their biological control potential against Penicillium expansum on fresh grapes was assessed. The results demonstrated that both strains exhibited high survival rates under extreme gastrointestinal conditions, enhanced Auto-aggregation, co-aggregation, and hydrophobicity. They displayed strong antioxidant activity and significant antibacterial effects against 11 pathogenic fungi and foodborne pathogens. Biosafety testing revealed that both strains are sensitive to most antibiotics, do not produce biogenic amines, and exhibit no hemolytic or DNase activity. In grapes, L. plantarum LR5-2 and L. rhamnosus SQ63 significantly reduced the incidence and disease index of P. expansum infection. In conclusion, the characterization analysis and bio-preservation experiments revealed that LR5-2 and SQ63 have strong potential as probiotics and bio-preservatives. FAU - Hou, Yuting AU - Hou Y AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Duan, Yaoke AU - Duan Y AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Wu, Guofang AU - Wu G AD - Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China. FAU - Zhang, Jianbo AU - Zhang J AUID- ORCID: 0000-0002-0478-2164 AD - Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China. FAU - Luo, Xuan AU - Luo X AD - Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China. FAU - Zhang, Miao AU - Zhang M AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Pang, Huili AU - Pang H AUID- ORCID: 0000-0002-6846-7518 AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Hao, Yuxuan AU - Hao Y AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Wang, Yanping AU - Wang Y AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Cai, Yimin AU - Cai Y AUID- ORCID: 0000-0003-2650-5210 AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. FAU - Wang, Lei AU - Wang L AD - Plateau Livestock Genetic Resources Protection and Innovative Utilization Key Laboratory of Qinghai Province, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Academy of Animal Science and Veterinary Medicine, Qinghai University, Xining 810016, China. FAU - Tan, Zhongfang AU - Tan Z AD - Henan Key Laboratory of Ion-Beam Green Agriculture Bioengineering, School of Agricultural Sciences, Zhengzhou University, Zhengzhou 450001, China. LA - eng GR - 2024-NK-X03/Department of Science and Technology of Qinghai Province/ PT - Journal Article DEP - 20250204 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC11816955 OTO - NOTNLM OT - antimicrobial properties OT - biological control OT - grape OT - lactic acid bacteria OT - probiotics COIS- The authors declare no conflicts of interest. EDAT- 2025/02/13 11:01 MHDA- 2025/02/13 11:02 PMCR- 2025/02/04 CRDT- 2025/02/13 01:11 PHST- 2024/12/16 00:00 [received] PHST- 2025/01/25 00:00 [revised] PHST- 2025/01/30 00:00 [accepted] PHST- 2025/02/13 11:02 [medline] PHST- 2025/02/13 11:01 [pubmed] PHST- 2025/02/13 01:11 [entrez] PHST- 2025/02/04 00:00 [pmc-release] AID - foods14030493 [pii] AID - foods-14-00493 [pii] AID - 10.3390/foods14030493 [doi] PST - epublish SO - Foods. 2025 Feb 4;14(3):493. doi: 10.3390/foods14030493. PMID- 33527617 OWN - NLM STAT- MEDLINE DCOM- 20211015 LR - 20211015 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) VI - 22 Suppl 2 DP - 2021 Mar TI - Pathogenesis of obesity and cardiometabolic diseases: From the legacy of Ancel Keys to current concepts. PG - e13193 LID - 10.1111/obr.13193 [doi] AB - Several areas of research into the prevention and treatment of obesity today can be traced to one or more of the scientific works pioneered by Ancel Keys between the 1930s to 1970s in fields that cut across the physiology of extremes and public health nutrition. These range from his classical studies into how body and mind respond to chronic exposure to hypoxia in "The Physiology of Life at High Altitudes" or to simulated famine under controlled laboratory conditions in "The Biology of Human Starvation", the impact of diet and lifestyle on cardiovascular morbidity and mortality in "The Seven Countries Study," to the "Indices of Relative Weight and Obesity" in which he identified what has since been the most widely utilized diagnostic tool to monitor obesity across populations worldwide and which he coined as the body mass index. The contribution of Ancel Keys to medical sciences through his observations, analytical approaches, and research output of his classic studies, and how these have (and continue) to impact on a plethora of current concepts in obesity research today, are embodied in the eight review articles that constitute this supplement reporting the proceedings of the 10th Fribourg Obesity Research Conference. The aim of this introductory paper is to put into perspective the legacy of Ancel Keys to current concepts that are encapsulated in these review articles that cover research areas that include (i) the diagnosis of obesity for health risks; (ii) the role of dietary fat types in the pathogenesis of obesity and cardiometabolic diseases; (iii) the rationale, efficacy and safety of low carbohydrate ketogenic diets, or the therapeutic potential of hypoxic conditioning, in weight management programs; (iv) the psychological and physiological basis of the "famine reaction" that counters therapeutic dieting and facilitates weight regain; and (v) the potential impact of weight cycling and yoyo dieting on risks for later obesity and cardiometabolic diseases. CI - © 2021 World Obesity Federation. FAU - Dulloo, Abdul G AU - Dulloo AG AUID- ORCID: 0000-0003-3877-6149 AD - Faculty of Science and Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, Fribourg, Switzerland. FAU - Montani, Jean-Pierre AU - Montani JP AD - Faculty of Science and Medicine, Department of Endocrinology, Metabolism and Cardiovascular System, University of Fribourg, Fribourg, Switzerland. LA - eng PT - Journal Article PT - Review DEP - 20210201 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM MH - Body Mass Index MH - *Cardiovascular Diseases/etiology MH - Diet MH - Humans MH - Life Style MH - *Obesity OTO - NOTNLM OT - body composition OT - dietary fats OT - hypoxia OT - starvation EDAT- 2021/02/03 06:00 MHDA- 2021/10/16 06:00 CRDT- 2021/02/02 06:19 PHST- 2020/12/04 00:00 [received] PHST- 2020/12/07 00:00 [accepted] PHST- 2021/02/03 06:00 [pubmed] PHST- 2021/10/16 06:00 [medline] PHST- 2021/02/02 06:19 [entrez] AID - 10.1111/obr.13193 [doi] PST - ppublish SO - Obes Rev. 2021 Mar;22 Suppl 2:e13193. doi: 10.1111/obr.13193. Epub 2021 Feb 1. PMID- 36254787 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20221221 LR - 20221222 IS - 1864-564X (Electronic) IS - 1864-5631 (Linking) VI - 15 IP - 24 DP - 2022 Dec 20 TI - Thermal-Stable Separators: Design Principles and Strategies Towards Safe Lithium-Ion Battery Operations. PG - e202201464 LID - 10.1002/cssc.202201464 [doi] AB - Lithium-ion batteries (LIBs) are momentous energy storage devices, which have been rapidly developed due to their high energy density, long lifetime, and low self-discharge rate. However, the frequent occurrence of fire accidents in laptops, electric vehicles, and mobile phones caused by thermal runaway of the inside batteries constantly reminds us of the urgency in pursuing high-safety LIBs with high performance. To this end, this Review surveyed the state-of-the-art developments of high-temperature-resistant separators for highly safe LIBs with excellent electrochemical performance. Firstly, the basic properties of separators (e. g., thickness, porosity, pore size, wettability, mechanical strength, and thermal stability) in constructing commercialized LIBs were introduced. Secondly, the working mechanisms of advanced separators with different melting points acting in the thermal runaway stage were discussed in terms of improving battery safety. Thirdly, rational design strategies for constructing high-temperature-resistant separators for LIBs with high safety were summarized and discussed, including graft modification, blend modification, and multilayer composite modification strategies. Finally, the current obstacles and future research directions in the field of high-temperature-resistant separators were highlighted. These design ideas are expected to be applied to other types of high-temperature-resistant energy storage systems working under extreme conditions. CI - © 2022 Wiley-VCH GmbH. FAU - Lin, Wanxin AU - Lin W AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. FAU - Wang, Feng AU - Wang F AD - Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, P. R. China. FAU - Wang, Huibo AU - Wang H AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. AD - Institute of Applied Physics and Materials Engineering, University of Macau, Macau, 999078, P. R. China. FAU - Li, Heng AU - Li H AD - State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P. R. China. FAU - Fan, You AU - Fan Y AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. FAU - Chan, Dan AU - Chan D AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. FAU - Chen, Shuwei AU - Chen S AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. FAU - Tang, Yuxin AU - Tang Y AUID- ORCID: 0000-0001-9348-323X AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. FAU - Zhang, Yanyan AU - Zhang Y AD - College of Chemical Engineering, Fuzhou University, Fuzhou, 350116, P. R. China. LA - eng GR - 21875040/National Natural Science Foundation of China/ GR - 22279017/National Natural Science Foundation of China/ GR - 21905051/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20221115 PL - Germany TA - ChemSusChem JT - ChemSusChem JID - 101319536 SB - IM OTO - NOTNLM OT - batteries OT - electrolytes OT - energy storage OT - high-safety OT - separators EDAT- 2022/10/19 06:00 MHDA- 2022/10/19 06:01 CRDT- 2022/10/18 05:33 PHST- 2022/10/16 00:00 [revised] PHST- 2022/07/31 00:00 [received] PHST- 2022/10/19 06:00 [pubmed] PHST- 2022/10/19 06:01 [medline] PHST- 2022/10/18 05:33 [entrez] AID - 10.1002/cssc.202201464 [doi] PST - ppublish SO - ChemSusChem. 2022 Dec 20;15(24):e202201464. doi: 10.1002/cssc.202201464. Epub 2022 Nov 15. PMID- 27775120 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20180118 LR - 20180118 IS - 1460-4744 (Electronic) IS - 0306-0012 (Linking) VI - 45 IP - 21 DP - 2016 Oct 24 TI - High temperature electrical energy storage: advances, challenges, and frontiers. PG - 5848-5887 AB - With the ongoing global effort to reduce greenhouse gas emission and dependence on oil, electrical energy storage (EES) devices such as Li-ion batteries and supercapacitors have become ubiquitous. Today, EES devices are entering the broader energy use arena and playing key roles in energy storage, transfer, and delivery within, for example, electric vehicles, large-scale grid storage, and sensors located in harsh environmental conditions, where performance at temperatures greater than 25 °C are required. The safety and high temperature durability are as critical or more so than other essential characteristics (e.g., capacity, energy and power density) for safe power output and long lifespan. Consequently, significant efforts are underway to design, fabricate, and evaluate EES devices along with characterization of device performance limitations such as thermal runaway and aging. Energy storage under extreme conditions is limited by the material properties of electrolytes, electrodes, and their synergetic interactions, and thus significant opportunities exist for chemical advancements and technological improvements. In this review, we present a comprehensive analysis of different applications associated with high temperature use (40-200 °C), recent advances in the development of reformulated or novel materials (including ionic liquids, solid polymer electrolytes, ceramics, and Si, LiFePO(4), and LiMn(2)O(4) electrodes) with high thermal stability, and their demonstrative use in EES devices. Finally, we present a critical overview of the limitations of current high temperature systems and evaluate the future outlook of high temperature batteries with well-controlled safety, high energy/power density, and operation over a wide temperature range. FAU - Lin, Xinrong AU - Lin X AD - Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA 02115, USA. mgrin@bu.edu. FAU - Salari, Maryam AU - Salari M AD - Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA 02115, USA. mgrin@bu.edu. FAU - Arava, Leela Mohana Reddy AU - Arava LM AD - Department of Mechanical Engineering, Wayne State University, Detroit, MI 48202, USA. FAU - Ajayan, Pulickel M AU - Ajayan PM AD - Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005, USA. FAU - Grinstaff, Mark W AU - Grinstaff MW AUID- ORCID: 0000-0002-5453-3668 AD - Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA 02115, USA. mgrin@bu.edu. LA - eng PT - Journal Article PT - Review PL - England TA - Chem Soc Rev JT - Chemical Society reviews JID - 0335405 EDAT- 2016/10/25 06:00 MHDA- 2016/10/25 06:01 CRDT- 2016/10/25 06:00 PHST- 2016/10/25 06:00 [pubmed] PHST- 2016/10/25 06:01 [medline] PHST- 2016/10/25 06:00 [entrez] AID - 10.1039/c6cs00012f [doi] PST - ppublish SO - Chem Soc Rev. 2016 Oct 24;45(21):5848-5887. doi: 10.1039/c6cs00012f. PMID- 39787655 OWN - NLM STAT- MEDLINE DCOM- 20250210 LR - 20250210 IS - 1879-1700 (Electronic) IS - 0265-931X (Linking) VI - 282 DP - 2025 Feb TI - Spatial unfolding of an extended La-140 source within a 0.5 km-wide exclusion zone using Compton gamma imaging measurements. PG - 107605 LID - S0265-931X(24)00237-6 [pii] LID - 10.1016/j.jenvrad.2024.107605 [doi] AB - Results from applying an advanced spatial-unfolding technique to outdoor-trial data acquired with a Silicon photomultiplier-based Compton Telescope for Safety and Security (SCoTSS) gamma imager during perimeter survey of a distributed La-140 source lying within a 500 m x 500 m exclusion zone are presented. A synthetic-data version of the experiment was also modelled using Monte Carlo simulations and reconstructed. For both experimental and synthetic data the method faithfully reproduces the shape of the activity distribution, and for synthetic data the total activity is reproduced as well. However, for the experimental data the method underestimates the total activity by a factor of six. This can be accounted for by environmental snow and soil conditions not included in the detector response functions. This application of the Compton gamma imager survey-data inversion method demonstrates its applicability under austere conditions wherein extreme weather and transportation constraints severely impacted the quality of the data collected. The trial shows that the method has widespread applicability in the radiological and nuclear safety and security field, particularly for scenarios in which a threat material or contaminated area lies within a no-entry or no-fly zone. CI - Crown Copyright © 2025. Published by Elsevier Ltd. All rights reserved. FAU - Murtha, N J AU - Murtha NJ AD - Department of Physics, Carleton University, Ottawa, Ontario, Canada; Canadian Hazards Information Service, Natural Resources Canada, Ottawa, Ontario, Canada; Ionizing Radiation Standards, Metrology Research Centre, National Research Council, Canada. FAU - Saull, P R B AU - Saull PRB AD - Department of Physics, Carleton University, Ottawa, Ontario, Canada; Ionizing Radiation Standards, Metrology Research Centre, National Research Council, Canada. Electronic address: patrick.saull@nrc-cnrc.gc.ca. FAU - Sinclair, L E AU - Sinclair LE AD - Department of Physics, Carleton University, Ottawa, Ontario, Canada; Department of Earth Sciences, Carleton University, Ottawa, Ontario, Canada; Canadian Hazards Information Service, Natural Resources Canada, Ottawa, Ontario, Canada. FAU - MacLeod, A M L AU - MacLeod AML AD - Ionizing Radiation Standards, Metrology Research Centre, National Research Council, Canada. FAU - McCann, A AU - McCann A AD - Canadian Hazards Information Service, Natural Resources Canada, Ottawa, Ontario, Canada. LA - eng PT - Journal Article DEP - 20250108 PL - England TA - J Environ Radioact JT - Journal of environmental radioactivity JID - 8508119 RN - 6I3K30563S (Lanthanum) SB - IM MH - *Radiation Monitoring/methods MH - Monte Carlo Method MH - Lanthanum MH - Gamma Rays OTO - NOTNLM OT - Compton gamma imaging OT - Data unfolding OT - Detector response OT - Radiation detection OT - Radiological security OT - Tomography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/10 00:21 MHDA- 2025/02/11 00:18 CRDT- 2025/01/09 18:00 PHST- 2024/08/21 00:00 [received] PHST- 2024/12/09 00:00 [revised] PHST- 2024/12/16 00:00 [accepted] PHST- 2025/02/11 00:18 [medline] PHST- 2025/01/10 00:21 [pubmed] PHST- 2025/01/09 18:00 [entrez] AID - S0265-931X(24)00237-6 [pii] AID - 10.1016/j.jenvrad.2024.107605 [doi] PST - ppublish SO - J Environ Radioact. 2025 Feb;282:107605. doi: 10.1016/j.jenvrad.2024.107605. Epub 2025 Jan 8. PMID- 29461812 OWN - NLM STAT- MEDLINE DCOM- 20180412 LR - 20180412 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 66 IP - 11 DP - 2018 Mar 21 TI - Molecularly Imprinted Polymer as an Antibody Substitution in Pseudo-immunoassays for Chemical Contaminants in Food and Environmental Samples. PG - 2561-2571 LID - 10.1021/acs.jafc.7b05577 [doi] AB - The chemical contaminants in food and the environment are quite harmful to food safety and human health. Rapid, accurate, and cheap detection can effectively control the potential risks derived from these chemical contaminants. Among all detection methods, the immunoassay based on the specific interaction of antibody-analyte is one of the most widely used techniques in the field. However, biological antibodies employed in the immunoassay usually cannot tolerate extreme conditions, resulting in an unstable state in both physical and chemical profiles. Molecularly imprinted polymers (MIPs) are a class of polymers with specific molecular recognition abilities, which are highly robust, showing excellent operational stability under a wide variety of conditions. Recently, MIPs have been used in biomimetic immunoassays for chemical contaminants as an antibody substitute in food and the environment. Here, we reviewed these applications of MIPs incorporated in different analytical platforms, such as enzyme-linked immunosorbent assay, fluorescent immunoassay, chemiluminescent immunoassay, electrochemical immunoassay, microfluidic paper-based immunoassay, and homogeneous immunoassay, and discussed current challenges and future trends in the use of MIPs in biomimetic immunoassays. FAU - Chen, Chaochao AU - Chen C AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Luo, Jiaxun AU - Luo J AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Li, Chenglong AU - Li C AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Ma, Mingfang AU - Ma M AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Yu, Wenbo AU - Yu W AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Shen, Jianzhong AU - Shen J AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. FAU - Wang, Zhanhui AU - Wang Z AUID- ORCID: 0000-0002-0167-9559 AD - Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine , China Agricultural University , Beijing 100193 , People's Republic of China. AD - Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety , Beijing 100193 , People's Republic of China. AD - Beijing Laboratory for Food Quality and Safety , Beijing 100193 , People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20180228 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 0 (Antibodies) RN - 0 (Environmental Pollutants) RN - 0 (Polymers) SB - IM MH - Antibodies/chemistry MH - Environmental Pollutants/*analysis MH - Food Contamination/*analysis MH - Immunoassay/*instrumentation/methods MH - Molecular Imprinting MH - Polymers/chemical synthesis/*chemistry OTO - NOTNLM OT - biomimetic immunoassay OT - chemical contaminants OT - environment OT - food OT - molecularly imprinted polymers EDAT- 2018/02/21 06:00 MHDA- 2018/04/13 06:00 CRDT- 2018/02/21 06:00 PHST- 2018/02/21 06:00 [pubmed] PHST- 2018/04/13 06:00 [medline] PHST- 2018/02/21 06:00 [entrez] AID - 10.1021/acs.jafc.7b05577 [doi] PST - ppublish SO - J Agric Food Chem. 2018 Mar 21;66(11):2561-2571. doi: 10.1021/acs.jafc.7b05577. Epub 2018 Feb 28. PMID- 26304367 OWN - NLM STAT- MEDLINE DCOM- 20160505 LR - 20181202 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 192 DP - 2016 Feb 1 TI - In vitro digestion of luteinizing hormone releasing hormone analog (LHRHa) using simulated gastric conditions in assessing human food safety. PG - 409-14 LID - S0308-8146(15)00983-8 [pii] LID - 10.1016/j.foodchem.2015.06.091 [doi] AB - Luteinizing hormone releasing hormone analog (LHRHa, des Gly10, [D-Ala6] ethylamide) is routinely applied for induced spawning of fish. Simulated gastric acid and pepsin were used to mimic human digestion in vitro to determine the stability of LHRHa upon possible ingestion. In vitro cleavage of LHRHa was quantified using UPLC-MS, ultra-performance liquid chromatography-mass spectrometry. LHRHa was broken down mainly into two fragments from Glp-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (LHRHa) to Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (fragment 1) and Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt (fragment 2). By 24h of incubation, LHRHa was completely digested or barely detectable if the starting material was at 250 ng/μl. If the starting concentration was at 5 ng/μl, LHRHa was completely digested by 5h of incubation, or earlier. In both extreme scenarios, the results indicated that LHRHa would be digested completely in the human stomach and would pose no risk in human food consumption. This study supports the assertion that LHRHa used as a spawning aid would not pose a human food safety risk. CI - Copyright © 2015 Elsevier Ltd. All rights reserved. FAU - Su, Baofeng AU - Su B AD - School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, AL 36849, USA. FAU - Wu, Yonnie AU - Wu Y AD - Department of Chemistry, Mass Spec Center, 172 Chemistry Building, Auburn University, AL 36849, USA. FAU - Shang, Mei AU - Shang M AD - School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, AL 36849, USA. FAU - Penton, Tom AU - Penton T AD - Eagle Aquaculture Inc., Auburn, AL 36830, USA. FAU - Lawrence, Sam AU - Lawrence S AD - Eagle Aquaculture Inc., Auburn, AL 36830, USA. FAU - Dunham, Rex A AU - Dunham RA AD - School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, AL 36849, USA. Electronic address: dunhara@auburn.edu. LA - eng PT - Journal Article DEP - 20150703 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) SB - IM MH - Animals MH - Food Safety MH - Gonadotropin-Releasing Hormone/*analogs & derivatives/metabolism MH - Humans MH - In Vitro Techniques OTO - NOTNLM OT - Biological activity OT - Fish spawning aid OT - Food safety OT - In vitro digestion OT - LHRHa OT - Simulated gastric acid EDAT- 2015/08/26 06:00 MHDA- 2016/05/06 06:00 CRDT- 2015/08/26 06:00 PHST- 2014/10/18 00:00 [received] PHST- 2015/06/18 00:00 [revised] PHST- 2015/06/26 00:00 [accepted] PHST- 2015/08/26 06:00 [entrez] PHST- 2015/08/26 06:00 [pubmed] PHST- 2016/05/06 06:00 [medline] AID - S0308-8146(15)00983-8 [pii] AID - 10.1016/j.foodchem.2015.06.091 [doi] PST - ppublish SO - Food Chem. 2016 Feb 1;192:409-14. doi: 10.1016/j.foodchem.2015.06.091. Epub 2015 Jul 3. PMID- 36848503 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230525 LR - 20230525 IS - 1521-4095 (Electronic) IS - 0935-9648 (Linking) VI - 35 IP - 21 DP - 2023 May TI - Ionic Liquid "Water Pocket" for Stable and Environment-Adaptable Aqueous Zinc Metal Batteries. PG - e2210789 LID - 10.1002/adma.202210789 [doi] AB - The strong reactivity of water in aqueous electrolytes toward metallic zinc (Zn), especially at aggressive operating conditions, remains the fundamental obstacle to the commercialization of aqueous zinc metal batteries (AZMBs). Here, a water-immiscible ionic liquid diluent 1-ethyl-3-methylimidazolium bis(fluorosulfonyl)amide (EmimFSI) is reported that can substantially suppress the water activity of aqueous electrolyte by serving as a "water pocket", enveloping the highly active H(2) O-dominated Zn(2+) solvates and protecting them from parasitic reactions. During Zn deposition, the cation Emim(+) and anion FSI(-) function respectively in mitigating the tip effect and regulating the solid electrolyte interphase (SEI), thereby favoring a smooth Zn deposition layer protected by inorganic species-enriched SEI featuring high uniformity and stability. Combined with the boosted chemical/electrochemical stability endowed by the intrinsic merits of ionic liquid, this ionic liquid-incorporated aqueous electrolyte (IL-AE) enables the stable operation of Zn||Zn(0.25) V(2) O(5) ·nH(2) O cells even at a challenging temperature of 60 °C (>85% capacity retention over 400 cycles). Finally, as an incidental but practically valuable benefit, the near-zero vapor pressure nature of ionic liquid allows the efficient separation and recovery of high-value components from the spent electrolyte via a mild and green approach, promising the sustainable future of IL-AE in realizing practical AZMBs. CI - © 2023 Wiley-VCH GmbH. FAU - Yu, Le AU - Yu L AD - School of Resource and Environmental Sciences, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China. FAU - Huang, Jing AU - Huang J AD - School of Resource and Environmental Sciences, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China. FAU - Wang, Sijun AU - Wang S AD - School of Resource and Environmental Sciences, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China. FAU - Qi, Luhe AU - Qi L AD - School of Resource and Environmental Sciences, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China. FAU - Wang, Shanshan AU - Wang S AD - College of Chemical Engineering, Nanjing Forestry University, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass, Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing, 210037, China. FAU - Chen, Chaoji AU - Chen C AUID- ORCID: 0000-0001-9553-554X AD - School of Resource and Environmental Sciences, Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, 430079, China. LA - eng GR - 691000003/Wuhan University/ GR - 52202288/National Natural Science Foundation of China/ GR - 2022M710106/China Postdoctoral Science Foundation/ PT - Journal Article DEP - 20230402 PL - Germany TA - Adv Mater JT - Advanced materials (Deerfield Beach, Fla.) JID - 9885358 SB - IM OTO - NOTNLM OT - aqueous zinc metal batteries OT - extreme conditions OT - ionic liquid OT - safety OT - zinc dendrite EDAT- 2023/02/28 06:00 MHDA- 2023/02/28 06:01 CRDT- 2023/02/27 15:03 PHST- 2023/02/17 00:00 [revised] PHST- 2022/11/20 00:00 [received] PHST- 2023/02/28 06:01 [medline] PHST- 2023/02/28 06:00 [pubmed] PHST- 2023/02/27 15:03 [entrez] AID - 10.1002/adma.202210789 [doi] PST - ppublish SO - Adv Mater. 2023 May;35(21):e2210789. doi: 10.1002/adma.202210789. Epub 2023 Apr 2. PMID- 19867347 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100623 LR - 20211020 IS - 0022-1007 (Print) IS - 1540-9538 (Electronic) IS - 0022-1007 (Linking) VI - 12 IP - 5 DP - 1910 Sep 1 TI - THE RELATION OF FATTY DEGENERATION TO THE OXIDATION OF PURINES BY LIVER CELLS. PG - 607-15 AB - These experiments show that it is possible to cause, by the proper use of hydrazine and phosphorus, a very high degree of fatty change in the liver with a minimum of necrosis, involving alike both peripheral and central portions of the lobule and thus eliminating the " factor of safety" or residual normal cells. Nevertheless, it is found that such fatty liver tissue has not lost in the least its power to oxidize uric acid when acting upon it in vitro with abundant air supply, nor is the power to oxidize xanthine to uric acid noticeably diminished. Since these two enzymes, and especially the uricolytic enzyme, are about the last to appear in the development of the animal kingdom and also of the individual mammal, it is to be expected that they will be among the first of the enzymes to be destroyed by injurious agencies, but evidently they are not affected by conditions that lead to the highest degree of fatty metamorphosis of the cytoplasm of the hepatic cells. While these experiments merely prove that extreme fatty degeneration does not destroy or appreciably diminish the power of liver cells to oxidize uric acid and xanthine in vitro, yet they suggest that in general fatty degeneration is probably not essentially incompatible with a high degree of metabolic activity by the affected cells. It is possible that in the living tissue functional activity may be decreased secondarily by fatty metamorphosis, as, for example, by the enlarged fatty cells compressing the capillaries and reducing circulatory activity, or by modification of diffusion through the cell by the fat deposits, independent of any deleterious influence upon the cellular enzymes themselves. Other experiments will be required to determine whether steatogenic poisons leave intrahepatic enzymes other than the uricase equally unaffected, but as it has already been shown by Jacoby that the autolytic enzymes and aldehydase in the liver cells are not destroyed by phosphorus poisoning, and Abderhalden and Schittenhelm* found that peptids are hydrolyzed fully as rapidly by phosphorus livers as by normal livers, it seems probable that extreme fatty metamorphosis is not associated with any serious injury to the enzymes by which the liver cells perform their metabolic functions, with the possible exception of those enzymes concerned with the metabolism of fats. FAU - Wells, H G AU - Wells HG AD - Department of Pathology, University of Chicago. LA - eng PT - Journal Article PL - United States TA - J Exp Med JT - The Journal of experimental medicine JID - 2985109R PMC - PMC2124813 EDAT- 1910/09/01 00:00 MHDA- 1910/09/01 00:01 PMCR- 1911/03/01 CRDT- 2009/10/30 06:00 PHST- 2009/10/30 06:00 [entrez] PHST- 1910/09/01 00:00 [pubmed] PHST- 1910/09/01 00:01 [medline] PHST- 1911/03/01 00:00 [pmc-release] AID - 10.1084/jem.12.5.607 [doi] PST - ppublish SO - J Exp Med. 1910 Sep 1;12(5):607-15. doi: 10.1084/jem.12.5.607. PMID- 32954858 OWN - NLM STAT- MEDLINE DCOM- 20210311 LR - 20220417 IS - 1744-764X (Electronic) IS - 1474-0338 (Linking) VI - 19 IP - 11 DP - 2020 Nov TI - A safety review of drugs used for the treatment of retinopathy of prematurity. PG - 1409-1418 LID - 10.1080/14740338.2020.1826927 [doi] AB - INTRODUCTION: Retinopathy of Prematurity (ROP) is a sight-threatening disease representing one of the main disabling diseases affecting premature newborns. Presently, ROP is treated by surgical interventions and drug therapies are limited to the off-label use of a little amount of molecules approved for other pathologies. AREAS COVERED: Many drugs that may potentially be used in treating ROP are recently proposed, in many cases after the demonstration of their effectiveness in preclinical studies. In this review, the authors discuss safety and effectiveness of the main proposed approaches in the pharmacologic treatment of the disease, including approaches based on oxygen therapy and nutritional interventions. EXPERT OPINION: Surgical approaches to ROP are not without side effects. However, most of the proposed pharmacologic interventions can also raise specific concerns. In particular, these approaches follow a curative paradigm and are proposed in patients once the disease has progressed, with an effectiveness that is often smaller than expected. A goal in the treatment of ROP would be moving the paradigm toward a preventive approach that could be potentially effective in treating extremely low birth weight preterm infants before ROP becomes manifest. FAU - Filippi, Luca AU - Filippi L AUID- ORCID: 0000-0001-5310-9147 AD - Neonatal Intensive Care Unit, Medical Surgical Fetal-Neonatal Department, "A. Meyer" University Children's Hospital , Florence, Italy. FAU - Dal Monte, Massimo AU - Dal Monte M AD - Department of Biology, University of Pisa , Pisa, Italy. LA - eng PT - Journal Article PT - Review DEP - 20200929 PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - S88TT14065 (Oxygen) SB - IM MH - Animals MH - Humans MH - Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Infant, Premature MH - Nutritional Support MH - Off-Label Use MH - Oxygen/*administration & dosage MH - Retinopathy of Prematurity/pathology/physiopathology/*therapy OTO - NOTNLM OT - Antioxidants OT - IGF-1 OT - NSAIDs OT - VEGF OT - anti-VEGF OT - hyperoxia/hypoxia OT - propranolol OT - steroids EDAT- 2020/09/22 06:00 MHDA- 2021/03/12 06:00 CRDT- 2020/09/21 08:40 PHST- 2020/09/22 06:00 [pubmed] PHST- 2021/03/12 06:00 [medline] PHST- 2020/09/21 08:40 [entrez] AID - 10.1080/14740338.2020.1826927 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2020 Nov;19(11):1409-1418. doi: 10.1080/14740338.2020.1826927. Epub 2020 Sep 29. PMID- 14678345 OWN - NLM STAT- MEDLINE DCOM- 20040209 LR - 20220409 IS - 0306-5251 (Print) IS - 1365-2125 (Electronic) IS - 0306-5251 (Linking) VI - 57 IP - 1 DP - 2004 Jan TI - Differences between clinical trials and postmarketing use. PG - 86-92 AB - AIMS: Clinical trials constitute the gold standard to assess the efficacy and safety of new medicines. However, because they are conducted in standardized conditions far from the real world of prescription and use, discrepancies in patient selection or treatment conditions may alter both the effectiveness and risks. On the basis of three examples, our objectives were to study the differences between the characteristics of treated populations and treatment patterns in clinical trials and in postmarketing settings and to discuss the potential consequences on actual efficacy and safety. METHODS: Treated populations were compared with patients included in premarketing clinical trials. Comparisons were made on the basis of demographic characteristics and treatment patterns. RESULTS: Whatever the indicator and the drug studied, differences were observed: from 0.04% to 63% for tacrine, from 0% to 37% for celecoxib and from 6% to 52% for simvastatin, with possible consequences on the effectiveness and safety of the drug concerned. Our results confirm the under-representation of women and elderly patients in premarketing clinical trials, e.g. an M : F ratio of 4.6 in clinical trails of simvastatin vs 1.0 in the joint population. Moreover, the concomitant use of medicines was made extremely restrictive by the protocols of these trials while this was not the case in the postmarketing phase. This has possible consequences on the effectiveness and safety of the drug concerned. CONCLUSIONS: These results plead for systematic ad hoc observational postmarketing studies for any novel and/or expensive medicine to assess the relevance of premarketing data. FAU - Martin, Karin AU - Martin K AD - Département de Pharmacologie, Université Victor Segalen, Bordeaux 2, Bordeaux, France. karin.martin@pharmaco.u-bordeaux2.fr FAU - Bégaud, Bernard AU - Bégaud B FAU - Latry, Philippe AU - Latry P FAU - Miremont-Salamé, Ghada AU - Miremont-Salamé G FAU - Fourrier, Annie AU - Fourrier A FAU - Moore, Nicholas AU - Moore N LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Br J Clin Pharmacol JT - British journal of clinical pharmacology JID - 7503323 RN - 0 (Pyrazoles) RN - 0 (Sulfonamides) RN - 4VX7YNB537 (Tacrine) RN - AGG2FN16EV (Simvastatin) RN - JCX84Q7J1L (Celecoxib) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Celecoxib MH - *Clinical Trials as Topic MH - Contraindications MH - Female MH - Humans MH - Male MH - Middle Aged MH - Product Surveillance, Postmarketing MH - Pyrazoles MH - Simvastatin/*therapeutic use MH - Sulfonamides/*therapeutic use MH - Tacrine/*therapeutic use PMC - PMC1884419 EDAT- 2003/12/18 05:00 MHDA- 2004/02/11 05:00 PMCR- 2004/07/01 CRDT- 2003/12/18 05:00 PHST- 2003/12/18 05:00 [pubmed] PHST- 2004/02/11 05:00 [medline] PHST- 2003/12/18 05:00 [entrez] PHST- 2004/07/01 00:00 [pmc-release] AID - 1953 [pii] AID - 10.1046/j.1365-2125.2003.01953.x [doi] PST - ppublish SO - Br J Clin Pharmacol. 2004 Jan;57(1):86-92. doi: 10.1046/j.1365-2125.2003.01953.x. PMID- 36947443 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230411 LR - 20230415 IS - 1520-5827 (Electronic) IS - 0743-7463 (Print) IS - 0743-7463 (Linking) VI - 39 IP - 14 DP - 2023 Apr 11 TI - Extreme Gradient Boosting to Predict Atomic Layer Deposition for Platinum Nano-Film Coating. PG - 4984-4992 LID - 10.1021/acs.langmuir.2c03465 [doi] AB - Extreme gradient boosting (XGBoost) is an artificial intelligence algorithm capable of high accuracy and low inference time. The current study applies this XGBoost to the production of platinum nano-film coating through atomic layer deposition (ALD). In order to generate a database for model development, platinum is coated on α-Al2O3 using a rotary-type ALD equipment. The process is controlled by four parameters: process temperature, stop valve time, precursor pulse time, and reactant pulse time. A total of 625 samples according to different process conditions are obtained. The ALD coating index is used as the Al/Pt component ratio through ICP-AES analysis during postprocessing. The four process parameters serve as the input data and produces the Al/Pt component ratio as the output data. The postprocessed data set is randomly divided into 500 training samples and 125 test samples. XGBoost demonstrates 99.9% accuracy and a coefficient of determination of 0.99. The inference time is lower than that of random forest regression, in addition to a higher prediction safety than that of the light gradient boosting machine. FAU - Yoon, Sung-Ho AU - Yoon SH AD - Electronic Convergence Materials and Device Research Center, Korea Electronics Technology Institute, 25, Saenari-ro, Bundang-gu, Seongnam 13509, Republic of Korea. AD - Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. AD - Department of Nano Engineering, Department of Nano Science and Technology, SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Jeon, Jun-Hyeok AU - Jeon JH AD - Electronic Convergence Materials and Device Research Center, Korea Electronics Technology Institute, 25, Saenari-ro, Bundang-gu, Seongnam 13509, Republic of Korea. AD - Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Cho, Seung-Beom AU - Cho SB AD - Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Nacpil, Edric John Cruz AU - Nacpil EJC AD - Department of Nano Engineering, Department of Nano Science and Technology, SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Jeon, Il AU - Jeon I AUID- ORCID: 0000-0002-4220-8374 AD - Department of Nano Engineering, Department of Nano Science and Technology, SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Choi, Jae-Boong AU - Choi JB AD - Mechanical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea. FAU - Kim, Hyeongkeun AU - Kim H AUID- ORCID: 0000-0002-7875-8853 AD - Electronic Convergence Materials and Device Research Center, Korea Electronics Technology Institute, 25, Saenari-ro, Bundang-gu, Seongnam 13509, Republic of Korea. LA - eng PT - Journal Article DEP - 20230322 PL - United States TA - Langmuir JT - Langmuir : the ACS journal of surfaces and colloids JID - 9882736 SB - IM PMC - PMC10100550 COIS- The authors declare no competing financial interest. EDAT- 2023/03/23 06:00 MHDA- 2023/03/23 06:01 PMCR- 2023/04/13 CRDT- 2023/03/22 12:43 PHST- 2023/03/23 06:01 [medline] PHST- 2023/03/23 06:00 [pubmed] PHST- 2023/03/22 12:43 [entrez] PHST- 2023/04/13 00:00 [pmc-release] AID - 10.1021/acs.langmuir.2c03465 [doi] PST - ppublish SO - Langmuir. 2023 Apr 11;39(14):4984-4992. doi: 10.1021/acs.langmuir.2c03465. Epub 2023 Mar 22. PMID- 30833906 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 10 DP - 2019 TI - Inconsistency in the Standard of Care-Toward Evidence-Based Management of Exertional Heat Stroke. PG - 108 LID - 10.3389/fphys.2019.00108 [doi] LID - 108 AB - Tokyo 2020 Summer Olympics are projected to experience environmental heat stress that surpasses the environmental conditions observed in the Atlanta (1996), Athens (2004), Beijing (2008), and Rio (2016) Summer Olympics. This raises particular concerns for athletes who will likely to be exposed to extreme heat during the competitions. Therefore, in mass-participation event during warm season, it is vital for the hosting organization to build preparedness and resilience against heat, including appropriate treatment, and management strategies for exertional heat stroke (EHS). However, despite the existing literature regarding the evidence-based management of EHS, rectal thermometry and whole-body cold-water immersion are not readily accepted by medical professionals outside of the sports, and military medicine professionals. Current Japanese medical standard is no exception in falling behind on evidence-based management of EHS. Therefore, the first aim of this paper is to elucidate the inconsistency between the standard of care provided in Japan for EHS and what has been accepted as the gold standard by the scientific literature. The second aim of this paper is to provide optimal EHS management strategies that should be implemented at the Tokyo 2020 Summer Olympics from organizational level to maximize the safety of athletes and to improve organizational resilience to heat. The risk of extreme heat is often neglected until a catastrophic incidence occurs. It is vital for the Japanese medical leadership and athletic communities to re-examine the current EHS management strategies and implement evidence-based countermeasure for EHS to expand the application of scientific knowledge. FAU - Hosokawa, Yuri AU - Hosokawa Y AD - College of Sport and Health Science, Ritsumeikan University, Kusatsu, Japan. FAU - Nagata, Takashi AU - Nagata T AD - Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan. FAU - Hasegawa, Manabu AU - Hasegawa M AD - Immunization Office, Health Service Division, Health Service Bureau, Ministry of Health, Labour and Welfare, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20190218 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC6387986 OTO - NOTNLM OT - cold water immersion OT - exertional heat illness OT - exertional heat illness treatment OT - medical control OT - pre-hospital care OT - rectal thermometry EDAT- 2019/03/06 06:00 MHDA- 2019/03/06 06:01 PMCR- 2019/02/18 CRDT- 2019/03/06 06:00 PHST- 2018/11/01 00:00 [received] PHST- 2019/01/28 00:00 [accepted] PHST- 2019/03/06 06:00 [entrez] PHST- 2019/03/06 06:00 [pubmed] PHST- 2019/03/06 06:01 [medline] PHST- 2019/02/18 00:00 [pmc-release] AID - 10.3389/fphys.2019.00108 [doi] PST - epublish SO - Front Physiol. 2019 Feb 18;10:108. doi: 10.3389/fphys.2019.00108. eCollection 2019. PMID- 14727980 OWN - NLM STAT- MEDLINE DCOM- 20040414 LR - 20181025 IS - 1175-3277 (Print) IS - 1175-3277 (Linking) VI - 2 IP - 3 DP - 2002 TI - Naturoceutical agents in the management of cardiovascular disease. PG - 173-96 AB - During the past decade, complementary and alternative medicine (CAM) has grown in attractiveness to the Western public, and in recognition by practitioners of traditional medicine. The incorporation of effective CAM therapies into traditional practice is termed 'integrative medicine'. One form of CAM demonstrating exponential growth through mass public consumerism is the use of naturoceuticals. Naturoceutical (or nutraceutical) agents are defined as mega-dose vitamins, herbal products or other 'natural' supplements purchased and consumed with premeditated 'pharmaceutical' intention to treat or prevent an illness or disease. Dietary supplements per se, are intended to supply adequate nutrients that may be lacking from the diet, and are thus, generally health promoting. A regulatory paradox exists since naturoceuticals are classified as dietary supplements although many possess measurable pharmacologic activity. In reference to cardiovascular disorders, consumers use naturoceuticals for three distinctly recognizable purposes. These are the primary and secondary prevention of cardiovascular diseases and the treatment of diagnosed disorders such as heart failure, angina pectoris or arrhythmia. The evidence base supporting the routine use of naturoceutical products for these intentions is sparse, although the likelihood of harm from their consumption is low for an average, healthy adult. Evidence of significant harm (including fatalities) has been observed when certain herbal products are used in excess or in combination with, other herbs or prescription drugs. The safety of use at the extremes of age, or by persons with cardiac, renal or hepatic impairment is also a concern. Healthcare professionals should routinely document patient naturoceutical use, be alert for and report suspected adverse effects. Until well-designed clinical trials determine the proper indication(s), dose safety profile and risk/benefit ratio for these products, their routine use should not be advocated. Thus, the role of naturoceutical agents in the integrative management of cardiovascular disorders remains undefined. FAU - Hermann, Denise D AU - Hermann DD AD - Heart Failure and Cardiac Transplant Program, University of California at San Diego Medical Center, UCSD Healthcare, San Diego, California 92103-8411, USA. dhermann@ucsd.edu LA - eng PT - Journal Article PT - Review PL - New Zealand TA - Am J Cardiovasc Drugs JT - American journal of cardiovascular drugs : drugs, devices, and other interventions JID - 100967755 RN - 0 (Vitamins) SB - IM MH - Cardiovascular Diseases/prevention & control/*therapy MH - Dietary Supplements/adverse effects MH - Drug Interactions MH - Evidence-Based Medicine MH - Humans MH - *Naturopathy/adverse effects MH - *Phytotherapy/adverse effects MH - Plants, Medicinal/adverse effects/*chemistry MH - Practice Guidelines as Topic MH - Product Surveillance, Postmarketing MH - Vitamins/adverse effects/pharmacology/*therapeutic use RF - 195 EDAT- 2004/01/20 05:00 MHDA- 2004/04/15 05:00 CRDT- 2004/01/20 05:00 PHST- 2004/01/20 05:00 [pubmed] PHST- 2004/04/15 05:00 [medline] PHST- 2004/01/20 05:00 [entrez] AID - 020305 [pii] AID - 10.2165/00129784-200202030-00005 [doi] PST - ppublish SO - Am J Cardiovasc Drugs. 2002;2(3):173-96. doi: 10.2165/00129784-200202030-00005. PMID- 33321301 OWN - NLM STAT- MEDLINE DCOM- 20210127 LR - 20210127 IS - 1879-1700 (Electronic) IS - 0265-931X (Linking) VI - 227 DP - 2021 Feb TI - A novel effect of combining microorganisms and graphene oxide for solidifying simulated nuclides strontium. PG - 106507 LID - S0265-931X(20)30753-0 [pii] LID - 10.1016/j.jenvrad.2020.106507 [doi] AB - Inspired by microbial diagenesis and mounding, microbial mineralization technology has been widely used in the treatment of heavy metal and radionuclide contamination. S. pasteurii can decompose urea as a source of energy to produce CO(3)(2-) in the microbial mineralization system. Therefore, strontium-contaminated radioactive wastewater can be effectively treated by combining CO(3)(2-) with surrounding strontium ions (Sr(2+)) to form strontium carbonate (SrCO(3)). Herein, we investigated how the concentration of graphene oxide (GO) and mineralization time influence the morphology of SrCO(3) and the mineralization efficiency. GO was used as a crystal regulator to solidify the radionuclide strontium in the microbial mineralization system to obtain large-scale rock-like SrCO(3) minerals. The results showed that GO can adsorb the surrounding Sr(2+) with oxygen-containing functional groups on its surface to form SrCO(3) complexes, directly influencing the morphology and consolidation percentage of SrCO(3). Considering the leaching behaviour of nuclides, we further studied the stability of consolidated SrCO(3) minerals. The results indicated that the presence of GO improved the stability of the mineralized samples obtained in the microbial mineralization system. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Zhou, Li AU - Zhou L AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Chen, Tao AU - Chen T AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - He, Guoliang AU - He G AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Jin, Xinglian AU - Jin X AD - Nuclear Power Institute of China, Chengdu, 610041, China. FAU - Liu, Sheng AU - Liu S AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Lian, Jie AU - Lian J AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Yang, Fan AU - Yang F AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Li, Xianyin AU - Li X AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. FAU - Zhang, Jialiang AU - Zhang J AD - Sichuan Jiuzhou Electric Group Co., Ltd., Mianyang, 621010, China. FAU - He, Xinsheng AU - He X AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. Electronic address: hexinsheng@swust.edu.cn. FAU - Zhu, Wenkun AU - Zhu W AD - State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Nuclear Waste and Environmental Safety Key Laboratory of Defense, School of Life Science and Engineering, Joint Laboratory for Extreme Conditions Matter Properties, Southwest University of Science and Technology, Mianyang, 621010, China. Electronic address: zhuwenkun@swust.edu.cn. LA - eng PT - Journal Article DEP - 20201213 PL - England TA - J Environ Radioact JT - Journal of environmental radioactivity JID - 8508119 RN - 0 (Minerals) RN - 0 (graphene oxide) RN - 7782-42-5 (Graphite) RN - YZS2RPE8LE (Strontium) SB - IM MH - *Biodegradation, Environmental MH - Environmental Microbiology MH - *Graphite MH - Minerals MH - *Radiation Monitoring MH - Strontium/chemistry/*metabolism OTO - NOTNLM OT - Graphene oxide OT - Mineralization OT - Sporosarcina pasteurii OT - Strontium carbonate EDAT- 2020/12/16 06:00 MHDA- 2021/01/28 06:00 CRDT- 2020/12/15 20:10 PHST- 2020/07/08 00:00 [received] PHST- 2020/11/21 00:00 [revised] PHST- 2020/12/06 00:00 [accepted] PHST- 2020/12/16 06:00 [pubmed] PHST- 2021/01/28 06:00 [medline] PHST- 2020/12/15 20:10 [entrez] AID - S0265-931X(20)30753-0 [pii] AID - 10.1016/j.jenvrad.2020.106507 [doi] PST - ppublish SO - J Environ Radioact. 2021 Feb;227:106507. doi: 10.1016/j.jenvrad.2020.106507. Epub 2020 Dec 13. PMID- 19964224 OWN - NLM STAT- MEDLINE DCOM- 20100402 LR - 20200928 IS - 2375-7477 (Print) IS - 2375-7477 (Linking) VI - 2009 DP - 2009 TI - Brain-machine interfaces for space applications. PG - 520-3 LID - 10.1109/IEMBS.2009.5333678 [doi] AB - In human space flight, astronauts are the most precious "payload" and astronaut time is extremely valuable. Astronauts operate under unusual and difficult conditions since the absence of gravity makes some of simple tasks tedious and cumbersome. Therefore, computer interfaces for astronauts are generally designed first for safety and then for functionality. In addition to general constraints like mass, volume, robustness, technological solutions need to enhance their functionality and efficiency while not compromising safety. Brain-machine interfaces show promising properties in this respect. It is however not obvious that devices developed for functioning on-ground can be used as hands-free interfaces for astronauts. This paper intends to address the potential of brain-machine interfaces for space applications, to review expected issues related with microgravity effects on brain activities, to highlight those research directions on brain-machine interfaces with the perceived highest potential impact on future space applications, and to embed these into long-term plans with respect to human space flight. We conclude by suggesting research and development steps considered necessary to include brain-machine interface technology in future architectures for human space flight. FAU - Rossini, Luca AU - Rossini L AD - Advanced Concepts Team, European Space Agency, Keplerlaan 1, 2201 AZ Noordwijk, The Netherland. FAU - Izzo, Dario AU - Izzo D FAU - Summerer, Leopold AU - Summerer L LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Brain/*physiology MH - Electroencephalography/*methods MH - Evoked Potentials/*physiology MH - Humans MH - *Man-Machine Systems MH - Space Flight/*methods MH - *User-Computer Interface EDAT- 2009/12/08 06:00 MHDA- 2010/04/03 06:00 CRDT- 2009/12/08 06:00 PHST- 2009/12/08 06:00 [entrez] PHST- 2009/12/08 06:00 [pubmed] PHST- 2010/04/03 06:00 [medline] AID - 10.1109/IEMBS.2009.5333678 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:520-3. doi: 10.1109/IEMBS.2009.5333678. PMID- 2938721 OWN - NLM STAT- MEDLINE DCOM- 19860613 LR - 20041117 IS - 0891-8422 (Print) IS - 0891-8422 (Linking) VI - 3 IP - 2 DP - 1986 Apr TI - Minimal incision surgery. A plastic technique or a cover-up? PG - 321-35 AB - Minimal incision surgery is a plastic surgery technique which requires highly developed, specialized skills. If these techniques are used indiscriminately and/or with underdeveloped skills, the results can be extremely unsatisfactory and the technique itself may become the subject of disrepute. After testing a wide range of applications for 15 years, the authors found a limited number of conditions suitable for correction by MIS techniques. In some cases, however, it allows a somewhat wider range of application than any non-MIS technique. For example, in cases of severe scar formation and compromised vascularity, any other form of surgery could be too traumatic, or, in the elderly, too disabling. Therefore, these techniques can often bring relief with safety to a greater segment of the population than otherwise possible. Benefits are numerous, including certain safety factors. There appears to be an increased protection from scarring, nerve entrapment, infection, pain, and extended disability. Certain cosmetic benefits are also acceptable and attractive to the patient. FAU - Van Enoo, R E AU - Van Enoo RE FAU - Cane, E M AU - Cane EM LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Clin Podiatr Med Surg JT - Clinics in podiatric medicine and surgery JID - 8604974 SB - IM MH - Aged MH - Callosities/surgery MH - Contracture/surgery MH - Female MH - Foot/*surgery MH - Foot Diseases/surgery MH - Hallux Valgus/surgery MH - Humans MH - Male MH - Middle Aged MH - Nail Diseases/surgery MH - Osteotomy/methods MH - Skin Ulcer/surgery MH - Surgery, Plastic/*methods MH - Surgical Instruments MH - Toes/surgery EDAT- 1986/04/01 00:00 MHDA- 1986/04/01 00:01 CRDT- 1986/04/01 00:00 PHST- 1986/04/01 00:00 [pubmed] PHST- 1986/04/01 00:01 [medline] PHST- 1986/04/01 00:00 [entrez] PST - ppublish SO - Clin Podiatr Med Surg. 1986 Apr;3(2):321-35. PMID- 15203443 OWN - NLM STAT- MEDLINE DCOM- 20040907 LR - 20131121 IS - 1355-6215 (Print) IS - 1355-6215 (Linking) VI - 9 IP - 1 DP - 2004 Mar TI - Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature. PG - 81-7 AB - Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers. Some much-quoted early studies noted abnormalities in liver function tests (LFTs) in very obese patients taking high doses, although there was no evidence of clinically significant liver dysfunction. These concerns may be reinforced by advice in the UK product information sheet to perform LFTs before and during treatment, by high infection rates with hepatitis C virus (HCV) among injecting heroin addicts and by the frequency of abnormal LFTs in alcohol abusers. We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant. A decision was made not to remove the implant but the hepatitis resolved completely and uneventfully well within the normal time-scale. A review of the literature indicates that even when given at much higher doses than are needed for treating heroin or alcohol abusers, there is no evidence that NTX causes clinically significant liver disease or exacerbates, even at high doses, serious pre-existing liver disease. During the past decade, NTX has been shown to be safe and effective in the treatment of pruritus associated with severe jaundice caused by severe and sometimes life-threatening cirrhosis and other liver diseases. Its safety, even in these extreme conditions, is particularly reassuring. We suggest that it may be more appropriate and economical to advise patients to report promptly any suspected side effects than to perform regular LFTs, which may be misleading. FAU - Brewer, Colin AU - Brewer C AD - The Stapleford Centre, London, UK. cbrewer@doctors.net.uk FAU - Wong, Voi Shim AU - Wong VS LA - eng PT - Case Reports PT - Journal Article PT - Review PL - United States TA - Addict Biol JT - Addiction biology JID - 9604935 RN - 0 (Delayed-Action Preparations) RN - 0 (Drug Implants) RN - 0 (Narcotic Antagonists) RN - 5S6W795CQM (Naltrexone) SB - IM MH - Acute Disease MH - Adult MH - Delayed-Action Preparations MH - Drug Implants MH - *Hepatitis B/blood/etiology/physiopathology MH - *Hepatitis C/blood/etiology/physiopathology MH - Heroin Dependence/*drug therapy MH - Humans MH - Liver Function Tests MH - Male MH - Naltrexone/administration & dosage/adverse effects/*therapeutic use MH - Narcotic Antagonists/administration & dosage/adverse effects/*therapeutic use RF - 24 EDAT- 2004/06/19 05:00 MHDA- 2004/09/08 05:00 CRDT- 2004/06/19 05:00 PHST- 2004/06/19 05:00 [pubmed] PHST- 2004/09/08 05:00 [medline] PHST- 2004/06/19 05:00 [entrez] AID - D8X9TX390F3W7714 [pii] AID - 10.1080/13556210410001674130 [doi] PST - ppublish SO - Addict Biol. 2004 Mar;9(1):81-7. doi: 10.1080/13556210410001674130. PMID- 15265803 OWN - NLM STAT- MEDLINE DCOM- 20050126 LR - 20181113 IS - 0007-1188 (Print) IS - 0007-1188 (Linking) VI - 142 IP - 8 DP - 2004 Aug TI - Evidence for gender differences in electrophysiological properties of canine Purkinje fibres. PG - 1255-64 AB - Women are more prone to develop torsades de pointes, a rare life-threatening polymorphic ventricular tachycardia, than are men during administration of medicines that have the potential to block I(Kr) (rapid delayed rectifier cardiac K(+) current) and to prolong the QT interval. Blockade of I(Kr), hypokalaemia and extreme bradycardia were used to evaluate whether there are gender differences in cardiac repolarisation in canine Purkinje fibres (PFs). Microelectrode techniques were employed to measure action potential (AP) parameters in PFs from adult female and male dogs. Under control conditions, fibres from female animals in normal or low K(+) conditions exhibited significantly longer AP durations at 50% (APD(50)) and 90% (APD(90)) of repolarisation as compared with APDs of fibres from male animals. Gender-related difference to rate adaptation was also present in APD(90) of fibres from female animals compared to males. At a stimulation rate of 0.2 Hz, but not at 1.0 Hz, dofetilide elicited a significantly higher increase in APD(90), incidence of early afterdepolarisations, triggered and sustained-triggered activities (TAs) in fibres from female animals compared to males in either normal or low K(+) conditions. The sustained TAs were reversed by raising the concentration of [K(+)](0) in Purkinje preparations from both male (one out of one) and female (12 out of 12) dogs. In conclusion, our data provide experimental evidence pointing to gender differences in canine AP repolarisation. PFs from female dogs can be used in safety pharmacology studies as a sensitive model for evaluating the potential proarrhythmic events in vitro of a new medicinal product. FAU - Abi-Gerges, Najah AU - Abi-Gerges N AD - Safety Pharmacology Department, Safety Assessment U.K., AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire SK10 4TG. FAU - Small, Ben G AU - Small BG FAU - Lawrence, Chris L AU - Lawrence CL FAU - Hammond, Tim G AU - Hammond TG FAU - Valentin, Jean-Pierre AU - Valentin JP FAU - Pollard, Chris E AU - Pollard CE LA - eng PT - Comparative Study PT - Journal Article DEP - 20040720 PL - England TA - Br J Pharmacol JT - British journal of pharmacology JID - 7502536 RN - 0 (Phenethylamines) RN - 0 (Sulfonamides) RN - R4Z9X1N2ND (dofetilide) SB - IM MH - Action Potentials/drug effects/physiology MH - Animals MH - Dogs MH - Electrophysiology MH - Female MH - In Vitro Techniques MH - Male MH - Phenethylamines/pharmacology MH - Purkinje Fibers/drug effects/*physiology MH - *Sex Characteristics MH - Sulfonamides/pharmacology PMC - PMC1575188 EDAT- 2004/07/22 05:00 MHDA- 2005/01/27 09:00 PMCR- 2005/08/01 CRDT- 2004/07/22 05:00 PHST- 2004/07/22 05:00 [pubmed] PHST- 2005/01/27 09:00 [medline] PHST- 2004/07/22 05:00 [entrez] PHST- 2005/08/01 00:00 [pmc-release] AID - sj.bjp.0705880 [pii] AID - 10.1038/sj.bjp.0705880 [doi] PST - ppublish SO - Br J Pharmacol. 2004 Aug;142(8):1255-64. doi: 10.1038/sj.bjp.0705880. Epub 2004 Jul 20. PMID- 23106672 OWN - NLM STAT- MEDLINE DCOM- 20130909 LR - 20151119 IS - 1525-1470 (Electronic) IS - 0736-8046 (Linking) VI - 29 IP - 6 DP - 2012 Nov-Dec TI - Quality of life of parents living with a child suffering from atopic dermatitis before and after a 3-month treatment with an emollient. PG - 714-8 LID - 10.1111/j.1525-1470.2012.01817.x [doi] AB - Atopic dermatitis (AD) can be extremely disabling and may cause psychological problems for affected children and their families. Moisturizers and emollients are important in the baseline daily skin care of patients with AD. To assess the effect of a 3-month, twice-daily treatment with an emollient on the quality of life (QoL) of parents with a child with mild to moderate AD (SCORing Atopic Dermatitis [SCORAD] ≤ 30, a multicenter open trial was performed by eight dermatologists on 191 volunteers. Evaluation by the dermatologist of the child's clinical condition (SCORAD) and of the efficacy and overall safety of the treatment was associated with a QoL questionnaire completed by one parent of the atopic child. A self-assessment of the global QoL and of the efficacy and overall safety was also performed. During the study, mean SCORAD dropped from 28 to 12 (p < 0.001), with good improvement in skin dryness and pruritus criteria. At the same time, the self-assessment of the global parent QoL scores dropped from 4.4 to 2.1 (p < 0.001) with 60%, 48% and 79% favorable parent opinions regarding wellbeing or improvement of the health condition, quality of sleep, and efficacy of the emollient, respectively. This trial revealed the efficacy of the product in improving parent QoL (85% of parents noted improvement in QoL), and its global safety was considered to be very good or good, with 80% favorable opinions in parents' declarative judgements and dermatologists' assessments. The emollient evaluated improves the course of AD and can improve the QoL of patients and their families. CI - © 2012 Wiley Periodicals, Inc. FAU - Gelmetti, Carlo AU - Gelmetti C AD - Scienze Dermatologiche, Università degli Studi di Milano, Fondazione IRCSS Ospedale Maggiore Policlinico, Milan, Italy. carlo.gelmetti@unimi.it FAU - Boralevi, Franck AU - Boralevi F FAU - Seité, Sophie AU - Seité S FAU - Grimalt, Ramon AU - Grimalt R FAU - Humbert, Philippe AU - Humbert P FAU - Luger, Thomas AU - Luger T FAU - Stalder, Jean-Francois AU - Stalder JF FAU - Taïeb, Alain AU - Taïeb A FAU - Tennstedt, Dominique AU - Tennstedt D FAU - Garcia Diaz, Rita AU - Garcia Diaz R FAU - Rougier, André AU - Rougier A LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PL - United States TA - Pediatr Dermatol JT - Pediatric dermatology JID - 8406799 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Emollients) RN - 0 (Oleic Acids) RN - 0 (Plant Oils) RN - 0 (shea oleine) SB - IM MH - Administration, Topical MH - Adrenal Cortex Hormones/administration & dosage MH - Adult MH - Child MH - Child, Preschool MH - Dermatitis, Atopic/*drug therapy/*psychology MH - Emollients/*administration & dosage MH - *Family Health MH - Female MH - Humans MH - Infant MH - Male MH - Oleic Acids/*administration & dosage MH - Parent-Child Relations MH - Plant Oils/*administration & dosage MH - Quality of Life/*psychology MH - Severity of Illness Index MH - Surveys and Questionnaires MH - Treatment Outcome EDAT- 2012/10/31 06:00 MHDA- 2013/09/10 06:00 CRDT- 2012/10/31 06:00 PHST- 2012/10/31 06:00 [entrez] PHST- 2012/10/31 06:00 [pubmed] PHST- 2013/09/10 06:00 [medline] AID - 10.1111/j.1525-1470.2012.01817.x [doi] PST - ppublish SO - Pediatr Dermatol. 2012 Nov-Dec;29(6):714-8. doi: 10.1111/j.1525-1470.2012.01817.x. PMID- 39409227 OWN - NLM STAT- MEDLINE DCOM- 20241016 LR - 20241019 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 19 DP - 2024 Sep 24 TI - Monocular 3D Multi-Person Pose Estimation for On-Site Joint Flexion Assessment: A Case of Extreme Knee Flexion Detection. LID - 10.3390/s24196187 [doi] LID - 6187 AB - Work-related musculoskeletal disorders (WMSDs) represent a significant health challenge for workers in construction environments, often arising from prolonged exposure to ergonomic risks associated with manual labor, awkward postures, and repetitive motions. These conditions not only lead to diminished worker productivity but also incur substantial economic costs for employers and healthcare systems alike. Thus, there is an urgent need for effective tools to assess and mitigate these ergonomic risks. This study proposes a novel monocular 3D multi-person pose estimation method designed to enhance ergonomic risk assessments in construction environments. Leveraging advanced computer vision and deep learning techniques, this approach accurately captures and analyzes the spatial dynamics of workers' postures, with a focus on detecting extreme knee flexion, a critical indicator of work-related musculoskeletal disorders (WMSDs). A pilot study conducted on an actual construction site demonstrated the method's feasibility and effectiveness, achieving an accurate detection rate for extreme flexion incidents that closely aligned with supervisory observations and worker self-reports. The proposed monocular approach enables universal applicability and enhances ergonomic analysis through 3D pose estimation and group pose recognition for timely interventions. Future efforts will focus on improving robustness and integration with health monitoring to reduce WMSDs and promote worker health. FAU - Yan, Guihai AU - Yan G AD - Central Research Institute of Building and Construction Co., Ltd., MCC Group, Shenzhen 518088, China. FAU - Yan, Haofeng AU - Yan H AUID- ORCID: 0009-0004-7671-7136 AD - School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China. FAU - Yao, Zhidong AU - Yao Z AD - Central Research Institute of Building and Construction Co., Ltd., MCC Group, Shenzhen 518088, China. FAU - Lin, Zhongliang AU - Lin Z AD - Central Research Institute of Building and Construction Co., Ltd., MCC Group, Shenzhen 518088, China. FAU - Wang, Gang AU - Wang G AD - China Jingye Engineering Technology, Co., Ltd., Shenzhen 518055, China. FAU - Liu, Changyong AU - Liu C AD - School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China. FAU - Yang, Xincong AU - Yang X AD - School of Civil and Environmental Engineering, Harbin Institute of Technology, Shenzhen 518055, China. AD - Guangdong Provincial Key Laboratory of Intelligent and Resilient Structures for Civil Engineering, Shenzhen 518055, China. LA - eng GR - 52108286/National Natural Science Foundation of China/ GR - GXWD20220818002513001/Shenzhen Science and Technology Programs/ GR - RCBS20221008093128076/Shenzhen Science and Technology Programs/ GR - ZDSYS20210929115800001/Shenzhen Science and Technology Programs/ PT - Journal Article DEP - 20240924 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Posture/physiology MH - *Ergonomics/methods MH - Knee Joint/physiology MH - Range of Motion, Articular/physiology MH - Imaging, Three-Dimensional/methods MH - Musculoskeletal Diseases/diagnosis/physiopathology MH - Male MH - Pilot Projects PMC - PMC11478384 OTO - NOTNLM OT - 3D pose estimation OT - computer vision OT - construction safety OT - deep learning OT - ergonomic risk assessment OT - multi-person COIS- Author Guihai Yan, Zhidong Yao and Zhongliang Lin was employed by the company Central Research Institute of Building and Construction Co., Ltd. Author Gang Wang was employed by the company China Jingye Engineering Technology, Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/10/16 10:18 MHDA- 2024/10/16 10:19 PMCR- 2024/09/24 CRDT- 2024/10/16 01:11 PHST- 2024/09/13 00:00 [received] PHST- 2024/09/22 00:00 [revised] PHST- 2024/09/23 00:00 [accepted] PHST- 2024/10/16 10:19 [medline] PHST- 2024/10/16 10:18 [pubmed] PHST- 2024/10/16 01:11 [entrez] PHST- 2024/09/24 00:00 [pmc-release] AID - s24196187 [pii] AID - sensors-24-06187 [pii] AID - 10.3390/s24196187 [doi] PST - epublish SO - Sensors (Basel). 2024 Sep 24;24(19):6187. doi: 10.3390/s24196187. PMID- 32369328 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200611 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 12 IP - 23 DP - 2020 Jun 10 TI - High Modulus, Thermally Stable, and Self-Extinguishing Aramid Nanofiber Separators. PG - 25756-25766 LID - 10.1021/acsami.0c03671 [doi] AB - Mechanically and thermally robust separators offer an alternative approach for preventing battery failure under extreme conditions such as high loads and temperatures. However, the trade-off between electrochemical performance and mechanical and thermal stability remains an ongoing challenge. Here, we investigate aramid nanofiber (ANF) separators that possess high moduli and self-extinguishing characteristics. The ANF separators are formed from the dissolution of bulk Kevlar fibers and their subsequent vacuum-assisted self-assembly. Thermogravimetric analysis shows a high 5 wt % decomposition temperature of 447 °C, which is over ∼175 °C higher than commercial Celgard separators. The ANF separator also possesses a high Young's modulus of 8.8 GPa, which is ∼1000% higher than commercial separators. Even when dry or when soaked in battery electrolyte, the ANF separators self-extinguish upon exposure to flame, whereas commercial separators melt or drip. We show that these features, although adventitious, present a trade-off with electrochemical performance in which a lithium nickel manganse cobalt (NMC) oxide-based battery possessed a reduced capacity of 123.4 mA h g(-1). Considering the separator holistically, we propose that the ANF separator shows an excellent balance of the combined properties of high modulus, flame-resistance, thermal stability, and electrochemical stability and might be suitable for extreme environment applications with further testing. FAU - Patel, Anish AU - Patel A AD - Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States. FAU - Wilcox, Kathryn AU - Wilcox K AD - Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States. FAU - Li, Zhuo AU - Li Z AUID- ORCID: 0000-0002-8830-9891 AD - Department of Chemical Engineering, University of Rochester, Rochester, New York 14627, United States. FAU - George, Ian AU - George I AD - Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States. FAU - Juneja, Rishabh AU - Juneja R AD - Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States. FAU - Lollar, Christina AU - Lollar C AUID- ORCID: 0000-0002-1631-4739 AD - Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States. FAU - Lazar, Simone AU - Lazar S AD - Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States. FAU - Grunlan, Jaime AU - Grunlan J AUID- ORCID: 0000-0001-5241-9741 AD - Department of Materials Science and Engineering, Texas A&M University, College Station, Texas 77843, United States. AD - Department of Mechanical Engineering, Texas A&M University, College Station, Texas 77843, United States. FAU - Tenhaeff, Wyatt E AU - Tenhaeff WE AUID- ORCID: 0000-0001-7132-3171 AD - Department of Chemical Engineering, University of Rochester, Rochester, New York 14627, United States. FAU - Lutkenhaus, Jodie L AU - Lutkenhaus JL AUID- ORCID: 0000-0002-2613-6016 AD - Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States. AD - Department of Materials Science and Engineering, Texas A&M University, College Station, Texas 77843, United States. LA - eng PT - Journal Article DEP - 20200601 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - Li-ion battery OT - aramid OT - nanofibers OT - safety OT - separators EDAT- 2020/05/06 06:00 MHDA- 2020/05/06 06:01 CRDT- 2020/05/06 06:00 PHST- 2020/05/06 06:00 [pubmed] PHST- 2020/05/06 06:01 [medline] PHST- 2020/05/06 06:00 [entrez] AID - 10.1021/acsami.0c03671 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2020 Jun 10;12(23):25756-25766. doi: 10.1021/acsami.0c03671. Epub 2020 Jun 1. PMID- 19732392 OWN - NLM STAT- MEDLINE DCOM- 20091127 LR - 20090923 IS - 1539-6924 (Electronic) IS - 0272-4332 (Linking) VI - 29 IP - 10 DP - 2009 Oct TI - Risk analysis of the vessel traffic in the strait of istanbul. PG - 1454-72 LID - 10.1111/j.1539-6924.2009.01287.x [doi] AB - The Strait of Istanbul, the narrow waterway separating Europe from Asia, holds a strategic importance in maritime transportation as it links the Black Sea to the Mediterranean. It is considered as one of the world's most congested and difficult-to-navigate waterways. Over 55,000 transit vessels pass through the Strait annually, roughly 20% of which carry dangerous cargo. In this study, we have analyzed safety risks pertaining to transit vessel maritime traffic in the Strait of Istanbul and proposed ways to mitigate them. Safety risk analysis was performed by incorporating a probabilistic accident risk model into the simulation model. A mathematical risk model was developed based on probabilistic arguments regarding instigators, situations, accidents, consequences, and historical data, as well as subject-matter expert opinions. Scenario analysis was carried out to study the behavior of the accident risks, with respect to changes in the surrounding geographical, meteorological, and traffic conditions. Our numerical investigations suggested some significant policy indications. Local traffic density and pilotage turned out to be two main factors affecting the risks at the Strait of Istanbul. Results further indicate that scheduling changes to allow more vessels into the Strait will increase risks to extreme levels. Conversely, scheduling policy changes that are opted to reduce risks may cause major increases in average vessel waiting times. This in turn signifies that the current operations at the Strait of Istanbul have reached a critical level beyond which both risks and vessel delays are unacceptable. FAU - Ulusçu, Ozgecan S AU - Ulusçu OS AD - CAIT-DIMACS Laboratory for Port Security, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. FAU - Ozbaş, Birnur AU - Ozbaş B FAU - Altiok, Tayfur AU - Altiok T FAU - Or, Ilhan AU - Or I LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20090902 PL - United States TA - Risk Anal JT - Risk analysis : an official publication of the Society for Risk Analysis JID - 8109978 SB - IM MH - Risk Assessment MH - *Transportation MH - Turkey EDAT- 2009/09/08 06:00 MHDA- 2009/12/16 06:00 CRDT- 2009/09/08 06:00 PHST- 2009/09/08 06:00 [entrez] PHST- 2009/09/08 06:00 [pubmed] PHST- 2009/12/16 06:00 [medline] AID - RISK1287 [pii] AID - 10.1111/j.1539-6924.2009.01287.x [doi] PST - ppublish SO - Risk Anal. 2009 Oct;29(10):1454-72. doi: 10.1111/j.1539-6924.2009.01287.x. Epub 2009 Sep 2. PMID- 25079039 OWN - NLM STAT- MEDLINE DCOM- 20150305 LR - 20171116 IS - 1744-7658 (Electronic) IS - 1354-3784 (Linking) VI - 23 IP - 9 DP - 2014 Sep TI - Gevokizumab in type 1 diabetes mellitus: extreme remedies for extreme diseases? PG - 1277-84 LID - 10.1517/13543784.2014.947026 [doi] AB - INTRODUCTION: Insulin is the cornerstone of type 1 diabetes mellitus (T1DM) therapy. However, it cannot achieve a delay in the onset or evolution of this condition, while cardiovascular morbidity remains an unquestionable threat. AREAS COVERED: In this review, the authors discuss gevokizumab (XOMA 052), a recombinant monoclonal antibody that can neutralize human IL-1β by binding to it. This is relevant, because this IL has been associated with β-cell toxicity in both diabetes types. Moreover, gevokizumab presents two major advantages: it spares IL-1α and it exhibits favorable pharmacokinetic properties. Gevokizumab has already proven its safety and efficacy in improving glycemic control, β cell function and inflammation markers in clinical trials in diabetic patients. EXPERT OPINION: Despite the very promising characteristics of gevokizumab, important questions remain to be answered. One important question is what to expect from a combination of this agent with insulin and if there is a subset of patients that might respond more favorably to treatment. We also need to know at what stage in the natural history of T1DM could gevokizumab be most efficacious, as well as its potential effects on cardiovascular outcomes. FAU - Pafili, Kalliopi AU - Pafili K AD - Diabetes Clinic, Democritus University of Thrace, University Hospital of Alexandroupolis, Second Department of Internal Medicine , G. Kondyli 22c, Alexandroupolis 68100 , Greece +30 2551074713 ; +30 25510 74723 ; papanasnikos@yahoo.gr. FAU - Papanas, Nikolaos AU - Papanas N FAU - Maltezos, Efstratios AU - Maltezos E LA - eng PT - Journal Article PT - Review DEP - 20140731 PL - England TA - Expert Opin Investig Drugs JT - Expert opinion on investigational drugs JID - 9434197 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 0 (Blood Glucose) RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) RN - 0 (Interleukin-1beta) RN - QX3JU54GYQ (gevokizumab) SB - IM MH - Animals MH - Antibodies, Monoclonal, Humanized/adverse effects/pharmacology/*therapeutic use MH - Blood Glucose/drug effects MH - Diabetes Mellitus, Type 1/*drug therapy/physiopathology MH - Humans MH - Hypoglycemic Agents/adverse effects/*therapeutic use MH - Insulin/therapeutic use MH - Insulin-Secreting Cells/metabolism MH - Interleukin-1beta/immunology OTO - NOTNLM OT - IL-1β OT - gevokizumab OT - inflammation OT - type 1 diabetes EDAT- 2014/08/01 06:00 MHDA- 2015/03/07 06:00 CRDT- 2014/08/01 06:00 PHST- 2014/08/01 06:00 [entrez] PHST- 2014/08/01 06:00 [pubmed] PHST- 2015/03/07 06:00 [medline] AID - 10.1517/13543784.2014.947026 [doi] PST - ppublish SO - Expert Opin Investig Drugs. 2014 Sep;23(9):1277-84. doi: 10.1517/13543784.2014.947026. Epub 2014 Jul 31. PMID- 35600109 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240826 IS - 2234-5248 (Electronic) IS - 2234-778X (Print) VI - 24 IP - 3 DP - 2021 Sep 15 TI - Is cholecystectomy safe in extremely elderly patients? PG - 126-127 LID - 10.7602/jmis.2021.24.3.126 [doi] AB - Gallstone disease is the most common global indication for abdominal surgery. Especially acute cholecystitis in the elderly is frequently encountered due to an increasingly elderly population. Although cholecystectomy is the gold standard treatment for acute cholecystitis, the surgical management in the elderly presents specific challenges due to associated comorbidities, the severity of their presenting disease, and a greater likelihood of suffering postoperative complications and prolonged hospital stay. Further effort to provide firm evidence to clarify the safety and feasibility of cholecystectomy for acute cholecystitis in extremely elderly patients such as octogenarians and even nonagenarians. CI - Copyright © 2021 The Journal of Minimally Invasive Surgery. All rights reserved. FAU - Yang, Jae Do AU - Yang JD AUID- ORCID: 0000-0001-9701-7666 AD - Department of Surgery, Jeonbuk National University Hospital, Jeonbuk National University Medical School, Jeonju, Korea. LA - eng PT - Editorial PL - Korea (South) TA - J Minim Invasive Surg JT - Journal of minimally invasive surgery JID - 101585410 PMC - PMC8977385 OTO - NOTNLM OT - Acute cholecystitis OT - Cholecystectomy OT - Octogenarians COIS- The author has no conflicts of interest to declare. EDAT- 2022/05/24 06:00 MHDA- 2022/05/24 06:01 PMCR- 2021/09/15 CRDT- 2022/05/23 03:48 PHST- 2021/08/22 00:00 [received] PHST- 2021/09/10 00:00 [revised] PHST- 2021/09/11 00:00 [accepted] PHST- 2022/05/23 03:48 [entrez] PHST- 2022/05/24 06:00 [pubmed] PHST- 2022/05/24 06:01 [medline] PHST- 2021/09/15 00:00 [pmc-release] AID - jmis-24-3-126 [pii] AID - 10.7602/jmis.2021.24.3.126 [doi] PST - ppublish SO - J Minim Invasive Surg. 2021 Sep 15;24(3):126-127. doi: 10.7602/jmis.2021.24.3.126. PMID- 24697679 OWN - NLM STAT- MEDLINE DCOM- 20150330 LR - 20240322 IS - 1365-3040 (Electronic) IS - 0140-7791 (Print) IS - 0140-7791 (Linking) VI - 37 IP - 9 DP - 2014 Sep TI - Static and dynamic bending has minor effects on xylem hydraulics of conifer branches (Picea abies, Pinus sylvestris). PG - 2151-7 LID - 10.1111/pce.12307 [doi] AB - The xylem hydraulic efficiency and safety is usually measured on mechanically unstressed samples, although trees may be exposed to combined hydraulic and mechanical stress in the field. We analysed changes in hydraulic conductivity and vulnerability to drought-induced embolism during static bending of Picea abies and Pinus sylvestris branches as well as the effect of dynamic bending on the vulnerability. We hypothesized this mechanical stress to substantially impair xylem hydraulics. Intense static bending caused an only small decrease in hydraulic conductance (-19.5 ± 2.4% in P. abies) but no shift in vulnerability thresholds. Dynamic bending caused a 0.4 and 0.8 MPa decrease of the water potential at 50 and 88% loss of conductivity in P. sylvestris, but did not affect vulnerability thresholds in P. abies. With respect to applied extreme bending radii, effects on plant hydraulics were surprisingly small and are thus probably of minor eco-physiological importance. More importantly, results indicate that available xylem hydraulic analyses (of conifers) sufficiently reflect plant hydraulics under field conditions. CI - © 2014 The Authors. Plant, Cell & Environment published by John Wiley & Sons Ltd. FAU - Mayr, Stefan AU - Mayr S AD - Department of Botany, University of Innsbruck, Sternwartestr. 15, A-6020, Innsbruck, Austria. FAU - Bertel, Clara AU - Bertel C FAU - Dämon, Birgit AU - Dämon B FAU - Beikircher, Barbara AU - Beikircher B LA - eng GR - I 826/FWF_/Austrian Science Fund FWF/Austria GR - P 20852/FWF_/Austrian Science Fund FWF/Austria PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140320 PL - United States TA - Plant Cell Environ JT - Plant, cell & environment JID - 9309004 RN - 059QF0KO0R (Water) SB - IM MH - Austria MH - Droughts MH - Pinus/*physiology MH - Pinus sylvestris/*physiology MH - Plant Stems/*physiology MH - *Stress, Physiological MH - Water/*physiology MH - Xylem/*physiology PMC - PMC4312774 OTO - NOTNLM OT - hydraulic efficiency OT - hydraulic safety OT - hydraulics OT - mechanics OT - vulnerability to embolism EDAT- 2014/04/05 06:00 MHDA- 2015/03/31 06:00 CRDT- 2014/04/05 06:00 PHST- 2013/12/03 00:00 [received] PHST- 2014/02/06 00:00 [revised] PHST- 2014/02/08 00:00 [accepted] PHST- 2014/04/05 06:00 [entrez] PHST- 2014/04/05 06:00 [pubmed] PHST- 2015/03/31 06:00 [medline] AID - 10.1111/pce.12307 [doi] PST - ppublish SO - Plant Cell Environ. 2014 Sep;37(9):2151-7. doi: 10.1111/pce.12307. Epub 2014 Mar 20. PMID- 13678136 OWN - NLM STAT- MEDLINE DCOM- 20040224 LR - 20091119 IS - 0002-838X (Print) IS - 0002-838X (Linking) VI - 68 IP - 5 DP - 2003 Sep 1 TI - Failure to thrive. PG - 879-84 AB - Failure to thrive is a condition commonly seen by primary care physicians. Prompt diagnosis and intervention are important for preventing malnutrition and developmental sequelae. Medical and social factors often contribute to failure to thrive. Either extreme of parental attention (neglect or hypervigilance) can lead to failure to thrive. About 25 percent of normal infants will shift to a lower growth percentile in the first two years of life and then follow that percentile; this should not be diagnosed as failure to thrive. Infants with Down syndrome, intrauterine growth retardation, or premature birth follow different growth patterns than normal infants. Many infants with failure to thrive are not identified unless careful attention is paid to plotting growth parameters at routine checkups. A thorough history is the best guide to establishing the etiology of the failure to thrive and directing further evaluation and management. All children with failure to thrive need additional calories for catch-up growth (typically 150 percent of the caloric requirement for their expected, not actual, weight). Few need laboratory evaluation. Hospitalization is rarely required and is indicated only for severe failure to thrive and for those whose safety is a concern. A multidisciplinary approach is recommended when failure to thrive persists despite intervention or when it is severe. FAU - Krugman, Scott D AU - Krugman SD AD - Department of Pediatrics, Franklin Square Hospital Center, Baltimore, Maryland 21237, USA. scott.krugman@medstar.net FAU - Dubowitz, Howard AU - Dubowitz H LA - eng PT - Journal Article PT - Review PL - United States TA - Am Fam Physician JT - American family physician JID - 1272646 SB - IM CIN - Am Fam Physician. 2003 Sep 1;68(5):886. PMID: 13678137 MH - Child MH - Child Nutritional Physiological Phenomena MH - Child, Preschool MH - Diagnosis, Differential MH - Diet Records MH - *Energy Intake MH - Failure to Thrive/*diagnosis/diet therapy/etiology MH - Humans MH - Infant MH - *Parent-Child Relations MH - Referral and Consultation MH - Stress, Psychological RF - 26 EDAT- 2003/09/19 05:00 MHDA- 2004/02/26 05:00 CRDT- 2003/09/19 05:00 PHST- 2003/09/19 05:00 [pubmed] PHST- 2004/02/26 05:00 [medline] PHST- 2003/09/19 05:00 [entrez] PST - ppublish SO - Am Fam Physician. 2003 Sep 1;68(5):879-84. PMID- 36932170 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230320 LR - 20230320 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Mar 17 TI - Fuzzy optimal control of multilayer coverage based on radon exhalation dynamics in uranium tailings. PG - 4414 LID - 10.1038/s41598-023-31518-7 [doi] LID - 4414 AB - Radon exhalation from uranium tailings has seriously affected environmental safety and human health. Many uncertain parameters, such as diffusion coefficient, porosity, percolation rate, material particle size, etc., are related to the diffusion and migration of radon. Moreover, cover materials, cover layers, and cover thickness are the main instruments to control radon exhalation, and the radon reduction effect of single-layer mulching is often inferior to that of the multilayer. Hence, achieving radon control with multilayer coverage under uncertain environment is an urgent problem that must be solved in the area of nuclear safety and radiation environment. In an attempt to address the issue, a dynamic model of radon exhalation with multilayer coverage is constructed using radon percolation-diffusion migration equation, and triangular membership functions inscribe the model parameters; the objective functions of the left and right equations of the model are constructed, and their extreme value intervals are obtained using immunogenetic algorithm. Then, subject to the total cost and thickness of multilayer covering materials, the fuzzy objective and constraint models of radon exhalation are constructed, and the fuzzy aggregation function is reconstructed according to the importance of the fuzzy objective and constraint models, where ultimately, the optimal radon control decision by swarm intelligence algorithm under different possibility levels and importance conditions can be obtained. An example is then used to validate the effectiveness of the radon exhalation model, and to demonstrate that fuzzy optimization provides a database of decision-making schemes regarding multilayer coverage, and guidance for optimal control and flexible construction management. CI - © 2023. The Author(s). FAU - Zhang, Meirong AU - Zhang M AD - School of Resource Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China. AD - Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, 421001, Hunan, China. FAU - Dai, Jianyong AU - Dai J AD - School of Resource Environment and Safety Engineering, University of South China, Hengyang, 421001, Hunan, China. daijy13@163.com. AD - Key Laboratory of Emergency Safety Technology and Equipment of Nuclear Facilities in Hunan Province, Hengyang, 421001, Hunan, China. daijy13@163.com. LA - eng GR - 51174116/National Natural Science Foundation of China/ PT - Journal Article DEP - 20230317 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC10023809 COIS- The authors declare no competing interests. EDAT- 2023/03/19 06:00 MHDA- 2023/03/19 06:01 PMCR- 2023/03/17 CRDT- 2023/03/18 00:20 PHST- 2022/07/05 00:00 [received] PHST- 2023/03/13 00:00 [accepted] PHST- 2023/03/18 00:20 [entrez] PHST- 2023/03/19 06:00 [pubmed] PHST- 2023/03/19 06:01 [medline] PHST- 2023/03/17 00:00 [pmc-release] AID - 10.1038/s41598-023-31518-7 [pii] AID - 31518 [pii] AID - 10.1038/s41598-023-31518-7 [doi] PST - epublish SO - Sci Rep. 2023 Mar 17;13(1):4414. doi: 10.1038/s41598-023-31518-7. PMID- 32282992 OWN - NLM STAT- MEDLINE DCOM- 20200910 LR - 20230124 IS - 1600-6143 (Electronic) IS - 1600-6135 (Print) IS - 1600-6135 (Linking) VI - 20 IP - 9 DP - 2020 Sep TI - Coronavirus disease 2019: Utilizing an ethical framework for rationing absolutely scarce health-care resources in transplant allocation decisions. PG - 2332-2336 LID - 10.1111/ajt.15914 [doi] AB - The novel coronavirus disease 2019 (COVID-19) is impacting transplant programs around the world, and, as the center of the pandemic shifts to the United States, we have to prepare to make decisions about which patients to transplant during times of constrained resources. In this paper, we discuss how to transition from the traditional justice versus utility consideration in organ allocation to a more nuanced allocation scheme based on ethical values that drive decisions in times of absolute scarcity. We recognize that many decisions are made based on the practical limitations that transplant programs face, especially at the extremes. As programs make the transition from a standard approach to a resource-constrained approach to transplantation, we utilize a framework for ethical decisions in settings of absolutely scarce resources to help guide programs in deciding which patients to transplant, which donors to accept, how to minimize risk, and how to ensure the best utilization of transplant team members. CI - © 2020 The American Society of Transplantation and the American Society of Transplant Surgeons. FAU - Wall, Anji E AU - Wall AE AUID- ORCID: 0000-0002-7359-1337 AD - Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas. FAU - Pruett, Timothy AU - Pruett T AUID- ORCID: 0000-0002-0715-8535 AD - Division of Transplantation, University of Minnesota, Minneapolis, Minnesota. FAU - Stock, Peter AU - Stock P AUID- ORCID: 0000-0002-5806-0167 AD - Division of Transplant Surgery, University of California San Francisco, San Francisco, California. FAU - Testa, Giuliano AU - Testa G AD - Annette C. and Harold C. Simmons Transplant Institute, Baylor University Medical Center, Dallas, Texas. LA - eng PT - Journal Article PT - Review DEP - 20200426 PL - United States TA - Am J Transplant JT - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JID - 100968638 SB - IM MH - *Betacoronavirus MH - COVID-19 MH - Coronavirus Infections/*epidemiology MH - Health Care Rationing/*organization & administration MH - Health Resources/*statistics & numerical data MH - Humans MH - Organ Transplantation/*statistics & numerical data MH - Pandemics MH - Patient Selection MH - Pneumonia, Viral/*epidemiology MH - Resource Allocation/*methods MH - SARS-CoV-2 PMC - PMC7262060 OTO - NOTNLM OT - editorial/personal viewpoint OT - ethics OT - ethics and public policy OT - infection and infectious agents - viral OT - infectious disease OT - organ acceptance OT - organ allocation OT - organ procurement and allocation OT - organ transplantation in general OT - patient safety EDAT- 2020/04/14 06:00 MHDA- 2020/09/12 06:00 PMCR- 2022/12/30 CRDT- 2020/04/14 06:00 PHST- 2020/03/29 00:00 [received] PHST- 2020/04/03 00:00 [revised] PHST- 2020/04/06 00:00 [accepted] PHST- 2020/04/14 06:00 [pubmed] PHST- 2020/09/12 06:00 [medline] PHST- 2020/04/14 06:00 [entrez] PHST- 2022/12/30 00:00 [pmc-release] AID - S1600-6135(22)22551-9 [pii] AID - 10.1111/ajt.15914 [doi] PST - ppublish SO - Am J Transplant. 2020 Sep;20(9):2332-2336. doi: 10.1111/ajt.15914. Epub 2020 Apr 26. PMID- 22279772 OWN - NLM STAT- MEDLINE DCOM- 20120406 LR - 20161020 IS - 0869-8031 (Print) IS - 0869-8031 (Linking) VI - 51 IP - 5 DP - 2011 Sep-Oct TI - [Problems of ensuring human radiation safety during interplanetary flights]. PG - 595-610 AB - The work contains the analyses and discussion of the main sources of space radiation specified for interplanetary flights, the dosimetric functionals used for describing the processes of radiation lesions and reparation of the organism in the conditions of the complex radiation impact with a broad charge composition of cosmic rays and a peculiar spatial and temporal dose behavior. It represents the results of calculations of the radiation risks during the flight and the total lifelong radiation risk with taking into account all the delayed unfavorable biological consequences. The main uncertainties in the calculated values of radiation risk leading to its undervaluation are analyzed. In addition, also provided is the range of theoretical and experimental investigations necessary for the adjustment of coefficient values used in the algorithm of radiation risk calculations, as well as in the nomenclature of experiments for estimating the individual resistance of man to the extreme influence and investigations aimed at estimating and increasing the reliability of the operator activity of cosmonauts. FAU - Ushakov, I B AU - Ushakov IB FAU - Petrov, V M AU - Petrov VM FAU - Shafirkin, A V AU - Shafirkin AV FAU - Shtemberg, A S AU - Shtemberg AS LA - rus PT - English Abstract PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Russia (Federation) TA - Radiats Biol Radioecol JT - Radiatsionnaia biologiia, radioecologiia JID - 9317212 SB - IM MH - Age Factors MH - Astronauts MH - *Cosmic Radiation MH - Humans MH - Models, Theoretical MH - Radiation Dosage MH - Radiation Protection/*methods/standards MH - Risk Assessment MH - Risk Factors MH - *Solar Energy MH - *Space Flight EDAT- 2012/01/28 06:00 MHDA- 2012/04/07 06:00 CRDT- 2012/01/28 06:00 PHST- 2012/01/28 06:00 [entrez] PHST- 2012/01/28 06:00 [pubmed] PHST- 2012/04/07 06:00 [medline] PST - ppublish SO - Radiats Biol Radioecol. 2011 Sep-Oct;51(5):595-610. PMID- 27826288 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 7 DP - 2016 TI - Temperature Exerts Control of Bacillus cereus Emetic Toxin Production on Post-transcriptional Levels. PG - 1640 LID - 1640 AB - In recent years, the emetic toxin cereulide, produced by Bacillus cereus, has gained high relevance in food production and food safety. Cereulide is synthesized non-ribosomal by the multi-enzyme complex Ces-NRPS, which is encoded on a megaplasmid that shares its backbone with the Bacillus anthracis pX01 toxin plasmid. Due to its resistance against heat, proteolysis and extreme pH conditions, the formation of this highly potent depsipeptide toxin is of serious concern in food processing procedures including slow cooling procedures and/or storage of intermediate products at ambient temperatures. So far, systematic data on the effect of extrinsic factors on cereulide synthesis has been lacking. Thus, we investigated the influence of temperature, a central extrinsic parameter in food processing, on the regulation of cereulide synthesis on transcriptional, translational and post-translational levels over the growth temperature range of emetic B. cereus. Bacteria were grown in 3°C interval steps from 12 to 46°C and cereulide synthesis was followed from ces gene transcription to cereulide toxin production. This systematic study revealed that temperature is a cardinal parameter, which primarily impacts cereulide synthesis on post-transcriptional levels, thereby altering the composition of cereulide isoforms. Our work also highlights that the risk of cereulide production could not be predicted from growth parameters or sole cell numbers. Furthermore, for the first time we could show that the formation of the recently identified cereulide isoforms is highly temperature dependent, which may have great importance in terms of food safety and predictive microbiology. Notably the production of isocereulide A, which is about 10-fold more cytotoxic than cereulide, was specifically supported at low temperatures. FAU - Kranzler, Markus AU - Kranzler M AD - Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine Vienna Vienna, Austria. FAU - Stollewerk, Katharina AU - Stollewerk K AD - Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine Vienna Vienna, Austria. FAU - Rouzeau-Szynalski, Katia AU - Rouzeau-Szynalski K AD - Food Safety Microbiology, Nestec Ltd, Nestlé Research Center Lausanne, Switzerland. FAU - Blayo, Laurence AU - Blayo L AD - Food Safety Microbiology, Nestec Ltd, Nestlé Research Center Lausanne, Switzerland. FAU - Sulyok, Michael AU - Sulyok M AD - Center for Analytical Chemistry, Department of Agrobiotechnology, IFA Tulln, University of Natural Resources and Life Sciences Vienna (BOKU) Vienna, Austria. FAU - Ehling-Schulz, Monika AU - Ehling-Schulz M AD - Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine Vienna Vienna, Austria. LA - eng PT - Journal Article DEP - 20161025 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC5078297 OTO - NOTNLM OT - Bacillus cereus OT - cereulide OT - food safety OT - isocereulide OT - temperature EDAT- 2016/11/09 06:00 MHDA- 2016/11/09 06:01 PMCR- 2016/10/25 CRDT- 2016/11/10 06:00 PHST- 2016/06/26 00:00 [received] PHST- 2016/10/03 00:00 [accepted] PHST- 2016/11/10 06:00 [entrez] PHST- 2016/11/09 06:00 [pubmed] PHST- 2016/11/09 06:01 [medline] PHST- 2016/10/25 00:00 [pmc-release] AID - 10.3389/fmicb.2016.01640 [doi] PST - epublish SO - Front Microbiol. 2016 Oct 25;7:1640. doi: 10.3389/fmicb.2016.01640. eCollection 2016. PMID- 30057014 OWN - NLM STAT- MEDLINE DCOM- 20181220 LR - 20181220 IS - 1545-1534 (Electronic) IS - 1080-6032 (Linking) VI - 29 IP - 3 DP - 2018 Sep TI - Methoxyflurane for Procedural Analgesia at 4470 m Altitude. PG - 388-391 LID - S1080-6032(18)30054-1 [pii] LID - 10.1016/j.wem.2018.02.011 [doi] AB - Methoxyflurane is a volatile, fluorinated anesthetic agent with analgesic properties. Although no longer used as an anesthetic due to concerns regarding renal toxicity in high doses, it has enjoyed a resurgence as an inhaled analgesic in prehospital care and in the emergency department. The agent is nonflammable and leads to rapid, titratable analgesia without intravenous access. The Penthrox inhaler device is light, robust, and straightforward to administer. Consequently, it has been proposed as an ideal analgesic for the remote high altitude setting. We report its use for procedural analgesia during suprapubic aspiration for acute urinary retention at a remote rescue post at night, in cold winter conditions, at 4470 m altitude in Machermo, Nepal. We found that methoxyflurane provided rapid, effective analgesia for our patient's visceral and procedural pain. The inhaler was easy to administer, and the patient remained responsive to voice, with satisfactory oxygen saturation and respiratory rate throughout. We also briefly review the administration, dosing, efficacy, and safety of methoxyflurane and its role in remote medical care. CI - Copyright © 2018 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved. FAU - Wilkes, Matt AU - Wilkes M AD - Rescue Post Machermo, Khumbu, Nepal (Drs Wilkes and Heath). Electronic address: m.wilkes@ucl.ac.uk. FAU - Heath, Eleanor C AU - Heath EC AD - Rescue Post Machermo, Khumbu, Nepal (Drs Wilkes and Heath). FAU - Mason, Nicholas P AU - Mason NP AD - Royal Gwent Hospital, Newport, United Kingdom (Dr Mason); International Porter Protection Group, Cardiff, United Kingdom (Dr Mason). LA - eng PT - Case Reports PT - Journal Article DEP - 20180726 PL - United States TA - Wilderness Environ Med JT - Wilderness & environmental medicine JID - 9505185 RN - 0 (Anesthetics, Inhalation) RN - 30905R8O7B (Methoxyflurane) SB - IM MH - Altitude MH - Analgesia/*methods MH - Anesthetics, Inhalation/*therapeutic use MH - Humans MH - Male MH - Methoxyflurane/*therapeutic use MH - Middle Aged MH - Nepal MH - Pain Management/methods MH - Treatment Outcome MH - Urinary Retention/*drug therapy MH - Wilderness Medicine/methods OTO - NOTNLM OT - analgesia OT - anesthesia OT - conscious sedation OT - extreme environments OT - nebulizers and vaporizers OT - patient controlled OT - wilderness EDAT- 2018/07/31 06:00 MHDA- 2018/12/21 06:00 CRDT- 2018/07/31 06:00 PHST- 2017/11/23 00:00 [received] PHST- 2018/02/07 00:00 [revised] PHST- 2018/02/22 00:00 [accepted] PHST- 2018/07/31 06:00 [pubmed] PHST- 2018/12/21 06:00 [medline] PHST- 2018/07/31 06:00 [entrez] AID - S1080-6032(18)30054-1 [pii] AID - 10.1016/j.wem.2018.02.011 [doi] PST - ppublish SO - Wilderness Environ Med. 2018 Sep;29(3):388-391. doi: 10.1016/j.wem.2018.02.011. Epub 2018 Jul 26. PMID- 32683999 OWN - NLM STAT- MEDLINE DCOM- 20210128 LR - 20220416 IS - 1751-2441 (Electronic) IS - 1751-2433 (Linking) VI - 13 IP - 8 DP - 2020 Aug TI - Dose discordance of direct acting oral anticoagulants using different equations for estimating GFR: a literature review. PG - 857-863 LID - 10.1080/17512433.2020.1798759 [doi] AB - INTRODUCTION: Direct oral anticoagulants (DOACs) are widely prescribed nowadays. Available DOACs are renally eliminated to some extent and need dose adjustment in patients with kidney dysfunction. Cockcroft-Gault (CG) formula has been used to estimate creatinine clearance in DOACs trials. Nowadays, Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) are preferred equations for estimating glomerular filtration rate (GFR). We reviewed studies that simulated DOACs dosing in patients with atrial fibrillation by MDRD, CKD-EPI, and CG. AREAS COVERED: DOACs dose discordance varies from 28.8% underdosing to 59.2% overdosing when MDRD or CKD-EPI equations are substituted for CG. MDRD and CKD-EPI overestimate the GFR in lower thresholds of kidney function especially in elderly and females and result in overestimation of DOACs dosing or misclassifying the patients to be eligible for receiving DOACs when they are contraindicated. Compared with CG, MDRD and CKD-EPI underestimate the level of kidney function in higher GFR extremes and in these patients suggest DOACs when they are not recommended or suggest lower doses. EXPERT OPINION: Until running large clinical studies on efficacy/safety of DOACs dosing using MDRD or CKD-EPI equations, use of CG method for DOACs dosing is recommended in real practice. FAU - Nabiee, Morteza AU - Nabiee M AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran. FAU - Dashti-Khavidaki, Simin AU - Dashti-Khavidaki S AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran. FAU - Khajeh, Behrouz AU - Khajeh B AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran, Iran. LA - eng PT - Comparative Study PT - Journal Article PT - Review DEP - 20200727 PL - England TA - Expert Rev Clin Pharmacol JT - Expert review of clinical pharmacology JID - 101278296 RN - 0 (Factor Xa Inhibitors) SB - IM MH - Administration, Oral MH - Aged MH - Atrial Fibrillation/drug therapy MH - Dose-Response Relationship, Drug MH - Drug Dosage Calculations MH - Factor Xa Inhibitors/*administration & dosage/pharmacokinetics MH - Female MH - Glomerular Filtration Rate/*physiology MH - Humans MH - Kidney Diseases/*physiopathology MH - Kidney Function Tests MH - Male OTO - NOTNLM OT - CKD-EPI OT - Cockcroft-Gault OT - DOACs OT - MDRD OT - direct oral anticoagulants OT - dose adjustment OT - glomerular filtration rate EDAT- 2020/07/21 06:00 MHDA- 2021/01/29 06:00 CRDT- 2020/07/21 06:00 PHST- 2020/07/21 06:00 [pubmed] PHST- 2021/01/29 06:00 [medline] PHST- 2020/07/21 06:00 [entrez] AID - 10.1080/17512433.2020.1798759 [doi] PST - ppublish SO - Expert Rev Clin Pharmacol. 2020 Aug;13(8):857-863. doi: 10.1080/17512433.2020.1798759. Epub 2020 Jul 27. PMID- 25735611 OWN - NLM STAT- MEDLINE DCOM- 20180507 LR - 20220316 IS - 1752-8526 (Electronic) VI - 2015 DP - 2015 Mar 4 TI - Bulimia nervosa: online interventions. LID - 1009 [pii] AB - INTRODUCTION: Up to 1% of people in the community may have bulimia nervosa, characterised by an intense preoccupation with body weight, binge-eating episodes, and use of extreme measures to counteract the feared effects of overeating. People with bulimia nervosa are of normal weight or are overweight, making the condition distinct from anorexia nervosa. After 10 years, about half of people with bulimia nervosa will have recovered fully, one third will have made a partial recovery, and 10% to 20% will still have symptoms. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of online interventions for people with bulimia nervosa? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found eight studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: applications (apps) or online programmes used as an adjunct to face-to-face therapy, delivery of self-help online, and delivery of therapy online. FAU - Hay, Phillipa J AU - Hay PJ AD - School of Medicine, Campbelltown Campus, Western Sydney University, Sydney, Australia. FAU - Claudino, Angélica Medeiros AU - Claudino AM LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20150304 PL - England TA - BMJ Clin Evid JT - BMJ clinical evidence JID - 101294314 SB - IM MH - Bulimia Nervosa/*therapy MH - Humans MH - *Internet MH - Psychology, Clinical/*methods MH - Psychotherapy/*instrumentation MH - Treatment Outcome PMC - PMC4356174 EDAT- 2015/03/05 06:00 MHDA- 2018/05/08 06:00 PMCR- 2017/03/04 CRDT- 2015/03/05 06:00 PHST- 2015/03/05 06:00 [entrez] PHST- 2015/03/05 06:00 [pubmed] PHST- 2018/05/08 06:00 [medline] PHST- 2017/03/04 00:00 [pmc-release] AID - 1009 [pii] PST - epublish SO - BMJ Clin Evid. 2015 Mar 4;2015:1009. PMID- 31148099 OWN - NLM STAT- MEDLINE DCOM- 20200612 LR - 20200612 IS - 1720-8319 (Electronic) IS - 1594-0667 (Linking) VI - 32 IP - 3 DP - 2020 Mar TI - Association of nimodipine and choline alphoscerate in the treatment of cognitive impairment in patients with cerebral small vessel disease: study protocol for a randomized placebo-controlled trial-the CONIVaD trial. PG - 449-457 LID - 10.1007/s40520-019-01229-z [doi] AB - BACKGROUND: Vascular cognitive impairment (VCI) is an extremely disabling condition that includes post-stroke dementia and VCI caused by cerebral small vessel disease (SVD). Currently, there is no approved treatment for this condition. Drugs active on the cholinergic pathway have been tested in VCI patients showing positive but limited efficacy. The calcium-antagonist nimodipine also showed some moderate positive effects in VCI patients. AIMS: CONIVaD (choline alphoscerate and nimodipine in vascular dementia) is a pilot, single-center, double-blinded, randomized trial aimed to assess whether the association of choline alphoscerate and nimodipine is more effective than nimodipine alone in reducing cognitive decline in patients with SVD and mild-to-moderate cognitive impairment. METHODS: All patients are evaluated at baseline and after 12 months with: (1) clinical, daily functions, quality of life, and mood assessment and (2) extensive neuropsychological evaluation. After the baseline evaluation, patients are randomly assigned to one of the two arms of treatment: (1) nimodipine 90 mg/die t.i.d plus placebo b.i.d and (2) nimodipine 90 mg t.i.d plus choline alphoscerate 1200 mg/die b.i.d. for a total of 12 months. The primary endpoint is cognitive decline, expressed as the loss of at least two points on the Montreal Cognitive Assessment at 12 months. Secondary endpoints include safety and tolerability, functional, quality of life, and neuropsychological measures. DISCUSSION: CONIVaD study is the first randomized controlled trial to examine the cognitive efficacy of combined choline alphoscerate-nimodipine treatment in VCI patients. Results of this pilot study will serve as a methodological basis for other clinical controlled, multicentric, double-blinded, and randomized trials. TRIAL REGISTRATION: Clinical Trial NCT03228498. Registered 25 July 2017. FAU - Salvadori, Emilia AU - Salvadori E AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Poggesi, Anna AU - Poggesi A AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Donnini, Ida AU - Donnini I AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Rinnoci, Valentina AU - Rinnoci V AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Chiti, Guido AU - Chiti G AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Squitieri, Martina AU - Squitieri M AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Tudisco, Laura AU - Tudisco L AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Fierini, Fabio AU - Fierini F AD - Psychiatry Unit, Department of Health Sciences, University of Florence, Florence, Italy. FAU - Melone, Anna AU - Melone A AD - NEUROFARBA Department, University of Florence, Florence, Italy. FAU - Pescini, Francesca AU - Pescini F AD - Stroke Unit, Emergency Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy. FAU - Pantoni, Leonardo AU - Pantoni L AUID- ORCID: 0000-0001-7357-8530 AD - Department of Biomedical and Clinical Sciences, 'L. Sacco' Hospital, University of Milan, Via Giovanni Battista Grassi 74, 20157, Milan, Italy. leonardo.pantoni@unimi.it. LA - eng SI - ClinicalTrials.gov/NCT03228498 PT - Clinical Trial Protocol PT - Journal Article DEP - 20190530 PL - Germany TA - Aging Clin Exp Res JT - Aging clinical and experimental research JID - 101132995 RN - 0 (Calcium Channel Blockers) RN - 57WA9QZ5WH (Nimodipine) RN - 60M22SGW66 (Glycerylphosphorylcholine) SB - IM MH - Aged MH - Calcium Channel Blockers/*administration & dosage MH - Cerebral Small Vessel Diseases/complications/*drug therapy MH - Cognitive Dysfunction/etiology/*prevention & control MH - Dementia, Vascular/complications MH - Drug Therapy, Combination MH - Female MH - Glycerylphosphorylcholine/*administration & dosage MH - Humans MH - Male MH - Middle Aged MH - Nimodipine/*administration & dosage MH - Randomized Controlled Trials as Topic OTO - NOTNLM OT - Choline alphoscerate OT - MoCA OT - Nimodipine OT - Small vessel disease OT - Therapy OT - Vascular cognitive impairment EDAT- 2019/05/31 06:00 MHDA- 2020/06/13 06:00 CRDT- 2019/06/01 06:00 PHST- 2019/03/14 00:00 [received] PHST- 2019/05/18 00:00 [accepted] PHST- 2019/05/31 06:00 [pubmed] PHST- 2020/06/13 06:00 [medline] PHST- 2019/06/01 06:00 [entrez] AID - 10.1007/s40520-019-01229-z [pii] AID - 10.1007/s40520-019-01229-z [doi] PST - ppublish SO - Aging Clin Exp Res. 2020 Mar;32(3):449-457. doi: 10.1007/s40520-019-01229-z. Epub 2019 May 30. PMID- 30992220 OWN - NLM STAT- MEDLINE DCOM- 20200413 LR - 20200413 IS - 1097-6833 (Electronic) IS - 0022-3476 (Linking) VI - 210 DP - 2019 Jul TI - Safety of Intratracheal Administration of Human Umbilical Cord Blood Derived Mesenchymal Stromal Cells in Extremely Low Birth Weight Preterm Infants. PG - 209-213.e2 LID - S0022-3476(19)30261-6 [pii] LID - 10.1016/j.jpeds.2019.02.029 [doi] AB - In a phase 1 dose-escalation trial at 2 dosing levels, we assessed the safety of intratracheal administration of a single-dose of human umbilical cord blood-derived mesenchymal stromal cells in 12 extremely low birth weight infants <28 weeks of gestation and <1000 g at birth at 5-14 days of life. The treatment was well tolerated and appears to be safe and feasible, and warrants a larger randomized-controlled blinded study. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02381366. CI - Copyright © 2019. Published by Elsevier Inc. FAU - Powell, Steven B AU - Powell SB AD - Department of Pediatrics, Rush University Children's Hospital, Chicago, IL. Electronic address: steven_powell@rush.edu. FAU - Silvestri, Jean M AU - Silvestri JM AD - Department of Pediatrics, Rush University Children's Hospital, Chicago, IL. LA - eng SI - ClinicalTrials.gov/NCT02381366 PT - Clinical Trial, Phase I PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190413 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 SB - IM CIN - J Pediatr. 2019 Sep;212:246. doi: 10.1016/j.jpeds.2019.05.063. PMID: 31255387 CIN - J Pediatr. 2019 Sep;212:246-247. doi: 10.1016/j.jpeds.2019.05.064. PMID: 31300311 MH - Bronchopulmonary Dysplasia/*prevention & control MH - Cord Blood Stem Cell Transplantation/*methods MH - Female MH - Humans MH - *Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - *Infant, Premature MH - Intensive Care Units, Neonatal MH - Intubation, Intratracheal MH - Male MH - Mesenchymal Stem Cell Transplantation/*methods MH - Severity of Illness Index OTO - NOTNLM OT - BPD OT - MSCs OT - NICU OT - chronic lung disease OT - neonatal OT - neonatal intensive care unit OT - newborn OT - prematurity OT - stem cells EDAT- 2019/04/18 06:00 MHDA- 2020/04/14 06:00 CRDT- 2019/04/18 06:00 PHST- 2018/09/27 00:00 [received] PHST- 2019/01/24 00:00 [revised] PHST- 2019/02/15 00:00 [accepted] PHST- 2019/04/18 06:00 [pubmed] PHST- 2020/04/14 06:00 [medline] PHST- 2019/04/18 06:00 [entrez] AID - S0022-3476(19)30261-6 [pii] AID - 10.1016/j.jpeds.2019.02.029 [doi] PST - ppublish SO - J Pediatr. 2019 Jul;210:209-213.e2. doi: 10.1016/j.jpeds.2019.02.029. Epub 2019 Apr 13. PMID- 38882191 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240617 IS - 2352-3409 (Electronic) IS - 2352-3409 (Linking) VI - 54 DP - 2024 Jun TI - Dataset on extreme thunderstorm ground enhancements registered on Aragats in 2023. PG - 110554 LID - 10.1016/j.dib.2024.110554 [doi] LID - 110554 AB - To advance high-energy atmospheric physics, studying atmospheric electric fields (AEF) and cosmic ray fluxes as an interconnected system is crucial. At Mt. Argats, simultaneous measurements of particle fluxes, electric fields, weather conditions, and lightning locations have significantly enhanced the validation of models that describe the charge structures of thunderclouds and the mechanics of internal electron accelerators. In 2023, observations of the five largest thunderstorm ground enhancements (TGEs) revealed electric fields exceeding 2.0 kV/cm at elevations just tens of meters above ground-potentially hazardous to rockets and aircraft during launch and charging operations. Utilizing simple yet effective monitoring equipment developed at Aragats, we can mitigate the risks posed by these high-intensity fields. The Mendeley dataset, comprising various measured parameters during thunderstorm activities, enables researchers to perform advanced correlation analysis and uncover complex relationships between these atmospheric phenomena. This study underscores the critical importance of integrated atmospheric studies for ensuring the safety of high-altitude operations and advancing atmospheric science. CI - © 2024 The Author(s). FAU - Chilingarian, A AU - Chilingarian A AD - Alikhanyan National Laboratory (Yerevan Physics Institute), Yerevan 0036, Armenia. FAU - Karapetyan, T AU - Karapetyan T AD - Alikhanyan National Laboratory (Yerevan Physics Institute), Yerevan 0036, Armenia. FAU - Sargsyan, B AU - Sargsyan B AD - Alikhanyan National Laboratory (Yerevan Physics Institute), Yerevan 0036, Armenia. FAU - Aslanyan, D AU - Aslanyan D AD - Alikhanyan National Laboratory (Yerevan Physics Institute), Yerevan 0036, Armenia. FAU - Chilingaryan, S AU - Chilingaryan S AD - Alikhanyan National Laboratory (Yerevan Physics Institute), Yerevan 0036, Armenia. AD - Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz, 176344 Eggenstein-Leopoldshafen, Germany. LA - eng PT - Journal Article DEP - 20240525 PL - Netherlands TA - Data Brief JT - Data in brief JID - 101654995 PMC - PMC11180300 OTO - NOTNLM OT - Atmospheric electric field OT - Correlation analysis OT - Data mining OT - Electron accelerator OT - Electron and gamma-ray energy spectra OT - Natural radiation EDAT- 2024/06/17 06:43 MHDA- 2024/06/17 06:44 PMCR- 2024/05/25 CRDT- 2024/06/17 05:53 PHST- 2024/02/13 00:00 [received] PHST- 2024/05/19 00:00 [revised] PHST- 2024/05/20 00:00 [accepted] PHST- 2024/06/17 06:44 [medline] PHST- 2024/06/17 06:43 [pubmed] PHST- 2024/06/17 05:53 [entrez] PHST- 2024/05/25 00:00 [pmc-release] AID - S2352-3409(24)00521-3 [pii] AID - 110554 [pii] AID - 10.1016/j.dib.2024.110554 [doi] PST - epublish SO - Data Brief. 2024 May 25;54:110554. doi: 10.1016/j.dib.2024.110554. eCollection 2024 Jun. PMID- 38292425 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241023 IS - 2589-0042 (Electronic) IS - 2589-0042 (Linking) VI - 27 IP - 2 DP - 2024 Feb 16 TI - Synthesizing nuclear power plant fouling with fractal characteristics enables an in-depth study of concerned nuclear safety issues. PG - 108789 LID - 10.1016/j.isci.2024.108789 [doi] LID - 108789 AB - Fouling deposit on nuclear fuel cladding causes wick boiling and boron hideout, resulting in localized corrosion and power shift with great potential security and economic risks. Herein, a cost-effective time-saving adjustable reproduction method combining sol-gel with ceramic sintering is presented to enable wide coverage of fouling's morphologies and microstructures. Based on fractal analysis, structurally self-similar fouling deposits from different reactors conform to proposed porosity-fractal dimension law under 3% relative error. Wick boiling and boron hideout numerical simulation based on fractal dimension is implemented to treat different morphologies and structures in a unified way. Cladding surface underneath fouling deposit has a maximum 9.243 K temperature increasement due to thermal resistance, and H(3)BO(3) is concentrated 11.274 times by mean of wick boiling, causing Li(2)B(4)O(7) precipitation under extreme conditions with low porosity and high heat flux. The insights in this study provide a precise approach for quantitative evaluation of localized corrosion and power shift. CI - © 2024 The Author(s). FAU - Liu, Yan AU - Liu Y AD - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Liu, Xiaojing AU - Liu X AD - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - He, Hui AU - He H AD - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Zhang, Tengfei AU - Zhang T AD - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. FAU - Chai, Xiang AU - Chai X AD - School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. LA - eng PT - Journal Article DEP - 20240104 PL - United States TA - iScience JT - iScience JID - 101724038 PMC - PMC10825680 OTO - NOTNLM OT - Engineering OT - Materials science OT - Nuclear chemistry OT - Nuclear engineering COIS- The authors declare no competing interests. EDAT- 2024/01/31 06:42 MHDA- 2024/01/31 06:43 PMCR- 2024/01/04 CRDT- 2024/01/31 04:11 PHST- 2023/08/15 00:00 [received] PHST- 2023/11/08 00:00 [revised] PHST- 2024/01/02 00:00 [accepted] PHST- 2024/01/31 06:43 [medline] PHST- 2024/01/31 06:42 [pubmed] PHST- 2024/01/31 04:11 [entrez] PHST- 2024/01/04 00:00 [pmc-release] AID - S2589-0042(24)00010-5 [pii] AID - 108789 [pii] AID - 10.1016/j.isci.2024.108789 [doi] PST - epublish SO - iScience. 2024 Jan 4;27(2):108789. doi: 10.1016/j.isci.2024.108789. eCollection 2024 Feb 16. PMID- 39592426 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250111 IS - 1521-3765 (Electronic) IS - 0947-6539 (Linking) VI - 31 IP - 2 DP - 2025 Jan 9 TI - Design Concepts of High-Entropy Materials for Zinc Ion Batteries. PG - e202402859 LID - 10.1002/chem.202402859 [doi] AB - Zinc-ion batteries have emerged as strong candidates for replacing Li/Na-ion batteries owing to their high safety and environmental friendliness. However, the large electrostatic repulsion between the cathode and Zn(2+), the irreversible growth of zinc dendrites at the anode, and the hydrogen precipitation side reaction in the aqueous electrolyte have hindered the practical application of zinc ion batteries. Fortunately, the emergence of the revolutionary concept of high entropy has provided new opportunities for the development of battery materials. High-entropy materials, with their unique atomic structures and uniform distribution of multiple elements, offer flexible options for material compositions and electronic structures, thus attracting significant attention in battery systems. In this concept article, we summarize the definitions and intrinsic structural characteristics of high-entropy materials and provide a detailed overview of the latest design concepts from the perspectives of cathodes, anodes, and electrolytes. Finally, we outline the challenges faced by high-entropy materials and potential solutions to guide researchers in developing efficient and stable zinc-ion batteries. CI - © 2024 Wiley-VCH GmbH. FAU - Sun, Kaisheng AU - Sun K AD - College of Chemistry, Jilin University, Changchun, 130012, China. AD - Synergetic Extreme Condition High-Pressure Science Center, State Key Laboratory of Superhard Materials, College of Physics, Jilin University, 130012, Changchun, P. R. China. FAU - Li, Jiaru AU - Li J AD - College of Chemistry, Jilin University, Changchun, 130012, China. FAU - Li, Liang AU - Li L AD - Synergetic Extreme Condition High-Pressure Science Center, State Key Laboratory of Superhard Materials, College of Physics, Jilin University, 130012, Changchun, P. R. China. FAU - Chao, Danming AU - Chao D AUID- ORCID: 0000-0003-1324-6731 AD - College of Chemistry, Jilin University, Changchun, 130012, China. LA - eng GR - 22275066/National Natural Science Foundation of China/ GR - 20240601044RC/Jilin Provincial Science and Technology Department/ GR - the Synergetic Extreme Condition User Facility(SECUF)/ PT - Journal Article DEP - 20241205 PL - Germany TA - Chemistry JT - Chemistry (Weinheim an der Bergstrasse, Germany) JID - 9513783 SB - IM OTO - NOTNLM OT - design concepts OT - high-entropy materials OT - zinc-ion batteries EDAT- 2024/11/27 00:21 MHDA- 2024/11/27 00:22 CRDT- 2024/11/26 22:43 PHST- 2024/07/30 00:00 [received] PHST- 2024/11/27 00:22 [medline] PHST- 2024/11/27 00:21 [pubmed] PHST- 2024/11/26 22:43 [entrez] AID - 10.1002/chem.202402859 [doi] PST - ppublish SO - Chemistry. 2025 Jan 9;31(2):e202402859. doi: 10.1002/chem.202402859. Epub 2024 Dec 5. PMID- 38690340 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240502 IS - 2212-6287 (Print) IS - 2212-6287 (Electronic) IS - 2212-6287 (Linking) VI - 13 IP - 4 DP - 2024 Apr TI - Arthroscopic Patella Realignment for Children And Adolescents: A Single Incision Technique. PG - 102900 LID - 10.1016/j.eats.2023.102900 [doi] LID - 102900 AB - Management of patellofemoral conditions in children and adolescents can be extremely challenging. Apart from the patellofemoral instability patients, there are several other disorders that can cause significant morbidity, patellofemoral maltracking, patellar tilt, and Hoffa's fat pad impingement syndrome are common problems that may not respond to nonoperative management. Understanding the exact pathology and apply the appropriate management is critical for successful outcome. Identification of novel surgical interventions that can provide symptom relief in a safe manner is important. This technical note describes a surgical technique for patella realignment in young patients that combines safety, simplicity, and reproducibility. CI - © 2023 The Authors. FAU - Paschos, Nikolaos K AU - Paschos NK AD - Department of Orthopaedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, U.S.A. LA - eng PT - Journal Article DEP - 20240109 PL - Netherlands TA - Arthrosc Tech JT - Arthroscopy techniques JID - 101597442 PMC - PMC11056612 COIS- The author reports the following potential conflicts of interest or sources of funding: N.K.P reports personal fees from AANA, during the conduct of the study. Full ICMJE author disclosure forms are available for this article online, as supplementary material. EDAT- 2024/05/01 06:56 MHDA- 2024/05/01 06:57 PMCR- 2024/01/09 CRDT- 2024/05/01 03:47 PHST- 2023/09/22 00:00 [received] PHST- 2023/12/01 00:00 [accepted] PHST- 2024/05/01 06:57 [medline] PHST- 2024/05/01 06:56 [pubmed] PHST- 2024/05/01 03:47 [entrez] PHST- 2024/01/09 00:00 [pmc-release] AID - S2212-6287(23)00361-4 [pii] AID - 102900 [pii] AID - 10.1016/j.eats.2023.102900 [doi] PST - epublish SO - Arthrosc Tech. 2024 Jan 9;13(4):102900. doi: 10.1016/j.eats.2023.102900. eCollection 2024 Apr. PMID- 34594974 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240403 IS - 2096-7071 (Electronic) IS - 2096-7071 (Linking) VI - 3 IP - 34 DP - 2021 Aug 20 TI - Field Simulation of Aerosol Transmission of SARS-CoV-2 in a Special Building Layout - Guangdong Province, China, 2021. PG - 711-715 LID - 10.46234/ccdcw2021.176 [doi] AB - WHAT IS ALREADY KNOWN ON THIS TOPIC? Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and usually occurred in confined spaces. WHAT IS ADDED BY THIS REPORT? Aerosol transmission was found to exist between handshake buildings, i.e., buildings with extremely close proximity that formed relatively enclosed spaces. Transmission was mainly affected by the airflow layout caused by switching air conditioners on and off as well as opening and closing doors and windows. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? Centralized isolation and home isolation in handshake buildings creates a risk of SARS-CoV-2 aerosol transmission under certain conditions. Attention should be paid to the influence of air distribution layout on aerosol diffusion in isolation wards, and disinfection of isolation venues should be strengthened. CI - Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2021. FAU - Zhang, Zhuona AU - Zhang Z AD - National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing, China. FAU - Li, Xia AU - Li X AD - National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing, China. FAU - Wang, Qin AU - Wang Q AD - National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing, China. FAU - Xu, Jin AU - Xu J AD - China National Center for Food Safety Risk Assessment, Beijing, China. FAU - Jiang, Qinqin AU - Jiang Q AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Jiang, Sili AU - Jiang S AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Lyu, Jiayun AU - Lyu J AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Liu, Shiqiang AU - Liu S AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Ye, Ling AU - Ye L AD - Guangdong field epidemiology training program, Guangzhou, Guangdong, China; Heyuan municipal center for disease control and prevention, Heyuan, Guangdong, China. FAU - Yuan, Jun AU - Yuan J AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Feng, Wenru AU - Feng W AD - Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, China. FAU - Xu, Dongqun AU - Xu D AD - National Institute of Environmental Health, China Center for Disease Control and Prevention, Beijing, China. LA - eng PT - Journal Article PL - China TA - China CDC Wkly JT - China CDC weekly JID - 101767554 PMC - PMC8392788 OTO - NOTNLM OT - aerosol transmission OT - airflow layout OT - simulations COIS- Conflicts of interestNo conflicts of interest. EDAT- 2021/10/02 06:00 MHDA- 2021/10/02 06:01 PMCR- 2021/08/20 CRDT- 2021/10/01 07:33 PHST- 2021/07/31 00:00 [received] PHST- 2021/08/11 00:00 [accepted] PHST- 2021/10/01 07:33 [entrez] PHST- 2021/10/02 06:00 [pubmed] PHST- 2021/10/02 06:01 [medline] PHST- 2021/08/20 00:00 [pmc-release] AID - ccdcw-3-34-711 [pii] AID - 10.46234/ccdcw2021.176 [doi] PST - ppublish SO - China CDC Wkly. 2021 Aug 20;3(34):711-715. doi: 10.46234/ccdcw2021.176. PMID- 31183359 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2314-5765 (Print) IS - 2314-5765 (Electronic) IS - 2314-5765 (Linking) VI - 2019 DP - 2019 TI - Postharvest Handling Practices and Perception of Potato Safety among Potato Traders in Nairobi, Kenya. PG - 2342619 LID - 10.1155/2019/2342619 [doi] LID - 2342619 AB - Postharvest handling of the potato is an important factor not only in preventing postharvest losses but also in maintaining its safety and nutritional quality. Exposure of the potato to unfavorable conditions such as light, extreme temperatures, and bruising can result in accumulation of glycoalkaloids, which are toxic substances. This study was a cross-sectional survey which aimed to investigate the postharvest handling practices of potatoes and perception of potato safety among open air market traders in Nairobi County, Kenya. Information was collected from 100 potato traders using a semistructured questionnaire that assessed postharvest handling practices such as potato transportation, exposure to sunlight, and storage. Results indicated that most of the potatoes (88%) took one day to be transported to the market, with the storage period at the market ranging from 2 to 3 days for most traders (42%). Forty-seven percent (47%) of the vehicles and hand-pulled carts used to transport potatoes had open backs, while 53% had closed backs. Over half (69%) of the potatoes in the markets were directly exposed to sunlight, with 75% of the traders leaving their potatoes in the open covered with a polythene bag after the day's activities. Greening, sprouting, or bruised potatoes were mostly sold as seed, sold to restaurants and French fries vendors, or sold to consumers at a lower price. More than half of the traders did not think that consumption of greened potatoes is harmful to health. The results clearly show that there is poor handling of the potatoes by the traders which increases the risk of consumer exposure to glycoalkaloids. There is, therefore, a need to create awareness among traders on appropriate postharvest handling of potatoes to protect consumer health and reduce economic losses as well. FAU - Musita, Consolata Nolega AU - Musita CN AUID- ORCID: 0000-0001-7219-1924 AD - Department of Food Science, Nutrition and Technology, University of Nairobi, Kenya. FAU - Okoth, Michael Wandayi AU - Okoth MW AD - Department of Food Science, Nutrition and Technology, University of Nairobi, Kenya. FAU - Abong', George Ooko AU - Abong' GO AUID- ORCID: 0000-0003-2524-7862 AD - Department of Food Science, Nutrition and Technology, University of Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20190428 PL - United States TA - Int J Food Sci JT - International journal of food science JID - 101627297 PMC - PMC6512071 EDAT- 2019/06/12 06:00 MHDA- 2019/06/12 06:01 PMCR- 2019/04/28 CRDT- 2019/06/12 06:00 PHST- 2018/10/03 00:00 [received] PHST- 2019/03/24 00:00 [revised] PHST- 2019/04/14 00:00 [accepted] PHST- 2019/06/12 06:00 [entrez] PHST- 2019/06/12 06:00 [pubmed] PHST- 2019/06/12 06:01 [medline] PHST- 2019/04/28 00:00 [pmc-release] AID - 10.1155/2019/2342619 [doi] PST - epublish SO - Int J Food Sci. 2019 Apr 28;2019:2342619. doi: 10.1155/2019/2342619. eCollection 2019. PMID- 36831709 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230228 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 13 IP - 2 DP - 2023 Jan 18 TI - The Safety and Feasibility of Lower Body Positive Pressure Treadmill Training in Individuals with Chronic Stroke: An Exploratory Study. LID - 10.3390/brainsci13020166 [doi] LID - 166 AB - BACKGROUND: Lower body positive pressure (LBPP) may provide a novel intervention for gait training in neurological conditions. Nonetheless, studies investigating the safety and feasibility of LBPP in patients with stroke are insufficient. OBJECTIVES: The purpose of this study was to evaluate the safety and feasibility of LBPP as a rehabilitation intervention for individuals with chronic stroke. METHODS: Individuals with chronic stroke were recruited from the community to participate in LBPP gait training three times a week for six weeks. The LBPP's safety and feasibility were documented throughout the study and at the end of six weeks. Safety and feasibility referred to the incidence of adverse events, complications, the participant and therapist satisfaction questionnaire, and the device limitation including but not limited to technical issues and physical constraints. In addition, blood pressure, pulse rate, and oxygen saturation were taken pre- and post-session. Dependent t-tests were used to analyze the difference between assessments. A Wilcoxon test was used to assess the ordinal data (Trial registration number NCT04767334). RESULTS: Nine individuals (one female, eight males) aged 57 ± 15.4 years were enrolled. All participants completed the intervention without adverse events. All participants reported positive scores from 4 (very satisfying) to 5 (extremely satisfying) in the safety and feasibility questionnaire. No significant differences were observed in blood pressure and oxygen saturation during the intervention sessions. However, significant increases were observed in heart rate from 82.6 ± 9.1 beats/min (pre-session) to 88.1 ± 6.8 beats/min (post-session) (p = 0.027). CONCLUSIONS: LBPP is a safe and feasible rehabilitation tool to use with individuals with chronic stroke. FAU - Almutairi, Sattam M AU - Almutairi SM AUID- ORCID: 0000-0002-2282-7127 AD - Department of Physical Therapy, College of Medical Rehabilitation Science, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Alfouzan, Moodhi M AU - Alfouzan MM AUID- ORCID: 0000-0003-1227-6058 AD - Department of Physical Therapy, College of Medical Rehabilitation Science, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Almutairi, Taghreed S AU - Almutairi TS AD - Department of Physical Therapy, College of Medical Rehabilitation Science, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Alkaabi, Hatem A AU - Alkaabi HA AD - Rehabilitation Department, Qassim University Medical City, Buraydah 52571, Saudi Arabia. FAU - AlMulaifi, Misoon T AU - AlMulaifi MT AD - Rehabilitation Department, Qassim University Medical City, Buraydah 52571, Saudi Arabia. FAU - Almutairi, Marzouq K AU - Almutairi MK AD - Department of Physical Therapy, College of Medical Rehabilitation Science, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Alhuthaifi, Faisal K AU - Alhuthaifi FK AD - Department of Physical Therapy, College of Medical Rehabilitation Science, Qassim University, Buraydah 52571, Saudi Arabia. FAU - Swank, Chad AU - Swank C AD - Baylor Scott & White Research Institute, Dallas, TX 75246, USA. LA - eng SI - ClinicalTrials.gov/NCT04767334 PT - Journal Article DEP - 20230118 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC9954131 OTO - NOTNLM OT - assistive technology OT - gait disorder OT - locomotion OT - rehabilitation OT - stroke COIS- The authors declare no conflict of interest. EDAT- 2023/02/26 06:00 MHDA- 2023/02/26 06:01 PMCR- 2023/01/18 CRDT- 2023/02/25 01:43 PHST- 2023/01/04 00:00 [received] PHST- 2023/01/13 00:00 [revised] PHST- 2023/01/16 00:00 [accepted] PHST- 2023/02/25 01:43 [entrez] PHST- 2023/02/26 06:00 [pubmed] PHST- 2023/02/26 06:01 [medline] PHST- 2023/01/18 00:00 [pmc-release] AID - brainsci13020166 [pii] AID - brainsci-13-00166 [pii] AID - 10.3390/brainsci13020166 [doi] PST - epublish SO - Brain Sci. 2023 Jan 18;13(2):166. doi: 10.3390/brainsci13020166. PMID- 38405027 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 0194-4363 (Print) IS - 0194-4363 (Linking) VI - 90 IP - 1 DP - 2024 TI - Lessons Learned from a Citywide Abandoned Housing Experiment. PG - 159-172 LID - 10.1080/01944363.2022.2128855 [doi] AB - PROBLEM RESEARCH STRATEGY AND FINDINGS: The negative impact of vacant and abandoned housing in city neighborhoods is extreme, affecting health and quality of life, promoting violence, and leading to further abandonment. One approach to addressing abandoned housing is to intervene with low-cost interventions that provide a visual sense of ownership. We tested whether a low-cost remediation of abandoned and vacant houses or a trash cleanup intervention would make a noticeable difference in the levels of nearby disrepair, disorder, and public safety. The abandoned housing remediation and trash cleanup interventions were a test of compliance with municipal ordinances. We used an experimental design to test the causal effects of the ordinances, and because the scale of abandonment was too large to provide treatment to all abandoned houses in the city. We used systematic social observation methods to rate changes in disrepair, disorder, and litter at housing sites and on the city blocks they were located, and police reported data on gun violence and illegal substance uses. Our experimental design allowed us to see if observed disrepair, disorder, and public safety improved after working windows and doors were installed on abandoned houses compared with a trash cleanup around properties or a no-intervention control condition. Our results showed significant changes in observed disrepair, disorder, and gun violence and illustrate the benefits of experimental evaluations of place-based changes to the built environment. TAKEAWAY FOR PRACTICE: Improving compliance with ordinances to remediate abandoned housing can make a noticeable difference in disrepair in neighborhoods and contribute improved public safety. We illustrate how planners can use field experiments in partnership with city agencies, nonprofit community groups, and local universities to discover novel approaches to advance place-based changes to the built environment that can help economically disadvantaged communities abate problems of physical disorder. FAU - MacDonald, John AU - MacDonald J AD - Departments of Criminology and Sociology at the University of Pennsylvania. FAU - Jacobowitz, Ahuva AU - Jacobowitz A AD - Mailman School of Public Health at Columbia University. FAU - Gravel, Jason AU - Gravel J AD - Department of Criminal Justice at Temple University. FAU - Smith, Mitchell AU - Smith M AD - School of Criminology and Criminal Justice at Arizona State University. FAU - Stokes, Robert AU - Stokes R AD - Department of Public Administration at California State University, San Bernardino. FAU - Tam, Vicky AU - Tam V AD - Department of Biomedical and Health Informatics at the Children's Hospital of Philadelphia. FAU - South, Eugenia AU - South E AD - Perelman School of Medicine at the University of Pennsylvania. FAU - Branas, Charles AU - Branas C AD - Mailman School of Public Health at Columbia University. LA - eng GR - R01 AA024941/AA/NIAAA NIH HHS/United States PT - Journal Article DEP - 20230203 PL - United States TA - J Am Plann Assoc JT - Journal of the American Planning Association. American Planning Association JID - 9878432 PMC - PMC10883667 MID - NIHMS1848355 OTO - NOTNLM OT - abandoned housing OT - concentrated disadvantage OT - disorder OT - experiment OT - reinvestment OT - zoning ordinances EDAT- 2024/02/26 06:42 MHDA- 2024/02/26 06:43 PMCR- 2025/01/01 CRDT- 2024/02/26 04:36 PHST- 2024/02/26 06:43 [medline] PHST- 2024/02/26 06:42 [pubmed] PHST- 2024/02/26 04:36 [entrez] PHST- 2025/01/01 00:00 [pmc-release] AID - 10.1080/01944363.2022.2128855 [doi] PST - ppublish SO - J Am Plann Assoc. 2024;90(1):159-172. doi: 10.1080/01944363.2022.2128855. Epub 2023 Feb 3. PMID- 31004038 OWN - NLM STAT- MEDLINE DCOM- 20200605 LR - 20200605 IS - 1948-2124 (Electronic) IS - 1079-7440 (Linking) VI - 73 IP - 5 DP - 2019 Sep-Oct TI - Single-Use System Integrity I: Using a Microbial Ingress Test Method to Determine the Maximum Allowable Leakage Limit (MALL). PG - 459-469 LID - 10.5731/pdajpst.2018.009688 [doi] AB - An aerosol microbial ingress test was specifically designed and used to create a predictive model in order to determine the maximum allowable leakage limit (MALL) of single-use systems (SUSs). The MALL is defined as the greatest leak size that does not pose any risk to the product. The procedure involved taking test samples of film material from single-use bags. As test samples, an ethylene vinyl acetate multilayer film (300 μm thick) and a polyethylene multilayer film (400 μm thick) were cut into 50 mm patches. Artificial defects of 1-100 µm were laser-drilled in the middle of each film patch. The patch was assembled on a holder and properly sealed. The test units were filled aseptically with culture media and placed inside an aerosol chamber. Various pressures were applied to the test unit to simulate the constraints that single-use systems may be subject to under real-world conditions. After an aerosolization cycle with spores of Bacillus atrophaeus, a minimum concentration of 10(6) CFU/cm(2) was reached on the film surface. The test units were incubated for 14 days at 30°C-35°C and visually inspected for bacterial ingress. Thirty samples per defect size were tested. Logistic regression was used to indicate the MALL for a single-use system according to the required risk level. With this method, the probability of the occurrence or absence of ingress for a specific defect size was reported according to the experimental data. In addition to physical parameters, such as the pressure applied and the film material, the effect of the probabilistic nature of the microorganisms in determining the MALL is considered. Although finding an experimental model to predict the MALL for real-life process conditions was the ultimate objective, this paper also presents the microbial ingress test data obtained so far for two extreme conditions. Potential constraints, such as vibration, shock, acceleration, liquid movement, and pressure differentials, observed during normal usage were simulated using two extreme differential pressures, 0 mbar and 300 mbar. The estimated MALL for typical use-case conditions are 10-20 µm for storage applications and 2-10 µm for shipping conditions. The microbial integrity test method used in this article was able to detect bacterial ingress down to 3 µm defect size.LAY ABSTRACT: As use of single-use systems (SUSs) is increasingly expanding into all process steps of commercial manufacturing, integrity failure can significantly impact drug safety, availability, and costs. Consequently, growing industry scrutiny on single-use system integrity (SUSI) is raising the need to develop good science behind reliable determinations of liquid leakage and microbial ingress as well as the appropriate physical integrity testing technologies. In the current study, microbial ingress testing by the aerosol method is used to determine the maximum allowable leakage limit (MALL) for SUSs. To define the MALL, it is generally assumed that a system or product will not show any microbial ingress or leakage at a certain defect size. Statistical analysis of the experimental data in this study indicated the MALL with probability at a certain defect size for each system. As a result, the method studied provides a more accurate way of predicting ingress and increasing safety down the line for drug manufacturers and patients alike. CI - © PDA, Inc. 2019. FAU - Aliaskarisohi, Saeedeh AU - Aliaskarisohi S AD - R&D, Sartorius Stedim Biotech GmbH, Goettingen, Germany; saeedeh.aliaskarisohi@sartorius.com. FAU - Hogreve, Marc AU - Hogreve M AD - R&D, Sartorius Stedim Biotech GmbH, Goettingen, Germany. FAU - Langlois, Carole AU - Langlois C AD - Sartorius Stedim Biotech FMT SAS, Aubagne, France; and. FAU - Cutting, Jonathan AU - Cutting J AD - R&D, Sartorius Stedim Inc, Bohemia, NY. FAU - Barbaroux, Magali AU - Barbaroux M AD - Sartorius Stedim Biotech FMT SAS, Aubagne, France; and. FAU - Cappia, Jean-Marc AU - Cappia JM AD - Sartorius Stedim Biotech FMT SAS, Aubagne, France; and. FAU - Menier, Marie-Christine AU - Menier MC AD - Sartorius Stedim Biotech FMT SAS, Aubagne, France; and. LA - eng PT - Journal Article DEP - 20190419 PL - United States TA - PDA J Pharm Sci Technol JT - PDA journal of pharmaceutical science and technology JID - 9439538 RN - 0 (Pharmaceutical Preparations) RN - 0 (Polyvinyls) RN - 24937-78-8 (ethylenevinylacetate copolymer) RN - 9002-88-4 (Polyethylene) RN - Bacillus atrophaeus SB - IM MH - Bacillus/isolation & purification MH - Drug Contamination/*prevention & control MH - *Drug Packaging MH - Pharmaceutical Preparations/*standards MH - Polyethylene/chemistry MH - Polyvinyls/chemistry OTO - NOTNLM OT - Maximum allowable leakage limit (MALL) OT - Microbial ingress testing OT - Single-use system (SUS) OT - Single-use system integrity (SUSI) EDAT- 2019/04/21 06:00 MHDA- 2020/06/06 06:00 CRDT- 2019/04/21 06:00 PHST- 2019/04/21 06:00 [pubmed] PHST- 2020/06/06 06:00 [medline] PHST- 2019/04/21 06:00 [entrez] AID - pdajpst.2018.009688 [pii] AID - 10.5731/pdajpst.2018.009688 [doi] PST - ppublish SO - PDA J Pharm Sci Technol. 2019 Sep-Oct;73(5):459-469. doi: 10.5731/pdajpst.2018.009688. Epub 2019 Apr 19. PMID- 31627916 OWN - NLM STAT- MEDLINE DCOM- 20200120 LR - 20200120 IS - 1873-2623 (Electronic) IS - 0041-1345 (Linking) VI - 51 IP - 9 DP - 2019 Nov TI - False-Positive Tumor During Organ Retrieval: All Cats Are Gray in the Dark. PG - 3034-3036 LID - S0041-1345(19)31179-0 [pii] LID - 10.1016/j.transproceed.2019.08.015 [doi] AB - OBJECTIVE: Efforts to expand the organ donor pool to meet growing transplant demands remains a top priority, as does maintaining the quality and safety standards of potential recipients. There is a short window of time from organ retrieval to decision making on organ acceptance, based on the available data. Furthermore, the limitations of intraoperative biopsy can often lead to donor or organ refusal due to a suspected tumor, which, if not confirmed in the final biopsy, results in the loss of a transplant opportunity. METHODS: Donor characteristics and organs discarded on suspicion of neoplastic disease at the time of extraction were analyzed in Andalusia between January 2014 and July 2018. The variable analysis included sociodemographic data, type of donor, location of the potential malignancy, histopathologic examination, and discarded organs. RESULTS: A total of 43 cases were identified. The organs of 33 donors (76.7%) were discarded. Kidneys were the most frequent location for a suspected tumor (44%), followed by the liver (21%). In 18 of the 43 cases (42%), the suspected malignancy was not confirmed, and of these, only 3 livers and 1 kidney were implanted. Sixty potentially transplantable organs were discarded, including those that would have been extracted and/or implanted in the absence of a suspected tumor. CONCLUSIONS: These results highlight the need not only to improve the accuracy of intraoperative biopsies but to seek new decision-making strategies for the short interval after organ retrieval. This involves avoiding both extremes of donation contraindications, while maintaining quality and safety standards. CI - Copyright © 2019 Elsevier Inc. All rights reserved. FAU - Alvarez-Marquez, Antonia AU - Alvarez-Marquez A AD - Coordinación Autonómica de Trasplantes de Andalucía, Sevilla, Spain. FAU - Castro de la Nuez, Pablo AU - Castro de la Nuez P AD - Coordinación Autonómica de Trasplantes de Andalucía, Sevilla, Spain. FAU - Ruiz-Matas, Jesús Huet AU - Ruiz-Matas JH AD - Coordinación Autonómica de Trasplantes de Andalucía, Sevilla, Spain. FAU - Aunión, Concepción Díaz AU - Aunión CD AD - Coordinación Autonómica de Trasplantes de Andalucía, Sevilla, Spain. FAU - Martín-Villén, Luis AU - Martín-Villén L AD - Coordinación Sectorial de Trasplantes Sevilla-Huelva, Sevilla, Spain. FAU - Dueñas Jurado, José María AU - Dueñas Jurado JM AD - Coordinación Sectorial de Trasplantes Córdoba-Jaén, Córdoba, Spain. FAU - Pérez Villares, José Miguel AU - Pérez Villares JM AD - Coordinación Sectorial de Trasplantes de Granada, Spain. FAU - Egea-Guerrero, Juan José AU - Egea-Guerrero JJ AD - Coordinación Autonómica de Trasplantes de Andalucía, Sevilla, Spain. Electronic address: juanj.egea.sspa@juntadeandalucia.es. LA - eng PT - Journal Article DEP - 20191015 PL - United States TA - Transplant Proc JT - Transplantation proceedings JID - 0243532 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Neoplasms/*diagnosis/*pathology MH - Spain MH - Tissue and Organ Harvesting/*methods MH - Transplants/*pathology/supply & distribution EDAT- 2019/10/20 06:00 MHDA- 2020/01/21 06:00 CRDT- 2019/10/20 06:00 PHST- 2019/10/20 06:00 [pubmed] PHST- 2020/01/21 06:00 [medline] PHST- 2019/10/20 06:00 [entrez] AID - S0041-1345(19)31179-0 [pii] AID - 10.1016/j.transproceed.2019.08.015 [doi] PST - ppublish SO - Transplant Proc. 2019 Nov;51(9):3034-3036. doi: 10.1016/j.transproceed.2019.08.015. Epub 2019 Oct 15. PMID- 34408632 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210820 IS - 1662-5137 (Print) IS - 1662-5137 (Electronic) IS - 1662-5137 (Linking) VI - 15 DP - 2021 TI - Anticonvulsant vs. Proconvulsant Effect of in situ Deep Brain Stimulation at the Epileptogenic Focus. PG - 607450 LID - 10.3389/fnsys.2021.607450 [doi] LID - 607450 AB - Since deep brain stimulation (DBS) at the epileptogenic focus (in situ) denotes long-term repetitive stimulation of the potentially epileptogenic structures, such as the amygdala, the hippocampus, and the cerebral cortex, a kindling effect and aggravation of seizures may happen and complicate the clinical condition. It is, thus, highly desirable to work out a protocol with an evident quenching (anticonvulsant) effect but free of concomitant proconvulsant side effects. We found that in the basolateral amygdala (BLA), an extremely wide range of pulsatile stimulation protocols eventually leads to the kindling effect. Only protocols with a pulse frequency of ≤1 Hz or a direct current (DC), with all of the other parameters unchanged, could never kindle the animal. On the other hand, the aforementioned DC stimulation (DCS), even a pulse as short as 10 s given 5 min before the kindling stimuli or a pulse given even to the contralateral BLA, is very effective against epileptogenicity and ictogenicity. Behavioral, electrophysiological, and histological findings consistently demonstrate success in seizure quenching or suppression as well as in the safety of the specific DBS protocol (e.g., no apparent brain damage by repeated sessions of stimulation applied to the BLA for 1 month). We conclude that in situ DCS, with a novel and rational design of the stimulation protocol composed of a very low (∼3% or 10 s/5 min) duty cycle and assuredly devoid of the potential of kindling, may make a successful antiepileptic therapy with adequate safety in terms of little epileptogenic adverse events and tissue damage. CI - Copyright © 2021 Chou and Kuo. FAU - Chou, Ping AU - Chou P AD - Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan. FAU - Kuo, Chung-Chin AU - Kuo CC AD - Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan. AD - Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. LA - eng PT - Journal Article DEP - 20210802 PL - Switzerland TA - Front Syst Neurosci JT - Frontiers in systems neuroscience JID - 101477946 PMC - PMC8366291 OTO - NOTNLM OT - direct current (DC) OT - in situ DBS OT - kindling OT - mirror focus OT - seizure focus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/08/20 06:00 MHDA- 2021/08/20 06:01 PMCR- 2021/01/01 CRDT- 2021/08/19 06:39 PHST- 2020/09/17 00:00 [received] PHST- 2021/07/05 00:00 [accepted] PHST- 2021/08/19 06:39 [entrez] PHST- 2021/08/20 06:00 [pubmed] PHST- 2021/08/20 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fnsys.2021.607450 [doi] PST - epublish SO - Front Syst Neurosci. 2021 Aug 2;15:607450. doi: 10.3389/fnsys.2021.607450. eCollection 2021. PMID- 14571703 OWN - NLM STAT- MEDLINE DCOM- 20040224 LR - 20041117 IS - 0172-6390 (Print) IS - 0172-6390 (Linking) VI - 50 IP - 53 DP - 2003 Sep-Oct TI - Living related heterotopic auxiliary partial liver transplantation for extremely small-for-size graft in fulminant liver failure. PG - 1220-2 AB - Adult living related liver transplantation seeks a balance between donor safety and the need to save the recipient's life. A small-for-size graft is a major obstacle for high-risk patients. We experienced a case of heterotopic auxiliary partial liver transplantation with extremely small-for-size graft for fulminant liver failure. The other reasons why we chose to perform heterotopic auxiliary partial liver transplantation were acute renal failure, subshock state, and a left lobe volume of 24% in the standard liver volume of the donor. Hepatic vein reconstruction was made using an inferior meserteric vein patch graft. Portal vein reconstruction was made using end-to-side anastomosis employing an interposed left external iliac vein. The left hepatic artery of the graft was connected to the distal gastroduodenal artery. The patient was discharged 3 months after transplantation. We would recommend heterotopic auxiliary partial liver transplantation as an optional procedure for patients with severe preoperative conditions or extremely small-for-size graft donors. FAU - Sato, Yoshinobu AU - Sato Y AD - Division of Digestive and General Surgery, Niigata University Graduate School of Medicine and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan. kanishok@med.niigata-u.ac.jp FAU - Yamamoto, Satoshi AU - Yamamoto S FAU - Takeishi, Toshiyuki AU - Takeishi T FAU - Kobayashi, Takashi AU - Kobayashi T FAU - Kato, Takashi AU - Kato T FAU - Watanabe, Takayuki AU - Watanabe T FAU - Shimamura, Toshihiko AU - Shimamura T FAU - Ichida, Takafumi AU - Ichida T FAU - Hatakeyama, Katsuyoshi AU - Hatakeyama K LA - eng PT - Case Reports PT - Journal Article PL - Greece TA - Hepatogastroenterology JT - Hepato-gastroenterology JID - 8007849 SB - IM MH - Humans MH - Liver Circulation MH - Liver Failure/*surgery MH - Liver Transplantation/*methods MH - *Living Donors MH - Male MH - Middle Aged MH - Portal Pressure MH - *Transplantation, Heterotopic EDAT- 2003/10/24 05:00 MHDA- 2004/02/26 05:00 CRDT- 2003/10/24 05:00 PHST- 2003/10/24 05:00 [pubmed] PHST- 2004/02/26 05:00 [medline] PHST- 2003/10/24 05:00 [entrez] PST - ppublish SO - Hepatogastroenterology. 2003 Sep-Oct;50(53):1220-2. PMID- 2357988 OWN - NLM STAT- MEDLINE DCOM- 19900801 LR - 20190828 IS - 0301-5548 (Print) IS - 0301-5548 (Linking) VI - 60 IP - 4 DP - 1990 TI - Occupational performance of a paced secondary task under conditions of sensory deprivation. I. Heart rate changes in train drivers as a result of monotony. PG - 309-14 AB - Twelve experienced train drivers were asked to operate the train function safety circuit (SIFA)--a paced secondary motor task which is expected to guarantee the driver's fitness for service on engines of the German Federal Railway--under laboratory conditions of extreme monotony. In spite of massive decreases in vigilance as shown by theta-activity in the EEG, all subjects were able to operate the device without major errors. A prerequisite for adequate performance is an EEG-defined arousal reaction, which is synchronized with the SIFA cycles. For 7 subjects the time-related cross-correlation coefficients between SIFA operation, alpha-activity (indicative of alertness), theta-activity (indicative of reduced vigilance), and heart rate were calculated. The central-nervous arousal found in the EEG corresponded to distinct increases in heart rate. The moments of SIFA operation after phases of light sleep correlated significantly and positively with increases in heart rate. These increases constituted a physiological overcompensation as far as the physical readiness was concerned which reached its peak after the task had been performed satisfactorily, constituting additional and superfluous occupational stress. The results of this study indicate clearly that monotony stress is not a result of occupational monotony itself, but the result of the physiological effort which is required in order to regain a level of alterness which allows adequate performance under monotonous conditions. FAU - Peter, J H AU - Peter JH AD - Zeitreihenlabor, Medizinische Poliklinik, Zentrum für Innere Medizin, Marburg, Federal Republic of Germany. FAU - Cassel, W AU - Cassel W FAU - Ehrig, B AU - Ehrig B FAU - Faust, M AU - Faust M FAU - Fuchs, E AU - Fuchs E FAU - Langanke, P AU - Langanke P FAU - Meinzer, K AU - Meinzer K FAU - Pfaff, U AU - Pfaff U LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Germany TA - Eur J Appl Physiol Occup Physiol JT - European journal of applied physiology and occupational physiology JID - 0410266 SB - IM MH - Electroencephalography MH - Environmental Exposure MH - Heart Rate/*physiology MH - Humans MH - Motor Activity/physiology MH - Railroads MH - Random Allocation MH - Sensory Deprivation/*physiology MH - Stress, Physiological/etiology MH - *Task Performance and Analysis OID - NASA: 90292044 EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] AID - 10.1007/BF00379402 [doi] PST - ppublish SO - Eur J Appl Physiol Occup Physiol. 1990;60(4):309-14. doi: 10.1007/BF00379402. PMID- 17112216 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20061120 IS - 1092-0684 (Print) IS - 1092-0684 (Linking) VI - 5 IP - 4 DP - 1998 Oct 15 TI - Safety and efficacy of transluminal balloon angioplasty in the prevention of vasospasm in patients with Fisher Grade 3 subarachnoid hemorrhage: a pilot study. PG - e5 AB - Recent advances in neuroradiology have made it possible to dilate human cerebral arteries that show vasospasm following aneurysmal subarachnoid hemorrhage (SAH), but the time window is short and the success rate for reversal of delayed ischemic neurological deficit (DIND) varies between 31% and 77%. In a canine model of vasospasm, transluminal balloon angioplasty (TBA) performed on Day 0 (the day of aneurysm rupture) has been shown to completely prevent the development of angiographically demonstrated narrowing by Day 7; this effect is better than any pharmacological treatment for vasospasm thus far described. The authors conducted a pilot trial to assess the safety and efficacy of TBA performed within 3 days post-SAH. Twelve patients with a very high probability of developing vasospasm (Fisher Grade 3) were included. Target vessels for prophylactic TBA were the internal carotid artery, A1 segment, M1 segment, and P1 segment bilaterally, the basilar artery, and the vertebral artery. No patient developed DIND or more than mild vasospasm, according to transcranial Doppler criteria. At 3 months, seven patients made a good recovery, two patients were moderately disabled, and three patients died; one patient died because of a vessel rupture during TBA and two older patients died of medical complications associated with an already poor clinical condition at admission. Compared with the results of large series reported in literature of patients with aneurysmal SAH, the results of this pilot study indicate an extremely low incidence of vasospasm and DIND after patients underwent prophylactic TBA. A larger, randomized study, however, is required to determine whether prophylactic TBA is efficacious enough to justify the risks. FAU - Muizelaar, J P AU - Muizelaar JP AD - Departments of Neurological Surgery and Radiology University of California, Davis, Davis, California. FAU - Zwienenberg, M AU - Zwienenberg M FAU - Mini, N A AU - Mini NA FAU - Hecht, S T AU - Hecht ST LA - eng PT - Journal Article PL - United States TA - Neurosurg Focus JT - Neurosurgical focus JID - 100896471 EDAT- 2006/11/23 09:00 MHDA- 2006/11/23 09:01 CRDT- 2006/11/23 09:00 PHST- 2006/11/23 09:00 [pubmed] PHST- 2006/11/23 09:01 [medline] PHST- 2006/11/23 09:00 [entrez] AID - 050405 [pii] PST - ppublish SO - Neurosurg Focus. 1998 Oct 15;5(4):e5. PMID- 38182644 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240108 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Jan 5 TI - Experimental and numerical evaluation for drum dynamic reliability under extremely complex working conditions. PG - 642 LID - 10.1038/s41598-024-51266-6 [doi] LID - 642 AB - Coal mining machine drums are prone to damage and malfunction under extremely complex working conditions, which seriously affects the efficiency and safety of coal production. In this paper, based on the theory of coal rock cutting and virtual simulation technology, finite element models of drum cutting coal rock were established and then verified by physical experiments. Through simulation analysis, the dynamic reliability of the drum was studied from three aspects: load, stress and wear, and a mathematical model of drum load was established with respect to the traction speed and drum rotation speed; based on the orthogonal test, the optimal working parameters to improve the wear resistance of the drum were derived. The results of the study found that when the traction speed increases, the load on the drum increases, and when the drum rotation speed increases, the load on the drum decreases; when the traction speed is increased from 2 to 6 m/min, the stress on the pick body under different rotation speeds increases to different degrees, with an average increase rate of 27.394%; when the drum rotation speed is 90 r/min, the traction speed is 3 m/min, and the coal loading mode is projectile loading, the wear depth of the picks and spiral blades is relatively small. The research method and results of this paper can provide a reference for the selection of the drum working parameters. CI - © 2024. The Author(s). FAU - Zhao, Guochao AU - Zhao G AD - School of Mechanical Engineering, Liaoning Technical University, Fuxin, 123000, China. FAU - Jin, Xin AU - Jin X AD - School of Mechanical Engineering, Liaoning Technical University, Fuxin, 123000, China. jx032615@163.com. FAU - Zhao, Lijuan AU - Zhao L AD - School of Mechanical Engineering, Liaoning Technical University, Fuxin, 123000, China. FAU - Zhou, Wenchao AU - Zhou W AD - 91292 Unit of the People's Liberation Army of China, Beijing, China. FAU - Liu, Xuejing AU - Liu X AD - School of Mechanical Engineering, Liaoning Technical University, Fuxin, 123000, China. LA - eng GR - 52204169/National Natural Science Foundation of China/ GR - 51674134/National Natural Science Foundation of China/ GR - LJKQZ20222321/Liaoning Provincial Education Department Project/ PT - Journal Article DEP - 20240105 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC10770387 COIS- The authors declare no competing interests. EDAT- 2024/01/06 10:41 MHDA- 2024/01/06 10:42 PMCR- 2024/01/05 CRDT- 2024/01/05 23:24 PHST- 2023/09/22 00:00 [received] PHST- 2024/01/03 00:00 [accepted] PHST- 2024/01/06 10:42 [medline] PHST- 2024/01/06 10:41 [pubmed] PHST- 2024/01/05 23:24 [entrez] PHST- 2024/01/05 00:00 [pmc-release] AID - 10.1038/s41598-024-51266-6 [pii] AID - 51266 [pii] AID - 10.1038/s41598-024-51266-6 [doi] PST - epublish SO - Sci Rep. 2024 Jan 5;14(1):642. doi: 10.1038/s41598-024-51266-6. PMID- 38564397 OWN - NLM STAT- MEDLINE DCOM- 20240404 LR - 20240404 IS - 1545-9616 (Print) IS - 1545-9616 (Linking) VI - 23 IP - 4 DP - 2024 Apr 1 TI - Dermatologists' Perspectives on Biosimilars. PG - 277-280 LID - 10.36849/JDD.7755 [doi] AB - Biosimilars are biologic agents the Food and Drug Administration (FDA) has deemed to have no clinical difference from their reference biologics. In dermatology,  biosimilars are approved for the treatment of psoriasis and hidradenitis suppurativa. Although dermatologists are high prescribers of biologics, they are more reluctant to prescribe biosimilars than other specialists. This survey-based study sought to characterize dermatologists’ current perspectives on biosimilars.  Methods: A 27-question survey was distributed via email to dermatologists between September and October of 2022.  Results: Twenty percent of respondents would not prescribe a biosimilar for an FDA-approved indication. When asked about the greatest barriers to biosimilar adoption, 61% had concerns about biosimilar safety and efficacy, 24% reported uncertainty about state laws for interchangeability and substitutions, and 20% had concerns about biosimilar safety without concerns about efficacy. Thirty-five percent of respondents felt moderately or extremely knowledgeable about biosimilar interchangeability.  Conclusion: Biosimilars are safe and effective for treating approved dermatological conditions and may lower patient costs compared to their reference products. Patients are not always offered biosimilar therapy as an option, which may be due to unfamiliarity among dermatologists.  This survey suggests a need for more research and educational initiatives, such as modules and workshops that focus on biosimilar safety, efficacy, and interchangeability guidelines. J Drugs Dermatol. 2024;23(4):doi:10.36849/JDD.7755. FAU - Zameza, Priscila Arellano AU - Zameza PA FAU - Kontzias, Christina AU - Kontzias C FAU - Flanders, Keith AU - Flanders K FAU - Sonnenreich, Peter AU - Sonnenreich P FAU - Feldman, Steven R AU - Feldman SR LA - eng PT - Journal Article PL - United States TA - J Drugs Dermatol JT - Journal of drugs in dermatology : JDD JID - 101160020 RN - 0 (Biosimilar Pharmaceuticals) SB - IM MH - Humans MH - *Biosimilar Pharmaceuticals/adverse effects MH - Dermatologists MH - *Psoriasis/drug therapy MH - Surveys and Questionnaires MH - *Hidradenitis Suppurativa/drug therapy EDAT- 2024/04/02 18:44 MHDA- 2024/04/04 06:44 CRDT- 2024/04/02 13:11 PHST- 2024/04/04 06:44 [medline] PHST- 2024/04/02 18:44 [pubmed] PHST- 2024/04/02 13:11 [entrez] AID - S1545961624P0277X [pii] AID - 10.36849/JDD.7755 [doi] PST - ppublish SO - J Drugs Dermatol. 2024 Apr 1;23(4):277-280. doi: 10.36849/JDD.7755. PMID- 34681110 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211026 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 10 IP - 10 DP - 2021 Oct 8 TI - Tegafur-Uracil versus 5-Fluorouracil in Combination with Cisplatin and Cetuximab in Elderly Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Propensity Score Matching Analysis. LID - 10.3390/biology10101011 [doi] LID - 1011 AB - There are increasing incidences of elderly patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). However, the treatment is not yet established. We conducted a propensity score matching analysis to evaluate the efficacy and safety of tegafur-uracil versus 5-fluorouracil in combination with cisplatin plus cetuximab in elderly patients with R/M HNSCC. Elderly patients with R/M HNSCC treated with cetuximab-containing chemotherapy were recruited into this study. In order to reduce the selection bias, propensity score matching was performed. Kaplan-Meier curves were plotted for progression-free survival (PFS) and overall survival (OS). Toxicities were graded according to the National Cancer Institute's Common Terminology Criteria V3.0. After propensity sore matching, 54 patients with tegafur-uracil, cisplatin plus cetuximab (UPEx), and 54 patients with 5-fluorouracil, cisplatin plus cetuximab (EXTREME) were identified. The median PFS was 5.4 months in UPEx and 5.8 months in EXTREME (p = 0.451). The median OS was 10.8 months in UPEx and 10.2 months in EXTREME (p = 0.807). The overall response rate (ORR) and disease control rate (DCR) were insignificant in both arms, accounting for 61% versus 59% (p = 0.680) and 72% versus 70% (p = 0.732) in the UPEx arm and the EXTREME arm, respectively. A multivariate analysis showed that age and ECOG PS were, independently, predictors. Grade 3/4 adverse events were much fewer in UPEx than in EXTREME (p < 0.001). Both cetuximab-containing chemotherapies are effective in elderly patients with R/M HNSCC. Safety profiles are improved when tegafur-uracil is substituted for 5-fluorouracil. Further prospective studies are warranted to validate our conclusions. FAU - Hsieh, Meng-Che AU - Hsieh MC AD - Department of Hematology-Oncology, E-Da Cancer Hospital, Kaohsiung City 82445, Taiwan. AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. FAU - Wang, Chih-Chun AU - Wang CC AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Hospital, Kaohsiung City 82445, Taiwan. FAU - Yang, Chuan-Chien AU - Yang CC AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Hospital, Kaohsiung City 82445, Taiwan. FAU - Lien, Ching-Feng AU - Lien CF AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Hospital, Kaohsiung City 82445, Taiwan. FAU - Wang, Chien-Chung AU - Wang CC AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Hospital, Kaohsiung City 82445, Taiwan. FAU - Shih, Yu-Chen AU - Shih YC AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Cancer Hospital, Kaohsiung City 82445, Taiwan. FAU - Yeh, Shyh-An AU - Yeh SA AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Radiation Oncology, E-Da Hospital, Kaohsiung City 82445, Taiwan. FAU - Hwang, Tzer-Zen AU - Hwang TZ AD - College of Medicine, I-Shou University, Kaohsiung City 82445, Taiwan. AD - Department of Otolaryngology, E-Da Hospital, Kaohsiung City 82445, Taiwan. LA - eng PT - Journal Article DEP - 20211008 PL - Switzerland TA - Biology (Basel) JT - Biology JID - 101587988 PMC - PMC8533478 OTO - NOTNLM OT - cetuximab OT - elderly patients OT - recurrent or metastatic head and neck squamous cell carcinoma OT - survival OT - tegafur–uracil COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/10/24 06:00 MHDA- 2021/10/24 06:01 PMCR- 2021/10/08 CRDT- 2021/10/23 01:06 PHST- 2021/09/15 00:00 [received] PHST- 2021/10/04 00:00 [revised] PHST- 2021/10/05 00:00 [accepted] PHST- 2021/10/23 01:06 [entrez] PHST- 2021/10/24 06:00 [pubmed] PHST- 2021/10/24 06:01 [medline] PHST- 2021/10/08 00:00 [pmc-release] AID - biology10101011 [pii] AID - biology-10-01011 [pii] AID - 10.3390/biology10101011 [doi] PST - epublish SO - Biology (Basel). 2021 Oct 8;10(10):1011. doi: 10.3390/biology10101011. PMID- 39770618 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250108 IS - 2076-2607 (Print) IS - 2076-2607 (Electronic) IS - 2076-2607 (Linking) VI - 12 IP - 12 DP - 2024 Nov 25 TI - Effects of Increasing Temperature on Bacterial Community Diversity in Mixed Stands of Artemisia argyi and Solidago canadensis in Eastern China. LID - 10.3390/microorganisms12122415 [doi] LID - 2415 AB - Global climate change and invasive plants significantly impact biodiversity and ecosystem functions. This study focuses on the effects of progressive warming on microbial communities within the Solidago canadensis invasion community, simulated through six stages of invasion progression, from minimal to dominant S. canadensis presence alongside native Artemisia argyi, in bulk soils collected from a natural habitat and cultivated under controlled greenhouse conditions. Utilizing high-throughput sequencing and microbial community analysis on 72 samples collected from the S. canadensis invasion community, the shifts in soil microbiota under varying warming scenarios were investigated (+0 °C, +1.15 °C and +1.86 °C). We observed significant shifts in invasion community soil bacteria in response to warming, with Acidobacteria, Actinobacteria, and others showing distinct responses between baseline and warmed conditions, while groups like Chlorobi and Cyanobacteria only differed significantly at higher temperature extremes. The random forests algorithm identified 14 taxa as biomarkers and a model was established to correlate S. canadensis invasion community soil microbiota with progressive warming. Co-occurrence network analysis revealed that moderate warming enhances microbial connectivity and the presence of a super-generalist, ASV 1160. However, further warming disrupts these networks by eliminating key generalists, revealing a potential reduction in network stability and diversity. These findings illuminate the dynamic responses of microbes in S. canadensis invasion community soil to varying temperature regimes, suggesting a model for successional dynamics and offering a deeper comprehension of microbial community shifts amid climatic fluctuations. This study delineates how warming significantly reshapes the soil microbial composition, potentially impacting S. canadensis's invasion success unfavorably, thereby highlighting the importance of considering microbial dynamics in ecological management. FAU - Yu, Haochen AU - Yu H AUID- ORCID: 0009-0004-1749-4673 AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. FAU - Ren, Guangqian AU - Ren G AUID- ORCID: 0009-0007-7059-9206 AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. AD - Jiangsu Province Engineering Research Center of Green Technology and Contingency Management for Emerging Pollutants, Jiangsu University, Zhenjiang 212013, China. FAU - Huang, Zhiyun AU - Huang Z AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. FAU - Qi, Shanshan AU - Qi S AD - School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China. FAU - Zhao, Biying AU - Zhao B AD - International Genome Centre, Jiangsu University, Zhenjiang 212013, China. FAU - Fan, Xue AU - Fan X AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. FAU - Zhu, Zhaoqi AU - Zhu Z AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. FAU - Dai, Zhicong AU - Dai Z AUID- ORCID: 0000-0002-0748-8059 AD - School of Emergency Management, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. AD - Jiangsu Province Engineering Research Center of Green Technology and Contingency Management for Emerging Pollutants, Jiangsu University, Zhenjiang 212013, China. AD - Institute of Environment and Ecology, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. AD - Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China. FAU - Du, Daolin AU - Du D AD - Jingjiang College, Jiangsu University, Zhenjiang 212013, China. LA - eng GR - 32071521/National Natural Science Foundation of China/ PT - Journal Article DEP - 20241125 PL - Switzerland TA - Microorganisms JT - Microorganisms JID - 101625893 PMC - PMC11677931 OTO - NOTNLM OT - co-occurrence network OT - plant invasion community OT - random forest OT - soil bacteria COIS- The authors declare no conflicts of interest. EDAT- 2025/01/08 06:21 MHDA- 2025/01/08 06:22 PMCR- 2024/11/25 CRDT- 2025/01/08 01:32 PHST- 2024/09/30 00:00 [received] PHST- 2024/11/22 00:00 [revised] PHST- 2024/11/22 00:00 [accepted] PHST- 2025/01/08 06:22 [medline] PHST- 2025/01/08 06:21 [pubmed] PHST- 2025/01/08 01:32 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - microorganisms12122415 [pii] AID - microorganisms-12-02415 [pii] AID - 10.3390/microorganisms12122415 [doi] PST - epublish SO - Microorganisms. 2024 Nov 25;12(12):2415. doi: 10.3390/microorganisms12122415. PMID- 34138267 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210624 IS - 2150-5551 (Electronic) IS - 2311-6706 (Print) IS - 2150-5551 (Linking) VI - 12 IP - 1 DP - 2020 Mar 19 TI - High-Voltage Flexible Aqueous Zn-Ion Battery with Extremely Low Dropout Voltage and Super-Flat Platform. PG - 75 LID - 10.1007/s40820-020-0414-6 [doi] LID - 75 AB - Flexible rechargeable aqueous zinc-ion batteries (ZIBs) have attracted extensive attentions in the energy storage field due to their high safety, environmental friendliness, and outstanding electrochemical performance while the exploration of high-voltage aqueous ZIBs with excellent rate capability is still a great challenge for the further application them in flexible and wearable electronics. Herein, we fabricated a 2.4 V high-voltage flexible aqueous ZIB, being among the highest voltage reported in aqueous ZIBs. Moreover, it exhibits extremely flat charging/discharging voltage platforms and the dropout voltage is only 0.1 V, which is the smallest gap in all aqueous batteries to our best knowledge. Furthermore, the prepared ZIB performs high rate capability of 25 C and energy density of 120 Wh kg(-1) and exhibits excellent safety under various destructive conditions including hammering, sewing, punching, and soaking. These extraordinary results indicate the great application potential of our high-voltage flexible aqueous ZIB in wearable electronics. FAU - Chen, Zhe AU - Chen Z AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Wang, Panpan AU - Wang P AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Ji, Zhenyuan AU - Ji Z AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Wang, Hua AU - Wang H AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Liu, Jie AU - Liu J AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Wang, Jiaqi AU - Wang J AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Hu, Mengmeng AU - Hu M AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. FAU - Huang, Yan AU - Huang Y AD - State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. yanhuanglib@hit.edu.cn. AD - Flexible Printed Electronic Technology Center, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. yanhuanglib@hit.edu.cn. AD - School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, People's Republic of China. yanhuanglib@hit.edu.cn. LA - eng PT - Journal Article DEP - 20200319 PL - Germany TA - Nanomicro Lett JT - Nano-micro letters JID - 101727940 PMC - PMC7770716 OTO - NOTNLM OT - Aqueous zinc-ion battery OT - Flat platform OT - Flexible OT - High voltage OT - Rate capability EDAT- 2020/03/19 00:00 MHDA- 2020/03/19 00:01 PMCR- 2020/03/19 CRDT- 2021/06/17 12:50 PHST- 2019/12/28 00:00 [received] PHST- 2020/02/21 00:00 [accepted] PHST- 2021/06/17 12:50 [entrez] PHST- 2020/03/19 00:00 [pubmed] PHST- 2020/03/19 00:01 [medline] PHST- 2020/03/19 00:00 [pmc-release] AID - 10.1007/s40820-020-0414-6 [pii] AID - 414 [pii] AID - 10.1007/s40820-020-0414-6 [doi] PST - epublish SO - Nanomicro Lett. 2020 Mar 19;12(1):75. doi: 10.1007/s40820-020-0414-6. PMID- 32038560 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 10 DP - 2019 TI - The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors in Streptomyces and Related Actinobacteria. PG - 3120 LID - 10.3389/fmicb.2019.03120 [doi] LID - 3120 AB - Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key nutrients result in an unbalanced metabolism that have undesirable consequences for growth, cell differentiation, reproduction, and secondary metabolites biosynthesis. In the last decades evidence has accumulated indicating that mechanisms to correct metabolic unbalances in Streptomyces species take place at the transcriptional level, mediated by different transcriptional factors. For example, the master regulator PhoP and the large SARP-type regulator AfsR bind to overlapping sequences in the afsS promoter and, therefore, compete in the integration of signals of phosphate starvation and S-adenosylmethionine (SAM) concentrations. The cross-talk between phosphate control of metabolism, mediated by the PhoR-PhoP system, and the pleiotropic orphan nitrogen regulator GlnR, is very interesting; PhoP represses GlnR and other nitrogen metabolism genes. The mechanisms of control by GlnR of several promoters of ATP binding cassettes (ABC) sugar transporters and carbon metabolism are highly elaborated. Another important cross-talk that governs nitrogen metabolism involves the competition between GlnR and the transcriptional factor MtrA. GlnR and MtrA exert opposite effects on expression of nitrogen metabolism genes. MtrA, under nitrogen rich conditions, represses expression of nitrogen assimilation and regulatory genes, including GlnR, and competes with GlnR for the GlnR binding sites. Strikingly, these sites also bind to PhoP. Novel examples of interacting transcriptional factors, discovered recently, are discussed to provide a broad view of this interactions. Altogether, these findings indicate that cross-talks between the major transcriptional factors protect the cell metabolic balance. A detailed analysis of the transcriptional factors binding sequences suggests that the transcriptional factors interact with specific regions, either by overlapping the recognition sequence of other factors or by binding to adjacent sites in those regions. Additional interactions on the regulatory backbone are provided by sigma factors, highly phosphorylated nucleotides, cyclic dinucleotides, and small ligands that interact with cognate receptor proteins and with TetR-type transcriptional regulators. We propose to define the signal integration DNA regions (so called integrator sites) that assemble responses to different stress, nutritional or environmental signals. These integrator sites constitute nodes recognized by two, three, or more transcriptional factors to compensate the unbalances produced by metabolic stresses. This interplay mechanism acts as a safety net to prevent major damage to the metabolism under extreme nutritional and environmental conditions. CI - Copyright © 2020 Martín and Liras. FAU - Martín, Juan F AU - Martín JF AD - Área de Microbiología, Departamento de Biología Molecular, Universidad de León, León, Spain. FAU - Liras, Paloma AU - Liras P AD - Área de Microbiología, Departamento de Biología Molecular, Universidad de León, León, Spain. LA - eng PT - Journal Article PT - Review DEP - 20200122 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC6988585 OTO - NOTNLM OT - Actinobacteria OT - cyclic nucleotides OT - overlapping binding sequences OT - safety net OT - sigma factors OT - signal integration nodes OT - stress signals OT - transcriptional factors EDAT- 2020/02/11 06:00 MHDA- 2020/02/11 06:01 PMCR- 2020/01/22 CRDT- 2020/02/11 06:00 PHST- 2019/11/04 00:00 [received] PHST- 2019/12/24 00:00 [accepted] PHST- 2020/02/11 06:00 [entrez] PHST- 2020/02/11 06:00 [pubmed] PHST- 2020/02/11 06:01 [medline] PHST- 2020/01/22 00:00 [pmc-release] AID - 10.3389/fmicb.2019.03120 [doi] PST - epublish SO - Front Microbiol. 2020 Jan 22;10:3120. doi: 10.3389/fmicb.2019.03120. eCollection 2019. PMID- 36890278 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230309 LR - 20240914 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 13 IP - 1 DP - 2023 Mar 8 TI - Safety level assessment of shield tunneling in water rich sandy pebble strata with large particle size. PG - 3854 LID - 10.1038/s41598-023-30718-5 [doi] LID - 3854 AB - Shield tunneling method is widely used in urban metro construction. The construction stability is closely related to the engineering geological conditions. Sandy pebble strata have a loose structure and low cohesion, resulting in great engineering-induced stratigraphic disturbance. Meanwhile, the high water-abundance and strong permeability are extremely detrimental to construction safety. It is of great significance to evaluate the dangerousness of shield tunneling in water-rich pebble strata with large particle size. In this paper, risk assessment of engineering practice is carried through with Chengdu metro project in China as a case study. Referring to the special engineering situations and assessment workload, seven evaluation indices, including compressive strength of pebble layer, boulder volume content, permeability coefficient, groundwater depth, grouting pressure, tunneling speed and tunnel buried depth are selected to establish an evaluation system. A complete risk assessment framework is established based on the cloud model, AHP and entropy weight method. Further, the measured surface settlement is taken as the risk degree characterization to verify the results. This study can provide reference for method selection and evaluation system establishment in the risk assessment of shield tunnel construction in water-rich sandy pebble strata, and contribute to proposing safety management in similar engineering projects. CI - © 2023. The Author(s). FAU - Yao, Peiyi AU - Yao P AD - Construction Engineering College, Jilin University, Changchun, 130026, Jilin, China. FAU - Yu, Ziwang AU - Yu Z AD - Construction Engineering College, Jilin University, Changchun, 130026, Jilin, China. FAU - Lv, Yan AU - Lv Y AD - Construction Engineering College, Jilin University, Changchun, 130026, Jilin, China. lvyy@jlu.edu.cn. FAU - Shi, Bin AU - Shi B AD - Construction Engineering College, Jilin University, Changchun, 130026, Jilin, China. FAU - He, Yuanyuan AU - He Y AD - Construction Engineering College, Jilin University, Changchun, 130026, Jilin, China. FAU - Wang, Hong AU - Wang H AD - College of Civil Engineering, Guizhou University, Guiyang, 550025, Guizhou, China. FAU - Liu, Danna AU - Liu D AD - China Communication North Road and Bridge Co., Ltd., Beijing, 100024, China. FAU - Wei, Shengda AU - Wei S AD - China Communication North Road and Bridge Co., Ltd., Beijing, 100024, China. LA - eng PT - Journal Article DEP - 20230308 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC9995358 COIS- The authors declare no competing interests. EDAT- 2023/03/09 06:00 MHDA- 2023/03/09 06:01 PMCR- 2023/03/08 CRDT- 2023/03/08 23:20 PHST- 2022/11/16 00:00 [received] PHST- 2023/02/28 00:00 [accepted] PHST- 2023/03/08 23:20 [entrez] PHST- 2023/03/09 06:00 [pubmed] PHST- 2023/03/09 06:01 [medline] PHST- 2023/03/08 00:00 [pmc-release] AID - 10.1038/s41598-023-30718-5 [pii] AID - 30718 [pii] AID - 10.1038/s41598-023-30718-5 [doi] PST - epublish SO - Sci Rep. 2023 Mar 8;13(1):3854. doi: 10.1038/s41598-023-30718-5. PMID- 33412078 OWN - NLM STAT- MEDLINE DCOM- 20210422 LR - 20210422 IS - 1744-764X (Electronic) IS - 1474-0338 (Linking) VI - 20 IP - 3 DP - 2021 Mar TI - Use of medications during pregnancy and breastfeeding for Crohn's disease and ulcerative colitis. PG - 275-292 LID - 10.1080/14740338.2021.1873948 [doi] AB - Introduction: The peak age of diagnosis of inflammatory bowel disease (IBD) occurs during childbearing years, therefore management of IBD during pregnancy is a frequent occurrence. Maintenance of disease remission is crucial to optimize pregnancy outcomes, and potential maternal or fetal toxicity from medications must be balanced against the risks of untreated IBD.Areas covered: This review summarizes the literature on safety and use of medications for IBD during pregnancy and lactation.Expert opinion: 5-aminosalicylates, corticosteroids and thiopurines are safe for use during pregnancy, while methotrexate and tofacitinib should only be used with extreme caution. Anti-TNF agents (except certolizumab), vedolizumab, ustekinumab and tofacitinib readily traverse the placenta via active transport, therefore theoretically may affect fetal development. Certolizumab only undergoes passive transfer across the placenta, thus has markedly lower cord blood levels making it likely the safest biologic agent for infants. There is reasonable evidence to support the safety of anti-TNF monotherapy and combination therapy during pregnancy and lactation. Vedolizumab and ustekinumab are also thought to be safe in pregnancy and lactation, while tofacitinib is generally avoided due to teratogenic effects in animal studies. FAU - Laube, Robyn AU - Laube R AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. AD - Department of Gastroenterology, Macquarie University Hospital, Sydney, Australia. FAU - Paramsothy, Sudarshan AU - Paramsothy S AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. AD - Department of Gastroenterology, Macquarie University Hospital, Sydney, Australia. AD - Department of Gastroenterology and Hepatology, Concord Repatriation General Hospital, Sydney, Australia. FAU - Leong, Rupert W AU - Leong RW AD - Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia. AD - Department of Gastroenterology, Macquarie University Hospital, Sydney, Australia. AD - Department of Gastroenterology and Hepatology, Concord Repatriation General Hospital, Sydney, Australia. LA - eng PT - Journal Article PT - Review DEP - 20210205 PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - 0 (Biological Factors) RN - 0 (Gastrointestinal Agents) SB - IM MH - Animals MH - Biological Factors/administration & dosage/adverse effects MH - Colitis, Ulcerative/*drug therapy MH - Crohn Disease/*drug therapy MH - Female MH - Gastrointestinal Agents/*administration & dosage/adverse effects MH - Humans MH - Lactation MH - Placenta/metabolism MH - Pregnancy MH - Pregnancy Complications/drug therapy OTO - NOTNLM OT - Inflammatory bowel disease OT - biologic therapy OT - breastfeeding OT - immunosuppression OT - medication safety OT - pregnancy EDAT- 2021/01/08 06:00 MHDA- 2021/04/23 06:00 CRDT- 2021/01/07 20:10 PHST- 2021/01/08 06:00 [pubmed] PHST- 2021/04/23 06:00 [medline] PHST- 2021/01/07 20:10 [entrez] AID - 10.1080/14740338.2021.1873948 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2021 Mar;20(3):275-292. doi: 10.1080/14740338.2021.1873948. Epub 2021 Feb 5. PMID- 35068404 OWN - NLM STAT- MEDLINE DCOM- 20221215 LR - 20240221 IS - 1559-6834 (Electronic) IS - 0899-823X (Print) IS - 0899-823X (Linking) VI - 43 IP - 12 DP - 2022 Dec TI - Association between prevalence of laboratory-identified Clostridioides difficile infection (CDI) and antibiotic treatment for CDI in US acute-care hospitals, 2019. PG - 1847-1852 LID - 10.1017/ice.2022.6 [doi] AB - OBJECTIVE: To evaluate hospital-level variation in using first-line antibiotics for Clostridioides difficile infection (CDI) based on the burden of laboratory-identified (LabID) CDI. METHODS: Using data on hospital-level LabID CDI events and antimicrobial use (AU) for CDI (oral/rectal vancomycin or fidaxomicin) submitted to the National Healthcare Safety Network in 2019, we assessed the association between hospital-level CDI prevalence (per 100 patient admissions) and rate of CDI AU (days of therapy per 1,000 days present) to generate a predicted value of AU based on CDI prevalence and CDI test type using negative binomial regression. The ratio of the observed to predicted AU was then used to identify hospitals with extreme discordance between CDI prevalence and CDI AU, defined as hospitals with a ratio outside of the intervigintile range. RESULTS: Among 963 acute-care hospitals, rate of CDI prevalence demonstrated a positive dose-response relationship with rate of CDI AU. Compared with hospitals without extreme discordance (n = 902), hospitals with lower-than-expected CDI AU (n = 31) had, on average, fewer beds (median, 106 vs 208), shorter length of stay (median, 3.8 vs 4.2 days), and higher proportion of undergraduate or nonteaching medical school affiliation (48% vs 39%). Hospitals with higher-than-expected CDI AU (n = 30) were similar overall to hospitals without extreme discordance. CONCLUSIONS: The prevalence rate of LabID CDI had a significant dose-response association with first-line antibiotics for treating CDI. We identified hospitals with extreme discordance between CDI prevalence and CDI AU, highlighting potential opportunities for data validation and improvements in diagnostic and treatment practices for CDI. FAU - Xu, Kerui AU - Xu K AUID- ORCID: 0000-0002-4230-4980 AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Wu, Hsiu AU - Wu H AUID- ORCID: 0000-0002-4195-7162 AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Li, Qunna AU - Li Q AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Edwards, Jonathan R AU - Edwards JR AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - O'Leary, Erin N AU - O'Leary EN AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Leaptrot, Denise AU - Leaptrot D AUID- ORCID: 0000-0003-2461-208X AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. FAU - Benin, Andrea L AU - Benin AL AD - Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States PT - Journal Article DEP - 20220124 PL - United States TA - Infect Control Hosp Epidemiol JT - Infection control and hospital epidemiology JID - 8804099 RN - 0 (Anti-Bacterial Agents) RN - 6Q205EH1VU (Vancomycin) SB - IM MH - Humans MH - *Clostridioides difficile MH - Prevalence MH - *Cross Infection/drug therapy/epidemiology MH - *Clostridium Infections/drug therapy/epidemiology MH - Anti-Bacterial Agents/therapeutic use MH - Vancomycin/therapeutic use MH - Hospitals PMC - PMC10877317 MID - NIHMS1963915 OTO - NOTNLM OT - Clostridioidesdifficile OT - National Healthcare Safety Network OT - antibiotics OT - antimicrobial use COIS- Conflicts of interest. All authors report no conflicts of interest relevant to this article. EDAT- 2022/01/25 06:00 MHDA- 2022/12/16 06:00 PMCR- 2024/02/20 CRDT- 2022/01/24 08:45 PHST- 2022/01/25 06:00 [pubmed] PHST- 2022/12/16 06:00 [medline] PHST- 2022/01/24 08:45 [entrez] PHST- 2024/02/20 00:00 [pmc-release] AID - S0899823X2200006X [pii] AID - 10.1017/ice.2022.6 [doi] PST - ppublish SO - Infect Control Hosp Epidemiol. 2022 Dec;43(12):1847-1852. doi: 10.1017/ice.2022.6. Epub 2022 Jan 24. PMID- 34492912 OWN - NLM STAT- MEDLINE DCOM- 20210920 LR - 20210920 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 416 DP - 2021 Aug 15 TI - Support promotion effect on the SO(2) and K(+) co-poisoning resistance of MnO(2)/TiO(2) for NH(3)-SCR of NO. PG - 126117 LID - S0304-3894(21)01081-5 [pii] LID - 10.1016/j.jhazmat.2021.126117 [doi] AB - Mn-based catalysts are expected to be applied for removing NO(x) due to its excellent low-temperature activity. However, the practical use of these catalysts is extremely restricted with the co-poisoning of alkali metal and SO(2) in the flue gas. Here the MnO(2)/TiO(2) catalyst was employed to elucidate the co-poisoning mechanisms of K and SO(2) for the low temperature selective catalytic reduction (SCR) of NO. The physicochemical properties of catalysts under different toxicity conditions were studied by experiments. The adsorption of NH(3), SO(2), NO, and K on active component (MnO(2)) and support (TiO(2)) was studied by density functional theory. This work unravels a promotion effect of support on the alkali and sulfur resistance. The SO(2)&K co-poisoning catalyst had higher SCR activity than the SO(2)-poisoned and K-poisoned catalyst alone. For a single toxic condition: (1) SO(2) was preferentially bonded with the terminated O site of MnO(2) inhibiting the dehydrogenation of NH(3) and redox cycle. (2) The presence of Lewis base (K atom) on the catalyst decreased the binding energy of a Lewis base (NH(3)) and hindered the adsorption of NH(3). For the synergistic effect of K and SO(2), the majority of K adsorbed on the support (TiO(2)) lead to increase alkalinity, which could promote the adsorption of SO(2) on the TiO(2) and reduce the toxicity of the active component (MnO(2)). CI - Copyright © 2021 Elsevier B.V. All rights reserved. FAU - Wei, Lu AU - Wei L AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China; Faculty of Materials and Manufacturing, Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing 100124, China. FAU - Wang, Zhiwei AU - Wang Z AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China. FAU - Liu, Yuxi AU - Liu Y AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China. FAU - Guo, Guangsheng AU - Guo G AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China. FAU - Dai, Hongxing AU - Dai H AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China. FAU - Cui, Suping AU - Cui S AD - Faculty of Materials and Manufacturing, Key Laboratory of Advanced Functional Materials, Ministry of Education, Beijing University of Technology, Beijing 100124, China. FAU - Deng, Jiguang AU - Deng J AD - Key Laboratory of Beijing on Regional Air Pollution Control, Beijing Key Laboratory for Green Catalysis and Separation, Center of Excellence for Environmental Safety and Biological Effects, Beijing University of Technology, Beijing 100124, China. Electronic address: jgdeng@bjut.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210524 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Manganese Compounds) RN - 0 (Oxides) RN - 15FIX9V2JP (titanium dioxide) RN - 7664-41-7 (Ammonia) RN - D1JT611TNE (Titanium) SB - IM MH - *Ammonia MH - Catalysis MH - *Manganese Compounds MH - Oxidation-Reduction MH - Oxides MH - Titanium OTO - NOTNLM OT - Alkali metal and SO(2) poisoning OT - Catalyst deactivation mechanism OT - MnO(2)/TiO(2) OT - NH(3)-SCR EDAT- 2021/09/09 06:00 MHDA- 2021/09/21 06:00 CRDT- 2021/09/08 01:02 PHST- 2021/02/07 00:00 [received] PHST- 2021/04/28 00:00 [revised] PHST- 2021/05/11 00:00 [accepted] PHST- 2021/09/08 01:02 [entrez] PHST- 2021/09/09 06:00 [pubmed] PHST- 2021/09/21 06:00 [medline] AID - S0304-3894(21)01081-5 [pii] AID - 10.1016/j.jhazmat.2021.126117 [doi] PST - ppublish SO - J Hazard Mater. 2021 Aug 15;416:126117. doi: 10.1016/j.jhazmat.2021.126117. Epub 2021 May 24. PMID- 28810964 OWN - NLM STAT- MEDLINE DCOM- 20180521 LR - 20180921 IS - 1930-613X (Electronic) IS - 0026-4075 (Linking) VI - 182 IP - 7 DP - 2017 Jul TI - A Study on the Tactical Safety of Endotracheal Intubation Under Darkness. PG - e1722-e1725 LID - 10.7205/MILMED-D-16-00407 [doi] AB - OBJECTIVE: Strict blackout discipline is extremely important for all military units. To be able to effectively determine wound characteristics and perform the necessary interventions at nighttime, vision and light restrictions can be mitigated through the use of tactical night vision goggles (NVGs). The lamp of the classical laryngoscope (CL) can be seen with the naked eye; infrared light, on the other hand, cannot be perceived without the use of NVGs. The aim of the study is to evaluate the safety of endotracheal intubation (ETI) procedures in the dark under tactically safe conditions with modified laryngoscope (ML) model. METHODS: We developed an ML model by changing the standard lamp on a CL with an infrared light-emitting diode lamp to obtain a tool which can be used to perform ETI under night conditions in combination with NVGs. We first evaluated the safety of ETI procedures in prehospital conditions under darkness by using both the CL and the ML for the study, and then researched the procedures and methods by which ETI procedure could be performed in the dark under tactically safe conditions. In addition, to better ensure light discipline in the field of combat, we also researched the benefits, from a light discipline standpoint, of using the poncho liner (PL) and of taking advantage of the oropharyngeal region during ETIs performed by opening the laryngoscope blades directly in the mouth and using a cover. During the ETI procedures performed on the field, two experienced combatant staff simulated the enemy by determining whether the light from the two different types of laryngoscope could be seen at 100-m intervals up to 1,500 m. RESULTS: In all scenarios, performing observations with an NVG was more advantageous for the enemy than with the naked eye. The best measure that can be taken against this threat by the paramedic is to ensure tactical safety by having an ML and by opening the ML inside the mouth with the aid of a PL. The findings of the study are likely to shed light on the tactical safety of ETI performed with NVGs under darkness. CONCLUSION: Considering this finding, we still strongly recommend that it would be relatively safer to open the ML blade inside the mouth and to perform the procedures under a PL. In chaotic environments where it might become necessary to provide civilian health services for humanitarian aid purposes (Red Crescent, Red Cross, etc.) without NVGs, we believe that it would be relatively safer to open the CL blade inside the mouth and to perform the procedures under a PL. CI - Reprint & Copyright © 2017 Association of Military Surgeons of the U.S. FAU - Bilge, Sedat AU - Bilge S AD - Department of Emergency Medicine, Gülhane Research and Training Hospital, General Tevfik Saglam Street, Etlik, Ankara 06010, Turkey. FAU - Aydin, Attila AU - Aydin A AD - Department of Emergency Medicine, Gülhane Research and Training Hospital, General Tevfik Saglam Street, Etlik, Ankara 06010, Turkey. FAU - Bilge, Meltem AU - Bilge M AD - Clinic of Anesthesia and Resuscitation, Dışkapı Research and Training Hospital, Dışkapı, Ulus, Ankara 06010, Turkey. FAU - Aydin, Cemile AU - Aydin C AD - Department of Internal Medicine, Etimesgut State Hospital, Etimesgut, Ankara 06010, Turkey. FAU - Cevik, Erdem AU - Cevik E AD - Department of Emergency Medicine, Sultan Abdülhamid Research and Training Hospital, Haydarpaşa, Istanbul 02016, Turkey. FAU - Eryilmaz, Mehmet AU - Eryilmaz M AD - Department of Emergency Medicine, Gülhane Research and Training Hospital, General Tevfik Saglam Street, Etlik, Ankara 06010, Turkey. LA - eng PT - Journal Article PL - England TA - Mil Med JT - Military medicine JID - 2984771R SB - IM MH - Darkness/*adverse effects MH - Humans MH - Intubation, Intratracheal/*methods/*standards MH - Laryngoscopes/adverse effects/trends MH - Military Personnel/education MH - Night Vision MH - Warfare EDAT- 2017/08/16 06:00 MHDA- 2018/05/22 06:00 CRDT- 2017/08/17 06:00 PHST- 2017/08/17 06:00 [entrez] PHST- 2017/08/16 06:00 [pubmed] PHST- 2018/05/22 06:00 [medline] AID - 10.7205/MILMED-D-16-00407 [doi] PST - ppublish SO - Mil Med. 2017 Jul;182(7):e1722-e1725. doi: 10.7205/MILMED-D-16-00407. PMID- 35267397 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 11 IP - 5 DP - 2022 Mar 7 TI - Recovery of Pasteurization-Resistant Vibrio parahaemolyticus from Seafoods Using a Modified, Two-Step Enrichment. LID - 10.3390/foods11050764 [doi] LID - 764 AB - Persistent Vibrio-parahaemolyticus-associated vibriosis cases, attributed, in part, to the inefficient techniques for detecting viable-but-non-culturable (VBNC) Vibrio pathogens and the ingestion of undercooked seafood, is the leading cause of bacterial seafood-borne outbreaks, hospitalizations, and deaths in the United States. The effect of extreme heat processing on Vibrio biology and its potential food safety implication has been underexplored. In the present work, environmental samples from the wet market, lagoon, and estuarine environments were analyzed for V. parahaemolyticus recovery using a modified, temperature-dependent, two-step enrichment method followed by culture-based isolation, phenotype, and genotype characterizations. The work recovered novel strains (30% of 12 isolates) of V. parahaemolyticus from prolonged-heat-processing conditions (80 °C, 20 min), as confirmed by 16S rDNA bacterial identification. Select strains, VHT1 and VHT2, were determined to be hemolysis- and urease-positive pathogens. PCR analyses of chromosomal DNA implicated the tdh-independent, tlh-associated hemolysis in these strains. Both strains exhibited significant, diverse antibiotic profiles (p < 0.05). Turbidimetric and viable count assays revealed the pasteurization-resistant V. parahaemolyticus VHT1/VHT2 (62 °C, 8 h). These findings disclose the efficiency of Vibrio extremist recovery by the modified, two-step enrichment technique and improve knowledge of Vibrio biology essential to food safety reformation. FAU - Meza, Guadalupe AU - Meza G AD - Department of Biological and Environmental Sciences, University of West Alabama, Livingston, AL 35470, USA. AD - Clinical Laboratory, Huntsville Hospital, Huntsville, AL 35801, USA. FAU - Majrshi, Hussain AU - Majrshi H AUID- ORCID: 0000-0001-8870-4747 AD - Department of Biological and Environmental Sciences, University of West Alabama, Livingston, AL 35470, USA. FAU - Tiong, Hung King AU - Tiong HK AUID- ORCID: 0000-0002-7021-320X AD - Department of Biological and Environmental Sciences, University of West Alabama, Livingston, AL 35470, USA. LA - eng PT - Journal Article DEP - 20220307 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC8909376 OTO - NOTNLM OT - Vibrio parahaemolyticus OT - foodborne pathogen OT - heat-resistant OT - pasteurization OT - safety OT - seafood OT - spore OT - viable-but-non-culturable (VBNC) OT - vibriosis COIS- The authors have no known conflict of interest to disclose. EDAT- 2022/03/11 06:00 MHDA- 2022/03/11 06:01 PMCR- 2022/03/07 CRDT- 2022/03/10 15:24 PHST- 2022/01/21 00:00 [received] PHST- 2022/03/01 00:00 [revised] PHST- 2022/03/04 00:00 [accepted] PHST- 2022/03/10 15:24 [entrez] PHST- 2022/03/11 06:00 [pubmed] PHST- 2022/03/11 06:01 [medline] PHST- 2022/03/07 00:00 [pmc-release] AID - foods11050764 [pii] AID - foods-11-00764 [pii] AID - 10.3390/foods11050764 [doi] PST - epublish SO - Foods. 2022 Mar 7;11(5):764. doi: 10.3390/foods11050764. PMID- 37514929 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240930 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 23 IP - 14 DP - 2023 Jul 24 TI - Advancements in Triboelectric Nanogenerators (TENGs) for Intelligent Transportation Infrastructure: Enhancing Bridges, Highways, and Tunnels. LID - 10.3390/s23146634 [doi] LID - 6634 AB - The development of triboelectric nanogenerators (TENGs) over time has resulted in considerable improvements to the efficiency, effectiveness, and sensitivity of self-powered sensing. Triboelectric nanogenerators have low restriction and high sensitivity while also having high efficiency. The vast majority of previous research has found that accidents on the road can be attributed to road conditions. For instance, extreme weather conditions, such as heavy winds or rain, can reduce the safety of the roads, while excessive temperatures might make it unpleasant to be behind the wheel. Air pollution also has a negative impact on visibility while driving. As a result, sensing road surroundings is the most important technical system that is used to evaluate a vehicle and make decisions. This paper discusses both monitoring driving behavior and self-powered sensors influenced by triboelectric nanogenerators (TENGs). It also considers energy harvesting and sustainability in smart road environments such as bridges, tunnels, and highways. Furthermore, the information gathered in this study can help readers enhance their knowledge concerning the advantages of employing these technologies for innovative uses of their powers. FAU - Rayegani, Arash AU - Rayegani A AUID- ORCID: 0000-0001-7932-7038 AD - Centre for Infrastructure Engineering, Western Sydney University, Kingswood, NSW 2747, Australia. FAU - Matin Nazar, Ali AU - Matin Nazar A AUID- ORCID: 0000-0001-6303-3764 AD - Zhejiang University/University of Illinois at Urbana-Champaign Institute, Zhejiang University, Haining 314400, China. FAU - Rashidi, Maria AU - Rashidi M AUID- ORCID: 0000-0003-2847-3806 AD - Centre for Infrastructure Engineering, Western Sydney University, Kingswood, NSW 2747, Australia. LA - eng PT - Journal Article PT - Review DEP - 20230724 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC10384071 OTO - NOTNLM OT - energy harvesting OT - intelligent road environments OT - self-powered sensors OT - structural health monitoring OT - triboelectric nanogenerators (TENG) COIS- The authors declare no conflict of interest. EDAT- 2023/07/29 11:47 MHDA- 2023/07/29 11:48 PMCR- 2023/07/24 CRDT- 2023/07/29 01:44 PHST- 2023/05/22 00:00 [received] PHST- 2023/06/16 00:00 [revised] PHST- 2023/07/12 00:00 [accepted] PHST- 2023/07/29 11:48 [medline] PHST- 2023/07/29 11:47 [pubmed] PHST- 2023/07/29 01:44 [entrez] PHST- 2023/07/24 00:00 [pmc-release] AID - s23146634 [pii] AID - sensors-23-06634 [pii] AID - 10.3390/s23146634 [doi] PST - epublish SO - Sensors (Basel). 2023 Jul 24;23(14):6634. doi: 10.3390/s23146634. PMID- 35728797 OWN - NLM STAT- MEDLINE DCOM- 20221220 LR - 20230603 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 123 IP - 1 DP - 2023 Jan TI - Safety and Efficacy of Early Vitamin D Supplementation in Critically Ill Extremely Preterm Infants: An Ancillary Study of a Randomized Trial. PG - 87-94 LID - S2212-2672(22)00384-7 [pii] LID - 10.1016/j.jand.2022.06.012 [doi] AB - BACKGROUND: Despite substantial evidence that vitamin D deficiency is highly prevalent among infants born extremely preterm (≤28 weeks' of gestation), several consensus statements do not recommend vitamin D doses >400 IU/day for these infants. Safety remains a concern. OBJECTIVE: The study aim was to determine safety and efficacy profiles of enteral vitamin D in Black and White infants randomized to three different vitamin D doses soon after birth. DESIGN: Ancillary study of a masked randomized clinical trial. PARTICIPANTS/SETTING: Seventy-three infants born extremely preterm between 2012 and 2015 at a southern US academic neonatal unit (33' latitude) who had >90% compliance with the assigned intervention were included. INTERVENTION: Infants were randomized to receive placebo (placebo group), 200 IU/day vitamin D (200 IU group), or 800 IU/day vitamin D (800 IU group) during the first 28 days after birth. MAIN OUTCOME MEASURES: Safety outcomes included serum 25-hydroxy vitamin D (25[OH]D) and calcium concentrations. Efficacy outcomes included the predictive risk of bronchopulmonary dysplasia. STATISTICAL ANALYSIS: Per-protocol analysis using unadjusted, repeated-measures mixed models. RESULTS: Mean birth weight was 815 ± 199 g. Half were male and 56% were Black. Of 58 infants with 25(OH)D measurements at birth, 40 (69%) had vitamin D deficiency (<20 ng/mL). The mean difference in 25(OH)D in nanograms per milliliter between Postnatal Day 28 and Postnatal Day 1 was +9 in the placebo group, +23 in the 200 IU group, and +62 in the 800 IU group (P < 0.0001). The increase observed in 25(OH)D was more significant among Black infants. The predictive risk of severe bronchopulmonary dysplasia in the 200 IU and 800 IU groups was lower, but this difference did not reach statistical significance. No vitamin D or calcium toxicity was observed. CONCLUSIONS: A vitamin D dose of 800 IU/day safely corrected vitamin D deficiency by Postnatal Day 14. CI - Copyright © 2023 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Aristizabal, Natalia AU - Aristizabal N AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Holder, Mary Pat AU - Holder MP AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Durham, Leandra AU - Durham L AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Ashraf, Ambika P AU - Ashraf AP AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama. FAU - Taylor, Sarah AU - Taylor S AD - Department of Pediatrics, Yale University, New Haven, Connecticut. FAU - Salas, Ariel A AU - Salas AA AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: asalas@uab.edu. LA - eng SI - ClinicalTrials.gov/NCT01600430 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural DEP - 20220618 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 RN - SY7Q814VUP (Calcium) RN - 0 (Vitamins) RN - 1C6V77QF41 (Cholecalciferol) SB - IM MH - Infant MH - Infant, Newborn MH - Male MH - Humans MH - Female MH - Infant, Extremely Premature MH - *Bronchopulmonary Dysplasia/prevention & control MH - Critical Illness MH - Calcium MH - Dietary Supplements MH - Vitamins MH - *Vitamin D Deficiency/drug therapy MH - Cholecalciferol/therapeutic use MH - Double-Blind Method OTO - NOTNLM OT - Cholecalciferol OT - Chronic lung disease OT - Neonates OT - Premature newborn OT - Racial disparities EDAT- 2022/06/22 06:00 MHDA- 2022/12/21 06:00 CRDT- 2022/06/21 19:27 PHST- 2022/01/31 00:00 [received] PHST- 2022/06/14 00:00 [revised] PHST- 2022/06/15 00:00 [accepted] PHST- 2022/06/22 06:00 [pubmed] PHST- 2022/12/21 06:00 [medline] PHST- 2022/06/21 19:27 [entrez] AID - S2212-2672(22)00384-7 [pii] AID - 10.1016/j.jand.2022.06.012 [doi] PST - ppublish SO - J Acad Nutr Diet. 2023 Jan;123(1):87-94. doi: 10.1016/j.jand.2022.06.012. Epub 2022 Jun 18. PMID- 23706833 OWN - NLM STAT- MEDLINE DCOM- 20140707 LR - 20131126 IS - 1527-3296 (Electronic) IS - 0196-6553 (Linking) VI - 41 IP - 12 DP - 2013 Dec TI - Mucocutaneous blood contact: blood release behavior of safety peripheral intravenous catheters. PG - 1214-7 LID - S0196-6553(13)00293-9 [pii] LID - 10.1016/j.ajic.2013.02.015 [doi] AB - BACKGROUND: Protection against needlestick injuries has significantly improved in recent years thanks to so-called "safety devices." However, a potential drawback occasionally reported by users is a risk of blood splashing. If this blood comes in contact with the mucous membranes, it could lead to an infection. METHODS: Five safety peripheral intravenous catheter brands were examined in a laboratory test. To simulate the extreme situations, which may arise through human use, the introducer needle was withdrawn from the catheter at 2 different angles whereby an industrial robot was used to simulate the sequence of this movement. Each brand was tested 30 times. The experiment was carried out using radioactively labeled human whole blood. The measurements for the transmitted volume of blood was taken both from an artificial head and from a surface measuring 18.5 cm by 26.5 cm at a height of 30 cm above the catheter; scintigraphy was used to take the measurements. RESULTS: The volume of blood droplets potentially splashing into the mucous membranes was in the range of 1 nL. CONCLUSION: For normal virus concentrations in the blood of sick patients, this dose is too small to cause hepatitis C and HIV. CI - Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved. FAU - Wittmann, Andreas AU - Wittmann A AD - Bergische Universität Wuppertal, Department of Safety Engineering, Wuppertal, Germany. Electronic address: andwitt@uni-wuppertal.de. FAU - Köver, Jan AU - Köver J FAU - Kralj, Nenad AU - Kralj N FAU - Gasthaus, Klaus AU - Gasthaus K FAU - Tosch, Marco AU - Tosch M FAU - Hofmann, Friedrich AU - Hofmann F LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130521 PL - United States TA - Am J Infect Control JT - American journal of infection control JID - 8004854 SB - IM MH - *Blood MH - Catheterization, Peripheral/*instrumentation/*methods MH - *Catheters MH - *Disease Transmission, Infectious MH - Humans MH - *Occupational Exposure MH - *Protective Devices MH - Risk Assessment OTO - NOTNLM OT - Blood splatters OT - Risk of infection OT - Safety devices EDAT- 2013/05/28 06:00 MHDA- 2014/07/08 06:00 CRDT- 2013/05/28 06:00 PHST- 2012/12/20 00:00 [received] PHST- 2013/02/13 00:00 [revised] PHST- 2013/02/13 00:00 [accepted] PHST- 2013/05/28 06:00 [entrez] PHST- 2013/05/28 06:00 [pubmed] PHST- 2014/07/08 06:00 [medline] AID - S0196-6553(13)00293-9 [pii] AID - 10.1016/j.ajic.2013.02.015 [doi] PST - ppublish SO - Am J Infect Control. 2013 Dec;41(12):1214-7. doi: 10.1016/j.ajic.2013.02.015. Epub 2013 May 21. PMID- 38926355 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240629 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 15 IP - 1 DP - 2024 Jun 26 TI - Difluoroester solvent toward fast-rate anion-intercalation lithium metal batteries under extreme conditions. PG - 5408 LID - 10.1038/s41467-024-49795-9 [doi] LID - 5408 AB - Anion-intercalation lithium metal batteries (AILMBs) are appealing due to their low cost and fast intercalation/de-intercalation kinetics of graphite cathodes. However, the safety and cycliability of existing AILMBs are constrained by the scarcity of compatible electrolytes. Herein, we showcase that a difluoroester can be applied as electrolyte solvent to realize high-performance AILMBs, which not only endows high oxidation resistance, but also efficiently tunes the solvation shell to enable highly reversible and kinetically fast cathode reaction beyond the trifluoro counterpart. The difluoroester-based electrolyte demonstrates nonflammability, high ionic conductivity, and electrochemical stability, along with excellent electrode compatibility. The Li| |graphite AILMBs reach a high durability of 10000 cycles with only a 0.00128% capacity loss per cycle under fast-cycling of 1 A g(-1), and retain ~63% of room-temperature capacity when discharging at -65 °C, meanwhile supply stable power output under deformation and overcharge conditions. The electrolyte design paves a promising path toward fast-rate, low-temperature, durable, and safe AILMBs. CI - © 2024. The Author(s). FAU - Wang, Yao AU - Wang Y AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Dong, Shuyu AU - Dong S AD - School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, 999077, China. FAU - Gao, Yifu AU - Gao Y AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Lee, Pui-Kit AU - Lee PK AD - School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, 999077, China. FAU - Tian, Yao AU - Tian Y AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Meng, Yuefeng AU - Meng Y AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Hu, Xia AU - Hu X AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Zhao, Xin AU - Zhao X AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Li, Baohua AU - Li B AUID- ORCID: 0000-0002-4876-2659 AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. FAU - Zhou, Dong AU - Zhou D AUID- ORCID: 0000-0002-2578-7124 AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. zhou.d@sz.tsinghua.edu.cn. FAU - Kang, Feiyu AU - Kang F AD - Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China. fykang@tsinghua.edu.cn. LA - eng PT - Journal Article DEP - 20240626 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 SB - IM PMC - PMC11208432 COIS- The authors declare no competing interests. EDAT- 2024/06/27 00:42 MHDA- 2024/06/27 00:43 PMCR- 2024/06/26 CRDT- 2024/06/26 23:24 PHST- 2024/01/12 00:00 [received] PHST- 2024/06/13 00:00 [accepted] PHST- 2024/06/27 00:43 [medline] PHST- 2024/06/27 00:42 [pubmed] PHST- 2024/06/26 23:24 [entrez] PHST- 2024/06/26 00:00 [pmc-release] AID - 10.1038/s41467-024-49795-9 [pii] AID - 49795 [pii] AID - 10.1038/s41467-024-49795-9 [doi] PST - epublish SO - Nat Commun. 2024 Jun 26;15(1):5408. doi: 10.1038/s41467-024-49795-9. PMID- 37622170 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230906 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 15 IP - 35 DP - 2023 Sep 6 TI - Hazardous Gases-Responsive Photonic Crystals Cryogenic Sensors Based on Antifreezing and Water Retention Hydrogels. PG - 42046-42055 LID - 10.1021/acsami.3c06443 [doi] AB - Nowadays, the sensing of hazardous gases is urgent for the consideration of public safety and human health, especially in extreme conditions of low temperatures. In this study, a photonic crystals (PhCs) sensor with water retention and antifreezing properties was developed and applied to visual hazardous gases sensing at low temperature, passively. The sensor was prepared by dip-coating with poly(methyl methacrylate) (PMMA) colloidal microspheres followed by embedding in k-carrageenan/polyacrylamide-ethylene glycol (k-CA/PAM-EG) hydrogel. The sensor responded to hazardous gases, including ammonia, toluene, xylene, acetone, methanol, ethanol, and 1-propanol, with a change in the reflection wavelength and visible structural color. At room temperature, the reflection wavelength of the sensor blue-shifted 49 nm in ammonia, and the structural color changed from red to yellow. For low temperatures, the sensor showed great water retention and antifreezing properties even at -57 °C due to the double network. The sensor still had a great response to hazardous gases after freezing at -20 °C for 12 h and testing at 0 °C, and the obtained results were similar to those at room temperature. Based on this excellent stability and visual sensing at low temperature, the sensor demonstrates the potential for detection of hazardous vapors in extreme environments. FAU - Zhao, Jiang AU - Zhao J AD - School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Cai, Xiaolu AU - Cai X AD - School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Zhang, Xiaojing AU - Zhang X AD - School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. AD - Sinosteel Luoyang Institute of Refractories Research Co., Ltd., Luoyang, Henan Province 471039, China. FAU - Zhang, Jiaojiao AU - Zhang J AD - School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Fan, Jing AU - Fan J AD - School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Ma, Feng AU - Ma F AD - School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Zhu, Wei AU - Zhu W AD - School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Jia, Xiyu AU - Jia X AD - School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Wang, Shushan AU - Wang S AD - School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. FAU - Meng, Zihui AU - Meng Z AUID- ORCID: 0000-0002-2751-0057 AD - School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China. AD - Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314000, China. LA - eng PT - Journal Article DEP - 20230825 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - antifreezing OT - hazardous vapors OT - photonic crystals OT - visual detection OT - water retention EDAT- 2023/08/25 06:43 MHDA- 2023/08/25 06:44 CRDT- 2023/08/25 04:00 PHST- 2023/08/25 06:44 [medline] PHST- 2023/08/25 06:43 [pubmed] PHST- 2023/08/25 04:00 [entrez] AID - 10.1021/acsami.3c06443 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2023 Sep 6;15(35):42046-42055. doi: 10.1021/acsami.3c06443. Epub 2023 Aug 25. PMID- 29923468 OWN - NLM STAT- MEDLINE DCOM- 20181120 LR - 20181120 IS - 1469-7629 (Electronic) IS - 0022-0299 (Linking) VI - 85 IP - 3 DP - 2018 Aug TI - Technological attempts at producing cheese from donkey milk. PG - 327-330 LID - 10.1017/S0022029918000420 [doi] AB - The work described in this Research Communication addressed the hypothesis that it is possible to produce cheese from donkey milk by appropriate adjusting of the cheesemaking parameters. A series of coagulation trials were performed on donkey milk, alone or fortified with goat milk (85/15 and 70/30, v/v), using calf rennet under different technological conditions. The parameters that changed were pH and concentration of soluble calcium, amount of rennet added and temperature of coagulation. Donkey milk gave rise to sufficiently firm curd only at 'extreme' technological conditions and, as expected, addition of goat milk improved coagulation. A cheesemaking protocol was developed for producing fresh cheese prototypes, which were checked for microbiological safety, chemical composition and sensory characteristics. Pure donkey milk gave 5·9% yield, cheese having 6·12 pH, 32·4% dry matter, 2·1% fat and 18·5% protein. The electrophoretic analysis ascertained that β-casein was the most abundant compound in donkey cheese, but whey proteins were also present in non-negligible amounts. Finally, the sensory evaluation demonstrated that all cheeses were acceptable and provided detailed description of their flavour characteristics. FAU - Faccia, Michele AU - Faccia M AD - Department of Soil,Plant and Food Sciences,University of Bari,Bari,Italy. FAU - Gambacorta, Giuseppe AU - Gambacorta G AD - Department of Soil,Plant and Food Sciences,University of Bari,Bari,Italy. FAU - Martemucci, Giovanni AU - Martemucci G AD - Department of Agro-Environmental and Territorial Sciences,University of Bari,Bari,Italy. FAU - Natrella, Giuseppe AU - Natrella G AD - Department of Soil,Plant and Food Sciences,University of Bari,Bari,Italy. FAU - D'Alessandro, Angela G AU - D'Alessandro AG AD - Department of Agro-Environmental and Territorial Sciences,University of Bari,Bari,Italy. LA - eng PT - Journal Article DEP - 20180620 PL - England TA - J Dairy Res JT - The Journal of dairy research JID - 2985125R RN - 0 (Caseins) RN - 0 (Fats) RN - 0 (Milk Proteins) RN - 0 (Whey Proteins) SB - IM MH - Animals MH - Caseins/analysis MH - *Cheese/analysis/microbiology MH - Chemical Phenomena MH - *Equidae MH - Fats/analysis MH - Female MH - Food Handling/*methods MH - Hydrogen-Ion Concentration MH - *Milk/chemistry MH - Milk Proteins/analysis MH - Sensation MH - Whey Proteins/analysis OTO - NOTNLM OT - Donkey milk OT - cheesemaking OT - chemical characterization OT - sensory evaluation EDAT- 2018/06/21 06:00 MHDA- 2018/11/21 06:00 CRDT- 2018/06/21 06:00 PHST- 2018/06/21 06:00 [pubmed] PHST- 2018/11/21 06:00 [medline] PHST- 2018/06/21 06:00 [entrez] AID - S0022029918000420 [pii] AID - 10.1017/S0022029918000420 [doi] PST - ppublish SO - J Dairy Res. 2018 Aug;85(3):327-330. doi: 10.1017/S0022029918000420. Epub 2018 Jun 20. PMID- 29205995 OWN - NLM STAT- MEDLINE DCOM- 20180813 LR - 20191210 IS - 1120-9763 (Print) IS - 1120-9763 (Linking) VI - 41 IP - 5-6 (Suppl 2) DP - 2017 Sep-Dec TI - Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data. PG - 1-128 LID - 10.19191/EP17.5-6S2.P001.100 [doi] AB - BACKGROUND Improving quality and effectiveness of healthcare is one of the priorities of health policies. Hospital or physician volume represents a measurable variable with an impact on effectiveness of healthcare. An Italian law calls for the definition of «qualitative, structural, technological, and quantitative standards of hospital care». There is a need for an evaluation of the available scientific evidence in order to identify qualitative, structural, technological, and quantitative standards of hospital care, including the volume of care above or below which the public and private hospitals may be accredited (or not) to provide specific healthcare interventions. OBJECTIVES To identify conditions/interventions for which an association between volume and outcome has been investigated. To identify conditions/interventions for which an association between volume and outcome has been proved. To analyze the distribution of Italian health providers by volume of activity. To measure the association between volume of care and outcomes of the health providers of the Italian National Health Service (NHS). METHODS Systematic review An overview of systematic reviews was performed searching PubMed, EMBASE, and The Cochrane Library up to November 2016. Studies were evaluated by 2 researchers independently; quality assessment was performed using the AMSTAR checklist. For each health condition and outcome, if available, total number of studies, participants, high volume cut-off values, and metanalysis have been reported. According to the considered outcomes, health topics were classified into 3 groups: positive association: a positive association was demonstrated in the majority of studies/participants and/or a pooled measure (metanalysis) with positive results was reported; lack of association: both studies and/or metanalysis showed no association; no sufficient evidence of association: both results of single studies and metanalysis do not allow to draw firm conclusions on the association between volume and outcome. Analysis of the distribution of Italian hospitals by volume of activity and the association between volume of activity and outcomes: the Italian National Outcome evaluation Programme 2016 The analyses were performed using the Hospital Information System and the National Tax Register (year 2015). For each condition, the number of hospitals by volume of activity was calculated. Hospitals with a volume lower than 3-5 cases/year were excluded. For conditions with more than 1,500 cases/year and frequency of outcome ≥1%, the association between volume of care and outcome was analyzed estimating risk-adjusted outcomes. RESULTS Bibliographic searches identified 80 reviews, evaluating 48 different clinical areas. The main outcome considered was intrahospital/30-day mortality. The other outcomes vary depending on the type of condition or intervention in study. The relationship between hospital volume and outcomes was considered in 47 out of 48 conditions: 34 conditions showed evidence of a positive association; • 14 conditions consider cancer surgery for bladder, breast, colon, rectum, colon rectum, oesophagus, kidney, liver, lung, ovaries, pancreas, prostate, stomach, head and neck; • 11 conditions consider cardiocerebrovascular area: nonruptured and ruptured abdominal aortic aneurysm, acute myocardial infarction, brain aneurysm, carotid endarterectomy, coronary angioplasty, coronary artery bypass, paediatric heart surgery, revascularization of lower limbs, stroke, subarachnoid haemorrhage; • 2 conditions consider orthopaedic area: knee arthroplasty, hip fracture; • 7 conditions consider other areas: AIDS, bariatric surgery, cholecystectomy, intensive care unit, neonatal intensive care unit, sepsis, and traumas; for 3 conditions, no association was demonstrated: hip arthroplasty, dialysis, and thyroidectomy. for the remaining 10 conditions, the available evidence does not allow to draw firm conclusions about the association between hospital volume and considered outcomes: surgery for testicular cancer and intracranial tumours, paediatric oncology, aortofemoral bypass, cardiac catheterization, appendectomy, colectomy, inguinal hernia, respiratory failure, and hysterectomy. The relationship between volume of clinician/surgeon and outcomes was assessed only through the literature re view; to date, it is not possible to analyze this association for Italian health provider hospitals, since information on the clinician/surgeon on the hospital discharge chart is missing. The literature found a positive association for 21 conditions: 9 consider surgery for cancer: bladder, breast, colon, colon rectum, pancreas, prostate, rectum, stomach, and head and neck; 5 consider the cardiocerebrovascular area: ruptured and nonruptured abdominal aortic aneurysm, carotid endarterectomy, paediatric heart surgery, and revascularization of the lower limbs; 2 consider the orthopaedic area: knee and hip arthroplasty; 5 consider other areas: AIDS, bariatric surgery, hysterectomy, intensive care unit, and thyroidectomy. The analysis of the distribution of Italian hospitals concerned the 34 conditions for which the systematic review has shown a positive volume-outcome association. For the following, it was possible to conduct the analysis of the association using national data: unruptured abdominal aortic aneurysm, coronary angioplasty, hip arthroplasty, knee arthroplasty, coronary artery bypass, cancer surgery (colon, liver, breast, pancreas, lung, prostate, kidney, and stomach), laparoscopic cholecystectomy, hip fracture, stroke, acute myocardial infarction. For these conditions, the association between volume and outcome of care was observed. For laparoscopic cholecystectomy and surgery of the breast and stomach cancer, the association between the volume of the discharge (o dismissal) operating unit and the outcome was analyzed. The outcomes differ depending on the condition studied. The shape of the relationship is variable among different conditions, with heterogeneous slope of the curves. DISCUSSION For many conditions, the overview of systematic reviews has shown a strong evidence of association between higher volumes and better outcomes. The quality of the available reviews can be considered good for the consistency of the results between the studies and for the strength of the association; however, this does not mean that the included studies are of good quality. Analyzing national data, potential confounders, including age and comorbidities, have been considered. The systematic review of the literature does not permit to identify predefined volume thresholds. The analysis of national data shows a strong improvement in outcomes in the first part of the curve (from very low to higher volumes) for most conditions. In some cases, the improvement in outcomes remains gradual or constant with the increasing volume of care; in other, the analysis could allow the identification of threshold values beyond which the outcome does not further improve. However, a good knowledge of the relationship between effectiveness of treatments and costs, the geographical distribution and the accessibility to healthcare services are necessary to choose the minimum volumes of care, under which specific health procedures could not been provided in the NHS. Some potential biases due to the use of information systems data should also be considered. The different way of coding among hospitals could lead to a different selection of cases for some conditions. Regarding the definition of the exposure (volume of care), a possible bias could result from misclassification of health providers with high volume of activity. Performing the intervention in different departments/ units of the same hospital would result in an overestimation of the volume of care measured for hospital rather than for department/unit. For the conditions with a further fragmentation within the same structure, the association between volumes of discharge department and outcomes has also been evaluated. In this case, the two curves were different. The limit is to attribute the outcome to the discharge unit, which in case of surgery may not be the intervention unit. A similar bias could occur if the main determinant of the outcome of treatment was the caseload of each surgeon. The results of the analysis may be biased when different operators in the same hospital/unit carried out the same procedure. In any case, the observed association between volumes and outcome is very strong, and it is unlikely to be attributable to biases of the study design. Another aspect on which there is still little evidence is the interaction between volume of the hospital and of the surgeon. A MEDICARE study suggests that in some conditions, especially for specialized surgery, the effect of the surgeon's volume of activity is different depending on the structure volume, whereas it would not differ for some less specialized surgery conditions. The data here presented still show extremely fragmented volumes of both clinical and surgical areas, with a predominance of very low volume structures. Health systems operate, by definition, in a context of limited resources, especially when the amount of resources to allocate to the health system is reduced. In such conditions, the rationalization of the organization of health services based on the volume of care may make resources available to improve the effectiveness of interventions. The identification and certification of services and providers with high volume of activity can help to reduce differences in the access to non-effective procedures. To produce additional evidence to guide the reorganization of the national healthcare system, it will be necessary to design further primary studies to evaluate the effectiveness and safety of policies aimed at concentrating interventions in structures with high volumes of activity. FAU - Amato, Laura AU - Amato L AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Fusco, Danilo AU - Fusco D AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Acampora, Anna AU - Acampora A AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Bontempi, Katia AU - Bontempi K AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Rosa, Alessandro Cesare AU - Rosa AC AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Colais, Paola AU - Colais P AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Cruciani, Fabio AU - Cruciani F AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. f.cruciani@deplazio.it. FAU - D'Ovidio, Mariangela AU - D'Ovidio M AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Mataloni, Francesca AU - Mataloni F AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Minozzi, Silvia AU - Minozzi S AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Mitrova, Zuzana AU - Mitrova Z AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Pinnarelli, Luigi AU - Pinnarelli L AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Saulle, Rosella AU - Saulle R AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Soldati, Salvatore AU - Soldati S AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Sorge, Chiara AU - Sorge C AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Vecchi, Simona AU - Vecchi S AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Ventura, Martina AU - Ventura M AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. FAU - Davoli, Marina AU - Davoli M AD - Dipartimento di epidemiologia del Servizio sanitario regionale, ASL Roma1, Regione Lazio, Roma. LA - eng LA - ita PT - Journal Article TT - Volumi di attività ed esiti delle cure: prove scientifiche in letteratura ed evidenze empiriche in Italia. PL - Italy TA - Epidemiol Prev JT - Epidemiologia e prevenzione JID - 8902507 SB - IM EIN - Epidemiol Prev. 2018 May-Aug;42(3-4):199. doi: 10.19191/EP18.3-4.ERRATA.082. PMID: 30066536 MH - Cardiovascular Diseases/epidemiology/therapy MH - Causality MH - Critical Care MH - Hospital Departments/statistics & numerical data MH - Hospitals/*statistics & numerical data/supply & distribution MH - Hospitals, High-Volume/statistics & numerical data/supply & distribution MH - Humans MH - Infectious Disease Medicine MH - Italy/epidemiology MH - Neoplasms/epidemiology/therapy MH - Orthopedics MH - *Outcome Assessment, Health Care MH - Review Literature as Topic MH - Surgeons/statistics & numerical data EDAT- 2017/12/06 06:00 MHDA- 2018/08/14 06:00 CRDT- 2017/12/06 06:00 PHST- 2017/12/06 06:00 [entrez] PHST- 2017/12/06 06:00 [pubmed] PHST- 2018/08/14 06:00 [medline] AID - 3928 [pii] AID - 10.19191/EP17.5-6S2.P001.100 [doi] PST - ppublish SO - Epidemiol Prev. 2017 Sep-Dec;41(5-6 (Suppl 2)):1-128. doi: 10.19191/EP17.5-6S2.P001.100. PMID- 17468231 OWN - NLM STAT- MEDLINE DCOM- 20071227 LR - 20161124 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 1112 DP - 2007 Sep TI - Epidermolysis bullosa: a genetic disease of altered cell adhesion and wound healing, and the possible clinical utility of topically applied thymosin beta4. PG - 396-406 AB - Inherited epidermolysis bullosa (EB), having an overall incidence of only about 19 in every 1 million live births, encompasses many phenotypically and genotypically distinct diseases characterized by the presence of recurrent blisters, mechanical fragility of the skin and other epithelial structures (most notably the cornea and gastrointestinal tract), and scar formation. Each disease is the result of mutations within any of 10 specific structural proteins (keratins, laminins, collagens, integrins) within the basilar keratinocyte or the skin basement membrane zone. Two of the more severe subtypes, junctional and dystrophic EB, often involve many extracutaneous tissues. If severe, these conditions may be life threatening. Recent studies in wounds that had been artificially induced on normal skin, both in rodents and in human volunteers, have suggested that thymosin beta4 may be effective in promoting epithelial migration across the wounds. A randomized double-blind clinical trial has been recently organized to determine whether this novel biologic agent may be beneficial in promoting wound healing in patients with junctional and dystrophic EB. To do so, a solitary noninfected cutaneous wound of standardized size will be treated topically on a daily basis with either one of three concentrations of thymosin beta4 or a placebo control. Serial wound healing will be quantitated by computerized digital-imaging technique. At the same time, the occurrence of adverse effects will be sought, so as to confirm the safety of thymosin beta4 when applied to EB skin, both in children and in adults. Although as yet unproven, topically applied thymosin beta4 may prove to be an extremely important addition to the overall management of patients with this potentially devastating disease. FAU - Fine, Jo-David AU - Fine JD AD - Department of Medicine (Dermatology), Vanderbilt University School of Medicine, Nashville, TN 37203, USA. Jo-David.Fine@vanderbilt.edu LA - eng PT - Journal Article DEP - 20070427 PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 549LM7U24W (thymosin beta(4)) RN - 61512-21-8 (Thymosin) SB - IM MH - Administration, Topical MH - Cell Adhesion/drug effects MH - Epidermolysis Bullosa/*drug therapy/epidemiology/genetics MH - Thymosin/*administration & dosage/*therapeutic use MH - Wound Healing/drug effects EDAT- 2007/05/01 09:00 MHDA- 2007/12/28 09:00 CRDT- 2007/05/01 09:00 PHST- 2007/05/01 09:00 [pubmed] PHST- 2007/12/28 09:00 [medline] PHST- 2007/05/01 09:00 [entrez] AID - annals.1415.017 [pii] AID - 10.1196/annals.1415.017 [doi] PST - ppublish SO - Ann N Y Acad Sci. 2007 Sep;1112:396-406. doi: 10.1196/annals.1415.017. Epub 2007 Apr 27. PMID- 10687910 OWN - NLM STAT- MEDLINE DCOM- 20000225 LR - 20131121 IS - 0266-4356 (Print) IS - 0266-4356 (Linking) VI - 37 IP - 6 DP - 1999 Dec TI - Comparison of two techniques of patient-controlled sedation with midazolam. PG - 472-6 AB - OBJECTIVE: To compare patient-controlled sedation with 1-mg increments of midazolam at 1-min intervals with 0.1-mg increments of midazolam without a lock-out interval. DESIGN: Randomized cross over study. SUBJECTS: 32 patients aged 17-35 years having third molars removed. RESULTS: Doses of midazolam obtained, degree of sedation and operating conditions were similar in the two groups. The demands far exceeded the increments actually received by patients obtaining 0.1-mg increments. Some were extremely sedated with both techniques. CONCLUSIONS: In this age group, there were no significant advantages or disadvantages of one technique over the other. Patients obtained the degree of sedation they required to undergo the operation by pressing the button independently of the dose or incremental interval. So-called 'true' patient-controlled sedation is a misnomer. The cut-off interval proved to be an extremely important safety feature. FAU - Rodrigo, M R AU - Rodrigo MR AD - Faculty of Dentistry, University of Hong Kong, Hong Kong, PR China. FAU - Fung, S C AU - Fung SC LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - Scotland TA - Br J Oral Maxillofac Surg JT - The British journal of oral & maxillofacial surgery JID - 8405235 RN - 0 (Hypnotics and Sedatives) RN - R60L0SM5BC (Midazolam) SB - IM MH - Adolescent MH - Adult MH - *Analgesia, Patient-Controlled MH - Anesthesia, Dental/*methods MH - Conscious Sedation/methods MH - Cross-Over Studies MH - Female MH - Humans MH - Hypnotics and Sedatives/*administration & dosage MH - Male MH - Midazolam/*administration & dosage MH - Molar, Third/*surgery MH - Patient Satisfaction MH - Tooth Extraction EDAT- 2000/02/25 09:00 MHDA- 2000/03/04 09:00 CRDT- 2000/02/25 09:00 PHST- 2000/02/25 09:00 [pubmed] PHST- 2000/03/04 09:00 [medline] PHST- 2000/02/25 09:00 [entrez] AID - S0266-4356(99)90118-3 [pii] AID - 10.1054/bjom.1999.0118 [doi] PST - ppublish SO - Br J Oral Maxillofac Surg. 1999 Dec;37(6):472-6. doi: 10.1054/bjom.1999.0118. PMID- 36002982 OWN - NLM STAT- MEDLINE DCOM- 20221129 LR - 20221129 IS - 2165-0969 (Electronic) IS - 2165-0799 (Linking) VI - 70 IP - 12 DP - 2022 Dec TI - Fluid Intake and Hydration Status Among North Carolina Farmworkers: A Mixed Methods Study. PG - 532-541 LID - 10.1177/21650799221117273 [doi] AB - BACKGROUND: Agricultural workers are disproportionately at risk for heat-related morbidity and mortality. The purpose of this study was to explore how sociocultural and occupational factors, and environmental heat stress influenced fluid intake and hydration status among Latino farmworkers working in eastern North Carolina. METHODS: A community-informed, mixed methods research study was conducted in partnership with staff at a federally qualified health center. In summer 2020, we recruited Latino farmworkers at migrant camps. Twenty-eight male, migrant farmworkers participated in focus group discussions and 30 completed surveys and provided urine specimens. Wet bulb globe temperatures were measured in fields where workers labored. Content analysis and parametric analyses were performed. Data integration was completed using a meta-matrix. RESULTS: Prior to work, 46.7% of farmworkers' urine specific gravity measurements indicated dehydration, which increased to 100% after work. The farmworkers spent between 2 and 7.5 hours of their day working in conditions above the recommended limits for workplace heat exposure. Farmworkers described exposure to extreme heat and inconsistent occupational policy compliance. Farmworkers expressed the opportunity to drink water but accessibility and poor water quality limited hydration. The integrated data supported congruent findings of extreme heat, few work breaks, and substandard housing. CONCLUSION/APPLICATION TO PRACTICE: Farmworkers are dehydrated at work, placing them at higher risk for heat-related illness (HRI). By engaging with agricultural stakeholders, occupational health nurses can combine efforts and advocate for effective health and safety work policies to reduce HRIs and deaths among farmworkers. Legislation stipulating cooling and hydration practices would support safer work environments. FAU - Mizelle, Elizabeth AU - Mizelle E AUID- ORCID: 0000-0002-5709-3047 AD - East Carolina University. FAU - Larson, Kim L AU - Larson KL AD - East Carolina University. FAU - Bolin, Linda P AU - Bolin LP AD - East Carolina University. FAU - Kearney, Gregory D AU - Kearney GD AD - East Carolina University. LA - eng PT - Journal Article DEP - 20220824 PL - United States TA - Workplace Health Saf JT - Workplace health & safety JID - 101575677 MH - Male MH - Humans MH - Farmers MH - North Carolina MH - *Occupational Exposure MH - *Heat Stress Disorders/prevention & control MH - *Transients and Migrants MH - Agriculture OTO - NOTNLM OT - farmworkers OT - fluid intake OT - heat-related illness OT - hydration status EDAT- 2022/08/26 06:00 MHDA- 2022/11/30 06:00 CRDT- 2022/08/25 01:03 PHST- 2022/08/26 06:00 [pubmed] PHST- 2022/11/30 06:00 [medline] PHST- 2022/08/25 01:03 [entrez] AID - 10.1177/21650799221117273 [doi] PST - ppublish SO - Workplace Health Saf. 2022 Dec;70(12):532-541. doi: 10.1177/21650799221117273. Epub 2022 Aug 24. PMID- 25364733 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141103 LR - 20201001 IS - 2296-634X (Print) IS - 2296-634X (Electronic) IS - 2296-634X (Linking) VI - 2 DP - 2014 TI - Manufacturing blood ex vivo: a futuristic approach to deal with the supply and safety concerns. PG - 26 LID - 10.3389/fcell.2014.00026 [doi] LID - 26 AB - Blood transfusions are routinely done in every medical regimen and a worldwide established collection, processing/storage centers provide their services for the same. There have been extreme global demands for both raising the current collections and supply of safe/adequate blood due to increasingly demanding population. With, various risks remain associated with the donor derived blood, and a number of post collection blood screening and processing methods put extreme constraints on supply system especially in the underdeveloped countries. A logistic approach to manufacture erythrocytes ex-vivo by using modern tissue culture techniques have surfaced in the past few years. There are several reports showing the possibilities of RBCs (and even platelets/neutrophils) expansion under tightly regulated conditions. In fact, ex vivo synthesis of the few units of clinical grade RBCs from a single dose of starting material such as umbilical cord blood (CB) has been well established. Similarly, many different sources are also being explored for the same purpose, such as embryonic stem cells, induced pluripotent stem cells. However, the major concerns remain elusive before the manufacture and clinical use of different blood components may be used to successfully replace the present system of donor derived blood transfusion. The most important factor shall include the large scale of RBCs production from each donated unit within a limited time period and cost of their production, both of these issues need to be handled carefully since many of the recipients among developing countries are unable to pay even for the freely available donor derived blood. Anyways, keeping these issues in mind, present article shall be focused on the possibilities of blood production and their use in the near future. FAU - Singh, Vimal K AU - Singh VK AD - Stem Cell Research Laboratory, Department of Biotechnology, Delhi Technological University Delhi, India. FAU - Saini, Abhishek AU - Saini A AD - Stem Cell Research Laboratory, Department of Biotechnology, Delhi Technological University Delhi, India. FAU - Tsuji, Kohichiro AU - Tsuji K AD - Departments of Pediatric Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo Hospital Tokyo, Japan. FAU - Sharma, P B AU - Sharma PB AD - Stem Cell Research Laboratory, Department of Biotechnology, Delhi Technological University Delhi, India. FAU - Chandra, Ramesh AU - Chandra R AD - Dr B. R. Ambedkar Center for Biomedical Research, University of Delhi Delhi, India. LA - eng PT - Journal Article PT - Review DEP - 20140611 PL - Switzerland TA - Front Cell Dev Biol JT - Frontiers in cell and developmental biology JID - 101630250 PMC - PMC4206981 OTO - NOTNLM OT - RBCs OT - ex-vivo erythrocytes OT - hematopoietic stem cells OT - induced pluripotent stem cells OT - manufacturing blood EDAT- 2014/11/05 06:00 MHDA- 2014/11/05 06:01 PMCR- 2014/01/01 CRDT- 2014/11/04 06:00 PHST- 2014/01/25 00:00 [received] PHST- 2014/05/26 00:00 [accepted] PHST- 2014/11/04 06:00 [entrez] PHST- 2014/11/05 06:00 [pubmed] PHST- 2014/11/05 06:01 [medline] PHST- 2014/01/01 00:00 [pmc-release] AID - 10.3389/fcell.2014.00026 [doi] PST - epublish SO - Front Cell Dev Biol. 2014 Jun 11;2:26. doi: 10.3389/fcell.2014.00026. eCollection 2014. PMID- 28036382 OWN - NLM STAT- MEDLINE DCOM- 20170710 LR - 20240327 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 12 DP - 2016 TI - Production of Secondary Metabolites in Extreme Environments: Food- and Airborne Wallemia spp. Produce Toxic Metabolites at Hypersaline Conditions. PG - e0169116 LID - 10.1371/journal.pone.0169116 [doi] LID - e0169116 AB - The food- and airborne fungal genus Wallemia comprises seven xerophilic and halophilic species: W. sebi, W. mellicola, W. canadensis, W. tropicalis, W. muriae, W. hederae and W. ichthyophaga. All listed species are adapted to low water activity and can contaminate food preserved with high amounts of salt or sugar. In relation to food safety, the effect of high salt and sugar concentrations on the production of secondary metabolites by this toxigenic fungus was investigated. The secondary metabolite profiles of 30 strains of the listed species were examined using general growth media, known to support the production of secondary metabolites, supplemented with different concentrations of NaCl, glucose and MgCl2. In more than two hundred extracts approximately one hundred different compounds were detected using high-performance liquid chromatography-diode array detection (HPLC-DAD). Although the genome data analysis of W. mellicola (previously W. sebi sensu lato) and W. ichthyophaga revealed a low number of secondary metabolites clusters, a substantial number of secondary metabolites were detected at different conditions. Machine learning analysis of the obtained dataset showed that NaCl has higher influence on the production of secondary metabolites than other tested solutes. Mass spectrometric analysis of selected extracts revealed that NaCl in the medium affects the production of some compounds with substantial biological activities (wallimidione, walleminol, walleminone, UCA 1064-A and UCA 1064-B). In particular an increase in NaCl concentration from 5% to 15% in the growth media increased the production of the toxic metabolites wallimidione, walleminol and walleminone. FAU - Jančič, Sašo AU - Jančič S AD - Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia. FAU - Frisvad, Jens C AU - Frisvad JC AD - Department of System Biology, Technical University of Denmark, Søltofts Plads, Building 221, Kgs. Lyngby, Denmark. FAU - Kocev, Dragi AU - Kocev D AD - Department of Knowledge Technologies, Jožef Stefan Institute, Jamova cesta 39, Ljubljana, Slovenia. FAU - Gostinčar, Cene AU - Gostinčar C AUID- ORCID: 0000-0002-0149-3674 AD - Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia. FAU - Džeroski, Sašo AU - Džeroski S AD - Department of Knowledge Technologies, Jožef Stefan Institute, Jamova cesta 39, Ljubljana, Slovenia. FAU - Gunde-Cimerman, Nina AU - Gunde-Cimerman N AD - Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, Ljubljana, Slovenia. AD - Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins (CIPKeBiP), Jamova 39, Ljubljana, Slovenia. LA - eng PT - Journal Article DEP - 20161230 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Azasteroids) RN - 0 (Cholestadienols) RN - 0 (Mycotoxins) RN - 0 (Sesquiterpenes) RN - 0 (walleminone) RN - 02F3473H9O (Magnesium Chloride) RN - 126039-09-6 (walleminol A) RN - 144773-49-9 (UCA 1064-B) RN - 451W47IQ8X (Sodium Chloride) RN - 50686-98-1 (A25822B) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Azasteroids/metabolism MH - Basidiomycota/classification/*genetics/*metabolism MH - Cholestadienols/metabolism MH - Chromatography, High Pressure Liquid MH - *Extreme Environments MH - Food Contamination MH - Food Microbiology MH - Glucose/metabolism MH - Magnesium Chloride/metabolism MH - Mycotoxins/*metabolism MH - Secondary Metabolism/*genetics/physiology MH - Sesquiterpenes/metabolism MH - Sodium Chloride/*metabolism PMC - PMC5201246 COIS- The authors have declared that no competing interests exist. EDAT- 2016/12/31 06:00 MHDA- 2017/07/14 06:00 PMCR- 2016/12/30 CRDT- 2016/12/31 06:00 PHST- 2016/07/11 00:00 [received] PHST- 2016/12/11 00:00 [accepted] PHST- 2016/12/31 06:00 [entrez] PHST- 2016/12/31 06:00 [pubmed] PHST- 2017/07/14 06:00 [medline] PHST- 2016/12/30 00:00 [pmc-release] AID - PONE-D-16-27589 [pii] AID - 10.1371/journal.pone.0169116 [doi] PST - epublish SO - PLoS One. 2016 Dec 30;11(12):e0169116. doi: 10.1371/journal.pone.0169116. eCollection 2016. PMID- 15108980 OWN - NLM STAT- MEDLINE DCOM- 20040507 LR - 20191210 IS - 0003-3022 (Print) IS - 0003-3022 (Linking) VI - 100 IP - 3 DP - 2004 Mar TI - Performance evaluation of two published closed-loop control systems using bispectral index monitoring: a simulation study. PG - 640-7 AB - BACKGROUND: Although automated closed-loop control systems may improve quality of care, their safety must be proved under extreme control conditions. This study describes a simulation methodology to test automated controllers and its application in a comparison of two published controllers for Bispectral Index (BIS)-guided propofol administration. METHODS: A patient simulator was developed to compare controllers. Using input scripts to dictate patient characteristics, target BIS values, and the time course of surgical events, the simulator continuously monitors the infusion pump under control and generates BIS values as a composite of modeled response to drug, perceived stimulation, and random noise. The simulator formats the output stream of BIS data as input to the controller under test to emulate the serial output of the actual BIS monitor. A published model-based controller and a classic proportional integral derivative controller were compared when using the BIS value as a controlled variable. Each controller was tested using a set of 10 virtual patients undergoing a fixed surgical profile that was repeated with BIS targets set at 30, 50, and 70. Controller performance was assessed using median (absolute) prediction error, divergence, wobble, and percentage time within BIS target range metrics. RESULTS: The median prediction error was significantly smaller for the proportional integral derivative controller than for the model-based controller. The median absolute prediction error was smaller for the model-based controller than for the proportional integral derivative controller for each BIS target, reaching statistical significance for targets 30 and 50. CONCLUSIONS: When simulating closed-loop control of BIS using propofol, the use of a patient-individualized, model-based adaptive closed-loop system with effect site control resulted in better control of BIS compared with a standard proportional integral derivative controller with plasma site control. Even under extreme conditions, the modeled-based controller exhibited no behavioral problems. FAU - Struys, Michel M R F AU - Struys MM AD - Department of Anesthesia, Ghent University Hospital, Gent, Belgium. michel.struys@ugent.be FAU - De Smet, Tom AU - De Smet T FAU - Greenwald, Scott AU - Greenwald S FAU - Absalom, Anthony R AU - Absalom AR FAU - Bingé, Servaas AU - Bingé S FAU - Mortier, Eric P AU - Mortier EP LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Anesthesiology JT - Anesthesiology JID - 1300217 SB - IM MH - Algorithms MH - *Anesthesia, Closed-Circuit MH - Computer Simulation MH - Electroencephalography/*drug effects MH - Models, Biological MH - Software EDAT- 2004/04/28 05:00 MHDA- 2004/05/08 05:00 CRDT- 2004/04/28 05:00 PHST- 2004/04/28 05:00 [pubmed] PHST- 2004/05/08 05:00 [medline] PHST- 2004/04/28 05:00 [entrez] AID - 10.1097/00000542-200403000-00026 [doi] PST - ppublish SO - Anesthesiology. 2004 Mar;100(3):640-7. doi: 10.1097/00000542-200403000-00026. PMID- 31815621 OWN - NLM STAT- MEDLINE DCOM- 20200915 LR - 20240723 IS - 1478-4491 (Electronic) IS - 1478-4491 (Linking) VI - 17 IP - 1 DP - 2019 Dec 9 TI - 'Everything was just getting worse and worse': deteriorating job quality as a driver of doctor emigration from Ireland. PG - 97 LID - 10.1186/s12960-019-0424-y [doi] LID - 97 AB - BACKGROUND: Medicine is a high-status, high-skill occupation which has traditionally provided access to good quality jobs and relatively high salaries. In Ireland, historic underfunding combined with austerity-related cutbacks has negatively impacted job quality to the extent that hospital medical jobs have begun to resemble extreme jobs. Extreme jobs combine components of a good quality job-high pay, high job control, challenging demands, with those of a low-quality job-long working hours, heavy workloads. Deteriorating job quality and the normalisation of extreme working is driving doctor emigration from Ireland and deterring return. METHODS: Semi-structured qualitative interviews were conducted with 40 Irish emigrant doctors in Australia who had emigrated from Ireland since 2008. Interviews were held in July-August 2018. RESULTS: Respondents reflected on their experiences of working in the Irish health system, describing hospital workplaces that were understaffed, overstretched and within which extreme working had become normalised, particularly in relation to long working hours, fast working pace, doing more with less and fighting a climate of negativity. Drawing on Hirschman's work on exit, voice and loyalty (1970), the authors consider doctor emigration as exit and present respondent experiences of voice prior to emigration. Only 14/40 respondent emigrant doctors intend to return to work in Ireland. DISCUSSION: The deterioration in medical job quality and the normalisation of extreme working is a key driver of doctor emigration from Ireland, and deterring return. Irish trained hospital doctors emigrate to access good quality jobs in Australia and are increasingly likely to remain abroad once they have secured them. To improve doctor retention, health systems and employers must mitigate a gainst the emergence of extreme work in healthcare. Employee voice (about working conditions, about patient safety, etc.) should be encouraged and used to inform health system improvement and to mitigate exit. FAU - Humphries, N AU - Humphries N AUID- ORCID: 0000-0003-2959-1652 AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. niamhhumphries@rcpi.ie. FAU - McDermott, A M AU - McDermott AM AD - Cardiff Business School, Cardiff University, Cardiff, UK. FAU - Conway, E AU - Conway E AD - Dublin City University Business School, Dublin City University, Dublin, Ireland. FAU - Byrne, J-P AU - Byrne JP AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. FAU - Prihodova, L AU - Prihodova L AD - Research Royal College of Physicians of Ireland, Dublin, Ireland. FAU - Costello, R AU - Costello R AD - Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Matthews, A AU - Matthews A AD - School of Nursing, Psychotherapy and Community Health, Dublin City University, Dublin, Ireland. LA - eng GR - Emerging Investigator Award (EIA-2017-022)./HRBI_/Health Research Board/Ireland PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191209 PL - England TA - Hum Resour Health JT - Human resources for health JID - 101170535 SB - IM MH - Adult MH - *Attitude of Health Personnel MH - Australia MH - Emigrants and Immigrants/*psychology/statistics & numerical data MH - Emigration and Immigration/statistics & numerical data MH - Female MH - Foreign Medical Graduates/*psychology/*statistics & numerical data MH - Humans MH - Interviews as Topic MH - Ireland/ethnology MH - *Job Satisfaction MH - Male MH - Physicians/psychology/statistics & numerical data MH - Professional Practice Location/*statistics & numerical data MH - Workload/psychology/statistics & numerical data MH - Young Adult PMC - PMC6902557 OTO - NOTNLM OT - Austerity OT - Extreme work OT - Job quality OT - Medicine OT - Migration OT - Qualitative COIS- The authors declare that they have no competing interests. EDAT- 2019/12/10 06:00 MHDA- 2020/09/17 06:00 PMCR- 2019/12/09 CRDT- 2019/12/10 06:00 PHST- 2019/07/10 00:00 [received] PHST- 2019/10/21 00:00 [accepted] PHST- 2019/12/10 06:00 [entrez] PHST- 2019/12/10 06:00 [pubmed] PHST- 2020/09/17 06:00 [medline] PHST- 2019/12/09 00:00 [pmc-release] AID - 10.1186/s12960-019-0424-y [pii] AID - 424 [pii] AID - 10.1186/s12960-019-0424-y [doi] PST - epublish SO - Hum Resour Health. 2019 Dec 9;17(1):97. doi: 10.1186/s12960-019-0424-y. PMID- 35937596 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220809 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 9 DP - 2022 TI - Endoscopic transorbital eyelid approach for the removal of an extraconal cavernous venous malformation: Case report. PG - 954530 LID - 10.3389/fsurg.2022.954530 [doi] LID - 954530 AB - Cavernous venous malformations (CVMs) are one of the most common benign primary orbital lesions in adults and the second most frequent cause of unilateral proptosis. Extraconal location is extremely rare, representing a favorable condition as compared to intraconal, as lesions at this level often adhere to orbital muscles and optic nerve. Herein, we report the case of a 50-year-old patient, who came to our attention because of progressive painless right axial proptosis. Magnetic resonance images were consistent with an extraconal CVM, occupying the superior temporal compartment of the orbit. Successful removal of the lesion was achieved through an endoscopic transorbital eyelid approach. The present case confirms the safety and efficacy of the endoscopic transorbital eyelid approach. CI - © 2022 Fabozzi, d'Avella, Burroni, Romano, Cavallo and Solari. FAU - Fabozzi, Gianluca Lorenzo AU - Fabozzi GL AD - Department of Neurosciences and Reproductive and Dental Sciences, Division of Neurosurgery, Federico II University of Naples, Naples, Italy. FAU - d'Avella, Elena AU - d'Avella E AD - Department of Neurosciences and Reproductive and Dental Sciences, Division of Neurosurgery, Federico II University of Naples, Naples, Italy. FAU - Burroni, Matias AU - Burroni M AD - Department of Neurosurgery, Hospital Pedro de Elizalde, Buenos Aires, Argentina. FAU - Romano, Antonio AU - Romano A AD - Department of Neurosciences and Reproductive and Dental Sciences, Division of Maxillofacial Surgery Unit, Federico II University of Naples, Naples, Italy. FAU - Cavallo, Luigi Maria AU - Cavallo LM AD - Department of Neurosciences and Reproductive and Dental Sciences, Division of Neurosurgery, Federico II University of Naples, Naples, Italy. FAU - Solari, Domenico AU - Solari D AD - Department of Neurosciences and Reproductive and Dental Sciences, Division of Neurosurgery, Federico II University of Naples, Naples, Italy. LA - eng PT - Case Reports PT - Journal Article DEP - 20220721 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC9349361 OTO - NOTNLM OT - cavernous venous malformation OT - endoscopic eyelid approach OT - extraconal OT - orbit OT - protosis COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/08/09 06:00 MHDA- 2022/08/09 06:01 PMCR- 2022/07/21 CRDT- 2022/08/08 04:05 PHST- 2022/05/27 00:00 [received] PHST- 2022/07/05 00:00 [accepted] PHST- 2022/08/08 04:05 [entrez] PHST- 2022/08/09 06:00 [pubmed] PHST- 2022/08/09 06:01 [medline] PHST- 2022/07/21 00:00 [pmc-release] AID - 10.3389/fsurg.2022.954530 [doi] PST - epublish SO - Front Surg. 2022 Jul 21;9:954530. doi: 10.3389/fsurg.2022.954530. eCollection 2022. PMID- 28191379 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 9 IP - 1 DP - 2017 Jan 12 TI - Functional and Aesthetic Recovery of Congenital Muscular Torticollis with Intramuscular Stromal Vascular Fraction Enriched Fat Grafting. PG - e975 LID - 10.7759/cureus.975 [doi] LID - e975 AB - Congenital muscular torticollis is a well-known pathological condition caused by the contracture and shortening of the sternocleidomastoid muscle. This condition is manifested by a neck postural deformity often accompanied by some kind of facial asymmetry. Once diagnosed, treatment by early physiotherapy is generally successful in a high percentage of patients if performed during the first year of life. Later, especially after the fourth year, conservative treatment is usually far less effective, and surgical techniques remain the only way to improve neck contour and function. The author reports two cases of adult patients affected by this condition and successfully treated with a novel therapeutic approach consisting of percutaneous myotomies and intramuscular cell-assisted fat grafting. Two cases of adult patients diagnosed with congenital muscular torticollis were analyzed after treatment with percutaneous myotomies and intramuscular fat grafting. The first patient had a history of unsuccessful treatment in infancy with bipolar release of the sternocleidomastoid muscle and was treated with two sessions of fat grafting. The second patient had a history of neglected torticollis and was treated with a single session of cell-assisted fat grafting. In both cases, facial asymmetries were simultaneously treated with the same fat grafting protocol used to treat the muscle. Improvements in muscle function and in face and neck contours were extremely good and stable in both patients. The postoperative course for both patients was uneventful and with a very short and easy recovery when compared with the techniques described to date. Neglected congenital muscular torticollis in adults, or in patients who have not responded adequately to surgical treatment, has been treated safely with percutaneous myotomies and intramuscular fat grafting. The benefit is a scarless technique that provides simultaneous recovery of neck aesthetics and muscle function together with a very short recovery time. Further studies must be conducted to properly evaluate the long-term safety and convenience of cell enrichment to achieve better and long-lasting results. FAU - Monreal, Juan AU - Monreal J AD - Plastic Surgery, Hospital Moncloa. LA - eng PT - Case Reports PT - Journal Article DEP - 20170112 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC5298916 OTO - NOTNLM OT - congenital muscular torticollis OT - fat OT - fat grafting OT - lipofilling OT - sternocleidomastoid muscle OT - stromal vascular fraction COIS- The authors have declared that no competing interests exist. EDAT- 2017/02/14 06:00 MHDA- 2017/02/14 06:01 PMCR- 2017/01/12 CRDT- 2017/02/14 06:00 PHST- 2017/02/14 06:00 [entrez] PHST- 2017/02/14 06:00 [pubmed] PHST- 2017/02/14 06:01 [medline] PHST- 2017/01/12 00:00 [pmc-release] AID - 10.7759/cureus.975 [doi] PST - epublish SO - Cureus. 2017 Jan 12;9(1):e975. doi: 10.7759/cureus.975. PMID- 38235444 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240119 IS - 2673-6195 (Electronic) IS - 2673-6195 (Linking) VI - 3 DP - 2022 TI - Living on the edge: How to prepare for it? PG - 1007774 LID - 10.3389/fnrgo.2022.1007774 [doi] LID - 1007774 AB - INTRODUCTION: Isolated, confined, and extreme (ICE) environments such as found at Antarctic, Arctic, and other remote research stations are considered space-analogs to study the long duration isolation aspects of operational space mission conditions. METHODS: We interviewed 24 sojourners that participated in different short/long duration missions in an Antarctic (Concordia, Halley VI, Rothera, Neumayer II) or non-Antarctic (e.g., MDRS, HI-SEAS) station or in polar treks, offering a unique insight based on first-hand information on the nature of demands by ICE-personnel at multiple levels of functioning. We conducted a qualitative thematic analysis to explore how sojourners were trained, prepared, how they experienced the ICE-impact in function of varieties in environment, provided trainings, station-culture, and type of mission. RESULTS: The ICE-environment shapes the impact of organizational, interpersonal, and individual working- and living systems, thus influencing the ICE-sojourners' functioning. Moreover, more specific training for operating in these settings would be beneficial. The identified pillars such as sensory deprivation, sleep, fatigue, group dynamics, displacement of negative emotions, gender-issues along with coping strategies such as positivity, salutogenic effects, job dedication and collectivistic thinking confirm previous literature. However, in this work, we applied a systemic perspective, assembling the multiple levels of functioning in ICE-environments. DISCUSSION: A systemic approach could serve as a guide to develop future preparatory ICE-training programs, including all the involved parties of the crew system (e.g., family, on-ground crew) with attention for the impact of organization- and station-related subcultures and the risk of unawareness about the impact of poor sleep, fatigue, and isolation on operational safety that may occur on location. CI - Copyright © 2022 Van Puyvelde, Gijbels, Van Caelenberg, Smith, Bessone, Buckle-Charlesworth and Pattyn. FAU - Van Puyvelde, Martine AU - Van Puyvelde M AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Brain, Body and Cognition (BBC), Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium. AD - Clinical and Lifespan Psychology, Department of Psychology, Faculty of Psychology and Educational Sciences, Vrije Universiteit Brussel, Brussels, Belgium. AD - School of Natural Sciences and Psychology, Faculty of Science, Liverpool John Moores University, Liverpool, United Kingdom. FAU - Gijbels, Daisy AU - Gijbels D AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. FAU - Van Caelenberg, Thomas AU - Van Caelenberg T AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. FAU - Smith, Nathan AU - Smith N AD - Protective Security and Resilience Centre, Coventry University, Coventry, United Kingdom. FAU - Bessone, Loredana AU - Bessone L AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. FAU - Buckle-Charlesworth, Susan AU - Buckle-Charlesworth S AD - Human Behavior and Performance Training, European Astronaut Centre, Cologne, Germany. AD - Oxford Human Performance, Oxfordshire, United Kingdom. FAU - Pattyn, Nathalie AU - Pattyn N AD - Vital Signs and PERformance Monitoring (VIPER) Research Unit, Life Sciences (LIFE) Department, Royal Military Academy, Brussels, Belgium. AD - Human Physiology and Human Performance Lab (MFYS-BLITS), Human Physiology Department, Vrije Universiteit Brussel, Brussels, Belgium. LA - eng PT - Journal Article DEP - 20221214 PL - Switzerland TA - Front Neuroergon JT - Frontiers in neuroergonomics JID - 9918663089006676 PMC - PMC10790891 OTO - NOTNLM OT - Antarctica OT - ICE-environment OT - confined OT - extreme environment OT - isolated OT - isolation OT - space-analog OT - training COIS- SB-C was employed by Oxford Human Performance. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/12/14 00:00 MHDA- 2022/12/14 00:01 PMCR- 2022/12/14 CRDT- 2024/01/18 04:24 PHST- 2022/07/30 00:00 [received] PHST- 2022/11/15 00:00 [accepted] PHST- 2022/12/14 00:01 [medline] PHST- 2022/12/14 00:00 [pubmed] PHST- 2024/01/18 04:24 [entrez] PHST- 2022/12/14 00:00 [pmc-release] AID - 10.3389/fnrgo.2022.1007774 [doi] PST - epublish SO - Front Neuroergon. 2022 Dec 14;3:1007774. doi: 10.3389/fnrgo.2022.1007774. eCollection 2022. PMID- 33639443 OWN - NLM STAT- MEDLINE DCOM- 20210609 LR - 20210609 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 153 DP - 2021 Apr TI - Comparison of threshold determination methods for the deceleration rate to avoid a crash (DRAC)-based crash estimation. PG - 106051 LID - S0001-4575(21)00082-8 [pii] LID - 10.1016/j.aap.2021.106051 [doi] AB - There is an increased interest in the use of traffic conflicts as a surrogate safety measure and several traffic conflict indicators have been developed. One of these indicators is the deceleration rate to avoid a crash (DRAC). Generally, the greater the DRAC value, the higher the crash risk and a crash would occur when the DRAC exceeds the maximum available deceleration rate (MADR). It is noted that the MADR varies considerably for individual vehicles and depends on many factors such as the pavement conditions, vehicle weight, tire, and the braking system. Previous studies usually either set a specific value for the MADR or randomly sample values from a truncated normal distribution of MADR. However, little is known about which threshold determination approach is better. Therefore, this study aims to compare the threshold determination approaches for DRAC-based crash estimation applying Bayesian hierarchical extreme value modeling. Using traffic conflict and crash data collected from four signalized intersections in the city of Surrey, several Bayesian hierarchical models are developed for five specific values of MADR and values from two truncated normal distributions of MADR. The crash frequencies estimated from these models were compared with observed crashes. The results show that, in terms of DRAC-based crash estimation accuracy, the truncated normal distribution N(8.45, 1.4(2))I(4.23, 12.68) of MADR outperforms other determination methods of MADR. Moreover, in terms of DRAC-based crash estimation accuracy and precision, the use of multisite Bayesian hierarchical models outperforms the at-site models. The truncated normal distribution N(8.45, 1.4(2))I(4.23, 12.68) of MADR is therefore recommended for DRAC-based crash estimation. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Fu, Chuanyun AU - Fu C AD - School of Transportation and Logistics, Southwest Jiaotong University, China; Department of Civil Engineering, The University of British Columbia, Canada. Electronic address: fcy1128@mail.ubc.ca. FAU - Sayed, Tarek AU - Sayed T AD - Department of Civil Engineering, The University of British Columbia, Canada. Electronic address: tsayed@civil.ubc.ca. LA - eng PT - Comparative Study PT - Journal Article DEP - 20210224 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - *Accidents, Traffic/prevention & control MH - Bayes Theorem MH - Cities MH - *Deceleration MH - Humans OTO - NOTNLM OT - Bayesian hierarchical framework OT - Crash estimation OT - DRAC OT - Extreme value theory OT - MADR OT - Traffic conflicts EDAT- 2021/02/28 06:00 MHDA- 2021/06/10 06:00 CRDT- 2021/02/27 20:12 PHST- 2020/06/19 00:00 [received] PHST- 2020/10/08 00:00 [revised] PHST- 2021/02/14 00:00 [accepted] PHST- 2021/02/28 06:00 [pubmed] PHST- 2021/06/10 06:00 [medline] PHST- 2021/02/27 20:12 [entrez] AID - S0001-4575(21)00082-8 [pii] AID - 10.1016/j.aap.2021.106051 [doi] PST - ppublish SO - Accid Anal Prev. 2021 Apr;153:106051. doi: 10.1016/j.aap.2021.106051. Epub 2021 Feb 24. PMID- 22872305 OWN - NLM STAT- MEDLINE DCOM- 20130305 LR - 20211021 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 28 IP - 10 DP - 2012 Oct TI - Class III gynecomastia in pediatric age: a new modified surgical treatment. PG - 1015-9 AB - BACKGROUND: Prepubertal gynecomastia is an extremely rare condition usually requiring surgical treatment, especially in case of class III gynecomastia. This study presents cases treated with a new surgical treatment. METHODS: From 2010 at our institution, gynecomastia is treated surgically using a modified technique of periareolar incision. Aesthetic results and possible complications of this technique are reported. RESULTS: Five patients were treated at the authors' unit for class III gynecomastia between January 2010 and December 2011. All patients were properly treated without the need of further surgery for skin resection. One patient developed seroma, treated with suction; one patient showed hematoma, treated with hot packs for 3 weeks. All patients and their parents were satisfied of the aesthetic results obtained. All patients resumed sport activities 4 weeks after surgery. It was not possible to observe intraoperative complications. CONCLUSION: The technique used meets safety and efficacy standards for the treatment of this type of pediatric gynecomastia. It also offers the best possible aesthetic results with minimum complications which can be treated without the need of further surgery. FAU - Zampieri, Nicola AU - Zampieri N AD - Department of Surgical Science, Policlinico G.B.Rossi, Pediatric Surgical Unit, University of Verona, Piazzale L.A. Scuro, 37134, Verona, Italy. zampius@libero.it FAU - Castellani, Roberto AU - Castellani R FAU - Modena, Stefano AU - Modena S FAU - Camoglio, Francesco Saverio AU - Camoglio FS LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20120808 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Child MH - Follow-Up Studies MH - Gynecomastia/diagnosis/*surgery MH - Humans MH - Male MH - Mastectomy, Subcutaneous/*methods MH - Patient Satisfaction MH - Retrospective Studies MH - Severity of Illness Index MH - Treatment Outcome EDAT- 2012/08/09 06:00 MHDA- 2013/03/06 06:00 CRDT- 2012/08/09 06:00 PHST- 2012/07/25 00:00 [accepted] PHST- 2012/08/09 06:00 [entrez] PHST- 2012/08/09 06:00 [pubmed] PHST- 2013/03/06 06:00 [medline] AID - 10.1007/s00383-012-3155-x [doi] PST - ppublish SO - Pediatr Surg Int. 2012 Oct;28(10):1015-9. doi: 10.1007/s00383-012-3155-x. Epub 2012 Aug 8. PMID- 30672209 OWN - NLM STAT- MEDLINE DCOM- 20190503 LR - 20190503 IS - 0255-2930 (Print) IS - 0255-2930 (Linking) VI - 38 IP - 11 DP - 2018 Nov 12 TI - [Analysis on the atypical clinical accidents of acupuncture based on the individual factors in patients]. PG - 1245-8 LID - 10.13703/j.0255-2930.2018.11.030 [doi] AB - The hidden risk of acupuncture has become the factor of the high incidence of adverse reaction of acupuncture in clinical practice. The retrospective analysis and the typical cases analysis are especially important for the prevention from the hidden risk of acupuncture. In the paper, the relevant literatures were reviewed, the basic diseases were listed such as diabetes, hypertension and digestive gastric ulcer that were neglected by the physicians, and the adverse reactions induced by the therapeutic history and the body constitutions were analyzed. It was stated in the paper that because of the individual factors of patient, the risks of the atypical clinical accidents of acupuncture were extremely serious and easily neglected by the clinical acupuncture physicians. It is very necessary to remind the clinical acupuncture physicians to understand the basic diseases, basic treatment as well as the peculiarity of body constitution of the patients besides their chief complaints. Moreover, acupuncture should be applied very carefully after identifying the pulse condition and the contraindication so as to ensure the patient's safety and obtain the optimal efficacy. FAU - He, Guanheng AU - He G AD - Guangzhou University of CM, Guangzhou 510405,Guangdong Province, China; Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province. FAU - Ruan, Jingwen AU - Ruan J AD - Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province. FAU - Lv, Xiaozhou AU - Lv X AD - Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province. FAU - Lai, Xinsheng AU - Lai X AD - Clinical Medical College of Acupuncture and Rehabilitation, Guangzhou University of CM. LA - chi PT - Journal Article PL - China TA - Zhongguo Zhen Jiu JT - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JID - 8600658 SB - IM MH - Accidents MH - *Acupuncture Therapy MH - Contraindications MH - Humans MH - Retrospective Studies OTO - NOTNLM OT - adverse reaction, atypical OT - hidden risk OT - individual factors EDAT- 2019/01/24 06:00 MHDA- 2019/05/06 06:00 CRDT- 2019/01/24 06:00 PHST- 2019/01/24 06:00 [entrez] PHST- 2019/01/24 06:00 [pubmed] PHST- 2019/05/06 06:00 [medline] AID - 10.13703/j.0255-2930.2018.11.030 [doi] PST - ppublish SO - Zhongguo Zhen Jiu. 2018 Nov 12;38(11):1245-8. doi: 10.13703/j.0255-2930.2018.11.030. PMID- 34445912 OWN - NLM STAT- MEDLINE DCOM- 20230502 LR - 20230502 IS - 1549-7852 (Electronic) IS - 1040-8398 (Linking) VI - 63 IP - 14 DP - 2023 TI - Overview of strategies for developing high thermostability industrial enzymes: Discovery, mechanism, modification and challenges. PG - 2057-2073 LID - 10.1080/10408398.2021.1970508 [doi] AB - Biocatalysts such as enzymes are environmentally friendly and have substrate specificity, which are preferred in the production of various industrial products. However, the strict reaction conditions in industry including high temperature, organic solvents, strong acids and bases and other harsh environments often destabilize enzymes, and thus substantially compromise their catalytic functions, and greatly restrict their applications in food, pharmaceutical, textile, bio-refining and feed industries. Therefore, developing industrial enzymes with high thermostability becomes very important in industry as thermozymes have more advantages under high temperature. Discovering new thermostable enzymes using genome sequencing, metagenomics and sample isolation from extreme environments, or performing molecular modification of the existing enzymes with poor thermostability using emerging protein engineering technology have become an effective means of obtaining thermozymes. Based on the thermozymes as biocatalytic chips in industry, this review systematically analyzes the ways to discover thermostable enzymes from extreme environment, clarifies various interaction forces that will affect thermal stability of enzymes, and proposes different strategies to improve enzymes' thermostability. Furthermore, latest development in the thermal stability modification of industrial enzymes through rational design strategies is comprehensively introduced from structure-activity relationship point of view. Challenges and future research perspectives are put forward as well. FAU - Wu, Hao AU - Wu H AUID- ORCID: 0000-0002-5532-6564 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. FAU - Chen, Qiuming AU - Chen Q AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhang, Wenli AU - Zhang W AUID- ORCID: 0000-0002-7861-0170 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. FAU - Mu, Wanmeng AU - Mu W AUID- ORCID: 0000-0001-6597-527X AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, Jiangsu, China. LA - eng PT - Journal Article PT - Review DEP - 20210826 PL - United States TA - Crit Rev Food Sci Nutr JT - Critical reviews in food science and nutrition JID - 8914818 RN - 0 (Enzymes) SB - IM MH - Biocatalysis MH - *Food MH - *Metagenomics MH - Protein Engineering MH - Structure-Activity Relationship MH - Enzymes/genetics MH - Enzyme Stability OTO - NOTNLM OT - Thermostability OT - extreme environment OT - industrial enzymes OT - interaction force OT - protein engineering EDAT- 2021/08/28 06:00 MHDA- 2023/05/02 06:41 CRDT- 2021/08/27 05:33 PHST- 2023/05/02 06:41 [medline] PHST- 2021/08/28 06:00 [pubmed] PHST- 2021/08/27 05:33 [entrez] AID - 10.1080/10408398.2021.1970508 [doi] PST - ppublish SO - Crit Rev Food Sci Nutr. 2023;63(14):2057-2073. doi: 10.1080/10408398.2021.1970508. Epub 2021 Aug 26. PMID- 31738617 OWN - NLM STAT- MEDLINE DCOM- 20200203 LR - 20200203 IS - 1744-7666 (Electronic) IS - 1465-6566 (Linking) VI - 21 IP - 1 DP - 2020 Jan TI - Recent developments in pharmacotherapy for hypertriglyceridemia: what's the current state of the art? PG - 107-120 LID - 10.1080/14656566.2019.1691523 [doi] AB - Introduction: Hypertriglyceridemia is associated with both the development of cardiovascular disease (CVD) when mild-to-moderate and high risk of pancreatitis when more severe. The residual CVD risk after low-density lipoprotein cholesterol (LDL-C) lowering is, in part, attributed to high triglyceride (TG) levels. Therefore, there appears to be a need for effective TG-lowering agents.Areas covered: This review presents the most recent advances in hypertriglyceridemia treatment; specifically, it discusses the results of clinical trials and critically comments on apolipoprotein C-III inhibitors, angiopoietin-like 3 inhibitors, alipogene tiparvovec, pradigastat, pemafibrate and novel formulations of omega-3 fatty acids.Expert opinion: In the era of extreme lowering of LDL-C levels with several agents, there seems to be space for novel therapeutic options to combat parameters responsible for residual CVD risk, among which are elevated TGs. Furthermore, a significant number of individuals have very high TG levels and encounter the risk of acute pancreatitis. The most recently developed TG-lowering drugs appear to have a role in both conditions; the choice is mainly based on baseline TG levels. Dyslipidemia guidelines are likely to change in the near future to include some of these agents. Of course, long-term data regarding their safety and efficacy in terms of CVD outcomes and pancreatitis are warranted. FAU - Florentin, Matilda AU - Florentin M AD - Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece. FAU - Kostapanos, Michael S AU - Kostapanos MS AD - Lipid clinic, Department of General Medicine, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. FAU - Anagnostis, Panagiotis AU - Anagnostis P AD - Unit of reproductive endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Liamis, George AU - Liamis G AUID- ORCID: 0000-0003-1522-8318 AD - Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece. LA - eng PT - Journal Article PT - Review DEP - 20191118 PL - England TA - Expert Opin Pharmacother JT - Expert opinion on pharmacotherapy JID - 100897346 RN - 0 (Cholesterol, LDL) RN - 0 (Fatty Acids, Omega-3) RN - 0 (Hypolipidemic Agents) RN - 0 (Triglycerides) SB - IM MH - Acute Disease MH - Cardiovascular Diseases/prevention & control MH - Cholesterol, LDL/blood MH - Fatty Acids, Omega-3/therapeutic use MH - Humans MH - Hypertriglyceridemia/*drug therapy MH - Hypolipidemic Agents/*administration & dosage MH - Pancreatitis/prevention & control MH - Triglycerides/blood OTO - NOTNLM OT - Angiopoietin-like 3 inhibitors OT - docosahexaenoic acid OT - eicosapentaenoic acid OT - pemafibrate OT - pradigastat OT - tiparvovec OT - triglycerides OT - volanesorsen EDAT- 2019/11/19 06:00 MHDA- 2020/02/06 06:00 CRDT- 2019/11/19 06:00 PHST- 2019/11/19 06:00 [pubmed] PHST- 2020/02/06 06:00 [medline] PHST- 2019/11/19 06:00 [entrez] AID - 10.1080/14656566.2019.1691523 [doi] PST - ppublish SO - Expert Opin Pharmacother. 2020 Jan;21(1):107-120. doi: 10.1080/14656566.2019.1691523. Epub 2019 Nov 18. PMID- 33768335 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210417 IS - 2198-7793 (Print) IS - 2198-7793 (Electronic) IS - 2198-7793 (Linking) VI - 7 IP - 1 DP - 2021 Mar 25 TI - Laparoscopic surgery in a patient with foramen of Winslow hernia due to large uterine fibroids: a case report and literature review. PG - 77 LID - 10.1186/s40792-021-01162-2 [doi] LID - 77 AB - BACKGROUND: Foramen of Winslow hernia (FWH) is a rare but emergent condition caused by an increase in the foramen diameter, visceral mobility, and intra-abdominal pressure. To the best of our knowledge, this is the first study to report a case of FWH secondary to large uterine fibroids that was successfully treated with laparoscopic surgery. CASE PRESENTATION: A 52-year-old woman with large uterine fibroids was diagnosed with FWH. Because of the absence of signs of bowel ischemia and peritonitis, we performed an elective laparoscopic surgery through a 5-port system after bowel decompression using a long intestinal tube. Although foramen of Winslow closure was not performed, her postoperative course was uneventful. CONCLUSIONS: Laparoscopic surgery for FWH is considered an extremely effective surgical treatment option because of its safety and efficacy in performing delicate procedures (such as adhesiolysis) with a good magnified field of view. FAU - Honma, Shusaku AU - Honma S AUID- ORCID: 0000-0002-1749-7557 AD - Department of Surgery, Kobe City Medical Center West Hospital, 2-4, Ichibancho, Nagataku, Kobe, Hyogo, 653-0013, Japan. shomma74@kuhp.kyoto-u.ac.jp. FAU - Itohara, Takenori AU - Itohara T AD - Department of General Medicine, Nozaki Tokushukai Hospital, 2-10-5, Tanigawa, Daito, Osaka, 574-0074, Japan. FAU - Sha, Seigo AU - Sha S AD - Department of General Medicine, Nozaki Tokushukai Hospital, 2-10-5, Tanigawa, Daito, Osaka, 574-0074, Japan. FAU - Onoyama, Hirohiko AU - Onoyama H AD - Department of General Medicine, Nozaki Tokushukai Hospital, 2-10-5, Tanigawa, Daito, Osaka, 574-0074, Japan. LA - eng PT - Journal Article DEP - 20210325 PL - Germany TA - Surg Case Rep JT - Surgical case reports JID - 101662125 PMC - PMC7994464 OTO - NOTNLM OT - Foramen of Winslow hernia OT - Internal hernia OT - Laparoscopy OT - Uterine fibroid COIS- All of the authors declare no competing interests. EDAT- 2021/03/27 06:00 MHDA- 2021/03/27 06:01 PMCR- 2021/03/25 CRDT- 2021/03/26 07:07 PHST- 2021/01/20 00:00 [received] PHST- 2021/03/21 00:00 [accepted] PHST- 2021/03/26 07:07 [entrez] PHST- 2021/03/27 06:00 [pubmed] PHST- 2021/03/27 06:01 [medline] PHST- 2021/03/25 00:00 [pmc-release] AID - 10.1186/s40792-021-01162-2 [pii] AID - 1162 [pii] AID - 10.1186/s40792-021-01162-2 [doi] PST - epublish SO - Surg Case Rep. 2021 Mar 25;7(1):77. doi: 10.1186/s40792-021-01162-2. PMID- 21326477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20211020 IS - 0739-9529 (Print) IS - 1098-8963 (Electronic) IS - 0739-9529 (Linking) VI - 24 IP - 3 DP - 2007 Sep TI - Two cases of major hemorrhage secondary to transjugular liver biopsy. PG - 320-3 LID - 10.1055/s-2007-985743 [doi] AB - Transjugular liver biopsy is an essential procedure in the armamentarium of the interventional radiologist for patients who otherwise are unable to undergo percutaneous liver biopsy. Multiple conditions exist that necessitate the transjugular approach for biopsy, including acquired coagulopathy, congenital blood disorders, or requirement for measurements of hepatic venous and/or wedged hepatic vein pressures. The safety and efficacy of transjugular liver biopsy is well established, with many studies citing extremely low rates of complication with high rates of technical success. Nonetheless, transjugular liver biopsy is not without complications. The most often reported complication is asymptomatic capsular perforation; however occasionally, major hemorrhagic complications and even death have been reported. We describe two major hemorrhagic complications that manifested several days after the procedure and required emergent intervention. FAU - Lynskey, George E AU - Lynskey GE AD - Department of Radiology, Georgetown University School of Medicine, Washington, District of Columbia. FAU - Levy, Elliot B AU - Levy EB FAU - Banovac, Filip AU - Banovac F LA - eng PT - Journal Article PL - United States TA - Semin Intervent Radiol JT - Seminars in interventional radiology JID - 8510974 PMC - PMC3036316 OTO - NOTNLM OT - Liver OT - biopsy OT - complication OT - transjugular EDAT- 2007/09/01 00:00 MHDA- 2007/09/01 00:01 PMCR- 2008/09/01 CRDT- 2011/02/18 06:00 PHST- 2011/02/18 06:00 [entrez] PHST- 2007/09/01 00:00 [pubmed] PHST- 2007/09/01 00:01 [medline] PHST- 2008/09/01 00:00 [pmc-release] AID - 10.1055/s-2007-985743 [doi] PST - ppublish SO - Semin Intervent Radiol. 2007 Sep;24(3):320-3. doi: 10.1055/s-2007-985743. PMID- 39302454 OWN - NLM STAT- MEDLINE DCOM- 20241126 LR - 20241209 IS - 1432-1254 (Electronic) IS - 0020-7128 (Print) IS - 0020-7128 (Linking) VI - 68 IP - 12 DP - 2024 Dec TI - Vulnerable to heat stress: gaps in international standard metric thresholds. PG - 2495-2506 LID - 10.1007/s00484-024-02783-6 [doi] AB - Exposure time to heat is increasing with climate change. Heat exposure thresholds are important to inform heat early warning systems, and legislation and guidance for safety in the workplace. It has already been stated that thresholds can be lower for vulnerable groups, including the elderly, pregnant women, children, and those with pre-existing medical conditions due to their reduced ability to thermoregulate their temperature or apply cooling strategies. However, the Wet Bulb Globe Temperature (WBGT) proposed by the international standard organisation (ISO 7243:2017), only takes into account thresholds based on acclimatization status. Therefore in this study we carried out a PRISMA systematic keyword search of "Wet Bulb Globe Temperature" of the Scopus abstract and citation database in August 2023 and a meta-analysis of text extracted from the identified 913 international studies published between December 1957 and July 2023, to investigate heat stress thresholds for different population groups. We find that different thresholds are considered as an indication of heat stress for different population groups. However, critical gaps were identified for the most vulnerable populations, and there are lower numbers of studies on women. Most studies researched adult populations between the ages of 18 and 55 (n = 491), failing to include the youngest and oldest members of society. Based on these findings, we call for targeted investigations to inform effective heat action policies and set early warning thresholds to ensure the safety and wellbeing of the entire population. CI - © 2024. The Author(s). FAU - Brimicombe, C AU - Brimicombe C AUID- ORCID: 0000-0001-5550-1556 AD - Wegener Centre for Climate and Global Change, University of Graz, Brandhofgasse 5, Graz, 8010, Austria. chloe.brimicombe@uni-graz.at. FAU - Gao, C AU - Gao C AD - Aerosol and Climate Lab, Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Faculty of Engineering (LTH), Lund University, Lund, Sweden. FAU - Otto, I M AU - Otto IM AD - Wegener Centre for Climate and Global Change, University of Graz, Brandhofgasse 5, Graz, 8010, Austria. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20240920 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - Humans MH - *Heat Stress Disorders/prevention & control MH - Female MH - Hot Temperature MH - Adult MH - Child MH - Adolescent MH - Male MH - Young Adult MH - Middle Aged MH - Aged MH - Pregnancy MH - Vulnerable Populations PMC - PMC11599290 OTO - NOTNLM OT - Climate change OT - Extreme heat OT - Occupational standards OT - Thermal comfort OT - Workforce COIS- Declarations. Competing interests: No competing interests to declare. EDAT- 2024/09/20 12:56 MHDA- 2024/11/26 12:30 PMCR- 2024/09/20 CRDT- 2024/09/20 11:14 PHST- 2024/05/09 00:00 [received] PHST- 2024/09/14 00:00 [accepted] PHST- 2024/09/04 00:00 [revised] PHST- 2024/11/26 12:30 [medline] PHST- 2024/09/20 12:56 [pubmed] PHST- 2024/09/20 11:14 [entrez] PHST- 2024/09/20 00:00 [pmc-release] AID - 10.1007/s00484-024-02783-6 [pii] AID - 2783 [pii] AID - 10.1007/s00484-024-02783-6 [doi] PST - ppublish SO - Int J Biometeorol. 2024 Dec;68(12):2495-2506. doi: 10.1007/s00484-024-02783-6. Epub 2024 Sep 20. PMID- 34390631 OWN - NLM STAT- MEDLINE DCOM- 20210901 LR - 20210901 IS - 1066-2936 (Print) IS - 1066-2936 (Linking) VI - 48 IP - 3 DP - 2021 Third Quarter TI - Submarine medicine: An overview of the unique challenges, medical concerns, and gaps. PG - 263-278 AB - Submariners face many challenges. For example, they "live where they work" and can be called to duty anytime. They have limited access to open space, natural settings, fresh air, fresh food, sunlight, privacy, exercise, and outside communication. They support a wider range of missions than occur aboard most other Navy vessels. At sea or on shore, submariners work long hours under conditions with little margin for error. They may traverse remote or disputed areas of the ocean far from rescue assets, and must remain vigilant for potential encounters with hostile forces, onboard fires, anomalies in the breathing atmosphere, leaks, undersea collisions, or radiation exposures. If any of these factors cause casualties, the Independent Duty Corpsman (with intermittent advice from shore-based medical personnel), must be ready to provide aid as long as necessary. The challenges of submarine service led to the growth of the unique field of submarine medicine, which has maintained an excellent record of health and safety. This review introduces the field of submarine medicine as practiced in the U.S. Navy, describing its major concerns, giving an overview of the operation of a submarine medical department, and identifying several medical gaps that researchers are working to fill. Submarine medicine already has a stellar record in terms of radiation and atmospheric safety and has made strides in fatigue management. Ongoing work will deliver improved psychological screening and support tools. This report summarizes developments in these and other areas of submarine medicine. CI - Copyright© Undersea and Hyperbaric Medical Society. FAU - Beardslee, Luke A AU - Beardslee LA AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. FAU - Casper, Erica T AU - Casper ET AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. FAU - Lawson, Ben D AU - Lawson BD AD - Naval Submarine Medical Research Laboratory, Submarine Base New London, Groton, Connecticut, U.S. LA - eng PT - Journal Article PT - Review PL - United States TA - Undersea Hyperb Med JT - Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc JID - 9312954 SB - IM MH - Air Pollution, Indoor/prevention & control MH - *Delivery of Health Care/methods MH - Fatigue/complications MH - Humans MH - Mental Health MH - Metabolic Syndrome/diagnosis MH - *Military Personnel/psychology MH - Occupational Diseases/complications/prevention & control/therapy MH - Occupational Exposure MH - Radiation Exposure MH - Remote Consultation MH - *Ships MH - *Submarine Medicine/education/methods MH - Transportation of Patients/methods MH - United States MH - Workplace OTO - NOTNLM OT - extreme environment OT - isolated and confined environment OT - submarine medicine OT - submariner health OT - undersea medicine COIS- The authors of this paper declare no conflicts of interest exist with this submission. EDAT- 2021/08/15 06:00 MHDA- 2021/09/02 06:00 CRDT- 2021/08/14 17:07 PHST- 2021/08/14 17:07 [entrez] PHST- 2021/08/15 06:00 [pubmed] PHST- 2021/09/02 06:00 [medline] PST - ppublish SO - Undersea Hyperb Med. 2021 Third Quarter;48(3):263-278. PMID- 2386453 OWN - NLM STAT- MEDLINE DCOM- 19900920 LR - 20061115 IS - 0095-6562 (Print) IS - 0095-6562 (Linking) VI - 61 IP - 7 DP - 1990 Jul TI - Aviators intoxicated by inhalation of JP-5 fuel vapors. PG - 654-6 AB - This case of intoxication of two aviators by inhalation of JP-5 fuel vapors emphasizes a dangerous safety hazard. One or both aviators experienced burning eyes, nausea, fatigue, impairment of eye-hand coordination, euphoria, and memory defects when their cockpit became overwhelmed with the odor of JP-5 fuel. Physical and laboratory examinations were normal except for their ill appearance, conjunctivitis, and mild hypertension, which resolved without sequelae. Exposure to JP-5 fuel vapor occurs frequently, particularly after acrobatic flight in some aircraft. The neurologic effects and insidious nature of intoxication makes continued operation under such conditions extremely hazardous. The following is recommended: in the event the odor of JP-5 or any noxious or irritating substance is detected in the cockpit, serious consideration should be given to terminating the flight, using precautionary emergency landing procedures and 100% O2. FAU - Porter, H O AU - Porter HO AD - Department of Neurology, Naval Hospital, Bethesda, MD. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Aviat Space Environ Med JT - Aviation, space, and environmental medicine JID - 7501714 RN - 0 (Fuel Oils) RN - 0 (Petroleum) SB - IM MH - *Aerospace Medicine MH - Fuel Oils/*adverse effects MH - Gas Poisoning/*etiology MH - Humans MH - Male MH - Nervous System Diseases/*chemically induced MH - Petroleum/*adverse effects MH - Volatilization OID - NASA: 90351310 EDAT- 1990/07/01 00:00 MHDA- 1990/07/01 00:01 CRDT- 1990/07/01 00:00 PHST- 1990/07/01 00:00 [pubmed] PHST- 1990/07/01 00:01 [medline] PHST- 1990/07/01 00:00 [entrez] PST - ppublish SO - Aviat Space Environ Med. 1990 Jul;61(7):654-6. PMID- 34719911 OWN - NLM STAT- MEDLINE DCOM- 20211102 LR - 20211102 IS - 0042-8787 (Print) IS - 0042-8787 (Linking) VI - 98 IP - 5 DP - 2021 TI - [Transcranial magnetic stimulation for tinnitus treatment]. PG - 74-79 LID - 10.17116/kurort20219805174 [doi] AB - High prevalence of tinnitus, its negative influence on the quality of life and psychoemotional status of patients support need and extreme urgency of further research of various treatment methods. Rhythmic transcranial magnetic stimulation (rTMS) is an effective method of therapy in patients with chronic tinnitus. The optimal protocol for rhythmic stimulation is low-frequency (1 Hz) rTMS with low-intensity stimuli (below 110% of the motor threshold) with a limited number of stimuli per series. There is evidence that high-frequency rTMS in the area of relatively thin temporal bones can lead to excessive stimulation of the neural structures of the auditory cortex, which is undesirable considering the pathogenesis of this condition. The use of navigation technology in rTMS has no advantage in chronic tinnitus therapy, whereas the combined use of rTMS and transcranial electrical brain stimulation to increase the treatment efficacy is under active study. Considering the attributable favorable clinical safety profile of rTMS, as well as its known positive effects on anxiety and depression that are often seen in patients with tinnitus, we can recommend more widespread use of this method in real-world settings. FAU - Voytenkov, V B AU - Voytenkov VB AUID- ORCID: 0000-0003-0448-7402 AD - Research and Clinical Center for Pediatric Infectious Diseases of the Federal Medical and Biological Agency of Russia, St. Petersburg, Russia. AD - Academy of Postgraduate Education under the Federal State Budgetary Unit «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency», Moscow, Russia. AD - Federal Scientific Center of Rehabilitation of the Disabled named after G.A. Albrecht, St. Petersburg, Russia. FAU - Ekusheva, E V AU - Ekusheva EV AUID- ORCID: 0000-0002-3638-6094 AD - Academy of Postgraduate Education under the Federal State Budgetary Unit «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency», Moscow, Russia. AD - Belgorod State University, Belgorod, Russia. FAU - Bedova, M A AU - Bedova MA AUID- ORCID: 0000-0001-8924-5300 AD - Research and Clinical Center for Pediatric Infectious Diseases of the Federal Medical and Biological Agency of Russia, St. Petersburg, Russia. FAU - Komazov, A A AU - Komazov AA AD - Academy of Postgraduate Education under the Federal State Budgetary Unit «Federal Scientific and Clinical Center for Specialized Medical Assistance and Medical Technologies of the Federal Medical Biological Agency», Moscow, Russia. AD - Belgorod State University, Belgorod, Russia. LA - rus PT - Journal Article TT - Transkranial'naya magnitnaya stimulyatsiya v lechenii tinnitusa. PL - Russia (Federation) TA - Vopr Kurortol Fizioter Lech Fiz Kult JT - Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury JID - 2984868R SB - IM MH - *Auditory Cortex MH - Chronic Disease MH - Double-Blind Method MH - Humans MH - Quality of Life MH - *Tinnitus/therapy MH - Transcranial Magnetic Stimulation MH - Treatment Outcome OTO - NOTNLM OT - rhythmic transcranial magnetic stimulation OT - tinnitus OT - transcranial magnetic stimulation EDAT- 2021/11/02 06:00 MHDA- 2021/11/03 06:00 CRDT- 2021/11/01 06:50 PHST- 2021/11/01 06:50 [entrez] PHST- 2021/11/02 06:00 [pubmed] PHST- 2021/11/03 06:00 [medline] AID - 10.17116/kurort20219805174 [doi] PST - ppublish SO - Vopr Kurortol Fizioter Lech Fiz Kult. 2021;98(5):74-79. doi: 10.17116/kurort20219805174. PMID- 32507491 OWN - NLM STAT- MEDLINE DCOM- 20200907 LR - 20200907 IS - 1097-6760 (Electronic) IS - 0196-0644 (Linking) VI - 76 IP - 2 DP - 2020 Aug TI - Clinical Implications of Climate Change on US Emergency Medicine: Challenges and Opportunities. PG - 168-178 LID - S0196-0644(20)30192-X [pii] LID - 10.1016/j.annemergmed.2020.03.010 [doi] AB - The adverse influences of climate change are manifesting as health burdens relevant to clinical practice, affecting the very underpinnings of health and stressing the health care system. Emergency medicine is likely to bear a large burden, with its focus on urgent and emergency care, through its role as a safety-net provider for vulnerable populations and as a leader in disaster medicine. Clinically, climate change is affecting emergency medicine practice through the amplification of climate-related disease patterns and epidemiologic shifts for conditions diagnosed and treated in emergency departments (EDs), especially for vulnerable populations. In addition, climate-driven intensification of extreme weather is disrupting health care delivery in EDs and health care systems. Thus, there are significant opportunities for emergency medicine to lead the medical response to climate change through 7 key areas: clinical practice improvements, building resilient EDs and health care systems, adaptation and public health engagement, disaster preparedness, mitigation, research, and education. In the face of this growing health threat, systemwide preparation rooted in local leadership and responsiveness is necessary to efficiently and effectively care for our vulnerable communities. CI - Copyright © 2020 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved. FAU - Sorensen, Cecilia J AU - Sorensen CJ AD - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO. Electronic address: Cecilia.Sorensen@cuanschutz.edu. FAU - Salas, Renee N AU - Salas RN AD - Center for Social Justice & Health Equity, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA; Harvard Global Health Institute, Cambridge, MA; Center for Climate, Health and the Global Environment, Harvard T.H. Chan School of Public Health. FAU - Rublee, Caitlin AU - Rublee C AD - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO. FAU - Hill, Kimberly AU - Hill K AD - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Department of Emergency Medicine, Denver Health Medical Center, Denver, CO. FAU - Bartlett, Emily S AU - Bartlett ES AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA. FAU - Charlton, Paul AU - Charlton P AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA. FAU - Dyamond, Chelsea AU - Dyamond C AD - Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO; Department of Emergency Medicine, Denver Health Medical Center, Denver, CO. FAU - Fockele, Callan AU - Fockele C AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA. FAU - Harper, Rachel AU - Harper R AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA. FAU - Barot, Sabiha AU - Barot S AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA. FAU - Calvello-Hynes, Emilie AU - Calvello-Hynes E AD - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO. FAU - Hess, Jeremy AU - Hess J AD - Department of Emergency Medicine, Harborview Medical Center, University of Washington, Seattle, WA; Department of Environmental and Occupational Health Sciences and Center for Health and the Global Environment, University of Washington, Seattle, WA. FAU - Lemery, Jay AU - Lemery J AD - Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO; Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO. LA - eng PT - Journal Article DEP - 20200602 PL - United States TA - Ann Emerg Med JT - Annals of emergency medicine JID - 8002646 SB - IM MH - Cardiovascular Diseases MH - Chronic Disease MH - *Climate Change MH - *Delivery of Health Care MH - Disaster Medicine MH - *Disasters MH - *Emergency Medicine MH - Emergency Service, Hospital MH - Heat Stress Disorders MH - Humans MH - Mental Disorders MH - *Public Health MH - Respiratory Tract Diseases MH - Social Class MH - United States MH - Vector Borne Diseases MH - *Vulnerable Populations MH - Wounds and Injuries EDAT- 2020/06/09 06:00 MHDA- 2020/09/08 06:00 CRDT- 2020/06/09 06:00 PHST- 2019/11/24 00:00 [received] PHST- 2020/03/05 00:00 [revised] PHST- 2020/03/09 00:00 [accepted] PHST- 2020/06/09 06:00 [pubmed] PHST- 2020/09/08 06:00 [medline] PHST- 2020/06/09 06:00 [entrez] AID - S0196-0644(20)30192-X [pii] AID - 10.1016/j.annemergmed.2020.03.010 [doi] PST - ppublish SO - Ann Emerg Med. 2020 Aug;76(2):168-178. doi: 10.1016/j.annemergmed.2020.03.010. Epub 2020 Jun 2. PMID- 26628876 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20151202 LR - 20181113 IS - 1198-0052 (Print) IS - 1718-7729 (Electronic) IS - 1198-0052 (Linking) VI - 22 IP - 5 DP - 2015 Oct TI - Human albumin eye drops as a therapeutic option for the management of keratoconjunctivitis sicca secondary to chronic graft-versus-host disease after stem-cell allografting. PG - e357-63 LID - 10.3747/co.22.2620 [doi] AB - BACKGROUND: Keratoconjunctivitis sicca from chronic graft-versus-host disease (cgvhd) after allogeneic stem cell transplantation is common, leading to severe corneal damage and blindness if not treated. We retrospectively examined the efficacy and safety of pooled human albumin eye drops (haeds) for symptom relief in 40 stem-cell transplantation patients after other alternatives had failed. METHODS: The Common Terminology Criteria for Adverse Events (version 4.0) and the cgvhd grading scale were used to compare response in the patients during January 2000 and July 2013. In addition, on days 1 and 30, the haeds were subjected to quality assurance testing for sterility, oncotic pressure, albumin measurement, viscosity, pH, and purity by protein electrophoresis. RESULTS: Use of haeds resulted in symptom relief for 37 patients (92.5%); 3 patients (7.5%) failed to improve with use of haeds (p ≤ 0.0001). Of the 37 patients having symptom relief, 7 (19%) improved from grade 3 to no dry eye symptoms. Proportionately, post-treatment symptom improvement by two grade levels, from 3 to 1 (70%), was significantly higher than improvement by one grade level, from 3 to 2 (11%) or from 2 to 1 (19%, p ≤ 0.0001). Time to symptom relief ranged from 2 weeks to 28 weeks. Of the 40 patients, 38 (95%) had no adverse reactions. Days 1 and 30 quality assurance testing results were equivalent. CONCLUSIONS: Complications of keratoconjunctivitis sicca were well managed and well tolerated with haeds when other remedies failed. Quality assurance testing confirmed that haeds were safe and stable in extreme conditions. FAU - Seki, J T AU - Seki JT AD - Princess Margaret Cancer Centre, Toronto, ON; ; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON; ; College of Pharmacy and Health Sciences, Drake University, IA, U.S.A.; FAU - Sakurai, N AU - Sakurai N AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Moldenhauer, S AU - Moldenhauer S AD - Princess Margaret Cancer Centre, Toronto, ON; ; College of Pharmacy and Health Sciences, Drake University, IA, U.S.A.; FAU - Dam, J AU - Dam J AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Atenafu, E G AU - Atenafu EG AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Yip, P M AU - Yip PM AD - Toronto General Hospital, Toronto, ON; FAU - Mazzulli, T AU - Mazzulli T AD - Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON; ; Mount Sinai Hospital, Toronto, ON; FAU - Henderson, T AU - Henderson T AD - The Hospital for Sick Children, Toronto, ON. FAU - Pendergrast, J AU - Pendergrast J AD - Toronto General Hospital, Toronto, ON; FAU - Cserti, C AU - Cserti C AD - Toronto General Hospital, Toronto, ON; FAU - Velazquez, J P AU - Velazquez JP AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Simpson, R AU - Simpson R AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Felluga, G AU - Felluga G AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Messner, H A AU - Messner HA AD - Princess Margaret Cancer Centre, Toronto, ON; FAU - Lipton, J H AU - Lipton JH AD - Princess Margaret Cancer Centre, Toronto, ON; LA - eng PT - Journal Article PL - Switzerland TA - Curr Oncol JT - Current oncology (Toronto, Ont.) JID - 9502503 PMC - PMC4608409 OTO - NOTNLM OT - Post-transplant dry eye management EDAT- 2015/12/03 06:00 MHDA- 2015/12/03 06:01 PMCR- 2015/10/01 CRDT- 2015/12/03 06:00 PHST- 2015/12/03 06:00 [entrez] PHST- 2015/12/03 06:00 [pubmed] PHST- 2015/12/03 06:01 [medline] PHST- 2015/10/01 00:00 [pmc-release] AID - conc-22-e357 [pii] AID - 10.3747/co.22.2620 [doi] PST - ppublish SO - Curr Oncol. 2015 Oct;22(5):e357-63. doi: 10.3747/co.22.2620. PMID- 35313304 OWN - NLM STAT- MEDLINE DCOM- 20220907 LR - 20220907 IS - 1421-9832 (Electronic) IS - 1018-8665 (Linking) VI - 238 IP - 5 DP - 2022 TI - Air Pollution and Weather Conditions Are Associated with Daily Outpatient Visits of Atopic Dermatitis in Shanghai, China. PG - 939-949 LID - 10.1159/000522491 [doi] AB - BACKGROUND: Non-optimum weather conditions and air pollution have the potential to increase the risk of atopic dermatitis (AD), but the associations are rarely evaluated, especially in developing countries. OBJECTIVE: To investigate the independent influence and interaction effects of meteorological factors and air pollutants on the onset of AD. METHODS: Daily data on outpatient visits of AD were obtained from Shanghai Dermatology Hospital and comprised 34,633 patients during the period from January 2013 to December 2018. Meteorological conditions and air pollutant concentrations in Shanghai, China, during the 6-year period were collected. We applied the overdispersed generalized additive model and the distributed lag model to explore the short-term cumulative effects of environmental factors on AD. RESULTS: AD symptoms were aggravated by extreme low temperature (1st percentile, 0.5°C) (RR = 1.32, 95% CI: 1.16-1.51) and per 10 unit decrease of humidity (RR = 1.10, 95% CI: 1.12-2.47). The increased concentration of air pollutants except ozone (O3) contributed to the increased risk of AD outpatients. A 10 μg/m3 increase in sulfur dioxide (SO2) and nitrogen dioxide (NO2) were associated with 6.03% (95% CI: 2.29%, 9.91%), and 1.96% (95% CI: 0.46%, 3.48%) increase of AD outpatients. AD patients in the 8- to 17-year-old group were most susceptible to extreme low temperature, and patients in the 0- to 7-year-old group were most susceptible to air pollutants, including particulate matter (PM10), SO2, and NO2. Men were more sensitive to the effects of extreme low temperature than women, while women were more vulnerable to air pollutants. The adverse effects of SO2 and NO2 on AD can be enhanced significantly by the warm season or other pollutants. CONCLUSION: Exposure to a lower temperature, lower humidity, and higher levels of air pollutants is significantly associated with increased risks of AD incidence. These impacts were more pronounced in children less than 7 years old, women, and warm seasons. CI - © 2022 S. Karger AG, Basel. FAU - Ye, Chengbin AU - Ye C AD - Skin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Gu, Huijing AU - Gu H AD - Skin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. FAU - Li, Mengyi AU - Li M AD - Program in Public Health, University of California, Irvine, California, USA. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China. FAU - Xiao, Xiang AU - Xiao X AD - Department of Science and Education, Shanghai Municipal Health Commission, Shanghai, China. FAU - Zou, Ying AU - Zou Y AD - Skin and Cosmetic Research Department, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20220321 PL - Switzerland TA - Dermatology JT - Dermatology (Basel, Switzerland) JID - 9203244 RN - 0 (Air Pollutants) RN - S7G510RUBH (Nitrogen Dioxide) SB - IM MH - Adolescent MH - *Air Pollutants/adverse effects/analysis MH - *Air Pollution/adverse effects/analysis MH - Child MH - Child, Preschool MH - China/epidemiology MH - *Dermatitis, Atopic/epidemiology/etiology MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Nitrogen Dioxide/analysis MH - Outpatients MH - Weather OTO - NOTNLM OT - Air pollutants OT - Atopic dermatitis OT - Meteorological factors OT - Outpatient visit EDAT- 2022/03/22 06:00 MHDA- 2022/09/08 06:00 CRDT- 2022/03/21 20:12 PHST- 2021/07/26 00:00 [received] PHST- 2022/02/06 00:00 [accepted] PHST- 2022/03/22 06:00 [pubmed] PHST- 2022/09/08 06:00 [medline] PHST- 2022/03/21 20:12 [entrez] AID - 000522491 [pii] AID - 10.1159/000522491 [doi] PST - ppublish SO - Dermatology. 2022;238(5):939-949. doi: 10.1159/000522491. Epub 2022 Mar 21. PMID- 29455491 OWN - NLM STAT- MEDLINE DCOM- 20180629 LR - 20181202 IS - 1003-0034 (Print) IS - 1003-0034 (Linking) VI - 30 IP - 9 DP - 2017 Sep 25 TI - [Percataneous endoscopic lumbar discectomy for the treatment of lumbar intervertebral disc protrusion]. PG - 861-865 LID - 10.3969/j.issn.1003-0034.2017.09.016 [doi] AB - OBJECTIVE: To explore the clinical effects of percataneous endoscopic lumbar discectomy for lumbar intervertebral disc protrusion. METHODS: The clinical data of 46 patients with lumbar intervertebral disc protrusion underwent percataneous endoscopic lumbar discectomy were retrospectively analyzed. There were 21 males and 25 females, aged from 23 to 65 years old with an average of 42 years. The course of disease was from 5 to 87 months with an average of 13.4 months. Protrusion located in L₂,₃ of 2 cases, L₃,₄ of 3 cases, L₄,₅ of 28 cases, L₅S₁ of 13 cases. There were 5 patients with central type, 34 with para-side type, 7 with extreme lateral type. VAS, ODI and JOA scores were used to analyze the condition of pain releasing and lumbar functional improvement. According to MacNab standard to evaluate the clinical effect at final follow-up. RESULTS: All the operations were successful, operative time was 125 to 210 min with a mean of 153.6 min; and all the patients were follow-up for 6 to 12 months with an average of 8 months; no injuries of nerve and blood vessel, infection were found. Postoperative 3 days and final follow-up, VAS score was 3.1±0.7, 2.2±0.6 respectively, and was obviously lower than preoperative 7.3±1.2(P<0.05). At final follow-up, JOA and ODI were (23.5±2.4) points, and (22.10±9.26)%, respectively, and was obviously improved compared with preoperative (13.2±2.8) points and (69.12±13.15)% (P<0.05). According to modified MacNab standard to evaluate the clinical outcome, 30 cases got excellent results, 14 good, 2 fair, no recurred and overhauling were found. CONCLUSIONS: Percataneous endoscopic lumbar discectomy is a minimally invasive technique, with advantage of safety and effectiveness, and apply to treatment of lumbar intervertebral disc protrusion. FAU - Wu, Guan-Nan AU - Wu GN AD - The First Department of Spinal Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. FAU - Zhang, Shi-Min AU - Zhang SM AD - The First Department of Spinal Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China; smzhang1117@163.com. FAU - Jin, Jiao AU - Jin J AD - The First Department of Spinal Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. FAU - Sun, Bi-Qian AU - Sun BQ AD - The First Department of Spinal Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. LA - chi PT - Journal Article PL - China TA - Zhongguo Gu Shang JT - Zhongguo gu shang = China journal of orthopaedics and traumatology JID - 9815790 SB - IM MH - Adult MH - Aged MH - Diskectomy/*methods MH - Endoscopy/methods MH - Female MH - Humans MH - Intervertebral Disc MH - Intervertebral Disc Displacement/*surgery MH - Lumbar Vertebrae/*surgery MH - Male MH - Middle Aged MH - Retrospective Studies MH - Treatment Outcome OTO - NOTNLM OT - Diskectomy, percutaneous OT - Endoscopes OT - Intervertebral disk displacement OT - Lumbar vertebrae OT - Surgical procedures, minimally invasive COIS- The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose. EDAT- 2018/02/20 06:00 MHDA- 2018/06/30 06:00 CRDT- 2018/02/19 06:00 PHST- 2017/07/10 00:00 [received] PHST- 2018/02/19 06:00 [entrez] PHST- 2018/02/20 06:00 [pubmed] PHST- 2018/06/30 06:00 [medline] AID - 10.3969/j.issn.1003-0034.2017.09.016 [doi] PST - ppublish SO - Zhongguo Gu Shang. 2017 Sep 25;30(9):861-865. doi: 10.3969/j.issn.1003-0034.2017.09.016. PMID- 26939870 OWN - NLM STAT- MEDLINE DCOM- 20180111 LR - 20181023 IS - 2044-5423 (Electronic) IS - 2044-5415 (Linking) VI - 26 IP - 3 DP - 2017 Mar TI - The denominator problem: national hospital quality measures for acute myocardial infarction. PG - 189-199 LID - 10.1136/bmjqs-2015-004888 [doi] AB - BACKGROUND: National Hospital Quality Measures (NHQM) should accurately reflect quality of care, as they increasingly impact reimbursement and reputation. However, similar to risk adjustment of outcomes measures, NHQM process measures pose unique methodological concerns, including lack of representativeness of the final denominator population after exclusions. This study determines population size and characteristics for each acute myocardial infarction (AMI) measure, reasons for exclusion from the measures, and variation in exclusion rates among hospitals. METHODS AND RESULTS: 163 144 discharges from 172 University HealthSystem Consortium hospitals between 2008-Q4 and 2013-Q3 were examined, including characteristics and propensity scores of included and excluded groups. Measure exclusions ranged from 17.8% (discharge aspirin) to 90.1% (percutaneous coronary intervention, PCI, within 90 min), with substantial variation across hospitals. Median annual denominator size (IQR) for PCI within 90 min was 28 (20, 44) at major teaching hospitals, versus 10 (0, 25) at non-teaching hospitals. Patients most likely to be excluded (in the 10th vs 1st propensity decile) were older (mean age (SD) of 78.1 (10.8) vs 50.3 (8.6) years), more likely to have Medicare (90.5% vs 0.9%), had more documented comorbidities (15.6 (4.6) vs 6.2 (2.5) hierarchical clinical condition categories) and higher admission mortality risk (Major or Extreme 80.9% vs 7.3%, respectively), and experienced higher inpatient mortality (10.0% vs 1.6%). CONCLUSIONS: Exclusion from AMI measures varied substantially among hospitals, sample sizes were very small for some measures (PCI and ACE inhibitor measures) and measures often excluded high-risk populations. This has implications for the representativeness and comparability of the measures and provides insight for future measure development. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. FAU - Bruckel, Jeffrey AU - Bruckel J AD - Department of Cardiology, University of Rochester Medical Center, Rochester, New York, USA. FAU - Liu, Xiu AU - Liu X AD - Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Hohmann, Samuel F AU - Hohmann SF AD - University HealthSystem Consortium, Chicago, Illinois, USA. FAU - Karson, Andrew S AU - Karson AS AD - Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Mort, Elizabeth AU - Mort E AD - Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Shahian, David M AU - Shahian DM AD - Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Surgery, Center for Quality and Safety, Massachusetts General Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article DEP - 20160303 PL - England TA - BMJ Qual Saf JT - BMJ quality & safety JID - 101546984 CIN - BMJ Qual Saf. 2017 Mar;26(3):169-173. doi: 10.1136/bmjqs-2016-005254. PMID: 27095853 MH - *Acute Disease MH - Comorbidity MH - Databases, Factual MH - *Hospitals MH - Humans MH - Myocardial Infarction/*drug therapy MH - Quality Indicators, Health Care/*standards MH - Severity of Illness Index MH - Time Factors MH - United States OTO - NOTNLM OT - Health policy OT - Pay for performance OT - Performance measures OT - Quality measurement EDAT- 2016/03/05 06:00 MHDA- 2018/01/13 06:00 CRDT- 2016/03/05 06:00 PHST- 2015/09/28 00:00 [received] PHST- 2016/01/28 00:00 [revised] PHST- 2016/02/04 00:00 [accepted] PHST- 2016/03/05 06:00 [pubmed] PHST- 2018/01/13 06:00 [medline] PHST- 2016/03/05 06:00 [entrez] AID - bmjqs-2015-004888 [pii] AID - 10.1136/bmjqs-2015-004888 [doi] PST - ppublish SO - BMJ Qual Saf. 2017 Mar;26(3):189-199. doi: 10.1136/bmjqs-2015-004888. Epub 2016 Mar 3. PMID- 18598041 OWN - NLM STAT- MEDLINE DCOM- 20080929 LR - 20131121 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 56 IP - 15 DP - 2008 Aug 13 TI - Changes in the chemical composition of reduced cooked musts during the heating process. PG - 6397-407 LID - 10.1021/jf800353a [doi] AB - Cooked must is the starting raw material in Aceto Balsamico Tradizionale di Modena (ABTM) production, and the cooking process is a crucial step to ensure quality and safety standards. In particular, the furfural content has to be strictly monitored. In this study, we followed, directly at the production plant, nine cooking processes, differing for grape type and process conditions in order to monitor the actual variability in cooked must reduction. 5-Hydroxymethylfurfural (5-HMF) and furfural contents were determined by high performance liquid chromatography (HPLC) technique and glucose, fructose, and tartaric and malic acids by gas chromatography (GC) technique. Furthermore, some bulk properties, such as the water content, refractive index, density, and total acidity, were also measured. The obtained results show that the product undergoes, in the worse operating conditions, remarkable degradation, leading to extremely high levels of furfurals (5-HMF and furfural), corresponding to a water content lower than 40%. On the basis of these results, a first draft of an optimal heating protocol may be suggested in order to guarantee the safety and quality of the final product. FAU - Cocchi, Marina AU - Cocchi M AD - Dipartimento di Chimica, Universita di Modena e Reggio Emilia, via Campi 183, 41100 Modena, Italia. FAU - Consonni, Roberto AU - Consonni R FAU - Durante, Caterina AU - Durante C FAU - Grandi, Margherita AU - Grandi M FAU - Manzini, Simona AU - Manzini S FAU - Marchetti, Andrea AU - Marchetti A FAU - Sighinolfi, Simona AU - Sighinolfi S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080704 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 059QF0KO0R (Water) RN - 70ETD81LF0 (5-hydroxymethylfurfural) RN - DJ1HGI319P (Furaldehyde) SB - IM MH - Food Contamination/*analysis MH - Food Handling/methods MH - Fruit/*chemistry MH - Furaldehyde/analogs & derivatives/analysis MH - *Hot Temperature MH - Vitis/*chemistry MH - Water/analysis EDAT- 2008/07/05 09:00 MHDA- 2008/09/30 09:00 CRDT- 2008/07/05 09:00 PHST- 2008/07/05 09:00 [pubmed] PHST- 2008/09/30 09:00 [medline] PHST- 2008/07/05 09:00 [entrez] AID - 10.1021/jf800353a [doi] PST - ppublish SO - J Agric Food Chem. 2008 Aug 13;56(15):6397-407. doi: 10.1021/jf800353a. Epub 2008 Jul 4. PMID- 23305573 OWN - NLM STAT- MEDLINE DCOM- 20130802 LR - 20130111 IS - 1525-1594 (Electronic) IS - 0160-564X (Linking) VI - 37 IP - 1 DP - 2013 Jan TI - A nonocclusive, inexpensive pediatric pulsatile roller pump for cardiopulmonary bypass, extracorporeal life support, and left/right ventricular assist systems. PG - 48-56 LID - 10.1111/aor.12026 [doi] AB - A simple, inexpensive pediatric pulsatile roller blood pump has been utilized for routine cardiopulmonary bypass (CPB) procedures, extracorporeal life support (ECLS), and left/right ventricular assist systems (LVAS/RVAS) for decades in France. This particular nonocclusive pulsatile system has many advantages including several safety features for patients as well as an extremely lower cost. The objective of this study is to evaluate the performance of this particular system for CPB, ECLS, and LVAS/RVAS in pulsatile mode. This pediatric nonocclusive system was evaluated with pump flow rates of 500, 750, and 1000 mL/min under normothermic (35°C) and hypothermic (25°C) conditions in CPB, ECLS, and LVAS/RVAS circuits using clinical disposables and settings. Energy equivalent pressure (EEP), surplus homodynamic energy (SHE), and total hemodynamic energy (THE) were calculated for each experimental stage. The pump generated near physiological quality of pulsatile flow without backflow in the three simulated pediatric circuits. With increased flow rates, more hemodynamic energy was delivered to the pseudo patient. This particular nonocclusive pediatric pulsatile system performed well during all of the experimental conditions and generated adequate quality pulsatile pressure-flow waveforms using CPB, ECLS, and LVAS/RVAS circuitry. Although this novel concept was first introduced in the 1990s, we believe that there is still need for this technology (with engineering modifications) because of significant advantages including safety and cost. CI - © 2013, Copyright the Authors. Artificial Organs © 2013, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc. FAU - Wang, Shigang AU - Wang S AD - Department of Pediatrics, Department of Surgery and Bioengineering, Penn State Hershey Pediatric Cardiovascular Research Center, Penn State Hershey Children's Hospital, Hershey, PA 17033-0850, USA. FAU - Durandy, Yves AU - Durandy Y FAU - Kunselman, Allen R AU - Kunselman AR FAU - Ündar, Akif AU - Ündar A LA - eng PT - Journal Article PL - United States TA - Artif Organs JT - Artificial organs JID - 7802778 SB - IM MH - Cardiopulmonary Bypass/*instrumentation MH - Energy Metabolism MH - Equipment Design MH - Extracorporeal Membrane Oxygenation/*instrumentation MH - France MH - Heart-Assist Devices MH - Hemodynamics MH - Humans MH - Pulsatile Flow MH - Transducers, Pressure EDAT- 2013/01/12 06:00 MHDA- 2013/08/03 06:00 CRDT- 2013/01/12 06:00 PHST- 2013/01/12 06:00 [entrez] PHST- 2013/01/12 06:00 [pubmed] PHST- 2013/08/03 06:00 [medline] AID - 10.1111/aor.12026 [doi] PST - ppublish SO - Artif Organs. 2013 Jan;37(1):48-56. doi: 10.1111/aor.12026. PMID- 34577252 OWN - NLM STAT- MEDLINE DCOM- 20210929 LR - 20240403 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 18 DP - 2021 Sep 9 TI - Optical Fibre-Based Sensors for Oil and Gas Applications. LID - 10.3390/s21186047 [doi] LID - 6047 AB - Oil and gas (O&G) explorations moving into deeper zones for enhanced oil and gas recovery are causing serious safety concerns across the world. The sensing of critical multiple parameters like high pressure, high temperature (HPHT), chemicals, etc., are required at longer distances in real-time. Traditional electrical sensors operate less effectively under these extreme environmental conditions and are susceptible to electromagnetic interference (EMI). Hence, there is a growing demand for improved sensors with enhanced measurement capabilities and also sensors that generates reliable data for enhanced oil and gas production. In addition to enhanced oil and gas recovery, the sensing technology should also be capable of monitoring the well bore integrity and safety. The sensing requirements of the O&G industry for improved sensing in deeper zones include increased transmission length, improved spatial coverage and integration of multiple sensors with multimodal sensing capability. This imposes problems like signal attenuation, crosstalks and cross sensitivities. Optical fibre-based sensors are expected to provide superior sensing capabilities compared to electrical sensors. This review paper covers a detailed review of different fibre-optic sensing technologies to identify a feasible sensing solution for the O&G industry. FAU - Johny, Jincy AU - Johny J AUID- ORCID: 0000-0001-8673-5312 AD - School of Engineering, Robert Gordon University, Aberdeen AB10 7GJ, UK. FAU - Amos, Solomon AU - Amos S AD - Department of Computer Science, Deramore Lane, University of York, Heslington, York YO10 5GH, UK. FAU - Prabhu, Radhakrishna AU - Prabhu R AUID- ORCID: 0000-0003-0642-8342 AD - School of Engineering, Robert Gordon University, Aberdeen AB10 7GJ, UK. LA - eng PT - Journal Article PT - Review DEP - 20210909 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Fiber Optic Technology MH - Hot Temperature MH - *Optical Fibers PMC - PMC8473273 OTO - NOTNLM OT - oil and gas OT - optical fibre OT - sensor COIS- No conflict of interest. EDAT- 2021/09/29 06:00 MHDA- 2021/09/30 06:00 PMCR- 2021/09/09 CRDT- 2021/09/28 01:22 PHST- 2021/06/17 00:00 [received] PHST- 2021/08/06 00:00 [revised] PHST- 2021/08/25 00:00 [accepted] PHST- 2021/09/28 01:22 [entrez] PHST- 2021/09/29 06:00 [pubmed] PHST- 2021/09/30 06:00 [medline] PHST- 2021/09/09 00:00 [pmc-release] AID - s21186047 [pii] AID - sensors-21-06047 [pii] AID - 10.3390/s21186047 [doi] PST - epublish SO - Sensors (Basel). 2021 Sep 9;21(18):6047. doi: 10.3390/s21186047. PMID- 39858597 OWN - NLM STAT- MEDLINE DCOM- 20250125 LR - 20250130 IS - 2073-4425 (Electronic) IS - 2073-4425 (Linking) VI - 16 IP - 1 DP - 2025 Jan 3 TI - The Genetic Determinants of Listeria monocytogenes Resistance to Bacteriocins Produced by Lactic Acid Bacteria. LID - 10.3390/genes16010050 [doi] LID - 50 AB - BACKGROUND: Listeria monocytogenes is a Gram-positive bacterium responsible for listeriosis, a serious foodborne disease that can lead to serious health complications. Pregnant women, newborns, the elderly, and patients with weakened immune systems are particularly susceptible to infection. Due to the ability of L. monocytogenes to survive in extreme environmental conditions, such as low temperatures, high salinity, and acidity, this bacterium poses a serious threat to food production plants and is particularly difficult to eliminate from these plants. One of the promising solutions to reduce the presence of this bacterium in food products is bacteriocins as natural control agents. These are substances with antibacterial activity produced by other bacteria, mainly lactic acid bacteria (LAB), which can effectively inhibit the development of pathogens such as L. monocytogenes. The use of bacteriocins in the food industry is beneficial due to their natural origin, specificity of action, and consumer safety. However, the problem of resistance to these substances exists. RESULTS: This review focuses on the mechanisms of bacteriocin resistance, such as modifications of bacteriocin docking receptors, changes in the structure of the cell wall and membrane, and the occurrence of cross-resistance to different bacteriocins. Genetic factors determining these mechanisms and strategies to cope with the problem of resistance are also presented. CONCLUSIONS: Research on this issue is crucial for developing effective preventive methods that will enable the safe and long-term use of bacteriocins in food production. FAU - Zawiasa, Anna AU - Zawiasa A AUID- ORCID: 0009-0001-0374-9899 AD - Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. FAU - Olejnik-Schmidt, Agnieszka AU - Olejnik-Schmidt A AUID- ORCID: 0000-0002-5418-5632 AD - Department of Food Biotechnology and Microbiology, Poznan University of Life Sciences, Wojska Polskiego 48, 60-627 Poznan, Poland. LA - eng PT - Journal Article PT - Review DEP - 20250103 PL - Switzerland TA - Genes (Basel) JT - Genes JID - 101551097 RN - 0 (Bacteriocins) RN - 0 (Anti-Bacterial Agents) SB - IM MH - *Bacteriocins/genetics MH - *Listeria monocytogenes/genetics/drug effects MH - *Lactobacillales/genetics/metabolism MH - Drug Resistance, Bacterial/genetics MH - Listeriosis/microbiology MH - Anti-Bacterial Agents/pharmacology MH - Food Microbiology MH - Humans PMC - PMC11765107 OTO - NOTNLM OT - Listeria monocytogenes OT - bacteriocins OT - genetic determinants OT - lactic acid bacteria OT - resistance COIS- The authors declare no conflicts of interest. EDAT- 2025/01/25 13:52 MHDA- 2025/01/25 13:53 PMCR- 2025/01/03 CRDT- 2025/01/25 01:12 PHST- 2024/12/10 00:00 [received] PHST- 2024/12/24 00:00 [revised] PHST- 2024/12/29 00:00 [accepted] PHST- 2025/01/25 13:53 [medline] PHST- 2025/01/25 13:52 [pubmed] PHST- 2025/01/25 01:12 [entrez] PHST- 2025/01/03 00:00 [pmc-release] AID - genes16010050 [pii] AID - genes-16-00050 [pii] AID - 10.3390/genes16010050 [doi] PST - epublish SO - Genes (Basel). 2025 Jan 3;16(1):50. doi: 10.3390/genes16010050. PMID- 38305055 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240202 IS - 1089-7682 (Electronic) IS - 1054-1500 (Linking) VI - 34 IP - 2 DP - 2024 Feb 1 TI - Dynamics analysis of helical gear considering de-meshing and reverse impact with EHL lubrication condition. LID - 023103 [pii] LID - 10.1063/5.0186433 [doi] AB - The purpose of this paper was to study the evolution and dynamic characteristics of the helical gear system co-existence response considering the occurrence of de-meshing and reverse impact under lubrication conditions. The double-three tooth alternate meshing model of a helical gear was established, and the time-varying geometric parameters, motion parameters, and load distribution of positive meshing and reverse impact were analyzed, respectively. The variation of oil film parameters and the coupling between oil film stiffness and meshing stiffness of a gear system were studied according to the equivalent lubrication model of a helical gear. Considering the phenomenon that the meshing state changed from positive meshing to de-meshing and reverse impact, the dynamics model was established. The global bifurcation diagram, the attraction domain, the phase portrait, and the Poincaré section were used to analyze the evolution of a coexistence response and dynamic characteristics with helical gear system parameters. CI - © 2024 Author(s). Published under an exclusive license by AIP Publishing. FAU - Mo, Shuai AU - Mo S AUID- ORCID: 0000-0003-3305-004X AD - State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning 530004, China and School of Mechanical Engineering, Guangxi University, Nanning 530004, China. AD - State Key Laboratory of Precision Manufacturing for Extreme Service Performance, Central South University, Changsha 410083, China. AD - State Key Lab of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan 430074, China. AD - National Key Laboratory of Science and Technology on Helicopter Transmission, Nanjing 210016, China. FAU - Zhang, Yingxin AU - Zhang Y AUID- ORCID: 0000-0001-8706-512X AD - State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning 530004, China and School of Mechanical Engineering, Guangxi University, Nanning 530004, China. FAU - Chen, Keren AU - Chen K AUID- ORCID: 0000-0002-1698-5380 AD - State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning 530004, China and School of Mechanical Engineering, Guangxi University, Nanning 530004, China. FAU - Zheng, Yanxiao AU - Zheng Y AUID- ORCID: 0009-0007-2501-4723 AD - State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning 530004, China and School of Mechanical Engineering, Guangxi University, Nanning 530004, China. FAU - Zhang, Wei AU - Zhang W AUID- ORCID: 0000-0003-0210-5642 AD - State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures, Guangxi University, Nanning 530004, China and School of Mechanical Engineering, Guangxi University, Nanning 530004, China. LA - eng PT - Journal Article PL - United States TA - Chaos JT - Chaos (Woodbury, N.Y.) JID - 100971574 SB - IM EDAT- 2024/02/02 06:43 MHDA- 2024/02/02 06:44 CRDT- 2024/02/02 05:31 PHST- 2023/11/06 00:00 [received] PHST- 2024/01/04 00:00 [accepted] PHST- 2024/02/02 06:44 [medline] PHST- 2024/02/02 06:43 [pubmed] PHST- 2024/02/02 05:31 [entrez] AID - 3261514 [pii] AID - 10.1063/5.0186433 [doi] PST - ppublish SO - Chaos. 2024 Feb 1;34(2):023103. doi: 10.1063/5.0186433. PMID- 16500179 OWN - NLM STAT- MEDLINE DCOM- 20060420 LR - 20071115 IS - 0003-9993 (Print) IS - 0003-9993 (Linking) VI - 87 IP - 3 DP - 2006 Mar TI - Grip force regulation during pinch grip lifts under somatosensory guidance: comparison between people with stroke and healthy controls. PG - 418-29 AB - OBJECTIVES: To compare the timing and grip force application in a pinch grip task performed under somatosensory guidance in stroke and matched controls and to identify characteristics of impaired grip force regulation after stroke. DESIGN: Matched-pairs control group. SETTING: University research laboratory. PARTICIPANTS: Forty-five people with stroke who could pick up a pen lid using a pinch grip and actively participated in rehabilitation and 45 adults without neurologic conditions or musculoskeletal or skin impairments affecting the hand, matched for age, sex, and hand dominance. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Timing and magnitude of grip forces applied during pinch grip lift and hold. RESULTS: Prolonged time to grip and lift objects, and excessive grip force prior to commencing the lift occurred in approximately half of the contralesional (involved) hands of people with stroke. Fluctuating irregular forces and reduced adaptation of the grip safety margin were also observed. Excessive safety margins were not predominant after stroke. Extreme slowing and disorganized sequencing of the grip and lifting forces and difficulty maintaining a stable grip characterized severe dysfunction. CONCLUSIONS: Delayed grip formulation and variable grip force application are key characteristics of grip dysfunction after stroke. FAU - Blennerhassett, Jannette M AU - Blennerhassett JM AD - Physiotherapy Department, Austin Health: Royal Talbot Rehabilitation Centre, Kew, Australia. Jannette.Blennerhassett@austin.org.au FAU - Carey, Leeanne M AU - Carey LM FAU - Matyas, Thomas A AU - Matyas TA LA - eng PT - Journal Article PL - United States TA - Arch Phys Med Rehabil JT - Archives of physical medicine and rehabilitation JID - 2985158R SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Case-Control Studies MH - Female MH - Fingers/*physiopathology MH - Form Perception/*physiology MH - Hand Strength/*physiology MH - Humans MH - Male MH - Middle Aged MH - Stroke/*physiopathology MH - Task Performance and Analysis MH - Weight Perception/*physiology MH - Weight-Bearing/physiology EDAT- 2006/02/28 09:00 MHDA- 2006/04/21 09:00 CRDT- 2006/02/28 09:00 PHST- 2005/06/27 00:00 [received] PHST- 2005/11/09 00:00 [accepted] PHST- 2006/02/28 09:00 [pubmed] PHST- 2006/04/21 09:00 [medline] PHST- 2006/02/28 09:00 [entrez] AID - S0003-9993(05)01429-2 [pii] AID - 10.1016/j.apmr.2005.11.018 [doi] PST - ppublish SO - Arch Phys Med Rehabil. 2006 Mar;87(3):418-29. doi: 10.1016/j.apmr.2005.11.018. PMID- 36762653 OWN - NLM STAT- MEDLINE DCOM- 20230306 LR - 20230926 IS - 1473-6551 (Electronic) IS - 1350-7540 (Linking) VI - 36 IP - 2 DP - 2023 Apr 1 TI - Current advances in endovascular treatment. PG - 125-130 LID - 10.1097/WCO.0000000000001142 [doi] AB - PURPOSE OF REVIEW: Endovascular thrombectomy (EVT) is the most beneficial reperfusion therapy for acute ischemic stroke. Currently, much effort is done to promote trials examining EVT efficacy and safety in various conditions not included in the main randomized controlled trials established the superiority of EVT. This review summarizes the current advances of EVT patients' selection and periprocedural management. RECENT FINDINGS: Recent evidence points to beneficial effect of EVT among patients with relatively large ischemic core, premorbid independent nonagenarians and basilar artery occlusion, and suggest that intravenous thrombolysis bridging treatment is associated with better reperfusion rates. Ongoing trials currently examine EVT efficacy and safety in distal vessel occlusions and in large vessel occlusion with low NIHSS. Current evidence also support use of general anaesthesia and avoid postprocedural extremely low or high blood pressure as well as haemodynamic instability. SUMMARY: The field of EVT is rapidly evolving. The results of recent trials have dramatically increased the indications for EVT, with many ongoing trials examining further indications. CI - Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. FAU - Molad, Jeremy AU - Molad J AD - Department of Stroke & Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv. FAU - Honig, Asaf AU - Honig A AD - Department of Neurology, Soroka Medical Center, Beer-Sheva, Israel. LA - eng PT - Journal Article PT - Review DEP - 20230210 PL - England TA - Curr Opin Neurol JT - Current opinion in neurology JID - 9319162 SB - IM MH - Aged, 80 and over MH - Humans MH - *Stroke/surgery MH - *Ischemic Stroke MH - Treatment Outcome MH - *Endovascular Procedures/methods MH - Thrombectomy MH - *Brain Ischemia/surgery EDAT- 2023/02/11 06:00 MHDA- 2023/03/07 06:00 CRDT- 2023/02/10 05:53 PHST- 2023/02/11 06:00 [pubmed] PHST- 2023/03/07 06:00 [medline] PHST- 2023/02/10 05:53 [entrez] AID - 00019052-202304000-00012 [pii] AID - 10.1097/WCO.0000000000001142 [doi] PST - ppublish SO - Curr Opin Neurol. 2023 Apr 1;36(2):125-130. doi: 10.1097/WCO.0000000000001142. Epub 2023 Feb 10. PMID- 25691849 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150218 LR - 20201001 IS - 1598-9100 (Print) IS - 2288-1956 (Electronic) IS - 1598-9100 (Linking) VI - 13 IP - 1 DP - 2015 Jan TI - Anaphylactic shock caused by ingestion of polyethylene glycol. PG - 90-4 LID - 10.5217/ir.2015.13.1.90 [doi] AB - Colonoscopy is the current standard method for evaluation of the colon. The diagnostic accuracy and therapeutic safety of colonoscopy depend on the quality of colonic cleansing and preparation. Generally, all these preparations have been demonstrated to be safe for use in healthy individuals without significant comorbid conditions. Based on safety and efficacy concerns, polyethylene glycol (PEG) is most commonly utilized as a bowel preparation solution for colonoscopy. Adverse events in patients receiving PEG are mostly clinically non-significant. However, fatal adverse events rarely have been shown to occur in the few individuals who experience vomiting or aspiration. Anaphylactic shock associated with ingestion of PEG electrolyte solution is an extremely rare fatal complication, and reported mainly in Western countries. Here, we report the first case of anaphylactic shock following the ingestion of PEG solution in Korea. FAU - Lee, Sun Hee AU - Lee SH AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Cha, Jae Myung AU - Cha JM AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Lee, Joung Il AU - Lee JI AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Joo, Kwang Ro AU - Joo KR AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Shin, Hyun Phil AU - Shin HP AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Baek, Il Hyun AU - Baek IH AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Jeon, Jung Won AU - Jeon JW AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Lim, Jun Uk AU - Lim JU AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Lee, Jung Lok AU - Lee JL AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Lee, Hyae Min AU - Lee HM AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. FAU - Cho, Young-Hak AU - Cho YH AD - Department of Internal Medicine, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, Korea. LA - eng PT - Journal Article DEP - 20150129 PL - Korea (South) TA - Intest Res JT - Intestinal research JID - 101572802 PMC - PMC4316229 OTO - NOTNLM OT - Adverse effects OT - Anaphylaxis OT - Colonoscopy OT - Polyethylene glycols OT - Shock COIS- Conflict of interest: None. EDAT- 2015/02/19 06:00 MHDA- 2015/02/19 06:01 PMCR- 2015/01/01 CRDT- 2015/02/19 06:00 PHST- 2014/04/04 00:00 [received] PHST- 2014/06/18 00:00 [revised] PHST- 2014/07/11 00:00 [accepted] PHST- 2015/02/19 06:00 [entrez] PHST- 2015/02/19 06:00 [pubmed] PHST- 2015/02/19 06:01 [medline] PHST- 2015/01/01 00:00 [pmc-release] AID - 10.5217/ir.2015.13.1.90 [doi] PST - ppublish SO - Intest Res. 2015 Jan;13(1):90-4. doi: 10.5217/ir.2015.13.1.90. Epub 2015 Jan 29. PMID- 21160400 OWN - NLM STAT- MEDLINE DCOM- 20110408 LR - 20220409 IS - 1528-1159 (Electronic) IS - 0362-2436 (Linking) VI - 35 IP - 26 Suppl DP - 2010 Dec 15 TI - Lumbar fusion in octogenarians: the promise of minimally invasive surgery. PG - S355-60 LID - 10.1097/BRS.0b013e3182023796 [doi] AB - STUDY DESIGN: Retrospective chart review of prospectively collected data from 2 nonrandomized, nonconcurrent cohorts. OBJECTIVE: Early results of 2 lumbar interbody fusion procedures-open posterior lumbar interbody fusion (PLIF) and minimally invasive (extreme lateral interbody fusion [XLIF])-were compared in octogenarians to demonstrate the safety of each in the extreme elderly populations. SUMMARY OF BACKGROUND DATA: Although spinal pathologies are common in the elderly patients, additional health conditions often preclude operative treatment because anesthesia, blood loss, and recovery are too demanding. Minimally invasive approaches reduce procedure-related morbidity and recovery time. METHODS: In our single-site prospective series of XLIF patients, 40 were identified as those aged ≥80 years with a minimum of 3-month follow-up. A complete, retrospective review of surgical patients treated in the same practice with traditional open posterior (PLIF) approach found 20 patients aged ≥80 years. Comparisons were made between groups to identify differences in morbidity and mortality rates. RESULTS: No clinically significant differences in demographics, diagnoses, or comorbidities were found between groups. Complication rate, blood loss/transfusion rate, and hospital stay were significantly lower in the minimally invasive surgery (MIS) group (P < 0.0001). MIS patients left the hospital an average of 4 days earlier than the open PLIF patients, most discharged home (92.5% XLIF vs. 0% PLIF) rather than to skilled nursing facilities. Six deaths occurred in the PLIF follow-up, 3 within 3 months postoperatively; there was 1 death at 6 months postoperatively XLIF. CONCLUSION: Surgical treatment need not be withheld on the basis of age; elderly patients can successfully be treated using MIS techniques, and are-in our experience-among the most satisfied with their outcomes, enjoying significant improvements in pain, mobility, and quality of life. FAU - Rodgers, William Blake AU - Rodgers WB AD - Spine Midwest Inc., Jefferson City, MO, USA. jrodgers@spinemidwest.com FAU - Gerber, Edward J AU - Gerber EJ FAU - Rodgers, Jody A AU - Rodgers JA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Spine (Phila Pa 1976) JT - Spine JID - 7610646 SB - IM MH - Aged, 80 and over MH - Humans MH - Lumbar Vertebrae/*surgery MH - Minimally Invasive Surgical Procedures/*methods MH - Prospective Studies MH - Spinal Diseases/*surgery MH - Spinal Fusion/*methods MH - Treatment Outcome EDAT- 2011/01/05 06:00 MHDA- 2011/04/09 06:00 CRDT- 2010/12/17 06:00 PHST- 2010/12/17 06:00 [entrez] PHST- 2011/01/05 06:00 [pubmed] PHST- 2011/04/09 06:00 [medline] AID - 00007632-201012151-00012 [pii] AID - 10.1097/BRS.0b013e3182023796 [doi] PST - ppublish SO - Spine (Phila Pa 1976). 2010 Dec 15;35(26 Suppl):S355-60. doi: 10.1097/BRS.0b013e3182023796. PMID- 11326804 OWN - NLM STAT- MEDLINE DCOM- 20010517 LR - 20221207 IS - 0098-8421 (Print) IS - 0098-8421 (Linking) VI - 56 IP - 2 DP - 2001 Spring TI - Post-traumatic stress disorder in extremely poor women: implications for health care clinicians. PG - 79-85 AB - OBJECTIVES: To identify childhood antecedents for lifetime post-traumatic stress disorder (PTSD) and to determine how this diagnosis relates to health and service use among extremely poor women. METHODS: We conducted a secondary data analysis of 425 women in the Worcester Family Research Project, a case-control longitudinal study of 220 sheltered homeless and 216 extremely poor housed (never homeless) women in Worcester, Massachusetts. RESULTS: We found that extremely poor women with lifetime PTSD were more likely to have grown up in family environments of violence, threat, and anger than those without PTSD. The strongest risk factor for PTSD was childhood sexual abuse with threat. Low-income women with lifetime PTSD had more bodily pain, even when controlling for other health and demographic factors. Women with PTSD experienced more chronic health conditions and had more problematic relationships with their health care providers and perceived more barriers to care. CONCLUSION: Many low-income women have difficulty using medical care appropriately because of childhood histories of physical and sexual abuse, the subsequent development of post-trauma responses, and structural barriers to care. Given these factors, it is critical that health care clinicians routinely screen for histories of violence and PTSD and develop treatment plans that ensure safety, link current symptoms with prior experiences, and provide support as necessary. A team approach coordinated by a case manager may be the best strategy. Without routine screening for PTSD and sensitive treatment, many extremely poor women will receive compromised health care and may even be retraumatized. FAU - Bassuk, E L AU - Bassuk EL AD - Better Homes Fund, 181 Wells Ave, Newton, MA 02459, USA. FAU - Dawson, R AU - Dawson R FAU - Perloff, J AU - Perloff J FAU - Weinreb, L AU - Weinreb L LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - J Am Med Womens Assoc (1972) JT - Journal of the American Medical Women's Association (1972) JID - 7503064 SB - IM MH - Adult MH - Case-Control Studies MH - Delivery of Health Care MH - Female MH - Ill-Housed Persons MH - Humans MH - Longitudinal Studies MH - *Poverty MH - Stress Disorders, Post-Traumatic/*diagnosis MH - United States MH - *Women's Health EDAT- 2001/05/01 10:00 MHDA- 2001/05/18 10:01 CRDT- 2001/05/01 10:00 PHST- 2001/05/01 10:00 [pubmed] PHST- 2001/05/18 10:01 [medline] PHST- 2001/05/01 10:00 [entrez] PST - ppublish SO - J Am Med Womens Assoc (1972). 2001 Spring;56(2):79-85. PMID- 11419660 OWN - NLM STAT- MEDLINE DCOM- 20020416 LR - 20170214 IS - 0267-6591 (Print) IS - 0267-6591 (Linking) VI - 16 IP - 3 DP - 2001 May TI - Veno-venous perfusion-induced systemic hyperthermia: case report with perfusion considerations. PG - 243-8 AB - Cancer cells are more susceptible to destruction by heat than are their normal counterparts. However, optimization of this hyperthermic susceptibility for selective cancer cell kill has been difficult to define and technically difficult to achieve. A whole-body hyperthermic technique veno-venous perfusion-induced systemic hyperthermia (VV-PISH) was designed in in vitro and in swine experiments to achieve selective hyperthermic cancer cell destruction. In this case report, VV-PISH is studied for its safety and therapeutic efficiency in a Food and Drug Administration (FDA) approved phase-I study, where hyperthermia is used to treat advanced (Stage III B or IV) lung cancer. VV-PISH, utilizing the ThermoChem HT system in an extracorporeal circuit, was used to induce hyperthermia to 42.5 degrees C sustained for 120 min. Cooling returned the body temperature to 37 degrees C. After completion of the treatment, the patient was transferred to the intensive care unit on a ventilator, norepinephrine and diuretics. The patient remained somnolent for 36 h, developed pulmonary congestion requiring an additional 48 h before extubation, was transferred to the intermediate unit on day 4 and discharged in good condition on day 8. He did experience hyperthermia-related shrinkage of his lung cancer; however, he succumbed 270 days after this treatment from further progression of this disease. Hyperthermia is not a benign therapy; management techniques have been developed that have ameliorated many of the problems associated with extremely high temperatures, but pathophysiology still exists. Using these techniques, VV-PISH can be safety implemented, albeit not without temporary sequelae and further hospitalization. FAU - Vertrees, R A AU - Vertrees RA AD - Department of Surgery, The University of Texas Medical Branch, Galveston 77555-0528, USA. rvertree@utmb.edu FAU - Zwischenberger, J B AU - Zwischenberger JB FAU - Woodson, L C AU - Woodson LC FAU - Bedell, E A AU - Bedell EA FAU - Deyo, D J AU - Deyo DJ FAU - Chernin, J M AU - Chernin JM LA - eng GR - MO1 RR-00073/RR/NCRR NIH HHS/United States PT - Case Reports PT - Clinical Trial PT - Clinical Trial, Phase I PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - England TA - Perfusion JT - Perfusion JID - 8700166 SB - IM MH - Body Temperature MH - Carcinoma, Non-Small-Cell Lung/complications/therapy MH - Catheterization MH - Extracorporeal Circulation/adverse effects/instrumentation/*methods MH - Fatal Outcome MH - Femoral Vein MH - Humans MH - Hyperthermia, Induced/*methods MH - Jugular Veins MH - Lung Neoplasms/complications/therapy MH - Male MH - Middle Aged MH - Treatment Outcome EDAT- 2001/06/23 10:00 MHDA- 2002/04/17 10:01 CRDT- 2001/06/23 10:00 PHST- 2001/06/23 10:00 [pubmed] PHST- 2002/04/17 10:01 [medline] PHST- 2001/06/23 10:00 [entrez] AID - 10.1177/026765910101600310 [doi] PST - ppublish SO - Perfusion. 2001 May;16(3):243-8. doi: 10.1177/026765910101600310. PMID- 27633650 OWN - NLM STAT- MEDLINE DCOM- 20170418 LR - 20170418 IS - 1600-0536 (Electronic) IS - 0105-1873 (Linking) VI - 75 IP - 5 DP - 2016 Nov TI - Comparative sensitizing potencies of fragrances, preservatives, and hair dyes. PG - 265-275 LID - 10.1111/cod.12683 [doi] AB - The local lymph node assay (LLNA) is used for assessing sensitizing potential in hazard identification and risk assessment for regulatory purposes. Sensitizing potency on the basis of the LLNA is categorized into extreme (EC3 value of ≤0.2%), strong (>0.2% to ≤2%), and moderate (>2%). To compare the sensitizing potencies of fragrance substances, preservatives, and hair dye substances, which are skin sensitizers that frequently come into contact with the skin of consumers and workers, LLNA results and EC3 values for 72 fragrance substances, 25 preservatives and 107 hair dye substances were obtained from two published compilations of LLNA data and opinions by the Scientific Committee on Consumer Safety and its predecessors. The median EC3 values of fragrances (n = 61), preservatives (n = 19) and hair dyes (n = 59) were 5.9%, 0.9%, and 1.3%, respectively. The majority of sensitizing preservatives and hair dyes are thus strong or extreme sensitizers (EC3 value of ≤2%), and fragrances are mostly moderate sensitizers. Although fragrances are typically moderate sensitizers, they are among the most frequent causes of contact allergy. This indicates that factors other than potency need to be addressed more rigorously in risk assessment and risk management. CI - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Lidén, Carola AU - Lidén C AD - Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden. carola.liden@ki.se. FAU - Yazar, Kerem AU - Yazar K AD - Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden. FAU - Johansen, Jeanne D AU - Johansen JD AD - Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, 2900 Hellerup, Denmark. FAU - Karlberg, Ann-Therese AU - Karlberg AT AD - Department of Chemistry and Molecular Biology, Dermatochemistry, University of Gothenburg, 405 30 Gothenburg, Sweden. FAU - Uter, Wolfgang AU - Uter W AUID- ORCID: 0000-0002-4498-3710 AD - Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-University Erlangen/Nürnberg, 91054 Erlangen, Germany. FAU - White, Ian R AU - White IR AD - Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's Hospital, London SE1 9RT, UK. LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - England TA - Contact Dermatitis JT - Contact dermatitis JID - 7604950 RN - 0 (Allergens) RN - 0 (Hair Dyes) RN - 0 (Perfume) RN - 0 (Preservatives, Pharmaceutical) SB - IM MH - Allergens/*toxicity MH - Animals MH - Dermatitis, Allergic Contact/*etiology MH - Disease Models, Animal MH - Dose-Response Relationship, Drug MH - Hair Dyes/*toxicity MH - *Immunization MH - Local Lymph Node Assay MH - Perfume/*toxicity MH - Preservatives, Pharmaceutical/*toxicity MH - Risk Assessment MH - Skin Tests OTO - NOTNLM OT - EC3 value OT - Scientific Committee on Consumer Safety OT - fragrances OT - hair dyes OT - hazard OT - preservatives OT - risk assessment EDAT- 2016/09/17 06:00 MHDA- 2017/04/19 06:00 CRDT- 2016/09/17 06:00 PHST- 2016/07/07 00:00 [received] PHST- 2016/07/31 00:00 [revised] PHST- 2016/08/03 00:00 [accepted] PHST- 2016/09/17 06:00 [pubmed] PHST- 2017/04/19 06:00 [medline] PHST- 2016/09/17 06:00 [entrez] AID - 10.1111/cod.12683 [doi] PST - ppublish SO - Contact Dermatitis. 2016 Nov;75(5):265-275. doi: 10.1111/cod.12683. PMID- 9748718 OWN - NLM STAT- MEDLINE DCOM- 19981109 LR - 20131121 IS - 0004-4172 (Print) IS - 0004-4172 (Linking) VI - 48 IP - 8 DP - 1998 Aug TI - Appropriate mammalian expression systems for biopharmaceuticals. PG - 870-80 AB - Process development for biopharmaceuticals is dictated by product quality, drug safety and economy of the manufacturing process. Not surprisingly, these factors also play a key role in the evaluation of mammalian cell expression systems to be used in the production of pharmacologically active glycoproteins. To date, the most prominent candidates for efficient expression of glycoproteins are mammalian cell lines such as mouse fibroblast cells (C 127-BPV), Chinese hamster ovary cells (CHO-DHFR, CHO-NEOSPLA, CHO-GS), mouse myeloma cells (NSO-GS) as well as transgenic animals carrying c-DNA or genomic DNA which codes for the protein of interest. The expression titer in the case of glycoproteins is mainly determined by the promoter construct, the site of integration into the chromosome, the copy number and the type of protein in question. Based on expression titer, CHO-NEOSPLA and NSO-GS expression systems are most effective in the production of monoclonal antibodies and, to a lesser extent, of recombinant DNA derived proteins. However, based on overall product yield, expression of recombinant DNA derived proteins in transgenic animals is by far the most promising system. Therefore, for proteins required in large quantities, transgenic expression systems offer an attractive choice. However, cost of goods for products for which the dosage or the overall annual quantities are low, is dominated by downstream processing, filling, lyophilization and packaging and not by the fermentation process. Such proteins are preferentially produced by classical mammalian cell culture systems. Concerns which have to be addressed with respect to drug safety in the transgenic animal approach are the size of the herd, genetic stability from animal to animal, variation in productivity and in impurity profiles during lactation periods, microbial, viral, mycoplasma and prion contaminants, the dependence on health status and the life span of the animal. In a number of cases glycosylation of the protein is relevant for the prevention of immunogenicity of the protein, the pharmacological activity, the pharmacokinetic profile, solubility and stability against proteolysis. The glycosylation pattern, depending on protein structure, is influenced by the enzymatic system of the host cell as well as by fermentation conditions. Therefore, selection of host cells and culture conditions must take into account the requirement for a specific and stable glycosylation pattern. For the assessment of glycovariants, a number of protein analytical methods such as peptide mapping, isoelectric focusing, oligosaccharide mapping, MALDI-TOF (matrix assisted laser desorption mass spectrometry-time of flight), capillary electrophoresis and specific potency assays are available. In our experiments, glycosylation of proteins expressed in CHO cells was demonstrated to be very stable. Only extreme process times, cultivation methods and ammonium ion concentrations had an influence on the glycosylation profile. Among the three products investigated--tissue plasminogen activator (t-PA), interferon omega and soluble intercellular adhesion molecule (s-ICAM)--t-PA expressed the most stable glycosylation pattern. Only at extreme ammonium concentrations an increase of mannose-5 structures was observed, whereas biantennary complex structures were reduced. On the other hand, interferon omega and s-ICAM showed greater susceptibility to increased ammonium concentrations and to adherent cultivation. Such conditions induced quantitative changes to the glycosylation pattern favoring the appearance of higher branched structures. Short cultivation times resulted in more heterogenous oligosaccharide structures. Since the glycosylation of the three proteins is different in the same host cell, the amino acid sequence of the protein apparently influences the glycosylation pattern and its sensitivity to culture conditions. In NSO-mouse myeloma cells, production of s-ICAM is two times as high as in CHO cells FAU - Werner, R G AU - Werner RG AD - Boehringer Ingelheim Pharma KG, Biberach an der Riss, Germany. FAU - Noé, W AU - Noé W FAU - Kopp, K AU - Kopp K FAU - Schlüter, M AU - Schlüter M LA - eng PT - Journal Article PT - Review PL - Germany TA - Arzneimittelforschung JT - Arzneimittel-Forschung JID - 0372660 RN - 0 (Biological Products) SB - IM MH - Animals MH - Animals, Genetically Modified MH - Base Sequence MH - Biological Products/*biosynthesis MH - Cells, Cultured MH - Cricetinae MH - Genetic Vectors MH - Humans MH - Mammals/*metabolism MH - Mice MH - Molecular Sequence Data MH - Rats RF - 28 EDAT- 1998/09/28 00:00 MHDA- 1998/09/28 00:01 CRDT- 1998/09/28 00:00 PHST- 1998/09/28 00:00 [pubmed] PHST- 1998/09/28 00:01 [medline] PHST- 1998/09/28 00:00 [entrez] PST - ppublish SO - Arzneimittelforschung. 1998 Aug;48(8):870-80. PMID- 30632277 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) VI - 15 IP - 6 DP - 2019 Feb TI - Component-Interaction Reinforced Quasi-Solid Electrolyte with Multifunctionality for Flexible Li-O(2) Battery with Superior Safety under Extreme Conditions. PG - e1804701 LID - 10.1002/smll.201804701 [doi] AB - High-performance flexible lithium-oxygen (Li-O(2) ) batteries with excellent safety and stability are urgently required due to the rapid development of flexible and wearable devices. Herein, based on an integrated solid-state design by taking advantage of component-interaction between poly(vinylidene fluoride-co-hexafluoropropylene) and nanofumed silica in polymer matrix, a stable quasi-solid-state electrolyte (PS-QSE) for the Li-O(2) battery is proposed. The as-assembled Li-O(2) battery containing the PS-QSE exhibits effectively improved anodic reversibility (over 200 cycles, 850 h) and cycling stability of the battery (89 cycles, nearly 900 h). The improvement is attributed to the stability of the PS-QSE (including electrochemical, chemical, and mechanical stability), as well as the effective protection of lithium anode from aggressive soluble intermediates generated in cathode. Furthermore, it is demonstrated that the interaction among the components plays a pivotal role in modulating the Li-ion conducting mechanism in the as-prepared PS-QSE. Moreover, the pouch-type PS-QSE based Li-O(2) battery also shows wonderful flexibility, tolerating various deformations thanks to its integrated solid-state design. Furthermore, holes can be punched through the Li-O(2) battery, and it can even be cut into any desired shape, demonstrating exceptional safety. Thus, this type of battery has the potential to meet the demands of tailorability and comformability in flexible and wearable electronics. CI - © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Shu, Chaozhu AU - Shu C AD - College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Dongsanlu, Erxianqiao, Chengdu, 610059, Sichuan, P. R. China. AD - Institute for Superconducting and Electronic Materials, University of Wollongong, Squires Way, North Wollongong, NSW, 2500, Australia. FAU - Long, Jianping AU - Long J AD - College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Dongsanlu, Erxianqiao, Chengdu, 610059, Sichuan, P. R. China. FAU - Dou, Shi-Xue AU - Dou SX AD - Institute for Superconducting and Electronic Materials, University of Wollongong, Squires Way, North Wollongong, NSW, 2500, Australia. FAU - Wang, Jiazhao AU - Wang J AUID- ORCID: 0000-0002-1407-2166 AD - Institute for Superconducting and Electronic Materials, University of Wollongong, Squires Way, North Wollongong, NSW, 2500, Australia. LA - eng GR - DP140100401/Australian Research Council/ GR - KYGG201709/Chengdu University of Technology/ PT - Journal Article DEP - 20190111 PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 OTO - NOTNLM OT - Li dendrites OT - Li-O2 batteries OT - composite polymer electrolytes OT - flexible OT - super structure stability EDAT- 2019/01/12 06:00 MHDA- 2019/01/12 06:01 CRDT- 2019/01/12 06:00 PHST- 2018/11/09 00:00 [received] PHST- 2018/11/30 00:00 [revised] PHST- 2019/01/12 06:00 [pubmed] PHST- 2019/01/12 06:01 [medline] PHST- 2019/01/12 06:00 [entrez] AID - 10.1002/smll.201804701 [doi] PST - ppublish SO - Small. 2019 Feb;15(6):e1804701. doi: 10.1002/smll.201804701. Epub 2019 Jan 11. PMID- 31835808 OWN - NLM STAT- MEDLINE DCOM- 20200505 LR - 20200505 IS - 1420-3049 (Electronic) IS - 1420-3049 (Linking) VI - 24 IP - 24 DP - 2019 Dec 11 TI - Nano-(Q)SAR for Cytotoxicity Prediction of Engineered Nanomaterials. LID - 10.3390/molecules24244537 [doi] LID - 4537 AB - Although nanotechnology is a new and rapidly growing area of science, the impact of nanomaterials on living organisms is unknown in many aspects. In this regard, it is extremely important to perform toxicological tests, but complete characterization of all varying preparations is extremely laborious. The computational technique called quantitative structure-activity relationship, or QSAR, allows reducing the cost of time- and resource-consuming nanotoxicity tests. In this review, (Q)SAR cytotoxicity studies of the past decade are systematically considered. We regard here five classes of engineered nanomaterials (ENMs): Metal oxides, metal-containing nanoparticles, multi-walled carbon nanotubes, fullerenes, and silica nanoparticles. Some studies reveal that QSAR models are better than classification SAR models, while other reports conclude that SAR is more precise than QSAR. The quasi-QSAR method appears to be the most promising tool, as it allows accurately taking experimental conditions into account. However, experimental artifacts are a major concern in this case. FAU - Buglak, Andrey A AU - Buglak AA AD - A. N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia. AD - Physical faculty, St. Petersburg State University, 7/9 Universitetskaya naberezhnaya, 199034 St. Petersburg, Russia. FAU - Zherdev, Anatoly V AU - Zherdev AV AD - A. N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia. AD - Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severny proezd 1, 142432 Chernogolovka, Moscow Region, Russia. FAU - Dzantiev, Boris B AU - Dzantiev BB AD - A. N. Bach Institute of Biochemistry, Research Center of Biotechnology, Russian Academy of Sciences, Leninsky Prospect 33, 119071 Moscow, Russia. LA - eng GR - 14.613.21.0086 (unique identifier of the project: RFMEFI61318X0086)/Ministry of Science and High Education of the Russian Federation/ PT - Journal Article PT - Review DEP - 20191211 PL - Switzerland TA - Molecules JT - Molecules (Basel, Switzerland) JID - 100964009 SB - IM MH - Animals MH - Computer Simulation MH - Humans MH - Models, Molecular MH - Nanostructures/*toxicity MH - Quantitative Structure-Activity Relationship MH - Toxicity Tests PMC - PMC6943593 OTO - NOTNLM OT - descriptors OT - engineered nanomaterials OT - modeling OT - quasi-QSAR OT - safety of nanomaterials OT - toxicological tests COIS- The authors declare no conflicts of interests. EDAT- 2019/12/15 06:00 MHDA- 2020/05/06 06:00 PMCR- 2019/12/11 CRDT- 2019/12/15 06:00 PHST- 2019/10/30 00:00 [received] PHST- 2019/11/24 00:00 [revised] PHST- 2019/12/10 00:00 [accepted] PHST- 2019/12/15 06:00 [entrez] PHST- 2019/12/15 06:00 [pubmed] PHST- 2020/05/06 06:00 [medline] PHST- 2019/12/11 00:00 [pmc-release] AID - molecules24244537 [pii] AID - molecules-24-04537 [pii] AID - 10.3390/molecules24244537 [doi] PST - epublish SO - Molecules. 2019 Dec 11;24(24):4537. doi: 10.3390/molecules24244537. PMID- 33155961 OWN - NLM STAT- MEDLINE DCOM- 20201110 LR - 20201110 IS - 0022-9040 (Print) IS - 0022-9040 (Linking) VI - 60 IP - 8 DP - 2020 Sep 17 TI - [Experience of the use of the PCSK9 inhibitor Alirocumab in patients with extremely high cardiovascular risk]. PG - 71-77 LID - 10.18087/cardio.2020.8.n1046 [doi] AB - Aim To study the efficacy and safety of alirocumab in patients with high and very high cardiovascular risk in the Republic of Karelia and to evaluate their compliance with the alirocumab therapy.Materials and methods Study design: observational, noncomparative. The observation group consisted of 9 patients receiving alirocumab (Praluent®) (mean age, 48.6±4.7 years; 7 men). 7 patients had familial hypercholesterolemia of the type diagnosed by DLCN criteria; five patients had MI. Lipid profile, concentrations of transaminases, creatinine, glucose, and lipoprotein a (LP(a)) were measured at 3, 6, 12, and 18 months. Electrocardiography was performed, and the clinical picture (development of acute coronary syndrome, acute cerebrovascular disease, transient ischemic attacks, myocardial revascularization, and cardiovascular death) was evaluated. Efficacy criteria included the absence of these clinical conditions, the proportion of patients who achieved the LDL CS goal, and the decrease in LP(a). Safety was evaluated by clinical and laboratory data, such as levels of transaminases, total bilirubin, creatinine, and blood glucose. The observation lasted for 6 months to 1.5 years.Results LDL CS goals were achieved in 7 (77.8%) patients receiving alirocumab. The mean level of LP(a) decreased from 0.39 to 0.28 g/l; the degree of decrease ranged from 20 to 33 %. No cases of IHD instability (acute coronary syndrome) or new cases of acute cerebrovascular disease and transient ischemic attacks were observed. None of the patients had to stop the alirocumab treatment; adverse effects, including local ones, were not observed.Conclusion LDL CS goals were achieved in 7 (77.8%) patients. The level of LP(a) decreased by 20-33% in patients receiving the PCSK9 inhibitor. In real-life clinical practice, the alirocumab treatment was characterized with high compliance and good tolerability without side effects, including local ones. FAU - Korneva, V A AU - Korneva VA AD - Petrozavodsk State University, Russia. FAU - Kuznetsova, T Yu AU - Kuznetsova TY AD - Petrozavodsk State University, Russia. FAU - Scopetc, I S AU - Scopetc IS AD - Petrozavodsk State University, Russia. FAU - Vezikova, N N AU - Vezikova NN AD - Petrozavodsk State University, Russia. LA - rus PT - Journal Article DEP - 20200917 PL - Russia (Federation) TA - Kardiologiia JT - Kardiologiia JID - 0376351 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 0 (Anticholesteremic Agents) RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) RN - EC 3.4.21.- (PCSK9 protein, human) RN - EC 3.4.21.- (Proprotein Convertase 9) RN - PP0SHH6V16 (alirocumab) SB - IM MH - Adult MH - Antibodies, Monoclonal, Humanized MH - *Anticholesteremic Agents/adverse effects MH - *Cardiovascular Diseases/prevention & control MH - Humans MH - *Hydroxymethylglutaryl-CoA Reductase Inhibitors MH - *Hypercholesterolemia MH - Male MH - Middle Aged MH - Proprotein Convertase 9 MH - Risk Factors MH - Treatment Outcome EDAT- 2020/11/07 06:00 MHDA- 2020/11/11 06:00 CRDT- 2020/11/06 12:11 PHST- 2020/02/15 00:00 [received] PHST- 2020/05/22 00:00 [accepted] PHST- 2020/11/06 12:11 [entrez] PHST- 2020/11/07 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] AID - 10.18087/cardio.2020.8.n1046 [doi] PST - epublish SO - Kardiologiia. 2020 Sep 17;60(8):71-77. doi: 10.18087/cardio.2020.8.n1046. PMID- 39076496 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240731 IS - 2153-8174 (Electronic) IS - 2153-8174 (Print) IS - 1530-6550 (Linking) VI - 25 IP - 5 DP - 2024 May TI - Needle-free, Novel Fossa Ovalis Puncture with Percutaneous Transluminal Coronary Angioplasty Guidewire and Microcatheter in Pigs and a Human with an Extremely Tortuous Inferior Vena Cava. PG - 170 LID - 10.31083/j.rcm2505170 [doi] LID - 170 AB - BACKGROUND: Transseptal puncture (TSP) performed with the Brockenbrough (BRK) needle is technically demanding and carries potential risks. The back end of the percutaneous transluminal coronary angioplasty (PTCA) guidewire is blunt and flexible, with good support, it can puncture the right ventricle-free wall, which is thicker than the atrial-septum. The guidewire is thin and easy to manipulate. This study evaluated the performance of TSP with a PTCA guidewire and microcatheter without a needle. METHODS: The back end of a PTCA guidewire was advanced into the Tiger (TIG) catheter, within the SL1 sheath, to puncture the fossa ovalis (FO) under fluoroscopy. Subsequently, the microcatheter was inserted into the left atrium (LA) above the guidewire, and the front end of the guidewire was exchanged in the LA. After the puncture site was confirmed by contrast, the TIG catheter and a 0.032 inch wire were advanced into the LA. Finally, the sheath, with the dilator, was advanced over the wire into the LA. The safety margin of this method was tested in a pig model. RESULTS: The puncture was successful in all seven pigs tested with a puncture-to-sheath entry time of  <  20 minutes and no procedure-related complications. The method was successfully used to perform a difficult TSP in a patient with an extremely tortuous inferior vena cava, in whom puncture with a BRK needle had repeatedly failed. CONCLUSIONS: Cardiologists may use the PTCA guidewire and microcatheter as an alternative to the needle while performing TSP in special conditions, such as an extremely tortuous inferior vena cava. CI - Copyright: © 2024 The Author(s). Published by IMR Press. FAU - Wang, Guang-Xia AU - Wang GX AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. FAU - Luo, Hong AU - Luo H AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. FAU - Jia, Feng-Peng AU - Jia FP AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. FAU - Li, Run-Tu AU - Li RT AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. FAU - He, Quan AU - He Q AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. FAU - Qin, Chun-Chang AU - Qin CC AD - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, 400017 Chongqing, China. LA - eng PT - Journal Article DEP - 20240514 PL - Singapore TA - Rev Cardiovasc Med JT - Reviews in cardiovascular medicine JID - 100960007 PMC - PMC11267186 OTO - NOTNLM OT - fossa ovalis OT - microcatheter OT - needle-free OT - percutaneous transluminal coronary angioplasty guidewire OT - transseptal puncture COIS- The authors declare no conflict of interest. EDAT- 2024/07/30 06:42 MHDA- 2024/07/30 06:43 PMCR- 2024/05/14 CRDT- 2024/07/30 04:57 PHST- 2023/11/28 00:00 [received] PHST- 2024/01/04 00:00 [revised] PHST- 2024/01/26 00:00 [accepted] PHST- 2024/07/30 06:43 [medline] PHST- 2024/07/30 06:42 [pubmed] PHST- 2024/07/30 04:57 [entrez] PHST- 2024/05/14 00:00 [pmc-release] AID - S1530-6550(24)01327-9 [pii] AID - 10.31083/j.rcm2505170 [doi] PST - epublish SO - Rev Cardiovasc Med. 2024 May 14;25(5):170. doi: 10.31083/j.rcm2505170. eCollection 2024 May. PMID- 32436281 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20210818 IS - 1752-699X (Electronic) IS - 1752-6981 (Linking) VI - 14 IP - 9 DP - 2020 Sep TI - Application of autologous SOX9(+) airway basal cells in patients with bronchiectasis. PG - 839-848 LID - 10.1111/crj.13216 [doi] AB - INTRODUCTION: Bronchiectasis is a common condition and a leading cause of respiratory morbidity and mortality. The treatment method for bronchiectasis is mainly symptomatic treatment or surgery; however, this condition is extremely prone to recurrence. OBJECTIVES: To preliminarily evaluate the safety and efficacy of applying SOX9(+) autologous airway basal cells (BCs) in patients with bronchiectasis. METHODS: SOX9(+) BCs were isolated from microscale tissue of a grade 3-5 bronchus by bronchoscopic brushing and expanded in vitro for approximately 4 weeks. Subsequently, the autologous SOX9(+) BCs were transplanted into the diseased bronchus to treat patients with bronchiectasis. RESULTS: The forced expiratory volume in1 second (FEV1)%, forced vital capacity (FVC)%, total lung capacity (TLC)%, residual volume (RV)% and RV/TLC ratio of predicted value in patients with bronchiectasis were improved at 4, 12, 24 and 48 weeks after cell transplantation, although the differences were not statistically significant (P > .05). Chest CT scans showed that the lesions in the pulmonary segment had not progressed at 4, 12 and 24 weeks after transplantation. No patients died during the follow-up. At 4, 12 and 24 weeks after transplantation, routine blood tests, liver function tests, renal function tests and myocardial enzymatic indexes were normal (P > .05). CONCLUSION: Transplantation of autologous SOX9(+) BCs has positive effects and is safe for patients with bronchiectasis. CI - © 2020 John Wiley & Sons Ltd. FAU - Sun, Fengjun AU - Sun F AUID- ORCID: 0000-0003-2679-8797 AD - Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Cheng, Lin AU - Cheng L AD - Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Guo, Haiqing AU - Guo H AD - Department of Respiratory Disease, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Sun, Yufen AU - Sun Y AD - Regend Therapeutics Co. Ltd, Zhejiang, China. FAU - Ma, Yu AU - Ma Y AD - Regend Therapeutics Co. Ltd, Zhejiang, China. FAU - Wang, Yu AU - Wang Y AD - Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Feng, Wei AU - Feng W AD - Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Yuan, Qian AU - Yuan Q AD - Department of Pharmacy, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. FAU - Dai, Xiaotian AU - Dai X AD - Department of Respiratory Disease, the First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing, China. LA - eng GR - SWH2016LCYB-16/the Clinical Research Fund of the First Affiliated Hospital of Third Military Medical University/ PT - Journal Article DEP - 20200708 PL - England TA - Clin Respir J JT - The clinical respiratory journal JID - 101315570 RN - 0 (SOX9 Transcription Factor) RN - 0 (SOX9 protein, human) SB - IM MH - *Bronchiectasis/diagnostic imaging MH - Forced Expiratory Volume MH - Humans MH - Respiratory Function Tests MH - SOX9 Transcription Factor MH - Total Lung Capacity MH - Vital Capacity OTO - NOTNLM OT - airway basal cells OT - bronchiectasis OT - cell transplantation OT - lung OT - stem cell EDAT- 2020/05/22 06:00 MHDA- 2021/08/19 06:00 CRDT- 2020/05/22 06:00 PHST- 2019/04/01 00:00 [received] PHST- 2020/04/30 00:00 [revised] PHST- 2020/05/12 00:00 [accepted] PHST- 2020/05/22 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2020/05/22 06:00 [entrez] AID - 10.1111/crj.13216 [doi] PST - ppublish SO - Clin Respir J. 2020 Sep;14(9):839-848. doi: 10.1111/crj.13216. Epub 2020 Jul 8. PMID- 33676689 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1873-3573 (Electronic) IS - 0039-9140 (Linking) VI - 226 DP - 2021 May 1 TI - Rapid, sensitive and label-free detection of pathogenic bacteria using a bacteria-imprinted conducting polymer film-based electrochemical sensor. PG - 122135 LID - S0039-9140(21)00056-4 [pii] LID - 10.1016/j.talanta.2021.122135 [doi] AB - The rapid and sensitive detection of pathogenic bacteria is very important for timely prevention and treatment of foodborne disease. Here, a bacteria-imprinted conductive poly(3-thiopheneacetic acid) (BICP) film-based impedimetric sensor was developed for the rapid, sensitive and label-free detection of staphylococcus aureus (S. aureus). The BICP film preparation was very convenient and eco-friendly, which was in situ deposited on gold electrode surface without the use of toxic organic solvents and cross-linkers. The process of imprinting and recognition were characterized by electrochemical technique and scanning electron microscope. The BICP had a novel structure without cocci-shaped cavities formed in the poly(3-thiopheneacetic acid) (PTAA) matrices. To obtain the optimal sensing performance, a set of factors affecting the imprinting and recognition were investigated. Under the optimized conditions, an extremely rapid recognition within 10 min, a very low limit of detection (LOD) of 2 CFU/mL, and wide linear range from 10 to 10(8) CFU/mL were achieved by the BICP film-based impedimetric sensor. The sensor also demonstrated high selectivity, and good universality and repeatability. Furthermore, the feasibility of its application has also been demonstrated in the analysis of real milk samples. This sensor offered a simple and universal method for rapid, sensitive, and selective detection of pathogenic bacteria, which could hold great potentials in fields like food safety. CI - Copyright © 2021 Elsevier B.V. All rights reserved. FAU - Wang, Ruinan AU - Wang R AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. FAU - Wang, Lingling AU - Wang L AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. FAU - Yan, Juan AU - Yan J AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. FAU - Luan, Donglei AU - Luan D AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. FAU - Tao Sun AU - Tao Sun AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. FAU - Wu, Jikui AU - Wu J AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China. Electronic address: jkwu@shou.edu.cn. FAU - Bian, Xiaojun AU - Bian X AD - College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai, 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai, 201306, China. Electronic address: xjbian@shou.edu.cn. LA - eng PT - Journal Article DEP - 20210122 PL - Netherlands TA - Talanta JT - Talanta JID - 2984816R RN - 0 (Polymers) SB - IM MH - Electrochemical Techniques MH - Electrodes MH - Limit of Detection MH - *Molecular Imprinting MH - *Polymers MH - Staphylococcus aureus OTO - NOTNLM OT - Bacteria imprinting OT - Conductive polymer OT - Electrochemical sensor OT - Label-free OT - Molecularly imprinted polymer OT - Thiophene EDAT- 2021/03/08 06:00 MHDA- 2021/05/15 06:00 CRDT- 2021/03/07 20:27 PHST- 2020/10/23 00:00 [received] PHST- 2021/01/12 00:00 [revised] PHST- 2021/01/16 00:00 [accepted] PHST- 2021/03/07 20:27 [entrez] PHST- 2021/03/08 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] AID - S0039-9140(21)00056-4 [pii] AID - 10.1016/j.talanta.2021.122135 [doi] PST - ppublish SO - Talanta. 2021 May 1;226:122135. doi: 10.1016/j.talanta.2021.122135. Epub 2021 Jan 22. PMID- 36437882 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221129 IS - 2296-9144 (Electronic) IS - 2296-9144 (Linking) VI - 9 DP - 2022 TI - Soft robotics for infrastructure protection. PG - 1026891 LID - 10.3389/frobt.2022.1026891 [doi] LID - 1026891 AB - The paradigm change introduced by soft robotics is going to dramatically push forward the abilities of autonomous systems in the next future, enabling their applications in extremely challenging scenarios. The ability of soft robots to safely interact and adapt to the surroundings is key to operate in unstructured environments, where the autonomous agent has little or no knowledge about the world around it. A similar context occurs when critical infrastructures face threats or disruptions, for examples due to natural disasters or external attacks (physical or cyber). In this case, autonomous systems may be employed to respond to such emergencies and have to be able to deal with unforeseen physical conditions and uncertainties, where the mechanical interaction with the environment is not only inevitable but also desirable to successfully perform their tasks. In this perspective, I discuss applications of soft robots for the protection of infrastructures, including recent advances in pipelines inspection, rubble search and rescue, and soft aerial manipulation, and promising perspectives on operations in radioactive environments, underwater monitoring and space exploration. CI - Copyright © 2022 Milana. FAU - Milana, Edoardo AU - Milana E AD - Institute for the Protection of Terrestrial Infrastructures, German Aerospace Center (DLR), Sankt Augustin, Germany. LA - eng PT - Journal Article DEP - 20221110 PL - Switzerland TA - Front Robot AI JT - Frontiers in robotics and AI JID - 101749350 PMC - PMC9684207 OTO - NOTNLM OT - infrastructures protection OT - pipelines inspection OT - rubble search and rescue OT - safety and security OT - soft aerial manipulation OT - soft robotics COIS- The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/11/29 06:00 MHDA- 2022/11/29 06:01 PMCR- 2022/11/10 CRDT- 2022/11/28 04:06 PHST- 2022/08/24 00:00 [received] PHST- 2022/10/26 00:00 [accepted] PHST- 2022/11/28 04:06 [entrez] PHST- 2022/11/29 06:00 [pubmed] PHST- 2022/11/29 06:01 [medline] PHST- 2022/11/10 00:00 [pmc-release] AID - 1026891 [pii] AID - 10.3389/frobt.2022.1026891 [doi] PST - epublish SO - Front Robot AI. 2022 Nov 10;9:1026891. doi: 10.3389/frobt.2022.1026891. eCollection 2022. PMID- 35265572 OWN - NLM STAT- MEDLINE DCOM- 20220428 LR - 20230917 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 10 DP - 2022 TI - Heat Adaptive Capacity: What Causes the Differences Between Residents of Xiamen Island and Other Areas? PG - 799365 LID - 10.3389/fpubh.2022.799365 [doi] LID - 799365 AB - Extreme heat events caused by climate change have serious adverse effects on residents' health in many coastal metropolises in southeast China. Adaptive capacity (AC) is crucial to reduce heat vulnerability in the human-environment system. However, it is unclear whether changes in individual characteristics and socioeconomic conditions likely amplify or attenuate the impacts of residents' heat adaptive capacity (HAC) changes. Moreover, which public policies can be implemented by the authorities to improve the HAC of vulnerable groups remains unknown. We conducted a questionnaire survey of 630 residents of Xiamen, a typical coastal metropolis, in 2018. The effects of individual and household characteristics, and government actions on the residents' HAC were examined by using ordinal logistic regression analysis. Results show that the majority (48.10%) of Xiamen residents had a "medium" HAC level, followed by a "high" level (37.14%). On Xiamen Island, residents who settled locally for one-three years and spent less than one hour outdoors might report weaker HAC, and their HAC would not improve with increased air conditioning units in household. In other areas of Xiamen, residents with more rooms in their households, no educational experience, and building areas <50 m(2) might report better HAC. Further, vulnerable groups, such as local residents and outdoor workers on Xiamen Island, people lacking educational experience and renters in other areas of Xiamen, showed better AC to hot weather than those in previous studies. Low-income groups should be given more attention by local governments and community groups as monthly household income played a positive role in improving Xiamen residents' HAC. Rational green spaces planning and cooling services, such as street sprinkling operations, provided by municipal departments can effectively bring benefits to Xiamen residents. Identification of basic conditions of AC has significant implications for practical promoting targeted measures or policies to reduce health damages and livelihood losses of urban residents during extreme heat events. CI - Copyright © 2022 Wu, Shui, Yang, Ma, Zhu, Liu, Li, Wu, Wu and Sun. FAU - Wu, Chaowei AU - Wu C AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Shui, Wei AU - Shui W AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Yang, Haifeng AU - Yang H AD - Center for Urban Security Development Research, College of Architecture and City Planning, Nanjing University, Nanjing, China. FAU - Ma, Meiqi AU - Ma M AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Zhu, Sufeng AU - Zhu S AD - Chinese Research Academy of Environmental Science, Beijing, China. FAU - Liu, Yuanmeng AU - Liu Y AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Li, Hui AU - Li H AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Wu, Furong AU - Wu F AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Wu, Kexin AU - Wu K AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Sun, Xiang AU - Sun X AD - Department of Geography and Planning, College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220221 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - China/epidemiology MH - *Climate Change MH - *Hot Temperature MH - Humans MH - Poverty PMC - PMC8899036 OTO - NOTNLM OT - China OT - Xiamen Island OT - adaptive capacity OT - climate change OT - extreme heat events OT - heat vulnerability OT - human-environment system COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/03/11 06:00 MHDA- 2022/04/29 06:00 PMCR- 2022/02/21 CRDT- 2022/03/10 05:45 PHST- 2021/10/21 00:00 [received] PHST- 2022/01/24 00:00 [accepted] PHST- 2022/03/10 05:45 [entrez] PHST- 2022/03/11 06:00 [pubmed] PHST- 2022/04/29 06:00 [medline] PHST- 2022/02/21 00:00 [pmc-release] AID - 10.3389/fpubh.2022.799365 [doi] PST - epublish SO - Front Public Health. 2022 Feb 21;10:799365. doi: 10.3389/fpubh.2022.799365. eCollection 2022. PMID- 15085723 OWN - NLM STAT- MEDLINE DCOM- 20040521 LR - 20181130 IS - 0035-9351 (Print) IS - 0035-9351 (Linking) VI - 83 IP - 2 DP - 2004 Feb TI - [The 7th Field Hospital of the Army of the Czech Republic (ACR) in southern Iraq: statistics of professional activity and aspects of a foreign mission]. PG - 85-9 AB - The short communication informs about the work of the field hospital in Iraq. From 3rd June till 10th September 2003 there were 123 patients operated on, 184 patients were hospitalized. The hospital exerted 1,194 bed-days, 131 of them at the intensive care unit. The outpatient department treated 6,953 patients. There were 824 X-ray and ultrasonographic examinations and the laboratory performed 7,941 tests. In their practice the physicians encountered a wide spectrum of surgical and non-surgical diagnoses. Other humanitarian activities (material, organization of transport of children to specialized care in the Czech Republic, blood donor activity) were an integral part of the work. The work in non-standard conditions was significantly complicated by the extreme climate and the high safety risk. FAU - Chmátal, P AU - Chmátal P AD - 7. polní nemocnice Al Basrah-Irák. FAU - Karnos, V AU - Karnos V FAU - Sanda, V AU - Sanda V FAU - Hasek, R AU - Hasek R FAU - Bohonĕk, M AU - Bohonĕk M FAU - Cernohous, M AU - Cernohous M FAU - Ondrásek, O AU - Ondrásek O LA - cze PT - Journal Article TT - 7. polní nemocnice ACR v jizním Iráku: statistika odborné práce, aspekty zahranicní mise. PL - Czech Republic TA - Rozhl Chir JT - Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti JID - 9815441 SB - IM MH - Czech Republic MH - General Surgery/statistics & numerical data MH - Hospitals, Military/*statistics & numerical data MH - Humans MH - Iraq MH - Medical Missions MH - Warfare MH - Wounds and Injuries/therapy EDAT- 2004/04/17 05:00 MHDA- 2004/05/22 05:00 CRDT- 2004/04/17 05:00 PHST- 2004/04/17 05:00 [pubmed] PHST- 2004/05/22 05:00 [medline] PHST- 2004/04/17 05:00 [entrez] PST - ppublish SO - Rozhl Chir. 2004 Feb;83(2):85-9. PMID- 36136814 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220924 IS - 2409-9279 (Electronic) IS - 2409-9279 (Linking) VI - 5 IP - 5 DP - 2022 Aug 30 TI - In Vitro Screening Method for Characterization of Macrophage Activation Responses. LID - 10.3390/mps5050068 [doi] LID - 68 AB - Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage surfaces, the nature of activation (or acquired functioning) can be specific to the encountering stimulus. This article describes a macrophage-activation screening platform in a 96-well format. The methodology involves the generation of bone marrow-derived macrophages, their activation into two extreme activation states, and screening of activated macrophages for expression of bonafide protein biomarkers. A high-throughput and stringent assay to determine macrophage activation markers developed in this article can be adapted for biomarker determination in pathological conditions and toxicant/drug safety screening. FAU - Lewis, Brandon W AU - Lewis BW AD - Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. FAU - Patial, Sonika AU - Patial S AUID- ORCID: 0000-0002-7373-0835 AD - Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. FAU - Saini, Yogesh AU - Saini Y AUID- ORCID: 0000-0002-8324-2122 AD - Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. LA - eng GR - R01ES030125/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20220830 PL - Switzerland TA - Methods Protoc JT - Methods and protocols JID - 101720073 PMC - PMC9498385 OTO - NOTNLM OT - BMDM OT - M1 OT - M2 OT - alternatively-activated macrophages (AAM) OT - classically-activated macrophages (CAM) OT - macrophage OT - macrophage activation COIS- The authors declare no conflict of interest. EDAT- 2022/09/23 06:00 MHDA- 2022/09/23 06:01 PMCR- 2022/08/30 CRDT- 2022/09/22 13:04 PHST- 2022/08/02 00:00 [received] PHST- 2022/08/25 00:00 [revised] PHST- 2022/08/26 00:00 [accepted] PHST- 2022/09/22 13:04 [entrez] PHST- 2022/09/23 06:00 [pubmed] PHST- 2022/09/23 06:01 [medline] PHST- 2022/08/30 00:00 [pmc-release] AID - mps5050068 [pii] AID - mps-05-00068 [pii] AID - 10.3390/mps5050068 [doi] PST - epublish SO - Methods Protoc. 2022 Aug 30;5(5):68. doi: 10.3390/mps5050068. PMID- 35422337 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221114 IS - 1879-2022 (Electronic) IS - 0019-0578 (Linking) VI - 130 DP - 2022 Nov TI - Crash mitigation controller for unavoidable T-bone collisions using reinforcement learning. PG - 629-654 LID - S0019-0578(22)00142-2 [pii] LID - 10.1016/j.isatra.2022.03.021 [doi] AB - T-bone collision constitutes an emergency crash scenario that results in casualties and heavy losses; it is an excessively complicated scenario that cannot be handled by conventional control systems. This paper presents an innovative crash mitigation controller for application during unavoidable T-bone collisions to expand the vehicle-maneuverability envelope and minimize crash severity; this controller combines prior knowledge using an optimum expert-behavior policy and drift-operation mechanism based on an improved reinforcement learning algorithm, TD3. Vehicle and tire modeling are performed considering the nonlinear and coupled dynamics characteristics to improve control accuracy. Unlike conventional control systems and other reinforcement learning algorithms, the proposed controller realizes the optimum crash mitigation effect under different scenarios. It is expected to afford autonomous driving technologies with enhanced operating capabilities under extreme conditions. CI - Copyright © 2022 ISA. Published by Elsevier Ltd. All rights reserved. FAU - Hou, Xiaohui AU - Hou X AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. FAU - Zhang, Junzhi AU - Zhang J AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. Electronic address: thu_znqzd@163.com. FAU - He, Chengkun AU - He C AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. FAU - Li, Chao AU - Li C AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. FAU - Ji, Yuan AU - Ji Y AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. FAU - Han, Jinheng AU - Han J AD - State Key Laboratory of Automotive Safety and Energy, Tsinghua University, Beijing 100084, China; School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China. LA - eng PT - Journal Article DEP - 20220325 PL - United States TA - ISA Trans JT - ISA transactions JID - 0374750 SB - IM OTO - NOTNLM OT - Crash mitigation controller OT - Drift operation mechanism OT - Nonlinear dynamics OT - Reinforcement learning OT - T-bone collision COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/04/16 06:00 MHDA- 2022/04/16 06:01 CRDT- 2022/04/15 05:21 PHST- 2021/05/07 00:00 [received] PHST- 2022/02/23 00:00 [revised] PHST- 2022/03/19 00:00 [accepted] PHST- 2022/04/16 06:00 [pubmed] PHST- 2022/04/16 06:01 [medline] PHST- 2022/04/15 05:21 [entrez] AID - S0019-0578(22)00142-2 [pii] AID - 10.1016/j.isatra.2022.03.021 [doi] PST - ppublish SO - ISA Trans. 2022 Nov;130:629-654. doi: 10.1016/j.isatra.2022.03.021. Epub 2022 Mar 25. PMID- 25626170 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150630 LR - 20150128 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 6 DP - 2015 Jan 27 TI - A dendrite-suppressing composite ion conductor from aramid nanofibres. PG - 6152 LID - 10.1038/ncomms7152 [doi] AB - Dendrite growth threatens the safety of batteries by piercing the ion-transporting separators between the cathode and anode. Finding a dendrite-suppressing material that combines high modulus and high ionic conductance has long been considered a major technological and materials science challenge. Here we demonstrate that these properties can be attained in a composite made from Kevlar-derived aramid nanofibres assembled in a layer-by-layer manner with poly(ethylene oxide). Importantly, the porosity of the membranes is smaller than the growth area of the dendrites so that aramid nanofibres eliminate 'weak links' where the dendrites pierce the membranes. The aramid nanofibre network suppresses poly(ethylene oxide) crystallization detrimental for ion transport, giving a composite that exhibits high modulus, ionic conductivity, flexibility, ion flux rates and thermal stability. Successful suppression of hard copper dendrites by the composite ion conductor at extreme discharge conditions is demonstrated, thereby providing a new approach for the materials engineering of solid ion conductors. FAU - Tung, Siu-On AU - Tung SO AD - Macromolecular Science and Engineering, University of Michigan, 2300 Hayward, Ann Arbor, Michigan 48109, USA. FAU - Ho, Szushen AU - Ho S AD - Electrified Powertrain Engineering, Ford Motor Company, 1201 Village Road, Dearborn, Michigan 48121, USA. FAU - Yang, Ming AU - Yang M AD - Key Laboratory of Microsystems and Micronanostructures Manufacturing, Harbin Institute of Technology, 2 Yikuang Street, Ann Arbor, Harbin 150080, P. R. China. FAU - Zhang, Ruilin AU - Zhang R AD - Department of Material Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA. FAU - Kotov, Nicholas A AU - Kotov NA AD - Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150127 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 EDAT- 2015/01/28 06:00 MHDA- 2015/01/28 06:01 CRDT- 2015/01/28 06:00 PHST- 2013/12/29 00:00 [received] PHST- 2014/12/17 00:00 [accepted] PHST- 2015/01/28 06:00 [entrez] PHST- 2015/01/28 06:00 [pubmed] PHST- 2015/01/28 06:01 [medline] AID - ncomms7152 [pii] AID - 10.1038/ncomms7152 [doi] PST - epublish SO - Nat Commun. 2015 Jan 27;6:6152. doi: 10.1038/ncomms7152. PMID- 28538881 OWN - NLM STAT- MEDLINE DCOM- 20171006 LR - 20191120 IS - 1806-4841 (Electronic) IS - 0365-0596 (Print) IS - 0365-0596 (Linking) VI - 92 IP - 2 DP - 2017 Mar-Apr TI - Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris. PG - 212-216 LID - S0365-05962017000200212 [pii] LID - 10.1590/abd1806-4841.20175273 [doi] AB - Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid. FAU - Al-Talib, Hassanain AU - Al-Talib H AD - Laboratory Medical Science Cluster, Faculty of Medicine, Universiti Teknologi MARA (UiTM) - Sungai Buloh, Malaysia. FAU - Al-Khateeb, Alyaa AU - Al-Khateeb A AD - Biochemistry and Molecular Medicine Discipline, Faculty of Medicine, Universiti Teknologi MARA (UiTM) - Sungai Buloh, Malaysia. FAU - Hameed, Ayad AU - Hameed A AD - Faculty of Medicine and Health Sciences, Ucsi University - Kuala Lumpur, Malaysia. FAU - Murugaiah, Chandrika AU - Murugaiah C AD - Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah - Sabah, Malaysia. LA - eng PT - Journal Article PT - Review PL - Spain TA - An Bras Dermatol JT - Anais brasileiros de dermatologia JID - 0067662 RN - 0 (Glycolates) RN - 0 (Keratolytic Agents) RN - 0 (Salicylates) RN - 0WT12SX38S (glycolic acid) RN - O414PZ4LPZ (Salicylic Acid) SB - IM MH - Acne Vulgaris/*therapy MH - Chemexfoliation/adverse effects/*methods MH - Erythema/etiology MH - Glycolates/*therapeutic use MH - Humans MH - Keratolytic Agents/*therapeutic use MH - Salicylates MH - Salicylic Acid/*therapeutic use MH - Treatment Outcome PMC - PMC5429107 COIS- Conflict of interest: none. EDAT- 2017/05/26 06:00 MHDA- 2017/10/07 06:00 PMCR- 2017/03/01 CRDT- 2017/05/25 06:00 PHST- 2015/10/22 00:00 [received] PHST- 2016/02/10 00:00 [accepted] PHST- 2017/05/25 06:00 [entrez] PHST- 2017/05/26 06:00 [pubmed] PHST- 2017/10/07 06:00 [medline] PHST- 2017/03/01 00:00 [pmc-release] AID - S0365-05962017000200212 [pii] AID - 10.1590/abd1806-4841.20175273 [doi] PST - ppublish SO - An Bras Dermatol. 2017 Mar-Apr;92(2):212-216. doi: 10.1590/abd1806-4841.20175273. PMID- 29788151 OWN - NLM STAT- MEDLINE DCOM- 20181217 LR - 20181217 IS - 1574-6976 (Electronic) IS - 0168-6445 (Linking) VI - 42 IP - 5 DP - 2018 Sep 1 TI - Sporulation environment influences spore properties in Bacillus: evidence and insights on underlying molecular and physiological mechanisms. PG - 614-626 LID - 10.1093/femsre/fuy021 [doi] AB - Bacterial spores are resistant to physical and chemical insults, which makes them a major concern for public health and industry. Spores help bacteria to survive extreme environmental conditions that vegetative cells cannot tolerate. Spore resistance and dormancy are important properties for applications in medicine, veterinary health, food safety, crop protection and other domains. The resistance of bacterial spores results from a protective multilayered structure and from the unique composition of the spore core. The mechanisms of sporulation and germination, the first stage after breaking of dormancy, and organization of spore structure have been extensively studied in Bacillus species. This review aims to illustrate how far the structure, composition and properties of spores are shaped by the environmental conditions in which spores form. We look at the physiological and molecular mechanisms underpinning how sporulation media and environment deeply affect spore yield, spore properties like resistance to wet heat and physical and chemical agents, germination and further growth. For example, spore core water content decreases as sporulation temperature increases, and resistance to wet heat increases. Controlling the fate of Bacillus spores is pivotal to controlling bacterial risks and process efficiencies in, for example, the food industry, and better control hinges on better understanding how sporulation conditions influence spore properties. FAU - Bressuire-Isoard, Christelle AU - Bressuire-Isoard C AD - UMR408 SQPOV "Sécurité et Qualité des Produits d'Origine Végétale", INRA-Avignon Université, Centre de Recherche PACA, CS40509, Site Agroparc, 84914 Avignon Cedex 9, France. FAU - Broussolle, Véronique AU - Broussolle V AD - UMR408 SQPOV "Sécurité et Qualité des Produits d'Origine Végétale", INRA-Avignon Université, Centre de Recherche PACA, CS40509, Site Agroparc, 84914 Avignon Cedex 9, France. FAU - Carlin, Frédéric AU - Carlin F AD - UMR408 SQPOV "Sécurité et Qualité des Produits d'Origine Végétale", INRA-Avignon Université, Centre de Recherche PACA, CS40509, Site Agroparc, 84914 Avignon Cedex 9, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - FEMS Microbiol Rev JT - FEMS microbiology reviews JID - 8902526 RN - 0 (Bacterial Proteins) SB - IM MH - Bacillus/genetics/*physiology MH - Bacterial Proteins/genetics/metabolism MH - *Environment MH - Spores, Bacterial/*chemistry/metabolism EDAT- 2018/05/23 06:00 MHDA- 2018/12/18 06:00 CRDT- 2018/05/23 06:00 PHST- 2017/09/28 00:00 [received] PHST- 2018/05/16 00:00 [accepted] PHST- 2018/05/23 06:00 [pubmed] PHST- 2018/12/18 06:00 [medline] PHST- 2018/05/23 06:00 [entrez] AID - 4998855 [pii] AID - 10.1093/femsre/fuy021 [doi] PST - ppublish SO - FEMS Microbiol Rev. 2018 Sep 1;42(5):614-626. doi: 10.1093/femsre/fuy021. PMID- 32584802 OWN - NLM STAT- MEDLINE DCOM- 20200629 LR - 20220126 IS - 1545-861X (Electronic) IS - 0149-2195 (Print) IS - 0149-2195 (Linking) VI - 69 IP - 25 DP - 2020 Jun 26 TI - Potential Indirect Effects of the COVID-19 Pandemic on Use of Emergency Departments for Acute Life-Threatening Conditions - United States, January-May 2020. PG - 795-800 LID - 10.15585/mmwr.mm6925e2 [doi] AB - On March 13, 2020, the United States declared a national emergency in response to the coronavirus disease 2019 (COVID-19) pandemic. Subsequently, states enacted stay-at-home orders to slow the spread of SARS-CoV-2, the virus that causes COVID-19, and reduce the burden on the U.S. health care system. CDC* and the Centers for Medicare & Medicaid Services (CMS)(†) recommended that health care systems prioritize urgent visits and delay elective care to mitigate the spread of COVID-19 in health care settings. By May 2020, national syndromic surveillance data found that emergency department (ED) visits had declined 42% during the early months of the pandemic (1). This report describes trends in ED visits for three acute life-threatening health conditions (myocardial infarction [MI, also known as heart attack], stroke, and hyperglycemic crisis), immediately before and after declaration of the COVID-19 pandemic as a national emergency. These conditions represent acute events that always necessitate immediate emergency care, even during a public health emergency such as the COVID-19 pandemic. In the 10 weeks following the emergency declaration (March 15-May 23, 2020), ED visits declined 23% for MI, 20% for stroke, and 10% for hyperglycemic crisis, compared with the preceding 10-week period (January 5-March 14, 2020). EDs play a critical role in diagnosing and treating life-threatening conditions that might result in serious disability or death. Persons experiencing signs or symptoms of serious illness, such as severe chest pain, sudden or partial loss of motor function, altered mental state, signs of extreme hyperglycemia, or other life-threatening issues, should seek immediate emergency care, regardless of the pandemic. Clear, frequent, highly visible communication from public health and health care professionals is needed to reinforce the importance of timely care for medical emergencies and to assure the public that EDs are implementing infection prevention and control guidelines that help ensure the safety of their patients and health care personnel. FAU - Lange, Samantha J AU - Lange SJ FAU - Ritchey, Matthew D AU - Ritchey MD FAU - Goodman, Alyson B AU - Goodman AB FAU - Dias, Taylor AU - Dias T FAU - Twentyman, Evelyn AU - Twentyman E FAU - Fuld, Jennifer AU - Fuld J FAU - Schieve, Laura A AU - Schieve LA FAU - Imperatore, Giuseppina AU - Imperatore G FAU - Benoit, Stephen R AU - Benoit SR FAU - Kite-Powell, Aaron AU - Kite-Powell A FAU - Stein, Zachary AU - Stein Z FAU - Peacock, Georgina AU - Peacock G FAU - Dowling, Nicole F AU - Dowling NF FAU - Briss, Peter A AU - Briss PA FAU - Hacker, Karen AU - Hacker K FAU - Gundlapalli, Adi V AU - Gundlapalli AV FAU - Yang, Quanhe AU - Yang Q LA - eng PT - Journal Article DEP - 20200626 PL - United States TA - MMWR Morb Mortal Wkly Rep JT - MMWR. Morbidity and mortality weekly report JID - 7802429 SB - IM MH - Acute Disease MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - COVID-19 MH - Coronavirus Infections/*epidemiology MH - Emergency Service, Hospital/*statistics & numerical data MH - Facilities and Services Utilization/*trends MH - Female MH - Humans MH - Hyperglycemia/*therapy MH - Male MH - Middle Aged MH - Myocardial Infarction/*therapy MH - *Pandemics MH - Pneumonia, Viral/*epidemiology MH - Stroke/*therapy MH - United States/epidemiology MH - Young Adult PMC - PMC7316316 COIS- All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed. EDAT- 2020/06/26 06:00 MHDA- 2020/07/01 06:00 PMCR- 2020/06/26 CRDT- 2020/06/26 06:00 PHST- 2020/06/26 06:00 [entrez] PHST- 2020/06/26 06:00 [pubmed] PHST- 2020/07/01 06:00 [medline] PHST- 2020/06/26 00:00 [pmc-release] AID - mm6925e2 [pii] AID - 10.15585/mmwr.mm6925e2 [doi] PST - epublish SO - MMWR Morb Mortal Wkly Rep. 2020 Jun 26;69(25):795-800. doi: 10.15585/mmwr.mm6925e2. PMID- 23801234 OWN - NLM STAT- MEDLINE DCOM- 20130903 LR - 20130626 IS - 0034-1193 (Print) IS - 0034-1193 (Linking) VI - 104 IP - 6 DP - 2013 Jun TI - [A perspective for the role of drug registries in the post-marketing surveillance]. PG - 280-7 LID - 10.1701/1295.14331 [doi] AB - Drug registries are implemented after the authorization of new products and represent a tool for systematic collection of data aimed at obtaining additional knowledge on appropriateness, effectiveness and safety. The design of registries needs to be coherent with the main objective and a study protocol is required before the implementation. A registry aimed at the appropriateness of drug use should be primarily considered for high cost drugs when there is a risk, either for the patients' safety or for public expenditure, in using the drug outside the approved indications. Since the registry is a condition for the access to drugs, and all users are included, an extremely simplified data collection is required. However, the data should be available at regional level to allow record linkage procedures with other databases for conducting outcome studies. When registries are aimed at acquiring new information on the risk profile, the duration and the regional extension of data collection should be coherent with the expected incidence of events of interest. A great attention should be devoted in preventing that patients are lost to follow-up, since the reasons for being lost are frequently associated with harmful outcomes, such as adverse drug reactions. In a registry focused on effectiveness, the main aim consists in ascertaining the reasons (the prognostic factors), for possible discrepancies between premarketing studies and clinical practice. Taking into account the greater incidence of the expected events, there are fewer reasons for extending data collection to all users, whereas the main attention should focus on quality controls and the ascertainment of confounding factors. Given the relevance of the validity issues, in the set out of a registry it is important to think about ad hoc resources and the adequacy of infrastructures. As for any epidemiological study, an adequate qualification of the researcher/clinician in charge of conducting a registry should be guaranteed, together with independence in data analysis and freedom to publish all findings. FAU - Traversa, Giuseppe AU - Traversa G AD - Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità, Roma. giuseppe.traversa@iss.it FAU - Sagliocca, Luciano AU - Sagliocca L FAU - Magrini, Nicola AU - Magrini N FAU - Venegoni, Mauro AU - Venegoni M LA - ita PT - English Abstract PT - Journal Article TT - Una prospettiva per i registri nella sorveglianza post-marketing dei farmaci. PL - Italy TA - Recenti Prog Med JT - Recenti progressi in medicina JID - 0401271 SB - IM MH - *Drug Industry MH - Humans MH - *Product Surveillance, Postmarketing MH - *Registries EDAT- 2013/06/27 06:00 MHDA- 2013/09/04 06:00 CRDT- 2013/06/27 06:00 PHST- 2013/06/27 06:00 [entrez] PHST- 2013/06/27 06:00 [pubmed] PHST- 2013/09/04 06:00 [medline] AID - 10.1701/1295.14331 [doi] PST - ppublish SO - Recenti Prog Med. 2013 Jun;104(6):280-7. doi: 10.1701/1295.14331. PMID- 29019953 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20180301 LR - 20181113 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 17 IP - 10 DP - 2017 Oct 11 TI - Assessment of Ionospheric Gradient Impacts on Ground-Based Augmentation System (GBAS) Data in Guangdong Province, China. LID - 10.3390/s17102313 [doi] LID - 2313 AB - Ionospheric delay is one of the largest and most variable sources of error for Ground-Based Augmentation System (GBAS) users because inospheric activity is unpredictable. Under normal conditions, GBAS eliminates ionospheric delays, but during extreme ionospheric storms, GBAS users and GBAS ground facilities may experience different ionospheric delays, leading to considerable differential errors and threatening the safety of users. Therefore, ionospheric monitoring and assessment are important parts of GBAS integrity monitoring. To study the effects of the ionosphere on the GBAS of Guangdong Province, China, GPS data collected from 65 reference stations were processed using the improved "Simple Truth" algorithm. In addition, the ionospheric characteristics of Guangdong Province were calculated and an ionospheric threat model was established. Finally, we evaluated the influence of the standard deviation and maximum ionospheric gradient on GBAS. The results show that, under normal ionospheric conditions, the vertical protection level of GBAS was increased by 0.8 m for the largest over bound σ v i g (sigma of vertical ionospheric gradient), and in the case of the maximum ionospheric gradient conditions, the differential correction error may reach 5 m. From an airworthiness perspective, when the satellite is at a low elevation, this interference does not cause airworthiness risks, but when the satellite is at a high elevation, this interference can cause airworthiness risks. FAU - Wang, Zhipeng AU - Wang Z AD - National Key Laboratory of CNS/ATM, School of Electronic and Information Engineering, Beihang University, Beijing 100191,China. wangzhipeng@buaa.edu.cn. FAU - Wang, Shujing AU - Wang S AD - National Key Laboratory of CNS/ATM, School of Electronic and Information Engineering, Beihang University, Beijing 100191,China. wangshujing@buaa.edu.cn. FAU - Zhu, Yanbo AU - Zhu Y AD - National Key Laboratory of CNS/ATM, School of Electronic and Information Engineering, Beihang University, Beijing 100191,China. zhuyanbo@buaa.edu.cn. FAU - Xin, Pumin AU - Xin P AD - National Key Laboratory of CNS/ATM, School of Electronic and Information Engineering, Beihang University, Beijing 100191,China. dearmin1992@buaa.edu.cn. LA - eng PT - Journal Article DEP - 20171011 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 PMC - PMC5676670 OTO - NOTNLM OT - GBAS OT - airworthiness assessment OT - ionosphere monitoring OT - ionospheric threat model COIS- The authors declare no conflict of interest. EDAT- 2017/10/12 06:00 MHDA- 2017/10/12 06:01 PMCR- 2017/10/01 CRDT- 2017/10/12 06:00 PHST- 2017/07/30 00:00 [received] PHST- 2017/09/29 00:00 [revised] PHST- 2017/09/29 00:00 [accepted] PHST- 2017/10/12 06:00 [entrez] PHST- 2017/10/12 06:00 [pubmed] PHST- 2017/10/12 06:01 [medline] PHST- 2017/10/01 00:00 [pmc-release] AID - s17102313 [pii] AID - sensors-17-02313 [pii] AID - 10.3390/s17102313 [doi] PST - epublish SO - Sensors (Basel). 2017 Oct 11;17(10):2313. doi: 10.3390/s17102313. PMID- 20515835 OWN - NLM STAT- MEDLINE DCOM- 20100914 LR - 20220318 IS - 1945-0524 (Electronic) IS - 1945-0516 (Linking) VI - 2 IP - 3 DP - 2010 Jun 1 TI - Physiological modeling for technical, clinical and research applications. PG - 939-68 AB - Various and disparate technical disciplines have identified a growing need for tools to predict human thermal and thermoregulatory responses to environmental heating and cooling and other thermal challenges such as anesthesia and non-ionizing radiation. In this contribution, a dynamic simulation model is presented and used to predict human thermophysiological and perceptual responses for different applications and situations. The multi-segmental, multi-layered mathematical model predicts body temperatures, thermoregulatory responses, and components of the environmental heat exchange in cold, moderate, as well as hot stress conditions. The incorporated comfort model uses physiological states of the human body to predict thermal sensation responses to steady state and transient conditions. Different validation studies involving climate-chamber physiological and thermal comfort experiments, exposures to uncontrolled outdoor weather conditions, extreme climatic and radiation asymmetry scenarios revealed the model to predict physiological and perceptual responses typically within the standard deviation of the experimental observations. Applications of the model in biometeorology, clothing research, the car industry, clinical and safety applications are presented and discussed. FAU - Fiala, Dusan AU - Fiala D AD - ErgonSim, Comfort Energy Efficiency, Holderbuschweg 47, D-7056 Stuttgart, Germany. dfiala@ergonsim.de FAU - Psikuta, Agnes AU - Psikuta A FAU - Jendritzky, Gerd AU - Jendritzky G FAU - Paulke, Stefan AU - Paulke S FAU - Nelson, David A AU - Nelson DA FAU - Lichtenbelt, Wouter D van Marken AU - Lichtenbelt WD FAU - Frijns, Arjan J H AU - Frijns AJ LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PT - Validation Study DEP - 20100601 PL - Singapore TA - Front Biosci (Schol Ed) JT - Frontiers in bioscience (Scholar edition) JID - 101485241 SB - IM MH - Automobiles MH - Body Temperature/physiology MH - Body Temperature Regulation/*physiology MH - Climate MH - Clothing MH - Cold Temperature/adverse effects MH - Computer Simulation MH - Feedback, Physiological MH - Hot Temperature/adverse effects MH - Humans MH - Manikins MH - Meteorology MH - *Models, Biological MH - Regression Analysis MH - Sensation/physiology MH - Shivering/physiology MH - Skin/blood supply MH - Skin Temperature/physiology MH - Software MH - Sweating/physiology MH - Temperature RF - 80 EDAT- 2010/06/03 06:00 MHDA- 2010/09/15 06:00 CRDT- 2010/06/03 06:00 PHST- 2010/06/03 06:00 [entrez] PHST- 2010/06/03 06:00 [pubmed] PHST- 2010/09/15 06:00 [medline] AID - 112 [pii] AID - 10.2741/s112 [doi] PST - epublish SO - Front Biosci (Schol Ed). 2010 Jun 1;2(3):939-68. doi: 10.2741/s112. PMID- 38133270 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231224 IS - 2076-0817 (Print) IS - 2076-0817 (Electronic) IS - 2076-0817 (Linking) VI - 12 IP - 12 DP - 2023 Nov 24 TI - Pharmacokinetics and Safety of Group A and B Anti-Tuberculosis Drugs Used in Treatment of Rifampicin-Resistant Tuberculosis during Pregnancy and Post-Partum: A Narrative Review. LID - 10.3390/pathogens12121385 [doi] LID - 1385 AB - Recommendations for treatment of rifampicin-resistant tuberculosis (RR-TB) during pregnancy and post-partum now include Group A and B antituberculosis drugs. While pharmacokinetic data for most of these drugs among adults receiving treatment for RR-TB are limited, the data from pregnant patients and their infants are extremely scarce. Existing data suggest that fluoroquinolones, bedaquiline, clofazimine and terizidone may be used safely in pregnancy. Pharmacokinetic exposures, particularly between trimesters, are potentially sub-optimal; however, there is currently no evidence to support dose adjustment during pregnancy. Linezolid poses a potentially serious toxicity risk, particularly as exposures appear to be high in the later stages of pregnancy and post-partum following extended use, but this should be considered alongside the benefits of this extremely effective drug in the treatment of this life-threatening disease. While plenty of questions remain regarding the exposure to Group A and B antituberculosis drugs through breastmilk, existing literature suggests minimal harm to the breastfed infant. Pregnant patients and their infants should be included in therapeutic trials and pharmacokinetic studies of effective antituberculosis drugs. FAU - Hughes, Jennifer AU - Hughes J AUID- ORCID: 0000-0002-5349-9509 AD - Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7500, South Africa. LA - eng PT - Journal Article PT - Review DEP - 20231124 PL - Switzerland TA - Pathogens JT - Pathogens (Basel, Switzerland) JID - 101596317 PMC - PMC10745846 OTO - NOTNLM OT - pharmacokinetics OT - post-partum OT - pregnancy OT - rifampicin-resistant tuberculosis OT - safety COIS- The author declares no conflict of interest. EDAT- 2023/12/22 12:42 MHDA- 2023/12/22 12:43 PMCR- 2023/11/24 CRDT- 2023/12/22 09:24 PHST- 2023/10/03 00:00 [received] PHST- 2023/11/06 00:00 [revised] PHST- 2023/11/14 00:00 [accepted] PHST- 2023/12/22 12:43 [medline] PHST- 2023/12/22 12:42 [pubmed] PHST- 2023/12/22 09:24 [entrez] PHST- 2023/11/24 00:00 [pmc-release] AID - pathogens12121385 [pii] AID - pathogens-12-01385 [pii] AID - 10.3390/pathogens12121385 [doi] PST - epublish SO - Pathogens. 2023 Nov 24;12(12):1385. doi: 10.3390/pathogens12121385. PMID- 36188363 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221004 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 13 DP - 2022 TI - The sensitivity and specificity of the modified volume-viscosity swallow test for dysphagia screening among neurological patients. PG - 961893 LID - 10.3389/fneur.2022.961893 [doi] LID - 961893 AB - Oropharyngeal dysphagia (OD) is a highly prevalent condition after stroke and other neurological diseases. The volume-viscosity swallow test (V-VST) is a screening tool for OD. Considering that the recommendations of volume and thickeners in the original V-VST limited the popularization and application of the test in the Chinese population, we provide the modified V-VST to detect OD among neurological patients. In addition, the accuracy of the modified V-VST to screen OD needs to be verified. We included 101 patients with neurological diseases. OD was evaluated by a modified V-VST and a videofluoroscopy swallowing study (VFSS) using 3 volumes (i.e., 3, 5, and 10 ml) and 4 viscosities (i.e., water, mildly thick, moderately thick, and extremely thick). In this study, to compare with the original V-VST results, a volume of 20 ml was also included. The discriminating ability of modified V-VST in detecting OD was assessed by the sensitivity and specificity values of clinical signs of impaired efficiency (impaired labial seal, piecemeal deglutition, and residue) and impaired safety of swallowing (cough, voice changes, and oxygen desaturation ≥3%) in comparison to the results of VFSS. The modified V-VST showed 96.6% sensitivity and 83.3% specificity for OD, 85.2% sensitivity and 70% specificity for impaired safety, and 90.9% sensitivity and 76.9% specificity for impaired efficacy. Our study suggests that the modified V-VST offers a high discriminating ability in detecting OD among neurological patients. CI - Copyright © 2022 Lin, Wan, Wu, Shi, Zhang, Chen, Wei, Tang, Dai, Dou and Wen. FAU - Lin, Yiqiu AU - Lin Y AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wan, Guifang AU - Wan G AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wu, Huixiang AU - Wu H AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Shi, Jing AU - Shi J AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Zhang, Yaowen AU - Zhang Y AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Chen, Huayu AU - Chen H AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wei, Xiaomei AU - Wei X AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Tang, Zhiming AU - Tang Z AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Dai, Meng AU - Dai M AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Dou, Zulin AU - Dou Z AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wen, Hongmei AU - Wen H AD - Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20220916 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC9523084 OTO - NOTNLM OT - dysphagia OT - modified volume-viscosity swallow test OT - neurological diseases OT - screening OT - sensitivity OT - specificity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/10/04 06:00 MHDA- 2022/10/04 06:01 PMCR- 2022/09/16 CRDT- 2022/10/03 05:07 PHST- 2022/06/05 00:00 [received] PHST- 2022/08/22 00:00 [accepted] PHST- 2022/10/03 05:07 [entrez] PHST- 2022/10/04 06:00 [pubmed] PHST- 2022/10/04 06:01 [medline] PHST- 2022/09/16 00:00 [pmc-release] AID - 10.3389/fneur.2022.961893 [doi] PST - epublish SO - Front Neurol. 2022 Sep 16;13:961893. doi: 10.3389/fneur.2022.961893. eCollection 2022. PMID- 32266490 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20200601 IS - 1437-1588 (Electronic) IS - 1436-9990 (Linking) VI - 63 IP - 5 DP - 2020 May TI - [Narratives help disseminate medical technologies: the case of coronary interventions]. PG - 521-526 LID - 10.1007/s00103-020-03130-x [doi] AB - Medical technologies are often disseminated and used although evidence demonstrating their effectiveness and safety is missing. Percutaneous intervention (PCI) in stable coronary artery disease (CAD) is an example. This raises the question of how these technologies get disseminated and on which basis they are accepted by clinicians, patients, and the wider public.Studies investigating the communication between clinicians and patients show that simple narratives play a decisive role here. In this paper I discuss how narratives contribute to the dissemination of medical technologies. Communication within the profession, which includes medical education, also relies on narratives to a large degree. They have the following characteristics in common: 1) extreme simplification, 2) reduction to biological processes, 3) deterministic logic, and 4) strong moral message. These narratives are always biased; narratives dealing with interventions paint an overoptimistic picture of their effectiveness and safety. Although they represent "modern" technologies, their logic and purpose are akin to archaic myths.Presumably education and persuasion cannot eschew narratives completely. But health professionals, patients and the public should be aware of the inevitable bias that comes with narratives and their potential for manipulation. FAU - Donner-Banzhoff, Norbert AU - Donner-Banzhoff N AD - Abteilung für Allgemeinmedizin, Präventive und Rehabilitative Medizin, Philipps-Universität Marburg, Karl-von-Frisch-Str. 4, 35043, Marburg, Deutschland. norbert@staff.uni-marburg.de. LA - ger PT - Journal Article PT - Review TT - Mechanistische Narrative als Mittel der Dissemination: das Beispiel koronarer Technologien. PL - Germany TA - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz JT - Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz JID - 101181368 SB - IM MH - Angioplasty, Balloon, Coronary MH - Coronary Artery Disease/*surgery MH - *Diffusion of Innovation MH - Education, Medical MH - Germany MH - Humans MH - Mythology MH - *Narration MH - *Percutaneous Coronary Intervention MH - Persuasive Communication MH - *Technology Assessment, Biomedical OTO - NOTNLM OT - Angioplasty, Balloon, Coronary OT - Diffusion of innovation OT - Mythology OT - Narration OT - Technology assessment, Biomedical EDAT- 2020/04/09 06:00 MHDA- 2020/06/02 06:00 CRDT- 2020/04/09 06:00 PHST- 2020/04/09 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2020/04/09 06:00 [entrez] AID - 10.1007/s00103-020-03130-x [pii] AID - 10.1007/s00103-020-03130-x [doi] PST - ppublish SO - Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 May;63(5):521-526. doi: 10.1007/s00103-020-03130-x. PMID- 37674454 OWN - NLM STAT- MEDLINE DCOM- 20231102 LR - 20231102 IS - 1972-6007 (Electronic) IS - 0009-9074 (Linking) VI - 174 IP - 3 DP - 2023 Sep-Oct TI - A Closer Look at Anatomy Educator Safety: Identifying and Preventing Workplace Hazards: A narrative review. PG - 436-443 LID - 10.7417/CT.2023.2462 [doi] AB - Anatomy, one of medicine's vital subjects, demands extreme visualization to understand the intricate architecture of the human body. Although various other methods of virtual dissections are in place, an increasing number of anatomists, clinicians, and surgeons are advocating for re-enhancing anatomical education through traditional cadaveric dissection. These traditional pedagogies potentially expose anatomy educators to various risks in the dissection laboratory, which endangers their health and well-being. Unfortunately, no one is counting on them or the hazards they face. It's like saying, "Fall ill at your own peril." Various studies have revealed the occupational hazards anatomists are exposed to, but the issue remains unheard of or relatively heard. Hence, this narrative review aims to highlight numerous occupational risks that anatomists face worldwide, particularly in underdeveloped or developing nations. Simultaneously, the authors strongly advocate that competent authorities review and evaluate the working conditions of anatomy laboratories and frame policies that ensure the rights and optimal health of anatomy educators. FAU - Patra, A AU - Patra A AD - Department of Anatomy, All India Institute of Medical Sciences, Bathinda, India. FAU - Asghar, A AU - Asghar A AD - Department of Anatomy, All India Institute of Medical Sciences, Patna, India. FAU - Pushpa, N B AU - Pushpa NB AD - Department of Anatomy, JSS Medical College, Mysore, India. FAU - Ravi, K S AU - Ravi KS AD - Department of Anatomy, All India Institute of Medical Sciences, Gorakhpur, India. LA - eng PT - Journal Article PT - Review PL - Italy TA - Clin Ter JT - La Clinica terapeutica JID - 0372604 SB - IM MH - Humans MH - *Education, Medical, Undergraduate/methods MH - *Students, Medical MH - Cadaver MH - Dissection/education MH - Workplace MH - *Anatomy/education MH - Curriculum OTO - NOTNLM OT - Anatomy education OT - Cadaver OT - Dissection OT - Hazards OT - Prosection EDAT- 2023/09/07 06:42 MHDA- 2023/09/07 06:43 CRDT- 2023/09/07 03:51 PHST- 2023/09/07 06:43 [medline] PHST- 2023/09/07 06:42 [pubmed] PHST- 2023/09/07 03:51 [entrez] AID - 10.7417/CT.2023.2462 [doi] PST - ppublish SO - Clin Ter. 2023 Sep-Oct;174(3):436-443. doi: 10.7417/CT.2023.2462. PMID- 16924266 OWN - NLM STAT- MEDLINE DCOM- 20060921 LR - 20181113 IS - 1744-4292 (Electronic) IS - 1744-4292 (Linking) VI - 2 DP - 2006 TI - Towards synthesis of a minimal cell. PG - 45 AB - Construction of a chemical system capable of replication and evolution, fed only by small molecule nutrients, is now conceivable. This could be achieved by stepwise integration of decades of work on the reconstitution of DNA, RNA and protein syntheses from pure components. Such a minimal cell project would initially define the components sufficient for each subsystem, allow detailed kinetic analyses and lead to improved in vitro methods for synthesis of biopolymers, therapeutics and biosensors. Completion would yield a functionally and structurally understood self-replicating biosystem. Safety concerns for synthetic life will be alleviated by extreme dependence on elaborate laboratory reagents and conditions for viability. Our proposed minimal genome is 113 kbp long and contains 151 genes. We detail building blocks already in place and major hurdles to overcome for completion. FAU - Forster, Anthony C AU - Forster AC AD - Department of Pharmacology and Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. a.forster@vanderbilt.edu FAU - Church, George M AU - Church GM LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Review DEP - 20060822 PL - Germany TA - Mol Syst Biol JT - Molecular systems biology JID - 101235389 SB - IM MH - Biochemistry/*methods/trends MH - Biomimetics/*methods/trends MH - Cell-Free System MH - Cells/*metabolism MH - Gene Expression MH - Genome/genetics PMC - PMC1681520 EDAT- 2006/08/23 09:00 MHDA- 2006/09/22 09:00 PMCR- 2006/08/22 CRDT- 2006/08/23 09:00 PHST- 2006/05/07 00:00 [received] PHST- 2006/07/26 00:00 [accepted] PHST- 2006/08/23 09:00 [pubmed] PHST- 2006/09/22 09:00 [medline] PHST- 2006/08/23 09:00 [entrez] PHST- 2006/08/22 00:00 [pmc-release] AID - msb4100090 [pii] AID - 10.1038/msb4100090 [doi] PST - ppublish SO - Mol Syst Biol. 2006;2:45. doi: 10.1038/msb4100090. Epub 2006 Aug 22. PMID- 11822623 OWN - NLM STAT- MEDLINE DCOM- 20020719 LR - 20191105 IS - 1075-5535 (Print) IS - 1075-5535 (Linking) VI - 7 Suppl 1 DP - 2001 TI - The puzzle of homeopathy. PG - S103-9 AB - Homeopathy is a branch of Western medicine that has mostly been rejected by Western orthodoxy for the last 200 years because of conceptual and scientific clashes. Homeopathy uses microdoses of potential toxins to provoke defense and self-regulatory responses, rather than the more orthodox approach of blocking body reactions. This approach hints at its clinical scope: it can help, at times resolve, conditions that are intrinsically reversible rather than mechanical problems, deficiencies, or irreversible breakdowns in body functions where it is only palliative. In recent years, there has been a renaissance of interest. Public demand has soared, and with it professional interest. Approximately 20% of Scotland's general practitioners have completed basic training. This is partly occasioned by public interest in complementary medicine and a sympathy with the more mind-body approach of homeopathy, and partly by recent scientific evidence. Some homeopathic dilutions are so extreme they are dismissed by critics as only placebo. Yet trials and meta-analyses of controlled trials are pointing toward real effects, mechanism of action unknown. Clinical outcome studies suggest useful clinical impact and excellent safety. There seems to be a potential to enhance patient care by integrating the two systems. FAU - Reilly, D AU - Reilly D AD - Glasgow Homoeopathic Hospital, Scotland, United Kingdom. davidreilly@compuserve.com LA - eng PT - Journal Article PT - Review PL - United States TA - J Altern Complement Med JT - Journal of alternative and complementary medicine (New York, N.Y.) JID - 9508124 SB - IM MH - *Evidence-Based Medicine MH - Formularies, Homeopathic as Topic/*standards MH - Homeopathy/*methods/*standards MH - Humans MH - Meta-Analysis as Topic MH - Randomized Controlled Trials as Topic MH - Research Design MH - Scotland MH - Treatment Outcome MH - United States RF - 8 EDAT- 2002/02/02 10:00 MHDA- 2002/07/20 10:01 CRDT- 2002/02/02 10:00 PHST- 2002/02/02 10:00 [pubmed] PHST- 2002/07/20 10:01 [medline] PHST- 2002/02/02 10:00 [entrez] AID - 10.1089/107555301753393869 [doi] PST - ppublish SO - J Altern Complement Med. 2001;7 Suppl 1:S103-9. doi: 10.1089/107555301753393869. PMID- 31595774 OWN - NLM STAT- MEDLINE DCOM- 20200904 LR - 20200904 IS - 1542-6270 (Electronic) IS - 1060-0280 (Linking) VI - 54 IP - 3 DP - 2020 Mar TI - Trastuzumab/Hyaluronidase-oysk: A New Option for Patients With HER2-Positive Breast Cancer. PG - 254-261 LID - 10.1177/1060028019877936 [doi] AB - OBJECTIVE: To assess the use of subcutaneous trastuzumab/hyaluronidase-oysk (SQ trastuzumab) in comparison to intravenous (IV) trastuzumab. DATA SOURCES: A comprehensive PubMed literature search was performed from August 2012 to August 2019 using search terms Herceptin Hylecta, trastuzumab, hyaluronidase, subcutaneous, preference, safety, efficacy, and cost. STUDY SELECTION & DATA EXTRACTION: English-language clinical trials focusing on SQ trastuzumab were evaluated. DATA SYNTHESIS: In phase III trials, adverse event (AE) rates ranged from 64% to 97.6% of patients receiving SQ trastuzumab in 3 studies compared to 94.6% of patients receiving IV trastuzumab. In the phase III trial comparing SQ trastuzumab to IV trastuzumab, six-year overall survival (OS) was 84% in both groups. In pharmacokinetic analyses, trough concentrations and AUC0-21 were slightly higher in patients receiving SQ trastuzumab and differences were larger at the extremes of body weight. Two pharmacoeconomic analyses reported cost-savings associated with a 52-week treatment cycle of trastuzumab of $2,090 USD and $4,600 USD. RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE: Food and Drug Administration (FDA)-approved in February 2019, SQ trastuzumab, a monoclonal antibody that binds to human epidermal growth factor receptor 2 (HER2) protein in combination with hyaluronidase, offers an alternative dosage form for patients with breast tumors overexpressing HER2. CONCLUSIONS: SQ trastuzumab has a similar safety profile to IV trastuzumab. Although it may be slightly more cost-effective, its role in the treatment of HER2-overexpressing tumors requires further study in those at the extremes of body weight due to differences in drug exposure compared to IV trastuzumab. FAU - Duco, Marissa R AU - Duco MR AD - Butler University, Indianapolis, IN, USA. FAU - Murdock, Joshua L AU - Murdock JL AD - Butler University, Indianapolis, IN, USA. FAU - Reeves, David J AU - Reeves DJ AUID- ORCID: 0000-0002-1614-096X AD - Butler University, Indianapolis, IN, USA. AD - Franciscan Physician Network Oncology/Hematology Specialists, Indianapolis, IN, USA. LA - eng PT - Journal Article PT - Review DEP - 20191009 PL - United States TA - Ann Pharmacother JT - The Annals of pharmacotherapy JID - 9203131 RN - 0 (Antineoplastic Agents, Immunological) RN - EC 2.7.10.1 (ERBB2 protein, human) RN - EC 2.7.10.1 (Receptor, ErbB-2) RN - EC 3.2.1.35 (Hyaluronoglucosaminidase) RN - P188ANX8CK (Trastuzumab) SB - IM MH - Adult MH - Antineoplastic Agents, Immunological/administration & dosage/adverse effects/*therapeutic use MH - Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects/*therapeutic use MH - Breast Neoplasms/*drug therapy/immunology/metabolism/mortality MH - Clinical Trials, Phase III as Topic MH - Disease-Free Survival MH - Female MH - Humans MH - Hyaluronoglucosaminidase/administration & dosage/adverse effects/*therapeutic use MH - Injections, Intravenous MH - Injections, Subcutaneous MH - Middle Aged MH - Receptor, ErbB-2/*metabolism MH - Trastuzumab/administration & dosage/adverse effects/*therapeutic use OTO - NOTNLM OT - HER2 OT - Herceptin Hylecta OT - breast cancer OT - cost-effectiveness OT - hyaluronidase OT - subcutaneous OT - trastuzumab EDAT- 2019/10/10 06:00 MHDA- 2020/09/05 06:00 CRDT- 2019/10/10 06:00 PHST- 2019/10/10 06:00 [pubmed] PHST- 2020/09/05 06:00 [medline] PHST- 2019/10/10 06:00 [entrez] AID - 10.1177/1060028019877936 [doi] PST - ppublish SO - Ann Pharmacother. 2020 Mar;54(3):254-261. doi: 10.1177/1060028019877936. Epub 2019 Oct 9. PMID- 3579013 OWN - NLM STAT- MEDLINE DCOM- 19870529 LR - 20061115 IS - 0003-0805 (Print) IS - 0003-0805 (Linking) VI - 135 IP - 5 DP - 1987 May TI - Iatroepidemics: a probe to examine systematic preventable errors in (chest) medicine. PG - 1152-6 AB - Iatroepidemics are extreme examples of the inadequacies and errors that are prevalent in medicine. Their causes and evaluation are useful in demonstrating that medicine has a potentially destructive side as well as a highly constructive one. In the 1960s, the ATS left the sanitoria and joined the mainstream of medicine. In the 1980s it has become apparent that formal connections with science are not enough to ensure maximal safety for our patients. Nor are these connections sufficient to ensure maximal effectiveness of the measures we use to treat patients. A new awareness of our collective responsibility for improved patient outcome would be the obvious first step. Translating this sense of responsibility into new organizational approaches could place the ATS at the forefront of providing needed, and perhaps inevitable, reforms of medicine generally. FAU - Robin, E D AU - Robin ED LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am Rev Respir Dis JT - The American review of respiratory disease JID - 0370523 SB - IM MH - Diagnosis, Differential MH - Humans MH - Iatrogenic Disease/*prevention & control MH - *Thoracic Diseases/diagnosis/etiology/prevention & control EDAT- 1987/05/01 00:00 MHDA- 1987/05/01 00:01 CRDT- 1987/05/01 00:00 PHST- 1987/05/01 00:00 [pubmed] PHST- 1987/05/01 00:01 [medline] PHST- 1987/05/01 00:00 [entrez] AID - 10.1164/arrd.1987.135.5.1152 [doi] PST - ppublish SO - Am Rev Respir Dis. 1987 May;135(5):1152-6. doi: 10.1164/arrd.1987.135.5.1152. PMID- 18422481 OWN - NLM STAT- MEDLINE DCOM- 20080509 LR - 20151119 IS - 1744-7666 (Electronic) IS - 1465-6566 (Linking) VI - 9 IP - 7 DP - 2008 May TI - Tolterodine for the treatment of overactive bladder. PG - 1249-55 LID - 10.1517/14656566.9.7.1249 [doi] AB - BACKGROUND: The overactive bladder syndrome is a common condition affecting approximately 12% of men and women. It is extremely disturbing with a great impact on quality of life. Its treatment involves a combination of behavioural and pharmacological therapy. The latter includes antimuscarinic drugs such as tolterodine. OBJECTIVE: To review the safety and efficacy of tolterodine in the treatment of overactive bladder in comparison with other available antimuscarinic agents. METHODS: A Pubmed search was carried out differentiating randomised, clinical trials; longitudinal, retrospective studies; and metanalysis on the use of tolterodine for overactive bladder treatment. In the comparison with other antimuscarinic agents, only randomised, clinical trials were considered. RESULTS/CONCLUSION: Tolterodine is available as immediate- or extended-release formulations. It has been extensively evaluated with long-term, randomised trials for safety and efficacy showing a significant improvement in overactive bladder symptoms with an excellent tolerability profile. FAU - Salvatore, Stefano AU - Salvatore S AD - University of Insubria, Department of Obstetrics and Gynecology, Del Ponte Hospital, Via Ciro Menotti 76, 21100 Varese, Italy. stefanosalvatore@hotmail.com FAU - Serati, Maurizio AU - Serati M FAU - Bolis, Pierfrancesco AU - Bolis P LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - England TA - Expert Opin Pharmacother JT - Expert opinion on pharmacotherapy JID - 100897346 RN - 0 (Benzhydryl Compounds) RN - 0 (Cresols) RN - 0 (Delayed-Action Preparations) RN - 0 (Muscarinic Antagonists) RN - 33RU150WUN (Phenylpropanolamine) RN - 5T619TQR3R (Tolterodine Tartrate) SB - IM MH - Benzhydryl Compounds/*administration & dosage/adverse effects MH - Cresols/*administration & dosage/adverse effects MH - Delayed-Action Preparations MH - Female MH - Humans MH - Male MH - Muscarinic Antagonists/*administration & dosage/adverse effects/pharmacokinetics MH - Phenylpropanolamine/*administration & dosage/adverse effects MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - Tolterodine Tartrate MH - Urinary Bladder, Overactive/*drug therapy/epidemiology RF - 48 EDAT- 2008/04/22 09:00 MHDA- 2008/05/10 09:00 CRDT- 2008/04/22 09:00 PHST- 2008/04/22 09:00 [pubmed] PHST- 2008/05/10 09:00 [medline] PHST- 2008/04/22 09:00 [entrez] AID - 10.1517/14656566.9.7.1249 [doi] PST - ppublish SO - Expert Opin Pharmacother. 2008 May;9(7):1249-55. doi: 10.1517/14656566.9.7.1249. PMID- 33527310 OWN - NLM STAT- MEDLINE DCOM- 20220325 LR - 20220325 IS - 1612-9067 (Electronic) IS - 1612-9059 (Linking) VI - 18 IP - 2 DP - 2021 Apr TI - Fundoplication versus oral proton pump inhibitors for gastroesophageal reflux disease: a systematic review and meta-analysis of randomized clinical trials. PG - 173-180 LID - 10.1007/s10388-020-00806-w [doi] AB - Gastroesophageal reflux disease (GERD) is a widely studied and highly prevalent condition. However, few are reported about the exact efficacy and safety of fundoplication (FPT) compared to oral intake proton-pump inhibitors (PPI). This systematic review and meta-analysis of randomized clinical trials (RCT) aims to compare PPI and FPT in relation to the efficacy, as well as the adverse events associated with these therapies. Search carried out in June 2020 was conducted on Medline, Cochrane, EMBASE and LILACS. Selection was restricted to RCT comparing PPI and FPT (open or laparoscopic) in GERD patients. Certainty of evidence and risk of bias were assessed with GRADE Pro and with Review Manager Version 5.4 bias assessment tool. Ten RCT were included. Meta-analysis showed that heartburn (RD =  - 0.19; 95% CI =  - 0.29, - 0.09) was less frequently reported by patients that underwent FPT. Furthermore, patients undergoing surgery had greater pressure on the lower esophageal sphincter than those who used PPI (MD = 7.81; 95% CI 4.79, 10.83). Finally, FPT did not increase significantly the risk for adverse events such as postoperative dysphagia and impaired belching. FPT is a more effective therapy than PPI treatment for GERD, without significantly increasing the risk for adverse events. However, before indicating a possible surgical approach, it is extremely important to correctly assess and select the patients who would benefit from FPT to ensure better results. FAU - Tristão, Luca Schiliró AU - Tristão LS AUID- ORCID: 0000-0002-7197-0915 AD - Department of Evidence-Based Medicine, Centro Universitário Lusíada, R. Oswaldo Cruz, 179, Santos, São Paulo, 11045-101, Brazil. lucatristao@gmail.com. FAU - Tustumi, Francisco AU - Tustumi F AD - Department of Evidence-Based Medicine, Centro Universitário Lusíada, R. Oswaldo Cruz, 179, Santos, São Paulo, 11045-101, Brazil. AD - Department of Evidence-Based Medicine, Universidade de São Paulo, São Paulo, São Paulo, Brazil. AD - Department of Surgery, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil. FAU - Tavares, Guilherme AU - Tavares G AD - Department of Evidence-Based Medicine, Centro Universitário Lusíada, R. Oswaldo Cruz, 179, Santos, São Paulo, 11045-101, Brazil. FAU - Bernardo, Wanderley Marques AU - Bernardo WM AD - Department of Evidence-Based Medicine, Centro Universitário Lusíada, R. Oswaldo Cruz, 179, Santos, São Paulo, 11045-101, Brazil. AD - Department of Evidence-Based Medicine, Universidade de São Paulo, São Paulo, São Paulo, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review PT - Systematic Review DEP - 20210202 PL - Japan TA - Esophagus JT - Esophagus : official journal of the Japan Esophageal Society JID - 101206627 RN - 0 (Proton Pump Inhibitors) SB - IM MH - *Fundoplication/adverse effects/methods MH - *Gastroesophageal Reflux/drug therapy/etiology/surgery MH - Humans MH - Proton Pump Inhibitors/adverse effects MH - Randomized Controlled Trials as Topic MH - Treatment Outcome OTO - NOTNLM OT - Fundoplication OT - Gastroesophageal reflux OT - Meta-analysis OT - Proton pump inhibitors OT - Systematic review EDAT- 2021/02/03 06:00 MHDA- 2022/03/26 06:00 CRDT- 2021/02/02 06:13 PHST- 2020/09/20 00:00 [received] PHST- 2020/12/08 00:00 [accepted] PHST- 2021/02/03 06:00 [pubmed] PHST- 2022/03/26 06:00 [medline] PHST- 2021/02/02 06:13 [entrez] AID - 10.1007/s10388-020-00806-w [pii] AID - 10.1007/s10388-020-00806-w [doi] PST - ppublish SO - Esophagus. 2021 Apr;18(2):173-180. doi: 10.1007/s10388-020-00806-w. Epub 2021 Feb 2. PMID- 25341802 OWN - NLM STAT- MEDLINE DCOM- 20151013 LR - 20211021 IS - 1752-0509 (Electronic) IS - 1752-0509 (Linking) VI - 8 DP - 2014 Oct 24 TI - Computational modelling and analysis of the molecular network regulating sporulation initiation in Bacillus subtilis. PG - 119 LID - 10.1186/s12918-014-0119-x [doi] LID - 119 AB - BACKGROUND: Bacterial spores are important contaminants in food, and the spore forming bacteria are often implicated in food safety and food quality considerations. Spore formation is a complex developmental process involving the expression of more than 500 genes over the course of 6 to 8 hrs. The process culminates in the formation of resting cells capable of resisting environmental extremes and remaining dormant for long periods of time, germinating when conditions promote further vegetative growth. Experimental observations of sporulation and germination are problematic and time consuming so that reliable models are an invaluable asset in terms of prediction and risk assessment. In this report we develop a model which assists in the interpretation of sporulation dynamics. RESULTS: This paper defines and analyses a mathematical model for the network regulating Bacillus subtilis sporulation initiation, from sensing of sporulation signals down to the activation of the early genes under control of the master regulator Spo0A. Our model summarises and extends other published modelling studies, by allowing the user to execute sporulation initiation in a scenario where Isopropyl β-D-1-thiogalactopyranoside (IPTG) is used as an artificial sporulation initiator as well as in modelling the induction of sporulation in wild-type cells. The analysis of the model results and the comparison with experimental data indicate that the model is good at predicting inducible responses to sporulation signals. However, the model is unable to reproduce experimentally observed accumulation of phosphorelay sporulation proteins in wild type B. subtilis. This model also highlights that the phosphorelay sub-component, which relays the signals detected by the sensor kinases to the master regulator Spo0A, is crucial in determining the response dynamics of the system. CONCLUSION: We show that there is a complex connectivity between the phosphorelay features and the master regulatory Spo0A. Additional we discovered that the experimentally observed regulation of the phosphotransferase Spo0B for wild-type B. subtilis may be playing an important role in the network which suggests that modelling of sporulation initiation may require additional experimental support. FAU - Ihekwaba, Adaoha E C AU - Ihekwaba AE AD - Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK. Adaoha.ihekwaba@ifr.ac.uk. FAU - Mura, Ivan AU - Mura I AD - Faculty of Engineering, EAN University, Carrera 11 No. 78 - 47, Bogotá, Colombia. imura@ean.edu.co. FAU - Barker, Gary C AU - Barker GC AD - Gut Health and Food Safety, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK. gary.barker@ifr.ac.uk. LA - eng GR - BB/J004529/1/Biotechnology and Biological Sciences Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20141024 PL - England TA - BMC Syst Biol JT - BMC systems biology JID - 101301827 RN - 0 (Bacterial Proteins) RN - 0 (Spo0A protein, Bacillus subtilis) RN - 0 (Transcription Factors) RN - 0 (spore-specific proteins, Bacillus) SB - IM MH - Bacillus subtilis/*physiology MH - Bacterial Proteins/metabolism MH - Computational Biology/*methods MH - *Gene Regulatory Networks MH - *Models, Biological MH - Spores, Bacterial/genetics/*metabolism MH - Transcription Factors/metabolism PMC - PMC4213463 EDAT- 2014/10/25 06:00 MHDA- 2015/10/16 06:00 PMCR- 2014/10/24 CRDT- 2014/10/25 06:00 PHST- 2014/08/08 00:00 [received] PHST- 2014/10/13 00:00 [accepted] PHST- 2014/10/25 06:00 [entrez] PHST- 2014/10/25 06:00 [pubmed] PHST- 2015/10/16 06:00 [medline] PHST- 2014/10/24 00:00 [pmc-release] AID - s12918-014-0119-x [pii] AID - 119 [pii] AID - 10.1186/s12918-014-0119-x [doi] PST - epublish SO - BMC Syst Biol. 2014 Oct 24;8:119. doi: 10.1186/s12918-014-0119-x. PMID- 34582474 OWN - NLM STAT- MEDLINE DCOM- 20211118 LR - 20240403 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 16 IP - 9 DP - 2021 TI - Establishing a protocol for the compatibilities of closed-system transfer devices with multiple chemotherapy drugs under simulated clinical conditions. PG - e0257873 LID - 10.1371/journal.pone.0257873 [doi] LID - e0257873 AB - Closed-system drug transfer devices (CSTDs) are used to prevent occupational exposure to hazardous drugs in health care providers. They are considered Class II medical devices by the US FDA and are cleared but not approved before marketing. While compatibility tests are conducted by CSTD manufacturers, the procuring institution needs to consider performing its own studies before buying these devices. Herein we tested the compatibility of the components of the Needleless® DualGuard CSTD system (vial access clips, vial access spikes, and administration adaptors) with 10 antineoplastic drugs, under simulated clinical conditions, including compounding and administration, and examined drug potency maintenance, plasticizer migration, and device functionality. All drugs maintained potency within 5%. Diisononyl phthalate leakage was observed from the administration adaptors for paclitaxel and concentrated etoposide solution. In addition, white particles were discovered in CSTDs storing busulfan solution and small cracks were observed on devices which stored melphalan. Thus, it was concluded that even in simulated clinical conditions, instead of extreme conditions, there are still concerns regarding the efficacy and safety of CSTD components. The methodology may be used to implement and detect possible interactions between antineoplastic agents and CSTD components before procurement. FAU - Chiang, Shao-Chin AU - Chiang SC AUID- ORCID: 0000-0001-7906-467X AD - Department of Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. AD - Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. FAU - Shen, Mandy AU - Shen M AD - Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan. FAU - Lin, Chen-Chia AU - Lin CC AD - Department of Pharmacy, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. FAU - Chang, Hui-Ping AU - Chang HP AD - College of Nursing, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210928 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Antineoplastic Agents) SB - IM MH - Antineoplastic Agents/*adverse effects MH - Computer Simulation MH - Device Approval MH - Health Personnel MH - Humans MH - Male MH - Occupational Exposure/*prevention & control MH - Protective Devices PMC - PMC8478200 COIS- This work was supported by Needleless Corporation (Taiwan) (http://www.needleless-medical.com/en). We know of no conflict of interest associated that would influence the outcome of this publication. The funder had no role in the study design, data collection and analysis, and the decision to publish this manuscript. No grant number was attached to this study. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2021/09/29 06:00 MHDA- 2021/11/19 06:00 PMCR- 2021/09/28 CRDT- 2021/09/28 17:23 PHST- 2020/11/03 00:00 [received] PHST- 2021/09/14 00:00 [accepted] PHST- 2021/09/28 17:23 [entrez] PHST- 2021/09/29 06:00 [pubmed] PHST- 2021/11/19 06:00 [medline] PHST- 2021/09/28 00:00 [pmc-release] AID - PONE-D-20-34542 [pii] AID - 10.1371/journal.pone.0257873 [doi] PST - epublish SO - PLoS One. 2021 Sep 28;16(9):e0257873. doi: 10.1371/journal.pone.0257873. eCollection 2021. PMID- 13500224 OWN - NLM STAT- MEDLINE DCOM- 20000701 LR - 20250103 IS - 0008-1264 (Print) IS - 0008-1264 (Linking) VI - 88 IP - 2 DP - 1958 Feb TI - Employment of persons with epilepsy and heart disease. PG - 160-5 AB - Among persons who are often considered handicapped so far as employability is concerned are two groups deserving of special attention-persons with heart disease because of the ever-increasing number of them, and persons with epilepsy because of the extreme difficulty they have had in getting suitable jobs.A considerable number of persons with cardiac disease and a lesser number with epilepsy have been employed by the California Division of Lockheed Aircraft Corporation during the past ten years. It has been the experience there that the employment of such persons, once they are placed in jobs compatible with their physical limitations, has not resulted in unduly increasing the company's liability or labor cost and has not created operational problems of major proportions or jeopardized anyone's safety. Considerable research and effort are being expended by governmental and other agencies and associations to further enhance the safe placement of such persons. It is believed that these efforts, if coupled with realistic interpretation of the Workmen's Compensation Act in this regard, will bring about more liberal and widespread acceptance of persons with heart disease and epilepsy by industry. FAU - LORBEER, L T AU - LORBEER LT FAU - BARRON, C I AU - BARRON CI LA - eng PT - Journal Article PL - United States TA - Calif Med JT - California medicine JID - 0410260 SB - OM MH - California MH - *Persons with Disabilities MH - *Employment MH - *Epilepsy MH - *Heart Diseases MH - Humans MH - *Occupational Health MH - *Workers' Compensation PMC - PMC1512560 OID - CLML: 5833:43332:179:229:258 OTO - NLM OT - *EPILEPSY OT - *HEART DISEASES OT - *INDUSTRIAL HYGIENE EDAT- 1958/02/01 00:00 MHDA- 1958/02/01 00:01 PMCR- 1958/02/01 CRDT- 1958/02/01 00:00 PHST- 1958/02/01 00:00 [pubmed] PHST- 1958/02/01 00:01 [medline] PHST- 1958/02/01 00:00 [entrez] PHST- 1958/02/01 00:00 [pmc-release] PST - ppublish SO - Calif Med. 1958 Feb;88(2):160-5. PMID- 38915178 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240711 IS - 1523-7052 (Electronic) IS - 1523-7060 (Print) IS - 1523-7052 (Linking) VI - 26 IP - 26 DP - 2024 Jul 5 TI - Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation. PG - 5534-5538 LID - 10.1021/acs.orglett.4c01894 [doi] AB - The reduction of alkenes to their respective alkanes is one of the most important transformations in organic chemistry, given the abundance of natural and commercial olefins. Metal-catalyzed hydrogenation is the most common way to reduce alkenes; however, the use of H(2) gas in combination with the precious metals required for these conditions can be impractical, dangerous, and expensive. More complex substrates often require extremely high pressures of H(2), further emphasizing the safety concerns associated with these hydrogenation reactions. Here we report a safe, cheap, and practical photochemical alkene reduction using a readily available organophotocatalyst, catalytic thiol, and formate. These conditions reduce a variety of di-, tri-, and tetra-substituted alkenes in good yield as well as dearomatize pharmaceutically relevant heterocycles to generate sp(3)-rich isosteres of benzofurans and indoles. These formal-hydrogenation conditions tolerate a broad range of functionalities that would otherwise be sensitive to typical hydrogenations and are likely to be important for industry applications. FAU - Brzezinski, Carter U AU - Brzezinski CU AD - Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States. FAU - LeBlanc, Andrew R AU - LeBlanc AR AD - Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States. FAU - Clerici, Madeline G AU - Clerici MG AD - Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States. FAU - Wuest, William M AU - Wuest WM AUID- ORCID: 0000-0002-5198-7744 AD - Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States. LA - eng GR - R35 GM119426/GM/NIGMS NIH HHS/United States GR - TL1 DK136047/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20240624 PL - United States TA - Org Lett JT - Organic letters JID - 100890393 SB - IM PMC - PMC11232005 COIS- The authors declare no competing financial interest. EDAT- 2024/06/25 06:42 MHDA- 2024/06/25 06:43 PMCR- 2024/07/09 CRDT- 2024/06/25 01:03 PHST- 2024/06/25 06:43 [medline] PHST- 2024/06/25 06:42 [pubmed] PHST- 2024/06/25 01:03 [entrez] PHST- 2024/07/09 00:00 [pmc-release] AID - 10.1021/acs.orglett.4c01894 [doi] PST - ppublish SO - Org Lett. 2024 Jul 5;26(26):5534-5538. doi: 10.1021/acs.orglett.4c01894. Epub 2024 Jun 24. PMID- 31649663 OWN - NLM STAT- MEDLINE DCOM- 20201028 LR - 20201028 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 10 DP - 2019 TI - Determining Immune and miRNA Biomarkers Related to Respiratory Syncytial Virus (RSV) Vaccine Types. PG - 2323 LID - 10.3389/fimmu.2019.02323 [doi] LID - 2323 AB - Respiratory Syncytial Virus (RSV) causes serious respiratory tract illness and substantial morbidity and some mortality in populations at the extremes of age, i.e., infants, young children, and the elderly. To date, RSV vaccine development has been unsuccessful, a feature linked to the lack of biomarkers available to assess the safety and efficacy of RSV vaccine candidates. We examined microRNAs (miR) as potential biomarkers for different types of RSV vaccine candidates. In this study, mice were vaccinated with a live attenuated RSV candidate that lacks the small hydrophobic (SH) and attachment (G) proteins (CP52), an RSV G protein microparticle (GA2-MP) vaccine, a formalin-inactivated RSV (FI-RSV) vaccine or were mock-treated. Several immunological endpoints and miR expression profiles were determined in mouse serum and bronchoalveolar lavage (BAL) following vaccine priming, boost, and RSV challenge. We identified miRs that were linked with immunological parameters of disease and protection. We show that miRs are potential biomarkers providing valuable insights for vaccine development. CI - Copyright © 2019 Atherton, Jorquera, Bakre and Tripp. FAU - Atherton, Lydia J AU - Atherton LJ AD - Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States. FAU - Jorquera, Patricia A AU - Jorquera PA AD - Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States. FAU - Bakre, Abhijeet A AU - Bakre AA AD - Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States. FAU - Tripp, Ralph A AU - Tripp RA AD - Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191009 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) RN - 0 (MicroRNAs) RN - 0 (Respiratory Syncytial Virus Vaccines) SB - IM MH - Animals MH - Biomarkers MH - Female MH - *Immunization MH - Lung/*immunology/pathology MH - Mice MH - Mice, Inbred BALB C MH - MicroRNAs/*immunology MH - Respiratory Syncytial Virus Infections/immunology/prevention & control MH - Respiratory Syncytial Virus Vaccines/*immunology MH - Respiratory Syncytial Virus, Human/*immunology PMC - PMC6794384 OTO - NOTNLM OT - RSV OT - disease OT - immune OT - miR OT - microRNA OT - vaccines EDAT- 2019/10/28 06:00 MHDA- 2020/10/29 06:00 PMCR- 2019/01/01 CRDT- 2019/10/26 06:00 PHST- 2018/12/16 00:00 [received] PHST- 2019/09/13 00:00 [accepted] PHST- 2019/10/26 06:00 [entrez] PHST- 2019/10/28 06:00 [pubmed] PHST- 2020/10/29 06:00 [medline] PHST- 2019/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2019.02323 [doi] PST - epublish SO - Front Immunol. 2019 Oct 9;10:2323. doi: 10.3389/fimmu.2019.02323. eCollection 2019. PMID- 18182902 OWN - NLM STAT- MEDLINE DCOM- 20080328 LR - 20201209 IS - 1559-047X (Print) IS - 1559-047X (Linking) VI - 29 IP - 1 DP - 2008 Jan-Feb TI - An evaluation of the safety and efficacy of an anti-inflammatory, pulmonary enteral formula in the treatment of pediatric burn patients with respiratory failure. PG - 82-8 LID - 10.1097/BCR.0b013e31815f594e [doi] AB - Respiratory failure is associated with a high mortality rate in burned children. Recently, a specialized pulmonary enteral formula (SPEF) was commercially introduced as an adjunct intervention in acute lung injury management. SPEF contains condition-specific nutrients to modulate the inflammatory response. The study examined SPEF impact in critically ill, pediatric burn patients with respiratory failure. Medical records of acute burn patients admitted December 1997 to October 2006 were reviewed for SPEF treatment. Respiratory and renal indices were compared on the first and final days of SPEF use. Nineteen patients with respiratory failure received SPEF for a mean of 10.8 +/- 0.9 days during their acute burn course. Mean age was 5.3 +/- 1.5 years. Mean total body surface area burn was 44.3 +/- 5.4% with 32.5 +/- 6.4% full thickness. Patients were admitted 2.3 +/- 0.9 days postburn. Significant improvements in peak pressure, PEEP, FiO2, P:F ratio, Pco2, Po2, and ETco2 were noted. Seventeen of the 19 patients survived despite the fact that 9 of the 19 patients developed severe barotrauma requiring multiple tube thoracotomies, and all 19 had extremely poor prognoses at SPEF initiation. Adult SPEF formula for critically ill, pediatric burn patients with respiratory failure is safe and well tolerated. SPEF seems to facilitate recovery from acute lung injury as evidenced by improvements in oxygenation and pulmonary compliance. FAU - Mayes, Theresa AU - Mayes T AD - Department of Nutrition, Shriners Hospitals for Children, Cincinnati, Ohio 45229, USA. FAU - Gottschlich, Michele M AU - Gottschlich MM FAU - Kagan, Richard J AU - Kagan RJ LA - eng PT - Evaluation Study PT - Journal Article PL - England TA - J Burn Care Res JT - Journal of burn care & research : official publication of the American Burn Association JID - 101262774 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Acute Disease MH - Adolescent MH - Anti-Inflammatory Agents/adverse effects/*therapeutic use MH - Burns/drug therapy/mortality/*therapy MH - Child MH - Child Welfare MH - Child, Preschool MH - Critical Illness MH - Enteral Nutrition/*adverse effects MH - Fatty Acids, Omega-3 MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Lung Compliance MH - Male MH - Oxygenators MH - Respiratory Distress Syndrome/complications/*physiopathology MH - Retrospective Studies EDAT- 2008/01/10 09:00 MHDA- 2008/03/29 09:00 CRDT- 2008/01/10 09:00 PHST- 2008/01/10 09:00 [pubmed] PHST- 2008/03/29 09:00 [medline] PHST- 2008/01/10 09:00 [entrez] AID - 01253092-200801000-00012 [pii] AID - 10.1097/BCR.0b013e31815f594e [doi] PST - ppublish SO - J Burn Care Res. 2008 Jan-Feb;29(1):82-8. doi: 10.1097/BCR.0b013e31815f594e. PMID- 38270234 OWN - NLM STAT- MEDLINE DCOM- 20240214 LR - 20240603 IS - 1097-0274 (Electronic) IS - 0271-3586 (Print) IS - 0271-3586 (Linking) VI - 67 IP - 3 DP - 2024 Mar TI - Hired crop worker injury risks on farms in the United States during three different periods between 2002 and 2015. PG - 224-242 LID - 10.1002/ajim.23565 [doi] AB - BACKGROUND: Hired crop workers have high incidence of work-related injuries, but little has been documented about potential risks at the national level. METHODS: Data were obtained from a national probability sample of hired crop workers in the United States (U.S.) during 2002-2004 (period I), 2008-2010 (period II), and 2014-2015 (period III). Multivariable logistic regression models of work-related injury were constructed using an occupational exposure adjustment for weeks worked in the previous year. RESULTS: Hired crop workers reporting that their employer did not provide clean drinking water and disposable cups every day were estimated to be at greater odds of injury during all three periods. Having at least some English-speaking ability was associated with increased odds of injury in two periods, while owning a dwelling in the U.S. showed greater injury risk during period II but was associated with lower risk during period III. Other items significantly associated with injury during at least one of the study periods in the final multivariable logistic models included being a direct-hire, a migrant worker, U.S.-born, receiving public aid, and having a health condition. CONCLUSIONS: Hired crop workers are an extremely marginalized population of workers in the U.S. Innovative intervention methods must extend beyond traditional occupational models to focus on the overall health of hired crop workers, including increasing healthcare access, ending agricultural exceptionalism to provide equal regulatory protections afforded to workers in other industries, and adequate enforcement of existing regulations. These findings contribute to the understanding of correlates related to increased work-related injury among hired crop workers, and have implications in fields of prevention, intervention, and policy. CI - © 2024 Wiley Periodicals LLC. FAU - Layne, Larry A AU - Layne LA AD - Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, West Virginia, USA. FAU - Siordia, Carlos AU - Siordia C AD - National Center for Injury Prevention and Control (NCIPC), Centers for Disease Control and Prevention (CDC), Office of Program Management and Operations, Atlanta, Georgia, USA. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States PT - Journal Article DEP - 20240125 PL - United States TA - Am J Ind Med JT - American journal of industrial medicine JID - 8101110 SB - IM MH - Humans MH - United States/epidemiology MH - Farms MH - *Occupational Injuries/epidemiology/etiology MH - Agriculture MH - Delivery of Health Care MH - *Transients and Migrants PMC - PMC10961608 MID - NIHMS1973218 OTO - NOTNLM OT - Hispanic OT - farm worker OT - injury OT - migrant COIS- CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest. DISCLOSURE BY AJIM EDITOR OF RECORD John Meyer declares that he has no conflict of interest in the review and publication decision regarding this article. EDAT- 2024/01/25 12:42 MHDA- 2024/02/13 12:45 PMCR- 2024/06/01 CRDT- 2024/01/25 08:14 PHST- 2023/12/06 00:00 [revised] PHST- 2023/08/03 00:00 [received] PHST- 2024/01/08 00:00 [accepted] PHST- 2024/02/13 12:45 [medline] PHST- 2024/01/25 12:42 [pubmed] PHST- 2024/01/25 08:14 [entrez] PHST- 2024/06/01 00:00 [pmc-release] AID - 10.1002/ajim.23565 [doi] PST - ppublish SO - Am J Ind Med. 2024 Mar;67(3):224-242. doi: 10.1002/ajim.23565. Epub 2024 Jan 25. PMID- 1675817 OWN - NLM STAT- MEDLINE DCOM- 19910722 LR - 20131121 IS - 0040-5957 (Print) IS - 0040-5957 (Linking) VI - 46 IP - 2 DP - 1991 Mar-Apr TI - [Treatment of acute phase of myocardial infarction with injectable bisoprolol with oral versus]. PG - 147-54 AB - The early treatment of acute myocardial infarction with beta-blockers represents a major advance in the management of this condition which was proved in a large serie of international studies including a total of about 30,000 patients, and in recent overviews. As a whole such treatment reduces total mortality by 13 to 14% during the first week (p less than .02) in the treated group compared with the controls. The mortality reduction appears most marked in the first two days, about 25%, after early intravenous infusion. Data on non fatal reinfarction in hospital suggest that early treatment reduces this risk by about 19% (p less than .01). Furthermore data on all patients suffering deaths, non fatal arrest and non fatal reinfarction indicate a 16% reduction in the risk of suffering one of these major events (p less than .001) and provide strong evidence of the beneficial effect of this class. Bisoprolol (Detensiel) is a high beta 1-selective beta-adrenoceptor blocking agent without intrinsic sympathomimetric activity and local anaesthetic activity. Its pharmacokinetic profile appears extremely favourable with a plasma elimination half-life of about 10 h and a balanced clearance: bisoprolol is inactivated by liver metabolism (about 50%) and excreted unchanged in the urine (about 50%). Two pilot open studies were performed up to now with IV bisoprolol in acute myocardial infarction (MI). The first trial (n = 37) confirms the clinical and ECG safety of the administered dose regimen: repeated IV infusion of 1 mg up to a cumulative maximum dose of 5 mg and subsequent oral treatment with 10 mg once daily (o.d.).(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Grollier, G AU - Grollier G AD - Soins Intensifs Cardiologiques, CHU Côte de Nacre, Caen. FAU - Samoyeau, R AU - Samoyeau R FAU - Potier, J C AU - Potier JC LA - fre PT - Clinical Trial PT - English Abstract PT - Journal Article TT - Traitement de la phase aiguë de l'infarctus du myocarde par le bisoprolol injectable avec relais oral. PL - France TA - Therapie JT - Therapie JID - 0420544 RN - 0 (Adrenergic beta-Antagonists) RN - 0 (Propanolamines) RN - Y41JS2NL6U (Bisoprolol) SB - IM MH - Acute Disease MH - Administration, Oral MH - Adrenergic beta-Antagonists/*administration & dosage/therapeutic use MH - Aged MH - Bisoprolol MH - Drug Administration Schedule MH - Female MH - Humans MH - Injections, Intravenous MH - Male MH - Middle Aged MH - Myocardial Infarction/*drug therapy MH - Propanolamines/*administration & dosage/therapeutic use EDAT- 1991/03/01 00:00 MHDA- 1991/03/01 00:01 CRDT- 1991/03/01 00:00 PHST- 1991/03/01 00:00 [pubmed] PHST- 1991/03/01 00:01 [medline] PHST- 1991/03/01 00:00 [entrez] PST - ppublish SO - Therapie. 1991 Mar-Apr;46(2):147-54. PMID- 39712678 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250104 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 11 DP - 2024 Nov TI - Unusual Presentation of Non-Gestational Extragonadal Choriocarcinoma. PG - e74072 LID - 10.7759/cureus.74072 [doi] LID - e74072 AB - Non-gestational choriocarcinoma is an extremely rare and highly aggressive malignant tumor that arises independent of gestational events, making less than 0.6% of all ovarian germ cell tumors. Unlike the more common gestational choriocarcinoma, which is associated with pregnancy, non-gestational choriocarcinoma originates from germ cells within the ovary. It accounts for a small fraction of ovarian malignancies and is often characterized by elevated levels of serum beta-human chorionic gonadotropin (β-HCG). The rarity and clinical overlap with other ovarian tumors pose significant diagnostic challenges, necessitating a thorough histopathological and immunohistochemical examination for accurate diagnosis. A 39-year-old female presented with a two-week history of right-sided migraine and general malaise, followed by a three-day onset of vision loss in the right eye. Initial evaluation in the emergency department included a chest X-ray, which revealed a 10 cm rounded opacity in the upper lobe of the left lung. A CT scan of the head showed a 4.5 cm rim-enhancing lesion in the left occipital lobe, along with a left middle cerebral artery (MCA) aneurysm. Notably, her serum β-HCG levels were significantly elevated at 5,642 mIU/mL despite the absence of intrauterine or extrauterine pregnancy on abdominal and pelvic ultrasound. Further workup included a CT thorax and MRI of the brain, which confirmed the isolated lung mass and left occipital lobe mass with no other sites of disease, leading to her transfer to the neurosurgery department. The patient underwent a left occipital craniotomy with tumor resection. Histopathological analysis confirmed the diagnosis of choriocarcinoma. Chromosomal analysis showed no evidence of the Y chromosome and confirmed the non-gestational origin of the choriocarcinoma. This case report discusses the non-specific presentation, radiological features, current treatment options, and potential safety strategies for managing this rare condition. CI - Copyright © 2024, Gafar et al. FAU - Gafar, Islam AU - Gafar I AD - General Medicine, University Hospital Waterford, Waterford, IRL. FAU - Elhassan, Mohamed AU - Elhassan M AD - General Medicine, University Hospital Waterford, Waterford, IRL. FAU - Elhaj, Ammar AU - Elhaj A AD - General Medicine, University Hospital Waterford, Waterford, IRL. FAU - Calvert, Paula AU - Calvert P AD - Oncology, University Hospital Waterford, Waterford, IRL. LA - eng PT - Case Reports PT - Journal Article DEP - 20241120 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC11661879 OTO - NOTNLM OT - choriocarcinoma syndrome OT - extra gonadal choriocarcinoma OT - extra-gestational choriocarcinoma OT - extragenital choriocarcinoma OT - non-gestational choriocarcinoma COIS- Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2024/12/23 17:24 MHDA- 2024/12/23 17:25 PMCR- 2024/11/20 CRDT- 2024/12/23 06:09 PHST- 2024/11/20 00:00 [accepted] PHST- 2024/12/23 17:25 [medline] PHST- 2024/12/23 17:24 [pubmed] PHST- 2024/12/23 06:09 [entrez] PHST- 2024/11/20 00:00 [pmc-release] AID - 10.7759/cureus.74072 [doi] PST - epublish SO - Cureus. 2024 Nov 20;16(11):e74072. doi: 10.7759/cureus.74072. eCollection 2024 Nov. PMID- 6197726 OWN - NLM STAT- MEDLINE DCOM- 19840215 LR - 20191031 IS - 0273-2300 (Print) IS - 0273-2300 (Linking) VI - 3 IP - 4 DP - 1983 Dec TI - An overview of safety and regulatory aspects of the new biotechnology. PG - 428-33 AB - New technology is producing new drugs and biologic products that present novel safety issues for the regulatory agencies. These products are produced using recombinant DNA or hybridoma techniques. Examples are growth hormone, antihemophilic factor, and interferon, produced by recombinant DNA. Very special proteins, namely, monoclonal antibodies, can be made by hybridoma technology that are extremely pure and potent. At present over two dozen in vitro monoclonal antibody products are approved by FDA and many more are expected. Regulating these products posed some new questions for the FDA, regarding the kinds of safety tests that should be done to establish reasonable levels of safety before clinical trials or marketing of these agents. The production methods are novel and thus require careful consideration to ensure that risks inherent in those methods do not cause disease when these products are administered to human subjects. A general overview of the regulatory safety issues of these new products is given. FAU - Petricciani, J C AU - Petricciani JC LA - eng PT - Journal Article PL - Netherlands TA - Regul Toxicol Pharmacol JT - Regulatory toxicology and pharmacology : RTP JID - 8214983 RN - 0 (Antibodies, Monoclonal) RN - 0 (DNA, Recombinant) RN - 9008-11-1 (Interferons) SB - IM MH - *Antibodies, Monoclonal MH - *DNA, Recombinant MH - Humans MH - Interferons/biosynthesis/toxicity MH - Legislation as Topic MH - United States EDAT- 1983/12/01 00:00 MHDA- 1983/12/01 00:01 CRDT- 1983/12/01 00:00 PHST- 1983/12/01 00:00 [pubmed] PHST- 1983/12/01 00:01 [medline] PHST- 1983/12/01 00:00 [entrez] AID - 0273-2300(83)90013-2 [pii] AID - 10.1016/0273-2300(83)90013-2 [doi] PST - ppublish SO - Regul Toxicol Pharmacol. 1983 Dec;3(4):428-33. doi: 10.1016/0273-2300(83)90013-2. PMID- 36206028 OWN - NLM STAT- MEDLINE DCOM- 20230117 LR - 20230117 IS - 1557-7600 (Electronic) IS - 1096-620X (Linking) VI - 26 IP - 1 DP - 2023 Jan TI - Sweetly Improving Sugars? Reviewing Cinnamon's Effects on Blood Glucose. PG - 68-73 LID - 10.1089/jmf.2022.0073 [doi] AB - Cinnamon is a spice that has been used in various cultures for centuries for its potential health benefits. While there are health claims for a variety of health conditions, it has continuously been explored for its ability to improve glucose handling in diabetes. Cinnamon is a very popular supplement used by patients with diabetes to help normalize blood glucose levels. A systematic review of the literature was conducted to assess the available evidence evaluating effects on diabetes and glucose handling with the use of various species of cinnamon. The intention was to summarize the existing evidence for cinnamon's effects on blood glucose, both for safety and efficacy, to help guide providers and consumers alike. Reviewing the available literature for the different types of cinnamon and their effects on the diabetes disease process, there are multiple proposed mechanisms for how cinnamon could improve diabetes, including increasing insulin sensitivity by multiple receptor signaling pathways, reducing inflammation, enhancing glucose uptake by effects on glucose transporter proteins, and effects on gastric emptying, and blocking glucose absorption. There appears to be conflicting evidence on whether cinnamon produces any significant effect on glucose parameters, and the extent of these effects. There are several variables that could explain these conflicting data, such as patient sample size, doses and formulations of cinnamon used, baseline patient characteristics, and study duration. A more in-depth evaluation and rating of the available evidence could help clarify this, but data suggest that in some circumstances, cinnamon may have modest effects on improving glucose handling in adults. The safety profile also has been demonstrated to be extremely favorable, with very few adverse events reported in the active treatment groups across all studies. Based upon these data, clinicians should consider cinnamon to be a potential adjunctive therapy to traditional diabetes treatments, and should be open to discussing this with patients expressing interest in the supplement. FAU - Nuffer, Wesley AU - Nuffer W AUID- ORCID: 0000-0002-3355-4582 AD - Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA. FAU - Tall Bull, Shasta AU - Tall Bull S AD - Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA. FAU - Bakhach, Hebat AU - Bakhach H AD - Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA. FAU - Nuffer, Monika AU - Nuffer M AD - Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA. LA - eng PT - Journal Article PT - Review DEP - 20221007 PL - United States TA - J Med Food JT - Journal of medicinal food JID - 9812512 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) RN - 0 (Sugars) SB - IM MH - Adult MH - Humans MH - *Blood Glucose/metabolism MH - *Diabetes Mellitus, Type 2/drug therapy MH - Cinnamomum zeylanicum MH - Glycated Hemoglobin MH - Sugars/therapeutic use MH - Phytotherapy OTO - NOTNLM OT - blood glucose OT - cinnamon OT - diabetes OT - hemoglobin A1C OT - sugars EDAT- 2022/10/08 06:00 MHDA- 2023/01/18 06:00 CRDT- 2022/10/07 11:43 PHST- 2022/10/08 06:00 [pubmed] PHST- 2023/01/18 06:00 [medline] PHST- 2022/10/07 11:43 [entrez] AID - 10.1089/jmf.2022.0073 [doi] PST - ppublish SO - J Med Food. 2023 Jan;26(1):68-73. doi: 10.1089/jmf.2022.0073. Epub 2022 Oct 7. PMID- 21214621 OWN - NLM STAT- MEDLINE DCOM- 20110629 LR - 20220317 IS - 1365-2648 (Electronic) IS - 0309-2402 (Linking) VI - 67 IP - 4 DP - 2011 Apr TI - Heatwaves and their impact on people with alcohol, drug and mental health conditions: a discussion paper on clinical practice considerations. PG - 915-22 LID - 10.1111/j.1365-2648.2010.05551.x [doi] AB - AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for people with mental health disorders, substance misuse and those taking prescribed medications such as lithium, various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include heat stroke and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with mental health disorders and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those people with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of alcohol and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves. CI - © 2011 The Authors. Journal of Advanced Nursing © 2011 Blackwell Publishing Ltd. FAU - Cusack, Lynette AU - Cusack L AD - School of Nursing and Midwifery, Faculty of Health Science, Flinders University, Adelaide, South Australia, Australia. lynette.cusack@flinders.edu.au FAU - de Crespigny, Charlotte AU - de Crespigny C FAU - Athanasos, Peter AU - Athanasos P LA - eng PT - Journal Article DEP - 20110107 PL - England TA - J Adv Nurs JT - Journal of advanced nursing JID - 7609811 RN - 0 (Psychotropic Drugs) SB - IM MH - Alcohol Drinking/adverse effects MH - Australia/epidemiology MH - Body Temperature Regulation/drug effects/physiology MH - Chronic Disease MH - *Clinical Protocols MH - Comorbidity MH - *Disaster Medicine MH - Emergency Medical Services/statistics & numerical data MH - Female MH - Global Warming MH - Heat Stress Disorders/*epidemiology/etiology/nursing MH - Hot Temperature/*adverse effects MH - Humans MH - Infant MH - Male MH - Mental Disorders/drug therapy/*epidemiology/nursing MH - Nurse's Role MH - Patient Education as Topic MH - Psychotropic Drugs/adverse effects MH - Risk Factors MH - Substance Withdrawal Syndrome/drug therapy/etiology MH - Substance-Related Disorders/*epidemiology/nursing/physiopathology EDAT- 2011/01/11 06:00 MHDA- 2011/06/30 06:00 CRDT- 2011/01/11 06:00 PHST- 2011/01/11 06:00 [entrez] PHST- 2011/01/11 06:00 [pubmed] PHST- 2011/06/30 06:00 [medline] AID - 10.1111/j.1365-2648.2010.05551.x [doi] PST - ppublish SO - J Adv Nurs. 2011 Apr;67(4):915-22. doi: 10.1111/j.1365-2648.2010.05551.x. Epub 2011 Jan 7. PMID- 34208426 OWN - NLM STAT- MEDLINE DCOM- 20210721 LR - 20210724 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 18 IP - 12 DP - 2021 Jun 16 TI - Forgotten Contributors in the Brick Sector in Nepal. LID - 10.3390/ijerph18126479 [doi] LID - 6479 AB - Brick making in Nepal is an informal sector that is still highly labor intensive. It employs transient workers who are extremely marginalized and exposed to poor working and living conditions. This study assesses the working and living conditions of male and female brick workers and their children and looks to address the main issues and challenges to promote decent living and working conditions in the brick factories through action research. A rapid needs assessment was conducted to take stock of the working and living conditions of male and female workers across five provinces in Nepal. Subsequently, selected pilot interventions through stakeholder consultations were initiated to address these issues and challenges. There are a host of challenges faced by these workers in the factories, with the main issues being occupational health and safety and childcare/education for workers' children. The study suggests that the working and living conditions of the workers can be improved by incentivizing the brick entrepreneurs to invest in them, thus creating a more productive workforce. Moreover, the findings from the pilot interventions can help in the design of effective solutions. FAU - Bajracharya, Sugat B AU - Bajracharya SB AUID- ORCID: 0000-0002-7944-205X AD - International Centre for Integrated Mountain Development, Lalitpur, G.P.O. Box 3226, Kathmandu 44700, Nepal. FAU - Gurung, Kamala AU - Gurung K AD - International Centre for Integrated Mountain Development, Lalitpur, G.P.O. Box 3226, Kathmandu 44700, Nepal. FAU - Mathema, Luja AU - Mathema L AD - International Centre for Integrated Mountain Development, Lalitpur, G.P.O. Box 3226, Kathmandu 44700, Nepal. FAU - Sharma, Sanjay AU - Sharma S AD - International Centre for Integrated Mountain Development, Lalitpur, G.P.O. Box 3226, Kathmandu 44700, Nepal. FAU - Mishra, Arabinda AU - Mishra A AD - International Centre for Integrated Mountain Development, Lalitpur, G.P.O. Box 3226, Kathmandu 44700, Nepal. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210616 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Child MH - Employment MH - Female MH - Humans MH - Informal Sector MH - Male MH - Nepal MH - *Occupational Health PMC - PMC8296312 OTO - NOTNLM OT - brick sector in Nepal OT - decent working and living conditions OT - informal sector OT - informal workers OT - rapid needs assessment COIS- The authors declare no conflict of interest. EDAT- 2021/07/03 06:00 MHDA- 2021/07/22 06:00 PMCR- 2021/06/16 CRDT- 2021/07/02 01:34 PHST- 2021/05/05 00:00 [received] PHST- 2021/05/21 00:00 [accepted] PHST- 2021/07/02 01:34 [entrez] PHST- 2021/07/03 06:00 [pubmed] PHST- 2021/07/22 06:00 [medline] PHST- 2021/06/16 00:00 [pmc-release] AID - ijerph18126479 [pii] AID - ijerph-18-06479 [pii] AID - 10.3390/ijerph18126479 [doi] PST - epublish SO - Int J Environ Res Public Health. 2021 Jun 16;18(12):6479. doi: 10.3390/ijerph18126479. PMID- 32984830 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220417 IS - 2639-8028 (Electronic) IS - 2639-8028 (Linking) VI - 2 IP - 9 DP - 2020 Sep TI - Inline Positive End-Expiratory Pressure Valves: The Essential Component of Individualized Split Ventilator Circuits. PG - e0198 LID - 10.1097/CCE.0000000000000198 [doi] LID - e0198 AB - BACKGROUND: As resources are overwhelmed with the coronavirus disease 2019 pandemic, multiple approaches to produce individualized split-ventilator designs have emerged. These designs attempt to address the significant limitations and safety concerns of coventilation practices by allowing practitioners to adjust pressure settings for individual patients connected with specialized circuits to a single ventilator. The critical component in virtually all individualized circuit designs is the adjustable inline positive end-expiratory pressure valve. METHODS: We reviewed the literature on the mechanics of inline positive end-expiratory pressure valve function, the implications and considerations for advanced application of inline positive end-expiratory pressure valves in individualized circuits, available methods of adapting commercial positive end-expiratory pressure valves in the resource-restricted setting, and major caveats of the use of inline positive end-expiratory pressure valves. RESULTS AND CONCLUSIONS: The function of adjustable inline positive end-expiratory pressure valves in advanced individualized ventilator circuits has not been described. Adjustable inline positive end-expiratory pressure valves are critical to individualized circuit reliability and patient safety when attempting to extend ventilator capacity in the setting of extreme ventilator shortages. Adjustable inline positive end-expiratory pressure valves provide a means to reduce delivered peak inspiratory pressure to an individual patient circuit, a method to increase positive end-expiratory pressure for an individual patient circuit, and act as an one-way valve to ensure unidirectional gas flow through the divided circuit. Adjustable inline positive end-expiratory pressure valves can be adapted from commercial valves or printed de novo when commercial options are unavailable. Noncommercial sourcing of ventilator components should only be considered in the setting of extreme ventilator shortages under the supervision of a knowledgeable anesthesiologist or intensivist. CI - Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. FAU - Roy, Steven AU - Roy S AD - Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. FAU - Bunting, Leonard AU - Bunting L AD - Department of Emergency Medicine, Wayne State University, Detroit, MI. AD - Department of Emergency Medicine, Ascension Providence Hospital, Southfield, MI. FAU - Stahl, Stefan AU - Stahl S AD - Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada. AD - Department of Emergency Medicine, Wayne State University, Detroit, MI. AD - Department of Emergency Medicine, Ascension Providence Hospital, Southfield, MI. AD - Institute of Mechanical Systems, ZHAW Zurich University of Applied Sciences, Winterthur, Switzerland. FAU - Textor, Dominik AU - Textor D AD - Institute of Mechanical Systems, ZHAW Zurich University of Applied Sciences, Winterthur, Switzerland. LA - eng PT - Journal Article DEP - 20200915 PL - United States TA - Crit Care Explor JT - Critical care explorations JID - 101746347 PMC - PMC7498127 OTO - NOTNLM OT - artificial respiration OT - coronavirus disease 2019 OT - mechanical ventilation OT - positive end-expiratory pressure OT - ventilator COIS- The authors have not disclosed any potential conflicts of interest. EDAT- 2020/09/29 06:00 MHDA- 2020/09/29 06:01 PMCR- 2020/09/15 CRDT- 2020/09/28 05:48 PHST- 2020/09/28 05:48 [entrez] PHST- 2020/09/29 06:00 [pubmed] PHST- 2020/09/29 06:01 [medline] PHST- 2020/09/15 00:00 [pmc-release] AID - 10.1097/CCE.0000000000000198 [doi] PST - epublish SO - Crit Care Explor. 2020 Sep 15;2(9):e0198. doi: 10.1097/CCE.0000000000000198. eCollection 2020 Sep. PMID- 26169744 OWN - NLM STAT- MEDLINE DCOM- 20160405 LR - 20150714 IS - 1940-6029 (Electronic) IS - 1064-3745 (Linking) VI - 1331 DP - 2015 TI - Glycoconjugate Vaccines: The Regulatory Framework. PG - 229-51 LID - 10.1007/978-1-4939-2874-3_14 [doi] AB - Most vaccines, including the currently available glycoconjugate vaccines, are administered to healthy infants, to prevent future disease. The safety of a prospective vaccine is a key prerequisite for approval. Undesired side effects would not only have the potential to damage the individual infant but also lead to a loss of confidence in the respective vaccine-or vaccines in general-on a population level. Thus, regulatory requirements, particularly with regard to safety, are extremely rigorous. This chapter highlights regulatory aspects on carbohydrate-based vaccines with an emphasis on analytical approaches to ensure the consistent quality of successive manufacturing lots. FAU - Jones, Christopher AU - Jones C AD - Laboratory for Molecular Structure, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, UK, chrisjones715@btinternet.com. LA - eng PT - Journal Article PL - United States TA - Methods Mol Biol JT - Methods in molecular biology (Clifton, N.J.) JID - 9214969 RN - 0 (Glycoconjugates) RN - 0 (Vaccines) SB - IM MH - Cell Line MH - Glycoconjugates/*immunology/*standards MH - Humans MH - Infant MH - Vaccines/*immunology/*standards EDAT- 2015/07/15 06:00 MHDA- 2016/04/06 06:00 CRDT- 2015/07/15 06:00 PHST- 2015/07/15 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2016/04/06 06:00 [medline] AID - 10.1007/978-1-4939-2874-3_14 [doi] PST - ppublish SO - Methods Mol Biol. 2015;1331:229-51. doi: 10.1007/978-1-4939-2874-3_14. PMID- 39275497 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240916 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 24 IP - 17 DP - 2024 Aug 28 TI - LiDAR-Based Snowfall Level Classification for Safe Autonomous Driving in Terrestrial, Maritime, and Aerial Environments. LID - 10.3390/s24175587 [doi] LID - 5587 AB - Studies on autonomous driving have started to focus on snowy environments, and studies to acquire data and remove noise and pixels caused by snowfall in such environments are in progress. However, research to determine the necessary weather information for the control of unmanned platforms by sensing the degree of snowfall in real time has not yet been conducted. Therefore, in this study, we attempted to determine snowfall information for autonomous driving control in snowy weather conditions. To this end, snowfall data were acquired by LiDAR sensors in various snowy areas in South Korea, Sweden, and Denmark. Snow, which was extracted using a snow removal filter (the LIOR filter that we previously developed), was newly classified and defined based on the extracted number of snow particles, the actual snowfall total, and the weather forecast at the time. Finally, we developed an algorithm that extracts only snow in real time and then provides snowfall information to an autonomous driving system. This algorithm is expected to have a similar effect to that of actual controllers in promoting driving safety in real-time weather conditions. FAU - Park, Ji-Il AU - Park JI AUID- ORCID: 0000-0002-4033-7965 AD - National Defense AI Center, Agency for Defense Development (ADD), 160, Bugyuseong-daero 488beon-gil, Yuseong-gu, Daejeon 34060, Republic of Korea. FAU - Jo, Seunghyeon AU - Jo S AUID- ORCID: 0009-0009-9317-2568 AD - AUTOCRYPT GmbH, Salvatorplatz, 80333 München, Germany. FAU - Seo, Hyung-Tae AU - Seo HT AUID- ORCID: 0000-0001-9717-344X AD - Department of Mechanical Engineering, College of Creative Engineering, Kyonggi University, 154-42, Gwanggyosan-ro, Suwon 16227, Republic of Korea. FAU - Park, Jihyuk AU - Park J AUID- ORCID: 0000-0001-7516-3398 AD - Department of Automotive Engineering, College of Digital Convergence, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, Republic of Korea. LA - eng GR - 220A580068/Yeungnam University/ GR - Development of Smart Port Autonomous Ship Linkage Technology/Ministry of Oceans and Fisheries/ PT - Journal Article DEP - 20240828 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM PMC - PMC11397817 OTO - NOTNLM OT - LIOR filter OT - LiDAR point cloud OT - extreme weather OT - snowfall level COIS- Seunghyeon Jo was employed by AUTOCRYPT GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/09/14 10:42 MHDA- 2024/09/14 10:43 PMCR- 2024/08/28 CRDT- 2024/09/14 01:20 PHST- 2024/06/22 00:00 [received] PHST- 2024/08/19 00:00 [revised] PHST- 2024/08/22 00:00 [accepted] PHST- 2024/09/14 10:43 [medline] PHST- 2024/09/14 10:42 [pubmed] PHST- 2024/09/14 01:20 [entrez] PHST- 2024/08/28 00:00 [pmc-release] AID - s24175587 [pii] AID - sensors-24-05587 [pii] AID - 10.3390/s24175587 [doi] PST - epublish SO - Sensors (Basel). 2024 Aug 28;24(17):5587. doi: 10.3390/s24175587. PMID- 12470529 OWN - NLM STAT- MEDLINE DCOM- 20030130 LR - 20190916 IS - 1472-6483 (Print) IS - 1472-6483 (Linking) VI - 5 IP - 3 DP - 2002 Nov-Dec TI - Current features of preimplantation genetic diagnosis. PG - 294-9 AB - More than 4000 preimplantation genetic diagnosis (PGD) cycles have been performed, suggesting that PGD may no longer be considered a research activity. The important present feature of PGD is its expansion to a variety of conditions, which have never been considered as an indication for prenatal diagnosis, including the late-onset disorders with genetic predisposition and preimplantation non-disease testing, with the further improvement of the accuracy of PGD for single gene disorders. PGD has also become a useful tool for the improvement of the effectiveness of IVF, through avoiding the transfer of chromosomally abnormal embryos, representing more than half of the embryos routinely transferred in IVF patients of advanced maternal age and other poor prognosis patients. PGD is of particular hope for the carriers of balanced chromosomal translocations, as it allows accurate pre-selection of a few balanced or normal embryos resulting from the extremely poor meiotic outcome, especially in reciprocal translocations. With the current progress in polymerase chain reaction- (PCR-) based detection of chromosomal abnormalities in oocytes and embryos, PGD may soon be performed for both chromosomal and single gene disorders using the same biopsied polar body or blastomere, frequently required with the currently expanded PGD application. The available clinical outcome data of more than 3000 PGD embryo transfers further suggest an acceptable pregnancy rate and safety of the procedure, as demonstrated by the follow-up information available for more than 500 children born from these PGD transfers. FAU - Kuliev, Anver AU - Kuliev A AD - Reproductive Genetics Institute, 2825 North Halsted Street, Chicago, IL 60657, USA. anverkuliev@hotmail.com FAU - Verlinsky, Yury AU - Verlinsky Y LA - eng PT - Journal Article PT - Review PL - Netherlands TA - Reprod Biomed Online JT - Reproductive biomedicine online JID - 101122473 SB - IM MH - Chromosome Aberrations MH - DNA Mutational Analysis MH - Female MH - Fertilization in Vitro MH - Genetic Diseases, Inborn/diagnosis/genetics MH - Histocompatibility Testing MH - Humans MH - Infant, Newborn MH - Male MH - Polymerase Chain Reaction MH - Pregnancy MH - Preimplantation Diagnosis/*trends MH - Reproductive Techniques, Assisted RF - 48 EDAT- 2002/12/10 04:00 MHDA- 2003/01/31 04:00 CRDT- 2002/12/10 04:00 PHST- 2002/12/10 04:00 [pubmed] PHST- 2003/01/31 04:00 [medline] PHST- 2002/12/10 04:00 [entrez] AID - S1472-6483(10)61835-4 [pii] AID - 10.1016/s1472-6483(10)61835-4 [doi] PST - ppublish SO - Reprod Biomed Online. 2002 Nov-Dec;5(3):294-9. doi: 10.1016/s1472-6483(10)61835-4. PMID- 15184837 OWN - NLM STAT- MEDLINE DCOM- 20040720 LR - 20181130 IS - 1530-6550 (Print) IS - 1530-6550 (Linking) VI - 5 Suppl 1 DP - 2004 TI - Practical considerations for switching beta-blockers in heart failure patients. PG - S36-44 AB - The use of beta-blocker therapy has proven extremely useful in a variety of clinical settings, including the management of hypertension, acute- and post-myocardial infarction, and in congestive heart failure (HF). However, there are noticeable differences among individual beta-blockers in regard to efficacy of treatment and clinical outcomes in many of these conditions. These differences are particularly apparent in the treatment of HF, where effects on reverse remodeling and interactions on the periphery are potential factors that can differentiate between the efficacy of one drug versus another. In fact, beta-blockers are not a singular, homogeneous group, but rather a class made up of a number of agents with individual differences in pharmacology, receptor biology, hemodynamic effects, and tolerability. In the event of ongoing disease progression, the onus of choosing the most appropriate beta-blocker falls on the clinician's shoulders. Given the baseline differences among medications of this class, the rationale and manner for transitioning to a different beta-blocker should take into account the specific receptor-blockade subtype of any given agent, as well as any other intrinsic effects attributed to a specific drug. This article includes 2 protocols for switching between carvedilol, a third generation non-selective agent with vasodilatory properties through a1-blockade, and a beta1-selective agent (e.g., metoprolol, atenolol). The aim is to simplify and maximize the safety and tolerability of performing this exchange. With the increasing amount of clinical evidence supporting the use of one beta-blocker over another in the treatment of HF, it behooves physicians treating this patient population to utilize the adrenergic blocking agent that provides optimal therapy with minimal side effects and intolerability. FAU - Abraham, William T AU - Abraham WT AD - Division of Cardiovascular Medicine, Davis Heart & Lung Research Institute, Ohio State University Heart Center, Columbus, Ohio, USA. FAU - Iyengar, Srinivas AU - Iyengar S LA - eng PT - Journal Article PT - Review PL - Singapore TA - Rev Cardiovasc Med JT - Reviews in cardiovascular medicine JID - 100960007 RN - 0 (Adrenergic beta-Antagonists) RN - 0 (Carbazoles) RN - 0 (Propanolamines) RN - 0K47UL67F2 (Carvedilol) SB - IM MH - Adrenergic beta-Antagonists/pharmacology/*therapeutic use MH - Carbazoles/pharmacology/*therapeutic use MH - Carvedilol MH - Heart Failure/*drug therapy MH - Humans MH - Propanolamines/pharmacology/*therapeutic use RF - 74 EDAT- 2004/06/09 05:00 MHDA- 2004/07/21 05:00 CRDT- 2004/06/09 05:00 PHST- 2004/06/09 05:00 [pubmed] PHST- 2004/07/21 05:00 [medline] PHST- 2004/06/09 05:00 [entrez] PST - ppublish SO - Rev Cardiovasc Med. 2004;5 Suppl 1:S36-44. PMID- 30043413 OWN - NLM STAT- MEDLINE DCOM- 20190613 LR - 20190613 IS - 1875-9114 (Electronic) IS - 0277-0008 (Linking) VI - 38 IP - 9 DP - 2018 Sep TI - FDA Breakthrough Therapy Designation: Evaluating the Quality of the Evidence behind the Drug Approvals. PG - 967-980 LID - 10.1002/phar.2167 [doi] AB - The United States Food and Drug Administration (FDA) has created approval pathways and designations to accelerate access to medications indicated for serious or life-threatening conditions with limited treatment options. Implemented in 2012, the most recent of these is the breakthrough therapy designation (BTD). The purpose of this article was to review the evidence surrounding approval of medications with nononcology indications approved with the BTD designation from 2012 to 2016. Fifteen medications were identified for eight conditions, ranging from conditions that are relatively common, such as chronic hepatitis C infection, to those that are extremely rare, such as lysosomal acid lipase deficiency. The quality of evidence behind these approvals was highly heterogeneous. Much remains unknown about the safety and efficacy of many agents approved through the BTD. Health care professionals should be aware of these limitations to better educate patients and other providers appropriately. CI - © 2018 Pharmacotherapy Publications, Inc. FAU - Herink, Megan C AU - Herink MC AUID- ORCID: 0000-0001-6402-0260 AD - Department of Pharmacy Practice, Oregon State University/Oregon Health & Science University College of Pharmacy, Portland, Oregon. FAU - Irwin, Adriane N AU - Irwin AN AUID- ORCID: 0000-0002-2086-4493 AD - Department of Pharmacy Practice, Oregon State University/Oregon Health & Science University College of Pharmacy, Corvallis, Oregon. FAU - Zumach, Gregory M AU - Zumach GM AD - Department of Pharmacy Practice, Oregon State University/Oregon Health & Science University College of Pharmacy, Corvallis, Oregon. LA - eng PT - Journal Article PT - Review PL - United States TA - Pharmacotherapy JT - Pharmacotherapy JID - 8111305 SB - IM MH - Critical Illness/*therapy MH - *Drug Approval MH - Humans MH - Rare Diseases/*drug therapy MH - Time Factors MH - United States MH - United States Food and Drug Administration/*standards/*statistics & numerical data OTO - NOTNLM OT - BTD OT - FDA OT - U.S. Food and Drug Administration OT - accelerated approval OT - breakthrough therapy designation OT - drug safety OT - rare diseases EDAT- 2018/07/26 06:00 MHDA- 2019/06/14 06:00 CRDT- 2018/07/26 06:00 PHST- 2018/07/26 06:00 [pubmed] PHST- 2019/06/14 06:00 [medline] PHST- 2018/07/26 06:00 [entrez] AID - 10.1002/phar.2167 [doi] PST - ppublish SO - Pharmacotherapy. 2018 Sep;38(9):967-980. doi: 10.1002/phar.2167. PMID- 36548784 OWN - NLM STAT- MEDLINE DCOM- 20221226 LR - 20230125 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 14 IP - 12 DP - 2022 Dec 19 TI - Assessment of Maize Hybrids Resistance to Aspergillus Ear Rot and Aflatoxin Production in Environmental Conditions in Serbia. LID - 10.3390/toxins14120887 [doi] LID - 887 AB - Aflatoxin, a naturally occurring toxin produced by the fungus Aspergillus flavus, is the most economically important mycotoxin in the world, with harmful effects on human and animal health. Preventive measures such as irrigation and planting dates can minimize aflatoxin contamination most years. However, no control strategy is completely effective when environmental conditions are extremely favorable for growth of the fungus. The most effective control method is growing maize hybrids with genetic resistance to aflatoxin contamination. The aim of this research was to evaluate the sensitivity of different maize hybrids to A. flavus infection and aflatoxin accumulation. Twenty commercial maize hybrids were evaluated in field trials with artificial inoculations using the colonized toothpicks method. The mycotoxin production potential of A. flavus isolates was confirmed by cluster amplification patterns (CAPs) analysis. The results of this research indicated the existence of significant differences in maize hybrids susceptibility to Aspergillus ear rot and aflatoxin B(1) accumulation. No hybrid included in this research showed complete resistance in all conditions, but some hybrids showed partial resistance. Different hybrids also responded differently depending on the sowing date. This research showed that infection intensity is not always consistent with aflatoxin levels, and therefore visual evaluation is not enough to assess maize safety. FAU - Barošević, Tijana AU - Barošević T AUID- ORCID: 0000-0002-6103-8024 AD - BioSense Institute, University of Novi Sad, 21000 Novi Sad, Serbia. FAU - Bagi, Ferenc AU - Bagi F AUID- ORCID: 0000-0002-8646-1072 AD - Faculty of Agriculture, University of Novi Sad, 21000 Novi Sad, Serbia. FAU - Savić, Zagorka AU - Savić Z AD - Faculty of Agriculture, University of Novi Sad, 21000 Novi Sad, Serbia. FAU - Ljubičić, Nataša AU - Ljubičić N AUID- ORCID: 0000-0001-5982-9401 AD - BioSense Institute, University of Novi Sad, 21000 Novi Sad, Serbia. FAU - Ivanović, Ivana AU - Ivanović I AUID- ORCID: 0000-0002-0929-8865 AD - Faculty of Agriculture, University of Novi Sad, 21000 Novi Sad, Serbia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221219 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 0 (Aflatoxins) SB - IM MH - Animals MH - Humans MH - *Aflatoxins/analysis MH - Zea mays/genetics/microbiology MH - Serbia MH - Aspergillus/genetics MH - Aspergillus flavus/genetics PMC - PMC9781229 OTO - NOTNLM OT - Aspergillus ear rot OT - Aspergillus flavus OT - aflatoxin OT - artificial inoculation OT - food safety OT - maize hybrids OT - resistance COIS- The authors declare no conflict of interest. EDAT- 2022/12/23 06:00 MHDA- 2022/12/27 06:00 PMCR- 2022/12/19 CRDT- 2022/12/22 15:13 PHST- 2022/11/19 00:00 [received] PHST- 2022/12/11 00:00 [revised] PHST- 2022/12/13 00:00 [accepted] PHST- 2022/12/22 15:13 [entrez] PHST- 2022/12/23 06:00 [pubmed] PHST- 2022/12/27 06:00 [medline] PHST- 2022/12/19 00:00 [pmc-release] AID - toxins14120887 [pii] AID - toxins-14-00887 [pii] AID - 10.3390/toxins14120887 [doi] PST - epublish SO - Toxins (Basel). 2022 Dec 19;14(12):887. doi: 10.3390/toxins14120887. PMID- 37431240 OWN - NLM STAT- MEDLINE DCOM- 20231227 LR - 20231227 IS - 1549-7879 (Electronic) IS - 1522-6514 (Linking) VI - 26 IP - 2 DP - 2024 TI - Biosorption of hexavalent chromium and molybdenum ions using extremophilic cyanobacterial mats: efficiency, isothermal, and kinetic studies. PG - 228-240 LID - 10.1080/15226514.2023.2232878 [doi] AB - Two extremophilic cyanobacterial-bacterial consortiums naturally grow in extreme habitats of high temperature and hypersaline were used to remediate hexavalent chromium and molybdenum ions. Extremophilic cyanobacterial-bacterial biomasses were collected from Zeiton and Aghormi Lakes in the Western Desert, Egypt, and were applied as novel and promising natural adsorbents for hexavalent chromium and molybdenum. Some physical characterizations of biosorbent surfaces were described using scanning electron microscope, energy-dispersive X-ray spectroscopy, Fourier transformation infrared spectroscopy, and surface area measure. The maximum removal efficiencies of both biosorbents were 15.62-22.72 mg/g for Cr(VI) and 42.15-46.29 mg/g for Mo(VI) at optimum conditions of pH 5, adsorbent biomass of 2.5-3.0 g/L, and 150 min contact time. Langmuir and Freundlich adsorption models were better fit for Cr(VI), whereas Langmuir model was better fit than the Freundlich model for Mo(VI) biosorption. The kinetic results revealed that the adsorption reaction obeyed the pseudo-second-order model confirming a chemisorption interaction between microbial films and the adsorbed metals. Zeiton biomass exhibited a relatively higher affinity for removing Cr(VI) than Aghormi biomass but a lower affinity for Mo(VI) removal. The results showed that these extremophiles are novel and promising candidates for toxic metal remediation. FAU - Al-Qahtani, Khairia M AU - Al-Qahtani KM AUID- ORCID: 0000-0001-6542-2683 AD - Chemistry Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Abd Elkarim, Mohamad S AU - Abd Elkarim MS AUID- ORCID: 0000-0002-8570-3578 AD - Hydrobiology Department, National Institute of Oceanography & Fisheries, Cairo, Egypt. FAU - Al-Fawzan, Foziah F AU - Al-Fawzan FF AUID- ORCID: 0000-0001-6450-2219 AD - Chemistry Department, Faculty of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Al-Afify, Afify D G AU - Al-Afify ADG AUID- ORCID: 0000-0002-9316-683X AD - Chemistry Department, National Institute of Oceanography & Fisheries, Cairo, Egypt. FAU - Ali, Mohamed H H AU - Ali MHH AUID- ORCID: 0000-0003-0141-7791 AD - Chemistry Department, National Institute of Oceanography & Fisheries, Cairo, Egypt. LA - eng PT - Journal Article DEP - 20230711 PL - United States TA - Int J Phytoremediation JT - International journal of phytoremediation JID - 101136878 RN - 18540-29-9 (chromium hexavalent ion) RN - 81AH48963U (Molybdenum) RN - 0R0008Q3JB (Chromium) RN - 0 (Ions) RN - 0 (Water Pollutants, Chemical) SB - IM MH - Molybdenum MH - *Extremophiles MH - Kinetics MH - Biodegradation, Environmental MH - Chromium/chemistry MH - *Cyanobacteria MH - Adsorption MH - Ions MH - Hydrogen-Ion Concentration MH - *Water Pollutants, Chemical/analysis OAB - Even though many researchers worked on the field of metal bioremediation, most use single organism or extracted biogenic materials for heavy metals removal. The novelty of this study is the application of a consortium of cyanobacteria and bacteria from extreme habitats (hyper-salinity, high temperature, harsh weather conditions, high intensity of light and UV light) in the field of environmental safety. This specialized microbial film composed of a diverse group of adapted organisms that co-operate between each other making them more effective bio-remediating agent. This study examined the effectiveness of these consortia as metals bioremediator and cover the gap of research results from the scarce application of novel, cheap and eco-friendly extremophiles in toxic metals removal. OABL- eng OTO - NOTNLM OT - Biosorption OT - chromium OT - extreme habitat OT - extremophilic mats OT - molybdenum EDAT- 2023/07/11 06:42 MHDA- 2023/12/27 06:42 CRDT- 2023/07/11 03:13 PHST- 2023/12/27 06:42 [medline] PHST- 2023/07/11 06:42 [pubmed] PHST- 2023/07/11 03:13 [entrez] AID - 10.1080/15226514.2023.2232878 [doi] PST - ppublish SO - Int J Phytoremediation. 2024;26(2):228-240. doi: 10.1080/15226514.2023.2232878. Epub 2023 Jul 11. PMID- 18570757 OWN - NLM STAT- MEDLINE DCOM- 20080811 LR - 20191210 IS - 0392-856X (Print) IS - 0392-856X (Linking) VI - 26 IP - 1 Suppl 48 DP - 2008 Jan-Feb TI - Infections and treatment of patients with rheumatic diseases. PG - S67-73 AB - Glucocorticoids (GCs) have many complex quantitative and qualitative immunosuppressive effects which induce cellular immunodeficiency and increase host susceptibility to various viral, bacterial, fungal and parasitic infections. As cortisol secretion is inadequate in chronic immune/inflammatory conditions, and current therapies have the aim of providing adequate (low) compensatory doses, the timing of GC administration, such as during the nocturnal turning-on phase of tumour necrosis factor (TNF) secretion, can be extremely important. The use of the lowest possible GC dose, at night, and for the shortest possible time should therefore greatly reduce the risk of infections. Infection is a major co-morbidity in rheumatoid arthritis (RA), and conventional disease-modifying anti-rheumatic drugs (DMARDs) can increase the risk of their occurrence, including tuberculosis. TNF-alpha plays a key role in the pathogenesis of RA, and the data concerning infections in RA patients treated with anti-TNF agents are controversial. Patients and physicians should vigilantly monitor for signs of infection when using anti-TNF agents. Recombinant gene technologies now make it possible to produce protein drugs that are almost identical to naturally occurring human polypeptides, including antibody (Ab) constructs; unfortunately, all human biological agents are potentially immunogenic. An increasing number of recent studies have demonstrated the safety of influenza and pneumococcal vaccines administered to patients with systemic lupus erythematosus (SLE) or RA. These vaccinations are generally immunogenic (i.e., capable of inducing a protective level of specific antibodies) but may not induce an adequate response in a substantial proportion of patients. FAU - Atzeni, F AU - Atzeni F AD - Rheumatology Unit, L. Sacco Hospital, Milan, Italy. FAU - Bendtzen, K AU - Bendtzen K FAU - Bobbio-Pallavicini, F AU - Bobbio-Pallavicini F FAU - Conti, F AU - Conti F FAU - Cutolo, M AU - Cutolo M FAU - Montecucco, C AU - Montecucco C FAU - Sulli, A AU - Sulli A FAU - Valesini, G AU - Valesini G FAU - Sarzi-Puttini, P AU - Sarzi-Puttini P LA - eng PT - Journal Article PT - Review PL - Italy TA - Clin Exp Rheumatol JT - Clinical and experimental rheumatology JID - 8308521 RN - 0 (Antirheumatic Agents) SB - IM MH - Antirheumatic Agents/*adverse effects MH - Humans MH - *Immunocompromised Host MH - Infections/etiology/*immunology MH - Rheumatic Diseases/*drug therapy/*immunology RF - 51 EDAT- 2008/07/01 09:00 MHDA- 2008/08/12 09:00 CRDT- 2008/07/01 09:00 PHST- 2008/07/01 09:00 [pubmed] PHST- 2008/08/12 09:00 [medline] PHST- 2008/07/01 09:00 [entrez] AID - 2287 [pii] PST - ppublish SO - Clin Exp Rheumatol. 2008 Jan-Feb;26(1 Suppl 48):S67-73. PMID- 17553734 OWN - NLM STAT- MEDLINE DCOM- 20070904 LR - 20070626 IS - 1369-5274 (Print) IS - 1369-5274 (Linking) VI - 10 IP - 3 DP - 2007 Jun TI - From the deep sea to the stars: human life support through minimal communities. PG - 231-7 AB - Support of human life during long-distance exploratory space travel or in the creation of human habitats in extreme environments can be accomplished using the action of microbial consortia inhabiting interconnected bioreactors, designed for the purpose of reconversion of solid, liquid and gaseous wastes produced by the human crew or by one of the compartments of the bioregenerative loop, into nutritional biomass, oxygen and potable water. The microorganisms responsible for bioregenerative life support are part of Earth's own geomicrobial reconversion cycle. Depending on the resources and conditions available, minimal life support systems can be assembled using appropriately selected microorganisms that possess metabolic routes for each specific purpose in the transformation cycle. Under control of an engineered system, a reliable life-support system can hence be provided for. FAU - Hendrickx, Larissa AU - Hendrickx L AD - Molecular and Cellular Biology, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre SCK.CEN, Boeretang 200, Mol, Belgium. FAU - Mergeay, Max AU - Mergeay M LA - eng PT - Journal Article PT - Review DEP - 20070605 PL - England TA - Curr Opin Microbiol JT - Current opinion in microbiology JID - 9815056 SB - IM MH - Biomass MH - Bioreactors/*microbiology MH - *Ecological Systems, Closed MH - Environmental Microbiology MH - Humans MH - *Life Support Systems RF - 59 EDAT- 2007/06/08 09:00 MHDA- 2007/09/05 09:00 CRDT- 2007/06/08 09:00 PHST- 2007/02/12 00:00 [received] PHST- 2007/05/21 00:00 [accepted] PHST- 2007/06/08 09:00 [pubmed] PHST- 2007/09/05 09:00 [medline] PHST- 2007/06/08 09:00 [entrez] AID - S1369-5274(07)00054-9 [pii] AID - 10.1016/j.mib.2007.05.007 [doi] PST - ppublish SO - Curr Opin Microbiol. 2007 Jun;10(3):231-7. doi: 10.1016/j.mib.2007.05.007. Epub 2007 Jun 5. PMID- 29138934 OWN - NLM STAT- MEDLINE DCOM- 20171214 LR - 20181113 IS - 1432-1904 (Electronic) IS - 0028-1042 (Linking) VI - 104 IP - 11-12 DP - 2017 Nov 14 TI - Habitat quality affects stress responses and survival in a bird wintering under extremely low ambient temperatures. PG - 99 LID - 10.1007/s00114-017-1519-8 [doi] AB - Animals normally respond to stressful environmental stimuli by releasing glucocorticoid hormones. We investigated whether baseline corticosterone (CORT), handling-induced corticosterone concentration(s), and body condition indices of members of willow tit (Poecile montanus) groups differed while wintering in old growth forests and managed young forests in mild weather conditions and during cold spells. Willow tits spend the winter season in non-kin groups in which dominant individuals typically claim their priority to access resources, while subordinate individuals may experience greater levels of stress and higher mortality, especially during cold spells. We captured birds to measure baseline CORT and levels of handling-induced CORT secretion after 20 min of capture. Willow tits in the young forests had higher baseline CORT and a smaller increase in CORT in response to capture than individuals in the old forests. Baseline CORT was higher in females and juvenile birds compared to adult males, whereas handling-induced CORT secretion did not differ between birds of different ages. During cold spells, baseline CORT of willow tits increased and handling-induced CORT secretion decreased, especially in birds in young forests. Willow tits' survival was higher in the old forests, with dominant individuals surviving better than subordinates. Our results show that changes in CORT secretion reflect responses to habitat quality and climate harshness, indicating young managed coniferous forests as a suboptimal habitat for the willow tit. FAU - Cīrule, Dina AU - Cīrule D AD - Animal Health and Environment BIOR, Institute of Food Safety, Rīga, Latvia. FAU - Krama, Tatjana AU - Krama T AD - Department of Plant Protection, Institute of Agricultural and Environmental Sciences, Estonian University of Life Science, Tartu, Estonia. AD - Department of Biotechnology, Daugavpils University, Daugavpils, Latvia. FAU - Krams, Ronalds AU - Krams R AD - Department of Biotechnology, Daugavpils University, Daugavpils, Latvia. FAU - Elferts, Didzis AU - Elferts D AD - Department of Botany and Ecology, Faculty of Biology, University of Latvia, Rīga, Latvia. AD - Latvian State Forest Research Institute "Silava", Salaspils, Latvia. FAU - Kaasik, Ants AU - Kaasik A AD - Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia. FAU - Rantala, Markus J AU - Rantala MJ AD - Department of Biology, Turku Brain and Mind Centre, University of Turku, Turku, Finland. FAU - Mierauskas, Pranas AU - Mierauskas P AD - Department of Environment Policy, Mykolas Romeris University, Vilnius, Lithuania. FAU - Luoto, Severi AU - Luoto S AD - English, Drama and Writing Studies, and School of Psychology, University of Auckland, Auckland, 1010, New Zealand. FAU - Krams, Indrikis A AU - Krams IA AUID- ORCID: 0000-0001-7150-4108 AD - Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia. indrikis.krams@ut.ee. AD - Department of Zoology and Animal Ecology, Faculty of Biology, University of Latvia, Rīga, Latvia. indrikis.krams@ut.ee. LA - eng GR - PUT1223/Eesti Teadusagentuur/ GR - 290/2012/Latvijas Zinātnes Padome/ GR - 07.2100/Latvijas Zinātnes Padome/ PT - Journal Article DEP - 20171114 PL - Germany TA - Naturwissenschaften JT - Die Naturwissenschaften JID - 0400767 RN - W980KJ009P (Corticosterone) SB - IM MH - Animals MH - *Cold Temperature MH - Corticosterone/blood MH - *Ecosystem MH - Female MH - Male MH - Seasons MH - Stress, Physiological/*physiology MH - Survival Analysis OTO - NOTNLM OT - Corticosterone OT - Dominance hierarchy OT - Habitat quality OT - Stress OT - Willow tits OT - Winter survival EDAT- 2017/11/16 06:00 MHDA- 2017/12/15 06:00 CRDT- 2017/11/16 06:00 PHST- 2017/07/20 00:00 [received] PHST- 2017/10/17 00:00 [accepted] PHST- 2017/10/15 00:00 [revised] PHST- 2017/11/16 06:00 [entrez] PHST- 2017/11/16 06:00 [pubmed] PHST- 2017/12/15 06:00 [medline] AID - 10.1007/s00114-017-1519-8 [pii] AID - 10.1007/s00114-017-1519-8 [doi] PST - epublish SO - Naturwissenschaften. 2017 Nov 14;104(11-12):99. doi: 10.1007/s00114-017-1519-8. PMID- 11015144 OWN - NLM STAT- MEDLINE DCOM- 20001130 LR - 20241210 IS - 0895-8378 (Print) IS - 0895-8378 (Linking) VI - 12 IP - 11 DP - 2000 Nov TI - Safety assessment of continuous glass filaments used in eclipse. PG - 1071-84 AB - Eclipse is a cigarette that produces smoke by primarily heating, rather than burning, tobacco. The Eclipse heat source assembly employs a continuous filament glass mat jacket to insulate the heat source. The glass mat insulator is composed of continuous glass filaments and a binder. The purpose of this article is to address the potential toxicological significance of the continuous glass filaments under the conditions of intended use. Transfer data and the unique physical characteristics of the filaments demonstrate that significant exposure of the smoker will not occur. The available environmental survey data clearly demonstrate that Eclipse smokers are extremely unlikely to be exposed to continuous glass filaments at a level that represents a biologically significant increase over background exposure to glass fibers. The chemical composition of the continuous glass filaments used in Eclipse is generally similar to C-glass fiber compositions such as MMVF 11 that have failed to produce either tumors or fibrosis in chronic inhalation studies conducted in rats. In vitro dissolution data demonstrate that the continuous glass filaments used in Eclipse are more soluble than biologically active fibers such as rock wool (MMVF 21) or asbestos. However, the continuous glass filaments used in Eclipse were not as soluble in simulated extracellular lung fluid as representative C-glass fibers (MMVF 10 and MMVF 11). In brief, exposure of Eclipse smokers to continuous glass filaments is extremely unlikely to occur at a level that may be construed to be of biological significance. FAU - Swauger, J E AU - Swauger JE AD - Scientific and Regulatory Affairs, R. J. Reynolds Tobacco Company, PO Box 1487, Winston-Salem, NC 27102-1487, USA. swaugej@rjrt.com FAU - Foy, J W AU - Foy JW LA - eng PT - Journal Article PL - England TA - Inhal Toxicol JT - Inhalation toxicology JID - 8910739 RN - 0 (Smoke) SB - IM MH - Animals MH - Humans MH - Rats MH - Smoke/*adverse effects MH - *Smoking EDAT- 2000/10/03 11:00 MHDA- 2001/02/28 10:01 CRDT- 2000/10/03 11:00 PHST- 2000/10/03 11:00 [pubmed] PHST- 2001/02/28 10:01 [medline] PHST- 2000/10/03 11:00 [entrez] AID - 10.1080/08958370050164662 [doi] PST - ppublish SO - Inhal Toxicol. 2000 Nov;12(11):1071-84. doi: 10.1080/08958370050164662. PMID- 2063521 OWN - NLM STAT- MEDLINE DCOM- 19910802 LR - 20170214 IS - 0300-9858 (Print) IS - 0300-9858 (Linking) VI - 28 IP - 2 DP - 1991 Mar TI - Accumulation of 2,8 dihydroxyadenine in bovine liver, kidneys, and lymph nodes. PG - 99-109 AB - A variety of tissues from 20 cattle slaughtered at federally inspected facilities contained abundant light green to greenish-yellow material. Gross lesions were most common in the liver and hepatic lymph nodes. Less frequent lesions were present in the mediastinal, renal, intercostal, and gastric lymph nodes. The material was most prominent in the portal triads, and in the medullary sinuses of the lymph nodes, at times occupying up to one half of the nodal mass. Renal calculi were present in one animal. Histologically, the condition was characterized by the intracytoplasmic accumulation of innumerable brown, acicular crystals in hepatocytes, macrophages, and renal tubular epithelial cells. Less frequent large aggregates of extracellular crystals were found in the lumens of renal tubules and in portal triads. Crystals were highly birefringent when examined using polarized light. The crystals were identified as 2,8 dihydroxyadenine using X-ray diffraction, electron diffraction, infrared spectroscopy, and mass spectrometry. In mammals, adenine is normally converted to adenylate by the enzyme adenine phosphoribosyltransferase. When adenine phosphoribosyltransferase is absent, deficient, or inhibited, adenine is oxidized to 2,8 dihydroxyadenine, which is extremely insoluble at physiological pH. In human beings, an autosomal recessive disease known as 2,8 dihydroxyadeninuria is caused by a deficiency of adenine phosphoribosyltransferase. FAU - McCaskey, P C AU - McCaskey PC AD - United States Department of Agriculture, Food Safety and Inspection Service, Beltsville, MD. FAU - Rigsby, W E AU - Rigsby WE FAU - Hinton, D M AU - Hinton DM FAU - Friedlander, L AU - Friedlander L FAU - Hurst, V J AU - Hurst VJ LA - eng PT - Journal Article PL - United States TA - Vet Pathol JT - Veterinary pathology JID - 0312020 RN - 30377-37-8 (2,8-dihydroxyadenine) RN - JAC85A2161 (Adenine) SB - IM MH - Abattoirs MH - Adenine/*analogs & derivatives/analysis/metabolism MH - Animals MH - Cattle/*metabolism MH - Crystallization MH - Electron Probe Microanalysis MH - Kidney/chemistry/*metabolism/ultrastructure MH - Liver/chemistry/*metabolism/ultrastructure MH - Lymph Nodes/chemistry/*metabolism/ultrastructure MH - Mass Spectrometry MH - Microscopy, Electron MH - Microscopy, Electron, Scanning MH - Microscopy, Polarization MH - Spectrophotometry, Infrared MH - X-Ray Diffraction EDAT- 1991/03/01 00:00 MHDA- 1991/03/01 00:01 CRDT- 1991/03/01 00:00 PHST- 1991/03/01 00:00 [pubmed] PHST- 1991/03/01 00:01 [medline] PHST- 1991/03/01 00:00 [entrez] AID - 10.1177/030098589102800201 [doi] PST - ppublish SO - Vet Pathol. 1991 Mar;28(2):99-109. doi: 10.1177/030098589102800201. PMID- 19403053 OWN - NLM STAT- MEDLINE DCOM- 20090723 LR - 20090430 IS - 0393-5264 (Print) IS - 0393-5264 (Linking) VI - 24 IP - 1 DP - 2009 Jan-Mar TI - Anti-osteoporotic treatments in neurological diseases. PG - 41-4 AB - The constant ageing of the population has resulted in an increase in chronic conditions such as osteoporosis and neurodegenerative diseases as well as in patient comorbidity. Prolonged immobility, the use of osteopoenia-inducing drugs and an increased risk of falls in patients with neurological diseases have led to an increase in the incidence of fragility fractures, especially of the femur, in these patients. The consequences of these events are often dramatic, being associated with increased mortality, disability and worsening of cognitive and relational functions. Potent drugs are currently available that can reduce fracture risk by up to 50% with long-term safety and tolerability. Bisphosphonates are the agents most extensively used to prevent fragility fractures. Risedronate has been demonstrated to reduce fracture risk, also in patients with neurological conditions. Considering that osteoporosis requires chronic treatment, patient compliance is extremely important to obtain treatment efficacy. FAU - Giannini, Sandro AU - Giannini S AD - Department of Internal Medicine, University of Padua, Italy. sandro.giannini@pop.unipd.it LA - eng PT - Journal Article PT - Review PL - Italy TA - Funct Neurol JT - Functional neurology JID - 8707746 RN - 0 (Bone Density Conservation Agents) RN - 0 (Diphosphonates) SB - IM MH - Bone Density Conservation Agents/*therapeutic use MH - Diphosphonates/*therapeutic use MH - Humans MH - Nervous System Diseases/*complications/*drug therapy MH - Osteoporosis/*etiology/*prevention & control RF - 37 EDAT- 2009/05/01 09:00 MHDA- 2009/07/25 09:00 CRDT- 2009/05/01 09:00 PHST- 2009/05/01 09:00 [entrez] PHST- 2009/05/01 09:00 [pubmed] PHST- 2009/07/25 09:00 [medline] AID - 3375 [pii] PST - ppublish SO - Funct Neurol. 2009 Jan-Mar;24(1):41-4. PMID- 26376484 OWN - NLM STAT- MEDLINE DCOM- 20160602 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 9 DP - 2015 TI - Control of Precision Grip Force in Lifting and Holding of Low-Mass Objects. PG - e0138506 LID - 10.1371/journal.pone.0138506 [doi] LID - e0138506 AB - Few studies have investigated the control of grip force when manipulating an object with an extremely small mass using a precision grip, although some related information has been provided by studies conducted in an unusual microgravity environment. Grip-load force coordination was examined while healthy adults (N = 17) held a moveable instrumented apparatus with its mass changed between 6 g and 200 g in 14 steps, with its grip surface set as either sandpaper or rayon. Additional measurements of grip-force-dependent finger-surface contact area and finger skin indentation, as well as a test of weight discrimination, were also performed. For each surface condition, the static grip force was modulated in parallel with load force while holding the object of a mass above 30 g. For objects with mass smaller than 30 g, on the other hand, the parallel relationship was changed, resulting in a progressive increase in grip-to-load force (GF/LF) ratio. The rayon had a higher GF/LF force ratio across all mass levels. The proportion of safety margin in the static grip force and normalized moment-to-moment variability of the static grip force were also elevated towards the lower end of the object mass for both surfaces. These findings indicate that the strategy of grip force control for holding objects with an extremely small mass differs from that with a mass above 30 g. The data for the contact area, skin indentation, and weight discrimination suggest that a decreased level of cutaneous feedback signals from the finger pads could have played some role in a cost function in efficient grip force control with low-mass objects. The elevated grip force variability associated with signal-dependent and internal noises, and anticipated inertial force on the held object due to acceleration of the arm and hand, could also have contributed to the cost function. FAU - Hiramatsu, Yuichi AU - Hiramatsu Y AD - Department of Biomechanics and Motor Control, Graduate School of Medicine, Osaka University, Osaka, Japan. FAU - Kimura, Daisuke AU - Kimura D AD - Department of Biomechanics and Motor Control, Graduate School of Medicine, Osaka University, Osaka, Japan. FAU - Kadota, Koji AU - Kadota K AD - Department of Biomechanics and Motor Control, Graduate School of Medicine, Osaka University, Osaka, Japan. FAU - Ito, Taro AU - Ito T AD - Department of Health and Sports Sciences, Mukogawa Women's University, Hyogo, Japan. FAU - Kinoshita, Hiroshi AU - Kinoshita H AD - Department of Biomechanics and Motor Control, Graduate School of Medicine, Osaka University, Osaka, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150916 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Adult MH - Biomechanical Phenomena MH - Female MH - Fingers/*physiology MH - Hand Strength/*physiology MH - Humans MH - *Lifting MH - Male MH - Movement/*physiology MH - Psychomotor Performance MH - Weight-Bearing/*physiology MH - Young Adult PMC - PMC4574045 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2015/09/17 06:00 MHDA- 2016/06/03 06:00 PMCR- 2015/09/16 CRDT- 2015/09/17 06:00 PHST- 2014/12/25 00:00 [received] PHST- 2015/08/31 00:00 [accepted] PHST- 2015/09/17 06:00 [entrez] PHST- 2015/09/17 06:00 [pubmed] PHST- 2016/06/03 06:00 [medline] PHST- 2015/09/16 00:00 [pmc-release] AID - PONE-D-14-57842 [pii] AID - 10.1371/journal.pone.0138506 [doi] PST - epublish SO - PLoS One. 2015 Sep 16;10(9):e0138506. doi: 10.1371/journal.pone.0138506. eCollection 2015. PMID- 33040656 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201013 LR - 20211114 IS - 1471-2962 (Electronic) IS - 1364-503X (Print) IS - 1364-503X (Linking) VI - 378 IP - 2184 DP - 2020 Nov 13 TI - Inertial confinement fusion: a defence context. PG - 20200012 LID - 10.1098/rsta.2020.0012 [doi] LID - 20200012 AB - Almost 30 years since the last UK nuclear test, it remains necessary regularly to underwrite the safety and effectiveness of the National Nuclear Deterrent. To do so has been possible to date because of the development of continually improving science and engineering tools running on ever more powerful high-performance computing platforms, underpinned by cutting-edge experimental facilities. While some of these facilities, such as the Orion laser, are based in the UK, others are accessed by international collaboration. This is most notably with the USA via capabilities such as the National Ignition Facility, but also with France where a joint hydrodynamics facility is nearing completion following establishment of a Treaty in 2010. Despite the remarkable capability of the science and engineering tools, there is an increasing requirement for experiments as materials age and systems inevitably evolve further from what was specifically trialled at underground nuclear tests (UGTs). The data from UGTs will remain the best possible representation of the extreme conditions generated in a nuclear explosion, but it is essential to supplement these data by realizing new capabilities that will bring us closer to achieving laboratory simulations of these conditions. For high-energy-density physics, the most promising technique for generating temperatures and densities of interest is inertial confinement fusion (ICF). Continued research in ICF by the UK will support the certification of the deterrent for decades to come; hence the UK works closely with the international community to develop ICF science. UK Ministry of Defence © Crown Owned Copyright 2020/AWE. This article is part of a discussion meeting issue 'Prospects for high gain inertial fusion energy (part 1)'. FAU - Randewich, Andrew AU - Randewich A AD - Engineering and Science, AWE Plc, Aldermaston, Reading RG7 4PR, UK. FAU - Lock, Rob AU - Lock R AD - Engineering and Science, AWE Plc, Aldermaston, Reading RG7 4PR, UK. FAU - Garbett, Warren AU - Garbett W AD - Engineering and Science, AWE Plc, Aldermaston, Reading RG7 4PR, UK. FAU - Bethencourt-Smith, Dominic AU - Bethencourt-Smith D AD - Engineering and Science, AWE Plc, Aldermaston, Reading RG7 4PR, UK. LA - eng PT - Journal Article DEP - 20201012 PL - England TA - Philos Trans A Math Phys Eng Sci JT - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences JID - 101133385 SB - IM PMC - PMC7658755 OTO - NOTNLM OT - deterrence OT - high energy density physics OT - inertial confinement fusion COIS- The author(s) declare that they have no competing interests. EDAT- 2020/10/13 06:00 MHDA- 2020/10/13 06:01 PMCR- 2021/11/13 CRDT- 2020/10/12 05:19 PHST- 2020/10/12 05:19 [entrez] PHST- 2020/10/13 06:00 [pubmed] PHST- 2020/10/13 06:01 [medline] PHST- 2021/11/13 00:00 [pmc-release] AID - rsta20200012 [pii] AID - 10.1098/rsta.2020.0012 [doi] PST - ppublish SO - Philos Trans A Math Phys Eng Sci. 2020 Nov 13;378(2184):20200012. doi: 10.1098/rsta.2020.0012. Epub 2020 Oct 12. PMID- 9640557 OWN - NLM STAT- MEDLINE DCOM- 19980910 LR - 20130912 IS - 0011-4162 (Print) IS - 0011-4162 (Linking) VI - 61 IP - 6 DP - 1998 Jun TI - An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. PG - 347-50 AB - A number of genetic, intrinsic, and extrinsic factors can cause conditions of problem dry skin, marked by unusual dryness, rough texture, and extreme flaking and scaling, that are generally not controlled by conventional moisturizers. A study was undertaken to evaluate the safety and efficacy of two novel alpha hydroxy acid (AHA)-containing creams in reducing the appearance and symptoms of problem dry skin on subjects with a range of dry skin conditions, including xerosis, epidermolytic hyperkeratosis, and ichthyosis. Twenty subjects completed a course of treatment with either regular or extra strength AHA-blend cream on a test site, compared with a currently marketed, non-AHA moisturizing lotion on a control site. Subjects were treated for 4 weeks, with clinical evaluations performed at weeks 0, 2, and 4. The test for mulations reduced symptoms and improved cosmetic appearance following 2 weeks of use, with continued improvement following 4 weeks of use. Improvements were significant compared to baseline and compared to sites treated with the control lotion. Some patients experienced mild to moderate local adverse effects; all subjects were able to continue using the test product for the duration of the study. FAU - Kempers, S AU - Kempers S AD - Minnesota Clinical Study Center, Fridley 55432-3313, USA. FAU - Katz, H I AU - Katz HI FAU - Wildnauer, R AU - Wildnauer R FAU - Green, B AU - Green B LA - eng PT - Clinical Trial PT - Comparative Study PT - Controlled Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Cutis JT - Cutis JID - 0006440 RN - 0 (Cosmetics) RN - 0 (Hydroxy Acids) SB - IM MH - Adult MH - Aged MH - Analysis of Variance MH - Cosmetics/*administration & dosage MH - Female MH - Humans MH - Hydroxy Acids/*administration & dosage MH - Hyperkeratosis, Epidermolytic/*rehabilitation MH - Ichthyosis/*rehabilitation MH - Male MH - Middle Aged MH - Prognosis MH - Severity of Illness Index MH - Single-Blind Method MH - *Skin Care MH - Treatment Outcome EDAT- 1998/06/26 00:00 MHDA- 1998/06/26 00:01 CRDT- 1998/06/26 00:00 PHST- 1998/06/26 00:00 [pubmed] PHST- 1998/06/26 00:01 [medline] PHST- 1998/06/26 00:00 [entrez] PST - ppublish SO - Cutis. 1998 Jun;61(6):347-50. PMID- 39203308 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 17 IP - 16 DP - 2024 Aug 20 TI - Multi-Load Topology Optimization Design for the Structural Safety Maintenance of Low- and Intermediate-Level Radioactive Waste Packaging Containers in the Case of a Collision. LID - 10.3390/ma17164130 [doi] LID - 4130 AB - This paper presents an optimized design approach using nonlinear dynamic analysis and finite element methods to ensure the structural integrity of square-shaped containers made from ductile cast iron for intermediate- and low-level radioactive waste packaging. Ductile cast iron, with its spherical graphite structure, effectively distributes stress throughout the material, leading to a storage capacity increase of approximately 18%. Considering the critical need for containers that maintain integrity under extreme conditions like earthquakes, the design focuses on mitigating stress concentrations at the corners of square structures. Nonlinear dynamic analyses were conducted in five drop directions: three specified by ASTM-D5276 standards and two additional directions to account for different load patterns. Fractures were observed in four out of the five scenarios. For each direction where fractures occurred, equivalent loads causing similar displacement fields were applied to linear static models, which were then used for multi-load topology optimization. Three optimized models were derived, each increasing the volume by 1.4% to 1.6% compared to the original model, and the design that best met the structural integrity requirements during drop scenarios was selected. To further enhance the optimization process, weights were assigned to different load conditions based on numerical analysis results, balancing the impact of maximum stress, average stress, and plastic deformation energy. The final model, with its increased storage capacity and enhanced structural integrity, offers a practical solution for radioactive waste management, overcoming limitations in previous designs by effectively addressing complex load conditions. FAU - Lee, Jeong-In AU - Lee JI AD - Advanced Mobility Components Group, Korea Institute of Industrial Technology, Daegu 42994, Republic of Korea. AD - Department of Nanomechatronics Engineering, Pusan National University, Pusan 46241, Republic of Korea. FAU - Park, Sang-Wook AU - Park SW AD - Advanced Mobility Components Group, Korea Institute of Industrial Technology, Daegu 42994, Republic of Korea. AD - Department of Nanomechatronics Engineering, Pusan National University, Pusan 46241, Republic of Korea. FAU - Song, Hye-Jin AU - Song HJ AD - Advanced Mobility Components Group, Korea Institute of Industrial Technology, Daegu 42994, Republic of Korea. FAU - Cho, Yong-Jae AU - Cho YJ AD - Advanced Mobility Components Group, Korea Institute of Industrial Technology, Daegu 42994, Republic of Korea. FAU - Kim, Dong-Hwan AU - Kim DH AD - Department of Aviation Maintenance & Mechanical Engineering, Changshin University, Changwon-si 51352, Republic of Korea. FAU - Ko, Dae-Cheol AU - Ko DC AUID- ORCID: 0000-0002-4064-739X AD - Department of Nanomechatronics Engineering, Pusan National University, Pusan 46241, Republic of Korea. FAU - Jang, Jin-Seok AU - Jang JS AUID- ORCID: 0000-0002-6801-9109 AD - Advanced Mobility Components Group, Korea Institute of Industrial Technology, Daegu 42994, Republic of Korea. LA - eng GR - EH-24-0002/Korea Institute of Industrial Technology/ GR - 20015706/Korea Evaluation Institute of Industrial Technology/ PT - Journal Article DEP - 20240820 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC11356512 OTO - NOTNLM OT - collision OT - finite element method OT - low- and intermediate-level radioactive waste container OT - structural safety maintenance OT - topology optimization COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:50 MHDA- 2024/08/31 09:51 PMCR- 2024/08/20 CRDT- 2024/08/29 01:23 PHST- 2024/07/26 00:00 [received] PHST- 2024/08/17 00:00 [revised] PHST- 2024/08/18 00:00 [accepted] PHST- 2024/08/31 09:51 [medline] PHST- 2024/08/31 09:50 [pubmed] PHST- 2024/08/29 01:23 [entrez] PHST- 2024/08/20 00:00 [pmc-release] AID - ma17164130 [pii] AID - materials-17-04130 [pii] AID - 10.3390/ma17164130 [doi] PST - epublish SO - Materials (Basel). 2024 Aug 20;17(16):4130. doi: 10.3390/ma17164130. PMID- 32531374 OWN - NLM STAT- MEDLINE DCOM- 20201210 LR - 20201214 IS - 1879-2057 (Electronic) IS - 0001-4575 (Linking) VI - 144 DP - 2020 Sep TI - What happens when drivers of automated vehicles take over control in critical brake situations? PG - 105588 LID - S0001-4575(20)30104-4 [pii] LID - 10.1016/j.aap.2020.105588 [doi] AB - Even with automated vehicles, driving situations with short time headways and extreme vehicle dynamics may arise when unpredictable events occur. If drivers take back control under such conditions, it is uncertain how they behave and how well they can cope with the situation. This issue has not been investigated yet and is subject to our study. In a driving simulator, non-distracted participants (N = 42) experienced nine critical situations caused by a braking vehicle in front of them. Time headway and longitudinal vehicle dynamics were varied to create different degrees of objective criticality. Participants' criticality ratings, take-over behavior, and driving performance were recorded and analyzed. The results indicate that participants were sensitive to changes in objective criticality and adapted their behavior. Take-over times were very fast under all conditions and participants showed higher criticality ratings, more intense decelerations, and more lane changes with increasing objective criticality. To avoid a collision, participants decelerated much more than the automation and changed lanes, even though this was not necessary. Thereby, they raised the risk of vehicle instability, rear-end collisions, and collisions with overtaking vehicles. To conclude, take-overs in critical brake situations may be a threat to the safety of drivers and other road users because drivers' reactions are more pronounced than necessary. These results suggest that assistive functions are required to support drivers in critical take-over situations. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Roche, Fabienne AU - Roche F AD - Technische Universität Berlin, Germany. Electronic address: fabienne.roche@freenet.de. FAU - Thüring, Manfred AU - Thüring M AD - Technische Universität Berlin, Germany. FAU - Trukenbrod, Anna K AU - Trukenbrod AK AD - Technische Universität Berlin, Germany. LA - eng PT - Journal Article DEP - 20200610 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic/*prevention & control MH - Adult MH - *Automobile Driving MH - Computer Simulation MH - Female MH - Humans MH - Male MH - *Man-Machine Systems MH - Reaction Time MH - Risk Assessment MH - Young Adult OTO - NOTNLM OT - Critical driving situation OT - Driver behavior OT - Driving simulator OT - Human-automation interaction OT - Vehicle automation COIS- Declaration of Competing Interest None. EDAT- 2020/06/13 06:00 MHDA- 2020/12/15 06:00 CRDT- 2020/06/13 06:00 PHST- 2020/01/20 00:00 [received] PHST- 2020/04/08 00:00 [revised] PHST- 2020/05/07 00:00 [accepted] PHST- 2020/06/13 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2020/06/13 06:00 [entrez] AID - S0001-4575(20)30104-4 [pii] AID - 10.1016/j.aap.2020.105588 [doi] PST - ppublish SO - Accid Anal Prev. 2020 Sep;144:105588. doi: 10.1016/j.aap.2020.105588. Epub 2020 Jun 10. PMID- 16601486 OWN - NLM STAT- MEDLINE DCOM- 20061205 LR - 20131121 IS - 1040-8703 (Print) IS - 1040-8703 (Linking) VI - 18 IP - 2 DP - 2006 Apr TI - Strategies for prevention of nosocomial sepsis in the neonatal intensive care unit. PG - 101-6 AB - PURPOSE OF REVIEW: Infants hospitalized in the neonatal intensive care unit, particularly preterm infants, have very high rates of nosocomial sepsis (also referred to as late onset sepsis or healthcare-associated sepsis). Today's preventive strategies for nosocomial sepsis focus on augmenting the immunologic and functional immaturities of premature infants and ameliorating the risks of extrinsic factors by the use of prophylactic antibiotics and best clinical practices. RECENT FINDINGS: Topical emollients improved neonatal skin condition, but were associated with an increased risk of nosocomial bacterial sepsis and coagulase negative staphylococcal infections, and thus should not be used in extremely-low-birth-weight infants. Single-center studies have shown that probiotics containing anaerobic bacteria may reduce the rate of necrotizing enterocolitis, the severity of necrotizing enterocolitis, and/or bacterial sepsis. Single-center studies have shown that prophylactic fluconazole reduces the rates of invasive candidiasis and/or colonization of extremely-low-birth-weight infants. Quality improvement projects to improve adherence to appropriate hand hygiene and best practices for central venous catheter insertion and maintenance can reduce rates of nosocomial sepsis. SUMMARY: The safety and efficacy of probiotics and prophylactic fluconazole require large multicenter trials. Quality improvement initiatives, however, can be performed now and can reduce the rates of nosocomial sepsis in the neonatal intensive care unit. FAU - Saiman, Lisa AU - Saiman L AD - Columbia University, Department of Pediatrics, Division of Infectious Diseases, New York 10032, USA. LS5@columbia.edu LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 RN - 0 (Antifungal Agents) RN - 0 (Emollients) RN - 8VZV102JFY (Fluconazole) SB - IM MH - Antifungal Agents/therapeutic use MH - Candidiasis/prevention & control MH - Catheterization, Central Venous/adverse effects MH - Cross Infection/*prevention & control MH - Emollients/therapeutic use MH - Fluconazole/therapeutic use MH - Gastrointestinal Tract/drug effects MH - Humans MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - Probiotics/pharmacology/therapeutic use MH - Sepsis/*prevention & control RF - 28 EDAT- 2006/04/08 09:00 MHDA- 2006/12/09 09:00 CRDT- 2006/04/08 09:00 PHST- 2006/04/08 09:00 [pubmed] PHST- 2006/12/09 09:00 [medline] PHST- 2006/04/08 09:00 [entrez] AID - 00008480-200604000-00003 [pii] AID - 10.1097/01.mop.0000193300.25141.c5 [doi] PST - ppublish SO - Curr Opin Pediatr. 2006 Apr;18(2):101-6. doi: 10.1097/01.mop.0000193300.25141.c5. PMID- 34212011 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210703 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 8 DP - 2021 TI - Physical Activity and Exercise Patterns After Spontaneous Coronary Artery Dissection: Insights From a Large Multinational Registry. PG - 642739 LID - 10.3389/fcvm.2021.642739 [doi] LID - 642739 AB - Objective: The objective of the study was to assess the physical activity (PA) and exercise patterns among participants in a large multinational spontaneous coronary artery dissection (SCAD) registry. Patients and Methods: Participants with SCAD enrolled from March 2011 to November 2019 completed surveys including details regarding PA and exercise habits prior to SCAD, and PA counseling received from their provider after SCAD. Demographics and clinical characteristics were collected by electronic record review. Exercise prescribed to patients after SCAD was categorized according to exercise components: type, intensity, frequency, time/session, and extreme environmental conditions. Results: We included 950 participants; mean ± age was 46.8 ± 9.5 years old at the time of first SCAD; most (96.3%) were women and (77.0%) attended ≥1 cardiac rehabilitation session. Hyperlipidemia (34.3%), hypertension (32.8%), and elevated body weight (overweight = 27.0%; obesity = 20.0%) were the most common comorbidities. Prior to SCAD, 48.5% performed aerobic exercise ≥3 times/week, and only 32.0% performed strength-building exercise regularly. PA counseling details after SCAD in 299/950 participants showed that most (93.3%) patients received some form of counseling including exercise prescription (EXP), non-specific recommendations, and discouraged from any exercise. Limits regarding exercise type and intensity were the most common advice among participants who received EXP. Conclusion: Insights from our study suggest that only 48% of the patients performed some aerobic exercise three or more times per week, and 32.0% performed strength-building exercises, which suggest that most of them may not be as active as assumed. Furthermore, 70% of the SCAD patients have ≥1 cardiovascular risk factors. We suggest guiding patients based on individual assessment, taking into consideration baseline PA habits, treatment, and risk factors. SCAD-tailored PA guidelines are needed for optimal EXP without compromising patient safety. CI - Copyright © 2021 Chacin-Suarez, Bonikowske, Medina-Inojosa, Gulati, Best, Hayes and Tweet. FAU - Chacin-Suarez, Audry S AU - Chacin-Suarez AS AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Bonikowske, Amanda R AU - Bonikowske AR AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Medina-Inojosa, Jose R AU - Medina-Inojosa JR AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Gulati, Rajiv AU - Gulati R AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Best, Patricia J AU - Best PJ AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Hayes, Sharonne N AU - Hayes SN AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. FAU - Tweet, Marysia S AU - Tweet MS AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States. LA - eng PT - Journal Article DEP - 20210615 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC8240509 OTO - NOTNLM OT - exercise OT - exercise prescription OT - physical exertion OT - spontaneous coronary artery dissection OT - women cardiovascular disease OT - young adult COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/07/03 06:00 MHDA- 2021/07/03 06:01 PMCR- 2021/01/01 CRDT- 2021/07/02 06:43 PHST- 2020/12/17 00:00 [received] PHST- 2021/04/20 00:00 [accepted] PHST- 2021/07/02 06:43 [entrez] PHST- 2021/07/03 06:00 [pubmed] PHST- 2021/07/03 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fcvm.2021.642739 [doi] PST - epublish SO - Front Cardiovasc Med. 2021 Jun 15;8:642739. doi: 10.3389/fcvm.2021.642739. eCollection 2021. PMID- 39809080 OWN - NLM STAT- MEDLINE DCOM- 20250124 LR - 20250124 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 195 DP - 2025 Jan TI - The association between short-term apparent temperature exposure and human coagulation: A time-series study from Beijing, 2014-2023. PG - 109262 LID - S0160-4120(25)00013-3 [pii] LID - 10.1016/j.envint.2025.109262 [doi] AB - A growing body of evidence suggests that non-optimal ambient temperatures are associated with increased incidence rate and mortality of thromboembolic diseases. We aim to investigate the association between apparent temperature (AT) and coagulation, which is a central pathological link in the formation of thrombi. In this study, we conducted a time series analysis using data from 18,894 participants collected from a health check-up center in Beijing between 2014 and 2023, and validated our findings using 20,549 participants from an andrology outpatient clinic. The daily mean AT was calculated using data on ambient temperature, relative humidity, and wind speed from Beijing. Participants were matched to the lagged moving average of AT (0-7 days) based on their specific health examination dates. The study employed generalized additive models to analyzed the linear and nonlinear associations between AT and coagulation indices. The results indicated that heat resulted in shortened prothrombin time and activated partial thromboplastin time, whereas cold resulted in shortened thrombin time. Fibrinogen showed an increase at both high and low temperatures. Logistic regression analysis revealed that the risk of hypercoagulable state increased in both high and low temperature environments compared to moderate temperatures, with a significant increase observed under extreme heat conditions. Subgroup analyses by sex and age, sensitivity analyses, and the external validation indicated that the association between AT and coagulation was robust. The findings support that both cold and heat can augment blood coagulability through distinct stages of the coagulation cascade, thereby leading to an elevated risk of thromboembolic diseases. CI - Copyright © 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Zhang, Yi AU - Zhang Y AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Wang, Tiancheng AU - Wang T AD - Department of Laboratory Medicine, Peking University Third Hospital, Beijing, 100191, China. FAU - Shi, Jiaqi AU - Shi J AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Ma, Ying AU - Ma Y AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Yu, Nairui AU - Yu N AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Zhou, Xinyan AU - Zhou X AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Zheng, Pai AU - Zheng P AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. FAU - Chen, Zhangjian AU - Chen Z AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. Electronic address: zhangjianchen@pku.edu.cn. FAU - Jia, Guang AU - Jia G AD - Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China. LA - eng PT - Journal Article DEP - 20250110 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 SB - IM MH - Humans MH - Beijing MH - *Blood Coagulation/physiology MH - Female MH - Male MH - Middle Aged MH - *Temperature MH - Adult MH - Aged MH - Hot Temperature MH - Prothrombin Time OTO - NOTNLM OT - Ambient temperature OT - Cardiovascular disease OT - Coagulation OT - Fibrinogen OT - Prothrombin time COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/15 00:20 MHDA- 2025/01/25 13:54 CRDT- 2025/01/14 18:09 PHST- 2024/09/02 00:00 [received] PHST- 2024/12/30 00:00 [revised] PHST- 2025/01/07 00:00 [accepted] PHST- 2025/01/25 13:54 [medline] PHST- 2025/01/15 00:20 [pubmed] PHST- 2025/01/14 18:09 [entrez] AID - S0160-4120(25)00013-3 [pii] AID - 10.1016/j.envint.2025.109262 [doi] PST - ppublish SO - Environ Int. 2025 Jan;195:109262. doi: 10.1016/j.envint.2025.109262. Epub 2025 Jan 10. PMID- 26164224 OWN - NLM STAT- MEDLINE DCOM- 20161028 LR - 20161230 IS - 1542-7714 (Electronic) IS - 1542-3565 (Linking) VI - 14 IP - 1 DP - 2016 Jan TI - Risks and Benefits of Colonoscopy in Patients 90 Years or Older, Compared With Younger Patients. PG - 80-6.e1 LID - S1542-3565(15)00912-X [pii] LID - 10.1016/j.cgh.2015.06.036 [doi] AB - BACKGROUND & AIMS: Although the numbers of medical procedures performed on extremely elderly patients (90 years or older, nonagenarians) are increasing, there are no data on the performance, diagnostic yield, or safety of colonoscopy for these patients. We compared the performance and safety of diagnostic colonoscopy, as well as lesions detected, in nonagenarians with patients who were 75 to 79 years old. METHODS: In a retrospective study, we compared data from 76 extremely elderly patients (90 years or older) with data from 140 very elderly patients (75 to 79 years old, controls), all of whom underwent diagnostic colonoscopy from January 2010 through March 2013 at Virginia Mason Medical Center. All colonoscopies were performed by 15 endoscopists. We compared rates of colonoscopy completion, bowel preparation quality, diagnostic yield, and adverse events. RESULTS: In extremely elderly patients, more colonoscopies were performed under general anesthesia, compared with controls (P < .001). When extremely elderly patients underwent colonoscopies with moderate sedation, lower doses of midazolam and fentanyl were given, compared with controls (P < .001). Colonoscopies were completed in a lower proportion of extremely elderly patients (88.2% vs. 99.3% for controls, P < .001), and these patients had a higher incidence of inadequate bowel preparation (29.7% vs. 15.0% for controls, P = .011). Colonoscopies were also associated with cardiopulmonary events in a higher proportion of extremely elderly patients (P = .006) as well as overall adverse events, compared with controls (P = .002). A higher proportion of extremely elderly patients were found to have advanced neoplasia (28.4% vs. 6.4% of controls, P < .001) as well as any neoplasia (P < .001 vs. controls). A greater percentage of extremely elderly patients also had large lesions (P = .002) and malignancies detected by histology (P < .001 vs. controls). Eleven extremely elderly patients (14.9%) were found to have cancer or high-grade dysplasia by colonoscopy. CONCLUSIONS: In patients 90 years or older, diagnostic colonoscopy is associated with increased risk for incomplete procedure, inadequate bowel preparation, and adverse events. However, a large proportion of patients are found to have advanced neoplasia and cancer, compared with patients 75 to 79 years old. CI - Copyright © 2016. Published by Elsevier Inc. FAU - Cha, Jae Myung AU - Cha JM AD - Gastroenterology Division, Kyung Hee University Hospital at Gang Dong, Kyung Hee University School of Medicine, Seoul, South Korea; Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Kozarek, Richard A AU - Kozarek RA AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - La Selva, Danielle AU - La Selva D AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Gluck, Michael AU - Gluck M AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Ross, Andrew AU - Ross A AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Chiorean, Michael AU - Chiorean M AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Koch, Johannes AU - Koch J AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. FAU - Lin, Otto S AU - Lin OS AD - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington. Electronic address: ottoslin@yahoo.com. LA - eng PT - Journal Article DEP - 20150709 PL - United States TA - Clin Gastroenterol Hepatol JT - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JID - 101160775 SB - IM MH - Aged MH - Aged, 80 and over MH - Colonic Neoplasms/*diagnosis MH - Colonoscopy/*adverse effects/*methods MH - Female MH - Humans MH - Male MH - Retrospective Studies MH - Risk Assessment MH - Virginia OTO - NOTNLM OT - Colon Cancer Detection OT - Complication OT - Old Age OT - Risk Factor EDAT- 2015/07/15 06:00 MHDA- 2016/11/01 06:00 CRDT- 2015/07/13 06:00 PHST- 2014/12/07 00:00 [received] PHST- 2015/06/26 00:00 [revised] PHST- 2015/06/26 00:00 [accepted] PHST- 2015/07/13 06:00 [entrez] PHST- 2015/07/15 06:00 [pubmed] PHST- 2016/11/01 06:00 [medline] AID - S1542-3565(15)00912-X [pii] AID - 10.1016/j.cgh.2015.06.036 [doi] PST - ppublish SO - Clin Gastroenterol Hepatol. 2016 Jan;14(1):80-6.e1. doi: 10.1016/j.cgh.2015.06.036. Epub 2015 Jul 9. PMID- 14518158 OWN - NLM STAT- MEDLINE DCOM- 20031023 LR - 20061115 IS - 0017-7768 (Print) IS - 0017-7768 (Linking) VI - 142 IP - 8-9 DP - 2003 Sep TI - [ECMO--extra corporeal membrane oxygenation as a bridge to recovery, following surgery for complex congenital cardiac anomalies, in children and neonates]. PG - 583-7, 648, 647 AB - BACKGROUND: ECMO is used as a method for mechanical life support in the face of extreme cardiopulmonary failure. Most children and neonates that require ECMO do so because of respiratory failure unresponsive to conventional supportive measures. Less then 16% of the patients require ECMO support for the failing heart. The Sheba Medical Center, is one of two centers in Israel authorized by the Ministry of Health to use ECMO technique and is the only center that also performs pediatric cardiac surgery. OBJECTIVES: To present our experience with ECMO support in patients with low cardiac output syndromes following open-heart surgery for congenital cardiac anomalies as compared to international experience. METHODS: The charts of all pediatric and neonatal patients requiring ECMO support following cardiac surgery for complex congenital cardiac anomalies were reviewed. Patient and ECMO characteristics were compared, as well as the success rates. RESULTS: Between 1995 and 2001, sixteen neonates and children were treated at our institution by ECMO for low cardiac output syndromes following heart surgery. Twelve were operated on at our institution, and four were referred to the ECMO unit of our pediatric critical care ward from other hospitals. ECMO support resulted in full recovery in seven of the sixteen patients, cardiac function returned to normal and the patients were discharged home in good condition, nine patients died. CONCLUSIONS: Our experience is in accord with the reported international experience. Following cardiac surgery for congenital cardiac anomalies, low cardiac output, unresponsive to maximal conventional medical support, is a rare but life threatening condition. Extracorporeal membrane oxygenation serves as a rescue mechanical support for these patients and due to improved and sophisticated intensive care, can serve as a bridge to recovery. The availability of ECMO provides an extra margin of safety in the very complex cases of open-heart surgery. FAU - Vardi, Amir AU - Vardi A AD - Department of Pediatric Critical Care, Sheba Medical Center, Tel Hashomer, Israel. FAU - Abed, Machmood AU - Abed M FAU - Mishali, David AU - Mishali D FAU - Levin, Inbal AU - Levin I FAU - Paret, Gideon AU - Paret G FAU - Barzilay, Zohar AU - Barzilay Z LA - heb PT - English Abstract PT - Journal Article PL - Israel TA - Harefuah JT - Harefuah JID - 0034351 SB - IM MH - Cardiac Output, Low/therapy MH - Child MH - Child, Preschool MH - Extracorporeal Membrane Oxygenation/*methods MH - Heart Defects, Congenital/surgery/*therapy MH - Humans MH - Infant MH - Infant, Newborn MH - Postoperative Care EDAT- 2003/10/02 05:00 MHDA- 2003/10/24 05:00 CRDT- 2003/10/02 05:00 PHST- 2003/10/02 05:00 [pubmed] PHST- 2003/10/24 05:00 [medline] PHST- 2003/10/02 05:00 [entrez] PST - ppublish SO - Harefuah. 2003 Sep;142(8-9):583-7, 648, 647. PMID- 34140885 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210619 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 15 DP - 2021 TI - Frontal EEG-Based Multi-Level Attention States Recognition Using Dynamical Complexity and Extreme Gradient Boosting. PG - 673955 LID - 10.3389/fnhum.2021.673955 [doi] LID - 673955 AB - Measuring and identifying the specific level of sustained attention during continuous tasks is essential in many applications, especially for avoiding the terrible consequences caused by reduced attention of people with special tasks. To this end, we recorded EEG signals from 42 subjects during the performance of a sustained attention task and obtained resting state and three levels of attentional states using the calibrated response time. EEG-based dynamical complexity features and Extreme Gradient Boosting (XGBoost) classifier were proposed as the classification model, Complexity-XGBoost, to distinguish multi-level attention states with improved accuracy. The maximum average accuracy of Complexity-XGBoost were 81.39 ± 1.47% for four attention levels, 80.42 ± 0.84% for three attention levels, and 95.36 ± 2.31% for two attention levels in 5-fold cross-validation. The proposed method is compared with other models of traditional EEG features and different classification algorithms, the results confirmed the effectiveness of the proposed method. We also found that the frontal EEG dynamical complexity measures were related to the changing process of response during sustained attention task. The proposed dynamical complexity approach could be helpful to recognize attention status during important tasks to improve safety and efficiency, and be useful for further brain-computer interaction research in clinical research or daily practice, such as the cognitive assessment or neural feedback treatment of individuals with attention deficit hyperactivity disorders, Alzheimer's disease, and other diseases which affect the sustained attention function. CI - Copyright © 2021 Wan, Cui, Gao and Gu. FAU - Wan, Wang AU - Wan W AD - State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, China. FAU - Cui, Xingran AU - Cui X AD - Key Laboratory of Child Development and Learning Science, Ministry of Education, School of Biological Science & Medical Engineering, Southeast University, Nanjing, China. AD - Institute of Biomedical Devices (Suzhou), Southeast University, Suzhou, China. FAU - Gao, Zhilin AU - Gao Z AD - State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, China. FAU - Gu, Zhongze AU - Gu Z AD - State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing, China. AD - Institute of Biomedical Devices (Suzhou), Southeast University, Suzhou, China. LA - eng PT - Journal Article DEP - 20210601 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC8204057 OTO - NOTNLM OT - attention recognition OT - dynamical complexity OT - electroencephalogram OT - extreme gradient boosting OT - sustained attention task COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/06/19 06:00 MHDA- 2021/06/19 06:01 PMCR- 2021/01/01 CRDT- 2021/06/18 06:41 PHST- 2021/02/28 00:00 [received] PHST- 2021/04/26 00:00 [accepted] PHST- 2021/06/18 06:41 [entrez] PHST- 2021/06/19 06:00 [pubmed] PHST- 2021/06/19 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fnhum.2021.673955 [doi] PST - epublish SO - Front Hum Neurosci. 2021 Jun 1;15:673955. doi: 10.3389/fnhum.2021.673955. eCollection 2021. PMID- 9501350 OWN - NLM STAT- MEDLINE DCOM- 19980611 LR - 20061115 IS - 0253-1933 (Print) IS - 0253-1933 (Linking) VI - 16 IP - 2 DP - 1997 Aug TI - [Sanitary conditions for the production of beef cattle in Argentina]. PG - 369-81 AB - Meat production is extremely important for the economy of Argentina, and represents 35%-40% of all national agricultural production. Cattle are distributed throughout the country, with the highest density in the Pampa region, which hosts 66% of the national herd and produces 80% of the total meat production in Argentina. This region has a long tradition of livestock rearing, and the practice of rotation between agriculture and animal husbandry ensures an ecological equilibrium. Meat production in Argentina is based on the exploitation of natural resources, with traditional extensive grazing, which offers advantages when compared with other countries. The composition of meat depends on factors such as breed and age, and on the diet of the animals. The authors demonstrate that meat produced under extensive grazing conditions in Argentina has less intramuscular fat and cholesterol than that produced in intensive systems which have a grain-rich diet. The authors analyse the situation of the country with regard to diseases which can be transmitted by meat and which might affect public health, particularly bovine spongiform encephalopathy (BSE), brucellosis, tuberculosis, salmonellosis, campylobacteriosis, colibacillosis and taeniosis. The fact that Argentina is free from BSE is emphasised, and the prevention programmes which have been implemented to control other diseases are described. In addition, the authors discuss tests which are conducted to detect the presence of residues of chemical contaminants in meat. Emphasis is given to the quality of infrastructure, equipment and operation of the mechanised meat-processing plants, which guarantee the hygienic safety of the products. The authors conclude that meat and meat products from Argentina offer a high level of safety for consumers. FAU - Lasta, J A AU - Lasta JA AD - Instituto Tecnología de Alimentos, Instituto Nacional de Tecnología Agropecuaria, Morón, Buenos Aires, Argentina. FAU - Rearte, D AU - Rearte D LA - spa PT - English Abstract PT - Journal Article TT - Condiciones sanitarias de la producción de carne bovina en Argentina. PL - France TA - Rev Sci Tech JT - Revue scientifique et technique (International Office of Epizootics) JID - 8712301 SB - IM MH - Animal Husbandry/economics/*standards MH - Animals MH - Argentina/epidemiology MH - Cattle/*physiology MH - Cattle Diseases/*epidemiology/prevention & control MH - Food Contamination MH - Food Microbiology MH - Meat/economics/*standards MH - Meat Products/economics/standards MH - *Sanitation EDAT- 1997/08/01 00:00 MHDA- 1998/03/21 00:01 CRDT- 1997/08/01 00:00 PHST- 1997/08/01 00:00 [pubmed] PHST- 1998/03/21 00:01 [medline] PHST- 1997/08/01 00:00 [entrez] PST - ppublish SO - Rev Sci Tech. 1997 Aug;16(2):369-81. PMID- 31032967 OWN - NLM STAT- MEDLINE DCOM- 20190726 LR - 20190726 IS - 1097-0010 (Electronic) IS - 0022-5142 (Linking) VI - 99 IP - 11 DP - 2019 Aug 30 TI - Impact of climate change on aflatoxin M1 contamination of raw milk with special focus on climate conditions in Serbia. PG - 5202-5210 LID - 10.1002/jsfa.9768 [doi] AB - BACKGROUND: The impact of climate change has been identified as an emerging issue worldwide owing to potential effects that can provoke changes in the nature and occurrence of food safety hazards. Mycotoxins are a group of naturally occurring toxic substances produced by several genera of filamentous fungi, among which, primarily aflatoxins, fumonisins, ochratoxins, trichothecenes and zearalenone are of the greatest concern owing to their negative impact on human health, animal productivity and international trade. RESULTS: Extreme weather conditions such as floods and droughts which have not occurred previously in Serbia may be supporting factors for contamination of crops by various species of toxigenic fungi and their related mycotoxins. In this study, principal component analysis (PCA) and multivariate analyses were used as powerful tools allowing better understanding of the range of climate factors impacting on crop contamination by mycotoxins. Among the selected environmental variables, temperature and moisture significantly influenced aflatoxin production. Recent drought and then flooding confirmed that Serbia is one of the few European countries with very high risk exposure to natural hazards, as well as that mycotoxins are one of the foodborne hazards most susceptible to climate change. Thus climate change effects on mycotoxigenic fungi and mycotoxin contamination are now receiving scientific attention, especially from a risk analysis perspective. CONCLUSION: This paper evaluates the available information on the influence of climate change on mycotoxin contamination, especially aflatoxin M1 (AFM1). In addition, this investigation should beneficially contribute to more accurate predictions of the regional risk from mycotoxins in future decades. © 2019 Society of Chemical Industry. CI - © 2019 Society of Chemical Industry. FAU - Milićević, Dragan AU - Milićević D AUID- ORCID: 0000-0001-9001-0584 AD - Adviser of Director for Scientific Research, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Petronijević, Radivoj AU - Petronijević R AUID- ORCID: 0000-0002-3901-3824 AD - Department of Chemical and Physicochemical Analysis, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Petrović, Zoran AU - Petrović Z AD - Coordinator of the Institute's Management System, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Đjinović-Stojanović, Jasna AU - Đjinović-Stojanović J AD - Department for Residue Testing, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Jovanović, Jelena AU - Jovanović J AD - Department of Sensory and Physical Testing and Parasitology, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Baltić, Tatjana AU - Baltić T AD - Department of Microbiological and Molecular-Biological Research, Institute of Meat Hygiene and Technology, Belgrade, Serbia. FAU - Janković, Saša AU - Janković S AD - Department for Residue Testing, Institute of Meat Hygiene and Technology, Belgrade, Serbia. LA - eng PT - Journal Article DEP - 20190604 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 RN - 6795-23-9 (Aflatoxin M1) MH - Aflatoxin M1/*analysis/metabolism MH - Animal Feed/analysis MH - Animals MH - Aspergillus/metabolism MH - Cattle MH - Climate Change MH - Crops, Agricultural/chemistry/*microbiology MH - Ecosystem MH - Female MH - Food Contamination/analysis MH - Food Safety MH - Milk/*chemistry MH - Models, Biological MH - Principal Component Analysis MH - Serbia MH - Temperature OTO - NOTNLM OT - aflatoxins OT - climate change OT - food safety OT - mycotoxins EDAT- 2019/04/30 06:00 MHDA- 2019/07/28 06:00 CRDT- 2019/04/30 06:00 PHST- 2019/02/05 00:00 [received] PHST- 2019/04/08 00:00 [revised] PHST- 2019/04/23 00:00 [accepted] PHST- 2019/04/30 06:00 [pubmed] PHST- 2019/07/28 06:00 [medline] PHST- 2019/04/30 06:00 [entrez] AID - 10.1002/jsfa.9768 [doi] PST - ppublish SO - J Sci Food Agric. 2019 Aug 30;99(11):5202-5210. doi: 10.1002/jsfa.9768. Epub 2019 Jun 4. PMID- 31874049 OWN - NLM STAT- MEDLINE DCOM- 20220310 LR - 20220311 IS - 1547-8181 (Electronic) IS - 0018-7208 (Linking) VI - 63 IP - 3 DP - 2021 May TI - Designing for the Extremes: Modeling Drivers' Response Time to Take Back Control From Automation Using Bayesian Quantile Regression. PG - 519-530 LID - 10.1177/0018720819893429 [doi] AB - OBJECTIVE: Understanding the factors that affect drivers' response time in takeover from automation can help guide the design of vehicle systems to aid drivers. Higher quantiles of the response time distribution might indicate a higher risk of an unsuccessful takeover. Therefore, assessments of these systems should consider upper quantiles rather than focusing on the central tendency. BACKGROUND: Drivers' responses to takeover requests can be assessed using the time it takes the driver to take over control. However, all the takeover timing studies that we could find focused on the mean response time. METHOD: A study using an advanced driving simulator evaluated the effect of takeover request timing, event type at the onset of a takeover, and visual demand on drivers' response time. A mixed effects model was fit to the data using Bayesian quantile regression. RESULTS: Takeover request timing, event type that precipitated the takeover, and the visual demand all affect driver response time. These factors affected the 85th percentile differently than the median. This was most evident in the revealed stopped vehicle event and conditions with a longer time budget and scenes with lower visual demand. CONCLUSION: Because the factors affect the quantiles of the distribution differently, a focus on the mean response can misrepresent actual system performance. The 85th percentile is an important performance metric because it reveals factors that contribute to delayed responses and potentially dangerous outcomes, and it also indicates how well the system accommodates differences between drivers. FAU - DinparastDjadid, Azadeh AU - DinparastDjadid A AUID- ORCID: 0000-0002-4676-3551 AD - 5228 University of Wisconsin-Madison, USA. FAU - Lee, John D AU - Lee JD AD - 5228 University of Wisconsin-Madison, USA. FAU - Domeyer, Joshua AU - Domeyer J AD - 5228 University of Wisconsin-Madison, USA. AD - 116612 Toyota Collaborative Safety Research Center, Ann Arbor, USA. FAU - Schwarz, Chris AU - Schwarz C AD - 4083 University of Iowa, Coralville, USA. FAU - Brown, Timothy L AU - Brown TL AD - 4083 University of Iowa, Coralville, USA. FAU - Gunaratne, Pujitha AU - Gunaratne P AD - 116612 Toyota Collaborative Safety Research Center, Ann Arbor, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191224 PL - United States TA - Hum Factors JT - Human factors JID - 0374660 SB - IM MH - Automation MH - *Automobile Driving MH - Bayes Theorem MH - Humans MH - Reaction Time/physiology OTO - NOTNLM OT - Bayesian methods OT - automated vehicles OT - driver behavior OT - quantile regression OT - takeover time EDAT- 2019/12/25 06:00 MHDA- 2022/03/11 06:00 CRDT- 2019/12/25 06:00 PHST- 2019/12/25 06:00 [pubmed] PHST- 2022/03/11 06:00 [medline] PHST- 2019/12/25 06:00 [entrez] AID - 10.1177/0018720819893429 [doi] PST - ppublish SO - Hum Factors. 2021 May;63(3):519-530. doi: 10.1177/0018720819893429. Epub 2019 Dec 24. PMID- 8226703 OWN - NLM STAT- MEDLINE DCOM- 19931217 LR - 20191101 IS - 0733-2459 (Print) IS - 0733-2459 (Linking) VI - 8 IP - 2 DP - 1993 TI - Safety of the blood supply. PG - 110-6 AB - This is a review of events when the medical community realized that AIDS was an infectious disease which might be transmitted by blood transfusions and the response by the various organizations and agencies to curb the potential spread of HIV via blood products. It became possible through a number of approaches to make the blood supply safe so that today the likelihood of transmission of HIV by blood transfusion is extremely unlikely. FAU - Perkins, H A AU - Perkins HA AD - Irwin Memorial Blood Centers, San Francisco, CA 94118-4496. LA - eng PT - Journal Article PT - Review PL - United States TA - J Clin Apher JT - Journal of clinical apheresis JID - 8216305 SB - IM MH - Acquired Immunodeficiency Syndrome/*transmission MH - Blood Donors MH - Humans MH - Infant, Newborn MH - Risk Factors MH - Serologic Tests MH - Surveys and Questionnaires MH - *Transfusion Reaction RF - 25 EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1002/jca.2920080210 [doi] PST - ppublish SO - J Clin Apher. 1993;8(2):110-6. doi: 10.1002/jca.2920080210. PMID- 37337932 OWN - NLM STAT- MEDLINE DCOM- 20230915 LR - 20230918 IS - 1097-0290 (Electronic) IS - 0006-3592 (Linking) VI - 120 IP - 10 DP - 2023 Oct TI - Protection of biomanufacturing processes from virus contamination through upstream virus filtration of cell culture media. PG - 2917-2924 LID - 10.1002/bit.28473 [doi] AB - Cell-based manufacturing processes have occasionally been exposed to adventitious viruses, leading to manufacturing interruptions and unstable supply situations. The rapid progress of advanced therapy medicinal products needs innovative approaches to avoid any unwelcome reminder of the universal presence of viruses. Here, we investigated upstream virus filtration as a clearance step for any product too complex for downstream interventions. Culture media virus filtration was investigated with respect to virus clearance capacities under extreme conditions such as high process feed loading (up to ~19,000 L/m²), long duration (up to 34 days), and multiple process interruptions (up to 21 h). The small nonenveloped Minute virus of mice was used as relevant target virus, and as worse-case challenge for the investigated virus filters with a stipulated pore-size of about 20 nm. Certain filters-especially of the newer second generation-were capable of effective virus clearance despite the harsh regimen they were subjected to. The biochemical parameters for un-spiked control runs showed the filters to have no measurable impact on the composition of the culture media. Based on these findings, this technology seems to be quite feasible for large volume premanufacturing process culture media preparations. CI - © 2023 Takeda Manufacturing Austria AG. Biotechnology and Bioengineering published by Wiley Periodicals LLC. FAU - Wieser, Andreas AU - Wieser A AUID- ORCID: 0009-0002-8535-3093 AD - Global Pathogen Safety, Takeda Manufacturing Austria AG, Vienna, Austria. FAU - Modrof, Jens AU - Modrof J AUID- ORCID: 0000-0001-8416-7681 AD - Global Pathogen Safety, Takeda Manufacturing Austria AG, Vienna, Austria. FAU - Kreil, Thomas R AU - Kreil TR AUID- ORCID: 0000-0001-9970-0987 AD - Global Pathogen Safety, Takeda Manufacturing Austria AG, Vienna, Austria. LA - eng PT - Journal Article DEP - 20230620 PL - United States TA - Biotechnol Bioeng JT - Biotechnology and bioengineering JID - 7502021 RN - 0 (Culture Media) SB - IM MH - Animals MH - Mice MH - *Filtration/methods MH - *Viruses MH - Cell Culture Techniques MH - Drug Contamination/prevention & control MH - Culture Media OTO - NOTNLM OT - ATMP OT - biopharmaceuticals OT - media OT - nanofiltration OT - virus filtration OT - virus safety EDAT- 2023/06/20 06:42 MHDA- 2023/09/15 06:43 CRDT- 2023/06/20 05:32 PHST- 2023/05/23 00:00 [revised] PHST- 2023/04/03 00:00 [received] PHST- 2023/06/07 00:00 [accepted] PHST- 2023/09/15 06:43 [medline] PHST- 2023/06/20 06:42 [pubmed] PHST- 2023/06/20 05:32 [entrez] AID - 10.1002/bit.28473 [doi] PST - ppublish SO - Biotechnol Bioeng. 2023 Oct;120(10):2917-2924. doi: 10.1002/bit.28473. Epub 2023 Jun 20. PMID- 22753198 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20120831 LR - 20141212 IS - 1833-3516 (Print) IS - 1833-3516 (Linking) VI - 39 IP - 2 DP - 2009 Jun TI - Hyperbaric chamber attendant safety I: Doppler analysis of decompression stress in multiplace chamber attendants. PG - 63-70 AB - INTRODUCTION: Incidences of decompression sickness of 0.76% have been reported in hyperbaric attendants exposed to routine 243 kPa treatment tables. Occupational health risks of this magnitude are not acceptable in routine clinical practice. Significant variations in procedures are therefore found between institutions in an attempt to enhance staff safety. In extreme cases, the use of multiplace chambers has been abandoned. Doppler ultrasound provides an objective tool to assess the sub-clinical decompression stress associated with any particular exposure. AIMS: To assess the decompression stress imposed upon staff exposed to our routine 243 kPa table and to elucidate demographic details within the attendant population that impact upon that stress. DESIGN: prospective observational cohort study. Profile: 243 kPa for 90 min with a 20 min decompression on oxygen. SUBJECTS: 28 nursing and medical personnel routinely undertaking patient care under hyperbaric conditions. PROCEDURE: Doppler assessment at 20 min intervals for up to 120 min post-exposure. Scoring: aural grading of intravascular bubbles using the Kisman-Masurel (K-M) scoring system; 163 exposures were scrutinized in this manner. RESULTS: 68% of exposures resulted in 'low' (K-M Grades 0-I), 22% in 'intermediate' (Grade II) and 10% in 'high' sub-clinical decompression stress (Grades III-IV). Female gender and increasing age, weight and exposure frequency showed trends towards higher bubble grades. There were no cases of clinical decompression sickness. CONCLUSIONS: Our standard 243 kPa table conforms to DCIEM definitions of 'acceptable' decompression stress (Grade II or fewer bubbles in ≥50% of the subjects). Significant inter- and intra-individual variability was evident even within this one, tightly controlled dive profile. FAU - Cooper, P David AU - Cooper PD AD - Royal Hobart Hospital, Hobart, Australia. david.cooper@dhhs.tas.gov.au FAU - Van den Broek, Corry AU - Van den Broek C FAU - Smart, David R AU - Smart DR FAU - Nishi, Ron Y AU - Nishi RY FAU - Eastman, David AU - Eastman D LA - eng PT - Journal Article PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 EDAT- 2009/06/01 00:00 MHDA- 2009/06/01 00:01 CRDT- 2012/07/04 06:00 PHST- 2008/12/03 00:00 [received] PHST- 2009/03/31 00:00 [accepted] PHST- 2012/07/04 06:00 [entrez] PHST- 2009/06/01 00:00 [pubmed] PHST- 2009/06/01 00:01 [medline] PST - ppublish SO - Diving Hyperb Med. 2009 Jun;39(2):63-70. PMID- 16547674 OWN - NLM STAT- MEDLINE DCOM- 20060912 LR - 20221207 IS - 0944-1166 (Print) IS - 0944-1166 (Linking) VI - 13 IP - 2 DP - 2006 TI - Techniques of reconstruction of hepatic veins in living-donor liver transplantation, especially for right hepatic vein and major short hepatic veins of right-lobe graft. PG - 131-8 AB - Living-donor liver transplantation (LDLT) is now widely accepted as a therapeutic option for adult patients with acute and chronic end-stage liver disease. In the early period, the left lobe was the major liver graft used in adult LDLT to ensure donor safety, especially in Eastern countries. However, the frequent extremes of graft-size insufficiency in left-lobe LDLT represented a greater risk of small-for-size graft syndrome in the recipient, which has focused attention on transplantation of the right lobe from a living donor. The major concern of right-lobe LDLT has focused on its safety for the donor and the necessity for including the middle hepatic vein (MHV) in the graft to avoid congestion of the right anterior segment. The MHV carries out important venous drainage for the right anterior segment and is essential for perfect graft function. The decision of whether to take the MHV with the liver graft (extended right lobe graft) or whether to retain it in the donor, with reconstruction of the MHV tributaries in the liver graft (modified right lobe graft) has been extensively discussed in numerous studies. However, adequate right hepatic vein and major short hepatic vein (middle and inferior right hepatic vein [RHV]) drainage of the liver graft is perhaps equally important as MHV outflow drainage for the integrity of right-lobe graft function. Herein, the author describes various techniques of venoplasty of the right hepatic vein (RHV) and the major short hepatic veins to obviate venous outflow obstruction in these veins. FAU - Lee, Sung-Gyu AU - Lee SG AD - The Division of Hepatopancreatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-736, Korea. LA - eng PT - Case Reports PT - Journal Article PL - Japan TA - J Hepatobiliary Pancreat Surg JT - Journal of hepato-biliary-pancreatic surgery JID - 9431940 SB - IM MH - Adult MH - Anastomosis, Surgical MH - Female MH - Graft Occlusion, Vascular/prevention & control MH - Hepatic Veins/*surgery MH - Humans MH - Liver Transplantation/*methods MH - Living Donors MH - Plastic Surgery Procedures/*methods MH - Stents MH - Tomography, X-Ray Computed MH - Treatment Outcome MH - Vascular Patency EDAT- 2006/03/21 09:00 MHDA- 2006/09/13 09:00 CRDT- 2006/03/21 09:00 PHST- 2005/04/30 00:00 [received] PHST- 2005/05/30 00:00 [accepted] PHST- 2006/03/21 09:00 [pubmed] PHST- 2006/09/13 09:00 [medline] PHST- 2006/03/21 09:00 [entrez] AID - 10.1007/s00534-005-1019-7 [doi] PST - ppublish SO - J Hepatobiliary Pancreat Surg. 2006;13(2):131-8. doi: 10.1007/s00534-005-1019-7. PMID- 21307373 OWN - NLM STAT- MEDLINE DCOM- 20110329 LR - 20211020 IS - 1541-0048 (Electronic) IS - 0090-0036 (Print) IS - 0090-0036 (Linking) VI - 101 IP - 3 DP - 2011 Mar TI - Safety in the Heat: a comprehensive program for prevention of heat illness among workers in Abu Dhabi, United Arab Emirates. PG - 395-8 LID - 10.2105/AJPH.2009.189563 [doi] AB - The Safety in the Heat program was developed in response to the extreme heat stress conditions experienced by workers in the United Arab Emirates and other Middle Eastern countries each summer, where ambient air temperatures often reach 45°C (135°F) and higher with 90% humidity. A comprehensive, multimedia, economical education and awareness program targeting companies in the region was developed; 465 companies employing 814 996 heat-exposed workers across 6254 work and labor residence sites were reached. Feedback from program participants indicated a high level of support and satisfaction. Results indicated a marked reduction in heat related illness over a period of 2 years (2008-2009) at 2 companies, one of which reported a combined 79.5% decrease in cases (15.3 vs 1.16 cases per 1000 workers) while the other experienced a 50% reduction in serious cases (0.08-0.04 cases per 100,000 work hours). FAU - Joubert, Darren AU - Joubert D AD - Department of Public Health and Research, Health Authority, Abu Dhabi, United Arab Emirates. djoubert@haad.ae FAU - Thomsen, Jens AU - Thomsen J FAU - Harrison, Oliver AU - Harrison O LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Public Health JT - American journal of public health JID - 1254074 SB - IM MH - Female MH - Health Promotion/*organization & administration MH - Heat Stress Disorders/epidemiology/*prevention & control MH - Humans MH - Male MH - Occupational Diseases/epidemiology/*prevention & control MH - Program Development MH - Program Evaluation MH - Risk Factors MH - Seasons MH - United Arab Emirates/epidemiology PMC - PMC3036673 EDAT- 2011/02/11 06:00 MHDA- 2011/03/30 06:00 PMCR- 2013/03/01 CRDT- 2011/02/11 06:00 PHST- 2011/02/11 06:00 [entrez] PHST- 2011/02/11 06:00 [pubmed] PHST- 2011/03/30 06:00 [medline] PHST- 2013/03/01 00:00 [pmc-release] AID - 101/3/395 [pii] AID - 189563 [pii] AID - 10.2105/AJPH.2009.189563 [doi] PST - ppublish SO - Am J Public Health. 2011 Mar;101(3):395-8. doi: 10.2105/AJPH.2009.189563. PMID- 28197144 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 8 DP - 2017 TI - Detection and Enumeration of Spore-Forming Bacteria in Powdered Dairy Products. PG - 109 LID - 10.3389/fmicb.2017.00109 [doi] LID - 109 AB - With the abolition of milk quotas in the European Union in 2015, several member states including Ireland, Luxembourg, and Belgium have seen year on year bi-monthly milk deliveries to dairies increase by up to 35%. Milk production has also increased outside of Europe in the past number of years. Unsurprisingly, there has been a corresponding increased focus on the production of dried milk products for improved shelf life. These powders are used in a wide variety of products, including confectionery, infant formula, sports dietary supplements and supplements for health recovery. To ensure quality and safety standards in the dairy sector, strict controls are in place with respect to the acceptable quantity and species of microorganisms present in these products. A particular emphasis on spore-forming bacteria is necessary due to their inherent ability to survive extreme processing conditions. Traditional microbiological detection methods used in industry have limitations in terms of time, efficiency, accuracy, and sensitivity. The following review will explore the common spore-forming bacterial contaminants of milk powders, will review the guidelines with respect to the acceptable limits of these microorganisms and will provide an insight into recent advances in methods for detecting these microbes. The various advantages and limitations with respect to the application of these diagnostics approaches for dairy food will be provided. It is anticipated that the optimization and application of these methods in appropriate ways can ensure that the enhanced pressures associated with increased production will not result in any lessening of safety and quality standards. FAU - McHugh, Aoife J AU - McHugh AJ AD - Food Bioscience Department, Teagasc Food Research CentreCork, Ireland; School of Microbiology, University College CorkCork, Ireland. FAU - Feehily, Conor AU - Feehily C AD - Food Bioscience Department, Teagasc Food Research CentreCork, Ireland; APC Microbiome InstituteCork, Ireland. FAU - Hill, Colin AU - Hill C AD - School of Microbiology, University College CorkCork, Ireland; APC Microbiome InstituteCork, Ireland. FAU - Cotter, Paul D AU - Cotter PD AD - Food Bioscience Department, Teagasc Food Research CentreCork, Ireland; APC Microbiome InstituteCork, Ireland. LA - eng PT - Journal Article PT - Review DEP - 20170131 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC5281614 OTO - NOTNLM OT - dairy OT - dairy powder OT - next generation sequencing OT - pathogens OT - spore-forming bacteria EDAT- 2017/02/16 06:00 MHDA- 2017/02/16 06:01 PMCR- 2017/01/31 CRDT- 2017/02/16 06:00 PHST- 2016/07/27 00:00 [received] PHST- 2017/01/16 00:00 [accepted] PHST- 2017/02/16 06:00 [entrez] PHST- 2017/02/16 06:00 [pubmed] PHST- 2017/02/16 06:01 [medline] PHST- 2017/01/31 00:00 [pmc-release] AID - 10.3389/fmicb.2017.00109 [doi] PST - epublish SO - Front Microbiol. 2017 Jan 31;8:109. doi: 10.3389/fmicb.2017.00109. eCollection 2017. PMID- 36817056 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230224 IS - 1792-1082 (Electronic) IS - 1792-1074 (Print) IS - 1792-1074 (Linking) VI - 25 IP - 3 DP - 2023 Mar TI - Endoscopic treatment of early esophageal cancer with decompensated cirrhosis and successful prevention of postoperative stenosis: A case report. PG - 105 LID - 10.3892/ol.2023.13691 [doi] LID - 105 AB - The management of gastrointestinal tumors with decompensated cirrhosis is extremely challenging. Patients often present with poor basic condition and coagulation function, and nutritional deficiency. Furthermore, postoperative recovery is difficult and so the majority of patients refuse surgery. The present study reports the case of a 73-year-old man with decompensated cirrhosis and early esophageal cancer. At the discretion of the patient and their family, a simultaneous approach was used to treat esophagogastric varices and perform a mucosal dissection of the early esophageal cancer via endoscopy. Post-surgery, multiple polyglycolic acid sheets were attached to the esophageal dissection wound. At >2 months post-surgery, an endoscopic re-examination of the patient showed that the esophageal mucosa had healed well, and there was no resistance detected via ordinary endoscopy. The main objective of the present study was to highlight the feasibility and safety of endoscopic treatment for patients with decompensated liver cirrhosis complicated with early esophageal cancer, and to provide a new treatment strategy for patients at high risk of esophageal stenosis after endoscopic mucosal dissection. CI - Copyright: © Tian et al. FAU - Tian, Wei AU - Tian W AD - Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China. FAU - Feng, Xinxia AU - Feng X AD - Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China. FAU - Liu, Mei AU - Liu M AD - Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China. LA - eng PT - Case Reports PT - Journal Article DEP - 20230202 PL - Greece TA - Oncol Lett JT - Oncology letters JID - 101531236 PMC - PMC9933150 OTO - NOTNLM OT - case report OT - early esophageal cancer OT - liver cirrhosis OT - polyglycolic acid sheet COIS- The authors declare that they have no competing interests. EDAT- 2023/02/24 06:00 MHDA- 2023/02/24 06:01 PMCR- 2023/02/02 CRDT- 2023/02/23 09:30 PHST- 2022/09/29 00:00 [received] PHST- 2023/01/04 00:00 [accepted] PHST- 2023/02/23 09:30 [entrez] PHST- 2023/02/24 06:00 [pubmed] PHST- 2023/02/24 06:01 [medline] PHST- 2023/02/02 00:00 [pmc-release] AID - OL-25-3-13691 [pii] AID - 10.3892/ol.2023.13691 [doi] PST - epublish SO - Oncol Lett. 2023 Feb 2;25(3):105. doi: 10.3892/ol.2023.13691. eCollection 2023 Mar. PMID- 25176112 OWN - NLM STAT- MEDLINE DCOM- 20150414 LR - 20211021 IS - 1471-2482 (Electronic) IS - 1471-2482 (Linking) VI - 14 DP - 2014 Aug 30 TI - Successful treatment of aberrant splenic artery aneurysm with a combination of coils embolization and covered stents. PG - 62 LID - 10.1186/1471-2482-14-62 [doi] AB - BACKGROUND: Aneurysms of an aberrant splenic artery originating from the superior mesenteric artery (SMA) are extremely rare; however, they are clinically important because possible rupture could be catastrophic. The methods of treatment for this condition include surgical resection, minimally invasive techniques (include laparoscopic technique) and endovascular therapy. The purpose of this study is to evaluate the efficacy of coils embolization combined with covered stents to treat aberrant splenic artery aneurysm (SAA). CASES PRESENTATION: We report four consecutive cases of aberrant SAA that the aberrant splenic artery was embolized with coils and the superior mesenteric artery was excluded with a covered stent and an up-to-date review of all previous cases in the field. A follow-up computed tomography performed 6 to 12 months postoperatively showed persistent exclusion with marked shrinkage of the aneurysm sac. CONCLUSIONS: The authors believe although early results are promising, further careful follow-up will be needed to determine the long-term clinical efficacy, safety and applicability of this approach. FAU - Zhou, Weimin AU - Zhou W AD - Department of Vascular Surgery, The second affiliated hospital of Nanchang University, No 1#, Minde Road, Nanchang, China. drzwm@sina.com. FAU - Qiu, Jiehua AU - Qiu J FAU - Yuan, Qingwen AU - Yuan Q FAU - Zhou, Wei AU - Zhou W FAU - Xiong, Jixin AU - Xiong J FAU - Zeng, Qingzhong AU - Zeng Q LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20140830 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Adult MH - Aneurysm/diagnostic imaging/*therapy MH - *Blood Vessel Prosthesis MH - Embolization, Therapeutic/*methods MH - Endovascular Procedures/*methods MH - Follow-Up Studies MH - Humans MH - Male MH - *Splenic Artery MH - *Stents MH - Tomography, X-Ray Computed PMC - PMC4167310 EDAT- 2014/09/02 06:00 MHDA- 2015/04/15 06:00 PMCR- 2014/08/30 CRDT- 2014/09/02 06:00 PHST- 2013/09/22 00:00 [received] PHST- 2014/08/22 00:00 [accepted] PHST- 2014/09/02 06:00 [entrez] PHST- 2014/09/02 06:00 [pubmed] PHST- 2015/04/15 06:00 [medline] PHST- 2014/08/30 00:00 [pmc-release] AID - 1471-2482-14-62 [pii] AID - 10.1186/1471-2482-14-62 [doi] PST - epublish SO - BMC Surg. 2014 Aug 30;14:62. doi: 10.1186/1471-2482-14-62. PMID- 33709230 OWN - NLM STAT- MEDLINE DCOM- 20211123 LR - 20211123 IS - 1432-1750 (Electronic) IS - 0341-2040 (Linking) VI - 199 IP - 2 DP - 2021 Apr TI - Diffuse Alveolar Hemorrhage in Cardiac Diseases. PG - 103-112 LID - 10.1007/s00408-021-00433-x [doi] AB - Diffuse alveolar hemorrhage (DAH) is a rare condition with reported mortality ranging between 20 and 100%. There are many etiologies of DAH. Cardiac diseases are likely underreported causes of DAH. Heart failure and mitral valve diseases are the most common cardiac causes of DAH. The DAH results from pulmonary venous hypertension leading to stress failure of the pulmonary capillaries. There is also a contribution of the bronchial circulation. The Alveolar-capillary membrane or blood-gas barrier is an extremely thin structure that allows rapid and passive diffusion of oxygen from the inhaled air to the pulmonary capillaries while preventing pulmonary edema and DAH with chronic elevation of the transmural hydrostatic pressure. The purpose of this manuscript is to inform the clinician about this rare cause of DAH, which may be overlooked unless specifically sought after. We also discuss the pathophysiologic aspects of DAH and the safety mechanisms in place to prevent such occurrences. FAU - Saha, Biplab K AU - Saha BK AUID- ORCID: 0000-0002-3595-8804 AD - Division of Pulmonary and Critical Care Medicine, Ozarks Medical Center, 1100 Kentucky Avenue, West Plains, Missouri, 65775, USA. spanophiliac@yahoo.com. FAU - Chong, Woon H AU - Chong WH AD - Division of Pulmonary and Critical Care Medicine, Albany Medical College, Albany, NY, 12208, USA. LA - eng PT - Journal Article PT - Review DEP - 20210311 PL - United States TA - Lung JT - Lung JID - 7701875 SB - IM MH - Heart Diseases/*complications/pathology/physiopathology MH - Hemorrhage/*diagnosis/*etiology/therapy MH - Humans MH - Lung Diseases/*diagnosis/*etiology/therapy MH - *Pulmonary Alveoli OTO - NOTNLM OT - Diffuse alveolar hemorrhage OT - Heart failure OT - Mitral regurgitation OT - Mitral stenosis EDAT- 2021/03/13 06:00 MHDA- 2021/11/24 06:00 CRDT- 2021/03/12 07:29 PHST- 2021/01/01 00:00 [received] PHST- 2021/02/26 00:00 [accepted] PHST- 2021/03/13 06:00 [pubmed] PHST- 2021/11/24 06:00 [medline] PHST- 2021/03/12 07:29 [entrez] AID - 10.1007/s00408-021-00433-x [pii] AID - 10.1007/s00408-021-00433-x [doi] PST - ppublish SO - Lung. 2021 Apr;199(2):103-112. doi: 10.1007/s00408-021-00433-x. Epub 2021 Mar 11. PMID- 8853934 OWN - NLM STAT- MEDLINE DCOM- 19970131 LR - 20181113 IS - 0312-5963 (Print) IS - 0312-5963 (Linking) VI - 31 IP - 2 DP - 1996 Aug TI - Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring. PG - 120-30 AB - The ability to measure the serum concentrations of antiepileptic drugs, and the widespread use of this procedure, has markedly improved the treatment given to patients with epilepsy during the past 3 decades. The monitoring of antiepileptic drug concentrations in serum is necessary for the optimal drug therapy of seizures, because the therapeutic and toxic effects of these drugs are better related to serum concentration than to administered dosage. Monitoring appeared to have a major impact on improving the effectiveness and safety of antiepileptic drug therapy. The age-related variability of pharmacokinetic parameters may also require the individualisation of therapy, with subsequent re-evaluation as the person grows older. Monitoring serum concentrations of antiepileptic drugs may help to optimise the dose. A drug concentration, however, can only be regarded as a guide around which to alter the dosage according to the patient's clinical condition. Serum drug concentration monitoring is particularly useful to ensure compliance and in helping to manage combinations of antiepileptic drugs that invariably interact. The addition or deletion of other antiepileptic drugs may change dosage requirements. Therefore, routine monitoring of antiepileptic drug serum concentrations would be extremely useful, especially in the paediatric population, and in patients who require associated antiepileptic medication. FAU - Yukawa, E AU - Yukawa E AD - Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan. LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - Switzerland TA - Clin Pharmacokinet JT - Clinical pharmacokinetics JID - 7606849 RN - 0 (Anticonvulsants) RN - 33CM23913M (Carbamazepine) RN - 6158TKW0C5 (Phenytoin) RN - YQE403BP4D (Phenobarbital) SB - IM MH - Anticonvulsants/blood/*therapeutic use MH - Carbamazepine/blood/therapeutic use MH - Drug Monitoring MH - Epilepsy/blood/*drug therapy MH - Humans MH - Phenobarbital/blood/therapeutic use MH - Phenytoin/blood/therapeutic use RF - 102 EDAT- 1996/08/01 00:00 MHDA- 1996/08/01 00:01 CRDT- 1996/08/01 00:00 PHST- 1996/08/01 00:00 [pubmed] PHST- 1996/08/01 00:01 [medline] PHST- 1996/08/01 00:00 [entrez] AID - 10.2165/00003088-199631020-00004 [doi] PST - ppublish SO - Clin Pharmacokinet. 1996 Aug;31(2):120-30. doi: 10.2165/00003088-199631020-00004. PMID- 37385269 OWN - NLM STAT- MEDLINE DCOM- 20230724 LR - 20230724 IS - 2352-4650 (Electronic) IS - 2352-4642 (Linking) VI - 7 IP - 8 DP - 2023 Aug TI - Inhaled corticosteroids to improve lung function in children (aged 6-12 years) who were born very preterm (PICSI): a randomised, double-blind, placebo-controlled trial. PG - 567-576 LID - S2352-4642(23)00128-1 [pii] LID - 10.1016/S2352-4642(23)00128-1 [doi] AB - BACKGROUND: Despite the substantial burden of lung disease throughout childhood in children who were born very preterm, there are no evidence-based interventions to improve lung health beyond the neonatal period. We tested the hypothesis that inhaled corticosteroid improves lung function in this population. METHODS: PICSI was a randomised, double-blind, placebo-controlled trial at Perth Children's Hospital (Perth, WA, Australia) to assess whether fluticasone propionate, an inhaled corticosteroid, improves lung function in children who had been born very preterm (<32 weeks of gestation). Eligible children were aged 6-12 years and did not have severe congenital abnormalities, cardiopulmonary defects, neurodevelopmental impairment, diabetes, or any glucocorticoid use within the preceding 3 months. Participants were randomly assigned (1:1) to receive 125 μg fluticasone propionate or placebo twice daily for 12 weeks. Participants were stratified for sex, age, bronchopulmonary dysplasia diagnosis, and recent respiratory symptoms using the biased-coin minimisation technique. The primary outcome was change in pre-bronchodilator forced expiratory volume in 1 s (FEV(1)) after 12 weeks of treatment. Data were analysed by intention-to-treat (ie, all participants who were randomly assigned and took at least the tolerance dose of the drug). All participants were included in the safety analyses. This trial is registered at the Australian and New Zealand Clinical Trials Registry, number 12618000781246. FINDINGS: Between Oct 23, 2018, and Feb 4, 2022, 170 participants were randomly assigned and received at least the tolerance dose (83 received placebo and 87 received inhaled corticosteroid). 92 (54%) participants were male and 78 (46%) were female. 31 participants discontinued treatment before 12 weeks (14 in the placebo group and 17 in the inhaled corticosteroid group), mostly due to the impact of the COVID-19 pandemic. When analysed by intention-to-treat, the change in pre-bronchodilator FEV(1) Z score over 12 weeks was -0·11 (95% CI -0·21 to 0·00) in the placebo group and 0·20 (0·11 to 0·30) in the inhaled corticosteroid group (imputed mean difference 0·30, 0·15-0·45). Three of 83 participants in the inhaled corticosteroid group had adverse events requiring treatment discontinuation (exacerbation of asthma-like symptoms). One of 87 participants in the placebo group had an adverse event requiring treatment discontinuation (inability to tolerate the treatment with dizziness, headaches, stomach pains, and worsening of a skin condition). INTERPRETATION: As a group, children born very preterm have only modestly improved lung function when treated with inhaled corticosteroid for 12 weeks. Future studies should consider individual phenotypes of lung disease after preterm birth and other agents to improve management of prematurity-associated lung disease. FUNDING: Australian National Health and Medical Research Council, Telethon Kids Institute, and Curtin University. CI - Copyright © 2023 Elsevier Ltd. All rights reserved. FAU - Urs, Rhea C AU - Urs RC AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia. FAU - Evans, Denby J AU - Evans DJ AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; School of Population Science, Curtin University, Perth, WA, Australia. FAU - Bradshaw, Tiffany K AU - Bradshaw TK AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia. FAU - Gibbons, James T D AU - Gibbons JTD AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; Department of Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, WA, Australia. FAU - Smith, Elizabeth F AU - Smith EF AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia. FAU - Foong, Rachel E AU - Foong RE AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia. FAU - Wilson, Andrew C AU - Wilson AC AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; Department of Respiratory and Sleep Medicine, Perth Children's Hospital, Perth, WA, Australia. FAU - Simpson, Shannon J AU - Simpson SJ AD - Children's Lung Health, Wal-Yan Respiratory Research Centre, Telethon Kids Institute, Perth, WA, Australia; Curtin School of Allied Health, Faculty of Health Sciences, Curtin University, Perth, WA, Australia. Electronic address: shannon.simpson@telethonkids.org.au. LA - eng SI - ANZCTR/ACTRN12618000781246 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20230626 PL - England TA - Lancet Child Adolesc Health JT - The Lancet. Child & adolescent health JID - 101712925 RN - 0 (Bronchodilator Agents) RN - CUT2W21N7U (Fluticasone) RN - 0 (Adrenal Cortex Hormones) SB - IM CIN - Lancet Child Adolesc Health. 2023 Aug;7(8):523-524. doi: 10.1016/S2352-4642(23)00139-6. PMID: 37385268 MH - Infant, Newborn MH - Male MH - Child MH - Humans MH - Female MH - Bronchodilator Agents/therapeutic use MH - Infant, Extremely Premature MH - Pandemics MH - Australia/epidemiology MH - *COVID-19 MH - *Premature Birth MH - Fluticasone/therapeutic use MH - Adrenal Cortex Hormones MH - Lung COIS- Declaration of interests SJS received funding from the Australian National Health and Medical Research Council to conduct this study. All other authors declare no competing interests. EDAT- 2023/06/30 01:06 MHDA- 2023/07/24 06:43 CRDT- 2023/06/29 18:52 PHST- 2022/12/06 00:00 [received] PHST- 2023/04/21 00:00 [revised] PHST- 2023/04/26 00:00 [accepted] PHST- 2023/07/24 06:43 [medline] PHST- 2023/06/30 01:06 [pubmed] PHST- 2023/06/29 18:52 [entrez] AID - S2352-4642(23)00128-1 [pii] AID - 10.1016/S2352-4642(23)00128-1 [doi] PST - ppublish SO - Lancet Child Adolesc Health. 2023 Aug;7(8):567-576. doi: 10.1016/S2352-4642(23)00128-1. Epub 2023 Jun 26. PMID- 20734671 OWN - NLM STAT- MEDLINE DCOM- 20101005 LR - 20131121 IS - 0324-0959 (Print) IS - 0324-0959 (Linking) VI - 49 IP - 2 DP - 2010 TI - [Early parenteral nutrition with very low and extremely low birth weight infants--practical approach]. PG - 3-13 AB - Newborn infants with birth weight 1500 g and less (VLBW/ELBW) have higher nutritional needs, but enteral feeding is often insufficient or impossible. Parenteral nutrition (PN) as an important component of intensive care with them minimizes the risk of nutritional deficiency. OBJECTIVE: To evaluate the safety and efficacy of early PN administration in VLBW/ELBW infants. STUDY DESIGN: The prospective study includes 23 newborn babies with birthweight below 1500 g who were admitted to the NICU from 01.03. to 20.04. 2009. With all babies a PN was started from the first day of life with dextrose and amino acid solutions, adding lipid solutions in gradually increasing quantity on the second day. During the first 20 days of life for each baby were calculated on a daily basis the exact quantities of energy and the essential nutritional substances as well as the balance among them. All babies were followed up for weight gain, presence or absence of complications, related with parenteral nutrition as well as for: blood sugar, acid-base status, total serum protein, electrolytes, urea, triglycerides, billirubin, alkaline phosphatase, ASAT ALAT RESULTS: We found that due to the small infusion volumes during the first days, the minimal daily needed nutrition levels are reached at day 4-5. Nutritional intake at day 7-10 in most children is enough for growth. A positive mean weight gain for the whole group 6.6 g/kg/d (SD 6.2) is observed. Negative weight gain during the first 20 days is observed only with two critically ill babies with substantial reduction of infusion volume. In 9 babies a transient increase in urea levels was observed during the first week, 5 babies had an increase in triglycerides as a symptom of bad lipid tolerance. In 7 babies on prolonged total PN an increase in alkaline phosphatase is observed. Conclusions. Early and sufficient PN in newborn babies below 1500 g guarantees the daily intake of energy and essential nutritive substances for adequate growth and is a basic component of intensive therapy. It should be corresponding to the nutritional needs as well as to the clinical condition; matching the severity of complications and carried under strict laboratory control. FAU - Vakrilova, L AU - Vakrilova L FAU - Sluncheva, B AU - Sluncheva B FAU - Emilova, Z AU - Emilova Z FAU - Pramatarova, T AU - Pramatarova T FAU - Jarukova, N AU - Jarukova N FAU - Radulova, P AU - Radulova P FAU - Chitrova, S AU - Chitrova S FAU - Petrova, G AU - Petrova G LA - bul PT - English Abstract PT - Journal Article PL - Bulgaria TA - Akush Ginekol (Sofiia) JT - Akusherstvo i ginekologiia JID - 0370455 RN - 0 (Amino Acids) RN - 0 (Lipids) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Amino Acids/administration & dosage MH - Glucose/administration & dosage MH - Humans MH - Infant, Extremely Low Birth Weight/*growth & development MH - Infant, Newborn MH - Infant, Very Low Birth Weight/*growth & development MH - Lipids/administration & dosage MH - *Parenteral Nutrition MH - Prospective Studies MH - Weight Gain EDAT- 2010/08/26 06:00 MHDA- 2010/10/06 06:00 CRDT- 2010/08/26 06:00 PHST- 2010/08/26 06:00 [entrez] PHST- 2010/08/26 06:00 [pubmed] PHST- 2010/10/06 06:00 [medline] PST - ppublish SO - Akush Ginekol (Sofiia). 2010;49(2):3-13. PMID- 28155804 OWN - NLM STAT- MEDLINE DCOM- 20170823 LR - 20190320 IS - 1475-2654 (Electronic) IS - 1466-2523 (Linking) VI - 17 IP - 2 DP - 2016 Dec TI - The pathogenesis of proventricular dilatation disease. PG - 110-126 LID - 10.1017/S1466252316000189 [doi] AB - Bornaviruses cause neurologic diseases in several species of birds, especially parrots, waterfowl and finches. The characteristic lesions observed in these birds include encephalitis and gross dilatation of the anterior stomach - the proventriculus. The disease is thus known as proventricular dilatation disease (PDD). PDD is characterized by extreme proventricular dilatation, blockage of the passage of digesta and consequent death by starvation. There are few clinical resemblances between this and the bornaviral encephalitides observed in mammals. Nevertheless, there are common virus-induced pathogenic pathways shared across this disease spectrum that are explored in this review. Additionally, a review of the literature relating to gastroparesis in humans and the control of gastric mobility in mammals and birds points to several plausible mechanisms by which bornaviral infection may result in extreme proventricular dilatation. FAU - Tizard, Ian AU - Tizard I AUID- ORCID: 0000-0001-5311-2581 AD - Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA. FAU - Shivaprasad, H L AU - Shivaprasad HL AD - University of California Animal Health and Food Safety Laboratory System-Tulare, University of California,Davis,Tulare, CA,USA. FAU - Guo, Jianhua AU - Guo J AD - Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA. FAU - Hameed, Samer AU - Hameed S AD - Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA. FAU - Ball, Judith AU - Ball J AD - Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA. FAU - Payne, Susan AU - Payne S AD - Department of Veterinary Pathobiology and the Schubot Exotic Bird Health Center,Texas A&M University,College Station,TX 77843,USA. LA - eng PT - Journal Article PT - Review PL - England TA - Anim Health Res Rev JT - Animal health research reviews JID - 101083072 SB - IM MH - Animals MH - Bird Diseases/*virology MH - Birds MH - *Bornaviridae MH - Dilatation MH - Mononegavirales Infections/pathology/*veterinary MH - Proventriculus/*virology OTO - NOTNLM OT - Proventricular dilatation disease OT - achalasia OT - myenteric plexus OT - parrot bornavirus OT - vagus nerve EDAT- 2017/02/06 06:00 MHDA- 2019/03/21 06:00 CRDT- 2017/02/04 06:00 PHST- 2017/02/04 06:00 [entrez] PHST- 2017/02/06 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] AID - S1466252316000189 [pii] AID - 10.1017/S1466252316000189 [doi] PST - ppublish SO - Anim Health Res Rev. 2016 Dec;17(2):110-126. doi: 10.1017/S1466252316000189. PMID- 35391509 OWN - NLM STAT- MEDLINE DCOM- 20220411 LR - 20220411 IS - 0412-4081 (Print) IS - 0412-4081 (Linking) VI - 58 IP - 4 DP - 2022 Apr 11 TI - [Paying extremely high attention to customized option and visual quality evaluation of refractive surgery]. PG - 241-244 LID - 10.3760/cma.j.cn112142-20220115-00018 [doi] AB - As one of the methods to correct ametropia, refractive surgery has been accepted by more and more patients for its good safety, effectiveness and long-term stability. The two major types of refractive surgery are corneal refractive surgery, which is mainly performed with excimer laser and/or femtosecond laser, and phakic intraocular lens implantation. Each type has its own advantages and disadvantages. Surgeons should choose the best method according to their own technical conditions and the individual situation of each patient. In the preoperative and postoperative evaluation, we should not only pay attention to uncorrected vision and refraction, but also carry out a comprehensive visual quality assessment from both subjective and objective aspects. The ultimate goal of refractive surgery is to maximize patient satisfaction. FAU - Chen, Y G AU - Chen YG AD - Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China. FAU - Liu, Y AU - Liu Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China. LA - chi PT - Journal Article PL - China TA - Zhonghua Yan Ke Za Zhi JT - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology JID - 16210540R SB - IM MH - Humans MH - Lasers, Excimer MH - Lens Implantation, Intraocular MH - *Lenses, Intraocular MH - *Myopia/surgery MH - Refraction, Ocular MH - *Refractive Surgical Procedures MH - Visual Acuity EDAT- 2022/04/09 06:00 MHDA- 2022/04/12 06:00 CRDT- 2022/04/08 01:55 PHST- 2022/04/08 01:55 [entrez] PHST- 2022/04/09 06:00 [pubmed] PHST- 2022/04/12 06:00 [medline] AID - 10.3760/cma.j.cn112142-20220115-00018 [doi] PST - ppublish SO - Zhonghua Yan Ke Za Zhi. 2022 Apr 11;58(4):241-244. doi: 10.3760/cma.j.cn112142-20220115-00018. PMID- 6657738 OWN - NLM STAT- MEDLINE DCOM- 19840214 LR - 20180214 IS - 0031-7012 (Print) IS - 0031-7012 (Linking) VI - 27 Suppl 1 DP - 1983 TI - Clinical evaluation of suprofen in the treatment of elderly patients with pain of diverse etiology. PG - 81-6 AB - This 4-week, open design study was conducted to evaluate the efficacy and safety of suprofen (200-1,200 mg/day) in the treatment of elderly patients with pain of diverse origin, all of whom suffered from secondary disorders. All patients reported pain of moderate to very severe intensity upon study enrollment, which improved considerably in 89% of patients by week 1. 12 of the 16 patients reported good to very good pain reduction by week 4. Suprofen was extremely well tolerated by this patient population, and there were no drug-related study withdrawals. These results show suprofen to be a potentially useful drug for the treatment of elderly patients suffering from various painful conditions. FAU - Denis, F R AU - Denis FR FAU - de Beer, J M AU - de Beer JM LA - eng PT - Journal Article PL - Switzerland TA - Pharmacology JT - Pharmacology JID - 0152016 RN - 0 (Phenylpropionates) RN - 988GU2F9PE (Suprofen) SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Pain/*drug therapy/etiology MH - Phenylpropionates/*therapeutic use MH - Suprofen/adverse effects/*therapeutic use MH - Time Factors EDAT- 1983/01/01 00:00 MHDA- 1983/01/01 00:01 CRDT- 1983/01/01 00:00 PHST- 1983/01/01 00:00 [pubmed] PHST- 1983/01/01 00:01 [medline] PHST- 1983/01/01 00:00 [entrez] AID - 10.1159/000137903 [doi] PST - ppublish SO - Pharmacology. 1983;27 Suppl 1:81-6. doi: 10.1159/000137903. PMID- 21985710 OWN - NLM STAT- MEDLINE DCOM- 20111103 LR - 20211020 IS - 1086-8089 (Print) IS - 1938-3797 (Electronic) IS - 1086-8089 (Linking) VI - 15 IP - 3 DP - 2011 Jul-Sep TI - Shakespeare's view of the laparoscopic pneumoperitoneum. PG - 282-4 LID - 10.4293/108680811X13071180407276 [doi] AB - BACKGROUND: The laparoscopic pneumoperitoneum is created and maintained in a physiologically homeostatic potential space that is 37-degrees Centigrade (°C) and covered by a wet film of peritoneal fluid. The currently used gas is carbon dioxide that is instilled at 21°C and extremely dry. Altering this privileged space is a violation of surgical safety, principles, and reason. Maintaining normal healthy conditions in their original state by humidifying and warming the gas eliminates the rub of dry gas and takes arms against a sea of troubles. DATABASE: Literature search using PubMed and Cochrane databases identifying articles focusing on laparoscopy, pneumoperitoneum, hypothermia, evaporation, desiccation, peritoneum, and morphology. CONCLUSIONS: Shakespeare's premonitions regarding the chilling effects and intentionally induced unhappy events perpetrated on the peritoneal cavity is not nor cannot come to good. The absence of water in the gas going into a wetted cavity causes perilous circumstances, resulting in evaporative hypothermia, tissue desiccation, and damage that precede adhesion formation. Providing the most protective canopy for the intraabdominal cavity with humidity and warmth prevents calamitous clinical outcomes and mirrors nature's intent. The virtue is in doing no harm. FAU - Ott, Douglas E AU - Ott DE AD - Mercer University, School of Engineering, Macon, Georgia, USA. gabiomed@mindspring.com LA - eng PT - Journal Article PL - United States TA - JSLS JT - JSLS : Journal of the Society of Laparoendoscopic Surgeons JID - 100884618 SB - IM MH - Desiccation MH - Humans MH - Humidity MH - Hypothermia, Induced MH - *Pneumoperitoneum, Artificial/methods PMC - PMC3183548 EDAT- 2011/10/12 06:00 MHDA- 2011/11/04 06:00 PMCR- 2011/07/01 CRDT- 2011/10/12 06:00 PHST- 2011/10/12 06:00 [entrez] PHST- 2011/10/12 06:00 [pubmed] PHST- 2011/11/04 06:00 [medline] PHST- 2011/07/01 00:00 [pmc-release] AID - 11-01-023 [pii] AID - 10.4293/108680811X13071180407276 [doi] PST - ppublish SO - JSLS. 2011 Jul-Sep;15(3):282-4. doi: 10.4293/108680811X13071180407276. PMID- 17878624 OWN - NLM STAT- MEDLINE DCOM- 20071025 LR - 20190608 IS - 0019-8366 (Print) IS - 0019-8366 (Linking) VI - 45 IP - 4 DP - 2007 Aug TI - Evaluation of auditory fatigue in combined noise, heat and workload exposure. PG - 527-34 AB - This study was performed in a climatic chamber to evaluate the combined effects of noise intensity, heat stress, workload, and exposure duration on both noise-induced temporary threshold shift (TTS) and the recovery time by adopting Taguch's method. Fourteen subjects without previous significant noise exposure and smoking history were recruited to participate in this study. All hearing threshold levels at eight different frequencies (250 to 8,000 Hz) of better ear were measured in an audiometric booth by using the ascending method in 2 dB steps before each exposure condition. The test was also carried out after exposure to evaluate TTS at various times. The TTS recovery time was assessed using an audiometric test on all subjects at post-exposure times of 2, 20, 40, 60, 80 and 120 min, respectively. It was found that TTS depended mainly on the exposed noise dose and was enhanced by workload and heat stress. The TTS recovery time is dependent upon the magnitude of the initial hearing loss. In conclusion, TTS driven by noise exposure is enhanced by heat and workload. Further studies are required to evaluate the effects of workload with extreme temperature in a workplace environment. FAU - Chen, Chiou-Jong AU - Chen CJ AD - Institute of Occupational Safety and Health, Council of Labor Affairs, Executive Yuan, Taiwan. FAU - Dai, Yu-Tung AU - Dai YT FAU - Sun, Yih-Min AU - Sun YM FAU - Lin, Yi-Chang AU - Lin YC FAU - Juang, Yow-Jer AU - Juang YJ LA - eng PT - Journal Article PL - Japan TA - Ind Health JT - Industrial health JID - 2985065R SB - IM MH - Adult MH - Auditory Fatigue/*physiology MH - Auditory Threshold MH - Female MH - *Hot Temperature MH - Humans MH - Male MH - *Noise, Occupational MH - Taiwan MH - *Workload EDAT- 2007/09/20 09:00 MHDA- 2007/10/27 09:00 CRDT- 2007/09/20 09:00 PHST- 2007/09/20 09:00 [pubmed] PHST- 2007/10/27 09:00 [medline] PHST- 2007/09/20 09:00 [entrez] AID - JST.JSTAGE/indhealth/45.527 [pii] AID - 10.2486/indhealth.45.527 [doi] PST - ppublish SO - Ind Health. 2007 Aug;45(4):527-34. doi: 10.2486/indhealth.45.527. PMID- 37974596 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240905 IS - 8755-1225 (Print) IS - 1549-4810 (Electronic) IS - 1549-4810 (Linking) VI - 39 IP - 6 DP - 2023 Dec TI - Direct Oral Anticoagulants for the Treatment of Venous Thromboembolism in Obesity. PG - 269-273 LID - 10.1177/87551225231196748 [doi] AB - Background: Direct oral anticoagulants (DOACs) are known to have similar efficacy with a decreased risk of bleeding when compared to warfarin for the treatment of venous thromboembolism (VTE). In patients with obesity, there are limited data regarding the safety and efficacy of DOACs. Despite concerns for both under- and over-dosing patients with extremes of body weight, there are no dose adjustment recommendations in the package inserts for any of the DOACs. Objective: To evaluate the safety and efficacy of DOACs versus warfarin for the treatment of VTE in patients with obesity. Methods: This single-center, retrospective cohort study included obese patients initiated on DOAC or warfarin therapy for VTE from January 2015 to January 2022. Patients with cancer, hypercoagulable disorders, end-stage kidney disease, or pregnancy were excluded. The primary endpoint was VTE recurrence. Secondary endpoints included major and minor bleeding. Results: A total of 120 patients met criteria for inclusion. Ninety-two received DOAC therapy and 28 received warfarin. The primary endpoint occurred in 4 patients in the DOAC group and 3 patients in the warfarin group (P = 0.35). Major bleeding occurred in 2 patients. Minor bleeding events occurred in 10 (8.33%) patients. Of those, 6 (6.5%) events occurred in patients receiving a DOAC and 4 (14.3%) events occurred in patients receiving warfarin (P = 0.28). Limitations of this study include the retrospective single-center study design. Conclusions: There was a comparable risk of bleeding and recurrent VTE between DOACs and warfarin in patients initiated on therapy for VTE. CI - © The Author(s) 2023. FAU - Hattaway, Quinn AU - Hattaway Q AUID- ORCID: 0000-0003-0061-6895 AD - Department of Pharmacy, Princeton Baptist Medical Center, Birmingham, AL, USA. FAU - Starr, Jessica A AU - Starr JA AUID- ORCID: 0000-0003-2704-4372 AD - Department of Pharmacy Practice, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA. FAU - Pinner, Nathan A AU - Pinner NA AUID- ORCID: 0000-0003-1938-5951 AD - Department of Pharmacy Practice, Harrison College of Pharmacy, Auburn University, Auburn, AL, USA. LA - eng PT - Journal Article DEP - 20230904 PL - United States TA - J Pharm Technol JT - The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians JID - 8504643 PMC - PMC10640866 OTO - NOTNLM OT - DOACs OT - apixaban OT - obesity OT - rivaroxaban OT - venous thromboembolism COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2023/11/17 15:24 MHDA- 2023/11/17 15:25 PMCR- 2024/09/04 CRDT- 2023/11/17 03:52 PHST- 2023/11/17 15:25 [medline] PHST- 2023/11/17 15:24 [pubmed] PHST- 2023/11/17 03:52 [entrez] PHST- 2024/09/04 00:00 [pmc-release] AID - 10.1177_87551225231196748 [pii] AID - 10.1177/87551225231196748 [doi] PST - ppublish SO - J Pharm Technol. 2023 Dec;39(6):269-273. doi: 10.1177/87551225231196748. Epub 2023 Sep 4. PMID- 25583861 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20151208 LR - 20150113 IS - 1471-2962 (Electronic) IS - 1364-503X (Linking) VI - 373 IP - 2035 DP - 2015 Feb 28 TI - Dynamic response mitigation of floating wind turbine platforms using tuned liquid column dampers. LID - 20140079 [pii] LID - 10.1098/rsta.2014.0079 [doi] AB - In this paper, we experimentally study and compare the effects of three combinations of multiple tuned liquid column dampers (MTLCDs) on the dynamic performance of a model floating tension-leg platform (TLP) structure in a wave basin. The structural stability and safety of the floating structure during operation and maintenance is of concern for the performance of a renewable energy device that it might be supporting. The dynamic responses of the structure should thus be limited for these renewable energy devices to perform as intended. This issue is particularly important during the operation of a TLP in extreme weather conditions. Tuned liquid column dampers (TLCDs) can use the power of sloshing water to reduce surge motions of a floating TLP exposed to wind and waves. This paper demonstrates the potential of MTLCDs in reducing dynamic responses of a scaled TLP model through an experimental study. The potential of using output-only statistical markers for monitoring changes in structural conditions is also investigated through the application of a delay vector variance (DVV) marker for different conditions of control for the experiments. CI - © 2015 The Author(s) Published by the Royal Society. All rights reserved. FAU - Jaksic, V AU - Jaksic V AD - Hydraulics and Maritime Research Centre (HMRC), School of Engineering, University College Cork, Youngline Industrial Estate, Pouladuff Road, Cork, Ireland Dynamical Systems and Risk Laboratory, Civil and Environmental Engineering, School of Engineering, University College Cork, College Road, Cork, Ireland. FAU - Wright, C S AU - Wright CS AD - Hydraulics and Maritime Research Centre (HMRC), School of Engineering, University College Cork, Youngline Industrial Estate, Pouladuff Road, Cork, Ireland. FAU - Murphy, J AU - Murphy J AD - Hydraulics and Maritime Research Centre (HMRC), School of Engineering, University College Cork, Youngline Industrial Estate, Pouladuff Road, Cork, Ireland. FAU - Afeef, C AU - Afeef C AD - Department of Ocean Engineering, Indian Institute of Technology Madras, Chennai, India Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, India. FAU - Ali, S F AU - Ali SF AD - Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai, India. FAU - Mandic, D P AU - Mandic DP AD - Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2BT, UK. FAU - Pakrashi, V AU - Pakrashi V AD - Dynamical Systems and Risk Laboratory, Civil and Environmental Engineering, School of Engineering, University College Cork, College Road, Cork, Ireland v.pakrashi@ucc.ie. LA - eng PT - Journal Article PL - England TA - Philos Trans A Math Phys Eng Sci JT - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences JID - 101133385 OTO - NOTNLM OT - offshore wind energy OT - structural dynamics OT - surge motions OT - tension-leg platform OT - tuned liquid column damper OT - wave-induced vibrations EDAT- 2015/01/15 06:00 MHDA- 2015/01/15 06:01 CRDT- 2015/01/14 06:00 PHST- 2015/01/14 06:00 [entrez] PHST- 2015/01/15 06:00 [pubmed] PHST- 2015/01/15 06:01 [medline] AID - rsta.2014.0079 [pii] AID - 10.1098/rsta.2014.0079 [doi] PST - ppublish SO - Philos Trans A Math Phys Eng Sci. 2015 Feb 28;373(2035):20140079. doi: 10.1098/rsta.2014.0079. PMID- 16286523 OWN - NLM STAT- MEDLINE DCOM- 20060124 LR - 20071114 IS - 1071-7323 (Print) IS - 1071-7323 (Linking) VI - 13 IP - 10 DP - 2005 Oct TI - Obesity and cardiovascular disease risk factors in firefighters: a prospective cohort study. PG - 1756-63 AB - OBJECTIVE: Obesity, despite being a significant determinant of fitness for duty, is reaching epidemic levels in the workplace. Firefighters' fitness is important to their health and to public safety. RESEARCH METHODS AND PROCEDURES: We examined the distribution of BMI and its association with major cardiovascular disease (CVD) risk factors in Massachusetts firefighters who underwent baseline (1996) and annual medical examinations through a statewide medical surveillance program over 5 years of follow-up. We also evaluated firefighters' weight change over time. RESULTS: The mean BMI among 332 firefighters increased from 29 at baseline to 30 at the follow-up examination (2001), and the prevalence of obesity increased from 35% to 40%, respectively (p < 0.0001). In addition, the proportion of firefighters with extreme obesity increased 4-fold at follow-up (from 0.6% to 2.4%, p < 0.0001). Obese firefighters were more likely to have hypertension (p = 0.03) and low high-density lipoprotein-cholesterol (p = 0.01) at follow-up. Firefighters with extreme obesity had an average of 2.1 CVD risk factors (excluding obesity) in contrast to 1.5 CVD risk factors for normal-weight firefighters (p = 0.02). Finally, on average, normal-weight firefighters gained 1.1 pounds, whereas firefighters with BMI > or = 35 gained 1.9 pounds per year of active duty over 5 years of follow-up. DISCUSSION: Obesity is a major concern among firefighters and shows worsening trends over time. Periodic medical evaluations coupled with exercise and dietary guidelines are needed to address this problem, which threatens firefighters' health and may jeopardize public safety. FAU - Soteriades, Elpidoforos S AU - Soteriades ES AD - The Cambridge Hospital Department of Medicine, Employee and Industrial Medicine, Cambridge, MA 02139, USA. FAU - Hauser, Russ AU - Hauser R FAU - Kawachi, Ichiro AU - Kawachi I FAU - Liarokapis, Dimitrios AU - Liarokapis D FAU - Christiani, David C AU - Christiani DC FAU - Kales, Stefanos N AU - Kales SN LA - eng GR - OH03729/OH/NIOSH CDC HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Obes Res JT - Obesity research JID - 9305691 SB - IM MH - Adult MH - Body Mass Index MH - Cardiovascular Diseases/*epidemiology MH - Cohort Studies MH - Exercise MH - Fires/prevention & control MH - Humans MH - Male MH - Massachusetts/epidemiology MH - Middle Aged MH - Obesity/*epidemiology MH - *Occupations MH - Risk Factors EDAT- 2005/11/16 09:00 MHDA- 2006/01/25 09:00 CRDT- 2005/11/16 09:00 PHST- 2005/11/16 09:00 [pubmed] PHST- 2006/01/25 09:00 [medline] PHST- 2005/11/16 09:00 [entrez] AID - 13/10/1756 [pii] AID - 10.1038/oby.2005.214 [doi] PST - ppublish SO - Obes Res. 2005 Oct;13(10):1756-63. doi: 10.1038/oby.2005.214. PMID- 12741598 OWN - NLM STAT- MEDLINE DCOM- 20031204 LR - 20190720 IS - 0021-9673 (Print) IS - 0021-9673 (Linking) VI - 991 IP - 2 DP - 2003 Apr 4 TI - Safety concerns in ultrahigh pressure capillary liquid chromatography using air-driven pumps. PG - 189-96 AB - Ultrahigh pressure liquid chromatography (UHPLC) is an emerging technique which utilizes pressures higher than 10,000 p.s.i. to overcome the flow resistance imposed when using very small particles as packing materials in fused-silica capillary columns (1 p.s.i.=6894.76 Pa). This technique has demonstrated exceptionally high separation speeds and chromatographic efficiencies. However, safety is a concern when extremely high pressures are used. In this study, the safety aspects of capillary column rupture during operation were identified and carefully evaluated. First, liquid jets may be formed as a result of blow-out of the on-column frits or from rupture of the capillary at or near the column inlet. Second, incorrect installation of the capillary at the injector, failure of the ferrule used in the capillary connection, or rupture of the capillary can produce high speed projectiles of silica particles or column fragments. Experiments were carried out in the laboratory to produce liquid (water) jets and capillary projectiles using a UHPLC system, and the power density, an important parameter describing water jets in industrial practice, was calculated. Experimental results were in accordance with theoretical calculations. Both indicated that water jets and capillary projectiles under ultrahigh pressures might lead to skin penetration under limited conditions. The use of a plexiglass shroud to cover an initial length of the installed capillary column can eliminate any safety-related concerns about liquid jets or capillary projectiles. FAU - Xiang, Yanqiao AU - Xiang Y AD - Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602-5700, USA. FAU - Maynes, Daniel R AU - Maynes DR FAU - Lee, Milton L AU - Lee ML LA - eng PT - Journal Article PL - Netherlands TA - J Chromatogr A JT - Journal of chromatography. A JID - 9318488 SB - IM MH - Air MH - Chromatography, High Pressure Liquid/instrumentation/*methods MH - *Equipment and Supplies EDAT- 2003/05/14 05:00 MHDA- 2003/12/05 05:00 CRDT- 2003/05/14 05:00 PHST- 2003/05/14 05:00 [pubmed] PHST- 2003/12/05 05:00 [medline] PHST- 2003/05/14 05:00 [entrez] AID - S0021-9673(03)00171-7 [pii] AID - 10.1016/s0021-9673(03)00171-7 [doi] PST - ppublish SO - J Chromatogr A. 2003 Apr 4;991(2):189-96. doi: 10.1016/s0021-9673(03)00171-7. PMID- 34846793 OWN - NLM STAT- MEDLINE DCOM- 20220211 LR - 20220531 IS - 1526-4998 (Electronic) IS - 1526-498X (Linking) VI - 78 IP - 3 DP - 2022 Mar TI - A fungal Bipolaris bicolor strain as a potential bioherbicide for goosegrass (Eleusine indica) control. PG - 1251-1264 LID - 10.1002/ps.6742 [doi] AB - BACKGROUND: Tea, one of the most important commercial crops on earth, is strongly affected by weeds on productivity and quality. Bioherbicides are shedding new light on weed control in tea gardens in an economical and safe manner. RESULTS: A pathogenic strain SYNJC-2-2 was isolated from diseased leaves of a noxious weed, goosegrass (Eleusine indica), from a tea garden in Zhejiang Province, China. It was identified as the fungal species Bipolaris bicolor based on the morphological characteristics and phylogenetic analysis. The potential of the B. bicolor strain SYNJC-2-2 as a bioherbicide was assessed by determining its efficacy to control weeds and selectivity to crops, its infection process and the influence of environmental conditions on conidial production and germination. The ED(90) (effective dose of conidia resulting in 90 disease index) of SYNJC-2-2 on goosegrass was 2 × 10(4) conidia mL(-1) . Additionally, three Poaceae weeds, Setaria viridis, Microstegium vimineum and Pennisetum alopecuroides, were also extremely susceptible to SYNJC-2-2. SYNJC-2-2 was safe to 14 out of 17 crop species in nine families, especially tea plants. Conidial germination, hyphal growth and appressorial formation occurred within 3 to 6 h on goosegrass leaves. Hyphae invaded leaf tissues mainly through epidermal cell junctions and cracks, causing cell death and necrotic lesions within 2 days on inoculated leaves and killing goosegrass plants within 7 days. Furthermore, SYNJC-2-2 has a strong adaptability to environmental variables and high conidial production capacity on goosegrass juice agar media. CONCLUSION: Bipolaris bicolor strain SYNJC-2-2 has the potential to be developed as a bioherbicide for controlling goosegrass, especially in tea gardens. CI - © 2021 Society of Chemical Industry. FAU - Xiao, Wan AU - Xiao W AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. FAU - Li, Jingjing AU - Li J AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. FAU - Zhang, Yaxin AU - Zhang Y AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. FAU - Guo, Yanjing AU - Guo Y AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. FAU - Fang, Wanping AU - Fang W AUID- ORCID: 0000-0003-3325-1300 AD - Tea Science Research Institute, Nanjing Agricultural University, Nanjing, China. FAU - Valverde, Bernal E AU - Valverde BE AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. AD - Research and Development in Tropical Agriculture, Alajuela, Costa Rica. FAU - Yin, Juan AU - Yin J AD - Jiangsu Xinpin Tea Co., Ltd, Changzhou, China. FAU - Qiang, Sheng AU - Qiang S AUID- ORCID: 0000-0003-1183-9453 AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. FAU - Chen, Shiguo AU - Chen S AUID- ORCID: 0000-0002-8762-1373 AD - Weed Research Laboratory, Nanjing Agricultural University, Nanjing, China. LA - eng GR - Earmarked Fund for China Agriculture Research System (CARS-19)/ GR - Priority Academic Program Development of Jiangsu Higher Education Institutions/ GR - Science and Technology Support Program (Agriculture) of Changzhou (CE20192013)/ GR - the National Key Research and Development Program (2017YFD0201300)/ PT - Journal Article DEP - 20211214 PL - England TA - Pest Manag Sci JT - Pest management science JID - 100898744 RN - 0 (Biological Control Agents) RN - Bipolaris bicolor SB - IM MH - *Biological Control Agents MH - *Bipolaris MH - *Eleusine MH - Phylogeny MH - *Weed Control OTO - NOTNLM OT - bioherbicide OT - crop safety OT - disease index OT - infection OT - plant pathogen EDAT- 2021/12/01 06:00 MHDA- 2022/02/12 06:00 CRDT- 2021/11/30 12:36 PHST- 2021/11/26 00:00 [revised] PHST- 2021/09/07 00:00 [received] PHST- 2021/11/30 00:00 [accepted] PHST- 2021/12/01 06:00 [pubmed] PHST- 2022/02/12 06:00 [medline] PHST- 2021/11/30 12:36 [entrez] AID - 10.1002/ps.6742 [doi] PST - ppublish SO - Pest Manag Sci. 2022 Mar;78(3):1251-1264. doi: 10.1002/ps.6742. Epub 2021 Dec 14. PMID- 2357989 OWN - NLM STAT- MEDLINE DCOM- 19900801 LR - 20190828 IS - 0301-5548 (Print) IS - 0301-5548 (Linking) VI - 60 IP - 4 DP - 1990 TI - Occupational performance of a paced secondary task under conditions of sensory deprivation. II. The influence of professional training. PG - 315-20 AB - Twelve truck drivers operated the train function safety circuit (SIFA), a paced secondary task used as a job monitor on German railways engines, under laboratory conditions of extreme monotony, in a comparison with 12 train drivers who were well acquainted with SIFA. Alertness was determined by means of EEG evaluations. Heart rate was monitored as the parameter for physical load, and the precoded SIFA tasks as the active response parameter. In spite of significantly more frequent and more distinct decreases in alterness, the SIFA-trained subjects (TS) performed better. Nine out of 12 TS reached the stage of light sleep at least once during the experimental run, as compared to 4 out of 12 untrained subjects (US). Nevertheless, the ratio acoustic warnings/occurrence of light sleep was significantly lower in TS (P less than 0.01), and there were three operational errors (equivalent to emergency braking) in US. Whereas US received fewer acoustic warnings in the stages of slightly reduced altertness, this trend was reversed as soon as low frequency theta-activity appeared in the EEG. A time-related calculation of the cross-correlation coefficients between SIFA operation, alpha-activity, theta-EEG-activity, and heart rate showed that timing of SIFA operation interrupting phases of light sleep correlated significantly and positively with increases in heart rate. The results suggest that a mechanism of rhythmic central nervous arousal interrupting phases of decreased alertness/drowsiness can be learned, whereas the physiological consequences of the effort to prevent the deterioration of performance under conditions of monotony are not reduced by professional adaptation. FAU - Peter, J H AU - Peter JH AD - Zeitreihenlabor, Medizinische Poliklinik, Zentrum für Innere Medizin, Marburg, Federal Republic of Germany. FAU - Cassel, W AU - Cassel W FAU - Ehrig, B AU - Ehrig B FAU - Faust, M AU - Faust M FAU - Fuchs, E AU - Fuchs E FAU - Langanke, P AU - Langanke P FAU - Meinzer, K AU - Meinzer K FAU - Pfaff, U AU - Pfaff U LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Germany TA - Eur J Appl Physiol Occup Physiol JT - European journal of applied physiology and occupational physiology JID - 0410266 SB - IM MH - Automobile Driving MH - Electroencephalography MH - Environmental Exposure MH - Heart Rate/*physiology MH - Humans MH - *Learning MH - Motor Activity/physiology MH - Random Allocation MH - Sensory Deprivation/*physiology MH - Stress, Physiological/etiology MH - *Task Performance and Analysis OID - NASA: 90292045 EDAT- 1990/01/01 00:00 MHDA- 1990/01/01 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1990/01/01 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] AID - 10.1007/BF00379403 [doi] PST - ppublish SO - Eur J Appl Physiol Occup Physiol. 1990;60(4):315-20. doi: 10.1007/BF00379403. PMID- 26790564 OWN - NLM STAT- MEDLINE DCOM- 20180308 LR - 20181113 IS - 1440-0960 (Electronic) IS - 0004-8380 (Print) IS - 0004-8380 (Linking) VI - 58 IP - 2 DP - 2017 May TI - Topical pine tar: History, properties and use as a treatment for common skin conditions. PG - 80-85 LID - 10.1111/ajd.12427 [doi] AB - Pine tar is the end product of pine wood carbonisation following distillation using extreme heat. An extensive literature search was conducted back to the 1950s for this review. Pine tar has been used in medicine for more than 2000 years to treat a range of skin conditions because of its soothing and antiseptic properties. Pine tar should not be confused with coal tar, which has been produced from coal for approximately a hundred years. Pine tar is thought to exert its effect by reducing DNA synthesis and mitotic activity, which promotes a return to normal keratinisation. In addition, pine tar has been shown to be antipruritic, anti-inflammatory, antibacterial and antifungal. These properties make pine tar suitable for the topical treatment of eczema, psoriasis, seborrhoeic dermatitis and other dry, itchy, flaky or inflamed skin conditions. Topical products available over-the-counter in Australia today contain up to 2.3% pine tar, and come in several different formulations that can be used on the entire body, including the face. Modern day pine tar is manufactured with increased purity to eliminate toxic phenol and carcinogenic components, which have been of concern in the past. Primary irritation is uncommon. In conclusion, the long experience with topical pine tar therapy and its worldwide usage, together with the evidence presented in this review, suggests that pine tar is an effective treatment with minimal safety risk. CI - © 2016 The Authors. Australasian Journal of Dermatology © 2016 The Australasian College of Dermatologists. FAU - Barnes, Tanya M AU - Barnes TM AD - Ego Pharmaceuticals, Braeside, Victoria, Australia. FAU - Greive, Kerryn A AU - Greive KA AD - Ego Pharmaceuticals, Braeside, Victoria, Australia. LA - eng PT - Historical Article PT - Journal Article PT - Review DEP - 20160120 PL - Australia TA - Australas J Dermatol JT - The Australasian journal of dermatology JID - 0135232 RN - 0 (Resins, Plant) RN - 88S87KL877 (rosin) SB - IM MH - Administration, Cutaneous MH - History, 20th Century MH - History, 21st Century MH - History, Ancient MH - Humans MH - Resins, Plant/chemistry/history/pharmacology/*therapeutic use MH - Skin Diseases/*drug therapy PMC - PMC5434829 OTO - NOTNLM OT - coal tar OT - eczema OT - pine tar OT - psoriasis OT - seborrhoeic dermatitis EDAT- 2016/01/23 06:00 MHDA- 2018/03/09 06:00 PMCR- 2017/05/17 CRDT- 2016/01/22 06:00 PHST- 2015/09/03 00:00 [received] PHST- 2015/10/25 00:00 [accepted] PHST- 2016/01/23 06:00 [pubmed] PHST- 2018/03/09 06:00 [medline] PHST- 2016/01/22 06:00 [entrez] PHST- 2017/05/17 00:00 [pmc-release] AID - AJD12427 [pii] AID - 10.1111/ajd.12427 [doi] PST - ppublish SO - Australas J Dermatol. 2017 May;58(2):80-85. doi: 10.1111/ajd.12427. Epub 2016 Jan 20. PMID- 32226059 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210119 IS - 0001-5814 (Print) IS - 0001-5814 (Electronic) IS - 0001-5814 (Linking) VI - 44 IP - 3 DP - 2013 Jul-Sep TI - [Emerging infectious diseases in the context of blood safety]. PG - 284-293 LID - 10.1016/j.achaem.2013.07.022 [doi] AB - The risk of transfusion-related infectious diseases, the markers for which are routinely tested, is extremely low. Recently, however, blood transfusion service faces the challenge from emerging infectious diseases (EIDs), mainly zoonotic origin. Pathogens are microorganisms, mostly viruses, that usually require vectors for their transmission to humans. The relation of some EIDs to transfusion has been proved, in other cases it is considered likely. The paper presents views on EIDs etiology and spread and explains the epidemiologic basic terminology. It describes the principles and methods of EIDs risk assessment as well as prioritization of EIDs with regard to transfusion risk. It outlines the principles of international cooperation and rapid response to newly emerging threats. More attention is devoted to such diseases as West Nile fever, malaria, dengue and chikungunya which are recently a real epidemiological threat. Preventive measures to reduce the threat of EIDs transmission have also been discussed as well as their impact on the safety and supply of blood and blood components. CI - Copyright © 2013 Polskie Towarzystwo Hematologów i Transfuzjologów, Instytut Hematologii i Transfuzjologii. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved. FAU - Pogłód, Ryszard AU - Pogłód R AD - Instytut Hematologii i Transfuzjologii, Dyrektor: prof. dr hab n.med. Krzysztof Warzocha, Warszawa, Polska. FAU - Rosiek, Aleksandra AU - Rosiek A AD - Instytut Hematologii i Transfuzjologii, Dyrektor: prof. dr hab n.med. Krzysztof Warzocha, Warszawa, Polska. FAU - Łętowska, Magdalena AU - Łętowska M AD - Instytut Hematologii i Transfuzjologii, Dyrektor: prof. dr hab n.med. Krzysztof Warzocha, Warszawa, Polska. LA - pol PT - English Abstract PT - Journal Article PT - Review TT - Nowo pojawiające się choroby zakaźne w aspekcie bezpieczeństwa krwi. DEP - 20130719 PL - Poland TA - Acta Haematol Pol JT - Acta haematologica Polonica JID - 0262610 PMC - PMC7094095 OTO - NOTNLM OT - Blood safety OT - Blood transmitted infectious disease OT - Donor deferral OT - Emerging infectious diseases (EIDs) OT - Infection risk OT - Nucleic acid tests (NAT) EDAT- 2013/07/01 00:00 MHDA- 2013/07/01 00:01 PMCR- 2013/07/19 CRDT- 2020/04/01 06:00 PHST- 2013/05/31 00:00 [received] PHST- 2013/07/02 00:00 [accepted] PHST- 2020/04/01 06:00 [entrez] PHST- 2013/07/01 00:00 [pubmed] PHST- 2013/07/01 00:01 [medline] PHST- 2013/07/19 00:00 [pmc-release] AID - S0001-5814(13)00091-1 [pii] AID - 10.1016/j.achaem.2013.07.022 [doi] PST - ppublish SO - Acta Haematol Pol. 2013 Jul-Sep;44(3):284-293. doi: 10.1016/j.achaem.2013.07.022. Epub 2013 Jul 19. PMID- 20187867 OWN - NLM STAT- MEDLINE DCOM- 20100518 LR - 20220419 IS - 1744-8360 (Electronic) IS - 1473-7175 (Linking) VI - 10 IP - 3 DP - 2010 Mar TI - Radiofrequency treatment in chronic pain. PG - 469-74 LID - 10.1586/ern.09.153 [doi] AB - Chronic pain management physicians and patients are always looking for long-term solutions rather than short-lived interventions. There are three main nonsurgical modalities to ablate nervous system elements. These involve the use of extreme cold (cryoablation), high temperature radiofrequency and chemical neurolysis, such as alcohol or phenol. Radiofrequency ablation offers the advantage of being precise, reproducible and effective to a great extent. It also has the ability to stimulate before the ablation to avoid ablating the wrong nerve elements, which provides a considerable safety margin. In this article we will review the basis of radiofrequency ablation and some of the most common applications in the management of chronic pain. FAU - Soloman, Marc AU - Soloman M AD - Department of Pain Management, Cleveland Clinic, 9500 Euclid Ave (C25), Cleveland, OH 44195, USA. solimam@ccf.org FAU - Mekhail, Mark N AU - Mekhail MN FAU - Mekhail, Nagy AU - Mekhail N LA - eng PT - Journal Article PT - Review PL - England TA - Expert Rev Neurother JT - Expert review of neurotherapeutics JID - 101129944 SB - IM MH - Animals MH - Catheter Ablation/*methods MH - Chronic Disease MH - Cryosurgery/*methods MH - Humans MH - Pain/diagnosis MH - *Pain Management MH - Randomized Controlled Trials as Topic RF - 54 EDAT- 2010/03/02 06:00 MHDA- 2010/05/19 06:00 CRDT- 2010/03/02 06:00 PHST- 2010/03/02 06:00 [entrez] PHST- 2010/03/02 06:00 [pubmed] PHST- 2010/05/19 06:00 [medline] AID - 10.1586/ern.09.153 [doi] PST - ppublish SO - Expert Rev Neurother. 2010 Mar;10(3):469-74. doi: 10.1586/ern.09.153. PMID- 18984441 OWN - NLM STAT- MEDLINE DCOM- 20090219 LR - 20081105 IS - 1532-8511 (Electronic) IS - 1052-3057 (Linking) VI - 17 IP - 6 DP - 2008 Nov-Dec TI - Successful delayed thrombolysis for cerebral venous and dural sinus thrombosis: a case report and review of the literature. PG - 429-32 LID - 10.1016/j.jstrokecerebrovasdis.2008.07.001 [doi] AB - Cerebral venous and dural sinus thrombosis (CVDST) is a rare but not uncommon life-threatening disease accounting for less than 1% of stroke, affecting people of any age group, predominantly the extremes of age. CVDST carries a variable prognosis: although the majority of cases are associated with complete recovery, outcome may be fatal in less than 10% of patients. Thrombolysis has been widely used in CVDST in patients with rapidly deteriorating symptoms who fail to improve despite adequate anticoagulation, but the exact therapeutic time window remains unclear. We report a case of CVDST with rapid clinical deterioration despite therapeutic anticoagulation treated with direct endovascular thrombolysis with intravenous recombinant tissue plasminogen activator 1 week after presentation with complete recovery, and we present a review of the literature on the efficacy and safety of thrombolysis in CVDST. FAU - Hocker, Sara E AU - Hocker SE AD - Department of Neurology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA. FAU - Dafer, Rima M AU - Dafer RM FAU - Hacein-Bey, Lotfi AU - Hacein-Bey L LA - eng PT - Case Reports PT - Journal Article PL - United States TA - J Stroke Cerebrovasc Dis JT - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JID - 9111633 RN - 0 (Anticoagulants) RN - 0 (Fibrinolytic Agents) RN - 9005-49-6 (Heparin) RN - EC 3.4.21.68 (Tissue Plasminogen Activator) SB - IM MH - Adult MH - Anticoagulants/administration & dosage MH - Cerebral Angiography MH - Cerebral Veins/*drug effects/physiopathology MH - Coma/etiology/physiopathology MH - Disease Progression MH - Female MH - Fibrinolytic Agents/administration & dosage MH - Heparin/administration & dosage MH - Humans MH - Injections, Intravenous MH - Recovery of Function/drug effects/physiology MH - Sinus Thrombosis, Intracranial/*drug therapy/physiopathology MH - Thrombolytic Therapy/methods/*standards MH - Tissue Plasminogen Activator/*administration & dosage MH - Tomography, X-Ray Computed MH - Treatment Outcome MH - Vascular Surgical Procedures MH - Venous Thrombosis/*drug therapy/physiopathology EDAT- 2008/11/06 09:00 MHDA- 2009/02/20 09:00 CRDT- 2008/11/06 09:00 PHST- 2007/10/30 00:00 [received] PHST- 2008/05/30 00:00 [accepted] PHST- 2008/11/06 09:00 [pubmed] PHST- 2009/02/20 09:00 [medline] PHST- 2008/11/06 09:00 [entrez] AID - S1052-3057(08)00116-X [pii] AID - 10.1016/j.jstrokecerebrovasdis.2008.07.001 [doi] PST - ppublish SO - J Stroke Cerebrovasc Dis. 2008 Nov-Dec;17(6):429-32. doi: 10.1016/j.jstrokecerebrovasdis.2008.07.001. PMID- 33128738 OWN - NLM STAT- MEDLINE DCOM- 20210323 LR - 20210323 IS - 1940-6029 (Electronic) IS - 1064-3745 (Linking) VI - 2178 DP - 2021 TI - Protein Purification Technologies. PG - 3-10 LID - 10.1007/978-1-0716-0775-6_1 [doi] AB - Protein Biotechnology is an exciting and fast- growing area of research, with numerous industrial applications. The growing demand for developing efficient and rapid protein purification methods is driving research and growth in this area. Advances and progress in the techniques and methods of protein purification have been such that one can reasonably expect that any protein of a given order of stability may be purified to currently acceptable standards of homogeneity. However, protein manufacturing cost remains extremely high, with downstream processing constituting a substantial proportion of the overall cost. Understanding of the methods and optimization of the experimental conditions have become critical to the manufacturing industry in order to minimize production costs while satisfying the quality as well as all regulatory requirements. New purification processes exploiting specific, effective and robust methods and chromatographic materials are expected to guide the future of the protein purification market. FAU - Labrou, Nikolaos E AU - Labrou NE AD - Laboratory of Enzyme Technology, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, Athens, Greece. lambrou@aua.gr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Methods Mol Biol JT - Methods in molecular biology (Clifton, N.J.) JID - 9214969 RN - 0 (Proteins) SB - IM MH - Animals MH - Biotechnology/methods MH - Chemical Fractionation/methods MH - Chemical Precipitation MH - Chromatography/methods MH - Humans MH - Proteins/*isolation & purification OTO - NOTNLM OT - Chromatography OT - Downstream processing OT - Protein manufacturing OT - Protein purification OT - quality and safety EDAT- 2020/11/01 06:00 MHDA- 2021/03/24 06:00 CRDT- 2020/10/31 17:08 PHST- 2020/10/31 17:08 [entrez] PHST- 2020/11/01 06:00 [pubmed] PHST- 2021/03/24 06:00 [medline] AID - 10.1007/978-1-0716-0775-6_1 [doi] PST - ppublish SO - Methods Mol Biol. 2021;2178:3-10. doi: 10.1007/978-1-0716-0775-6_1. PMID- 21827293 OWN - NLM STAT- MEDLINE DCOM- 20120720 LR - 20220409 IS - 1745-7319 (Electronic) IS - 1745-7300 (Linking) VI - 19 IP - 1 DP - 2012 TI - A qualitative approach to the intangible cost of road traffic injuries. PG - 69-79 LID - 10.1080/17457300.2011.603155 [doi] AB - The consequences of fatal and non-fatal road traffic injuries (RTI) at the personal and household levels were analysed using qualitative interviews of 12 injured and of 12 relatives of people who died for this reason. Collisions change physical and mental health both of the injured and of their relatives. This leads to changes in daily activities and even to the redefinition of future life. RTI also changes the way people see and act in life, becoming an experience that teaches them. Survivors commonly transmit a road safety message afterwards. Changes in family life were evident (in extreme cases family's composition also changed), affecting intra-familial relationships. Associated unexpected and unplanned expenditures and loss of income have consequences in the short, medium and long term that unbalance household's economies and immerse people into a constant stress. Individuals and family's future plans are occasionally condition to whether they have or not debts. Household dependence in economic terms was sometimes observed, as well as uncertainty about future life and household's sustainability. Sometimes, households change and adapt their life to what they now are able to afford, having important repercussions in vital spheres. FAU - Pérez-Núñez, Ricardo AU - Pérez-Núñez R AD - Centro de Investigación en Sistemas de Salud del Instituto Nacional de Salud Pública, Cuernavaca, Morelos, México. FAU - Pelcastre-Villafuerte, Blanca AU - Pelcastre-Villafuerte B FAU - Híjar, Martha AU - Híjar M FAU - Avila-Burgos, Leticia AU - Avila-Burgos L FAU - Celis, Alfredo AU - Celis A LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110809 PL - England TA - Int J Inj Contr Saf Promot JT - International journal of injury control and safety promotion JID - 101247254 SB - IM MH - Accidents, Traffic/economics/*psychology MH - *Cost of Illness MH - Family Relations MH - Humans MH - Income MH - Interviews as Topic MH - *Life Change Events MH - Qualitative Research MH - Quality of Life/*psychology MH - Stress, Psychological/etiology MH - Survivors/psychology MH - Wounds and Injuries/economics/psychology EDAT- 2011/08/11 06:00 MHDA- 2012/07/21 06:00 CRDT- 2011/08/11 06:00 PHST- 2011/08/11 06:00 [entrez] PHST- 2011/08/11 06:00 [pubmed] PHST- 2012/07/21 06:00 [medline] AID - 10.1080/17457300.2011.603155 [doi] PST - ppublish SO - Int J Inj Contr Saf Promot. 2012;19(1):69-79. doi: 10.1080/17457300.2011.603155. Epub 2011 Aug 9. PMID- 32928399 OWN - NLM STAT- MEDLINE DCOM- 20210430 LR - 20210430 IS - 1873-3573 (Electronic) IS - 0039-9140 (Linking) VI - 220 DP - 2020 Dec 1 TI - Polyelectrolyte-functionalized reduced graphene oxide wrapped helical POMOF nanocomposites for bioenzyme-free colorimetric biosensing. PG - 121373 LID - S0039-9140(20)30664-0 [pii] LID - 10.1016/j.talanta.2020.121373 [doi] AB - For the sake of effective colorimetric sensing-pattern, a sensitive colorimetric sensor was conceived based on polyoxometalates based metal-organic frameworks (POMOFs) and polydiallyldimethylammonium chloride functionalized reduced graphene oxide (PDDA-rGO) for the first time, in which PDDA as a "glue" molecule turns rGO nanosheets into general platforms for bonding POMOFs nanoparticles. Herein, a new POMOF compound with fascinating helices-on-helices feature, [Ni(4)(Trz)(6)(H(2)O)(2)][SiW(12)O(40)](.)4H(2)O (Trz = 1,2,4-triazole) (abbreviated as Ni(4)SiW(12)), was synthesized and characterized, then PDDA-rGO sheet as dispersive and conductive material was successfully introduced to Ni(4)SiW(12) fabricating new PDDA-rGO/Ni(4)SiW(12)-n nanocomposites, (abbreviated as PMPG-n). The resulting PMPG-n nanocomposites as peroxidase mimetic show excellent catalytic activities under extreme condition (pH value 2.5), attributed to the nature and synergies from POMs, MOFs and PDDA-rGOs. Note that the peroxidase-like activity of PMPG-1 (the mass ratio of Ni(4)SiW(12) to PDDA-rGO is 1:1) exhibits higher sensitivity (1-60 μM), faster response (10 min) and the lowest limit of detection (2.07 μM) among all reported materials to citric acid (CA) to date. This work opens up new application prospects in colorimetric sensing system for food quality control and safety, biotechnology and clinical diagnosis. CI - Copyright © 2020 Elsevier B.V. All rights reserved. FAU - Tong, Zhibo AU - Tong Z AD - Department of Chemistry and Chemical Engineering, Jining University, ShanDong, Qufu, 273155, PR China; School of Pharmacy, Jiamusi University, HeilongJiang, Jiamusi, 154007, PR China. FAU - Xu, Mingqi AU - Xu M AD - Department of Chemistry and Chemical Engineering, Jining University, ShanDong, Qufu, 273155, PR China. FAU - Li, Qian AU - Li Q AD - Department of Chemistry and Chemical Engineering, Jining University, ShanDong, Qufu, 273155, PR China. FAU - Liu, Chang AU - Liu C AD - Department of Chemistry and Chemical Engineering, Jining University, ShanDong, Qufu, 273155, PR China. FAU - Wang, Yunliang AU - Wang Y AD - School of Pharmacy, Jiamusi University, HeilongJiang, Jiamusi, 154007, PR China. FAU - Sha, Jingquan AU - Sha J AD - Department of Chemistry and Chemical Engineering, Jining University, ShanDong, Qufu, 273155, PR China. Electronic address: shajq2002@126.com. LA - eng PT - Journal Article DEP - 20200711 PL - Netherlands TA - Talanta JT - Talanta JID - 2984816R RN - 0 (Enzymes) RN - 0 (Polyelectrolytes) RN - 0 (graphene oxide) RN - 7782-42-5 (Graphite) SB - IM MH - Biosensing Techniques MH - *Colorimetry MH - Enzymes MH - *Graphite MH - *Nanocomposites MH - Polyelectrolytes OTO - NOTNLM OT - Citric acid OT - Colorimetric sensor OT - Helix OT - PDDA-rGO OT - POMOF EDAT- 2020/09/16 06:00 MHDA- 2021/05/01 06:00 CRDT- 2020/09/15 05:36 PHST- 2020/05/12 00:00 [received] PHST- 2020/06/29 00:00 [revised] PHST- 2020/07/02 00:00 [accepted] PHST- 2020/09/15 05:36 [entrez] PHST- 2020/09/16 06:00 [pubmed] PHST- 2021/05/01 06:00 [medline] AID - S0039-9140(20)30664-0 [pii] AID - 10.1016/j.talanta.2020.121373 [doi] PST - ppublish SO - Talanta. 2020 Dec 1;220:121373. doi: 10.1016/j.talanta.2020.121373. Epub 2020 Jul 11. PMID- 31517654 OWN - NLM STAT- MEDLINE DCOM- 20201030 LR - 20210206 IS - 1524-4725 (Electronic) IS - 1076-0512 (Linking) VI - 46 IP - 5 DP - 2020 May TI - ATX-101 (Deoxycholic Acid Injection) Leads to Clinically Meaningful Improvement in Submental Fat: Final Data From CONTOUR. PG - 639-645 LID - 10.1097/DSS.0000000000002092 [doi] AB - BACKGROUND: Submental fat (SMF) can negatively affect perceptions of health and attractiveness. The Condition of Submental Fullness and Treatment Outcomes Registry (CONTOUR) was designed to understand SMF treatment in clinical practice. OBJECTIVE: To report efficacy, treatment characteristics, and safety associated with real-world use of ATX-101 (deoxycholic acid injection). METHODS: CONTOUR enrolled adults considering treatment for SMF reduction. ATX-101-treated patients who completed the end-of-treatment questionnaire were divided into those who ended treatment because they met their treatment goals (n = 197) and those who did not (n = 196). RESULTS: Patients who met their goals (a more defined jawline, looking younger, and looking thinner) were more likely to have less SMF at baseline and to receive ≥2 ATX-101 treatments. More patients who met their goals achieved clinically meaningful reduction in SMF and reported increased satisfaction with their appearance (90% vs 57%). Moderate and severe patients' ATX-101 volume was similar for both those who met goals and those who did not, but extreme patients who met their goals required 10 mL more than those patients who did not. CONCLUSION: Careful patient selection, adequate volume administration, and an appropriate number of treatments (dependent on baseline SMF severity) contribute to successful outcomes with ATX-101. FAU - Behr, Kathleen AU - Behr K AD - Private Practice (Behr Laser & Skin Care Center), Fresno, California. FAU - Kavali, Carmen M AU - Kavali CM AD - Private Practice (Kavali Plastic Surgery and Skin Renewal Center), Atlanta, Georgia. FAU - Munavalli, Girish AU - Munavalli G AD - Private Practice (Dermatology, Laser & Vein Specialists of the Carolinas), Charlotte, North Carolina. FAU - Teller, Craig F AU - Teller CF AD - Private Practice (Bellaire Dermatology Associates), Bellaire, Texas. FAU - Yoelin, Steve AU - Yoelin S AD - Private Practice (Medical Associates, Inc.), Newport Beach, California. FAU - Breshears, Laura AU - Breshears L AD - Evidence Scientific Solutions, Philadelphia, Pennsylvania. FAU - Sangha, Sara AU - Sangha S AD - Medical Affairs, Allergan plc, Irvine, California. LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - Dermatol Surg JT - Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] JID - 9504371 RN - 005990WHZZ (Deoxycholic Acid) SB - IM MH - Canada MH - *Chin MH - *Cosmetic Techniques MH - Deoxycholic Acid/*administration & dosage MH - Female MH - Humans MH - Injections, Subcutaneous MH - Male MH - Middle Aged MH - Patient Satisfaction MH - Patient Selection MH - Prospective Studies MH - Registries MH - Subcutaneous Fat/*drug effects MH - United States EDAT- 2019/09/14 06:00 MHDA- 2020/10/31 06:00 CRDT- 2019/09/14 06:00 PHST- 2019/09/14 06:00 [pubmed] PHST- 2020/10/31 06:00 [medline] PHST- 2019/09/14 06:00 [entrez] AID - 00042728-202005000-00011 [pii] AID - 10.1097/DSS.0000000000002092 [doi] PST - ppublish SO - Dermatol Surg. 2020 May;46(5):639-645. doi: 10.1097/DSS.0000000000002092. PMID- 32484323 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200707 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 12 IP - 26 DP - 2020 Jul 1 TI - Aqueous-Eutectic-in-Salt Electrolytes for High-Energy-Density Supercapacitors with an Operational Temperature Window of 100 °C, from -35 to +65 °C. PG - 29181-29193 LID - 10.1021/acsami.0c04011 [doi] AB - Water-in-salt (WIS) electrolytes are gaining increased interest as an alternative to conventional aqueous or organic ones. WIS electrolytes offer an interesting combination of safety, thanks to their aqueous character, and extended electrochemical stability window, thanks to the strong coordination between water molecules and ion salt. Nonetheless, cost, the tendency of salt precipitation, and sluggish ionic transfer leading to poor rate performance of devices are some intrinsic drawbacks of WIS electrolytes that yet need to be addressed for their technological implementation. It is worth noting that the absence of "free'' water molecules could also be achieved via the addition of a certain cosolvent capable of coordinating with water. This is the case of the eutectic mixture formed between DMSO and H(2)O with a molar ratio of 1:2 and a melting point as low as -140 °C. Interestingly, addition of salts at near-saturation conditions also resulted in an increase of the boiling point of the resulting solution. Herein, we used a eutectic mixture of DMSO and H(2)O for dissolution of LiTFSI in the 1.1-8.8 molality range. The resulting electrolyte (e.g., the so-called aqueous-eutectic-in-salt) exhibited excellent energy and power densities when operating in a supercapacitor cell over a wide range of extreme ambient temperatures, from as low as -35 °C to as high as +65 °C. FAU - Lu, Xuejun AU - Lu X AD - Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientı́ficas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. FAU - Jiménez-Riobóo, Rafael J AU - Jiménez-Riobóo RJ AD - Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientı́ficas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. FAU - Leech, Donal AU - Leech D AUID- ORCID: 0000-0001-7844-1306 AD - School of Chemistry, National University of Ireland Galway, University Road, H91 TK33 Galway, Ireland. FAU - Gutiérrez, María C AU - Gutiérrez MC AUID- ORCID: 0000-0001-8612-7974 AD - Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientı́ficas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. FAU - Ferrer, M Luisa AU - Ferrer ML AUID- ORCID: 0000-0003-2284-8259 AD - Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientı́ficas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. FAU - Del Monte, Francisco AU - Del Monte F AUID- ORCID: 0000-0002-2868-0023 AD - Materials Science Factory, Instituto de Ciencia de Materiales de Madrid (ICMM), Consejo Superior de Investigaciones Cientı́ficas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain. LA - eng PT - Journal Article DEP - 20200618 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - Brillouin spectroscopy OT - NMR spectroscopy OT - Raman spectroscopy OT - aqueous-eutectic-in-salt electrolytes OT - extreme ambient temperatures OT - solvent-in-salt electrolytes OT - supercapacitors OT - water-in-salt electrolytes EDAT- 2020/06/03 06:00 MHDA- 2020/06/03 06:01 CRDT- 2020/06/03 06:00 PHST- 2020/06/03 06:00 [pubmed] PHST- 2020/06/03 06:01 [medline] PHST- 2020/06/03 06:00 [entrez] AID - 10.1021/acsami.0c04011 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2020 Jul 1;12(26):29181-29193. doi: 10.1021/acsami.0c04011. Epub 2020 Jun 18. PMID- 38182875 OWN - NLM STAT- MEDLINE DCOM- 20240108 LR - 20240202 IS - 2399-3642 (Electronic) IS - 2399-3642 (Linking) VI - 7 IP - 1 DP - 2024 Jan 5 TI - Attachment performance of the ectoparasitic seal louse Echinophthirius horridus. PG - 36 LID - 10.1038/s42003-023-05722-0 [doi] LID - 36 AB - Marine mammals host a great variety of parasites, which usually co-evolved in evolutionary arms races. However, little is known about the biology of marine mammal insect parasites, and even less about physical aspects of their life in such a challenging environment. One of 13 insect species that manage to endure long diving periods in the open sea is the seal louse, Echinophthirius horridus, parasitising true seals. Its survival depends on its specialised adaptations for enduring extreme conditions such as hypoxia, temperature changes, hydrostatic pressure, and strong drag forces during host dives. To maintain a grip on the seal fur, the louse's leg morphology is equipped with modified snap hook claws and soft pad-like structures that enhance friction. Through techniques including CLSM, SEM, and histological staining, we have examined the attachment system's detailed structure. Remarkably, the seal louse achieves exceptional attachment forces on seal fur, with safety factors (force per body weight) reaching 4500 in average measurements and up to 18000 in peak values, indicating superior attachment performance compared to other insect attachment systems. These findings underscore the louse's remarkable adaptations for life in a challenging marine environment, shedding light on the relationship between structure and function in extreme ecological niches. CI - © 2024. The Author(s). FAU - Preuss, Anika AU - Preuss A AUID- ORCID: 0000-0003-0811-1613 AD - Department of Functional Morphology and Biomechanics, Zoological Institute, Kiel University, Kiel, Germany. apreuss@zoologie.uni-kiel.de. FAU - Büscher, Thies H AU - Büscher TH AUID- ORCID: 0000-0003-0639-4699 AD - Department of Functional Morphology and Biomechanics, Zoological Institute, Kiel University, Kiel, Germany. FAU - Herzog, Insa AU - Herzog I AUID- ORCID: 0000-0003-0534-0461 AD - Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Büsum, Germany. FAU - Wohlsein, Peter AU - Wohlsein P AD - Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany. FAU - Lehnert, Kristina AU - Lehnert K AD - Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, Büsum, Germany. FAU - Gorb, Stanislav N AU - Gorb SN AUID- ORCID: 0000-0001-9712-7953 AD - Department of Functional Morphology and Biomechanics, Zoological Institute, Kiel University, Kiel, Germany. LA - eng GR - GO 995 46-1/Deutsche Forschungsgemeinschaft (German Research Foundation)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240105 PL - England TA - Commun Biol JT - Communications biology JID - 101719179 SB - IM MH - Animals MH - *Phthiraptera MH - *Seals, Earless MH - Biological Evolution MH - Body Weight MH - *Diving PMC - PMC10770372 COIS- All authors declare no competing interests. EDAT- 2024/01/06 10:42 MHDA- 2024/01/08 06:42 PMCR- 2024/01/05 CRDT- 2024/01/05 23:38 PHST- 2023/09/13 00:00 [received] PHST- 2023/12/18 00:00 [accepted] PHST- 2024/01/08 06:42 [medline] PHST- 2024/01/06 10:42 [pubmed] PHST- 2024/01/05 23:38 [entrez] PHST- 2024/01/05 00:00 [pmc-release] AID - 10.1038/s42003-023-05722-0 [pii] AID - 5722 [pii] AID - 10.1038/s42003-023-05722-0 [doi] PST - epublish SO - Commun Biol. 2024 Jan 5;7(1):36. doi: 10.1038/s42003-023-05722-0. PMID- 39857873 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250130 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 1 DP - 2024 Dec 30 TI - L-Citrulline in Neonates: From Bench to Bed Side. LID - 10.3390/children12010042 [doi] LID - 42 AB - L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). This review summarizes the current evidence around the possible role of L-CIT supplementation in the treatment of these conditions. Detoxification of endogenously produced superoxide radicals is inadequate in preterm infants due to immature antioxidants that leads to the production of peroxynitrite, a reactive oxygen-free radical that is cytotoxic and causes damage to organelles and cellular membranes, further disrupting the coupling of endothelial NO synthase enzyme and the generation of high levels of reactive nitrogen and oxygen species. Animal studies in lipopolysaccharide-induced models of chorioamnionitis and hyperoxia- and inflammation-induced BPD-PH in rodent lung models revealed that L-CIT supplementation significantly mitigated structural changes in the pulmonary vasculature, preserved alveolar growth, and increased vascular endothelial growth factor gene expression, highlighting the anti-inflammatory and antioxidant effects of L-CIT supplementation. Similar benefits were noted in newborn piglet models of chronic hypoxia-induced PH and NEC. Pharmacokinetic studies in neonates have shown doses of 100-300 mg/kg/day to be safe and well tolerated. A few studies have shown the beneficial effects of L-CIT supplementation in pulmonary hypertension secondary to congenital heart disease, but evidence of efficacy in the neonatal population is lacking. While L-CIT shows promise in the treatment of various neonatal conditions, adequately powered studies to evaluate the safety and efficacy of L-CIT supplementation post-surgical NEC and BPD ± PH in the extremely preterm population are needed to translate this novel therapy to clinical practice. FAU - Mascarenhas, Dwayne AU - Mascarenhas D AD - Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. FAU - Mohammadi, Atefeh AU - Mohammadi A AUID- ORCID: 0009-0008-4781-8834 AD - Translational Medicine and Cell Biology Programs, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada. AD - Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3K3, Canada. FAU - Higazy, Randa AU - Higazy R AD - Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3K3, Canada. FAU - Ivanovska, Julijana AU - Ivanovska J AD - Translational Medicine and Cell Biology Programs, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada. FAU - Gauda, Estelle AU - Gauda E AD - Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. AD - Translational Medicine and Cell Biology Programs, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 1E8, Canada. AD - Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 3K3, Canada. FAU - Jasani, Bonny AU - Jasani B AD - Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. LA - eng PT - Journal Article PT - Review DEP - 20241230 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC11763423 OTO - NOTNLM OT - L-arginine OT - L-citrulline OT - bronchopulmonary dysplasia OT - necrotizing enterocolitis OT - nitric oxide OT - pulmonary hypertension COIS- The authors declare no conflict of interest. EDAT- 2025/01/25 13:54 MHDA- 2025/01/25 13:55 PMCR- 2024/12/30 CRDT- 2025/01/25 01:08 PHST- 2024/11/18 00:00 [received] PHST- 2024/12/16 00:00 [revised] PHST- 2024/12/23 00:00 [accepted] PHST- 2025/01/25 13:55 [medline] PHST- 2025/01/25 13:54 [pubmed] PHST- 2025/01/25 01:08 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - children12010042 [pii] AID - children-12-00042 [pii] AID - 10.3390/children12010042 [doi] PST - epublish SO - Children (Basel). 2024 Dec 30;12(1):42. doi: 10.3390/children12010042. PMID- 30770156 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20190823 IS - 1879-2022 (Electronic) IS - 0019-0578 (Linking) VI - 91 DP - 2019 Aug TI - A fault diagnosis scheme for rotating machinery using hierarchical symbolic analysis and convolutional neural network. PG - 235-252 LID - S0019-0578(19)30029-1 [pii] LID - 10.1016/j.isatra.2019.01.018 [doi] AB - Fault diagnosis of rotating machinery is crucial to improve safety, enhance reliability and reduce maintenance cost. The manual feature extraction and selection of traditional fault diagnosis methods depend on signal processing skills and expert experience, which is labor-intensive and time-consuming. As a typical intelligent fault diagnosis method, the convolutional neural network automatically learns features from original data, but it is extremely difficult to design and train a deep network architecture. This paper proposes a fault diagnosis scheme combined of hierarchical symbolic analysis (HSA) and convolutional neural network (CNN), which achieves laborsaving and timesaving preliminary feature extraction and accomplishes automatically feature learning with simplified network architecture. Firstly, hierarchical symbolic analysis is employed to extract features from original signals. The extracted features are able to identify different health conditions under various operating conditions. Then, convolutional neural network instead of human labor is used to learn the complex non-linear relationship between features and health conditions automatically. The architecture of CNN diagnosis model is simple and convenient to implement. Finally, a centrifugal pump dataset and a motor bearing dataset are adopted to validate the effectiveness of the proposed method. The diagnosis results show that the proposed method exhibits superior performance compared with shallow methods and deep learning methods. CI - Copyright © 2019 ISA. Published by Elsevier Ltd. All rights reserved. FAU - Yang, Yuantao AU - Yang Y AD - School of Astronautics, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. FAU - Zheng, Huailiang AU - Zheng H AD - School of Astronautics, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. FAU - Li, Yongbo AU - Li Y AD - School of Aeronautics, Northwestern Polytechnical University, Xi'an, Shanxi, 710072, China. FAU - Xu, Minqiang AU - Xu M AD - School of Astronautics, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. Electronic address: xumqhit@126.com. FAU - Chen, Yushu AU - Chen Y AD - School of Astronautics, Harbin Institute of Technology, Harbin, Heilongjiang, 150001, China. LA - eng PT - Journal Article DEP - 20190124 PL - United States TA - ISA Trans JT - ISA transactions JID - 0374750 SB - IM OTO - NOTNLM OT - Convolutional neural network OT - Fault diagnosis OT - Hierarchical symbolic analysis OT - Rotating machinery EDAT- 2019/02/17 06:00 MHDA- 2019/02/17 06:01 CRDT- 2019/02/17 06:00 PHST- 2018/07/31 00:00 [received] PHST- 2019/01/01 00:00 [revised] PHST- 2019/01/17 00:00 [accepted] PHST- 2019/02/17 06:00 [pubmed] PHST- 2019/02/17 06:01 [medline] PHST- 2019/02/17 06:00 [entrez] AID - S0019-0578(19)30029-1 [pii] AID - 10.1016/j.isatra.2019.01.018 [doi] PST - ppublish SO - ISA Trans. 2019 Aug;91:235-252. doi: 10.1016/j.isatra.2019.01.018. Epub 2019 Jan 24. PMID- 20160341 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100507 LR - 20100219 IS - 1361-6528 (Electronic) IS - 0957-4484 (Linking) VI - 21 IP - 10 DP - 2010 Mar 12 TI - Growth and morphology control of carbon nanotubes at the apexes of pyramidal silicon tips. PG - 105605 LID - 10.1088/0957-4484/21/10/105605 [doi] AB - We describe the development of catalysed chemical vapour deposition (cCVD) growth schemes suitable for the production of carbon nanotube atomic force microscopy (CNT-AFM) probes. Growth and sample processing conditions are utilized that both incorporate safety in the process, e.g. the use of ethanol (EtOH) vapour as a carbon feedstock and hydrogen at only 4% (flow proportion), and simplicity, e.g. no catalyst patterning is required. Cobalt is employed as the growth catalyst and thin films of aluminium on silicon as the substrate material. Purpose-fabricated silicon substrates containing large numbers of tip structures are used as models of AFM probes. This enables growth to be carried out on many tips at once, facilitating a thorough investigation of the effect of different growth schemes on yields. cCVD growth schemes are chosen which produce stabilizing high density networks of carbon nanotubes on the sidewalls of the pyramidal tips to aid in anchoring the apex protruding carbon nanotube(s) in place. This results in long-lasting AFM imaging tips. We demonstrate that through rational tailoring of cCVD conditions it is possible to tune the growth conditions such that CNTs which protrude straight from tip apexes can be obtained at yields of greater than or equal to 78%. Application of suitable growth schemes to CNT growth on commercially available AFM probes resulted in CNT-AFM probes which were found to be extremely useful for extended lifetime metrological profiling of complex structures. FAU - Edgeworth, J P AU - Edgeworth JP AD - Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. FAU - Burt, D P AU - Burt DP FAU - Dobson, P S AU - Dobson PS FAU - Weaver, J M R AU - Weaver JM FAU - Macpherson, J V AU - Macpherson JV LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20100216 PL - England TA - Nanotechnology JT - Nanotechnology JID - 101241272 EDAT- 2010/02/18 06:00 MHDA- 2010/02/18 06:01 CRDT- 2010/02/18 06:00 PHST- 2010/02/18 06:00 [entrez] PHST- 2010/02/18 06:00 [pubmed] PHST- 2010/02/18 06:01 [medline] AID - S0957-4484(10)34100-6 [pii] AID - 10.1088/0957-4484/21/10/105605 [doi] PST - ppublish SO - Nanotechnology. 2010 Mar 12;21(10):105605. doi: 10.1088/0957-4484/21/10/105605. Epub 2010 Feb 16. PMID- 35469449 OWN - NLM STAT- MEDLINE DCOM- 20220608 LR - 20220915 IS - 1744-8298 (Electronic) IS - 1479-6678 (Linking) VI - 18 IP - 6 DP - 2022 Jun TI - Lessons learned from the evinacumab trials in the treatment of homozygous familial hypercholesterolemia. PG - 507-518 LID - 10.2217/fca-2021-0149 [doi] AB - Homozygous familial hypercholesterolemia (HoFH) is a life-threatening disease characterized by extremely elevated LDL cholesterol (LDL-C) levels which result in premature atherosclerotic cardiovascular disease. As conventional lipid-lowering therapies, which mainly depend on LDL receptors for LDL particle clearance, remain insufficient for reaching the recommended LDL-C levels in HoFH, agents acting independently of LDL receptors, such as ANGPTL3 inhibitors, constitute a promising target. Evinacumab, a monoclonal antibody directed against ANGPTL3, was approved in the USA in 2021 for treating patients with HoFH. Evinacumab has shown an adequate safety profile with strong LDL-lowering efficacy. This review highlights the development path of evinacumab and provides insight on the lessons learned from trials as well as the hurdles facing accessibility. FAU - Khoury, Etienne AU - Khoury E AUID- ORCID: 0000-0003-2943-9175 AD - Department of Medicine, Clinical Lipidology & Rare Lipid Disorders Unit, Community Genomic Medicine Center, Université de Montréal & ECOGENE-21 Clinical & Translational Research Center, Chicoutimi, Québec, Canada. FAU - Croteau, Laurent AU - Croteau L AD - Department of Medicine, Clinical Lipidology & Rare Lipid Disorders Unit, Community Genomic Medicine Center, Université de Montréal & ECOGENE-21 Clinical & Translational Research Center, Chicoutimi, Québec, Canada. FAU - Lauzière, Alex AU - Lauzière A AD - Department of Medicine, Clinical Lipidology & Rare Lipid Disorders Unit, Community Genomic Medicine Center, Université de Montréal & ECOGENE-21 Clinical & Translational Research Center, Chicoutimi, Québec, Canada. AD - Lipid Clinic, Chicoutimi Hospital. FAU - Gaudet, Daniel AU - Gaudet D AD - Department of Medicine, Clinical Lipidology & Rare Lipid Disorders Unit, Community Genomic Medicine Center, Université de Montréal & ECOGENE-21 Clinical & Translational Research Center, Chicoutimi, Québec, Canada. AD - Lipid Clinic, Chicoutimi Hospital. LA - eng PT - Journal Article PT - Review DEP - 20220426 PL - England TA - Future Cardiol JT - Future cardiology JID - 101239345 RN - 0 (ANGPTL3 protein, human) RN - 0 (Angiopoietin-Like Protein 3) RN - 0 (Angiopoietin-like Proteins) RN - 0 (Antibodies, Monoclonal) RN - 0 (Anticholesteremic Agents) RN - 0 (Cholesterol, LDL) RN - 0 (Receptors, LDL) RN - T8B2ORP1DW (evinacumab) SB - IM MH - Angiopoietin-Like Protein 3 MH - Angiopoietin-like Proteins MH - Antibodies, Monoclonal/therapeutic use MH - *Anticholesteremic Agents/therapeutic use MH - Cholesterol, LDL MH - *Homozygous Familial Hypercholesterolemia MH - Humans MH - Receptors, LDL OAB - Homozygous familial hypercholesterolemia (HoFH) is a life-threatening rare genetic disorder characterized by extremely elevated ‘bad’ cholesterol and resulting in heart disease at a young age. As the current treatments that tend to lower the levels of ‘bad’ cholesterol remain insufficient for treating patients with this disease, emerging agents, such as inhibitors of the protein ANGPTL3, follow different biological pathways than the ones targeted by the traditional therapies and constitute a promising target for HoFH. Evinacumab, which is highly selective for ANGPTL3 inhibition, was approved in the USA in 2021 for treating patients with HoFH. Evinacumab has been shown to be safe and well tolerated, with a strong effect on decreasing ‘bad’ cholesterol levels. This review highlights the development path of evinacumab and provides insight into the lessons learned from trials as well as the hurdles facing accessibility. OABL- eng OTO - NOTNLM OT - ANGPTL3 inhibition OT - cardiovascular disease OT - clinical trials OT - evinacumab OT - homozygous familial hypercholesterolemia OT - rare lipid disorders OT - safety and efficacy EDAT- 2022/04/27 06:00 MHDA- 2022/06/09 06:00 CRDT- 2022/04/26 05:53 PHST- 2022/04/27 06:00 [pubmed] PHST- 2022/06/09 06:00 [medline] PHST- 2022/04/26 05:53 [entrez] AID - 10.2217/fca-2021-0149 [doi] PST - ppublish SO - Future Cardiol. 2022 Jun;18(6):507-518. doi: 10.2217/fca-2021-0149. Epub 2022 Apr 26. PMID- 19641201 OWN - NLM STAT- MEDLINE DCOM- 20090806 LR - 20220330 IS - 1533-4406 (Electronic) IS - 0028-4793 (Print) IS - 0028-4793 (Linking) VI - 361 IP - 5 DP - 2009 Jul 30 TI - Perioperative safety in the longitudinal assessment of bariatric surgery. PG - 445-54 LID - 10.1056/NEJMoa0901836 [doi] AB - BACKGROUND: To improve decision making in the treatment of extreme obesity, the risks of bariatric surgical procedures require further characterization. METHODS: We performed a prospective, multicenter, observational study of 30-day outcomes in consecutive patients undergoing bariatric surgical procedures at 10 clinical sites in the United States from 2005 through 2007. A composite end point of 30-day major adverse outcomes (including death; venous thromboembolism; percutaneous, endoscopic, or operative reintervention; and failure to be discharged from the hospital) was evaluated among patients undergoing first-time bariatric surgery. RESULTS: There were 4776 patients who had a first-time bariatric procedure (mean age, 44.5 years; 21.1% men; 10.9% nonwhite; median body-mass index [the weight in kilograms divided by the square of the height in meters], 46.5). More than half had at least two coexisting conditions. A Roux-en-Y gastric bypass was performed in 3412 patients (with 87.2% of the procedures performed laparoscopically), and laparoscopic adjustable gastric banding was performed in 1198 patients; 166 patients underwent other procedures and were not included in the analysis. The 30-day rate of death among patients who underwent a Roux-en-Y gastric bypass or laparoscopic adjustable gastric banding was 0.3%; a total of 4.3% of patients had at least one major adverse outcome. A history of deep-vein thrombosis or pulmonary embolus, a diagnosis of obstructive sleep apnea, and impaired functional status were each independently associated with an increased risk of the composite end point. Extreme values of body-mass index were significantly associated with an increased risk of the composite end point, whereas age, sex, race, ethnic group, and other coexisting conditions were not. CONCLUSIONS: The overall risk of death and other adverse outcomes after bariatric surgery was low and varied considerably according to patient characteristics. In helping patients make appropriate choices, short-term safety should be considered in conjunction with both the long-term effects of bariatric surgery and the risks associated with being extremely obese. (ClinicalTrials.gov number, NCT00433810.) CI - 2009 Massachusetts Medical Society CN - Longitudinal Assessment of Bariatric Surgery (LABS) Consortium FAU - Flum, David Reed AU - Flum DR FAU - Belle, Steven H AU - Belle SH FAU - King, Wendy C AU - King WC FAU - Wahed, Abdus S AU - Wahed AS FAU - Berk, Paul AU - Berk P FAU - Chapman, William AU - Chapman W FAU - Pories, Walter AU - Pories W FAU - Courcoulas, Anita AU - Courcoulas A FAU - McCloskey, Carol AU - McCloskey C FAU - Mitchell, James AU - Mitchell J FAU - Patterson, Emma AU - Patterson E FAU - Pomp, Alfons AU - Pomp A FAU - Staten, Myrlene A AU - Staten MA FAU - Yanovski, Susan Z AU - Yanovski SZ FAU - Thirlby, Richard AU - Thirlby R FAU - Wolfe, Bruce AU - Wolfe B LA - eng SI - ClinicalTrials.gov/NCT00433810 GR - U01 DK066585-05/DK/NIDDK NIH HHS/United States GR - U01 DK066555/DK/NIDDK NIH HHS/United States GR - U01-DK66526/DK/NIDDK NIH HHS/United States GR - M01RR-00037/RR/NCRR NIH HHS/United States GR - U01 DK066526/DK/NIDDK NIH HHS/United States GR - U01 DK066557-05/DK/NIDDK NIH HHS/United States GR - U01 DK066555-05/DK/NIDDK NIH HHS/United States GR - U01 DK066471-05/DK/NIDDK NIH HHS/United States GR - U01-DK66568/DK/NIDDK NIH HHS/United States GR - U01 DK066471/DK/NIDDK NIH HHS/United States GR - UL1 TR000005/TR/NCATS NIH HHS/United States GR - U01 DK066568-05/DK/NIDDK NIH HHS/United States GR - U01 DK066526-05/DK/NIDDK NIH HHS/United States GR - U01 DK066585/DK/NIDDK NIH HHS/United States GR - U01 DK066557/DK/NIDDK NIH HHS/United States GR - U01 DK066568/DK/NIDDK NIH HHS/United States GR - M01 RR000037/RR/NCRR NIH HHS/United States GR - U01-DK066557/DK/NIDDK NIH HHS/United States GR - U01-DK66471/DK/NIDDK NIH HHS/United States GR - U01-DK66585/DK/NIDDK NIH HHS/United States GR - U01-DK66667/DK/NIDDK NIH HHS/United States GR - U01 DK066667-05/DK/NIDDK NIH HHS/United States GR - U01-DK66555/DK/NIDDK NIH HHS/United States GR - U01 DK066667/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural PL - United States TA - N Engl J Med JT - The New England journal of medicine JID - 0255562 SB - IM CIN - N Engl J Med. 2009 Jul 30;361(5):520-1. doi: 10.1056/NEJMe0904837. PMID: 19641209 CIN - N Engl J Med. 2009 Nov 5;361(19):1910; author reply 1911. doi: 10.1056/NEJMc091728. PMID: 19890138 CIN - N Engl J Med. 2009 Nov 5;361(19):1911; author reply 1911. PMID: 19911438 MH - Adult MH - Aged MH - Bariatric Surgery/methods/*mortality MH - Body Mass Index MH - Comorbidity MH - Female MH - Humans MH - Length of Stay MH - Male MH - Middle Aged MH - Obesity/complications/*surgery MH - Observation MH - Outcome Assessment, Health Care MH - Postoperative Complications/*epidemiology/mortality MH - Prospective Studies MH - Reoperation/statistics & numerical data MH - Risk Factors MH - Sleep Apnea, Obstructive/complications MH - Thromboembolism/epidemiology MH - Venous Thrombosis/epidemiology PMC - PMC2854565 MID - NIHMS166855 COIS- Disclosure: Dr. Chapman reports receiving grant support from Covidien and has served as an expert witness on legal cases involving MIS and bariatric surgery. Dr. Courcoulas reports receiving grant support from Allergan, Covidien, and Pfizer. Dr. Flum reports receiving grant support from Sanofi-Aventis and Covidien and has served as an expert witness on cases involving adverse events after bariatric surgery. Dr. McCloskey reports receiving grant support from Stryker. Dr. Mitchell reports receiving grant support from GlaxoSmithKline, Lilly Research and Pfizer. Dr. Patterson reports receiving consulting fees from Allergan Health; lecture fees from Allergan Health and Legacy Health; grant support from Allergan Health and Legacy Health; Dr. Patterson also served as an expert witness in a case involving adverse events after bariatric surgery. Dr. Pomp reports receiving consulting fees from Covidien, W.L. Gore & Associates and Ethicon EndoSurgery; lecture fees from Covidien and W.L. Gore & Associates; grant support from Covidien and Ethicon EndoSurgery; he has also served as an expert witness for legal cases involving bariatric and other laparoscopic procedures. Dr. Pories reports receiving consulting fees and grant support from Johnson & Johnson, and lecture fees from Tyco. Dr. Wolfe reports receiving grant support from EnteroMedics and consulting fees from Johnson & Johnson. Dr. Yanovski reports that her spouse has received grant support from Obecure. No other potential conflicts of interest relevant to this article were reported. FIR - Berk, P D IR - Berk PD FIR - Bessler, M IR - Bessler M FIR - Daud, A IR - Daud A FIR - Davis, D IR - Davis D FIR - Inabnet, W B IR - Inabnet WB FIR - Kassam, M IR - Kassam M FIR - Schrope, B IR - Schrope B FIR - Dakin, G IR - Dakin G FIR - Ebel, F IR - Ebel F FIR - Gagner, M IR - Gagner M FIR - Hsieh, J IR - Hsieh J FIR - Pomp, A IR - Pomp A FIR - Strain, G IR - Strain G FIR - Bowden, R IR - Bowden R FIR - Chapman, W IR - Chapman W FIR - Dohm, L IR - Dohm L FIR - Pender, J IR - Pender J FIR - Pories, W IR - Pories W FIR - Howell, M IR - Howell M FIR - Garcia, L IR - Garcia L FIR - Kuznia, M IR - Kuznia M FIR - Lancaster, K IR - Lancaster K FIR - Mitchell, J E IR - Mitchell JE FIR - Monson, T IR - Monson T FIR - Roth, J IR - Roth J FIR - Deveney, C IR - Deveney C FIR - Elder, K IR - Elder K FIR - Green, S IR - Green S FIR - Lee, R IR - Lee R FIR - Purnell, J IR - Purnell J FIR - O'Rourke, R IR - O'Rourke R FIR - Sorenson, C IR - Sorenson C FIR - Wolfe, B M IR - Wolfe BM FIR - Walker, Z IR - Walker Z FIR - Halpin, V IR - Halpin V FIR - Jan, J IR - Jan J FIR - Jones, C IR - Jones C FIR - Patterson, E IR - Patterson E FIR - Petrovic, M IR - Petrovic M FIR - Rogers, C IR - Rogers C FIR - Austrheim-Smith, I IR - Austrheim-Smith I FIR - Machado, L IR - Machado L FIR - Courcoulas, A P IR - Courcoulas AP FIR - Eid, G IR - Eid G FIR - Gourash, W IR - Gourash W FIR - Kuller, L H IR - Kuller LH FIR - Marcus, M IR - Marcus M FIR - McCloskey, C A IR - McCloskey CA FIR - Ramanathan, R IR - Ramanathan R FIR - Elrod, J A B IR - Elrod JA FIR - Cummings, D E IR - Cummings DE FIR - Patchen Dellinger, E IR - Patchen Dellinger E FIR - Devlin, A IR - Devlin A FIR - Flum, D R IR - Flum DR FIR - Hammond, S IR - Hammond S FIR - Kowdley, K IR - Kowdley K FIR - Law, J IR - Law J FIR - Lucas, K IR - Lucas K FIR - MacDougall, A IR - MacDougall A FIR - Oelschlager, B IR - Oelschlager B FIR - Wright, A IR - Wright A FIR - Chang, L IR - Chang L FIR - Dasher, N IR - Dasher N FIR - Geary, S IR - Geary S FIR - Hunter, J IR - Hunter J FIR - Moonka, R IR - Moonka R FIR - Seibenick, O A IR - Seibenick OA FIR - Thirlby, R IR - Thirlby R FIR - Belle, S H IR - Belle SH FIR - Caporali, M IR - Caporali M FIR - King, W C IR - King WC FIR - Kip, K IR - Kip K FIR - Koozer, L IR - Koozer L FIR - Leishear, K IR - Leishear K FIR - Martin, D IR - Martin D FIR - Mercurio, R IR - Mercurio R FIR - Selzer, F IR - Selzer F FIR - Wahed, A S IR - Wahed AS FIR - Evans, M IR - Evans M FIR - Horlick, M IR - Horlick M FIR - Miles, C W IR - Miles CW FIR - Staten, M A IR - Staten MA FIR - Yanovski, S Z IR - Yanovski SZ FIR - Kleiner, D E IR - Kleiner DE EDAT- 2009/07/31 09:00 MHDA- 2009/08/07 09:00 PMCR- 2010/04/14 CRDT- 2009/07/31 09:00 PHST- 2009/07/31 09:00 [entrez] PHST- 2009/07/31 09:00 [pubmed] PHST- 2009/08/07 09:00 [medline] PHST- 2010/04/14 00:00 [pmc-release] AID - 361/5/445 [pii] AID - 10.1056/NEJMoa0901836 [doi] PST - ppublish SO - N Engl J Med. 2009 Jul 30;361(5):445-54. doi: 10.1056/NEJMoa0901836. PMID- 36430914 OWN - NLM STAT- MEDLINE DCOM- 20221129 LR - 20221213 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 23 IP - 22 DP - 2022 Nov 20 TI - A Multi-Scale Study on Deformation and Failure Process of Metallic Structures in Extreme Environment. LID - 10.3390/ijms232214437 [doi] LID - 14437 AB - It is a macro-micro model study for defect initiation, growth and crack propagation of metallic truss structure under high engine temperature and pressure conditions during the reentry atmosphere. Till now, the multi-scale simulation methods for these processes are still unclear. We explore the deformation and failure processes from macroscale to nanoscale using the Gas-Kinetic Unified Algorithm (GKUA) and all-atomic, molecular dynamic (MD) simulation method. The behaviors of the dislocations, defect evolution and crack propagation until failure for Aluminum-Magnesium (Al-Mg) alloy are considered with the different temperature background and strain fields. The results of distributions of temperature and strain field in the aerodynamic environment obtained by molecular dynamics simulations are in good agreement with those obtained from the macroscopic Boltzmann method. Compared to the tensile loading, the alloy structure is more sensitive to compression loading. The polycrystalline Al-Mg alloy has higher yield strength with a larger grain size. It is due to the translation of plastic deformation mode from grain boundary (GB) sliding to dislocation slip and the accumulation of dislocation line. Our findings have paved a new way to analyze and predict the metallic structural failure by micro-scale analysis under the aerodynamic thermal extreme environment of the reentry spacecraft on service expiration. FAU - Li, Zhi-Hui AU - Li ZH AD - China Aerodynamics Research and Development Center, Mianyang 621000, China. AD - National Laboratory for Computational Fluid Dynamics, Beijing 100191, China. FAU - Lu, Chenchen AU - Lu C AD - Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi 214122, China. FAU - Shi, Aiqiang AU - Shi A AD - Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi 214122, China. FAU - Zhao, Sihan AU - Zhao S AD - Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi 214122, China. FAU - Ou, Bingxian AU - Ou B AD - Special Equipment Safety Supervision Inspection Institute of Jiangsu Province, National Graphene Products Quality Inspection and Testing Center, Wuxi 214174, China. FAU - Wei, Ning AU - Wei N AD - Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi 214122, China. LA - eng GR - 2020-ZKZX-5011/Projects of the Manned Space Engineering Technology/ GR - FMZ202001/Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology/ GR - FMZ202009/Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology/ GR - KJ21125038/Science and technology project of Jiangsu Provincial Bureau of market supervision/ GR - KJ(Y)2020038/Science and technology project of Special Equipment Safety Supervision Inspection Institute of Jiangsu Province/ PT - Journal Article DEP - 20221120 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Plastics) RN - 0 (Alloys) RN - 0 (Antacids) SB - IM MH - *Plastics MH - *Extreme Environments MH - Alloys MH - Kinetics MH - Molecular Dynamics Simulation MH - Antacids MH - Edible Grain PMC - PMC9699454 OTO - NOTNLM OT - hypersonic reentry aerothermodynamic environment OT - mechanical response behavior OT - molecular dynamics simulation OT - numerical simulation COIS- The authors declare no conflict of interest. EDAT- 2022/11/27 06:00 MHDA- 2022/11/30 06:00 PMCR- 2022/11/20 CRDT- 2022/11/26 01:20 PHST- 2022/07/23 00:00 [received] PHST- 2022/10/18 00:00 [revised] PHST- 2022/11/03 00:00 [accepted] PHST- 2022/11/26 01:20 [entrez] PHST- 2022/11/27 06:00 [pubmed] PHST- 2022/11/30 06:00 [medline] PHST- 2022/11/20 00:00 [pmc-release] AID - ijms232214437 [pii] AID - ijms-23-14437 [pii] AID - 10.3390/ijms232214437 [doi] PST - epublish SO - Int J Mol Sci. 2022 Nov 20;23(22):14437. doi: 10.3390/ijms232214437. PMID- 33962701 OWN - NLM STAT- MEDLINE DCOM- 20210511 LR - 20210511 IS - 1749-9216 (Print) IS - 1749-9216 (Linking) VI - 14 IP - 4 DP - 2021 Jan 1 TI - Hostile environment awareness training: Building individual awareness while addressing organisational resilience. PG - 310-332 AB - Humanitarian aid and development is a multibillion-dollar sector, representing millions of organisations, with hundreds of millions of employees and volunteers operating worldwide. The community is, by its very nature, drawn towards danger, supporting vulnerable parties in high-risk areas. In the face of complex global health emergencies, natural disasters and deteriorating security conditions, the imperative for individuals to deploy to, or work in, increasingly fragile and hostile environments is growing. At the same time, expectations regarding the sector's duty of care are mounting, and employees, families, donors and governments are holding organisations increasingly accountable for their actions. Where an organisation fails - or is perceived to have failed - the people it is supposed to protect, it can face catastrophic litigation and reputational harm. Hostile environment awareness training is part of the duty-of-care strategy for those working in, or travelling to, high to extreme-risk environments. It addresses tactical-level risks by raising the awareness and competency of the individual in identifying, controlling and reacting to security and safety risks. In doing so, it concurrently reduces enterprise-level risks to the organisation. This paper discusses what drives the increasing need for hostile environment awareness training (HEAT), the value it brings in terms of duty of care and organisational resilience, what technical content and immersive learning should be included within a HEAT curriculum, and the challenges organisations face when implementing instruction programme at the global and multicultural level. FAU - Blyth, Michael AU - Blyth M AD - Risk and Strategic Management Corp. FAU - Bosch, Donald S AU - Bosch DS AD - Humanitarian Psychological Services. FAU - Williams, Chris AU - Williams C AD - CARE Security Unit, CARE. FAU - Dreyer, Andries AU - Dreyer A AD - World Vision. FAU - Hales, Aidan AU - Hales A AD - Kingwood, TX 77345. FAU - Mallett, Simon AU - Mallett S AD - Risk and Strategic Management. LA - eng PT - Journal Article PL - England TA - J Bus Contin Emer Plan JT - Journal of business continuity & emergency planning JID - 101509784 SB - IM MH - *Disaster Planning MH - Global Health MH - Humans MH - Organizations EDAT- 2021/05/09 06:00 MHDA- 2021/05/12 06:00 CRDT- 2021/05/08 06:12 PHST- 2021/05/08 06:12 [entrez] PHST- 2021/05/09 06:00 [pubmed] PHST- 2021/05/12 06:00 [medline] PST - ppublish SO - J Bus Contin Emer Plan. 2021 Jan 1;14(4):310-332. PMID- 20052430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20211020 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 2 DP - 2009 Nov 11 TI - A pilot field evaluation on heat stress in sugarcane workers in Costa Rica: What to do next? LID - 10.3402/gha.v2i0.2062 [doi] AB - BACKGROUND: Climate change is producing major impacts including increasing temperatures in tropical countries, like Costa Rica, where the sugarcane industry employs thousands of workers who are exposed to extreme heat. OBJECTIVES: This article outlines a pilot qualitative evaluation of working conditions and heat in the sugarcane industry. DESIGN: A literature review, direct observations and exploratory interviews with workers were conducted to reach a preliminary understanding of the dimensions of heat-related health issues in the sugarcane industry, as a basis for the design of future studies. RESULTS: The industry employs temporary workers from Nicaragua and Costa Rica as well as year-round employees. Temporary employees work 12-hour shifts during the harvest and processing ('zafra') season. In many cases, sugarcane field workers are required to carry their own water and often have no access to shade. Sugar mill workers are exposed to different levels of heat stress depending upon their job tasks, with the most intense heat and workload experienced by the oven ('caldera') cleaners. CONCLUSIONS: Research is needed to achieve better understanding of the multiple factors driving and interacting with heat exposures in the sugarcane industry in order to improve the health and safety of workers while maintaining worker productivity. FAU - Crowe, Jennifer AU - Crowe J AD - Program on Work and Health in Central America (SALTRA), Central American Institute for Studies in Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica. FAU - van Wendel de Joode, Berna AU - van Wendel de Joode B FAU - Wesseling, Catharina AU - Wesseling C LA - eng PT - Journal Article DEP - 20091111 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 PMC - PMC2799305 OTO - NOTNLM OT - Central America OT - Costa Rica OT - agriculture OT - climate change OT - heat exposure OT - heat stress OT - sugarcane EDAT- 2010/01/07 06:00 MHDA- 2010/01/07 06:01 PMCR- 2009/11/11 CRDT- 2010/01/07 06:00 PHST- 2009/07/31 00:00 [received] PHST- 2009/09/25 00:00 [revised] PHST- 2009/09/29 00:00 [accepted] PHST- 2010/01/07 06:00 [entrez] PHST- 2010/01/07 06:00 [pubmed] PHST- 2010/01/07 06:01 [medline] PHST- 2009/11/11 00:00 [pmc-release] AID - GHA-2-2062 [pii] AID - 10.3402/gha.v2i0.2062 [doi] PST - epublish SO - Glob Health Action. 2009 Nov 11;2. doi: 10.3402/gha.v2i0.2062. PMID- 25057582 STAT- Publisher ISBN- 0-309-07585-8 PB - National Academies Press (US) DP - 2001 BTI - Safe Passage: Astronaut Care for Exploration Missions AB - Safe Passage: Astronaut Care for Exploration Missions sets forth a vision for space medicine as it applies to deep space voyage. As space missions increase in duration from months to years and extend well beyond Earth’s orbit, so will the attendant risks of working in these extreme and isolated environmental conditions. Hazards to astronaut health range from greater radiation exposure and loss of bone and muscle density to intensified psychological stress from living with others in a confined space. Going beyond the body of biomedical research, the report examines existing space medicine clinical and behavioral research and health care data and the policies attendant to them. It describes why not enough is known today about the dangers of prolonged travel to enable humans to venture into deep space in a safe and sane manner. The report makes a number of recommendations concerning NASA’s structure for clinical and behavioral research, on the need for a comprehensive astronaut health care system and on an approach to communicating health and safety risks to astronauts, their families, and the public. CI - Copyright© 2001 by the National Academy of Sciences. All rights reserved. FED - Ball, John R ED - Ball JR FED - Evans, Charles H Jr ED - Evans CH Jr CN - Institute of Medicine (US) Committee on Creating a Vision for Space Medicine During Travel Beyond Earth Orbit LA - eng PT - Review PT - Book PL - Washington (DC) EDAT- 2001/01/01 00:00 CRDT- 2001/01/01 00:00 AID - NBK223783 [bookaccession] AID - 10.17226/10218 [doi] PMID- 36363068 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221117 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 15 IP - 21 DP - 2022 Oct 25 TI - Numerical Simulation and Analytical Prediction of Residual Strength for Elbow Pipes with Erosion Defects. LID - 10.3390/ma15217479 [doi] LID - 7479 AB - It is well known that the safety and reliability of pipeline transportation are crucial. We are aiming at the problem that the residual life and residual strength of the defective elbow pipes are difficult to predict and usually need to be obtained through experiments. Consequently, a combined method of numerical simulation technology combined with a genetic algorithm to optimize neural network extreme learning machine (GA-ELM) is proposed. Firstly, the erosion characteristics of elbow pipes with different defects under the conditions of different impurity particle flow rates, particle sizes, and mass flow rates are analyzed by numerical simulation. At the same time, the effects of erosion defects of different sizes on the equivalent stress and residual strength of elbow pipes are also studied. Based on numerical simulation data, the extreme learning machine prediction model optimized by a genetic algorithm is used to predict the erosion rate, residual life, and residual strength and compared with the traditional ELM network model. The results show that residual strength of the elbow pipes with the increase of the depth and length of the defect, and increases with the increase of the width of the defect; the GA-ELM model can not only effectively predict the erosion rate, residual life and residual strength of defective elbow pipes, moreover its prediction accuracy is better than the traditional ELM model. FAU - Sun, Chao AU - Sun C AUID- ORCID: 0000-0003-4183-7168 AD - School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China. FAU - Wang, Qi AU - Wang Q AD - School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China. FAU - Li, Yuelin AU - Li Y AD - School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China. FAU - Li, Yingqi AU - Li Y AD - School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China. FAU - Liu, Yuechan AU - Liu Y AD - School of Measurement and Communication Engineering, Harbin University of Science and Technology, Harbin 150080, China. LA - eng GR - 11704090/National Natural Science Foundation of China/ GR - UNPYSCT-2018207/University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province/ GR - LH2020A016/Nature Scientific Foundation of Heilongjiang Province/ PT - Journal Article DEP - 20221025 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC9658861 OTO - NOTNLM OT - analytical prediction OT - elbow pipes OT - erosion defects OT - failure pressure OT - residual strength COIS- The authors declare no conflict of interest. EDAT- 2022/11/12 06:00 MHDA- 2022/11/12 06:01 PMCR- 2022/10/25 CRDT- 2022/11/11 01:34 PHST- 2022/09/10 00:00 [received] PHST- 2022/10/11 00:00 [revised] PHST- 2022/10/17 00:00 [accepted] PHST- 2022/11/11 01:34 [entrez] PHST- 2022/11/12 06:00 [pubmed] PHST- 2022/11/12 06:01 [medline] PHST- 2022/10/25 00:00 [pmc-release] AID - ma15217479 [pii] AID - materials-15-07479 [pii] AID - 10.3390/ma15217479 [doi] PST - epublish SO - Materials (Basel). 2022 Oct 25;15(21):7479. doi: 10.3390/ma15217479. PMID- 29978127 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240318 IS - 2450-7393 (Print) IS - 2450-8608 (Electronic) IS - 2450-7393 (Linking) VI - 62 IP - 1 DP - 2018 Mar TI - Ready-to-eat Meat Products As a Source of Listeria Monocytogenes. PG - 49-55 LID - 10.1515/jvetres-2018-0007 [doi] AB - In 2015 in the European Union member states listeriosis caused 270 deaths. Food is the route of transmission in 99% of all human infection cases. Several studies from different countries have shown that the presence of Listeria monocytogenes in food can be as high as 58.3%. One of the most important ways to protect food from these microorganisms is to prevent the spread of the bacteria at processing plants at different stages of food production chain. The ability of L. monocytogenes to survive in extreme conditions and to form biofilms on various surfaces is a significant challenge for food safety. Removal of these bacteria from niches in processing plants is difficult and requires the use of sanitisers and precise equipment cleaning. The presence of L. monocytogenes in processing environment at slaughterhouses, deli meat factories or in retail may be a reason of cross-contamination. Proper hygienic systems applied by workers in food preparing places and knowledge about different routes of spreading of these bacteria may effectively decrease the risk of food contamination. Standardised legal regulations and control of meat product manufacture should be a fundamental way to protect food from L. monocytogenes contamination. FAU - Kurpas, Monika AU - Kurpas M AD - Department of Hygiene of Food of Animal Origin, National Veterinary Research Institute, 24-100 Pulawy, Poland. FAU - Wieczorek, Kinga AU - Wieczorek K AD - Department of Hygiene of Food of Animal Origin, National Veterinary Research Institute, 24-100 Pulawy, Poland. FAU - Osek, Jacek AU - Osek J AD - Department of Hygiene of Food of Animal Origin, National Veterinary Research Institute, 24-100 Pulawy, Poland. LA - eng PT - Journal Article DEP - 20180330 PL - Poland TA - J Vet Res JT - Journal of veterinary research JID - 101696630 PMC - PMC5957461 OTO - NOTNLM OT - Listeria monocytogenes OT - contamination OT - food chain OT - ready-to-eat meat products COIS- Conflict of Interests Statement: The authors declare that there is no conflict of interests regarding the publication of this article. EDAT- 2018/07/07 06:00 MHDA- 2018/07/07 06:01 PMCR- 2018/03/30 CRDT- 2018/07/07 06:00 PHST- 2017/09/20 00:00 [received] PHST- 2018/02/12 00:00 [accepted] PHST- 2018/07/07 06:00 [entrez] PHST- 2018/07/07 06:00 [pubmed] PHST- 2018/07/07 06:01 [medline] PHST- 2018/03/30 00:00 [pmc-release] AID - jvetres-2018-0007 [pii] AID - 10.1515/jvetres-2018-0007 [doi] PST - epublish SO - J Vet Res. 2018 Mar 30;62(1):49-55. doi: 10.1515/jvetres-2018-0007. eCollection 2018 Mar. PMID- 16358512 OWN - NLM STAT- MEDLINE DCOM- 20060313 LR - 20051219 IS - 0253-1933 (Print) IS - 0253-1933 (Linking) VI - 24 IP - 2 DP - 2005 Aug TI - Animal welfare: the role and perspectives of the meat and livestock sector. PG - 613-23 AB - Those in the livestock industry involved in rearing animals and in producing milk, meat and eggs, must respond to two demands: one expressed by consumers, and the other by the public. Regarding consumers, demand for food produced by the livestock industry has shown steady growth for a century. Over the last few decades, this growth has been sustained by the developing countries, and is based mainly on pig and poultry production, which provides cheaper products. Regarding the public, society is showing greater concern about the conditions in which livestock is reared, transported and slaughtered. The public demands not only that ill treatment of animals be fought against and penalised, but also that any unnecessary suffering should be avoided and even that animals should be guaranteed a certain degree of 'comfort'. Animal health, the most important aspect of their welfare, has vastly improved, as has the care of sick or injured animals. At the same time, the latest amenities used in livestock rearing, transport and slaughter are helping to eliminate situations involving extreme stress and suffering. Finally, the motivation of industry players and the safety of those who work with livestock must be taken into consideration. Training of personnel and the implementation of guides to good practice or of quality control do as much to improve animal welfare as do overzealous regulations. FAU - Seng, P M AU - Seng PM AD - International Meat Secretariat, 6, rue de la Victoire, 75009 Paris, France. FAU - Laporte, R AU - Laporte R LA - eng PT - Journal Article PT - Review PL - France TA - Rev Sci Tech JT - Revue scientifique et technique (International Office of Epizootics) JID - 8712301 SB - IM MH - Abattoirs/standards MH - Animal Husbandry/methods/standards MH - *Animal Welfare MH - Animals MH - Animals, Domestic MH - Dairying/methods/standards MH - Food-Processing Industry/*methods/*standards/trends MH - Humans MH - Meat/*standards MH - Occupational Health MH - *Public Opinion MH - Transportation/standards RF - 4 EDAT- 2005/12/20 09:00 MHDA- 2006/03/15 09:00 CRDT- 2005/12/20 09:00 PHST- 2005/12/20 09:00 [pubmed] PHST- 2006/03/15 09:00 [medline] PHST- 2005/12/20 09:00 [entrez] PST - ppublish SO - Rev Sci Tech. 2005 Aug;24(2):613-23. PMID- 39882292 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250131 IS - 2516-5542 (Electronic) IS - 2516-5542 (Linking) VI - 7 IP - 2 DP - 2024 TI - Modern perspective of the Rice Diet for hypertension and other metabolic diseases. PG - e000949 LID - 10.1136/bmjnph-2024-000949 [doi] LID - e000949 AB - BACKGROUND: In the early 1940s, before antihypertensive drugs were available, the Rice Diet Programme (RDP) was developed to treat severe hypertension and, later, diabetes and obesity. Despite significant advancements in dietary management for these conditions since then, debates remain regarding the proper guidelines for sodium and macronutrients intakes. The patient care records of RDP offer a unique source of longitudinal examination of a very low sodium (<10 mmol/day), fat, cholesterol and protein diet on blood pressure (BP), other health markers and survival. METHODS: In 2019, the Rice Diet Database Project (RDDP) digitised handwritten patient care records and retinal photographs of 17 487 RDP participants, establishing a digital database for analyses. Manual transcription accuracy exceeded 97%. We used regression models to investigate the impact of dietary adherence on systolic BP (SBP) and body weight. Further, we performed Kaplan-Meier survival analysis to compare 5-year survival probability of participants defined by baseline level of SBP. RESULTS: The database encompasses a wide array of health markers, including BP, weight, urine chloride (UCl) concentration and retinal features that offer a unique resource for studying the impact of the RDP on hypertension, diabetes and obesity. Initial analysis shows reductions in BP and weight as well as improved survival in participants with severe hypertension, underscoring the effectiveness of the diet. The data also permit examining the safety of extreme dietary sodium reduction.The database has numerous strengths (large patient population; extensive, long-term measurements and the use of UCl excretion to document dietary adherence) and limitations (missing data; temporal changes in methodologies over 50 years and lack of control subjects). CONCLUSION: The RDDP database allows exploration of the effects of a diet extremely low in sodium, protein, fat and cholesterol on health indicators and patient survival. This report highlights the database's potential for detailed and intricate future analyses. CI - Copyright © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group Group. FAU - Sommerfeld, Romeo AU - Sommerfeld R AUID- ORCID: 0009-0005-3464-6787 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Ermler, Paul AU - Ermler P AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Fehr, Jana AU - Fehr J AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Bergner, Benjamin AU - Bergner B AUID- ORCID: 0000-0002-0572-840X AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Lopez, David AU - Lopez D AD - Medicine, Nephrology Division, Duke University Medical Center, Durham, North Carolina, USA. FAU - Sanoff, Scott AU - Sanoff S AD - Medicine, Nephrology Division, Duke University Medical Center, Durham, North Carolina, USA. FAU - Neelon, Francis A AU - Neelon FA AUID- ORCID: 0000-0003-2358-2763 AD - Duke University School of Medicine, Durham, North Carolina, USA. FAU - Kuo, Anthony AU - Kuo A AUID- ORCID: 0009-0008-3375-9909 AD - Duke University School of Medicine, Durham, North Carolina, USA. FAU - McDowell, William AU - McDowell W AD - Medicine, Nephrology Division, Duke University Medical Center, Durham, North Carolina, USA. FAU - Li, Yi-Ju AU - Li YJ AUID- ORCID: 0000-0001-6996-4834 AD - Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina, USA. FAU - Fox, Smilla AU - Fox S AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Ghajar, Abdullatif AU - Ghajar A AUID- ORCID: 0009-0000-2333-8141 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Gensch, Elena AU - Gensch E AUID- ORCID: 0009-0004-0878-2761 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Lorenz, Cedric AU - Lorenz C AUID- ORCID: 0009-0006-4753-4220 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Preiss, Martin AU - Preiss M AUID- ORCID: 0009-0003-9045-1402 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Richter, Tom AU - Richter T AUID- ORCID: 0009-0009-5547-2893 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Luft, Friedrich C AU - Luft FC AD - Max Delbrück Center for Molecular Medicine (MDC), Experimental and Clinical Research Center (ECRC), Berlin, Germany. FAU - Klemmer, Philip AU - Klemmer P AUID- ORCID: 0009-0004-6517-0788 AD - Medicine, University of North Carolina, Chapel Hill, North Carolina, USA. FAU - Bohannon, Anastacia AU - Bohannon A AUID- ORCID: 0009-0000-4401-3426 AD - Medicine, Nephrology Division, Duke University Medical Center, Durham, North Carolina, USA. FAU - Lippert, Christoph AU - Lippert C AUID- ORCID: 0000-0001-6363-2556 AD - Hasso Plattner Institute for Digital Engineering, University of Postdam, Potsdam, Germany. FAU - Lin, Pao-Hwa AU - Lin PH AUID- ORCID: 0000-0001-5982-9241 AD - Medicine, Nephrology Division, Duke University Medical Center, Durham, North Carolina, USA. LA - eng PT - Journal Article DEP - 20241225 PL - England TA - BMJ Nutr Prev Health JT - BMJ nutrition, prevention & health JID - 101769223 PMC - PMC11773661 OTO - NOTNLM OT - Blood pressure lowering OT - Dietary patterns OT - Nutritional treatment COIS- No, there are no competing interests. EDAT- 2025/01/30 11:07 MHDA- 2025/01/30 11:08 PMCR- 2024/12/25 CRDT- 2025/01/30 04:32 PHST- 2024/05/02 00:00 [received] PHST- 2024/11/24 00:00 [accepted] PHST- 2025/01/30 11:08 [medline] PHST- 2025/01/30 11:07 [pubmed] PHST- 2025/01/30 04:32 [entrez] PHST- 2024/12/25 00:00 [pmc-release] AID - bmjnph-2024-000949 [pii] AID - 10.1136/bmjnph-2024-000949 [doi] PST - epublish SO - BMJ Nutr Prev Health. 2024 Dec 25;7(2):e000949. doi: 10.1136/bmjnph-2024-000949. eCollection 2024. PMID- 28712283 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2234-1900 (Print) IS - 2234-3164 (Electronic) IS - 2234-1900 (Linking) VI - 35 IP - 2 DP - 2017 Jun TI - Stereotactic radiotherapy of the prostate: fractionation and utilization in the United States. PG - 137-143 LID - 10.3857/roj.2017.02026 [doi] AB - PURPOSE: To analyze the utilization and fractionation of extreme hypofractionation via stereotactic body radiotherapy (SBRT) in the treatment of prostate cancer. MATERIALS AND METHODS: Data was analyzed on men diagnosed with localized prostate cancer between 2004-2012 and treated with definitive-intent radiation therapy, as captured in the National Cancer Database. This database is a hospital-based registry that collects an estimated 70% of all diagnosed malignancies in the United States. RESULTS: There were 299,186 patients identified, of which 4,962 (1.7%) were identified as receiving SBRT as primary treatment. Of those men, 2,082 had low risk disease (42.0%), 2,201 had intermediate risk disease (44.4%), and 679 had high risk disease (13.7%). The relative utilization of SBRT increased from 0.1% in 2004 to 4.0% in 2012. Initially SBRT was more commonly used in academic programs, though as time progressed there was a shift to favor an increased absolute number of men treated in the community setting. Delivery of five separate treatments was the most commonly utilized fractionation pattern, with 4,635 patients (91.3%) receiving this number of treatments. The most common dosing pattern was 725 cGy × 5 fractions (49.6%) followed by 700 cGy × 5 fractions (21.3%). CONCLUSIONS: Extreme hypofractionation via SBRT is slowly increasing acceptance. Currently 700-725 cGy × 5 fractions appears to be the most commonly employed scheme. As further long-term data regarding the safety and efficacy emerges, the relative utilization of this modality is expected to continue to increase. FAU - P Weiner, Joseph AU - P Weiner J AD - Department of Radiation Oncology, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. AD - Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA. FAU - Schwartz, David AU - Schwartz D AD - Department of Radiation Oncology, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. AD - Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA. FAU - Shao, Meng AU - Shao M AD - Department of Radiation Oncology, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. AD - Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA. FAU - Osborn, Virginia AU - Osborn V AD - Department of Radiation Oncology, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. AD - Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA. FAU - Choi, Kwang AU - Choi K AD - Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA. FAU - Schreiber, David AU - Schreiber D AD - Department of Radiation Oncology, Veterans Affairs New York Harbor Healthcare System, Brooklyn, NY, USA. AD - Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY, USA. LA - eng PT - Journal Article DEP - 20170630 PL - Korea (South) TA - Radiat Oncol J JT - Radiation oncology journal JID - 101577577 PMC - PMC5518450 OTO - NOTNLM OT - Fractionation OT - National Cancer Database OT - Prostate cancer OT - Stereotactic body radiation therapy OT - Utilization COIS- Conflict of Interest No potential conflict of interest relevant to this article was reported. EDAT- 2017/07/18 06:00 MHDA- 2017/07/18 06:01 PMCR- 2017/06/01 CRDT- 2017/07/18 06:00 PHST- 2016/11/14 00:00 [received] PHST- 2017/01/25 00:00 [revised] PHST- 2017/02/06 00:00 [accepted] PHST- 2017/07/18 06:00 [entrez] PHST- 2017/07/18 06:00 [pubmed] PHST- 2017/07/18 06:01 [medline] PHST- 2017/06/01 00:00 [pmc-release] AID - roj-2017-02026 [pii] AID - 10.3857/roj.2017.02026 [doi] PST - ppublish SO - Radiat Oncol J. 2017 Jun;35(2):137-143. doi: 10.3857/roj.2017.02026. Epub 2017 Jun 30. PMID- 34885550 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211214 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 14 IP - 23 DP - 2021 Dec 2 TI - Recruiting Perovskites to Degrade Toxic Trinitrotoluene. LID - 10.3390/ma14237387 [doi] LID - 7387 AB - Everybody knows TNT, the most widely used explosive material and a universal measure of the destructiveness of explosions. A long history of use and extensive manufacture of toxic TNT leads to the accumulation of these materials in soil and groundwater, which is a significant concern for environmental safety and sustainability. Reliable and cost-efficient technologies for removing or detoxifying TNT from the environment are lacking. Despite the extreme urgency, this remains an outstanding challenge that often goes unnoticed. We report here that highly controlled energy release from explosive molecules can be accomplished rather easily by preparing TNT-perovskite mixtures with a tailored perovskite surface morphology at ambient conditions. These results offer new insight into understanding the sensitivity of high explosives to detonation initiation and enable many novel applications, such as new concepts in harvesting and converting chemical energy, the design of new, improved energetics with tunable characteristics, the development of powerful fuels and miniaturized detonators, and new ways for eliminating toxins from land and water. FAU - Mastrikov, Yuri A AU - Mastrikov YA AUID- ORCID: 0000-0001-6867-6769 AD - Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA. FAU - Tsyshevsky, Roman AU - Tsyshevsky R AD - Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA. FAU - Wang, Fenggong AU - Wang F AD - Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA. FAU - Kuklja, Maija M AU - Kuklja MM AUID- ORCID: 0000-0002-5047-7734 AD - Department of Materials Science and Engineering, University of Maryland, College Park, MD 20742, USA. LA - eng PT - Journal Article DEP - 20211202 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC8658843 OTO - NOTNLM OT - catalytic degradation OT - chemical decomposition mechanisms OT - high energy density materials OT - high explosives OT - reaction activation barriers and kinetics COIS- The authors declare no competing financial interests. EDAT- 2021/12/11 06:00 MHDA- 2021/12/11 06:01 PMCR- 2021/12/02 CRDT- 2021/12/10 01:07 PHST- 2021/10/21 00:00 [received] PHST- 2021/11/26 00:00 [revised] PHST- 2021/11/27 00:00 [accepted] PHST- 2021/12/10 01:07 [entrez] PHST- 2021/12/11 06:00 [pubmed] PHST- 2021/12/11 06:01 [medline] PHST- 2021/12/02 00:00 [pmc-release] AID - ma14237387 [pii] AID - materials-14-07387 [pii] AID - 10.3390/ma14237387 [doi] PST - epublish SO - Materials (Basel). 2021 Dec 2;14(23):7387. doi: 10.3390/ma14237387. PMID- 27497032 OWN - NLM STAT- MEDLINE DCOM- 20180321 LR - 20231213 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 572 DP - 2016 Dec 1 TI - The association between ambient temperature and out-of-hospital cardiac arrest in Guangzhou, China. PG - 114-118 LID - S0048-9697(16)31659-X [pii] LID - 10.1016/j.scitotenv.2016.07.205 [doi] AB - Out-of-hospital cardiac arrest (OHCA) is becoming a considerable public health burden worldwide. The seasonal variation of OHCA has been observed, but the potential effects of ambient temperature on OHCA were rarely investigated. We, therefore, aimed to evaluate the association between ambient temperature and OHCA in Guangzhou, China. We collected daily emergency ambulance dispatches for OHCA from the Guangzhou Emergency Center from January 1, 2008 to December 31, 2012. We analyzed the associations using the time-series method. We applied the generalized linear model combined with the distributed lag non-linear model to estimate the potentially non-linear and lagged effects of temperature on OHCA. Time trends, day of the week, and air pollutants were controlled as covariates. We identified a total of 4369 cases of OHCD. The associations between daily mean temperature and OHCA were generally J-shaped. Both low and high temperatures could increase the risk of OHCA. The effects were strongest on the concurrent day (lag 0) and lasted for 6 or 7days. The cumulative risks of extreme cold (1st percentile of temperature) and extreme heat (99th percentile of temperature) over lags 0-21days were 3.75 (95% confidence interval [CI]: 1.63, 8.63) and 2.45 (95%CI: 1.15, 5.33), respectively, compared with the referent temperature (28°C)·This study suggested that both cold and hot temperatures could significantly increase the risk of OHCA in Guangzhou, China. Our results might have important public health implications for the prevention of OHCA. CI - Copyright © 2016 Elsevier B.V. All rights reserved. FAU - Niu, Yue AU - Niu Y AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai 200032, China. FAU - Liu, Cong AU - Liu C AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China. FAU - Ran, Pixin AU - Ran P AD - State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China. FAU - Chen, Ailan AU - Chen A AD - Department of Cardiology, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 510120, China. FAU - Chen, Xinyu AU - Chen X AD - State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, China; Department of Pathogenic Biology, Guangzhou Hoffmann Institute of Immunology, Guangzhou Medical University, Guangzhou 511436, China. Electronic address: chenxinyu1357@163.com. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, and Key Lab of Health Technology Assessment of the Ministry of Health, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Fudan University, Shanghai 200032, China. Electronic address: kanh@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20160803 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - China/epidemiology MH - Extreme Cold/*adverse effects MH - Extreme Heat/*adverse effects MH - Humans MH - Incidence MH - Linear Models MH - Nonlinear Dynamics MH - Out-of-Hospital Cardiac Arrest/*epidemiology/etiology MH - Seasons MH - Urban Population/statistics & numerical data OTO - NOTNLM OT - Epidemiology OT - Out-of-hospital cardiac arrest OT - Temperature OT - Time series EDAT- 2016/08/09 06:00 MHDA- 2018/03/22 06:00 CRDT- 2016/08/07 06:00 PHST- 2016/04/03 00:00 [received] PHST- 2016/07/08 00:00 [revised] PHST- 2016/07/29 00:00 [accepted] PHST- 2016/08/09 06:00 [pubmed] PHST- 2018/03/22 06:00 [medline] PHST- 2016/08/07 06:00 [entrez] AID - S0048-9697(16)31659-X [pii] AID - 10.1016/j.scitotenv.2016.07.205 [doi] PST - ppublish SO - Sci Total Environ. 2016 Dec 1;572:114-118. doi: 10.1016/j.scitotenv.2016.07.205. Epub 2016 Aug 3. PMID- 19291742 OWN - NLM STAT- MEDLINE DCOM- 20090813 LR - 20171116 IS - 1526-4998 (Electronic) IS - 1526-498X (Linking) VI - 65 IP - 6 DP - 2009 Jun TI - Effects of chlorantraniliprole on eggs and larvae of Lobesia botrana (Denis & Schiffermüller) (Lepidoptera: Tortricidae). PG - 717-22 LID - 10.1002/ps.1744 [doi] AB - BACKGROUND: Chlorantraniliprole is a novel insecticide belonging to the class of selective ryanodine receptor agonists. The aims of this study were to evaluate the toxicity and the length of residual activity of chlorantraniliprole against the grapevine moth, Lobesia botrana (Denis & Schiffermüller), larvae and eggs, under laboratory and field conditions. RESULTS: Dose-response bioassays showed that chlorantraniliprole had a high level of toxicity to neonate larvae of L. botrana. In field trials, chlorantraniliprole applied at 35 mg AI L(-1) was as effective against the larvae as the commercial standard reference, chlorpyrifos-ethyl, and had a long-lasting effect. When applied at a field rate of 35 mg AI L(-1), chlorantraniliprole caused greater than 20% egg mortality. The toxic effect of chlorantraniliprole is completed by its substantial activity against neonates emerging from eggs. CONCLUSION: Chlorantraniliprole can be considered as a useful tool for L. botrana control, providing a new standard in efficacy and an extremely good residual control. The combined effects against eggs and larvae of grapevine moth should contribute to its efficacy in the field. The new mode of action of chlorantraniliprole and its safety to beneficials and non-target organisms would be extremely useful in IPM and for managing resistance to insecticides. FAU - Ioriatti, Claudio AU - Ioriatti C AD - Plant Protection Department, IASMA Research Centre, San Michele all'Adige (TN), Italy. claudio.ioriatti@iasma.it FAU - Anfora, Gianfranco AU - Anfora G FAU - Angeli, Gino AU - Angeli G FAU - Mazzoni, Valerio AU - Mazzoni V FAU - Trona, Federica AU - Trona F LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Pest Manag Sci JT - Pest management science JID - 100898744 RN - 0 (Insecticides) RN - 0 (ortho-Aminobenzoates) RN - 622AK9DH9G (chlorantranilipole) SB - IM MH - Animals MH - Biological Assay MH - Female MH - Insect Control MH - Insecticides/*pharmacology MH - Larva/drug effects MH - Male MH - Moths/*drug effects MH - Oviposition/drug effects MH - Ovum/drug effects MH - ortho-Aminobenzoates/*pharmacology EDAT- 2009/03/18 09:00 MHDA- 2009/08/14 09:00 CRDT- 2009/03/18 09:00 PHST- 2009/03/18 09:00 [entrez] PHST- 2009/03/18 09:00 [pubmed] PHST- 2009/08/14 09:00 [medline] AID - 10.1002/ps.1744 [doi] PST - ppublish SO - Pest Manag Sci. 2009 Jun;65(6):717-22. doi: 10.1002/ps.1744. PMID- 36466817 OWN - NLM STAT- MEDLINE DCOM- 20221206 LR - 20221206 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 13 DP - 2022 TI - Genetic dominance of transforming growth factor-β1 polymorphisms in chronic liver disease. PG - 1058532 LID - 10.3389/fimmu.2022.1058532 [doi] LID - 1058532 AB - Chronic liver disease (CLD) is an extremely common clinical condition accompanied by sustained inflammatory response leading to tissue damage. Transforming growth factor-β1 (TGF-β1) is known as a master immune regulator in CLDs, but the association between TGF-β1 polymorphisms and CLD risk is controversial and inconclusive, and the genetic dominance of CLDs remains unknown. In this study, the relationship between TGF-β1 polymorphisms and CLD susceptibility is systematically analyzed based on 35 eligible studies. Individuals with the TGF-β1-509 allele (TT or CT) or codon 10 allele (Pro/Pro) show an increased risk of CLDs. Subgroup analyses indicate TGF-β1-509C/T has a significant correlation with cirrhosis and chronic hepatitis C, codon 10 is associated with chronic hepatitis B occurrence, and codon 25 exhibits a relationship with autoimmune hepatitis risk. Missense mutations in G29E, A105S, D191N, and F321L of TGF-β1 are the genetic factors of HCC susceptibility. Furthermore, the TGF-β1 gene expression is significantly elevated in CLD patients, and the TGF-β1 codon 263 is located close to the region where the TGF-β1 dimerization interacts, indicating the TGF-β1 codon 263 variant may affect the secretion of TGF-β1 by altering its dimerization. Together, our findings provide new insights into the immune regulator gene TGF-β1 polymorphisms as susceptibility factors for CLD occurrence and regulators for TGF-β1 expression, which have implications for the regulation of immune factors during CLD development. CI - Copyright © 2022 Cai, Zha, Yang, Du, Dai, Yang, Wang, He and Weng. FAU - Cai, Xuanyan AU - Cai X AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Zha, Huiyan AU - Zha H AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Yang, Zhaoxu AU - Yang Z AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Du, Yiwen AU - Du Y AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Dai, Xiaoyang AU - Dai X AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Yang, Bo AU - Yang B AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - Wang, Jiajia AU - Wang J AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. FAU - He, Qiaojun AU - He Q AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Weng, Qinjie AU - Weng Q AD - Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221116 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Transforming Growth Factor beta1) SB - IM MH - Humans MH - Transforming Growth Factor beta1/genetics MH - *Carcinoma, Hepatocellular MH - *Liver Neoplasms/genetics MH - Polymorphism, Genetic MH - *Hepatitis, Autoimmune PMC - PMC9708878 OTO - NOTNLM OT - chronic liver disease OT - cirrhosis OT - polymorphisms OT - susceptibility OT - transforming growth factor-β1 COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/12/06 06:00 MHDA- 2022/12/07 06:00 PMCR- 2022/01/01 CRDT- 2022/12/05 04:12 PHST- 2022/09/30 00:00 [received] PHST- 2022/10/31 00:00 [accepted] PHST- 2022/12/05 04:12 [entrez] PHST- 2022/12/06 06:00 [pubmed] PHST- 2022/12/07 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2022.1058532 [doi] PST - epublish SO - Front Immunol. 2022 Nov 16;13:1058532. doi: 10.3389/fimmu.2022.1058532. eCollection 2022. PMID- 35542415 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2046-2069 (Electronic) IS - 2046-2069 (Linking) VI - 8 IP - 10 DP - 2018 Jan 29 TI - Dendrite formation in silicon anodes of lithium-ion batteries. PG - 5255-5267 LID - 10.1039/c7ra12690e [doi] AB - Rechargeable lithium-ion batteries require a vigorous improvement if we want to use them massively for high energy applications. Silicon and metal lithium anodes are excellent alternatives because of their large theoretical capacity when compared to graphite used in practically all rechargeable Li-ion batteries. However, several problems need to be addressed satisfactorily before a major fabrication effort can be launched; for instance, the growth of lithium dendrites is one of the most important to take care due to safety issues. In this work we attempt to predict the mechanism of dendrite growth by simulating possible behaviors of charge distributions in the anode of an already cracked solid electrolyte interphase of a nanobattery, which is under the application of an external field representing the charging of the battery; thus, elucidating the conditions for dendrite growth. The extremely slow drift velocity of the Li-ions of ∼1 mm per hour in a typical commercial Li-ion battery, makes the growth of a dendrite take a few hours; however, once a Li-ion arrives at an active site of the anode, it takes an extremely short time of ∼1 ps to react. This large difference in time-scales allows us to perform the molecular dynamics simulation of the ions at much larger drift velocities, so we can have valuable results in reasonable computational times. The conditions before the growth are assumed and conditions that do not lead to the growth are ignored. We performed molecular dynamics simulations of a pre-lithiated silicon anode with a Li : Si ratio of 21 : 5, corresponding to a fully charged battery. We simulate the dendrite growth by testing a few charge distributions in a nanosized square representing a crack of the solid electrolyte interphase, which is where the electrolyte solution comes into direct contact with the LiSi alloy anode. Depending on the selected charge distributions for such an anode surface, the dendrites grow during the simulation when an external field is applied. We found that dendrites grow when strong deviations of charge distributions take place on the surface of the crack. Results from this work are important in finding ways to constrain lithium dendrite growth using tailored coatings or pre-coatings covering the LiSi alloy anode. CI - This journal is © The Royal Society of Chemistry. FAU - Selis, Luis A AU - Selis LA AD - Department of Chemical Engineering, Department of Electrical and Computer Engineering, Department of Materials Science and Engineering, Texas A&M University College Station TX 77843 USA seminario@tamu.edu +1 979 845-3301. FAU - Seminario, Jorge M AU - Seminario JM AUID- ORCID: 0000-0001-5397-9281 AD - Department of Chemical Engineering, Department of Electrical and Computer Engineering, Department of Materials Science and Engineering, Texas A&M University College Station TX 77843 USA seminario@tamu.edu +1 979 845-3301. LA - eng PT - Journal Article DEP - 20180129 PL - England TA - RSC Adv JT - RSC advances JID - 101581657 PMC - PMC9078120 COIS- The authors declare that there is no conflict of interests regarding the publication of this article. EDAT- 2018/01/29 00:00 MHDA- 2018/01/29 00:01 PMCR- 2018/01/29 CRDT- 2022/05/11 04:08 PHST- 2017/11/22 00:00 [received] PHST- 2018/01/23 00:00 [accepted] PHST- 2022/05/11 04:08 [entrez] PHST- 2018/01/29 00:00 [pubmed] PHST- 2018/01/29 00:01 [medline] PHST- 2018/01/29 00:00 [pmc-release] AID - c7ra12690e [pii] AID - 10.1039/c7ra12690e [doi] PST - epublish SO - RSC Adv. 2018 Jan 29;8(10):5255-5267. doi: 10.1039/c7ra12690e. eCollection 2018 Jan 29. PMID- 16253927 OWN - NLM STAT- MEDLINE DCOM- 20060425 LR - 20220311 IS - 1547-5271 (Print) IS - 1547-5271 (Linking) VI - 2 IP - 2 Suppl DP - 2005 Nov TI - Use of preclinical assays to predict risk of drug-induced torsades de pointes. PG - S16-22 AB - Numerous medications, including drugs prescribed for noncardiac indications, can induce electrophysiologic changes that trigger the rare, malignant polymorphic ventricular tachyarrhythmia known as torsades de pointes (TdP). Although the exact relationship between electrophysiologic events and the development of TdP is not defined, prolongation of the QT interval and inhibition of the rapidly activating potassium current I(Kr) by drugs may be associated with an increased risk of TdP. The ability of a drug to reduce I(Kr) and prolong the QT interval often is considered to predict the likelihood that the drug will cause TdP in humans. However, these surrogate measures of the drug-induced risk of causing TdP, and therefore of drug safety, now are recognized to be imperfect predictors of drug safety. New preclinical models should be used to assess drug risk, including preparations, conditions, and measurements used by basic research scientists to produce ventricular polymorphic arrhythmias in the laboratory. In this review, we discuss the task of assessing the arrhythmogenic potential of a drug. Assays of drug effect to induce early afterdepolarizations and ectopic beats and/or to increase the dispersion of ventricular repolarization when "repolarization reserve" is reduced appear to be the best predictors of the drug-induced risk of TdP. Current experimental models and protocols, especially those using conditions wherein the net repolarizing current is reduced, can detect the potential for a drug to induce TdP, even when the potential is extremely low. FAU - Belardinelli, Luiz AU - Belardinelli L AD - CV Therapeutics Inc., 3172 Porter Drive, Palo Alto, CA 94304, USA. luiz.belardinelli@cvt.com FAU - Shryock, John C AU - Shryock JC FAU - Wu, Lin AU - Wu L FAU - Song, Yejia AU - Song Y LA - eng PT - Journal Article PT - Review PL - United States TA - Heart Rhythm JT - Heart rhythm JID - 101200317 RN - 0 (Anti-Arrhythmia Agents) SB - IM MH - Anti-Arrhythmia Agents/administration & dosage/adverse effects MH - Electrophysiology MH - Heart Conduction System/drug effects/physiology MH - Humans MH - Predictive Value of Tests MH - Risk Assessment MH - Torsades de Pointes/*chemically induced/*physiopathology RF - 18 EDAT- 2005/10/29 09:00 MHDA- 2006/04/28 09:00 CRDT- 2005/10/29 09:00 PHST- 2004/08/18 00:00 [received] PHST- 2005/10/29 09:00 [pubmed] PHST- 2006/04/28 09:00 [medline] PHST- 2005/10/29 09:00 [entrez] AID - S1547-5271(04)00763-5 [pii] AID - 10.1016/j.hrthm.2004.10.032 [doi] PST - ppublish SO - Heart Rhythm. 2005 Nov;2(2 Suppl):S16-22. doi: 10.1016/j.hrthm.2004.10.032. PMID- 32409836 OWN - NLM STAT- MEDLINE DCOM- 20210623 LR - 20210623 IS - 1742-3406 (Electronic) IS - 0144-8420 (Linking) VI - 189 IP - 3 DP - 2020 Jul 17 TI - EXTREMELY LOW FREQUENCY ELECTROMAGNETIC FIELD EXPOSURE MEASUREMENT IN THE VICINITY OF WIND TURBINES. PG - 395-400 LID - 10.1093/rpd/ncaa053 [doi] AB - BACKGROUND: There is an exponential growth of public concern worldwide regarding the exposure to electromagnetic fields (EMF) generated by wind turbines. The high concern of the general population enhances the fact that EMF exposure remains a crucial issue that demands specific actions and reliable data to evaluate possible health hazards. MATERIALS AND METHODS: EMF exposure measurements were conducted in two wind farm (W/F) areas in Greece. The magnetic field strength concentrated in the proximity of 22 wind turbines (20 type of Gamesa Eolica Siemens of total power of 17 MW and 2 type of E53 Enercon, 800 KW each). Measurements were conducted using a Narda-NBM-550 basic unit (Narda Safety Test Solutions Company) using EHP-50F probe. The EMF exposure measurements were processed applying the weighted peak method (WPM), according to the 2013/35/EU Directive. WPM provides correction of the measured value of pulse signals, taking into account the phases of the various frequency components. The data were classified under two scenarios of EMF exposure: 'high wind' and 'low wind' conditions. RESULTS: The variation of the magnetic field strength was calculated between 1.13 and 1.42% (WPM). Measurements indicate that the intensity of the emitted magnetic field at the base of the wind turbines, in both high and low wind conditions, was relatively low (mean = 0.146 μT), while decreasing rapidly with increasing distance and reaching background values 6 m from the base. CONCLUSION: The results of the present study indicate that EMF levels are similar or even lower compared to those in urban areas and well below the national and international safety limits. CI - © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. FAU - Aris, A AU - Aris A AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. FAU - Yiannis, K AU - Yiannis K AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. AD - Department of BioMedical Sciences, University of West Attica, Athens, Greece. FAU - Charilaos, T AU - Charilaos T AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. FAU - Alkhorayef, M AU - Alkhorayef M AD - Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, Saudi Arabia. FAU - Sulieman, A AU - Sulieman A AD - Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Saudi Arabia. FAU - Ioannis, T AU - Ioannis T AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. FAU - Kiki, T AU - Kiki T AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. FAU - Constantin, K AU - Constantin K AD - Department of Medical Physics, Medical School, University of Thessaly, Larissa, Greece. LA - eng PT - Journal Article PL - England TA - Radiat Prot Dosimetry JT - Radiation protection dosimetry JID - 8109958 SB - IM MH - *Electromagnetic Fields/adverse effects MH - *Environmental Exposure MH - Greece MH - Humans EDAT- 2020/05/16 06:00 MHDA- 2021/06/24 06:00 CRDT- 2020/05/16 06:00 PHST- 2020/02/05 00:00 [received] PHST- 2020/03/09 00:00 [revised] PHST- 2020/03/25 00:00 [accepted] PHST- 2020/05/16 06:00 [pubmed] PHST- 2021/06/24 06:00 [medline] PHST- 2020/05/16 06:00 [entrez] AID - 5837335 [pii] AID - 10.1093/rpd/ncaa053 [doi] PST - ppublish SO - Radiat Prot Dosimetry. 2020 Jul 17;189(3):395-400. doi: 10.1093/rpd/ncaa053. PMID- 33845838 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210416 IS - 1754-9493 (Print) IS - 1754-9493 (Electronic) IS - 1754-9493 (Linking) VI - 15 IP - 1 DP - 2021 Apr 12 TI - Pan-dent-emic: safety considerations for dental surgery in the era of COVID-19. PG - 16 LID - 10.1186/s13037-021-00289-3 [doi] LID - 16 AB - The global coronavirus disease 2019 (COVID-19) pandemic spread has seized the entire world and has created extensive health concerns in the general population. Despite various efforts to prevent the pandemic spread, the flare-up of this disease is still soaring due to the community spread in every area. The droplet spread from the afflicted is of the highest concern because of its rapid spread to uninfected individuals. Dental treatments have to be planned and carried out with extreme caution and dental personnel should take extreme care and follow meticulous guidelines when treating an individual with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. This article highlights the clinical picture of COVID-19 (coronavirus diseases 2019) and presents a summary of precautionary and prophylactic measures in preventing the cross-infection and the nosocomial spread of the infection in a dental setting. FAU - Mascarenhas, Roma Enette AU - Mascarenhas RE AUID- ORCID: 0000-0003-3407-8685 AD - Department of Conservative Dentistry and Endodontics, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, 575001, India. FAU - Pralhad, Swati AU - Pralhad S AUID- ORCID: 0000-0003-4512-0252 AD - Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, 575001, India. FAU - Manaktala, Nidhi AU - Manaktala N AUID- ORCID: 0000-0001-9084-3383 AD - Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Mangalore, Karnataka, 575001, India. manaktala.nidhi@manipal.edu. LA - eng PT - Journal Article PT - Review DEP - 20210412 PL - England TA - Patient Saf Surg JT - Patient safety in surgery JID - 101319176 PMC - PMC8040369 OTO - NOTNLM OT - COVID-19 OT - Coronavirus OT - Dentistry OT - SARS- COV 2 COIS- The authors of this case report declare that they have no competing interests. EDAT- 2021/04/14 06:00 MHDA- 2021/04/14 06:01 PMCR- 2021/04/12 CRDT- 2021/04/13 05:35 PHST- 2020/12/08 00:00 [received] PHST- 2021/03/22 00:00 [accepted] PHST- 2021/04/13 05:35 [entrez] PHST- 2021/04/14 06:00 [pubmed] PHST- 2021/04/14 06:01 [medline] PHST- 2021/04/12 00:00 [pmc-release] AID - 10.1186/s13037-021-00289-3 [pii] AID - 289 [pii] AID - 10.1186/s13037-021-00289-3 [doi] PST - epublish SO - Patient Saf Surg. 2021 Apr 12;15(1):16. doi: 10.1186/s13037-021-00289-3. PMID- 31249673 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20250103 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 8 DP - 2019 TI - Medicines in pregnancy. LID - F1000 Faculty Rev-911 [pii] LID - 10.12688/f1000research.17535.1 [doi] AB - Medicine use in pregnancy is extremely common, but there are significant knowledge gaps surrounding the safety, dosage and long-term effects of drugs used. Pregnant women have been purposively excluded from clinical trials of the majority of treatments for conditions that may occur concurrently with pregnancy. There is minimal information on the pharmacokinetics of many existing treatments and no systematic capture of long-term outcome data to help inform choices. Treatments commonly used in pregnancy are thus often old and untested, not optimised in dose, and prescribed off-label without adequate safety information. In addition, there has been a staggering lack of investment in drug development for obstetric conditions for decades. This is a major public health concern, and pregnancy complications are the leading cause of mortality in children under five years old globally, and health in pregnancy is a major determinant of women's long-term health and wellbeing. There is an acute need for adequate investment and legislation to boost inclusion of pregnant women in clinical studies, capture high-quality information on medication use in pregnancy in general, and encourage new medicinal product development for obstetric conditions. FAU - Stock, Sarah Je AU - Stock SJ AUID- ORCID: 0000-0003-4308-856X AD - Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Nine Edinburgh BioQuarter, 9 Little France Road, Edinburgh, EH16 4UX, UK. FAU - Norman, Jane E AU - Norman JE AD - MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh BioQuarter, Edinburgh, EH16 4SA, UK. AD - Faculty of Health Sciences, University of Bristol, 5 Tyndall Avenue, Bristol, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - MR/N022556/1/MRC_/Medical Research Council/United Kingdom GR - 209560/Z/17/Z/WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20190620 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Child MH - Child, Preschool MH - *Delivery of Health Care MH - *Drug Therapy MH - Female MH - Humans MH - Pregnancy MH - *Pregnant People PMC - PMC6587138 OTO - NOTNLM OT - Child Health OT - Maternal Health OT - Medicines OT - Newborn Health OT - Pharmacokinetics OT - Pharmacovigilance OT - Pregnancy OT - Public Health COIS- No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed. EDAT- 2019/06/30 06:00 MHDA- 2020/06/02 06:00 PMCR- 2019/06/20 CRDT- 2019/06/29 06:00 PHST- 2019/06/18 00:00 [accepted] PHST- 2019/06/29 06:00 [entrez] PHST- 2019/06/30 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2019/06/20 00:00 [pmc-release] AID - F1000 Faculty Rev-911 [pii] AID - 10.12688/f1000research.17535.1 [doi] PST - epublish SO - F1000Res. 2019 Jun 20;8:F1000 Faculty Rev-911. doi: 10.12688/f1000research.17535.1. eCollection 2019. PMID- 32357742 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200504 IS - 1089-7623 (Electronic) IS - 0034-6748 (Linking) VI - 91 IP - 4 DP - 2020 Apr 1 TI - A novel instrument for investigating the dynamic microstructure evolution of high temperature service materials up to 1150 °C in scanning electron microscope. PG - 043704 LID - 10.1063/1.5142807 [doi] AB - High temperature materials usually serve under extreme conditions. In order to ensure the safety and reliability of industrial application, it is very significant to clarify the microstructural evolution and mechanical properties at high temperature. The in situ experiment combining mechanical tensile testing and heating in the scanning electron microscope (SEM) is a feasible method to study the relationship between the microstructure, mechanical properties, and temperature. However, it was challenging to acquire images of high quality when the temperature exceeded 800 °C due to the effect of thermal electrons and the instability of loading conditions at high temperature. In this study, a mini-tensile apparatus was devised and installed in an ordinary SEM, which can achieve a stable loading of 0-2200 N and obtain high quality images in the temperature range of 1150 °C. A highly efficient heat source with multi-layer thermal insulation was designed to prevent the other parts of the apparatus from being affected by high temperature. A symmetrical tensile structure was developed to ensure that the region of interest was always within the field of view of the microscope during testing. Thermal electrons were suppressed to ensure that the sample can be clearly distinguished at 1150 °C. In order to ensure the testing reliability, standard carbon steel was used to calibrate the instrument. Finally, a Ni-based single crystal superalloy, as an example, was tested using this in situ tensile testing system at 1150 °C to verify the main functions and reliability of the apparatus. FAU - Ma, Jinyao AU - Ma J AD - Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China. FAU - Lu, Junxia AU - Lu J AD - Institute of Laser Engineering, Beijing University of Technology, Beijing 100124, China. FAU - Tang, Liang AU - Tang L AD - Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China. FAU - Wang, Jin AU - Wang J AD - School of Materials Science and Engineering, Zhejiang University, 310027 Hangzhou, China. FAU - Sang, Lijun AU - Sang L AD - Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China. FAU - Zhang, Yuefei AU - Zhang Y AD - Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China. FAU - Zhang, Ze AU - Zhang Z AD - Institute of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100124, China. LA - eng PT - Journal Article PL - United States TA - Rev Sci Instrum JT - The Review of scientific instruments JID - 0405571 SB - IM EDAT- 2020/05/03 06:00 MHDA- 2020/05/03 06:01 CRDT- 2020/05/03 06:00 PHST- 2020/05/03 06:00 [entrez] PHST- 2020/05/03 06:00 [pubmed] PHST- 2020/05/03 06:01 [medline] AID - 10.1063/1.5142807 [doi] PST - ppublish SO - Rev Sci Instrum. 2020 Apr 1;91(4):043704. doi: 10.1063/1.5142807. PMID- 30035849 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) VI - 14 IP - 34 DP - 2018 Aug TI - Flexible, Flame-Resistant, and Dendrite-Impermeable Gel-Polymer Electrolyte for Li-O(2) /Air Batteries Workable Under Hurdle Conditions. PG - e1801798 LID - 10.1002/smll.201801798 [doi] AB - Gel-polymer electrolytes are considered as a promising candidate for replacing the liquid electrolytes to address the safety concerns in Li-O(2) /air batteries. In this work, by taking advantage of the hydrogen bond between thermoplastic polyurethane and aerogel SiO(2) in gel polymer, a highly crosslinked quasi-solid electrolyte (FST-GPE) with multifeatures of high ionic conductivity, high mechanical flexibility, favorable flame resistance, and excellent Li dendrite impermeability is developed. The resulting gel-polymer Li-O(2) /air batteries possess high reaction kinetics and stabilities due to the unique electrode-electrolyte interface and fast O(2) diffusion in cathode, which can achieve up to 250 discharge-charge cycles (over 1000 h) in oxygen gas. Under ambient air atmosphere, excellent performances are observed for coin-type cells over 20 days and for prototype cells working under extreme bending conditions. Moreover, the FST-GPE electrolyte also exhibits durability to protect against fire, dendritic Li, and H(2) O attack, demonstrating great potential for the design of practical Li-O(2) /air batteries. CI - © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Zou, Xiaohong AU - Zou X AD - Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing, 210009, China. FAU - Lu, Qian AU - Lu Q AD - Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing, 210009, China. FAU - Zhong, Yijun AU - Zhong Y AD - WA School of Mines: Minerals, Energy and Chemical Engineering (WASM-MECE), Curtin University, Perth, WA, 6845, Australia. FAU - Liao, Kaiming AU - Liao K AD - Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing, 210009, China. AD - School of Energy Science and Engineering, Nanjing Tech University, Nanjing, 210009, China. FAU - Zhou, Wei AU - Zhou W AD - Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing, 210009, China. FAU - Shao, Zongping AU - Shao Z AUID- ORCID: 0000-0002-4538-4218 AD - Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, No. 5 Xin Mofan Road, Nanjing, 210009, China. AD - WA School of Mines: Minerals, Energy and Chemical Engineering (WASM-MECE), Curtin University, Perth, WA, 6845, Australia. LA - eng PT - Journal Article DEP - 20180723 PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 OTO - NOTNLM OT - Li dendrites OT - Li-O2/air batteries OT - flame resistance OT - flexible OT - gel-polymer electrolytes EDAT- 2018/07/24 06:00 MHDA- 2018/07/24 06:01 CRDT- 2018/07/24 06:00 PHST- 2018/05/10 00:00 [received] PHST- 2018/06/04 00:00 [revised] PHST- 2018/07/24 06:00 [pubmed] PHST- 2018/07/24 06:01 [medline] PHST- 2018/07/24 06:00 [entrez] AID - 10.1002/smll.201801798 [doi] PST - ppublish SO - Small. 2018 Aug;14(34):e1801798. doi: 10.1002/smll.201801798. Epub 2018 Jul 23. PMID- 21703129 OWN - NLM STAT- MEDLINE DCOM- 20111206 LR - 20240109 IS - 2242-3982 (Electronic) IS - 1239-9736 (Linking) VI - 70 IP - 3 DP - 2011 Jun TI - Climate change health assessment: a novel approach for Alaska Native communities. PG - 266-73 AB - OBJECTIVES: Develop a process for assessing climate change impacts on public health that identifies climate-health vulnerabilities and mechanisms and encourages adaptation. STUDY DESIGN: Multi-stakeholder, participatory, qualitative research. METHODS: A Climate Change Health Assessment (CCHA) was developed that involved 4 steps: (1) scoping to describe local conditions and engage stakeholders; (2) surveying to collect descriptive and quantitative data; (3) analysis to evaluate the data; and (4) planning to communicate findings and explore appropriate actions with community members. The health effects related to extreme weather, thinning ice, erosion, flooding, thawing permafrost and changing conditions of water and food resources were considered. RESULTS: The CCHA process was developed and performed in north-west Arctic villages. Refinement of the process took place in Point Hope, a coastal Inupiat village that practices whaling and a variety of other traditional subsistence harvest practices. Local observers identified climate change impacts that resulted in damaged health infrastructure, compromised food and water security and increased risk of injury. Priority health issues included thawing traditional ice cellars, diminished quality of the community water source and increased safety issues related to sea ice change. The CCHA increased awareness about health vulnerability and encouraged informed planning and decision-making. CONCLUSION: A community-scale assessment process guided by observation-based data can identify climate health impacts, raise awareness and encourage adaptive actions, thereby improving the response capacity of communities vulnerable to climate change. FAU - Brubaker, Michael Y AU - Brubaker MY AD - Center for Climate and Health, Alaska Native Tribal Health Consortium, Anchorage, Alaska 99507, USA. mbrubaker@anthc.org FAU - Bell, Jacob N AU - Bell JN FAU - Berner, James E AU - Berner JE FAU - Warren, John A AU - Warren JA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20110623 PL - United States TA - Int J Circumpolar Health JT - International journal of circumpolar health JID - 9713056 SB - IM CIN - Int J Circumpolar Health. 2011;70(5):447-9. doi: 10.3402/ijch.v70i5.17856. PMID: 22208994 MH - Alaska MH - *Climate Change MH - *Health Status MH - Health Surveys MH - Humans MH - *Inuit EDAT- 2011/06/28 06:00 MHDA- 2011/12/13 00:00 CRDT- 2011/06/28 06:00 PHST- 2011/06/28 06:00 [entrez] PHST- 2011/06/28 06:00 [pubmed] PHST- 2011/12/13 00:00 [medline] AID - 1104 [pii] AID - 10.3402/ijch.v70i3.17820 [doi] PST - ppublish SO - Int J Circumpolar Health. 2011 Jun;70(3):266-73. doi: 10.3402/ijch.v70i3.17820. Epub 2011 Jun 23. PMID- 34464078 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210916 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 13 IP - 36 DP - 2021 Sep 15 TI - Magnetohydrodynamic Control of Interfacial Degradation in Lithium-Ion Batteries for Fast Charging Applications. PG - 43606-43614 LID - 10.1021/acsami.1c10788 [doi] AB - Interfacial anodic degradation in graphitic materials under fast charging conditions causes severe performance loss and safety hazard in lithium ion batteries. We present a novel method for minimizing the growth of these aging mechanism by application of an external magnetic field. Under magnetic field, paramagnetic lithium ions experience a magnetohydrodynamic force, which rotates the perpendicularly diffusing species and homogenizes the ionic transport. This phenomenon minimizes the overpotential hotspots at the anode/separator interface, consequently reducing SEI growth, lithium plating, and interfacial fracture. In situ electrochemical measurements indicate an improvement in capacity for lithium cobalt oxide/graphite pouch cell (20 mAh) charged from 1-5 C under an applied field of 1.8 kG, with a maximum capacity gain of 22% at 5C. Post-mortem FE-SEM and EDS mapping shows that samples charged with magnetic field have a reduced lithium deposition at 3C and a complete suppression of interfacial fracture at 5C. At 5C, a 24% reduction in the lithium content is observed by performing XPS on the anodic interfacial film. Finally, fast charging performance under variable magnetic field strengths indicate a saturation behavior in capacity at high fields (>2 kG), thereby limiting the field and consequent energy requirements to obtain maximum capacity gain under extreme conditions. FAU - Sarkar, Abhishek AU - Sarkar A AUID- ORCID: 0000-0001-5389-6558 AD - Ames Laboratory, US Department of Energy, Ames, Iowa 50011, United States. FAU - Shrotriya, Pranav AU - Shrotriya P AUID- ORCID: 0000-0001-9263-4892 AD - Department of Mechanical Engineering, Iowa State University, Ames, Iowa 50011, United States. FAU - Nlebedim, Ikenna C AU - Nlebedim IC AUID- ORCID: 0000-0002-0045-4585 AD - Ames Laboratory, US Department of Energy, Ames, Iowa 50011, United States. LA - eng PT - Journal Article DEP - 20210831 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 SB - IM OTO - NOTNLM OT - electromagnetism OT - fast charging OT - film deposition OT - lithium-ion battery OT - magneto-electrochemical OT - magnetohydrodynamic force EDAT- 2021/09/01 06:00 MHDA- 2021/09/01 06:01 CRDT- 2021/08/31 17:09 PHST- 2021/09/01 06:00 [pubmed] PHST- 2021/09/01 06:01 [medline] PHST- 2021/08/31 17:09 [entrez] AID - 10.1021/acsami.1c10788 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2021 Sep 15;13(36):43606-43614. doi: 10.1021/acsami.1c10788. Epub 2021 Aug 31. PMID- 3591646 OWN - NLM STAT- MEDLINE DCOM- 19870626 LR - 20121115 IS - 0002-8894 (Print) IS - 0002-8894 (Linking) VI - 48 IP - 4 DP - 1987 Apr TI - Penetration of methyl isocyanate through organic vapor and acid gas respirator cartridges. PG - 315-23 AB - Methyl isocyanate (MIC) is a volatile, toxic chemical [Threshold Limit Value (TLV) = 0.02 ppm] used to manufacture carbamate pesticides. The principal manufacturer of MIC is Union Carbide, and the site of production is Institute, West Virginia. In light of the December 1984 Bhopal, India disaster and possible safety problems at the Institute facility, NIOSH conducted this research as a basis upon which to recommend protective equipment that might be used in an emergency situation where extremely high MIC concentrations might be encountered. Both protective clothing and respirators were evaluated. In particular, NIOSH studied air-purifying respirators in order to assess their effectiveness against MIC vapor penetration. NIOSH does not recommend any air purifying respirator for MIC because of its high toxicity and lack of warning properties and because no effective end of service life indicator currently is available for MIC. This report addresses only MIC penetration through air-purifying cartridges at challenge concentrations designed to simulate emergency escape conditions. Another report addresses the protective clothing issue. The results presented are for two different manufacturers' organic vapor (OV) and acid gas cartridges. Penetration tests were conducted at three or four MIC challenge concentrations and at three different humidity conditions. In general, breakthrough times (1% of challenge concentration) were very short (less than 20 min). Also, high relative humidity was found to decrease the breakthrough time of MIC. FAU - Moyer, E S AU - Moyer ES FAU - Berardinelli, S P AU - Berardinelli SP LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Am Ind Hyg Assoc J JT - American Industrial Hygiene Association journal JID - 0371160 RN - 0 (Cyanates) RN - 0 (Isocyanates) RN - C588JJ4BV9 (methyl isocyanate) SB - IM MH - *Cyanates MH - *Isocyanates MH - Kinetics MH - Permeability MH - Protective Devices/*standards MH - Quality Control MH - Respiratory Protective Devices/*standards EDAT- 1987/04/01 00:00 MHDA- 1987/04/01 00:01 CRDT- 1987/04/01 00:00 PHST- 1987/04/01 00:00 [pubmed] PHST- 1987/04/01 00:01 [medline] PHST- 1987/04/01 00:00 [entrez] AID - 10.1080/15298668791384823 [doi] PST - ppublish SO - Am Ind Hyg Assoc J. 1987 Apr;48(4):315-23. doi: 10.1080/15298668791384823. PMID- 33096495 OWN - NLM STAT- MEDLINE DCOM- 20201208 LR - 20201214 IS - 1532-8511 (Electronic) IS - 1052-3057 (Linking) VI - 29 IP - 12 DP - 2020 Dec TI - Embolization with Stent-Assisted Technique for Wide-Necked Extremely Small Intracranial Aneurysm with Diameter no more than 2 mm. PG - 105388 LID - S1052-3057(20)30806-5 [pii] LID - 10.1016/j.jstrokecerebrovasdis.2020.105388 [doi] AB - OBJECTIVE: To investigate the safety and efficacy of embolization with stent-assisted technique for wide-necked extremely small intracranial aneurysms (ESIAs) with diameter no more than 2 mm. METHODS: From May 2015 through January 2019, 20 wide-necked ESIAs in 19 patients (6 males and 13 females, aged from 38 to 72 years old, average 59 years old) were embolized with stent-assisted technique. All these patients had a total of 29 aneurysms, 7 patients had multiple aneurysms and 1 patient had 2 ESIAs. 12 patients (63.2%) presented with subarachnoid hemorrhage (SAH), 9 of them have a culprit ESIA. The angiographic results before and after operation, procedural complications, and clinical condition with Hunt and Hess grade (H-H) and Fisher grade, as well as Glasgow outcome scale (GOS) at discharge were assessed. Follow-up results were evaluated by computer tomograph angiography (CTA) or digital subtract angiography (DSA). RESULTS: The mean diameter of aneurysm neck was 1.68 ± 0.21 mm. Complete occlusion with Raymond grade I was achieved in 18 aneurysms (90.9%), 2 aneurysms were subtotal embolization with Raymond grade II (9.1%). All patients were treated with coil embolization with stent-assist technique successfully and all the stents were placed accurately and function well during the procedure. There is no rupture of aneurysm during operation, no coil protrusion to the distal blood vessel, and no cerebral infarction as well. When discharged, all patients recovered well. The follow-up results showed that only one patients with recurrence of aneurysm 27 months after embolization. CONCLUSION: Embolization with stent-assisted technique for wide-necked ESIAs is safe and effective. However, the follow-up is not long enough in our study and a larger sample size are needed to obtain the long-term efficacy. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - Tian, Qi AU - Tian Q AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. FAU - Dong, Wei AU - Dong W AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. FAU - Xu, Zhou AU - Xu Z AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. FAU - Wang, Junmin AU - Wang J AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. FAU - Chen, Qianxue AU - Chen Q AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. Electronic address: chenqx666@whu.edu.cn. FAU - Li, Mingchang AU - Li M AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Jie Fang Road 238, Wuhan, Hubei, 430060, China. Electronic address: mingcli@whu.edu.cn. LA - eng PT - Journal Article DEP - 20201020 PL - United States TA - J Stroke Cerebrovasc Dis JT - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JID - 9111633 SB - IM MH - Adult MH - Aged MH - Aneurysm, Ruptured/diagnostic imaging/*therapy MH - Embolization, Therapeutic/adverse effects/*instrumentation MH - Endovascular Procedures/adverse effects/*instrumentation MH - Female MH - Humans MH - Intracranial Aneurysm/diagnostic imaging/*therapy MH - Male MH - Middle Aged MH - Recurrence MH - Retrospective Studies MH - *Stents MH - Subarachnoid Hemorrhage/diagnostic imaging/*therapy MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Coil embolization OT - Endovascular therapy OT - Extremely small intracranial aneurysm OT - Stent EDAT- 2020/10/24 06:00 MHDA- 2020/12/15 06:00 CRDT- 2020/10/23 20:19 PHST- 2020/06/28 00:00 [received] PHST- 2020/08/25 00:00 [revised] PHST- 2020/10/04 00:00 [accepted] PHST- 2020/10/24 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2020/10/23 20:19 [entrez] AID - S1052-3057(20)30806-5 [pii] AID - 10.1016/j.jstrokecerebrovasdis.2020.105388 [doi] PST - ppublish SO - J Stroke Cerebrovasc Dis. 2020 Dec;29(12):105388. doi: 10.1016/j.jstrokecerebrovasdis.2020.105388. Epub 2020 Oct 20. PMID- 21217865 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20211020 IS - 1337-9569 (Electronic) IS - 1337-6853 (Print) IS - 1337-6853 (Linking) VI - 3 IP - 1 DP - 2010 Mar TI - Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats. PG - 3-14 LID - 10.2478/v10102-010-0005-3 [doi] AB - Cataract, the opacification of eye lens, is the leading cause of blindness worldwide. At present, the only remedy is surgical removal of the cataractous lens and substitution with a lens made of synthetic polymers. However, besides significant costs of operation and possible complications, an artificial lens just does not have the overall optical qualities of a normal one. Hence it remains a significant public health problem, and biochemical solutions or pharmacological interventions that will maintain the transparency of the lens are highly required. Naturally, there is a persistent demand for suitable biological models. The ocular lens would appear to be an ideal organ for maintaining culture conditions because of lacking blood vessels and nerves. The lens in vivo obtains its nutrients and eliminates waste products via diffusion with the surrounding fluids. Lens opacification observed in vivo can be mimicked in vitro by addition of the cataractogenic agent sodium selenite (Na(2)SeO(3)) to the culture medium. Moreover, since an overdose of sodium selenite induces also cataract in young rats, it became an extremely rapid and convenient model of nuclear cataract in vivo. The main focus of this review will be on selenium (Se) and its salt sodium selenite, their toxicological characteristics and safety data in relevance of modelling cataractogenesis, either under in vivo or in vitro conditions. The studies revealing the mechanisms of lens opacification induced by selenite are highlighted, the representatives from screening for potential anti-cataract agents are listed. FAU - Kyselova, Zuzana AU - Kyselova Z AD - Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia. LA - eng PT - Journal Article DEP - 20100329 PL - Slovakia TA - Interdiscip Toxicol JT - Interdisciplinary toxicology JID - 101528175 PMC - PMC2984119 OTO - NOTNLM OT - crystallins OT - eye lens OT - nuclear cataract OT - rats OT - sodium selenite EDAT- 2011/01/11 06:00 MHDA- 2011/01/11 06:01 PMCR- 2010/03/01 CRDT- 2011/01/11 06:00 PHST- 2010/01/15 00:00 [received] PHST- 2010/02/12 00:00 [revised] PHST- 2010/02/15 00:00 [accepted] PHST- 2011/01/11 06:00 [entrez] PHST- 2011/01/11 06:00 [pubmed] PHST- 2011/01/11 06:01 [medline] PHST- 2010/03/01 00:00 [pmc-release] AID - ITX-3-003 [pii] AID - 10.2478/v10102-010-0005-3 [doi] PST - ppublish SO - Interdiscip Toxicol. 2010 Mar;3(1):3-14. doi: 10.2478/v10102-010-0005-3. Epub 2010 Mar 29. PMID- 36670754 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240911 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 13 IP - 2 DP - 2023 Jan 6 TI - Mobile Zoos and Other Itinerant Animal Handling Events: Current Status and Recommendations for Future Policies. LID - 10.3390/ani13020214 [doi] LID - 214 AB - Mobile zoos are events in which non-domesticated (exotic) and domesticated species are transported to venues such as schools, hospitals, parties, and community centres, for the purposes of education, entertainment, or social and therapeutic assistance. We conducted literature searches and surveyed related government agencies regarding existing provisions within laws and policies, number of mobile zoos, and formal guidance issued concerning operation of such events in 74 countries or regions. We also examined governmental and non-governmental guidance standards for mobile zoos, as well as websites for mobile zoo operations, assessed promotional or educational materials for scientific accuracy, and recorded the diversity of species in use. We used the EMODE (Easy, Moderate, Difficult, or Extreme) algorithm, to evaluate identified species associated with mobile zoos for their suitability for keeping. We recorded 14 areas of concern regarding animal biology and public health and safety, and 8 areas of false and misleading content in promotional or educational materials. We identified at least 341 species used for mobile zoos. Mobile zoos are largely unregulated, unmonitored, and uncontrolled, and appear to be increasing. Issues regarding poor animal welfare, public health and safety, and education raise several serious concerns. Using the precautionary principle when empirical evidence was not available, we advise that exotic species should not be used for mobile zoos and similar itinerant events. FAU - Warwick, Clifford AU - Warwick C AD - Emergent Disease Foundation, 71-75 Shelton Street, Covent Garden, London WC2H 9JQ, UK. FAU - Pilny, Anthony AU - Pilny A AD - Arizona Exotic Animal Hospital, 2340 E Beardsley Road Ste 100, Phoenix, AZ 85024, USA. FAU - Steedman, Catrina AU - Steedman C AUID- ORCID: 0000-0003-2809-1445 AD - Emergent Disease Foundation, 71-75 Shelton Street, Covent Garden, London WC2H 9JQ, UK. FAU - Howell, Tiffani AU - Howell T AUID- ORCID: 0000-0002-4932-5792 AD - School of Psychology and Public Health, La Trobe University, P.O. Box 199, Bendigo, VIC 3552, Australia. FAU - Martínez-Silvestre, Albert AU - Martínez-Silvestre A AUID- ORCID: 0000-0003-3382-6784 AD - Catalonian Reptiles and Amphibians Rescue Centre (CRARC), 08783 Masquefa, Spain. FAU - Cadenas, Vanessa AU - Cadenas V AD - Animal Protection Biodiversity & Environment Section, Government of Catalonia, 43004 Tarragona, Spain. FAU - Grant, Rachel AU - Grant R AD - School of Applied Sciences, London South Bank University, 103 Borough Rd, London SE1 0AA, UK. LA - eng GR - n/a/World Animal Protection Canada/ GR - n/a/ZooCheck Canada/ PT - Journal Article DEP - 20230106 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC9854913 OTO - NOTNLM OT - animal assisted interventions OT - animal welfare OT - injury OT - legislation OT - mobile live animal programs OT - mobile zoos OT - one-health OT - precautionary principle OT - public health OT - safety COIS- The authors declare no conflict of interest. EDAT- 2023/01/22 06:00 MHDA- 2023/01/22 06:01 PMCR- 2023/01/06 CRDT- 2023/01/21 01:02 PHST- 2022/11/07 00:00 [received] PHST- 2022/12/07 00:00 [revised] PHST- 2022/12/25 00:00 [accepted] PHST- 2023/01/21 01:02 [entrez] PHST- 2023/01/22 06:00 [pubmed] PHST- 2023/01/22 06:01 [medline] PHST- 2023/01/06 00:00 [pmc-release] AID - ani13020214 [pii] AID - animals-13-00214 [pii] AID - 10.3390/ani13020214 [doi] PST - epublish SO - Animals (Basel). 2023 Jan 6;13(2):214. doi: 10.3390/ani13020214. PMID- 32446022 OWN - NLM STAT- MEDLINE DCOM- 20210713 LR - 20210713 IS - 1532-866X (Electronic) IS - 0049-0172 (Linking) VI - 50 IP - 4 DP - 2020 Aug TI - Safety of TNF inhibitors in rheumatic disease in case of NAFLD and cirrhosis. PG - 544-548 LID - S0049-0172(20)30087-1 [pii] LID - 10.1016/j.semarthrit.2020.03.013 [doi] AB - The management of inflammatory rheumatic diseases has substantially changed in recent years, as has the profile of patients. The advent of biotherapies has been a revolution in rheumatology and the impact of co-morbidities in the management of these patients is now becoming increasingly important. Metabolic syndrome (MetS) is one of the most frequent comorbidities, and hepatic complications of MetS are not uncommon. MetS is responsible for Non-alcoholic fatty liver disease (NAFLD), characterized by excessive hepatic fat accumulation. In extreme cases, progression to cirrhosis is possible. NAFLD ranks among the top three indications for liver transplantation. We review available data on the safety, especially the risk of infections, of TNF inhibitors (TNFi) in case of NAFLD and in case of liver cirrhosis, in patients with rheumatic disease. In cases of NAFLD without severe fibrosis, available data are reassuring and tend to show a beneficial effect of TNFi on hepatic tissue. In case of cirrhosis, data are conflicting. Further large, well-designed studies are needed to explore this specific issue. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - Verhoeven, Frank AU - Verhoeven F AD - Department of Rheumatology, CHRU Besançon - France; EA 4267 "PEPITE", FHU Increase, Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. Electronic address: fverhoeven@chu-besancon.fr. FAU - Weil-Verhoeven, Delphine AU - Weil-Verhoeven D AD - Department of Hepatology, CHRU Besançon, France; EA 4266 "Pathogens and inflammation, EPILAB", Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. FAU - Prati, Clément AU - Prati C AD - Department of Rheumatology, CHRU Besançon - France; EA 4267 "PEPITE", FHU Increase, Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. FAU - Martino, Vincent Di AU - Martino VD AD - Department of Hepatology, CHRU Besançon, France; EA 4266 "Pathogens and inflammation, EPILAB", Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. FAU - Thevenot, Thierry AU - Thevenot T AD - Department of Hepatology, CHRU Besançon, France; EA 4266 "Pathogens and inflammation, EPILAB", Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. FAU - Wendling, Daniel AU - Wendling D AD - Department of Rheumatology, CHRU Besançon - France; EA 4266 "Pathogens and inflammation, EPILAB", Université Bourgogne - Franche Comte, UFR SMP, Besançon, France. LA - eng PT - Journal Article PT - Review DEP - 20200511 PL - United States TA - Semin Arthritis Rheum JT - Seminars in arthritis and rheumatism JID - 1306053 RN - 0 (Tumor Necrosis Factor Inhibitors) SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - Liver Cirrhosis/complications MH - Male MH - Middle Aged MH - Non-alcoholic Fatty Liver Disease/complications MH - Rheumatic Diseases/complications/*drug therapy MH - Tumor Necrosis Factor Inhibitors/administration & dosage/*adverse effects OTO - NOTNLM OT - Cirrhosis OT - NAFLD OT - Safety OT - TNF inhibitor COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/05/24 06:00 MHDA- 2021/07/14 06:00 CRDT- 2020/05/24 06:00 PHST- 2019/10/15 00:00 [received] PHST- 2020/03/06 00:00 [revised] PHST- 2020/03/23 00:00 [accepted] PHST- 2020/05/24 06:00 [pubmed] PHST- 2021/07/14 06:00 [medline] PHST- 2020/05/24 06:00 [entrez] AID - S0049-0172(20)30087-1 [pii] AID - 10.1016/j.semarthrit.2020.03.013 [doi] PST - ppublish SO - Semin Arthritis Rheum. 2020 Aug;50(4):544-548. doi: 10.1016/j.semarthrit.2020.03.013. Epub 2020 May 11. PMID- 39209990 OWN - NLM STAT- MEDLINE DCOM- 20240829 LR - 20240903 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Aug 29 TI - Ultralow radiant exposure of a short-pulsed laser to disrupt melanosomes with localized thermal damage through a turbid medium. PG - 20112 LID - 10.1038/s41598-024-70807-7 [doi] LID - 20112 AB - Short-pulsed lasers can treat dermal pigmented lesions through selective photothermolysis. The irradiated light experiences multiple scattering by the skin and is absorbed by abnormal melanosomes as well as by normal blood vessels above the target. Because the fluence is extremely high, the absorbed light can cause thermal damage to the adjacent tissue components, leading to complications. To minimize radiant exposure and reduce the risk of burns, a model of the melanosome-disruption threshold fluence (MDTF) has been developed that accounts for the light-propagation efficiency in the skin. However, the light-propagation efficiency is attenuated because of multiple scattering, which limits the extent to which the radiant exposure required for treatment can be reduced. Here, this study demonstrates the principle of melanosome disruption with localized thermal damage through a turbid medium by ultralow radiant exposure of a short-pulsed laser. The MDTF model was combined with a wavefront-shaping technique to design an irradiation condition that can increase the light-propagation efficiency to the target. Under this irradiation condition, melanosomes were disrupted at a radiant exposure 25 times lower than the minimal value used in conventional laser treatments. Furthermore, almost no thermal damage to the skin was confirmed through a numerical simulation. These experimental and numerical results show the potential for noninvasive melanosome disruption and may lead to the improvement of the safety of short-pulsed laser treatment. CI - © 2024. The Author(s). FAU - Shimojo, Yu AU - Shimojo Y AD - Derpartment of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno, Osaka, 545-8585, Japan. x22800k@omu.ac.jp. AD - Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. x22800k@omu.ac.jp. AD - Research Fellow of Japan Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda, Tokyo, 102-0083, Japan. x22800k@omu.ac.jp. FAU - Nishimura, Takahiro AU - Nishimura T AD - Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. nishimura-t@see.eng.osaka-u.ac.jp. FAU - Tsuruta, Daisuke AU - Tsuruta D AD - Derpartment of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno, Osaka, 545-8585, Japan. FAU - Ozawa, Toshiyuki AU - Ozawa T AD - Derpartment of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahimachi, Abeno, Osaka, 545-8585, Japan. LA - eng GR - 23KJ1825/Japan Society for the Promotion of Science/ GR - 23K04613/Japan Society for the Promotion of Science/ GR - JPMJAX21K7/Japan Science and Technology Agency/ PT - Journal Article DEP - 20240829 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - *Melanosomes/metabolism/radiation effects MH - Skin/radiation effects/metabolism MH - Animals MH - Lasers/adverse effects MH - Humans PMC - PMC11362287 COIS- The authors declare no competing interests. EDAT- 2024/08/31 09:47 MHDA- 2024/08/31 09:48 PMCR- 2024/08/29 CRDT- 2024/08/29 23:26 PHST- 2024/05/16 00:00 [received] PHST- 2024/08/21 00:00 [accepted] PHST- 2024/08/31 09:48 [medline] PHST- 2024/08/31 09:47 [pubmed] PHST- 2024/08/29 23:26 [entrez] PHST- 2024/08/29 00:00 [pmc-release] AID - 10.1038/s41598-024-70807-7 [pii] AID - 70807 [pii] AID - 10.1038/s41598-024-70807-7 [doi] PST - epublish SO - Sci Rep. 2024 Aug 29;14(1):20112. doi: 10.1038/s41598-024-70807-7. PMID- 32149064 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 2307-8960 (Print) IS - 2307-8960 (Electronic) IS - 2307-8960 (Linking) VI - 8 IP - 4 DP - 2020 Feb 26 TI - Using Materialise's interactive medical image control system to reconstruct a model of a patient with rectal cancer and situs inversus totalis: A case report. PG - 806-814 LID - 10.12998/wjcc.v8.i4.806 [doi] AB - BACKGROUND: Situs inversus totalis (SIT) is a rare congenital anomaly that refers to a completely reversed location of abdominal and thoracic organs. An extremely small number of patients with this condition, especially those with rectal neoplasms, have been reported. Surgery in these patients is technically challenging. Therefore, we reconstructed a three-dimensional (3D) digital model with the Materialise's interactive medical image control system (Mimics) as a guide for laparoscopic resection. CASE SUMMARY: We report the case of a 68-year-old woman with rectal neoplasms and SIT diagnosed by electronic colonoscopy biopsy and enhanced computed tomography (CT), which showed that there was a soft tissue mass protruding into the lumen in the lower rectal segment, a lesion that involved the serosal layer, multiple enlarged peripheral lymph nodes, and visceral situs abnormalities. Based on the CT images, we reconstructed a 3D model with Mimics to assist with our surgical planning. Then, we performed laparoscopy-assisted radical resection of the rectal neoplasms and total excision of the lesion. Adjuvant chemotherapy with the XELOX regimen (oxaliplatin 150 mg, D1 + Xeloda 1.0 g, Bid, D1-14) was initiated 1 mo after the operation. The patient recovered well after surgery, and her physical condition remained stable. CONCLUSION: Preoperative 3D reconstruction of the imaging results could help reduce the unknown risks during surgery caused by anatomical abnormalities and improve the perioperative safety for patients. CI - ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Chen, Tao AU - Chen T AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. drchentao@163.com. FAU - Que, Yu-Tao AU - Que YT AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Zhang, Yi-Hao AU - Zhang YH AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Long, Fei-Yu AU - Long FY AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Li, Yi AU - Li Y AD - Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Huang, Xin AU - Huang X AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Wang, Ya-Nan AU - Wang YN AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Hu, Yan-Feng AU - Hu YF AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Yu, Jiang AU - Yu J AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. FAU - Li, Guo-Xin AU - Li GX AD - Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - World J Clin Cases JT - World journal of clinical cases JID - 101618806 PMC - PMC7052548 OTO - NOTNLM OT - Case report OT - Laparoscopy OT - Rectal neoplasm OT - Situs inversus totalis OT - Three-dimensional reconstruction COIS- Conflict-of-interest statement: The authors declare that they have no conflict of interest. EDAT- 2020/03/10 06:00 MHDA- 2020/03/10 06:01 PMCR- 2020/02/26 CRDT- 2020/03/10 06:00 PHST- 2019/10/01 00:00 [received] PHST- 2019/12/11 00:00 [revised] PHST- 2019/12/14 00:00 [accepted] PHST- 2020/03/10 06:00 [entrez] PHST- 2020/03/10 06:00 [pubmed] PHST- 2020/03/10 06:01 [medline] PHST- 2020/02/26 00:00 [pmc-release] AID - 10.12998/wjcc.v8.i4.806 [doi] PST - ppublish SO - World J Clin Cases. 2020 Feb 26;8(4):806-814. doi: 10.12998/wjcc.v8.i4.806. PMID- 22086547 OWN - NLM STAT- MEDLINE DCOM- 20120914 LR - 20161125 IS - 1434-3916 (Electronic) IS - 0936-8051 (Linking) VI - 132 IP - 4 DP - 2012 Apr TI - Unexpected injury of the orthopaedic surgeon: a case report of a hammer splinter. PG - 495-8 LID - 10.1007/s00402-011-1431-1 [doi] AB - Sharps injuries have become one of the most important occupational injuries and they are common during surgery, with rates between 1.7 and 6.9% of all surgical procedures. This case report, however, revealed an extremely rare and unexpected condition, which could not be prevented by the reasonable safety precautions against injury. Closed reduction and closed intramedullary fixation was planned for the patient with humeral shaft fracture. While advancing the nail by hammering a piece of metal detached. A short time following the commencement of the procedure, the surgeon who was performing the operation felt a sudden severe pain in the neck. A radio-opaque intensity in the cervical region was detected on X-rays. There was a piece of metal from the hammer. The risk encountered in the present case comprises a condition, the prevention of which is probably impossible with the frequently utilized preventive measures against injuries. For this reason, the operating room team and in particular, the surgeon, should be careful about possible expected injuries, as well as the unexpected ones. Sharps injuries continue to be a serious concern for all healthcare workers. In some studies however, reporting of sharps injuries by healthcare workers remains a problem with reporting levels cited as low as 15% and as high as 90% (Kerr H-L, Stewart N Ann R Coll Surg Engl 91:430-432, [6]). Guo et al. pointed out the most recent sharps injuries at work, and syringe needles was by far the most important items causing injuries, followed by glass products, suture needles, and intravenous catheters. FAU - Yildirim, Ahmet Ozgur AU - Yildirim AO AD - First Clinics of Ortopedics and Traumatology, Ankara Numune Education and Research Hospital, Republic of Turkey. FAU - Katı, Yusuf Alper AU - Katı YA FAU - Oken, Ozdamar Fuad AU - Oken OF FAU - Ucaner, Ahmet AU - Ucaner A LA - eng PT - Case Reports PT - Journal Article DEP - 20111116 PL - Germany TA - Arch Orthop Trauma Surg JT - Archives of orthopaedic and trauma surgery JID - 9011043 SB - IM MH - *Equipment Failure MH - Foreign Bodies/diagnostic imaging/*etiology MH - Fracture Fixation, Intramedullary/*instrumentation MH - Humans MH - Neck Injuries/diagnostic imaging/*etiology MH - Occupational Injuries/diagnostic imaging/*etiology MH - *Orthopedics MH - Radiography MH - Surgical Instruments/*adverse effects EDAT- 2011/11/17 06:00 MHDA- 2012/09/15 06:00 CRDT- 2011/11/17 06:00 PHST- 2011/08/19 00:00 [received] PHST- 2011/11/17 06:00 [entrez] PHST- 2011/11/17 06:00 [pubmed] PHST- 2012/09/15 06:00 [medline] AID - 10.1007/s00402-011-1431-1 [doi] PST - ppublish SO - Arch Orthop Trauma Surg. 2012 Apr;132(4):495-8. doi: 10.1007/s00402-011-1431-1. Epub 2011 Nov 16. PMID- 37830911 OWN - NLM STAT- MEDLINE DCOM- 20240215 LR - 20240617 IS - 1545-9632 (Electronic) IS - 1545-9624 (Print) IS - 1545-9624 (Linking) VI - 21 IP - 1 DP - 2024 Jan TI - Risk factors for heat-related illness resulting in death or hospitalization in the oil and gas extraction industry. PG - 58-67 LID - 10.1080/15459624.2023.2268142 [doi] AB - Many oil and gas extraction (OGE) activities occur in high-heat environments, resulting in a significant risk of heat-related illness among outdoor workers in this industry. This report highlights cases of occupational heat-related illness that resulted in death and identifies common risk factors for heat-related fatalities and hospitalizations among OGE workers. Two databases maintained by the National Institute for Occupational Safety and Health (NIOSH) and the Occupational Safety and Health Administration (OSHA) were reviewed to identify heat-related fatalities, hospitalizations, and associated risk factors among OGE workers. Nine fatalities and associated risk factors were identified during 2014-2019 from NIOSH's Fatalities in Oil and Gas Extraction (FOG) Database. Risk factors identified included those commonly associated with heat-related fatalities: new workers not acclimatized to heat, inadequate heat stress training, and underlying hypertension or cardiovascular disease. Of particular note, substance use was identified as a significant risk factor as more than half of the fatalities included a positive postmortem test for amphetamines or methamphetamines. Fifty heat-related hospitalizations were identified from OSHA's Severe Injury Report Database during January 2015-May 2021. Heat stress has been and will continue to be an important cause of fatality and adverse health effects in OGE as hot outdoor working conditions become more common and extreme. More emphasis on heat stress training, acclimatization regimens, medical screening, and implementation of workplace-supportive recovery programs may reduce heat-related fatalities and injuries in this industry. FAU - Lin, Nancy W AU - Lin NW AD - Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, CU Anschutz, Aurora, Colorado. FAU - Ramirez-Cardenas, Alejandra AU - Ramirez-Cardenas A AUID- ORCID: 0000-0001-6451-480X AD - National Institute for Occupational Safety and Health (NIOSH) Western States Division, Denver, Colorado. FAU - Wingate, Kaitlin C AU - Wingate KC AUID- ORCID: 0000-0001-7475-8074 AD - National Institute for Occupational Safety and Health (NIOSH) Western States Division, Denver, Colorado. FAU - King, Bradley S AU - King BS AUID- ORCID: 0000-0002-5075-2986 AD - National Institute for Occupational Safety and Health (NIOSH) Western States Division, Denver, Colorado. FAU - Scott, Kenneth AU - Scott K AUID- ORCID: 0000-0002-2192-5526 AD - National Institute for Occupational Safety and Health (NIOSH) Western States Division, Denver, Colorado. FAU - Hagan-Haynes, Kyla AU - Hagan-Haynes K AUID- ORCID: 0000-0003-2278-075X AD - National Institute for Occupational Safety and Health (NIOSH) Western States Division, Denver, Colorado. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States GR - T42 OH009229/OH/NIOSH CDC HHS/United States GR - T42OH009229/ACL/ACL HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20231115 PL - England TA - J Occup Environ Hyg JT - Journal of occupational and environmental hygiene JID - 101189458 SB - IM MH - United States/epidemiology MH - Humans MH - *Heat Stress Disorders/prevention & control MH - Risk Factors MH - Workplace MH - Industry MH - *Occupational Health PMC - PMC10959173 MID - NIHMS1967720 OTO - NOTNLM OT - Heat stress OT - OGE OT - heatstroke OT - outdoor workers COIS- Disclosure statement No potential conflict of interest was reported by the author(s). EDAT- 2023/10/13 12:42 MHDA- 2024/02/15 06:43 PMCR- 2024/03/22 CRDT- 2023/10/13 09:53 PHST- 2024/02/15 06:43 [medline] PHST- 2023/10/13 12:42 [pubmed] PHST- 2023/10/13 09:53 [entrez] PHST- 2024/03/22 00:00 [pmc-release] AID - 10.1080/15459624.2023.2268142 [doi] PST - ppublish SO - J Occup Environ Hyg. 2024 Jan;21(1):58-67. doi: 10.1080/15459624.2023.2268142. Epub 2023 Nov 15. PMID- 37549227 OWN - NLM STAT- MEDLINE DCOM- 20230921 LR - 20230921 IS - 1438-8677 (Electronic) IS - 1435-8603 (Linking) VI - 25 IP - 6 DP - 2023 Oct TI - 24-Epibrassinolide alleviates drought effects in young Carapa guianensis plants, improving the hydraulic safety margin, gas exchange and antioxidant defence. PG - 924-934 LID - 10.1111/plb.13563 [doi] AB - Climate change is increasing the frequency of extreme events such as droughts, limiting plant growth and productivity. Exogenous application of plant growth regulators, such as 24-epibrassinolide (EBR), might be a solution as this molecule is organic, eco-friendly, and biodegradable. This is the first research to examine possible roles of EBR on the hydraulic safety margin, physiological behaviour, and metabolism in Carapa guianensis Aubl. (Meliaceae) exposed to drought. C. guianensis is a widely distributed tree in tropical forests of the Amazon. The objective was to determine whether EBR can improve tolerance to water deficit in young C. guianensis by measuring hydraulic traits, nutritional, biochemical and physiological responses, and biomass. The experiment had four randomized treatments: two water conditions (control and water deficit) and two concentrations of EBR (0 and 100 nM EBR). EBR increased the water potential and hydraulic safety margin, increased CO(2) fixation, and improved stomatal performance. EBR also stimulated antioxidant defences (SOD, CAT, APX, and POX). Overall, tretreatment with EBR improved drought tolerance of young C. guianensis plants. CI - © 2023 John Wiley & Sons Ltd. Published by John Wiley & Sons Ltd. FAU - Ribeiro, A T AU - Ribeiro AT AD - Programa de Pós-Graduação em Botânica, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil. FAU - Teodoro, G S AU - Teodoro GS AD - Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil. FAU - da Silva, K C AU - da Silva KC AD - Programa de Pós-Graduação em Botânica, Coordenação de Botânica, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil. FAU - Pereira-Matos, Y C AU - Pereira-Matos YC AD - Núcleo de Pesquisa Vegetal Básica e Aplicada, Universidade Federal Rural da Amazônia, Paragominas, Pará, Brazil. FAU - Batista, B L AU - Batista BL AD - Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo, Brazil. FAU - Lobato, A K S AU - Lobato AKS AUID- ORCID: 0000-0002-2641-6122 AD - Núcleo de Pesquisa Vegetal Básica e Aplicada, Universidade Federal Rural da Amazônia, Paragominas, Pará, Brazil. LA - eng GR - Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq/Brazil)/ GR - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES/Brazil);/ GR - Fundação Amazônia de Amparo a Estudos e Pesquisas (FAPESPA/Brazil)/ GR - L'ORÉAL-UNESCO-ABC "Para Mulheres na Ciência"/ GR - Universidade Federal Rural da Amazônia (UFRA/Brazil)/ PT - Journal Article DEP - 20230807 PL - England TA - Plant Biol (Stuttg) JT - Plant biology (Stuttgart, Germany) JID - 101148926 RN - Y9IQ1L53OX (brassinolide) RN - 0 (Antioxidants) RN - 0 (Brassinosteroids) RN - 059QF0KO0R (Water) SB - IM MH - *Antioxidants/metabolism MH - *Droughts MH - Brassinosteroids/metabolism MH - Water/metabolism MH - Plant Leaves/metabolism OTO - NOTNLM OT - Amazon tree OT - brassinosteroids OT - peroxidase OT - photosynthesis OT - water deficit EDAT- 2023/08/07 19:10 MHDA- 2023/09/21 06:42 CRDT- 2023/08/07 14:23 PHST- 2023/05/26 00:00 [received] PHST- 2023/07/12 00:00 [accepted] PHST- 2023/09/21 06:42 [medline] PHST- 2023/08/07 19:10 [pubmed] PHST- 2023/08/07 14:23 [entrez] AID - 10.1111/plb.13563 [doi] PST - ppublish SO - Plant Biol (Stuttg). 2023 Oct;25(6):924-934. doi: 10.1111/plb.13563. Epub 2023 Aug 7. PMID- 17169008 OWN - NLM STAT- MEDLINE DCOM- 20071218 LR - 20131125 IS - 1368-504X (Print) IS - 1368-504X (Linking) IP - 151 DP - 2006 Dec TI - The emerging role of intravesical botulinum toxin therapy in idiopathic detrusor overactivity. PG - 27-32 AB - Recently there has been considerable original research into the use of the botulinum neurotoxins in idiopathic detrusor overactivity (DO). This common condition underlies the overactive bladder syndrome in a significant proportion of cases and was previously known as idiopathic detrusor instability. Failure of initial pharmacotherapy in this condition leaves few effective conservative/medical treatment options. Early reports of botulinum toxin (BoNT) therapy have been extremely promising, and the therapy appears to bridge the gap in such patients, before resorting to invasive surgical procedures. Approximately 30 studies have been reported often with widely differing techniques and some clinicians are beginning to administer BoNT for this unlicensed indication. This has led to the urgent need to critically review all available evidence to assess efficacy, safety and technique. In addition to performing a systematic Medline review, all abstracts presented to urological, urogynaecological and incontinence meetings that reported BoNT usage in idiopathic DO were analysed. Remarkable efficacy has been demonstrated in the vast majority of reported series and the treatment has also been used safely in paediatric and elderly populations. Side effects in all populations appear to be minimal and short lived. However, all the series are small and there remains a considerable number of fundamental questions to be answered. Hopefully large-scale robust randomised controlled trials will provide the necessary answers to facilitate the widespread adoption of this technique. Until then caution must be exercised in this unlicensed indication. FAU - Patel, A K AU - Patel AK AD - Sheffield Teaching Hospitals NHS Trust, Urology Research Department, Royal Hallamshire Hospital, Sheffield, UK. FAU - Patterson, J M AU - Patterson JM FAU - Chapple, C R AU - Chapple CR LA - eng PT - Journal Article PT - Review PL - England TA - Int J Clin Pract Suppl JT - International journal of clinical practice. Supplement JID - 9712380 RN - 0 (Neuromuscular Agents) RN - 0Y70779M1F (rimabotulinumtoxinB) RN - EC 3.4.24.69 (Botulinum Toxins) RN - EC 3.4.24.69 (Botulinum Toxins, Type A) SB - IM MH - Aged MH - Botulinum Toxins/adverse effects/therapeutic use MH - Botulinum Toxins, Type A/adverse effects/*therapeutic use MH - Child MH - Dose-Response Relationship, Drug MH - Drug Administration Schedule MH - Humans MH - Neuromuscular Agents/adverse effects/*therapeutic use MH - Treatment Outcome MH - Urinary Bladder, Overactive/*drug therapy RF - 39 EDAT- 2006/12/16 09:00 MHDA- 2007/12/19 09:00 CRDT- 2006/12/16 09:00 PHST- 2006/12/16 09:00 [pubmed] PHST- 2007/12/19 09:00 [medline] PHST- 2006/12/16 09:00 [entrez] AID - IJCP1212 [pii] AID - 10.1111/j.1742-1241.2006.01212.x [doi] PST - ppublish SO - Int J Clin Pract Suppl. 2006 Dec;(151):27-32. doi: 10.1111/j.1742-1241.2006.01212.x. PMID- 28853321 OWN - NLM STAT- MEDLINE DCOM- 20180924 LR - 20180924 IS - 1745-7319 (Electronic) IS - 1745-7300 (Linking) VI - 25 IP - 2 DP - 2018 Jun TI - Investigation of contributing factors to extremely severe traffic crashes using survival theory. PG - 141-153 LID - 10.1080/17457300.2017.1363784 [doi] AB - This study aimed to investigate the contributing factors to serious casualty crashes in China. Crashes with deaths greater than 10 people are defined as serious casualty crashes in China. The serious casualty crash data were collected from 2009 to 2014. The random forest analysis was first conducted to select the candidate variables that affect the risks of serious casualty crashes. The Bayesian random parameters accelerated failure time (AFT) model was then developed to link the probability of the serious casualty crash with road geometric conditions, pavement conditions, environmental characteristics, collision characteristics, vehicle conditions, and driver characteristics. The AFT model estimation results indicate that overload driving, country road, northwest china region, turnover crash, private car, snowy or icy road surface and sight distance conditions have significant fixed effects on the likelihood of serious casualty crashes. In addition to these fixed-parameter variables, freeway, clear weather conditions, coach drivers, and upgrade horizontal curve affect the likelihood of serious casualty crashes with varying magnitude across observations. One of the important findings is that the serious casualty crash likelihood does not always decrease with an increase in the driving experience (number of years driven). Before the inflection point of 7 years, the serious casualty crash likelihood increases as the driving experience grows. The results of this study can help to develop effective countermeasures and policy initiatives for the prevention of serious casualty crashes. FAU - Xu, Chengcheng AU - Xu C AD - a Jiangsu Key Laboratory of Urban ITS , Southeast University , Nanjing , China. AD - b Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies , Southeast University , Nanjing , China. FAU - Bao, Jie AU - Bao J AD - a Jiangsu Key Laboratory of Urban ITS , Southeast University , Nanjing , China. AD - b Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies , Southeast University , Nanjing , China. FAU - Liu, Pan AU - Liu P AD - a Jiangsu Key Laboratory of Urban ITS , Southeast University , Nanjing , China. AD - b Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies , Southeast University , Nanjing , China. FAU - Wang, Wei AU - Wang W AD - a Jiangsu Key Laboratory of Urban ITS , Southeast University , Nanjing , China. AD - b Jiangsu Province Collaborative Innovation Center of Modern Urban Traffic Technologies , Southeast University , Nanjing , China. LA - eng PT - Journal Article DEP - 20170830 PL - England TA - Int J Inj Contr Saf Promot JT - International journal of injury control and safety promotion JID - 101247254 SB - IM MH - Accidents, Traffic/*classification/statistics & numerical data MH - Bayes Theorem MH - *Causality MH - China/epidemiology MH - Databases, Factual MH - Humans MH - Models, Statistical MH - *Survival Analysis MH - Wounds and Injuries/*mortality OTO - NOTNLM OT - Bayesian survival analysis OT - Serious casualty crashes OT - accelerated failure time model OT - duration until-crash occurrence OT - random-parameter regression OT - traffic safety EDAT- 2017/08/31 06:00 MHDA- 2018/09/25 06:00 CRDT- 2017/08/31 06:00 PHST- 2017/08/31 06:00 [pubmed] PHST- 2018/09/25 06:00 [medline] PHST- 2017/08/31 06:00 [entrez] AID - 10.1080/17457300.2017.1363784 [doi] PST - ppublish SO - Int J Inj Contr Saf Promot. 2018 Jun;25(2):141-153. doi: 10.1080/17457300.2017.1363784. Epub 2017 Aug 30. PMID- 39333641 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240930 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 14 IP - 1 DP - 2024 Sep 27 TI - Remote sensing identification and hazard assessment methods for spoil sites. PG - 22121 LID - 10.1038/s41598-024-72942-7 [doi] LID - 22121 AB - Spoil sites, as loose accumulations, are prone to instability after disturbances and are a serious threat to the safety of downstream communities. This research aims to rapidly and accurately assess the potential hazards of the numerous spoil sides. An integrated approach that combines spatial, aerial, and ground techniques was developed to rapidly identify and interpret the key factors influencing the stability of spoil sites. Subsequently, based on the results of numerical simulation of multiple combinations of unfavorable working conditions by the material point method, a hazard assessment methodology for spoil sites is proposed, which combines the limit equilibrium method with the improved hierarchical analysis. The proposed method is applied and validated on spoil sites along an expressway. The achieved results reveal that remote sensing combined with unmanned aerial vehicle (UAV) verification technology is capable of quickly and accurately identifying the critical elements of spoil sites. The hazard assessment of the spoil site is represented by the hazard coefficient (P), where 0 < P < 1 indicates safety, 1 ≤ P < 5 signifies instability, and P ≥ 5 represents extreme instability. The effectiveness of the proposed assessment approach is then verified through the on-site validation, which provides a vital reference for rapid identification and batch assessment of spoil sites. CI - © 2024. The Author(s). FAU - Xiao, Wei AU - Xiao W AD - School of civil engineering, Chang'an University, Xi'an, Shaanxi, China. wei.xiao@chd.edu.cn. FAU - Tian, Weiping AU - Tian W AD - Key Laboratory for Special Area Highway Engineering of Ministry of Education, Chang'an University, Xi'an, China. LA - eng GR - No. 2022JQ-277/Natural Science Basic Research Program of Shaanxi Province/ GR - NO.300102282110/Central Special Fund for scientific research in colleges and universities/ PT - Journal Article DEP - 20240927 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM PMC - PMC11436871 OTO - NOTNLM OT - Hazard assessment OT - Improved hierarchical analysis OT - Material point method OT - Remote sensing identification OT - Spoil sites COIS- The authors declare no competing interests. EDAT- 2024/09/28 09:47 MHDA- 2024/09/28 09:48 PMCR- 2024/09/27 CRDT- 2024/09/27 23:54 PHST- 2024/04/29 00:00 [received] PHST- 2024/09/11 00:00 [accepted] PHST- 2024/09/28 09:48 [medline] PHST- 2024/09/28 09:47 [pubmed] PHST- 2024/09/27 23:54 [entrez] PHST- 2024/09/27 00:00 [pmc-release] AID - 10.1038/s41598-024-72942-7 [pii] AID - 72942 [pii] AID - 10.1038/s41598-024-72942-7 [doi] PST - epublish SO - Sci Rep. 2024 Sep 27;14(1):22121. doi: 10.1038/s41598-024-72942-7. PMID- 2822484 OWN - NLM STAT- MEDLINE DCOM- 19871209 LR - 20190621 IS - 0014-5793 (Print) IS - 0014-5793 (Linking) VI - 223 IP - 2 DP - 1987 Nov 2 TI - The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria. PG - 247-50 AB - The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non-rate limiting creatine phosphokinase ADP-regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30-70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62-0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation. FAU - Kholodenko, B AU - Kholodenko B AD - Research Institute for Technology and Safety of Drugs, Moscow Region, USSR. FAU - Zilinskiene, V AU - Zilinskiene V FAU - Borutaite, V AU - Borutaite V FAU - Ivanoviene, L AU - Ivanoviene L FAU - Toleikis, A AU - Toleikis A FAU - Praskevicius, A AU - Praskevicius A LA - eng PT - Journal Article PL - England TA - FEBS Lett JT - FEBS letters JID - 0155157 RN - 020IUV4N33 (Phosphocreatine) RN - 17754-44-8 (Atractyloside) RN - 9068-80-8 (Mitochondrial ADP, ATP Translocases) RN - EC 2.7.7.- (Nucleotidyltransferases) RN - SNP1XL23E6 (carboxyatractyloside) SB - IM MH - Animals MH - Atractyloside/analogs & derivatives MH - Mitochondria, Heart/*physiology MH - Mitochondrial ADP, ATP Translocases/*physiology MH - Nucleotidyltransferases/*physiology MH - *Oxidative Phosphorylation MH - Oxygen Consumption MH - Phosphocreatine/metabolism MH - Rabbits EDAT- 1987/11/02 00:00 MHDA- 1987/11/02 00:01 CRDT- 1987/11/02 00:00 PHST- 1987/11/02 00:00 [pubmed] PHST- 1987/11/02 00:01 [medline] PHST- 1987/11/02 00:00 [entrez] AID - 10.1016/0014-5793(87)80298-3 [doi] PST - ppublish SO - FEBS Lett. 1987 Nov 2;223(2):247-50. doi: 10.1016/0014-5793(87)80298-3. PMID- 39940563 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250215 IS - 2073-4360 (Electronic) IS - 2073-4360 (Linking) VI - 17 IP - 3 DP - 2025 Jan 28 TI - Novel Inlay Methodology with Thermoplastic and Heating System for Durable Road Markings. LID - 10.3390/polym17030361 [doi] LID - 361 AB - Road markings, such as lane dividers and pedestrian crossings, are integral in ensuring the safety of road users. However, traditional markings frequently exhibit limitations, including short lifespans, diminished visibility, and significant maintenance costs, particularly as traffic volumes increase. To address these persistent challenges, this study presents a thermoplastic road marking system that combines material innovation and advanced application techniques. Central to this approach is the portable heating system, equipped with ceramic heaters and precise temperature controls, which facilitates uniform heating while mitigating fire risks. The thermoplastic blend, processed into pre-formed sheets, was integrated with this heating technology. Together, these components enabled a two-phase process, engraving asphalt surfaces followed by sheet integration, that ensured robust adhesion and seamless bonding. Field trials conducted on various asphalt types validated the system's reliability, demonstrating its durability under traffic loads and consistent visibility. By integrating durable materials with advanced application methods, this methodology significantly enhances the efficiency, longevity, and safety of road markings. It presents a practical and scalable solution for modern infrastructure needs. Future research will focus on evaluating the system's long-term performance under extreme weather conditions to further optimize its applicability. FAU - Kim, Kwan Kyu AU - Kim KK AD - Korea Conformity Laboratories, Chuncheon 24341, Republic of Korea. FAU - Jun, Chul Soo AU - Jun CS AD - U-TECH Co., Ltd., Chuncheon 24341, Republic of Korea. FAU - Lee, Hee Jun AU - Lee HJ AUID- ORCID: 0000-0002-3684-8607 AD - California Department of Transportation, Fresno, CA 93728, USA. FAU - Rodrigazo, Shanelle Aira AU - Rodrigazo SA AUID- ORCID: 0009-0008-9537-5003 AD - Department of Regional Infrastructure Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea. FAU - Yeon, Jaeheum AU - Yeon J AUID- ORCID: 0000-0002-3603-8305 AD - Department of Regional Infrastructure Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea. LA - eng GR - S3231176/Ministry of SMEs and Startups/ PT - Journal Article DEP - 20250128 PL - Switzerland TA - Polymers (Basel) JT - Polymers JID - 101545357 PMC - PMC11821035 OTO - NOTNLM OT - durability OT - heating system OT - inlay technique OT - road marking OT - thermoplastic polymers COIS- Author Chul Soo Jun was employed by the company U-TECH Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/02/13 11:01 MHDA- 2025/02/13 11:02 PMCR- 2025/01/28 CRDT- 2025/02/13 01:03 PHST- 2024/12/19 00:00 [received] PHST- 2025/01/23 00:00 [revised] PHST- 2025/01/26 00:00 [accepted] PHST- 2025/02/13 11:02 [medline] PHST- 2025/02/13 11:01 [pubmed] PHST- 2025/02/13 01:03 [entrez] PHST- 2025/01/28 00:00 [pmc-release] AID - polym17030361 [pii] AID - polymers-17-00361 [pii] AID - 10.3390/polym17030361 [doi] PST - epublish SO - Polymers (Basel). 2025 Jan 28;17(3):361. doi: 10.3390/polym17030361. PMID- 38863281 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240819 IS - 1521-3773 (Electronic) IS - 1433-7851 (Linking) VI - 63 IP - 35 DP - 2024 Aug 26 TI - A Facile Strategy for Constructing High-Performance Polymer Electrolytes via Anion Modification and Click Chemistry for Rechargeable Magnesium Batteries. PG - e202406585 LID - 10.1002/anie.202406585 [doi] AB - Polymer electrolytes play a crucial role in advancing rechargeable magnesium batteries (RMBs) owing to their exceptional characteristics, including high flexibility, superior interface compatibility, broad electrochemical stability window, and enhanced safety features. Despite these advantages, research in this domain remains nascent, plagued by single preparation approaches and challenges associated with the compatibility between polymer electrolytes and Mg metal anode. In this study, we present a novel synthesis strategy to fabricate a glycerol α,α'-diallyl ether-3,6-dioxa-1,8-octanedithiol-based composite gel polymer electrolyte supported by glass fiber substrate (GDT@GF CGPE) through anion modification and thiol-ene click chemistry polymerization. The developed route exhibits novelty and high efficiency, leading to the production of GDT@GF CGPEs featuring exceptional mechanical properties, heightened ionic conductivity, elevated Mg(2+) transference number, and commendable compatibility with Mg anode. The assembled modified Mo(6)S(8)||GDT@GF||Mg cells exhibit outstanding performance across a wide temperature range and address critical safety concerns, showcasing the potential for applications under extreme conditions. Our innovative preparation strategy offers a promising avenue for the advancement of polymer electrolytes in high-performance rechargeable magnesium batteries, while also opens up possibilities for future large-scale applications and the development of flexible electronic devices. CI - © 2024 Wiley-VCH GmbH. FAU - Sun, Yukun AU - Sun Y AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Pan, Ming AU - Pan M AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Wang, Yuanhao AU - Wang Y AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Hu, Anyi AU - Hu A AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Zhou, Qinnan AU - Zhou Q AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Zhang, Duo AU - Zhang D AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Zhang, Shuxin AU - Zhang S AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Zhao, Yazhen AU - Zhao Y AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Wang, Yaru AU - Wang Y AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Chen, Shaopeng AU - Chen S AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Zhou, Miao AU - Zhou M AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Chen, Yan AU - Chen Y AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Yang, Jun AU - Yang J AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - Wang, nJiulin AU - Wang N AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. FAU - NuLi, Yanna AU - NuLi Y AUID- ORCID: 0000-0003-0604-8550 AD - School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, 200240, Shanghai, China. LA - eng GR - National Natural Science Foundation of China/ PT - Journal Article DEP - 20240725 PL - Germany TA - Angew Chem Int Ed Engl JT - Angewandte Chemie (International ed. in English) JID - 0370543 SB - IM OTO - NOTNLM OT - Click chemistry polymerization OT - High comprehensive performance OT - Mechanism analysis OT - Polymer electrolytes OT - Rechargeable magnesium batteries EDAT- 2024/06/12 06:42 MHDA- 2024/06/12 06:43 CRDT- 2024/06/12 02:33 PHST- 2024/04/07 00:00 [received] PHST- 2024/06/12 06:43 [medline] PHST- 2024/06/12 06:42 [pubmed] PHST- 2024/06/12 02:33 [entrez] AID - 10.1002/anie.202406585 [doi] PST - ppublish SO - Angew Chem Int Ed Engl. 2024 Aug 26;63(35):e202406585. doi: 10.1002/anie.202406585. Epub 2024 Jul 25. PMID- 36816273 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240912 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 9 IP - 2 DP - 2023 Feb TI - Safety, high-performing and effects of the N/P ratio of a solid lithium ion battery using PEGDME based polymer electrolytes. PG - e13292 LID - 10.1016/j.heliyon.2023.e13292 [doi] LID - e13292 AB - In this study, we report on the electrochemical properties of a solid state lithium ion battery (LIB) using a poly (ethylene glycol) dimethyl ether (PEGDME)-based solid polymer electrolyte (P-SPE). The LIB is prepared using a LiFePO(4) (LFP) cathode and graphite anode material with P-SPE, and the kinetic properties of the lithium ions in the P-SPE are investigated. The synthesized P-SPE is shown to be suitable solid polymer electrolyte candidate for LIB applications. LFP and graphite are selected as electrode materials to validate their effectiveness in different battery cells with respect to their high energy density and inherent safety. The five-layer stacked 5 × 6 cm(2) pouch-type LIB demonstrates a high capacity of 90 mAh (0.6 mAh/cm(2)) or more in the initial cycle, and it shows cycle stability with a capacity decrease of 20% over 500 cycles. We test the manufactured pouch-type full cells under extreme conditions (e. g., cutting, crushing and exposure of the battery cell to the atmosphere). LIBs using the developed P-SPE are promising solid polymer electrolyte candidates for wearable LIB as well as high energy LIB applications. CI - © 2023 Published by Elsevier Ltd. FAU - Jeon, Injun AU - Jeon I AD - Korea Basic Science Institute, Busan, South Korea. AD - Department of Nano Fusion Technology, Pusan National University, South Korea. FAU - Hong, Won Gi AU - Hong WG AD - Korea Basic Science Institute, Daejeon, South Korea. FAU - Yoon, Sol AU - Yoon S AD - Korea Basic Science Institute, Daejeon, South Korea. FAU - Choi, Yunju AU - Choi Y AD - Korea Basic Science Institute, Busan, South Korea. FAU - Kim, Hae Jin AU - Kim HJ AD - Korea Basic Science Institute, Daejeon, South Korea. FAU - Kim, Jong-Pil AU - Kim JP AD - Korea Basic Science Institute, Busan, South Korea. LA - eng PT - Journal Article DEP - 20230129 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC9929294 OTO - NOTNLM OT - Full cell OT - LFP, LiFePO4 OT - LIB, lithium ion battery OT - N/P ratios OT - P-SPE, PEGDME-based solid polymer electrolyte OT - PEGDME, poly (ethylene glycol) dimethyl ether OT - PEO, polyethylene oxide OT - Pouch-type OT - Solid polymer electrolyte OT - Wearable LIB COIS- The authors declare no competing interests. EDAT- 2023/02/24 06:00 MHDA- 2023/02/24 06:01 PMCR- 2023/01/29 CRDT- 2023/02/23 09:19 PHST- 2022/11/10 00:00 [received] PHST- 2023/01/17 00:00 [revised] PHST- 2023/01/25 00:00 [accepted] PHST- 2023/02/23 09:19 [entrez] PHST- 2023/02/24 06:00 [pubmed] PHST- 2023/02/24 06:01 [medline] PHST- 2023/01/29 00:00 [pmc-release] AID - S2405-8440(23)00499-1 [pii] AID - e13292 [pii] AID - 10.1016/j.heliyon.2023.e13292 [doi] PST - epublish SO - Heliyon. 2023 Jan 29;9(2):e13292. doi: 10.1016/j.heliyon.2023.e13292. eCollection 2023 Feb. PMID- 22098811 OWN - NLM STAT- MEDLINE DCOM- 20120228 LR - 20111121 IS - 1558-3147 (Electronic) IS - 0193-953X (Linking) VI - 34 IP - 4 DP - 2011 Dec TI - Surgical treatments for obesity. PG - 881-93 LID - 10.1016/j.psc.2011.08.012 [doi] AB - Bariatric surgery is currently the most effective and durable treatment option for extreme obesity. Restrictive procedures, such as AGB and SG, limit gastric capacity and, thus, food intake while leaving the gastrointestinal tract intact. Malabsorptive procedures, such as BPD, shorten the length of the intestine to decrease nutrient absorption. Combined procedures, such as RYGB, include restriction and gastrointestinal rearrangement. Procedures that bypass segments of the gut are associated with greater weight loss and greater improvements in comorbid conditions than is gastric banding. This may be due, in part, to the differential effects of gastrointestinal rearrangement on the secretion of orexigenic and anorexigenic gut peptides that regulate appetite, glucose homeostasis, and body weight. Bariatric surgery is generally associated with low rates of perioperative and postoperative morbidity and mortality, although rigorous comparative safety data are lacking. High-quality, long-term, randomized, controlled trials are needed to compare the efficacy, safety, and cost effectiveness of the various bariatric surgery procedures with each other, as well as with intensive nonsurgical weight loss interventions. FAU - Vetter, Marion L AU - Vetter ML AD - Department of Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, 4 Silverstein, Philadelphia, PA 19104, USA. marion.vetter@uphs.upenn.edu FAU - Dumon, Kristoffel R AU - Dumon KR FAU - Williams, Noel N AU - Williams NN LA - eng PT - Journal Article PL - United States TA - Psychiatr Clin North Am JT - The Psychiatric clinics of North America JID - 7708110 RN - 0 (Ghrelin) RN - 106388-42-5 (Peptide YY) RN - 89750-14-1 (Glucagon-Like Peptide 1) SB - IM MH - Anastomosis, Roux-en-Y/methods MH - Bariatric Surgery/*methods MH - Biliopancreatic Diversion/methods MH - Endoscopy, Digestive System/methods MH - Ghrelin/metabolism/physiology MH - Glucagon-Like Peptide 1/metabolism/physiology MH - Humans MH - Obesity/metabolism/mortality/*surgery MH - Peptide YY/metabolism/physiology MH - Treatment Outcome MH - *Weight Loss EDAT- 2011/11/22 06:00 MHDA- 2012/03/01 06:00 CRDT- 2011/11/22 06:00 PHST- 2011/11/22 06:00 [entrez] PHST- 2011/11/22 06:00 [pubmed] PHST- 2012/03/01 06:00 [medline] AID - S0193-953X(11)00089-X [pii] AID - 10.1016/j.psc.2011.08.012 [doi] PST - ppublish SO - Psychiatr Clin North Am. 2011 Dec;34(4):881-93. doi: 10.1016/j.psc.2011.08.012. PMID- 1597765 OWN - NLM STAT- MEDLINE DCOM- 19920709 LR - 20190918 IS - 0096-1736 (Print) IS - 0096-1736 (Linking) VI - 34 IP - 2 DP - 1992 Feb TI - Arm pain in the workplace. A small area analysis. PG - 113-9 AB - In the mid-1980s, use-related arm pain was recognized as a major issue for worker health and workplace safety. National policy targeted these "cumulative trauma disorders," "overuse syndromes," and "motion illnesses" for a "special emphasis program" by the Occupational Safety and Health Administration, a federal regulatory agency. The program begins with case recognition to identify the responsible ergonomic hazards with the goal of mandating ergonomic remedies. This report is a small area analysis of the impact of this process on the US West Communications, Inc work force. US West employs some 55,000 workers in 14 states. Commencing in the mid-1980s, workers in four of these states complained of upper extremity pain and were diagnosed as suffering from conditions encompassed by the "cumulative trauma disorders" rubric. The incidence was tenfold higher in one task category, directory assistance operators. No ergonomic descriptor can account for the four endemics of arm pain in directory assistance operators. The response of the medical communities to the plight of these injured claimants varied considerably from community to community. Denver represents one extreme where the clinical judgments led to multiple surgical interventions, generated a total direct cost of some $1.5 million, and left many permanently disabled workers in their wake. This analysis raises many reservations about the validity of the "cumulative trauma disorder" hypothesis and provides an object lesson in the potential for untoward outcomes from the premature introduction of clinical hypotheses into the arena of health policy. FAU - Hadler, N M AU - Hadler NM AD - School of Medicine, University of North Carolina, Chapel Hill 27599-7280. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Occup Med JT - Journal of occupational medicine. : official publication of the Industrial Medical Association JID - 7502807 SB - IM CIN - J Occup Med. 1992 Nov;34(11):1119-21. doi: 10.1097/00043764-199211000-00018. PMID: 1432305 CIN - J Occup Med. 1994 Jul;36(7):708. PMID: 7931734 MH - Adult MH - *Arm MH - Cumulative Trauma Disorders/epidemiology MH - Ergonomics MH - Female MH - Humans MH - Male MH - Minnesota/epidemiology MH - Northwestern United States/epidemiology MH - Occupational Diseases/*epidemiology MH - Pain/*epidemiology MH - Small-Area Analysis MH - Southwestern United States/epidemiology EDAT- 1992/02/01 00:00 MHDA- 1992/02/01 00:01 CRDT- 1992/02/01 00:00 PHST- 1992/02/01 00:00 [pubmed] PHST- 1992/02/01 00:01 [medline] PHST- 1992/02/01 00:00 [entrez] AID - 10.1097/00043764-199202000-00009 [doi] PST - ppublish SO - J Occup Med. 1992 Feb;34(2):113-9. doi: 10.1097/00043764-199202000-00009. PMID- 18573217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20240511 IS - 1755-7682 (Electronic) IS - 1755-7682 (Linking) VI - 1 IP - 1 DP - 2008 Jun 23 TI - The variant Creutzfeldt-Jakob Disease: Risk, uncertainty or safety in the use of blood and blood derivatives? PG - 9 LID - 10.1186/1755-7682-1-9 [doi] AB - It has been long since French physician Jean-Baptiste Denys carried out the first successful blood transfusion to a human being. Using bird feathers as canules, sheep blood was transfused to a young man. The patient died soon after Denys' treatment and Denys was accused of murder. In the XXI century, known as the biotechnology century, we face new challenges in Medicine. New emerging and reemerging diseases, such as Creutzfeldt-Jakob disease (CJD) or "mad cow disease" and its human variant (vCJD), challenge the biosafety aspects of a widely extended and extremely useful technique, that is, the perfusion of blood, of its derived components and of other pharmacological products obtained from plasma. To face these new challenges we need innovative prevention strategies. FAU - Liras, Antonio AU - Liras A AD - Department of Physiology, Biology School, Universidad Complutense of Madrid, Spain. aliras@hotmail.com. LA - eng PT - Journal Article DEP - 20080623 PL - England TA - Int Arch Med JT - International archives of medicine JID - 101317943 PMC - PMC2443133 EDAT- 2008/06/25 09:00 MHDA- 2008/06/25 09:01 PMCR- 2008/06/23 CRDT- 2008/06/25 09:00 PHST- 2008/02/11 00:00 [received] PHST- 2008/06/23 00:00 [accepted] PHST- 2008/06/25 09:00 [pubmed] PHST- 2008/06/25 09:01 [medline] PHST- 2008/06/25 09:00 [entrez] PHST- 2008/06/23 00:00 [pmc-release] AID - 1755-7682-1-9 [pii] AID - 10.1186/1755-7682-1-9 [doi] PST - epublish SO - Int Arch Med. 2008 Jun 23;1(1):9. doi: 10.1186/1755-7682-1-9. PMID- 24090016 OWN - NLM STAT- MEDLINE DCOM- 20150622 LR - 20190918 IS - 1130-0108 (Print) IS - 1130-0108 (Linking) VI - 105 IP - 6 DP - 2013 Jul TI - Impact of combined precut techniques on selective biliary cannulation. PG - 338-44 AB - INTRODUCTION: simple biliary cannulation techniques obtain a success rate of 80-95%. Advanced precut techniques are not immediately successful in 10-40% of cases. Between extreme options such as a second attempt a few days later or an immediate attempt by the transparietal route, an alternative precut technique may be used as a rescue strategy for the initially failed procedure. The purpose of this study was to assess the efficacy and safety of the combined use of two precut techniques when immediate biliary access is not granted by an initial procedure. PATIENTS AND METHOD: a retrospective analysis of a personal series of precut (needle-knife and transpancreatic) sphincterotomies, both alone and in combination. RESULTS: five hundred sixty nine ERCPs (endoscopic retrograde cholangio-pancreatography) met the inclusion criteria for the analysis. Simple cannulation was obtained in 444 (78%) of them. In all, 119 (21%) precuts were attempted and 110 (92.4%) were successful, which raised the overall cannulation rate to 97.4%. Ninety-five (80%) precuts were successful with the initial technique. Rescue with the alternative technique was attempted for 20 failures with a successful outcome in 15, which raised the overall success rate to 92%. The combination of needle-knife precut plus transpancreatic precut raised the success rate from 87% to 94%. The combination of transpancreatic precut plus needle-knife precut raised the success rate from 70% to 90%. Among all 96 patients with available follow-up data, 17 (18%) complications were recorded: 9 bleeding episodes, 4 pancreatitis cases, and 4 retroperitoneal perforations. No mortality was recorded. CONCLUSIONS: a combination of precut techniques is effective for biliary cannulation when simple cannulation and initial precut approaches fail. The safety profile differs from that in the delayed strategy, hence both should be considered alternatives, their use depending on the technical and clinical conditions prevailing for each patient, as well as endoscopist experience. FAU - de-la-Morena-Madrigal, Emilio J AU - de-la-Morena-Madrigal EJ LA - eng PT - Journal Article PL - Spain TA - Rev Esp Enferm Dig JT - Revista espanola de enfermedades digestivas JID - 9007566 SB - IM MH - Bile Ducts MH - Catheterization MH - Humans MH - Retrospective Studies MH - Sphincterotomy, Endoscopic/*methods EDAT- 2013/10/05 06:00 MHDA- 2015/06/24 06:00 CRDT- 2013/10/05 06:00 PHST- 2013/10/05 06:00 [entrez] PHST- 2013/10/05 06:00 [pubmed] PHST- 2015/06/24 06:00 [medline] AID - 10.4321/s1130-01082013000600005 [doi] PST - ppublish SO - Rev Esp Enferm Dig. 2013 Jul;105(6):338-44. doi: 10.4321/s1130-01082013000600005. PMID- 39611093 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241130 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 15 DP - 2024 TI - Screening and genome analysis of heat-resistant and antioxidant lactic acid bacteria from Holstein cow milk. PG - 1455849 LID - 10.3389/fmicb.2024.1455849 [doi] LID - 1455849 AB - BACKGROUND: Heat stress significantly impacts dairy cows, primarily through oxidative stress, which undermines their health. The problem is exacerbated by the ongoing global warming trend. Lactic acid bacteria (LAB) are safe, economical, and readily accessible options for enhancing the host's antioxidant defenses and preventing oxidative damage. They have been proven effective in alleviating heat stress-related damage, making them an excellent choice for protecting dairy cows from the adverse effects of heat stress. METHOD: In this study, five strains of LAB from Holstein cow milk (Lactobacillus plantarum L5, L14, L17, L19, L20) were evaluated for their heat resistance and antioxidant capacity by evaluating the growth characteristics and tolerance of the strains under high-temperature conditions, as well as their H(2)O(2) tolerance, free radical scavenging ability (DPPH, OH(-), ABTS), reducing ability, and EPS production ability. Furthermore, we employed Caco-2 cells to assess the adhesion rate of the strain, thereby confirming its ability to successfully colonize the host's intestinal tract and ensuring the effective execution of its probiotic functions. The strain with excellent heat resistance and antioxidant capacity was then subjected to genomic analysis to gain insight into the molecular mechanisms behind their heat resistance, antioxidant capacity, and safety. RESULTS: Among the two strains, Lactobacillus plantarum L19 emerges as a highly promising candidate. The strain exhibits robust growth even at high temperatures at 40°C and maintains a survival rate of 16.42% at the extreme temperature of 65°C. Furthermore, it demonstrates superior tolerance to hydrogen peroxide (27.3%), and possesses a notably higher free radical scavenging capacity with a high adhesion rate to Caco-2 cell (22.19%) compared to the other four strains tested. Genomic analysis revealed its' genome has 17 genes related to antioxidants and three genes related to heat resistance. Importantly, L19 lacks any resistance genes, ensuring its safety as a probiotic. CONCLUSION: The results imply that Lactobacillus plantarum L19 has the potential to serve as an effective food additive in mitigating damages associated with heat stress. This research offers a valuable reference for the prevention and management of heat stress in dairy cows, while also expanding the scope of applications for LAB derived from cow milk. CI - Copyright © 2024 Wang, Liu, Zheng, Xin, Zhong, Liu, Huang, Fu, Zhou and Peng. FAU - Wang, Jiali AU - Wang J AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Liu, Yunjiang AU - Liu Y AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Zheng, Haohong AU - Zheng H AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Xin, Jialiang AU - Xin J AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Zhong, Zhijun AU - Zhong Z AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Liu, Haifeng AU - Liu H AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Huang, Yixin AU - Huang Y AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Fu, Hualin AU - Fu H AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Zhou, Ziyao AU - Zhou Z AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. FAU - Peng, Guangneng AU - Peng G AD - Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China. LA - eng PT - Journal Article DEP - 20241114 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC11602510 OTO - NOTNLM OT - Lactobacillus plantarum OT - antioxidant capacity OT - dairy cows OT - heat resistance OT - heat stress OT - lactic acid bacteria COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2024/11/29 06:22 MHDA- 2024/11/29 06:23 PMCR- 2024/11/14 CRDT- 2024/11/29 04:27 PHST- 2024/06/27 00:00 [received] PHST- 2024/11/04 00:00 [accepted] PHST- 2024/11/29 06:23 [medline] PHST- 2024/11/29 06:22 [pubmed] PHST- 2024/11/29 04:27 [entrez] PHST- 2024/11/14 00:00 [pmc-release] AID - 10.3389/fmicb.2024.1455849 [doi] PST - epublish SO - Front Microbiol. 2024 Nov 14;15:1455849. doi: 10.3389/fmicb.2024.1455849. eCollection 2024. PMID- 35452417 OWN - NLM STAT- MEDLINE DCOM- 20220909 LR - 20220909 IS - 1078-6791 (Print) IS - 1078-6791 (Linking) VI - 28 IP - 5 DP - 2022 Jul TI - Therapeutic Effects of Curcumin on Osteoarthritis and Its Protection of Chondrocytes Through the Wnt/Β-Catenin Signaling Pathway. PG - 28-37 LID - AT7425 [pii] AB - CONTEXT: Osteoarthritis (OA) is a high-incidence, chronic condition, with an extremely high prevalence among older adults. OA seriously compromises the normal living of OA patients, and it's imperative to find a novel therapy as soon as possible to improve their prognosis and life quality. OBJECTIVE: The study intended to investigate the therapeutic effects of Curcumin (Cur) on OA and to explore its preliminary mechanism of action, with the aim of offering more accurate guidance for use of OA therapy. DESIGN: The research team designed a prospective non-randomized controlled trial. SETTING: The study took place in the Department of Orthopedics at Sir Run Run Hospital at Nanjing Medical University in Nanjing, China. PARTICIPANTS: Participants were 107 OA patients treated at the hospital between March 2019 and January 2020. INTERVENTION: Participants were divided into two groups, 51 in the Cur group and 56 in the ibuprofen group. OUTCOME MEASURES: The clinical efficacy and safety of the two groups were observed. In addition, the research team performed in-vitro studies. Chondrocytes HC-a and C28/I2 were purchased to evaluate the intracellular inflammatory response and apoptosis rate under the intervention of Cur and Wnt/β-catenin pathway inhibitors. RESULTS: No significant differences existed in the clinical-efficacy rate between the two groups (P > .05), but the Cur group show higher improvements in safety, joint mobility, and inhibition of inflammation (P < .05). In-vitro experiments showed that Cur inhibited the apoptosis rate of chondrocytes and the levels of inflammatory factors, while the Wnt/β-catenin inhibitor did the opposite (P < .05). CONCLUSIONS: Cur can effectively decrease the pathological results of OA, with a remarkable safety profile; its mechanism may be the activation of the Wnt/β-catenin signaling pathway to inhibit the inflammatory reaction and apoptosis in chondrocytes. FAU - Yuan, Tangbo AU - Yuan T FAU - Cai, Dawei AU - Cai D FAU - Hu, Bo AU - Hu B FAU - Zhu, Yiran AU - Zhu Y FAU - Qin, Jian AU - Qin J LA - eng PT - Controlled Clinical Trial PT - Journal Article PL - United States TA - Altern Ther Health Med JT - Alternative therapies in health and medicine JID - 9502013 RN - 0 (beta Catenin) RN - IT942ZTH98 (Curcumin) SB - IM MH - Aged MH - *Cartilage, Articular MH - Chondrocytes/metabolism MH - *Curcumin/metabolism/pharmacology/therapeutic use MH - Humans MH - Inflammation/metabolism MH - *Osteoarthritis/drug therapy MH - Prospective Studies MH - Wnt Signaling Pathway/physiology MH - beta Catenin/metabolism/pharmacology/therapeutic use EDAT- 2022/04/23 06:00 MHDA- 2022/09/11 06:00 CRDT- 2022/04/22 17:11 PHST- 2022/04/23 06:00 [pubmed] PHST- 2022/09/11 06:00 [medline] PHST- 2022/04/22 17:11 [entrez] AID - AT7425 [pii] PST - ppublish SO - Altern Ther Health Med. 2022 Jul;28(5):28-37. PMID- 37361169 OWN - NLM STAT- MEDLINE DCOM- 20230628 LR - 20230701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 11 DP - 2023 TI - The analysis and optimization of thermal sensation of train drivers under occupational thermal exposure. PG - 1164817 LID - 10.3389/fpubh.2023.1164817 [doi] LID - 1164817 AB - INTRODUCTION: Prolonged exposure of train drivers to thermal discomfort can lead to occupational safety and health (OSH) risks, causing physical and mental injuries. Traditional method of treating human skin as a wall surface fail to observe accurate skin temperature changes or obtain human thermal comfort that adapts to the thermal environment. METHODS: This study employs the Stolwijk human thermal regulation model to investigate and optimize the thermal comfort of train drivers. To minimize the time-consuming design optimization, a pointer optimization algorithm based on radial basis function (RBF) approximation was utilized to optimize the train cab ventilation system design and enhance drivers' thermal comfort. The train driver thermal comfort model was developed using Star-CCM+ and 60 operating conditions were sampled using an Optimal Latin Hypercube Design (Opt LHD). RESULTS AND DISCUSSION: We analyzed the effects of air supply temperature, air supply volume, air supply angle, solar radiation intensity and solar altitude angle on the local thermal sensation vote (LTSV) and overall thermal sensation vote (OTSV) of the train driver. Finally, the study obtained the optimal air supply parameters for the Heating Ventilation and Air Conditioning (HVAC) in the train cabin under extreme summer conditions, effectively improving the thermal comfort of the driver. CI - Copyright © 2023 Yang, Zhou, Xu, Li, Yang, Xiao, Fan and Peng. FAU - Yang, Zeyun AU - Yang Z AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. AD - Technical Research Department, CRRC Industrial Research Institute (Qingdao) Co., Ltd., Qingdao, China. FAU - Zhou, Wenjun AU - Zhou W AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. FAU - Xu, Gang AU - Xu G AD - Technical Research Department, CRRC Industrial Research Institute (Qingdao) Co., Ltd., Qingdao, China. FAU - Li, Xinkang AU - Li X AD - Technical Research Department, CRRC Industrial Research Institute (Qingdao) Co., Ltd., Qingdao, China. FAU - Yang, Mingzhi AU - Yang M AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. FAU - Xiao, Qiang AU - Xiao Q AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. FAU - Fan, Chaojie AU - Fan C AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. FAU - Peng, Yong AU - Peng Y AD - Key Laboratory of Traffic Safety on Track of Ministry of Education, School of Traffic and Transportation Engineering, Central South University, Changsha, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230609 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Temperature MH - *Skin Temperature MH - *Air Conditioning/methods MH - Heating MH - Thermosensing PMC - PMC10288136 OTO - NOTNLM OT - CFD OT - air supply parameters OT - design and optimization OT - human thermal regulation model OT - occupational thermal exposure OT - thermal sensation OT - train driver COIS- ZY, GX, and XL are employed by CRRC Industrial Research Institute (Qingdao) Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/06/26 19:07 MHDA- 2023/06/28 06:42 PMCR- 2023/06/09 CRDT- 2023/06/26 12:48 PHST- 2023/02/13 00:00 [received] PHST- 2023/05/18 00:00 [accepted] PHST- 2023/06/28 06:42 [medline] PHST- 2023/06/26 19:07 [pubmed] PHST- 2023/06/26 12:48 [entrez] PHST- 2023/06/09 00:00 [pmc-release] AID - 10.3389/fpubh.2023.1164817 [doi] PST - epublish SO - Front Public Health. 2023 Jun 9;11:1164817. doi: 10.3389/fpubh.2023.1164817. eCollection 2023. PMID- 36212831 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221011 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 13 DP - 2022 TI - Colony growth and biofilm formation of Aspergillus niger under simulated microgravity. PG - 975763 LID - 10.3389/fmicb.2022.975763 [doi] LID - 975763 AB - The biotechnology- and medicine-relevant fungus Aspergillus niger is a common colonizer of indoor habitats such as the International Space Station (ISS). Being able to colonize and biodegrade a wide range of surfaces, A. niger can ultimately impact human health and habitat safety. Surface contamination relies on two key-features of the fungal colony: the fungal spores, and the vegetative mycelium, also known as biofilm. Aboard the ISS, microorganisms and astronauts are shielded from extreme temperatures and radiation, but are inevitably affected by spaceflight microgravity. Knowing how microgravity affects A. niger colony growth, in particular regarding the vegetative mycelium (biofilm) and spore production, will help prevent and control fungal contaminations in indoor habitats on Earth and in space. Because fungal colonies grown on agar can be considered analogs for surface contamination, we investigated A. niger colony growth on agar in normal gravity (Ground) and simulated microgravity (SMG) conditions by fast-clinorotation. Three strains were included: a wild-type strain, a pigmentation mutant (ΔfwnA), and a hyperbranching mutant (ΔracA). Our study presents never before seen scanning electron microscopy (SEM) images of A. niger colonies that reveal a complex ultrastructure and biofilm architecture, and provide insights into fungal colony development, both on ground and in simulated microgravity. Results show that simulated microgravity affects colony growth in a strain-dependent manner, leading to thicker biofilms (vegetative mycelium) and increased spore production. We suggest that the Rho GTPase RacA might play a role in A. niger's adaptation to simulated microgravity, as deletion of ΔracA leads to changes in biofilm thickness, spore production and total biomass. We also propose that FwnA-mediated melanin production plays a role in A. niger's microgravity response, as ΔfwnA mutant colonies grown under SMG conditions showed increased colony area and spore production. Taken together, our study shows that simulated microgravity does not inhibit A. niger growth, but rather indicates a potential increase in surface-colonization. Further studies addressing fungal growth and surface contaminations in spaceflight should be conducted, not only to reduce the risk of negatively impacting human health and spacecraft material safety, but also to positively utilize fungal-based biotechnology to acquire needed resources in situ. CI - Copyright © 2022 Cortesão, Holland, Schütze, Laue, Moeller and Meyer. FAU - Cortesão, Marta AU - Cortesão M AD - German Aerospace Center (DLR), Institute of Aerospace Medicine, Radiation Biology Department, Aerospace Microbiology Research Group, Cologne, Germany. AD - Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany. FAU - Holland, Gudrun AU - Holland G AD - Robert Koch Institute, Advanced Light and Electron Microscopy (ZBS 4), Berlin, Germany. FAU - Schütze, Tabea AU - Schütze T AD - Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany. FAU - Laue, Michael AU - Laue M AD - Robert Koch Institute, Advanced Light and Electron Microscopy (ZBS 4), Berlin, Germany. FAU - Moeller, Ralf AU - Moeller R AD - German Aerospace Center (DLR), Institute of Aerospace Medicine, Radiation Biology Department, Aerospace Microbiology Research Group, Cologne, Germany. FAU - Meyer, Vera AU - Meyer V AD - Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany. LA - eng PT - Journal Article DEP - 20220923 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC9539656 OTO - NOTNLM OT - Aspergillus niger OT - biofilm OT - fwnA OT - mycelium network OT - pigmentation OT - racA OT - scanning electron microscopy OT - simulated microgravity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/10/11 06:00 MHDA- 2022/10/11 06:01 PMCR- 2022/09/23 CRDT- 2022/10/10 04:20 PHST- 2022/06/22 00:00 [received] PHST- 2022/08/30 00:00 [accepted] PHST- 2022/10/10 04:20 [entrez] PHST- 2022/10/11 06:00 [pubmed] PHST- 2022/10/11 06:01 [medline] PHST- 2022/09/23 00:00 [pmc-release] AID - 10.3389/fmicb.2022.975763 [doi] PST - epublish SO - Front Microbiol. 2022 Sep 23;13:975763. doi: 10.3389/fmicb.2022.975763. eCollection 2022. PMID- 37888650 OWN - NLM STAT- MEDLINE DCOM- 20231030 LR - 20231030 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 15 IP - 10 DP - 2023 Oct 18 TI - A Narrative Literature Review of the Established Safety of Human Serum Albumin Use as a Stabilizer in Aesthetic Botulinum Toxin Formulations Compared to Alternatives. LID - 10.3390/toxins15100619 [doi] LID - 619 AB - Despite more than 80 years of use in a number of conditions, including in critically ill patients, comments have recently arisen regarding the safety and efficacy of human serum albumin (HSA) as a therapeutic product and stabilizer/excipient in botulinum neurotoxins. This review summarizes the literature on the safety of HSA. Beyond decades of safe use, the largest clinical dataset of HSA safety is a large meta-analysis of HSA supplier data, which found only an extremely remote risk of serious adverse events across millions of doses of therapeutic concentrations of HSA. There is a paucity of literature identifying HSA-specific adverse events when used as a stabilizer/excipient; however, studies of HSA-containing botulinum neurotoxins (BoNTs) suggest that adverse events are not related to HSA. Polysorbates, which are synthetically produced and not physiologically inert, are contained in pending or new-to-market BoNT formulations. In contrast to HSA, evidence exists to suggest that polysorbates (particularly PS20/PS80) can cause serious adverse events (e.g., hypersensitivity, anaphylaxis, and immunogenicity). FAU - Sattler, Sonja AU - Sattler S AD - Rosenpark Klinik GmbH, 64297 Darmstadt, Germany. FAU - Gollomp, Stephen AU - Gollomp S AD - Lankenau Medical Center, Wynnewood, PA 19096, USA. FAU - Curry, Andrew AU - Curry A AD - Merz Aesthetics, Raleigh, NC 27615, USA. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20231018 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - EC 3.4.24.69 (Botulinum Toxins) RN - ZIF514RVZR (Serum Albumin, Human) RN - 0 (Excipients) RN - 0 (Polysorbates) RN - EC 3.4.24.69 (Botulinum Toxins, Type A) SB - IM MH - Humans MH - *Botulinum Toxins/adverse effects MH - Serum Albumin, Human/adverse effects MH - Excipients MH - Polysorbates MH - *Botulinum Toxins, Type A/adverse effects PMC - PMC10610632 OTO - NOTNLM OT - adverse events OT - human serum albumin OT - polysorbates COIS- S.S. has received research support from and conducted clinical trials for Merz Aesthetics, Allergan Aesthetics, Q-Med/Galderma, LC Chem, Croma, and Crown Laboratories; and acted as a speaker, advisor, or investigator for Merz Pharmaceuticals, Venus Concept, Allergan Aesthetics, Crown Aesthetics, Croma, LG, Galderma, Hallura, and Pulse Biosciences Inc. S.G. has received speaker, consulting, and research funding from Merz and speaker/consulting fees from AbbVie/Allergan. A.C. is an employee of Merz Aesthetics. EDAT- 2023/10/27 12:43 MHDA- 2023/10/30 06:46 PMCR- 2023/10/18 CRDT- 2023/10/27 07:22 PHST- 2023/08/11 00:00 [received] PHST- 2023/10/06 00:00 [revised] PHST- 2023/10/11 00:00 [accepted] PHST- 2023/10/30 06:46 [medline] PHST- 2023/10/27 12:43 [pubmed] PHST- 2023/10/27 07:22 [entrez] PHST- 2023/10/18 00:00 [pmc-release] AID - toxins15100619 [pii] AID - toxins-15-00619 [pii] AID - 10.3390/toxins15100619 [doi] PST - epublish SO - Toxins (Basel). 2023 Oct 18;15(10):619. doi: 10.3390/toxins15100619. PMID- 32309600 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231113 IS - 2359-7232 (Electronic) IS - 2359-7232 (Linking) VI - 6 IP - 1 DP - 2018 Apr 12 TI - An update on the diagnosis of growth hormone deficiency. PG - e82 LID - 10.15190/d.2018.2 [doi] LID - e82 AB - Growth hormone deficiency (GHD) is an endocrine disorder, which may be either isolated or associated with other pituitary hormone deficiencies. In children, short stature is a useful clinical marker for GHD. In contrast, symptomatology is not always so obvious in adults, and the existing methods of testing might be inaccurate and imprecise, especially in the lack of a suggestive clinical profile. Since the quality of life of patients diagnosed with GHD could also be significantly affected, in both children and adults, a correct and accurate diagnosis is therefore tremendously important to select those patients that can benefit from the GH treatment. In general, the endocrine diseases are challenging in terms of diagnosis, the simple measurement of the basal level of hormones is not sufficient for distinguishing between the physiological and pathological conditions. Traditionally, several stimulation tests have been considered by professional clinical guidelines, such as insulin tolerance test (ITT), GHRH-arginine stimulation test and the glucagon stimulation test, and all of them have both advantages and limitations. More recently (December 2017), FDA approved a growth hormone secretagogue receptor agonist, macimorelin, for the diagnosis of adults with GHD. The obvious advantage for macimorelin is the simple oral administration and the high level of agreement with the insulin tolerance test for those patients with organic disease and low levels of insulin-like growth factor (IGF-I). However, the safety profile and the diagnostic value was not yet established for the pediatric population and for those adults with extreme or morbid obesity. In addition, administration of macimorelin with drugs that prolong QT interval and CYP3A4 inducers should be avoided. Genetic screening could obviously bring a great insight in the GHD pathology. However, it remains an open question if it would be also cost effective to include it in the routine evaluation of the patients with GHD. Although major progresses have been made in this area, genetic testing continues to be difficult to access, mostly because of its high costs, especially in the low-income and middle-income countries. CI - Copyright © 2018, Applied Systems. FAU - Gabreanu, Georgiana Roxana AU - Gabreanu GR AD - Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. LA - eng PT - Journal Article PT - Review DEP - 20180412 PL - Romania TA - Discoveries (Craiova) JT - Discoveries (Craiova, Romania) JID - 101665061 PMC - PMC6941588 OTO - NOTNLM OT - GHRH-arginine stimulation test OT - Glucagon stimulation test OT - Growth hormone deficiency OT - IGF- Binding protein 3 OT - Insulin-like Growth Factor-1 OT - genetic testing OT - insuline tolerance test (ITT) OT - macimorelin COIS- Conflict of interests: The author declares no conflicts of interest. EDAT- 2018/04/12 00:00 MHDA- 2018/04/12 00:01 PMCR- 2018/04/12 CRDT- 2020/04/21 06:00 PHST- 2020/04/21 06:00 [entrez] PHST- 2018/04/12 00:00 [pubmed] PHST- 2018/04/12 00:01 [medline] PHST- 2018/04/12 00:00 [pmc-release] AID - 188 [pii] AID - 10.15190/d.2018.2 [doi] PST - epublish SO - Discoveries (Craiova). 2018 Apr 12;6(1):e82. doi: 10.15190/d.2018.2. PMID- 34955072 OWN - NLM STAT- MEDLINE DCOM- 20220418 LR - 20220616 IS - 1541-3772 (Electronic) IS - 1048-2911 (Linking) VI - 32 IP - 1 DP - 2022 May TI - HIV and TB Workplace Program for Street Vendors: A Situational Analysis. PG - 30-39 LID - 10.1177/10482911211069621 [doi] AB - In South Africa, 15 percent of informal economy workers are street vendors. The organization of occupational health services in the country is fragmented and does not cover informal workers. Conditions of work make informal workers extremely vulnerable to human immunodeficiency virus (HIV) and tuberculosis (TB) exposure. In this study, a qualitative risk assessment was conducted among street vendors, followed by focus group discussions. Interpretation of data was according to major themes extracted from discussions. Workers are exposed to several occupational health hazards identified during the risk assessment. There is a lack of workplace HIV and TB services and overall poor access to healthcare. Street vendors, especially females, are at higher risk of HIV, due to gender inequalities. Comprehensive gender-sensitive training on occupational health and safety, HIV, and TB should be prioritized. To reach Universal Health Coverage and achieve the Sustainable Developmental Goals' targets, the health system should improve services for informal economy workers. FAU - Mlangeni, Nosimilo AU - Mlangeni N AUID- ORCID: 0000-0003-4130-7001 AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. FAU - Du Preez, Karen AU - Du Preez K AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. FAU - Mokone, Moses AU - Mokone M AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. FAU - Malotle, Molebogeng AU - Malotle M AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. FAU - Kisting, Sophia AU - Kisting S AD - Independent Occupational Medicine Specialist, Cape Town, South Africa. FAU - Ramodike, Jonathan AU - Ramodike J AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. AD - School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. FAU - Zungu, Muzimkhulu AU - Zungu M AD - National Institute for Occupational Health, Johannesburg, Gauteng, South Africa. AD - School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa. LA - eng PT - Journal Article DEP - 20211227 PL - United States TA - New Solut JT - New solutions : a journal of environmental and occupational health policy : NS JID - 9100937 SB - IM MH - Female MH - Focus Groups MH - *HIV Infections/epidemiology/prevention & control MH - Humans MH - *Occupational Health MH - *Occupational Health Services MH - Workplace OTO - NOTNLM OT - HIV and TB workplace program OT - Occupational health and safety OT - access to occupational health services OT - informal workers OT - street vendors OT - worker's health EDAT- 2021/12/28 06:00 MHDA- 2022/04/19 06:00 CRDT- 2021/12/27 05:30 PHST- 2021/12/28 06:00 [pubmed] PHST- 2022/04/19 06:00 [medline] PHST- 2021/12/27 05:30 [entrez] AID - 10.1177/10482911211069621 [doi] PST - ppublish SO - New Solut. 2022 May;32(1):30-39. doi: 10.1177/10482911211069621. Epub 2021 Dec 27. PMID- 28343408 OWN - NLM STAT- MEDLINE DCOM- 20170619 LR - 20170619 IS - 1941-9260 (Electronic) IS - 0032-5481 (Linking) VI - 129 IP - 4 DP - 2017 May TI - Safety of oral direct acting antiviral regimens for chronic hepatitis C in real life conditions. PG - 476-483 LID - 10.1080/00325481.2017.1311197 [doi] AB - OBJECTIVES: Direct acting antivirals (DAA) are extremely effective to treat chronic hepatitis C. The aim of this study was to evaluate, by using objective variables, the safety of DAA combinations under clinical practice conditions. METHODS: A retrospective study was carried out in mono-infected patients with chronic hepatitis C treated with DAA between January and December 2015 in our centre. Discontinuations, treatment modifications, deaths and laboratory parameters were studied (liver function tests, hemoglobin, creatinine and lipid profile at baseline, weeks 4, 8 and post 12). Temporal variation of laboratory parameters was analyzed by t-test for paired data, and comparison between groups was made by t-test for independent samples and ANOVA. RESULTS: 227 patients were included (40.5% cirrhotic). Sustained virological response (SVR) was achieved in 97.3% of patients. In only one case was the antiviral medication suspended due to toxicity, and there were no voluntary treatment discontinuations. The use of ribavirin (RBV) was associated with mild transient hyperbilirubinemia (41.2%) and anemia (32.6%, with RBV dose reduction in 7.9% of cases). There was an elevation in total cholesterol and LDL-cholesterol (LDL-C) during and after treatment: mean increase of 23 mg/dL (0.59 mmol/L) and 22 mg/dL (0.57 mmol/L), respectively in post 12 (p < .0001). An increment of 20% of patients with cholesterol levels over optimal figures was observed after DAA completion. CONCLUSION: DAA have an optimum safety profile in real life conditions, with infrequent discontinuation and minor laboratory alterations. FAU - Juanbeltz, Regina AU - Juanbeltz R AD - a Department of Pharmacy , Complejo Hospitalario de Navarra , Pamplona , Spain. AD - b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. FAU - Goñi Esarte, Silvia AU - Goñi Esarte S AD - d Liver Unit, Department of Gastroenterology , Complejo Hospitalario de Navarra , Pamplona , Spain. FAU - Úriz-Otano, Juan Isidro AU - Úriz-Otano JI AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. AD - d Liver Unit, Department of Gastroenterology , Complejo Hospitalario de Navarra , Pamplona , Spain. FAU - Martínez Echeverría, Ana AU - Martínez Echeverría A AD - d Liver Unit, Department of Gastroenterology , Complejo Hospitalario de Navarra , Pamplona , Spain. FAU - Elizalde, Inmaculada AU - Elizalde I AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. AD - d Liver Unit, Department of Gastroenterology , Complejo Hospitalario de Navarra , Pamplona , Spain. FAU - Zozaya, José Manuel AU - Zozaya JM AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. AD - d Liver Unit, Department of Gastroenterology , Complejo Hospitalario de Navarra , Pamplona , Spain. FAU - Castilla, Jesús AU - Castilla J AD - b CIBER Epidemiología y Salud Pública (CIBERESP) , Madrid , Spain. AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. AD - e Instituto de Salud Pública de Navarra , Pamplona , Spain. FAU - San Miguel, Ramón AU - San Miguel R AD - a Department of Pharmacy , Complejo Hospitalario de Navarra , Pamplona , Spain. AD - c Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Pamplona , Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20170410 PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 RN - 0 (Antiviral Agents) RN - 0 (Drug Combinations) SB - IM MH - Administration, Oral MH - Antiviral Agents/administration & dosage/*therapeutic use MH - Drug Combinations MH - Drug Monitoring MH - Drug Therapy, Combination MH - Female MH - Genotype MH - Hepatitis C, Chronic/*drug therapy/genetics MH - Humans MH - Liver Cirrhosis/complications MH - Liver Function Tests MH - Male MH - Middle Aged MH - Retrospective Studies MH - Spain MH - Treatment Outcome OTO - NOTNLM OT - Antiviral agents OT - cholesterol OT - chronic hepatitis C OT - direct acting antiviral OT - drug monitoring OT - drug safety OT - ribavirin EDAT- 2017/03/28 06:00 MHDA- 2017/06/20 06:00 CRDT- 2017/03/28 06:00 PHST- 2017/03/28 06:00 [pubmed] PHST- 2017/06/20 06:00 [medline] PHST- 2017/03/28 06:00 [entrez] AID - 10.1080/00325481.2017.1311197 [doi] PST - ppublish SO - Postgrad Med. 2017 May;129(4):476-483. doi: 10.1080/00325481.2017.1311197. Epub 2017 Apr 10. PMID- 39738105 OWN - NLM STAT- MEDLINE DCOM- 20241231 LR - 20250104 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 15 IP - 1 DP - 2024 Dec 30 TI - Heat stable and intrinsically sterile liquid protein formulations. PG - 10897 LID - 10.1038/s41467-024-55304-9 [doi] LID - 10897 AB - Over 80% of biologic drugs, and 90% of vaccines, require temperature-controlled conditions throughout the supply chain to minimize thermal inactivation and contamination. This cold chain is costly, requires stringent oversight, and is impractical in remote environments. Here, we report chemical dispersants that non-covalently solvate proteins within fluorous liquids to alter their thermodynamic equilibrium and reduce conformational flexibility. This generates non-aqueous, fluorine-based liquid protein formulations that biochemically rigidify protein structure to yield thermally stable biologics at extreme temperatures (up to 90 °C). These non-aqueous formulations are impervious to contamination by microorganismal pathogens, degradative enzymes, and environmental impurities, and display comparable pre-clinical pharmacokinetics and safety profiles to standard saline protein samples. As a result, we deliver a fluorochemical formulation paradigm that may limit the need for cold chain logistics of protein reagents and biopharmaceuticals. CI - © 2024. The Author(s). FAU - Lawanprasert, Atip AU - Lawanprasert A AUID- ORCID: 0009-0001-3163-8803 AD - Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA. FAU - Singh, Harminder AU - Singh H AUID- ORCID: 0000-0001-9261-6651 AD - Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA. FAU - Pimcharoen, Sopida AU - Pimcharoen S AD - Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA. FAU - Vargas, Mariangely González AU - Vargas MG AD - Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA. FAU - Dewan, Arshiya AU - Dewan A AD - Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA. AD - Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA, USA. FAU - Kirimanjeswara, Girish S AU - Kirimanjeswara GS AUID- ORCID: 0000-0002-9216-1105 AD - Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA. AD - Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA, USA. AD - Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA. AD - Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA. FAU - Medina, Scott H AU - Medina SH AUID- ORCID: 0000-0001-5441-2164 AD - Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA. shm126@psu.edu. AD - Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA. shm126@psu.edu. LA - eng GR - 1845053/National Science Foundation (NSF)/ GR - 1R35-GM142902/U.S. Department of Health & Human Services | National Institutes of Health (NIH)/ GR - D21AP10182/United States Department of Defense | Defense Advanced Research Projects Agency (DARPA)/ PT - Journal Article DEP - 20241230 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 0 (Proteins) SB - IM MH - *Hot Temperature MH - Animals MH - Protein Stability MH - Proteins/chemistry MH - Humans MH - Thermodynamics MH - Mice MH - Chemistry, Pharmaceutical/methods PMC - PMC11685576 COIS- Competing interests: The authors declare no competing interests. EDAT- 2024/12/31 12:21 MHDA- 2024/12/31 12:22 PMCR- 2024/12/30 CRDT- 2024/12/31 11:33 PHST- 2023/10/13 00:00 [received] PHST- 2024/12/09 00:00 [accepted] PHST- 2024/12/31 12:22 [medline] PHST- 2024/12/31 12:21 [pubmed] PHST- 2024/12/31 11:33 [entrez] PHST- 2024/12/30 00:00 [pmc-release] AID - 10.1038/s41467-024-55304-9 [pii] AID - 55304 [pii] AID - 10.1038/s41467-024-55304-9 [doi] PST - epublish SO - Nat Commun. 2024 Dec 30;15(1):10897. doi: 10.1038/s41467-024-55304-9. PMID- 33188430 OWN - NLM STAT- MEDLINE DCOM- 20210520 LR - 20210520 IS - 1465-3664 (Electronic) IS - 0142-6338 (Print) IS - 0142-6338 (Linking) VI - 67 IP - 1 DP - 2021 Jan 29 TI - Safety and Ethics in Endoscopic Studies in Children: Evidence From the BEECH Study in Zambia. LID - 10.1093/tropej/fmaa074 [doi] LID - fmaa074 AB - BACKGROUND: Environmental enteropathy is an example of a poorly-understood intestinal disorder affecting millions of children worldwide, characterized by malabsorption and stunting. Although there is increasing interest in non-invasive means of assessing intestinal structure and function, the potential value of intestinal biopsy for histology, immunostaining, RNA sequencing and epigenetic work means that endoscopic biopsy remains extremely valuable. We here report our experience in the BEECH (Biomarkers of Environmental Enteropathy in CHildren) study of stunting in Zambia, in the belief that it may help address the knowledge gap regarding the safety of endoscopic biopsy in vulnerable young children. METHODS: We report our experience of safety in 119 children undergoing endoscopic biopsy in the BEECH study in Lusaka Children's Hospital, Lusaka, and discuss ethical considerations in this light. RESULTS: Upper gastrointestinal endoscopy was performed on children with stunting (length-for-age z score -2 or less) not responsive to nutritional interventions. Conscious sedation was provided by anaesthetists. Of 119 children, 5 (4%) developed transient desaturation, but no serious adverse events were experienced; no clinical, demographic or anaesthetic characteristics were identified as predictive of desaturation. Two children derived clinically useful information from the endoscopy, one life-saving. Of 105 lactase tests, 59 (54%) showed hypolactasia. DISCUSSION: Children with stunting underwent endoscopy safely, and some derived clinical benefit. Safety and the possibility of clinical benefit are usually felt to be preconditions for the ethical justification for endoscopy for research in children, and we believe that these conditions were met in this study. CI - © The Author(s) [2020]. Published by Oxford University Press. FAU - Chandwe, Kanta AU - Chandwe K AD - Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, 10101 Lusaka, Zambia. FAU - Amadi, Beatrice AU - Amadi B AD - Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, 10101 Lusaka, Zambia. FAU - Chipunza, Miyoba AU - Chipunza M AD - Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, 10101 Lusaka, Zambia. FAU - Zyambo, Masuzyo AU - Zyambo M AD - Department of Anaesthesia, University of Zambia School of Medicine, 10101 Lusaka, Zambia. FAU - Kelly, Paul AU - Kelly P AD - Tropical Gastroenterology & Nutrition group, University of Zambia School of Medicine, 10101 Lusaka, Zambia. AD - Barts & The London School of Medicine, Queen Mary University of London, London E1 2AT, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Trop Pediatr JT - Journal of tropical pediatrics JID - 8010948 RN - 0 (Biomarkers) SB - IM MH - Biomarkers MH - Biopsy MH - Child MH - Child, Preschool MH - *Fagus MH - Growth Disorders MH - Humans MH - Zambia/epidemiology PMC - PMC7948385 EDAT- 2020/11/15 06:00 MHDA- 2021/05/21 06:00 PMCR- 2020/11/14 CRDT- 2020/11/14 05:29 PHST- 2020/11/15 06:00 [pubmed] PHST- 2021/05/21 06:00 [medline] PHST- 2020/11/14 05:29 [entrez] PHST- 2020/11/14 00:00 [pmc-release] AID - 5981785 [pii] AID - fmaa074 [pii] AID - 10.1093/tropej/fmaa074 [doi] PST - ppublish SO - J Trop Pediatr. 2021 Jan 29;67(1):fmaa074. doi: 10.1093/tropej/fmaa074. PMID- 39075440 OWN - NLM STAT- MEDLINE DCOM- 20240730 LR - 20250129 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 24 IP - 1 DP - 2024 Jul 29 TI - Inexperienced water users can "Float to Live" in realistic open water conditions. PG - 2030 LID - 10.1186/s12889-024-19409-6 [doi] LID - 2030 AB - BACKGROUND: The RNLI "Float to Live" campaign is based on research conducted in indoor pools with experienced open water swimmers. Study 1 investigated whether the RNLI "Float to Live" guidance would enable less experienced individuals to float in realistic open water conditions. Study 2 examined the separate effects of practice and coaching on floating competence. METHODS: Study 1: Inexperienced water users conducted floats in either still, open fresh (n = 22) or open sea water (n = 13), followed by moving sea (n = 6) or fresh water (n = 5). Participants undertook three 2-min floats in still water wearing swimwear and one clothed float: 1) naïve; 2) following RNLI "Float to live" messaging; 3) individual float coaching; 4) simulated fall wearing summer clothing. In moving sea water, participants undertook two floats equivalent to Floats 3 and 4. In moving fresh water, participants undertook 3 floats: 1) naïve; 2) following "defensive floating" coaching; 3) simulated fall wearing summer clothing. Study 2: Two groups matched for skinfold thickness undertook three 2-min floats in a flume wearing swimwear. PRAC group (n = 12): 1) naïve; 2) following float practice; 3) float coaching; COACH group (n = 11) coaching followed by practice. Floating difficulty, confidence, competence, "efficiency" and perceived exertion were analysed using either a Friedman test or mixed model ANOVA. RESULTS: In both fresh water and sea water, participants' floating competence and confidence increased after viewing the RNLI messaging, it was further improved with individualised float coaching. The additional helpful instructions included: 1) "head back with ears submerged"; 2) "relax"; 3) "breathe normally"; 4) "it is OK if your legs sink"; 5) an accurate description of sculling for "active" floaters that needed it; 6) spread arms and legs for stability. The simulated fall with clothing did not impair floating competence. No difference in floating competence was seen between PRAC and COACH, though confidence may be increased sooner in COACH. CONCLUSIONS: The RNLI float advice can be applied in realistic open water settings by less experienced water users. Additional content could be included to make the messaging even more effective. CI - © 2024. The Author(s). FAU - Eglin, Clare AU - Eglin C AD - Extreme Environments Laboratory, University of Portsmouth, Portsmouth, UK. clare.eglin@port.ac.uk. FAU - Massey, Heather AU - Massey H AD - Extreme Environments Laboratory, University of Portsmouth, Portsmouth, UK. FAU - Long, Geoff AU - Long G AD - Extreme Environments Laboratory, University of Portsmouth, Portsmouth, UK. FAU - Mayhew, Adrian AU - Mayhew A AD - Surf Life Saving GB, Exeter, UK. FAU - Tipton, Michael AU - Tipton M AD - Extreme Environments Laboratory, University of Portsmouth, Portsmouth, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240729 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - *Swimming MH - Swimming Pools MH - Young Adult MH - Fresh Water PMC - PMC11285178 OTO - NOTNLM OT - Drowning prevention OT - Floating OT - Water immersion OT - Water safety COIS- The authors declare no competing interests. EDAT- 2024/07/30 00:42 MHDA- 2024/07/30 06:42 PMCR- 2024/07/29 CRDT- 2024/07/29 23:47 PHST- 2024/04/24 00:00 [received] PHST- 2024/07/08 00:00 [accepted] PHST- 2024/07/30 06:42 [medline] PHST- 2024/07/30 00:42 [pubmed] PHST- 2024/07/29 23:47 [entrez] PHST- 2024/07/29 00:00 [pmc-release] AID - 10.1186/s12889-024-19409-6 [pii] AID - 19409 [pii] AID - 10.1186/s12889-024-19409-6 [doi] PST - epublish SO - BMC Public Health. 2024 Jul 29;24(1):2030. doi: 10.1186/s12889-024-19409-6. PMID- 9328500 OWN - NLM STAT- MEDLINE DCOM- 19971028 LR - 20241219 IS - 0007-1250 (Print) IS - 0007-1250 (Linking) VI - 171 DP - 1997 Jul TI - Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study. PG - 73-7 AB - BACKGROUND: Acamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions. METHOD: In order to assess the efficacy and safety of the drug in the treatment of detoxified alcoholics, we performed a 90-day double-blind trial comparing two dosages of acamprosate (1332 mg/day and 1998 mg/day). RESULTS: For all efficacy parameters, acamprosate appeared to be significantly superior to placebo, with a trend towards a better effect at the higher dosage. Furthermore, acamprosate appeared to be extremely safe. CONCLUSION: This study confirms that acamprosate could be an interesting adjuvant for maintaining abstinence in detoxified alcoholics. FAU - Pelc, I AU - Pelc I AD - Psychiatry Department, Brugmann University Hospital, Brussels, Belgium. FAU - Verbanck, P AU - Verbanck P FAU - Le Bon, O AU - Le Bon O FAU - Gavrilovic, M AU - Gavrilovic M FAU - Lion, K AU - Lion K FAU - Lehert, P AU - Lehert P LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Br J Psychiatry JT - The British journal of psychiatry : the journal of mental science JID - 0342367 RN - 0 (Alcohol Deterrents) RN - 1EQV5MLY3D (Taurine) RN - N4K14YGM3J (Acamprosate) SB - IM MH - Acamprosate MH - Adolescent MH - Adult MH - Aged MH - Alcohol Deterrents/adverse effects/*therapeutic use MH - Alcoholism/*drug therapy MH - Diarrhea/chemically induced MH - Dose-Response Relationship, Drug MH - Double-Blind Method MH - Female MH - Humans MH - Libido/drug effects MH - Male MH - Middle Aged MH - Recurrence MH - Taurine/adverse effects/*analogs & derivatives/therapeutic use MH - Temperance MH - Treatment Outcome EDAT- 1997/07/01 00:00 MHDA- 1997/11/05 00:01 CRDT- 1997/07/01 00:00 PHST- 1997/07/01 00:00 [pubmed] PHST- 1997/11/05 00:01 [medline] PHST- 1997/07/01 00:00 [entrez] AID - S0007125000147233 [pii] AID - 10.1192/bjp.171.1.73 [doi] PST - ppublish SO - Br J Psychiatry. 1997 Jul;171:73-7. doi: 10.1192/bjp.171.1.73. PMID- 17519062 OWN - NLM STAT- MEDLINE DCOM- 20070726 LR - 20190911 IS - 1473-4877 (Electronic) IS - 0300-7995 (Linking) VI - 23 IP - 5 DP - 2007 May TI - Perindopril arginine: benefits of a new salt of the ACE inhibitor perindopril. PG - 953-60 AB - BACKGROUND: The efficacy of the angiotensin-converting enzyme (ACE) inhibitor perindopril in the treatment of hypertension, stable coronary artery disease, and heart failure is well established. The reduced stability of the current salt, perindopril-tert-butylamine, in extreme climatic conditions has prompted research into more stable compounds. This article presents stability and bioequivalence results for a new L-arginine salt of perindopril. METHODS: Drug stability studies were performed on nonsalified perindopril, perindopril-tert-butylamine, and perindopril arginine in closed and open containers. The bioequivalence of perindopril arginine was tested in 36 healthy male volunteers in an open-label, randomized, two-period, crossover pharmacokinetic study. A consumer study was carried out in 120 patients to assess preference for a simplified packaging using a high-density polyethylene canister designed for distribution to all climatic zones. RESULTS AND DISCUSSION: Perindopril arginine is 50% more stable than perindopril-tert-butylamine, which increases the shelf life from 2 to 3 years. At the revised dosage (perindopril arginine 5-10 mg/day corresponds to perindopril-tert-butylamine 4-8 mg/day), the new salt is equivalent in terms of pharmacokinetics, efficacy, safety, and acceptability. The consumer studies indicate a preference for the new packaging, with 62% of patients nominating the canister as better than the blister packs. CONCLUSION: The new perindopril arginine salt is equivalent to perindopril-tert-butylamine and more stable, and can be distributed to climatic zones III and IV without the need for specific packaging. The patient preference for the new packaging could have positive implications for compliance. FAU - Telejko, Elwira AU - Telejko E AD - Studium Kształcenia Podyplomowego, Białystok, Poland. ztpl@amb.edu.pl LA - eng PT - Comparative Study PT - Journal Article PT - Review PL - England TA - Curr Med Res Opin JT - Current medical research and opinion JID - 0351014 RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - Y5GMK36KGY (Perindopril) SB - IM MH - Angiotensin-Converting Enzyme Inhibitors/adverse effects/chemistry/pharmacokinetics/*therapeutic use MH - Climate MH - Drug Evaluation MH - Drug Packaging MH - Drug Stability MH - Geography MH - Humans MH - Models, Biological MH - Patient Acceptance of Health Care MH - Perindopril/adverse effects/chemistry/pharmacokinetics/*therapeutic use MH - Risk Assessment MH - Therapeutic Equivalency RF - 30 EDAT- 2007/05/24 09:00 MHDA- 2007/07/27 09:00 CRDT- 2007/05/24 09:00 PHST- 2007/05/24 09:00 [pubmed] PHST- 2007/07/27 09:00 [medline] PHST- 2007/05/24 09:00 [entrez] AID - 10.1185/030079907x182158 [doi] PST - ppublish SO - Curr Med Res Opin. 2007 May;23(5):953-60. doi: 10.1185/030079907x182158. PMID- 19608002 OWN - NLM STAT- MEDLINE DCOM- 20090910 LR - 20121115 IS - 0074-7742 (Print) IS - 0074-7742 (Linking) VI - 86 DP - 2009 TI - Brain-machine interfaces for space applications-research, technological development, and opportunities. PG - 213-23 LID - 10.1016/S0074-7742(09)86016-9 [doi] AB - Recent advances in brain research and brain-machine interfaces suggest these devices could play a central role in future generation computer interfaces. Successes in the use of brain machine interfaces for patients affected by motor paralysis, as well as first developments of games and gadgets based on this technology have matured the field and brought brain-machine interfaces to the brink of more general usability and eventually of opening new markets. In human space flight, astronauts are the most precious "payload" and astronaut time is extremely valuable. Astronauts operate under difficult and unusual conditions since the absence of gravity renders some of the very simple tasks tedious and cumbersome. Therefore, computer interfaces are generally designed for safety and functionality. All improvements and technical aids to enhance their functionality and efficiency, while not compromising safety or overall mass requirements, are therefore of great interest. Brain machine interfaces show some interesting properties in this respect. It is however not obvious that devices developed for functioning on-ground can be used as hands-free interfaces for astronauts. This chapter intends to highlight the research directions of brain machine interfaces with the perceived highest potential impact on future space applications, and to present an overview of the long-term plans with respect to human space flight. We conclude by suggesting research and development steps considered necessary to include brain-machine interface technology in future architectures for human space flight. FAU - Summerer, Leopold AU - Summerer L AD - Advanced Concepts Team, European Space Agency, Keplerlaan 1, 2201 AZ Noordwijk, The Netherlands. FAU - Izzo, Dario AU - Izzo D FAU - Rossini, Luca AU - Rossini L LA - eng PT - Journal Article PL - United States TA - Int Rev Neurobiol JT - International review of neurobiology JID - 0374740 SB - IM MH - Brain/*physiology MH - Humans MH - *Man-Machine Systems MH - *Research/trends MH - Research Design MH - Space Flight/*instrumentation MH - United States MH - United States National Aeronautics and Space Administration MH - *User-Computer Interface EDAT- 2009/07/18 09:00 MHDA- 2009/09/11 06:00 CRDT- 2009/07/18 09:00 PHST- 2009/07/18 09:00 [entrez] PHST- 2009/07/18 09:00 [pubmed] PHST- 2009/09/11 06:00 [medline] AID - S0074-7742(09)86016-9 [pii] AID - 10.1016/S0074-7742(09)86016-9 [doi] PST - ppublish SO - Int Rev Neurobiol. 2009;86:213-23. doi: 10.1016/S0074-7742(09)86016-9. PMID- 37754081 OWN - NLM STAT- Publisher LR - 20231003 IS - 2079-6374 (Electronic) IS - 2079-6374 (Linking) VI - 13 IP - 9 DP - 2023 Aug 25 TI - Zeolitic Imidazolate Framework-8 Composite-Based Enzyme-Linked Aptamer Assay for the Sensitive Detection of Deoxynivalenol. LID - 10.3390/bios13090847 [doi] LID - 847 AB - The mycotoxin deoxynivalenol (DON) is a prevalent contaminant in cereals that threatens the health of both humans and animals and causes economic losses due to crop contamination. The rapid and sensitive detection of DON is essential for food safety. Herein, a colorimetric biosensor based on horseradish peroxidase- and gold nanoparticle-encapsulated zeolitic imidazolate framework-8 (HRP&Au@ZIF-8) was developed for the sensitive screening of DON. The synthesized HRP&Au@ZIF-8 probes not only held great potential for signal amplification but also exhibited stable catalytic activity even under extreme conditions, which endowed the biosensor with both good sensitivity and stability. Under the optimized conditions, qualitative measurement of DON can be achieved through visual inspection, and quantitative evaluation can be performed via absorbance measurements at a characteristic wavelength of 450 nm. The proposed method has demonstrated high sensitivity with a linear detection range of 1-200 ng/mL and a detection limit of 0.5068 ng/mL. It also presented good selectivity and reliability. Furthermore, DON in spiked cereal samples has been quantified successfully using this method. This novel approach demonstrates significant potential for the facile and expeditious detection of DON in cereal products and brings us one step closer to enhancing food safety. FAU - Shu, Zaixi AU - Shu Z AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory for Deep Processing of Major Grain and Oil, Wuhan Polytechnic University, Ministry of Education, Wuhan 430023, China. FAU - Zhou, Run AU - Zhou R AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory for Deep Processing of Major Grain and Oil, Wuhan Polytechnic University, Ministry of Education, Wuhan 430023, China. FAU - Hao, Guijie AU - Hao G AD - Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Health and Nutrition of Zhejiang Province, Huzhou Key Laboratory of Aquatic Product Quality Improvement and Processing Technology, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China. FAU - Tang, Xingyue AU - Tang X AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Health and Nutrition of Zhejiang Province, Huzhou Key Laboratory of Aquatic Product Quality Improvement and Processing Technology, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China. FAU - Liu, Xin AU - Liu X AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory for Deep Processing of Major Grain and Oil, Wuhan Polytechnic University, Ministry of Education, Wuhan 430023, China. FAU - Bi, Jie AU - Bi J AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory for Deep Processing of Major Grain and Oil, Wuhan Polytechnic University, Ministry of Education, Wuhan 430023, China. FAU - Dai, Huang AU - Dai H AD - College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China. AD - Key Laboratory for Deep Processing of Major Grain and Oil, Wuhan Polytechnic University, Ministry of Education, Wuhan 430023, China. FAU - Shen, Yafang AU - Shen Y AUID- ORCID: 0000-0003-3355-9516 AD - Key Laboratory of Healthy Freshwater Aquaculture, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Health and Nutrition of Zhejiang Province, Huzhou Key Laboratory of Aquatic Product Quality Improvement and Processing Technology, Zhejiang Institute of Freshwater Fisheries, Huzhou 313001, China. LA - eng GR - NO2022YFF1102500/National Key Research and Development Program of China/ PT - Journal Article DEP - 20230825 PL - Switzerland TA - Biosensors (Basel) JT - Biosensors JID - 101609191 SB - IM PMC - PMC10526248 OTO - NOTNLM OT - biomimetic mineralization OT - colorimetric detection OT - deoxynivalenol OT - enzyme-linked aptamer assay OT - zeolitic imidazolate framework-8 COIS- The authors declare no conflict of interest. EDAT- 2023/09/27 12:42 MHDA- 2023/09/27 12:42 PMCR- 2023/08/25 CRDT- 2023/09/27 08:43 PHST- 2023/07/25 00:00 [received] PHST- 2023/08/20 00:00 [revised] PHST- 2023/08/23 00:00 [accepted] PHST- 2023/09/27 12:42 [medline] PHST- 2023/09/27 12:42 [pubmed] PHST- 2023/09/27 08:43 [entrez] PHST- 2023/08/25 00:00 [pmc-release] AID - bios13090847 [pii] AID - biosensors-13-00847 [pii] AID - 10.3390/bios13090847 [doi] PST - epublish SO - Biosensors (Basel). 2023 Aug 25;13(9):847. doi: 10.3390/bios13090847. PMID- 24690938 OWN - NLM STAT- MEDLINE DCOM- 20150309 LR - 20141206 IS - 0048-7554 (Print) IS - 0048-7554 (Linking) VI - 29 IP - 4 DP - 2014 TI - Understanding exposure from natural gas drilling puts current air standards to the test. PG - 277-92 LID - 10.1515/reveh-2014-0002 [doi] AB - Case study descriptions of acute onset of respiratory, neurologic, dermal, vascular, abdominal, and gastrointestinal sequelae near natural gas facilities contrast with a subset of emissions research, which suggests that there is limited risk posed by unconventional natural gas development (UNGD). An inspection of the pathophysiological effects of acute toxic actions reveals that current environmental monitoring protocols are incompatible with the goal of protecting the health of those living and working near UNGD activities. The intensity, frequency, and duration of exposures to toxic materials in air and water determine the health risks to individuals within a population. Currently, human health risks near UNGD sites are derived from average population risks without adequate attention to the processes of toxicity to the body. The objective of this paper is to illustrate that current methods of collecting emissions data, as well as the analyses of these data, are not sufficient for accurately assessing risks to individuals or protecting the health of those near UNGD sites. Focusing on air pollution impacts, we examined data from public sources and from the published literature. We compared the methods commonly used to evaluate health safety near UNGD sites with the information that would be reasonably needed to determine plausible outcomes of actual exposures. Such outcomes must be based on the pathophysiological effects of the agents present and the susceptibility of residents near these sites. Our study has several findings. First, current protocols used for assessing compliance with ambient air standards do not adequately determine the intensity, frequency or durations of the actual human exposures to the mixtures of toxic materials released regularly at UNGD sites. Second, the typically used periodic 24-h average measures can underestimate actual exposures by an order of magnitude. Third, reference standards are set in a form that inaccurately determines health risk because they do not fully consider the potential synergistic combinations of toxic air emissions. Finally, air dispersion modeling shows that local weather conditions are strong determinates of individual exposures. Appropriate estimation of safety requires nested protocols that measure real time exposures. New protocols are needed to provide 1) continuous measures of a surrogate compound to show periods of extreme exposure; 2) a continuous screening model based on local weather conditions to warn of periodic high exposures; and 3) comprehensive detection of chemical mixtures using canisters or other devices that capture the major components of the mixtures. FAU - Brown, David AU - Brown D FAU - Weinberger, Beth AU - Weinberger B FAU - Lewis, Celia AU - Lewis C FAU - Bonaparte, Heather AU - Bonaparte H LA - eng PT - Journal Article PT - Review PL - Germany TA - Rev Environ Health JT - Reviews on environmental health JID - 0425754 RN - 0 (Air Pollutants) RN - 0 (Natural Gas) SB - IM MH - Air Pollutants/analysis MH - Environmental Exposure MH - Humans MH - *Natural Gas MH - Public Health MH - Public Policy MH - Quality of Life MH - *Research MH - Vulnerable Populations MH - Water Quality EDAT- 2014/04/03 06:00 MHDA- 2015/03/10 06:00 CRDT- 2014/04/03 06:00 PHST- 2014/01/06 00:00 [received] PHST- 2014/02/14 00:00 [accepted] PHST- 2014/04/03 06:00 [entrez] PHST- 2014/04/03 06:00 [pubmed] PHST- 2015/03/10 06:00 [medline] AID - /j/reveh.ahead-of-print/reveh-2014-0002/reveh-2014-0002.xml [pii] AID - 10.1515/reveh-2014-0002 [doi] PST - ppublish SO - Rev Environ Health. 2014;29(4):277-92. doi: 10.1515/reveh-2014-0002. PMID- 34067778 OWN - NLM STAT- MEDLINE DCOM- 20210622 LR - 20210622 IS - 1420-3049 (Electronic) IS - 1420-3049 (Linking) VI - 26 IP - 10 DP - 2021 May 17 TI - Strategies for Natural Products Discovery from Uncultured Microorganisms. LID - 10.3390/molecules26102977 [doi] LID - 2977 AB - Microorganisms are highly regarded as a prominent source of natural products that have significant importance in many fields such as medicine, farming, environmental safety, and material production. Due to this, only tiny amounts of microorganisms can be cultivated under standard laboratory conditions, and the bulk of microorganisms in the ecosystems are still unidentified, which restricts our knowledge of uncultured microbial metabolism. However, they could hypothetically provide a large collection of innovative natural products. Culture-independent metagenomics study has the ability to address core questions in the potential of NP production by cloning and analysis of microbial DNA derived directly from environmental samples. Latest advancements in next generation sequencing and genetic engineering tools for genome assembly have broadened the scope of metagenomics to offer perspectives into the life of uncultured microorganisms. In this review, we cover the methods of metagenomic library construction, and heterologous expression for the exploration and development of the environmental metabolome and focus on the function-based metagenomics, sequencing-based metagenomics, and single-cell metagenomics of uncultured microorganisms. FAU - Alam, Khorshed AU - Alam K AUID- ORCID: 0000-0002-6003-6991 AD - Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. FAU - Abbasi, Muhammad Nazeer AU - Abbasi MN AD - Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. FAU - Hao, Jinfang AU - Hao J AD - Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. FAU - Zhang, Youming AU - Zhang Y AD - Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. FAU - Li, Aiying AU - Li A AUID- ORCID: 0000-0002-6732-921X AD - Helmholtz International Lab for Anti-Infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. LA - eng GR - No. 2019YFA0905700, 2018YFA0900400/National Key R&D Program of China/ PT - Journal Article PT - Review DEP - 20210517 PL - Switzerland TA - Molecules JT - Molecules (Basel, Switzerland) JID - 100964009 RN - 0 (Biological Products) SB - IM MH - Bacteria/genetics/*metabolism MH - Biological Products/*isolation & purification/pharmacology MH - Ecosystem MH - High-Throughput Nucleotide Sequencing/methods MH - Metagenome/genetics MH - Metagenomics/*methods PMC - PMC8156983 OTO - NOTNLM OT - eDNA OT - environmental metabolome OT - extreme ecosystem OT - heterologous expression OT - metagenomics OT - microbial dark matter OT - natural products OT - single cell sequencing OT - uncultured microorganisms COIS- The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. EDAT- 2021/06/03 06:00 MHDA- 2021/06/23 06:00 PMCR- 2021/05/17 CRDT- 2021/06/02 01:20 PHST- 2021/03/23 00:00 [received] PHST- 2021/05/13 00:00 [revised] PHST- 2021/05/13 00:00 [accepted] PHST- 2021/06/02 01:20 [entrez] PHST- 2021/06/03 06:00 [pubmed] PHST- 2021/06/23 06:00 [medline] PHST- 2021/05/17 00:00 [pmc-release] AID - molecules26102977 [pii] AID - molecules-26-02977 [pii] AID - 10.3390/molecules26102977 [doi] PST - epublish SO - Molecules. 2021 May 17;26(10):2977. doi: 10.3390/molecules26102977. PMID- 33168752 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240330 IS - 1091-6490 (Electronic) IS - 0027-8424 (Print) IS - 0027-8424 (Linking) VI - 117 IP - 47 DP - 2020 Nov 24 TI - Underpotential lithium plating on graphite anodes caused by temperature heterogeneity. PG - 29453-29461 LID - 10.1073/pnas.2009221117 [doi] AB - Rechargeability and operational safety of commercial lithium (Li)-ion batteries demand further improvement. Plating of metallic Li on graphite anodes is a critical reason for Li-ion battery capacity decay and short circuit. It is generally believed that Li plating is caused by the slow kinetics of graphite intercalation, but in this paper, we demonstrate that thermodynamics also serves a crucial role. We show that a nonuniform temperature distribution within the battery can make local plating of Li above 0 V vs. Li(0)/Li(+) (room temperature) thermodynamically favorable. This phenomenon is caused by temperature-dependent shifts of the equilibrium potential of Li(0)/Li(+) Supported by simulation results, we confirm the likelihood of this failure mechanism during commercial Li-ion battery operation, including both slow and fast charging conditions. This work furthers the understanding of nonuniform Li plating and will inspire future studies to prolong the cycling lifetime of Li-ion batteries. FAU - Wang, Hansen AU - Wang H AUID- ORCID: 0000-0002-6738-1659 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Zhu, Yangying AU - Zhu Y AUID- ORCID: 0000-0001-9185-3161 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Kim, Sang Cheol AU - Kim SC AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Pei, Allen AU - Pei A AUID- ORCID: 0000-0001-8930-2125 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Li, Yanbin AU - Li Y AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Boyle, David T AU - Boyle DT AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Wang, Hongxia AU - Wang H AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Zhang, Zewen AU - Zhang Z AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Ye, Yusheng AU - Ye Y AUID- ORCID: 0000-0001-9832-2478 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Huang, William AU - Huang W AUID- ORCID: 0000-0001-8717-5337 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Liu, Yayuan AU - Liu Y AUID- ORCID: 0000-0002-0718-4784 AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Xu, Jinwei AU - Xu J AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Li, Jun AU - Li J AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Liu, Fang AU - Liu F AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305. FAU - Cui, Yi AU - Cui Y AD - Department of Materials Science and Engineering, Stanford University, Stanford, CA 94305; yicui@stanford.edu. AD - Stanford Institute for Materials and Energy Sciences, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025. LA - eng PT - Journal Article DEP - 20201109 PL - United States TA - Proc Natl Acad Sci U S A JT - Proceedings of the National Academy of Sciences of the United States of America JID - 7505876 SB - IM PMC - PMC7703581 OTO - NOTNLM OT - Li plating OT - equilibrium potential OT - extreme fast charging OT - temperature heterogeneity OT - thermodynamics COIS- The authors declare no competing interest. EDAT- 2020/11/11 06:00 MHDA- 2020/11/11 06:01 PMCR- 2021/05/09 CRDT- 2020/11/10 05:39 PHST- 2020/11/11 06:00 [pubmed] PHST- 2020/11/11 06:01 [medline] PHST- 2020/11/10 05:39 [entrez] PHST- 2021/05/09 00:00 [pmc-release] AID - 2009221117 [pii] AID - 202009221 [pii] AID - 10.1073/pnas.2009221117 [doi] PST - ppublish SO - Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29453-29461. doi: 10.1073/pnas.2009221117. Epub 2020 Nov 9. PMID- 36387829 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221119 IS - 2307-8960 (Print) IS - 2307-8960 (Electronic) IS - 2307-8960 (Linking) VI - 10 IP - 31 DP - 2022 Nov 6 TI - Unexplained septic shock after colonoscopy with polyethylene glycol preparation in a young adult: A case report. PG - 11652-11657 LID - 10.12998/wjcc.v10.i31.11652 [doi] AB - BACKGROUND: Colonoscopy has become a routine physical examination as people's health awareness has increased. Polyethylene glycol (PEG) is greatly used in bowel preparation before colonoscopy due to its price and safety advantages. Septic shock after colonoscopy with PEG preparation is extremely rare, with only very few cases in critically ill patients. Herein, we describe a case of septic shock in a healthy young adult immediately following colonoscopy with PEG preparation. CASE SUMMARY: A 33-year-old young adult presented to our hospital for colonoscopy with PEG bowel preparation due to recurrent diarrhea for 7 years. The male's previous physical examination showed no abnormal indicators, and colonoscopy results were normal; however, he exhibited septic shock and markedly elevated white blood cell, C-reactive protein, and procalcitonin levels on the second day after colonoscopy. Immediate resuscitation and intensive care with appropriate antibiotics improved his condition. However, the blood and stool cultures did not detect the pathogen. CONCLUSION: Septic shock after colonoscopy is rare, especially in young adults. The authors considered the possibility of opportunistic infections after PEG bowel preparation, and clinicians should monitor patients for the possibility of such complications. CI - ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Song, Jiao-Jiao AU - Song JJ AD - Department of Gastrointestinal Endoscopy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China. FAU - Wu, Chen-Jiao AU - Wu CJ AD - Department of Gastrointestinal Endoscopy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China. FAU - Dong, Yuan-Yuan AU - Dong YY AD - Department of Gastrointestinal Endoscopy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China. FAU - Ma, Can AU - Ma C AD - Department of Gastrointestinal Endoscopy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China. FAU - Gu, Qing AU - Gu Q AD - Department of Gastrointestinal Endoscopy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China. 21318037@zju.edu.cn. LA - eng PT - Case Reports PT - Journal Article PL - United States TA - World J Clin Cases JT - World journal of clinical cases JID - 101618806 PMC - PMC9649567 OTO - NOTNLM OT - Case report OT - Colonoscopy OT - Polyethylene glycol OT - Septic shock COIS- Conflict-of-interest statement: All the authors declare that they have no conflicts of interest to disclose. EDAT- 2022/11/18 06:00 MHDA- 2022/11/18 06:01 PMCR- 2022/11/06 CRDT- 2022/11/17 12:03 PHST- 2022/07/31 00:00 [received] PHST- 2022/09/15 00:00 [revised] PHST- 2022/09/27 00:00 [accepted] PHST- 2022/11/17 12:03 [entrez] PHST- 2022/11/18 06:00 [pubmed] PHST- 2022/11/18 06:01 [medline] PHST- 2022/11/06 00:00 [pmc-release] AID - 10.12998/wjcc.v10.i31.11652 [doi] PST - ppublish SO - World J Clin Cases. 2022 Nov 6;10(31):11652-11657. doi: 10.12998/wjcc.v10.i31.11652. PMID- 16857284 OWN - NLM STAT- MEDLINE DCOM- 20061120 LR - 20220331 IS - 0168-1605 (Print) IS - 0168-1605 (Linking) VI - 111 IP - 3 DP - 2006 Oct 1 TI - Modelling the individual cell lag time distributions of Listeria monocytogenes as a function of the physiological state and the growth conditions. PG - 241-51 AB - The individual cell lag time distributions of Listeria monocytogenes were characterized for 54 combinations of 22 initial physiological states, 18 growth conditions, and 11 strains. The individual cell lag times were deduced from the times for cultures issued from individual cells to reach an optical density threshold. The extreme value type II distribution with a shape parameter set to 5 was shown effective to describe the 54 observed distributions. The theoretical distributions of individual lag times were thus predictable from the observed means and standard deviations of cell lag times. More interestingly, relationships were proposed to predict the mean and the standard deviation of individual cell lag times from population lag times observed with high initial concentration experiments. The observed relations are consistent with the constancy of the product of the growth rate by the lag time at the cell level for a given physiological state when growth conditions are varying. This product, k, is thus representative of the cell physiological state. The proposed models allow the prediction of individual cell lag time distributions of L. monocytogenes in different growth conditions. We also observed that, whatever the stress encountered and the strains used, the coefficient of variation of the distributions of k was quite constant. These results could be used to describe the variability of the behaviour of few cells of L. monocyotgenes contaminating foods and stressed in the environment of food industry or by food processing. FAU - Guillier, Laurent AU - Guillier L AD - Ecole Nationale Vétérinaire d'Alfort, Unité Microbiologie des Alimente Sécurité Qualité, 7 avenue du Général de Gaulle, F-94704 Maisons-Alfort, France. FAU - Augustin, Jean-Christophe AU - Augustin JC LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060718 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM EIN - Int J Food Microbiol. 2008 May 10;124(1):114 MH - Colony Count, Microbial MH - Consumer Product Safety MH - *Food Contamination/analysis MH - Food Handling/*methods MH - Food Microbiology MH - Humans MH - Kinetics MH - Listeria monocytogenes/*growth & development MH - *Models, Biological MH - Predictive Value of Tests MH - Risk Assessment EDAT- 2006/07/22 09:00 MHDA- 2006/12/09 09:00 CRDT- 2006/07/22 09:00 PHST- 2005/12/02 00:00 [received] PHST- 2006/04/28 00:00 [revised] PHST- 2006/05/27 00:00 [accepted] PHST- 2006/07/22 09:00 [pubmed] PHST- 2006/12/09 09:00 [medline] PHST- 2006/07/22 09:00 [entrez] AID - S0168-1605(06)00312-6 [pii] AID - 10.1016/j.ijfoodmicro.2006.05.011 [doi] PST - ppublish SO - Int J Food Microbiol. 2006 Oct 1;111(3):241-51. doi: 10.1016/j.ijfoodmicro.2006.05.011. Epub 2006 Jul 18. PMID- 18379377 OWN - NLM STAT- MEDLINE DCOM- 20080506 LR - 20210106 IS - 1529-4242 (Electronic) IS - 0032-1052 (Linking) VI - 121 IP - 4 Suppl DP - 2008 Apr TI - MOC-PS(SM) CME article: liposuction. PG - 1-11 LID - 10.1097/01.prs.0000308480.33644.56 [doi] AB - LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Adequately evaluate a patient preoperatively for liposuction. 2. Formulate a surgical treatment plan to safely perform liposuction. 3. Postoperatively diagnose immediate, early, and late complications and formulate a treatment plan for the complications. 4. Classify the anesthesia status of a potential liposuction patient and select the appropriate type of anesthetics to be used. 5. Understand large-volume liposuction and the added risks inherent in this type of liposuction procedure. SUMMARY: The purpose of this liposuction article is to provide a broad overview of the procedure, currently one of the most common operations performed by plastic surgeons. The important medical history that must be obtained, including comorbidities and conditions that increase the risk of deep venous thrombosis, is discussed. Specifics of the physical examination are highlighted. Anesthesia for liposuction is an extremely important factor for the success and safety of the procedure. The anesthetic agents and the wetting solutions used in liposuction are explained to promote safety and good results. A surgical treatment plan for a successful outcome, including the types of lipoplasty, is presented. Outcomes of the procedures, including potential complications, are covered. The rare complication of intestinal or organ perforation from the cannula is discussed to increase the surgeon's level of awareness of the problem and its avoidance. Deep venous thrombosis, associated with pulmonary embolism and death, is the most frequent serious complication of liposuction. This and other sequelae of liposuction are discussed so that the surgeon can evaluate his or her surgical outcomes to improve the results and promote patient safety. FAU - Iverson, Ronald E AU - Iverson RE AD - Stanford, Calif. From the Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University Medical Center. FAU - Pao, Victoria S AU - Pao VS LA - eng PT - Journal Article PT - Review PL - United States TA - Plast Reconstr Surg JT - Plastic and reconstructive surgery JID - 1306050 SB - IM CIN - Plast Reconstr Surg. 2011 Apr;127(4):1735-1738. doi: 10.1097/PRS.0b013e31820a657e. PMID: 21460684 MH - Fluid Therapy MH - Humans MH - *Lipectomy/adverse effects/methods MH - Patient Satisfaction MH - Postoperative Complications/epidemiology MH - Reoperation MH - Seroma/epidemiology MH - Time Factors MH - Treatment Outcome MH - Venous Thrombosis/epidemiology RF - 19 EDAT- 2008/04/11 09:00 MHDA- 2008/05/07 09:00 CRDT- 2008/04/11 09:00 PHST- 2008/04/11 09:00 [pubmed] PHST- 2008/05/07 09:00 [medline] PHST- 2008/04/11 09:00 [entrez] AID - 00006534-200804001-00010 [pii] AID - 10.1097/01.prs.0000308480.33644.56 [doi] PST - ppublish SO - Plast Reconstr Surg. 2008 Apr;121(4 Suppl):1-11. doi: 10.1097/01.prs.0000308480.33644.56. PMID- 24606884 OWN - NLM STAT- MEDLINE DCOM- 20140905 LR - 20211021 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 12 DP - 2014 Mar 7 TI - Phase I clinical trial of multiple-peptide vaccination for patients with advanced biliary tract cancer. PG - 61 LID - 10.1186/1479-5876-12-61 [doi] AB - BACKGROUND: The prognosis of patients with advanced biliary tract cancer (BTC) is extremely poor and only a few standard treatments are available for this condition. We performed a phase I trial to investigate the safety, immune response and anti-tumor effect of vaccination with three peptides derived from cancer-testis antigens. METHODS: This study was conducted as a phase I trial. Nine patients with advanced BTC who had unresectable tumors and were refractory to standard chemotherapy were enrolled. Three HLA-A*2402 restricted epitope peptides-cell division cycle associated 1 (CDCA1), cadherin 3 (CDH3) and kinesin family member 20A (KIF20A)-were administered subcutaneously, and the adverse events and immune response were assessed. The clinical effects observed were the tumor response, progression-free survival (PFS) and overall survival (OS). RESULTS: The three-peptide vaccination was well-tolerated up to a dose of 3 mg per peptide (9 mg total). No grade 3 or 4 adverse events were observed after vaccination. Peptide-specific T cell immune responses were observed in all patients and stable disease was observed in 5 of 9 patients. The median PFS and OS were 3.4 and 9.7 months. The Grade 2 injection site reaction and continuous vaccination after PD judgment appeared to be prognostic of OS. CONCLUSIONS: Multiple-peptide vaccination was well tolerated and induced peptide-specific T-cell responses. TRIAL REGISTRATION: This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR000003229). FAU - Aruga, Atsushi AU - Aruga A AD - Department of Gastroenterological Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. aruga.atsushi@twmu.ac.jp. FAU - Takeshita, Nobuhiro AU - Takeshita N FAU - Kotera, Yoshihito AU - Kotera Y FAU - Okuyama, Ryuji AU - Okuyama R FAU - Matsushita, Norimasa AU - Matsushita N FAU - Ohta, Takehiro AU - Ohta T FAU - Takeda, Kazuyoshi AU - Takeda K FAU - Yamamoto, Masakazu AU - Yamamoto M LA - eng PT - Clinical Trial, Phase I PT - Journal Article DEP - 20140307 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 RN - 0 (Cancer Vaccines) RN - 0 (Epitopes) RN - 0 (Neoplasm Proteins) RN - 0 (Vaccines, Subunit) SB - IM MH - Adult MH - Aged MH - Biliary Tract Neoplasms/drug therapy/*immunology/*pathology MH - Cancer Vaccines/adverse effects/*immunology MH - Disease-Free Survival MH - Epitopes/immunology MH - Female MH - Humans MH - Immunity/immunology MH - Kinetics MH - Male MH - Middle Aged MH - Monitoring, Immunologic MH - Neoplasm Proteins/immunology MH - Neoplasm Staging MH - T-Lymphocytes, Cytotoxic/immunology MH - Treatment Outcome MH - *Vaccination MH - Vaccines, Subunit/adverse effects/*immunology PMC - PMC4015445 EDAT- 2014/03/13 06:00 MHDA- 2014/09/06 06:00 PMCR- 2014/03/07 CRDT- 2014/03/11 06:00 PHST- 2013/09/26 00:00 [received] PHST- 2014/03/04 00:00 [accepted] PHST- 2014/03/11 06:00 [entrez] PHST- 2014/03/13 06:00 [pubmed] PHST- 2014/09/06 06:00 [medline] PHST- 2014/03/07 00:00 [pmc-release] AID - 1479-5876-12-61 [pii] AID - 10.1186/1479-5876-12-61 [doi] PST - epublish SO - J Transl Med. 2014 Mar 7;12:61. doi: 10.1186/1479-5876-12-61. PMID- 32364977 OWN - NLM STAT- MEDLINE DCOM- 20210203 LR - 20210203 IS - 0306-4565 (Print) IS - 0306-4565 (Linking) VI - 89 DP - 2020 Apr TI - Real-time quantification of human physiological state in high temperature environments based on variable weight theory. PG - 102531 LID - S0306-4565(19)30652-7 [pii] LID - 10.1016/j.jtherbio.2020.102531 [doi] AB - Accurate real-time evaluation of human physiological state is significant for safety guidance and early warning for people in high temperature environments. The constant weight method often makes the evaluation results deviating from reality. In this paper, the variable weight theory is adopted to solve above problem. Firstly, a human physiological state evaluation system is proposed. Secondly, the constant weight and variable weight methods are used to obtain the weights of the indexes. Thus, the comprehensive evaluation score is obtained to quantify the human physiological state. Finally, a case study is conducted to demonstrate and verify the proposed evaluation system. It indicates that, the variable weight of rectal temperature, skin temperature, systolic pressure and heart rate is 0.2∼0.77, 0.11∼0.61, 0.03∼0.31, 0.03∼0.31, respectively. And the weights of the skin temperature and the rectal temperature account for a relatively large proportion, ranging from 50% to 92%. The physiological parameters with small constant weight may account for a larger percentage in the evaluation when the physiological parameters reach an extremely harmful condition. This paper can provide more reasonable and scientific method in physiological state quantification for people in high temperature environments. CI - Copyright © 2020 Elsevier Ltd. All rights reserved. FAU - Zheng, Guozhong AU - Zheng G AD - School of Energy, Power and Mechanical Engineering, North China Electric Power University, Baoding, 071003, China. Electronic address: ansystem@126.com. FAU - Wang, Yajing AU - Wang Y AD - School of Energy, Power and Mechanical Engineering, North China Electric Power University, Baoding, 071003, China. FAU - Li, Cong AU - Li C AD - School of Energy, Power and Mechanical Engineering, North China Electric Power University, Baoding, 071003, China. FAU - Wang, Xiao AU - Wang X AD - School of Energy, Power and Mechanical Engineering, North China Electric Power University, Baoding, 071003, China. LA - eng PT - Journal Article DEP - 20200221 PL - England TA - J Therm Biol JT - Journal of thermal biology JID - 7600115 SB - IM MH - *Algorithms MH - Blood Pressure MH - *Body Temperature MH - Heart Rate MH - Hemodynamic Monitoring/*methods MH - Humans MH - Occupational Health/*standards MH - Thermography/*methods MH - *Thermotolerance OTO - NOTNLM OT - AHP OT - Constant weight OT - High temperature OT - Physiological state OT - Real-time evaluation OT - Variable weight EDAT- 2020/05/05 06:00 MHDA- 2021/02/04 06:00 CRDT- 2020/05/05 06:00 PHST- 2019/11/21 00:00 [received] PHST- 2020/01/18 00:00 [revised] PHST- 2020/02/07 00:00 [accepted] PHST- 2020/05/05 06:00 [entrez] PHST- 2020/05/05 06:00 [pubmed] PHST- 2021/02/04 06:00 [medline] AID - S0306-4565(19)30652-7 [pii] AID - 10.1016/j.jtherbio.2020.102531 [doi] PST - ppublish SO - J Therm Biol. 2020 Apr;89:102531. doi: 10.1016/j.jtherbio.2020.102531. Epub 2020 Feb 21. PMID- 19653155 OWN - NLM STAT- MEDLINE DCOM- 20091007 LR - 20250103 IS - 0040-5930 (Print) IS - 0040-5930 (Linking) VI - 66 IP - 8 DP - 2009 Aug TI - [Compulsory hospital admission - coercive measures in medical care]. PG - 595-9 LID - 10.1024/0040-5930.66.8.595 [doi] AB - Any coercive medical intervention is a massive curtailment of the affected person's freedom that is in direct contradiction to their right to self-determination. This is why any such intervention must be laid on a solid legal and ethical foundation. Any decision to commit a person against their will for medical care will have to be made with due regard for both the institution's medical duty and society's interest in public safety. Any such decision must also involve careful consideration of whether the individual concerned is at acute risk of harming or injuring themselves or others as a result of their mental condition. Involuntary committal may be perceived as extremely insulting by the person concerned, who may feel that their right of self-determination has been violated; and at least for a limited period it will inevitably make them feel that they are not being treated like or regarded as an adult. Hence, the following ethical questions arise: Is it justified to suspend an individual's right of self-determination - if only in terms of their place of residence - by committing them for medical treatment and care? And how can such coercive committal be reconciled with the ethical medical principles of autonomy, beneficence, justice and non-maleficence? There are no stock answers or checklist answers to these questions. Whether a committal is warranted must ultimately be decided on a case-by-case basis by thoroughly assessing, weighting and comparing the various principles and considerations involved. FAU - Meier-Allmendinger, Diana AU - Meier-Allmendinger D AD - Ambulatorium Klinik Schützen, Aarau. diana.meier@klinikschuetzen.ch LA - ger PT - English Abstract PT - Journal Article PT - Review TT - Die ärztliche Einweisung - eine Zwangsmassnahme in der Medizin. PL - Switzerland TA - Ther Umsch JT - Therapeutische Umschau. Revue therapeutique JID - 0407224 SB - IM MH - Adult MH - Coercion MH - *Commitment of Persons with Psychiatric Disorders MH - Delivery of Health Care/*ethics MH - Germany MH - Humans MH - Institutionalization/*ethics MH - Patient Advocacy/*ethics MH - Patient Rights/*ethics MH - Physician-Patient Relations/*ethics MH - Practice Patterns, Physicians'/*ethics RF - 10 EDAT- 2009/08/05 09:00 MHDA- 2009/10/08 06:00 CRDT- 2009/08/05 09:00 PHST- 2009/08/05 09:00 [entrez] PHST- 2009/08/05 09:00 [pubmed] PHST- 2009/10/08 06:00 [medline] AID - 10.1024/0040-5930.66.8.595 [doi] PST - ppublish SO - Ther Umsch. 2009 Aug;66(8):595-9. doi: 10.1024/0040-5930.66.8.595. PMID- 35123969 OWN - NLM STAT- MEDLINE DCOM- 20220401 LR - 20220611 IS - 1096-0953 (Electronic) IS - 0013-9351 (Print) IS - 0013-9351 (Linking) VI - 209 DP - 2022 Jun TI - City-level greenness exposure is associated with COVID-19 incidence in China. PG - 112871 LID - S0013-9351(22)00198-0 [pii] LID - 10.1016/j.envres.2022.112871 [doi] LID - 112871 AB - Accumulating studies have suggested an important role of environmental factors (e.g. air pollutants) on the occurrence and development of coronavirus disease 2019 (COVID-19). Evidence concerning the relationship of greenness on COVID-19 is still limited. This study aimed to assess the association between greenness and COVID-19 incidence in 266 Chinese cities. A total of 12,377 confirmed COVID-19 cases were identified through February 29th, 2020. We used the average normalized difference vegetation index (NDVI) during January and February 2020 from MOD13A2 product, to represent the city-level greenness exposure. A generalized linear mixed-effects model was used to estimate the association between NDVI exposure and COVID-19 incidence using COVID-19 cases as the outcome. We evaluated whether the association was modified by population density, GDP per capita, and urbanization rate, and was mediated by air pollutants. We also performed a series of sensitivity analyses to discuss the robustness of our results. Per 0.1 unit increment in NDVI was negatively associated with COVID-19 incidence (IRR: 0.921, 95% CI: 0.898, 0.944) after adjustment for confounders. Associations with COVID-19 incidence were stronger in cities with lower population density, lower GDP per capita, and lower urbanization rate. We failed to detect any mediation effect of air pollutants on the association between NDVI and COVID-19 incidence. Sensitivity analyses also indicated consistent estimates. In conclusion, our study suggested a beneficial association between city-level greenness and COVID-19 incidence. We could not establish which mechanisms may explain this relationship. CI - Copyright © 2022. Published by Elsevier Inc. FAU - Peng, Wenjia AU - Peng W AD - School of Public Health, Fudan University, Shanghai, China; Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, Shanghai, China. FAU - Dong, Yilin AU - Dong Y AD - School of Public Health, Bengbu Medical College, Bengbu, Anhui, China. FAU - Tian, Meihui AU - Tian M AD - School of Public Health, Bengbu Medical College, Bengbu, Anhui, China. FAU - Yuan, Jiacan AU - Yuan J AD - IRDR-ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Kan, Haidong AU - Kan H AD - School of Public Health, Fudan University, Shanghai, China; Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, Shanghai, China; IRDR-ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. FAU - Jia, Xianjie AU - Jia X AD - School of Public Health, Bengbu Medical College, Bengbu, Anhui, China. FAU - Wang, Weibing AU - Wang W AD - School of Public Health, Fudan University, Shanghai, China; Key Laboratory of Public Health Safety (Ministry of Education), Fudan University, Shanghai, China; IRDR-ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China. Electronic address: wwb@fudan.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220203 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 SB - IM MH - *Air Pollution/analysis MH - *COVID-19/epidemiology MH - China/epidemiology MH - Cities/epidemiology MH - Humans MH - Incidence PMC - PMC8812109 OTO - NOTNLM OT - COVID-19 OT - China OT - Greenness OT - Incidence OT - NDVI COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/02/07 06:00 MHDA- 2022/04/02 06:00 PMCR- 2022/06/01 CRDT- 2022/02/06 20:30 PHST- 2021/10/21 00:00 [received] PHST- 2022/01/09 00:00 [revised] PHST- 2022/01/28 00:00 [accepted] PHST- 2022/02/07 06:00 [pubmed] PHST- 2022/04/02 06:00 [medline] PHST- 2022/02/06 20:30 [entrez] PHST- 2022/06/01 00:00 [pmc-release] AID - S0013-9351(22)00198-0 [pii] AID - 112871 [pii] AID - 10.1016/j.envres.2022.112871 [doi] PST - ppublish SO - Environ Res. 2022 Jun;209:112871. doi: 10.1016/j.envres.2022.112871. Epub 2022 Feb 3. PMID- 36045777 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220907 IS - 2049-0801 (Print) IS - 2049-0801 (Electronic) IS - 2049-0801 (Linking) VI - 80 DP - 2022 Aug TI - Influenza vaccination and dementia risk; an unanticipated benefit? PG - 104187 LID - 10.1016/j.amsu.2022.104187 [doi] LID - 104187 AB - Alzheimer's disease (AD) characterized by cognitive decline and dementia has evolved into source of extreme concern globally, often associated with functional dependence and financial instability before progressing to complete degeneration of neural and motor skills. Despite multiple interventions being available, only few have been able to show clinical efficacy, others not meeting satisfactory efficacy endpoints as more options are being explored. According to various studies, influenza vaccines have shown clinical evidence in being effective against reduction in dementia risk. Multiple large-scale cohort studies are being conducted to test the effectiveness of vaccinations against dementia. Some of them have shown significant results, establishing a statistically significant relationship between vaccinations and a reduction in symptomatology in already diagnosed dementia patients. These vaccines offer lower-cost, low-risk mechanism of prevention of dementia with better outcomes than pre-existing vaccines. However, there is a need of more large-scale retrospective studies and randomized trials, with longer follow-ups, to be conducted to assess the safety and consistent efficacy of this strategy. CI - © 2022 The Author(s). FAU - Ali, Eman AU - Ali E AD - Dow University of Health Sciences, Karachi, Pakistan. FAU - Shaikh, Asim AU - Shaikh A AD - Dow University of Health Sciences, Karachi, Pakistan. LA - eng PT - Journal Article DEP - 20220719 PL - England TA - Ann Med Surg (Lond) JT - Annals of medicine and surgery (2012) JID - 101616869 PMC - PMC9422174 OTO - NOTNLM OT - Alzheimer's disease OT - Cohort-studies OT - Dementia OT - Influenza vaccine/therapeutic use COIS- The authors declare that there is no conflict of interest. EDAT- 2022/09/02 06:00 MHDA- 2022/09/02 06:01 PMCR- 2022/07/19 CRDT- 2022/09/01 02:16 PHST- 2022/07/05 00:00 [received] PHST- 2022/07/10 00:00 [accepted] PHST- 2022/09/01 02:16 [entrez] PHST- 2022/09/02 06:00 [pubmed] PHST- 2022/09/02 06:01 [medline] PHST- 2022/07/19 00:00 [pmc-release] AID - S2049-0801(22)00947-5 [pii] AID - 104187 [pii] AID - 10.1016/j.amsu.2022.104187 [doi] PST - epublish SO - Ann Med Surg (Lond). 2022 Jul 19;80:104187. doi: 10.1016/j.amsu.2022.104187. eCollection 2022 Aug. PMID- 29572618 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1092-8472 (Print) IS - 1092-8472 (Linking) VI - 16 IP - 2 DP - 2018 Jun TI - The Use of Statins in Patients With Chronic Liver Disease and Cirrhosis. PG - 226-240 LID - 10.1007/s11938-018-0180-4 [doi] AB - PURPOSE OF REVIEW: Statins are drugs developed to treat hypercholesterolemia. Its use in patients with liver disease has been limited because one of its potential and most feared side effects is hepatotoxicity. However, there is robust evidence that supports the safety of statins in this population in the absence of severe liver dysfunction. In this review, we will summarize the efficacy and safety of statins in cirrhosis. RECENT FINDINGS: Statins are effective in the treatment of dyslipidemia in patients with liver disease, because of their pleiotropic properties. These properties are independent of their effect on cholesterol levels, such as improving endothelial dysfunction or having antioxidant, antifibrotic, anti-inflammatory, antiproliferative, antiangiogenic, proapoptotic, or immunomodulation properties. Statins have been studied in other areas such as in treatment of portal hypertension, prevention of hepatocellular carcinoma, and/or protection against ischemia/reperfusion injury. Approved indications for statins in patients with cirrhosis are those of the general population, including dyslipidemia and increased cardiovascular risk. Compensated cirrhosis is not a contraindication. In patients with decompensated cirrhosis, statins should be prescribed with extreme caution at low doses, and with frequent monitoring of creatinine phosphokinase levels in order to detect adverse events in a timely fashion. FAU - Moctezuma-Velázquez, Carlos AU - Moctezuma-Velázquez C AD - Division of Gastroenterology and Liver Unit, University of Alberta, 8540 112 Street NW, Zeidler Ledcor Centre, Room 1-20B, Edmonton, Alberta, T6G 2X8, Canada. FAU - Abraldes, Juan G AU - Abraldes JG AD - Division of Gastroenterology and Liver Unit, University of Alberta, 8540 112 Street NW, Zeidler Ledcor Centre, Room 1-20B, Edmonton, Alberta, T6G 2X8, Canada. FAU - Montano-Loza, Aldo J AU - Montano-Loza AJ AD - Division of Gastroenterology and Liver Unit, University of Alberta, 8540 112 Street NW, Zeidler Ledcor Centre, Room 1-20B, Edmonton, Alberta, T6G 2X8, Canada. aldo.montano-loza@ualberta.ca. LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Treat Options Gastroenterol JT - Current treatment options in gastroenterology JID - 9815941 OTO - NOTNLM OT - Chemical- and drug-induced liver injury OT - Dyslipidemias OT - End-stage liver disease OT - Hydroxymethylglutaryl-CoA reductase inhibitors OT - Hypertension, portal OT - Liver cirrhosis EDAT- 2018/03/25 06:00 MHDA- 2018/03/25 06:01 CRDT- 2018/03/25 06:00 PHST- 2018/03/25 06:00 [pubmed] PHST- 2018/03/25 06:01 [medline] PHST- 2018/03/25 06:00 [entrez] AID - 10.1007/s11938-018-0180-4 [pii] AID - 10.1007/s11938-018-0180-4 [doi] PST - ppublish SO - Curr Treat Options Gastroenterol. 2018 Jun;16(2):226-240. doi: 10.1007/s11938-018-0180-4. PMID- 23617187 OWN - NLM STAT- MEDLINE DCOM- 20130718 LR - 20130426 IS - 0301-4894 (Print) IS - 0301-4894 (Linking) VI - 114 IP - 2 DP - 2013 Mar TI - [History of discussions of the Committee for Medical Safety Review]. PG - 80-4 AB - After notorious medical accidents in 1999 and 2000, medical safety promotion was enhanced in Japan. After struggling for years, the Ministry of Health, Labour and Welfare succeeded in increasing societal interest, including that of the medical community, in medical accident review, and a draft outline of the Bill for the Committee for Medical Safety Review was announced in 2008. This draft outline proposed establishing an independent governmental body to conduct medical accident reviews. The body was meant to collect information on all cases of death related to medical care, review the cases if needed, and announce the findings to prevent future accidents. It was also planned to adjust criminal procedures in such cases, about which the medical community was extremely concerned. Anxiety over that section of the draft outline was expressed by medical personnel, and it was decided to reconsider the plan. In August 2011, a study group on no-fault compensation and related matters was established. Its four meetings led to the establishment of a working group for discussions on the optimum method for accident review. In February 2012, a working group on the accident review system and related matters was established. After eight meetings, the opinions of its members still differed considerably. The search for a definitive conclusion on medical accident review that will find widespread acceptance continues. FAU - Miyamoto, Tetsuya AU - Miyamoto T AD - Office of Medical Safety Promotion, Health Policy Bureau, Ministry of Health, Labour and Welfare, Japan. LA - jpn PT - English Abstract PT - Journal Article PL - Japan TA - Nihon Geka Gakkai Zasshi JT - Nihon Geka Gakkai zasshi JID - 0405405 SB - IM MH - *Government Agencies/legislation & jurisprudence MH - Humans MH - Iatrogenic Disease/prevention & control MH - Japan MH - *Medical Errors EDAT- 2013/04/27 06:00 MHDA- 2013/07/19 06:00 CRDT- 2013/04/27 06:00 PHST- 2013/04/27 06:00 [entrez] PHST- 2013/04/27 06:00 [pubmed] PHST- 2013/07/19 06:00 [medline] PST - ppublish SO - Nihon Geka Gakkai Zasshi. 2013 Mar;114(2):80-4. PMID- 38361712 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240217 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 16 IP - 1 DP - 2024 Jan TI - A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis. PG - e52340 LID - 10.7759/cureus.52340 [doi] LID - e52340 AB - Oral mucositis (OM) is one of the common side effects of radiotherapy and chemotherapy. It is an extremely painful condition characterized by erythema, edema, and ulceration of the oral mucosa. Many plant-based and chemical formulations are used to prevent OM. The aim of the study is to evaluate the efficacy and safety of different black mulberry formulations in chemotherapy and/or radiotherapy-induced OM. A systematic search was performed using PubMed, Excerpta Medica database (Embase), the Cochrane Library, and Web of Science databases for articles published until March 2023. We have included studies conducted on people undergoing chemotherapy and/or radiotherapy and compared the effect of any mulberry formulation with other interventions. Out of 30 articles retrieved, four articles with a cumulative sample size of (N = 297) were included in the review. Mulberry formulations were compared with no intervention, grape molasses, chlorhexidine, and sodium bicarbonate. Out of the four articles, in three articles, mulberry formulations showed a significant decrease in grade 2 and grade 3 OM and also showed better prevention of OM as compared to the other intervention and control groups, and in one article, the grape molasses was more preventive for the occurrence of OM. Mulberry showed a significant decrease in dry mouth. Mulberry showed more improvement in the pain score and quality of life. The incidence and severity were lower in the mulberry group than in other interventions. One article showed less weight loss, and another article showed gradual weight gain from the use of mulberries. From this, we conclude that mulberry is effective for the treatment of OM. Mulberry also shows improvement in the pain score and quality of life. CI - Copyright © 2024, Raghunand Sindhe et al. FAU - Raghunand Sindhe, J AU - Raghunand Sindhe J AD - Dentistry, Health Care Global Hospitals, Bangalore, IND. FAU - Asha, V AU - Asha V AD - Oral Medicine and Radiology, The Oxford Dental College and Hospital, Bangalore, IND. FAU - Arvind, Muthukrishnan AU - Arvind M AD - Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Chennai, IND. FAU - Shabana, Shaik AU - Shabana S AD - Oral Medicine and Radiology, Al Ameen Dental College, Bijapur, IND. FAU - Sowbhagya Lakshmi, A AU - Sowbhagya Lakshmi A AD - Oral Medicine and Radiology, The Oxford Dental College and Hospital, Bangalore, IND. FAU - Tanvi, Khandekar AU - Tanvi K AD - Evidence Synthesis, coGuide Academy, Bangalore, IND. FAU - Ananta, Gimre AU - Ananta G AD - Evidence Synthesis, coGuide Academy, Bangalore, IND. LA - eng PT - Journal Article PT - Review DEP - 20240115 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC10867387 OTO - NOTNLM OT - chemotherapy OT - mulberry formulations OT - oral mucositis OT - quality of life OT - radiotherapy COIS- The authors have declared that no competing interests exist. EDAT- 2024/02/16 06:43 MHDA- 2024/02/16 06:44 PMCR- 2024/01/15 CRDT- 2024/02/16 03:46 PHST- 2024/01/12 00:00 [accepted] PHST- 2024/02/16 06:44 [medline] PHST- 2024/02/16 06:43 [pubmed] PHST- 2024/02/16 03:46 [entrez] PHST- 2024/01/15 00:00 [pmc-release] AID - 10.7759/cureus.52340 [doi] PST - epublish SO - Cureus. 2024 Jan 15;16(1):e52340. doi: 10.7759/cureus.52340. eCollection 2024 Jan. PMID- 35729301 OWN - NLM STAT- MEDLINE DCOM- 20221118 LR - 20221118 IS - 1874-9356 (Electronic) IS - 0015-5632 (Linking) VI - 67 IP - 6 DP - 2022 Dec TI - Mining the diversity and functional profile of bacterial symbionts from the larvae of Chironomus circumdatus (bloodworms). PG - 861-872 LID - 10.1007/s12223-022-00984-3 [doi] AB - Chironomids are the most abundant aquatic insects in freshwater habitats that can survive in extreme conditions. In this study, as the microbiome provides extended genotype to the host to perform various functions, we explored the microbiota of the Chironomus circumdatus larvae to find out the putative role played by the symbiotic bacteria for the host. The metabarcoding analyses of the larvae revealed that the insect harbors 1771 phylotypes. Out of the various microbial communities found, the majority corresponded to the phyla Proteobacteria (52.59%) and Actinobacteria (20.56%), respectively. The midges also harbored Klebsiella (2.57%), Enterobacter (1.32%), Bacillus (2.29%), and Acinetobacter (2.13%) genera that are involved in detoxification of xenobiotics present in the water. The presence of radiation-resistant genera like Deinococcus, including bacterial species like radiodurans, a highly radiation-resistant bacterium, indicates its potential to support the host's ability to sustain in adverse environments. The functional profiling of the bacteria showed the relative abundance of many enzyme groups, such as transferases (40.62%), oxidoreductases (23.49%), and hydrolases (3.77%). The results indicate that the larvae harbor a considerable variety of bacteria that help the host adapt and survive in the polluted waters. The present study provides thorough insights into the microbiome of the C. circumdatus larvae that can be exploited for the bioremediation of certain pollutants through biomimetic strategies. It also gives us a wake-up call to take a good look at the guts of these disease-carrying insects' inabilities to spread deadly human diseases. CI - © 2022. Institute of Microbiology, Academy of Sciences of the Czech Republic, v.v.i. FAU - Shaha, Chaitali M AU - Shaha CM AD - Department of Zoology, Savitribai Phule Pune University, Ganeshkhind, Pune, 411007, India. FAU - Dar, Mudasir A AU - Dar MA AD - School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. FAU - Pandit, Radhakrishna S AU - Pandit RS AUID- ORCID: 0000-0003-0918-8284 AD - Department of Zoology, Savitribai Phule Pune University, Ganeshkhind, Pune, 411007, India. rspandit@unipune.ac.in. LA - eng PT - Journal Article DEP - 20220621 PL - United States TA - Folia Microbiol (Praha) JT - Folia microbiologica JID - 0376757 SB - IM MH - Animals MH - Humans MH - *Chironomidae/microbiology MH - Larva/microbiology MH - Bacteria/genetics MH - *Microbiota MH - *Gastrointestinal Microbiome OTO - NOTNLM OT - Bacterial enzymes OT - Bioremediation OT - Microbiota OT - Non-biting midges OT - Pathogens EDAT- 2022/06/22 06:00 MHDA- 2022/11/19 06:00 CRDT- 2022/06/21 23:26 PHST- 2022/01/27 00:00 [received] PHST- 2022/06/10 00:00 [accepted] PHST- 2022/06/22 06:00 [pubmed] PHST- 2022/11/19 06:00 [medline] PHST- 2022/06/21 23:26 [entrez] AID - 10.1007/s12223-022-00984-3 [pii] AID - 10.1007/s12223-022-00984-3 [doi] PST - ppublish SO - Folia Microbiol (Praha). 2022 Dec;67(6):861-872. doi: 10.1007/s12223-022-00984-3. Epub 2022 Jun 21. PMID- 32307246 OWN - NLM STAT- MEDLINE DCOM- 20211216 LR - 20221207 IS - 1995-9133 (Electronic) IS - 1684-1182 (Linking) VI - 54 IP - 4 DP - 2021 Aug TI - Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for clinicians. PG - 575-580 LID - S1684-1182(20)30089-X [pii] LID - 10.1016/j.jmii.2020.03.029 [doi] AB - BACKGROUND: Necrotizing enterocolitis (NEC) is one of the most serious complications in preterm infants. Probiotics have been used to prevent NEC. Safety is a major concern for this practice. METHODS: We reported a female preterm infant who received oral Lactobacillus rhamnosus GG but developed sepsis 12 days after the treatment. Cultures of blood and the catheter tip yielded L. rhamnosus. Next-generation sequencing was performed to analyze isolates from blood, stool, catheter, and product capsules. We also determined the capacities of these isolates to form biofilms. A literature review was performed. RESULTS: The patient was treated with ampicillin and piperacillin/tazobactam, and she subsequently recovered without complications. The analysis of genome sequences indicated that all the isolates belonged to the clone of L. rhamnosus GG (ATCC 53103), suggesting that sepsis was a catheter-related infection caused by the oral probiotic. L. rhamnosus GG (ATCC 53103) and the probiotic strain tested formed biofilms under all growth conditions. Isolates from the blood and catheter tip also formed biofilms, but the stool isolate did not. The capacity of intrinsic biofilm formation in L. rhamnosus GG depended on environmental factors and the type of culture medium. Literature review of L. rhamnosus GG sepsis in preterm and young infants found that nearly 60% of the patients had a suspected or confirmed infected catheter. CONCLUSION: The study showed that the capacity of L. rhamnosus GG to form biofilms, especially in the presence of glucose, is a critical factor leading to the probiotic-related sepsis in preterm infants. CI - Copyright © 2020. Published by Elsevier B.V. FAU - Chiang, Ming-Chou AU - Chiang MC AD - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Chen, Chyi-Liang AU - Chen CL AD - Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Feng, Ye AU - Feng Y AD - Sir Run Run Shaw Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China. FAU - Chen, Chien-Chang AU - Chen CC AD - Division of Pediatric Gastroenterology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Lien, Reyin AU - Lien R AD - Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. FAU - Chiu, Cheng-Hsun AU - Chiu CH AD - Molecular Infectious Disease Research Center, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address: chchiu@adm.cgmh.org.tw. LA - eng PT - Case Reports PT - Journal Article PT - Review DEP - 20200403 PL - England TA - J Microbiol Immunol Infect JT - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JID - 100956211 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Administration, Oral MH - Anti-Bacterial Agents/therapeutic use MH - Biofilms/growth & development MH - Enterocolitis, Necrotizing/prevention & control MH - Humans MH - Infant, Extremely Premature MH - Infant, Newborn MH - Lacticaseibacillus rhamnosus/drug effects/genetics/isolation & purification/*pathogenicity MH - Probiotics/administration & dosage/*adverse effects MH - Sepsis/diagnosis/drug therapy/*etiology OTO - NOTNLM OT - Bacteremia OT - Biofim OT - Catheter-associated bloodstream infection OT - Genome sequence OT - Lactobacillus rhamnosus COIS- Declaration of Competing Interest The authors declare no conflicts of interest. EDAT- 2020/04/21 06:00 MHDA- 2021/12/17 06:00 CRDT- 2020/04/21 06:00 PHST- 2020/02/10 00:00 [received] PHST- 2020/03/24 00:00 [revised] PHST- 2020/03/26 00:00 [accepted] PHST- 2020/04/21 06:00 [pubmed] PHST- 2021/12/17 06:00 [medline] PHST- 2020/04/21 06:00 [entrez] AID - S1684-1182(20)30089-X [pii] AID - 10.1016/j.jmii.2020.03.029 [doi] PST - ppublish SO - J Microbiol Immunol Infect. 2021 Aug;54(4):575-580. doi: 10.1016/j.jmii.2020.03.029. Epub 2020 Apr 3. PMID- 37465332 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230720 IS - 2474-1949 (Electronic) IS - 2474-1949 (Linking) VI - 5 IP - 4 DP - 2020 Oct TI - Cardiac Tamponade. PG - S84-S107 LID - 10.21980/J81D1D [doi] AB - AUDIENCE: This simulation is designed to educate emergency medicine residents and medical students on the recognition and management of cardiac tamponade, as well as encourage providers to become familiar with their states' disclosure laws for sentinel events. INTRODUCTION: Cardiac tamponade is an emergent condition in which the accumulation of pericardial fluid and the consequent increase in hydrostatic pressure becomes severe enough to compromise the normal diastolic and systolic function of the heart, resulting in hemodynamic instability.1 The causes of cardiac tamponade are numerous because it is a potential complication of any of a number of pericardial disease processes, including infectious, inflammatory, traumatic, and malignant etiologies.1,2 Clinical presentations may vary and symptoms can be non-specific, which can lead to delayed or missed diagnoses and poor patient outcomes.3 In addition to this, the incidence of this condition is rising due to the increasing frequency of cardiac procedures performed (ie, pacemaker placement).4 Therefore, it is important for medical providers to have a high index of suspicion for the diagnosis based on patient presentation and to quickly provide necessary treatment to stabilize the patient. EDUCATIONAL OBJECTIVES: By the end of this simulation session, the learner will be able to: (1) describe a diagnostic differential for dizziness (2) describe the pathophysiology of cardiac tamponade (3) describe the acute management of cardiac tamponade, including fluid bolus and pericardiocentesis (4) describe the electrocardiogram (ECG) findings of pericardial effusion (5) describe the ultrasound findings of cardiac tamponade (6) describe the indications for emergent bedside pericardiocentesis versus medical stabilization and delayed pericardiocentesis for cardiac tamponade (7) describe the procedural steps for pericardiocentesis, and (8) describe your state's laws regarding disclosure for sentinel events. EDUCATIONAL METHODS: This session is conducted using high-fidelity simulation, followed by a debriefing session on evaluation and treatment of cardiac tamponade. However, it may also be run as an oral board case. EDUCATIONAL METHODS: Our residents were provided an electronic survey at the completion of the debriefing session so they may rate different aspects of the simulation, as well as provide qualitative feedback on the scenario. This survey is specific to the local institution's simulation center. RESULTS: Feedback was largely positive because many learners mentioned during debriefing that they are not comfortable with pericardiocentesis and have limited opportunities to practice the procedure. None of our residents were familiar with our state's or institution's disclosure laws for sentinel events.The local institution's simulation center feedback form is based on the Center of Medical Simulation's Debriefing Assessment for Simulation in Healthcare (DASH) Student Version Short Form with the inclusion of required qualitative feedback if an element was scored less than a 6 or 7.5 This session received a majority of 6 (consistently effective/very good) and 7 scores (extremely effective/outstanding). DISCUSSION: This is a potential method for educating future medical providers on the diagnosis and management of cardiac tamponade in an emergency department setting. Learners initially had a wide range of differentials for the chief complaint of dizziness. We used an ECG with low voltage but without electrical alternans. When asked to provide an ECG interpretation, low voltage was intermittently explicitly interpreted by learners. We were concerned that if we showed an ECG with electrical alternans, learners may quickly arrive at the diagnosis without focusing on the subtleties of a physical exam, including looking for jugular venous distention (JVD) or pulsus paradoxus.We did not have the patient decompensate if their international normalized ratio (INR) was not immediately reversed, given likely delay for in vivo coagulation to occur in the face of life-threatening tamponade, but this provided a robust discussion during debriefing if reversal should be emergently initiated.Many residents voiced that they were uncomfortable performing a pericardiocentesis because they only had a few opportunities to do so on human cadavers, and they appreciated the opportunity to review this.Unexpectedly, when the patient asked the learners if he should sue the cardiologist, the majority of groups told the patient that the cardiologist was not liable because tamponade is a known complication of cardiac ablation and likely reviewed this while obtaining informed consent. None of the learners were familiar with Ohio's disclosure laws for sentinel events. This identified a gap in knowledge that may be addressed in future learning sessions.Our main take-away is to continue providing low-frequency, high-acuity cases that provide the opportunity to review infrequent pathologies and procedures, as well as including patient safety and administrative learning points. TOPICS: Medical simulation, cardiac tamponade, pericardial effusion, cardiac emergencies, obstructive shock, sentinel events, iatrogenic injury, medical disclosure. CI - © 2020 Chu, et al. FAU - Chu, Alan AU - Chu A AD - The Ohio State University, Department of Emergency Medicine, Columbus, OH. FAU - Yee, Jennifer AU - Yee J AD - The Ohio State University, Department of Emergency Medicine, Columbus, OH. LA - eng PT - Journal Article DEP - 20201015 PL - United States TA - J Educ Teach Emerg Med JT - Journal of education & teaching in emergency medicine JID - 101741448 PMC - PMC10332517 EDAT- 2020/10/15 00:00 MHDA- 2020/10/15 00:01 PMCR- 2020/10/15 CRDT- 2023/07/19 03:59 PHST- 2020/06/29 00:00 [received] PHST- 2020/09/10 00:00 [accepted] PHST- 2020/10/15 00:01 [medline] PHST- 2020/10/15 00:00 [pubmed] PHST- 2023/07/19 03:59 [entrez] PHST- 2020/10/15 00:00 [pmc-release] AID - jetem-5-4-s84 [pii] AID - 10.21980/J81D1D [doi] PST - epublish SO - J Educ Teach Emerg Med. 2020 Oct 15;5(4):S84-S107. doi: 10.21980/J81D1D. eCollection 2020 Oct. PMID- 26028181 OWN - NLM STAT- MEDLINE DCOM- 20160517 LR - 20150817 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 11 IP - 4 DP - 2015 Aug TI - Self-cathing experience journal: Enhancing the patient and family experience in clean intermittent catheterization. PG - 187.e1-6 LID - S1477-5131(15)00113-8 [pii] LID - 10.1016/j.jpurol.2015.03.011 [doi] AB - OBJECTIVE: This pilot study evaluated the safety, feasibility, and usefulness of the Self-Cathing Experience Journal (SC-EJ), an online resource for patients and families to address issues and stigma surrounding clean intermittent catheterization (CIC). Modeled after previous assessments of the Cardiac and Depression Experience Journals (EJs), this project uniquely included patients and caregivers. We explored whether patients and caregivers would find the SC-EJ helpful in increasing their understanding of CIC, accepting the medical benefits of self-catheterization, improving hopefulness, and diminishing social isolation. METHODS: Patients seen in a tertiary urology clinic were asked to view the SC-EJ for 30 min and rate its safety and efficacy. The cross-sectional sample included 25 families: 17 surveys were completed by the patient and their caregiver, five by the patient only, and three by the caregiver only. Mean patient age was 15.7 ± 5.8 years (range 7-29 years). The patients were 64% female, and 72% used CIC due to neurological diagnoses. RESULTS: Mean overall patient satisfaction with the SC-EJ was moderately high (mean = 5, out of a 7-point Likert scale from 1 = not at all to 7 = extremely). Mean overall caregiver satisfaction was high (mean = 5.55) and was similar to caregiver satisfaction scores recorded in caregivers with children with congenital heart disease and depression (mean = 5.7 and mean = 5.75, respectively). No significant differences were noted in satisfaction between CIC patients and CIC caregivers or among caregivers of the three populations surveyed (CIC, Cardiac, and Depression). CIC patients and caregivers reported that SC-EJ viewing gave them a strong sense that others are facing similar issues (patient mean = 6.15, caregiver mean = 6.21) and that it was helpful to read about other families' CIC experiences (patient mean = 6, caregiver mean = 5.89). DISCUSSION: The SC-EJ appears to be safe, feasible, and useful to patients and families using CIC. Ratings from caregivers of CIC patients were similar to other cohorts of caregivers facing chronic childhood conditions. Despite beliefs that the EJ format best targets adults, high satisfaction ratings among patients suggest that the SC-EJ is acceptable and beneficial to children and adolescents. This web-based intervention can be a helpful clinical supplement in promoting healthy coping skills and a decreased sense of isolation among patients and families facing CIC. The unique integration of real patient and family experiences with accurate and vetted medical knowledge has the potential to enhance resiliency among viewers who use CIC. CI - Copyright © 2015 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Holland, Jennifer E AU - Holland JE AD - Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. FAU - DeMaso, David R AU - DeMaso DR AD - Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. Electronic address: david.demaso@childrens.harvard.edu. FAU - Rosoklija, Ilina AU - Rosoklija I AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Johnson, Kathryn L AU - Johnson KL AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Manning, Diane AU - Manning D AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Bellows, Alexandra L AU - Bellows AL AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. FAU - Bauer, Stuart B AU - Bauer SB AD - Department of Urology, Boston Children's Hospital, Boston, MA, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150421 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM CIN - J Urol. 2016 Jun;195(6):1884. doi: 10.1016/j.juro.2016.03.021. PMID: 27191113 MH - *Adaptation, Psychological MH - Adolescent MH - Adult MH - Child MH - Cross-Sectional Studies MH - Feasibility Studies MH - Female MH - Humans MH - Intermittent Urethral Catheterization/methods/*psychology MH - Male MH - Patient Compliance/psychology MH - Patient Education as Topic/*methods MH - *Patient Satisfaction MH - Pilot Projects MH - *Quality of Life MH - *Self Concept MH - Social Adjustment MH - Urinary Bladder, Neurogenic/*psychology/therapy MH - Young Adult OTO - NOTNLM OT - Bladder dysfunction OT - Clean intermittent catheterization OT - Patient education OT - Patient satisfaction OT - Pediatric urology EDAT- 2015/06/02 06:00 MHDA- 2016/05/18 06:00 CRDT- 2015/06/02 06:00 PHST- 2014/12/29 00:00 [received] PHST- 2015/03/17 00:00 [accepted] PHST- 2015/06/02 06:00 [entrez] PHST- 2015/06/02 06:00 [pubmed] PHST- 2016/05/18 06:00 [medline] AID - S1477-5131(15)00113-8 [pii] AID - 10.1016/j.jpurol.2015.03.011 [doi] PST - ppublish SO - J Pediatr Urol. 2015 Aug;11(4):187.e1-6. doi: 10.1016/j.jpurol.2015.03.011. Epub 2015 Apr 21. PMID- 22405876 OWN - NLM STAT- MEDLINE DCOM- 20120802 LR - 20161125 IS - 1873-4138 (Electronic) IS - 0309-1740 (Linking) VI - 91 IP - 3 DP - 2012 Jul TI - A false single nucleotide polymorphism generated by gene duplication compromises meat traceability. PG - 347-51 LID - 10.1016/j.meatsci.2012.02.016 [doi] AB - Controlling meat traceability using SNPs is an effective method of ensuring food safety. We have analyzed several SNPs to create a panel for bovine genetic identification and traceability studies. One of these was the transversion g.329C>T (Genbank accession no. AJ496781) on the cytochrome P450 17A1 gene, which has been included in previously published panels. Using minisequencing reactions, we have tested 701 samples belonging to eight Spanish cattle breeds. Surprisingly, an excess of heterozygotes was detected, implying an extreme departure from Hardy-Weinberg equilibrium (P<0.001). By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value. We recommend that this ambiguous SNP, as well as other polymorphisms located in this region, should not be used in identification, traceability or disease association studies. Annotation of these false SNPs should improve association studies and avoid misinterpretations. CI - Copyright © 2012 Elsevier Ltd. All rights reserved. FAU - Sanz, Arianne AU - Sanz A AD - Laboratorio de Genética Bioquímica (LAGENBIO), Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain. arianne@unizar.es FAU - Ordovás, Laura AU - Ordovás L FAU - Zaragoza, Pilar AU - Zaragoza P FAU - Sanz, Albina AU - Sanz A FAU - de Blas, Ignacio AU - de Blas I FAU - Rodellar, Clementina AU - Rodellar C LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120222 PL - England TA - Meat Sci JT - Meat science JID - 101160862 RN - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase) SB - IM MH - Animals MH - Breeding MH - Cattle/*genetics MH - Food Safety/*methods MH - Food Supply/standards MH - *Gene Duplication MH - Gene Frequency MH - *Genotype MH - Heterozygote MH - Humans MH - *Meat MH - *Polymorphism, Single Nucleotide MH - Sequence Analysis, DNA MH - Spain MH - Steroid 17-alpha-Hydroxylase/*genetics EDAT- 2012/03/13 06:00 MHDA- 2012/08/03 06:00 CRDT- 2012/03/13 06:00 PHST- 2011/04/26 00:00 [received] PHST- 2012/01/17 00:00 [revised] PHST- 2012/02/14 00:00 [accepted] PHST- 2012/03/13 06:00 [entrez] PHST- 2012/03/13 06:00 [pubmed] PHST- 2012/08/03 06:00 [medline] AID - S0309-1740(12)00061-7 [pii] AID - 10.1016/j.meatsci.2012.02.016 [doi] PST - ppublish SO - Meat Sci. 2012 Jul;91(3):347-51. doi: 10.1016/j.meatsci.2012.02.016. Epub 2012 Feb 22. PMID- 22241207 OWN - NLM STAT- MEDLINE DCOM- 20120301 LR - 20190911 IS - 0080-6234 (Print) IS - 0080-6234 (Linking) VI - 45 IP - 6 DP - 2011 Dec TI - [Medical device reprocessing: a regulatory model proposal for Brazilian hospitals]. PG - 1459-65 LID - S0080-62342011000600026 [pii] AB - Medical device reprocessing is extremely important and complex, thus requiring both the operational skills for its implementation and the technical qualification of the professionals involved in the activity. The typical issues of medical device reprocessing involve technical, economical and regulatory aspects when involving either the so-called reusable articles or those considered as for a single use. The objective of the present study is to propose a new regulatory model for medical device reprocessing in Brazil that would, on the one hand, satisfy the requirements for quality and safety, as recommended in the literature and, on the other hand, prove to be operational under the conditions prevailing in Brazilian hospitals. The elaboration of the present normative proposal was based on the Consensus Conference technique among specialists in the area. Guided by the contribution of these specialists, a proposal is put forth of a regulatory model for reprocessing medical products, so as to address some previously identified gaps in the normative body currently used in Brazil. FAU - Costa, Eliana Auxiliadora Magalhães AU - Costa EA AD - Universidade Estadual da Bahia, Salvador, BA, Brasil. costaeliana2003@hotmail.com FAU - Costa, Ediná Alves AU - Costa EA FAU - Graziano, Kazuko Uchikawa AU - Graziano KU FAU - Padoveze, Maria Clara AU - Padoveze MC LA - por PT - English Abstract PT - Journal Article TT - Reprocessamento de produtos médicos: uma proposta de modelo regulatório para hospitais brasileiros. PL - Brazil TA - Rev Esc Enferm USP JT - Revista da Escola de Enfermagem da U S P JID - 0242726 MH - Brazil MH - Consensus MH - Equipment Reuse/*standards MH - *Hospitals MH - Practice Guidelines as Topic EDAT- 2012/01/14 06:00 MHDA- 2012/03/02 06:00 CRDT- 2012/01/14 06:00 PHST- 2010/10/18 00:00 [received] PHST- 2011/03/15 00:00 [accepted] PHST- 2012/01/14 06:00 [entrez] PHST- 2012/01/14 06:00 [pubmed] PHST- 2012/03/02 06:00 [medline] AID - S0080-62342011000600026 [pii] AID - 10.1590/s0080-62342011000600026 [doi] PST - ppublish SO - Rev Esc Enferm USP. 2011 Dec;45(6):1459-65. doi: 10.1590/s0080-62342011000600026. PMID- 2622551 OWN - NLM STAT- MEDLINE DCOM- 19900326 LR - 20061115 IS - 0026-4733 (Print) IS - 0026-4733 (Linking) VI - 44 IP - 20 DP - 1989 Oct 31 TI - [Lymphovenous anastomosis in severe ascites]. PG - 2143-8 AB - The authors dealt with 37 patients suffering from advanced liver cirrhosis with ascites. Eighteen patients out of them underwent Denver peritoneum-jugular shunt as a first choice procedure, the other 19 patients underwent lymphovenous anastomosis. The extremely advanced hepatic damage and the general conditions of these patients discouraged us to perform a portocaval shunt. In the 19 patients who underwent lymphovenous anastomosis we had no mortality rate. Two patients showed post-operative complications: 1 patient complained which hoarseness regressed in 5 months and the other patient suffered from a spleno-mesenteric-portal thrombosis with digestive hemorrhage from gastro-esophageal varices. In 6 patients out of 19 who underwent lymphovenous anastomosis, we did not obtain any immediate positive effects on ascites. In 4 patients, after 3 months, the ascites came back ingravescent and in the other 9 patients the positive effects on ascites were still evident after 1 year. Despite failure to obtain very comforting results, they suggest to employ this technique at any rate, as the first procedure, to make ascites more "manageable", because of its safety. FAU - Bracci, F AU - Bracci F FAU - Farina, F AU - Farina F FAU - Zampino, M A AU - Zampino MA FAU - Bracaglia, C AU - Bracaglia C FAU - Salvini, G AU - Salvini G FAU - Cucchiara, G AU - Cucchiara G LA - ita PT - English Abstract PT - Journal Article TT - L'anastomosi linfovenosa nell'ascite difficile. PL - Italy TA - Minerva Chir JT - Minerva chirurgica JID - 0400726 SB - IM MH - Anastomosis, Surgical MH - Ascites/physiopathology/*surgery MH - Female MH - Humans MH - Jugular Veins/*surgery MH - Male MH - Middle Aged MH - Thoracic Duct/*surgery EDAT- 1989/10/31 00:00 MHDA- 1989/10/31 00:01 CRDT- 1989/10/31 00:00 PHST- 1989/10/31 00:00 [pubmed] PHST- 1989/10/31 00:01 [medline] PHST- 1989/10/31 00:00 [entrez] PST - ppublish SO - Minerva Chir. 1989 Oct 31;44(20):2143-8. PMID- 37533424 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230804 IS - 2296-9144 (Electronic) IS - 2296-9144 (Linking) VI - 10 DP - 2023 TI - Compliant robotic behaviors for satellite servicing. PG - 1124207 LID - 10.3389/frobt.2023.1124207 [doi] LID - 1124207 AB - The demands of traditional industrial robotics differ significantly from those of space robotics. While industry requires robots that can perform repetitive tasks with precision and speed, the space environment needs robots to cope with uncertainties, dynamics, and communication delays or interruptions, similar to human astronauts. These demands make a well-suited application for compliant robotics and behavior-based programming. Pose Target Wrench Limiting (PTWL) is a compliant behavior paradigm developed specifically to meet these demands. PTWL controls a robot by moving a virtual attractor to a target pose. The attractor applies virtual forces, based on stiffness and damping presets, to an underlying admittance controller. Guided by virtual forces, the robot will follow the attractor until safety conditions are violated or success criteria are met. We tested PTWL on a variety of quasi-static tasks that may be useful for future space operations. Our results demonstrate that PTWL is an extremely powerful tool. It makes teleoperation easy and safe for a wide range of quasi-static tasks. It also facilitates the creation of semi-autonomous state machines that can reliably complete complex tasks with minimal human intervention. CI - Copyright © 2023 Cressman, Pokharna and Newman. FAU - Cressman, Joseph AU - Cressman J AD - Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States. FAU - Pokharna, Rahul AU - Pokharna R AD - Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States. FAU - Newman, Wyatt AU - Newman W AD - Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States. LA - eng PT - Journal Article DEP - 20230718 PL - Switzerland TA - Front Robot AI JT - Frontiers in robotics and AI JID - 101749350 PMC - PMC10391545 OTO - NOTNLM OT - admittance control OT - behaviors OT - compliance OT - remote supervision OT - satellite servicing Frontiers OT - teleoperation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/08/03 06:42 MHDA- 2023/08/03 06:43 PMCR- 2023/07/18 CRDT- 2023/08/03 03:44 PHST- 2022/12/14 00:00 [received] PHST- 2023/06/23 00:00 [accepted] PHST- 2023/08/03 06:43 [medline] PHST- 2023/08/03 06:42 [pubmed] PHST- 2023/08/03 03:44 [entrez] PHST- 2023/07/18 00:00 [pmc-release] AID - 1124207 [pii] AID - 10.3389/frobt.2023.1124207 [doi] PST - epublish SO - Front Robot AI. 2023 Jul 18;10:1124207. doi: 10.3389/frobt.2023.1124207. eCollection 2023. PMID- 29853172 OWN - NLM STAT- MEDLINE DCOM- 20181001 LR - 20221207 IS - 1618-0623 (Electronic) IS - 0944-5013 (Linking) VI - 212-213 DP - 2018 Jul-Aug TI - Effectiveness of tailocins produced by Pseudomonas fluorescens SF4c in controlling the bacterial-spot disease in tomatoes caused by Xanthomonas vesicatoria. PG - 94-102 LID - S0944-5013(17)31266-1 [pii] LID - 10.1016/j.micres.2018.05.010 [doi] AB - The development of alternatives for the use of chemical pesticides for plant disease control is the present-day and ongoing challenge for achieving sustainable agriculture. Pseudomonas fluorescens SF4c, native strain from wheat, produces tailocins (phage-tail-like bacteriocins) with antimicrobial activity against several phytopathogenic strains. We thus investigated the efficacy of foliar application of these bacteriocins to control the bacterial-spot disease in tomato caused by Xanthomonas vesicatoria Xcv Bv5-4a. The disease severity and incidence index were reduced by 44 and 36%, respectively; while the number of viable cells of X. vesicatoria Xcv Bv5-4a decreased after bacteriocin treatment. Furthermore, bacteriocin was effective in reducing bacterial-spot-disease symptoms on tomato fruits even when applied 12 h after infection. Tailocin activity was not affected by abiotic influences such as adjuvant, light and temperature and, biotic factors such as apoplastic-fluids. In contrast, no antibacterial activity of these tailocins was observed when the bacteriocin was exposed to extremely dry conditions. Finally, that no cytotoxic effects on mammalian cells were observed with this representative tailocins is highly significant and demonstrates the safety of such compounds in humans. All these findings indicate that the SF4c tailocins represent an attractive alternative to copper-containing bactericides for use in the control of bacterial spot. CI - Copyright © 2018 Elsevier GmbH. All rights reserved. FAU - Príncipe, Analía AU - Príncipe A AD - Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto-CONICET, Agencia Postal No. 3, X580BYA Río Cuarto, Córdoba, Argentina. FAU - Fernandez, Maricruz AU - Fernandez M AD - Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto-CONICET, Agencia Postal No. 3, X580BYA Río Cuarto, Córdoba, Argentina. FAU - Torasso, Milenka AU - Torasso M AD - Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto-CONICET, Agencia Postal No. 3, X580BYA Río Cuarto, Córdoba, Argentina. FAU - Godino, Agustina AU - Godino A AD - Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto-CONICET, Agencia Postal No. 3, X580BYA Río Cuarto, Córdoba, Argentina. FAU - Fischer, Sonia AU - Fischer S AD - Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto-CONICET, Agencia Postal No. 3, X580BYA Río Cuarto, Córdoba, Argentina. Electronic address: sfischer@exa.unrc.edu.ar. LA - eng PT - Journal Article DEP - 20180524 PL - Germany TA - Microbiol Res JT - Microbiological research JID - 9437794 RN - 0 (Anti-Bacterial Agents) RN - 0 (Bacteriocins) RN - 0 (Biological Control Agents) SB - IM MH - Animals MH - Anti-Bacterial Agents/biosynthesis/pharmacology MH - Antibiosis MH - Bacterial Infections/*drug therapy MH - Bacteriocins/chemistry/isolation & purification/metabolism/*pharmacology MH - Biological Control Agents/metabolism/pharmacology MH - Chlorocebus aethiops MH - Erythrocytes/drug effects MH - Light MH - Solanum lycopersicum/growth & development/*microbiology MH - Plant Diseases/*microbiology/*therapy MH - Plant Leaves/cytology/drug effects/microbiology MH - Pseudomonas fluorescens/*metabolism MH - Sheep MH - Temperature MH - Vero Cells/drug effects MH - Xanthomonas vesicatoria/*drug effects/pathogenicity OTO - NOTNLM OT - Bacteriocin OT - Biocontrol OT - Pseudomonas OT - Tailoicin OT - Tomato OT - Xanthomonas EDAT- 2018/06/02 06:00 MHDA- 2018/10/03 06:00 CRDT- 2018/06/02 06:00 PHST- 2017/12/22 00:00 [received] PHST- 2018/04/13 00:00 [revised] PHST- 2018/05/12 00:00 [accepted] PHST- 2018/06/02 06:00 [entrez] PHST- 2018/06/02 06:00 [pubmed] PHST- 2018/10/03 06:00 [medline] AID - S0944-5013(17)31266-1 [pii] AID - 10.1016/j.micres.2018.05.010 [doi] PST - ppublish SO - Microbiol Res. 2018 Jul-Aug;212-213:94-102. doi: 10.1016/j.micres.2018.05.010. Epub 2018 May 24. PMID- 32602761 OWN - NLM STAT- MEDLINE DCOM- 20220407 LR - 20220422 IS - 1471-1753 (Electronic) IS - 0954-6634 (Linking) VI - 33 IP - 2 DP - 2022 Mar TI - Dupilumab in pediatric dermatology. PG - 682-684 LID - 10.1080/09546634.2020.1789049 [doi] AB - BACKGROUND: Dupilumab is a monoclonal antibody that targets the interleukin (IL)-4 receptor alpha subunit of the IL-4 and IL-13 receptor. This novel agent has received a license for the treatment of moderate-to-severe atopic dermatitis in patients aged ≥12 years. However, data on the dupilumab use in the pediatric population are still extremely limited. This report aims to summarize the existing data on the on- and off-label use of dupilumab for dermatologic conditions in children and adolescents. MATERIALS AND METHODS: The current study is an overview of all the reported evidence on dupilumab for dermatologic conditions in the pediatric population. MEDLINE (PubMed), clinicaltrial.gov databases and SCOPUS were thoroughly scanned for related articles. RESULTS: A small number of clinical trials, case series and case reports, that indicate a satisfactory therapeutic outcome for dupilumab in pediatric patients for certain dermatologic conditions, is present in the literature. CONCLUSION: More long-term studies in larger patient groups are necessary so as to be able to draw definite conclusions concerning the efficacy and safety of dupilumab in pediatric patients with skin diseases. FAU - Plachouri, Kerasia-Maria AU - Plachouri KM AD - Dermatology Department, University of Patras, Greece, University General Hospital of Patras, Rio, Greece. FAU - Georgiou, Sophia AU - Georgiou S AD - Dermatology Department, University of Patras, Greece, University General Hospital of Patras, Rio, Greece. LA - eng PT - Journal Article PT - Review DEP - 20200707 PL - England TA - J Dermatolog Treat JT - The Journal of dermatological treatment JID - 8918133 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 420K487FSG (dupilumab) SB - IM MH - Adolescent MH - Antibodies, Monoclonal, Humanized/therapeutic use MH - Child MH - *Dermatitis, Atopic/drug therapy MH - *Dermatology MH - Humans MH - Severity of Illness Index MH - Treatment Outcome OTO - NOTNLM OT - Dupilumab OT - children OT - dermatology EDAT- 2020/07/01 06:00 MHDA- 2022/04/08 06:00 CRDT- 2020/07/01 06:00 PHST- 2020/07/01 06:00 [pubmed] PHST- 2022/04/08 06:00 [medline] PHST- 2020/07/01 06:00 [entrez] AID - 10.1080/09546634.2020.1789049 [doi] PST - ppublish SO - J Dermatolog Treat. 2022 Mar;33(2):682-684. doi: 10.1080/09546634.2020.1789049. Epub 2020 Jul 7. PMID- 38760101 OWN - NLM STAT- MEDLINE DCOM- 20240517 LR - 20240517 IS - 1474-4465 (Electronic) IS - 1474-4422 (Linking) VI - 23 IP - 6 DP - 2024 Jun TI - Climate change and disorders of the nervous system. PG - 636-648 LID - S1474-4422(24)00087-5 [pii] LID - 10.1016/S1474-4422(24)00087-5 [doi] AB - Anthropogenic climate change is affecting people's health, including those with neurological and psychiatric diseases. Currently, making inferences about the effect of climate change on neurological and psychiatric diseases is challenging because of an overall sparsity of data, differing study methods, paucity of detail regarding disease subtypes, little consideration of the effect of individual and population genetics, and widely differing geographical locations with the potential for regional influences. However, evidence suggests that the incidence, prevalence, and severity of many nervous system conditions (eg, stroke, neurological infections, and some mental health disorders) can be affected by climate change. The data show broad and complex adverse effects, especially of temperature extremes to which people are unaccustomed and wide diurnal temperature fluctuations. Protective measures might be possible through local forecasting. Few studies project the future effects of climate change on brain health, hindering policy developments. Robust studies on the threats from changing climate for people who have, or are at risk of developing, disorders of the nervous system are urgently needed. CI - Copyright © 2024 Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies. FAU - Sisodiya, Sanjay M AU - Sisodiya SM AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK; Chalfont Centre for Epilepsy, Chalfont-St-Peter, UK. Electronic address: s.sisodiya@ucl.ac.uk. FAU - Gulcebi, Medine I AU - Gulcebi MI AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK; Chalfont Centre for Epilepsy, Chalfont-St-Peter, UK. FAU - Fortunato, Francesco AU - Fortunato F AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK; Chalfont Centre for Epilepsy, Chalfont-St-Peter, UK. FAU - Mills, James D AU - Mills JD AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK; Chalfont Centre for Epilepsy, Chalfont-St-Peter, UK. FAU - Haynes, Ethan AU - Haynes E AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK; Chalfont Centre for Epilepsy, Chalfont-St-Peter, UK. FAU - Bramon, Elvira AU - Bramon E AD - Division of Psychiatry, University College London, London, UK. FAU - Chadwick, Paul AU - Chadwick P AD - Centre for Behaviour Change, University College London, London, UK. FAU - Ciccarelli, Olga AU - Ciccarelli O AD - Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. FAU - David, Anthony S AU - David AS AD - Division of Psychiatry, University College London, London, UK. FAU - De Meyer, Kris AU - De Meyer K AD - UCL Climate Action Unit, University College London, London, UK. FAU - Fox, Nick C AU - Fox NC AD - Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK; Department of the UK Dementia Research Institute, UCL Queen Square Institute of Neurology, University College London, London, UK. FAU - Davan Wetton, Joanna AU - Davan Wetton J AD - Centre for Behaviour Change, University College London, London, UK. FAU - Koltzenburg, Martin AU - Koltzenburg M AD - Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK. FAU - Kullmann, Dimitri M AU - Kullmann DM AD - Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK. FAU - Kurian, Manju A AU - Kurian MA AD - Department of Developmental Neurosciences, Zayed Centre for Research into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Manji, Hadi AU - Manji H AD - National Hospital for Neurology and Neurosurgery, London, UK. FAU - Maslin, Mark A AU - Maslin MA AD - Department of Geography, University College London, London, UK; Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark. FAU - Matharu, Manjit AU - Matharu M AD - Headache and Facial Pain Group, UCL Queen Square Institute of Neurology, UCL and the National Hospital for Neurology and Neurosurgery, London, UK. FAU - Montgomery, Hugh AU - Montgomery H AD - Department of Medicine, University College London, London, UK. FAU - Romanello, Marina AU - Romanello M AD - Institute for Global Health, University College London, London, UK. FAU - Werring, David J AU - Werring DJ AD - Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, UK. FAU - Zhang, Lisa AU - Zhang L AD - Centre for Behaviour Change, University College London, London, UK. FAU - Friston, Karl J AU - Friston KJ AD - Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, UK. FAU - Hanna, Michael G AU - Hanna MG AD - Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK; MRC International Centre for Genomic Medicine in Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK. LA - eng PT - Journal Article PT - Review PL - England TA - Lancet Neurol JT - The Lancet. Neurology JID - 101139309 SB - IM MH - Humans MH - *Climate Change MH - *Nervous System Diseases/epidemiology COIS- Declaration of interests HMo chairs Dyson's Scientific Advisory Board and the Lancet Countdown on Health and Climate Change; holds a patent relating to a means to improve patient hydration in hospitals; is a member of the UK Climate and Health Council; is a cofounder of Real Zero (a non-profit company helping decarbonise health care); and has received honoraria for talks on climate change, but none for talks related to the topic of this Personal View. NCF is the member of the Research Strategy Council of Alzheimer's Society (UK). DJW has received grant funding from the Stroke Association and British Heart Foundation; speaking honoraria from Bayer; speaking and chairing honoraria from Alexion and NovoNordisk; and consultancy fees from Alnylam, Bayer, and NovoNordisk. DW has also participated on a data safety monitoring board for OXHARP, and the TICH-3, RESTART, MACE-ICH, and PLINTH Trial Steering Committees. MAK has received payments from Bloomsbury Genetic Therapies and PTC; holds shares in Bloomsbury Genetic Therapies (unrelated to this work as involvement pertains to the development of gene therapies for rare neurometabolic disorders); has leadership or fiduciary role in LifeArc grants committee (not relevant to this work as this membership pertains to the review of grants and allocation of funding through the Philanthropic fund); is the theme lead for the National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre Accelerating Novel Therapies; and has patents, issued or pending, for DTDS viral vector. OC reports speaking honoraria from Merck and Biogen and for participation on a data safety monitoring board for Novartis. MM has grants or contracts from Ehlers Danlos Society, Abbott, and Medtronic; reports consulting fees from AbbVie, Kriya, TEVA, Lundbeck, Eli Lilly, Salvia, and Pfizer, all paid to their institution; reports payment or honoraria for lectures, presentations, speakers bureaux, manuscript writing, or educational events from AbbVie, Pfizer, and Eli Lilly; reports patents (planned, issued, or pending) for WO2018051103A1: System and method for diagnosing and treating headaches; and is the president of the medical advisory board of CSF Leak Association and a board member of the Anglo Dutch Migraine Association. All other authors declare no competing interests. EDAT- 2024/05/18 04:22 MHDA- 2024/05/18 04:23 CRDT- 2024/05/17 20:56 PHST- 2023/11/17 00:00 [received] PHST- 2024/02/12 00:00 [revised] PHST- 2024/02/27 00:00 [accepted] PHST- 2024/05/18 04:23 [medline] PHST- 2024/05/18 04:22 [pubmed] PHST- 2024/05/17 20:56 [entrez] AID - S1474-4422(24)00087-5 [pii] AID - 10.1016/S1474-4422(24)00087-5 [doi] PST - ppublish SO - Lancet Neurol. 2024 Jun;23(6):636-648. doi: 10.1016/S1474-4422(24)00087-5. PMID- 23382003 OWN - NLM STAT- MEDLINE DCOM- 20140207 LR - 20171116 IS - 1526-4998 (Electronic) IS - 1526-498X (Linking) VI - 69 IP - 9 DP - 2013 Sep TI - Cyflumetofen, a novel acaricide - its mode of action and selectivity. PG - 1080-4 LID - 10.1002/ps.3470 [doi] AB - BACKGROUND: Cyflumetofen is a novel acaricide developed by Otsuka AgriTechno Co., Ltd. It affects only spider mites and has no effect on insects, crustaceans or vertebrates under conditions of practical use. The mode of action of cyflumetofen, its selectivity for mites and its safety for insects and vertebrates were investigated. RESULTS: The research showed that cyflumetofen inhibited mitochondria complex II in mites. In addition, the de-esterified form (AB-1) of cyflumetofen inhibited mitochondria complex II at extremely low concentrations. AB-1 was also detected as the main metabolite in mites. CONCLUSION: The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities. CI - © 2012 Society of Chemical Industry. FAU - Hayashi, Naotaka AU - Hayashi N AD - Otsuka AgriTechno Co., Ltd, Naruto Research Centre, Naruto, Tokushima, Japan. naotaka-hayashi@otsuka.agritechno.jp FAU - Sasama, Yasuhiro AU - Sasama Y FAU - Takahashi, Nobuyoshi AU - Takahashi N FAU - Ikemi, Naoki AU - Ikemi N LA - eng PT - Journal Article DEP - 20130205 PL - England TA - Pest Manag Sci JT - Pest management science JID - 100898744 RN - 0 (Acaricides) RN - 0 (Arthropod Proteins) RN - 0 (Propionates) RN - QJW6N27119 (cyflumetofen) SB - IM MH - Acaricides/*toxicity MH - Animals MH - Arthropod Proteins/genetics/metabolism MH - Insecta/drug effects MH - Propionates/*toxicity MH - Species Specificity MH - Tetranychidae/*drug effects/genetics/metabolism OTO - NOTNLM OT - IPM OT - complex II inhibitor OT - cyflumetofen OT - mites OT - mode of action EDAT- 2013/02/06 06:00 MHDA- 2014/02/08 06:00 CRDT- 2013/02/06 06:00 PHST- 2012/06/04 00:00 [received] PHST- 2012/11/06 00:00 [revised] PHST- 2012/12/11 00:00 [accepted] PHST- 2013/02/06 06:00 [entrez] PHST- 2013/02/06 06:00 [pubmed] PHST- 2014/02/08 06:00 [medline] AID - 10.1002/ps.3470 [doi] PST - ppublish SO - Pest Manag Sci. 2013 Sep;69(9):1080-4. doi: 10.1002/ps.3470. Epub 2013 Feb 5. PMID- 8423118 OWN - NLM STAT- MEDLINE DCOM- 19930224 LR - 20190920 IS - 0266-4623 (Print) IS - 0266-4623 (Linking) VI - 9 IP - 1 DP - 1993 Winter TI - Perspectives on health technology assessment in Latin America. The case of perinatal care in the literature. PG - 76-84 AB - The possibility of referring to the medical literature to support technology assessments in perinatal care was studied by examining more than 40,000 references contained in the Index Medicus of Latin America for the period 1984-88. A total of 1,074 references addressed perinatal technologies, but with irregular distribution. Information on effectiveness, safety, costs, and social impact of perinatal technologies was extremely limited. These results led to the conclusion that immediate action needs to be taken to create the necessary conditions for health technology assessment in Latin America. FAU - Panerai, R B AU - Panerai RB AD - Federal University of Rio de Janeiro. FAU - Almeida, R T AU - Almeida RT FAU - Freire, S M AU - Freire SM FAU - Chaim, D M AU - Chaim DM FAU - Miranda, M Z AU - Miranda MZ FAU - Madureira, L C AU - Madureira LC FAU - Aguiar Neto, M A AU - Aguiar Neto MA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Int J Technol Assess Health Care JT - International journal of technology assessment in health care JID - 8508113 SB - IM MH - Developing Countries MH - Humans MH - Infant, Newborn MH - Latin America MH - MEDLARS MH - *Perinatology MH - Policy Making MH - Publishing MH - Research Design MH - Technology Assessment, Biomedical/*statistics & numerical data RF - 16 EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1017/s0266462300003044 [doi] PST - ppublish SO - Int J Technol Assess Health Care. 1993 Winter;9(1):76-84. doi: 10.1017/s0266462300003044. PMID- 28278501 OWN - NLM STAT- MEDLINE DCOM- 20171030 LR - 20171030 IS - 1660-5535 (Electronic) IS - 1660-5527 (Linking) VI - 30 IP - 2 DP - 2017 TI - Standardization of an in vitro Model for Evaluating the Bioavailability of Topically Applied Compounds on Damaged Skin: Application to Sunscreen Analysis. PG - 55-65 LID - 10.1159/000455196 [doi] AB - BACKGROUND: Information is lacking on the dermal penetration of topically applied formulations on in vitro skin models, under conditions where the stratum corneum (SC) is damaged. Therefore, we have developed a standardized in vitro barrier-disrupted skin model using tape stripping. METHODS: Different tape stripping conditions were evaluated using histology, transepidermal water loss, infrared densitometry, and caffeine absorption. RESULTS: The effects of tape stripping were comparable using pig and human skin. Optimized conditions were used to test the effect of SC damage and UV irradiation on the absorption of an UV filter combination present in a sunscreen. The bioavailability of the filters was extremely low regardless of the extent of skin damage, suggesting bioavailability would not be increased if the consumer applied the sunscreen to sun-damaged skin. CONCLUSION: This standardized in vitro methodology using pig or human skin for damaged skin will add valuable information for the safety assessment of topically applied products. CI - © 2017 S. Karger AG, Basel. FAU - Jacques-Jamin, Carine AU - Jacques-Jamin C AD - Pharmacologie Division 2 et Pharmacocinétique Cutanée, Centre R&D Pierre Fabre, Pierre Fabre Dermo-Cosmétique, Toulouse, France. FAU - Jeanjean-Miquel, Corinne AU - Jeanjean-Miquel C FAU - Domergue, Anaïs AU - Domergue A FAU - Bessou-Touya, Sandrine AU - Bessou-Touya S FAU - Duplan, Hélène AU - Duplan H LA - eng PT - Journal Article DEP - 20170310 PL - Switzerland TA - Skin Pharmacol Physiol JT - Skin pharmacology and physiology JID - 101188418 RN - 0 (Sunscreening Agents) RN - 3G6A5W338E (Caffeine) SB - IM MH - Administration, Cutaneous MH - Adult MH - Animals MH - Biological Availability MH - Caffeine/pharmacokinetics MH - Chemistry, Pharmaceutical MH - Densitometry MH - Female MH - Humans MH - In Vitro Techniques MH - Middle Aged MH - *Models, Biological MH - Skin/*pathology MH - *Skin Absorption MH - Species Specificity MH - Sunscreening Agents/administration & dosage/*pharmacokinetics MH - Swine MH - Ultraviolet Rays/adverse effects MH - Water Loss, Insensible OTO - NOTNLM OT - Barrier-disrupted skin model OT - Bioavailability OT - Human OT - Pig OT - Standardized model OT - Sunscreen filters OT - Tape stripping EDAT- 2017/03/10 06:00 MHDA- 2017/10/31 06:00 CRDT- 2017/03/10 06:00 PHST- 2016/08/05 00:00 [received] PHST- 2016/12/19 00:00 [accepted] PHST- 2017/03/10 06:00 [pubmed] PHST- 2017/10/31 06:00 [medline] PHST- 2017/03/10 06:00 [entrez] AID - 000455196 [pii] AID - 10.1159/000455196 [doi] PST - ppublish SO - Skin Pharmacol Physiol. 2017;30(2):55-65. doi: 10.1159/000455196. Epub 2017 Mar 10. PMID- 22147286 OWN - NLM STAT- MEDLINE DCOM- 20120914 LR - 20220317 IS - 1468-2052 (Electronic) IS - 1359-2998 (Linking) VI - 97 IP - 4 DP - 2012 Jul TI - Oral versus intravenous ibuprofen for patent ductus arteriosus closure: a randomised controlled trial in extremely low birthweight infants. PG - F279-83 LID - 10.1136/archdischild-2011-300532 [doi] AB - OBJECTIVE: To compare the efficacy and safety of oral versus intravenous ibuprofen for the pharmacological closure of patent ductus arteriosus (PDA) in less mature preterm infants. DESIGN: Prospective, randomised controlled study. SETTING: Tertiary neonatal intensive care unit. PATIENTS AND INTERVENTIONS: The study enrolled 80 preterm infants with gestational age ≤28 weeks, birth weight <1000 g, postnatal age 48 to 96 h, and had echocardiographically confirmed significant PDA. Seventy extremely low birthweight (ELBW) preterm infants received either intravenous or oral ibuprofen randomly as an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 h. MAIN OUTCOME MEASURES: The success rate and the safety of the drugs in ELBW preterm infants were the major outcomes. RESULTS: PDA closure rate was significantly higher with oral ibuprofen (83.3% vs 61.7%) after the first course of the treatment (p=0.04). Although the primary closure rate was marginally higher in the oral ibuprofen group, the need for a second course of ibuprofen during the whole hospitalisation was similar between groups: 11 of 36 in oral versus 15 of 34 in intravenous groups (p=0.24) because of a higher reopening rate in the oral group. In addition to no increase in side effects with oral ibuprofen use, the need for postnatal steroid use for chronic lung disease was significantly lower in oral ibuprofen group (p=0.001). CONCLUSIONS: Oral ibuprofen is as effective as intravenous ibuprofen for PDA closure even in ELBW infants. FAU - Erdeve, Omer AU - Erdeve O AD - Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. omererdeve@yahoo.com FAU - Yurttutan, Sadik AU - Yurttutan S FAU - Altug, Nahide AU - Altug N FAU - Ozdemir, Ramazan AU - Ozdemir R FAU - Gokmen, Tulin AU - Gokmen T FAU - Dilmen, Ugur AU - Dilmen U FAU - Oguz, Serife Suna AU - Oguz SS FAU - Uras, Nurdan AU - Uras N LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20111205 PL - England TA - Arch Dis Child Fetal Neonatal Ed JT - Archives of disease in childhood. Fetal and neonatal edition JID - 9501297 RN - 0 (Cyclooxygenase Inhibitors) RN - WK2XYI10QM (Ibuprofen) SB - IM MH - Administration, Oral MH - Birth Weight MH - Chronic Disease MH - Cyclooxygenase Inhibitors/*administration & dosage/adverse effects/therapeutic use MH - Ductus Arteriosus, Patent/*drug therapy MH - Female MH - Gestational Age MH - Humans MH - Ibuprofen/*administration & dosage/adverse effects/therapeutic use MH - *Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Infant, Premature MH - Infusions, Intravenous MH - Intensive Care, Neonatal/methods MH - Lung Diseases/chemically induced MH - Male MH - Treatment Outcome EDAT- 2011/12/08 06:00 MHDA- 2012/09/15 06:00 CRDT- 2011/12/08 06:00 PHST- 2011/12/08 06:00 [entrez] PHST- 2011/12/08 06:00 [pubmed] PHST- 2012/09/15 06:00 [medline] AID - archdischild-2011-300532 [pii] AID - 10.1136/archdischild-2011-300532 [doi] PST - ppublish SO - Arch Dis Child Fetal Neonatal Ed. 2012 Jul;97(4):F279-83. doi: 10.1136/archdischild-2011-300532. Epub 2011 Dec 5. PMID- 28261647 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240808 IS - 2366-1070 (Print) IS - 2366-1089 (Electronic) IS - 2366-1089 (Linking) VI - 4 IP - 2 DP - 2016 TI - Biosimilar Oncology Drugs in Europe: Regulatory and Pharmacovigilance Considerations. PG - 173-182 LID - 10.1007/s40487-016-0028-9 [doi] AB - The introduction in clinical practice of pharmaceutical products known as biosimilars, as part of a more complex series of progress in the field of biological drugs, represents an excellent therapeutic resource. A biosimilar drug is a biological/biotechnological drug that is highly similar to an approved reference biologic product. Given their complexity, biosimilars require attention and a continued vigilance to ensure appropriate use, especially in cancer therapy. There is the urgent need, both at Italian and European levels, of clear and more comprehensive guidelines to elucidate the open questions. Probably, the acquisition of new data, obtained from larger samples of patients than those used in the pre-approval studies and with extremely variable clinical conditions, will allow clarifying the extent to which biosimilar drugs are similar in safety and efficacy to their biologic reference drug. The aims of this article are to provide health professionals with basic, but essential information about biosimilars, and to identify current critical points and future perspectives for clinical practice, cancer care, regulatory aspects, and pharmacovigilance. FAU - Francescon, Sara AU - Francescon S AUID- ORCID: 0000-0001-8042-7773 AD - Pharmacy Division, CRO National Cancer Institute, Aviano, Italy. FAU - Fornasier, Giulia AU - Fornasier G AD - Pharmacy Division, CRO National Cancer Institute, Aviano, Italy. FAU - Baldo, Paolo AU - Baldo P AD - Pharmacy Division, CRO National Cancer Institute, Aviano, Italy. LA - eng PT - Journal Article PT - Review DEP - 20160811 PL - New Zealand TA - Oncol Ther JT - Oncology and therapy JID - 101677510 PMC - PMC5315076 OTO - NOTNLM OT - Biosimilars OT - Europe OT - Oncology OT - Pharmacovigilance EDAT- 2016/01/01 00:00 MHDA- 2016/01/01 00:01 PMCR- 2016/08/11 CRDT- 2017/03/07 06:00 PHST- 2016/05/26 00:00 [received] PHST- 2017/03/07 06:00 [entrez] PHST- 2016/01/01 00:00 [pubmed] PHST- 2016/01/01 00:01 [medline] PHST- 2016/08/11 00:00 [pmc-release] AID - 28 [pii] AID - 10.1007/s40487-016-0028-9 [doi] PST - ppublish SO - Oncol Ther. 2016;4(2):173-182. doi: 10.1007/s40487-016-0028-9. Epub 2016 Aug 11. PMID- 12095477 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 1092-8472 (Print) IS - 1092-8472 (Linking) VI - 5 IP - 4 DP - 2002 Aug TI - Serotonergic Agents in the Treatment of Functional Gastrointestinal Disorders. PG - 293-300 AB - Functional gastrointestinal disorders are exceptionally common, cause a great deal of suffering, and are extremely challenging to treat. Current therapies, usually targeted at possible abnormalities of gut contractility, are often disappointing and there is a real need for a new approach to treatment. Over the last decade, there has been an increase in our understanding of potential pathophysiologic processes involved in these conditions resulting in novel therapeutic agents based on this information. Serotonin receptor modulators are one such example of this approach, but their development has met with a number of difficulties mainly centered around issues of safety and trial design. It is becoming increasingly apparent that a drug universally effective in all forms of functional gastrointestinal disorders is unlikely to emerge unless some centrally acting compound can achieve this goal. Thus, the current approach of targeting specific subgroups is probably the best strategy. Many patients with functional gastrointestinal disorders do not even bother to consult the medical profession because of the lack of benefit from any currently available treatments. Thus, if a new effective drug is developed, even for a subgroup, demand is likely to be substantial, leading to an even greater burden on already stretched drug budgets. FAU - Lea, Richard AU - Lea R AD - Department of Academic Medicine, Education and Research Centre, South Manchester, University Hospitals, Manchester, UK. richardlea001@aol.com FAU - Whorwell, Peter J AU - Whorwell PJ LA - eng PT - Journal Article PL - United States TA - Curr Treat Options Gastroenterol JT - Current treatment options in gastroenterology JID - 9815941 EDAT- 2002/07/04 10:00 MHDA- 2002/07/04 10:01 CRDT- 2002/07/04 10:00 PHST- 2002/07/04 10:00 [pubmed] PHST- 2002/07/04 10:01 [medline] PHST- 2002/07/04 10:00 [entrez] AID - 10.1007/s11938-002-0052-8 [doi] PST - ppublish SO - Curr Treat Options Gastroenterol. 2002 Aug;5(4):293-300. doi: 10.1007/s11938-002-0052-8. PMID- 30510915 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 8 DP - 2018 TI - Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials. PG - 484 LID - 10.3389/fonc.2018.00484 [doi] LID - 484 AB - Chemotherapy-induced oral mucositis is an extremely serious complication faced by cancer patients. The role of oral zinc sulfate in preventing and treating chemotherapy-induced oral mucositis remains a subject of debate. The aim of this systematic review is to assess the potential of oral zinc sulfate to alleviate this morbid condition. A systematic search was conducted electronically in PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) to capture all potential randomized controlled trials investigating efficacy and safety of oral zinc sulfate in prevention and treatment of chemotherapy-induced oral mucositis, and the retrieval time was limited from their inception to April 2018. We assigned two independent investigators to perform a search, screen citations, extract information, and evaluate the risk of bias in all included trials. Subsequently, the RevMan 5.3 software was utilized to perform all statistical analyses. We included five eligible studies involving 352 patients. Meta-analysis based on limited data revealed that oral zinc sulfate failed to decrease the incidence of chemotherapy-induced oral mucositis (RR [relative risk] = 0.52, 95% CI [confidence interval] = 0.17-1.64) as well as relieve chemotherapy-induced oral mucositits grade (RR = 0.62, 95% CI = 0.11-3.56; RR = 0.70, 95% CI = 0.29-1.71). Moreover, qualitative analyses also suggested that oral zinc sulfate was not associated with reduced oral pain intensity, delayed onset of chemotherapy-induced oral mucositis, decreased adverse events, or improved quality of life compared with control regimes. Oral zinc sulfate may not provide clinical benefits in preventing or reducing incidence, severity, or pain intensity of chemotherapy-induced oral mucositis in cancer patients. However, more studies with large-scale and rigorous methods are warranted for the purpose of further investigating efficacy and safety of oral zinc sulfate for this pathologic condition due to the presence of limitations. FAU - Tian, Xu AU - Tian X AD - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Gastroenterology, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China. AD - Editorial Office, TMR Integrative Nursing, TMR Publishing Group, Tianjin, China. FAU - Liu, Xiao-Ling AU - Liu XL AD - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Gastroenterology, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China. FAU - Pi, Yuan-Ping AU - Pi YP AD - Key Laboratory for Biorheological Science and Technology of Ministry of Education, Department of Nursing, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China. FAU - Chen, Hui AU - Chen H AD - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Gastroenterology, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China. FAU - Chen, Wei-Qing AU - Chen WQ AD - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Gastroenterology, Chongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, China. LA - eng PT - Journal Article DEP - 20181119 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC6252385 OTO - NOTNLM OT - chemotherapy OT - meta-analysis OT - oral mucositis OT - systematic review OT - zinc sulfate EDAT- 2018/12/05 06:00 MHDA- 2018/12/05 06:01 PMCR- 2018/01/01 CRDT- 2018/12/05 06:00 PHST- 2018/07/30 00:00 [received] PHST- 2018/10/09 00:00 [accepted] PHST- 2018/12/05 06:00 [entrez] PHST- 2018/12/05 06:00 [pubmed] PHST- 2018/12/05 06:01 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - 10.3389/fonc.2018.00484 [doi] PST - epublish SO - Front Oncol. 2018 Nov 19;8:484. doi: 10.3389/fonc.2018.00484. eCollection 2018. PMID- 27538261 OWN - NLM STAT- MEDLINE DCOM- 20171004 LR - 20171004 IS - 1442-200X (Electronic) IS - 1328-8067 (Linking) VI - 59 IP - 3 DP - 2017 Mar TI - Safety of Bifidobacterium breve (BBG-01) in preterm infants. PG - 328-333 LID - 10.1111/ped.13123 [doi] AB - BACKGROUND: Since 1982, viable cells of Bifidobacterium breve (BBG-01) have been used in pediatric patients for clinical conditions such as intractable infantile diarrhea, preterm status, and pediatric surgery. Although the efficacy of BBG-01 has been widely reported, adverse events related to the use of BBG-01 have been reported in very few cases. METHODS: In order to trace adverse events seen by 109 doctors in 88 medical institutions where BBG-01 was used, a questionnaire survey of the number of occurrences and details of each case was conducted. RESULTS: Eighty-six clinicians (70 institutions) responded to the questionnaire (response rate, 78.9%). Number of respondents according to department of diagnosis (no. BBG-01-treated infants) was as follows: pediatrics, 29 respondents (10 938 patients); premature and newborn medicine, 26 (10 677 patients); obstetrics and gynecology, 1 (1212 patients) and pediatric surgery, 22 (169 patients). More than 90% of the total BBG-01-treated patients (23 092 patients) were in the departments of premature and newborn medicine and pediatrics, and BBG-01 had been used mainly in preterm infants and children with intractable diarrhea. Adverse events occurred in two extremely premature infants with functional ileus due to starch aggregates as vehicle, and in two surgical neonates with bacteremia caused by B. breve genetically identical to BBG-01, and no serious adverse events with poor outcome were reported. CONCLUSION: Adverse events related to the use of BBG-01 have an extremely low incidence and are mild in severity, thus ensuring the superior safety of this preparation. CI - © 2016 Japan Pediatric Society. FAU - Kitajima, Hiroyuki AU - Kitajima H AD - Department of Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan. FAU - Hirano, Shinya AU - Hirano S AD - Department of Neonatal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan. LA - eng PT - Journal Article DEP - 20161117 PL - Australia TA - Pediatr Int JT - Pediatrics international : official journal of the Japan Pediatric Society JID - 100886002 SB - IM MH - *Bifidobacterium breve MH - Diarrhea, Infantile/*therapy MH - Female MH - Health Care Surveys MH - Humans MH - Infant, Newborn MH - Infant, Premature MH - Infant, Premature, Diseases/*therapy MH - Japan MH - Male MH - Practice Patterns, Physicians'/statistics & numerical data MH - Probiotics/*adverse effects/therapeutic use MH - Retrospective Studies MH - Treatment Outcome OTO - NOTNLM OT - Bifidobacterium breve OT - BBG-01 OT - preterm infant OT - probiotic EDAT- 2016/08/19 06:00 MHDA- 2017/10/05 06:00 CRDT- 2016/08/19 06:00 PHST- 2015/11/20 00:00 [received] PHST- 2016/08/11 00:00 [revised] PHST- 2016/08/15 00:00 [accepted] PHST- 2016/08/19 06:00 [pubmed] PHST- 2017/10/05 06:00 [medline] PHST- 2016/08/19 06:00 [entrez] AID - 10.1111/ped.13123 [doi] PST - ppublish SO - Pediatr Int. 2017 Mar;59(3):328-333. doi: 10.1111/ped.13123. Epub 2016 Nov 17. PMID- 34688736 OWN - NLM STAT- MEDLINE DCOM- 20220120 LR - 20220120 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 809 DP - 2022 Feb 25 TI - Flood signals in tree-ring δ(18)O and wood anatomical parameters of Lagerstroemia speciosa: Implications for developing flood management strategies in Bangladesh. PG - 151125 LID - S0048-9697(21)06203-3 [pii] LID - 10.1016/j.scitotenv.2021.151125 [doi] AB - Bangladesh consists of 80% of the flood plain of the Ganges-Brahmaputra-Meghna river system (GBM), making the country one of the highest flood prone countries of the world. Due to the high rate of discharge of the GBM caused by the summer monsoon and the snowmelt of the Eastern Himalaya and Southern Tibetan Plateau due to climate change, Bangladesh witnessed 16 flood events over 1954-2017. We performed a multiproxy tree-ring analysis to investigate the impact of extreme flood events on tree growth, xylem anatomical parameters and oxygen isotope composition of tree-ring cellulose (δ(18)O(tr)) in a Bangladeshi moist tropical forest and to establish relationships between water level of the regional rivers and tree-ring parameters. By using pointer year analysis and comparing the pointer years with historical flood records (a cut-off threshold of the country's flooded land area of 33.3%), we identified the three extreme flood events (hereafter called flood years) 1974, 1988, and 1998 in Bangladesh. Superposed epoch analysis revealed significant changes in Tree-ring width (TRW), total vessel area (TVA), vessel density (VD), and δ(18)O(tr) during flood years. Flood associated hypoxic soil conditions reduced TRW up to 53% and TVA up to 28%, varying with flood events. In contrast, VD increased by 23% as a safety mechanism against flood induced hydraulic failure. Tree-ring δ(18)O significantly decreased during the flood years due to the amount effect in regional precipitation. Bootstrapped Pearson correlation analysis showed that wood anatomical variables encoded stronger river level signals than TRW and δ(18)O(tr). Among the wood anatomical parameters, VD showed a strong relationship (r = -0.58, p < 0.01) with the water level of the Manu River, a regional river of the north-eastern part of Bangladesh, indicating that VD can be used as a reliable proxy for river level reconstruction. Our analyses suggest that multiproxy tree-ring analysis is a potential tool to study tropical moist forest responses to extreme flood events and to identify suitable proxies for reconstructing hydrological characteristics of South Asian rivers. CI - Copyright © 2021 Elsevier B.V. All rights reserved. FAU - Rahman, Mizanur AU - Rahman M AD - Department of Forestry and Environmental Science, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh; Institute of Geography, Friedrich-Alexander University Erlangen-Nuremberg, Wetterkreuz 15, 91058 Erlangen, Germany. Electronic address: mizan-for@sust.edu. FAU - Islam, Mahmuda AU - Islam M AD - Department of Forestry and Environmental Science, Shahjalal University of Science and Technology, Sylhet 3114, Bangladesh; Institute of Geography, Friedrich-Alexander University Erlangen-Nuremberg, Wetterkreuz 15, 91058 Erlangen, Germany. FAU - Masood, Muhammad AU - Masood M AD - Design Circle-9, Bangladesh Water Development Board (BWDB), Pani Bhaban, 72, Green Road, Dhaka 1215, Bangladesh. FAU - Gebrekirstos, Aster AU - Gebrekirstos A AD - Institute of Geography, Friedrich-Alexander University Erlangen-Nuremberg, Wetterkreuz 15, 91058 Erlangen, Germany; World Agroforestry Centre (ICRAF), United Nations Avenue, P.O. Box 30677-00100, Nairobi, Kenya. FAU - Bräuning, Achim AU - Bräuning A AD - Institute of Geography, Friedrich-Alexander University Erlangen-Nuremberg, Wetterkreuz 15, 91058 Erlangen, Germany. LA - eng PT - Journal Article DEP - 20211022 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - Bangladesh MH - *Floods MH - *Lagerstroemia MH - Trees MH - Wood OTO - NOTNLM OT - Extreme flood events OT - Floods in Bangladesh OT - Multiproxy tree-ring analysis OT - River hydrology OT - Tree-ring δ(18)O OT - Wood anatomical parameters COIS- Declaration of competing interest We declare that the authors of the manuscript titled “Flood signals in tree-ring δ(18)O and xylem anatomical parameters of Lagerstroemia speciosa: Implications for developing flood management strategies in Bangladesh” submitted to Science of the Total Environment, have no conflict of interest. EDAT- 2021/10/25 06:00 MHDA- 2022/01/21 06:00 CRDT- 2021/10/24 20:34 PHST- 2021/05/04 00:00 [received] PHST- 2021/10/16 00:00 [revised] PHST- 2021/10/17 00:00 [accepted] PHST- 2021/10/25 06:00 [pubmed] PHST- 2022/01/21 06:00 [medline] PHST- 2021/10/24 20:34 [entrez] AID - S0048-9697(21)06203-3 [pii] AID - 10.1016/j.scitotenv.2021.151125 [doi] PST - ppublish SO - Sci Total Environ. 2022 Feb 25;809:151125. doi: 10.1016/j.scitotenv.2021.151125. Epub 2021 Oct 22. PMID- 38282861 OWN - NLM STAT- MEDLINE DCOM- 20240130 LR - 20241023 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 12 DP - 2024 TI - Comparison design and evaluation power in cohort and self-controlled case series designs for post-authorization vaccine safety studies. PG - e16780 LID - 10.7717/peerj.16780 [doi] LID - e16780 AB - BACKGROUND: Post-authorization safety studies (PASSs) of vaccines are important. PASSs enable the evaluation of association between vaccination and adverse events following immunization through common study designs. Clinical trials during vaccine development typically include a few thousand to 10,000 participants while a PASS might aim to detect a few adverse events per 100,000 vaccine recipients. While all available data may be utilized, prior consideration of power analyses are nonetheless crucial for interpretation in cases where statistically significant differences are not found. METHODS: This research primarily examined cohort study design and self-controlled case series (SCCS) design, estimating the power of a PASS under plausible conditions. RESULTS: Both the cohort study and SCCS designs necessitated large sample sizes or high event counts to guarantee adequate power. The SCCS design is particularly suited to evaluating rare adverse events. However, extremely rare events may not yield sufficient occurrences, thereby resulting in low power. Although the SCCS design can more efficiently control for time-invariant confounding in principle, it solely estimates relative measures. A cohort study design might be preferred if confounding can be adequately managed as it also estimates absolute measures. It may be an easy decision to use all the data at hand for either design. We found it necessary to estimate the sample size and number of events to be used in the study based on a priori information and anticipated results. CI - ©2024 Sato et al. FAU - Sato, Shuntaro AU - Sato S AD - Clinical Research Center, Nagasaki University, Nagasaki, Japan. FAU - Kawazoe, Yurika AU - Kawazoe Y AD - Clinical Research Center, Nagasaki University, Nagasaki, Japan. FAU - Katsuta, Tomohiro AU - Katsuta T AD - Department of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan. FAU - Fukuda, Haruhisa AU - Fukuda H AD - Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. AD - Center for Cohort Studies/Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. LA - eng PT - Journal Article DEP - 20240123 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Cohort Studies MH - *Immunization/adverse effects MH - Research Design MH - *Vaccination/adverse effects PMC - PMC10812582 OTO - NOTNLM OT - Post-authorization vaccine safety studies OT - Power analysis OT - Self-controlled case series design COIS- Shuntaro Sato reports personal fees from Nippon Boehringer Ingelheim Co., Ltd, outside the submitted work; Tomohiro Katsuta received payment for lectures from Merck Sharp & Dohme Corp. The other authers declare that they have no competing interests. EDAT- 2024/01/29 06:44 MHDA- 2024/01/30 12:43 PMCR- 2024/01/23 CRDT- 2024/01/29 04:09 PHST- 2023/08/15 00:00 [received] PHST- 2023/12/18 00:00 [accepted] PHST- 2024/01/30 12:43 [medline] PHST- 2024/01/29 06:44 [pubmed] PHST- 2024/01/29 04:09 [entrez] PHST- 2024/01/23 00:00 [pmc-release] AID - 16780 [pii] AID - 10.7717/peerj.16780 [doi] PST - epublish SO - PeerJ. 2024 Jan 23;12:e16780. doi: 10.7717/peerj.16780. eCollection 2024. PMID- 34961551 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211230 IS - 2520-1026 (Electronic) IS - 2520-1026 (Linking) VI - 5 IP - 1 DP - 2021 Dec 28 TI - Macrophage activation syndrome in a patient with adult-onset Still's disease following first COVID-19 vaccination with BNT162b2. PG - 60 LID - 10.1186/s41927-021-00237-9 [doi] LID - 60 AB - BACKGROUND: Adult-onset Still's disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10-20%. Especially viral infection is thought to be a common trigger for development of MAS. On the other hand, the occurrence of MAS following vaccinations is extremely rare and has been described in a few cases after measles or influenza vaccinations and more recently after ChAdOx1 nCoV-19 (COVID-19 viral vector vaccine, Oxford-AZ). CASE PRESENTATION: We report the case of a twenty-year-old female with adult-onset Still's disease (AOSD), who developed a MAS six days after receiving her first COVID-19 vaccine dose of BNT162b2 (mRNA vaccine, BioNTech/Pfizer) with ferritin levels of 136,680 µg/l (ref.: 13-150 µg/l). CONCLUSIONS: To the best of our knowledge, this is the first case report of development of MAS in a patient with preexisting AOSD after vaccination in general, and SARS-CoV-2 vaccination in particular. The new mRNA vaccines have generally shown a reassuring safety profile, but it has been shown that nucleic acids in general, including mRNA can act as pathogen-associated molecular patterns that activate toll-like receptors with extensive production of pro-inflammatory cytokines and further activation of immune cells. Proving an interferon 1 response in our patient directly after vaccination, we think that in this particular case the vaccination might have acted as trigger for the development of MAS. Even if it remains difficult to establish causality in the case of rare adverse events, especially in patients with autoimmune or autoinflammatory conditions, these complications are important to monitor and register, but do not at all diminish the overwhelming positive benefit-risk ratio of licensed COVID-19 vaccines. CI - © 2021. The Author(s). FAU - Muench, Frédéric AU - Muench F AUID- ORCID: 0000-0003-3114-0471 AD - Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. frederic.muench@charite.de. FAU - Krusche, Martin AU - Krusche M AD - Department of Rheumatology and Immunology, Charité - Universitätsmedizin, Berlin, Germany. AD - Department of Rheumatology and Systemic Inflammatory Diseases, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. FAU - Sander, Leif Erik AU - Sander LE AD - Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin, Berlin, Germany. FAU - Rose, Thomas AU - Rose T AD - Department of Rheumatology and Immunology, Charité - Universitätsmedizin, Berlin, Germany. FAU - Burmester, Gerd-Rüdiger AU - Burmester GR AD - Department of Rheumatology and Immunology, Charité - Universitätsmedizin, Berlin, Germany. FAU - Schneider, Udo AU - Schneider U AD - Department of Rheumatology and Immunology, Charité - Universitätsmedizin, Berlin, Germany. LA - eng PT - Journal Article DEP - 20211228 PL - England TA - BMC Rheumatol JT - BMC rheumatology JID - 101738571 PMC - PMC8712099 OTO - NOTNLM OT - Adult-onset Still’s disease OT - Macrophage activation syndrome OT - Vaccine reaction COIS- The authors declare that they have no competing interests. EDAT- 2021/12/29 06:00 MHDA- 2021/12/29 06:01 PMCR- 2021/12/28 CRDT- 2021/12/28 05:40 PHST- 2021/09/22 00:00 [received] PHST- 2021/10/21 00:00 [accepted] PHST- 2021/12/28 05:40 [entrez] PHST- 2021/12/29 06:00 [pubmed] PHST- 2021/12/29 06:01 [medline] PHST- 2021/12/28 00:00 [pmc-release] AID - 10.1186/s41927-021-00237-9 [pii] AID - 237 [pii] AID - 10.1186/s41927-021-00237-9 [doi] PST - epublish SO - BMC Rheumatol. 2021 Dec 28;5(1):60. doi: 10.1186/s41927-021-00237-9. PMID- 32625667 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231004 IS - 1831-4732 (Electronic) IS - 1831-4732 (Linking) VI - 16 IP - 1 DP - 2018 Jan TI - Safety assessment of the substance isobutane, for use in food contact materials. PG - e05116 LID - 10.2903/j.efsa.2018.5116 [doi] LID - e05116 AB - The substance isobutane is intended to be used as a foaming agent at max 4.5% to produce expanded polystyrene (EPS) to be used for packaging foods, such as fruits, vegetables, meat, fish and cheese, at room temperature or lower. Isobutane is approved in Europe as a food additive (E 943b) to be used quantum satis as a gas propellant only in vegetable oil pan spray (for professional use only) and water-based emulsion spray according to Regulation (EC) No 1333/2008. The purity requirements for the use of isobutane as a food additive are described in Commission Regulation (EU) No 231/2012. The substance is a gas at room temperature. It is a saturated hydrocarbon, obtained with a high level of purity, and is not expected to react under the processing conditions used to make foamed polystyrene materials and articles. Data on migration of isobutane from trays at 20°C for 10 days ranged from 0.2 to 0.4 mg/kg food. Considering the intended applications, estimated exposure is extremely low based on migration data. In the absence of genotoxicity alerts and given the very low toxicity following repeated exposure with no observed adverse effect concentration (NOAEC) of several thousands of mg/m(3) by inhalation, it was considered that the use of isobutane as a foaming agent, at the expected exposure from food, does not raise a safety concern. CI - © 2018 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. CN - EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) FAU - Silano, Vittorio AU - Silano V FAU - Bolognesi, Claudia AU - Bolognesi C FAU - Chipman, Kevin AU - Chipman K FAU - Cravedi, Jean-Pierre AU - Cravedi JP FAU - Engel, Karl-Heinz AU - Engel KH FAU - Fowler, Paul AU - Fowler P FAU - Franz, Roland AU - Franz R FAU - Grob, Konrad AU - Grob K FAU - Gürtler, Rainer AU - Gürtler R FAU - Husøy, Trine AU - Husøy T FAU - Kärenlampi, Sirpa AU - Kärenlampi S FAU - Mennes, Wim AU - Mennes W FAU - Milana, Maria Rosaria AU - Milana MR FAU - Pfaff, Karla AU - Pfaff K FAU - Riviere, Gilles AU - Riviere G FAU - Srinivasan, Jannavi AU - Srinivasan J FAU - Tavares Poças, Maria de Fátima AU - Tavares Poças MF FAU - Tlustos, Christina AU - Tlustos C FAU - Wölfle, Detlef AU - Wölfle D FAU - Zorn, Holger AU - Zorn H FAU - Kolf-Clauw, Martine AU - Kolf-Clauw M FAU - Lampi, Eugenia AU - Lampi E FAU - Svensson, Kettil AU - Svensson K FAU - Lioupis, Alexandros AU - Lioupis A FAU - Castle, Laurence AU - Castle L LA - eng PT - Journal Article DEP - 20180112 PL - United States TA - EFSA J JT - EFSA journal. European Food Safety Authority JID - 101642076 PMC - PMC7009337 OTO - NOTNLM OT - CAS No 75‐28‐5 OT - E 943b OT - FCM Substance No 1069 OT - Isobutane OT - foaming agent OT - food contact materials OT - polystyrene OT - safety assessment EDAT- 2018/01/12 00:00 MHDA- 2018/01/12 00:01 PMCR- 2018/01/12 CRDT- 2020/07/07 06:00 PHST- 2020/07/07 06:00 [entrez] PHST- 2018/01/12 00:00 [pubmed] PHST- 2018/01/12 00:01 [medline] PHST- 2018/01/12 00:00 [pmc-release] AID - EFS25116 [pii] AID - 10.2903/j.efsa.2018.5116 [doi] PST - epublish SO - EFSA J. 2018 Jan 12;16(1):e05116. doi: 10.2903/j.efsa.2018.5116. eCollection 2018 Jan. PMID- 32055692 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240328 IS - 2397-9070 (Electronic) IS - 2397-9070 (Linking) VI - 4 IP - 1 DP - 2020 Feb TI - Is complete stone removal for choledocholithiasis always necessary in extremely elderly patients? PG - 16-21 LID - 10.1002/jgh3.12198 [doi] AB - BACKGROUND AND AIM: Endoscopic stone removal has some complications. Although the life expectancy of elderly patients has increased dramatically worldwide, little information is available on the necessity of complete endoscopic stone removal in extremely elderly patients. This study aimed to evaluate the safety and efficacy of complete endoscopic stone removal in extremely elderly patients. METHODS: All extremely elderly patients (>90 years) who underwent endoscopic stone removal for choledocholithiasis at our hospital between January 2012 and January 2017 were retrospectively evaluated. The included patients were divided into complete stone removal and incomplete stone removal groups. Complication rate, overall survival (OS), and disease-specific survival (DSS) rates were compared between the two groups. RESULTS: Overall, 73 patients were included in this study. The median number of stones was one (range, 0-10) and two (range, 1-12) (P = 0.043), while the median diameter of the largest stones was 9 (range, 0-27) and 14 (range, 5-46) mm (P = 0.001) in the complete and incomplete stone removal groups, respectively. During the follow-up period, OS was 60% and 39% and DSS was 95% and 97% in the complete and incomplete stone removal groups, respectively. Kaplan-Meier analysis found no significant difference in OS and DSS between the two groups (P = 0.052 and P = 0.646, respectively). CONCLUSION: Complete stone removal might not always be necessary in extremely elderly patients aged ≥90 years. CI - © 2019 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. FAU - Okuda, Naoko AU - Okuda N AUID- ORCID: 0000-0001-6196-5912 AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Sugimoto, Shinya AU - Sugimoto S AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Nakamura, Haruka AU - Nakamura H AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Hisada, Hirohisa AU - Hisada H AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Temma, Taishi AU - Temma T AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Hashimoto, Yuki AU - Hashimoto Y AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Hayashi, Satoshi AU - Hayashi S AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Ito, Tatsuya AU - Ito T AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Takami, Mayuko AU - Takami M AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Oyamada, Jun AU - Oyamada J AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. FAU - Kamei, Akira AU - Kamei A AD - Divisions of Gastroenterology Ise Red Cross Hospital Mie Japan. LA - eng PT - Journal Article DEP - 20190530 PL - Australia TA - JGH Open JT - JGH open : an open access journal of gastroenterology and hepatology JID - 101730833 PMC - PMC7008169 OTO - NOTNLM OT - choledocholithiasis OT - extremely elderly OT - plastic stent EDAT- 2020/02/15 06:00 MHDA- 2020/02/15 06:01 PMCR- 2019/05/30 CRDT- 2020/02/15 06:00 PHST- 2019/04/07 00:00 [received] PHST- 2019/04/21 00:00 [accepted] PHST- 2020/02/15 06:00 [entrez] PHST- 2020/02/15 06:00 [pubmed] PHST- 2020/02/15 06:01 [medline] PHST- 2019/05/30 00:00 [pmc-release] AID - JGH312198 [pii] AID - 10.1002/jgh3.12198 [doi] PST - epublish SO - JGH Open. 2019 May 30;4(1):16-21. doi: 10.1002/jgh3.12198. eCollection 2020 Feb. PMID- 19715638 OWN - NLM STAT- MEDLINE DCOM- 20100106 LR - 20090831 IS - 0001-7310 (Print) IS - 0001-7310 (Linking) VI - 100 IP - 7 DP - 2009 Sep TI - [An update on scalp psoriasis]. PG - 536-43 AB - Between 50 % and 80 % of patients with psoriasis have involvement of the scalp. The clinical presentation of scalp psoriasis can be very varied, with disease severity ranging from mild to extremely severe.The disease may have a major psychological impact. Treatment should be tailored to each individual in order to achieve a good clinical response or blanching that lasts for as long as possible, with a safe and convenient regimen. Many different treatments have been tried: phototherapy, pulsed magnetic fields, Grenz rays, keratolytics, coal tar, antifungals, dithranol, retinoids, vitamin D analogues, corticosteroids, and systemic treatment. Ideally, for scalp psoriasis, treatment should be effective; applied in the form of a lotion, foam, or emulsion; require few applications per week; and have proven long-term safety. One such treatment is potent corticosteroids and vitamin D3 analogues in combination, which has a fast onset of action and proven long-term safety. FAU - Sola-Ortigosa, J AU - Sola-Ortigosa J AD - Unidad de Psoriasis y Fototerapia, Unidad Docente de la Universidad de Barcelona. Barcelona. España. 38725jso@comb.es FAU - Sánchez-Regaña, M AU - Sánchez-Regaña M FAU - Umbert-Millet, P AU - Umbert-Millet P LA - spa PT - English Abstract PT - Journal Article PT - Review TT - Psoriasis del cuero cabelludo. PL - Spain TA - Actas Dermosifiliogr JT - Actas dermo-sifiliograficas JID - 0373062 SB - IM MH - Diagnosis, Differential MH - Humans MH - *Psoriasis/diagnosis/drug therapy MH - *Scalp Dermatoses/diagnosis/drug therapy RF - 29 EDAT- 2009/09/01 06:00 MHDA- 2010/01/07 06:00 CRDT- 2009/09/01 09:00 PHST- 2009/09/01 09:00 [entrez] PHST- 2009/09/01 06:00 [pubmed] PHST- 2010/01/07 06:00 [medline] AID - S0001-7310(09)71901-5 [pii] PST - ppublish SO - Actas Dermosifiliogr. 2009 Sep;100(7):536-43. PMID- 8568909 OWN - NLM STAT- MEDLINE DCOM- 19960301 LR - 20131121 IS - 0098-4108 (Print) IS - 0098-4108 (Linking) VI - 47 IP - 1 DP - 1996 Jan TI - Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances. PG - 1-30 AB - The development of drugs to combat diseases, chemicals to improve food production, or compounds to enhance the quality of life necessitates, by law, the use of laboratory animals to test their safety. In order to simulate the human condition it is necessary to choose a species in which pharmacokinetic and toxicokinetic mechanisms are established and resemble those of humans. The advantages of the use of the rat in drug and chemical toxicity testing include (a) metabolic pathway similarities to humans; (b) numerous similar anatomical and physiological characteristics; (c) a large database, which is extremely important for comparative purposes; and (d) the ease of breeding and maintenance of animals at relatively low cost. However, the choice of rat can be complicated, especially when over 200 different strains of rat are known to exist. The aim of this review is to summarize genetically determined differences in the responsiveness of rat strains to drugs and naturally occurring chemicals and to show that susceptibility is dependent on the target organ sensitivities, which may also be strain dependent. It is suggested that detailed studies of strain differences may help to clarify toxic mechanisms. Such studies are usually best conducted using inbred strains in which the genetic characteristics have been fixed, rather than in outbred stocks in which individual samples of animals may differ, the phenotype is variable, and the stocks are subject to substantial genetic drift. The fact that strains may differ also needs to be taken into account in assessing the potential hazard of the chemical, particularly when a study involves only a single strain and therefore provides no assessment of likely strain variation. FAU - Kacew, S AU - Kacew S AD - Department of Pharmacology, University of Ottawa, Ontario, Canada. FAU - Festing, M F AU - Festing MF LA - eng PT - Journal Article PT - Review PL - United States TA - J Toxicol Environ Health JT - Journal of toxicology and environmental health JID - 7513622 SB - IM MH - Animals MH - Animals, Genetically Modified/genetics/metabolism MH - Disease Susceptibility MH - Drug Resistance MH - *Drug-Related Side Effects and Adverse Reactions MH - Genotype MH - Humans MH - Kidney/drug effects/metabolism MH - Liver/drug effects/metabolism MH - Lung/drug effects MH - Nervous System/drug effects MH - Rats MH - Rats, Inbred Strains/*genetics/immunology/metabolism MH - Rats, Mutant Strains/*genetics/metabolism MH - Species Specificity MH - Tissue Distribution MH - Viscera/drug effects RF - 145 EDAT- 1996/01/01 00:00 MHDA- 1996/01/01 00:01 CRDT- 1996/01/01 00:00 PHST- 1996/01/01 00:00 [pubmed] PHST- 1996/01/01 00:01 [medline] PHST- 1996/01/01 00:00 [entrez] AID - 10.1080/009841096161960-2840 [doi] PST - ppublish SO - J Toxicol Environ Health. 1996 Jan;47(1):1-30. doi: 10.1080/009841096161960-2840. PMID- 22185188 OWN - NLM STAT- MEDLINE DCOM- 20120509 LR - 20211021 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 9 DP - 2011 Dec 20 TI - The king is dead, long live the king: entering a new era of stem cell research and clinical development. PG - 218 LID - 10.1186/1479-5876-9-218 [doi] AB - In mid November the biopharma industry was shocked by the announcement from Geron that they were ending work on embryonic stem cell research and therapy. For more than 10 years the public image of all stem cell research has been equated with embryonic stem cells. Unfortunately, a fundamentally important medical and financial fact was being ignored: embryonic stem cell therapy is extremely immature. In parallel to efforts in embryonic stem cell research and development, scientists and physicians in the field of adult stem cells realized that the natural role of adult stem cells in the body is to promote healing and to act like endogenous "repair cells" and, as a result, numerous companies have entered the field of adult stem cell therapy with the goal of expanding numbers of adult stem cells for administration to patients with various conditions. In contrast to embryonic stem cells, which are extremely expensive and potentially dangerous, adult cell cells are inexpensive and have an excellent safety record when used in humans. Many studies are now showing that adult stem cells are practical, patient-applicable, therapeutics that are very close to being available for incorporation into the practice of medicine. These events signal the entrance of the field of stem cells into a new era: an era where hype and misinformation no longer triumph over economic and medical realities. FAU - Ichim, Thomas AU - Ichim T FAU - Riordan, Neil H AU - Riordan NH FAU - Stroncek, David F AU - Stroncek DF LA - eng PT - Editorial DEP - 20111220 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM CIN - J Transl Med. 2012 Mar 26;10:60. doi: 10.1186/1479-5876-10-60. PMID: 22448812 MH - Adult Stem Cells/cytology MH - Animals MH - Clinical Trials as Topic MH - Drug Industry/economics MH - Embryonic Stem Cells/cytology MH - Humans MH - *Stem Cell Research/economics/ethics MH - Universities PMC - PMC3275507 EDAT- 2011/12/22 06:00 MHDA- 2012/05/10 06:00 PMCR- 2011/12/20 CRDT- 2011/12/22 06:00 PHST- 2011/12/13 00:00 [received] PHST- 2011/12/20 00:00 [accepted] PHST- 2011/12/22 06:00 [entrez] PHST- 2011/12/22 06:00 [pubmed] PHST- 2012/05/10 06:00 [medline] PHST- 2011/12/20 00:00 [pmc-release] AID - 1479-5876-9-218 [pii] AID - 10.1186/1479-5876-9-218 [doi] PST - epublish SO - J Transl Med. 2011 Dec 20;9:218. doi: 10.1186/1479-5876-9-218. PMID- 20640111 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20110714 LR - 20231105 IS - 0976-2817 (Electronic) IS - 0019-5049 (Print) IS - 0019-5049 (Linking) VI - 53 IP - 5 DP - 2009 Oct TI - Current status of obstetric anaesthesia: improving satisfaction and safety. PG - 608-17 AB - The Centers for Disease Control and Prevention (CDC) reported in 2003 that although the maternal mortality rate has decreased by 99% since 1900, there has been no further decrease in the last two decades1. A more recent report indicates a rate of 11.8 per 100,000 live births2, although anaesthesia-related maternal mortality and morbidity has considerably decreased over the last few decades. Despite the growing complexity of problems and increasing challenges such as pre-existing maternal disease, obesity, and the increasing age of pregnant mothers, anaesthesia related maternal mortality is extremely rare in the developed world. The current safety has been achieved through changes in training, service, technical advances and multidisciplinary approach to care. The rates of general anaesthesia for cesarean delivery have decreased and neuraxial anaesthetics have become the most commonly used techniques. Neuraxial techniques are largely safe and effective, but potential complications, though rare, can be severe. FAU - Ranasinghe, J Sudharma AU - Ranasinghe JS AD - Professor, Department of Anesthesiology, Obstetric and Gynaecology and Public Health, University of Miami Miller School of Medicine. FAU - Birnbach, David AU - Birnbach D LA - eng PT - Journal Article PL - India TA - Indian J Anaesth JT - Indian journal of anaesthesia JID - 0013243 PMC - PMC2900093 OTO - NOTNLM OT - Combined Spinal Epidural (CSE) OT - Hypotension OT - Maternal mortality OT - Obesity OT - Obstetric Anesthesia OT - Preeclampsia EDAT- 2010/07/20 06:00 MHDA- 2010/07/20 06:01 PMCR- 2009/10/01 CRDT- 2010/07/20 06:00 PHST- 2010/07/20 06:00 [entrez] PHST- 2010/07/20 06:00 [pubmed] PHST- 2010/07/20 06:01 [medline] PHST- 2009/10/01 00:00 [pmc-release] AID - IJA-53-608 [pii] PST - ppublish SO - Indian J Anaesth. 2009 Oct;53(5):608-17. PMID- 34032775 OWN - NLM STAT- MEDLINE DCOM- 20210730 LR - 20230103 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 100 IP - 21 DP - 2021 May 28 TI - Protective and therapeutic experience of perioperative safety in extremely elderly patients with biliary diseases. PG - e26159 LID - 10.1097/MD.0000000000026159 [doi] LID - e26159 AB - To explore the protective and therapeutic measures of improving perioperative safety in extremely elderly patients with biliary diseases, so as to improve the therapeutic efficacy of surgery. A retrospective case–control study of 412 elderly patients with biliary diseases was carried out from July 2013 to July 2019. Seventy eight cases were divided into the high age (HA) group (≥80 years) and 334 into the middle–low age (MLA) group (60–79 years). In the HA compared with MLA group, 1. Preoperative coexisting diseases: the occurrence of coexisting coronary heart disease (CHD), hypertension, chronic bronchitis with emphysema, hypoproteinemia, and anemia were significantly increased; 2. Laboratory examinations: function of liver, kidneys, heart, lungs, and blood coagulation significantly declined; 3. Surgical procedures: open cholecystectomy with transcystic common bile duct (CBD) exploration significantly higher, while laparoscopic cholecystectomy significantly lower; 4. Operative effects: intraoperative blood loss, operation time, postoperative hospital stay, and length of hospitalization significantly increased or prolonged; 5. Postoperative complications: postoperative respiratory failure, pulmonary infection, anemia and electrolyte disorder significantly increased; 6. Therapeutic outcomes: no significant difference in the therapeutic effects. Although the surgical risk was significantly increased, there was no significant difference in the therapeutic efficacy in the HA compared with MLA group, suggesting that surgical treatment in extremely elderly patients with biliary diseases is safe and feasible. The key is to actively treat preoperative coexisting diseases, strictly adhere to surgical indications, reasonably select surgical procedures, precisely perform the operation, closely monitor and control intraoperative emergencies, timely prevent and treat postoperative complications, so as to improve the perioperative safety of extremely elderly patients with biliary diseases. FAU - Zhang, Zongming AU - Zhang Z AD - Department of General Surgery, Beijing Electric Power Hospital, State Grid Corporation of China, Capital Medical University, Beijing, PR China. FAU - Zhao, Yue AU - Zhao Y FAU - Lin, Fangcai AU - Lin F FAU - Liu, Limin AU - Liu L FAU - Zhang, Chong AU - Zhang C FAU - Liu, Zhuo AU - Liu Z FAU - Zhu, Mingwen AU - Zhu M FAU - Wan, Baijiang AU - Wan B FAU - Deng, Hai AU - Deng H FAU - Yang, Haiyan AU - Yang H FAU - Jiao, Lijun AU - Jiao L FAU - Xie, Xiyuan AU - Xie X LA - eng GR - No. Z171100000417056/Beijing Municipal Science & Technology Commission/ GR - No. SGHB0000AJJS1400182/Science and Technology Project of State Grid (CN)/ PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Biliary Tract Diseases/blood/epidemiology/*surgery MH - China/epidemiology MH - Comorbidity MH - Humans MH - Middle Aged MH - Perioperative Care/*statistics & numerical data MH - Postoperative Complications/*epidemiology MH - Retrospective Studies PMC - PMC8154467 COIS- The authors have no conflicts of interests to disclose. EDAT- 2021/05/26 06:00 MHDA- 2021/07/31 06:00 PMCR- 2021/05/28 CRDT- 2021/05/25 13:55 PHST- 2020/02/21 00:00 [received] PHST- 2021/05/06 00:00 [accepted] PHST- 2021/05/25 13:55 [entrez] PHST- 2021/05/26 06:00 [pubmed] PHST- 2021/07/31 06:00 [medline] PHST- 2021/05/28 00:00 [pmc-release] AID - 00005792-202105280-00085 [pii] AID - MD-D-20-01515 [pii] AID - 10.1097/MD.0000000000026159 [doi] PST - ppublish SO - Medicine (Baltimore). 2021 May 28;100(21):e26159. doi: 10.1097/MD.0000000000026159. PMID- 36459809 OWN - NLM STAT- MEDLINE DCOM- 20221207 LR - 20221225 IS - 1879-0534 (Electronic) IS - 0010-4825 (Linking) VI - 151 IP - Pt B DP - 2022 Dec TI - A 7-segment numerical hand-glove/mitten model for predicting thermophysiological responses of the human hand in extremely cold conditions. PG - 106351 LID - S0010-4825(22)01059-9 [pii] LID - 10.1016/j.compbiomed.2022.106351 [doi] AB - A 7-segment and 29-node numerical hand-glove/mitten model was developed to simulate human hand physiological responses in various cold environments. To validate the model, simulated skin temperatures were compared to data from published literature and human trials conducted at -20, -40, and -60 °C. Results demonstrated that the model could reasonably predict cold-induced vasodilation (CIVD) responses at 0 °C temperature. At -20 °C, the model predicted skin temperature with the root mean square deviation (RMSD) falling within the measurement standard deviation (SD) for both the entire and local hand except for the posterior hand. At -40 and -60 °C, the model could predict the trend of the skin temperatures of the whole/local hand, but the RMSD was larger than the SD for the majority of predictions. A parametric analysis revealed that the palm and posterior hand had higher skin temperatures than the fingers, while the thumb had the lowest skin temperature of the fingers in all simulated cases except the case with a 3.5 clo mitten at -60 °C. The proposed numerical hand-glove/mitten model could reasonably predict local hand physiological responses in three extremely cold environments and provides fundamental knowledge for cold stress prediction and protective glove development, thereby improving the safety and health of industrial workers, firefighters, first responders, and troops. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Yang, Jie AU - Yang J AD - College of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China. FAU - Wang, Faming AU - Wang F AD - Division Animal and Human Health Engineering, Department of Biosystems (BIOSYST), KU Leuven, Kasteelpark Arenberg 30, BE-3001, Leuven, Belgium. Electronic address: faming.wang@kuleuven.be. FAU - White, Matthew David AU - White MD AD - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. FAU - Li, Rui AU - Li R AD - College of Human Sciences, Iowa State University, Ames, IA, 50010, USA. FAU - Song, Guowen AU - Song G AD - College of Human Sciences, Iowa State University, Ames, IA, 50010, USA. FAU - Etter, Clara V AU - Etter CV AD - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. FAU - Gnatiuk, Elizabeth A AU - Gnatiuk EA AD - Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. FAU - Perrotta, Andrew S AU - Perrotta AS AD - Department of Kinesiology, University of Windsor, Ontario, N9B 3P4, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221126 PL - United States TA - Comput Biol Med JT - Computers in biology and medicine JID - 1250250 SB - IM MH - Humans MH - *Skin Temperature MH - *Cold Temperature MH - Hand/physiology MH - Gloves, Protective MH - Fingers/physiology MH - Vasodilation/physiology OTO - NOTNLM OT - Cold environment OT - Cold injury OT - Cold-induced vasodilation OT - Gloves OT - Hand OT - Thermophysiological response COIS- Declaration of competing interest The work described has not been submitted elsewhere for publication, in whole or in part, and all the authors listed have approved the manuscript that is enclosed. EDAT- 2022/12/03 06:00 MHDA- 2022/12/27 06:00 CRDT- 2022/12/02 18:18 PHST- 2022/08/23 00:00 [received] PHST- 2022/11/03 00:00 [revised] PHST- 2022/11/23 00:00 [accepted] PHST- 2022/12/03 06:00 [pubmed] PHST- 2022/12/27 06:00 [medline] PHST- 2022/12/02 18:18 [entrez] AID - S0010-4825(22)01059-9 [pii] AID - 10.1016/j.compbiomed.2022.106351 [doi] PST - ppublish SO - Comput Biol Med. 2022 Dec;151(Pt B):106351. doi: 10.1016/j.compbiomed.2022.106351. Epub 2022 Nov 26. PMID- 20813274 OWN - NLM STAT- MEDLINE DCOM- 20110125 LR - 20100903 IS - 1557-9840 (Electronic) IS - 0095-5108 (Linking) VI - 37 IP - 3 DP - 2010 Sep TI - Strategies to prevent invasive candidal infection in extremely preterm infants. PG - 611-28 LID - 10.1016/j.clp.2010.06.003 [doi] AB - The highest incidence of invasive candidal infection (ICI) occurs in extremely preterm infants (<1000 g birth weight and 1400 nmol/l for the newborns treated with hydrocortisone. Initial serum cortisol level was measured in the umbilical blood or immediately after admission to the NICU. Cortisol level was determined by LIA method using Liason apparatus, and the results were presented in nmol/l. If hypotension was diagnosed (mean arterial blood pressure value <10 percentile for gestational age in mmHg), 0.9% NaCl was used and catecholamines (dopamine and dobutrex)were administered. If the hypotension was not responding to treatment hydrocortisone was administered. During hospitalization echocardiography and cranial ultrasound examinations were performed, assessing main complications: IVH, PVL, SIP, NEC and hyperglycemia (blood glucose concentration >200 mg%). STATISTIC ANALYSIS: Calculations were made with the SPSS v 12.01 statistical software. Chi(2) test, Mann-Whitney and Spearman tests were used. Significance level of alpha <0.05 was applied. RESULTS: A wide dispersion of serum cortisol levels was observed (58.5-3766.5 nmol/l: median - 293.8 nmol/l) and no correlation was found between the gestational age and cortisol level and the incidence of hypotension. Ten infants required hydrocortisone administration (29%). In the tested group intestine perforation was diagnosed in 6 infants (17%). In both groups hyperglycaemia was found in 50% cases. No case of PVL was diagnosed in the studied group. Statistically significant difference was noted regarding IVH grade III and IV. Their incidence was higher in the group with hypotension (48%) as compared to the non treated group (10%). CONCLUSIONS: 1. The dispersion of serum cortisol levels in the first 72 hours in very preterm newborns is wide. No correlation was found between cortisol level and gestational age and the incidence of hypotension in the studied population. 2. In hydrocortisone-treated group no complications such as SIP and PVL were found. The incidence of hyperglycemia was the same as in the untreated group, which may indicate that the treatment is safe. The results need to be confirmed on a larger number of patients. 3. It was confirmed that hypotension is a significant risk factor for IVH. 4. The study needs to be continued in order to increase the population of newborns treated with hydrocortisone. Their long term follow-up will make it possible to assess the safety of this treatment. FAU - Rutkowska, Magdalena AU - Rutkowska M AD - Klinika Neonatologii i Intensywnej Terapii Noworodka, Instytut Matki i Dziecka, 01-211 Warszawa. magda_rutkowska@poczta.onet.pl FAU - Resko-Zachara, Marzena AU - Resko-Zachara M FAU - Adamska, Ewa AU - Adamska E FAU - Ołtarzewski, Mariusz AU - Ołtarzewski M FAU - Szamotulska, Katarzyna AU - Szamotulska K LA - pol PT - English Abstract PT - Journal Article TT - Stezenie kortyzolu w pierwszych dobach zycia a hipotensja i leczenie niewydolności krazenia u noworodków skrajnie niedojrzałych - doniesienie wstepne. PL - Poland TA - Med Wieku Rozwoj JT - Medycyna wieku rozwojowego JID - 100928610 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Cerebrovascular Disorders/blood/diagnosis/*epidemiology/*therapy MH - Comorbidity MH - Enterocolitis/epidemiology MH - Female MH - Gestational Age MH - Humans MH - Hydrocortisone/*blood/therapeutic use MH - Hyperglycemia/epidemiology MH - Hypertension/epidemiology MH - Hypotension/drug therapy/*epidemiology MH - Incidence MH - Infant MH - Infant, Newborn MH - Infant, Premature, Diseases/blood/diagnosis/*epidemiology/*therapy MH - Male MH - Poland/epidemiology MH - Risk Factors MH - Survival Rate EDAT- 2008/01/01 00:00 MHDA- 2009/07/31 09:00 CRDT- 2009/05/28 09:00 PHST- 2009/05/28 09:00 [entrez] PHST- 2008/01/01 00:00 [pubmed] PHST- 2009/07/31 09:00 [medline] PST - ppublish SO - Med Wieku Rozwoj. 2008 Oct-Dec;12(4 Pt 1):950-7. PMID- 39886043 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250204 IS - 2214-7500 (Electronic) IS - 2214-7500 (Linking) VI - 14 DP - 2025 Jun TI - Toxic natural pollution at Ijen crater volcano: Environmental characteristics and health risk assessment. PG - 101899 LID - 10.1016/j.toxrep.2025.101899 [doi] LID - 101899 AB - The Ijen crater volcano (ICV) is one of the active volcanoes with unique environmental conditions; it is the largest lake in the world with the most extreme acidity and a blue fire phenomenon and releases toxic volcanic gases, including dangerous sulfur dioxide (SO₂). It has an impact on the environment and ecosystem. This research aimed to investigate the blue fire phenomena and toxic gas SO(2) and characterize the environmental conditions and health effects of the ICV. The method used in this research involved carrying out an SO(2) concentration using an impinger in 32-point sampling around the Inje crater volcano. The environment was characterized based on self-observation, station observation, interviews, and reliable literature data. The health effect was measured based on the threshold level value based on local and global regulations. This research shows that the characteristics of the ICV include a crater lake with a depth of up to 200 m and a diameter of ± 900 m with pH values less than 1. Then, the source of SO(2) comes from the reaction of magma with volcanic gas. the blue fire phenomenon, which occurs in certain situations, frequently adds to the natural wonder of the ICV. In addition, the distribution of SO(2) concentrations ranges from 480 to 6960 ppb. Next, almost the Hazard Quotion (HQ) > 1 every point sampling. This means that the SO(2) concentration and HQ exceed the threshold value affecting human activities. CI - © 2025 The Authors. FAU - Susetyo, Septian Hadi AU - Susetyo SH AD - Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan. AD - Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung (ITB), Bandung 40132, Indonesia. FAU - Abidin, Azham Umar AU - Abidin AU AD - Department of Environmental Engineering, Faculty of Civil Engineering and Planning, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia. FAU - Sano, Kyosuke AU - Sano K AD - Laboratory of Safety and Occupational Health Engineering (Agency for Health, Safety and Environment), Kyoto University, Kyoto 606-8501, Japan. FAU - Yoneda, Minoru AU - Yoneda M AD - Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan. FAU - Matsui, Yasuto AU - Matsui Y AD - Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 606-8501, Japan. LA - eng PT - Journal Article DEP - 20250105 PL - Ireland TA - Toxicol Rep JT - Toxicology reports JID - 101630272 PMC - PMC11780170 OTO - NOTNLM OT - Blue fire phenomena OT - Environmental characteristics OT - Health risk assessment OT - Ijen crater volcano OT - Natural pollution OT - SO2 distribution COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/01/31 06:17 MHDA- 2025/01/31 06:18 PMCR- 2025/01/05 CRDT- 2025/01/31 04:28 PHST- 2024/11/25 00:00 [received] PHST- 2025/01/02 00:00 [revised] PHST- 2025/01/03 00:00 [accepted] PHST- 2025/01/31 06:18 [medline] PHST- 2025/01/31 06:17 [pubmed] PHST- 2025/01/31 04:28 [entrez] PHST- 2025/01/05 00:00 [pmc-release] AID - S2214-7500(25)00017-4 [pii] AID - 101899 [pii] AID - 10.1016/j.toxrep.2025.101899 [doi] PST - epublish SO - Toxicol Rep. 2025 Jan 5;14:101899. doi: 10.1016/j.toxrep.2025.101899. eCollection 2025 Jun. PMID- 22973193 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20211021 IS - 1662-5102 (Electronic) IS - 1662-5102 (Linking) VI - 6 DP - 2012 TI - Implications of aneuploidy for stem cell biology and brain therapeutics. PG - 36 LID - 10.3389/fncel.2012.00036 [doi] LID - 36 AB - Understanding the cellular basis of neurological disorders have advanced at a slow pace, especially due to the extreme invasiveness of brain biopsying and limitations of cell lines and animal models that have been used. Since the derivation of pluripotent stem cells (PSCs), a novel source of cells for regenerative medicine and disease modeling has become available, holding great potential for the neurology field. However, safety for therapy and accurateness for modeling have been a matter of intense debate, considering that genomic instability, including the gain and loss of chromosomes (aneuploidy), has been repeatedly observed in those cells. Despite the fact that recent reports have described some degree of aneuploidy as being normal during neuronal differentiation and present in healthy human brains, this phenomenon is particularly controversial since it has traditionally been associated with cancer and disabling syndromes. It is therefore necessary to appreciate, to which extent, aneuploid pluripotent stem cells are suitable for regenerative medicine and neurological modeling and also the limits that separate constitutive from disease-related aneuploidy. In this review, recent findings regarding chromosomal instability in PSCs and within the brain will be discussed. FAU - Devalle, Sylvie AU - Devalle S AD - National Laboratory for Embryonic Stem Cells, Institute of Biomedical Sciences, Federal University of Rio de Janeiro Rio de Janeiro, RJ, Brazil. FAU - Sartore, Rafaela C AU - Sartore RC FAU - Paulsen, Bruna S AU - Paulsen BS FAU - Borges, Helena L AU - Borges HL FAU - Martins, Rodrigo A P AU - Martins RA FAU - Rehen, Stevens K AU - Rehen SK LA - eng PT - Journal Article DEP - 20120905 PL - Switzerland TA - Front Cell Neurosci JT - Frontiers in cellular neuroscience JID - 101477935 PMC - PMC3433681 OTO - NOTNLM OT - CNS OT - chromosomal instability OT - disease modeling OT - mosaicism OT - transplantation EDAT- 2012/09/14 06:00 MHDA- 2012/09/14 06:01 PMCR- 2012/01/01 CRDT- 2012/09/14 06:00 PHST- 2012/06/21 00:00 [received] PHST- 2012/08/18 00:00 [accepted] PHST- 2012/09/14 06:00 [entrez] PHST- 2012/09/14 06:00 [pubmed] PHST- 2012/09/14 06:01 [medline] PHST- 2012/01/01 00:00 [pmc-release] AID - 10.3389/fncel.2012.00036 [doi] PST - epublish SO - Front Cell Neurosci. 2012 Sep 5;6:36. doi: 10.3389/fncel.2012.00036. eCollection 2012. PMID- 25989203 OWN - NLM STAT- MEDLINE DCOM- 20160211 LR - 20150527 IS - 1521-3773 (Electronic) IS - 1433-7851 (Linking) VI - 54 IP - 23 DP - 2015 Jun 1 TI - Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients. PG - 6688-728 LID - 10.1002/anie.201409318 [doi] AB - In the past few years, continuous-flow reactors with channel dimensions in the micro- or millimeter region have found widespread application in organic synthesis. The characteristic properties of these reactors are their exceptionally fast heat and mass transfer. In microstructured devices of this type, virtually instantaneous mixing can be achieved for all but the fastest reactions. Similarly, the accumulation of heat, formation of hot spots, and dangers of thermal runaways can be prevented. As a result of the small reactor volumes, the overall safety of the process is significantly improved, even when harsh reaction conditions are used. Thus, microreactor technology offers a unique way to perform ultrafast, exothermic reactions, and allows the execution of reactions which proceed via highly unstable or even explosive intermediates. This Review discusses recent literature examples of continuous-flow organic synthesis where hazardous reactions or extreme process windows have been employed, with a focus on applications of relevance to the preparation of pharmaceuticals. CI - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Gutmann, Bernhard AU - Gutmann B AD - Institute of Chemistry, University Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz (Austria) http://www.maos.net. FAU - Cantillo, David AU - Cantillo D AD - Institute of Chemistry, University Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz (Austria) http://www.maos.net. FAU - Kappe, C Oliver AU - Kappe CO AD - Institute of Chemistry, University Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz (Austria) http://www.maos.net. oliver.kappe@uni-graz.at. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20150518 PL - Germany TA - Angew Chem Int Ed Engl JT - Angewandte Chemie (International ed. in English) JID - 0370543 RN - 0 (Pharmaceutical Preparations) SB - IM MH - *Chemistry, Pharmaceutical MH - *Microfluidic Analytical Techniques MH - Pharmaceutical Preparations/*chemistry MH - *Technology, Pharmaceutical OTO - NOTNLM OT - flash chemistry OT - flow chemistry OT - microreactors OT - pharmaceuticals OT - scale-up EDAT- 2015/05/20 06:00 MHDA- 2016/02/13 06:00 CRDT- 2015/05/20 06:00 PHST- 2014/09/21 00:00 [received] PHST- 2015/05/20 06:00 [entrez] PHST- 2015/05/20 06:00 [pubmed] PHST- 2016/02/13 06:00 [medline] AID - 10.1002/anie.201409318 [doi] PST - ppublish SO - Angew Chem Int Ed Engl. 2015 Jun 1;54(23):6688-728. doi: 10.1002/anie.201409318. Epub 2015 May 18. PMID- 24955860 OWN - NLM STAT- MEDLINE DCOM- 20141118 LR - 20181202 IS - 1744-7593 (Electronic) IS - 1742-5247 (Linking) VI - 11 IP - 10 DP - 2014 Oct TI - Bacteriophages as vehicles for gene delivery into mammalian cells: prospects and problems. PG - 1561-74 LID - 10.1517/17425247.2014.927437 [doi] AB - INTRODUCTION: The identification of more efficient gene delivery vehicles (GDVs) is essential to fulfill the expectations of clinical gene therapy. Bacteriophages, due to their excellent safety profile, extreme stability under a variety of harsh environmental conditions and the capability for being genetically manipulated, have drawn a flurry of interest to be applied as a newly arisen category of gene delivery platforms. AREAS COVERED: The incessant evolutionary interaction of bacteriophages with human cells has turned them into a part of our body's natural ecosystem. However, these carriers represent several barriers to gene transduction of mammalian cells. The lack of evolvement of specialized machinery for targeted cellular internalization, endosomal, lysosomal and proteasomal escape, cytoplasmic entry, nuclear localization and intranuclear transcription poses major challenges to the expression of the phage-carried gene. In this review, we describe pros and cons of bacteriophages as GDVs, provide an insight into numerous barriers that bacteriophages face for entry into and subsequent trafficking inside mammalian cells and elaborate on the strategies used to bypass these barriers. EXPERT OPINION: Tremendous genetic flexibility of bacteriophages to undergo numerous surface modifications through phage display technology has proven to be a turning point in the uncompromising efforts to surmount the limitations of phage-mediated gene expression. The revelatory outcomes of the studies undertaken within the recent years have been promising for phage-mediated gene delivery to move from concept to reality. FAU - Bakhshinejad, Babak AU - Bakhshinejad B AD - Tarbiat Modares University, Department of Genetics, Faculty of Biological Sciences , Tehran , Iran. FAU - Sadeghizadeh, Majid AU - Sadeghizadeh M LA - eng PT - Journal Article PT - Review DEP - 20140623 PL - England TA - Expert Opin Drug Deliv JT - Expert opinion on drug delivery JID - 101228421 SB - IM MH - Animals MH - Bacteriophages/*genetics MH - Gene Expression MH - Gene Transfer Techniques MH - Genetic Therapy/*methods MH - *Genetic Vectors MH - Humans OTO - NOTNLM OT - bacteriophage OT - gene delivery OT - gene therapy OT - intracellular barriers OT - phage display OT - targeting EDAT- 2014/06/24 06:00 MHDA- 2014/11/19 06:00 CRDT- 2014/06/24 06:00 PHST- 2014/06/24 06:00 [entrez] PHST- 2014/06/24 06:00 [pubmed] PHST- 2014/11/19 06:00 [medline] AID - 10.1517/17425247.2014.927437 [doi] PST - ppublish SO - Expert Opin Drug Deliv. 2014 Oct;11(10):1561-74. doi: 10.1517/17425247.2014.927437. Epub 2014 Jun 23. PMID- 16126609 OWN - NLM STAT- MEDLINE DCOM- 20060103 LR - 20221207 IS - 1067-3229 (Print) IS - 1067-3229 (Linking) VI - 13 IP - 4 DP - 2005 Jul-Aug TI - When mothers leave their children behind. PG - 233-43 AB - Psychiatry has studied the effect on children of separation from their mothers or primary caregivers, but has not given equal attention to the effect on mothers of separation from their children. This article examines the current literature on separation from the mother's perspective. Following a review of the literature on mothers' attachment behaviors, as evidenced by separation from their very young children due to ordinary circumstances, attention will turn to specific populations of mothers enduring separation from their children in situations of hardship: mothers with mental illness, homeless mothers, mothers in prison, and two groups of working mothers-immigrant mothers and deployed navy mothers. Separation can be experienced as temporary, bringing on anxiety, or may involve a mother's choice between her child's safety and her own wish to keep the child near her, causing a conflict in the mother's feelings. In other situations, separation may be involuntary and long-lasting, inducing symptoms of depression, despair, and grief, all of which are characteristic of loss. The particular conditions of the separation-such as choice, control, and ongoing communication between mother and child-can mitigate the impact of the separation and transform it from a total to a partial loss. Three clinical cases of mothers forced to separate from their children in extreme circumstances are examined, with recommendations for treatment. FAU - Schen, Cathy R AU - Schen CR AD - Department of Psychiatry, Harvard Medical School; Cambridge Health Alliance, Cambridge, MA 02139, USA. cschen@hms.harvard.edu LA - eng PT - Journal Article PL - United States TA - Harv Rev Psychiatry JT - Harvard review of psychiatry JID - 9312789 SB - IM MH - Anxiety, Separation/psychology MH - Child MH - Child, Preschool MH - Female MH - Grief MH - Ill-Housed Persons/psychology MH - Humans MH - Infant MH - *Mother-Child Relations MH - Mothers/*psychology MH - *Object Attachment MH - Prisoners/psychology MH - Psychotic Disorders/*psychology MH - Warfare MH - Women, Working/psychology EDAT- 2005/08/30 09:00 MHDA- 2006/01/04 09:00 CRDT- 2005/08/30 09:00 PHST- 2005/08/30 09:00 [pubmed] PHST- 2006/01/04 09:00 [medline] PHST- 2005/08/30 09:00 [entrez] AID - P26442683144Q170 [pii] AID - 10.1080/10673220500243380 [doi] PST - ppublish SO - Harv Rev Psychiatry. 2005 Jul-Aug;13(4):233-43. doi: 10.1080/10673220500243380. PMID- 31129893 OWN - NLM STAT- MEDLINE DCOM- 20200710 LR - 20200710 IS - 1614-7499 (Electronic) IS - 0944-1344 (Linking) VI - 27 IP - 15 DP - 2020 May TI - Effects of rainfall intensity, slope angle, and vegetation coverage on the erosion characteristics of Pisha sandstone slopes under simulated rainfall conditions. PG - 17458-17467 LID - 10.1007/s11356-019-05348-y [doi] AB - The water loss and soil erosion in the Pisha sandstone region in the middle reaches of the Yellow River are extremely severe, leading to extremely harmful effects on the ecological environment and safety of the lower reaches. In this paper, the effects of the slope angle (20, 30, and 40°), rainfall intensity (20, 50, and 80 mm/h), and vegetation coverage (10, 30, and 50%) on the erosion characteristics of the Pisha sandstone slopes are studied using indoor-simulated rainfall tests. The results show that the infiltration into the Pisha sandstone is only 10~15%. It is found that rainfall intensity has the most significant effect on runoff, which gradually increases with increasing rainfall intensity. Vegetation significantly affects runoff reduction when the rainfall intensity is low (approximately 20 mm/h), but this effect decreases with increasing rainfall intensity. Rainfall intensity has an extremely significant effect (P < 0.01) on the sediment yield, followed by vegetation coverage, and slope angle. When the vegetation coverage is approximately 50%, the reduction in sediment yield reaches approximately 70%. Additionally, the sediment reduction benefit is more significant than the runoff reduction benefit. The presence of the eroded gullies on slopes with vegetation is less compared to that on the bare slopes. Therefore, relatively high vegetation coverage (≥ 50%) is required for soil and water conservation in Pisha sandstone area. The findings will provide some reference for Pisha sandstone conservation. FAU - Liang, Zhishui AU - Liang Z AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. AD - National and Local Unified Engineering Research Center for Basalt Fiber Production and Application Technology, International Institute for Urban Systems Engineering, Southeast University, Nanjing, 211189, China. FAU - Liu, Haowei AU - Liu H AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. FAU - Zhao, Yanbing AU - Zhao Y AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. FAU - Wang, Qidong AU - Wang Q AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. FAU - Wu, Zhiren AU - Wu Z AD - School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, 212013, China. FAU - Deng, Lin AU - Deng L AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. FAU - Gao, Haiying AU - Gao H AD - School of Civil Engineering, Southeast University, No. 2 Dongnandaxue Road, Jiangning Development Zone, Nanjing, Jiangsu, China. gaohaiying@seu.edu.cn. LA - eng GR - 2017YFC0504505/National Key R&D Program of China/ GR - BK20151401/Natural Science Foundation of Jiangsu Province/ GR - 41877079/Natural Science Foundation of Jilin Province (CN)/ GR - None/The Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20190525 PL - Germany TA - Environ Sci Pollut Res Int JT - Environmental science and pollution research international JID - 9441769 RN - 0 (Soil) RN - 059QF0KO0R (Water) SB - IM MH - China MH - Conservation of Natural Resources MH - *Geologic Sediments MH - *Rain MH - Soil MH - Water MH - Water Movements OTO - NOTNLM OT - Rainfall intensity OT - Runoff OT - Sediment yield OT - Simulated rainfall OT - Slope angle OT - Vegetation coverage EDAT- 2019/05/28 06:00 MHDA- 2020/07/11 06:00 CRDT- 2019/05/27 06:00 PHST- 2019/01/06 00:00 [received] PHST- 2019/05/01 00:00 [accepted] PHST- 2019/05/28 06:00 [pubmed] PHST- 2020/07/11 06:00 [medline] PHST- 2019/05/27 06:00 [entrez] AID - 10.1007/s11356-019-05348-y [pii] AID - 10.1007/s11356-019-05348-y [doi] PST - ppublish SO - Environ Sci Pollut Res Int. 2020 May;27(15):17458-17467. doi: 10.1007/s11356-019-05348-y. Epub 2019 May 25. PMID- 27586110 OWN - NLM STAT- MEDLINE DCOM- 20170707 LR - 20191210 IS - 1538-957X (Electronic) IS - 1538-9588 (Linking) VI - 17 Suppl 1 DP - 2016 Sep TI - Quantitative evaluation of the occupant kinematic response of the THUMS 50th-percentile male model relative to PMHS laboratory rollover tests. PG - 101-8 LID - 10.1080/15389588.2016.1192282 [doi] AB - OBJECTIVE: The objective of the current study was to evaluate the whole-body kinematic response of the Total Human Model for Safety (THUMS) occupant model in controlled laboratory rollover tests by comparing the model response to postmortem human surrogate (PMHS) kinematic response targets published in 2014. METHODS: A computational model of the parametric vehicle buck environment was developed and the AM50 THUMS occupant model (Ver 4.01) was subjected to a pure dynamic roll at 360°/s in trailing-side front-row seating position. A baseline configuration was defined by a baseline posture representing the average of all PMHS postures, with a friction coefficient of 0.4 for the belt and 0.6 for the seat. To encompass challenges in controlling boundary conditions from the PMHS tests and ensure the robustness of the model evaluation, a total of 12 simulations were performed to investigate the following: 1. The effect of initial posture by adding 3 additional postures representing PMHS extremes. 2. The effect of belt tension by varying tension from the nominal vehicle retractor belt tension of 5 N to the 35 N belt tension used in the PMHS tests. 3. The effect of friction between the environment (belt, seat) and THUMS. Trajectories (head, T1, T4, T10, L1, and sacrum), spinal segment rotations (head-to-T1, T1-to-T4, T4-to-T10, T10-to-L1, and L1-to-sacrum) relative to the rollover buck and spinal segment elongation/compression calculated from the simulations were compared to PMHS corridors using a correlation method (CORA). RESULTS: THUMS baseline response showed lower correlation (overall CORA score = 0.63) with the PMHS response in rollover compared to other crash modes. THUMS and PMHS demonstrated similar kinematic responses in the longitudinal axis and vertical axis but significantly different lateral excursion relative to the seat. In addition, no spinal elongation was observed for THUMS compared to the PMHS. The posture, pretension, and belt frictions were found to alter model kinematics, especially on THUMS lateral axis motion. The posture was judged to be the most sensitive parameter evaluated because a change of 30 mm in the lateral axis results in up to an 80 mm of change in observed displacement. CONCLUSIONS: Though the model response in the lateral axis is significantly different than that of the PMHS, it is unclear whether this difference is the result of extrinsic factors (posture, pretension, and friction), where exact values in experiment are unknown or by model intrinsic factors (e.g., spine stiffness). These differences in occupant kinematics could potentially subject the PMHS and THUMS to very different loading conditions under roof impact in rollover crashes: different occupant posture and different roof impact location. Therefore, different injury mechanisms and severity might be predicted by the current model relative to the PMHS. Consequently, though the information provided in the current study could be useful for improving model biofidelity for rollover crashes, additional studies are required to properly solve this issue. FAU - Poulard, David AU - Poulard D AD - a University of Virginia, Center for Applied Biomechanics , Charlottesville , Virginia. FAU - Zhang, Qi AU - Zhang Q AD - a University of Virginia, Center for Applied Biomechanics , Charlottesville , Virginia. FAU - Cochran, Jack Ryan AU - Cochran JR AD - a University of Virginia, Center for Applied Biomechanics , Charlottesville , Virginia. FAU - Gepner, Bronislaw AU - Gepner B AD - a University of Virginia, Center for Applied Biomechanics , Charlottesville , Virginia. FAU - Kerrigan, Jason AU - Kerrigan J AD - a University of Virginia, Center for Applied Biomechanics , Charlottesville , Virginia. LA - eng PT - Evaluation Study PT - Journal Article PL - England TA - Traffic Inj Prev JT - Traffic injury prevention JID - 101144385 SB - IM MH - Accidents, Traffic/*statistics & numerical data MH - Biomechanical Phenomena MH - *Cadaver MH - Computer Simulation MH - Head/*physiology MH - Humans MH - Male MH - *Models, Biological MH - Posture/*physiology MH - Reproducibility of Results MH - Seat Belts MH - Spine/*physiology MH - Weight-Bearing OTO - NOTNLM OT - CORA OT - Rollover OT - biofidelity OT - human body model OT - kinematics EDAT- 2016/09/03 06:00 MHDA- 2017/07/08 06:00 CRDT- 2016/09/03 06:00 PHST- 2016/09/03 06:00 [entrez] PHST- 2016/09/03 06:00 [pubmed] PHST- 2017/07/08 06:00 [medline] AID - 10.1080/15389588.2016.1192282 [doi] PST - ppublish SO - Traffic Inj Prev. 2016 Sep;17 Suppl 1:101-8. doi: 10.1080/15389588.2016.1192282. PMID- 25371340 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20141105 LR - 20231110 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 3 IP - 1 DP - 2013 Feb 25 TI - A Laboratory of Extremophiles: Iceland Coordination Action for Research Activities on Life in Extreme Environments (CAREX) Field Campaign. PG - 211-33 LID - 10.3390/life3010211 [doi] AB - Existence of life in extreme environments has been known for a long time, and their habitants have been investigated by different scientific disciplines for decades. However, reports of multidisciplinary research are uncommon. In this paper, we report an interdisciplinary three-day field campaign conducted in the framework of the Coordination Action for Research Activities on Life in Extreme Environments (CAREX) FP7EU program, with participation of experts in the fields of life and earth sciences. In situ experiments and sampling were performed in a 20 m long hot springs system of different temperature (57 °C to 100 °C) and pH (2 to 4). Abiotic factors were measured to study their influence on the diversity. The CO2 and H2S concentration varied at different sampling locations in the system, but the SO2 remained the same. Four biofilms, mainly composed by four different algae and phototrophic protists, showed differences in photosynthetic activity. Varying temperature of the sampling location affects chlorophyll fluorescence, not only in the microbial mats, but plants (Juncus), indicating selective adaptation to the environmental conditions. Quantitative polymerase chain reaction (PCR), DNA microarray and denaturing gradient gel electrophoresis (DGGE)-based analysis in laboratory showed the presence of a diverse microbial population. Even a short duration (30 h) deployment of a micro colonizer in this hot spring system led to colonization of microorganisms based on ribosomal intergenic spacer (RISA) analysis. Polyphasic analysis of this hot spring system was possible due to the involvement of multidisciplinary approaches. FAU - Marteinsson, Viggó AU - Marteinsson V AD - Matis ohf. Food Safety, Environment and Genetics, Vinlandsleid 12, Reykjavik, 113, Iceland. viggo.th.marteinsson@matis.is. FAU - Vaishampayan, Parag AU - Vaishampayan P AD - Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California, Institute of Technology, Pasadena, CA 91109, USA. parag.A.Vaishampayan@jpl.nasa.gov. FAU - Kviderova, Jana AU - Kviderova J AD - Institute of Botany AS CR, Dukelská 135, Třeboň, CZ-379 82, Czech Republic. kviderova@butbn.cas.cz. FAU - Mapelli, Francesca AU - Mapelli F AD - Department of Food, Environment and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, Milan, 20133, Italy. francesca.mapelli@unimi.it. FAU - Medori, Mauro AU - Medori M AD - Consiglio NazionaledelleRicercheIstituto di BiologiaAgroambientale e Forestale via Marconi 2-05010 Porano (TR), Italy. mauro.medori@ibaf.cnr.it. FAU - Calfapietra, Carlo AU - Calfapietra C AD - Consiglio NazionaledelleRicercheIstituto di BiologiaAgroambientale e Forestale via Marconi 2-05010 Porano (TR), Italy. carlo.calfapietra@ibaf.cnr.it. FAU - Aguilera, Angeles AU - Aguilera A AD - Centro de Astrobiología. INTA-CSIC. Torrenjón de Ardoz, Madrid, 28850, Spain. aguileraba@cab.inta-csic.es. FAU - Hamisch, Domenica AU - Hamisch D AD - Department of Plant Biology Technical University of Braunschweig, Pockelsstr. 14, Brunschweig, 38092, Germany. d.hamisch@tu-bs.de. FAU - Reynisson, Eyjólfur AU - Reynisson E AD - Matis ohf. Food Safety, Environment and Genetics, Vinlandsleid 12, Reykjavik, 113, Iceland. eyjolfur@matis.is. FAU - Magnússon, Sveinn AU - Magnússon S AD - Matis ohf. Food Safety, Environment and Genetics, Vinlandsleid 12, Reykjavik, 113, Iceland. Sveinn.h.magnusson@matis.is. FAU - Marasco, Ramona AU - Marasco R AD - Department of Food, Environment and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, Milan, 20133, Italy. ramona.marasco@unimi.it. FAU - Borin, Sara AU - Borin S AD - Department of Food, Environment and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, Milan, 20133, Italy. sara.borin@unimi.it. FAU - Calzada, Abigail AU - Calzada A AD - Geology Department, University of Oviedo, Jesús Arias de Velasc, Oviedo, 33005, Spain. abigailcalzada@gmail.com. FAU - Souza-Egipsy, Virginia AU - Souza-Egipsy V AD - Centro de Astrobiología. INTA-CSIC. Torrenjón de Ardoz, Madrid, 28850, Spain. FAU - González-Toril, Elena AU - González-Toril E AD - Centro de Astrobiología. INTA-CSIC. Torrenjón de Ardoz, Madrid, 28850, Spain. FAU - Amils, Ricardo AU - Amils R AD - Centro de Astrobiología. INTA-CSIC. Torrenjón de Ardoz, Madrid, 28850, Spain. ramils@cbm.uam.es. FAU - Elster, Josef AU - Elster J AD - Institute of Botany AS CR, Dukelská 135, Třeboň, CZ-379 82, Czech Republic. jelster@butbn.cas.cz. FAU - Hänsch, Robert AU - Hänsch R AD - Department of Plant Biology Technical University of Braunschweig, Pockelsstr. 14, Brunschweig, 38092, Germany. r.haensch@tu-braunschweig.de. LA - eng PT - Journal Article DEP - 20130225 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC4187199 EDAT- 2013/01/01 00:00 MHDA- 2013/01/01 00:01 PMCR- 2013/03/01 CRDT- 2014/11/06 06:00 PHST- 2012/12/10 00:00 [received] PHST- 2013/01/23 00:00 [revised] PHST- 2013/02/05 00:00 [accepted] PHST- 2014/11/06 06:00 [entrez] PHST- 2013/01/01 00:00 [pubmed] PHST- 2013/01/01 00:01 [medline] PHST- 2013/03/01 00:00 [pmc-release] AID - life3010211 [pii] AID - life-03-00211 [pii] AID - 10.3390/life3010211 [doi] PST - epublish SO - Life (Basel). 2013 Feb 25;3(1):211-33. doi: 10.3390/life3010211. PMID- 30902085 OWN - NLM STAT- MEDLINE DCOM- 20190718 LR - 20200225 IS - 1471-2490 (Electronic) IS - 1471-2490 (Linking) VI - 19 IP - 1 DP - 2019 Mar 22 TI - Intrarenal arteriovenous malformation following flexible ureterorenoscopy and holmium laser stone fragmentation: report of a case. PG - 20 LID - 10.1186/s12894-019-0447-7 [doi] LID - 20 AB - BACKGROUND: Flexible ureterorenoscopy (FURS) and holmium laser lithotripsy is currently considered as one of the treatment options for large renal calculi. It has been shown to be safer than percutaneous nephrolithotomy. The latter can sometimes be complicated by the formation of intrarenal arteriovenous malformation (AVM). AVM is extremely rare following FURS and laser lithotripsy. Indeed only one case has been reported on reviewing the literature up to June 2018. We report on the second case illustrating the possibility of developing this major complication following this procedure. CASE PRESENTATION: A 79 years old diabetic and hypertensive male with stage-4 chronic kidney disease who previously had left extracorporeal shockwave lithotripsy and FURS with Holmium laser lithotripsy, presented with bilateral large renal calculi. He underwent simultaneous bilateral FURS and Holmium laser lithotripsy and was discharged home the following day with almost clear urine. Four days post-discharge, he presented with gross hematuria for which he required hospitalization and blood transfusion. CT scan demonstrated left subcapsular, perinephric and retroperitoneal hematoma. Angiography showed contrast extravasation from pseudoaneurysms in two small branches of left renal artery. Both were selectively embolized with micro-coils and this led to the cessation of the hematuria. CONCLUSIONS: Despite the relative safety of FURS and Holmium laser lithotripsy, it can be associated with major complications like intrarenal AVM. This can probably be prevented by careful and judicious use of laser energy in patients with large stone burden and premorbid conditions. FAU - Bashar, Abdelrahman AU - Bashar A AD - Urology Division, Tawam Hospital in affiliation with Johns Hopkins Medicine, Al Ain, UAE. FAU - Hammad, Fayez T AU - Hammad FT AD - Department of Surgery, College of Medicine and Health Sciences, United Arab Emirates University, Po Box 17666, Al Ain, UAE. fayezhammad@hotmail.com. LA - eng GR - -/None/ PT - Case Reports PT - Journal Article DEP - 20190322 PL - England TA - BMC Urol JT - BMC urology JID - 100968571 SB - IM MH - Aged MH - Arteriovenous Malformations/diagnostic imaging/*surgery MH - Humans MH - Kidney Calculi/diagnostic imaging/*surgery MH - Lasers, Solid-State/*therapeutic use MH - Lithotripsy, Laser/*methods MH - Male MH - Ureteroscopy/*methods PMC - PMC6429714 OTO - NOTNLM OT - Arteriovenous malformation OT - Flexible ureterorenoscopy OT - Holmium laser COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not Applicable. CONSENT FOR PUBLICATION: Written informed consent was obtained from the patient for publication of this Case Report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal. COMPETING INTERESTS: None of the authors has any conflict of interest to disclose. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. EDAT- 2019/03/25 06:00 MHDA- 2019/07/19 06:00 PMCR- 2019/03/22 CRDT- 2019/03/24 06:00 PHST- 2018/06/21 00:00 [received] PHST- 2019/03/07 00:00 [accepted] PHST- 2019/03/24 06:00 [entrez] PHST- 2019/03/25 06:00 [pubmed] PHST- 2019/07/19 06:00 [medline] PHST- 2019/03/22 00:00 [pmc-release] AID - 10.1186/s12894-019-0447-7 [pii] AID - 447 [pii] AID - 10.1186/s12894-019-0447-7 [doi] PST - epublish SO - BMC Urol. 2019 Mar 22;19(1):20. doi: 10.1186/s12894-019-0447-7. PMID- 32821873 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231112 IS - 2471-1403 (Electronic) IS - 2471-1403 (Linking) VI - 4 IP - 8 DP - 2020 Aug TI - Association Between Work-Related Hyperthermia Emergency Department Visits and Ambient Heat in Five Southeastern States, 2010-2012-A Case-Crossover Study. PG - e2019GH000241 LID - 10.1029/2019GH000241 [doi] LID - e2019GH000241 AB - The objective of this study is to assess ambient temperatures' and extreme heat events' contribution to work-related emergency department (ED) visits for hyperthermia in the southeastern United States to inform prevention. Through a collaborative network and established data framework, work-related ED hyperthermia visits in five participating southeastern U.S. states were analyzed using a time stratified case-crossover design. For exposure metrics, day- and location-specific measures of ambient temperatures and county-specific identification of extreme heat events were used. From 2010 to 2012, 5,017 work-related hyperthermia ED visits were seen; 2,298 (~46%) of these visits occurred on days when the daily maximum heat index was at temperatures the Occupational Safety and Health Administration designates as having "lower" or "moderate" heat risk. A 14% increase in risk of ED visit was seen for a 1°F increase in average daily mean temperature, modeled as linear predictor across all temperatures. A 54% increase in risk was seen for work-related hyperthermia ED visits during extreme heat events (two or more consecutive days of unusually high temperatures) when controlling for average daily mean temperature. Despite ambient heat being a well-known risk to workers' health, this study's findings indicate ambient heat contributed to work-related ED hyperthermia visits in these five states. Used alone, existing OSHA heat-risk levels for ambient temperatures did not appear to successfully communicate workers' risk for hyperthermia in this study. Findings should inform future heat-alert communications and policies, heat prevention efforts, and heat-illness prevention research for workers in the southeastern United States. CI - ©2020. The Authors. FAU - Shire, Jeffrey AU - Shire J AUID- ORCID: 0000-0002-1310-228X AD - National Institute for Occupational Safety and Health Centers for Disease Control and Prevention Cincinnati OH USA. FAU - Vaidyanathan, Ambarish AU - Vaidyanathan A AUID- ORCID: 0000-0002-7427-5256 AD - National Center for Environmental Health Centers for Disease Control and Prevention Atlanta GA USA. FAU - Lackovic, Michelle AU - Lackovic M AUID- ORCID: 0000-0002-6067-9364 AD - Louisiana Public Health Institute New Orleans LA. FAU - Bunn, Terry AU - Bunn T AUID- ORCID: 0000-0002-5948-3313 AD - Kentucky Injury Prevention and Research Center, Department of Preventive Medicine and Environmental Health University of Kentucky College of Public Health Lexington KY USA. LA - eng GR - U60 OH008483/OH/NIOSH CDC HHS/United States PT - Journal Article DEP - 20200816 PL - United States TA - Geohealth JT - GeoHealth JID - 101706476 PMC - PMC7429406 OTO - NOTNLM OT - ambient temperature OT - case‐crossover OT - extreme heat OT - heat stress disorders OT - primary prevention OT - workers COIS- The authors declare no conflict of interest relevant to this study. EDAT- 2020/08/22 06:00 MHDA- 2020/08/22 06:01 PMCR- 2020/08/16 CRDT- 2020/08/22 06:00 PHST- 2019/12/30 00:00 [received] PHST- 2020/06/10 00:00 [revised] PHST- 2020/07/12 00:00 [accepted] PHST- 2020/08/22 06:00 [entrez] PHST- 2020/08/22 06:00 [pubmed] PHST- 2020/08/22 06:01 [medline] PHST- 2020/08/16 00:00 [pmc-release] AID - GH2182 [pii] AID - 10.1029/2019GH000241 [doi] PST - epublish SO - Geohealth. 2020 Aug 16;4(8):e2019GH000241. doi: 10.1029/2019GH000241. eCollection 2020 Aug. PMID- 680394 OWN - NLM STAT- MEDLINE DCOM- 19781027 LR - 20041117 IS - 0301-5149 (Print) IS - 0301-5149 (Linking) VI - 40 DP - 1978 TI - Standardization of methods used for testing the safety of tissue culture rabies vaccines. PG - 209-13 AB - Tissue culture rabies vaccines are essentially new preparations intended for prophylaxis and treatment of rabies. However, the methods used for their testing are mostly the same as those used for rabies vaccines prepared from brain tissue. Therefore, it is extremely important to develop and standardize methods for testing tissue culture rabies vaccines. The main criteria for the evaluation of Vnukovo-32 production strain have been formulated. The strain has been characterized in pathomorphological studies; the degree and nature of lesions produced in animal brain tissue by various doses of antigen and different routes of inoculation have been determined. In order to ensure the specific innocuity of rabies vaccines inactivated preparations are produced. However, with the current methods of inactivation (treatment with beta-propiolactone or phenol, ultraviolet irradiation and others) some viral particles may occasionally remain active. Besides, reparative processes may possibly occur in utraviolet-irradiated viruses. The penetration of even sublethal doses of live virus into the body is highly undesirable, since under certain conditions the long-term harbouring of the live viral particle may result in the development of various pathological conditions. In order to reveal minimum amounts of live virus in the preparation a method of additional passages in a susceptible cell system using the fluorescent antibody technique has been developed. By this method it has been possible to detect the presence of live virus in 10 out of 51 lots of vaccine under test. FAU - Romanova, L N AU - Romanova LN FAU - Polyushkina, G S AU - Polyushkina GS LA - eng PT - Journal Article PL - Switzerland TA - Dev Biol Stand JT - Developments in biological standardization JID - 0427140 RN - 0 (Rabies Vaccines) SB - IM MH - Animals MH - Antibody Formation MH - Culture Techniques MH - Mice MH - Rabies Vaccines/immunology/*standards MH - Rabies virus/isolation & purification EDAT- 1978/01/01 00:00 MHDA- 1978/01/01 00:01 CRDT- 1978/01/01 00:00 PHST- 1978/01/01 00:00 [pubmed] PHST- 1978/01/01 00:01 [medline] PHST- 1978/01/01 00:00 [entrez] PST - ppublish SO - Dev Biol Stand. 1978;40:209-13. PMID- 18698873 OWN - NLM STAT- MEDLINE DCOM- 20081218 LR - 20211020 IS - 1172-7047 (Print) IS - 1172-7047 (Linking) VI - 22 IP - 9 DP - 2008 TI - Use of botulinum toxin A in adult neurological disorders: efficacy, tolerability and safety. PG - 725-38 AB - The protein botulinum neurotoxin A (BoNT/A) is one of seven distinct neurotoxins produced by Clostridium botulinum. BoNT/A blocks cholinergic synapses with an extremely high specificity and potency. Appropriately purified and diluted, BoNT/A serves as a reliable and well tolerated drug that is applied by local injection.The efficacy of BoNT/A is evident in the symptomatic therapy of disorders in which muscular hyperactivity plays a prominent role, such as focal dystonias and hemifacial spasm; in these disorders, BoNT/A is considered first-line therapy. BoNT/A is also beneficial in the treatment of both adults and children with spasticity of various causes. The pain that frequently accompanies these conditions is effectively reduced by BoNT/A. A genuine analgesic effect for BoNT/A unrelated to skeletal muscle spasmolysis has been suggested on the basis of in vitro and in vivo (animal) data. However, studies in humans designed to detect such an effect were negative, as were controlled studies of BoNT/A in patients with primary headache disorders.BoNT/A also acts on cholinergic synapses of the autonomic nervous system, and injection of BoNT/A into salivary glands significantly decreases the production of saliva. This may be beneficial for patients with Parkinson's disease, in whom the excessive production of saliva may be problematic.Overall, BoNT/A has been confirmed as an efficacious, predictable and well tolerated drug in an ever-increasing number of neurological disorders. FAU - Schulte-Mattler, Wilhelm J AU - Schulte-Mattler WJ AD - Department of Neurology, University of Regensburg, Regensburg, Germany. wilhelm.schulte-mattler@klinik.uni-regensburg.de LA - eng PT - Journal Article PT - Review PL - New Zealand TA - CNS Drugs JT - CNS drugs JID - 9431220 RN - 0 (Neuromuscular Agents) RN - EC 3.4.24.69 (Botulinum Toxins, Type A) SB - IM MH - Botulinum Toxins, Type A/pharmacology/*therapeutic use MH - Humans MH - Nervous System Diseases/*drug therapy MH - Neuromuscular Agents/pharmacology/*therapeutic use RF - 111 EDAT- 2008/08/14 09:00 MHDA- 2008/12/19 09:00 CRDT- 2008/08/14 09:00 PHST- 2008/08/14 09:00 [pubmed] PHST- 2008/12/19 09:00 [medline] PHST- 2008/08/14 09:00 [entrez] AID - 2292 [pii] AID - 10.2165/00023210-200822090-00002 [doi] PST - ppublish SO - CNS Drugs. 2008;22(9):725-38. doi: 10.2165/00023210-200822090-00002. PMID- 23770904 OWN - NLM STAT- MEDLINE DCOM- 20140310 LR - 20211021 IS - 1098-5336 (Electronic) IS - 0099-2240 (Print) IS - 0099-2240 (Linking) VI - 79 IP - 18 DP - 2013 Sep TI - Evidence of metabolic switching and implications for food safety from the phenome(s) of Salmonella enterica serovar Typhimurium DT104 cultured at selected points across the pork production food chain. PG - 5437-49 LID - 10.1128/AEM.01041-13 [doi] AB - Salmonella enterica serovar Typhimurium DT104 is a recognized food-borne pathogen that displays a multidrug-resistant phenotype and that is associated with systemic infections. At one extreme of the food chain, this bacterium can infect humans, limiting the treatment options available and thereby contributing to increased morbidity and mortality. Although the antibiotic resistance profile is well defined, little is known about other phenotypes that may be expressed by this pathogen at key points across the pork production food chain. In this study, 172 Salmonella enterica serovar Typhimurium DT104/DT104b isolated from an extensive "farm-to-fork" surveillance study, focusing on the pork food chain, were characterized in detail. Isolates were cultured from environmental, processing, retail, and clinical sources, and the study focused on phenotypes that may have contributed to persistence/survival in these different niches. Molecular subtypes, along with antibiotic resistance profiles, tolerance to biocides, motility, and biofilm formation, were determined. As a basis for human infection, acid survival and the ability to utilize a range of energy sources and to adhere to and/or invade Caco-2 cells were also studied. Comparative alterations to biocide tolerance were observed in isolates from retail. l-Tartaric acid and d-mannose-1-phosphate induced the formation of biofilms in a preselected subset of strains, independent of their origin. All clinical isolates were motile and demonstrated an enhanced ability to survive in acidic conditions. Our data report on a diverse phenotype, expressed by S. Typhimurium isolates cultured from the pork production food chain. Extending our understanding of the means by which this pathogen adapts to environmental niches along the "farm-to-fork" continuum will facilitate the protection of vulnerable consumers through targeted improvements in food safety measures. FAU - Martins, Marta AU - Martins M AD - UCD Centre for Food Safety, School of Public Health, Physiotherapy and Population Science, University College Dublin, Belfield, Dublin, Ireland. FAU - McCusker, Matthew P AU - McCusker MP FAU - McCabe, Evonne M AU - McCabe EM FAU - O'Leary, Denis AU - O'Leary D FAU - Duffy, Geraldine AU - Duffy G FAU - Fanning, Séamus AU - Fanning S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130614 PL - United States TA - Appl Environ Microbiol JT - Applied and environmental microbiology JID - 7605801 SB - IM MH - Animals MH - Bacterial Adhesion MH - Biofilms/growth & development MH - Drug Tolerance MH - *Environmental Microbiology MH - Epithelial Cells/microbiology MH - Food Handling MH - *Food Safety MH - Humans MH - Locomotion MH - Meat/*microbiology MH - Microbial Sensitivity Tests MH - Molecular Typing MH - Phenotype MH - Salmonella Food Poisoning/*microbiology MH - Salmonella typhimurium/*isolation & purification/*physiology MH - Swine PMC - PMC3754156 EDAT- 2013/06/19 06:00 MHDA- 2014/03/13 06:00 PMCR- 2014/03/01 CRDT- 2013/06/18 06:00 PHST- 2013/06/18 06:00 [entrez] PHST- 2013/06/19 06:00 [pubmed] PHST- 2014/03/13 06:00 [medline] PHST- 2014/03/01 00:00 [pmc-release] AID - AEM.01041-13 [pii] AID - 01041-13 [pii] AID - 10.1128/AEM.01041-13 [doi] PST - ppublish SO - Appl Environ Microbiol. 2013 Sep;79(18):5437-49. doi: 10.1128/AEM.01041-13. Epub 2013 Jun 14. PMID- 7290462 OWN - NLM STAT- MEDLINE DCOM- 19811221 LR - 20131121 IS - 0026-4806 (Print) IS - 0026-4806 (Linking) VI - 72 IP - 38 DP - 1981 Oct 6 TI - [The effects of small amounts of alcohol on in-flight activity]. PG - 2571-86 AB - Alcohol metabolism is described prior to an account of its effect on vigilance. The psychological and psychosomatic influence of alcohol is also illustrated in the light of experimental data indicating how it alters the response to stimuli. Alterations in various parameters following the administration of significantly small doses of alcohol were studied. Reaction time decreased, then increased, followed by a further decrease after about 1 1/2 hr. Even 1/8th litre depresses receptiveness of the reticular substance, and leads to lengthening of reaction times due to diminished ability to concentrate attention on a given task. CNS depression is also in proportion to the complexity of the performance required. This is particularly and dangerous in pilots, whose tasks are extremely precise and require close attention. Functional alterations induced by alcohol during flight may be numerous, due to disturbances connected with the specific conditions created by flying, and apparatuses whose physiological functions are susceptible to disturbance by flying itself. Alcohol, itself a harmful influence on piloting an aircraft, deteriorates these functions and conditions. Toxic substances present during flying and their potentiation by alcohol are considered. The effects of alcohol, added to these specific pathogenetic toxic effects, quickly and readily lead to a fall in overall psychophysical efficiency, and prejudice flight safety. the reason why a decrease in the limit intake doses to less than 2 cc/kg, equivalent to a blood value of 0.5 g 0/00, to ensure safe control of the plane, is desirable is explained. FAU - Dionisi, A AU - Dionisi A LA - ita PT - English Abstract PT - Journal Article TT - Effetti dell'assunzione di piccole dosi di alcool sulla attività di volo. PL - Italy TA - Minerva Med JT - Minerva medica JID - 0400732 RN - 0 (Gasoline) RN - 3K9958V90M (Ethanol) SB - IM MH - *Aerospace Medicine MH - *Alcohol Drinking MH - Awareness/drug effects MH - Central Nervous System/drug effects MH - Drug Synergism MH - Ethanol/*adverse effects/metabolism MH - Gasoline/toxicity MH - Humans MH - Reaction Time/drug effects EDAT- 1981/10/06 00:00 MHDA- 1981/10/06 00:01 CRDT- 1981/10/06 00:00 PHST- 1981/10/06 00:00 [pubmed] PHST- 1981/10/06 00:01 [medline] PHST- 1981/10/06 00:00 [entrez] PST - ppublish SO - Minerva Med. 1981 Oct 6;72(38):2571-86. PMID- 22893599 OWN - NLM STAT- MEDLINE DCOM- 20130317 LR - 20141120 IS - 1531-4995 (Electronic) IS - 0023-852X (Linking) VI - 123 IP - 1 DP - 2013 Jan TI - Low-frequency ultrasound for biofilm disruption in chronic rhinosinusitis with nasal polyposis: in vitro pilot study. PG - 17-23 LID - 10.1002/lary.23633 [doi] AB - OBJECTIVES/HYPOTHESIS: Microbial biofilms have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). Although biofilms are characterized by an extremely high resistance against chemical and physical agents, low-frequency ultrasound (LFU) treatment has been suspected to be an efficient and safe method for biofilm disruption. STUDY DESIGN: Basic science experimental study. METHODS: A total of 10 patients with CRSwNP undergoing endoscopic sinus surgery were analyzed. Two series of identical nasal polyps (n = 20) were processed to hematoxylin-eosin (HE) and Gram staining and to continuous-wave LFU treatment (5 minutes, 0.4 MHz, 37°C), respectively. RESULTS: Presence of microbial biofilms was confirmed in all patients with CRSwNP. HE staining showed a strong correlation with the results of Gram protocol in biofilm detection. In the LFU-treated group (n = 10), a significantly decreased inflammatory cell count was found in the subepithelial layer of nasal polyps (P < .001). In addition, bacterial biofilms were completely removed from the surface of the epithelial layer. Microscopic tissue injuries or significant temperature changes were not detected due to LFU treatment. CONCLUSIONS: Between in vitro conditions, LFU treatment appeared to be a reliable and microscopically safe method for the disruption of microbial biofilms in CRSwNP. These results may provide a basis for a prospective human study investigating the efficacy and safety of this therapeutic modality alone or in combination with antibiotics or topical steroids in biofilm-positive cases of CRSwNP. CI - Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc. FAU - Karosi, Tamás AU - Karosi T AD - Department of Otolaryngology and Head and Neck Surgery, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary. karositamas@gmail.com FAU - Sziklai, István AU - Sziklai I FAU - Csomor, Péter AU - Csomor P LA - eng PT - Journal Article DEP - 20120814 PL - United States TA - Laryngoscope JT - The Laryngoscope JID - 8607378 RN - TDQ283MPCW (Eosine Yellowish-(YS)) RN - YKM8PY2Z55 (Hematoxylin) SB - IM MH - Adult MH - Biofilms/*growth & development MH - Case-Control Studies MH - Chronic Disease MH - Eosine Yellowish-(YS) MH - Female MH - Hematoxylin MH - Humans MH - In Vitro Techniques MH - Male MH - Middle Aged MH - Nasal Polyps/microbiology/*therapy MH - Pilot Projects MH - Rhinitis/microbiology/*therapy MH - Sinusitis/microbiology/*therapy MH - Ultrasonic Therapy/*methods EDAT- 2012/08/16 06:00 MHDA- 2013/03/19 06:00 CRDT- 2012/08/16 06:00 PHST- 2012/05/16 00:00 [received] PHST- 2012/06/29 00:00 [revised] PHST- 2012/07/09 00:00 [accepted] PHST- 2012/08/16 06:00 [entrez] PHST- 2012/08/16 06:00 [pubmed] PHST- 2013/03/19 06:00 [medline] AID - 10.1002/lary.23633 [doi] PST - ppublish SO - Laryngoscope. 2013 Jan;123(1):17-23. doi: 10.1002/lary.23633. Epub 2012 Aug 14. PMID- 37718303 OWN - NLM STAT- MEDLINE DCOM- 20230919 LR - 20241001 IS - 1833-3516 (Print) IS - 2209-1491 (Electronic) IS - 1833-3516 (Linking) VI - 53 IP - 3 DP - 2023 Sep 30 TI - Investigation into the effect of hyperbaric hyperoxia on serum cardiac Troponin T levels as a biomarker of cardiac injury. PG - 281-284 LID - 10.28920/dhm53.3.281-284 [doi] AB - INTRODUCTION: There is clinical equipoise as to whether hyperoxia is injurious to the myocardium, both in the setting of acute ischaemic insults and on the stable myocardium. This study examined the effect of extreme hyperoxia - in the form of hyperbaric oxygen treatment - on the myocardium through measurement of high-sensitivity cardiac troponin. METHODS: Forty-eight individuals were enrolled to undergo a series of 30 exposures to hyperbaric oxygen for treatment of non-cardiac pathologies. High-sensitivity troponin T was measured before and after each session. RESULTS: There was no clinically significant difference in troponin measurements following acute or recurrent sequential exposures to extreme hyperoxia, despite the studied patient population having a high rate of previous ischaemic heart disease or cardiovascular risk factors. CONCLUSIONS: This study demonstrates that profound hyperoxaemia does not induce any measurable cardiac injury at a biochemical level. Neither is there a reduction in cardiac troponin to suggest a cardioprotective effect of hyperbaric hyperoxia. This provides some reassurance as to the cardiac safety of the routine use of hyperbaric oxygen treatment in management of non-cardiac pathology. CI - Copyright: This article is the copyright of the authors who grant Diving and Hyperbaric Medicine a non-exclusive licence to publish the article in electronic and other forms. FAU - Marjot, Jack AU - Marjot J AD - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney. AD - Corresponding author: Dr Jack Marjot, Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney, Australia, ORCiD ID: 0009-0002-0212-1343. jack.marjot@health.nsw.gov.au. FAU - Mackenzie, John AU - Mackenzie J AD - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney. FAU - Jepson, Nigel AU - Jepson N AD - Department of Cardiology, Prince of Wales Hospital, Sydney. FAU - Reeves, Ewan AU - Reeves E AD - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney. FAU - Bennett, Michael AU - Bennett M AD - Department of Diving and Hyperbaric Medicine, Prince of Wales Hospital, Sydney. LA - eng PT - Journal Article PL - Australia TA - Diving Hyperb Med JT - Diving and hyperbaric medicine JID - 101282742 RN - 0 (Troponin T) RN - S88TT14065 (Oxygen) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Hyperoxia MH - Troponin T MH - Oxygen MH - Biomarkers MH - *Hyperbaric Oxygenation PMC - PMC10735667 OTO - NOTNLM OT - Biomarkers OT - Cardiovascular OT - Health OT - Heart OT - Hyperbaric oxygen treatment COIS- Conflict of interest and funding: Roche provided discounted assay reagents but had no role in study design or implementation, or in analysis of results. EDAT- 2023/09/18 00:41 MHDA- 2023/09/19 06:42 PMCR- 2024/09/30 CRDT- 2023/09/17 22:53 PHST- 2023/06/30 00:00 [received] PHST- 2023/08/12 00:00 [accepted] PHST- 2023/09/19 06:42 [medline] PHST- 2023/09/18 00:41 [pubmed] PHST- 2023/09/17 22:53 [entrez] PHST- 2024/09/30 00:00 [pmc-release] AID - 10.28920/dhm53.3.281-284 [doi] PST - ppublish SO - Diving Hyperb Med. 2023 Sep 30;53(3):281-284. doi: 10.28920/dhm53.3.281-284. PMID- 26548380 OWN - NLM STAT- MEDLINE DCOM- 20170731 LR - 20181202 IS - 2151-4658 (Electronic) IS - 2151-464X (Linking) VI - 68 IP - 5 DP - 2016 May TI - Efficacy, Tolerability, and Safety of Cannabinoid Treatments in the Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials. PG - 681-8 LID - 10.1002/acr.22727 [doi] AB - OBJECTIVE: To assess the efficacy, tolerability, and safety of cannabinoids (phyto- and syntheto-) in the management of rheumatic diseases. METHODS: Multiple databases, including Medline, Embase, and CENTRAL, were searched. Randomized controlled trials with outcomes of pain, sleep, quality of life, tolerability (dropouts due to adverse events), and safety (serious adverse events), with comparison of cannabinoids with any type of control, were included. Study methodology quality was evaluated with the Cochrane risk of bias tool. RESULTS: In 4 short-term studies comprising 203 patients (58 with rheumatoid arthritis, 71 with fibromyalgia, and 74 with osteoarthritis [OA]), cannabinoids had a statistically significant effect on pain in 2, sleep in 2, and improved quality of life in 1, with the OA study prematurely terminated due to futility. The risk of bias was high for all 3 completed studies. Dizziness, cognitive problems, and drowsiness, as well as nausea, were reported for almost half of the patients. No serious adverse events were reported for cannabinoids during the study duration. No studies of herbal cannabis were identified. CONCLUSION: Extremely small sample sizes, short study duration, heterogeneity of rheumatic conditions and products, and absence of studies of herbal cannabis allow for only limited conclusions for the effects of cannabinoids in rheumatic conditions. Pain relief and effect on sleep may have some potential therapeutic benefit, but with considerable mild to moderate adverse events. There is currently insufficient evidence to recommend cannabinoid treatments for management of rheumatic diseases pending further study. CI - © 2016, American College of Rheumatology. FAU - Fitzcharles, Mary-Ann AU - Fitzcharles MA AD - McGill University Health Centre, Montreal, Quebec, Canada. FAU - Ste-Marie, Peter A AU - Ste-Marie PA AD - McGill University Health Centre, Montreal, Quebec, Canada. FAU - Häuser, Winfried AU - Häuser W AD - Klinikum Saarbrücken, Saarbrücken, and Technische Universität München, München, Germany. FAU - Clauw, Daniel J AU - Clauw DJ AD - University of Michigan Medical Center, Ann Arbor. FAU - Jamal, Shahin AU - Jamal S AD - University of British Columbia, Vancouver, British Columbia, Canada. FAU - Karsh, Jacob AU - Karsh J AD - The Ottawa Hospital, Ottawa, Ontario, Canada. FAU - Landry, Tara AU - Landry T AD - McGill University Health Centre and Montreal General Hospital Medical Library, Montreal, Quebec, Canada. FAU - Leclercq, Sharon AU - Leclercq S AD - University of Calgary, Calgary, Alberta, Canada. FAU - Mcdougall, Jason J AU - Mcdougall JJ AD - Dalhousie University, Halifax, Nova Scotia, Canada. FAU - Shir, Yoram AU - Shir Y AD - McGill University Health Centre, Montreal, Quebec, Canada. FAU - Shojania, Kam AU - Shojania K AD - University of British Columbia, Vancouver, and Arthritis Research Centre of Canada, Richmond, British Columbia, Canada. FAU - Walsh, Zach AU - Walsh Z AD - University of British Columbia, Vancouver, British Columbia, Canada. LA - eng PT - Journal Article PT - Review PT - Systematic Review PL - United States TA - Arthritis Care Res (Hoboken) JT - Arthritis care & research JID - 101518086 RN - 0 (Cannabinoids) SB - IM MH - Cannabinoids/*therapeutic use MH - Humans MH - Pain/drug therapy/etiology MH - Pain Management/*methods MH - Randomized Controlled Trials as Topic MH - Rheumatic Diseases/complications/*drug therapy MH - Sleep/drug effects MH - Treatment Outcome EDAT- 2015/11/10 06:00 MHDA- 2017/08/02 06:00 CRDT- 2015/11/10 06:00 PHST- 2015/06/23 00:00 [received] PHST- 2015/08/20 00:00 [revised] PHST- 2015/09/08 00:00 [accepted] PHST- 2015/11/10 06:00 [entrez] PHST- 2015/11/10 06:00 [pubmed] PHST- 2017/08/02 06:00 [medline] AID - 10.1002/acr.22727 [doi] PST - ppublish SO - Arthritis Care Res (Hoboken). 2016 May;68(5):681-8. doi: 10.1002/acr.22727. PMID- 32318723 OWN - NLM STAT- MEDLINE DCOM- 20201105 LR - 20230227 IS - 1944-9097 (Electronic) IS - 0362-028X (Linking) VI - 83 IP - 5 DP - 2020 May 1 TI - Temperature-Dependent Growth Characteristics of Bacillus thuringiensis in a Ratatouille Food Model. PG - 816-820 LID - 10.4315/0362-028X.JFP-19-358 [doi] AB - ABSTRACT: In contrast to Bacillus cereus, the role of Bacillus thuringiensis in foodborne illness has been controversially discussed. As B. thuringiensis-based biopesticides containing a mixture of crystal toxins and viable spores are widely used, a current European Food Safety Authority opinion underlines the need for additional data to enable risk assessment. However, it is currently poorly understood if B. thuringiensis is able to multiply in food, which is crucial to sound risk assessment. Therefore, the aim of this study was to investigate growth of selected B. thuringiensis strains from food and insecticides in a ratatouille food model. To this end, the growth parameters of three B. thuringiensis strains were determined: insecticide strain ABTS-351 (CH_119, B. thuringiensis serovar kurstaki), insecticide strain ABTS-1857 (CH_121, B. thuringiensis serovar aizawai), and CH_48 (wild-type B. thuringiensis isolated from rosemary), producing extremely high levels of enterotoxins. After an initial drop in colony counts, we observed a statistically significant growth for the tested B. thuringiensis strains between 6 and 24 h at 22, 30, and 37°C, conditions mimicking prolonged holding times. We were also able to show that the enterotoxin overproducer CH_48 can grow up to 108 CFU/g in the ratatouille matrix within 24 h at 37°C. The two midlevel enterotoxin formers ABTS-351 (CH_119) and ABTS-1857 (CH_121) isolated from biopesticides exhibited growth between 6 and 24 h, with one of the strains growing to 107 CFU/g. To our knowledge, this is the first study providing evidence of B. thuringiensis growth in a food model with intact competitive flora. Our findings suggest strain-specific variation and stress the complexity of assessing the risk related to B. thuringiensis in food, indicating that some strains can represent a risk to consumer health when vegetable-based foods are stored under conditions of prolonged temperature abuse. CI - Copyright ©, International Association for Food Protection. FAU - Heini, Nicole AU - Heini N AD - Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland. FAU - Stephan, Roger AU - Stephan R AD - Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland. FAU - Filter, Matthias AU - Filter M AD - German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany; and. FAU - Plaza-Rodriguez, Carolina AU - Plaza-Rodriguez C AD - German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany; and. FAU - Frentzel, Hendrik AU - Frentzel H AD - German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany; and. FAU - Ehling-Schulz, Monika AU - Ehling-Schulz M AD - Functional Microbiology, Institute of Microbiology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria. FAU - Johler, Sophia AU - Johler S AD - Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland. LA - eng PT - Journal Article PL - United States TA - J Food Prot JT - Journal of food protection JID - 7703944 RN - 0 (Enterotoxins) SB - IM MH - Bacillus cereus MH - *Bacillus thuringiensis/growth & development MH - Enterotoxins/*analysis MH - Food Microbiology MH - *Temperature MH - Vegetables/*microbiology OTO - NOTNLM OT - Bacillus thuringiensis OT - Food matrix OT - Food safety OT - Insecticide OT - Multiplication EDAT- 2020/04/23 06:00 MHDA- 2020/11/06 06:00 CRDT- 2020/04/23 06:00 PHST- 2019/08/02 00:00 [received] PHST- 2019/12/26 00:00 [accepted] PHST- 2020/04/23 06:00 [entrez] PHST- 2020/04/23 06:00 [pubmed] PHST- 2020/11/06 06:00 [medline] AID - S0362-028X(22)10295-4 [pii] AID - 10.4315/0362-028X.JFP-19-358 [doi] PST - ppublish SO - J Food Prot. 2020 May 1;83(5):816-820. doi: 10.4315/0362-028X.JFP-19-358. PMID- 22905326 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20121002 LR - 20220321 IS - 2152-7806 (Electronic) IS - 2229-5097 (Print) IS - 2152-7806 (Linking) VI - 3 IP - Suppl 3 DP - 2012 TI - The lateral transpsoas approach to the lumbar and thoracic spine: A review. PG - S198-215 LID - 10.4103/2152-7806.98583 [doi] AB - BACKGROUND: In the last several years, the lateral transpsoas approach to the thoracic and lumbar spine, also known as extreme lateral interbody fusion (XLIF) or direct lateral interbody fusion (DLIF), has become an increasingly common method to achieve fusion. Several recent large series describe several advantages to this approach, including less tissue dissection, smaller incisions, decreased operative time, blood loss, shorter hospital stay, reduced postoperative pain, enhanced fusion rates, and the ability to place instrumentation through the same incision. Indications for this approach have expanded and now include degenerative disease, tumor, deformity, and infection. METHODS: A lateral X-ray confirms that the patient is in a truly lateral position. Next, a series of tubes and dilators are used, along with fluoroscopy, to identify the mid-position of the disk to be incised. After continued dilation, the optimal site to enter the disk space is the midpoint of the disk, or a position slightly anterior to the midpoint of the disk. XLIF typically allows for a larger implant to be inserted compared to TLIF or PLIF, and, if necessary, instrumentation can be inserted percutaneously, which would allow for an overall minimally invasive procedure. RESULTS: Fixation techniques appear to be equal between XLIF and more traditional approaches. Some caution should be exercised because common fusion levels of the lumbar spine, including L4-5 and L4-S1, are often inaccessible. In addition, XLIF has a unique set of complications, including neural injuries, psoas weakness, and thigh numbness. CONCLUSION: Additional studies are required to further evaluate and monitor the short and long-term safety, efficacy, outcomes, and complications of XLIF procedures. FAU - Arnold, Paul M AU - Arnold PM AD - Department of Neurosurgery, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA. FAU - Anderson, Karen K AU - Anderson KK FAU - McGuire, Robert A Jr AU - McGuire RA Jr LA - eng PT - Journal Article DEP - 20120717 PL - United States TA - Surg Neurol Int JT - Surgical neurology international JID - 101535836 PMC - PMC3422088 OTO - NOTNLM OT - Lateral transpsoas approach OT - direct lateral interbody fusion OT - extreme lateral interbody fusion OT - lumbar spine OT - lumbosacral plexus OT - surgical technique EDAT- 2012/08/21 06:00 MHDA- 2012/08/21 06:01 PMCR- 2012/07/17 CRDT- 2012/08/21 06:00 PHST- 2012/05/16 00:00 [received] PHST- 2012/05/16 00:00 [accepted] PHST- 2012/08/21 06:00 [entrez] PHST- 2012/08/21 06:00 [pubmed] PHST- 2012/08/21 06:01 [medline] PHST- 2012/07/17 00:00 [pmc-release] AID - SNI-3-198 [pii] AID - 10.4103/2152-7806.98583 [doi] PST - ppublish SO - Surg Neurol Int. 2012;3(Suppl 3):S198-215. doi: 10.4103/2152-7806.98583. Epub 2012 Jul 17. PMID- 32050354 OWN - NLM STAT- MEDLINE DCOM- 20200319 LR - 20200319 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 244 DP - 2020 Apr TI - Degradation of orange II by Fe@Fe(2)O(3) core shell nanomaterials assisted by NaHSO(3). PG - 125588 LID - S0045-6535(19)32828-0 [pii] LID - 10.1016/j.chemosphere.2019.125588 [doi] AB - Fe@Fe(2)O(3) core shell nanomaterials with different Fe(2)O(3) shell thickness were synthesized and the Fe@Fe(2)O(3)/NaHSO(3) Fenton-like system was used for the decomposition of Orange II. The consequences are compared with traditional Fenton Fe@Fe(2)O(3)/H(2)O(2) system. The Fe@Fe(2)O(3)/NaHSO(3) system showed extremely good applicability under both strongly acidic and alkaline conditions. The new Fe@Fe(2)O(3)-(2)/NaHSO(3) system led to more than 99% degradation in 30 s when the pH was 3, which indicated that the Fe@Fe(2)O(3) material was not corroded during the process even under strongly acidic condition. The above Fe@Fe(2)O(3)-(2) material was prepared from nano-zero-valent iron aged in solution for 2 h to synthesize the Fe(2)O(3) shell. The reaction mechanism of Fe@Fe(2)O(3)/NaHSO(3) Fenton-like system was also concluded. The oxidation efficiency was highly improved due to rapid electron transfer between Fe core and Fe(2)O(3) shell, which promoted the direct recycling of ≡Fe(3+) and ≡Fe(2+) and thus accelerated the generation of SO(4)(-) and OH radicals. CI - Copyright © 2019 Elsevier Ltd. All rights reserved. FAU - Yang, Yan AU - Yang Y AD - School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, Guangdong, China; Synergy Innovation Institute of GDUT, Shantou, 515041, Guangdong, China. Electronic address: yangyan1209@gdut.edu.cn. FAU - Sun, Mengying AU - Sun M AD - School of Environmental and Safety Engineering, Changzhou University, Jiangsu, 213164, China. FAU - Zhou, Jin AU - Zhou J AD - School of Environmental and Safety Engineering, Changzhou University, Jiangsu, 213164, China. FAU - Ma, Jianfeng AU - Ma J AD - School of Environmental and Safety Engineering, Changzhou University, Jiangsu, 213164, China. FAU - Komarneni, Sridhar AU - Komarneni S AD - Department of Ecosystem Science and Management and Materials Research Institute, 204 Energy and the Environment Laboratory, The Pennsylvania State University, University Park, PA, 16802, USA. Electronic address: sxk7@psu.edu. LA - eng PT - Journal Article DEP - 20191209 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Azo Compounds) RN - 0 (Benzenesulfonates) RN - 0 (Sulfites) RN - 91829-63-9 (sodium hydrogen sulfite) RN - BBX060AN9V (Hydrogen Peroxide) RN - E1UOL152H7 (Iron) RN - Q1LIY3BO0U (2-naphthol orange) SB - IM MH - Azo Compounds/*chemistry MH - Benzenesulfonates/*chemistry MH - Hydrogen Peroxide/chemistry MH - Iron/chemistry MH - *Models, Chemical MH - Nanostructures/*chemistry MH - Oxidation-Reduction MH - Sulfites OTO - NOTNLM OT - Bisulfite OT - Core shell nanomaterials OT - Fe@Fe(2)O(3) OT - Rapid electron transfer EDAT- 2020/02/14 06:00 MHDA- 2020/03/20 06:00 CRDT- 2020/02/14 06:00 PHST- 2019/10/23 00:00 [received] PHST- 2019/12/03 00:00 [revised] PHST- 2019/12/08 00:00 [accepted] PHST- 2020/02/14 06:00 [entrez] PHST- 2020/02/14 06:00 [pubmed] PHST- 2020/03/20 06:00 [medline] AID - S0045-6535(19)32828-0 [pii] AID - 10.1016/j.chemosphere.2019.125588 [doi] PST - ppublish SO - Chemosphere. 2020 Apr;244:125588. doi: 10.1016/j.chemosphere.2019.125588. Epub 2019 Dec 9. PMID- 34899316 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231108 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 12 DP - 2021 TI - An Overview of Systematic Reviews of Chinese Herbal Medicine for Alzheimer's Disease. PG - 761661 LID - 10.3389/fphar.2021.761661 [doi] LID - 761661 AB - Background: Multiple systematic reviews (SRs) have been conducted to evaluate the efficacy and safety of Chinese herbal medicine (CHM) in patients with Alzheimer's disease (AD). Here, we aim to perform an overview to assess the methodological quality and quality of evidence of the SRs to provide convincing data on the treatment of AD with CHM. Method: Six electronic databases including Chinese and English were searched, until April 31, 2021. Two researchers independently screen documents and extract data according to the predesigned rules. A Measure Tool to Assessment System Reviews 2 (AMSTAR-2) was used to investigate the methodological quality, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) was used to determine the quality of evidence for outcomes. Results: Twelve qualified SRs including 163 randomized controlled trials were reviewed. The methodological quality of the included SRs was considered extremely low assessed through AMSTAR-2. Compared with western medicines (WM) alone, CHM as an adjuvant treatment has shown significant effects in improving Mini-mental State Examination, Alzheimer's Disease Assessment Scale-Cognitive, and Clinical Dementia Rating scores. The same is true for CHM alone. Regarding the effect on Activities Daily Living, neither the single CHM nor the combination with WM has an obvious effect. For the total effective rate, both single CHM and the combination with WM shown significant effects. Nine SRs suggested that CHM as adjuvant therapy or single-use had fewer adverse events than WM. Additionally, the quality of evidence for the main outcome was reviewed as low or extremely low according to GRADE profiler data. Conclusion: Current evidence suggests that CHM may be beneficial in improving the cognitive function of AD patients. However, we should be cautious about the evidence due to methodological flaws and low quality. High-quality RCTs are further needed to confirm the efficacy and safety of CHM for AD. CI - Copyright © 2021 Liu, Zhang, Sun, Yao, Ma, Fu and Li. FAU - Liu, Nanyang AU - Liu N AD - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Zhang, Tingting AU - Zhang T AD - College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. FAU - Sun, Jiahui AU - Sun J AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. FAU - Yao, Jiuxiu AU - Yao J AD - College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. FAU - Ma, Lina AU - Ma L AD - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Fu, Jianhua AU - Fu J AD - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. FAU - Li, Hao AU - Li H AD - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China. AD - Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China. LA - eng PT - Journal Article PT - Review DEP - 20211126 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC8664324 OTO - NOTNLM OT - Alzheimer’s disease OT - Chinese herbal medicine OT - overview OT - systematic review and meta-analysis OT - traditional Chinese medicine COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/12/14 06:00 MHDA- 2021/12/14 06:01 PMCR- 2021/11/26 CRDT- 2021/12/13 17:53 PHST- 2021/08/20 00:00 [received] PHST- 2021/11/12 00:00 [accepted] PHST- 2021/12/13 17:53 [entrez] PHST- 2021/12/14 06:00 [pubmed] PHST- 2021/12/14 06:01 [medline] PHST- 2021/11/26 00:00 [pmc-release] AID - 761661 [pii] AID - 10.3389/fphar.2021.761661 [doi] PST - epublish SO - Front Pharmacol. 2021 Nov 26;12:761661. doi: 10.3389/fphar.2021.761661. eCollection 2021. PMID- 35071804 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220430 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 8 IP - 1 DP - 2022 Jan TI - Mental health status of married women during COVID-19 pandemic in Bangladesh: A cross-sectional study. PG - e08785 LID - 10.1016/j.heliyon.2022.e08785 [doi] LID - e08785 AB - AIM: The uncontrolled spread of COVID-19 has demanded unparalleled measures, from the imposition of quarantine to the declaration as a public health emergency of international concern. COVID-19 poses a severe threat to our day-to-day life as well as physical and mental health. This study explores mental health status among married women that remain understudied in Bangladesh during the COVID-19 pandemic. METHODOLOGY: A cross-sectional study was conducted among 597 married women via face-to-face interview, maintaining all safety protocols. A semi-structured questionnaire was assembled that included socio-demographics and the DASS-21 scale. Descriptive analysis and logistic regression were performed to examine the associations between variables. RESULT: Almost 35% of the respondents had stress, 20% had anxiety, and 44% had depression ranging from mild to extremely severe. Metropolitan city inhabitants, being housewives, higher educational status, number of children, financial condition, comorbidities, family members assistance in household activities, relocation during COVID-19, social media use, concern about family, infected family members, tendency to get COVID-19 updates had been found significant in multivariable and univariate regression analysis with depression, anxiety, and stress. CONCLUSION: In this study, we found high rates of stress, anxiety, and depression among the study participants. These findings provide us with an epidemiological picture of the mental health status of our target population that could be a key benchmark for identifying high-risk groups and developing policies as well. Results could also be used to formulate psychological interventions that might be helpful during the COVID-19 period and later. CI - © 2022 The Authors. FAU - Sagar, Soumik Kha AU - Sagar SK AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, 1212, Bangladesh. AD - Department of Public Health, North South University, Dhaka, 1229, Bangladesh. AD - Public Health Professional Development Society (PPDS). FAU - Nusrat, Farhana AU - Nusrat F AD - Sherpur Sadar Hospital, Sherpur, Mymensingh, 2100, Bangladesh. FAU - Rashid, Md Utba AU - Rashid MU AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, 1212, Bangladesh. AD - Department of Public Health, North South University, Dhaka, 1229, Bangladesh. FAU - Ghosh, Prakash AU - Ghosh P AD - Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka, 1212, Bangladesh. FAU - Sultana, Maisha AU - Sultana M AD - Sylhet MAG Osmani Medical College, Medical Road, Kajolshah, Sylhet, 3100, Bangladesh. FAU - Ahsan, Alvee AU - Ahsan A AD - Mymensingh Medical College, Chorpara, Mymensingh, 2200, Bangladesh. FAU - Pinky, Susmita Dey AU - Pinky SD AD - Chattogram Medical College Hospital, Panchlaish, Chattogram, 4203, Bangladesh. FAU - Mahboob, Raisa Nawal AU - Mahboob RN AD - Mymensingh Medical College, Chorpara, Mymensingh, 2200, Bangladesh. FAU - Nayon, Sajibur Rahman AU - Nayon SR AD - Sylhet MAG Osmani Medical College, Medical Road, Kajolshah, Sylhet, 3100, Bangladesh. FAU - Shariful Islam, Sheikh Mohammed AU - Shariful Islam SM AD - Public Health Professional Development Society (PPDS). FAU - Hossain Hawlader, Mohammad Delwer AU - Hossain Hawlader MD AD - Department of Public Health, North South University, Dhaka, 1229, Bangladesh. LA - eng PT - Journal Article DEP - 20220119 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC8768011 OTO - NOTNLM OT - Bangladesh OT - COVID-19 OT - DASS-21 OT - Married women OT - Mental health COIS- The authors declare no conflict of interest. EDAT- 2022/01/25 06:00 MHDA- 2022/01/25 06:01 PMCR- 2022/01/19 CRDT- 2022/01/24 08:57 PHST- 2021/07/02 00:00 [received] PHST- 2021/07/25 00:00 [revised] PHST- 2022/01/14 00:00 [accepted] PHST- 2022/01/25 06:00 [pubmed] PHST- 2022/01/25 06:01 [medline] PHST- 2022/01/24 08:57 [entrez] PHST- 2022/01/19 00:00 [pmc-release] AID - S2405-8440(22)00073-1 [pii] AID - e08785 [pii] AID - 10.1016/j.heliyon.2022.e08785 [doi] PST - ppublish SO - Heliyon. 2022 Jan;8(1):e08785. doi: 10.1016/j.heliyon.2022.e08785. Epub 2022 Jan 19. PMID- 38787111 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250107 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 12 IP - 5 DP - 2024 Apr 30 TI - A Human Skin Explant Test as a Novel In Vitro Assay for the Detection of Skin Sensitization to Aggregated Monoclonal Antibodies. LID - 10.3390/toxics12050332 [doi] LID - 332 AB - Introduction: Monoclonal antibodies (mAbs) are important therapeutics. However, the enhanced potential for aggregation has become a critical quality parameter during the production of mAbs. Furthermore, mAb aggregation may also present a potential health risk in a clinical setting during the administration of mAb therapeutics to patients. While the extent of immunotoxicity in patient populations is uncertain, reports show it can lead to immune responses via cell activation and cytokine release. In this study, an autologous in vitro skin test designed to predict adverse immune events, including skin sensitization, was used as a novel assay for the assessment of immunotoxicity caused by mAb aggregation. Material and Methods: Aggregation of mAbs was induced by a heat stress protocol, followed by characterization of protein content by analytical ultra-centrifugation and transmission electron microscopy, revealing a 4% aggregation level of total protein content. Immunotoxicity and potential skin sensitization caused by the aggregates, were then tested in a skin explant assay. Results: Aggregated Herceptin and Rituximab caused skin sensitization, as shown by histopathological damage (grade II-III positive response) together with positive staining for Heat Shock Protein 70 (HSP70). Changes in T cell proliferation were not observed. Cytokine analysis revealed a significant increase of IL-10 for the most extreme condition of aggregation (65 °C at pH3) and a trend for an overall increase of IFN-γ, especially in response to Rituximab. Conclusions: The skin explant assay demonstrated that aggregated mAbs showed adverse immune reactions, as demonstrated as skin sensitization, with histopathological grades II-III. The assay may, therefore, be a novel tool for assessing immunotoxicity and skin sensitization caused by mAb aggregation. FAU - Martins-Ribeiro, Ana AU - Martins-Ribeiro A AD - Alcyomics Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne NE4 5BX, UK. AD - Translational and Clinical Research Institute Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK. FAU - Kizhedath, Arathi AU - Kizhedath A AUID- ORCID: 0000-0002-6939-6416 AD - Chemical Engineering and Advanced Materials, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK. FAU - Ahmed, Shaheda Sameena AU - Ahmed SS AD - Alcyomics Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne NE4 5BX, UK. FAU - Glassey, Jarka AU - Glassey J AD - Chemical Engineering and Advanced Materials, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK. FAU - Ishaq, Abbas AU - Ishaq A AD - Alcyomics Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne NE4 5BX, UK. FAU - Freer, Matthew AU - Freer M AD - Alcyomics Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne NE4 5BX, UK. FAU - Dickinson, Anne Mary AU - Dickinson AM AD - Alcyomics Ltd., The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne NE4 5BX, UK. AD - Translational and Clinical Research Institute Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK. LA - eng GR - 643056/European Commission/ PT - Journal Article DEP - 20240430 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC11125788 OTO - NOTNLM OT - T-cell proliferation OT - cell death OT - immunotoxicity OT - in vitro test OT - mAb aggregation OT - safety assessment OT - skin explant OT - skin sensitization COIS- Ana Martins-Ribeiro, Shaheda Sameena Ahmed, Abbas Ishaq, Matthew Freer, and Anne Mary Dickinson all were employed by Alcyomics Ltd. None of the authors has received or expects to receive research grants from funding agencies. None of the authors has received support from commercial sources of funding by companies that sell drugs, medical devices, or provide medical services. None of the authors has received honoraria for speaking at symposia associated with this work. None of the authors holds a position on advisory board associated with this work. EDAT- 2024/05/24 12:44 MHDA- 2024/05/24 12:45 PMCR- 2024/04/30 CRDT- 2024/05/24 09:34 PHST- 2024/01/09 00:00 [received] PHST- 2024/04/07 00:00 [revised] PHST- 2024/04/22 00:00 [accepted] PHST- 2024/05/24 12:45 [medline] PHST- 2024/05/24 12:44 [pubmed] PHST- 2024/05/24 09:34 [entrez] PHST- 2024/04/30 00:00 [pmc-release] AID - toxics12050332 [pii] AID - toxics-12-00332 [pii] AID - 10.3390/toxics12050332 [doi] PST - epublish SO - Toxics. 2024 Apr 30;12(5):332. doi: 10.3390/toxics12050332. PMID- 37332984 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230620 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 14 DP - 2023 TI - Aging in multiple sclerosis: from childhood to old age, etiopathogenesis, and unmet needs: a narrative review. PG - 1207617 LID - 10.3389/fneur.2023.1207617 [doi] LID - 1207617 AB - Multiple sclerosis (MS) primarily affects adult females. However, in the last decades, rising incidence and prevalence have been observed for demographic extremes, such as pediatric-onset MS (POMS; occurring before 18 years of age) and late-onset MS (corresponding to an onset above 50 years). These categories show peculiar clinical-pathogenetic characteristics, aging processes and disease courses, therapeutic options, and unmet needs. Nonetheless, several open questions are still pending. POMS patients display an important contribution of multiple genetic and environmental factors such as EBV, while in LOMS, hormonal changes and pollution may represent disease triggers. In both categories, immunosenescence emerges as a pathogenic driver of the disease, particularly for LOMS. In both populations, patient and caregiver engagement are essential from the diagnosis communication to early treatment of disease-modifying therapy (DMTs), which in the elderly population appears more complex and less proven in terms of efficacy and safety. Digital technologies (e.g., exergames and e-training) have recently emerged with promising results, particularly in treating and following motor and cognitive deficits. However, this offer seems more feasible for POMS, being LOMS less familiar with digital technology. In this narrative review, we discuss how the aging process influences the pathogenesis, disease course, and therapeutic options of both POMS and LOMS. Finally, we evaluate the impact of new digital communication tools, which greatly interest the current and future management of POMS and LOMS patients. CI - Copyright © 2023 Capasso, Virgilio, Covelli, Giovannini, Foschi, Montini, Nasello, Nilo, Prestipino, Schirò, Sperandei, Clerico and Lanzillo. FAU - Capasso, Nicola AU - Capasso N AD - Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy. AD - Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy. FAU - Virgilio, Eleonora AU - Virgilio E AD - Neurology Unit, Department of Translational Medicine, AOU Maggiore della Carità Novara, University of Eastern Piedmont, Novara, Italy. FAU - Covelli, Antonio AU - Covelli A AD - Department of Neurology, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy. FAU - Giovannini, Beatrice AU - Giovannini B AD - Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. FAU - Foschi, Matteo AU - Foschi M AD - Department of Neuroscience, MS Center, S. Maria delle Croci Hospital, AUSL Romagna, Ravenna, Italy. AD - Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, L'Aquila, Italy. FAU - Montini, Federico AU - Montini F AD - Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy. FAU - Nasello, Martina AU - Nasello M AD - Neurology Unit, Department of Neurosciences, Mental Health and Sensory organs (NESMOS), Sapienza University of Rome, Rome, Italy. FAU - Nilo, Annacarmen AU - Nilo A AD - Clinical Neurology Unit, Department of Head, Neck and Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy. FAU - Prestipino, Elio AU - Prestipino E AD - UOSC Neuro-Stroke Unit, AORN Antonio Cardarelli, Naples, Italy. FAU - Schirò, Giuseppe AU - Schirò G AD - Section of Neurology, Department of Biomedicine, Neurosciences and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy. FAU - Sperandei, Silvia AU - Sperandei S AD - Section of Neurology, Department of Medicine and Surgery, University of Perugia, Perugia, Italy. FAU - Clerico, Marinella AU - Clerico M AD - Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. FAU - Lanzillo, Roberta AU - Lanzillo R AD - Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples, Naples, Italy. AD - Multiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy. LA - eng PT - Journal Article PT - Review DEP - 20230602 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC10272733 OTO - NOTNLM OT - aging OT - engagement OT - immunosenescence OT - late-onset OT - multiple sclerosis OT - pediatric-onset OT - risk factors OT - unmet need COIS- RL and MC received financial compensation for attendance to expert meetings as part of an educational programme by Merck Serono S.p.A., Rome, Italy, an affiliate of Merck. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/06/19 06:42 MHDA- 2023/06/19 06:43 PMCR- 2023/06/02 CRDT- 2023/06/19 02:43 PHST- 2023/04/17 00:00 [received] PHST- 2023/05/15 00:00 [accepted] PHST- 2023/06/19 06:43 [medline] PHST- 2023/06/19 06:42 [pubmed] PHST- 2023/06/19 02:43 [entrez] PHST- 2023/06/02 00:00 [pmc-release] AID - 10.3389/fneur.2023.1207617 [doi] PST - epublish SO - Front Neurol. 2023 Jun 2;14:1207617. doi: 10.3389/fneur.2023.1207617. eCollection 2023. PMID- 38823210 OWN - NLM STAT- MEDLINE DCOM- 20240609 LR - 20240609 IS - 1872-9126 (Electronic) IS - 0003-6870 (Linking) VI - 119 DP - 2024 Sep TI - Influence of floor inclination on handle push and pull forces production of the upper limb. PG - 104322 LID - S0003-6870(24)00099-1 [pii] LID - 10.1016/j.apergo.2024.104322 [doi] AB - Floor inclination can alter hand force production, and lower limb kinetics, affecting control operations, and threatening operator safety in various domains, such as aviation, naval, construction industry, or agriculture. This study investigates the effects of different floor inclinations, on handle push or pull force production. Participants performed maximal isometric contraction tasks requiring to exert a maximal voluntary force either by pulling or pushing a handle, at different floor inclinations from -30° to +30° about the transverse and longitudinal axes. Maximal hand force and Ground Reaction Forces about both feet were recorded. The results revealed non-equivalent variations in hand and feet responses as a function of inclination angle. Specifically, there was a significant reduction in handle push-pull force production, up to 70% (p < 0.001) for extreme inclinations, around both axes. This study provides critical data for design engineers, highlighting the challenge of production forces at steep angles. CI - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Abautret, Matthieu AU - Abautret M AD - Aix-Marseille Univ, CNRS, ISM, 163 Luminy Avenue, 13288 Marseille, Cedex 09, France; Naval Group, 199 Pierre-Gilles De Gennes Avenue, 83190 Ollioules, France. Electronic address: matthieu.abautret@univ-amu.fr. FAU - Monsabert, Benjamin Goislard De AU - Monsabert BG AD - Aix-Marseille Univ, CNRS, ISM, 163 Luminy Avenue, 13288 Marseille, Cedex 09, France. FAU - Maïs, Chantal AU - Maïs C AD - Naval Group, 199 Pierre-Gilles De Gennes Avenue, 83190 Ollioules, France. FAU - Rao, Guillaume AU - Rao G AD - Aix-Marseille Univ, CNRS, ISM, 163 Luminy Avenue, 13288 Marseille, Cedex 09, France. LA - eng PT - Journal Article DEP - 20240531 PL - England TA - Appl Ergon JT - Applied ergonomics JID - 0261412 SB - IM MH - Humans MH - Male MH - Biomechanical Phenomena MH - Adult MH - *Isometric Contraction/physiology MH - *Upper Extremity/physiology MH - Young Adult MH - *Floors and Floorcoverings MH - Female MH - Ergonomics MH - Task Performance and Analysis MH - Hand/physiology MH - Foot/physiology MH - Equipment Design MH - Hand Strength/physiology OTO - NOTNLM OT - Ground reaction force OT - Isometric contraction OT - Man-machine systems OT - Muscle strength OT - Postural balance OT - Working conditions COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This work was financially supported by the ANR as part of the France Relance plan of the French government, in collaboration with Naval Group (France). However, the authors do not derive any commercial benefit from this work. EDAT- 2024/06/02 00:43 MHDA- 2024/06/10 00:42 CRDT- 2024/06/01 18:08 PHST- 2023/10/30 00:00 [received] PHST- 2024/05/21 00:00 [revised] PHST- 2024/05/23 00:00 [accepted] PHST- 2024/06/10 00:42 [medline] PHST- 2024/06/02 00:43 [pubmed] PHST- 2024/06/01 18:08 [entrez] AID - S0003-6870(24)00099-1 [pii] AID - 10.1016/j.apergo.2024.104322 [doi] PST - ppublish SO - Appl Ergon. 2024 Sep;119:104322. doi: 10.1016/j.apergo.2024.104322. Epub 2024 May 31. PMID- 39773399 OWN - NLM STAT- Publisher LR - 20250108 IS - 2211-4599 (Print) IS - 2211-4599 (Linking) DP - 2025 Jan 7 TI - Lateral Transpsoas Interbody Fusion. LID - 8711 [pii] LID - 10.14444/8711 [doi] AB - The lateral transpsoas approach to lumbar interbody fusion has gained widespread adoption for a variety of indications. This approach to the interbody space allows for a favorable fusion environment, disc and neuroforaminal height restoration, and powerful alignment correction. Despite its minimally invasive nature, this procedure carries unique risks, the most severe of which include bowel injury, major vascular injury, and lumbosacral plexopathy. This poses a marked learning curve and requires rigorous attention to detail in technique. In this review, we provide a detailed description of our approach to preoperative imaging, patient positioning, and surgical technique, with an emphasis on patient safety and evidence-based decision-making. A brief description of intraoperative neuromonitoring techniques follows. The lateral transpsoas approach to interbody fusion has demonstrated reliable outcomes in regard to fusion rates, pain and function, and deformity correction, all across a widespread variety of lumbar spine pathologies. Here, we depict techniques, pearls, and pitfalls that are critical for any surgeon considering whether to add this technique to their practice. CI - This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2025 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com. FAU - Sullivan, T Barrett AU - Sullivan TB AD - Department of Orthopedic Surgery, University of California San Diego, La Jolla, CA, USA tbsullivan@health.ucsd.edu. FAU - Ordaz, Angel AU - Ordaz A AD - Department of Orthopedic Surgery, University of California San Diego, La Jolla, CA, USA. FAU - Phillips, Frank M AU - Phillips FM AD - Ronald DeWald Endowed Professor of Spinal Deformities, Rush University Medical Center, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20250107 PL - Netherlands TA - Int J Spine Surg JT - International journal of spine surgery JID - 101579005 OTO - NOTNLM OT - XLIF OT - degenerative disease OT - extreme lateral interbody fusion OT - low back pain OT - lumbar interbody fusion OT - minimally invasive spine surgery COIS- Declaration of Conflicting Interests : The authors report no conflicts of interest in this work. EDAT- 2025/01/08 18:21 MHDA- 2025/01/08 18:21 CRDT- 2025/01/08 15:13 PHST- 2025/01/08 18:21 [medline] PHST- 2025/01/08 18:21 [pubmed] PHST- 2025/01/08 15:13 [entrez] AID - 8711 [pii] AID - 10.14444/8711 [doi] PST - aheadofprint SO - Int J Spine Surg. 2025 Jan 7:8711. doi: 10.14444/8711. PMID- 33171682 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201114 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 13 IP - 21 DP - 2020 Nov 8 TI - Effect of a Boric Acid Corrosive Environment on the Microstructure and Properties of Concrete. LID - 10.3390/ma13215036 [doi] LID - 5036 AB - Boric acid, a weak acid, is often used to shield neutrons in water cooling systems in nuclear power stations. The leakage of boric acid in water cooling systems damages the concrete structure and affects the safety of nuclear power engineering. In this experiment, concrete specimens were cured with boric acid at 20, 40, and 70 °C to study the effect of boric acid on the microstructure and properties of concrete. X-ray diffraction (XRD) and thermogravimetry and differential scanning calorimetry (TG-DSC) were used to analyze the change in mineral composition. The microstructure was examined by scanning electron microscope (SEM). The porosity of the concrete was examined by mercury intrusion porosimetry (MIP). The results show that the performance of specimens was stable under the curing conditions of 20 and 40 °C. Under the curing environment of 70 °C, the performance of concrete cured with 0, 2000, and 7000 ppm concentrations was stable, but the compressive strength of the 180,000 ppm specimen was reduced by 27.8% and suffered the most serious loss of mass and surface corrosion, with the most harmful pores. The high concentration of boric acid seriously damaged the surface structure of concrete, which is the main reason for its loss of properties. This situation is extremely dangerous in nuclear power engineering, so the effect of boric acid leakage cannot be ignored. FAU - Wang, Yu AU - Wang Y AUID- ORCID: 0000-0002-5000-8962 AD - College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China. AD - State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China. FAU - Huang, Bei AU - Huang B AD - College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China. AD - State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China. FAU - Mao, Zhongyang AU - Mao Z AD - College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China. AD - State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China. FAU - Deng, Min AU - Deng M AD - College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China. AD - State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China. FAU - Cao, Huan AU - Cao H AD - College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211800, China. AD - State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211800, China. LA - eng GR - 51608265/National Natural Science Foundation of China/ PT - Journal Article DEP - 20201108 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC7664702 OTO - NOTNLM OT - boric acid OT - concrete durability OT - microstructure OT - nuclear safety OT - properties COIS- The authors declare no conflict of interest. EDAT- 2020/11/12 06:00 MHDA- 2020/11/12 06:01 PMCR- 2020/11/08 CRDT- 2020/11/11 01:01 PHST- 2020/10/07 00:00 [received] PHST- 2020/11/01 00:00 [revised] PHST- 2020/11/04 00:00 [accepted] PHST- 2020/11/11 01:01 [entrez] PHST- 2020/11/12 06:00 [pubmed] PHST- 2020/11/12 06:01 [medline] PHST- 2020/11/08 00:00 [pmc-release] AID - ma13215036 [pii] AID - materials-13-05036 [pii] AID - 10.3390/ma13215036 [doi] PST - epublish SO - Materials (Basel). 2020 Nov 8;13(21):5036. doi: 10.3390/ma13215036. PMID- 2957207 OWN - NLM STAT- MEDLINE DCOM- 19871022 LR - 20141120 IS - 0140-1610 (Print) IS - 0140-1610 (Linking) VI - 8 IP - 1 DP - 1987 TI - Non-steroidal anti-inflammatory drugs: assessment of risks. PG - 71-85 AB - The prescription-event monitoring procedure developed at the University of Southampton was used to evaluate five different non-steroidal anti-inflammatory drugs (NSAIDs), including piroxicam, in approximately 55,000 patients. The overall incidence of side effects was what would be expected. The risks of gastrointestinal haemorrhage and peptic ulceration were spread uniformly across the five drugs under study. No real difference was seen in the incidence of these conditions when patients discontinued the medication or switched to another NSAID. Overall, serious side effects were extremely rare. One provocative finding was the possibility that drugs of this class may exert a cardioprotective effect. There appeared to be a deficit of cases of myocardial infarction while the patients were taking an NSAID. Responsibility for the efficacy and safety of all drugs resides with many people and organizations: the manufacturers, national health departments, licensing departments, and physicians. The press, which has contributed to many unwarranted panics concerning drug safety, also must refrain from using power without responsibility. FAU - Inman, W H AU - Inman WH LA - eng PT - Journal Article PL - England TA - Eur J Rheumatol Inflamm JT - European journal of rheumatology and inflammation JID - 7805765 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 0 (Propionates) RN - 17SZX404IM (benoxaprofen) RN - XXE1CET956 (Indomethacin) SB - IM MH - Adult MH - Aged MH - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects MH - Cardiovascular Diseases/chemically induced MH - Central Nervous System Diseases/chemically induced MH - Drug Eruptions/etiology MH - Female MH - Gastrointestinal Diseases/chemically induced MH - Humans MH - Indomethacin/adverse effects MH - Jaundice/chemically induced MH - Male MH - Middle Aged MH - Propionates/adverse effects MH - Risk EDAT- 1987/01/01 00:00 MHDA- 1987/01/01 00:01 CRDT- 1987/01/01 00:00 PHST- 1987/01/01 00:00 [pubmed] PHST- 1987/01/01 00:01 [medline] PHST- 1987/01/01 00:00 [entrez] PST - ppublish SO - Eur J Rheumatol Inflamm. 1987;8(1):71-85. PMID- 30960045 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 2073-4360 (Electronic) IS - 2073-4360 (Linking) VI - 11 IP - 1 DP - 2019 Jan 4 TI - The Effect of the Surface Area of Carbon Black Grades on HNBR in Harsh Environments. LID - 10.3390/polym11010061 [doi] LID - 61 AB - Concerning the still rising demand for oil and gas products, the development of new reliable materials to guarantee the facility safety at extreme operating conditions is an utmost necessity. The present study mainly deals with the influence of different carbon black (CB) filled hydrogenated nitrile butadiene rubber (HNBR), which is a material usually used in sealing applications, on the rapid gas decompression (RGD) resistance in harsh environments. Therefore, RGD component level tests were conducted in an autoclave. The supporting mechanical and dynamic mechanical property analysis, the microscopic level investigations on the material and failure analysis were conducted and are discussed in this work. Under the tested conditions, the samples filled with smaller CB primary particles showed a slightly lower volume increase during the compression and decompression phases; however, they steered to a significantly lower resistance to RGD. Transmission electron micrographs revealed that the samples filled with smaller CB particles formed larger structures as well as densified filler networks including larger agglomerates and as a consequence a decrease effective matrix component around the CB particles. Apparently, at higher loading conditions, which already deliver a certain level of mechanical stresses and strains, the densified filler network, and especially a lower amount of effective matrix material composition, adversely affect the RGD resistance. SEM-based fracture analysis did not identify any influence of the CB grades tested on the crack initiation site; however, it revealed that the cracks initiated from existing voids, hard particles, or low strength matrix sites and propagated to the outer surface. FAU - Balasooriya, Winoj AU - Balasooriya W AD - Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, 8700 Leoben, Austria. Winoj.Balasooriya@pccl.at. FAU - Schrittesser, Bernd AU - Schrittesser B AUID- ORCID: 0000-0002-8756-6634 AD - Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, 8700 Leoben, Austria. Bernd.Schrittesser@pccl.at. FAU - Pinter, Gerald AU - Pinter G AD - Department of Polymer Engineering and Science, Montanuniversitaet Leoben, Otto Glöckeltrasse 2, 8700 Leoben, Austria. Gerald.Pinter@unileoben.ac.at. FAU - Schwarz, Thomas AU - Schwarz T AD - SKF Sealing Solutions Austria GmbH, Gabelhoferstrasse 25, 8750 Judenburg, Austria. Thomas.Schwarz@skf.com. FAU - Conzatti, Lucia AU - Conzatti L AUID- ORCID: 0000-0003-1899-8262 AD - National Research Council, ISMAC Genova, Via De Marini 6, 16149 Genova, Italy. Lucia.Conzatti@ge.ismac.cnr.it. LA - eng GR - 854178/Österreichische Forschungsförderungsgesellschaft/ PT - Journal Article DEP - 20190104 PL - Switzerland TA - Polymers (Basel) JT - Polymers JID - 101545357 PMC - PMC6401997 OTO - NOTNLM OT - HNBR OT - carbon black OT - elastomers OT - oil and gas OT - rapid gas decompression COIS- The authors declare no conflict of interest. EDAT- 2019/04/10 06:00 MHDA- 2019/04/10 06:01 PMCR- 2019/01/04 CRDT- 2019/04/10 06:00 PHST- 2018/12/05 00:00 [received] PHST- 2018/12/18 00:00 [revised] PHST- 2018/12/28 00:00 [accepted] PHST- 2019/04/10 06:00 [entrez] PHST- 2019/04/10 06:00 [pubmed] PHST- 2019/04/10 06:01 [medline] PHST- 2019/01/04 00:00 [pmc-release] AID - polym11010061 [pii] AID - polymers-11-00061 [pii] AID - 10.3390/polym11010061 [doi] PST - epublish SO - Polymers (Basel). 2019 Jan 4;11(1):61. doi: 10.3390/polym11010061. PMID- 32783289 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201217 LR - 20201217 IS - 1521-3773 (Electronic) IS - 1433-7851 (Linking) VI - 59 IP - 48 DP - 2020 Nov 23 TI - A Robust Mixed-Lanthanide PolyMOF Membrane for Ratiometric Temperature Sensing. PG - 21752-21757 LID - 10.1002/anie.202009765 [doi] AB - Temperature sensors play a significant role in biology, chemistry, and engineering, especially those that can work accurately in a noninvasive manner. We adopted a photoinduced post-synthetic copolymerization strategy to realize a membranous ratiometric luminescent thermometer based on the emissions of two lanthanide ions. This novel mixed-lanthanide polyMOF membrane exhibits not only the integrity and temperature sensing behaviour of the Ln-MOF powder but also excellent mechanical properties, such as flexibility, elasticity, and processability. Moreover, the polyMOF membrane shows remarkable stability under harsh conditions, including high humidity, strong acid and alkali (pH 0-14), which allowed the mapping of temperature distributions in extreme circumstances. This work highlights a simple strategy for polyMOF membrane formation and pushes forward the further practical application of Ln-MOF-based luminescent thermometers in various fields and conditions. CI - © 2020 Wiley-VCH GmbH. FAU - Feng, Tongtong AU - Feng T AD - Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China. FAU - Ye, Yingxiang AU - Ye Y AD - Department of Chemistry, University of Texas at San Antonio, San Antonio, TX, 78249, USA. FAU - Liu, Xiao AU - Liu X AD - Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China. FAU - Cui, Hui AU - Cui H AD - Department of Chemistry, University of Texas at San Antonio, San Antonio, TX, 78249, USA. FAU - Li, Zhiqiang AU - Li Z AD - Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China. FAU - Zhang, Ying AU - Zhang Y AD - Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China. FAU - Liang, Bin AU - Liang B AD - Department of Chemistry, University of Texas at San Antonio, San Antonio, TX, 78249, USA. FAU - Li, Huanrong AU - Li H AD - Tianjin Key Laboratory of Chemical Process Safety, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, 300130, P. R. China. FAU - Chen, Banglin AU - Chen B AUID- ORCID: 0000-0001-8707-8115 AD - Department of Chemistry, University of Texas at San Antonio, San Antonio, TX, 78249, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200921 PL - Germany TA - Angew Chem Int Ed Engl JT - Angewandte Chemie (International ed. in English) JID - 0370543 SB - IM OTO - NOTNLM OT - copolymerization OT - lanthanides OT - membranes OT - metal-organic frameworks OT - ratiometric thermometers EDAT- 2020/08/13 06:00 MHDA- 2020/08/13 06:01 CRDT- 2020/08/13 06:00 PHST- 2020/07/15 00:00 [received] PHST- 2020/08/08 00:00 [revised] PHST- 2020/08/13 06:00 [pubmed] PHST- 2020/08/13 06:01 [medline] PHST- 2020/08/13 06:00 [entrez] AID - 10.1002/anie.202009765 [doi] PST - ppublish SO - Angew Chem Int Ed Engl. 2020 Nov 23;59(48):21752-21757. doi: 10.1002/anie.202009765. Epub 2020 Sep 21. PMID- 9575408 OWN - NLM STAT- MEDLINE DCOM- 19980729 LR - 20121115 IS - 0869-2092 (Print) IS - 0869-2092 (Linking) VI - 61 IP - 1 DP - 1998 Jan-Feb TI - [The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions]. PG - 30-2 AB - Administration of 0.05 g gidazepam once or twice daily for 7 days increased the stroke volume (SV) and circulation volume (CV) and reduced total peripheral resistance in neurotic patients. In healthy individuals 0.05 g gidazepam administered 60 min before an important examination stabilized CV. In subjects kept for 60 min in a microclimate with increasing temperature (55 +/- 2 degrees C, relative humidity 75-80%, rate of movement 1.5 m/min, rectal temperature at the end of exposure 39 degrees C) 0.05 g gidazepam administered 60 min before overheating optimally reorganized the reaction of the cardiovascular system, stabilized the SV at the initial level, which together with the growing heart rate increased the CV and provided sufficient perfusion of the vital organs. In healthy subjects working as operators for 4 h under conditions of hypercapnia (1.5% CO2), a single administration of 0.05 g gidazepam one hour before the beginning of work reduced the pulse pressure and increased the SV. The results obtained are evidence of the safety of using gidazepam as a corrector of emotion-induced disorders in operator performance under extreme conditions. FAU - Morozov, I S AU - Morozov IS AD - Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. FAU - Barchukov, V G AU - Barchukov VG FAU - Neznamov, G G AU - Neznamov GG LA - rus PT - Comparative Study PT - English Abstract PT - Journal Article TT - Vliianie gidazepama na funktsional'noe sostoianie serdechno-sosudistoĭ sistemy bol'nykh s nevroticheskimi reaktsiiami i u zdorovykh lits v oslozhnennykh usloviiakh. PL - Russia (Federation) TA - Eksp Klin Farmakol JT - Eksperimental'naia i klinicheskaia farmakologiia JID - 9215981 RN - 0 (Anti-Anxiety Agents) RN - 0 (Benzodiazepinones) RN - 0 (Cardiotonic Agents) RN - 12794-10-4 (Benzodiazepines) RN - XMJ87I93Y9 (gidazepam) SB - IM MH - Adolescent MH - Adult MH - Anti-Anxiety Agents/administration & dosage/*pharmacology MH - *Benzodiazepines MH - Benzodiazepinones/administration & dosage/*pharmacology MH - Cardiotonic Agents/administration & dosage/*pharmacology MH - Cardiovascular System/*drug effects/physiopathology MH - Drug Evaluation MH - Female MH - Humans MH - Male MH - Neurotic Disorders/*drug therapy/physiopathology/psychology MH - Psychophysiology MH - Reference Values MH - Time Factors EDAT- 1998/05/12 00:00 MHDA- 1998/05/12 00:01 CRDT- 1998/05/12 00:00 PHST- 1998/05/12 00:00 [pubmed] PHST- 1998/05/12 00:01 [medline] PHST- 1998/05/12 00:00 [entrez] PST - ppublish SO - Eksp Klin Farmakol. 1998 Jan-Feb;61(1):30-2. PMID- 34714682 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230403 IS - 2375-2548 (Electronic) IS - 2375-2548 (Linking) VI - 7 IP - 44 DP - 2021 Oct 29 TI - Computational modeling investigation of pulsed high peak power microwaves and the potential for traumatic brain injury. PG - eabd8405 LID - 10.1126/sciadv.abd8405 [doi] LID - eabd8405 AB - When considering safety standards for human exposure to radiofrequency (RF) and microwave energy, the dominant concerns pertain to a thermal effect. However, in the case of high-power pulsed RF/microwave energy, a rapid thermal expansion can lead to stress waves within the body. In this study, a computational model is used to estimate the temperature profile in the human brain resulting from exposure to various RF/microwave incident field parameters. The temperatures are subsequently used to simulate the resulting mechanical response of the brain. Our simulations show that, for certain extremely high-power microwave exposures (permissible by current safety standards), very high stresses may occur within the brain that may have implications for neuropathological effects. Although the required power densities are orders of magnitude larger than most real-world exposure conditions, they can be achieved with devices meant to emit high-power electromagnetic pulses in military and research applications. FAU - Dagro, Amy M AU - Dagro AM AUID- ORCID: 0000-0002-3250-3732 AD - U.S. Army Research Laboratory, Aberdeen Proving Ground, MD 21005, USA. FAU - Wilkerson, Justin W AU - Wilkerson JW AUID- ORCID: 0000-0001-9754-1409 AD - J. Mike '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USA. FAU - Thomas, Thaddeus P AU - Thomas TP AD - U.S. Army Research Laboratory, Aberdeen Proving Ground, MD 21005, USA. FAU - Kalinosky, Benjamin T AU - Kalinosky BT AD - General Dynamics Information Technology, JBSA Fort Sam Houston, San Antonio, TX 78234, USA. FAU - Payne, Jason A AU - Payne JA AUID- ORCID: 0000-0003-4262-1596 AD - Air Force Research Laboratory, 711th Human Performance Wing, Airman Systems Directorate, Bioeffects Division, Radio Frequency Bioeffects Branch, JBSA Fort Sam Houston, San Antonio, TX 78234, USA. LA - eng PT - Journal Article DEP - 20211029 PL - United States TA - Sci Adv JT - Science advances JID - 101653440 SB - IM PMC - PMC8555891 EDAT- 2021/10/30 06:00 MHDA- 2021/10/30 06:01 PMCR- 2021/10/29 CRDT- 2021/10/29 17:10 PHST- 2021/10/29 17:10 [entrez] PHST- 2021/10/30 06:00 [pubmed] PHST- 2021/10/30 06:01 [medline] PHST- 2021/10/29 00:00 [pmc-release] AID - abd8405 [pii] AID - 10.1126/sciadv.abd8405 [doi] PST - ppublish SO - Sci Adv. 2021 Oct 29;7(44):eabd8405. doi: 10.1126/sciadv.abd8405. Epub 2021 Oct 29. PMID- 38705628 OWN - NLM STAT- MEDLINE DCOM- 20240505 LR - 20240505 IS - 0091-679X (Print) IS - 0091-679X (Linking) VI - 187 DP - 2024 TI - Laboratory based correlative cryo-soft X-ray tomography and cryo-fluorescence microscopy. PG - 293-320 LID - S0091-679X(24)00064-5 [pii] LID - 10.1016/bs.mcb.2024.02.033 [doi] AB - Cryo-soft X-ray tomography is the unique technology that can image whole intact cells in 3D under normal and pathological conditions without labelling or fixation, at high throughput and spatial resolution. The sample preparation is relatively straightforward; requiring just fast freezing of the specimen before transfer to the microscope for imaging. It is also possible to image chemically fixed samples where necessary. The technique can be correlated with cryo fluorescence microscopy to localize fluorescent proteins to organelles within the whole cell volume. Cryo-correlated light and soft X-ray tomography is particularly useful for the study of gross morphological changes brought about by disease or drugs. For example, viral fluorescent tags can be co-localized to sites of viral replication in the soft X-ray volume. In general this approach is extremely useful in the study of complex 3D organelle structure, nanoparticle uptake or in the detection of rare events in the context of whole cell structure. The main challenge of soft X-ray tomography is that the soft X-ray illumination required for imaging has heretofore only been available at a small number of synchrotron labs worldwide. Recently, a compact device with a footprint small enough to fit in a standard laboratory setting has been deployed ("the SXT-100") and is routinely imaging cryo prepared samples addressing a variety of disease and drug research applications. The SXT-100 facilitates greater access to this powerful technique and greatly increases the scope and throughput of potential research projects. Furthermore, the availability of cryo-soft X-ray tomography in the laboratory will accelerate the development of novel correlative and multimodal workflows by integration with light and electron microscope based approaches. It also allows for co-location of this powerful imaging modality at BSL3 labs or other facilities where safety or intellectual property considerations are paramount. Here we describe the compact SXT-100 microscope along with its novel integrated cryo-fluorescence imaging capability. CI - Copyright © 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. FAU - Fahy, Kenneth AU - Fahy K AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. Electronic address: kenneth.fahy@siriusxt.com. FAU - Kapishnikov, Sergey AU - Kapishnikov S AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. FAU - Donnellan, Martina AU - Donnellan M AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. FAU - McEnroe, Tony AU - McEnroe T AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. FAU - O'Reilly, Fergal AU - O'Reilly F AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland; University College Dublin, School of Physics, Dublin, Ireland; University College Dublin, School of Biology and Environmental Sciences, Dublin, Ireland. FAU - Fyans, William AU - Fyans W AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. FAU - Sheridan, Paul AU - Sheridan P AD - SiriusXT Ltd., Stillorgan Industrial Park, Dublin, Ireland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20240322 PL - United States TA - Methods Cell Biol JT - Methods in cell biology JID - 0373334 SB - IM MH - *Microscopy, Fluorescence/methods MH - *Tomography, X-Ray/methods MH - Humans MH - Imaging, Three-Dimensional/methods MH - Animals MH - Cryopreservation/methods OTO - NOTNLM OT - Cell biology OT - Correlative and multimodal imaging OT - Disease research OT - Drug research OT - Soft X-ray microscopy OT - Structural imaging OT - Tomography OT - Whole cell imaging EDAT- 2024/05/06 00:52 MHDA- 2024/05/06 00:53 CRDT- 2024/05/05 20:58 PHST- 2024/05/06 00:53 [medline] PHST- 2024/05/06 00:52 [pubmed] PHST- 2024/05/05 20:58 [entrez] AID - S0091-679X(24)00064-5 [pii] AID - 10.1016/bs.mcb.2024.02.033 [doi] PST - ppublish SO - Methods Cell Biol. 2024;187:293-320. doi: 10.1016/bs.mcb.2024.02.033. Epub 2024 Mar 22. PMID- 34197293 OWN - NLM STAT- MEDLINE DCOM- 20210707 LR - 20210707 IS - 1929-6355 (Electronic) IS - 1910-622X (Linking) VI - 34 IP - 2 DP - 2021 Jun TI - An Academic Health Sciences Centre's Strategy to Enhance Nurse Resilience and Psychological Safety. PG - 39-44 LID - cjnl.2021.26531 [pii] LID - 10.12927/cjnl.2021.26531 [doi] AB - The rapid cadence of change and the fear of acquiring and spreading COVID-19 - coupled with moral distress exacerbated by fulfilling one's duty to care under extremely challenging conditions - continue to impact nurses' coping ability, resilience and psychological safety globally (McDougall et al. 2020). This paper provides an overview of how an academic health sciences centre (AHSC) has responded to the evolving waves of the COVID-19 pandemic. Specifically, we share our context and the strategies we used to build and enhance nurse resilience and psychological safety at the organizational, clinical team and individual levels. This is followed by a description of our nurses' achievements amid the pandemic. CI - Copyright © 2021 Longwoods Publishing. FAU - Jeffs, Lianne AU - Jeffs L AD - Research and Innovation Lead Scholar in Residence, Nursing and Health Disciplines, Senior Clinician Scientist, Lunenfeld-Tanenbaum Research, Sinai Health, Associate Professor, Bloomberg Faculty of Nursing, Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, ON. FAU - Merkley, Jane AU - Merkley J AD - Executive Vice President, Chief Nurse, Executive and Chief Operating Officer, Sinai Health, Toronto, ON. FAU - Greenberg, Rebecca AU - Greenberg R AD - Senior Bioethicist, Sinai Health, Associate Professor, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON. FAU - Ginty, Leanne AU - Ginty L AD - Director, Professional Practice, Nursing, Sinai Health, Toronto, ON. FAU - Amaral, Nely AU - Amaral N AD - Director, Nursing, Quality and Performance, Magnet Program Director, Sinai Health, Toronto, ON. FAU - Maunder, Robert AU - Maunder R AD - Chair in Health and Behaviour, Deputy Psychiatrist-in-Chief and Head of Psychiatry Research, Sinai Health, Professor, Department of Psychiatry, University of Toronto, Toronto, ON. FAU - Wiesenfeld, Lesley AU - Wiesenfeld L AD - Psychiatrist-in-Chief Head, Geriatric Psychiatry Consultation, Liaison Service, Sinai Health, Associate Professor, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON. FAU - Brown, Susan AU - Brown S AD - Executive Vice President, People & Culture, Chief Human Resources Officer, Sinai Health, Toronto, ON. FAU - Shing, Paula AU - Shing P AD - Interim Director, Professional Practice and Education, Nursing and Health Disciplines, Sinai Health, Toronto, ON. FAU - Ronald, Kara AU - Ronald K AD - Vice President, Professional Practice, Nursing and Health Disciplines, Sinai Health, Toronto, ON. LA - eng PT - Journal Article PL - Canada TA - Nurs Leadersh (Tor Ont) JT - Nursing leadership (Toronto, Ont.) JID - 101470760 MH - Academic Medical Centers/organization & administration MH - *Adaptation, Psychological MH - COVID-19/epidemiology/*nursing MH - Humans MH - Leadership MH - Nursing Staff, Hospital/*organization & administration/psychology MH - Pandemics MH - Patient Care Team/organization & administration MH - *Resilience, Psychological MH - SARS-CoV-2 EDAT- 2021/07/02 06:00 MHDA- 2021/07/08 06:00 CRDT- 2021/07/01 17:17 PHST- 2021/07/01 17:17 [entrez] PHST- 2021/07/02 06:00 [pubmed] PHST- 2021/07/08 06:00 [medline] AID - cjnl.2021.26531 [pii] AID - 10.12927/cjnl.2021.26531 [doi] PST - ppublish SO - Nurs Leadersh (Tor Ont). 2021 Jun;34(2):39-44. doi: 10.12927/cjnl.2021.26531. PMID- 39871799 OWN - NLM STAT- Publisher LR - 20250210 IS - 1521-3773 (Electronic) IS - 1433-7851 (Linking) DP - 2025 Jan 28 TI - Exceptional Battery-level Safety of High Energy Density Lithium-Ion Batteries through Non-Flammable and Low-Exothermic Localize High Concentration Electrolytes. PG - e202423554 LID - 10.1002/anie.202423554 [doi] AB - The poor safety performance of high energy density lithium-ion batteries (LIBs) is drawing increasing public concern. To enhance the safety performance on the battery level, it is indispensable to design safe electrolytes that are both non-flammable and low exothermic under abusive conditions. By rational design, a safe localize high concentration electrolyte (LHCE) with non-flammability and extremely low exothermicity is formulated. Compared with conventional LiPF(6)-organocabonate electrolytes and previous LHCEs, the heat generated by the reaction between the safe LHCE and fully charged electrodes under abusive conditions is significantly reduced. Because of the non-flammability and low-exothermicity of the safe LHCE, high energy density LIB (1800 mAh Gr||LiNi(0.7)Mn(0.2)Co(0.1)O(2), fully charged to 4.3 V) with the safe LHCE successfully passes the nail penetration test. Because of the excellent interphasial properties of the safe LHCE, the cycle life and the rate capability of high energy density LIBs are significantly improved when the safe LHCE is adopted. This work sheds light on the design principles of electrolytes for achieving battery-level safety. CI - © 2025 Wiley-VCH GmbH. FAU - Qiu, Huamin AU - Qiu H AUID- ORCID: 0009-0000-6750-8210 AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Jia, Hao AU - Jia H AUID- ORCID: 0000-0003-2814-5589 AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Zhou, Yifan AU - Zhou Y AUID- ORCID: 0000-0002-6741-1416 AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Wang, Jun AU - Wang J AUID- ORCID: 0000-0001-9561-5857 AD - School of Innovation and Entrepreneurship, Southern University of Science and Technology, Shenzhen, 518055, P. R. China. FAU - Zhao, Wenguang AU - Zhao W AD - School of Advanced Materials, Peking University Shenzhen Graduate School, Shenzhen, 518055, P.R. China. FAU - Xu, Kaiyang AU - Xu K AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Li, Zimu AU - Li Z AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Song, Shuqin AU - Song S AUID- ORCID: 0000-0002-7459-6738 AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. FAU - Wang, Yi AU - Wang Y AD - The Key Lab of Low-carbon Chemistry & Energy Conservation of Guangdong Province, PCMF Laboratory, School of Chemical Engineering and Technology, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, 510275, P. R. China. LA - eng GR - 22408408/National Natural Science Foundation of China/ GR - 22478450/National Natural Science Foundation of China/ GR - 22478451/National Natural Science Foundation of China/ GR - 76110-12230029/100 Top Talents Program of Sun Yat-sen University/ PT - Journal Article DEP - 20250128 PL - Germany TA - Angew Chem Int Ed Engl JT - Angewandte Chemie (International ed. in English) JID - 0370543 SB - IM OTO - NOTNLM OT - battery-level safety OT - high energy density lithium-ion batteries OT - localized high concentration electrolytes OT - low-exothermic OT - non-flammability EDAT- 2025/01/28 11:26 MHDA- 2025/01/28 11:26 CRDT- 2025/01/28 04:42 PHST- 2024/12/03 00:00 [received] PHST- 2025/01/28 11:26 [pubmed] PHST- 2025/01/28 11:26 [medline] PHST- 2025/01/28 04:42 [entrez] AID - 10.1002/anie.202423554 [doi] PST - aheadofprint SO - Angew Chem Int Ed Engl. 2025 Jan 28:e202423554. doi: 10.1002/anie.202423554. PMID- 38289432 OWN - NLM STAT- MEDLINE DCOM- 20241119 LR - 20241122 IS - 1573-5168 (Electronic) IS - 0920-1742 (Print) IS - 0920-1742 (Linking) VI - 50 IP - 5 DP - 2024 Oct TI - Uncommon life history and winter spawning of common carp (Cyprinus carpio) in a natural thermal spring, under temperate climate. PG - 2043-2051 LID - 10.1007/s10695-024-01305-w [doi] AB - Common carp female generally matures at age 4-5 years old and spawns between April and July under the temperate climate. Contrary to a range of 0-28 °C of temperate freshwaters, the water temperature of Lake Hévíz (Hungary, Central Europe), the largest natural bathable thermal lake in the world, varies between 26 and 35 °C seasonally. The specific environmental conditions (continuously warm water and its individual chemical composition, special nutrient base, lack of natural lakeside spawning substrate compared to usual spawning grounds, continuous high human disturbance, etc.) suggest that the carp population here may also differ in reproductive characteristics from their counterparts in surrounding waters. Our findings suggest that the self-sustaining dwarf common carp population of Lake Hévíz matures 2 to 4 years earlier (at the age of one) and spawns 1 to 3 months before (between February and April, at 27-30 °C water temperature) than carp typically do in the temperate zone (16-20 °C). Successful winter spawning was verified by rearing larvae from the collected eggs and in situ induced propagation. CI - © 2024. The Author(s). FAU - Müller, Tamás AU - Müller T AD - Department of Freshwater Fish Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 7400, Gödöllő, Hungary. muller.tamas@uni-mate.hu. FAU - Ferincz, Árpád AU - Ferincz Á AD - Department of Freshwater Fish Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 7400, Gödöllő, Hungary. FAU - Weiperth, András AU - Weiperth A AD - Department of Freshwater Fish Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 7400, Gödöllő, Hungary. AD - Department of Systematic Zoology and Ecology, Institute of Biology, Eötvös Loránd University, 1117, Budapest, Hungary. FAU - Ivánovics, Bence AU - Ivánovics B AD - Department of Environmental Toxicology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 2100, Gödöllő, Hungary. FAU - Tóth, Balázs AU - Tóth B AD - Duna-Ipoly National Park Directorate, 2509, Esztergom, Hungary. FAU - Bógó, Bence AU - Bógó B AD - Department of Freshwater Fish Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 7400, Gödöllő, Hungary. FAU - Horváth, József AU - Horváth J AD - Department of Freshwater Fish Ecology, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 7400, Gödöllő, Hungary. FAU - Urbányi, Béla AU - Urbányi B AD - Department of Aquaculture, Institute of Aquaculture and Environmental Safety, Hungarian University of Agriculture and Life Sciences, 2100, Gödöllő, Hungary. urbanyi.bela@uni-mate.hu. FAU - Specziár, András AU - Specziár A AD - HUN-REN Balaton Limnological Research Institute, 8237, Tihany, Hungary. LA - eng GR - NKFI K - 135824/National Research, Development and Innovation Office/ GR - ÚNKP-23-2-I-MATE-6/National Research, Development and Innovation Office/ GR - FFT NP FTA, NP2022-II3/2022/Sustainable Development and Technologies National Programme of the Hungarian Academy of Sciences/ PT - Journal Article DEP - 20240130 PL - Netherlands TA - Fish Physiol Biochem JT - Fish physiology and biochemistry JID - 100955049 SB - IM MH - Animals MH - *Carps/physiology MH - *Seasons MH - *Reproduction/physiology MH - Female MH - Temperature MH - Climate MH - Male MH - Natural Springs MH - Lakes PMC - PMC11576824 OTO - NOTNLM OT - Breeding season OT - Climate change OT - Dwarfism OT - Extreme habitat OT - Maturity OT - Thermal habitat COIS- Declarations Ethical approval Fish sampling was carried out with the permission of the Ministry of Agriculture (HHgF/457 1/2017; HaGF/113/2019). After propagation and embryo collection, our investigations did not extend beyond the non-feeding stage of the larvae, in accordance with the 2010/63/EU.Directive. Competing interests The authors declare no competing interests. EDAT- 2024/01/30 12:43 MHDA- 2024/11/19 18:22 PMCR- 2024/01/30 CRDT- 2024/01/30 11:08 PHST- 2023/09/03 00:00 [received] PHST- 2024/01/17 00:00 [accepted] PHST- 2024/11/19 18:22 [medline] PHST- 2024/01/30 12:43 [pubmed] PHST- 2024/01/30 11:08 [entrez] PHST- 2024/01/30 00:00 [pmc-release] AID - 10.1007/s10695-024-01305-w [pii] AID - 1305 [pii] AID - 10.1007/s10695-024-01305-w [doi] PST - ppublish SO - Fish Physiol Biochem. 2024 Oct;50(5):2043-2051. doi: 10.1007/s10695-024-01305-w. Epub 2024 Jan 30. PMID- 36748355 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20230223 LR - 20230223 IS - 1744-6848 (Electronic) IS - 1744-683X (Linking) VI - 19 IP - 8 DP - 2023 Feb 22 TI - Stretchable superhydrophobic fluororubber fabricated by transferring mesh microstructures. PG - 1560-1568 LID - 10.1039/d2sm01677j [doi] AB - Stretchable flexible superhydrophobic surfaces are in great demand to achieve waterproofing performance in aerospace, electronic industry, and other fields. However, there are still many challenges in developing superhydrophobic surfaces, which maintain their wetting characteristics under high strain conditions with good tensile durability. Here, we propose a simple and efficient method to prepare a stretchable superhydrophobic fluororubber surface composed of hierarchical micro-convexities, which are orderly arranged and interconnected. Its peculiar structure shows excellent superhydrophobicity (155.48 ± 1.97°) and high water sliding angle due to Cassie's impregnating wetting regime. Due to the special structure and high mechanical strength of the surface, it can still maintain its superhydrophobic property after a variety of durability tests, including various stretching tests, sandpaper abrasion, sand impact, and high-temperature treatment. In addition, the surface can still realize the lossless transfer of water droplets even at large stretching strains, which is expected to be applied to microfluidic devices under extreme working conditions. FAU - Wang, Jiwen AU - Wang J AUID- ORCID: 0000-0001-8573-7869 AD - School of Mechatronics Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China. AD - College of Civil Aviation Safety Engineering, Civil Aviation Flight University of China, Guanghan, Sichuan, 618307, China. AD - Henan Joint International Research Laboratory of Man Machine Environment and Emergency Management, Anyang 455000, Henan, China. aystar@163.com. FAU - Zhang, Yanbin AU - Zhang Y AD - School of Mechatronics Engineering, Henan University of Science and Technology, Luoyang 471003, Henan, China. FAU - He, Qiang AU - He Q AUID- ORCID: 0000-0003-4948-7887 AD - College of Civil Aviation Safety Engineering, Civil Aviation Flight University of China, Guanghan, Sichuan, 618307, China. AD - Henan Joint International Research Laboratory of Man Machine Environment and Emergency Management, Anyang 455000, Henan, China. aystar@163.com. LA - eng PT - Journal Article DEP - 20230222 PL - England TA - Soft Matter JT - Soft matter JID - 101295070 SB - IM EDAT- 2023/02/08 06:00 MHDA- 2023/02/08 06:01 CRDT- 2023/02/07 04:23 PHST- 2023/02/08 06:00 [pubmed] PHST- 2023/02/08 06:01 [medline] PHST- 2023/02/07 04:23 [entrez] AID - 10.1039/d2sm01677j [doi] PST - epublish SO - Soft Matter. 2023 Feb 22;19(8):1560-1568. doi: 10.1039/d2sm01677j. PMID- 30301731 OWN - NLM STAT- MEDLINE DCOM- 20181231 LR - 20201009 IS - 1757-790X (Electronic) IS - 1757-790X (Linking) VI - 2018 DP - 2018 Oct 8 TI - Ascites with hepatic extravasation of total parenteral nutrition (TPN) secondary to umbilical venous catheter (UVC) malposition in an extremely preterm baby. LID - bcr-2018-226377 [pii] LID - 10.1136/bcr-2018-226377 [doi] LID - bcr2018226377 AB - The ease of access and advantages of a secure central line makes use of umbilical venous catheter (UVC) and umbilical artery catheters a part of the standard of care in the extremely premature babies in the neonatal intensive care unit. However, there are complications associated with their use. One of the uncommon complications reported is total parenteral nutrition (TPN) ascites secondary to vessel perforation or hepatic erosion by the tip of the catheter due to malposition of a UVC. We present here a case of such catheter perforation causing ascites and right hepatic collection of TPN in a 28-week-old infant. Abdominal paracentesis was therapeutic by relieving the distension as well as confirming the presence of parenteral nutrition in the peritoneal cavity. CI - © BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Pegu, Satyaranjan AU - Pegu S AUID- ORCID: 0000-0002-7699-9864 AD - Division of Neonatology, Department of Pediatrics, Regina General Hospital, Regina, Saskatchewan, Canada. FAU - Murthy, Poornima AU - Murthy P AD - Division of Neonatology, Department of Pediatrics, Regina General Hospital, Regina, Saskatchewan, Canada. LA - eng PT - Case Reports PT - Journal Article DEP - 20181008 PL - England TA - BMJ Case Rep JT - BMJ case reports JID - 101526291 SB - IM MH - Ascites/*diagnosis/diagnostic imaging/etiology MH - Catheters, Indwelling/*adverse effects MH - Extravasation of Diagnostic and Therapeutic Materials/*diagnosis/diagnostic imaging/etiology MH - Female MH - Humans MH - Iatrogenic Disease MH - Infant MH - *Infant, Extremely Premature MH - Parenteral Nutrition, Total/*adverse effects MH - Tomography, X-Ray Computed MH - *Umbilical Veins PMC - PMC6194449 OTO - NOTNLM OT - healthcare improvement and patient safety OT - neonatal intensive care OT - unwanted effects / adverse reactions COIS- Competing interests: None declared. EDAT- 2018/10/12 06:00 MHDA- 2019/01/01 06:00 PMCR- 2020/10/08 CRDT- 2018/10/11 06:00 PHST- 2018/10/11 06:00 [entrez] PHST- 2018/10/12 06:00 [pubmed] PHST- 2019/01/01 06:00 [medline] PHST- 2020/10/08 00:00 [pmc-release] AID - bcr-2018-226377 [pii] AID - 10.1136/bcr-2018-226377 [doi] PST - epublish SO - BMJ Case Rep. 2018 Oct 8;2018:bcr2018226377. doi: 10.1136/bcr-2018-226377. PMID- 37662159 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230905 IS - 1664-462X (Print) IS - 1664-462X (Electronic) IS - 1664-462X (Linking) VI - 14 DP - 2023 TI - Genes and pathways correlated with heat stress responses and heat tolerance in maize kernels. PG - 1228213 LID - 10.3389/fpls.2023.1228213 [doi] LID - 1228213 AB - Global warming leads to frequent extreme weather, especially the extreme heat events, which threating the safety of maize production. Here we selected a pair of maize inbred lines, PF5411-1 and LH150, with significant differences in heat tolerance at kernel development stage. The two maize inbred lines were treated with heat stress at kernel development stage. Compared with the control groups, transcriptomic analysis identified 770 common up- and down-regulated genes between PF5411-1 and LH150 under heat stress conditions, and 41 putative TFs were predicted. Based on the interaction term of the two-factorial design, we also identified 6,744 differentially regulated genes between LH150 and PF5411-1, 111 common up-regulated and 141 common down-regulated genes were overlapped with the differentially regulated genes, respectively. Combined with proteins and metabolites data, several key pathways including seven differentially regulated genes were highly correlated with the heat tolerance of maize kernels. The first is the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway ko04141: protein processing in endoplasmic reticulum, four small heat shock protein (sHSP) genes were enriched in this pathway, participating with the process of ER-associated degradation (ERAD). The second one is the myricetin biosynthesis pathway, a differentially regulated protein, flavonoid 3',5'-hydroxylase [EC:1.14.14.81], catalyzed the synthesis of myricetin. The third one is the raffinose metabolic pathway, one differentially regulated gene encoded the raffinose synthase controlled the synthesis of raffinose, high level of raffinose enhances the heat tolerance of maize kernels. And the last one is the ethylene signaling pathway. Taken together, our work identifies many genes responded to heat stress in maize kernels, and finds out seven genes and four pathways highly correlated with heat tolerance of maize kernels. CI - Copyright © 2023 Chen, Du, Zhang, Chen, Fu, Li and Yang. FAU - Chen, Yan AU - Chen Y AD - State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. AD - Hainan Yazhou Bay Seed Laboratory, Sanya, China. FAU - Du, Tingting AU - Du T AD - Nanfan Research Institute, Chinese Academy of Agricultural Sciences, Sanya, China. FAU - Zhang, Jie AU - Zhang J AD - State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. FAU - Chen, Shoukun AU - Chen S AD - Hainan Yazhou Bay Seed Laboratory, Sanya, China. FAU - Fu, Junjie AU - Fu J AD - State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. FAU - Li, Huihui AU - Li H AD - State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, China. AD - Nanfan Research Institute, Chinese Academy of Agricultural Sciences, Sanya, China. FAU - Yang, Qin AU - Yang Q AD - Crop Research Institute, Sichuan Academy of Agricultural Sciences, Chengdu, China. LA - eng PT - Journal Article DEP - 20230817 PL - Switzerland TA - Front Plant Sci JT - Frontiers in plant science JID - 101568200 PMC - PMC10470023 OTO - NOTNLM OT - genes OT - heat response OT - heat tolerance OT - maize kernel OT - pathways COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer ZZ declared shared affiliation with the authors YC, TD, JZ, JF, HL to the handling editor at the time of review. EDAT- 2023/09/04 06:42 MHDA- 2023/09/04 06:43 PMCR- 2023/01/01 CRDT- 2023/09/04 04:37 PHST- 2023/05/24 00:00 [received] PHST- 2023/08/01 00:00 [accepted] PHST- 2023/09/04 06:43 [medline] PHST- 2023/09/04 06:42 [pubmed] PHST- 2023/09/04 04:37 [entrez] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fpls.2023.1228213 [doi] PST - epublish SO - Front Plant Sci. 2023 Aug 17;14:1228213. doi: 10.3389/fpls.2023.1228213. eCollection 2023. PMID- 28881244 OWN - NLM STAT- MEDLINE DCOM- 20180202 LR - 20181202 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 188 DP - 2017 Dec TI - Disinfection byproduct precursor dynamics and water treatability during an extreme flooding event in a coastal blackwater river in southeastern United States. PG - 90-98 LID - S0045-6535(17)31346-2 [pii] LID - 10.1016/j.chemosphere.2017.08.122 [doi] AB - Coastal blackwater rivers, characterized by high concentrations of natural organic matter, are source water for millions of people in the southeastern US. In October 2015, large areas of coastal South Carolina were flooded by Hurricane Joaquin. This so-called "thousand-year" rainfall mobilized and flushed large amounts of terrestrial organic matter and associated pollutants (e.g. mercury) into source water, affecting water quality and safety of municipal water supply. To understand the dynamics of water quality and water treatability during this extreme flood, water samples were collected from Waccamaw River (a typical blackwater river in the southeastern US) during rising limb, peak discharge, falling limb, and base flow. Despite decreasing water flow after peak discharge, dissolved organic carbon (DOC) levels (increased by up to 125%), and formation potentials of trihalomethanes and haloacetic acids (increased by up to 150%) remained high for an extended period of time (>eight weeks after peak discharge), while variation in the N-nitrosodimethylamine (NDMA) FP was negligible. Coagulation with alum and ferric at optimal dosage significantly reduced concentrations of DOC by 51-76%, but up to 10 mg/L of DOC still remained in treated waters. For an extended period of time, elevated levels of THMs (71-448 μg/L) and HAAs (88-406 μg/L) were quantified in laboratory chlorination experiments under uniform formation conditions (UFC), exceeding the United States Environmental Protection Agency's (USEPA) maximum contaminant level of 80 and 60 μg/L, respectively. Results demonstrated that populations in coastal cities are at high risk with disinfection by-products (DBPs) under the changing climate. CI - Copyright © 2017 Elsevier Ltd. All rights reserved. FAU - Ruecker, A AU - Ruecker A AD - Biogeochemistry & Environmental Quality Research Group, Clemson University, SC, USA. FAU - Uzun, H AU - Uzun H AD - Department of Environmental Engineering and Earth Sciences, Clemson University, SC, USA. FAU - Karanfil, T AU - Karanfil T AD - Department of Environmental Engineering and Earth Sciences, Clemson University, SC, USA. FAU - Tsui, M T K AU - Tsui MTK AD - Department of Biology, University of North Carolina at Greensboro, Greensboro, NC, USA. FAU - Chow, A T AU - Chow AT AD - Biogeochemistry & Environmental Quality Research Group, Clemson University, SC, USA; Department of Environmental Engineering and Earth Sciences, Clemson University, SC, USA. Electronic address: achow@clemson.edu. LA - eng PT - Journal Article DEP - 20170823 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Trihalomethanes) RN - 0 (Water Pollutants, Chemical) SB - IM MH - *Disinfection MH - *Floods MH - Halogenation MH - Rivers/chemistry MH - South Carolina MH - Southeastern United States MH - Trihalomethanes/analysis MH - United States MH - Water Pollutants, Chemical/*analysis MH - *Water Purification MH - Water Quality/*standards MH - Water Supply/*standards OTO - NOTNLM OT - DOM properties OT - Disinfection byproducts OT - Major flooding OT - Mercury OT - Water quality EDAT- 2017/09/08 06:00 MHDA- 2018/02/03 06:00 CRDT- 2017/09/08 06:00 PHST- 2017/05/10 00:00 [received] PHST- 2017/08/18 00:00 [revised] PHST- 2017/08/22 00:00 [accepted] PHST- 2017/09/08 06:00 [pubmed] PHST- 2018/02/03 06:00 [medline] PHST- 2017/09/08 06:00 [entrez] AID - S0045-6535(17)31346-2 [pii] AID - 10.1016/j.chemosphere.2017.08.122 [doi] PST - ppublish SO - Chemosphere. 2017 Dec;188:90-98. doi: 10.1016/j.chemosphere.2017.08.122. Epub 2017 Aug 23. PMID- 35095828 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 12 DP - 2021 TI - The Potential Role of Microbial Biostimulants in the Amelioration of Climate Change-Associated Abiotic Stresses on Crops. PG - 829099 LID - 10.3389/fmicb.2021.829099 [doi] LID - 829099 AB - Crop plants are more often exposed to abiotic stresses in the current age of fast-evolving climate change. This includes exposure to extreme and unpredictable changes in climatic conditions, phytosanitary hazards, and cultivation conditions, which results in drastic losses in worldwide agricultural productions. Plants coexist with microbial symbionts, some of which play key roles in the ecosystem and plant processes. The application of microbial biostimulants, which take advantage of symbiotic relationships, is a long-term strategy for improving plant productivity and performance, even in the face of climate change-associated stresses. Beneficial filamentous fungi, yeasts, and bacteria are examples of microbial biostimulants, which can boost the growth, yield, nutrition and stress tolerance in plants. This paper highlights recent information about the role of microbial biostimulants and their potential application in mitigating the abiotic stresses occurring on crop plants due to climate change. A critical evaluation for their efficient use under diverse climatic conditions is also made. Currently, accessible products generally improve cultural conditions, but their action mechanisms are mostly unknown, and their benefits are frequently inconsistent. Thus, further studies that could lead to the more precisely targeted products are discussed. CI - Copyright © 2022 Fadiji, Babalola, Santoyo and Perazzolli. FAU - Fadiji, Ayomide Emmanuel AU - Fadiji AE AD - Food Security and Safety Niche, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa. FAU - Babalola, Olubukola Oluranti AU - Babalola OO AD - Food Security and Safety Niche, Faculty of Natural and Agricultural Sciences, North-West University, Potchefstroom, South Africa. FAU - Santoyo, Gustavo AU - Santoyo G AD - Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico. FAU - Perazzolli, Michele AU - Perazzolli M AD - Center Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, Italy. AD - Research and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Italy. LA - eng PT - Journal Article PT - Review DEP - 20220114 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC8795815 OTO - NOTNLM OT - PGPR OT - arbuscular mycorrhizal fungi OT - climate change OT - plant-microbe interaction OT - sustainable agriculture COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/02/01 06:00 MHDA- 2022/02/01 06:01 PMCR- 2022/01/14 CRDT- 2022/01/31 05:56 PHST- 2021/12/04 00:00 [received] PHST- 2021/12/29 00:00 [accepted] PHST- 2022/01/31 05:56 [entrez] PHST- 2022/02/01 06:00 [pubmed] PHST- 2022/02/01 06:01 [medline] PHST- 2022/01/14 00:00 [pmc-release] AID - 10.3389/fmicb.2021.829099 [doi] PST - epublish SO - Front Microbiol. 2022 Jan 14;12:829099. doi: 10.3389/fmicb.2021.829099. eCollection 2021. PMID- 32287360 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200928 IS - 1434-0860 (Electronic) IS - 0015-7899 (Print) IS - 0015-7899 (Linking) VI - 68 IP - 4 DP - 2004 TI - A rate equation approach to model the denaturation or replication behavior of the SARS coronavirus. PG - 227-238 LID - 10.1007/s10010-004-0130-2 [doi] AB - As a newly emerging virus, little is known about the SARS coronavirus, whose outbreak has brought away several hundred people's lives over the world in the year of 2003 and is seriously imperiling the human health. Revealing the denaturation and replication mechanisms of SARS coronavirus has great importance for successfully fighting SARS. However, experiments related to SARS coronavirus are extremely dangerous and therefore restricted only to certain specific labs with high safety standard. Clearly, predicting the behaviors of SARS coronavirus in a wide variety of environmental conditions, which are not easily accessible, are thus critically necessary. In this study, we proposed to quantify the survival time of SARS coronavirus either in vitro or in vivo, through introducing thermal rate process models established from the well-known Arrhenius law. The complex physical and chemical behaviors of the SARS coronavirus can then be attributed to its activation energy, frequency factor, damage function as well as the surrounding environmental conditions. Based on the first data on stability and resistance of SARS coronavirus measured by members of WHO laboratory network, the rate coefficients involved in the above equations were estimated for the first time. Predictions on the survival time of SARS coronavirus in different temperature scale were then performed. It was found theoretically that, such survival time falls in an extremely wide range, say from several seconds in high temperature to an almost infinitely long time in a low temperature environment, which has already or is being supported by the currently available tests data. Applications of the present theory to interpret several existing phenomena were presented and their implementations in developing new technical ways for SARS prevention and clinical therapy were discussed. Uncertainties involved in the theoretical models were also analyzed and predicted. Parametric studies were performed to test the effects of the rate coefficients to the survival time of SARS coronavirus. Some important factors, which can significantly vary the denaturation or replication process of SARS coronavirus were pointed out. Through regulating the parameters involved in the equation, certain potential therapies either through drug delivery or engineering approach to treat the SARS disease can possibly be established. Extension of the present model for further studies was also suggested. This study opens a new theoretical way for probing into the complex behaviors of SARS coronavirus. Modellierung der Denaturierung oder Repliziryng von SARS-Korona-Viren Zusammenfassung Der Kenntnisstand über die Eigenschaften des in 2003 neu aufgetretenen SARS Korona Virus, der einige Hundert Menschenleben gekostet hat, ist relativ gering. Die Ermittlung des Denaturierungs- und Replizierungsmechanismuses des SARS Virus ist für seine Bekämpfung von hoher Bedeutung. Experimentelle Untersuchungen an diesem extrem gefährlichen Virus dürfen nur durch Laboratorien mit einem hohen Sicherheitsstandard erfolgen. Die Vorhersage des Verhaltens des SARS Virus in unterschiedlichen Umgebungsbedingungen ist dabei erforderlich. In der vorliegenden Studie wird die überlebensdauer des Virus unter Labor- und realen Bedingungen durch Anwendung der bekannten Arrhenius-Beziehung für temperaturabhängige Vorgänge ermittelt. Das physikalische und chemische Verhalten des SARS Virus wird anhand der zugrundeliegenden Modell- Parameter beschrieben. Basierend auf den ersten Messungen von Mitgliedern des WHO-laboratory-network über die Stabilität und Widerstandsfähigkeit des Virus wurden erstmalig die Geschwindigkeitskoeffizienten des Berechnungsmodells bestimmt. Vorhersagen der Überlebensdauer des SARS-Virus unter unterschiedlichen Temperaturbedingungen wurden ausgeführt. Das sich hieraus ergebende, sehr unterschiedliche Ausmaß der Überlebensfähigkeit in Abhängigkeit der Umgebungstemperatur ist durch den Vergleich mit verfügbaren experimentellen Ergebnissen bestätigt worden. Die Anwendung der vorgestellten Modellierung zur Interpretation realer Phänomene und zur Entwicklung technischer Maßnahmen zur Vorbeugung und klinischen Therapierung von SARS wird diskutiert. Der Einfluß von Unsicherheiten des Modells wird analysiert und abgeschätzt. Parametrische Studien sind durchgeführt worden, um den Einfluß der Geschwindigkeitskoeffizienten auf die Überlebensdauer des SARS Virus darzustellen. Einige wichtige Einflußgrößen auf die Denaturierung und Replikationsfähigkeit des SARS Virus werden aufgezeigt. Durch eine Variation der Modellparameter kann die potentielle Wirksamkeit medikamentöser oder physikalischer Therapien abgeschätzt werden. Erweiterungsmöglichkeiten des vorgestellten Modells werden vorgeschlagen. Die vorliegende Studie ermöglicht neue, theoretische Vorgehensweisen zur Untersuchung des komplexen Verhaltensmusters des SARS Virus. CI - © Springer-Verlag Berlin Heidelberg 2004. FAU - Liu, J AU - Liu J AD - Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Cryogenics Lab, 2711, 100080 Beijing, People's Republic of China. GRID: grid.458502.e. ISNI: 0000 0004 0644 7196 LA - eng PT - Journal Article PL - Germany TA - Forsch Ingenieurwes JT - Forschung im ingenieurwesen JID - 101765249 PMC - PMC7111653 OTO - NOTNLM OT - Damage Function OT - Laboratory Network OT - Rate Coefficient OT - Replication Mechanism OT - Survival Time EDAT- 2004/01/01 00:00 MHDA- 2004/01/01 00:01 PMCR- 2020/04/01 CRDT- 2020/04/15 06:00 PHST- 2020/04/15 06:00 [entrez] PHST- 2004/01/01 00:00 [pubmed] PHST- 2004/01/01 00:01 [medline] PHST- 2020/04/01 00:00 [pmc-release] AID - 130 [pii] AID - 10.1007/s10010-004-0130-2 [doi] PST - ppublish SO - Forsch Ingenieurwes. 2004;68(4):227-238. doi: 10.1007/s10010-004-0130-2. PMID- 33567438 OWN - NLM STAT- MEDLINE DCOM- 20210831 LR - 20210831 IS - 1661-7819 (Electronic) IS - 1661-7800 (Linking) VI - 118 IP - 1 DP - 2021 TI - The Risk of Necrotizing Enterocolitis following the Administration of Hyperosmolar Enteral Medications to Extremely Preterm Infants. PG - 73-79 LID - 10.1159/000513169 [doi] AB - INTRODUCTION: Necrotizing enterocolitis (NEC) is a disease predominantly affecting preterm infants. The administration of hyperosmolar solutions could lead to the development of NEC. The objective of this study was to measure the osmolality of enteral medications used in clinical practice and to assess the risk of NEC following exposure to hyperosmolar medications. METHODS: A retrospective cohort study in extremely preterm infants (gestational age <28 weeks) born between 2010 and 2016 at a tertiary neonatal intensive care unit in Sweden. 465 infants were identified via the Swedish Neonatal Quality register. Data relating to enteral administrations received during a two-week period were collected from the medical records. The osmolalities of medications were measured using an osmometer. Logistic regression was used to calculate the odds ratio of developing NEC. RESULTS: A total of 253 patients met the inclusion criteria. The osmolalities of 5 commonly used medications significantly exceeded the recommended limit of 450 mOsm/kg set by the American Academy of Paediatrics (AAP). Most patients (94%) received at least one hyperosmolar medication. No significant risk of developing NEC could be found. CONCLUSION: The medications used in clinical practice can significantly exceed the limit set by the AAP. This study does not indicate an increased risk of developing NEC in extremely preterm infants following exposure to hyperosmolar medications. Further studies in larger cohorts are needed to determine the specific cut-off level of osmolality in relation to the pathogenesis of NEC. CI - © 2021 The Author(s). Published by S. Karger AG, Basel. FAU - Latheef, Faiza AU - Latheef F AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden, faiza.latheef@regionvastmanland.se. AD - Department of Hospital Pharmacy, Region Västmanland, Västerås, Sweden, faiza.latheef@regionvastmanland.se. FAU - Wahlgren, Hanna AU - Wahlgren H AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Lilja, Helene Engstrand AU - Lilja HE AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Diderholm, Barbro AU - Diderholm B AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Paulsson, Mattias AU - Paulsson M AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210210 PL - Switzerland TA - Neonatology JT - Neonatology JID - 101286577 SB - IM MH - Child MH - *Enterocolitis, Necrotizing/chemically induced/epidemiology MH - Humans MH - Infant MH - Infant, Extremely Premature MH - Infant, Newborn MH - *Infant, Premature, Diseases/chemically induced/epidemiology MH - Intensive Care Units, Neonatal MH - Retrospective Studies OTO - NOTNLM OT - Extremely preterm infant OT - Necrotizing enterocolitis OT - Oral medication OT - Osmolality OT - Safety EDAT- 2021/02/11 06:00 MHDA- 2021/09/01 06:00 CRDT- 2021/02/10 20:09 PHST- 2020/06/23 00:00 [received] PHST- 2020/11/10 00:00 [accepted] PHST- 2021/02/11 06:00 [pubmed] PHST- 2021/09/01 06:00 [medline] PHST- 2021/02/10 20:09 [entrez] AID - 000513169 [pii] AID - 10.1159/000513169 [doi] PST - ppublish SO - Neonatology. 2021;118(1):73-79. doi: 10.1159/000513169. Epub 2021 Feb 10. PMID- 26337116 OWN - NLM STAT- MEDLINE DCOM- 20160912 LR - 20151123 IS - 1873-2607 (Electronic) IS - 0749-3797 (Linking) VI - 49 IP - 6 Suppl 4 DP - 2015 Dec TI - Vaccine Hesitancy: Causes, Consequences, and a Call to Action. PG - S391-8 LID - S0749-3797(15)00314-1 [pii] LID - 10.1016/j.amepre.2015.06.009 [doi] AB - Vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. There is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. Although vaccination is a norm in the U.S. and the majority of parents vaccinate their children, many do so amid concerns. The proportion of parents claiming non-medical exemptions to school immunization requirements has been increasing over the past decade. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pertussis, resulting in the unnecessary suffering of young children and waste of limited public health resources. Vaccine hesitancy is an extremely important issue that needs to be addressed because effective control of vaccine-preventable diseases generally requires indefinite maintenance of extremely high rates of timely vaccination. The multifactorial and complex causes of vaccine hesitancy require a broad range of approaches on the individual, provider, health system, and national levels. These include standardized measurement tools to quantify and locate clustering of vaccine hesitancy and better understand issues of trust; rapid, independent, and transparent review of an enhanced and appropriately funded vaccine safety system; adequate reimbursement for vaccine risk communication in doctors' offices; and individually tailored messages for parents who have vaccine concerns, especially first-time pregnant women. The potential of vaccines to prevent illness and save lives has never been greater. Yet, that potential is directly dependent on parental acceptance of vaccines, which requires confidence in vaccines, healthcare providers who recommend and administer vaccines, and the systems to make sure vaccines are safe. CI - Copyright © 2015 by American Journal of Preventive Medicine and Elsevier Ltd. Published by Elsevier Inc. All rights reserved. FAU - Salmon, Daniel A AU - Salmon DA AD - Departments of International Health and Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Electronic address: dsalmon1@jhu.edu. FAU - Dudley, Matthew Z AU - Dudley MZ AD - Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Glanz, Jason M AU - Glanz JM AD - Institute for Health Research, Kaiser Permanente Colorado, Denver, Colorado; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado. FAU - Omer, Saad B AU - Omer SB AD - Rollins School of Public Health, Emory University, Atlanta, Georgia. LA - eng PT - Journal Article DEP - 20150831 PL - Netherlands TA - Am J Prev Med JT - American journal of preventive medicine JID - 8704773 RN - 0 (Vaccines) SB - IM MH - Consumer Health Information MH - Disease Outbreaks/*prevention & control MH - Health Knowledge, Attitudes, Practice MH - Health Personnel MH - Humans MH - Parents/*psychology MH - Risk Assessment MH - Treatment Refusal/*psychology MH - United States MH - Vaccines/*administration & dosage EDAT- 2015/09/05 06:00 MHDA- 2016/09/13 06:00 CRDT- 2015/09/05 06:00 PHST- 2015/03/04 00:00 [received] PHST- 2015/06/03 00:00 [revised] PHST- 2015/06/17 00:00 [accepted] PHST- 2015/09/05 06:00 [entrez] PHST- 2015/09/05 06:00 [pubmed] PHST- 2016/09/13 06:00 [medline] AID - S0749-3797(15)00314-1 [pii] AID - 10.1016/j.amepre.2015.06.009 [doi] PST - ppublish SO - Am J Prev Med. 2015 Dec;49(6 Suppl 4):S391-8. doi: 10.1016/j.amepre.2015.06.009. Epub 2015 Aug 31. PMID- 33316132 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20220731 IS - 1461-0248 (Electronic) IS - 1461-023X (Print) IS - 1461-023X (Linking) VI - 24 IP - 3 DP - 2021 Mar TI - Diverging functional strategies but high sensitivity to an extreme drought in tropical dry forests. PG - 451-463 LID - 10.1111/ele.13659 [doi] AB - Extreme drought events have negative effects on forest diversity and functioning. At the species level, however, these effects are still unclear, as species vary in their response to drought through specific functional trait combinations. We used long-term demographic records of 21,821 trees and extensive databases of traits to understand the responses of 338 tropical dry forests tree species to ENSO(2015) , the driest event in decades in Northern South America. Functional differences between species were related to the hydraulic safety-efficiency trade-off, but unexpectedly, dominant species were characterised by high investment in leaf and wood tissues regardless of their leaf phenological habit. Despite broad functional trait combinations, tree mortality was more widespread in the functional space than tree growth, where less adapted species showed more negative net biomass balances. Our results suggest that if dry conditions increase in this ecosystem, ecological functionality and biomass gain would be reduced. CI - © 2020 The Authors. Ecology Letters published by John Wiley & Sons Ltd. FAU - González-M, Roy AU - González-M R AUID- ORCID: 0000-0002-4346-998X AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. AD - Department of Biology, Faculty of Natural Sciences, Universidad del Rosario, Cr. 24 # 63C-69, Bogotá, Colombia. FAU - Posada, Juan M AU - Posada JM AUID- ORCID: 0000-0001-7794-9300 AD - Department of Biology, Faculty of Natural Sciences, Universidad del Rosario, Cr. 24 # 63C-69, Bogotá, Colombia. FAU - Carmona, Carlos P AU - Carmona CP AUID- ORCID: 0000-0001-6935-4913 AD - Institute of Ecology and Earth Sciences, University of Tartu, Lai 40, Tartu, 51005, Estonia. FAU - Garzón, Fabián AU - Garzón F AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Salinas, Viviana AU - Salinas V AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Idárraga-Piedrahita, Álvaro AU - Idárraga-Piedrahita Á AD - Fundación Jardín Botánico de Medellín, Herbario "Joaquín Antonio Uribe" (JAUM), Cll. 73 # 51D-14, Medellín, Colombia. FAU - Pizano, Camila AU - Pizano C AUID- ORCID: 0000-0003-4124-1348 AD - Departamento de Biología, Facultad de Ciencias Naturales, Universidad Icesi, Cll. 18 # 122-135 Pance, Cali, Colombia. FAU - Avella, Andrés AU - Avella A AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. AD - Facultad del Medio Ambiente y Recursos Naturales, Universidad Distrital Francisco José de Caldas, Cr. 5 Este # 15-82, Bogotá, Colombia. FAU - López-Camacho, René AU - López-Camacho R AUID- ORCID: 0000-0003-2026-0371 AD - Facultad del Medio Ambiente y Recursos Naturales, Universidad Distrital Francisco José de Caldas, Cr. 5 Este # 15-82, Bogotá, Colombia. FAU - Norden, Natalia AU - Norden N AUID- ORCID: 0000-0001-5207-312X AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Nieto, Jhon AU - Nieto J AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Medina, Sandra P AU - Medina SP AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Rodríguez-M, Gina M AU - Rodríguez-M GM AD - Fundación Ecosistemas Secos de Colombia, Cll. 5A, Bogotá, # 70C-31, Colombia. FAU - Franke-Ante, Rebeca AU - Franke-Ante R AD - Dirección Territorial Caribe, Parques Nacionales Naturales de Colombia, Cll. 17 # 4-06, Santa Marta, Colombia. FAU - Torres, Alba M AU - Torres AM AD - Departamento de Biología, Facultad de Ciencias, Universidad de Valle, Cll. 13 # 100-00, Cali, Colombia. FAU - Jurado, Rubén AU - Jurado R AD - Asociación GAICA, Cll. 11A # 32-21, Pasto, Colombia. FAU - Cuadros, Hermes AU - Cuadros H AD - Programa de Biología, Universidad del Atlántico, Km. 7 vía Puerto, Barranquilla, Colombia. FAU - Castaño-Naranjo, Alejandro AU - Castaño-Naranjo A AD - Jardín Botánico del Valle del Cauca Juan María Céspedes - INCIVA, Cra. 27 #31-47, Tuluá, Colombia. FAU - García, Hernando AU - García H AD - Programa Ciencias Básicas de la Biodiversidad, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Cr. 1 # 16-20, Bogotá, Colombia. FAU - Salgado-Negret, Beatriz AU - Salgado-Negret B AUID- ORCID: 0000-0002-3103-9878 AD - Departamento de Biología, Universidad Nacional de Colombia, Bogotá, Colombia. LA - eng GR - ATN/BD-15408-CO/Interamerican Development Bank/ GR - PSG293/Eesti Teadusagentuur/ GR - PSG293/International Tropical Timber Organization/ GR - Estonian Research Council/ GR - European Regional Development Fund/ GR - University of Tartu/ GR - COLCIENCIAS/ PT - Letter DEP - 20201214 PL - England TA - Ecol Lett JT - Ecology letters JID - 101121949 RN - 059QF0KO0R (Water) SB - IM MH - *Droughts MH - Ecosystem MH - Forests MH - North America MH - Plant Leaves MH - Trees MH - *Tropical Climate MH - Water PMC - PMC9292319 OTO - NOTNLM OT - Biomass OT - demographic rates OT - hydraulic safety-efficiency trade-off OT - investment in tissues OT - trait probability density EDAT- 2020/12/15 06:00 MHDA- 2021/02/16 06:00 PMCR- 2022/07/18 CRDT- 2020/12/14 17:16 PHST- 2020/04/29 00:00 [received] PHST- 2020/09/09 00:00 [revised] PHST- 2020/11/15 00:00 [accepted] PHST- 2020/12/15 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2020/12/14 17:16 [entrez] PHST- 2022/07/18 00:00 [pmc-release] AID - ELE13659 [pii] AID - 10.1111/ele.13659 [doi] PST - ppublish SO - Ecol Lett. 2021 Mar;24(3):451-463. doi: 10.1111/ele.13659. Epub 2020 Dec 14. PMID- 30363649 OWN - NLM STAT- MEDLINE DCOM- 20190204 LR - 20190215 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2018 DP - 2018 TI - Stability of Bacteriocin-Like Inhibitory Substance (BLIS) Produced by Pediococcus acidilactici kp10 at Different Extreme Conditions. PG - 5973484 LID - 10.1155/2018/5973484 [doi] LID - 5973484 AB - Nowadays, bacteriocin industry has substantially grown replacing the role of chemical preservatives in enhancing shelf-life and safety of food. The progress in bacteriocin study has been supported by the emerging of consumer demand on the applications of natural food preservatives. Since food is a complex ecosystem, the characteristics of bacteriocin determine the effectiveness of their incorporation into the food products. Among four commercial media (M17 broth, MRS broth, tryptic soy broth, and nutrient broth) tested, the highest growth of Pediococcus acidilactici kp10 and bacteriocin-like-inhibitory substance (BLIS) production were obtained in the cultivation with M17. BLIS production was found to be a growth associated process where the production was increased concomitantly with the growth of producing strain, P. acidilactici kp10. The antimicrobial property of BLIS against three indicator microorganisms (Listeria monocytogenes, Escherichia coli, and Staphylococcus aureus) remained stable upon heating at 100°C but not detectable at 121°C. The BLIS activity was also observed to be stable and active at a wide pH range (pH 2 to pH 7). The BLIS activity remained constant at -20°C and -80°C for 1 month of storage. However, the activity dropped after 3 and 6 months of storage at 4°C, -20°C, and -80°C with more than 80% reduction. The ability of bacteriocin from P. acidilactici kp10 to inhibit food-borne pathogens while remaining stable and active at extreme pH and temperature is of potential interest for future applications in food preservatives. FAU - Md Sidek, Nurul Lyana AU - Md Sidek NL AD - Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. FAU - Halim, Murni AU - Halim M AUID- ORCID: 0000-0002-5744-2147 AD - Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. AD - Bioprocessing and Biomanufacturing Research Centre, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. FAU - Tan, Joo Shun AU - Tan JS AD - Bioprocess Technology, School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia. FAU - Abbasiliasi, Sahar AU - Abbasiliasi S AD - Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. AD - Halal Products Research Institute, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. FAU - Mustafa, Shuhaimi AU - Mustafa S AD - Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. AD - Halal Products Research Institute, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. FAU - Ariff, Arbakariya B AU - Ariff AB AUID- ORCID: 0000-0001-9521-9379 AD - Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. AD - Bioprocessing and Biomanufacturing Research Centre, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. LA - eng PT - Journal Article DEP - 20180927 PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 RN - 0 (Anti-Bacterial Agents) RN - 0 (Bacteriocins) RN - 0 (Food Preservatives) SB - IM MH - Anti-Bacterial Agents/*pharmacology MH - Bacteria/drug effects MH - Bacteriocins/*metabolism/*pharmacology MH - Food Preservatives/*pharmacology MH - Hydrogen-Ion Concentration MH - Pediococcus acidilactici/*metabolism MH - Temperature PMC - PMC6180926 EDAT- 2018/10/27 06:00 MHDA- 2019/02/05 06:00 PMCR- 2018/09/27 CRDT- 2018/10/27 06:00 PHST- 2018/07/20 00:00 [received] PHST- 2018/09/12 00:00 [accepted] PHST- 2018/10/27 06:00 [entrez] PHST- 2018/10/27 06:00 [pubmed] PHST- 2019/02/05 06:00 [medline] PHST- 2018/09/27 00:00 [pmc-release] AID - 10.1155/2018/5973484 [doi] PST - epublish SO - Biomed Res Int. 2018 Sep 27;2018:5973484. doi: 10.1155/2018/5973484. eCollection 2018. PMID- 26615171 OWN - NLM STAT- MEDLINE DCOM- 20160930 LR - 20240724 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 33 Suppl 4 DP - 2015 Nov 27 TI - Vaccine hesitancy: Causes, consequences, and a call to action. PG - D66-71 LID - S0264-410X(15)01311-0 [pii] LID - 10.1016/j.vaccine.2015.09.035 [doi] AB - Vaccine hesitancy reflects concerns about the decision to vaccinate oneself or one's children. There is a broad range of factors contributing to vaccine hesitancy, including the compulsory nature of vaccines, their coincidental temporal relationships to adverse health outcomes, unfamiliarity with vaccine-preventable diseases, and lack of trust in corporations and public health agencies. Although vaccination is a norm in the U.S. and the majority of parents vaccinate their children, many do so amid concerns. The proportion of parents claiming non-medical exemptions to school immunization requirements has been increasing over the past decade. Vaccine refusal has been associated with outbreaks of invasive Haemophilus influenzae type b disease, varicella, pneumococcal disease, measles, and pertussis, resulting in the unnecessary suffering of young children and waste of limited public health resources. Vaccine hesitancy is an extremely important issue that needs to be addressed because effective control of vaccine-preventable diseases generally requires indefinite maintenance of extremely high rates of timely vaccination. The multifactorial and complex causes of vaccine hesitancy require a broad range of approaches on the individual, provider, health system, and national levels. These include standardized measurement tools to quantify and locate clustering of vaccine hesitancy and better understand issues of trust; rapid, independent, and transparent review of an enhanced and appropriately funded vaccine safety system; adequate reimbursement for vaccine risk communication in doctors' offices; and individually tailored messages for parents who have vaccine concerns, especially first-time pregnant women. The potential of vaccines to prevent illness and save lives has never been greater. Yet, that potential is directly dependent on parental acceptance of vaccines, which requires confidence in vaccines, healthcare providers who recommend and administer vaccines, and the systems to make sure vaccines are safe. CI - Copyright © 2015 American Journal of Preventive Medicine and Elsevier Ltd. Published by Elsevier Ltd.. All rights reserved. FAU - Salmon, Daniel A AU - Salmon DA AD - Departments of International Health and Health, Behavior, and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: dsalmon1@jhu.edu. FAU - Dudley, Matthew Z AU - Dudley MZ AD - Institute for Vaccine Safety, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Glanz, Jason M AU - Glanz JM AD - Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, United States; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States. FAU - Omer, Saad B AU - Omer SB AD - Rollins School of Public Health, Emory University, Atlanta, GA, United States. LA - eng PT - Journal Article PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Vaccines) SB - IM MH - Child MH - Disease Outbreaks/*prevention & control MH - Female MH - Health Knowledge, Attitudes, Practice MH - Health Personnel MH - Humans MH - *Immunization Programs MH - *Parents/psychology MH - Patient Compliance/psychology MH - Pregnancy MH - *Treatment Refusal/psychology MH - United States MH - Vaccination/psychology MH - Vaccines/*adverse effects EDAT- 2015/11/29 06:00 MHDA- 2016/10/01 06:00 CRDT- 2015/11/29 06:00 PHST- 2015/11/29 06:00 [entrez] PHST- 2015/11/29 06:00 [pubmed] PHST- 2016/10/01 06:00 [medline] AID - S0264-410X(15)01311-0 [pii] AID - 10.1016/j.vaccine.2015.09.035 [doi] PST - ppublish SO - Vaccine. 2015 Nov 27;33 Suppl 4:D66-71. doi: 10.1016/j.vaccine.2015.09.035. PMID- 20625296 OWN - NLM STAT- MEDLINE DCOM- 20110201 LR - 20101013 IS - 1473-6586 (Electronic) IS - 0963-0643 (Linking) VI - 20 IP - 6 DP - 2010 Nov TI - Inflatable penile prostheses: an update. PG - 459-64 LID - 10.1097/MOU.0b013e32833d14df [doi] AB - PURPOSE OF REVIEW: Since the advent of oral medication for the treatment of erectile dysfunction the disease has garnered increasing attention by both scientists and the general public alike. Coinciding with this, more patients are seeking treatment of their disease. When medical management is not successful, surgical implantation of a penile prosthesis may be considered. RECENT FINDINGS: Because inflatable penile prostheses are vastly preferred by patients over noninflatable prostheses, this review will focus on their current use, reported durability and safety, and patient satisfaction. SUMMARY: Inflatable penile prostheses are associated with decreasing risks of infection and device malfunction and extremely high patient and partner satisfaction rates. Because of this, inflatable penile prostheses remain a viable tertiary treatment option for erectile dysfunction. FAU - Lightfoot, Andrew J AU - Lightfoot AJ AD - Department of Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA. FAU - Rosevear, Henry M AU - Rosevear HM FAU - Kreder, Karl J AU - Kreder KJ LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Urol JT - Current opinion in urology JID - 9200621 SB - IM MH - Erectile Dysfunction/*surgery MH - Humans MH - Male MH - Patient Satisfaction MH - *Penile Prosthesis MH - Prosthesis Design MH - Treatment Outcome EDAT- 2010/07/14 06:00 MHDA- 2011/02/02 06:00 CRDT- 2010/07/14 06:00 PHST- 2010/07/14 06:00 [entrez] PHST- 2010/07/14 06:00 [pubmed] PHST- 2011/02/02 06:00 [medline] AID - 10.1097/MOU.0b013e32833d14df [doi] PST - ppublish SO - Curr Opin Urol. 2010 Nov;20(6):459-64. doi: 10.1097/MOU.0b013e32833d14df. PMID- 34758837 OWN - NLM STAT- MEDLINE DCOM- 20211112 LR - 20211117 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 21 IP - 1 DP - 2021 Nov 10 TI - From chaos to control - experiences of healthcare workers during the early phase of the COVID-19 pandemic: a focus group study. PG - 1219 LID - 10.1186/s12913-021-07248-9 [doi] LID - 1219 AB - BACKGROUND: The Coronavirus disease 2019 (COVID-19) pandemic has caused overwhelming challenges to healthcare systems worldwide. Healthcare workers (HCWs) have faced particular challenges: being exposed to the coronavirus SARS-CoV-2 and caring for patients having a new and potentially life-threatening disease. The aim of this study was to explore how HCWs in the Swedish healthcare system perceived their work situation during the first phase of the COVID-19 pandemic in 2020. METHODS: Focus group discussions and interviews with HCWs were performed from June to October 2020 in one Swedish healthcare region. A purposeful sampling approach was used to select a variety of professions (physicians, nurses, nurse aides and cleaners) and workplaces (hospital inpatient wards, emergency department, nursing home and home care service). Qualitative content analysis was used for data analysis. RESULTS: In total, 51 HCWs participated in eight focus group discussions and one HCW participated in an individual interview. The content analysis identified two main categories: 'Concerns about the risk of infection and transmission of infection to others', and 'Transition from chaos to managing in a new and challenging work situation'. The findings revealed how HCWs perceived working conditions, including experiences of fear for personal health, confusion and uncertainty regarding personal protective equipment and infection prevention and control (PPE/IPC), and fear of infecting others. Both fearful and appreciating attitudes were achieved from the surrounding community. Helpful strategies for transition from chaos to control were lifted i.e. present and supportive leadership, and finding comfort and strength in the working team. Both helplessness and meaningfulness were described when caring for COVID-19 patients. CONCLUSIONS: This study provides unique insights into HCWs experiences of an extremely challenging work situation during the first phase of the COVID-19 pandemic, including feelings of stress and insecurity in a chaotic and hazardous working environment. But there is also mitigation of these challenges and even positive experiences including feelings of safety and meaningfulness. To enhance safety among HCWs in healthcare crises such as the COVID-19 pandemic, the findings highlight the importance of avoiding confusion about PPE/IPC, having a supportive healthcare leadership and ensuring accurate information provision about virus transmission to the public. CI - © 2021. The Author(s). FAU - Rücker, Fredrik AU - Rücker F AD - Department of Infectious Diseases, Falun hospital, Infektionskliniken, Falu lasarett, SE-79182, Falun, Sweden. AD - Center for Clinical Research Dalarna - Uppsala University, Nissers väg 3, SE-79182, Falun, Sweden. FAU - Hårdstedt, Maria AU - Hårdstedt M AD - Center for Clinical Research Dalarna - Uppsala University, Nissers väg 3, SE-79182, Falun, Sweden. AD - School of Medical Sciences, Faculty of Medicine and Health, Örebro University, SE-70182, Örebro, Sweden. AD - Vansbro Primary Health Care Center, Moravägen 27, SE-78633, Vansbro, Sweden. FAU - Rücker, Sekai Chenai Mathabire AU - Rücker SCM AD - Department of Infectious Diseases, Falun hospital, Infektionskliniken, Falu lasarett, SE-79182, Falun, Sweden. AD - Center for Clinical Research Dalarna - Uppsala University, Nissers väg 3, SE-79182, Falun, Sweden. FAU - Aspelin, Emma AU - Aspelin E AD - Department of Infectious Diseases, Falun hospital, Infektionskliniken, Falu lasarett, SE-79182, Falun, Sweden. FAU - Smirnoff, Alexander AU - Smirnoff A AD - Department of Infectious Diseases, Falun hospital, Infektionskliniken, Falu lasarett, SE-79182, Falun, Sweden. FAU - Lindblom, Anders AU - Lindblom A AD - Department of Infectious Diseases, Falun hospital, Infektionskliniken, Falu lasarett, SE-79182, Falun, Sweden. AD - Center for Clinical Research Dalarna - Uppsala University, Nissers väg 3, SE-79182, Falun, Sweden. AD - Department of Infectious Control, Falu Hospital, Region Dalarna, Smittskyddsenheten, Falu lasarett, SE-79182, Falun, Sweden. AD - Unit of Infectious Diseases, Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Infektion, SE-75185, Uppsala, Sweden. FAU - Gustavsson, Catharina AU - Gustavsson C AUID- ORCID: 0000-0002-8709-4446 AD - Center for Clinical Research Dalarna - Uppsala University, Nissers väg 3, SE-79182, Falun, Sweden. catharina.gustavsson@regiondalarna.se. AD - Department of Public Health and Caring Sciences, Uppsala university, BMC Box 564, SE-751 22, Uppsala, Sweden. catharina.gustavsson@regiondalarna.se. AD - School of Health and Welfare, Dalarna university, SE-79188, Falun, Sweden. catharina.gustavsson@regiondalarna.se. LA - eng PT - Journal Article DEP - 20211110 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - *COVID-19 MH - Focus Groups MH - Health Personnel MH - Humans MH - *Pandemics/prevention & control MH - SARS-CoV-2 PMC - PMC8579171 OTO - NOTNLM OT - Coronavirus disease 2019 OT - Health personnel OT - Infection control OT - Mental health OT - Occupational health OT - Patient care OT - Qualitative research COIS- The authors declare that they have no competing interests. EDAT- 2021/11/12 06:00 MHDA- 2021/11/16 06:00 PMCR- 2021/11/10 CRDT- 2021/11/11 05:43 PHST- 2021/08/09 00:00 [received] PHST- 2021/11/01 00:00 [accepted] PHST- 2021/11/11 05:43 [entrez] PHST- 2021/11/12 06:00 [pubmed] PHST- 2021/11/16 06:00 [medline] PHST- 2021/11/10 00:00 [pmc-release] AID - 10.1186/s12913-021-07248-9 [pii] AID - 7248 [pii] AID - 10.1186/s12913-021-07248-9 [doi] PST - epublish SO - BMC Health Serv Res. 2021 Nov 10;21(1):1219. doi: 10.1186/s12913-021-07248-9. PMID- 25198607 OWN - NLM STAT- MEDLINE DCOM- 20141208 LR - 20230307 IS - 1944-9097 (Electronic) IS - 0362-028X (Linking) VI - 77 IP - 8 DP - 2014 Aug TI - External pH is a cue for the behavioral switch that determines surface motility and biofilm formation of Alicyclobacillus acidoterrestris. PG - 1418-23 LID - 10.4315/0362-028X.JFP-13-425 [doi] AB - Bacteria use different strategies to survive unfavorable environmental conditions. Alicyclobacillus acidoterrestris is a bacterium capable of surviving extremely harsh conditions, for instance, during industrial food processing. A. acidoterrestris is a spore-forming, thermoacidophilic, nonpathogenic bacterium that commonly contaminates commercial pasteurized fruit juices and is, therefore, considered a major microbiological contaminant in the juice industry. The purpose of this study was to elucidate whether A. acidoterrestris is capable of multicellular behavior by testing its ability of biofilm formation and surface motility. A. acidoterrestris was found to be proficient in migration over a surface that is apparently powered by flagella. It was further shown that lowering the external pH leads to inhibition in surface motility of these bacteria. Concomitantly, the reduction in the external pH triggered biofilm formation of A. acidoterrestris cells. Thus, although no significant biofilm was formed at pH 4.5, robust cell adhesion and confluent biofilm formation was seen below the pH 3.6. These findings indicate that the reduction of external pH is an environmental cue for the behavioral switch that inhibits surface motility and triggers biofilm formation of A. acidoterrestris. Gaining insight into the multicellular behavior that facilitates A. acidoterrestris survival in food contact surfaces may contribute to the development of novel antimicrobial means to prevent cross-contamination caused by this bacterium. FAU - Shemesh, Moshe AU - Shemesh M AD - Department of Food Quality and Safety, Institute for Postharvest Technology and Food Sciences, Agricultural Research Organization (ARO), The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel. moshesh@agri.gov.il. FAU - Pasvolsky, Ronit AU - Pasvolsky R AD - Department of Food Quality and Safety, Institute for Postharvest Technology and Food Sciences, Agricultural Research Organization (ARO), The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. FAU - Zakin, Varda AU - Zakin V AD - Department of Food Quality and Safety, Institute for Postharvest Technology and Food Sciences, Agricultural Research Organization (ARO), The Volcani Center, P.O. Box 6, Bet-Dagan 50250, Israel. LA - eng PT - Journal Article PL - United States TA - J Food Prot JT - Journal of food protection JID - 7703944 SB - IM MH - Alicyclobacillus/*cytology/*physiology MH - *Biofilms MH - Food Handling/instrumentation MH - Hydrogen-Ion Concentration MH - Spores, Bacterial/growth & development EDAT- 2014/09/10 06:00 MHDA- 2014/12/15 06:00 CRDT- 2014/09/09 06:00 PHST- 2014/09/09 06:00 [entrez] PHST- 2014/09/10 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - S0362-028X(23)06175-6 [pii] AID - 10.4315/0362-028X.JFP-13-425 [doi] PST - ppublish SO - J Food Prot. 2014 Aug;77(8):1418-23. doi: 10.4315/0362-028X.JFP-13-425. PMID- 39247720 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240910 IS - 1178-6302 (Print) IS - 1178-6302 (Electronic) IS - 1178-6302 (Linking) VI - 18 DP - 2024 TI - Media-Based Post-Event Impact Analysis of the 2021 Heat Dome in Canada. PG - 11786302241276669 LID - 10.1177/11786302241276669 [doi] LID - 11786302241276669 AB - The unprecedented 2021 Heat Dome caused wide-ranging and long-lasting impacts in western Canada, including 619 confirmed heat-related deaths in British Columbia, a doubling of emergency medical calls, increased hospitalisations, infrastructure failures and stress on plants and animals. However, such varied socio-economic consequences of extreme heat can be challenging to capture using a single post-event analysis method. Therefore, there is a need to explore alternative approaches and data sources. Using the 2021 Heat Dome as a case study, a post-event analysis using online news media articles (n = 2909) from 5 subscription news databases and a grey literature search was conducted to identify the socio-economic impacts of the extreme heat event in Canada. The articles reported a wide range of effects to the natural environment (n = 1366), social infrastructure and services (n = 1121), human health (n = 1074), critical infrastructure (n = 988) and the private sector (n = 165). The media-based post-event analysis captured various impacts, some of which have not been identified through other data sources and approaches. Overall, we show that media analysis can complement traditional post-event analysis methods and provide additional perspectives to governments and public health and safety officials. CI - © The Author(s) 2024. FAU - Tetzlaff, Emily J AU - Tetzlaff EJ AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. AD - Heat Division, Climate Change and Health Office, Health Canada, Ottawa, ON, Canada. FAU - Goulet, Nicholas AU - Goulet N AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. AD - Heat Division, Climate Change and Health Office, Health Canada, Ottawa, ON, Canada. AD - Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. FAU - Gorman, Melissa AU - Gorman M AD - Heat Division, Climate Change and Health Office, Health Canada, Ottawa, ON, Canada. FAU - Richardson, Gregory Ra AU - Richardson GR AD - Heat Division, Climate Change and Health Office, Health Canada, Ottawa, ON, Canada. FAU - Enright, Paddy M AU - Enright PM AD - Heat Division, Climate Change and Health Office, Health Canada, Ottawa, ON, Canada. FAU - Henderson, Sarah B AU - Henderson SB AD - Environmental Health Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada. FAU - Kenny, Glen P AU - Kenny GP AD - Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. AD - Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20240905 PL - United States TA - Environ Health Insights JT - Environmental health insights JID - 101488505 PMC - PMC11378224 OTO - NOTNLM OT - Extreme heat event OT - climate change OT - heat wave OT - impact analysis OT - risk communication COIS- The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2024/09/09 06:42 MHDA- 2024/09/09 06:43 PMCR- 2024/09/05 CRDT- 2024/09/09 05:14 PHST- 2024/05/27 00:00 [received] PHST- 2024/07/25 00:00 [accepted] PHST- 2024/09/09 06:43 [medline] PHST- 2024/09/09 06:42 [pubmed] PHST- 2024/09/09 05:14 [entrez] PHST- 2024/09/05 00:00 [pmc-release] AID - 10.1177_11786302241276669 [pii] AID - 10.1177/11786302241276669 [doi] PST - epublish SO - Environ Health Insights. 2024 Sep 5;18:11786302241276669. doi: 10.1177/11786302241276669. eCollection 2024. PMID- 37078758 OWN - NLM STAT- MEDLINE DCOM- 20230502 LR - 20230503 IS - 1744-8417 (Electronic) IS - 1744-6651 (Linking) VI - 18 IP - 3 DP - 2023 May TI - Treatment of type 2 diabetes patients with heart conditions. PG - 255-265 LID - 10.1080/17446651.2023.2204941 [doi] AB - INTRODUCTION: While type 2 diabetes mellitus (T2DM) increases the risk of cardiac complications, diabetes treatment choices may increase or decrease the rates of cardiac events. In the present review, we comprehensively discussed the treatment options of diabetic subjects with cardiac conditions. AREAS COVERED: Current evidence related to diabetes treatment in cardiac situations has been reviewed. Clinical trials and meta-analyses on cardiac safety of anti-diabetic medicines are discussed. Treatment choices with proven benefits and those at least without associated increased cardiac risk were drawn from clinical trials; meta-analyses and cardiac safety studies in the recent medical literature were the basis of the suggestions in the present review. EXPERT OPINION: We can suggest that hypoglycemia and extreme hyperglycemia should be avoided in acute ischemic heart conditions. Certain diabetic treatment options, especially sodium-glucose cotransporter-2 (SGLT2) inhibitors, can reduce overall cardiovascular mortality and hospitalization due to heart failure. Therefore, we suggest that physicians should choose SGLT2 inhibitors as the first-line treatment option in diabetic patients with heart failure or those who have a high risk of heart failure development. T2DM increases the risk of atrial fibrillation (AF), and metformin and pioglitazone seem to reduce the risk of AF in diabetic population. FAU - Aktas, Gulali AU - Aktas G AUID- ORCID: 0000-0001-7306-5233 AD - Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey. FAU - Atak Tel, Burcin Meryem AU - Atak Tel BM AUID- ORCID: 0000-0003-4201-9757 AD - Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey. FAU - Tel, Ramiz AU - Tel R AUID- ORCID: 0000-0001-7521-4060 AD - Izzet Baysal State Hospital, Department of Emergency, Bolu, Turkey. FAU - Balci, Buse AU - Balci B AUID- ORCID: 0000-0003-3651-4858 AD - Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey. LA - eng PT - Journal Article PT - Review DEP - 20230420 PL - England TA - Expert Rev Endocrinol Metab JT - Expert review of endocrinology & metabolism JID - 101278293 RN - 0 (Sodium-Glucose Transporter 2 Inhibitors) RN - 9100L32L2N (Metformin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/complications/drug therapy MH - *Cardiovascular Diseases/prevention & control/complications MH - *Sodium-Glucose Transporter 2 Inhibitors/therapeutic use/pharmacology MH - *Metformin/therapeutic use MH - *Heart Failure/drug therapy OTO - NOTNLM OT - Type 2 diabetes mellitus OT - atrial fibrillation OT - cardiac conditions OT - diabetes treatment OT - heart failure EDAT- 2023/04/20 13:41 MHDA- 2023/05/02 06:42 CRDT- 2023/04/20 09:22 PHST- 2023/05/02 06:42 [medline] PHST- 2023/04/20 13:41 [pubmed] PHST- 2023/04/20 09:22 [entrez] AID - 10.1080/17446651.2023.2204941 [doi] PST - ppublish SO - Expert Rev Endocrinol Metab. 2023 May;18(3):255-265. doi: 10.1080/17446651.2023.2204941. Epub 2023 Apr 20. PMID- 22357403 OWN - NLM STAT- MEDLINE DCOM- 20120402 LR - 20131121 IS - 1545-861X (Electronic) IS - 0149-2195 (Linking) VI - 61 IP - 7 DP - 2012 Feb 24 TI - Fatal exposure to methylene chloride among bathtub refinishers - United States, 2000-2011. PG - 119-22 AB - In 2010, the Michigan Fatality Assessment and Control Evaluation program conducted an investigation into the death of a bathtub refinisher who used a methylene chloride-based paint stripping product marketed for use in aircraft maintenance. The program identified two earlier, similar deaths in Michigan. Program staff members notified CDC's National Institute for Occupational Safety and Health (NIOSH), which in turn notified the Occupational Safety and Health Administration (OSHA). In addition to the three deaths, OSHA identified 10 other bathtub refinisher fatalities associated with methylene chloride stripping agents that had been investigated in nine states during 2000-2011. Each death occurred in a residential bathroom with inadequate ventilation. Protective equipment, including a respirator, either was not used or was inadequate to protect against methylene chloride vapor, which has been recognized as potentially fatal to furniture strippers and factory workers but has not been reported previously as a cause of death among bathtub refinishers. Worker safety agencies, public health agencies, methylene chloride-based stripper manufacturers, and trade organizations should communicate the extreme hazards of using methylene chloride-based stripping products in bathtub refinishing to employers, workers, and consumers. Employers should strongly consider alternative methods of bathtub stripping and always ensure worker safety protections that reduce the risk for health hazards to acceptable levels. Employers choosing to use methylene chloride-based stripping products must comply with OSHA's standard to limit methylene chloride exposures to safe levels. CN - Centers for Disease Control and Prevention (CDC) LA - eng PT - Case Reports PT - Journal Article PL - United States TA - MMWR Morb Mortal Wkly Rep JT - MMWR. Morbidity and mortality weekly report JID - 7802429 RN - 0 (Solvents) RN - 588X2YUY0A (Methylene Chloride) SB - IM MH - Adult MH - Baths MH - Fatal Outcome MH - Female MH - Heart Arrest/chemically induced MH - Humans MH - Inhalation Exposure MH - Male MH - Methylene Chloride/*poisoning MH - Middle Aged MH - Occupational Exposure/*adverse effects MH - Paint MH - Respiratory Protective Devices MH - Solvents/*poisoning MH - United States MH - United States Occupational Safety and Health Administration MH - Ventilation MH - Young Adult EDAT- 2012/02/24 06:00 MHDA- 2012/04/03 06:00 CRDT- 2012/02/24 06:00 PHST- 2012/02/24 06:00 [entrez] PHST- 2012/02/24 06:00 [pubmed] PHST- 2012/04/03 06:00 [medline] AID - mm6107a2 [pii] PST - ppublish SO - MMWR Morb Mortal Wkly Rep. 2012 Feb 24;61(7):119-22. PMID- 30672901 OWN - NLM STAT- MEDLINE DCOM- 20200529 LR - 20200529 IS - 1535-1815 (Electronic) IS - 0749-5161 (Linking) VI - 36 IP - 1 DP - 2020 Jan TI - Surgical Emphysema in a Pediatric Tertiary Referral Center. PG - e21-e24 LID - 10.1097/PEC.0000000000001725 [doi] AB - BACKGROUND: Laryngeal trauma in pediatrics is extremely rare; however, because of the smaller pediatric larynx, it can have catastrophic consequences. Following laryngeal trauma, surgical emphysema is a relatively common presentation. In pediatrics, it can be a life-threatening condition. Here we describe 2 cases of laryngeal trauma resulting in extensive surgical emphysema. CASES: The first case described involves bilateral pneumothoraces, airway compromise, and respiratory arrest and was managed with bilateral chest drains, intubation, and tracheostomy. The second case resulted in widespread surgical emphysema in a stable patient and was managed conservatively. Both cases were monitored closely for a period of time to ensure there were no further sequelae. DISCUSSION: Patients with laryngeal trauma resulting in surgical emphysema have the potential to deteriorate rapidly. Furthermore, surgical emphysema degrades the quality of ultrasound images, which may delay the diagnosis. If there are any concerns about the safety of the airway, then it should be secured definitively with either endotracheal intubation or emergency tracheostomy depending on clinical judgment. It is acceptable to monitor patients closely in a high-dependency unit setting if they are stable and do not show any evidence of laryngeal edema. CONCLUSIONS: We present 2 cases of laryngeal trauma that were dealt with effectively so that both patients made a full recovery. It is important to act quickly to secure the airway if there are any concerns about its patency. Stable patients with no evidence of laryngeal edema can be managed conservatively. Close monitoring is essential to prevent any potential airway compromise. FAU - Harrison, Rebecca AU - Harrison R AD - From the Royal Manchester Children's Hospital, Manchester, England. FAU - Knowles, Stuart AU - Knowles S FAU - Doherty, Catherine AU - Doherty C LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Pediatr Emerg Care JT - Pediatric emergency care JID - 8507560 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Larynx/*injuries MH - Male MH - Neck Injuries/complications MH - Pneumothorax/diagnostic imaging/*etiology/therapy MH - Radiography, Thoracic MH - Resuscitation/methods MH - Subcutaneous Emphysema/diagnostic imaging/*etiology/therapy MH - Tertiary Care Centers MH - Tomography, X-Ray Computed MH - Trachea/*injuries EDAT- 2019/01/24 06:00 MHDA- 2020/05/30 06:00 CRDT- 2019/01/24 06:00 PHST- 2019/01/24 06:00 [pubmed] PHST- 2020/05/30 06:00 [medline] PHST- 2019/01/24 06:00 [entrez] AID - 10.1097/PEC.0000000000001725 [doi] PST - ppublish SO - Pediatr Emerg Care. 2020 Jan;36(1):e21-e24. doi: 10.1097/PEC.0000000000001725. PMID- 8486828 OWN - NLM STAT- MEDLINE DCOM- 19930604 LR - 20190814 IS - 0363-8715 (Print) IS - 0363-8715 (Linking) VI - 17 Suppl 1 DP - 1993 TI - MR imaging advances in practice. PG - S30-5 AB - Efficacy and safety of gadolinium contrast agents in MR imaging of the brain and spine are examined first in the context of clinical experience at the Barrow Neurological Institute. The role played by the absence and the presence of contrast enhancement in confirming or ruling out diagnostic suspicions is emphasized. Findings from multicenter phase I-III efficacy and safety studies of gadopentetate dimeglumine, gadodiamide, and gadoteridol in head and back imaging are reviewed. All three agents add diagnostic information, increase diagnostic confidence, and are extremely safe, readily tolerated compounds exhibiting generally mild side-effect profiles. Gadolinium-enhanced MR scanning is placed in the longer perspective of diagnostic imaging strategies, to consider the assignment of priorities to various modalities according to the suspected disease at hand. FAU - Drayer, B P AU - Drayer BP AD - Barrow Neurological Institute, Phoenix, AZ 85013. LA - eng PT - Journal Article PT - Review PL - United States TA - J Comput Assist Tomogr JT - Journal of computer assisted tomography JID - 7703942 RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Brain Diseases/*diagnosis MH - *Gadolinium/adverse effects MH - Humans MH - Image Enhancement/*methods MH - Magnetic Resonance Imaging/*trends MH - Spinal Cord Diseases/*diagnosis RF - 9 EDAT- 1993/01/01 00:00 MHDA- 1993/01/01 00:01 CRDT- 1993/01/01 00:00 PHST- 1993/01/01 00:00 [pubmed] PHST- 1993/01/01 00:01 [medline] PHST- 1993/01/01 00:00 [entrez] AID - 10.1097/00004728-199301001-00006 [doi] PST - ppublish SO - J Comput Assist Tomogr. 1993;17 Suppl 1:S30-5. doi: 10.1097/00004728-199301001-00006. PMID- 31410362 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2321-3868 (Print) IS - 2321-3876 (Electronic) IS - 2321-3868 (Linking) VI - 7 DP - 2019 TI - Optimized clinical practice for superaged patients with hip fracture: significance of damage control and enhanced recovery program. PG - 21 LID - 10.1186/s41038-019-0159-y [doi] LID - 21 AB - With the advent of global aging, the incidence, mortality, and medical costs of hip fracture among aged patients are increasing annually. The number of controlled clinical studies and health economics analyses that conform to evidence-based medicine principles is growing day by day. However, unfortunately, no specific recommendations regarding the procedures for the treatment of hip fracture are available. Meanwhile, the existence of both traditional treatment systems and new treatment theories means that most doctors confront difficult choices in their daily practice. These factors make the therapeutic approach for aged patients, especially among superaged patients with hip fracture, extremely challenging. This study focuses on superaged patients (> 80 years as defined by the World Health Organization) with hip fracture and includes their preoperative pathological condition; therapeutic decision-making in terms of the benefit and risk ratio, damage control theory, and enhanced recovery after surgery were also investigated. These patients were discussed specifically by combining the current treatment strategies from several experts and the results of a meta-analysis published recently. The study presents some new ideas and approaches currently recognized in the field, such as preoperative assessment, surgical planning, safety consideration, complication intervention, and enhanced recovery implementation, and further presents some clear interpretations regarding misunderstandings in clinical practice. Finally, optimized treatment according to damage control principles and enhanced recovery after surgery during the perioperative period among superaged hip fracture patients is defined. FAU - Liu, Zaiyang AU - Liu Z AD - Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 China. FAU - Zhang, Jun AU - Zhang J AD - Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 China. FAU - He, Kaiqi AU - He K AD - Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 China. FAU - Zhang, Yumei AU - Zhang Y AD - Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 China. FAU - Zhang, Yuan AU - Zhang Y AUID- ORCID: 0000-0002-3122-1143 AD - Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, 400037 China. LA - eng PT - Journal Article PT - Review DEP - 20190808 PL - England TA - Burns Trauma JT - Burns & trauma JID - 101651457 PMC - PMC6686476 OTO - NOTNLM OT - Damage control OT - Elderly orthopedic care OT - Femoral intertrochanteric fracture OT - Femoral neck fracture OT - Hip fracture OT - Superaged patient COIS- Competing interestsThe authors declare that they have no competing interests. EDAT- 2019/08/15 06:00 MHDA- 2019/08/15 06:01 PMCR- 2019/08/08 CRDT- 2019/08/15 06:00 PHST- 2018/12/13 00:00 [received] PHST- 2019/05/06 00:00 [accepted] PHST- 2019/08/15 06:00 [entrez] PHST- 2019/08/15 06:00 [pubmed] PHST- 2019/08/15 06:01 [medline] PHST- 2019/08/08 00:00 [pmc-release] AID - 159 [pii] AID - 10.1186/s41038-019-0159-y [doi] PST - epublish SO - Burns Trauma. 2019 Aug 8;7:21. doi: 10.1186/s41038-019-0159-y. eCollection 2019. PMID- 26182766 OWN - NLM STAT- MEDLINE DCOM- 20150827 LR - 20181202 IS - 1025-9589 (Print) IS - 1025-9589 (Linking) VI - 27 IP - 1 DP - 2015 Jan-Mar TI - THE QUANTITATIVE EVIDENCE OF MALARIAL TRANSMISSION AND ITS ASSOCIATES IN BAHAWALPUR, PAKISTAN. PG - 164-7 AB - BACKGROUND: Malaria transmission is an extremely complex condition that is manifested differently in different parts of the world. In Pakistan, malaria is still endemic in many areas. Plasmodium vivax and Plasmodium falciparum are identified to be the most prevalent species of malaria in-Pakistan. A great deal of work regarding malarial transmission is available at regional level in Pakistan but the evidence of malaria with its associates in Bahawalpur is scarce. The present study was planned to see the pattern of malarial transmission in the city of Bahawalpur, Pakistan. METHODS: In this cross-sectional study data on 1623 subjects was collected. Giemsa stain thick and thin blood films were used as diagnostic tools for malarial transmission. Bivariate statistical analysis in addition was employed to identify the associates of malarial prevalence. RESULTS: Out of 1623 subjects screened, 70 (4.3%) were found infected. Plasmodium vivax was seen in the majority 61 (77.2%). Plasmodium falciparum was the second common-species identified in 16 (22.8%) cases. As expected place of residence, window screening, malarial knowledge and behaviours of sleeping were seen to be significant associates of malarial transmission in Bahawalpur. CONCLUSION: The findings revealed that Bahawalpur falls in the category of low to moderate level malarial transmission as compared to other regions of Pakistan. Plasmodium vivax was the commonest type of malaria diagnosed in Bahawalpur. Geographic location, house safety, malarial knowledge, and behaviour of sleeping are the highly significant associates of malarial transmission in Bahawalpur. FAU - Zaidi, Syed Arif Ahmed AU - Zaidi SA FAU - Kokab, Farkhanda AU - Kokab F FAU - Bukhari, Ijaz Ahmad AU - Bukhari IA FAU - Nasir, Jamal Abdul AU - Nasir JA LA - eng PT - Journal Article PL - Pakistan TA - J Ayub Med Coll Abbottabad JT - Journal of Ayub Medical College, Abbottabad : JAMC JID - 8910750 SB - IM MH - Cross-Sectional Studies MH - Female MH - Humans MH - Malaria/epidemiology/*transmission MH - Male MH - Pakistan/epidemiology MH - Plasmodium falciparum/*isolation & purification MH - Plasmodium vivax/*isolation & purification MH - Prevalence MH - Retrospective Studies EDAT- 2015/07/18 06:00 MHDA- 2015/08/28 06:00 CRDT- 2015/07/18 06:00 PHST- 2015/07/18 06:00 [entrez] PHST- 2015/07/18 06:00 [pubmed] PHST- 2015/08/28 06:00 [medline] PST - ppublish SO - J Ayub Med Coll Abbottabad. 2015 Jan-Mar;27(1):164-7. PMID- 12371268 OWN - NLM STAT- MEDLINE DCOM- 20021106 LR - 20071115 IS - 0377-8231 (Print) IS - 0377-8231 (Linking) VI - 156 IP - 10-12 DP - 2001 TI - [Obesity: therapeutic aspects]. PG - 471-9; discussion 480-2 AB - Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality. FAU - Scheen, A AU - Scheen A AD - Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine, C.H.U. Sart Tilman-Liège. LA - fre PT - English Abstract PT - Journal Article TT - Obésité: aspects thérapeutiques. PL - Belgium TA - Bull Mem Acad R Med Belg JT - Bulletin et memoires de l'Academie royale de medecine de Belgique JID - 7608462 SB - IM MH - Humans MH - Life Style MH - Obesity/*rehabilitation/*therapy MH - Patient Education as Topic EDAT- 2002/10/10 04:00 MHDA- 2002/11/26 04:00 CRDT- 2002/10/10 04:00 PHST- 2002/10/10 04:00 [pubmed] PHST- 2002/11/26 04:00 [medline] PHST- 2002/10/10 04:00 [entrez] PST - ppublish SO - Bull Mem Acad R Med Belg. 2001;156(10-12):471-9; discussion 480-2. PMID- 34433171 OWN - NLM STAT- MEDLINE DCOM- 20220401 LR - 20220401 IS - 1662-2782 (Electronic) IS - 0302-5144 (Linking) VI - 199 DP - 2021 TI - Motor Vehicle Injury and Kidney Damage: Trauma, Rhabdomyolysis, Acute Kidney Injury and Beyond. PG - 122-130 LID - 10.1159/000517694 [doi] AB - Clinical Background: Automobile accidents constitute one of the main causes of morbidity and mortality worldwide. Kidney injury related to automobile accidents occurs through several mechanisms. Among the mechanisms are direct traumatic injury, rhabdomyolysis, acute renal failure, hypovolemic shock, and others. Kidney injuries after traffic accidents can have different forms of clinical presentation, which can include morphological and functional changes of the organ. Epidemiology: Annually, approximately 1.35 million individuals are fatal victims of motor vehicle accidents. Challenges: It is of the utmost importance to recognize and adequately manage kidney injuries secondary to automobile events, since their timely identification can prevent permanent damage to the organ and, at times, save lives. Prevention and Treatment: An approach with a focus on traffic safety is ideal for all users. The cornerstones of this approach are safe roads and road shoulders, adequate speeds, safe vehicles, and trained drivers. Kidney injury and death due to this condition can be prevented by effective and integrated traffic legislation. After the occurrence of traffic accidents, effective emergency care is vital. Thus, a series of urgent actions are essential to provide assistance to the injured individual. In patients who are victims of car accidents and develop acute kidney injury and rhabdomyolysis, a timely diagnosis is extremely important to be able to offer assistance to the patient still in the early stages. CI - © 2021 S. Karger AG, Basel. FAU - Camurça Fernandes, Paula Frassinetti Castelo Branco AU - Camurça Fernandes PFCB AD - Universidade Estadual do Ceará, Fortaleza, Brazil. AD - Hospital Universitário Walter Cantídio-HUWC-UFC, Fortaleza, Brazil. FAU - Gonçalves Lima Paiva, José Hícaro Hellano AU - Gonçalves Lima Paiva JHH AD - Universidade Estadual do Ceará, Fortaleza, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20210825 PL - Switzerland TA - Contrib Nephrol JT - Contributions to nephrology JID - 7513582 SB - IM MH - Accidents, Traffic MH - *Acute Kidney Injury/epidemiology/etiology/therapy MH - Humans MH - Kidney MH - Motor Vehicles MH - *Rhabdomyolysis/complications/therapy MH - *Wounds and Injuries/complications EDAT- 2021/08/26 06:00 MHDA- 2022/04/02 06:00 CRDT- 2021/08/25 20:12 PHST- 2020/10/28 00:00 [received] PHST- 2021/03/10 00:00 [accepted] PHST- 2021/08/26 06:00 [pubmed] PHST- 2022/04/02 06:00 [medline] PHST- 2021/08/25 20:12 [entrez] AID - 000517694 [pii] AID - 10.1159/000517694 [doi] PST - ppublish SO - Contrib Nephrol. 2021;199:122-130. doi: 10.1159/000517694. Epub 2021 Aug 25. PMID- 33053485 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210128 IS - 2210-2612 (Print) IS - 2210-2612 (Electronic) IS - 2210-2612 (Linking) VI - 76 DP - 2020 TI - Iatrogenic pneumopericardium after tube thoracostomy: A case report. PG - 259-262 LID - S2210-2612(20)30882-8 [pii] LID - 10.1016/j.ijscr.2020.10.006 [doi] AB - INTRODUCTION: Pneumopericardium, the presence of air within the pericardial space, is a rare occurrence which usually follows positive pressure ventilation in infants, or blunt and penetrating thoracoabdominal injuries in adults. The occurrence of iatrogenic pneumopericardium following tube thoracostomy is extremely rare. PRESENTATION OF CASE: We present a rare case of iatrogenic pneumopericardium in a 1 year and 7 months old female child for whom a left side tube thoracostomy was done using nasogastric tube for an indication of left empyema thoracis. Later, she developed progressively worsening shortness of breath and imaging revealed iatrogenic pneumopericardium. She was managed conservatively and discharged home in good condition. DISCUSSION: Iatrogenic pneumopericardium can have a range of presentations from being asymptomatic to features of cardiac tamponade. Patient management depends on the presence of tamponade effect and age of the patient. Infants tend to develop cardiac tamponade earlier urging surgical intervention but selected patients can be managed conservatively. CONCLUSION: Iatrogenic pneumopericardium is a rare event but it might lead to death if not diagnosed and treated promptly. Although the tendency to develop tension pneumopericardium urging surgical intervention is high in pediatric patients, our patient has improved well with conservative management. While reporting of complications is not popular, this represents an opportunity to advance the safety during chest drain insertion. CI - Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Mindaye, Esubalew Taddese AU - Mindaye ET AD - Department of Surgery, Saint Paul's Hospital Millennium Medical College, Swaziland Street 1271, Addis Ababa, Ethiopia. Electronic address: esubetad24@yahoo.com. FAU - Arayia, Abraham AU - Arayia A AD - Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Electronic address: abraham.ariaya@gmail.com. FAU - Tufa, Tesfaye H AU - Tufa TH AD - Department of Obstetrics and Gynecology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Electronic address: tesfaye.hurisa@sphmmc.edu.et. FAU - Bekele, Mahteme AU - Bekele M AD - Department of Surgery, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Electronic address: mahtemebekele@gmail.com. LA - eng PT - Case Reports PT - Journal Article DEP - 20201008 PL - Netherlands TA - Int J Surg Case Rep JT - International journal of surgery case reports JID - 101529872 PMC - PMC7566206 OTO - NOTNLM OT - Case report OT - Chest drain OT - Iatrogenic OT - Pneumopericardium EDAT- 2020/10/15 06:00 MHDA- 2020/10/15 06:01 PMCR- 2020/10/08 CRDT- 2020/10/14 20:07 PHST- 2020/08/19 00:00 [received] PHST- 2020/10/04 00:00 [revised] PHST- 2020/10/04 00:00 [accepted] PHST- 2020/10/15 06:00 [pubmed] PHST- 2020/10/15 06:01 [medline] PHST- 2020/10/14 20:07 [entrez] PHST- 2020/10/08 00:00 [pmc-release] AID - S2210-2612(20)30882-8 [pii] AID - 10.1016/j.ijscr.2020.10.006 [doi] PST - ppublish SO - Int J Surg Case Rep. 2020;76:259-262. doi: 10.1016/j.ijscr.2020.10.006. Epub 2020 Oct 8. PMID- 18161502 OWN - NLM STAT- MEDLINE DCOM- 20080225 LR - 20220419 IS - 1040-8444 (Print) IS - 1040-8444 (Linking) VI - 38 IP - 1 DP - 2008 TI - Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment. PG - 13-71 AB - Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has a proven safety record when appropriately applied to eliminate weeds. However, over the last decades, there have been numerous fatalities, mainly caused by accidental or voluntary ingestion. PQ poisoning is an extremely frustrating condition to manage clinically, due to the elevated morbidity and mortality observed so far and due to the lack of effective treatments to be used in humans. PQ mainly accumulates in the lung (pulmonary concentrations can be 6 to 10 times higher than those in the plasma), where it is retained even when blood levels start to decrease. The pulmonary effects can be explained by the participation of the polyamine transport system abundantly expressed in the membrane of alveolar cells type I, II, and Clara cells. Further downstream at the toxicodynamic level, the main molecular mechanism of PQ toxicity is based on redox cycling and intracellular oxidative stress generation. With this review we aimed to collect and describe the most pertinent and significant findings published in established scientific publications since the discovery of PQ, focusing on the most recent developments related to PQ lung toxicity and their relevance to the treatment of human poisonings. Considerable space is also dedicated to techniques for prognosis prediction, since these could allow development of rigorous clinical protocols that may produce comparable data for the evaluation of proposed therapies. FAU - Dinis-Oliveira, R J AU - Dinis-Oliveira RJ AD - REQUIMTE, Departamento de Toxicologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. ricardinis@sapo.pt FAU - Duarte, J A AU - Duarte JA FAU - Sánchez-Navarro, A AU - Sánchez-Navarro A FAU - Remião, F AU - Remião F FAU - Bastos, M L AU - Bastos ML FAU - Carvalho, F AU - Carvalho F LA - eng PT - Journal Article PT - Review PL - England TA - Crit Rev Toxicol JT - Critical reviews in toxicology JID - 8914275 RN - 0 (Herbicides) RN - PLG39H7695 (Paraquat) SB - IM MH - Animals MH - Herbicides/chemistry/pharmacokinetics/*poisoning MH - Humans MH - Lung/pathology/physiopathology MH - Lung Diseases/*chemically induced/pathology/physiopathology/*therapy MH - Paraquat/chemistry/pharmacokinetics/*poisoning MH - Treatment Outcome RF - 480 EDAT- 2007/12/29 09:00 MHDA- 2008/02/26 09:00 CRDT- 2007/12/29 09:00 PHST- 2007/12/29 09:00 [pubmed] PHST- 2008/02/26 09:00 [medline] PHST- 2007/12/29 09:00 [entrez] AID - 788999881 [pii] AID - 10.1080/10408440701669959 [doi] PST - ppublish SO - Crit Rev Toxicol. 2008;38(1):13-71. doi: 10.1080/10408440701669959. PMID- 35545555 OWN - NLM STAT- MEDLINE DCOM- 20220802 LR - 20220922 IS - 1880-8026 (Electronic) IS - 0019-8366 (Print) IS - 0019-8366 (Linking) VI - 60 IP - 4 DP - 2022 Jul 31 TI - Strategies to manage working from home during the pandemic: the employee experience. PG - 319-333 LID - 10.2486/indhealth.2022-0042 [doi] AB - Many Australian workers were mandated to work from home during the COVID-19 pandemic. Using a qualitative approach, this study aimed to identify optimal work from home management strategies, by analysing the experience of Australian employees working from home (WFH) during this time. A purposive sample, drawn from the Australian Employees Working from Home Study, of managers and non-managers from a range of sectors, was invited to participate in focus groups. Data were analysed using thematic analysis and mapped to the work-systems framework approach to determine strategies implemented to support WFH. Most participants' experiences were more negative than positive, in part due to extreme lockdowns including curfews, with childcare and school closures compounding their WFH experiences. Effective workplace-initiated strategies to optimise WFH included: management support of flexible work hours; provision of necessary equipment with ICT support; regular online communication; performance management adjustments; and manager training. FAU - Oakman, Jodi AU - Oakman J AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Kinsman, Natasha AU - Kinsman N AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Graham, Melissa AU - Graham M AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. AD - Department of Public Health, La Trobe University, Australia. FAU - Stuckey, Rwth AU - Stuckey R AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. FAU - Weale, Victoria AU - Weale V AD - Centre for Ergonomics and Human Factors, School of Psychology and Public Health, La Trobe University, Australia. LA - eng PT - Journal Article DEP - 20220511 PL - Japan TA - Ind Health JT - Industrial health JID - 2985065R SB - IM MH - Australia MH - *COVID-19/epidemiology MH - Communicable Disease Control MH - Humans MH - *Pandemics/prevention & control MH - Workplace PMC - PMC9453551 OTO - NOTNLM OT - Australian workforce OT - COVID-19 OT - Management OT - Wellbeing OT - Work health and Safety OT - Working from home COIS- The authors declare there are no conflicts of interest. EDAT- 2022/05/12 06:00 MHDA- 2022/08/03 06:00 PMCR- 2022/07/01 CRDT- 2022/05/11 22:13 PHST- 2022/05/12 06:00 [pubmed] PHST- 2022/08/03 06:00 [medline] PHST- 2022/05/11 22:13 [entrez] PHST- 2022/07/01 00:00 [pmc-release] AID - 2022-0042 [pii] AID - 10.2486/indhealth.2022-0042 [doi] PST - ppublish SO - Ind Health. 2022 Jul 31;60(4):319-333. doi: 10.2486/indhealth.2022-0042. Epub 2022 May 11. PMID- 11781937 OWN - NLM STAT- MEDLINE DCOM- 20020213 LR - 20190906 IS - 0022-0736 (Print) IS - 0022-0736 (Linking) VI - 34 Suppl DP - 2001 TI - Slow conduction in cardiac tissue: insights from optical mapping at the cellular level. PG - 57-64 AB - Under physiological conditions, slow conduction is essential for the function of the atrioventricular (AV) node, whereas, under pathophysiological conditions, slow conduction contributes importantly to the generation of life-threatening reentrant arrhythmias. This article addresses characteristics of slow conduction at the cellular network level during (a) a reduction of excitability, (b) a reduction of gap junctional coupling, and (c) in the setting of branching tissue structures. Microscopic impulse propagation in these settings was studied by using multiple site optical recording of transmembrane voltage in conjunction with patterned growth cultures of neonatal rat ventricular myocytes. In linear cell strands, a reduction of excitability slowed conduction by approximately 70% before block occurred. In contrast, critical reduction of gap junctional coupling induced a much higher degree of slowing (>99%) before block of conduction. Interestingly, a similar degree of conduction slowing was also observed in branching tissue structures under conditions of reduced excitability (98%). The finding of extremely slow but nevertheless safe conduction in these structures might be explained by a "pull and push" effect of the branches: by drawing electronic current from the activation wavefront, they first act as current loads which slow conduction at the branch points ("pull" effect). Then, on activation, they turn into current sources which feed current back into the system, thus supporting downstream activation and enhancing the safety of propagation ("push" effect). This "pull and push" mechanism may play a significant role in slow conduction in the AV node and in structurally discontinuous myocardium, such as the border regions of infarct scars. FAU - Kucera, J P AU - Kucera JP AD - Department of Physiology, University of Bern, Switzerland. FAU - Kléber, A G AU - Kléber AG FAU - Rohr, S AU - Rohr S LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Electrocardiol JT - Journal of electrocardiology JID - 0153605 SB - IM MH - Action Potentials MH - Animals MH - Animals, Newborn MH - Atrioventricular Node/physiology MH - Gap Junctions/physiology MH - Heart Conduction System/*physiology MH - Myocardium/cytology MH - Optics and Photonics MH - Rats EDAT- 2002/01/10 10:00 MHDA- 2002/02/14 10:01 CRDT- 2002/01/10 10:00 PHST- 2002/01/10 10:00 [pubmed] PHST- 2002/02/14 10:01 [medline] PHST- 2002/01/10 10:00 [entrez] AID - ajelc034b0057 [pii] AID - 10.1054/jelc.2001.28827 [doi] PST - ppublish SO - J Electrocardiol. 2001;34 Suppl:57-64. doi: 10.1054/jelc.2001.28827. PMID- 27367297 OWN - NLM STAT- MEDLINE DCOM- 20170227 LR - 20220409 IS - 1744-764X (Electronic) IS - 1474-0338 (Linking) VI - 15 IP - 10 DP - 2016 Oct TI - The safety of treatment options for pediatric Crohn's disease. PG - 1383-90 LID - 10.1080/14740338.2016.1203418 [doi] AB - INTRODUCTION: A severe clinical phenotype along with concern for ensuring normal growth and development has a major impact on treatment choices for children newly diagnosed with Crohn's disease (CD). AREAS COVERED: We review the increasingly outdated concept of 'conventional' therapy of pediatric CD based on aminosalicylates, corticosteroids, and immunomodulators for patients at high risk of complicated disease. Key safety concerns with each treatment are reviewed. EXPERT OPINION: There are minimal data supporting the use of aminosalicylates in the treatment of pediatric CD. Corticosteroids are effective short-term for improving signs and symptoms of disease but are ineffective for maintenance therapy. Thiopurines decrease corticosteroid dependence but may not alter progression to complicated disease requiring surgery. Concerns for lymphoma as well as hemophagocytic lymphohistiocytosis with thiopurines are valid. Further data are required on the efficacy and safety of methotrexate as an alternative immunomodulator. Though generally well tolerated and efficacious in most patients, anti-TNF-α therapy can be associated with both mild as well as more serious complications. Current data do not support an increased risk for malignancy associated with anti-TNF therapy alone in children. Anti-adhesion therapy appears to have a favorable safety profile but the experience in children is extremely limited. FAU - Grossi, Victoria AU - Grossi V AD - a Division of Digestive Diseases, Hepatology, and Nutrition , Connecticut Children's Medical Center , Hartford , CT , USA. FAU - Hyams, Jeffrey S AU - Hyams JS AD - a Division of Digestive Diseases, Hepatology, and Nutrition , Connecticut Children's Medical Center , Hartford , CT , USA. AD - b University of Connecticut School of Medicine , Farmington , CT , USA. LA - eng PT - Journal Article PT - Review DEP - 20160701 PL - England TA - Expert Opin Drug Saf JT - Expert opinion on drug safety JID - 101163027 RN - 0 (Aminosalicylic Acids) RN - 0 (Glucocorticoids) RN - 0 (Immunologic Factors) RN - 0 (Tumor Necrosis Factor-alpha) RN - YL5FZ2Y5U1 (Methotrexate) RN - Pediatric Crohn's disease SB - IM MH - Aminosalicylic Acids/adverse effects/therapeutic use MH - Child MH - Crohn Disease/*drug therapy/physiopathology MH - Disease Progression MH - Glucocorticoids/adverse effects/*therapeutic use MH - Humans MH - Immunologic Factors/adverse effects/*therapeutic use MH - Methotrexate/adverse effects/therapeutic use MH - Tumor Necrosis Factor-alpha/antagonists & inhibitors OTO - NOTNLM OT - Crohn’s OT - Thiopurines OT - children OT - infliximab EDAT- 2016/07/02 06:00 MHDA- 2017/02/28 06:00 CRDT- 2016/07/02 06:00 PHST- 2016/07/02 06:00 [entrez] PHST- 2016/07/02 06:00 [pubmed] PHST- 2017/02/28 06:00 [medline] AID - 10.1080/14740338.2016.1203418 [doi] PST - ppublish SO - Expert Opin Drug Saf. 2016 Oct;15(10):1383-90. doi: 10.1080/14740338.2016.1203418. Epub 2016 Jul 1. PMID- 26438325 OWN - NLM STAT- MEDLINE DCOM- 20161101 LR - 20220310 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) VI - 48 IP - 2 DP - 2016 Feb TI - Direct inhibition of plasmatic renin activity with aliskiren: a promising but under-investigated therapeutic option for non-diabetic glomerulonephritis. PG - 229-37 LID - 10.1007/s11255-015-1128-4 [doi] AB - Non-diabetic glomerulonephritis is a frequent cause of end-stage renal disease. The use of renin-angiotensin-aldosterone system blockers is a fundamental therapeutic approach. However, converting enzyme inhibitors (ACE-is) and angiotensin receptor blockers do not always achieve the desired target of proteinuria. The induction of the prorenin and renin up-regulation is a possible explanation. Aliskiren is the first drug acting as direct inhibitor of plasmatic renin activity, also able to interfere with the prorenin and renin profibrotic escape. We aimed at reviewing the literature for the assessment of potential efficacy and safety of aliskiren in the treatment of non-diabetic glomerulonephritis. The data on this topic are limited; however, we concluded for a possible usefulness of aliskiren. The renal safety profile appears potentially acceptable in non-diabetic patients although extreme carefulness, particularly with respect to long-term renal and cardiovascular tolerability, is recommended. FAU - Simeoni, Mariadelina AU - Simeoni M AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. adelina_simeoni@yahoo.it. FAU - Nicotera, Ramona AU - Nicotera R AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Colao, Maria AU - Colao M AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Citraro, Maria Lucia AU - Citraro ML AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Pelagi, Elena AU - Pelagi E AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Cerantonio, Annamaria AU - Cerantonio A AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Comi, Nicola AU - Comi N AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Coppolino, Giuseppe AU - Coppolino G AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. FAU - Fuiano, Giorgio AU - Fuiano G AD - Nephrology and Dialysis Unit, University-Hospital "Magna Graecia" of Catanzaro, Viale Europa, 88100, Catanzaro, Italy. LA - eng PT - Journal Article PT - Review DEP - 20151005 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 RN - 0 (Amides) RN - 0 (Fumarates) RN - 502FWN4Q32 (aliskiren) RN - EC 3.4.23.15 (Renin) SB - IM MH - Amides/*pharmacology MH - Diabetes Mellitus MH - Fumarates/*pharmacology MH - Glomerulonephritis/complications/*drug therapy MH - Humans MH - Kidney Failure, Chronic/etiology/*prevention & control MH - Renin/*antagonists & inhibitors/blood MH - Treatment Outcome OTO - NOTNLM OT - Aliskiren OT - Chronic kidney disease OT - Glomerulonephritis OT - Intrarenal RAAS OT - Non-diabetic EDAT- 2015/10/07 06:00 MHDA- 2016/11/02 06:00 CRDT- 2015/10/07 06:00 PHST- 2015/04/27 00:00 [received] PHST- 2015/09/25 00:00 [accepted] PHST- 2015/10/07 06:00 [entrez] PHST- 2015/10/07 06:00 [pubmed] PHST- 2016/11/02 06:00 [medline] AID - 10.1007/s11255-015-1128-4 [pii] AID - 10.1007/s11255-015-1128-4 [doi] PST - ppublish SO - Int Urol Nephrol. 2016 Feb;48(2):229-37. doi: 10.1007/s11255-015-1128-4. Epub 2015 Oct 5. PMID- 12632641 OWN - NLM STAT- MEDLINE DCOM- 20030404 LR - 20080310 IS - 0043-3144 (Print) IS - 0043-3144 (Linking) VI - 51 IP - 4 DP - 2002 Dec TI - Preoperative starvation and pulmonary aspiration. New perspectives and guidelines. PG - 241-5 AB - The fear of aspiration of gastric contents and its life-threatening consequences in patients(aspiration pneumonitis and respiratory failure), has caused many medical practitioners, particularly anaesthetists, to rigidly follow conservative (i.e. prolonged) preoperative fasting standards. This is the nil per os (NPO) order for clear fluids/liquids and solids overnight or six to eight hours preceding the induction of anaesthesia. This practice neither takes into account the differences in the rate of gastric emptying for solid food (which may exceed six hours) and clear liquids (which is one to two hours), nor the differences in scheduled times of surgery. Long-term prospective studies and retrospective reviews have shown that the incidence of significant clinical aspiration is low: 1.4-6.0 per 100,00 anaesthetics for elective general surgery. Risk factors for pulmonary aspiration include: a high American Society of Anaesthesiologists (ASA) physical status score; emergency surgery; difficult airway management; increased gastric volume and acidity; increased intra-abdominal pressure; gastro-oesophageal reflux; oesophageal disease; head injury with impaired consciousness and extremes of age. Experimental studies and reviews have consistently shown the safety of clear liquid ingestion up to two hours before induction of anaesthesia in healthy patients without risk factors, and the fact that a longer fluid fast does not necessarily offer any added protection against pulmonary aspiration. The conservative pre-operative fasting standard causes discomfort and in some cases, suffering of patients and is therefore unnecessary for patients without risk factor(s). Anecdotal reports at the University Hospital of the West Indies (UHWI) have shown that application of the liberalized guidelines for preoperative fasting and fluid intake has not resulted in increased pulmonary aspiration, morbidity or mortality. Instead it has resulted in decreased irritability, anxiety, thirst and hunger in the peri-operative period. Patients, especially children are more comfortable and the perioperative period is better tolerated. It is therefore time that all medical personnel adopt the liberalized guidelines. FAU - Scarlett, M AU - Scarlett M AD - Department of Surgery, Radiology, Anaesthesia and Intensive Care, University of the West Indies, Kingston 7, Jamaica. mdscarl@yahoo.com FAU - Crawford-Sykes, A AU - Crawford-Sykes A FAU - Nelson, M AU - Nelson M LA - eng PT - Journal Article PT - Review PL - Jamaica TA - West Indian Med J JT - The West Indian medical journal JID - 0417410 SB - IM MH - *Fasting MH - Humans MH - Intraoperative Complications/*prevention & control MH - Pneumonia, Aspiration/*prevention & control MH - Preoperative Care/*standards RF - 52 EDAT- 2003/03/14 04:00 MHDA- 2003/04/05 05:00 CRDT- 2003/03/14 04:00 PHST- 2003/03/14 04:00 [pubmed] PHST- 2003/04/05 05:00 [medline] PHST- 2003/03/14 04:00 [entrez] PST - ppublish SO - West Indian Med J. 2002 Dec;51(4):241-5. PMID- 34207622 OWN - NLM STAT- MEDLINE DCOM- 20210706 LR - 20210706 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 12 DP - 2021 Jun 9 TI - Patch-Type Vibration Visualization (PVV) Sensor System Based on Triboelectric Effect. LID - 10.3390/s21123976 [doi] LID - 3976 AB - Self-powered wireless sensor systems have emerged as an important topic for condition monitoring in nuclear power plants. However, commercial wireless sensor systems still cannot be fully self-sustainable due to the high power consumption caused by excessive signal processing in a mini-electronic computing system. In this sense, it is essential not only to integrate the sensor system with energy-harvesting devices but also to develop simple data processing methods for low power schemes. In this paper, we report a patch-type vibration visualization (PVV) sensor system based on the triboelectric effect and a visualization technique for self-sustainable operation. The PVV sensor system composed of a polyethylene terephthalate (PET)/Al/LCD screen directly converts the triboelectric signal into an informative black pattern on the LCD screen without excessive signal processing, enabling extremely low power operation. In addition, a proposed image processing method reconverts the black patterns to frequency and acceleration values through a remote-control camera. With these simple signal-to-pattern conversion and pattern-to-data reconversion techniques, a vibration visualization sensor network has successfully been demonstrated. FAU - Kim, Sun-Jin AU - Kim SJ AUID- ORCID: 0000-0002-5738-416X AD - Smart Structural Safety and Prognosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero 989Beon-gil, Yuseong-gu, Daejeon 34057, Korea. FAU - Seol, Myeong-Lok AU - Seol ML AD - Center for Nanotechnology and Universities Space Research Association, NASA Ames Research Center, Moffett Field, CA 94035, USA. FAU - Chung, Byun-Young AU - Chung BY AD - Smart Structural Safety and Prognosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero 989Beon-gil, Yuseong-gu, Daejeon 34057, Korea. FAU - Jang, Dae-Sic AU - Jang DS AD - Smart Structural Safety and Prognosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero 989Beon-gil, Yuseong-gu, Daejeon 34057, Korea. FAU - Kim, Jong-Hwan AU - Kim JH AD - Smart Structural Safety and Prognosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero 989Beon-gil, Yuseong-gu, Daejeon 34057, Korea. FAU - Choi, Young-Chul AU - Choi YC AD - Smart Structural Safety and Prognosis Research Division, Korea Atomic Energy Research Institute, 111 Daedeok-daero 989Beon-gil, Yuseong-gu, Daejeon 34057, Korea. LA - eng GR - NRF-2020M2C9A1062710/National Research Foundation of Korea/ PT - Journal Article DEP - 20210609 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Electric Power Supplies MH - Electronics MH - *Nanotechnology MH - Signal Processing, Computer-Assisted MH - Vibration PMC - PMC8227292 OTO - NOTNLM OT - condition monitoring OT - pattern-to-data decoding OT - self-sustainable vibration visualization sensor system OT - signal-to-pattern encoding OT - triboelectric effect COIS- The authors declare no conflict of interest. EDAT- 2021/07/03 06:00 MHDA- 2021/07/07 06:00 PMCR- 2021/06/09 CRDT- 2021/07/02 01:32 PHST- 2021/05/17 00:00 [received] PHST- 2021/06/06 00:00 [revised] PHST- 2021/06/07 00:00 [accepted] PHST- 2021/07/02 01:32 [entrez] PHST- 2021/07/03 06:00 [pubmed] PHST- 2021/07/07 06:00 [medline] PHST- 2021/06/09 00:00 [pmc-release] AID - s21123976 [pii] AID - sensors-21-03976 [pii] AID - 10.3390/s21123976 [doi] PST - epublish SO - Sensors (Basel). 2021 Jun 9;21(12):3976. doi: 10.3390/s21123976. PMID- 19050347 OWN - NLM STAT- MEDLINE DCOM- 20090112 LR - 20191210 IS - 1344-6304 (Print) IS - 1344-6304 (Linking) VI - 61 IP - 6 DP - 2008 Nov TI - Current risks in blood transfusion in Japan. PG - 427-33 AB - Over the past decades, the incidence of transfusion-transmitted diseases has been dramatically reduced. These reductions have been due to a multifocal approach to the collection, processing, and release of blood components. The estimated risks of transfusion-transmitted hepatitis viruses are now extremely small, but the possibility of infections with emerging pathogens always exists because preventive measures may not be available for all cases. Thus, some patients may be harmed before preventive measures are introduced. Beside transfusion-transmitted infections (TTI), unsolved residual risks such as transfusion-related acute lung injury or incompatible blood components transfusion still exist as major concerns. Continuous efforts toward research on and the prevention of adverse reaction-related blood components must be made to ensure blood safety. The purpose of this article is to introduce the concept of the current risks of transfusion including TTI, review the preventive measures already implemented, and discuss future visions for transfusion safety in Japan. FAU - Otsubo, Hiroko AU - Otsubo H AD - Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo, Japan. FAU - Yamaguchi, Kazunari AU - Yamaguchi K LA - eng PT - Journal Article PT - Review PL - Japan TA - Jpn J Infect Dis JT - Japanese journal of infectious diseases JID - 100893704 SB - IM MH - Blood Group Incompatibility/*prevention & control MH - Blood Transfusion/*standards MH - Graft vs Host Disease/*prevention & control MH - Humans MH - Infections/microbiology/*transmission/virology MH - Risk MH - *Transfusion Reaction RF - 66 EDAT- 2008/12/04 09:00 MHDA- 2009/01/13 09:00 CRDT- 2008/12/04 09:00 PHST- 2008/12/04 09:00 [pubmed] PHST- 2009/01/13 09:00 [medline] PHST- 2008/12/04 09:00 [entrez] PST - ppublish SO - Jpn J Infect Dis. 2008 Nov;61(6):427-33. PMID- 16041014 OWN - NLM STAT- MEDLINE DCOM- 20050826 LR - 20181113 IS - 0019-9567 (Print) IS - 1098-5522 (Electronic) IS - 0019-9567 (Linking) VI - 73 IP - 8 DP - 2005 Aug TI - Characterization of enterohemorrhagic Escherichia coli strains based on acid resistance phenotypes. PG - 4993-5003 AB - Acid resistance is perceived to be an important property of enterohemorrhagic Escherichia coli strains, enabling the organisms to survive passage through the acidic environment of the stomach so that they may colonize the mammalian gastrointestinal tract and cause disease. Accordingly, the organism has developed at least three genetically and physiologically distinct acid resistance systems which provide different levels of protection. The glutamate-dependent acid resistance (GDAR) system utilizes extracellular glutamate to protect cells during extreme acid challenges and is believed to provide the highest protection from stomach acidity. In this study, the GDAR system of 82 pathogenic E. coli isolates from 34 countries and 23 states within the United States was examined. Twenty-nine isolates were found to be defective in inducing GDAR under aerobic growth conditions, while five other isolates were defective in GDAR under aerobic, as well as fermentative, growth conditions. We introduced rpoS on a low-copy-number plasmid into 26 isolates and were able to restore GDAR in 20 acid-sensitive isolates under aerobic growth conditions. Four isolates were found to be defective in the newly discovered LuxR-like regulator GadE (formerly YhiE). Defects in other isolates could be due to a mutation(s) in a gene(s) with an as yet undefined role in acid resistance since GadE and/or RpoS could not restore acid resistance. These results show that in addition to mutant alleles of rpoS, mutations in gadE exist in natural populations of pathogenic E. coli. Such mutations most likely alter the infectivity of individual isolates and may play a significant role in determining the infective dose of enterohemorrhagic E. coli. FAU - Bhagwat, Arvind A AU - Bhagwat AA AD - Produce Quality and Safety Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Bldg. 002, 10300 Baltimore Avenue, Beltsville, MD 20705-2350, USA. bhagwata@ba.ars.usda.gov FAU - Chan, Lynn AU - Chan L FAU - Han, Rachel AU - Han R FAU - Tan, Jasmine AU - Tan J FAU - Kothary, Mahendra AU - Kothary M FAU - Jean-Gilles, Junia AU - Jean-Gilles J FAU - Tall, Ben D AU - Tall BD LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Infect Immun JT - Infection and immunity JID - 0246127 RN - 0 (Bacterial Proteins) RN - 0 (Culture Media) RN - 0 (Escherichia coli Proteins) RN - 0 (GadE protein, E coli) RN - 0 (Sigma Factor) RN - 0 (Transcription Factors) RN - 0 (sigma factor KatF protein, Bacteria) RN - 3KX376GY7L (Glutamic Acid) RN - EC 4.1.1.15 (Glutamate Decarboxylase) SB - IM MH - Bacterial Adhesion/physiology MH - Bacterial Proteins/metabolism MH - Caco-2 Cells MH - Culture Media MH - Escherichia coli/genetics/*metabolism MH - Escherichia coli Proteins/metabolism MH - Gene Expression Profiling MH - Glutamate Decarboxylase/genetics/metabolism MH - Glutamic Acid/*metabolism MH - Hot Temperature MH - Humans MH - Hydrogen-Ion Concentration MH - Sigma Factor/metabolism MH - Time Factors MH - Transcription Factors/deficiency/metabolism PMC - PMC1201262 EDAT- 2005/07/26 09:00 MHDA- 2005/08/27 09:00 PMCR- 2005/08/01 CRDT- 2005/07/26 09:00 PHST- 2005/07/26 09:00 [pubmed] PHST- 2005/08/27 09:00 [medline] PHST- 2005/07/26 09:00 [entrez] PHST- 2005/08/01 00:00 [pmc-release] AID - 73/8/4993 [pii] AID - 2069-04 [pii] AID - 10.1128/IAI.73.8.4993-5003.2005 [doi] PST - ppublish SO - Infect Immun. 2005 Aug;73(8):4993-5003. doi: 10.1128/IAI.73.8.4993-5003.2005. PMID- 35070524 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231103 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 13 IP - 12 DP - 2021 Dec TI - A Case of Hepatotoxicity After Receiving a COVID-19 Vaccine. PG - e20455 LID - 10.7759/cureus.20455 [doi] LID - e20455 AB - The coronavirus disease 2019 (COVID-19) has led to a global health crisis. Its clinical manifestations are well-documented, and severe complications among patients who survived the infection are being continuously reported. Several vaccines with well-established efficacies and excellent safety profiles have also been approved. To date, few side effects of vaccines have been reported. Drug-induced hepatotoxicity is an extremely rare side effect of these vaccines, with few reported instances. In this case report, we describe a patient who experienced hepatotoxicity after receiving the COVID-19 vaccine from Pfizer BioNTech. CI - Copyright © 2021, Alqarni et al. FAU - Alqarni, Muath M AU - Alqarni MM AD - Department of Medicine, Umm Alqura University, Makkah, SAU. FAU - Faloudah, Ammar Z AU - Faloudah AZ AD - Department of Medicine, Umm Alqura University, Makkah, SAU. FAU - Alsulaihebi, Amjad S AU - Alsulaihebi AS AD - Department of Medicine, Umm Alqura University, Makkah, SAU. FAU - Halawani, Hassan K AU - Halawani HK AD - Department of Medicine, Umm Alqura University, Makkah, SAU. FAU - Khan, Abdulmajeed S AU - Khan AS AD - Department of Internal Medicine, Hera General Hospital, Makkah, SAU. LA - eng PT - Case Reports PT - Journal Article DEP - 20211216 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC8760787 OTO - NOTNLM OT - coronavirus disease OT - covid19 vaccine OT - drug-induced acute liver failure OT - hepatotoxicity OT - vaccine side effects COIS- The authors have declared that no competing interests exist. EDAT- 2022/01/25 06:00 MHDA- 2022/01/25 06:01 PMCR- 2021/12/16 CRDT- 2022/01/24 08:52 PHST- 2021/12/16 00:00 [accepted] PHST- 2022/01/24 08:52 [entrez] PHST- 2022/01/25 06:00 [pubmed] PHST- 2022/01/25 06:01 [medline] PHST- 2021/12/16 00:00 [pmc-release] AID - 10.7759/cureus.20455 [doi] PST - epublish SO - Cureus. 2021 Dec 16;13(12):e20455. doi: 10.7759/cureus.20455. eCollection 2021 Dec. PMID- 35685855 OWN - NLM STAT- MEDLINE DCOM- 20220613 LR - 20220716 IS - 2778-2034 (Electronic) IS - 2778-2034 (Print) IS - 2778-2034 (Linking) VI - 1 IP - 4 DP - 2021 Dec 31 TI - [Medico-Surgical treatment of mycetoma in the Somine Dolo hospital of Mopti (Mali)]. LID - mtsi.2021.170 [pii] LID - 10.48327/mtsi.2021.170 [doi] AB - OBJECTIVE: The objective of this study was to describe the epidemiological and clinical aspects as well as the therapeutic methods of mycetomical lesions. MATERIAL AND METHODS: This was a longitudinal retrospective study, which included all patients treated for mycetoma from January 2016 to December 2018 including two years of recruitment and one year of monitoring (2019). The study concerned 19 patients who were hospitalized and treated in the department of surgery. RESULTS: Patients represented 2.3% of hospitalizations and consisted of 11 males and 8 females with an average age of 38 years with extremes of 15 - 70 years, and an average time between the onset of symptoms and presentation to the hospital of 10 years (range 1 - 40 years). Eight livestock breeders and seven farmers were concerned, 14 of whom have started the disease after trauma. The foot was involved in 13 patients. Twelve suffered from osteoarticular lesions. Black grains were present in 16 cases attributed to Madurella sp. We performed 12 amputations, six carcinological ablation to which specific local treatments were added (thin skin graft in two patients, fasciocutaneous flap in one patient and directed healing in the others) and local treatment in the last case. CONCLUSION: Mycetoma should be discussed and diagnosed at an early stage in predisposed patients particularly in farmers and breeders. Prevention is necessary; it is based on wound disinfection and wearing safety shoes. CI - Copyright © 2021 SFMTSI. FAU - Traore, Terna AU - Traore T AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Sikasso, Mali. FAU - Toure, Layes AU - Toure L AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Sikasso, Mali. FAU - Diassana, Mathias AU - Diassana M AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Mopti, Mali. FAU - Niang, Mamadou AU - Niang M AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Sikasso, Mali. FAU - Ballo, Emmanuel AU - Ballo E AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Sikasso, Mali. FAU - S Coulibaly, Boubacar AU - S Coulibaly B AD - Service d'orthopédie-traumatologie, établissement public hospitalier de Sikasso, Mali. FAU - Hans-Moevi, Aristote AU - Hans-Moevi A AD - Service d'orthopédie-traumatologie, Centre National Hospitalier Universitaire Hubert Koutougou MAGA de Cotonou (CNHU-HKM), Bénin. LA - fre PT - Journal Article TT - Prise en charge médico-chirurgicale des mycétomes à l'hôpital Somine Dolo de Mopti (Mali). DEP - 20211110 PL - France TA - Med Trop Sante Int JT - Medecine tropicale et sante internationale JID - 9918227363206676 SB - IM MH - Adolescent MH - Adult MH - Animals MH - Child MH - Child, Preschool MH - *Coleoptera MH - Female MH - Hospitals MH - Humans MH - Infant MH - *Madurella MH - Male MH - Mali MH - *Mycetoma/epidemiology MH - Retrospective Studies MH - Young Adult PMC - PMC9128469 OTO - NOTNLM OT - Actinomycetoma OT - Eumycetoma OT - Hospital OT - Madurella OT - Mali OT - Medico-surgical treatment OT - Mopti OT - Mycetoma OT - Sub-Saharan Africa EDAT- 2022/06/11 06:00 MHDA- 2022/06/14 06:00 PMCR- 2021/11/10 CRDT- 2022/06/10 02:36 PHST- 2020/12/01 00:00 [received] PHST- 2021/10/25 00:00 [accepted] PHST- 2022/06/10 02:36 [entrez] PHST- 2022/06/11 06:00 [pubmed] PHST- 2022/06/14 06:00 [medline] PHST- 2021/11/10 00:00 [pmc-release] AID - mtsi.2021.170 [pii] AID - 10.48327/mtsi.2021.170 [doi] PST - epublish SO - Med Trop Sante Int. 2021 Nov 10;1(4):mtsi.2021.170. doi: 10.48327/mtsi.2021.170. eCollection 2021 Dec 31. PMID- 34130056 OWN - NLM STAT- MEDLINE DCOM- 20210824 LR - 20240908 IS - 1879-2057 (Electronic) IS - 0001-4575 (Print) IS - 0001-4575 (Linking) VI - 159 DP - 2021 Sep TI - Speeding through the pandemic: Perceptual and psychological factors associated with speeding during the COVID-19 stay-at-home period. PG - 106225 LID - S0001-4575(21)00256-6 [pii] LID - 10.1016/j.aap.2021.106225 [doi] AB - During the COVID-19 stay-at-home period there were observed increases in both the percentage of cars engaged in extreme speeding, and the percentage of cars traveling below the speed limit. These changes have been attributed to unusually low traffic volume during the stay-at-home period. We develop a novel theoretical account, based on existing empirical research, of perceptual and psychological processes that may account for changes in speeding behavior under low traffic volume conditions. These include impaired ability to accurately perceive and control speed due to change in visual information, decreased salience of certain norms about socially appropriate speeds, lower perceived risk of speeding, and increased boredom leading to risk-taking behaviors. Further, we consider that individual attitude functions may account for the observed split in speeding behavior. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Tucker, A AU - Tucker A AD - Conecticut Transportation Safety Research Center, Storrs Mansfield, CT, USA. Electronic address: andrew.tucker@uconn.edu. FAU - Marsh, K L AU - Marsh KL AD - University of Connecticut Psychological Sciences Department, USA. LA - eng PT - Journal Article DEP - 20210612 PL - England TA - Accid Anal Prev JT - Accident; analysis and prevention JID - 1254476 SB - IM MH - Accidents, Traffic MH - *Automobile Driving MH - *COVID-19 MH - Humans MH - Pandemics MH - Risk-Taking MH - SARS-CoV-2 PMC - PMC9746225 OTO - NOTNLM OT - COVID-19 OT - Motivation OT - Perception OT - Speeding COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2021/06/16 06:00 MHDA- 2021/08/25 06:00 PMCR- 2021/06/12 CRDT- 2021/06/15 20:16 PHST- 2020/08/17 00:00 [received] PHST- 2021/05/07 00:00 [revised] PHST- 2021/06/01 00:00 [accepted] PHST- 2021/06/16 06:00 [pubmed] PHST- 2021/08/25 06:00 [medline] PHST- 2021/06/15 20:16 [entrez] PHST- 2021/06/12 00:00 [pmc-release] AID - S0001-4575(21)00256-6 [pii] AID - 106225 [pii] AID - 10.1016/j.aap.2021.106225 [doi] PST - ppublish SO - Accid Anal Prev. 2021 Sep;159:106225. doi: 10.1016/j.aap.2021.106225. Epub 2021 Jun 12. PMID- 33005801 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201003 IS - 2405-8440 (Print) IS - 2405-8440 (Electronic) IS - 2405-8440 (Linking) VI - 6 IP - 9 DP - 2020 Sep TI - Rainwater chemistry of acid precipitation occurrences due to long-range transboundary haze pollution and prolonged drought events during southwest monsoon season: climate change driven. PG - e04997 LID - 10.1016/j.heliyon.2020.e04997 [doi] LID - e04997 AB - The purposes of this research were to study the characteristics chemistry of pH, anions and cations in rainwater, and to identify the possible sources that contributing to the acid precipitation during southwest monsoon season with occurrence of extreme drought event. During the southwest monsoon season, it normally occurs along with haze phenomenon that every year will hit Southeast Asia. This condition will aggravate with high acidic particles in the atmosphere due to the prolonged drought. The analysed parameters which involved pH, anions (NO(3) (-), SO(4) (2-) and Cl(-)) and cations (Ca(2+), Mg(2+), Na(+) and K(+)) were analysed using pH meter, Hach DR 2800, argentometric method and ICP-OES. From the findings, it showed that acid rain occurred during the southwest monsoon season with the range of pH values from 4.95 ± 0.13 to 6.40 ± 0.03 and the total average of pH 5.71 ± 0.32. Anions NO(3) (-), SO(4) (2-) and Cl(-) were found to be the dominant compositions of the acid rain occurrences with higher concentrations detected. In overall, rural area recorded with higher acidity of precipitation at total average of pH 5.54 ± 0.39 compared to urban area at pH 5.77 ± 0.26. Rural area surprisingly recorded higher frequency occurrences of acid rain with pH lesser than 5.6 and below compared to urban area. As for public health and safety, all rainwater samples during the acid rain event were found exceeded the allowable limits of NWQS and WHO standards, that shown not suitable for skin contact, recreational purposes even for drinking purposes. CI - © 2020 The Authors. Published by Elsevier Ltd. FAU - Payus, C M AU - Payus CM AD - Institute for the Future Initiatives, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan. AD - Faculty of Science & Natural Resources, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia. AD - Institute for the Advanced Study of Sustainability, United Nations University, 5-53-70, Shibuya-ku, Tokyo, 150-8925, Japan. FAU - Jikilim, C AU - Jikilim C AD - Faculty of Science & Natural Resources, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia. FAU - Sentian, J AU - Sentian J AD - Faculty of Science & Natural Resources, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia. LA - eng PT - Journal Article DEP - 20200921 PL - England TA - Heliyon JT - Heliyon JID - 101672560 PMC - PMC7511740 OTO - NOTNLM OT - Acid rain OT - Atmospheric chemistry OT - Atmospheric science OT - Climate change OT - Climatology OT - Drought OT - Environmental analysis OT - Environmental assessment OT - Environmental impact assessment OT - Environmental management OT - Environmental pollution OT - Environmental science OT - Haze OT - Precipitation OT - Southwest monsoon EDAT- 2020/10/03 06:00 MHDA- 2020/10/03 06:01 PMCR- 2020/09/21 CRDT- 2020/10/02 05:46 PHST- 2020/07/16 00:00 [received] PHST- 2020/09/07 00:00 [revised] PHST- 2020/09/17 00:00 [accepted] PHST- 2020/10/02 05:46 [entrez] PHST- 2020/10/03 06:00 [pubmed] PHST- 2020/10/03 06:01 [medline] PHST- 2020/09/21 00:00 [pmc-release] AID - S2405-8440(20)31840-5 [pii] AID - e04997 [pii] AID - 10.1016/j.heliyon.2020.e04997 [doi] PST - epublish SO - Heliyon. 2020 Sep 21;6(9):e04997. doi: 10.1016/j.heliyon.2020.e04997. eCollection 2020 Sep. PMID- 16466293 OWN - NLM STAT- MEDLINE DCOM- 20060425 LR - 20191210 IS - 1744-8360 (Electronic) IS - 1473-7175 (Linking) VI - 6 IP - 2 DP - 2006 Feb TI - Bipolar disorder: historic perspective, current pharmacologic treatment options and a review of quetiapine. PG - 131-44 AB - Bipolar disorder is a complex mental illness that is frequently both under-diagnosed and under-treated. The symptoms of bipolar disorder can be confused with other medical illnesses or drug effects or may even be overlooked entirely as extreme character traits. The consequences of delayed diagnosis or misdiagnosis are potentially devastating, including loss of employment, impaired relationships and a severely impaired quality of life. This article will review the historic perspectives of bipolar disorder, the diagnostic criteria for the phases of the illness, and the pharmacologic options available to treat this condition. Quetiapine, an atypical antipsychotic, will be reviewed indepth. Based on extensive trial data, reviewed in this article, quetiapine is approved by the US Food and Drug Administration for use as monotherapy or as adjunctive therapy with other mood stabilizers for the treatment of acute manic episodes of bipolar I disorder. Clinical trials describing the efficacy of quetiapine in other phases of bipolar disorder and in other patient populations are also reviewed. A discussion of the drug profile of quetiapine includes its chemistry, availability, pharmacodynamics, pharmacokinetics and metabolism. Preclinical studies, postmarketing surveillance, safety, tolerability and regulatory issues are also evaluated. Finally, potential future directions for quetiapine are discussed, together with a review of key issues in bipolar disorder management and details of the information resources used in preparing this article. FAU - Khouzam, Hani Raoul AU - Khouzam HR AD - Chemical Dependency Treatment Program, Department of Psychiatry, VA Central California Healthcare System, Fresno, CA 93703-2286, USA. hani.khouzam2@.va.gov FAU - Singh, Fiza AU - Singh F LA - eng PT - Evaluation Study PT - Historical Article PT - Journal Article PT - Review PL - England TA - Expert Rev Neurother JT - Expert review of neurotherapeutics JID - 101129944 RN - 0 (Antidepressive Agents) RN - 0 (Antipsychotic Agents) RN - 0 (Dibenzothiazepines) RN - 0 (Lipids) RN - 2S3PL1B6UJ (Quetiapine Fumarate) SB - IM MH - Antidepressive Agents/*therapeutic use MH - Antipsychotic Agents/pharmacology/*therapeutic use MH - Bipolar Disorder/classification/*drug therapy/epidemiology/history MH - Dibenzothiazepines/pharmacology/*therapeutic use MH - Drug Monitoring MH - Drug Therapy, Combination MH - Drug and Narcotic Control MH - Expert Testimony MH - History, 19th Century MH - History, 20th Century MH - History, 21st Century MH - Humans MH - Hyperglycemia MH - Lipids/blood MH - Quetiapine Fumarate RF - 86 EDAT- 2006/02/10 09:00 MHDA- 2006/04/28 09:00 CRDT- 2006/02/10 09:00 PHST- 2006/02/10 09:00 [pubmed] PHST- 2006/04/28 09:00 [medline] PHST- 2006/02/10 09:00 [entrez] AID - 10.1586/14737175.6.2.131 [doi] PST - ppublish SO - Expert Rev Neurother. 2006 Feb;6(2):131-44. doi: 10.1586/14737175.6.2.131. PMID- 23996913 OWN - NLM STAT- MEDLINE DCOM- 20150106 LR - 20220408 IS - 1522-726X (Electronic) IS - 1522-1946 (Linking) VI - 83 IP - 6 DP - 2014 May 1 TI - Safety and efficacy metrics for primary nitinol stenting in femoropopliteal occlusive disease: a meta-analysis and critical examination of current methodologies. PG - 975-83 LID - 10.1002/ccd.25179 [doi] AB - BACKGROUND: The efficacy and safety of primary stenting for superficial femoral artery (SFA) disease have been benchmarked against historically derived performance goals. However, contemporary evidence evaluating SFA stenting is accumulating. The objective of this systematic review and meta-analysis was to quantitatively assess outcomes after primary SFA stenting with nitinol stents in contemporary practice, to compare these rates with commonly used efficacy and safety goals, and to discuss the clinical and regulatory implications of these findings. METHODS AND RESULTS: We searched MEDLINE, the US Food and Drug Administration (FDA) website, reference lists of qualifying articles, and conference proceedings until October 2012. Studies prospectively assessing primary nitinol stenting for diseased SFA were sought. Data from 11 prospective clinical trials were included. The twelve-month primary patency (PP) rate was reported in five trials. The meta-analytic 12-month PP rate was 71.6% (95% confidence interval [CI] 66.4-76.7%). The meta-analytic rate of 30-day freedom from a composite of death, target limb amputation, and reintervention was 99.9% (95% CI 100.0-90.0%). CONCLUSION: Contemporary nitinol-based bare-metal stents performed well in controlled settings. Occurrence of the 1-month composite safety endpoint was extremely uncommon. CI - Copyright © 2013 Wiley Periodicals, Inc. FAU - Vardi, Moshe AU - Vardi M AD - Harvard Clinical Research Institute, Boston, Massachusetts. FAU - Novack, Victor AU - Novack V FAU - Pencina, Michael J AU - Pencina MJ FAU - Doros, Gheorghe AU - Doros G FAU - Burke, David A AU - Burke DA FAU - Elmariah, Sammy AU - Elmariah S FAU - Cutlip, Donald E AU - Cutlip DE FAU - Mauri, Laura AU - Mauri L FAU - Yeh, Robert W AU - Yeh RW LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20140131 PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 RN - 0 (Alloys) RN - 2EWL73IJ7F (nitinol) SB - IM CIN - Catheter Cardiovasc Interv. 2014 May 1;83(6):984-6. doi: 10.1002/ccd.25221. PMID: 24285586 MH - *Alloys MH - Constriction, Pathologic MH - Endovascular Procedures/adverse effects/*instrumentation MH - *Femoral Artery/physiopathology MH - Humans MH - Peripheral Arterial Disease/diagnosis/physiopathology/*therapy MH - *Popliteal Artery/physiopathology MH - Prosthesis Design MH - Risk Factors MH - *Stents MH - Treatment Outcome MH - Vascular Patency OTO - NOTNLM OT - peripheral vascular disease OT - restenosis OT - stent structure EDAT- 2013/09/03 06:00 MHDA- 2015/01/07 06:00 CRDT- 2013/09/03 06:00 PHST- 2013/07/26 00:00 [received] PHST- 2013/08/25 00:00 [accepted] PHST- 2013/09/03 06:00 [entrez] PHST- 2013/09/03 06:00 [pubmed] PHST- 2015/01/07 06:00 [medline] AID - 10.1002/ccd.25179 [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2014 May 1;83(6):975-83. doi: 10.1002/ccd.25179. Epub 2014 Jan 31. PMID- 9799185 OWN - NLM STAT- MEDLINE DCOM- 19990106 LR - 20181113 IS - 0091-6765 (Print) IS - 0091-6765 (Linking) VI - 106 IP - 11 DP - 1998 Nov TI - Cancer risk assessment of extremely low frequency electric and magnetic fields: a critical review of methodology. PG - 701-17 AB - This review provides a discussion of cancer risk assessment methodology pertinent to developing a strategy for extremely low frequency electric and magnetic fields (EMF). Approaches taken for chemical agents or ionizing radiation in six key topic areas are briefly reviewed, and then those areas are examined from the perspective of EMF, identifying issues to be addressed in developing a risk assessment strategy. The following recommendations are offered: 1) risk assessment should be viewed as an iterative process that informs an overall judgment as to health risk and consists of a complex of related activities incorporating both positive and negative data, tumor and nontumor end points, and human and nonhuman sources of information; 2) a hazard identification resulting in a conclusion of weak or null effects, such as may be associated with EMF, will need to assign significant weight to animal cancer bioassays conducted under defined exposure conditions as well as to human epidemiologic studies; 3) a default factor to account for possible age differences in sensitivity to carcinogenesis should be included in an EMF risk assessment; 4) lack of evidence of dose response and the apparent lack of DNA reactivity of EMF suggest that a safety (or uncertainty) factor or margin of exposure type of risk characterization may be most appropriate; and 5) an EMF risk assessment should permit at least tentative conclusions to be reached as to the limits of carcinogenic risk from exposure to EMF, and should also define an efficient research agenda aimed at clarifying uncertainties appropriate to a more complete assessment. FAU - McCann, J AU - McCann J AD - Electric Power Research Institute, Palo Alto, CA 94303 USA. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Environ Health Perspect JT - Environmental health perspectives JID - 0330411 SB - IM MH - Animals MH - Electromagnetic Fields/*adverse effects MH - Humans MH - Neoplasms/*etiology MH - Risk Assessment/methods/*standards PMC - PMC1533493 EDAT- 1998/11/03 00:00 MHDA- 1998/11/03 00:01 PMCR- 1998/11/01 CRDT- 1998/11/03 00:00 PHST- 1998/11/03 00:00 [pubmed] PHST- 1998/11/03 00:01 [medline] PHST- 1998/11/03 00:00 [entrez] PHST- 1998/11/01 00:00 [pmc-release] AID - 10.1289/ehp.106-1533493 [doi] PST - ppublish SO - Environ Health Perspect. 1998 Nov;106(11):701-17. doi: 10.1289/ehp.106-1533493. PMID- 8341808 OWN - NLM STAT- MEDLINE DCOM- 19930902 LR - 20191023 IS - 0272-4332 (Print) IS - 0272-4332 (Linking) VI - 13 IP - 3 DP - 1993 Jun TI - Should persons with diabetes be licensed to drive trucks?--Risk management. PG - 327-34 AB - How should a regulatory agency interpret a risk analysis that concludes there is a small increase in risk? The agency must decide on behalf of society whether the increased risk is large enough to justify banning the risky activity or taking some other step to lessen the risks. In a companion paper (Songer et al.), we conclude that licensing insulin using persons to drive commercial motor vehicles in interstate commerce would result in 42 additional crashes each year. Here we address risk management issues by interpreting the number of additional crashes and the relative risks of the prospective handicapped drivers. Are the number of additional crashes (42) significant? Is the increase in the annual crash risk (from 0.00785 to 0.032 for non-insulin dependent and 0.048 for insulin dependent persons) significant? Are the relative risks significant for all insulin using drivers (4.7)? For drivers with a history of severe hypoglycemic reactions (19.8)? How should society tradeoff risk increases for increases in opportunity for these handicapped persons? We review other social decisions concerning highway safety: Accepting the increasing risks of letting 16 year olds drive, allowing extremely light cars, allowing some unsafe highways, and allowing extremely unsafe driving conditions at some times of day. We conclude that the additional risks from insulin using persons are well within the current accepted range of risks.(ABSTRACT TRUNCATED AT 250 WORDS) FAU - Lave, L B AU - Lave LB AD - Graduate School of Industrial Administration, Carnegie Mellon University, Pittsburgh, Pennsylvania. FAU - Songer, T J AU - Songer TJ FAU - LaPorte, R E AU - LaPorte RE LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - Risk Anal JT - Risk analysis : an official publication of the Society for Risk Analysis JID - 8109978 SB - IM MH - Accidents, Traffic/economics MH - Adolescent MH - Adult MH - Automobile Driving/*legislation & jurisprudence MH - Costs and Cost Analysis MH - *Diabetes Mellitus MH - Female MH - Humans MH - Licensure/*legislation & jurisprudence MH - Male MH - Middle Aged MH - Risk Management MH - United States EDAT- 1993/06/01 00:00 MHDA- 1993/06/01 00:01 CRDT- 1993/06/01 00:00 PHST- 1993/06/01 00:00 [pubmed] PHST- 1993/06/01 00:01 [medline] PHST- 1993/06/01 00:00 [entrez] AID - 10.1111/j.1539-6924.1993.tb01084.x [doi] PST - ppublish SO - Risk Anal. 1993 Jun;13(3):327-34. doi: 10.1111/j.1539-6924.1993.tb01084.x. PMID- 24117694 OWN - NLM STAT- MEDLINE DCOM- 20160221 LR - 20150803 IS - 1468-2494 (Electronic) IS - 0142-5463 (Linking) VI - 36 IP - 1 DP - 2014 Feb TI - Determination of the influence of factors (ethanol, pH and a(w) ) on the preservation of cosmetics using experimental design. PG - 54-61 LID - 10.1111/ics.12094 [doi] AB - OBJECTIVE: Ethanol, pH and water activity are three well-known parameters that can influence the preservation of cosmetic products. With the new constraints regarding the antimicrobial effectiveness and the restrictive use of preservatives, a D-optimal design was set up to evaluate the influence of these three parameters on the microbiological conservation. METHODS: To monitor the effectiveness of the different combination of these set parameters, a challenge test in compliance with the International standard ISO 11930: 2012 was implemented. The formulations established in our study could support wide variations of ethanol concentration, pH values and glycerin concentration without noticeable effects on the stability of the products. RESULTS: In the conditions of the study, determining the value of a single parameter, with the tested concentration, could not guarantee microbiological conservation. However, a high concentration of ethanol associated with an extreme pH could inhibit bacteria growth from the first day (D0). Besides, it appears that despite an aw above 0.6 (even 0.8) and without any preservatives incorporated in formulas, it was possible to guarantee the microbiological stability of the cosmetic product when maintaining the right combination of the selected parameters. CONCLUSION: Following the analysis of the different values obtained during the experimentation, there seems to be a correlation between the aw and the selected parameters aforementioned. An application of this relationship could be to define the aw of cosmetic products by using the formula, thus avoiding the evaluation of this parameter with a measuring device. CI - © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie. FAU - Berthele, H AU - Berthele H AD - EXPERTOX Agency and Laboratory, 14 rue Godefroy Cavaignac, 75011, Paris, France. AD - Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, France. FAU - Sella, O AU - Sella O AD - Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, France. FAU - Lavarde, M AU - Lavarde M AD - Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, France. FAU - Mielcarek, C AU - Mielcarek C AD - Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, France. FAU - Pense-Lheritier, A-M AU - Pense-Lheritier AM AD - Ecole de Biologie Industrielle (EBI), 32 Bd du port, 95094, Cergy, France. FAU - Pirnay, S AU - Pirnay S AD - EXPERTOX Agency and Laboratory, 14 rue Godefroy Cavaignac, 75011, Paris, France. LA - eng PT - Journal Article DEP - 20131108 PL - England TA - Int J Cosmet Sci JT - International journal of cosmetic science JID - 8007161 RN - 0 (Cosmetics) RN - 0 (Preservatives, Pharmaceutical) RN - 3K9958V90M (Ethanol) SB - IM MH - Animals MH - Candida albicans/isolation & purification MH - *Cosmetics MH - Escherichia coli/isolation & purification MH - Ethanol/*chemistry MH - *Hydrogen-Ion Concentration MH - *Preservatives, Pharmaceutical MH - Pseudomonas aeruginosa/isolation & purification MH - Staphylococcus aureus/isolation & purification OTO - NOTNLM OT - aw OT - challenge test OT - experimental design OT - formulation/stability OT - microbiology OT - safety testing EDAT- 2013/10/15 06:00 MHDA- 2016/02/22 06:00 CRDT- 2013/10/15 06:00 PHST- 2013/04/12 00:00 [received] PHST- 2013/09/15 00:00 [accepted] PHST- 2013/10/15 06:00 [entrez] PHST- 2013/10/15 06:00 [pubmed] PHST- 2016/02/22 06:00 [medline] AID - 10.1111/ics.12094 [doi] PST - ppublish SO - Int J Cosmet Sci. 2014 Feb;36(1):54-61. doi: 10.1111/ics.12094. Epub 2013 Nov 8. PMID- 32863755 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240801 IS - 1394-195X (Print) IS - 2180-4303 (Electronic) IS - 1394-195X (Linking) VI - 27 IP - 4 DP - 2020 Jul TI - Ivermectin: Potential Role as Repurposed Drug for COVID-19. PG - 154-158 LID - 10.21315/mjms2020.27.4.15 [doi] AB - Severe acute respiratory illness caused by 2019 novel coronavirus (2019-nCoV), officially named severe acute respiratory syndrome coronavirus (SARS-CoV-2) in late December 2019 is an extremely communicable disease. World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) as a pandemic as it has spread to at least 200 countries in a short span of time. Being a new disease there is lack of information about pathogenesis and proliferation pathways of this new coronavirus. Currently there is no effective treatment for coronavirus infection; major effort is to develop vaccine against the virus and development of therapeutic drugs for the disease. The development of genome-based vaccine and therapeutic antibodies require thorough testing for safety and will be available after some time. In the meanwhile, the available practical approach is to repurpose existing therapeutic agents, with proven safety record as a rapid response measure for the current pandemic. Here we discuss the presently used repurposed drugs for COVID-19 and the potential for ivermectin (IVM) to be used as a therapeutic option in COVID-19. CI - © Penerbit Universiti Sains Malaysia, 2020. FAU - Dixit, Alok AU - Dixit A AD - Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India. FAU - Yadav, Ramakant AU - Yadav R AD - Department of Neurology, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India. FAU - Singh, Amit Vikram AU - Singh AV AD - Department of Pharmacology, Uttar Pradesh University of Medical Sciences, Uttar Pradesh, India. LA - eng PT - Journal Article DEP - 20200819 PL - Malaysia TA - Malays J Med Sci JT - The Malaysian journal of medical sciences : MJMS JID - 101126308 CIN - Malays J Med Sci. 2021 Apr;28(2):177. doi: 10.21315/mjms2021.28.2.17. PMID: 33958972 PMC - PMC7444833 OTO - NOTNLM OT - SARS-CoV-2 OT - antiparasitic OT - coronavirus disease 2019 OT - drug repurposing OT - ivermectin COIS- Conflicts of Interest None. EDAT- 2020/08/31 06:00 MHDA- 2020/08/31 06:01 PMCR- 2020/07/01 CRDT- 2020/09/01 06:00 PHST- 2020/05/13 00:00 [received] PHST- 2020/06/21 00:00 [accepted] PHST- 2020/09/01 06:00 [entrez] PHST- 2020/08/31 06:00 [pubmed] PHST- 2020/08/31 06:01 [medline] PHST- 2020/07/01 00:00 [pmc-release] AID - 15mjms27042020_bc [pii] AID - 10.21315/mjms2020.27.4.15 [doi] PST - ppublish SO - Malays J Med Sci. 2020 Jul;27(4):154-158. doi: 10.21315/mjms2020.27.4.15. Epub 2020 Aug 19. PMID- 17495668 OWN - NLM STAT- MEDLINE DCOM- 20070705 LR - 20071115 IS - 0017-9078 (Print) IS - 0017-9078 (Linking) VI - 92 IP - 6 DP - 2007 Jun TI - Accounting for human variability and sensitivity in setting standards for electromagnetic fields. PG - 649-57 AB - Biological sensitivity and variability are key issues for risk assessment and standard setting. Variability encompasses general inter-individual variations in population responses, while sensitivity relates to unusual or extreme responses based on genetic, congenital, medical, or environmental conditions. For risk assessment and standard setting, these factors affect estimates of thresholds for effects and dose-response relationships and inform efforts to protect the more sensitive members of the population, not just the typical or average person. While issues of variability and sensitivity can be addressed by experimental and clinical studies of electromagnetic fields, investigators have paid little attention to these important issues. This paper provides examples that illustrate how default assumptions regarding variability can be incorporated into estimates of 60-Hz magnetic field exposures with no risk of cardiac stimulation and how population thresholds and variability of peripheral nerve stimulation responses at 60-Hz can be estimated from studies of pulsed gradient magnetic fields in magnetic resonance imaging studies. In the setting of standards for radiofrequency exposures, the International Commission for Non-Ionizing Radiation Protection uses inter-individual differences in thermal sensitivity as one of the considerations in the development of "safety factors." However, neither the range of sensitivity nor the sufficiency or excess of the 10-fold and the additional 5-fold safety factors have been assessed quantitatively. Data on the range of responses between median and sensitive individuals regarding heat stress and cognitive function should be evaluated to inform a reassessment of these safety factors and to identify data gaps. FAU - Bailey, William H AU - Bailey WH AD - Exponent Health Sciences Practice, New York, NY 10170, USA. wbailey@exponent.com FAU - Erdreich, Linda S AU - Erdreich LS LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Health Phys JT - Health physics JID - 2985093R SB - IM MH - Body Burden MH - *Electromagnetic Fields MH - Environmental Exposure/*analysis/standards MH - Humans MH - *Models, Biological MH - *Practice Guidelines as Topic MH - Quality Assurance, Health Care/methods/standards MH - Radiation Dosage MH - Radiation Monitoring/methods/*standards MH - Radiation Protection/methods/*standards MH - Relative Biological Effectiveness MH - Reproducibility of Results MH - Sensitivity and Specificity MH - Whole-Body Counting/methods/*standards RF - 45 EDAT- 2007/05/15 09:00 MHDA- 2007/07/06 09:00 CRDT- 2007/05/15 09:00 PHST- 2007/05/15 09:00 [pubmed] PHST- 2007/07/06 09:00 [medline] PHST- 2007/05/15 09:00 [entrez] AID - 00004032-200706000-00020 [pii] AID - 10.1097/01.HP.0000249741.31108.ce [doi] PST - ppublish SO - Health Phys. 2007 Jun;92(6):649-57. doi: 10.1097/01.HP.0000249741.31108.ce. PMID- 37492782 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230727 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 9 IP - 3 DP - 2023 TI - Protective guidelines and mitigation strategies for hot conditions in professional football: starting 11 Hot Tips for consideration. PG - e001608 LID - 10.1136/bmjsem-2023-001608 [doi] LID - e001608 AB - Elevated heat, humidity and solar load combined with low air movement independently and additively impair performance, increase the perception of effort and the risk of heat-related illnesses. For the specific context of professional football, the Fédération Internationale de Football Association (FIFA) heat guidelines are often used as the default policy. Still, these seem less protective than guidelines in other sports or from countries traditionally exposed to extreme hot conditions. Following several high-profile international and continental competitions played in hot conditions (eg, 2014 FIFA World Cup Brazil), a series of cross-sectional studies showed that national team players and their managers unanimously mentioned that the hot and humid conditions during these matches made it difficult as a team to perform. Such a concern is likely to be relevant for the upcoming 2026 FIFA World Cup that will be held in the traditional June-July window across 16 host cities in Canada, Mexico and USA. Therefore, to better protect players' health and performance during training and match play in hot conditions, we present our starting 11 Hot Tips that should be considered and facilitated by governing bodies, competition organisers, clubs, staff members and players. CI - © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Gouttebarge, Vincent AU - Gouttebarge V AUID- ORCID: 0000-0002-0126-4177 AD - Football Players Worldwide (FIFPRO), Hoofddorp, Netherlands. AD - Amsterdam UMC location University of Amsterdam, Department of Orthopedic Surgery and Sports Medicine, Meibergdreef 9, Amsterdam, Netherlands. AD - Amsterdam Collaboration on Health & Safety in Sports (ACHSS), IOC Research Center, Amsterdam, Netherlands. AD - Section Sports Medicine, University of Pretoria, Pretoria, South Africa. FAU - Duffield, Rob AU - Duffield R AD - School of Sport, Exercise and Rehabilitation, Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia. FAU - den Hollander, Steve AU - den Hollander S AUID- ORCID: 0000-0002-6064-038X AD - Football Players Worldwide (FIFPRO), Hoofddorp, Netherlands. FAU - Maughan, Ron AU - Maughan R AD - School of Medicine, St Andrews University, St Andrews, UK. LA - eng PT - Journal Article DEP - 20230721 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC10364156 OTO - NOTNLM OT - Football OT - Heat stress OT - Thermoregulation COIS- Competing interests: None declared. EDAT- 2023/07/26 06:43 MHDA- 2023/07/26 06:44 PMCR- 2023/07/21 CRDT- 2023/07/26 03:57 PHST- 2023/07/26 06:44 [medline] PHST- 2023/07/26 06:43 [pubmed] PHST- 2023/07/26 03:57 [entrez] PHST- 2023/07/21 00:00 [pmc-release] AID - bmjsem-2023-001608 [pii] AID - 10.1136/bmjsem-2023-001608 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2023 Jul 21;9(3):e001608. doi: 10.1136/bmjsem-2023-001608. eCollection 2023. PMID- 37941686 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231110 IS - 2433-3298 (Electronic) IS - 2433-328X (Print) IS - 2433-328X (Linking) VI - 6 IP - 4 DP - 2023 Oct 16 TI - Short-term All-cause In-hospital Mortality Prediction by Machine Learning Using Numeric Laboratory Results. PG - 470-480 LID - 10.31662/jmaj.2022-0206 [doi] AB - INTRODUCTION: A critical value (or panic value) is a laboratory test result that significantly deviates from the normal value and represents a potentially life-threatening condition requiring immediate action. Although notification of critical values by critical value list (CVL) is a well-established method, their contribution to mortality prediction is unclear. METHODS: A total of 335,430 clinical laboratory results from 92,673 patients from July 2018 to December 2019 were used. Data in the first 12 months were divided into two datasets at a ratio of 70:30, and a 7-day mortality prediction model by machine learning (eXtreme Gradient Boosting [XGB] decision tree) was created using stratified random undersampling data of the 70% dataset. Mortality predictions by the CVL and XGB model were validated using the remaining 30% of the data, as well as different 6-month datasets from July to December 2019. RESULTS: The true results which were the sum of correct predictions by the XGB model and CVL using the remaining 30% data were 61,535 and 61,024 tests, and the false results which were the sum of incorrect predictions were 5,492 and 6,003, respectively. Furthermore, the true results with the different datasets were 105,956 and 102,061 tests, and the false results were 6,052 and 9,947, respectively. The XGB model was significantly better than CVL (p < 0.001) in both datasets.The receiver operating characteristic-area under the curve values for the 30% and validation data by XGB were 0.9807 and 0.9646, respectively, which were significantly higher than those by CVL (0.7549 and 0.7172, respectively). CONCLUSIONS: Mortality prediction within 7 days by machine learning using numeric laboratory results was significantly better than that by conventional CVL. The results indicate that machine learning enables timely notification to healthcare providers and may be safer than prediction by conventional CVL. CI - Copyright © Japan Medical Association. FAU - Shimada, Gen AU - Shimada G AD - Hernia Center, St. Luke's International Hospital, Tokyo, Japan. AD - Department of Gastroenterological and General Surgery, St. Luke's International Hospital, Tokyo, Japan. FAU - Nakabayashi, Rumi AU - Nakabayashi R AD - Department of Gastroenterological and General Surgery, St. Luke's International Hospital, Tokyo, Japan. FAU - Komatsu, Yasuhiro AU - Komatsu Y AD - Department of Nephrology, St. Luke's International Hospital, Tokyo, Japan. AD - Department of Healthcare Quality and Safety, Graduate School of Medicine, Gunma University, Gunma, Japan. LA - eng PT - Journal Article DEP - 20230929 PL - Japan TA - JMA J JT - JMA journal JID - 101769797 PMC - PMC10628331 OTO - NOTNLM OT - Critical value list OT - laboratory test OT - machine learning OT - mortality prediction COIS- None EDAT- 2023/11/09 06:42 MHDA- 2023/11/09 06:43 PMCR- 2023/09/29 CRDT- 2023/11/09 04:10 PHST- 2022/12/18 00:00 [received] PHST- 2023/08/08 00:00 [accepted] PHST- 2023/11/09 06:43 [medline] PHST- 2023/11/09 06:42 [pubmed] PHST- 2023/11/09 04:10 [entrez] PHST- 2023/09/29 00:00 [pmc-release] AID - 10.31662/jmaj.2022-0206 [doi] PST - ppublish SO - JMA J. 2023 Oct 16;6(4):470-480. doi: 10.31662/jmaj.2022-0206. Epub 2023 Sep 29. PMID- 31852754 OWN - NLM STAT- MEDLINE DCOM- 20200908 LR - 20200908 IS - 1477-9145 (Electronic) IS - 0022-0949 (Linking) VI - 223 IP - Pt 2 DP - 2020 Jan 27 TI - Mind the gap: natural cleft palates reduce biting performance in bats. LID - jeb196535 [pii] LID - 10.1242/jeb.196535 [doi] AB - Novel morphological traits pose interesting evolutionary paradoxes when they become widespread in a lineage while being deleterious in others. Cleft palate is a rare congenital condition in mammals in which the incisor-bearing premaxilla bones of the upper jaw develop abnormally. However, ∼50% of bat species have natural, non-pathological cleft palates. We used the family Vespertilionidae as a model and linear and geometric morphometrics within a phylogenetic framework to (1) explore evolutionary patterns in cleft morphology, and (2) test whether cleft morphological variation is correlated with skull shape in bats. We also used finite element (FE) analyses to experimentally test how presence of a cleft palate impacts skull performance during biting in a species with extreme cleft morphology (hoary bat, Lasiurus cinereus). We constructed and compared the performance of two FE models: one based on the hoary bat's natural skull morphology, and another with a digitally filled cleft simulating a complete premaxilla. Results showed that cleft length and width are correlated with skull shape in Vespertilionidae, with narrower, shallower clefts seen in more gracile skulls and broader, deeper clefts in more robust skulls. FE analysis showed that the model with a natural cleft produced lower bite forces, and had higher stress and strain than the model with a filled cleft. In the rostrum, safety factors were 1.59-2.20 times higher in the model with a filled cleft than in the natural model. Our results demonstrate that cleft palates in bats reduce biting performance, and evolution of skull robusticity may compensate for this reduction in performance. CI - © 2020. Published by The Company of Biologists Ltd. FAU - Curtis, Abigail A AU - Curtis AA AUID- ORCID: 0000-0002-9774-2814 AD - Department of Biology, University of Washington, Seattle, WA 98195-1800, USA abigailacurtis@gmail.com. FAU - Arbour, Jessica H AU - Arbour JH AD - Department of Biology, University of Washington, Seattle, WA 98195-1800, USA. FAU - Santana, Sharlene E AU - Santana SE AD - Department of Biology, University of Washington, Seattle, WA 98195-1800, USA. AD - Burke Museum of Natural History and Culture, University of Washington, Seattle, WA 98195-1800, USA. LA - eng SI - Dryad/10.5061/dryad.kwh70rz0k PT - Journal Article DEP - 20200127 PL - England TA - J Exp Biol JT - The Journal of experimental biology JID - 0243705 SB - IM MH - Animals MH - Chiroptera/*anatomy & histology/*physiology MH - *Feeding Behavior MH - Models, Biological MH - Palate/*anatomy & histology MH - Skull/*anatomy & histology MH - Species Specificity OTO - NOTNLM OT - Bats OT - Biting OT - Cranial morphology OT - Finite element analysis OT - Geometric morphometrics OT - Vespertilionidae COIS- Competing interestsThe authors declare no competing or financial interests. EDAT- 2019/12/20 06:00 MHDA- 2020/09/09 06:00 CRDT- 2019/12/20 06:00 PHST- 2018/11/16 00:00 [received] PHST- 2019/12/12 00:00 [accepted] PHST- 2019/12/20 06:00 [pubmed] PHST- 2020/09/09 06:00 [medline] PHST- 2019/12/20 06:00 [entrez] AID - jeb.196535 [pii] AID - 10.1242/jeb.196535 [doi] PST - epublish SO - J Exp Biol. 2020 Jan 27;223(Pt 2):jeb196535. doi: 10.1242/jeb.196535. PMID- 16177684 OWN - NLM STAT- MEDLINE DCOM- 20050926 LR - 20080214 IS - 1545-861X (Electronic) IS - 0149-2195 (Linking) VI - 54 IP - 37 DP - 2005 Sep 23 TI - Perceptions of neighborhood characteristics and leisure-time physical inactivity--Austin/Travis County, Texas, 2004. PG - 926-8 AB - Regular physical activity improves quality of life and reduces risk for coronary heart disease, colon cancer, hypertension, diabetes, and overall mortality. Physical activity also has been associated with reduced symptoms of depression and greater independence. A sedentary lifestyle is associated with obesity. However, despite the health benefits of physical activity, 23.1% of adults in the United States report they do not engage in any leisure-time physical activity. Neighborhood environment (e.g., sidewalks and street lighting), perceived trustworthiness of neighbors, and perceptions of neighborhood safety all have been associated with levels of physical activity. During 2004, to assess the association between these factors and leisure-time physical inactivity in eastern Travis County, Texas, the local health department collected and analyzed data by using the methodology of the Behavioral Risk Factor Surveillance System (BRFSS). This report describes the results of that analysis, which indicated that persons who perceived their neighborhoods as less than extremely safe were more than twice as likely to have no leisure-time physical activity, and those who perceived their neighborhoods as not at all safe were nearly three times as likely to have no leisure-time physical activity. Public health agencies promoting physical activity in neighborhoods should consider how residents perceive their safety and design programs that specifically address those safety concerns. CN - Centers for Disease Control and Prevention (CDC) LA - eng PT - Journal Article PL - United States TA - MMWR Morb Mortal Wkly Rep JT - MMWR. Morbidity and mortality weekly report JID - 7802429 SB - IM MH - Adult MH - Behavioral Risk Factor Surveillance System MH - Female MH - Humans MH - *Leisure Activities MH - Male MH - Middle Aged MH - *Physical Fitness MH - *Residence Characteristics MH - Texas EDAT- 2005/09/24 09:00 MHDA- 2005/09/27 09:00 CRDT- 2005/09/24 09:00 PHST- 2005/09/24 09:00 [pubmed] PHST- 2005/09/27 09:00 [medline] PHST- 2005/09/24 09:00 [entrez] AID - mm5437a4 [pii] PST - ppublish SO - MMWR Morb Mortal Wkly Rep. 2005 Sep 23;54(37):926-8. PMID- 36339225 OWN - NLM STAT- MEDLINE DCOM- 20221108 LR - 20230918 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 10 DP - 2022 TI - Urban heat vulnerability: A dynamic assessment using multi-source data in coastal metropolis of Southeast China. PG - 989963 LID - 10.3389/fpubh.2022.989963 [doi] LID - 989963 AB - Extreme heat caused by global climate change has become a serious threat to the sustainable development of urban areas. Scientific assessment of the impacts of extreme heat on urban areas and in-depth knowledge of the cross-scale mechanisms of heat vulnerability forming in urban systems are expected to support policymakers and stakeholders in developing effective policies to mitigate the economic, social, and health risks. Based on the perspective of the human-environment system, this study constructed a conceptual framework and index system of "exposure-susceptibility-adaptive capacity" for urban heat vulnerability (UHV) and proposed its assessment methods. Taking Xiamen City, a coastal metropolis, as an example, spatial analysis and Geodetector were used to explore the spatial and temporal changes, spatial characteristics, and patterns of UHV under multiple external disturbances from natural to anthropological factors, and to reveal the main factors influencing UHV forming and spatial differentiation. Results showed that the exposure, susceptibility, adaptive capacity, and UHV in Xiamen City had a spatial structure of "coastal-offshore-inland". On the hot day, both the exposure and UHV showed a temporal pattern of "rising and then falling, peaking at 14:00" and a spatial pattern of "monsoonal-like" movement between coast and inland. Coastal zoning with favorable socioeconomic conditions had less magnitude of changes in UHV, where the stability of the urban system was more likely to be maintained. During the hot months, the high UHV areas were mainly distributed in the inland, while coastal areas showed low UHV levels. Further, coastal UHV was mainly dominated by "heat exposure", offshore by "comprehensive factors", and inland in the northern mountainous areas by "lack of adaptive capacity". Multi-scale urban adaptive capacity was confirmed to alter spatial distribution of exposure and reshape the spatial pattern of UHV. This study promotes the application of multi-scale vulnerability framework to disaster impact assessment, enriches the scientific knowledge of the urban system vulnerability, and provides scientific references for local targeted cooling policy development and extreme heat resilience building programs. CI - Copyright © 2022 Wu, Shui, Huang, Wang, Wu, Wu, Xue, Huang, Zhang and Zheng. FAU - Wu, Chaowei AU - Wu C AD - College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. AD - School of Public Health, Fudan University, Shanghai, China. FAU - Shui, Wei AU - Shui W AD - College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Huang, Zhigang AU - Huang Z AD - Fujian Meteorological Bureau, Fuzhou, China. AD - Fujian Meteorological Service Center, Fujian Meteorological Bureau, Fuzhou, China. FAU - Wang, Chunhui AU - Wang C AD - Fujian Meteorological Service Center, Fujian Meteorological Bureau, Fuzhou, China. FAU - Wu, Yuehui AU - Wu Y AD - Taining Meteorological Bureau, Taining, China. FAU - Wu, Yinpan AU - Wu Y AD - College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Xue, Chengzhi AU - Xue C AD - College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Huang, Yunhui AU - Huang Y AD - College of Environment and Safety Engineering, Fuzhou University, Fuzhou, China. FAU - Zhang, Yiyi AU - Zhang Y AD - Department of Geography, McGill University, Montreal, QC, Canada. FAU - Zheng, Dongyang AU - Zheng D AD - Fujian Zhitianqi Information Technology Co., Ltd, Fuzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20221020 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Hot Temperature MH - *Climate Change MH - Cities MH - China PMC - PMC9632749 OTO - NOTNLM OT - Xiamen City OT - climate change OT - dynamic assessment OT - extreme heat OT - human-environment system OT - vulnerability COIS- Author DZ is a key member of this study and currently works for Fujian Zhitianqi Information Technology Co., Ltd. This study has no commercial or financial relationship with this company and received no funding from Fujian Zhitianqi Information Technology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/11/08 06:00 MHDA- 2022/11/09 06:00 PMCR- 2022/10/20 CRDT- 2022/11/07 04:41 PHST- 2022/07/09 00:00 [received] PHST- 2022/09/08 00:00 [accepted] PHST- 2022/11/07 04:41 [entrez] PHST- 2022/11/08 06:00 [pubmed] PHST- 2022/11/09 06:00 [medline] PHST- 2022/10/20 00:00 [pmc-release] AID - 10.3389/fpubh.2022.989963 [doi] PST - epublish SO - Front Public Health. 2022 Oct 20;10:989963. doi: 10.3389/fpubh.2022.989963. eCollection 2022. PMID- 25970868 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 2159-3000 (Print) IS - 2159-3000 (Linking) VI - 432 DP - 2015 May TI - Chronic pain management: evaluation of chronic pain. PG - 11-20 AB - Chronic pain (CP) is a heterogeneous group of conditions classified as neuropathic, muscular, visceral, inflammatory, or mixed. The pathogenesis is not completely understood, but neuroanatomic changes and central sensitization, in which the central nervous system amplifies pain transmission, are associated maladaptations. When treating a patient with CP, first classify the type of pain, if possible; assess its intensity; and assess its influence on health, well-being, and comorbidities. Then develop a treatment plan. At each visit, clinicians should assess analgesia (pain level/relief), affect (mood assessment), and activities of daily living (functional status); obtain a pill count, if appropriate; optimize adjuvant therapy; and evaluate for adverse effects and aberrant drug-related behavior. Accurate documentation of behavioral indicators of pain, responses to interventions, and management strategies is extremely important in facilitating continuity of care and patient safety. CI - Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium. FAU - Chang, Ku-Lang AU - Chang KL AD - University of Florida Health Family Medicine - Hampton Oaks, 200 SW 62nd Blvd Suite D, Gainesville, FL 32608, changk@shands.ufl.edu. FAU - Fillingim, Roger AU - Fillingim R AD - Clinical and Translational Research Building Room 3216, 2004 Mowry Road, Gainesville, FL 32610-0404, RFillingim@dental.ufl.edu. FAU - Hurley, Robert W AU - Hurley RW AD - MCW Pain Management Center, 959 N. North Mayfair Road, Milwaukee, WI 53226, rwhurley2010@gmail.com. FAU - Schmidt, Siegfried AU - Schmidt S AD - University of Florida Health Family Medicine - Hampton Oaks, 200 SW 62nd Blvd Suite D, Gainesville, FL 32608, siggy@shands.ufl.edu. LA - eng PT - Journal Article PL - United States TA - FP Essent JT - FP essentials JID - 101578821 SB - IM EDAT- 2015/05/15 06:00 MHDA- 2015/05/15 06:01 CRDT- 2015/05/14 06:00 PHST- 2015/05/14 06:00 [entrez] PHST- 2015/05/15 06:00 [pubmed] PHST- 2015/05/15 06:01 [medline] PST - ppublish SO - FP Essent. 2015 May;432:11-20. PMID- 12784776 OWN - NLM STAT- MEDLINE DCOM- 20040217 LR - 20151119 IS - 1129-471X (Print) IS - 1129-471X (Linking) VI - 4 IP - 4 DP - 2003 Apr TI - Through the drug-eluting stent labyrinth. PG - 236-45 AB - For interventional cardiologists restenosis has represented the main limit for the successful long-term treatment of coronary artery disease. The past 2 years witnessed the extraordinary results of drug-eluting stents (DES), putting this technique at the center stage. The safety and efficacy of sirolimus and paclitaxel-eluting stents have been proved in large prospective, multicenter, randomized trials (RAVEL, SIRIUS, TAXUS II). It is possible that the introduction of DES will lead to substantial changes in the therapeutic and/or the economic strategies of the treatment of ischemic coronary artery disease (increase in the complexity of patients treated, reduction in surgical indications, growing costs). Realizing the potential value of this technology will require the successful management of more complex coronary situations (for lesions and patients characteristics). Many extreme situations are still unexplored, although for some of them studies are currently in progress or already being planned. FAU - Guagliumi, Giulio AU - Guagliumi G AD - Cardiovascular Department, Ospedali Riuniti, Bergamo. guagliumig@interfree.it FAU - Musumeci, Giuseppe AU - Musumeci G FAU - Vassileva, Angelina AU - Vassileva A FAU - Tespili, Maurizio AU - Tespili M FAU - Valsecchi, Orazio AU - Valsecchi O LA - eng PT - Journal Article PT - Review PL - Italy TA - Ital Heart J JT - Italian heart journal : official journal of the Italian Federation of Cardiology JID - 100909716 RN - 0 (Antineoplastic Agents, Phytogenic) RN - 0 (Coated Materials, Biocompatible) RN - 0 (Immunosuppressive Agents) RN - P88XT4IS4D (Paclitaxel) RN - W36ZG6FT64 (Sirolimus) SB - IM MH - *Angioplasty, Balloon, Coronary MH - *Antineoplastic Agents, Phytogenic MH - *Coated Materials, Biocompatible MH - Coronary Disease/*therapy MH - Coronary Restenosis/*prevention & control MH - Costs and Cost Analysis MH - Humans MH - *Immunosuppressive Agents MH - *Paclitaxel MH - Randomized Controlled Trials as Topic MH - *Sirolimus MH - *Stents/adverse effects RF - 40 EDAT- 2003/06/06 05:00 MHDA- 2004/02/18 05:00 CRDT- 2003/06/06 05:00 PHST- 2003/06/06 05:00 [pubmed] PHST- 2004/02/18 05:00 [medline] PHST- 2003/06/06 05:00 [entrez] PST - ppublish SO - Ital Heart J. 2003 Apr;4(4):236-45. PMID- 17956200 OWN - NLM STAT- MEDLINE DCOM- 20071113 LR - 20220409 IS - 1744-7666 (Electronic) IS - 1465-6566 (Linking) VI - 8 IP - 16 DP - 2007 Nov TI - Apomorphine therapy in Parkinson's disease: a review. PG - 2799-809 AB - Motor fluctuations are common and distressing for patients with advanced Parkinson's disease. Subcutaneous apomorphine injections can be an extremely valuable adjunctive therapy. In this review, the authors discuss the history, pharmacology, efficacy, safety and proper administration of apomorphine for treating 'off' states in Parkinson's disease, with a focus on intermittent subcutaneous administration. FAU - Haq, Ihtsham Ul AU - Haq IU AD - Movement Disorders Program, University of Florida, Department of Neurology/McKnight Brain Institute, 100 S. Newell Drive, PO Box 100236, Gainesville, Florida 32610-0236, USA. ihtsham.haq@neurology.ufl.edu FAU - Lewitt, Peter A AU - Lewitt PA FAU - Fernandez, Hubert H AU - Fernandez HH LA - eng PT - Journal Article PT - Review PL - England TA - Expert Opin Pharmacother JT - Expert opinion on pharmacotherapy JID - 100897346 RN - 0 (Antiparkinson Agents) RN - 0 (Dopamine Agonists) RN - N21FAR7B4S (Apomorphine) SB - IM MH - Animals MH - Antiparkinson Agents/adverse effects/pharmacology/*therapeutic use MH - Apomorphine/adverse effects/pharmacology/*therapeutic use MH - Clinical Trials as Topic MH - Dopamine Agonists/adverse effects/pharmacology/*therapeutic use MH - Humans MH - Parkinson Disease/*drug therapy RF - 75 EDAT- 2007/10/25 09:00 MHDA- 2007/11/14 09:00 CRDT- 2007/10/25 09:00 PHST- 2007/10/25 09:00 [pubmed] PHST- 2007/11/14 09:00 [medline] PHST- 2007/10/25 09:00 [entrez] AID - 10.1517/14656566.8.16.2799 [doi] PST - ppublish SO - Expert Opin Pharmacother. 2007 Nov;8(16):2799-809. doi: 10.1517/14656566.8.16.2799. PMID- 30341710 OWN - NLM STAT- MEDLINE DCOM- 20190624 LR - 20190624 IS - 1559-0291 (Electronic) IS - 0273-2289 (Linking) VI - 188 IP - 1 DP - 2019 May TI - Enhanced Enzymatic Hydrolysis of Sorghum Stalk by Supercritical Carbon Dioxide and Ultrasonic Pretreatment. PG - 101-111 LID - 10.1007/s12010-018-2909-x [doi] AB - Sorghum was pretreated by sole ultrasound or supercritical carbon dioxide (scCO(2)), as well as the method combining both to intensify enzymatic hydrolysis. The effect of the time (1-5 h) and temperature (30-70 °C) on ultrasonic pretreatment was investigated, and the best condition was determined as 5 h and 50 °C with the EH sugar yield of 33.69%. The influence of the time (6-48 h), temperature (40-80 °C), and pressure (15-25 MPa) on scCO(2) pretreatment were also discussed in this study. The optimum condition of scCO2 pretreatment was identified as 60 °C, 20 MPa, and 36 h with the EH sugar yield of 43.57%. Compared with the sole ultrasonic or scCO(2) pretreatment, scCO(2) associated with the subsequent ultrasonic pretreatment did not show significant improvement in sugar yield. However, 30 MPa was an extremely effective pressure, which led to 45.50% EH sugar yield with 60 °C, 6-h pretreatment. Finally, the change of the microscopic structures of the sorghum stalk after the pretreatment was investigated using scanning electron microscope (SEM) and X-ray diffraction (XRD). FAU - Zhang, Qiaozhi AU - Zhang Q AD - State Key Laboratory of Fine Chemicals, School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116024, China. FAU - Zhao, Mengjiao AU - Zhao M AD - State Key Laboratory of Fine Chemicals, School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116024, China. FAU - Xu, Qinqin AU - Xu Q AD - State Key Laboratory of Fine Chemicals, School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116024, China. FAU - Ren, Hongrui AU - Ren H AD - State Key Laboratory of Fine Chemicals, School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116024, China. FAU - Yin, Jianzhong AU - Yin J AD - State Key Laboratory of Fine Chemicals, School of Chemical Machinery and Safety, Dalian University of Technology, Dalian, 116024, China. jzyin@dlut.edu.cn. LA - eng GR - U1662130/Petrochemicals Joint Fund between National Natural Science Foundation of China and China National Petroleum Corporation/ GR - 21506027/National Natural Science Foundation of China/ GR - DUT17JC34/Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20181020 PL - United States TA - Appl Biochem Biotechnol JT - Applied biochemistry and biotechnology JID - 8208561 RN - 142M471B3J (Carbon Dioxide) RN - EC 3.2.1.4 (Cellulase) SB - IM MH - Carbon Dioxide/*chemistry MH - Cellulase/*metabolism MH - Hot Temperature MH - Hydrolysis MH - Microscopy, Electron, Scanning MH - Pressure MH - Sorghum/*metabolism MH - *Ultrasonic Waves MH - X-Ray Diffraction OTO - NOTNLM OT - Enzymatic hydrolysis OT - Lignocellulose OT - Pretreatment OT - Supercritical CO2 OT - Ultrasound EDAT- 2018/10/21 06:00 MHDA- 2019/06/25 06:00 CRDT- 2018/10/21 06:00 PHST- 2018/07/30 00:00 [received] PHST- 2018/10/10 00:00 [accepted] PHST- 2018/10/21 06:00 [pubmed] PHST- 2019/06/25 06:00 [medline] PHST- 2018/10/21 06:00 [entrez] AID - 10.1007/s12010-018-2909-x [pii] AID - 10.1007/s12010-018-2909-x [doi] PST - ppublish SO - Appl Biochem Biotechnol. 2019 May;188(1):101-111. doi: 10.1007/s12010-018-2909-x. Epub 2018 Oct 20. PMID- 37926320 OWN - NLM STAT- MEDLINE DCOM- 20231228 LR - 20240106 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 254 IP - Pt 2 DP - 2024 Jan TI - ROS scavenging enzyme-encoding genes play important roles in the desert moss Syntrichia caninervis response to extreme cold and desiccation stresses. PG - 127778 LID - S0141-8130(23)04677-9 [pii] LID - 10.1016/j.ijbiomac.2023.127778 [doi] AB - Abiotic stress is one of the major environmental constraints limiting plant growth. Syntrichia caninervis is one of the unique plant models that can cope with harsh environments. Reactive oxygen species (ROS) are a vital signaling molecule for protecting plants from oxidative stress, but research on ROS in S. caninervis is limited. Here, we identified 112 ROS genes in S. caninervis, including 40 GSTs, 51 PODs, 9 SODs, 6 CATs, 3 GPXs and 3 APXs families. GO and KEGG analyses showed that ROS genes are involved in responses to various stimuli and phenylpropanoid biosynthesis. ROS genes contain many stress-responsive and hormonal cis-elements in their promoter regions. More ROS genes were induced by cold stress than desiccation stress, and both conditions changed the transcript abundances of several ROS genes. CAT and POD, H(2)O(2), MDA, and GSH were also induced under biotic stress, specifically CAT activity. The results indicated that the ScCAT genes and their activities could be strongly associated with the regulation of ROS production. This is the first systematic identification of ROS genes in S. caninervis and our findings contribute to further research into the roles of ScROS adjustment under abiotic stress while also providing excellent genetic resources for plant breeding. CI - Copyright © 2023 Elsevier B.V. All rights reserved. FAU - Salih, Haron AU - Salih H AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; Xinjiang Key Laboratory of Conservation and Utilization of Plant Gene Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 830000 Urumqi, China. FAU - Bai, Wenwan AU - Bai W AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Liang, Yuqing AU - Liang Y AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; Xinjiang Key Laboratory of Conservation and Utilization of Plant Gene Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 830000 Urumqi, China. FAU - Yang, RuiRui AU - Yang R AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Zhao, Mingqi AU - Zhao M AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; University of Chinese Academy of Sciences, Beijing 100049, China. FAU - Muhammd, Surayya Mustapha AU - Muhammd SM AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; Xinjiang Key Laboratory of Conservation and Utilization of Plant Gene Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 830000 Urumqi, China. FAU - Zhang, Daoyuan AU - Zhang D AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; Xinjiang Key Laboratory of Conservation and Utilization of Plant Gene Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 830000 Urumqi, China. FAU - Li, Xiaoshuang AU - Li X AD - State Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, China; Xinjiang Key Laboratory of Conservation and Utilization of Plant Gene Resources, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, 830000 Urumqi, China. Electronic address: lixs@ms.xjb.ac.cn. LA - eng PT - Journal Article DEP - 20231104 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 0 (Reactive Oxygen Species) RN - BBX060AN9V (Hydrogen Peroxide) SB - IM MH - Humans MH - Reactive Oxygen Species MH - Desiccation MH - *Extreme Cold MH - Hydrogen Peroxide MH - Plant Breeding MH - *Bryophyta MH - *Bryopsida MH - Stress, Physiological/genetics MH - Gene Expression Regulation, Plant OTO - NOTNLM OT - Antioxidant enzymes OT - Cold stress OT - Desiccation stress OT - ROS-scavenging enzyme-encoding genes OT - Syntrichia caninervis COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2023/11/06 00:41 MHDA- 2023/12/28 06:42 CRDT- 2023/11/05 19:16 PHST- 2023/07/19 00:00 [received] PHST- 2023/09/14 00:00 [revised] PHST- 2023/10/27 00:00 [accepted] PHST- 2023/12/28 06:42 [medline] PHST- 2023/11/06 00:41 [pubmed] PHST- 2023/11/05 19:16 [entrez] AID - S0141-8130(23)04677-9 [pii] AID - 10.1016/j.ijbiomac.2023.127778 [doi] PST - ppublish SO - Int J Biol Macromol. 2024 Jan;254(Pt 2):127778. doi: 10.1016/j.ijbiomac.2023.127778. Epub 2023 Nov 4. PMID- 10586552 OWN - NLM STAT- MEDLINE DCOM- 20000111 LR - 20181130 IS - 0021-4892 (Print) IS - 0021-4892 (Linking) VI - 48 IP - 11 DP - 1999 Nov TI - [Inorganic fluoride concentrations and their sequential changes in the five layers of the kidney in rabbits after sevoflurane or methoxyflurane anesthesia]. PG - 1202-10 AB - In this study, intrarenal inorganic fluoride concentrations (IR-F) in rabbits were measured after sevoflurane or methoxyflurane anesthesia (SA or MA) to investigate the mechanism of methoxy-flurane nephrotoxicity and to confirm the safety of SA in fluoride nephrotoxicity. At the end of SA of MA, IR-F was 1.5 to 5 times greater in the cortex to papilla region than serum fluoride concentrations (S-F). When S-F were nearly equal, IR-F after MA was not greater than IR-F after SA. IR-F after SA declined rapidly. In contrast, IR-F after MA was maintained at high levels for a protracted period due to the greater solubility of methoxyflurane in fatty tissue. The present study suggests that the most important factor in methoxyflurane nephrotoxicity is the high IR-F of long duration established by urine formation, and that sevoflurane, although it is not associated with fluoride nephrotoxicity under normal conditions, may not be safe when it is used for an extremely long period and at high concentrations. FAU - Kusume, Y AU - Kusume Y AD - Department of Anesthesiology and Resuscitology, Okayama University Medical School. LA - jpn PT - Journal Article PL - Japan TA - Masui JT - Masui. The Japanese journal of anesthesiology JID - 0413707 RN - 0 (Anesthetics, Inhalation) RN - 0 (Methyl Ethers) RN - 30905R8O7B (Methoxyflurane) RN - 38LVP0K73A (Sevoflurane) RN - Q80VPU408O (Fluorides) SB - IM MH - *Anesthesia, Inhalation MH - *Anesthetics, Inhalation/pharmacokinetics MH - Animals MH - Fluorides/*analysis/metabolism MH - Kidney/*metabolism/pathology MH - Male MH - *Methoxyflurane/pharmacokinetics MH - *Methyl Ethers/pharmacokinetics MH - Rabbits MH - Sevoflurane EDAT- 1999/12/10 00:00 MHDA- 1999/12/10 00:01 CRDT- 1999/12/10 00:00 PHST- 1999/12/10 00:00 [pubmed] PHST- 1999/12/10 00:01 [medline] PHST- 1999/12/10 00:00 [entrez] PST - ppublish SO - Masui. 1999 Nov;48(11):1202-10. PMID- 10103695 OWN - NLM STAT- MEDLINE DCOM- 19900320 LR - 20181130 IS - 0018-5787 (Print) IS - 0018-5787 (Linking) VI - 25 IP - 1 DP - 1990 Jan TI - Detection and prevention of ambulatory care pharmacy dispensing errors. PG - 18-22, 28 AB - There have been few studies of errors committed in ambulatory care pharmacies. Errors can be classified as incorrect strength, wrong product, wrong dosage form, wrong quantity, incorrect or omitted labeling (such as directions, patient's name, prescriber's name, auxiliary label, drug name, or strength), dispensing deteriorated drugs, and dispensing in non-childproof containers. Errors can be prevented by possessing and using knowledge, by proper performance and by having good systems in effect to prevent and/or uncover errors. Some contributing factors, which cause errors, are distraction and interruption, poor work habits, thoughtless robot-like performance, workloads past the safety threshold, poor working conditions, poorly written and incomplete prescriptions. A prime system to prevent errors from reaching the patient is the old tried and true system of having work checked by another person. The use of patient profiles can aid in reducing errors. The activity of patient counseling can reduce errors. Suggestions are made to reduce the number of errors made. A simple quality assurance program is presented. Case studies of medication errors are presented. The future use of bar-coding should be an extremely useful tool for preventing medication errors. FAU - Davis, N M AU - Davis NM AD - Temple University School of Pharmacy, Philadelphia, PA 19140. LA - eng PT - Journal Article PL - United States TA - Hosp Pharm JT - Hospital pharmacy JID - 0043175 MH - Ambulatory Care/*standards MH - Drug Prescriptions MH - Electronic Data Processing MH - Humans MH - *Medication Errors MH - Pharmaceutical Services/*standards MH - *Quality Assurance, Health Care MH - United States EDAT- 1990/01/01 00:00 MHDA- 1999/04/02 00:01 CRDT- 1990/01/01 00:00 PHST- 1990/01/01 00:00 [pubmed] PHST- 1999/04/02 00:01 [medline] PHST- 1990/01/01 00:00 [entrez] PST - ppublish SO - Hosp Pharm. 1990 Jan;25(1):18-22, 28. PMID- 2573335 OWN - NLM STAT- MEDLINE DCOM- 19891218 LR - 20041117 IS - 0095-6562 (Print) IS - 0095-6562 (Linking) VI - 60 IP - 10 Pt 2 DP - 1989 Oct TI - What the aircrew automated escape system and aircrew life support system equipment designers need from the investigating medical officer and pathologist. PG - B1-10 AB - A major problem apparent in many safety investigation reports concerning aviation mishaps, and especially in their component Flight Surgeon's Reports (FSRs), is the failure of the investigators to recognize needs beyond those of their immediate organizational structures and chains of command in conducting the investigation, and reporting the resultant facts and findings. If aircrew losses and serious injuries are to be reduced, other needs must also be considered and addressed. These additional needs include those of aircrew automated escape system (AAES) and aircrew life support system (ALSS) acquisition personnel who formulate, design, and test requirements, and AAES and ALSS designers and manufacturers who need to know how well and under what conditions of use their equipment is performing. Each mishap, in a sense, constitutes an extremely costly yet highly realistic test of the AAES and ALSS involved. If properly and thoroughly examined, these mishaps will yield exceptionally valuable insights into AAES and ALSS problems and successes and the reasons underlying system behavioral differences. This paper discusses a number of the AAES and ALSS community's needs which investigating medical officers should consider if the U.S. Navy is to gain from these expensive and often tragic mishaps. FAU - Guill, F C AU - Guill FC AD - Crew Systems Division, Naval Air Systems Command, Washington, DC 20361. LA - eng PT - Journal Article PL - United States TA - Aviat Space Environ Med JT - Aviation, space, and environmental medicine JID - 7501714 SB - IM MH - Aerospace Medicine MH - Aircraft/*instrumentation MH - *Communication MH - *Ecological Systems, Closed MH - Equipment Design MH - Humans MH - *Life Support Systems MH - *Military Personnel MH - Naval Medicine MH - *Pathology, Clinical OID - NASA: 90056163 EDAT- 1989/10/01 00:00 MHDA- 1989/10/01 00:01 CRDT- 1989/10/01 00:00 PHST- 1989/10/01 00:00 [pubmed] PHST- 1989/10/01 00:01 [medline] PHST- 1989/10/01 00:00 [entrez] PST - ppublish SO - Aviat Space Environ Med. 1989 Oct;60(10 Pt 2):B1-10. PMID- 39615393 OWN - NLM STAT- MEDLINE DCOM- 20250126 LR - 20250126 IS - 1873-3336 (Electronic) IS - 0304-3894 (Linking) VI - 483 DP - 2025 Feb 5 TI - Heatwaves increase the polystyrene nanoplastic-induced toxicity to marine diatoms through interfacial interaction regulation. PG - 136703 LID - S0304-3894(24)03284-9 [pii] LID - 10.1016/j.jhazmat.2024.136703 [doi] AB - Marine heatwaves, prolonged high-temperature extreme events in the ocean, have increased worldwide in recent decades. Plastic pollution is widespread in the ocean, and the continuous weathering of plastics leads to a substantial release of nanoplastics (NPs). However, the interactive impacts and in-depth mechanisms of heatwaves and NPs on diatoms are largely unknown. Here, we show that a heatwave intensity of 4 °C amplified the toxicity of polystyrene NPs to the globally important diatom Chaetoceros gracilis (C. gracilis), with reductions of 5.62 % and 9.46 % in growth rate and photosynthesis, respectively. Notably, NPs significantly inhibited the cell-specific C assimilation rate by 18.28 % under heatwave conditions. The enhanced NP-induced toxicity to C. gracilis was attributed to decreased mechanical strength and increased NP adsorption under heatwave conditions, which increased membrane damage and oxidative stress. Transcriptomic analysis demonstrated that NPs disturbed redox homeostasis and caused mechanical stress to C. gracilis under heatwave conditions. Moreover, NP treatment downregulated genes (psbA and rbcL) encoding photosynthesis core proteins and the pivotal carbon-fixing enzyme RubisCo under heatwave conditions, resulting in decreased growth and C fixation rates. These findings demonstrate that heatwaves render C. gracilis susceptible to NPs and emphasize the reduced primary productivity caused by NPs under global warming. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Hou, Xuan AU - Hou X AD - Carbon Neutrality Interdisciplinary Science Centre/Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Agro-Environment and Product Safety, Key Laboratory for Environmental Factors Controlling Agro-Product Quality Safety (Ministry of Agriculture and Rural Affairs), Institute of Agro-Environmental Protection, Ministry of Agriculture and Rural Affairs, 300191, Tianjin, China. FAU - Hu, Xiangang AU - Hu X AD - Carbon Neutrality Interdisciplinary Science Centre/Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. FAU - Mu, Li AU - Mu L AD - Tianjin Key Laboratory of Agro-Environment and Product Safety, Key Laboratory for Environmental Factors Controlling Agro-Product Quality Safety (Ministry of Agriculture and Rural Affairs), Institute of Agro-Environmental Protection, Ministry of Agriculture and Rural Affairs, 300191, Tianjin, China. Electronic address: muli@caas.cn. FAU - Wei, Yuanyuan AU - Wei Y AD - Carbon Neutrality Interdisciplinary Science Centre/Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. LA - eng PT - Journal Article DEP - 20241128 PL - Netherlands TA - J Hazard Mater JT - Journal of hazardous materials JID - 9422688 RN - 0 (Polystyrenes) RN - 0 (Water Pollutants, Chemical) RN - 0 (Microplastics) SB - IM MH - *Diatoms/drug effects/growth & development MH - *Polystyrenes/toxicity/chemistry MH - *Hot Temperature MH - Photosynthesis/drug effects MH - Water Pollutants, Chemical/toxicity MH - Nanoparticles/toxicity/chemistry MH - Microplastics/toxicity MH - Oxidative Stress/drug effects OTO - NOTNLM OT - Carbon fixation OT - Diatoms OT - Heatwaves OT - Nanoplastics OT - Photosynthesis COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/12/01 15:22 MHDA- 2025/01/27 00:20 CRDT- 2024/11/30 18:11 PHST- 2024/09/17 00:00 [received] PHST- 2024/11/12 00:00 [revised] PHST- 2024/11/26 00:00 [accepted] PHST- 2025/01/27 00:20 [medline] PHST- 2024/12/01 15:22 [pubmed] PHST- 2024/11/30 18:11 [entrez] AID - S0304-3894(24)03284-9 [pii] AID - 10.1016/j.jhazmat.2024.136703 [doi] PST - ppublish SO - J Hazard Mater. 2025 Feb 5;483:136703. doi: 10.1016/j.jhazmat.2024.136703. Epub 2024 Nov 28. PMID- 23603219 OWN - NLM STAT- MEDLINE DCOM- 20130925 LR - 20181202 IS - 1879-3460 (Electronic) IS - 0168-1605 (Linking) VI - 164 IP - 1 DP - 2013 Jun 3 TI - In-situ immuno-gold nanoparticle network ELISA biosensors for pathogen detection. PG - 70-5 LID - S0168-1605(13)00134-7 [pii] LID - 10.1016/j.ijfoodmicro.2013.02.025 [doi] AB - Food poisoning microorganisms that contaminate food products and compromise food safety and security have been considered a major health threat and a serious concern for food producers and processors. Developing sensor technologies that are rapid for sensitive and selective detection and quantification of pathogens is a high priority for scientists in academia, state and federal research institutes, and industries. In this work we propose an in-situ immuno-AuNP network-based ELISA biosensor integrated with a sample concentration step based on immuno-magnetic separation to detect pathogenic microorganisms with high sensitivity. The sensor system was optimized by the specific formation of immuno-AuNP network onto the antigenic site present at the outer membrane surface of bacteria and the analytical concept was validated by a microtiter immunoassay. The in-situ network biosensor was able to detect pathogens at extremely low numbers: 3 cells/mL of Escherichia coli O157:H7 and Salmonella typhimurium in buffer and 3 CFU/mL of E. coli O157:H7 and 15CFU/mL of S. typhimurium in real sample conditions within 2h of inoculation. The ability to monitor target bacteria with improved analytical sensitivity compared to the current techniques presents a unique opportunity for routine monitoring to improve the safety of foods. CI - Copyright © 2013 Elsevier B.V. All rights reserved. FAU - Cho, Il-Hoon AU - Cho IH AD - Bindley Bioscience and Birck Nanotechnology Center, Department of Agricultural & Biological Engineering, Purdue University, West Lafayette, IN 47907, United States. FAU - Irudayaraj, Joseph AU - Irudayaraj J LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20130314 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 RN - 7440-57-5 (Gold) SB - IM MH - Biosensing Techniques/*instrumentation MH - *Enzyme-Linked Immunosorbent Assay MH - Escherichia coli O157/physiology MH - Food Microbiology/*methods MH - Food Safety/*methods MH - Gold/*chemistry MH - Immunoassay/*instrumentation MH - Nanoparticles/*chemistry MH - Salmonella typhimurium/physiology MH - Sensitivity and Specificity EDAT- 2013/04/23 06:00 MHDA- 2013/09/26 06:00 CRDT- 2013/04/23 06:00 PHST- 2012/09/10 00:00 [received] PHST- 2013/02/22 00:00 [revised] PHST- 2013/02/25 00:00 [accepted] PHST- 2013/04/23 06:00 [entrez] PHST- 2013/04/23 06:00 [pubmed] PHST- 2013/09/26 06:00 [medline] AID - S0168-1605(13)00134-7 [pii] AID - 10.1016/j.ijfoodmicro.2013.02.025 [doi] PST - ppublish SO - Int J Food Microbiol. 2013 Jun 3;164(1):70-5. doi: 10.1016/j.ijfoodmicro.2013.02.025. Epub 2013 Mar 14. PMID- 32175231 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240328 IS - 2223-3652 (Print) IS - 2223-3660 (Electronic) IS - 2223-3652 (Linking) VI - 10 IP - 1 DP - 2020 Feb TI - Current state of transcatheter tricuspid valve repair. PG - 89-97 LID - 10.21037/cdt.2019.09.11 [doi] AB - Tricuspid regurgitation (TR) is a common valvular heart disease affecting >1.6 million people in the United States (US) and >70 million people worldwide. The age- and sex-adjusted prevalence of more than or equal to moderate TR in the US is estimated to be 0.55%. One-year mortality increases with increasing severity of TR. Yet, the majority of patients with severe TR are managed medically in the absence of another indication for cardiac surgery, and isolated tricuspid valve (TV) surgery remains infrequent. To address this unmet clinical need, various transcatheter TV therapies are now being developed as an alternative to surgery in extreme- and high-risk patients with severe functional TR. Transcatheter TV repair devices are aimed at improving leaflet coaptation either directly by bringing the leaflets together (leaflet/coaptation devices) or indirectly by repairing the dilated annulus (annuloplasty devices). In this review, we describe the current state of transcatheter TV repair therapies and summarize the available data on the efficacy and safety of various devices. Procedural and clinical outcomes of transcatheter TV repair therapies are expected to improve in the coming years with technological advancement, newer device iterations, and increased experience in this field. Appropriate patient selection, optimal timing of intervention, and evaluation of long-term outcomes and device durability will be key in ongoing and future studies. CI - 2020 Cardiovascular Diagnosis and Therapy. All rights reserved. FAU - Kolte, Dhaval AU - Kolte D AD - Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. FAU - Elmariah, Sammy AU - Elmariah S AD - Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. LA - eng PT - Journal Article PT - Review PL - China TA - Cardiovasc Diagn Ther JT - Cardiovascular diagnosis and therapy JID - 101601613 PMC - PMC7044094 OTO - NOTNLM OT - TV OT - Tricuspid regurgitation (TR) OT - transcatheter tricuspid valve repair (transcatheter TV repair) OT - tricuspid insufficiency COIS- Conflicts of Interest: The authors have no conflicts of interest to declare. EDAT- 2020/03/17 06:00 MHDA- 2020/03/17 06:01 PMCR- 2020/02/01 CRDT- 2020/03/17 06:00 PHST- 2020/03/17 06:00 [entrez] PHST- 2020/03/17 06:00 [pubmed] PHST- 2020/03/17 06:01 [medline] PHST- 2020/02/01 00:00 [pmc-release] AID - cdt-10-01-89 [pii] AID - 10.21037/cdt.2019.09.11 [doi] PST - ppublish SO - Cardiovasc Diagn Ther. 2020 Feb;10(1):89-97. doi: 10.21037/cdt.2019.09.11. PMID- 38514026 OWN - NLM STAT- MEDLINE DCOM- 20240603 LR - 20240603 IS - 2452-0748 (Electronic) IS - 2452-0748 (Linking) VI - 34 DP - 2024 Apr TI - Assessment of TiO(2) (nano)particles migration from food packaging materials to food simulants by single particle ICP-MS/MS using a high efficiency sample introduction system. PG - 100503 LID - S2452-0748(24)00013-2 [pii] LID - 10.1016/j.impact.2024.100503 [doi] AB - TiO(2) is the most widely used white pigment in plastics and food packaging industry, thus the question of its migration towards food and hence the impact on consumers is raised. Since recent research indicate its potential toxicity, it is necessary to study TiO(2) contamination as a consequence of food storage. For this purpose, plastic containers from commercially-available dairy products and custom-made TiO(2)-spiked polypropylene materials were put in contact with 50% (v/v) ethanol and 3% (w/v) acetic acid, which were used here as food simulants. The migration assays were carried out under standard contact conditions of packaging use (as recommended by Commission Regulation (EU) N° 10/2011 for food contact migration testing), and under conditions of extreme mechanical degradation of the packaging. The TiO(2) (nano)particles released in the food simulants were analysed by single particle inductively coupled plasma-tandem mass spectrometry in mass-shift mode and using a high efficiency sample introduction system (APEX™ Ω) to avoid matrix effects from food simulants. For the dairy product containers and for the spiked polypropylene, results showed release of TiO(2) particles of rather large sizes (average size: 164 and 175 nm, respectively) under mechanical degradation conditions, i.e. when the polymeric structure is damaged. The highest amounts of TiO(2) were observed in 50% ethanol after 10 days of storage at 50 °C (0.62 ng cm(-2)) for the dairy product containers and after 1 day of storage at 50 °C (0.68 ng cm(-2)) for the spiked polypropylene. However, the level of Ti released in particle form was very small compared to the total Ti content in the packaging and far below the acceptable migration limits set by European legislation. Release under standard contact conditions of use of the container was not measurable, thus the migration of TiO(2) particles from this packaging to dairy products among storage is expected to be negligible. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Bastardo-Fernández, Isabel AU - Bastardo-Fernández I AD - Laboratory for Food Safety, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Université Paris-Est, 94700 Maisons-Alfort, France; LNE, Environment and Climate Change Department, Paris, France. FAU - Chekri, Rachida AU - Chekri R AD - Laboratory for Food Safety, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Université Paris-Est, 94700 Maisons-Alfort, France. FAU - Oster, Caroline AU - Oster C AD - LNE, Environment and Climate Change Department, Paris, France. FAU - Thoury, Valentin AU - Thoury V AD - IPC, Industrial Technical Centre for Plastics and Composites, Alençon, France. FAU - Fisicaro, Paola AU - Fisicaro P AD - LNE, Division of Chemistry and Biology, Paris, France. FAU - Jitaru, Petru AU - Jitaru P AD - Laboratory for Food Safety, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Université Paris-Est, 94700 Maisons-Alfort, France. FAU - Noireaux, Johanna AU - Noireaux J AD - LNE, Environment and Climate Change Department, Paris, France. Electronic address: johanna.noireaux@lne.fr. LA - eng PT - Journal Article DEP - 20240320 PL - Netherlands TA - NanoImpact JT - NanoImpact JID - 101676795 RN - 15FIX9V2JP (titanium dioxide) RN - D1JT611TNE (Titanium) RN - 0 (Polypropylenes) SB - IM MH - *Titanium/analysis/chemistry MH - *Food Packaging MH - *Food Contamination/analysis MH - *Tandem Mass Spectrometry MH - Polypropylenes/chemistry/analysis MH - Particle Size MH - Nanoparticles/analysis/adverse effects OTO - NOTNLM OT - Food packaging OT - Migration OT - Single particle ICP-MS/MS OT - TiO(2) nanoparticles COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/03/22 00:44 MHDA- 2024/06/04 00:45 CRDT- 2024/03/21 20:31 PHST- 2023/11/27 00:00 [received] PHST- 2024/03/18 00:00 [revised] PHST- 2024/03/18 00:00 [accepted] PHST- 2024/06/04 00:45 [medline] PHST- 2024/03/22 00:44 [pubmed] PHST- 2024/03/21 20:31 [entrez] AID - S2452-0748(24)00013-2 [pii] AID - 10.1016/j.impact.2024.100503 [doi] PST - ppublish SO - NanoImpact. 2024 Apr;34:100503. doi: 10.1016/j.impact.2024.100503. Epub 2024 Mar 20. PMID- 33098135 OWN - NLM STAT- MEDLINE DCOM- 20210708 LR - 20210708 IS - 1537-2995 (Electronic) IS - 0041-1132 (Linking) VI - 61 IP - 2 DP - 2021 Feb TI - Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency. PG - 494-502 LID - 10.1111/trf.16144 [doi] AB - BACKGROUND: The standard approach to estimating HIV incidence in repeat blood donors includes only donors who made two or more donations in an estimation interval. In China and some other countries, large proportions of repeat donors donate only once in a 1- or 2-year interval. The standard approach may not represent risk among all repeat donors in these areas. Two approaches to including all repeat donors in the incidence estimate were evaluated in a simulation study. STUDY DESIGN AND METHODS: Under one approach, a donor infected at the first donation contributes a partial case to incidence that equals the proportion of time since the preceding donation that is in the estimation interval. Under the other, that donor contributes a full case if at least half the time since the previous donation is in the estimation interval and nothing otherwise. Infections identified at the second or subsequent donations in the interval contribute full cases as usual. The simulations involved proportions with single donations of 11% to 65% combined with a variety of patterns of rising, falling, or constant incidence. RESULTS: The partial-case approach was unbiased under more test conditions than the whole-case approach and exhibited smaller bias when both were biased. Under both approaches, bias >10% occurred only when rates of single donations >50% were combined with large changes in incidence over time. CONCLUSION: The partial-case approach performed better than the whole-case approach. The conditions producing bias >10% are so extreme that they are unlikely to be encountered in the field. CI - © 2020 AABB. FAU - Brambilla, Donald J AU - Brambilla DJ AUID- ORCID: 0000-0002-7276-4689 AD - RTI International, Rockville, Maryland, USA. FAU - Busch, Michael P AU - Busch MP AD - Vitalant Research Institute, San Francisco, California, USA. FAU - Glynn, Simone A AU - Glynn SA AD - Blood Epidemiology and Clinical Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. FAU - Kleinman, Steven H AU - Kleinman SH AD - Department of Pathology, University of British Columbia, Victoria, British Columbia, Canada. CN - NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) LA - eng GR - HHSN268201100009I/HL/NHLBI NIH HHS/United States GR - HHSN268201100008I/HL/NHLBI NIH HHS/United States GR - HHSN268201100007I/HL/NHLBI NIH HHS/United States GR - HHSN268201100002I/HL/NHLBI NIH HHS/United States GR - HHSN268201100001I/HL/NHLBI NIH HHS/United States GR - HHSN268201100009I/HL/NHLBI NIH HHS/United States GR - HHSN268201100008I/HL/NHLBI NIH HHS/United States GR - HHSN268201100007I/HL/NHLBI NIH HHS/United States GR - HHSN268201100002I/HL/NHLBI NIH HHS/United States GR - HHSN268201100001I/HL/NHLBI NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201024 PL - United States TA - Transfusion JT - Transfusion JID - 0417360 SB - IM MH - Bias MH - *Blood Donors/statistics & numerical data MH - Blood Safety/*methods MH - China/epidemiology MH - Cohort Studies MH - Computer Simulation MH - Follow-Up Studies MH - HIV Infections/*epidemiology MH - Humans MH - Incidence MH - Models, Theoretical OTO - NOTNLM OT - HIV infection OT - blood donors OT - incidence OT - interdonation interval EDAT- 2020/10/25 06:00 MHDA- 2021/07/09 06:00 CRDT- 2020/10/24 05:36 PHST- 2020/05/21 00:00 [received] PHST- 2020/09/09 00:00 [revised] PHST- 2020/09/09 00:00 [accepted] PHST- 2020/10/25 06:00 [pubmed] PHST- 2021/07/09 06:00 [medline] PHST- 2020/10/24 05:36 [entrez] AID - 10.1111/trf.16144 [doi] PST - ppublish SO - Transfusion. 2021 Feb;61(2):494-502. doi: 10.1111/trf.16144. Epub 2020 Oct 24. PMID- 21389185 OWN - NLM STAT- MEDLINE DCOM- 20111209 LR - 20220411 IS - 1552-3365 (Electronic) IS - 0363-5465 (Linking) VI - 39 IP - 7 DP - 2011 Jul TI - A prospective study of snowkiting injuries. PG - 1534-40 LID - 10.1177/0363546511398214 [doi] AB - BACKGROUND: Snowkiting is becoming an increasingly popular extreme sport; however, its injury rates and patterns are unknown to date. PURPOSE: The authors surveyed the injuries in a group of snowkiters over 1 season. STUDY DESIGN: Descriptive epidemiology study. METHODS: The study was conducted over the course of 1 winter season ranging from November 2009 until March 2010; 80 snowkiters were surveyed prospectively. All participants were recruited through contacts with snowkite schools, snowkiting-related web portals, or Internet-based social networks. RESULTS: During 3929 hours of snowkiting recorded, 33 injuries occurred, of which 60.6% were mild; 21.2%, moderate; and 18.2%, severe. The calculated injury rate was 8.4 injuries per 1000 hours of exposure. Most frequently injured body sites were the back (30.3%), knee (24.2%), shoulder (21.2%), and head (21.2%). Upper extremity injuries included 2 shoulder dislocations, a clavicle fracture, and a dislocation fracture of the radial head. Injuries to the lower extremity included 3 knee sprains and 1 anterior cruciate ligament rupture. The most common injury causes were riding errors (75.8%), wind gusts (36.4%), and poor snow conditions (27.3%). When compared with experts (5.1 injuries per 1000 hours of exposure), beginners (20.8 injuries per 1000 hours of exposure) had a significantly increased risk of getting injured (odds ratio [OR] 4.11; 95% confidence interval [CI], 1.34-12.64; P = .008). Athletes who used snowboards for snowkiting purposes were injured almost 3 times more frequently than their colleagues using skis (11.7 vs 4.1 injuries per 1000 hours of exposure; OR 2.85; 95% CI, 1.23-6.57; P = .010). The quick-release system (97.5%), helmet (92.5%), kite leash (83.8%), spine protector (51.3%), and shoulder protectors (20.0%) were the most commonly used protective/safety equipment. CONCLUSION: Snowkiting can be considered a sport carrying a high risk of injury. More caution in assessing local snow conditions and wind gust occurrences is recommended as well as considering using the help and advice of a professional instructor when beginning this action-packed sport. Injury prevention strategies should also include the further improvement of currently available safety equipment. FAU - Moroder, Philipp AU - Moroder P AD - Department of Traumatology and Sports Injuries, Paracelsus Medical University, Salzburg, Austria. philipp.moroder@pmu.ac.at FAU - Runer, Armin AU - Runer A FAU - Hoffelner, Thomas AU - Hoffelner T FAU - Frick, Nora AU - Frick N FAU - Resch, Herbert AU - Resch H FAU - Tauber, Mark AU - Tauber M LA - eng PT - Journal Article DEP - 20110309 PL - United States TA - Am J Sports Med JT - The American journal of sports medicine JID - 7609541 SB - IM MH - Adolescent MH - Adult MH - Back Injuries/*epidemiology MH - Child MH - Humans MH - Incidence MH - Knee Injuries/*epidemiology MH - Male MH - Middle Aged MH - Prospective Studies MH - Protective Devices MH - Risk Factors MH - *Shoulder Injuries MH - Snow Sports/*injuries EDAT- 2011/03/11 06:00 MHDA- 2011/12/14 06:00 CRDT- 2011/03/11 06:00 PHST- 2011/03/11 06:00 [entrez] PHST- 2011/03/11 06:00 [pubmed] PHST- 2011/12/14 06:00 [medline] AID - 0363546511398214 [pii] AID - 10.1177/0363546511398214 [doi] PST - ppublish SO - Am J Sports Med. 2011 Jul;39(7):1534-40. doi: 10.1177/0363546511398214. Epub 2011 Mar 9. PMID- 4639404 OWN - NLM STAT- MEDLINE DCOM- 19730208 LR - 20190501 IS - 0017-5749 (Print) IS - 1458-3288 (Electronic) IS - 0017-5749 (Linking) VI - 13 IP - 9 DP - 1972 Sep TI - Antidepressants and liver disease. PG - 697-701 AB - Patients with cirrhosis were found to be extremely sensitive to tranylcypromine, and the use of this drug for the treatment of depression in such patients is contraindicated. Amitriptyline has a wider margin of safety in such patients, but caution is necessary when the higher therapeutic doses are prescribed. FAU - Morgan, M H AU - Morgan MH FAU - Read, A E AU - Read AE LA - eng PT - Journal Article PL - England TA - Gut JT - Gut JID - 2985108R RN - 01Q9PC255D (Ammonium Chloride) RN - 1806D8D52K (Amitriptyline) RN - 3E3V44J4Z9 (Tranylcypromine) RN - 7664-41-7 (Ammonia) SB - IM MH - Amitriptyline/therapeutic use MH - Ammonia/blood MH - Ammonium Chloride/metabolism MH - Depression/complications/*drug therapy MH - Electroencephalography MH - Humans MH - Liver Cirrhosis/*complications/metabolism MH - Nervous System Diseases/complications/drug therapy MH - Sleep MH - Tranylcypromine/*adverse effects/therapeutic use PMC - PMC1412380 EDAT- 1972/09/01 00:00 MHDA- 1972/09/01 00:01 PMCR- 1972/09/01 CRDT- 1972/09/01 00:00 PHST- 1972/09/01 00:00 [pubmed] PHST- 1972/09/01 00:01 [medline] PHST- 1972/09/01 00:00 [entrez] PHST- 1972/09/01 00:00 [pmc-release] AID - 10.1136/gut.13.9.697 [doi] PST - ppublish SO - Gut. 1972 Sep;13(9):697-701. doi: 10.1136/gut.13.9.697. PMID- 33120649 OWN - NLM STAT- MEDLINE DCOM- 20201106 LR - 20210111 IS - 1998-3689 (Electronic) IS - 0301-4738 (Print) IS - 0301-4738 (Linking) VI - 68 IP - 11 DP - 2020 Nov TI - Safe Slit-lamp Shield: Maintaining a balance between ergonomics and safety. PG - 2486-2489 LID - 10.4103/ijo.IJO_2325_20 [doi] AB - Since the emergence of COVID pandemic, health workers have been facing major challenges every day. Ophthalmology practice has encountered countless modifications in the practice pattern not to jeopardize patient care and at the same time maintain all safety measures to reduce transmission. One such modification we made was the Safe Slit-Lamp Shield (SSS) which has been found to be extremely protective in differentiation to other available shield. Although SSS has a larger surface area when compared to already available shields, it won't compromise the comfort of the clinician at the same time gives satisfactory protection. FAU - Khadia, Anjali AU - Khadia A AD - Department of Pediatric Ophthalmology and Strabismus, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. FAU - Nachiappan, Sivagami AU - Nachiappan S AD - Medical Officer, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. FAU - Kalita, Iva R AU - Kalita IR AD - Department of Pediatric Ophthalmology and Strabismus, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. FAU - Singh, Harsh Vardhan AU - Singh HV AD - Department of Retina and Vitreous, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. FAU - Vedachalam, Rajesh AU - Vedachalam R AD - Cornea and Refractive Surgery, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. FAU - Venkatesh, Rengaraj AU - Venkatesh R AD - Chief Medical Officer, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India. LA - eng PT - Journal Article PL - India TA - Indian J Ophthalmol JT - Indian journal of ophthalmology JID - 0405376 RN - 0 (Acrylic Resins) RN - 0 (Aerosols) SB - IM MH - Acrylic Resins MH - Aerosols MH - *Betacoronavirus MH - COVID-19 MH - Coronavirus Infections/*transmission MH - Equipment Design MH - *Equipment Safety MH - *Ergonomics MH - Humans MH - Infectious Disease Transmission, Patient-to-Professional/*prevention & control MH - Pandemics MH - Pneumonia, Viral/*transmission MH - *Protective Devices MH - SARS-CoV-2 MH - Slit Lamp MH - Slit Lamp Microscopy/*instrumentation PMC - PMC7774222 OTO - NOTNLM OT - Aerosol OT - COVID -19 OT - Shield OT - Slit-lamp COIS- None EDAT- 2020/10/31 06:00 MHDA- 2020/11/11 06:00 PMCR- 2020/11/01 CRDT- 2020/10/30 01:01 PHST- 2020/10/30 01:01 [entrez] PHST- 2020/10/31 06:00 [pubmed] PHST- 2020/11/11 06:00 [medline] PHST- 2020/11/01 00:00 [pmc-release] AID - IndianJOphthalmol_2020_68_11_2486_299053 [pii] AID - IJO-68-2486 [pii] AID - 10.4103/ijo.IJO_2325_20 [doi] PST - ppublish SO - Indian J Ophthalmol. 2020 Nov;68(11):2486-2489. doi: 10.4103/ijo.IJO_2325_20. PMID- 34785054 OWN - NLM STAT- MEDLINE DCOM- 20211216 LR - 20211216 IS - 1095-7103 (Electronic) IS - 0021-9797 (Linking) VI - 608 IP - Pt 3 DP - 2022 Feb 15 TI - In situ immobilization of silver nanocrystals in carbon nanoparticles for intracellular fluorescence imaging and hydroxyl radicals detection. PG - 2672-2680 LID - S0021-9797(21)01885-3 [pii] LID - 10.1016/j.jcis.2021.10.195 [doi] AB - Silver nanoparticles (Ag NPs) have attracted extensive research interest in bioimaging and biosensing due to their unique surface plasmon resonance. However, the potential aggregation and security anxiety of Ag NPs hinder their further application in biomedical field due to their high surface energy and the possible ionization. Here, binary heterogeneous nanocomplexes constructed from silver nanoparticles and carbon nanomaterials (termed as C-Ag NPs) were reported. The C-Ag NPs with multiple yolk structure were synthesized via a one-step solvothermal route using toluene as carbon precursor and dispersant. The hydrophilic functional groups on the carbon layer endowed the C-Ag NPs excellent chemical stability and water-dispersity. Results showed that C-Ag NPs demonstrated excellent safety profile and excellent biocompatibility, which could be used as an intracellular imaging agent. Moreover, the C-Ag NPs responded specifically to hydroxyl radicals and were expected to serve as a flexible sensor to efficiently detect diseases related to the expression of hydroxyl radicals in the future. CI - Copyright © 2021 Elsevier Inc. All rights reserved. FAU - Wang, Ruyu AU - Wang R AD - Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, PR China. FAU - Liu, Hongji AU - Liu H AD - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China; University of Science and Technology of China, Hefei 230026, Anhui, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China. FAU - Meng, Xiangfu AU - Meng X AD - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China; University of Science and Technology of China, Hefei 230026, Anhui, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China. FAU - Qian, Yong AU - Qian Y AD - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China. FAU - Wang, Xingyu AU - Wang X AD - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China; University of Science and Technology of China, Hefei 230026, Anhui, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China. FAU - Zhu, Feng AU - Zhu F AD - Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, PR China. Electronic address: drzf@nju.edu.cn. FAU - Nie, Rongrong AU - Nie R AD - Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, Jiangsu, PR China. Electronic address: nrr63@nju.edu.cn. FAU - Wang, Hui AU - Wang H AD - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, PR China. Electronic address: hw39@hmfl.ac.cn. LA - eng PT - Journal Article DEP - 20211106 PL - United States TA - J Colloid Interface Sci JT - Journal of colloid and interface science JID - 0043125 RN - 3352-57-6 (Hydroxyl Radical) RN - 3M4G523W1G (Silver) RN - 7440-44-0 (Carbon) SB - IM MH - Carbon MH - Hydroxyl Radical MH - *Metal Nanoparticles MH - Optical Imaging MH - *Silver OTO - NOTNLM OT - Bioimaging OT - Biosensor OT - Carbon OT - Core–shell nanostructure OT - Silver nanoparticles COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2021/11/18 06:00 MHDA- 2021/12/17 06:00 CRDT- 2021/11/17 05:45 PHST- 2021/06/20 00:00 [received] PHST- 2021/10/02 00:00 [revised] PHST- 2021/10/31 00:00 [accepted] PHST- 2021/11/18 06:00 [pubmed] PHST- 2021/12/17 06:00 [medline] PHST- 2021/11/17 05:45 [entrez] AID - S0021-9797(21)01885-3 [pii] AID - 10.1016/j.jcis.2021.10.195 [doi] PST - ppublish SO - J Colloid Interface Sci. 2022 Feb 15;608(Pt 3):2672-2680. doi: 10.1016/j.jcis.2021.10.195. Epub 2021 Nov 6. PMID- 30205800 OWN - NLM STAT- MEDLINE DCOM- 20190111 LR - 20200225 IS - 1875-6336 (Electronic) IS - 1573-3963 (Print) IS - 1573-3963 (Linking) VI - 14 IP - 4 DP - 2018 TI - The Therapeutic Potential of Stem Cells for Bronchopulmonary Dysplasia: "It's About Time" or "Not so Fast" ? PG - 227-238 LID - 10.2174/1573396314666180911100503 [doi] AB - OBJECTIVE: While the survival of extremely premature infants has improved over the past decades, the rate of complications - especially for bronchopulmonary dysplasia (BPD) - remains unacceptably high. Over the past 50 years, no safe therapy has had a substantial impact on the incidence and severity of BPD. METHODS: This may stem from the multifactorial disease pathogenesis and the increasing lung immaturity. Mesenchymal Stromal Cells (MSCs) display pleiotropic effects and show promising results in neonatal rodents in preventing or rescuing lung injury without adverse effects. Early phase clinical trials are now underway to determine the safety and efficacy of this therapy in extremely premature infants. RESULTS AND CONCLUSION: This review summarizes our current knowledge about MSCs, their mechanism of action and the results of preclinical studies that provide the rationale for early phase clinical trials and discuss remaining gaps in our knowledge. CI - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Ee, Mong Tieng AU - Ee MT AD - Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, ON, Canada. FAU - Thébaud, Bernard AU - Thébaud B AD - Division of Neonatology, Department of Pediatrics, Children's Hospital of Eastern Ontario (CHEO) and CHEO Research Institute, Ottawa, ON, Canada. AD - Sinclair Centre for Regenerative Medicine, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada. AD - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article PT - Review PL - United Arab Emirates TA - Curr Pediatr Rev JT - Current pediatric reviews JID - 101240290 SB - IM MH - Animals MH - Bronchopulmonary Dysplasia/*therapy MH - Humans MH - Infant, Extremely Premature MH - Infant, Newborn MH - Mesenchymal Stem Cell Transplantation/adverse effects/*methods MH - Mesenchymal Stem Cells/*cytology PMC - PMC6416190 OTO - NOTNLM OT - MSCs OT - Therapeutic potential OT - angiogenesis OT - bronchopulmonary OT - dysplasia OT - stem cells. EDAT- 2018/09/13 06:00 MHDA- 2019/01/12 06:00 PMCR- 2019/03/14 CRDT- 2018/09/13 06:00 PHST- 2018/03/19 00:00 [received] PHST- 2018/08/09 00:00 [revised] PHST- 2018/09/10 00:00 [accepted] PHST- 2018/09/13 06:00 [pubmed] PHST- 2019/01/12 06:00 [medline] PHST- 2018/09/13 06:00 [entrez] PHST- 2019/03/14 00:00 [pmc-release] AID - CPR-EPUB-92935 [pii] AID - CPR-14-227 [pii] AID - 10.2174/1573396314666180911100503 [doi] PST - ppublish SO - Curr Pediatr Rev. 2018;14(4):227-238. doi: 10.2174/1573396314666180911100503. PMID- 36802397 OWN - NLM STAT- MEDLINE DCOM- 20230309 LR - 20230309 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 20 IP - 2 DP - 2023 Feb TI - Safety and effectiveness of monovalent COVID-19 mRNA vaccination and risk factors for hospitalisation caused by the omicron variant in 0.8 million adolescents: A nationwide cohort study in Sweden. PG - e1004127 LID - 10.1371/journal.pmed.1004127 [doi] LID - e1004127 AB - BACKGROUND: Real-world evidence on the safety and effectiveness of Coronavirus Disease 2019 (COVID-19) vaccination against severe disease caused by the omicron variant among adolescents is sparse. In addition, evidence on risk factors for severe COVID-19 disease, and whether vaccination is similarly effective in such risk groups, is unclear. The aim of the present study was therefore to examine the safety and effectiveness of monovalent COVID-19 mRNA vaccination against COVID-19 hospitalisation, and risk factors for COVID-19 hospitalisation in adolescents. METHODS AND FINDINGS: A cohort study was conducted using Swedish nationwide registers. The safety analysis included all individuals in Sweden born between 2003 and 2009 (aged 11.3 to 19.2 years) given at least 1 dose of monovalent mRNA vaccine (N = 645,355), and never vaccinated controls (N = 186,918). The outcomes included all-cause hospitalisation and 30 selected diagnoses until 5 June 2022. The vaccine effectiveness (VE) against COVID-19 hospitalisation, and risk factors for hospitalisation, were evaluated in adolescents given 2 doses of monovalent mRNA vaccine (N = 501,945), as compared to never vaccinated controls (N = 157,979), for up to 5 months follow-up during an omicron predominant period (1 January 2022 to 5 June 2022). Analyses were adjusted for age, sex, baseline date, and whether the individual was born in Sweden. The safety analysis showed that vaccination was associated with 16% lower (95% confidence interval (CI) [12, 19], p < 0.001) risk of all-cause hospitalisation, and with marginal differences between the groups regarding the 30 selected diagnoses. In the VE analysis, there were 21 cases (0.004%) of COVID-19 hospitalisation among 2-dose recipients and 26 cases (0.016%) among controls, resulting in a VE of 76% (95% CI [57, 87], p < 0.001). Predominant risk factors for COVID-19 hospitalisation included previous infections (bacterial infection, tonsillitis, and pneumonia) (odds ratio [OR]: 14.3, 95% CI [7.7, 26.6], p < 0.001), and cerebral palsy/development disorders (OR: 12.7, 95% CI [6.8, 23.8], p < 0.001), with similar estimates of VE in these subgroups as in the total cohort. The number needed to vaccinate with 2 doses to prevent 1 case of COVID-19 hospitalisation was 8,147 in the total cohort and 1,007 in those with previous infections or developmental disorders. None of the individuals hospitalised due to COVID-19 died within 30 days. Limitations of this study include the observational design and the possibility of unmeasured confounding. CONCLUSIONS: In this nationwide study of Swedish adolescents, monovalent COVID-19 mRNA vaccination was not associated with an increased risk of any serious adverse events resulting in hospitalisation. Vaccination with 2 doses was associated with a lower risk of COVID-19 hospitalisation during an omicron predominant period, also among those with certain predisposing conditions who should be prioritised for vaccination. However, COVID-19 hospitalisation in the general population of adolescents was extremely rare, and additional doses in this population may not be warranted at this stage. CI - Copyright: © 2023 Nordström et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Nordström, Peter AU - Nordström P AUID- ORCID: 0000-0003-2924-508X AD - Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden. AD - Department of Community Medicine and Rehabilitation, Unit of Geriatric Medicine, Umeå University, Umeå, Sweden. FAU - Ballin, Marcel AU - Ballin M AUID- ORCID: 0000-0002-9638-7208 AD - Department of Community Medicine and Rehabilitation, Unit of Geriatric Medicine, Umeå University, Umeå, Sweden. FAU - Nordström, Anna AU - Nordström A AUID- ORCID: 0000-0003-3534-456X AD - Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden. AD - School of Sport Sciences, UiT the Arctic University of Norway, Tromsø, Norway. LA - eng PT - Journal Article PT - Observational Study DEP - 20230221 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 RN - 0 (RNA, Messenger) RN - SARS-CoV-2 variants SB - IM MH - Humans MH - Adolescent MH - *COVID-19/epidemiology/prevention & control MH - Sweden/epidemiology MH - Cohort Studies MH - SARS-CoV-2 MH - Risk Factors MH - Hospitalization MH - RNA, Messenger PMC - PMC9990916 COIS- The authors have declared that no competing interests exist. EDAT- 2023/02/22 06:00 MHDA- 2023/03/10 06:00 PMCR- 2023/02/21 CRDT- 2023/02/21 17:12 PHST- 2022/10/18 00:00 [received] PHST- 2023/01/30 00:00 [accepted] PHST- 2023/03/07 00:00 [revised] PHST- 2023/02/22 06:00 [pubmed] PHST- 2023/03/10 06:00 [medline] PHST- 2023/02/21 17:12 [entrez] PHST- 2023/02/21 00:00 [pmc-release] AID - PMEDICINE-D-22-03429 [pii] AID - 10.1371/journal.pmed.1004127 [doi] PST - epublish SO - PLoS Med. 2023 Feb 21;20(2):e1004127. doi: 10.1371/journal.pmed.1004127. eCollection 2023 Feb. PMID- 24520910 OWN - NLM STAT- MEDLINE DCOM- 20141009 LR - 20211021 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 14 DP - 2014 Feb 12 TI - German adaptation of the Resources for Enhancing Alzheimer's Caregiver Health II: study protocol of a single-centred, randomised controlled trial. PG - 21 LID - 10.1186/1471-2318-14-21 [doi] AB - BACKGROUND: Caring for a family member with dementia is extremely stressful, and contributes to psychiatric and physical illness among caregivers. Therefore, a comprehensive programme called Resources for Enhancing Alzheimer's Caregiver Health II (REACH II) was developed in the United States to enhance the health of Alzheimer's caregivers. REACH II causes a clear reduction of the stress and burdens faced by informal caregivers at home. The aim of this protocol is to adapt, apply, and evaluate this proven intervention programme in a German-speaking area for the first time. This newly adapted intervention is called Deutsche Adaption der Resources for Enhancing Alzheimer's Caregiver Health (DeREACH). METHODS: A total of 138 informal caregivers at home are recruited in a single-centred, randomised controlled trial. The intervention (DeREACH) consists of nine home visits and three telephone contacts over six months, all of which focus on safety, psychological well-being and self-care, social support, problem behaviour and preventive health-related behaviours. A complex intervention assessment on effectiveness will be adopted when the primary outcome - namely, the reduction of caregiver burden - and other secondary outcomes, including changes with regard to anxiety and depression, somatisation, health-related quality of life, and perceived social support, are measured at baseline, as well as immediately and three months after the intervention. The change from baseline to post-intervention assessment with regard to the primary outcome will be compared between treatment and control group using t-tests for independent samples. DISCUSSION: It is anticipated that this study will show that DeREACH effectively reduces caregiver burden and therefore works under the conditions of a local German health-care system. If successful, this programme will provide an effective intervention programme in the German-speaking area to identify and develop the personal capabilities of informal caregivers to cope with the burdens of caring for people with dementia. FAU - Heinrich, Stephanie AU - Heinrich S AD - Clinic and Policlinic for Psychiatry and Psychotherapy, Leipzig University, Semmelweisstr, 10, 04103 Leipzig, Germany. Stephanie.Heinrich@medizin.uni-leipzig.de. FAU - Berwig, Martin AU - Berwig M FAU - Simon, Anke AU - Simon A FAU - Jänichen, Jenny AU - Jänichen J FAU - Hallensleben, Nina AU - Hallensleben N FAU - Nickel, Witiko AU - Nickel W FAU - Hinz, Andreas AU - Hinz A FAU - Brähler, Elmar AU - Brähler E FAU - Gertz, Hermann-Josef AU - Gertz HJ LA - eng SI - ClinicalTrials.gov/NCT01690117 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140212 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 SB - IM MH - *Adaptation, Psychological MH - Alzheimer Disease/epidemiology/*psychology/*therapy MH - Caregivers/*psychology MH - Early Medical Intervention/*methods MH - Germany/epidemiology MH - Home Care Services/*standards MH - Humans PMC - PMC3925255 EDAT- 2014/02/14 06:00 MHDA- 2014/10/10 06:00 PMCR- 2014/02/12 CRDT- 2014/02/14 06:00 PHST- 2014/01/23 00:00 [received] PHST- 2014/02/10 00:00 [accepted] PHST- 2014/02/14 06:00 [entrez] PHST- 2014/02/14 06:00 [pubmed] PHST- 2014/10/10 06:00 [medline] PHST- 2014/02/12 00:00 [pmc-release] AID - 1471-2318-14-21 [pii] AID - 10.1186/1471-2318-14-21 [doi] PST - epublish SO - BMC Geriatr. 2014 Feb 12;14:21. doi: 10.1186/1471-2318-14-21. PMID- 24776983 OWN - NLM STAT- MEDLINE DCOM- 20150102 LR - 20240503 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 6 IP - 5 DP - 2014 Apr 25 TI - Staphylococcal enterotoxins in the etiopathogenesis of mucosal autoimmunity within the gastrointestinal tract. PG - 1471-89 LID - 10.3390/toxins6051471 [doi] AB - The staphylococcal enterotoxins (SEs) are the products of Staphylococcus aureus and are recognized as the causative agents of classical food poisoning in humans following the consumption of contaminated food. While illness evoked by ingestion of the SE or its producer organism in tainted food are often self-limited, our current understanding regarding the evolution of S. aureus provokes the utmost concern. The organism and its associated toxins, has been implicated in a wide variety of disease states including infections of the skin, heart, sinuses, inflammatory gastrointestinal disease, toxic shock, and Sudden Infant Death Syndrome. The intricate relationship between the various subsets of immunocompetent T cells and accessory cells and the ingested material found within the gastrointestinal tract present daunting challenges to the maintenance of immunologic homeostasis. Dysregulation of the intricate balances within this environment has the potential for extreme consequences within the host, some of which are long-lived. The focus of this review is to evaluate the relevance of staphylococcal enterotoxin in the context of mucosal immunity, and the underlying mechanisms that contribute to the pathogenesis of gastrointestinal autoimmune disease. FAU - Principato, MaryAnn AU - Principato M AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. maryann.principato@fda.hhs.gov. FAU - Qian, Bi-Feng AU - Qian BF AD - Commissioner's Fellowship Program, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA. bifeng.qian@fda.hhs.gov. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PT - Review DEP - 20140425 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 0 (Bacterial Toxins) RN - 0 (Enterotoxins) SB - IM MH - Bacterial Toxins/*toxicity MH - Enterotoxins/*toxicity MH - Gastrointestinal Tract/*drug effects/immunology MH - Humans MH - *Immunity, Mucosal MH - Intestinal Mucosa/*drug effects/immunology MH - Lymphoid Tissue/immunology MH - Staphylococcus aureus/*metabolism PMC - PMC4052247 EDAT- 2014/04/30 06:00 MHDA- 2015/01/03 06:00 PMCR- 2014/05/01 CRDT- 2014/04/30 06:00 PHST- 2013/12/18 00:00 [received] PHST- 2014/04/18 00:00 [revised] PHST- 2014/04/22 00:00 [accepted] PHST- 2014/04/30 06:00 [entrez] PHST- 2014/04/30 06:00 [pubmed] PHST- 2015/01/03 06:00 [medline] PHST- 2014/05/01 00:00 [pmc-release] AID - toxins6051471 [pii] AID - toxins-06-01471 [pii] AID - 10.3390/toxins6051471 [doi] PST - epublish SO - Toxins (Basel). 2014 Apr 25;6(5):1471-89. doi: 10.3390/toxins6051471. PMID- 32854203 OWN - NLM STAT- MEDLINE DCOM- 20201123 LR - 20201123 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 17 IP - 17 DP - 2020 Aug 25 TI - A Comprehensive Model for Estimating Heat Vulnerability of Young Athletes. LID - 10.3390/ijerph17176156 [doi] LID - 6156 AB - Current methods for estimating heat vulnerability of young athletes use a heat index (HI) or a wet bulb globe thermometer (WBGT), neither of which fully include the environmental or physiological characteristics that can affect a person's heat budget, particularly where activity occurs on a synthetic surface. This study analyzed and compared the standard methods, HI and WBGT, with a novel and more comprehensive method termed COMFA-Kid (CK) which is based on an energy budget model explicitly designed for youth. The COMFA model was presented at the same time to demonstrate the difference between a child and an adult during activity. Micrometeorological measurements were taken at a synthetic-surfaced football field during mid-day in hot environmental conditions. Standard methods (HI and WBGT) indicated that conditions on the field were relatively safe for youth to engage in activities related to football practice or games, whereas the CK method indicated that conditions were dangerously hot and could lead to exertional heat illness. Estimates using the CK method also indicated that coaches and staff standing on the sidelines, and parents sitting in the stands, would not only be safe from heat but would be thermally comfortable. The difference in thermal comfort experienced by coaches and staff off the field, versus that experienced by young players on the field, could affect decision making regarding the duration and intensity of practices and time in the game. The CK method, which is easy to use and available for modification for specific conditions, would lead to more accurate estimates of heat safety on outdoor synthetic surfaces in particular, and in sports with a high prevalence of heat illness such as football, and should be considered as a complementary or alternative preventive measure against heat. FAU - Cheng, Wenwen AU - Cheng W AUID- ORCID: 0000-0003-1160-0928 AD - College of Architecture, The University of Oklahoma, Norman, OK 73019, USA. FAU - Spengler, J O AU - Spengler JO AD - School of Public Health, Texas A&M University, College Station, TX 77843, USA. FAU - Brown, Robert D AU - Brown RD AUID- ORCID: 0000-0001-6955-910X AD - Department of Landscape Architecture and Urban Planning, Texas A&M University, College Station, TX 77843, USA. LA - eng PT - Journal Article DEP - 20200825 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Adult MH - Athletes/*psychology/statistics & numerical data MH - Child MH - Extreme Heat MH - *Football MH - Heat Stress Disorders/*prevention & control MH - Hot Temperature MH - Humans MH - *Soccer PMC - PMC7503897 OTO - NOTNLM OT - WBGT OT - ballfield design OT - energy budget thermal model OT - heat stress index OT - young athletes thermal health COIS- The authors declare no conflict of interest. EDAT- 2020/08/29 06:00 MHDA- 2020/11/24 06:00 PMCR- 2020/09/01 CRDT- 2020/08/29 06:00 PHST- 2020/06/24 00:00 [received] PHST- 2020/08/12 00:00 [revised] PHST- 2020/08/20 00:00 [accepted] PHST- 2020/08/29 06:00 [entrez] PHST- 2020/08/29 06:00 [pubmed] PHST- 2020/11/24 06:00 [medline] PHST- 2020/09/01 00:00 [pmc-release] AID - ijerph17176156 [pii] AID - ijerph-17-06156 [pii] AID - 10.3390/ijerph17176156 [doi] PST - epublish SO - Int J Environ Res Public Health. 2020 Aug 25;17(17):6156. doi: 10.3390/ijerph17176156. PMID- 16126026 OWN - NLM STAT- MEDLINE DCOM- 20051006 LR - 20181201 IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 96 IP - 5A DP - 2005 Sep 5 TI - Safety of high-dose atorvastatin therapy. PG - 69F-75F AB - This article reviews the safety of statins, with emphasis on high-dose atorvastatin (80 mg), the agent with the most efficacy data for clinical outcomes. Although elevated levels of hepatic enzymes were of concern when statins were first introduced, a review of data from large clinical trials shows that elevations in hepatic enzymes are rare and do not lead to clinically significant liver disease. Despite the withdrawal of cerivastatin because of fatal rhabdomyolysis, the risk of this complication with other statins is extremely low. Mild and often transient myalgia is more commonly reported. The safety of high-dose atorvastatin has been evaluated in >11,000 patients, and rates of clinically significant myopathy and elevated hepatic enzymes were extremely low. Simvastatin at doses up to 40 mg is also associated with low rates of elevated hepatic enzymes and myopathy. However, the 80-mg dose of simvastatin carries a risk of myopathy (muscle symptoms and creatine kinase levels >10,000 U/L) of approximately 1 in 250. The clinical benefits of preventing vascular events, myocardial infarction, stroke, and need for revascularization outweigh the low rates of adverse events associated with high-dose statin therapy in high- and intermediate-risk patients. FAU - Waters, David D AU - Waters DD AD - Division of Cardiology, San Francisco General Hospital and the School of Medicine, University of California, San Francisco, California 94110, USA. dwaters@medsfgh.ucsf.edu LA - eng PT - Journal Article PT - Review PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Heptanoic Acids) RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) RN - 0 (Pyrroles) RN - A0JWA85V8F (Atorvastatin) RN - AGG2FN16EV (Simvastatin) SB - IM MH - Atorvastatin MH - Drug Administration Schedule MH - Heptanoic Acids/administration & dosage/adverse effects/*therapeutic use MH - Humans MH - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/adverse effects/*therapeutic use MH - Myocardial Infarction/*prevention & control MH - Pyrroles/administration & dosage/adverse effects/*therapeutic use MH - Simvastatin/administration & dosage/adverse effects/*therapeutic use RF - 59 EDAT- 2005/08/30 09:00 MHDA- 2005/10/07 09:00 CRDT- 2005/08/30 09:00 PHST- 2005/08/30 09:00 [pubmed] PHST- 2005/10/07 09:00 [medline] PHST- 2005/08/30 09:00 [entrez] AID - S0002-9149(05)01086-6 [pii] AID - 10.1016/j.amjcard.2005.06.028 [doi] PST - ppublish SO - Am J Cardiol. 2005 Sep 5;96(5A):69F-75F. doi: 10.1016/j.amjcard.2005.06.028. PMID- 34303045 OWN - NLM STAT- MEDLINE DCOM- 20211110 LR - 20221207 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 286 IP - Pt 1 DP - 2022 Jan TI - The treatment of electroplating wastewater using an integrated approach of interior microelectrolysis and Fenton combined with recycle ferrite. PG - 131543 LID - S0045-6535(21)02015-4 [pii] LID - 10.1016/j.chemosphere.2021.131543 [doi] AB - Heavy metal ions in chelated forms have aroused great concerns because of their high solubility, poor biodegradation and extreme stability. In this research, an efficient strategy, interior microelectrolysis-Fenton-recycle ferrite (IM-Fenton-RF), was developed to treat simulated electroplating wastewater containing chelated copper at room temperature. The decomplexation of chelated copper was carried out by both interior microelectrolysis and Fenton reactions. IM process can not only partly degrade the complexes of chelated copper via the microelectrolysis reaction but also it produces Fe(2+) ions for the Fenton reaction. After decomplexation, the IM-Fenton effluent directly flowed into the RF reactor for copper ions removal. Under optimum reaction conditions (reflux ratio = 0.37, Fe(2+) concentration = 9.20 g/L at pH 10.18), 99.9% copper was removed by the IM-Fenton-RF system. The produced IM-Fenton-RF sludge is based on ferrite precipitate and has several advantages over metal hydroxides sludge. Ferrite sludge is stable owing to the stability of ferrite's crystal structure, while the toxicity characteristic leaching procedure (TCLP) test meets relevant standards. The sedimentation rate and volume of ferrite sludge were 3.86 times faster and 11.0 times lower than those of metal hydroxides sludge. Furthermore, the yielding sludge of ferrite can be recovered and utilized for the synthesis of Fe-C metallic species, the main compound of IM packing for interior microelectrolysis reaction. All these results show that a combination of IM-Fenton and RF is an effective approach to treat wastewater containing chelated copper, showing great potential for industrial applications. CI - Copyright © 2021 Elsevier Ltd. All rights reserved. FAU - Wang, Lei AU - Wang L AD - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China; School of Environmental Resources, AnQing Normal University, No.1318 Jixian North Road, Anqing, 246133, China. FAU - Luo, Zhijun AU - Luo Z AD - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China. Electronic address: lzj@ujs.edu.cn. FAU - Hong, Yongxiang AU - Hong Y AD - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China. FAU - Chelme-Ayala, Pamela AU - Chelme-Ayala P AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada. FAU - Meng, Lingjun AU - Meng L AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada. FAU - Wu, Zhiren AU - Wu Z AD - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China. FAU - Gamal El-Din, Mohamed AU - Gamal El-Din M AD - School of the Environment and Safety Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China; Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada. Electronic address: mgamalel-din@ualberta.ca. LA - eng PT - Journal Article DEP - 20210713 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Ferric Compounds) RN - 0 (Metals, Heavy) RN - 0 (Waste Water) RN - 1317-54-0 (ferrite) SB - IM MH - Electroplating MH - Ferric Compounds MH - *Metals, Heavy MH - *Wastewater OTO - NOTNLM OT - Copper complex OT - Recycle ferrite OT - Sludge reduction OT - TCLP EDAT- 2021/07/25 06:00 MHDA- 2021/11/11 06:00 CRDT- 2021/07/24 20:15 PHST- 2021/04/09 00:00 [received] PHST- 2021/06/17 00:00 [revised] PHST- 2021/07/10 00:00 [accepted] PHST- 2021/07/25 06:00 [pubmed] PHST- 2021/11/11 06:00 [medline] PHST- 2021/07/24 20:15 [entrez] AID - S0045-6535(21)02015-4 [pii] AID - 10.1016/j.chemosphere.2021.131543 [doi] PST - ppublish SO - Chemosphere. 2022 Jan;286(Pt 1):131543. doi: 10.1016/j.chemosphere.2021.131543. Epub 2021 Jul 13. PMID- 31310729 OWN - NLM STAT- MEDLINE DCOM- 20200106 LR - 20221207 IS - 1480-3275 (Electronic) IS - 0008-4166 (Linking) VI - 65 IP - 11 DP - 2019 Nov TI - Control of pathogens in fresh pork sausage by inclusion of Lactobacillus sakei BAS0117. PG - 831-841 LID - 10.1139/cjm-2019-0136 [doi] AB - A pork sausage was produced with low sodium content (1.64%) to which Lactobacillus sakei was added with the aim of developing a meat pork sausage for cooking and having technological, organoleptic, and hygienic advantages. The lactic acid bacteria (LAB) L. sakei, Lactococcus sp., and Pediococcus pentosaceus were submitted to extreme pH, temperature, and NaCl conditions. Lactobacillus sakei was used in pork sausage because of its resistance to different culture conditions and its antimicrobial potential. The food-borne pathogens Listeria monocytogenes Scott A, Enterococcus faecalis, and Staphylococcus aureus were used as indicator microorganisms to evaluate the antimicrobial activity of selected LAB strains. Salmonella enterica serotype Choleraesuis is a common pathogen of pigs. To the raw sausage product containing L. sakei and nonpathogenic endogenous microbiota, we added about >10(4) and <10(5) CFU/g of S. enterica serotype Choleraesuis to evaluate the inhibitory potential of L. sakei towards this pathogen. Salmonella Choleraesuis was inhibited in the presence of L. sakei over 7 days of storage of the meat product (about 3.0 log cycles reduction). Lactobacillus sakei significantly increased inhibition when compared with the nonfermented sausage. Thus, L. sakei BAS0117 played an important role as an additional hurdle in the fermented meat pork sausage during storage. FAU - Gelinski, Jane Mary Lafayette Neves AU - Gelinski JMLN AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - Baratto, César Milton AU - Baratto CM AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - Casagrande, Micheli AU - Casagrande M AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - de Oliveira, Tainara Padilha AU - de Oliveira TP AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - Megiolaro, Fernanda AU - Megiolaro F AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - de Martini Soares, Fabiana Andreia S AU - de Martini Soares FAS AD - University of West of Santa Catarina, Videira, Santa Catarina, Brazil. FAU - de Souza, Endler Marcel Borges AU - de Souza EMB AD - Foundation Regional University of Blumenau, Santa Catarina, Brazil. FAU - Vicente, Vânia Aparecida AU - Vicente VA AD - Federal University of Paraná, Curitiba, Paraná, Brazil. FAU - Fonseca, Gustavo Graciano AU - Fonseca GG AD - Federal University of Grande Dourados, Mato Grosso do Sol, Brazil. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20190716 PL - Canada TA - Can J Microbiol JT - Canadian journal of microbiology JID - 0372707 RN - 0 (Food Additives) SB - IM MH - Animals MH - Antibiosis MH - Colony Count, Microbial MH - Fermentation MH - Food Additives/analysis MH - Food Microbiology MH - Food Preservation/*methods MH - Latilactobacillus sakei/*physiology MH - Listeria monocytogenes/growth & development/physiology MH - Meat Products/*microbiology MH - Staphylococcus aureus/growth & development/physiology MH - Swine OTO - NOTNLM OT - barrière OT - food safety OT - hurdle technology OT - inhibition d’agents pathogènes OT - meat product OT - pathogen inhibition OT - produit de la viande OT - sécurité alimentaire EDAT- 2019/07/17 06:00 MHDA- 2020/01/07 06:00 CRDT- 2019/07/17 06:00 PHST- 2019/07/17 06:00 [pubmed] PHST- 2020/01/07 06:00 [medline] PHST- 2019/07/17 06:00 [entrez] AID - 10.1139/cjm-2019-0136 [doi] PST - ppublish SO - Can J Microbiol. 2019 Nov;65(11):831-841. doi: 10.1139/cjm-2019-0136. Epub 2019 Jul 16. PMID- 24535397 OWN - NLM STAT- MEDLINE DCOM- 20141006 LR - 20220318 IS - 1471-2970 (Electronic) IS - 0962-8436 (Print) IS - 0962-8436 (Linking) VI - 369 IP - 1639 DP - 2014 Apr 5 TI - Extreme vulnerability of smallholder farmers to agricultural risks and climate change in Madagascar. PG - 20130089 LID - 10.1098/rstb.2013.0089 [doi] LID - 20130089 AB - Across the tropics, smallholder farmers already face numerous risks to agricultural production. Climate change is expected to disproportionately affect smallholder farmers and make their livelihoods even more precarious; however, there is limited information on their overall vulnerability and adaptation needs. We conducted surveys of 600 households in Madagascar to characterize the vulnerability of smallholder farmers, identify how farmers cope with risks and explore what strategies are needed to help them adapt to climate change. Malagasy farmers are particularly vulnerable to any shocks to their agricultural system owing to their high dependence on agriculture for their livelihoods, chronic food insecurity, physical isolation and lack of access to formal safety nets. Farmers are frequently exposed to pest and disease outbreaks and extreme weather events (particularly cyclones), which cause significant crop and income losses and exacerbate food insecurity. Although farmers use a variety of risk-coping strategies, these are insufficient to prevent them from remaining food insecure. Few farmers have adjusted their farming strategies in response to climate change, owing to limited resources and capacity. Urgent technical, financial and institutional support is needed to improve the agricultural production and food security of Malagasy farmers and make their livelihoods resilient to climate change. FAU - Harvey, Celia A AU - Harvey CA AD - Conservation International, , 2011 Crystal Drive Suite 500, Arlington, VA 22202, USA. FAU - Rakotobe, Zo Lalaina AU - Rakotobe ZL FAU - Rao, Nalini S AU - Rao NS FAU - Dave, Radhika AU - Dave R FAU - Razafimahatratra, Hery AU - Razafimahatratra H FAU - Rabarijohn, Rivo Hasinandrianina AU - Rabarijohn RH FAU - Rajaofara, Haingo AU - Rajaofara H FAU - Mackinnon, James L AU - Mackinnon JL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140217 PL - England TA - Philos Trans R Soc Lond B Biol Sci JT - Philosophical transactions of the Royal Society of London. Series B, Biological sciences JID - 7503623 SB - IM MH - Agriculture/*economics/methods/*trends MH - Climate Change/*economics MH - Focus Groups MH - Food Supply/*statistics & numerical data MH - Humans MH - Interviews as Topic MH - Madagascar MH - Rural Population MH - Seasons MH - Socioeconomic Factors PMC - PMC3928894 OTO - NOTNLM OT - Madagascar OT - adaptation OT - agriculture OT - climate change OT - food security OT - livelihoods EDAT- 2014/02/19 06:00 MHDA- 2014/10/07 06:00 PMCR- 2014/04/05 CRDT- 2014/02/19 06:00 PHST- 2014/02/19 06:00 [entrez] PHST- 2014/02/19 06:00 [pubmed] PHST- 2014/10/07 06:00 [medline] PHST- 2014/04/05 00:00 [pmc-release] AID - rstb.2013.0089 [pii] AID - rstb20130089 [pii] AID - 10.1098/rstb.2013.0089 [doi] PST - epublish SO - Philos Trans R Soc Lond B Biol Sci. 2014 Feb 17;369(1639):20130089. doi: 10.1098/rstb.2013.0089. Print 2014 Apr 5. PMID- 18381525 OWN - NLM STAT- MEDLINE DCOM- 20080430 LR - 20080402 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 121 IP - 4 DP - 2008 Apr TI - Use of aromatase inhibitors in children and adolescents with disorders of growth and adolescent development. PG - e975-83 LID - 10.1542/peds.2007-2081 [doi] AB - Although treatment of children and adolescents who have disorders of growth and adolescent development with aromatase inhibitors is increasingly common, data for or against their use are extremely limited. Precocious puberty, short stature, and gynecomastia are conditions for which inhibition of the enzyme aromatase might prove beneficial to reduce clinical signs of estrogenization and/or estrogen-mediated skeletal maturation. In this report, we summarize the published data regarding the use of aromatase inhibitors in these conditions, and review known and potential benefits, safety concerns, and shortcomings of the available information. FAU - Shulman, Dorothy I AU - Shulman DI AD - All Children's Hospital, St Petersburg, Florida 33701, USA. dshulman@health.usf.edu FAU - Francis, Gary L AU - Francis GL FAU - Palmert, Mark R AU - Palmert MR FAU - Eugster, Erica A AU - Eugster EA CN - Lawson Wilkins Pediatric Endocrine Society Drug and Therapeutics Committee LA - eng PT - Journal Article PT - Review PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 RN - 0 (Aromatase Inhibitors) SB - IM MH - Adolescent MH - Age Factors MH - Aromatase Inhibitors/*therapeutic use MH - Body Height/drug effects MH - Bone Density/drug effects MH - Bone Development/drug effects/physiology MH - Child MH - Child Development/drug effects/physiology MH - Child, Preschool MH - Female MH - Growth Disorders/diagnosis/*drug therapy MH - Gynecomastia/*drug therapy MH - Humans MH - Male MH - Prognosis MH - Puberty, Precocious/*drug therapy MH - Risk Assessment MH - Sensitivity and Specificity MH - Sex Factors MH - Sexual Maturation/drug effects/physiology RF - 73 FIR - Misra, Madhusmita IR - Misra M FIR - Pacaud, Daniele IR - Pacaud D FIR - Petryk, Anna IR - Petryk A FIR - Solberg, Paulo IR - Solberg P FIR - Speiser, Phyllis IR - Speiser P FIR - Rogol, Alan IR - Rogol A EDAT- 2008/04/03 09:00 MHDA- 2008/05/01 09:00 CRDT- 2008/04/03 09:00 PHST- 2008/04/03 09:00 [pubmed] PHST- 2008/05/01 09:00 [medline] PHST- 2008/04/03 09:00 [entrez] AID - 121/4/e975 [pii] AID - 10.1542/peds.2007-2081 [doi] PST - ppublish SO - Pediatrics. 2008 Apr;121(4):e975-83. doi: 10.1542/peds.2007-2081. PMID- 38395291 OWN - NLM STAT- MEDLINE DCOM- 20240327 LR - 20240327 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 263 IP - Pt 2 DP - 2024 Apr TI - Construction of catalase@hollow silica nanosphere: Catalase with immobilized but not rigid state for improving catalytic performances. PG - 130381 LID - S0141-8130(24)01184-X [pii] LID - 10.1016/j.ijbiomac.2024.130381 [doi] AB - Enzyme immobilization usually make use of nanomaterials to hold up biocatalysis stability in various unamiable reaction conditions, but also lead large discount on enzyme activity. Thus, there are abundant researches focus on how to deal with the relation of enzyme molecules and supports. In this work, a new state of highly active enzymes has been established through facile and novel in situ immobilization and soft template removal method to construct enzyme contained hollow silica nanosphere (catalase@HSN) biocatalysts where enzymes in the cavity exhibit "immobilized but not rigid state". The obtained catalase@HSN was characterized by transmission electron microscopy, scanning electron microscopy and confocal laser scanning microscopy et al. Catalase@HSN exhibits excellent activity (about 80 % activity recovery rate) and stability suffers from extreme pH, temperature, and organic solvents. Moreover, the reusability and storage stability of catalase@HSN also are satisfactory. This proposed strategy provides a facile method for preparing biocatalysts under mild conditions, facilitating the applications of immobilized enzyme in the fields of real biocatalytic industry with high apparent activity and passable stability. CI - Copyright © 2024 Elsevier B.V. All rights reserved. FAU - Du, Yingjie AU - Du Y AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China; State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, China; Tianjin UBasio Biotechnology Group, China. FAU - Zhao, Lixue AU - Zhao L AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. FAU - Geng, Zixin AU - Geng Z AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. FAU - Huo, Zibei AU - Huo Z AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. FAU - Li, Huihui AU - Li H AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. FAU - Shen, Xuejian AU - Shen X AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. FAU - Peng, Xiaogang AU - Peng X AD - State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, China. FAU - Yan, Renyi AU - Yan R AD - Tianjin UBasio Biotechnology Group, China. FAU - Cui, Jiandong AU - Cui J AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. Electronic address: jdcui@tust.edu.cn. FAU - Jia, Shiru AU - Jia S AD - State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, State Key Laboratory of Biobased Fiber Manufacturing Technology, Tianjin University of Science and Technology, China. LA - eng PT - Journal Article DEP - 20240221 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - EC 1.11.1.6 (Catalase) RN - 7631-86-9 (Silicon Dioxide) RN - 0 (Enzymes, Immobilized) SB - IM MH - Catalase/metabolism MH - *Silicon Dioxide/chemistry MH - *Nanospheres/chemistry MH - Enzymes, Immobilized/chemistry MH - Biocatalysis MH - Enzyme Stability OTO - NOTNLM OT - Biocatalysts OT - Hollow silica OT - Immobilized catalase OT - Nanomaterials OT - Soft template COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2024/02/24 11:42 MHDA- 2024/03/27 06:44 CRDT- 2024/02/23 19:17 PHST- 2023/11/25 00:00 [received] PHST- 2024/02/19 00:00 [revised] PHST- 2024/02/20 00:00 [accepted] PHST- 2024/03/27 06:44 [medline] PHST- 2024/02/24 11:42 [pubmed] PHST- 2024/02/23 19:17 [entrez] AID - S0141-8130(24)01184-X [pii] AID - 10.1016/j.ijbiomac.2024.130381 [doi] PST - ppublish SO - Int J Biol Macromol. 2024 Apr;263(Pt 2):130381. doi: 10.1016/j.ijbiomac.2024.130381. Epub 2024 Feb 21. PMID- 34102130 OWN - NLM STAT- MEDLINE DCOM- 20211125 LR - 20211125 IS - 2667-2960 (Electronic) IS - 2667-2960 (Linking) VI - 62 IP - 3 DP - 2021 May-Jun TI - The Use of Physostigmine in the Diagnosis and Treatment of Anticholinergic Toxicity After Olanzapine Overdose: Literature Review and Case Report. PG - 285-297 LID - S2667-2960(21)00001-X [pii] LID - 10.1016/j.jaclp.2020.12.013 [doi] AB - BACKGROUND: Second-generation antipsychotic agents are commonly used by clinicians for the treatment of various psychiatric and medical conditions. Despite their presumed safety, an overdose with olanzapine may lead to the development of anticholinergic toxicity. The anticholinergic toxidrome is characterized by both central and peripheral physical findings. Central anticholinergic syndrome, a term used to describe the symptoms that arise from reduced cholinergic activity in the central nervous system, is characterized primarily by signs and symptoms consistent with hyperactive delirium. Signs of peripheral anticholinergia include mydriasis and blurred vision, tremors, ataxia, fever/hyperthermia, flushed and dry skin, dry oral mucosa, decreased bowel sounds, constipation, and urinary retention, among other symptoms. In extreme cases, central anticholinergic syndrome can be associated with seizures, coma, respiratory failure, and cardiovascular collapse. OBJECTIVE: To provide scientific evidence regarding the efficacy and safety of physostigmine use in cases of anticholinergic toxicity. METHODS: We conducted a comprehensive review of the published literature on the symptoms, diagnosis, and treatment of anticholinergic toxicity. RESULTS: Currently the recommended treatment for olanzapine overdose, as is the case of most severe anticholinergic toxicity cases, involves supportive care, along with cardiac, neurological, and respiratory status monitoring. In addition, we detail the symptoms characteristic of anticholinergic toxicity, using the case of a patient experiencing central anticholinergic syndrome after an overdose with olanzapine. CONCLUSION: Physostigmine, a tertiary acetylcholinesterase inhibitor, can be used to assist in the both the diagnosis and management of severe anticholinergic toxicity associated with an olanzapine overdose, which might be applicable to the antimuscarinic toxidrome associated with the ingestion of agents with significant anticholinergic activity. CI - Copyright © 2021 Academy of Consultation-Liaison Psychiatry. Published by Elsevier Inc. All rights reserved. FAU - Serrano, Wilmarie Cidre AU - Serrano WC AD - Department of Psychiatry & Behavioral Sciences, Stanford University 401 Quarry Road, Stanford, CA. FAU - Maldonado, Jose AU - Maldonado J AD - Department of Psychiatry & Behavioral Sciences, Stanford University 401 Quarry Road, Stanford, CA. Electronic address: jrm@stanford.edu. LA - eng PT - Case Reports PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20210114 PL - Netherlands TA - J Acad Consult Liaison Psychiatry JT - Journal of the Academy of Consultation-Liaison Psychiatry JID - 101775059 RN - 0 (Cholinergic Antagonists) RN - 9U1VM840SP (Physostigmine) RN - EC 3.1.1.7 (Acetylcholinesterase) RN - N7U69T4SZR (Olanzapine) SB - IM MH - Acetylcholinesterase MH - *Anticholinergic Syndrome/diagnosis MH - Cholinergic Antagonists MH - Humans MH - Olanzapine MH - *Physostigmine/therapeutic use OTO - NOTNLM OT - anticholinergic toxicity OT - antimuscarinic toxidrome OT - consultation liaison psychiatry OT - delirium OT - olanzapine overdose OT - psychopharmacology EDAT- 2021/06/09 06:00 MHDA- 2021/11/26 06:00 CRDT- 2021/06/08 20:16 PHST- 2020/11/13 00:00 [received] PHST- 2020/12/24 00:00 [revised] PHST- 2020/12/27 00:00 [accepted] PHST- 2021/06/08 20:16 [entrez] PHST- 2021/06/09 06:00 [pubmed] PHST- 2021/11/26 06:00 [medline] AID - S2667-2960(21)00001-X [pii] AID - 10.1016/j.jaclp.2020.12.013 [doi] PST - ppublish SO - J Acad Consult Liaison Psychiatry. 2021 May-Jun;62(3):285-297. doi: 10.1016/j.jaclp.2020.12.013. Epub 2021 Jan 14. PMID- 24986933 OWN - NLM STAT- MEDLINE DCOM- 20150915 LR - 20161020 IS - 1526-3347 (Electronic) IS - 0191-9601 (Linking) VI - 35 IP - 7 DP - 2014 Jul TI - Closing the global immunization gap: delivery of lifesaving vaccines through innovation and technology. PG - e32-40 LID - 10.1542/pir.35-7-e32 [doi] AB - One of every 5 children does not receive basic vaccines because of concerns related to storage and delivery in resource limited countries. Transporting vaccines over long distances in extreme temperatures is a common challenge. Issues that involve production and formulation, delivery technologies, cold chain logistics, and safety factors need to be addressed to properly adapt vaccines to resource constrained settings. Current successful field interventions include United Nation Children's Fund cold boxes, which are used to store and distribute vaccine in disaster struck areas, and vaccine vial monitors, which allow health workers to gauge whether vaccine is still usable in areas with unreliable electricity and refrigeration. This review aims to provide a general overview of innovative approaches and technologies that positively affect vaccine coverage and save more lives. CI - © American Academy of Pediatrics, 2014. All rights reserved. FAU - Desai, Sachin N AU - Desai SN AD - International Vaccine Institute, Seoul, South Korea. FAU - Kamat, Deepak AU - Kamat D AD - Department of Pediatrics, Wayne State University, and Children's Hospital of Michigan, Detroit, MI. LA - eng PT - Journal Article PT - Review PL - United States TA - Pediatr Rev JT - Pediatrics in review JID - 8103046 RN - 0 (Vaccines) SB - IM MH - Biomedical Technology MH - Child Welfare MH - Child, Preschool MH - Communicable Disease Control/*organization & administration MH - Female MH - *Global Health MH - Health Services Accessibility/organization & administration MH - Humans MH - Immunization Programs/*organization & administration MH - Infant MH - Male MH - Needs Assessment MH - Organizational Innovation MH - Vaccines/*administration & dosage/pharmacology EDAT- 2014/07/06 06:00 MHDA- 2015/09/16 06:00 CRDT- 2014/07/03 06:00 PHST- 2014/07/03 06:00 [entrez] PHST- 2014/07/06 06:00 [pubmed] PHST- 2015/09/16 06:00 [medline] AID - 35/7/e32 [pii] AID - 10.1542/pir.35-7-e32 [doi] PST - ppublish SO - Pediatr Rev. 2014 Jul;35(7):e32-40. doi: 10.1542/pir.35-7-e32. PMID- 10148973 OWN - NLM STAT- MEDLINE DCOM- 19920528 LR - 20101118 IS - 1042-3931 (Print) IS - 1042-3931 (Linking) VI - 2 IP - 4 DP - 1990 Jul-Aug TI - Probe III catheter, an improved balloon-on-a-wire system: initial experience. Probe III Investigators Group. PG - 139-45 AB - Over the last several years, extremely low-profile balloon-on-a-wire catheters have extended the limits of coronary angioplasty. However, the first such fixed-wire catheter, the Probe, experienced a number of mechanical failures, causing the manufacturer to reconfigure the catheter as the Probe III. The current study was therefore undertaken to assess the safety and efficacy of this new device in a variety of cases. The Probe III catheter was used as a primary dilatation device in 157 lesions in 113 patients over a three and one-half month period. One-hundred-six (93%) of the procedures were successful. There were no mechanical failures. The low profile and enhanced trackability of the Probe III catheter led to a high rate of procedural success in a variety of lesions, including extremely tight lesions, distal stenoses, bifurcation lesions, and bend-point lesions. The low profile and enhanced trackability also enabled excellent visualization, as well as quick and successful angioplasty in most patients. FAU - Shawl, F A AU - Shawl FA AD - Washington Adventist Hospital, Takoma Park, MD 20912. LA - eng PT - Journal Article PL - United States TA - J Invasive Cardiol JT - The Journal of invasive cardiology JID - 8917477 MH - Adult MH - Aged MH - Angioplasty, Balloon, Coronary/adverse effects/*instrumentation MH - Catheterization/*instrumentation MH - Coronary Artery Disease/*therapy MH - Equipment Design MH - Evaluation Studies as Topic MH - Female MH - Humans MH - Male MH - Middle Aged MH - Retrospective Studies EDAT- 1990/06/08 00:00 MHDA- 1990/06/08 00:01 CRDT- 1990/06/08 00:00 PHST- 1990/06/08 00:00 [pubmed] PHST- 1990/06/08 00:01 [medline] PHST- 1990/06/08 00:00 [entrez] PST - ppublish SO - J Invasive Cardiol. 1990 Jul-Aug;2(4):139-45. PMID- 29046094 OWN - NLM STAT- MEDLINE DCOM- 20180314 LR - 20190301 IS - 1478-7083 (Electronic) IS - 0035-8843 (Print) IS - 0035-8843 (Linking) VI - 100 IP - 3 DP - 2018 Mar TI - Ostomy creation with fewer sutures using tissue adhesives (cyanoacrylates) in inflammatory bowel disease: a pilot study. PG - 190-193 LID - 10.1308/rcsann.2017.0186 [doi] AB - Introduction Fistula formation around the ostomy site is a stoma-related complication often requiring surgical intervention. This complication may be caused by sutures or may develop as a complication of inflammatory bowel disease. Before conducting a clinical trial, we set out to investigate the safety of ostomy creation with fewer sutures using tissue adhesives in this pilot study. Methods Patients with inflammatory bowel disease who required surgery with ostomy creation at the Hyogo College of Medicine between January 2014 and December 2015 were enrolled. Safety was assessed by evaluating the incidence of stoma-related complications. Ostomy was restricted to loop ileostomy and was created with two sutures and tissue adhesives. Results A total of 14 patients were enrolled. Mean body mass index was 18.9 ± 2.0 kg/m(2). There were no cases of ostomy retraction and no severe adverse events were observed. Conclusions This pilot study demonstrates that ostomy creation using tissue adhesives is safe. Although retraction and adverse events were not observed, even in patients with inflammatory bowel disease who generally exhibit delayed wound healing, the body mass index was extremely low in this series. This study does not strongly recommend ostomy creation with tissue adhesives; further studies are needed to clarify the efficacy and safety of the procedure. FAU - Uchino, M AU - Uchino M AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Ikeuchi, H AU - Ikeuchi H AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Bando, T AU - Bando T AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Sasaki, H AU - Sasaki H AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Chohno, T AU - Chohno T AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Horio, Y AU - Horio Y AD - Department of Inflammatory Bowel Disease, Hyogo College of Medicine , Hyogo , Japan. FAU - Takesue, Y AU - Takesue Y AD - Division of Infection Control and Prevention, Hyogo College of Medicine , Hyogo , Japan. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20171019 PL - England TA - Ann R Coll Surg Engl JT - Annals of the Royal College of Surgeons of England JID - 7506860 RN - 0 (Cyanoacrylates) RN - 0 (Tissue Adhesives) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Cyanoacrylates MH - Female MH - Humans MH - Ileostomy/adverse effects/*methods MH - Inflammatory Bowel Diseases/*surgery MH - Male MH - Middle Aged MH - Pilot Projects MH - Postoperative Complications/epidemiology/prevention & control MH - Sutures MH - *Tissue Adhesives MH - Treatment Outcome MH - *Wound Closure Techniques/instrumentation MH - Young Adult PMC - PMC5930087 OTO - NOTNLM OT - Inflammatory bowel disease OT - Ostomy OT - Tissue adhesives EDAT- 2017/10/20 06:00 MHDA- 2018/03/15 06:00 PMCR- 2019/03/01 CRDT- 2017/10/20 06:00 PHST- 2017/10/20 06:00 [pubmed] PHST- 2018/03/15 06:00 [medline] PHST- 2017/10/20 06:00 [entrez] PHST- 2019/03/01 00:00 [pmc-release] AID - 2017.0186 [pii] AID - 10.1308/rcsann.2017.0186 [doi] PST - ppublish SO - Ann R Coll Surg Engl. 2018 Mar;100(3):190-193. doi: 10.1308/rcsann.2017.0186. Epub 2017 Oct 19. PMID- 31031873 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250130 IS - 1933-6586 (Print) IS - 1933-6594 (Electronic) IS - 1933-6586 (Linking) VI - 31 IP - 2 DP - 2019 Apr 1 TI - A Scoping Review of Acupuncture as a Potential Intervention for Neonatal Abstinence Syndrome. PG - 69-84 LID - 10.1089/acu.2018.1323 [doi] AB - Objective: Neonatal abstinence syndrome (NAS) has risen drastically over the past decade. Infants with NAS experience extreme discomfort and developmental delays when going into withdrawal. Management includes multiple supportive and nonpharmacologic therapies as first-line treatments in an effort to reduce or prevent the need for medication management. Acupuncture has demonstrated efficacy in adults experiencing withdrawal from addictions, as well as for treating many other conditions in pediatric patients who have similar symptoms to withdrawal. The purpose of this review is to evaluate the safety and efficacy of acupuncture for neonates in withdrawal. Materials and Methods: This review was guided by the Arksey and O'Malley methodological framework, and analysis was performed based on a social ecological model. The PRISMA [Preferred Reporting Items for Systematic Reviews and Meta-Analyses] statement was used to organize selected publications, and a flow chart was created to display the search process. PubMed, EMBASE, Cumulative Index to Nursing and Allied Health Literature, and the Cochrane Databases were searched for relevant publications. Results: Acupuncture appears to be safe and effective for reducing withdrawal symptoms in infants, and, thus, should be considered as an additional nonpharmacologic treatment option for NAS. FAU - Jackson, Heather J AU - Jackson HJ AD - Department of Anesthesiology and Office of Advanced Practice, Vanderbilt University Medical Center, Nashville, TN. FAU - Lopez, Cristina AU - Lopez C AD - College of Nursing, Medical University of South Carolina, Charleston, SC. FAU - Miller, Sarah AU - Miller S AD - College of Nursing, Medical University of South Carolina, Charleston, SC. FAU - Engelhardt, Barbara AU - Engelhardt B AD - Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN. LA - eng PT - Journal Article PT - Scoping Review DEP - 20190419 PL - United States TA - Med Acupunct JT - Medical acupuncture JID - 100899009 PMC - PMC6484350 OTO - NOTNLM OT - infant acupressure OT - infant acupuncture OT - neonatal abstinence syndrome OT - neonatal acupuncture OT - nonpharmacologic treatments OT - opioid withdrawal COIS- No competing financial interests exists. EDAT- 2019/04/30 06:00 MHDA- 2019/04/30 06:01 PMCR- 2019/04/19 CRDT- 2019/04/30 06:00 PHST- 2019/04/30 06:00 [entrez] PHST- 2019/04/30 06:00 [pubmed] PHST- 2019/04/30 06:01 [medline] PHST- 2019/04/19 00:00 [pmc-release] AID - 10.1089/acu.2018.1323 [pii] AID - 10.1089/acu.2018.1323 [doi] PST - ppublish SO - Med Acupunct. 2019 Apr 1;31(2):69-84. doi: 10.1089/acu.2018.1323. Epub 2019 Apr 19. PMID- 39007447 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240724 IS - 1530-6992 (Electronic) IS - 1530-6984 (Linking) VI - 24 IP - 29 DP - 2024 Jul 24 TI - "Peapod-like" Fiber Network: A Universal Strategy for Composite Solid Electrolytes to Inhibit Lithium Dendrite Growth in Solid-State Lithium Metal Batteries. PG - 9050-9057 LID - 10.1021/acs.nanolett.4c02274 [doi] AB - Solid-state lithium metal batteries (SSLMBs) are a promising energy storage technology, but challenges persist including electrolyte thickness and lithium (Li) dendrite puncture. A novel three-dimensional "peapod-like" composite solid electrolyte (CSEs) with low thickness (26.8 μm), high mechanical strength, and dendrite inhibition was designed. Incorporating Li(7)La(3)Zr(2)O(12) (LLZO) enhances both mechanical strength and ionic conductivity, stabilizing the CSE/Li interface and enabling Li symmetric batteries to stabilize for 3000 h. With structural advantages, the assembled LFP||Li and NCM811||Li cells exhibit excellent cycling performance. In addition, the constructed NCM811 pouch cell achieves a high gravimetric/volumetric energy density of 307.0 Wh kg(-1)/677.7 Wh L(-1), which can light up LEDs under extreme conditions, demonstrating practicality and high safety. This work offers a generalized strategy for CSE design and insights into high-performance SSLMBs. FAU - Fan, Wanqing AU - Fan W AD - School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China. FAU - Gou, Jingren AU - Gou J AD - Beijing Key Laboratory for Membrane Materials and Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. FAU - Huang, Ying AU - Huang Y AUID- ORCID: 0000-0001-5677-8426 AD - School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China. FAU - She, Kaihang AU - She K AD - School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China. FAU - Yu, Meng AU - Yu M AD - School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an 710072, China. FAU - Zhang, Zheng AU - Zhang Z AUID- ORCID: 0000-0001-6216-6872 AD - Beijing Key Laboratory for Membrane Materials and Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China. LA - eng PT - Journal Article DEP - 20240715 PL - United States TA - Nano Lett JT - Nano letters JID - 101088070 SB - IM OTO - NOTNLM OT - Li plating/stripping OT - Solid-state lithium metal batteries OT - composite solid electrolyte OT - pouch cell EDAT- 2024/07/15 12:42 MHDA- 2024/07/15 12:43 CRDT- 2024/07/15 07:43 PHST- 2024/07/15 12:43 [medline] PHST- 2024/07/15 12:42 [pubmed] PHST- 2024/07/15 07:43 [entrez] AID - 10.1021/acs.nanolett.4c02274 [doi] PST - ppublish SO - Nano Lett. 2024 Jul 24;24(29):9050-9057. doi: 10.1021/acs.nanolett.4c02274. Epub 2024 Jul 15. PMID- 38070216 OWN - NLM STAT- MEDLINE DCOM- 20240115 LR - 20240327 IS - 1873-7757 (Electronic) IS - 0145-2134 (Linking) VI - 147 DP - 2024 Jan TI - Conceptualising and challenging child neglect in humanitarian action: Protecting displaced children in Jordan and Palestine. PG - 106539 LID - S0145-2134(23)00527-6 [pii] LID - 10.1016/j.chiabu.2023.106539 [doi] AB - BACKGROUND: Humanitarian organisations commonly identify neglect as a specific form of harm from which children should be protected. However, lack of debate about the aetiology of child neglect has left intact a tendency to assume that it is due to a failure of caregivers. Obscured by this assumption are the role of the humanitarian system in supporting or, indeed, undermining the efforts of primary caregivers. OBJECTIVE: To bring together insights from the literature on child neglect in humanitarian settings with findings from empirical research in the Middle East. PARTICIPANTS AND SETTING: Fieldwork involved 38 'peer researchers' from five refugee communities: Sudanese, Somali, Iraqi, Syrian (in Jordan) and Palestinian (in Gaza). These researchers undertook enquiry with a total of around 300 people across their respective communities. METHODS: RESULTS: Fieldwork revealed neglect in three distinct areas: educational participation, access to healthcare, and physical safety. This neglect can be related to the humanitarian system, (including humanitarian agencies, host government, donors, etc.), that is both directly neglectful and undermining of caregivers' efforts. CONCLUSION: Caregivers in our study illustrated the impossibility of exercising constant vigilance over children within conditions of extreme social and economic marginalisation. Thoroughgoing debate about child neglect is needed to address this situation and ensure that caregivers receive adequate support to meet their children's needs. Such support should be offered in a manner that upholds the dignity of displaced people - adults and children alike. CI - Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Procter, Caitlin AU - Procter C AD - University of Bath, Centre for Development Studies, United Kingdom. FAU - Pontalti, Kirsten AU - Pontalti K AD - University of Bath, Centre for Development Studies, United Kingdom. FAU - Hart, Jason AU - Hart J AD - University of Bath, Centre for Development Studies, United Kingdom. Electronic address: jh462@bath.ac.uk. FAU - Alruzzi, Mohammed AU - Alruzzi M AD - University of Bath, Centre for Development Studies, United Kingdom. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20231208 PL - England TA - Child Abuse Negl JT - Child abuse & neglect JID - 7801702 SB - IM MH - Adult MH - Child MH - Humans MH - Jordan MH - Arabs MH - Middle East MH - *Child Abuse/prevention & control MH - Delivery of Health Care MH - *Refugees OTO - NOTNLM OT - Child neglect OT - Humanitarianism OT - Middle East OT - Protection OT - Refugees EDAT- 2023/12/10 06:42 MHDA- 2024/01/15 12:42 CRDT- 2023/12/09 18:01 PHST- 2023/07/19 00:00 [received] PHST- 2023/11/02 00:00 [revised] PHST- 2023/11/05 00:00 [accepted] PHST- 2024/01/15 12:42 [medline] PHST- 2023/12/10 06:42 [pubmed] PHST- 2023/12/09 18:01 [entrez] AID - S0145-2134(23)00527-6 [pii] AID - 10.1016/j.chiabu.2023.106539 [doi] PST - ppublish SO - Child Abuse Negl. 2024 Jan;147:106539. doi: 10.1016/j.chiabu.2023.106539. Epub 2023 Dec 8. PMID- 35590916 OWN - NLM STAT- MEDLINE DCOM- 20220523 LR - 20230907 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 22 IP - 9 DP - 2022 Apr 22 TI - Ground Control System for UAS Safe Landing Area Determination (SLAD) in Urban Air Mobility Operations. LID - 10.3390/s22093226 [doi] LID - 3226 AB - The use of the Unmanned Aerial Vehicles (UAV) and Unmanned Aircraft System (UAS) for civil, scientific, and military operations, is constantly increasing, particularly in environments very dangerous or impossible for human actions. Many tasks are currently carried out in metropolitan areas, such as urban traffic monitoring, pollution and land monitoring, security surveillance, delivery of small packages, etc. Estimation of features around the flight path and surveillance of crowded areas, where there is a high number of vehicles and/or obstacles, are of extreme importance for typical UAS missions. Ensuring safety and efficiency during air traffic operations in a metropolitan area is one of the conditions for Urban Air Mobility (UAM) operations. This paper focuses on the development of a ground control system capable of monitoring crowded areas or impervious sites, identifying the UAV position and a safety area for vertical landing or take-off maneuvers (VTOL), ensuring a high level of accuracy and robustness, even without using GNSS-derived navigation information, and with on-board terrain hazard detection and avoidance (DAA) capabilities, in particular during operations conducted in BVLOS (Beyond Visual Line Of Sight). The system is composed by a mechanically rotating real-time LiDAR (Light Detection and Ranging) sensor, linked to a Raspberry Pi 3 as SBC (Session Board Controller), and interfaced to a GCS (Ground Control Station) by wireless connection for data management and 3-D information transfer. FAU - Ariante, Gennaro AU - Ariante G AUID- ORCID: 0000-0002-7581-8224 AD - Department of Science and Technology, University of Naples "Parthenope", 80133 Naples, Italy. FAU - Ponte, Salvatore AU - Ponte S AUID- ORCID: 0000-0002-6162-9182 AD - Department of Engineering, University of Campania "L. Vanvitelli", 81031 Aversa, Italy. FAU - Papa, Umberto AU - Papa U AUID- ORCID: 0000-0003-3467-8218 AD - Department of Science and Technology, University of Naples "Parthenope", 80133 Naples, Italy. FAU - Greco, Alberto AU - Greco A AD - Department of Science and Technology, University of Naples "Parthenope", 80133 Naples, Italy. FAU - Del Core, Giuseppe AU - Del Core G AD - Department of Science and Technology, University of Naples "Parthenope", 80133 Naples, Italy. LA - eng PT - Journal Article DEP - 20220422 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Aircraft MH - Data Collection MH - Humans MH - Unmanned Aerial Devices PMC - PMC9104420 OTO - NOTNLM OT - LiDAR OT - UAS OT - UAV OT - obstacle detection and avoidance OT - safe landing area determination OT - urban air mobility COIS- The authors declare no conflict of interest. EDAT- 2022/05/21 06:00 MHDA- 2022/05/24 06:00 PMCR- 2022/04/22 CRDT- 2022/05/20 01:09 PHST- 2022/02/11 00:00 [received] PHST- 2022/04/15 00:00 [revised] PHST- 2022/04/20 00:00 [accepted] PHST- 2022/05/20 01:09 [entrez] PHST- 2022/05/21 06:00 [pubmed] PHST- 2022/05/24 06:00 [medline] PHST- 2022/04/22 00:00 [pmc-release] AID - s22093226 [pii] AID - sensors-22-03226 [pii] AID - 10.3390/s22093226 [doi] PST - epublish SO - Sensors (Basel). 2022 Apr 22;22(9):3226. doi: 10.3390/s22093226. PMID- 26868165 OWN - NLM STAT- MEDLINE DCOM- 20160802 LR - 20160321 IS - 1532-2157 (Electronic) IS - 0748-7983 (Linking) VI - 42 IP - 4 DP - 2016 Apr TI - Huge pseudomyxoma peritonei: Surgical strategies and procedures to employ to optimize the rate of complete cytoreductive surgery. PG - 552-7 LID - S0748-7983(16)00057-3 [pii] LID - 10.1016/j.ejso.2016.01.015 [doi] AB - BACKGROUND: Complete cytoreductive surgery (CCRS) plus Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is the best-known treatment for pseudomyxoma peritonei (PMP). In 30% of the cases, PMP realize a widespread involvement of the peritoneal cavity. In these extreme situations, we developed, devoted strategies to optimize the feasibility and safety of CCRS. This study describes the surgical resections required for CCRS and the consequent approaches that we propose to achieve CCRS. MATERIALS AND METHODS: We defined "huge PMP" by a peritoneal cancer index (PCI) ≥ 28. Surgical procedures of patients operated on between 1994 and 2014 were retrospectively reviewed from a prospective database in a single institution. RESULTS: During this period, 311 patients were operated on and 247 (79%) underwent CCRS + HIPEC. Among them, 100 patients presented "huge" PMP and 54 patients underwent CCRS + HIPEC. In patients with "huge" PMP, the rate of CCRS + HIPEC was 25% before 2002 and reached 71% between 2011 and 2014. We identified 3 conditions for CCRS 1) to guaranty a sufficient length of residual small bowel 2) to preserve the left gastric vessels in order to preserve the superior third of the stomach 3) to ensure that the hepatic pedicle can be entirely cleared from its tumor involvement. None of the other peritonectomy procedures were decisional for CCRS. CONCLUSION: Our learning curve improved the selection and completion rate of CCRS + HIPEC for "huge PMP". Some anatomical and physiological prerequisites guarantee the feasibility and safety of such extensive surgeries. CI - Copyright © 2016 Elsevier Ltd. All rights reserved. FAU - Benhaim, L AU - Benhaim L AD - Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, France. FAU - Honoré, C AU - Honoré C AD - Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, France. FAU - Goéré, D AU - Goéré D AD - Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, France. FAU - Delhorme, J-B AU - Delhorme JB AD - Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, France. FAU - Elias, D AU - Elias D AD - Department of Surgical Oncology, Gustave Roussy, Cancer Campus, Grand Paris, France. Electronic address: dominique.elias@gustaveroussy.fr. LA - eng PT - Journal Article DEP - 20160201 PL - England TA - Eur J Surg Oncol JT - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JID - 8504356 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Cytoreduction Surgical Procedures/methods/*standards MH - Female MH - Follow-Up Studies MH - Humans MH - Laparotomy/methods/standards MH - Male MH - Middle Aged MH - *Neoplasm Staging MH - Peritoneal Neoplasms/*diagnosis/surgery MH - *Practice Guidelines as Topic MH - Pseudomyxoma Peritonei/*diagnosis/surgery MH - Retrospective Studies MH - Tomography, X-Ray Computed MH - Treatment Outcome MH - Young Adult OTO - NOTNLM OT - Cytoreduction OT - HIPEC OT - Peritoneal neoplasms OT - Pseudomyxoma peritonei OT - Surgical procedures EDAT- 2016/02/13 06:00 MHDA- 2016/08/03 06:00 CRDT- 2016/02/13 06:00 PHST- 2015/10/08 00:00 [received] PHST- 2015/12/31 00:00 [revised] PHST- 2016/01/18 00:00 [accepted] PHST- 2016/02/13 06:00 [entrez] PHST- 2016/02/13 06:00 [pubmed] PHST- 2016/08/03 06:00 [medline] AID - S0748-7983(16)00057-3 [pii] AID - 10.1016/j.ejso.2016.01.015 [doi] PST - ppublish SO - Eur J Surg Oncol. 2016 Apr;42(4):552-7. doi: 10.1016/j.ejso.2016.01.015. Epub 2016 Feb 1. PMID- 35083718 OWN - NLM STAT- MEDLINE DCOM- 20220324 LR - 20220324 IS - 1179-2019 (Electronic) IS - 1174-5878 (Linking) VI - 24 IP - 2 DP - 2022 Mar TI - Safety of Ferric Carboxymaltose in Children: Report of a Case Series from Greece and Review of the Literature. PG - 137-146 LID - 10.1007/s40272-022-00491-5 [doi] AB - BACKGROUND: Parenteral iron is generally considered safe in adults, and severe adverse events are extremely rare. Ferric carboxymaltose (FCM), a third-generation parenteral iron product, is not licensed for pediatric use. OBJECTIVE: The aim of this study was to present our data on the safety of FCM in children with iron deficiency (ID) and/or iron deficiency anemia (IDA) and to investigate through a systematic literature review articles reporting on the safety of FCM use in children with ID/IDA. PATIENTS AND METHODS: Safety data regarding children treated with FCM for ID/IDA from four pediatric departments in Greece over a 26-month period are presented. Additionally, a literature search was performed in PubMed, Scopus, and Google Scholar on December 4, 2021 for articles reporting on the use of FCM in children with ID/IDA. Review articles, guidelines, case reports/case series, and reports on the use of FCM for conditions other than ID/IDA were excluded. Identified articles were screened for all reported adverse events (AE) that were graded according to the Common Terminology Criteria for Adverse Events, version 5.0. RESULTS: In our cohort, 37 children with ID/IDA received 41 FCM infusions. All infusions were tolerated well. In addition, 11 articles reporting 1231 infusions of FCM in 866 children were identified in the literature. Among them, 52 (6%) children developed AE that were graded as mild or moderate (grades I-III). CONCLUSIONS: Our patient cohort and this literature review provide further evidence for the good safety profile of FCM in children, although well-designed prospective clinical trials with appropriate safety endpoints are still required. CI - © 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Panagopoulou, Paraskevi AU - Panagopoulou P AD - 4th Department of Pediatrics, Papageorgiou General Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Alexiadou, Sonia AU - Alexiadou S AD - Department of Pediatrics, Faculty of Medicine, Democritus University of Thrace, 6th Kilometer Alexandroupolis-Makris, 68 100, Alexandroupolis, Thrace, Greece. FAU - Ntoumpara, Maria AU - Ntoumpara M AD - 4th Department of Pediatrics, Papageorgiou General Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Papazoglou, Anna AU - Papazoglou A AD - Department of Pediatrics, Faculty of Medicine, Democritus University of Thrace, 6th Kilometer Alexandroupolis-Makris, 68 100, Alexandroupolis, Thrace, Greece. FAU - Makis, Alexandros AU - Makis A AD - Department of Pediatrics, Faculty of Medicine, University of Ioannina, Ioannina, Greece. FAU - Tragiannidis, Athanasios AU - Tragiannidis A AD - 2nd Department of Pediatrics, AHEPA University Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Fotoulaki, Maria AU - Fotoulaki M AD - 4th Department of Pediatrics, Papageorgiou General Hospital, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Mantadakis, Elpis AU - Mantadakis E AUID- ORCID: 0000-0001-7837-9733 AD - Department of Pediatrics, Faculty of Medicine, Democritus University of Thrace, 6th Kilometer Alexandroupolis-Makris, 68 100, Alexandroupolis, Thrace, Greece. emantada@med.duth.gr. LA - eng PT - Case Reports PT - Journal Article PT - Systematic Review DEP - 20220127 PL - Switzerland TA - Paediatr Drugs JT - Paediatric drugs JID - 100883685 RN - 0 (Ferric Compounds) RN - 6897GXD6OE (ferric carboxymaltose) RN - 69-79-4 (Maltose) SB - IM MH - Adult MH - Child MH - *Ferric Compounds/adverse effects MH - Greece MH - Humans MH - *Maltose/adverse effects/analogs & derivatives MH - Prospective Studies EDAT- 2022/01/28 06:00 MHDA- 2022/03/25 06:00 CRDT- 2022/01/27 05:52 PHST- 2022/01/05 00:00 [accepted] PHST- 2022/01/28 06:00 [pubmed] PHST- 2022/03/25 06:00 [medline] PHST- 2022/01/27 05:52 [entrez] AID - 10.1007/s40272-022-00491-5 [pii] AID - 10.1007/s40272-022-00491-5 [doi] PST - ppublish SO - Paediatr Drugs. 2022 Mar;24(2):137-146. doi: 10.1007/s40272-022-00491-5. Epub 2022 Jan 27. PMID- 33155916 OWN - NLM STAT- MEDLINE DCOM- 20220117 LR - 20220117 IS - 1875-5992 (Electronic) IS - 1871-5206 (Linking) VI - 21 IP - 12 DP - 2021 TI - Theoretical Study of the Process of Passage of Glycoside Amides through the Cell Membrane of Cancer Cell. PG - 1612-1623 LID - 10.2174/1871520620999201103201008 [doi] AB - BACKGROUND: This article concentrates on the processes occurring in the medium around the cancer cell and the transfer of glycoside amides through their cell membrane. They are obtained by modification of natural glycoside-nitriles (cyano-glycosides). Hydrolysis of starting materials in the blood medium and associated volume around physiologically active healthy and cancer cells, based on quantum-chemical semiempirical methods, are considered. OBJECTIVE: Based on the fact that the cancer cell feeds primarily on carbohydrates, it is likely that organisms have adapted to take food containing nitrile glycosides and/or modified forms to counteract "external" bioactive activity. For their part, cancers have evolved to create conditions around their cells that eliminate their active apoptotic forms. This is far more appropriate for them than changing their entire enzyme regulation to counteract it. In this way, it protects itself and the gene sets and develops accordingly. METHODS: Pedestal is derived that closely defines the processes of hydrolysis in the blood, the transfer of a specific molecular hydrolytic form to the cancer cell membrane and with the help of time-dependent densityfunctional quantum-chemical methods, its passage and the processes of re-hydrolysis within the cell itself, to bioactive forms causing chemical apoptosis of the cell-independent of its non-genetic set, which seeks to counteract the process. RESULTS: Used in oncology, it could turn a cancer from a lethal to a chronic disease (such as diabetes). The causative agent and conditions for the development of the disease are not eliminated, but the amount of cancer cells could be kept low for a long time (even a lifetime). CONCLUSION: The amide derivatives of nitrile glycosides exhibit anticancer activity; the cancer cell probably seeks to displace hydrolysis of these derivatives in a direction that would not pass through its cell membrane and the amide-carboxyl derivatives of nitrile glycosides could deliver extremely toxic compounds within the cancer cell itself and thus block and/or permanently damage its normal physiology. CI - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Tsanov, Vasil AU - Tsanov V AD - Academy of Ministry of Interior, Fire Safety and Civil Protection, Sofia, Bulgaria. FAU - Tsanov, Hristo AU - Tsanov H AD - Academy of Ministry of Interior, Fire Safety and Civil Protection, Sofia, Bulgaria. LA - eng PT - Journal Article PL - Netherlands TA - Anticancer Agents Med Chem JT - Anti-cancer agents in medicinal chemistry JID - 101265649 RN - 0 (Amides) RN - 0 (Antineoplastic Agents) RN - 0 (Glycosides) SB - IM MH - Amides/chemistry/*pharmacology MH - Antineoplastic Agents/chemistry/*pharmacology MH - Apoptosis/drug effects MH - Cell Membrane/*drug effects/metabolism MH - *Density Functional Theory MH - Drug Screening Assays, Antitumor MH - Glycosides/chemistry/*pharmacology MH - Humans MH - Hydrolysis MH - Molecular Structure MH - Neoplasms/*drug therapy/metabolism/pathology OTO - NOTNLM OT - Glycoside amides OT - PM7 OT - TD-DFT OT - apoptosis OT - cancer cell membrane OT - hydrolysis EDAT- 2020/11/07 06:00 MHDA- 2022/01/18 06:00 CRDT- 2020/11/06 12:11 PHST- 2020/05/07 00:00 [received] PHST- 2020/09/02 00:00 [revised] PHST- 2020/09/06 00:00 [accepted] PHST- 2020/11/07 06:00 [pubmed] PHST- 2022/01/18 06:00 [medline] PHST- 2020/11/06 12:11 [entrez] AID - ACAMC-EPUB-111167 [pii] AID - 10.2174/1871520620999201103201008 [doi] PST - ppublish SO - Anticancer Agents Med Chem. 2021;21(12):1612-1623. doi: 10.2174/1871520620999201103201008. PMID- 25816436 OWN - NLM STAT- MEDLINE DCOM- 20151026 LR - 20250103 IS - 1942-602X (Print) IS - 1942-602X (Linking) VI - 30 IP - 2 DP - 2015 Mar TI - Students requiring personal nursing care in school: nursing care models and a checklist for school nurses. PG - 76-80 LID - 10.1177/1942602X15569781 [doi] AB - Unprecedented numbers of children in the United States are now surviving extreme conditions and complications of prematurity, severe congenital anomalies, and significant birth trauma. Advances in medical science and technology have given rise to a marked increase in the population of children with special health care needs who require continuous nursing care, including at school. Students who are considered medically complex and/or are health technology-dependent present many rewards and challenges for families, educational staff, district administrators, and school nurses who may not feel prepared to integrate involved health care for students into the school setting. The purpose of this article is to describe care delivery models for success in providing for the health and safety needs of students who require continuous or personal nursing care at school. CI - © 2015 The Author(s). FAU - Shannon, Robin Adair AU - Shannon RA AD - Clinical Instructor, University of Illinois at Chicago, College of Nursing, Chicago, IL. FAU - Minchella, Lindsey AU - Minchella L AD - West Lafayette, IN. LA - eng PT - Journal Article DEP - 20150130 PL - United States TA - NASN Sch Nurse JT - NASN school nurse (Print) JID - 101528330 MH - Child MH - Developmental Disabilities/*nursing MH - Children with Disabilities/*education MH - Female MH - Humans MH - Intellectual Disability/*nursing MH - Male MH - *Nurse's Role MH - Organizational Innovation MH - School Health Services/organization & administration MH - School Nursing/*organization & administration MH - United States OTO - NOTNLM OT - individualized education program OT - school health services OT - school nurse OT - students with disabilities OT - students with special health care needs EDAT- 2015/03/31 06:00 MHDA- 2015/10/27 06:00 CRDT- 2015/03/28 06:00 PHST- 2015/03/28 06:00 [entrez] PHST- 2015/03/31 06:00 [pubmed] PHST- 2015/10/27 06:00 [medline] AID - 1942602X15569781 [pii] AID - 10.1177/1942602X15569781 [doi] PST - ppublish SO - NASN Sch Nurse. 2015 Mar;30(2):76-80. doi: 10.1177/1942602X15569781. Epub 2015 Jan 30. PMID- 37624232 OWN - NLM STAT- MEDLINE DCOM- 20230828 LR - 20230908 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 15 IP - 8 DP - 2023 Jul 25 TI - Research Progress Related to Aflatoxin Contamination and Prevention and Control of Soils. LID - 10.3390/toxins15080475 [doi] LID - 475 AB - Aflatoxins are potent carcinogenic compounds, mainly produced by fungi species of the genus Aspergillus in the soil. Because of their stability, they are difficult to remove completely, even under extreme conditions. Aflatoxin contamination is one of the main causes of safety in peanuts, maize, wheat and other agricultural products. Aflatoxin contamination originates from the soil. Through the investigation of soil properties and soil microbial distribution, the sources of aflatoxin are identified, aflatoxin contamination is classified and analysed, and post-harvest crop detoxification and corresponding contamination prevention measures are identified. This includes the team's recent development of the biofungicide ARC-BBBE (Aflatoxin Rhizobia Couple-B. amyloliquefaciens, B. laterosporu, B. mucilaginosus, E. ludwiggi) for field application and nanomaterials for post-production detoxification of cereals and oilseed crops, providing an effective and feasible approach for the prevention and control of aflatoxin contamination. Finally, it is hoped that effective preventive and control measures can be applied to a large number of cereal and oilseed crops. FAU - Wang, Xue AU - Wang X AUID- ORCID: 0009-0003-4749-4749 AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. AD - Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. AD - Hubei Hongshan Laboratory, Wuhan 430061, China. FAU - Wang, Dun AU - Wang D AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. AD - Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. AD - Hubei Hongshan Laboratory, Wuhan 430061, China. FAU - Zhang, Shujuan AU - Zhang S AUID- ORCID: 0000-0003-4266-7172 AD - Zhejiang Mariculture Research Institution, Wenzhou 325000, China. FAU - Zhu, Mengjie AU - Zhu M AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. FAU - Yang, Qing AU - Yang Q AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. FAU - Dong, Jing AU - Dong J AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. FAU - Zhang, Qi AU - Zhang Q AD - Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China. AD - Hubei Hongshan Laboratory, Wuhan 430061, China. FAU - Feng, Peng AU - Feng P AD - Xiangyang Academy of Agricultural Sciences, Xiangyang 441057, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20230725 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 0 (Aflatoxins) RN - 0 (Soil) RN - 9N2N2Y55MH (Aflatoxin B1) SB - IM MH - *Aflatoxins MH - Soil MH - Aflatoxin B1 MH - Agriculture MH - Arachis MH - Crops, Agricultural MH - Edible Grain PMC - PMC10467090 OTO - NOTNLM OT - ARC-BBBE OT - Aspergillus flavus OT - aflatoxin OT - aflatoxin contamination OT - aflatoxin control OT - soil COIS- The authors declare no conflict of interest. EDAT- 2023/08/25 12:42 MHDA- 2023/08/28 06:41 PMCR- 2023/07/25 CRDT- 2023/08/25 10:43 PHST- 2023/05/19 00:00 [received] PHST- 2023/07/20 00:00 [revised] PHST- 2023/07/21 00:00 [accepted] PHST- 2023/08/28 06:41 [medline] PHST- 2023/08/25 12:42 [pubmed] PHST- 2023/08/25 10:43 [entrez] PHST- 2023/07/25 00:00 [pmc-release] AID - toxins15080475 [pii] AID - toxins-15-00475 [pii] AID - 10.3390/toxins15080475 [doi] PST - epublish SO - Toxins (Basel). 2023 Jul 25;15(8):475. doi: 10.3390/toxins15080475. PMID- 28027156 OWN - NLM STAT- MEDLINE DCOM- 20170630 LR - 20181202 IS - 1538-5159 (Electronic) IS - 0017-9078 (Linking) VI - 112 IP - 2 DP - 2017 Feb TI - Education vs. Training: Does it Matter? PG - 165-171 LID - 10.1097/HP.0000000000000622 [doi] AB - The National Council on Radiation Protection and Measurements' (NCRP) "Where are the Radiation Professionals?" initiative brought renewed attention to the declining numbers of individuals in radiation protection fields. This paper is an expanded version of the oral presentation by the author at the 2016 NCRP Annual Meeting. Health physics (HP) as a discipline and vocation is at a critical juncture. Perhaps less well recognized is the extreme peril facing academic HP programs. Higher education today is vastly different from what it was even 20 y ago. Every academic program must now make a budget case to justify its existence. Consequently, HP programs, which are by anyone's measure minuscule, are in very real danger of closing. Given that the country will continue to need radiation protection expertise, we must take immediate steps to reinvigorate the profession and preserve academic programs. We simply cannot train or short-course our way out of this problem. Under routine conditions, individuals trained in basic HP can be expected to safely manage daily operations. But life is full of the unexpected. When the unexpected event involves radiation, we need someone well-versed in radiological fundamentals to understand, assess and safely deal with the problem. A three-pronged approach to bolster academic programs was offered: (1) increase academic cooperation and provide an infusion of cash, (2) more formally recognize the discipline of HP and increase respect for its role in safety, and (3) regulate who can be designated as a health physicist while increasing retention of individuals within the discipline. FAU - Higley, Kathryn A AU - Higley KA AD - *Oregon State University, 100 Radiation Center, Corvallis, OR 97331. LA - eng PT - Journal Article PL - United States TA - Health Phys JT - Health physics JID - 2985093R SB - IM MH - Career Choice MH - Education, Professional/trends MH - Employment/trends MH - Health Physics/*education/trends MH - Health Services Needs and Demand/*trends MH - Health Workforce/*trends MH - Preceptorship/*trends MH - *Radiation Protection MH - United States EDAT- 2016/12/28 06:00 MHDA- 2017/07/01 06:00 CRDT- 2016/12/28 06:00 PHST- 2016/12/28 06:00 [entrez] PHST- 2016/12/28 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] AID - 00004032-201702000-00010 [pii] AID - 10.1097/HP.0000000000000622 [doi] PST - ppublish SO - Health Phys. 2017 Feb;112(2):165-171. doi: 10.1097/HP.0000000000000622. PMID- 39365573 OWN - NLM STAT- MEDLINE DCOM- 20241004 LR - 20241004 IS - 0032-5422 (Print) IS - 0032-5422 (Linking) VI - 70 IP - 3 DP - 2024 Sep 30 TI - [Cruciferous vegetables In Hashimoto’s disease diet]. PG - 413-419 LID - 10.18388/pb.2021_547 [doi] AB - Thyroid is an endocrine gland that is responsible for producing and releasing two hormones: triiodothyronine (T3) and thyroxine (T4). Hypothyroidism as the disorder happens when the synthesis of those hormones is impaired. It is most commonly caused by the chronic autoimmune inflammation of the thyroid, referred to as Hashimoto’s disease. In this case, apart from the pharmacological treatment, diet does matter a great deal, too. It is extremely important to provide the body with all the essential nutrients. Exclusion of products that may interfere with the uptake of iodine - the trace element that is indispensable for the thyroid gland hormone synthesis, seems to be crucial, too. They most of all include cruciferous vegetables containing goitrogens (goitrogenic substances). This review aimed to collect and summarize the available scientific data on the safety of the cruciferous vegetable consumption within the context of its impact upon the thyroid function. FAU - Dobiecka, Dominika AU - Dobiecka D AD - Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku. FAU - Moskwa, Justyna AU - Moskwa J AD - Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku. FAU - Markiewicz-Żukowska, Renata AU - Markiewicz-Żukowska R AD - Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku. FAU - Socha, Katarzyna AU - Socha K AD - Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku. FAU - Naliwajko, Sylwia AU - Naliwajko S AD - Zakład Bromatologii, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Uniwersytet Medyczny w Białymstoku. LA - pol PT - English Abstract PT - Journal Article PT - Review TT - Warzywa krzyżowe w diecie pacjentów z chorobą Hashimoto. DEP - 20240917 PL - Poland TA - Postepy Biochem JT - Postepy biochemii JID - 0023525 SB - IM MH - *Hashimoto Disease/metabolism MH - Humans MH - *Vegetables MH - Diet MH - Thyroid Gland/metabolism MH - Brassicaceae EDAT- 2024/10/04 12:43 MHDA- 2024/10/04 12:44 CRDT- 2024/10/04 11:27 PHST- 2024/04/04 00:00 [received] PHST- 2024/05/08 00:00 [accepted] PHST- 2024/10/04 12:44 [medline] PHST- 2024/10/04 12:43 [pubmed] PHST- 2024/10/04 11:27 [entrez] AID - 10.18388/pb.2021_547 [doi] PST - epublish SO - Postepy Biochem. 2024 Sep 17;70(3):413-419. doi: 10.18388/pb.2021_547. Print 2024 Sep 30. PMID- 25573827 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20150214 LR - 20200929 IS - 1092-8472 (Print) IS - 1092-8472 (Linking) VI - 13 IP - 1 DP - 2015 Mar TI - Safety of Immunomodulators and Anti-TNF Therapy in Pregnancy. PG - 77-89 LID - 10.1007/s11938-014-0037-4 [doi] AB - Biologics have proved to be extremely effective therapies for active, difficult to treat ulcerative colitis and Crohn's disease. Given that active disease appears to be what drives worse outcomes in conception and pregnancy, understanding of the potential risks of continued biologic therapy during pregnancy is important. Knowledge of the mechanisms of placental transfer helps clinicians explain to patients the timing of potential cessation of therapy, and the ongoing data collection from the efforts of the Crohn's and Colitis Pregnancy Registry have helped immensely to move this field forward. The body of evidence for use of thiopurines as well has supported their continued use during pregnancy in patients, despite their category D rating. Family planning and counseling have come a long way with our efforts in understanding that the real enemy is active inflammation, not the therapies we use to treat it. FAU - Chaudrey, Khadija H AU - Chaudrey KH AD - Department of Gastroenterology and Hepatology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA, drkchaudrey@gmail.com. FAU - Kane, Sunanda V AU - Kane SV LA - eng PT - Journal Article PL - United States TA - Curr Treat Options Gastroenterol JT - Current treatment options in gastroenterology JID - 9815941 EDAT- 2015/01/13 06:00 MHDA- 2015/01/13 06:01 CRDT- 2015/01/10 06:00 PHST- 2015/01/10 06:00 [entrez] PHST- 2015/01/13 06:00 [pubmed] PHST- 2015/01/13 06:01 [medline] AID - 10.1007/s11938-014-0037-4 [doi] PST - ppublish SO - Curr Treat Options Gastroenterol. 2015 Mar;13(1):77-89. doi: 10.1007/s11938-014-0037-4. PMID- 19927362 OWN - NLM STAT- MEDLINE DCOM- 20100219 LR - 20131121 IS - 1098-1101 (Electronic) IS - 0733-2459 (Linking) VI - 24 IP - 6 DP - 2009 TI - Long-term plasma exchange for severe refractory hypertriglyceridemia: a decade of experience demonstrates safety and efficacy. PG - 254-8 LID - 10.1002/jca.20224 [doi] AB - Hypertriglyceridemia (hyperTG) is a common form of dyslipidemia and is frequently associated with premature coronary disease, and when severe, recurrent events of pancreatitis may occur. The management of hyperTG is generally medical (life style modification, medications). Plasma exchange (PE) has been reported to be useful in emergency situations particularly when acute pancreatitis results from extreme hyperTG. To our knowledge, there is only one report on long-term use of PE for hyperTG. We here report our results of long-term treatment of hyperTG in 6 patients with Frederickson Type V hyperlipidemia who had recurrent attacks of pancreatitis due to hyperTG refractory to medical therapy. PE was performed from one to eight times a month, mostly using a Cobe Spectra apparatus. In total, our center has performed a total of 1,593 PE sessions for hyperTG. There were no safety issues associated with PE for hyperTG other than occasional access problems (clotted fistula, IV access problems). Determination of plasma TG levels before and after PE demonstrated high efficiency of TG removal (42% to 58% reduction). There was marked clinical improvement in recurrent pancreatitis; patients had a major decrease in episodes (39% to 100%) while on regular PE, as long as they adhered to the treatment schedule. We conclude that long-term PE for hyperTG, while costly, is feasible and safe and may reduce recurrent attacks of pancreatitis. FAU - Schaap-Fogler, Michal AU - Schaap-Fogler M AD - Faculty of Medicine, Hadassah University Hospital, Jerusalem, Israel. FAU - Schurr, Daniel AU - Schurr D FAU - Schaap, Tova AU - Schaap T FAU - Leitersdorf, Eran AU - Leitersdorf E FAU - Rund, Deborah AU - Rund D LA - eng PT - Journal Article PL - United States TA - J Clin Apher JT - Journal of clinical apheresis JID - 8216305 RN - 13838-07-8 (acid citrate dextrose) RN - 2968PHW8QP (Citric Acid) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Acute Disease MH - Adult MH - Citric Acid/pharmacology MH - Glucose/analogs & derivatives/pharmacology MH - Humans MH - Hypertriglyceridemia/complications/*therapy MH - Male MH - Middle Aged MH - Pancreatitis/*prevention & control MH - *Plasma Exchange/adverse effects EDAT- 2009/11/21 06:00 MHDA- 2010/02/20 06:00 CRDT- 2009/11/21 06:00 PHST- 2009/11/21 06:00 [entrez] PHST- 2009/11/21 06:00 [pubmed] PHST- 2010/02/20 06:00 [medline] AID - 10.1002/jca.20224 [doi] PST - ppublish SO - J Clin Apher. 2009;24(6):254-8. doi: 10.1002/jca.20224. PMID- 29699141 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1445-5781 (Print) IS - 1447-0578 (Electronic) IS - 1445-5781 (Linking) VI - 12 IP - 4 DP - 2013 Oct TI - What are the risks of the assisted reproductive technologies (ART) and how can they be minimized? PG - 151-158 LID - 10.1007/s12522-013-0156-y [doi] AB - Although assisted reproductive technologies (ART) have become established procedures performed around the world, there are still many unanswered questions regarding safety. Possible risks associated with infertility and ART include (1) those inherent to pregnancy, delivery, and childhood; (2) those associated with the infertility itself and its causes; and (3) risks iatrogenic to ART. Although there are many potential risks associated with ART, it has become clear that the major risk is multiple pregnancy and its consequences. Major efforts are warranted to reduce the risk of multiple gestations with IVF, but it is also clear that single-embryo transfer is not the solution in all cases. Moreover, several studies have now documented that perinatal outcomes are somewhat poorer in IVF singleton infants than in spontaneously conceived singletons, but it is not clear if this increased risk is due to the ART or the infertility. Concerns about the impact of abnormalities in genomic imprinting persist at this time, as do risks associated with the culture conditions and even our environment. Only time will tell if children born following ART are at any increased risk of developing certain chronic diseases as they age. In any case, the risks to IVF children and mothers are likely to remain higher than those for children and mothers conceived spontaneously without medical assistance. However, since there have been over 5 million births after ART worldwide, and the vast majority of pregnancies and children have been essentially "normal", it is obvious that any excess risk must be relatively small. The normality of most pregnancies mandates that extreme care be exercised in making any changes to current practice. FAU - Rebar, Robert W AU - Rebar RW AD - The American Society for Reproductive Medicine 1209 Montgomery Hwy 35216 Birmingham AL USA. LA - eng PT - Journal Article PT - Review DEP - 20130611 PL - Japan TA - Reprod Med Biol JT - Reproductive medicine and biology JID - 101213278 PMC - PMC5904622 OTO - NOTNLM OT - ART OT - Embryo OT - IVF OT - Neonatal outcomes OT - Risk EDAT- 2013/06/11 00:00 MHDA- 2013/06/11 00:01 PMCR- 2013/06/11 CRDT- 2018/04/28 06:00 PHST- 2013/03/08 00:00 [received] PHST- 2013/05/19 00:00 [accepted] PHST- 2018/04/28 06:00 [entrez] PHST- 2013/06/11 00:00 [pubmed] PHST- 2013/06/11 00:01 [medline] PHST- 2013/06/11 00:00 [pmc-release] AID - RMB20156 [pii] AID - 10.1007/s12522-013-0156-y [doi] PST - epublish SO - Reprod Med Biol. 2013 Jun 11;12(4):151-158. doi: 10.1007/s12522-013-0156-y. eCollection 2013 Oct. PMID- 11537618 OWN - NASA STAT- MEDLINE DCOM- 19991024 LR - 20191027 IS - 0022-4650 (Print) IS - 0022-4650 (Linking) VI - 27 IP - 5 DP - 1990 Sep-Oct TI - Psychosocial effects of adjustment in Antarctica: lessons for long-duration spaceflight. PG - 471-7 AB - This paper examines the utility of remote, isolated Antarctic research stations as analogs for long-duration spaceflights from the perspective of psychosocial processes of adaptation and adjustment. Certain features of the physical and man-made environments found in Antarctica are similar to those that will be encountered in outer space. In both settings, men and women are likely to experience a number of physiological and psychological changes in response to the extreme environmental conditions and the prolonged isolation and confinement. Biomedical research in Antarctica provides an opportunity to study the causes of these changes and to develop strategies for reducing the risks to health and well-being before they pose a serious threat to crew safety and mission success. A number of lessons for long-duration spaceflight are examined, including screening and selection of personnel; training programs designed to facilitate individual adjustment and group adaptation and minimize group conflict; identification of optimal leadership characteristics for small, isolated groups; an understanding of social dynamics and group "microcultures" necessary for the organization and management of small but heterogeneous groups; organization of work activities; facility design; and support infrastructure. FAU - Palinkas, L A AU - Palinkas LA AD - University of California, San Diego, La Jolla 92093, USA. LA - eng GR - DPP-871461/DP/NCCDPHP CDC HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - J Spacecr Rockets JT - Journal of spacecraft and rockets JID - 100971401 MH - Adaptation, Physiological MH - *Adaptation, Psychological MH - Antarctic Regions MH - Ergonomics MH - Female MH - *Group Processes MH - Humans MH - Interpersonal Relations MH - Leadership MH - Male MH - Personnel Selection MH - Personnel Staffing and Scheduling MH - *Social Isolation MH - Space Simulation MH - Stress, Psychological OID - NASA: 00024235 EDAT- 1990/09/01 00:00 MHDA- 2001/09/11 10:01 CRDT- 1990/09/01 00:00 PHST- 1990/09/01 00:00 [pubmed] PHST- 2001/09/11 10:01 [medline] PHST- 1990/09/01 00:00 [entrez] AID - 10.2514/3.26167 [doi] PST - ppublish SO - J Spacecr Rockets. 1990 Sep-Oct;27(5):471-7. doi: 10.2514/3.26167. PMID- 23088954 OWN - NLM STAT- MEDLINE DCOM- 20130517 LR - 20131121 IS - 1096-0295 (Electronic) IS - 0273-2300 (Linking) VI - 64 IP - 3 DP - 2012 Dec TI - Human safety risk assessment of lymph node angiomas observed in 2-year carcinogenicity studies in rats. PG - 435-41 LID - S0273-2300(12)00192-4 [pii] LID - 10.1016/j.yrtph.2012.10.006 [doi] AB - The occurrence of mesenteric lymph node angiomas (benign vascular neoplasms including lymphangioma and hemangioma) in untreated control rats in 2-year carcinogenicity studies can range from rare to common depending on the strain used. This lesion is most common in male rats. Factors and conditions that may contribute to the etiopathogenesis of lymph node angiomas in rats include: (1) genetic drift, (2) congenital/developmental malformation, (3) sinus vascular transformation/venous obstruction of outflow, (4) "inflammatory" pseudo-tumors, and/or (5) defects of endothelial lymphatic vascular secretion/permeability. Lymph node angiomas in humans are extremely rare, not reported in mesenteric lymph nodes, and more common in females than males. The evaluation of increased mesenteric lymph node angiomas in rats for overall human safety risk assessment of novel pharmaceutical therapeutics should consider: genotoxicity of the test article, occurrence of vascular neoplasms in other locations in rats and in mice, occurrence of proliferative vascular lesions in nonclinical toxicology studies in non-rodent species, dose/exposure response, and pathophysiologic/morphologic differences and similarities of lymph node angiomas between rats and humans. Angiomas are independent lesions from angiosarcomas and are not precursors for angiosarcomas in either humans or animals. Mesenteric lymph node angiomas in rats are unlikely to be relevant for human risk assessment of pharmaceutical agents. CI - Copyright © 2012 Elsevier Inc. All rights reserved. FAU - Radi, Zaher A AU - Radi ZA AD - Pfizer Worldwide Research and Development, Drug Safety R&D, Cambridge, MA 02140, USA. zaher.radi@pfizer.com FAU - Morton, Daniel AU - Morton D LA - eng PT - Journal Article DEP - 20121023 PL - Netherlands TA - Regul Toxicol Pharmacol JT - Regulatory toxicology and pharmacology : RTP JID - 8214983 SB - IM MH - Animals MH - Drug Design MH - *Drug-Related Side Effects and Adverse Reactions MH - Female MH - Hemangioma/epidemiology/*etiology MH - Humans MH - Lymph Nodes/pathology MH - Lymphangioma/epidemiology/*etiology MH - Male MH - Mesentery/pathology MH - Mice MH - Rats MH - Risk Assessment/methods MH - Sex Factors MH - Species Specificity EDAT- 2012/10/24 06:00 MHDA- 2013/05/18 06:00 CRDT- 2012/10/24 06:00 PHST- 2012/05/29 00:00 [received] PHST- 2012/10/06 00:00 [revised] PHST- 2012/10/09 00:00 [accepted] PHST- 2012/10/24 06:00 [entrez] PHST- 2012/10/24 06:00 [pubmed] PHST- 2013/05/18 06:00 [medline] AID - S0273-2300(12)00192-4 [pii] AID - 10.1016/j.yrtph.2012.10.006 [doi] PST - ppublish SO - Regul Toxicol Pharmacol. 2012 Dec;64(3):435-41. doi: 10.1016/j.yrtph.2012.10.006. Epub 2012 Oct 23. PMID- 33862434 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240222 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 216 DP - 2021 Apr 13 TI - iTRAQ-based quantitative proteomic analysis of low molybdenum inducing thymus atrophy and participating in immune deficiency-related diseases. PG - 112200 LID - S0147-6513(21)00311-0 [pii] LID - 10.1016/j.ecoenv.2021.112200 [doi] AB - Molybdenum is a trace element with extremely uneven distribution in the environment. It constitutes the active sites of molybdenum enzymes that can catalyze redox reactions in almost all organisms. In this study, a mouse model with a low molybdenum diet was established to investigate the differential protein expressions in the thymus and the mechanism of molybdenum regulating thymocyte development. Results showed that the thymus evidently atrophied, and the weight and organ index of the thymus substantially decreased under the condition of low molybdenum (P < 0.01). A total of 274 differentially expressed proteins (DEPs) were screened through isobaric tag for relative and absolute quantification; amongst them, ribosomal proteins (38) were the most abundant. Bioinformatics analysis revealed that DEPs were mainly involved in protein metabolism (18%), nucleus (15%) and nucleic acid binding activity (17%), corresponding to biological process, cellular component and molecular function, respectively. Moreover, DEPs induced by low molybdenum were enriched in 94 pathways, of which typical maps including ribosome, oxidative phosphorylation and systemic lupus erythematosus. Flow cytometry analysis indicated the prominent imbalances of CD4(+) and CD8(+) cell ratios (P < 0.05, P < 0.01), suggesting the disordered development of T cell subsets. Overall, low molybdenum resulted in thymus atrophy by interfering with ribosomal protein expression and protein metabolism. This study provides a data platform for revealing the linkage between molybdenum and thymus-dependent immunity. CI - Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Yan AU - Zhang Y AD - Henan Key Laboratory of Environmental and Animal Product Safety Henan University of Science and Technology, Luoyang 471003, Henan, China. FAU - Zhao, Jing AU - Zhao J AD - Henan Key Laboratory of Environmental and Animal Product Safety Henan University of Science and Technology, Luoyang 471003, Henan, China. FAU - Zhou, Bian-Hua AU - Zhou BH AD - Henan Key Laboratory of Environmental and Animal Product Safety Henan University of Science and Technology, Luoyang 471003, Henan, China. FAU - Tian, Er-Jie AU - Tian EJ AD - Henan Key Laboratory of Environmental and Animal Product Safety Henan University of Science and Technology, Luoyang 471003, Henan, China. FAU - Tian, Wei-Shun AU - Tian WS AD - College of Veterinary Medicine and Bio-safety Research Institute, Jeonbuk National University, Iksan 54596, South Korea. FAU - Wang, Hong-Wei AU - Wang HW AD - Henan Key Laboratory of Environmental and Animal Product Safety Henan University of Science and Technology, Luoyang 471003, Henan, China. Electronic address: wanghw@haust.edu.cn. LA - eng PT - Journal Article DEP - 20210413 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 SB - IM OTO - NOTNLM OT - Heavy metal OT - ITRAQ OT - Molybdenum OT - Proteomics OT - Ribosomal proteins EDAT- 2021/04/17 06:00 MHDA- 2021/04/17 06:01 CRDT- 2021/04/16 20:23 PHST- 2021/01/21 00:00 [received] PHST- 2021/03/10 00:00 [revised] PHST- 2021/03/25 00:00 [accepted] PHST- 2021/04/17 06:01 [medline] PHST- 2021/04/17 06:00 [pubmed] PHST- 2021/04/16 20:23 [entrez] AID - S0147-6513(21)00311-0 [pii] AID - 10.1016/j.ecoenv.2021.112200 [doi] PST - aheadofprint SO - Ecotoxicol Environ Saf. 2021 Apr 13;216:112200. doi: 10.1016/j.ecoenv.2021.112200. PMID- 33054614 OWN - NLM STAT- MEDLINE DCOM- 20210222 LR - 20210222 IS - 1545-0813 (Electronic) IS - 1059-924X (Linking) VI - 25 IP - 4 DP - 2020 Oct TI - Horticulture in Queensland Australia, COVID-19 Response. It Hasn't All Been Bad on Reflection. PG - 402-408 LID - 10.1080/1059924X.2020.1815620 [doi] AB - Australia and with that Queensland have been extremely fortunate with the impact of COVID-19. Queensland has only had 1,067 cases as of June 30, 2020, of which 78% have been overseas acquired. Australia and Queensland acted early to address COVID-19 by putting in place a range of strategies including travel bans (international and domestic), isolation measures, testing regimes, advice to business, economic support, and research funding. Agriculture was designated an essential business and as such has continued operating throughout the pandemic. They have however had to develop and implement COVID plans to keep workers safe. To help agricultural business establish plans information was developed by Safe Work Australia, National Farmers Federation and the Queensland Department of Workplace Health and Safety. Workforce issues were identified early, particularly seasonal workers (those who travel from their usual place of residence to another place to work). The Queensland Government enacted a directive about how seasonal workers were to be managed and also developed a guide specifically for horticulture to help manage their COVID-19 response. We provide two case studies demonstrating how agriculture has responded to COVID-19. Agriculture has successfully, in Queensland, adapted quickly to the changing work conditions due to COVID-19. This is due to all levels of government coming together with industry to find solutions. Some changes have had wider benefits such as improved sanitation, better communication and a greater recognition of seasonal worker needs. Being prepared and resilient has enabled agriculture to alleviate the impact on their businesses ensuring the health of all. FAU - Franklin, Richard C AU - Franklin RC AUID- ORCID: 0000-0003-1864-4552 AD - Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University , Townsville, Australia. FAU - O'Sullivan, Fiona AU - O'Sullivan F AD - Discipline of Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University , Townsville, Australia. LA - eng PT - Journal Article DEP - 20201015 PL - England TA - J Agromedicine JT - Journal of agromedicine JID - 9421530 SB - IM MH - COVID-19/epidemiology/*psychology MH - Farmers/statistics & numerical data MH - *Horticulture/statistics & numerical data MH - Humans MH - *Occupational Health MH - Queensland/epidemiology MH - Resilience, Psychological OTO - NOTNLM OT - COVID-19 OT - Queensland OT - WHS OT - horticulture OT - resilience OT - safety EDAT- 2020/10/16 06:00 MHDA- 2021/02/23 06:00 CRDT- 2020/10/15 17:08 PHST- 2020/10/16 06:00 [pubmed] PHST- 2021/02/23 06:00 [medline] PHST- 2020/10/15 17:08 [entrez] AID - 10.1080/1059924X.2020.1815620 [doi] PST - ppublish SO - J Agromedicine. 2020 Oct;25(4):402-408. doi: 10.1080/1059924X.2020.1815620. Epub 2020 Oct 15. PMID- 27678495 OWN - NLM STAT- MEDLINE DCOM- 20171012 LR - 20201209 IS - 1616-5195 (Electronic) IS - 1616-5187 (Linking) VI - 17 IP - 3 DP - 2017 Mar TI - Mechanically Robust and Transparent N-Halamine Grafted PVA-co-PE Films with Renewable Antimicrobial Activity. LID - 10.1002/mabi.201600304 [doi] AB - Antimicrobial polymeric films that are both mechanically robust and function renewable would have broad technological implications for areas ranging from medical safety and bioengineering to foods industry; however, creating such materials has proven extremely challenging. Here, a novel strategy is reported to create high-strength N-halamine incorporated poly(vinyl alcohol-co-ethylene) films (HAF films) with renewable antimicrobial activity by combining melt radical graft polymerization and reactive extrusion technique. The approach allows here the intrinsically rechargeable N-halamine moieties to be covalently incorporated into polymeric films with high biocidal activity and durability. The resulting HAF films exhibit integrated properties of robust mechanical strength, high transparency, rechargeable chlorination capability (>300 ppm), and long-term durability, which can effectively offer 3-5 logs CFU reduction against typical pathogenic bacterium Escherichia coli within a short contact time of 1 h, even at high organism conditions. The successful synthesis of HAF films also provides a versatile platform for exploring the applications of antimicrobial N-halamine moieties in a self-supporting, structurally adaptive, and function renewable form. CI - © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Si, Yang AU - Si Y AD - Fiber and Polymer Science, University of California, Davis, CA, 95616, USA. FAU - Cossu, Andrea AU - Cossu A AD - Food Science and Technology & Biological and Agricultural Engineering, University of California, Davis, CA, 95616, USA. FAU - Nitin, Nitin AU - Nitin N AD - Food Science and Technology & Biological and Agricultural Engineering, University of California, Davis, CA, 95616, USA. FAU - Ma, Yue AU - Ma Y AD - Fiber and Polymer Science, University of California, Davis, CA, 95616, USA. FAU - Zhao, Cunyi AU - Zhao C AD - Fiber and Polymer Science, University of California, Davis, CA, 95616, USA. FAU - Chiou, Bor-Sen AU - Chiou BS AD - Bioproduct Chemistry and Engineering, USDA/WRRC/ARS, Albany, CA, 94710, USA. FAU - Cao, Trung AU - Cao T AD - Bioproduct Chemistry and Engineering, USDA/WRRC/ARS, Albany, CA, 94710, USA. FAU - Wang, Dong AU - Wang D AD - Materials Science and Engineering, Wuhan Textile University, Wuhan, 430073, China. FAU - Sun, Gang AU - Sun G AD - Fiber and Polymer Science, University of California, Davis, CA, 95616, USA. LA - eng PT - Journal Article DEP - 20160928 PL - Germany TA - Macromol Biosci JT - Macromolecular bioscience JID - 101135941 RN - 0 (Anti-Infective Agents) RN - 0 (Biopolymers) RN - 0 (Ethylenes) RN - 9002-89-5 (Polyvinyl Alcohol) RN - 91GW059KN7 (ethylene) SB - IM MH - Anti-Infective Agents/*chemistry/pharmacology MH - Biopolymers/*chemistry/pharmacology MH - Escherichia coli/drug effects/pathogenicity MH - Ethylenes/*chemistry MH - Humans MH - Polyvinyl Alcohol/*chemistry MH - Staphylococcus aureus/drug effects/pathogenicity OTO - NOTNLM OT - N-halamine OT - antimicrobial OT - medical safety OT - polymeric films OT - renewable EDAT- 2016/09/30 06:00 MHDA- 2017/10/13 06:00 CRDT- 2016/09/29 06:00 PHST- 2016/07/21 00:00 [received] PHST- 2016/08/28 00:00 [revised] PHST- 2016/09/30 06:00 [pubmed] PHST- 2017/10/13 06:00 [medline] PHST- 2016/09/29 06:00 [entrez] AID - 10.1002/mabi.201600304 [doi] PST - ppublish SO - Macromol Biosci. 2017 Mar;17(3). doi: 10.1002/mabi.201600304. Epub 2016 Sep 28. PMID- 39477815 OWN - NLM STAT- MEDLINE DCOM- 20241030 LR - 20241106 IS - 1525-6049 (Electronic) IS - 0886-022X (Print) IS - 0886-022X (Linking) VI - 46 IP - 2 DP - 2024 Dec TI - The association of metabolic profile of folate with diabetic kidney disease: evidence from 2011-2020 cycles of the NHANES. PG - 2420830 LID - 10.1080/0886022X.2024.2420830 [doi] LID - 2420830 AB - AIMS: Diabetic kidney disease (DKD) develops in approximately 40% of patients with type 2 diabetes mellitus (T2DM). The role of folate metabolites in the progression from T2DM to DKD has not been clearly articulated. Our aim was to assess the association of folate metabolites with DKD. METHODS: We conducted a cross-sectional study sourced from the U.S. National Health and Nutrition Examination Survey from 2011 to 2020. Several forms of folate were measured. DKD was defined as diabetes with albuminuria or impaired glomerular filtration rate. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. RESULTS: Of the 3,461 diabetes patients, 1,349 (38.98%) were diagnosed with DKD. Serum total folate and 5-Methyl-THF were negatively associated with DKD, the OR for comparing extreme quintile were both 0.73 (0.57-0.94). However, a positive association of RBC folate, UMFA, Non-5-Methyl-THF, and MeFox with DKD was observed with extreme quintile OR of 1.41 (1.10-1.82), 1.60 (1.24-2.07), 1.53 (1.20-1.96), and 3.45 (2.65-4.50). Furthermore, the ratio of UMFA to 5-Methyl-THF exhibited a positive association with DKD, with extreme quintile OR of 1.94 (1.50-2.50). CONCLUSIONS: Our findings suggested that guidelines and interventions highlighting the importance of promoting 5-Methyl-THF and reducing UMFA might have significant benefit for the management of patients with diabetes. FAU - Liang, Yali AU - Liang Y AD - School of Public Health, Wannan Medical College, Wuhu, China. FAU - Ding, Lei AU - Ding L AD - School of Public Health, Wannan Medical College, Wuhu, China. FAU - Tao, Mengjun AU - Tao M AD - Health Management Center, Yijishan Hospital of Wannan Medical College, Wuhu, China. FAU - Zhu, Yu AU - Zhu Y AD - School of Public Health, Wannan Medical College, Wuhu, China. LA - eng PT - Journal Article DEP - 20241030 PL - England TA - Ren Fail JT - Renal failure JID - 8701128 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Folic Acid/blood MH - *Diabetic Nephropathies/blood/etiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Nutrition Surveys MH - Middle Aged MH - *Diabetes Mellitus, Type 2/complications/blood MH - United States/epidemiology MH - Glomerular Filtration Rate MH - Aged MH - Adult MH - Albuminuria MH - Metabolome MH - Logistic Models MH - Risk Factors PMC - PMC11533242 OAB - Of 3,461 diabetes patients, 1,349 (38.98%) were diagnosed with diabetic kidney disease (DKD).Serum total folate, 5-Methy-THF and the risk of DKD exhibited a negative association, characterized by a U-shaped relationship.RBC folate, serum non-5-methyl-THF and MeFox were positively associated with DKD, without a safety threshold. OABL- eng OTO - NOTNLM OT - Red cell folate OT - complication OT - diabetic kidney disease OT - serum folate COIS- No potential conflict of interest was reported by the author(s). EDAT- 2024/10/31 00:27 MHDA- 2024/10/31 00:28 PMCR- 2024/10/30 CRDT- 2024/10/30 23:43 PHST- 2024/10/31 00:28 [medline] PHST- 2024/10/31 00:27 [pubmed] PHST- 2024/10/30 23:43 [entrez] PHST- 2024/10/30 00:00 [pmc-release] AID - 2420830 [pii] AID - 10.1080/0886022X.2024.2420830 [doi] PST - ppublish SO - Ren Fail. 2024 Dec;46(2):2420830. doi: 10.1080/0886022X.2024.2420830. Epub 2024 Oct 30. PMID- 39053175 OWN - NLM STAT- MEDLINE DCOM- 20240812 LR - 20240812 IS - 1873-1716 (Electronic) IS - 0167-5877 (Linking) VI - 230 DP - 2024 Sep TI - Risk assessment of influenza transmission between workers and pigs on US indoor hog growing units. PG - 106232 LID - S0167-5877(24)00118-1 [pii] LID - 10.1016/j.prevetmed.2024.106232 [doi] AB - On pig farms ample opportunity exists for pig-to-human and human-to-pig (cross-species) influenza transmission. The purpose of this study was to assess the risks of cross-species influenza transmission within an indoor pig grower unit in the United States and to prioritize data gaps. Using the World Organization for Animal Health risk assessment framework we evaluated influenza transmission across two risk pathways: 1. What is the likelihood that based on current conditions on a single typical hog grower-finisher facility in the Midwest (US), during a single production cycle, at least one hog becomes infected with an influenza virus associated with swine (either H1N1, H3N2, or H1N2) [step 1a] and that at least one worker becomes infected as a result [step 1b] and that the worker develops symptoms [step 1c]? And 2. What is the likelihood that, based on current conditions on a single typical hog grower-finisher facility in the Midwest (US), during a single production cycle, at least one worker becomes infected with an influenza virus associated with people (either H1N1, H3N2, or H1N2) [step 2a] and that at least one pig becomes infected as a result [step 2b] and that the pig(s) develop(s) symptoms [step 2c]? Semi-quantitative probability and uncertainty assessments were based on literature review including passive and active influenza surveillance data. We assumed a typical pig-grower farm has capacity for 4,000 pigs, two workers, and minimal influenza control measures. Probability and uncertainty categories were assessed for each risk step and the combined risk pathway. The combined risk assessment for risk pathway one was estimated to be Very Low for H1N1 and H1N2 with an overall High level of uncertainty. The combined risk assessment for risk pathway two was estimated to be Extremely Low for H1N1 and H3N2 with a High degree of uncertainty. Scenario analyses in which influenza control measures were assumed to be implemented separately (implementing vaccinating sows, mass vaccinating incoming pigs or improved personal protective equipment adherence) showed no reduction in the combined risk category. When implementing three influenza control methods altogether, the combined risk could be reduced to Extremely Low for risk pathway one and remained Extremely Low for risk pathway two. This work highlights that multiple influenza control methods are needed to reduce the risks of inter-species influenza transmission on swine farms. CI - Copyright © 2024. Published by Elsevier B.V. FAU - Kontowicz, Eric AU - Kontowicz E AD - Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette 47907, Indiana. FAU - Moreno-Madriñan, Max AU - Moreno-Madriñan M AD - Global Health Program, DePauw University, Greencastle 46135, Indiana; Department of Global Health, Indiana University, Indianapolis 46202, Indiana. FAU - Clarke, Zenobya AU - Clarke Z AD - Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette 47907, Indiana. FAU - Ragland, Darryl AU - Ragland D AD - Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette 47907, Indiana. FAU - Beauvais, Wendy AU - Beauvais W AD - Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette 47907, Indiana. Electronic address: wbeauvai@purdue.edu. LA - eng PT - Journal Article DEP - 20240524 PL - Netherlands TA - Prev Vet Med JT - Preventive veterinary medicine JID - 8217463 SB - IM MH - Animals MH - *Orthomyxoviridae Infections/veterinary/transmission/epidemiology/virology MH - *Swine Diseases/transmission/virology/epidemiology MH - Swine MH - Risk Assessment MH - Humans MH - *Animal Husbandry/methods MH - Influenza A Virus, H3N2 Subtype MH - Midwestern United States/epidemiology MH - Influenza A Virus, H1N1 Subtype MH - United States/epidemiology MH - Influenza A virus MH - Influenza A Virus, H1N2 Subtype MH - Influenza, Human/transmission/epidemiology OTO - NOTNLM OT - Cross-species transmission OT - Influenza OT - Pig health OT - Worker safety COIS- Declaration of Competing Interest The authors have declared that no competing interests exist. EDAT- 2024/07/26 12:44 MHDA- 2024/08/13 00:42 CRDT- 2024/07/25 18:05 PHST- 2023/07/12 00:00 [received] PHST- 2024/05/10 00:00 [revised] PHST- 2024/05/14 00:00 [accepted] PHST- 2024/08/13 00:42 [medline] PHST- 2024/07/26 12:44 [pubmed] PHST- 2024/07/25 18:05 [entrez] AID - S0167-5877(24)00118-1 [pii] AID - 10.1016/j.prevetmed.2024.106232 [doi] PST - ppublish SO - Prev Vet Med. 2024 Sep;230:106232. doi: 10.1016/j.prevetmed.2024.106232. Epub 2024 May 24. PMID- 18788335 OWN - NLM STAT- MEDLINE DCOM- 20081023 LR - 20191111 IS - 1074-7583 (Print) IS - 1074-7583 (Linking) VI - 14 IP - 3 DP - 2008 Jul TI - Net monetary benefit of cost-effective rollover protective structures (CROPS): an estimate of the potential benefits of the CROPS research project. PG - 351-63 AB - This study builds on an earlier study to examine the net monetary benefit of installing cost-effective rollover protective structures (CROPS) instead of utilizing existing ROPS retrofits for all estimated non-ROPS tractors in the year 2004. With the conservative estimates used in the analyses, results indicate that compared to the baseline option (no protective structure), the Install-ROPS option results in a loss of $310 million to society, while the Install-CROPS option results in a net monetary benefit of $276 million over a 20-year period. A comprehensive sensitivity analysis indicated that, for the extreme values (estimates) used, the estimated net monetary benefit is most sensitive to the probability of tractor overturn. Break-even analysis indicated that the unit cost of intervention for the Install-CROPS option can increase by about 58% and still be able to pay for itself. Even when the minimal unit cost of intervention for ROPS is used, the payback period is reduced substantially for the Install-CROPS option, by almost half the payback period. Finally, compared to existing ROPS retrofits, the net monetary benefit is $586 million, representing an estimate of the potential benefits of the CROPS research. FAU - Owusu-Edusei, K Jr AU - Owusu-Edusei K Jr AD - Health Services Research and Evaluation Branch, Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS E-80, Atlanta, GA 30333, USA. kfo0@cdc.gov LA - eng PT - Journal Article PL - United States TA - J Agric Saf Health JT - Journal of agricultural safety and health JID - 9613956 SB - IM MH - Accident Prevention/*economics MH - Agriculture/*economics/*instrumentation MH - Cohort Studies MH - Cost-Benefit Analysis MH - *Equipment Design/economics/standards MH - *Equipment Safety/economics/standards MH - Humans MH - Off-Road Motor Vehicles/economics/standards MH - United States MH - Wounds and Injuries/prevention & control EDAT- 2008/09/16 09:00 MHDA- 2008/10/24 09:00 CRDT- 2008/09/16 09:00 PHST- 2008/09/16 09:00 [pubmed] PHST- 2008/10/24 09:00 [medline] PHST- 2008/09/16 09:00 [entrez] AID - 10.13031/2013.24568 [doi] PST - ppublish SO - J Agric Saf Health. 2008 Jul;14(3):351-63. doi: 10.13031/2013.24568. PMID- 37929507 OWN - NLM STAT- MEDLINE DCOM- 20231107 LR - 20231214 IS - 2045-9912 (Electronic) IS - 2045-9912 (Linking) VI - 14 IP - 2 DP - 2024 Apr-Jun TI - Therapeutic effect of hydrogen and its mechanisms in kidney disease treatment. PG - 48-53 LID - 10.4103/2045-9912.378880 [doi] AB - Hydrogen is a simple, colorless, and biologically active small molecule gas that can react with reactive oxygen species. Recent research suggests that hydrogen possesses several biological effects, including antioxidant, anti-inflammatory, and anti-apoptotic effects, while exhibiting an extremely high level of safety. Hydrogen application has shown promise in treating a range of acute and chronic diseases, both benign and malignant. Importantly, an increasing number of clinical studies on hydrogen have demonstrated its efficacy and safety in treating various diseases. This review highlights the beneficial effects of hydrogen in kidney diseases, summarizes potential mechanisms by which hydrogen may act in these diseases, and proposes several promising avenues for future research. FAU - Cheng, Jin AU - Cheng J AD - Naval Medical Center, Naval Medical University, Shanghai, China. FAU - Shi, Minmin AU - Shi M AD - Naval Medical Center, Naval Medical University, Shanghai, China. FAU - Sun, Xuejun AU - Sun X AD - Department of Naval Medicine, Naval Medical University; Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, China. FAU - Lu, Hongtao AU - Lu H AD - Department of Naval Medicine, Naval Medical University, Shanghai, China. LA - eng PT - Journal Article PT - Review PL - Australia TA - Med Gas Res JT - Medical gas research JID - 101564536 RN - 7YNJ3PO35Z (Hydrogen) RN - 0 (Antioxidants) RN - 0 (Reactive Oxygen Species) RN - YY9FVM7NSN (Hydrogen Sulfide) SB - IM MH - Humans MH - Hydrogen/pharmacology/therapeutic use MH - *Kidney Diseases/drug therapy MH - Antioxidants/pharmacology/therapeutic use MH - Reactive Oxygen Species MH - *Hydrogen Sulfide PMC - PMC10715323 OTO - NOTNLM OT - acute kidney injury OT - anti-apoptosis OT - anti-inflammation OT - anti-oxidation OT - chronic kidney disease OT - end-stage renal disease OT - hydrogen OT - therapeutic effect COIS- The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Editor note: Xuejun Sun is an Editorial Board member of Medical Gas Research. He was blinded from reviewing or making decisions on the manuscript. The article was subject to the journal's standard procedures, with peer review handled independently of this Editorial Board member and his research group. EDAT- 2023/11/06 06:42 MHDA- 2023/11/07 06:45 PMCR- 2023/06/19 CRDT- 2023/11/06 05:03 PHST- 2023/11/07 06:45 [medline] PHST- 2023/11/06 06:42 [pubmed] PHST- 2023/11/06 05:03 [entrez] PHST- 2023/06/19 00:00 [pmc-release] AID - MedGasRes_2024_14_2_48_378880 [pii] AID - MGR-14-48 [pii] AID - 10.4103/2045-9912.378880 [doi] PST - ppublish SO - Med Gas Res. 2024 Apr-Jun;14(2):48-53. doi: 10.4103/2045-9912.378880. PMID- 36927094 OWN - NLM STAT- MEDLINE DCOM- 20240913 LR - 20241122 IS - 1545-1550 (Electronic) IS - 1526-6028 (Linking) VI - 31 IP - 5 DP - 2024 Oct TI - Novel Self-Expanding Interwoven Nitinol Stent for Treating Femoropopliteal Artery Disease: 12-Month Results of Single-Center First-in-Man Study. PG - 955-963 LID - 10.1177/15266028231159243 [doi] AB - PURPOSE: To evaluate the safety and efficacy of Innospring(®) stent, a novel self-expanding interwoven nitinol stent, in treating femoropopliteal atherosclerotic lesions. METHODS: A prospective, single-center, single-arm, first-in-human study enrolled 15 patients (mean age 73.1 years; 13 men) to evaluate the safety and efficacy of the Innospring(®) stent monitored by core laboratories. The inclusion criteria were claudication or ischemic rest pain, de novo lesions or nonstented restenosis, >70% stenosis, lesion length <20 cm, and a reference vessel diameter of 4-7 mm. The primary safety endpoint was 30-day major adverse events. The primary efficacy end point was stent patency at 12 months. Follow-up evaluations were conducted at 30 days, 6 months, and 12 months. RESULTS: The lesion length was 6.1 ± 3.5 mm. Fourteen (93.3%) patients had lesions of the superficial femoral artery and 3 (20.0%) patients had lesions of the popliteal artery. Nine (60.0%) patients had moderate-to-severe calcified lesion. Technical and procedural success was 100%. No patients experienced major adverse events in the first 30 days. The Rutherford category showed significant and sustained improvement at 6 and 12 months. The 12-month follow-up radiographs obtained in 13 patients confirmed the absence of stent fractures in 100% of examinations. The cumulative primary stent patency rate at 6 and 12 months were 93.3% and 84.6%, respectively. CONCLUSION: Stenting of the superficial femoral and popliteal arteries using the Innospring(®) stent is safe and effective. This competing interwoven nitinol stent may provide superior stent integrity and fracture-resistance as well as serve areas under extreme mechanical stress. CLINICAL IMPACT: Endovascular recanalization is a widely accepted and recommended treatment for symptomatic peripheral artery diseases. The Innospring® stent is a novel self-expanding interwoven stent containing eight nitinol wires with additional radial force, fracture-resistance, and visibility under fluoroscopy. This first-in-human study using the Innospring® stent in patients with femoropopliteal occlusive disease reported that stenting of the superficial femoral and popliteal arteries using the Innospring® stent is safe and effective. This competing interwoven nitinol stent may provide an impressive stent integrity and fracture-resistance as well as serve areas under extreme mechanical stress. FAU - Yang, Shuofei AU - Yang S AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Ni, Qihong AU - Ni Q AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Wang, Weilun AU - Wang W AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Chen, Jiaquan AU - Chen J AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Guo, Xiangjiang AU - Guo X AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Ye, Meng AU - Ye M AUID- ORCID: 0000-0002-8125-6854 AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Zhang, Lan AU - Zhang L AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Xue, Guanhua AU - Xue G AUID- ORCID: 0000-0003-0272-3109 AD - Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20230316 PL - United States TA - J Endovasc Ther JT - Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists JID - 100896915 RN - 0 (Alloys) RN - 2EWL73IJ7F (nitinol) SB - IM MH - Humans MH - *Alloys MH - *Popliteal Artery/physiopathology/diagnostic imaging MH - *Femoral Artery/physiopathology/diagnostic imaging MH - Male MH - Aged MH - Female MH - Prospective Studies MH - Treatment Outcome MH - *Vascular Patency MH - *Prosthesis Design MH - *Peripheral Arterial Disease/therapy/physiopathology/diagnostic imaging MH - Time Factors MH - *Self Expandable Metallic Stents MH - Aged, 80 and over MH - Middle Aged MH - Endovascular Procedures/instrumentation/adverse effects MH - Constriction, Pathologic MH - Angioplasty, Balloon/instrumentation/adverse effects MH - Stents OTO - NOTNLM OT - endovascular therapy OT - femoropopliteal artery OT - peripheral artery disease OT - self-expanding interwoven nitinol stent COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2023/03/18 06:00 MHDA- 2024/09/15 20:22 CRDT- 2023/03/17 08:04 PHST- 2024/09/15 20:22 [medline] PHST- 2023/03/18 06:00 [pubmed] PHST- 2023/03/17 08:04 [entrez] AID - 10.1177/15266028231159243 [doi] PST - ppublish SO - J Endovasc Ther. 2024 Oct;31(5):955-963. doi: 10.1177/15266028231159243. Epub 2023 Mar 16. PMID- 28876807 STAT- Publisher ISBN- 987-91-85413-37-9 PB - Swedish Council on Health Technology Assessment (SBU) CTI - SBU Systematic Review Summaries DP - 2010 Aug BTI - Dietary Treatment of Diabetes: A Systematic Review AB - Conclusions: In type 2 diabetes, low-fat and moderate low-carbohydrate diets (30–40% of the energy from carbohydrates) have similar, favorable effects on HbA1c (long-term blood glucose) and bodyweight. The absence of sufficient-quality studies in people with diabetes prevents evaluation of the long-term effects of more extreme diets involving low-carbohydrate and high-fat intake, e.g., so-called “low-carb, high-fat” (LCHF) diets. Hence, safety aspects become particularly important in clinical follow-up of individuals who choose extreme low-carbohydrate diets (10–20% energy from carbohydrates). Limited scientific evidence shows that vegetables, legumes, and fish are beneficial for people with diabetes. These foods are important components of the current dietary recommendations in diabetes. The literature review did not reveal evidence for drawing conclusions on other key components of dietary recommendations, e.g., whole grain products and fat content. No scientific evidence has emerged either for or against changing the current dietary recommendations in diabetes. People with type 2 diabetes who regularly consume moderate amounts of alcohol have a lower morbidity and mortality from cardiovascular disease than do people who consume no alcohol. Obviously, advice on using alcohol must take into consideration pregnancy or the risk of alcohol abuse. People who drink coffee have a lower risk of cardiovascular disease than those who do not drink coffee. So-called “lifestyle intervention”, which combines advice for low-fat, high-fiber diets and increased physical activity, protects against the development of diabetes in people with impaired ability to manage and metabolize glucose (impaired glucose tolerance). The absence of sufficient-quality studies prevents evaluation of the importance of the distribution of nutritional intake, or the intake of proteins and whole grain products, throughout the day (24 hours). Also absent are studies addressing the effects of diet on quality of life and on the incidence of eye and renal complications. Many studies are under way to evaluate different diets in diabetes. As the results of high-quality studies become available, the conclusions of this report may need to be revised. CI - Copyright © 2010 by the Swedish Council on Health Technology Assessment. CN - Swedish Council on Health Technology Assessment LA - eng PT - Review PT - Book PL - Stockholm EDAT- 2010/08/01 00:00 CRDT- 2010/08/01 00:00 AID - NBK447999 [bookaccession] PMID- 36028832 OWN - NLM STAT- MEDLINE DCOM- 20220830 LR - 20240903 IS - 1476-069X (Electronic) IS - 1476-069X (Linking) VI - 21 IP - 1 DP - 2022 Aug 26 TI - Reducing disease and death from Artisanal and Small-Scale Mining (ASM) - the urgent need for responsible mining in the context of growing global demand for minerals and metals for climate change mitigation. PG - 78 LID - 10.1186/s12940-022-00877-5 [doi] LID - 78 AB - Artisanal and small-scale mining (ASM) takes place under extreme conditions with a lack of occupational health and safety. As the demand for metals is increasing due in part to their extensive use in 'green technologies' for climate change mitigation, the negative environmental and occupational consequences of mining practices are disproportionately felt in low- and middle-income countries. The Collegium Ramazzini statement on ASM presents updated information on its neglected health hazards that include multiple toxic hazards, most notably mercury, lead, cyanide, arsenic, cadmium, and cobalt, as well as physical hazards, most notably airborne dust and noise, and the high risk of infectious diseases. These hazards affect both miners and mining communities as working and living spaces are rarely separated. The impact on children and women is often severe, including hazardous exposures during the child-bearing age and pregnancies, and the risk of child labor. We suggest strategies for the mitigation of these hazards and classify those according to primordial, primary, secondary, and tertiary prevention. Further, we identify knowledge gaps and issue recommendations for international, national, and local governments, metal purchasers, and employers are given. With this statement, the Collegium Ramazzini calls for the extension of efforts to minimize all hazards that confront ASM miners and their families. CI - © 2022. The Author(s). FAU - Landrigan, Philip AU - Landrigan P AD - Program for Global Public Health and the Common Good, Global Observatory on Planetary Health, Boston College, Boston, USA. landrigp@bc.edu. AD - Centre Scientifique de Monaco, Monaco City, Monaco. landrigp@bc.edu. FAU - Bose-O'Reilly, Stephan AU - Bose-O'Reilly S AUID- ORCID: 0000-0003-0204-3103 AD - Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany. FAU - Elbel, Johanna AU - Elbel J AD - Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany. FAU - Nordberg, Gunnar AU - Nordberg G AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Lucchini, Roberto AU - Lucchini R AD - Institute of Occupational Health, University of Brescia, Brescia, Italy. FAU - Bartrem, Casey AU - Bartrem C AD - TerraGraphics International Foundation, Moscow, ID 83843, USA. FAU - Grandjean, Philippe AU - Grandjean P AD - Department of Environmental Health, Harvard T. H. Chan School of Public Health, Cambridge, MA, USA. FAU - Mergler, Donna AU - Mergler D AD - Centre de recherche interdisciplinaire sur le bien-être, la santé, la société et l'environnement (Center for Interdisciplinary Research in Health, Wellbeing, Society and Environment, Université du Québec à Montréal, Montreal, QC, Canada. FAU - Moyo, Dingani AU - Moyo D AD - School of Public Health, Faculty of Health Sciences, Occupational Health Division, University of the Witwatersrand, Johannesburg, Republic of South Africa. AD - Department of Community Medicine, Faculty of Medicine and Health, National University of Science and Technology, Bulawayo, Zimbabwe. AD - Department of Community Medicine, Faculty of Medicine and Health, Midlands State University, Gweru, Zimbabwe. FAU - Nemery, Benoit AU - Nemery B AD - Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. FAU - von Braun, Margrit AU - von Braun M AD - TerraGraphics International Foundation, Moscow, ID 83843, USA. AD - Environmental Science Program, University of Idaho, Moscow, ID 83843, USA. FAU - Nowak, Dennis AU - Nowak D AD - Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany. CN - Collegium Ramazzini LA - eng PT - Letter DEP - 20220826 PL - England TA - Environ Health JT - Environmental health : a global access science source JID - 101147645 RN - 0 (Metals) RN - 0 (Minerals) RN - 7440-57-5 (Gold) RN - FXS1BY2PGL (Mercury) SB - IM MH - Climate Change MH - Female MH - Gold MH - Humans MH - *Mercury MH - Metals MH - Minerals MH - Mining MH - *Occupational Exposure PMC - PMC9412790 OTO - NOTNLM OT - ASM OT - Environmental health OT - Global south OT - Green energy transition OT - Mining OT - Occupational health COIS- The authors declare that they have no competing interests. EDAT- 2022/08/27 06:00 MHDA- 2022/08/31 06:00 PMCR- 2022/08/26 CRDT- 2022/08/26 23:40 PHST- 2022/01/26 00:00 [received] PHST- 2022/06/27 00:00 [accepted] PHST- 2022/08/26 23:40 [entrez] PHST- 2022/08/27 06:00 [pubmed] PHST- 2022/08/31 06:00 [medline] PHST- 2022/08/26 00:00 [pmc-release] AID - 10.1186/s12940-022-00877-5 [pii] AID - 877 [pii] AID - 10.1186/s12940-022-00877-5 [doi] PST - epublish SO - Environ Health. 2022 Aug 26;21(1):78. doi: 10.1186/s12940-022-00877-5. PMID- 24287853 OWN - NLM STAT- MEDLINE DCOM- 20141009 LR - 20240519 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 10 IP - 12 DP - 2013 Nov 26 TI - Foodborne Campylobacter: infections, metabolism, pathogenesis and reservoirs. PG - 6292-304 LID - 10.3390/ijerph10126292 [doi] AB - Campylobacter species are a leading cause of bacterial-derived foodborne illnesses worldwide. The emergence of this bacterial group as a significant causative agent of human disease and their propensity to carry antibiotic resistance elements that allows them to resist antibacterial therapy make them a serious public health threat. Campylobacter jejuni and Campylobacter coli are considered to be the most important enteropathogens of this genus and their ability to colonize and survive in a wide variety of animal species and habitats make them extremely difficult to control. This article reviews the historical and emerging importance of this bacterial group and addresses aspects of the human infections they cause, their metabolism and pathogenesis, and their natural reservoirs in order to address the need for appropriate food safety regulations and interventions. FAU - Epps, Sharon V R AU - Epps SV AD - Food & Feed Safety Research Unit, Southern Plains Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, 2881 F&B Road, College Station, TX 77845, USA. robin.anderson@ars.usda.gov. FAU - Harvey, Roger B AU - Harvey RB FAU - Hume, Michael E AU - Hume ME FAU - Phillips, Timothy D AU - Phillips TD FAU - Anderson, Robin C AU - Anderson RC FAU - Nisbet, David J AU - Nisbet DJ LA - eng PT - Journal Article PT - Review DEP - 20131126 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Campylobacter/*physiology MH - Campylobacter Infections/*epidemiology/microbiology/pathology MH - *Disease Reservoirs/microbiology MH - Foodborne Diseases/*epidemiology/microbiology/pathology MH - Humans PMC - PMC3881114 EDAT- 2013/11/30 06:00 MHDA- 2014/10/10 06:00 PMCR- 2013/12/01 CRDT- 2013/11/30 06:00 PHST- 2013/09/10 00:00 [received] PHST- 2013/11/08 00:00 [revised] PHST- 2013/11/09 00:00 [accepted] PHST- 2013/11/30 06:00 [entrez] PHST- 2013/11/30 06:00 [pubmed] PHST- 2014/10/10 06:00 [medline] PHST- 2013/12/01 00:00 [pmc-release] AID - ijerph10126292 [pii] AID - ijerph-10-06292 [pii] AID - 10.3390/ijerph10126292 [doi] PST - epublish SO - Int J Environ Res Public Health. 2013 Nov 26;10(12):6292-304. doi: 10.3390/ijerph10126292. PMID- 37860145 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231021 IS - 2665-9271 (Electronic) IS - 2665-9271 (Linking) VI - 7 DP - 2023 TI - Design and development of a rapid meat detection system based on RPA-CRISPR/Cas12a-LFD. PG - 100609 LID - 10.1016/j.crfs.2023.100609 [doi] LID - 100609 AB - In recent years, meat adulteration safety incidents have occurred frequently, triggering widespread attention and discussion. Although there are a variety of meat quality identification methods, conventional assays require high standards for personnel and experimental conditions and are not suitable for on-site testing. Therefore, there is an urgent need for a rapid, sensitive, high specificity and high sensitivity on-site meat detection method. This study is the first to apply RPA combined with CRISPR/Cas12a technology to the field of multiple meat identification. The system developed by parameter optimization can achieve specific detection of chicken, duck, beef, pork and lamb with a minimum target sequence copy number as low as 1 × 10(0) copies/μL for 60 min at a constant temperature. LFD test results can be directly observed with the naked eye, with the characteristics of fast, portable and simple operation, which is extremely in line with current needs. In conclusion, the meat identification RPA-CRISPR/Cas12a-LFD system established in this study has shown promising applications in the field of meat detection, with a profound impact on meat quality, and provides a model for other food safety control programs. CI - © 2023 The Authors. FAU - Liu, Yaqun AU - Liu Y AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Lin, Liyun AU - Lin L AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Wei, Huagui AU - Wei H AD - Shool of Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, PR China. FAU - Luo, Qiulan AU - Luo Q AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Yang, Peikui AU - Yang P AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Liu, Mouquan AU - Liu M AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Wang, Zhonghe AU - Wang Z AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Zou, Xianghui AU - Zou X AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Zhu, Hui AU - Zhu H AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Zha, Guangcai AU - Zha G AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Sun, Junjun AU - Sun J AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. FAU - Zheng, Yuzhong AU - Zheng Y AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. AD - Shool of Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, PR China. FAU - Lin, Min AU - Lin M AD - School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou, Guangdong, PR China. AD - Guangdong Provincial Key Laboratory of Functional Substances in Medicinal Edible Resources and Healthcare Products, Chaozhou, Guangdong, PR China. AD - Shool of Laboratory Medicine, Youjiang Medical University for Nationalities, Baise, Guangxi, PR China. LA - eng PT - Journal Article DEP - 20231005 PL - Netherlands TA - Curr Res Food Sci JT - Current research in food science JID - 101771059 PMC - PMC10582345 OTO - NOTNLM OT - CRISPR/Cas12a OT - LFD OT - Meat identification OT - RPA COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/10/20 06:42 MHDA- 2023/10/20 06:43 PMCR- 2023/10/05 CRDT- 2023/10/20 04:28 PHST- 2023/05/15 00:00 [received] PHST- 2023/09/12 00:00 [revised] PHST- 2023/10/02 00:00 [accepted] PHST- 2023/10/20 06:43 [medline] PHST- 2023/10/20 06:42 [pubmed] PHST- 2023/10/20 04:28 [entrez] PHST- 2023/10/05 00:00 [pmc-release] AID - S2665-9271(23)00177-6 [pii] AID - 100609 [pii] AID - 10.1016/j.crfs.2023.100609 [doi] PST - epublish SO - Curr Res Food Sci. 2023 Oct 5;7:100609. doi: 10.1016/j.crfs.2023.100609. eCollection 2023. PMID- 39167302 OWN - NLM STAT- MEDLINE DCOM- 20241118 LR - 20241119 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 91 IP - 12 DP - 2024 Dec TI - Managing the Historic Burden of Kernicterus Mortality in India. PG - 1262-1267 LID - 10.1007/s12098-024-05227-6 [doi] AB - Prevention of neonatal bilirubin injury exemplifies success of systems approach to avert adverse neonatal and childhood outcomes that rely on strategies including prenatal identification of Rhesus sensitization, universal maternal blood typing, risk assessment for neonatal extreme hyperbilirubinemia (EHB), unfettered access to safe, effective phototherapy, and application of patient safety principles. India's diverse landscape suggests varied real-time experiences of neonatal hyperbilirubinemia and consequent infant mortality rates (IMR). Utilizing Global Burden of Disease (GBD) database, the authors examined national and subnational trends, infant mortality timing, and the disease burden from hemolytic and perinatal jaundice over 30 y (1999 to 2019). They also assessed the correlation of EHB-IMR with socio-demographic index and health expenditure per capita, estimating economic losses from EHB-related infant mortality to guide policy decisions at national and state domains. From 1990 to 2019, India delivered 811,078,415 livebirths of which, 1,189,856 infant deaths were due to EHB. EHB-related deaths decreased from 57,773 in 1990 to 19,664 in 2019, a 60% reduction vs. 40% in overall IMR. Early (0-6 d), late (7-27 d), and post-neonatal (28-364 d) deaths accounted for 61%, 34%, and 5% of mortality, respectively. Uttar Pradesh and Bihar contributed to 38% of all EHB deaths. Economic analysis estimate losses between US $7.2 and 11.7 billion for the year 2019 secondary to EHB-related mortality. The present analysis reveals consistent declines across all states to reach current EHB-IMR of 0.8 per 1,000 live-births in India by 2019. Significant economic impact of lost human productivity highlight ongoing need for targeted life-saving public health strategies. CI - © 2024. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Vidavalur, Ramesh AU - Vidavalur R AUID- ORCID: 0000-0003-1476-7619 AD - Department of Clinical Pediatrics, Cayuga Medical Center/Weill Cornell Medicine, 101 Dates Drive, Ithaca, NY, 14850, USA. rameshvidavalur@gmail.com. FAU - Bhutani, Vinod K AU - Bhutani VK AD - Stanford University School of Medicine, Lucile Salter Packard Children's Hospital, Stanford, CA, 94305, USA. LA - eng PT - Journal Article PT - Review DEP - 20240821 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - India/epidemiology MH - Humans MH - Infant, Newborn MH - Infant MH - *Infant Mortality/trends MH - *Kernicterus/mortality/prevention & control MH - Hyperbilirubinemia, Neonatal/mortality/therapy MH - Cost of Illness MH - Jaundice, Neonatal/mortality/therapy/epidemiology/economics MH - Global Burden of Disease MH - Female OTO - NOTNLM OT - Extreme hyperbilirubinemia OT - India OT - Infant mortality rate OT - Joinpoint analysis OT - Kernicterus OT - Value per statistical life COIS- Declarations Conflict of Interest None. EDAT- 2024/08/21 17:42 MHDA- 2024/11/18 12:32 CRDT- 2024/08/21 11:20 PHST- 2024/03/28 00:00 [received] PHST- 2024/07/25 00:00 [accepted] PHST- 2024/11/18 12:32 [medline] PHST- 2024/08/21 17:42 [pubmed] PHST- 2024/08/21 11:20 [entrez] AID - 10.1007/s12098-024-05227-6 [pii] AID - 10.1007/s12098-024-05227-6 [doi] PST - ppublish SO - Indian J Pediatr. 2024 Dec;91(12):1262-1267. doi: 10.1007/s12098-024-05227-6. Epub 2024 Aug 21. PMID- 29794779 OWN - NLM STAT- MEDLINE DCOM- 20180604 LR - 20241120 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 97 IP - 21 DP - 2018 May TI - Efficacy and safety of oral zinc sulfate in the prevention of chemotherapy-induced oral mucositis: Protocol for a meta-analysis of randomized controlled trials. PG - e10839 LID - 10.1097/MD.0000000000010839 [doi] LID - e10839 AB - BACKGROUND: Oral mucositis has been an extremely serious complication resulted from cytotoxic effects of the chemotherapy among cancer patients. Several randomized controlled trials investigated the efficacy of zinc sulfate in prevention of this morbid condition among cancer patients undergoing chemotherapy, however conclusive findings has not yet been generated. This systematic review will assess the efficacy and safety of oral zinc sulfate for chemotherapy-induced oral mucositis. METHODS: We will electronically search all potential citations in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to April 2018. The randomized controlled trials, which investigated the efficacy of oral zinc sulfate for chemotherapy-induced oral mucositis will be considered. We will assign 2 independent investigators to perform search, screen citations, extract data, and appraise risk of bias. And then, the primary investigator will adopt RevMan 5.3 software to complete all statistical analyses. ETHICS AND DISSEMINATION: The findings from this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication. Moreover, we will disseminate all results in any topic-related conference. REGISTRATION NUMBER: This protocol has been registered with a number of CRD42018093605. FAU - Tian, Xu AU - Tian X AD - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China. FAU - Chen, Wei-Qing AU - Chen WQ FAU - Liu, Xiao-Ling AU - Liu XL FAU - Pi, Yuan-Ping AU - Pi YP FAU - Chen, Hui AU - Chen H LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Antineoplastic Agents) RN - 0 (Astringents) RN - 7733-02-0 (Zinc Sulfate) SB - IM MH - Antineoplastic Agents/*adverse effects MH - Astringents/administration & dosage/therapeutic use MH - Humans MH - Neoplasms/complications/drug therapy MH - Randomized Controlled Trials as Topic MH - Stomatitis/*chemically induced/*drug therapy/prevention & control MH - Systematic Reviews as Topic MH - Zinc Sulfate/administration & dosage/*therapeutic use MH - Meta-Analysis as Topic PMC - PMC6392683 COIS- The authors declare no conflicts of interest. EDAT- 2018/05/26 06:00 MHDA- 2018/06/05 06:00 PMCR- 2018/05/25 CRDT- 2018/05/26 06:00 PHST- 2018/05/26 06:00 [entrez] PHST- 2018/05/26 06:00 [pubmed] PHST- 2018/06/05 06:00 [medline] PHST- 2018/05/25 00:00 [pmc-release] AID - 00005792-201805250-00055 [pii] AID - MD-D-18-02935 [pii] AID - 10.1097/MD.0000000000010839 [doi] PST - ppublish SO - Medicine (Baltimore). 2018 May;97(21):e10839. doi: 10.1097/MD.0000000000010839. PMID- 20812768 OWN - NLM STAT- MEDLINE DCOM- 20101210 LR - 20211020 IS - 1179-1942 (Electronic) IS - 0114-5916 (Linking) VI - 33 IP - 10 DP - 2010 Oct 1 TI - Cardiovascular effects of methylphenidate, amphetamines and atomoxetine in the treatment of attention-deficit hyperactivity disorder. PG - 821-42 LID - 10.2165/11536380-000000000-00000 [doi] AB - Attention-deficit hyperactivity disorder (ADHD) is a very common condition in children and often extends into the adult years. Drugs such as methylphenidate, amphetamines and atomoxetine are frequently prescribed as part of management. The use of these drugs has been increasing and significant clinical benefit is achieved but safety has been questioned. In this review, the cardiovascular safety of these drugs is examined with regard to effects on blood pressure (BP), heart rate (HR), ECG parameters and the risk of sudden death. Methylphenidate appears to cause minor increases in BP and HR. There are no strong data to suggest that methylphenidate increases the corrected QT interval (QTc). Amphetamines appear to cause minor increases in HR and BP over the long term. There is growing evidence to suggest that amphetamines do not cause statistically or clinically significant increases in QTc. Sudden death remains an extremely rare event and there is no clear evidence to attribute this to methylphenidate. Some data even suggest that the risk of sudden death in treated children may be less common than in the background population. Limited data suggest that atomoxetine may increase BP and HR in the short term; in the long term it appears to increase BP. The effects of atomoxetine on QTc remain uncertain. Use of this drug does not appear to be associated with sudden death. Because the current evidence is based on research that has not been specifically designed to investigate the cardiovascular effects of these drugs it is difficult to draw firm conclusions, and further work is required specifically to address these questions. FAU - Stiefel, Gary AU - Stiefel G AD - St Mary's Hospital, London, UK. FAU - Besag, Frank M C AU - Besag FM LA - eng PT - Journal Article PT - Review PL - New Zealand TA - Drug Saf JT - Drug safety JID - 9002928 RN - 0 (Adrenergic Uptake Inhibitors) RN - 0 (Amphetamines) RN - 0 (Central Nervous System Stimulants) RN - 0 (Propylamines) RN - 207ZZ9QZ49 (Methylphenidate) RN - 57WVB6I2W0 (Atomoxetine Hydrochloride) SB - IM MH - Adrenergic Uptake Inhibitors/adverse effects/therapeutic use MH - Amphetamines/*adverse effects/therapeutic use MH - Atomoxetine Hydrochloride MH - Attention Deficit Disorder with Hyperactivity/drug therapy MH - Blood Pressure/drug effects MH - Central Nervous System Stimulants/adverse effects/therapeutic use MH - Electrocardiography MH - Heart Rate/drug effects MH - Humans MH - Methylphenidate/*adverse effects/therapeutic use MH - Propylamines/*adverse effects/therapeutic use EDAT- 2010/09/04 06:00 MHDA- 2010/12/14 06:00 CRDT- 2010/09/04 06:00 PHST- 2010/09/04 06:00 [entrez] PHST- 2010/09/04 06:00 [pubmed] PHST- 2010/12/14 06:00 [medline] AID - 3 [pii] AID - 10.2165/11536380-000000000-00000 [doi] PST - ppublish SO - Drug Saf. 2010 Oct 1;33(10):821-42. doi: 10.2165/11536380-000000000-00000. PMID- 32113993 OWN - NLM STAT- MEDLINE DCOM- 20200713 LR - 20200713 IS - 1878-8769 (Electronic) IS - 1878-8750 (Linking) VI - 138 DP - 2020 Jun TI - Endoscopic Third Ventriculostomy in an Untreated Vein of Galen Malformation Presenting Lately with Acute Obstructive Hydrocephalus. PG - 35-38 LID - S1878-8750(20)30393-4 [pii] LID - 10.1016/j.wneu.2020.02.118 [doi] AB - BACKGROUND: Mural-type vein of Galen malformations (VoGMs) mostly manifest in later stages of infancy as macrocephaly, hydrocephalus, or failure to thrive unless previously diagnosed and treated. Literature is extremely limited on the success and safety of endoscopic third ventriculostomy (ETV) in acute obstructive hydrocephalus caused by an untreated VoGM. Thus, we aimed to present a case for demonstrating the possible efficacy and safety of ETV under such conditions. CASE DESCRIPTION: A 22-month-old boy presenting with acute-onset headache, vomiting, and lethargy was diagnosed with a mural-type VoGM and acute obstructive hydrocephalus. He was treated satisfactorily with ETV and endovascular embolization. We observed a shrinkage in malformation sac diameter of >20 mm in the magnetic resonance imaging angiography at postoperative year 1. The child showed normal motor and mental development at his outpatient clinic visit at postoperative month 15. CONCLUSIONS: To the best of our knowledge, this is the first case in the literature with an untreated VoGM presenting with acute obstructive hydrocephalus who was treated with the combination of ETV and endovascular embolization and had an adequate follow-up period. CI - Copyright © 2020 Elsevier Inc. All rights reserved. FAU - Sarica, Can AU - Sarica C AD - Department of Neurosurgery, Adiyaman University Education and Research Hospital, Adiyaman, Turkey. Electronic address: can.sarica@gmail.com. FAU - Erdogan, Onur AU - Erdogan O AD - Department of Neurosurgery, School of Medicine, Marmara University, Istanbul, Turkey. FAU - Sahin, Yener AU - Sahin Y AD - Department of Neurosurgery, School of Medicine, Marmara University, Istanbul, Turkey. FAU - Dagcinar, Adnan AU - Dagcinar A AD - Department of Neurosurgery, School of Medicine, Marmara University, Istanbul, Turkey. FAU - Baltacioglu, Feyyaz AU - Baltacioglu F AD - Department of Radiology, School of Medicine, Marmara University, Istanbul, Turkey. LA - eng PT - Case Reports PT - Journal Article DEP - 20200228 PL - United States TA - World Neurosurg JT - World neurosurgery JID - 101528275 SB - IM MH - Embolization, Therapeutic/methods MH - Humans MH - Hydrocephalus/etiology/*therapy MH - Infant MH - Male MH - Neuroendoscopy/*methods MH - Vein of Galen Malformations/etiology/*therapy MH - Ventriculostomy/*methods OTO - NOTNLM OT - Endoscopic third ventriculostomy OT - Endovascular treatment OT - Obstructive hydrocephalus OT - Vein of Galen malformations EDAT- 2020/03/03 06:00 MHDA- 2020/07/14 06:00 CRDT- 2020/03/02 06:00 PHST- 2020/02/02 00:00 [received] PHST- 2020/02/18 00:00 [revised] PHST- 2020/02/19 00:00 [accepted] PHST- 2020/03/03 06:00 [pubmed] PHST- 2020/07/14 06:00 [medline] PHST- 2020/03/02 06:00 [entrez] AID - S1878-8750(20)30393-4 [pii] AID - 10.1016/j.wneu.2020.02.118 [doi] PST - ppublish SO - World Neurosurg. 2020 Jun;138:35-38. doi: 10.1016/j.wneu.2020.02.118. Epub 2020 Feb 28. PMID- 37447669 OWN - NLM STAT- MEDLINE DCOM- 20230717 LR - 20230718 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 23 IP - 13 DP - 2023 Jun 22 TI - Research on Detection of Ultra-Low Concentration Anthrax Protective Antigen Using Graphene Field-Effect Transistor Biosensor. LID - 10.3390/s23135820 [doi] LID - 5820 AB - BACKGROUND: Protective antigen (PA) is an important biomarker for the early diagnosis of anthrax, and the accurate detection of protective antigen under extremely low concentration conditions has always been a hot topic in the biomedical field. To complete the diagnosis of anthrax in a timely manner, it is necessary to detect PA at extremely low concentrations, as the amount of PA produced in the early stage of anthrax invasion is relatively small. Graphene field-effect transistor (Gr-FET) biosensors are a new type of material for preparing biosensors, with the advantages of a short detection time and ultra-low detection limit. METHODS: The effect of different concentrations of diluents on the affinity of PA monoclonal antibodies was determined via an ELISA experiment. Combined with the Debye equation, 0.01 × PBS solution was finally selected as the diluent for the experiment. Then, a PA monoclonal antibody was selected as the bio-recognition element to construct a Gr-FET device based on CVD-grown graphene, which was used to detect the concentration of PA while recording the response time, linear range, detection limit, and other parameters. RESULTS: The experimental results showed that the biosensor could quickly detect PA, with a linear range of 10 fg/mL to 100 pg/mL and a detection limit of 10 fg/mL. In addition, the biosensor showed excellent specificity and repeatability. CONCLUSIONS: By constructing a Gr-FET device based on CVD-grown graphene and selecting a PA monoclonal antibody as the bio-recognition element, a highly sensitive, specific, and repeatable Gr-FET biosensor was successfully prepared for detecting extremely low concentrations of anthrax protective antigen (PA). This biosensor is expected to have a wide range of applications in clinical medicine and biological safety monitoring. FAU - Liang, Ting AU - Liang T AD - The Institute of NBC Defense PLA Army, Beijing 102205, China. FAU - Chen, Jingfei AU - Chen J AD - Unit No. 32169 of PLA, Nyingchi 860000, China. FAU - Yan, Rui AU - Yan R AD - The Institute of NBC Defense PLA Army, Beijing 102205, China. FAU - Jiang, Huaning AU - Jiang H AD - The Institute of NBC Defense PLA Army, Beijing 102205, China. AD - Unit No. 32281 of PLA, Chengdu 610200, China. FAU - Li, Hexi AU - Li H AD - The Institute of NBC Defense PLA Army, Beijing 102205, China. AD - Unit No. 31666 of PLA, Zhangye 610200, China. LA - eng PT - Journal Article DEP - 20230622 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 RN - 0 (anthrax toxin) RN - 7782-42-5 (Graphite) RN - 0 (Antibodies, Monoclonal) SB - IM MH - Humans MH - *Graphite MH - *Anthrax/diagnosis MH - *Biosensing Techniques/methods MH - Antibodies, Monoclonal MH - *Cardiovascular Diseases PMC - PMC10347003 OTO - NOTNLM OT - anthrax protective antigen OT - biosensor OT - graphene field-effect transistor COIS- The authors declare no conflict of interest. EDAT- 2023/07/14 13:06 MHDA- 2023/07/17 06:42 PMCR- 2023/06/22 CRDT- 2023/07/14 01:24 PHST- 2023/05/08 00:00 [received] PHST- 2023/05/28 00:00 [revised] PHST- 2023/06/01 00:00 [accepted] PHST- 2023/07/17 06:42 [medline] PHST- 2023/07/14 13:06 [pubmed] PHST- 2023/07/14 01:24 [entrez] PHST- 2023/06/22 00:00 [pmc-release] AID - s23135820 [pii] AID - sensors-23-05820 [pii] AID - 10.3390/s23135820 [doi] PST - epublish SO - Sensors (Basel). 2023 Jun 22;23(13):5820. doi: 10.3390/s23135820. PMID- 24411445 OWN - NLM STAT- MEDLINE DCOM- 20140909 LR - 20140113 IS - 1879-0909 (Electronic) IS - 0141-0229 (Linking) VI - 55 DP - 2014 Feb 5 TI - Production of citrinin-free Monascus pigments by submerged culture at low pH. PG - 50-7 LID - S0141-0229(13)00253-6 [pii] LID - 10.1016/j.enzmictec.2013.12.007 [doi] AB - Microbial fermentation of citrinin-free Monascus pigments is of great interest to meet the demand of food safety. In the present work, the effect of various nitrogen sources, such as monosodium glutamate (MSG), cornmeal, (NH4)₂SO₄, and NaNO₃, on Monascus fermentation was examined under different initial pH conditions. The composition of Monascus pigments and the final pH of fermentation broth after Monascus fermentation were determined. It was found that nitrogen source was directly related to the final pH and the final pH regulated the composition of Monascus pigments and the biosynthesis of citrinin. Thus, an ideal nitrogen source can be selected to control the final pH and then the citrinin biosynthesis. Citrinin-free orange pigments were produced at extremely low initial pH in the medium with (NH4)₂SO₄ or MSG as nitrogen source. No citrinin biosynthesis at extremely low pH was further confirmed by extractive fermentation of intracellular pigments in the nonionic surfactant Triton X-100 micelle aqueous solution. This is the first report about the production of citrinin-free Monascus pigments at extremely low pH. CI - Copyright © 2013 Elsevier Inc. All rights reserved. FAU - Kang, Biyu AU - Kang B AD - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, PR China. FAU - Zhang, Xuehong AU - Zhang X AD - State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, PR China. FAU - Wu, Zhenqiang AU - Wu Z AD - School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, PR China. FAU - Wang, Zhilong AU - Wang Z AD - School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address: zlwang@sjtu.edu.cn. FAU - Park, Sunghoon AU - Park S AD - Department of Chemical Engineering, Pusan National University, Pusan 609-735, South Korea. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131214 PL - United States TA - Enzyme Microb Technol JT - Enzyme and microbial technology JID - 8003761 RN - 0 (Culture Media) RN - 0 (Micelles) RN - 0 (Nitrates) RN - 0 (Pigments, Biological) RN - 0 (Solutions) RN - 3S697X6SNZ (Citrinin) RN - 8M4L3H2ZVZ (sodium nitrate) RN - 9002-93-1 (Octoxynol) RN - N762921K75 (Nitrogen) RN - SU46BAM238 (Ammonium Sulfate) RN - W81N5U6R6U (Sodium Glutamate) SB - IM MH - Ammonium Sulfate/metabolism MH - Chromatography, Thin Layer MH - Citrinin/analysis MH - Culture Media/pharmacology MH - Fermentation MH - Flour MH - Food Contamination/prevention & control MH - Hydrogen-Ion Concentration MH - Micelles MH - Monascus/growth & development/*metabolism MH - Mycology/*methods MH - Nitrates/metabolism MH - Nitrogen/metabolism MH - Octoxynol MH - Pigments, Biological/*biosynthesis/isolation & purification MH - Sodium Glutamate/metabolism MH - Solutions MH - Zea mays OTO - NOTNLM OT - Citrinin OT - Monascus pigments OT - Nitrogen source OT - Secondary metabolite OT - pH EDAT- 2014/01/15 06:00 MHDA- 2014/09/10 06:00 CRDT- 2014/01/14 06:00 PHST- 2013/11/05 00:00 [received] PHST- 2013/12/05 00:00 [revised] PHST- 2013/12/07 00:00 [accepted] PHST- 2014/01/14 06:00 [entrez] PHST- 2014/01/15 06:00 [pubmed] PHST- 2014/09/10 06:00 [medline] AID - S0141-0229(13)00253-6 [pii] AID - 10.1016/j.enzmictec.2013.12.007 [doi] PST - ppublish SO - Enzyme Microb Technol. 2014 Feb 5;55:50-7. doi: 10.1016/j.enzmictec.2013.12.007. Epub 2013 Dec 14. PMID- 11319578 OWN - NLM STAT- MEDLINE DCOM- 20010607 LR - 20191104 IS - 1075-2765 (Print) IS - 1075-2765 (Linking) VI - 7 IP - 2 DP - 2000 Mar TI - Therapeutic misadventure with paracetamol: fact or fiction? PG - 99-114 AB - As a consequence of its consistent safety profile and the low incidence of side effects, paracetamol is one of the most widely used analgesics, both in adults and children. However, paracetamol has the potential for hepatotoxicity, usually as a result of deliberate self-poisoning or, to a much lesser extent, accidental overdose. A variety of factors is thought to influence hepatotoxicity, including dose, concomitant use of microsome-inducing agents and other drugs, underlying disease, malnutrition, fasting, acute and chronic alcohol intake, ethnicity, and age. Unfortunately, none of these factors has been properly studied in humans. From a physiological standpoint, acute paracetamol hepatotoxicity at therapeutic doses is extremely unlikely despite reports of so-called therapeutic misadventure. It is clear that, in many of these cases, grossly excessive doses of paracetamol have been taken. Analyzing the various reports is difficult as the data are often incomplete. In summary, although hepatic toxicity is recognized in patients taking a major paracetamol overdose, the incidence of adverse events with its proper use is very low, particularly when considering with the enormous volume of drug use. Therapeutic misadventure is extremely uncommon and the facts are often misrepresented. FAU - Prescott, L F AU - Prescott LF AD - Clinical Pharmacology, University of Edinburgh, Edinburgh, Scotland, United Kingdom. LA - eng PT - Journal Article PT - Review PL - United States TA - Am J Ther JT - American journal of therapeutics JID - 9441347 RN - 0 (Analgesics, Non-Narcotic) RN - 362O9ITL9D (Acetaminophen) SB - IM MH - Acetaminophen/*adverse effects/poisoning MH - Adult MH - Analgesics, Non-Narcotic/*adverse effects MH - Child MH - Drug Overdose MH - Humans MH - Liver/*drug effects RF - 139 EDAT- 2001/04/25 10:00 MHDA- 2001/06/08 10:01 CRDT- 2001/04/25 10:00 PHST- 2001/04/25 10:00 [pubmed] PHST- 2001/06/08 10:01 [medline] PHST- 2001/04/25 10:00 [entrez] AID - 10.1097/00045391-200007020-00007 [doi] PST - ppublish SO - Am J Ther. 2000 Mar;7(2):99-114. doi: 10.1097/00045391-200007020-00007. PMID- 37801626 OWN - NLM STAT- MEDLINE DCOM- 20231102 LR - 20231102 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 55 IP - 2 DP - 2023 TI - Climate change, air quality, and respiratory health: a focus on particle deposition in the lungs. PG - 2264881 LID - 10.1080/07853890.2023.2264881 [doi] LID - 2264881 AB - This review article delves into the multifaceted relationship between climate change, air quality, and respiratory health, placing a special focus on the process of particle deposition in the lungs. We discuss the capability of climate change to intensify air pollution and alter particulate matter physicochemical properties such as size, dispersion, and chemical composition. These alterations play a significant role in influencing the deposition of particles in the lungs, leading to consequential respiratory health effects. The review paper provides a broad exploration of climate change's direct and indirect role in modifying particulate air pollution features and its interaction with other air pollutants, which may change the ability of particle deposition in the lungs. In conclusion, climate change may play an important role in regulating particle deposition in the lungs by changing physicochemistry of particulate air pollution, therefore, increasing the risk of respiratory disease development. FAU - Chang, Jer-Hwa AU - Chang JH AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Lee, Yueh-Lun AU - Lee YL AD - Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Chang, Li-Te AU - Chang LT AD - Department of Environmental Engineering and Science, Feng Chia University, Taichung, Taiwan. FAU - Chang, Ta-Yuan AU - Chang TY AD - Department of Occupational Safety and Health, College of Public Health, China Medical University, Taichung, Taiwan. FAU - Hsiao, Ta-Chih AU - Hsiao TC AD - Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan. FAU - Chung, Kian Fan AU - Chung KF AD - National Heart and Lung Institute, Imperial College London, London, UK. FAU - Ho, Kin Fai AU - Ho KF AD - JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, China. FAU - Kuo, Han-Pin AU - Kuo HP AD - Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Lee, Kang-Yun AU - Lee KY AD - Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. FAU - Chuang, Kai-Jen AU - Chuang KJ AD - School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Chuang, Hsiao-Chi AU - Chuang HC AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan. AD - Cell Physiology and Molecular Image Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20231006 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 0 (Air Pollutants) SB - IM MH - Humans MH - Climate Change MH - *Air Pollution/adverse effects/analysis MH - *Air Pollutants/adverse effects/analysis MH - Lung PMC - PMC10561567 OAB - Climate change influences particle deposition in the lungs by modifying the physicochemical properties of particulate air pollution, thereby escalating the risk of respiratory disease development.It is crucial for healthcare providers to educate patients about the relationship between climate change and respiratory health.People with conditions such as asthma, COPD, and allergies must understand how changes in weather, air pollution, and allergens can exacerbate their symptoms.Instruction on understanding air quality indices and pollen predictions, along with recommendations on adapting everyday activities and medication regimens in response, is essential. OABL- eng OTO - NOTNLM OT - Air pollution OT - COPD OT - asthma OT - children OT - extreme weather OT - secondary organic aerosol COIS- The authors declare that they have no conflicts of interest. No potential conflict of interest was reported by the author(s). EDAT- 2023/10/06 18:42 MHDA- 2023/11/02 12:45 PMCR- 2023/10/06 CRDT- 2023/10/06 15:02 PHST- 2023/11/02 12:45 [medline] PHST- 2023/10/06 18:42 [pubmed] PHST- 2023/10/06 15:02 [entrez] PHST- 2023/10/06 00:00 [pmc-release] AID - 2264881 [pii] AID - 10.1080/07853890.2023.2264881 [doi] PST - ppublish SO - Ann Med. 2023;55(2):2264881. doi: 10.1080/07853890.2023.2264881. Epub 2023 Oct 6. PMID- 15147249 OWN - NLM STAT- MEDLINE DCOM- 20040812 LR - 20220409 IS - 0017-8748 (Print) IS - 0017-8748 (Linking) VI - 44 IP - 5 DP - 2004 May TI - Consensus statement: cardiovascular safety profile of triptans (5-HT agonists) in the acute treatment of migraine. PG - 414-25 AB - BACKGROUND: Health care providers frequently cite concerns about cardiovascular safety of the triptans as a barrier to their use. In 2002, the American Headache Society convened the Triptan Cardiovascular Safety Expert Panel to evaluate the evidence on triptan-associated cardiovascular risk and to formulate consensus recommendations for making informed decisions for their use in patients with migraine. OBJECTIVE: To summarize the evidence reviewed by the Triptan Cardiovascular Safety Expert Panel and their recommendations for the use of triptans in clinical practice. PARTICIPANTS: The Triptan Cardiovascular Safety Expert Panel was composed of a multidisciplinary group of experts in neurology, primary care, cardiology, pharmacology, women's health, and epidemiology. EVIDENCE AND CONSENSUS PROCESS: An exhaustive search of the relevant published literature was reviewed by each panel member in preparation for an open roundtable meeting. Pertinent issues (eg, cardiovascular pharmacology of triptans, epidemiology of cardiovascular disease, cardiovascular risk assessment, migraine) were presented as a prelude to group discussion and formulation of consensus conclusions and recommendations. Follow-up meetings were held by telephone. CONCLUSIONS: (1) Most of the data on triptans are derived from patients without known coronary artery disease. (2) Chest symptoms occurring during use of triptans are generally nonserious and are not explained by ischemia. (3) The incidence of serious cardiovascular events with triptans in both clinical trials and clinical practice appears to be extremely low. (4) The cardiovascular risk-benefit profile of triptans favors their use in the absence of contraindications. FAU - Dodick, David AU - Dodick D AD - Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA. FAU - Lipton, Richard B AU - Lipton RB FAU - Martin, Vincent AU - Martin V FAU - Papademetriou, Vasilios AU - Papademetriou V FAU - Rosamond, Wayne AU - Rosamond W FAU - MaassenVanDenBrink, Antoinette AU - MaassenVanDenBrink A FAU - Loutfi, Hassan AU - Loutfi H FAU - Welch, K Michael AU - Welch KM FAU - Goadsby, Peter J AU - Goadsby PJ FAU - Hahn, Steven AU - Hahn S FAU - Hutchinson, Susan AU - Hutchinson S FAU - Matchar, David AU - Matchar D FAU - Silberstein, Stephen AU - Silberstein S FAU - Smith, Timothy R AU - Smith TR FAU - Purdy, R Allan AU - Purdy RA FAU - Saiers, Jane AU - Saiers J CN - Triptan Cardiovascular Safety Expert Panel LA - eng PT - Consensus Development Conference PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - United States TA - Headache JT - Headache JID - 2985091R RN - 0 (Serotonin Receptor Agonists) SB - IM MH - Acute Disease MH - Chest Pain/chemically induced MH - Coronary Disease/*chemically induced MH - Evidence-Based Medicine MH - Humans MH - Migraine Disorders/*drug therapy MH - Serotonin Receptor Agonists/*adverse effects/therapeutic use RF - 66 EDAT- 2004/05/19 05:00 MHDA- 2004/08/13 05:00 CRDT- 2004/05/19 05:00 PHST- 2004/05/19 05:00 [pubmed] PHST- 2004/08/13 05:00 [medline] PHST- 2004/05/19 05:00 [entrez] AID - HED04078 [pii] AID - 10.1111/j.1526-4610.2004.04078.x [doi] PST - ppublish SO - Headache. 2004 May;44(5):414-25. doi: 10.1111/j.1526-4610.2004.04078.x. PMID- 29630288 STAT- Publisher CTDT- 20220926 PB - StatPearls Publishing DP - 2025 Jan TI - EMS Provider Health And Wellness. BTI - StatPearls AB - Emergency medical services (EMS) workers may experience mental, physical, and emotional stress every shift. In addition to high levels of stress, they are experiencing increasing incidents of posttraumatic stress disorder (PTSD) and on-the-job injuries. These issues contribute to high rates of suicide, job-related burnout, clinical depression, and physical conditions, which can prevent EMS providers to continue working in the field. Personal health and physical, emotional, and mental wellness are critical in helping EMS workers survive in their careers. EMS workers are highly trained medical personnel who assist or work as an extension of a physician, usually in the prehospital setting. Modern-day EMS began after the National Research Council released its 1966 White paper titled Accidental Death and Disability: The Neglected Disease of Modern Society. It found that due to the high incidence of accidental death in the United States, public safety needed to include national, standardized, and advanced medical training. This paper was the impetus for the National Standard Paramedic Curriculum. In 2014, the United States (US) Department of Labor Bureau of Labor Statistics estimated 241,200 paramedic jobs, with a predicted 24% job growth rate over the following 8 years. Since its inception, EMS providers have long been known for their ability to help patients in the most extreme circumstances. This may happen in any setting, from the middle of a major interstate highway during the summer heat to the open farmlands in freezing temperatures to the highest-crime areas of cities. Along with dealing with difficult environments and high patient acuity, the release of catecholamines while driving "lights and sirens" has labeled many in the industry as "adrenaline junkies." These aspects of the job attract specific personality types to the EMS field. Dr. Jeffery Mitchell documented general personality traits of emergency personnel as: Need to be in control. Obsessive. Compulsive. Highly motivated by internal factors. Action-oriented. High need for stimulation. Need immediate gratification. Easily bored. Risk takers. Rescue personality. Highly dedicated. Strong demand to be needed. Mitchell stated that these traits make EMS workers continue to work, even in the face of harm to themselves. In addition to the mental and emotional toll the industry can take on the provider, it is not uncommon to go from deep sleep to moving a 300-pound (136 kg) patient 15 minutes later. There is no time for stretching or warming the muscles before they are stressed. Furthermore, until recently, most EMS agencies worked 24-hour shifts for their employees. In addition to low wages and the need for multiple jobs, this schedule was a significant reason for the sleep debt providers incurred. Sleep debt is the difference between the amount the EMS provider can obtain and the amount of sleep the EMS provider requires not to feel severely tired. Over one-half of all EMS workers report inadequate sleep, poor sleep quality, and/or poor recovery between shifts. CI - Copyright © 2025, StatPearls Publishing LLC. FAU - Mountfort, Steven AU - Mountfort S AD - Aims Community College FAU - Wilson, Jess AU - Wilson J AD - UTHSCSA LA - eng PT - Study Guide PT - Book Chapter PL - Treasure Island (FL) COIS- Disclosure: Steven Mountfort declares no relevant financial relationships with ineligible companies. Disclosure: Jess Wilson declares no relevant financial relationships with ineligible companies. EDAT- 2022/09/26 00:00 CRDT- 2022/09/26 00:00 AID - NBK493236 [bookaccession] PMID- 34904434 OWN - NLM STAT- MEDLINE DCOM- 20220317 LR - 20220317 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 13 IP - 51 DP - 2021 Dec 29 TI - A pH-Responsive Persistent Luminescence Nanozyme for Selective Imaging and Killing of Helicobacter pylori and Common Resistant Bacteria. PG - 60955-60965 LID - 10.1021/acsami.1c21318 [doi] AB - Helicobacter pylori (H. pylori) infection is implicated in the etiology of many diseases. H. pylori eradication by antibiotic therapy is limited by the extreme acidic environment in the stomach, the undesired side effect of intestinal commensal bacteria, and the development of drug resistance. Here, we report a pH-responsive persistent luminescence (PL) nanozyme (MSPLNP-Au-CB) for in vivo imaging and inactivation of H. pylori. This PL nanozyme is composed of mesoporous silica (MS)-coated persistent luminescence nanoparticles (MSPLNP), Au nanoparticles (AuNP), and chitosan-benzeneboronic acid (CB), taking advantage of the long PL of PLNP to realize autofluorescence-free imaging, the pH-activated oxidase- and peroxidase-like nanozyme activity of AuNP, and the bacterial binding capacity of CB. The MSPLNP-Au-CB nanozyme can resist the corrosion of gastric acid and exhibit pH-activated dual nanozyme activity to catalyze bactericidal reactive oxygen species generation. This multifunctional nanozyme enables targeted imaging and activated deactivation of H. pylori under extreme gastric acid conditions as well as methicillin-resistant Staphylococcus aureus in common slightly acidic environments, while it has no side effects on the commensal bacteria and normal cells in normal physiological environments. This work provides a promising PL nanozyme platform for bioimaging and therapy of bacterial infection under harsh conditions. FAU - Yan, Li-Xia AU - Yan LX AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. AD - Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Wang, Bei-Bei AU - Wang BB AUID- ORCID: 0000-0002-6139-9495 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. AD - Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Zhao, Xu AU - Zhao X AUID- ORCID: 0000-0001-8000-9045 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. AD - Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Chen, Li-Jian AU - Chen LJ AUID- ORCID: 0000-0001-8671-8766 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. AD - Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Yan, Xiu-Ping AU - Yan XP AUID- ORCID: 0000-0001-9953-7681 AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China. AD - Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China. LA - eng PT - Journal Article DEP - 20211214 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 RN - 0 (Anti-Bacterial Agents) RN - 0 (Biocompatible Materials) RN - 7440-57-5 (Gold) SB - IM MH - Animals MH - Anti-Bacterial Agents/chemical synthesis/chemistry/*pharmacology MH - Biocompatible Materials/chemical synthesis/chemistry/*pharmacology MH - Gold/chemistry/*pharmacology MH - Helicobacter Infections/diagnostic imaging/drug therapy MH - Helicobacter pylori/*drug effects MH - Hydrogen-Ion Concentration MH - Materials Testing MH - Metal Nanoparticles/*chemistry MH - Methicillin-Resistant Staphylococcus aureus/*drug effects MH - Mice MH - Microbial Sensitivity Tests MH - Optical Imaging MH - Particle Size MH - Staphylococcal Infections/diagnostic imaging/drug therapy OTO - NOTNLM OT - Helicobacter pylori OT - antibacterial effect OT - nanozyme OT - pH-responsive OT - persistent luminescence EDAT- 2021/12/15 06:00 MHDA- 2022/03/18 06:00 CRDT- 2021/12/14 09:24 PHST- 2021/12/15 06:00 [pubmed] PHST- 2022/03/18 06:00 [medline] PHST- 2021/12/14 09:24 [entrez] AID - 10.1021/acsami.1c21318 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2021 Dec 29;13(51):60955-60965. doi: 10.1021/acsami.1c21318. Epub 2021 Dec 14. PMID- 29710823 OWN - NLM STAT- MEDLINE DCOM- 20190319 LR - 20240318 IS - 2072-6651 (Electronic) IS - 2072-6651 (Linking) VI - 10 IP - 5 DP - 2018 Apr 29 TI - Nanobody Technology for Mycotoxin Detection in the Field of Food Safety: Current Status and Prospects. LID - 10.3390/toxins10050180 [doi] LID - 180 AB - Mycotoxins, which are toxic, carcinogenic, and/or teratogenic, have posed a threat to food safety and public health. Sensitive and effective determination technologies for mycotoxin surveillance are required. Immunoassays have been regarded as useful supplements to chromatographic techniques. However, conventional antibodies involved in immunoassays are difficult to be expressed recombinantly and are susceptible to harsh environments. Nanobodies (or VHH antibodies) are antigen-binding sites of the heavy-chain antibodies produced from Camelidae. They are found to be expressed easily in prokaryotic or eukaryotic expression systems, more robust in extreme conditions, and facile to be used as surrogates for artificial antigens. These properties make them the promising and environmentally friendly immunoreagents in the next generation of immunoassays. This review briefly describes the latest developments in the area of nanobodies used in mycotoxin detection. Moreover, by integrating the introduction of the principle of nanobodies production and the critical assessment of their performance, this paper also proposes the prospect of nanobodies in the field of food safety in the foreseeable future. FAU - He, Ting AU - He T AD - State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. ht210@wipm.ac.cn. FAU - Zhu, Jiang AU - Zhu J AD - State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. jiangzhu@wipm.ac.cn. FAU - Nie, Yao AU - Nie Y AD - State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. nieyao@wipm.ac.cn. FAU - Hu, Rui AU - Hu R AD - State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. hurui@wipm.ac.cn. FAU - Wang, Ting AU - Wang T AD - Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062, China. wangting963@163.com. FAU - Li, Peiwu AU - Li P AD - Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062, China. peiwuli@oilcrops.cn. FAU - Zhang, Qi AU - Zhang Q AD - Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062, China. zhangqi01@caas.cn. FAU - Yang, Yunhuang AU - Yang Y AD - State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China. yang_yh@wipm.ac.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20180429 PL - Switzerland TA - Toxins (Basel) JT - Toxins JID - 101530765 RN - 0 (Mycotoxins) RN - 0 (Single-Domain Antibodies) SB - IM MH - Food Safety MH - Immunoassay MH - Mycotoxins/*analysis/immunology MH - Single-Domain Antibodies/*immunology PMC - PMC5983236 OTO - NOTNLM OT - Food safety OT - Immunoassay OT - Mycotoxins OT - Nanobody COIS- All authors declare no conflict of interest. EDAT- 2018/05/02 06:00 MHDA- 2019/03/20 06:00 PMCR- 2018/05/01 CRDT- 2018/05/02 06:00 PHST- 2018/04/10 00:00 [received] PHST- 2018/04/24 00:00 [revised] PHST- 2018/04/27 00:00 [accepted] PHST- 2018/05/02 06:00 [entrez] PHST- 2018/05/02 06:00 [pubmed] PHST- 2019/03/20 06:00 [medline] PHST- 2018/05/01 00:00 [pmc-release] AID - toxins10050180 [pii] AID - toxins-10-00180 [pii] AID - 10.3390/toxins10050180 [doi] PST - epublish SO - Toxins (Basel). 2018 Apr 29;10(5):180. doi: 10.3390/toxins10050180. PMID- 37681745 OWN - NLM STAT- MEDLINE DCOM- 20231122 LR - 20240227 IS - 1460-2431 (Electronic) IS - 0022-0957 (Linking) VI - 74 IP - 21 DP - 2023 Nov 21 TI - Drought survival in conifer species is related to the time required to cross the stomatal safety margin. PG - 6847-6859 LID - 10.1093/jxb/erad352 [doi] AB - The regulation of water loss and the spread of xylem embolism have mostly been considered separately. The development of an integrated approach taking into account the temporal dynamics and relative contributions of these mechanisms to plant drought responses is urgently needed. Do conifer species native to mesic and xeric environments display different hydraulic strategies and temporal sequences under drought? A dry-down experiment was performed on seedlings of four conifer species differing in embolism resistance, from drought-sensitive to extremely drought-resistant species. A set of traits related to drought survival was measured, including turgor loss point, stomatal closure, minimum leaf conductance, and xylem embolism resistance. All species reached full stomatal closure before the onset of embolism, with all but the most drought-sensitive species presenting large stomatal safety margins, demonstrating that highly drought-resistant species do not keep their stomata open under drought conditions. Plant dry-down time to death was significantly influenced by the xylem embolism threshold, stomatal safety margin, and minimum leaf conductance, and was best explained by the newly introduced stomatal margin retention index (SMRIΨ50) which reflects the time required to cross the stomatal safety margin. The SMRIΨ50 may become a key tool for the characterization of interspecific drought survival variability in trees. CI - © The Author(s) 2023. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - Petek-Petrik, Anja AU - Petek-Petrik A AD - Department of Vegetation Ecology, Institute of Botany, Academy of Sciences of the Czech Republic, Brno, Czech Republic. FAU - Petrík, Peter AU - Petrík P AD - Karlsruhe Institute of Technology (KIT), Institute of Meteorology and Climate Research-Atmospheric Environmental Research (IMK-IFU), 82467 Garmisch-Partenkirchen, Germany. FAU - Lamarque, Laurent J AU - Lamarque LJ AUID- ORCID: 0000-0002-1430-5193 AD - BIOGECO, University of Bordeaux, INRAE, F-33615 Pessac, France. AD - Département des Sciences de l'Environnement, UQTR, Trois-Rivières, Québec, Canada. FAU - Cochard, Hervé AU - Cochard H AD - PIAF, University of Clermont Auvergne, INRAE, 63000 Clermont-Ferrand, France. FAU - Burlett, Régis AU - Burlett R AD - BIOGECO, University of Bordeaux, INRAE, F-33615 Pessac, France. FAU - Delzon, Sylvain AU - Delzon S AUID- ORCID: 0000-0003-3442-1711 AD - BIOGECO, University of Bordeaux, INRAE, F-33615 Pessac, France. LA - eng GR - INTERREG SUDOE/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Exp Bot JT - Journal of experimental botany JID - 9882906 RN - 059QF0KO0R (Water) SB - IM MH - Plant Stomata/physiology MH - *Tracheophyta MH - Droughts MH - Plant Transpiration/physiology MH - Plant Leaves/physiology MH - Water/physiology MH - Trees/physiology MH - Xylem/physiology MH - *Embolism OTO - NOTNLM OT - Drought tolerance OT - embolism resistance OT - residual transpiration OT - stomatal closure OT - stomatal safety margin OT - tree mortality EDAT- 2023/09/08 12:42 MHDA- 2023/11/22 06:42 CRDT- 2023/09/08 08:43 PHST- 2023/03/05 00:00 [received] PHST- 2023/09/07 00:00 [accepted] PHST- 2023/11/22 06:42 [medline] PHST- 2023/09/08 12:42 [pubmed] PHST- 2023/09/08 08:43 [entrez] AID - 7264137 [pii] AID - 10.1093/jxb/erad352 [doi] PST - ppublish SO - J Exp Bot. 2023 Nov 21;74(21):6847-6859. doi: 10.1093/jxb/erad352. PMID- 22494060 OWN - NLM STAT- MEDLINE DCOM- 20130418 LR - 20141120 IS - 1556-9535 (Electronic) IS - 1556-9527 (Linking) VI - 31 IP - 4 DP - 2012 Dec TI - An in vitro method for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing. PG - 292-305 LID - 10.3109/15569527.2012.667031 [doi] AB - Chemical sensitization is a serious condition caused by small reactive molecules and is characterized by a delayed type hypersensitivity known as allergic contact dermatitis (ACD). Contact with these molecules via dermal exposure represent a significant concern for chemical manufacturers. Recent legislation in the EU has created the need to develop non-animal alternative methods for many routine safety studies including sensitization. Although most of the alternative research has focused on pure chemicals that possess reasonable solubility properties, it is important for any successful in vitro method to have the ability to test compounds with low aqueous solubility. This is especially true for the medical device industry where device extracts must be prepared in both polar and non-polar vehicles in order to evaluate chemical sensitization. The aim of this research was to demonstrate the functionality and applicability of the human reconstituted skin models (MatTek Epiderm(®) and SkinEthic RHE) as a test system for the evaluation of chemical sensitization and its potential use for medical device testing. In addition, the development of the human 3D skin model should allow the in vitro sensitization assay to be used for finished product testing in the personal care, cosmetics, and pharmaceutical industries. This approach combines solubility, chemical reactivity, cytotoxicity, and activation of the Nrf2/ARE expression pathway to identify and categorize chemical sensitizers. Known chemical sensitizers representing extreme/strong-, moderate-, weak-, and non-sensitizing potency categories were first evaluated in the skin models at six exposure concentrations ranging from 0.1 to 2500 µM for 24 h. The expression of eight Nrf2/ARE, one AhR/XRE and two Nrf1/MRE controlled gene were measured by qRT-PCR. The fold-induction at each exposure concentration was combined with reactivity and cytotoxicity data to determine the sensitization potential. The results demonstrated that both the MatTek and SkinEthic models performed in a manner consistent with data previously reported with the human keratinocyte (HaCaT) cell line. The system was tested further by evaluating chemicals known to be associated with the manufacture of medical devices. In all cases, the human skin models performed as well or better than the HaCaT cell model previously evaluated. In addition, this study identifies a clear unifying trigger that controls both the Nrf2/ARE pathway and essential biochemical events required for the development of ACD. Finally, this study has demonstrated that by utilizing human reconstructed skin models, it is possible to evaluate non-polar extracts from medical devices and low solubility finished products. FAU - McKim, James M Jr AU - McKim JM Jr AD - CeeTox, Inc, Kalamazoo, MI 49008, USA. jmckim@ceetox.com FAU - Keller, Donald J 3rd AU - Keller DJ 3rd FAU - Gorski, Joel R AU - Gorski JR LA - eng PT - Comparative Study PT - Journal Article DEP - 20120412 PL - England TA - Cutan Ocul Toxicol JT - Cutaneous and ocular toxicology JID - 101266892 RN - 0 (Allergens) RN - 0 (Cosmetics) SB - IM MH - Allergens/*toxicity MH - Animal Testing Alternatives MH - Cell Line MH - Cell Survival/drug effects MH - Consumer Product Safety MH - Cosmetics/*toxicity MH - Dermatitis, Allergic Contact/*etiology MH - Equipment Safety MH - Gene Expression Regulation/drug effects MH - Humans MH - In Vitro Techniques MH - Oxidative Stress/drug effects MH - Skin/*drug effects MH - Toxicity Tests/methods EDAT- 2012/04/13 06:00 MHDA- 2013/04/20 06:00 CRDT- 2012/04/13 06:00 PHST- 2012/04/13 06:00 [entrez] PHST- 2012/04/13 06:00 [pubmed] PHST- 2013/04/20 06:00 [medline] AID - 10.3109/15569527.2012.667031 [doi] PST - ppublish SO - Cutan Ocul Toxicol. 2012 Dec;31(4):292-305. doi: 10.3109/15569527.2012.667031. Epub 2012 Apr 12. PMID- 30280235 OWN - NLM STAT- MEDLINE DCOM- 20190909 LR - 20190909 IS - 1433-0431 (Electronic) IS - 0085-4530 (Linking) VI - 47 IP - 11 DP - 2018 Nov TI - [Biologics and further new drugs for rheumatic diseases since 2000]. PG - 906-911 LID - 10.1007/s00132-018-3650-4 [doi] AB - BACKGROUND: Rheumatoid arthritis (RA), psoriatic arthritis and axial spondyloarthritis are severe diseases, which without adequate treatment lead to extremely reduced mobility, functional status and quality of life. OBJECTIVE: The effects of biologics and further new antirheumatic drugs on the burden of disease. METHODS: Evaluation of study results and register data dealing with the efficacy and safety of these drugs. RESULTS: Biologics have been proven to dramatically improve the outcome of all three diseases and contributed to the fact that remission is a realistic target today. In addition, the cardiovascular risk and mortality in RA have been reduced and structural damage is considerably blocked by biologics. Recently Janus kinase (JAK) inhibitors contributed to the treatment possibilities in the same way. Biologics as well as JAK inhibitors offer an excellent safety profile and tolerability with infections being the most important risk. CONCLUSION: With the availability of biologics and additional new drugs all three diseases have lost the status of difficult to treat diseases. Their usage according to the guidelines ensures that the burden of disease can been minimalized in most cases. The benefit-risk profile of these drugs has been shown to be excellent. FAU - Krüger, K AU - Krüger K AD - Rheumatologisches Praxiszentrum, St. Bonifatius Str. 5, 81541, München, Deutschland. Klaus.krueger@med.uni-muenchen.de. LA - ger PT - Journal Article PT - Review TT - Biologika und weitere neue Medikamente in der Rheumatologie seit 2000. PL - Germany TA - Orthopade JT - Der Orthopade JID - 0331266 RN - 0 (Antirheumatic Agents) RN - 0 (Biological Products) SB - IM MH - *Antirheumatic Agents/therapeutic use MH - *Biological Products/therapeutic use MH - Humans MH - Quality of Life MH - *Rheumatic Diseases/drug therapy OTO - NOTNLM OT - Ankylosing spondyloarthritis OT - Disease-modifying antirheumatic drugs OT - JAK inhibitors OT - Psoriatic arthritis OT - Rheumatoid arthritis EDAT- 2018/10/04 06:00 MHDA- 2019/09/10 06:00 CRDT- 2018/10/04 06:00 PHST- 2018/10/04 06:00 [pubmed] PHST- 2019/09/10 06:00 [medline] PHST- 2018/10/04 06:00 [entrez] AID - 10.1007/s00132-018-3650-4 [pii] AID - 10.1007/s00132-018-3650-4 [doi] PST - ppublish SO - Orthopade. 2018 Nov;47(11):906-911. doi: 10.1007/s00132-018-3650-4. PMID- 34093781 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240810 IS - 1831-4732 (Electronic) IS - 1831-4732 (Linking) VI - 19 IP - 5 DP - 2021 May TI - Assessment of the feed additive consisting of dimethylglycine sodium salt (Taminizer D) for chickens for fattening for the renewal of its authorisation (Taminco N.V.). PG - e06621 LID - 10.2903/j.efsa.2021.6621 [doi] LID - e06621 AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of the feed additive consisting of dimethylglycine sodium salt (trade name: Taminizer D) as a zootechnical additive for chickens for fattening. In 2011, the FEEDAP Panel delivered an opinion on the safety and efficacy of the additive, and subsequently, the additive was authorised in the EU. In 2018, a second scientific assessment was made based on a dossier submitted for the modification of the terms of authorisation of the additive. The additive is authorised as 'dimethylglycine sodium salt with a purity of at least 97%' for chickens for fattening under the category 'zootechnical additives' and functional group 'other zootechnical additives (improvement of zootechnical parameters)'. The evidence provided by the applicant indicated that the additive currently in the market, produced by the two manufacturing routes, complies with the conditions of authorisation. No new evidence was found that would make the FEEDAP Panel reconsidering its previous conclusions in the safety for target species, consumers and environment. The FEEDAP Panel concludes that Taminizer D is not a skin irritant but may be an eye irritant and a skin sensitiser; although uncertainty remains on the presence of formaldehyde, exposure is considered extremely low. There is no need to assess the efficacy of the additive in the context of the renewal of the authorisation. CI - © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. CN - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) FAU - Bampidis, Vasileios AU - Bampidis V FAU - Azimonti, Giovanna AU - Azimonti G FAU - Bastos, Maria de Lourdes AU - Bastos ML FAU - Christensen, Henrik AU - Christensen H FAU - Dusemund, Birgit AU - Dusemund B FAU - Fašmon Durjava, Mojca AU - Fašmon Durjava M FAU - Kouba, Maryline AU - Kouba M FAU - López-Alonso, Marta AU - López-Alonso M FAU - López Puente, Secundino AU - López Puente S FAU - Marcon, Francesca AU - Marcon F FAU - Mayo, Baltasar AU - Mayo B FAU - Pechová, Alena AU - Pechová A FAU - Petkova, Mariana AU - Petkova M FAU - Ramos, Fernando AU - Ramos F FAU - Sanz, Yolanda AU - Sanz Y FAU - Villa, Roberto Edoardo AU - Villa RE FAU - Woutersen, Ruud AU - Woutersen R FAU - Brozzi, Rosella AU - Brozzi R FAU - Galobart, Jaume AU - Galobart J FAU - Gregoretti, Lucilla AU - Gregoretti L FAU - Innocenti, Matteo L AU - Innocenti ML FAU - Vettori, Maria Vittoria AU - Vettori MV FAU - López-Gálvez, Gloria AU - López-Gálvez G LA - eng PT - Journal Article DEP - 20210525 PL - United States TA - EFSA J JT - EFSA journal. European Food Safety Authority JID - 101642076 PMC - PMC8145268 OTO - NOTNLM OT - Taminizer D OT - chickens for fattening OT - dimethylglycine sodium salt OT - other zootechnical additives OT - renewal OT - safety OT - zootechnical additive EDAT- 2021/06/08 06:00 MHDA- 2021/06/08 06:01 PMCR- 2021/05/25 CRDT- 2021/06/07 05:52 PHST- 2021/06/07 05:52 [entrez] PHST- 2021/06/08 06:00 [pubmed] PHST- 2021/06/08 06:01 [medline] PHST- 2021/05/25 00:00 [pmc-release] AID - EFS26621 [pii] AID - 10.2903/j.efsa.2021.6621 [doi] PST - epublish SO - EFSA J. 2021 May 25;19(5):e06621. doi: 10.2903/j.efsa.2021.6621. eCollection 2021 May. PMID- 39201103 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240901 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 13 IP - 16 DP - 2024 Aug 22 TI - Effects of Environmental Conditions on Athlete's Cardiovascular System. LID - 10.3390/jcm13164961 [doi] LID - 4961 AB - Environmental factors such as extreme temperatures, humidity, wind, pollution, altitude, and diving can significantly impact athletes' cardiovascular systems, potentially hindering their performance, particularly in outdoor sports. The urgency of this issue is heightened by the increasing prevalence of climate change and its associated conditions, including fluctuating pollution levels, temperature variations, and the spread of infectious diseases. Despite its critical importance, this topic is often overlooked in sports medicine. This narrative review seeks to address this gap by providing a comprehensive, evidence-based evaluation of how athletes respond to environmental stresses. A thorough assessment of current knowledge is essential to better prepare athletes for competition under environmental stress and to minimize the harmful effects of these factors. Specifically, adaptative strategies and preventative measures are vital to mitigating these environmental influences and ensuring athletes' safety. FAU - Segreti, Andrea AU - Segreti A AUID- ORCID: 0000-0003-2631-8642 AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 15, 00135 Roma, Italy. FAU - Celeski, Mihail AU - Celeski M AUID- ORCID: 0000-0002-6374-1821 AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Guerra, Emiliano AU - Guerra E AUID- ORCID: 0000-0002-3021-9463 AD - Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41124 Modena, Italy. FAU - Crispino, Simone Pasquale AU - Crispino SP AUID- ORCID: 0000-0002-0051-5253 AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Vespasiano, Francesca AU - Vespasiano F AUID- ORCID: 0009-0003-2021-9261 AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Buzzelli, Lorenzo AU - Buzzelli L AUID- ORCID: 0009-0004-5621-9316 AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. FAU - Fossati, Chiara AU - Fossati C AUID- ORCID: 0000-0002-2870-7185 AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 15, 00135 Roma, Italy. FAU - Papalia, Rocco AU - Papalia R AD - Department of Orthopaedic and Trauma Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. FAU - Pigozzi, Fabio AU - Pigozzi F AUID- ORCID: 0000-0001-5808-9405 AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Piazza Lauro de Bosis, 15, 00135 Roma, Italy. FAU - Grigioni, Francesco AU - Grigioni F AD - Cardiology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy. AD - Research Unit of Cardiovascular Science, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy. LA - eng PT - Journal Article PT - Review DEP - 20240822 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC11355938 OTO - NOTNLM OT - adaptation OT - athletes OT - cardiovascular efficiency OT - environmental conditions COIS- The authors declare no conflicts of interest. EDAT- 2024/08/31 09:44 MHDA- 2024/08/31 09:45 PMCR- 2024/08/22 CRDT- 2024/08/29 01:11 PHST- 2024/05/25 00:00 [received] PHST- 2024/08/13 00:00 [revised] PHST- 2024/08/17 00:00 [accepted] PHST- 2024/08/31 09:45 [medline] PHST- 2024/08/31 09:44 [pubmed] PHST- 2024/08/29 01:11 [entrez] PHST- 2024/08/22 00:00 [pmc-release] AID - jcm13164961 [pii] AID - jcm-13-04961 [pii] AID - 10.3390/jcm13164961 [doi] PST - epublish SO - J Clin Med. 2024 Aug 22;13(16):4961. doi: 10.3390/jcm13164961. PMID- 19732532 OWN - NLM STAT- MEDLINE DCOM- 20090918 LR - 20090907 IS - 1603-6824 (Electronic) IS - 0041-5782 (Linking) VI - 171 IP - 35 DP - 2009 Aug 24 TI - [Optical coherence tomography for coronary visualisation]. PG - 2466-7 AB - Optical coherence tomography (OCT) is a novel intracoronary imaging technique with an extremely high resolution, which is superior to any current modality in visualising the coronary anatomy. Clinical applicability includes 1) the study of vulnerable plaques and evaluation of the effect of medical and interventional treatment here on, 2) guidance of coronary interventions and study of the clinical importance of intervention-related pathology, and 3) evaluation of long-term safety of coronary stents. Drawbacks include the need to interrupt blood flow and a limited tissue penetration. FAU - Radu, Maria D AU - Radu MD AD - Cardiologisk Laboratorium 2013, Rigshospitalet, DK-2100 København Ø. maria_d_radu@yahoo.com FAU - Jørgensen, Erik AU - Jørgensen E FAU - Saunamäki, Kari AU - Saunamäki K LA - dan PT - English Abstract PT - Journal Article TT - Optisk kohaerenstomografi til intrakoronar billeddannelse. PL - Denmark TA - Ugeskr Laeger JT - Ugeskrift for laeger JID - 0141730 SB - IM MH - Cardiac Surgical Procedures MH - Coronary Artery Disease/diagnosis/pathology MH - Coronary Disease/*diagnosis/pathology MH - Drug-Eluting Stents MH - Humans MH - Sensitivity and Specificity MH - *Tomography, Optical Coherence/adverse effects/methods EDAT- 2009/09/08 06:00 MHDA- 2009/09/19 06:00 CRDT- 2009/09/08 06:00 PHST- 2009/09/08 06:00 [entrez] PHST- 2009/09/08 06:00 [pubmed] PHST- 2009/09/19 06:00 [medline] AID - VP06080290 [pii] PST - ppublish SO - Ugeskr Laeger. 2009 Aug 24;171(35):2466-7. PMID- 28060333 OWN - NLM STAT- MEDLINE DCOM- 20170817 LR - 20181202 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 118 DP - 2016 Dec 8 TI - Mesenchymal Stromal Cell Culture and Delivery in Autologous Conditions: A Smart Approach for Orthopedic Applications. LID - 10.3791/54845 [doi] LID - 54845 AB - Human Mesenchymal Stromal Cells (hMSCs) are cultured in vitro with different media. Limits on their use in clinical settings, however, mainly depend on potential biohazard and inflammation risks exerted by xenogeneic nutrients for their culture. Human derivatives or recombinant materials are the first choice candidates to reduce these reactions. Therefore, culture supplements and materials of autologous origin represent the best nutrients and the safest products. Here, we describe a new protocol for the isolation and culture of bone marrow hMSCs in autologous conditions - namely, patient-derived serum as a supplement for the culture medium and fibrin as a scaffold for hMSC administration. Indeed, hMSC/fibrin clot constructs could be extremely useful for several clinical applications. In particular, we focus on their use in orthopedic surgery, where the fibrin clot derived from the donor's own blood allowed effective cell delivery and nutrient/waste exchanges. To ensure optimal safety conditions, it is of the utmost importance to avoid the risks of hMSC transformation and tissue overgrowth. For these reasons, the approach described in this paper also indicates a minimally ex vivo hMSC expansion, to reduce cell senescence and morphologic changes, and short-term osteo-differentiation before implantation, to induce osteogenic lineage specification, thus decreasing the risk of subsequent uncontrolled proliferation. FAU - Trombi, Luisa AU - Trombi L AD - Dept. of Clinical and Experimental Medicine, University of Pisa; OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP); l.trombi@yahoo.it. FAU - Danti, Serena AU - Danti S AD - OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP); Dept. of Civil and Industrial Engineering, University of Pisa. FAU - Savelli, Sara AU - Savelli S AD - Immunohematology Operative Unit, Azienda Ospedaliero-Universitaria Pisana (AOUP). FAU - Moscato, Stefania AU - Moscato S AD - Dept. of Clinical and Experimental Medicine, University of Pisa. FAU - D'Alessandro, Delfo AU - D'Alessandro D AD - OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP); Dept. Of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa. FAU - Ricci, Claudio AU - Ricci C AD - OtoLab, Azienda Ospedaliero-Universitaria Pisana (AOUP). FAU - Giannotti, Stefano AU - Giannotti S AD - II Orthopedic and Traumatologic Clinic, Azienda Ospedaliero-Universitaria Pisana (AOUP). FAU - Petrini, Mario AU - Petrini M AD - Dept. of Clinical and Experimental Medicine, University of Pisa. LA - eng PT - Journal Article PT - Video-Audio Media DEP - 20161208 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 RN - 0 (Culture Media) RN - 9001-31-4 (Fibrin) SB - IM MH - *Cell Culture Techniques MH - Cell Differentiation MH - Cell Proliferation MH - Cells, Cultured MH - Culture Media MH - Fibrin/chemistry MH - Humans MH - *Mesenchymal Stem Cell Transplantation MH - Mesenchymal Stem Cells/*cytology MH - Osteogenesis MH - Serum/chemistry MH - Tissue Scaffolds PMC - PMC5226380 EDAT- 2017/01/07 06:00 MHDA- 2017/08/18 06:00 PMCR- 2016/12/08 CRDT- 2017/01/07 06:00 PHST- 2017/01/07 06:00 [entrez] PHST- 2017/01/07 06:00 [pubmed] PHST- 2017/08/18 06:00 [medline] PHST- 2016/12/08 00:00 [pmc-release] AID - 54845 [pii] AID - 10.3791/54845 [doi] PST - epublish SO - J Vis Exp. 2016 Dec 8;(118):54845. doi: 10.3791/54845. PMID- 34286517 OWN - NLM STAT- MEDLINE DCOM- 20210831 LR - 20210831 IS - 1899-5276 (Print) IS - 1899-5276 (Linking) VI - 30 IP - 8 DP - 2021 Aug TI - Cancer patients and internal medicine patients attitude towards COVID-19 vaccination in Poland. PG - 805-811 LID - 10.17219/acem/138962 [doi] AB - BACKGROUND: The initial approval of the Pfizer/BioNTech and Moderna vaccines by the European Medicines Agency (EMA) and Food and Drug Administration (FDA) marked a milestone in the fight against the COVID-19 pandemic. The increased public debate about the vaccine development process and vaccine side effects has activated the anti-vaccine community, which has begun to spread conspiracy theories about vaccine safety. OBJECTIVES: Our study is the first to investigate the awareness of Polish patients suffering from various chronic diseases, mainly cancer, about vaccination against SARS-CoV-2. MATERIAL AND METHODS: An anonymous survey was made available from November 2020 to February 2021 to representatives of patient organizations through social media (Facebook) and to patients in the Chemotherapy Department of the Clinical Hospital in Poznań. The survey was completed by 836 patients. The majority of the survey respondents had cancer (77%, n = 644), and almost 1/5 of the respondents indicated hypertension (15.7%, n = 131) as well as depression and/or anxiety disorders (11.1%, n = 93). RESULTS: Less than half of the respondents (43.5%, n = 364) believed that SARS-CoV-2 vaccines were safe (40.4%, n = 260, among cancer patients; 53.9%, n = 104, among patients with other medical conditions). More than half of the respondents (60.5%, n = 506) intended to be vaccinated against SARS-CoV-2 (58.8%, n = 378, among cancer patients; 66.3%, n = 128, among patients with other medical conditions). Fear of vaccine complications and lack of belief in vaccine effectiveness were prevalent among both cancer patients and patients with other medical conditions. CONCLUSIONS: The vast majority of cancer and medical patients wanted to be vaccinated against COVID-19. More than half of the respondents did not believe that the COVID-19 vaccine would be safe for them. Education of cancer and medical patients on the safety and effectiveness of the vaccine, as well as the use of additional protective measures against infection, is an extremely important element of prevention during the COVID-19 pandemic. FAU - Kufel-Grabowska, Joanna AU - Kufel-Grabowska J AD - Department of Electroradiology, Poznan University of Medical Sciences, Poland. AD - Department of Chemotherapy, University Hospital of Lord's Transfiguration, Poznań, Poland. FAU - Bartoszkiewicz, Mikołaj AU - Bartoszkiewicz M AD - Department of Immunobiology, Poznan University of Medical Sciences, Poland. FAU - Ramlau, Rodryg AU - Ramlau R AD - Department and Clinic of Oncology, Poznan University of Medical Sciences, Poland. FAU - Litwiniuk, Maria AU - Litwiniuk M AD - Department of Chemotherapy, The Greater Poland Cancer Center, Poznań, Poland. AD - Department of Cancer Pathology and Prevention, Poznan University of Medical Sciences, Poland. LA - eng PT - Journal Article PL - Poland TA - Adv Clin Exp Med JT - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JID - 101138582 RN - 0 (COVID-19 Vaccines) SB - IM MH - *COVID-19 MH - COVID-19 Vaccines MH - Humans MH - Internal Medicine MH - *Neoplasms MH - Pandemics MH - Poland MH - SARS-CoV-2 MH - Vaccination OTO - NOTNLM OT - COVID-19 OT - cancer patients OT - infection OT - vaccine EDAT- 2021/07/22 06:00 MHDA- 2021/09/01 06:00 CRDT- 2021/07/21 06:47 PHST- 2021/07/22 06:00 [pubmed] PHST- 2021/09/01 06:00 [medline] PHST- 2021/07/21 06:47 [entrez] AID - 10.17219/acem/138962 [doi] PST - ppublish SO - Adv Clin Exp Med. 2021 Aug;30(8):805-811. doi: 10.17219/acem/138962. PMID- 16291011 OWN - NLM STAT- MEDLINE DCOM- 20051215 LR - 20051118 IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 96 IP - 9A DP - 2005 Nov 7 TI - Fixed combination drugs for cardiovascular disease risk reduction: regulatory approach. PG - 28K-33K; discussion 34K-35K AB - The use of combination drug therapy for cardiovascular (CV) disease risk reduction is the established approach to multiple risk factor reduction. The spectrum of rational combination products in CV disease prevention and treatment alone is extremely broad. Development of fixed-dose combination drug products requires information beyond that needed for approval of single active ingredient products. Establishing the rationale and target populations for novel combinations, as well as the contributions of the component drugs to the claimed effects, and characterizing the pharmacokinetics, the pharmacodynamics, and clinical safety and efficacy of the combination are all necessary to support approval. FAU - Orloff, David G AU - Orloff DG AD - US Food and Drug Administration, Rockville, Maryland 20857-0001, USA. orloffd@cder.fda.gov LA - eng PT - Journal Article DEP - 20050919 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Drug Combinations) SB - IM MH - Cardiovascular Diseases/*drug therapy MH - *Drug Combinations MH - Humans MH - Pharmacokinetics MH - Risk Factors MH - United States MH - United States Food and Drug Administration/standards EDAT- 2005/11/18 09:00 MHDA- 2005/12/16 09:00 CRDT- 2005/11/18 09:00 PHST- 2005/11/18 09:00 [pubmed] PHST- 2005/12/16 09:00 [medline] PHST- 2005/11/18 09:00 [entrez] AID - S0002-9149(05)01367-6 [pii] AID - 10.1016/j.amjcard.2005.08.005 [doi] PST - ppublish SO - Am J Cardiol. 2005 Nov 7;96(9A):28K-33K; discussion 34K-35K. doi: 10.1016/j.amjcard.2005.08.005. Epub 2005 Sep 19. PMID- 28407368 OWN - NLM STAT- MEDLINE DCOM- 20180518 LR - 20230829 IS - 1538-7836 (Electronic) IS - 1538-7836 (Linking) VI - 15 IP - 7 DP - 2017 Jul TI - Association of body weight with efficacy and safety outcomes in phase III randomized controlled trials of direct oral anticoagulants: a systematic review and meta-analysis. PG - 1322-1333 LID - 10.1111/jth.13701 [doi] AB - Essentials The association of body weight and patient-important outcomes remains unknown. Phase III randomized controlled trials of direct oral anticoagulants (DOACs) were searched. Risk of outcomes varying among body weight subgroups is not attributable to anticoagulant type. Dose adjustment of DOACs, outside that recommended, is unlikely to improve the outcomes. Click to hear Dr Braunwald's perspective on antithrombotic therapy in cardiovascular disease SUMMARY: Background Concerns have arisen in direct oral anticoagulant (DOAC)-treated patients about safety and efficacy in extremes of body weight. The aims of this systematic review were to investigate the association of body weight and patient-important outcomes in patients treated with DOACs or warfarin, and to demonstrate the fixed-dose effect of DOACs. Methods MEDLINE and EMBASE were searched until November 2016. Phase III randomized controlled trials (RCTs) using DOACs in atrial fibrillation (AF) and acute venous thromboembolism (VTE) were included. Relative risk and 95% confidence interval were calculated. The pooled estimates were performed using a Mantel-Haenszel random effects model. Results A total of 11 phase III RCTs were included. Low body weight was associated with increased risk of thromboembolism compared with non-low body weight (relative risk [RR], 1.57; 95% confidence interval [CI], 1.34-1.85). High body weight was not associated with risk of thromboembolism compared with non-high body weight (RR, 0.88; 95% CI, 0.63-1.23). The subgroup of AF patients with high body weight had a lower risk of thromboembolism compared with non-high body weight (RR, 0.43; 95% CI, 0.28-0.67). Bleeding outcomes were comparable for all body weight comparisons. There were no clear interactions between types of anticoagulant in all outcomes. Conclusion The pooled effect of both the DOAC and comparison arms was likely to be attributable to differences in baseline thrombotic risk in each body weight category, rather than an effect of the type or dose of DOAC used for each indication. Dose adjustment of DOACs, outside that recommended in the package insert, is unlikely to improve safety or efficacy. CI - © 2017 International Society on Thrombosis and Haemostasis. FAU - Boonyawat, K AU - Boonyawat K AD - Department of Medicine, McMaster University, Hamilton, ON, Canada. AD - Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Caron, F AU - Caron F AD - Population Health Research Institute, Hamilton, ON, Canada. FAU - Li, A AU - Li A AD - Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA. FAU - Chai-Adisaksopha, C AU - Chai-Adisaksopha C AUID- ORCID: 0000-0001-7209-9722 AD - Department of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Lim, W AU - Lim W AD - Department of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Iorio, A AU - Iorio A AUID- ORCID: 0000-0002-3331-8766 AD - Department of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Lopes, R D AU - Lopes RD AD - Duke Clinical Research Institute, Duke Medicine, Durham, NC, USA. FAU - Garcia, D AU - Garcia D AD - Department of Medicine, University of Washington, Seattle, WA, USA. FAU - Crowther, M A AU - Crowther MA AD - Department of Medicine, McMaster University, Hamilton, ON, Canada. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20170509 PL - England TA - J Thromb Haemost JT - Journal of thrombosis and haemostasis : JTH JID - 101170508 RN - 0 (Anticoagulants) RN - 5Q7ZVV76EI (Warfarin) SB - IM MH - Acute Disease MH - Anticoagulants/*adverse effects/therapeutic use MH - Atrial Fibrillation/*drug therapy MH - *Body Weight MH - Clinical Trials, Phase III as Topic MH - Hemorrhage MH - Humans MH - Randomized Controlled Trials as Topic MH - Risk MH - Sensitivity and Specificity MH - Thromboembolism/drug therapy MH - Treatment Outcome MH - Venous Thromboembolism/*drug therapy MH - Warfarin/*adverse effects/therapeutic use OTO - NOTNLM OT - anticoagulants OT - body weight OT - hemorrhage OT - meta-analysis OT - thromboembolism EDAT- 2017/04/14 06:00 MHDA- 2018/05/19 06:00 CRDT- 2017/04/14 06:00 PHST- 2017/01/05 00:00 [received] PHST- 2017/04/14 06:00 [pubmed] PHST- 2018/05/19 06:00 [medline] PHST- 2017/04/14 06:00 [entrez] AID - S1538-7836(22)04293-3 [pii] AID - 10.1111/jth.13701 [doi] PST - ppublish SO - J Thromb Haemost. 2017 Jul;15(7):1322-1333. doi: 10.1111/jth.13701. Epub 2017 May 9. PMID- 24969078 OWN - NLM STAT- MEDLINE DCOM- 20150511 LR - 20140830 IS - 1423-002X (Electronic) IS - 0378-7346 (Linking) VI - 78 IP - 2 DP - 2014 TI - Laparoendoscopic single-site surgery for extremely large ovarian cysts: a feasibility, safety, and patient satisfaction study. PG - 81-7 LID - 10.1159/000363237 [doi] AB - BACKGROUND/AIMS: To assess the feasibility, safety and patient satisfaction of laparoendoscopic single-site (LESS) surgery for extremely large ovarian cysts. METHODS: We conducted a prospective study of LESS surgery among women with ovarian cysts with a minimum diameter ≥15 cm and with radiological and laboratory features suggestive of benign disease. The primary outcomes were perioperative complication rate, conversion rate and patient satisfaction. RESULTS: A total of 21 consecutive patients underwent the following LESS surgery over a period of 17 months: ovarian cystectomy (76%), adnexectomy (10%) and staging procedure (14%). Histological findings included benign (85%), borderline (10%) and malignant tumors (5%). Spillage occurred for 2 patients (10%). LESS surgery was successful without conversion in 20 patients (95%). There was 1 perioperative complication with subcutaneous hematoma (5%). The median operative time and estimated blood loss were 79.8 min (39-155) and 60 ml (10-180), respectively. Patients were highly satisfied with the results of LESS surgery, with a mean surgery satisfaction score of 9.4 ± 0.8 on a scale of 1-10. More than 71% of patients reported that the scar was invisible, and 95% said that they would recommend LESS surgery to others. CONCLUSION: Based on our results, with proper patient selection, the size of an ovarian cyst does not necessarily constitute a contraindication for LESS surgery. CI - © 2014 S. Karger AG, Basel. FAU - Song, Taejong AU - Song T AD - Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. FAU - Kim, Mi Kyoung AU - Kim MK FAU - Kim, Mi-La AU - Kim ML FAU - Yoon, Bo Sung AU - Yoon BS FAU - Seong, Seok Ju AU - Seong SJ LA - eng PT - Journal Article DEP - 20140620 PL - Switzerland TA - Gynecol Obstet Invest JT - Gynecologic and obstetric investigation JID - 7900587 SB - IM MH - Adult MH - Blood Loss, Surgical MH - Feasibility Studies MH - Female MH - Humans MH - Laparoscopy/adverse effects/*methods MH - Middle Aged MH - Operative Time MH - Ovarian Cysts/diagnosis/*pathology/*surgery MH - Patient Satisfaction MH - Prospective Studies MH - Treatment Outcome EDAT- 2014/06/28 06:00 MHDA- 2015/05/12 06:00 CRDT- 2014/06/28 06:00 PHST- 2013/09/24 00:00 [received] PHST- 2014/04/24 00:00 [accepted] PHST- 2014/06/28 06:00 [entrez] PHST- 2014/06/28 06:00 [pubmed] PHST- 2015/05/12 06:00 [medline] AID - 000363237 [pii] AID - 10.1159/000363237 [doi] PST - ppublish SO - Gynecol Obstet Invest. 2014;78(2):81-7. doi: 10.1159/000363237. Epub 2014 Jun 20. PMID- 34695925 OWN - NLM STAT- MEDLINE DCOM- 20211027 LR - 20211029 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 21 IP - 20 DP - 2021 Oct 9 TI - 3D Object Detection with SLS-Fusion Network in Foggy Weather Conditions. LID - 10.3390/s21206711 [doi] LID - 6711 AB - The role of sensors such as cameras or LiDAR (Light Detection and Ranging) is crucial for the environmental awareness of self-driving cars. However, the data collected from these sensors are subject to distortions in extreme weather conditions such as fog, rain, and snow. This issue could lead to many safety problems while operating a self-driving vehicle. The purpose of this study is to analyze the effects of fog on the detection of objects in driving scenes and then to propose methods for improvement. Collecting and processing data in adverse weather conditions is often more difficult than data in good weather conditions. Hence, a synthetic dataset that can simulate bad weather conditions is a good choice to validate a method, as it is simpler and more economical, before working with a real dataset. In this paper, we apply fog synthesis on the public KITTI dataset to generate the Multifog KITTI dataset for both images and point clouds. In terms of processing tasks, we test our previous 3D object detector based on LiDAR and camera, named the Spare LiDAR Stereo Fusion Network (SLS-Fusion), to see how it is affected by foggy weather conditions. We propose to train using both the original dataset and the augmented dataset to improve performance in foggy weather conditions while keeping good performance under normal conditions. We conducted experiments on the KITTI and the proposed Multifog KITTI datasets which show that, before any improvement, performance is reduced by 42.67% in 3D object detection for Moderate objects in foggy weather conditions. By using a specific strategy of training, the results significantly improved by 26.72% and keep performing quite well on the original dataset with a drop only of 8.23%. In summary, fog often causes the failure of 3D detection on driving scenes. By additional training with the augmented dataset, we significantly improve the performance of the proposed 3D object detection algorithm for self-driving cars in foggy weather conditions. FAU - Mai, Nguyen Anh Minh AU - Mai NAM AUID- ORCID: 0000-0001-9672-8909 AD - Cerema, Equipe-Projet STI, 1 Avenue du Colonel Roche, 31400 Toulouse, France. AD - Institut de Recherche en Informatique de Toulouse, Université de Toulouse, UPS, 31062 Toulouse, France. FAU - Duthon, Pierre AU - Duthon P AUID- ORCID: 0000-0002-6705-1131 AD - Cerema, Equipe-Projet STI, 8-10, Rue Bernard Palissy, 63017 Clermont-Ferrand, France. FAU - Khoudour, Louahdi AU - Khoudour L AUID- ORCID: 0000-0002-5947-4302 AD - Cerema, Equipe-Projet STI, 1 Avenue du Colonel Roche, 31400 Toulouse, France. FAU - Crouzil, Alain AU - Crouzil A AUID- ORCID: 0000-0001-7040-2978 AD - Institut de Recherche en Informatique de Toulouse, Université de Toulouse, UPS, 31062 Toulouse, France. FAU - Velastin, Sergio A AU - Velastin SA AUID- ORCID: 0000-0001-6775-7137 AD - Department of Computer Science and Engineering, Universidad Carlos III de Madrid, Leganés, 28911 Madrid, Spain. AD - School of Electronic Engineering and Computer Science, Queen Mary University of London, London E1 4NS, UK. LA - eng PT - Journal Article DEP - 20211009 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Algorithms MH - *Automobile Driving MH - Rain MH - Research Design MH - Weather PMC - PMC8540926 OTO - NOTNLM OT - 3D object detection OT - adverse weather conditions OT - autonomous vehicles OT - foggy perception OT - synthetic datasets COIS- The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript nor in the decision to publish the results. EDAT- 2021/10/27 06:00 MHDA- 2021/10/28 06:00 PMCR- 2021/10/09 CRDT- 2021/10/26 01:01 PHST- 2021/08/29 00:00 [received] PHST- 2021/09/29 00:00 [revised] PHST- 2021/09/30 00:00 [accepted] PHST- 2021/10/26 01:01 [entrez] PHST- 2021/10/27 06:00 [pubmed] PHST- 2021/10/28 06:00 [medline] PHST- 2021/10/09 00:00 [pmc-release] AID - s21206711 [pii] AID - sensors-21-06711 [pii] AID - 10.3390/s21206711 [doi] PST - epublish SO - Sensors (Basel). 2021 Oct 9;21(20):6711. doi: 10.3390/s21206711. PMID- 34884349 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211214 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 10 IP - 23 DP - 2021 Nov 30 TI - Restoration of Fertility in Patients with Spontaneous Premature Ovarian Insufficiency: New Techniques under the Microscope. LID - 10.3390/jcm10235647 [doi] LID - 5647 AB - Premature ovarian insufficiency (POI), a condition affecting up to 1% of women by the age of 40 years, is characterized by an extremely low chance of spontaneous pregnancy. Currently, fertility restoration options are virtually nonexistent for this population. To become pregnant, the only solution is egg donation. Interestingly, animal studies have provided encouraging results in terms of fertility restoration, and consequently, research has begun into the most promising approaches for women suffering from POI. The PubMed database was searched for studies in which techniques aiming at restoring fertility in women with spontaneous POI were tested. Although robust studies are lacking, the literature suggests a positive effect of certain techniques on fertility restoration in women with POI. The most promising approaches seem to be intraovarian injection of autologous platelet-rich plasma or of mesenchymal stem cells. In addition to these, in vitro and mechanical activation of dormant follicles and etiology-driven therapies have also been studied with mixed results. No safety concerns were raised in these studies. The absence of robust studies does not allow us to draw meaningful conclusions on the efficacy or superiority of any single technique at this stage, and so research in this area should continue using robust study designs, i.e., multicenter randomized controlled trials including sufficient subjects to achieve statistical power. FAU - Mawet, Marie AU - Mawet M AUID- ORCID: 0000-0003-2276-7758 AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHU, Avenue de l'Hopital 1, 4000 Liège, Belgium. FAU - Perrier d'Hauterive, Sophie AU - Perrier d'Hauterive S AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHR, Boulevard du 12ème de Ligne, 4000 Liège, Belgium. AD - GIGA-Stem Cells, Uliège, Site du CHU, Avenue de l'Hopital 1, 4000 Liège, Belgium. FAU - Henry, Laurie AU - Henry L AUID- ORCID: 0000-0002-6162-1551 AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHR, Boulevard du 12ème de Ligne, 4000 Liège, Belgium. FAU - Potorac, Iulia AU - Potorac I AD - Service d'Endocrinologie, Uliège, Site du CHU, Avenue de l'Hopital 1, 4000 Liège, Belgium. FAU - Kridelka, Frédéric AU - Kridelka F AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHU, Avenue de l'Hopital 1, 4000 Liège, Belgium. FAU - Nisolle, Michelle AU - Nisolle M AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHR, Boulevard du 12ème de Ligne, 4000 Liège, Belgium. FAU - Pintiaux, Axelle AU - Pintiaux A AD - Service de Gynécologie-Obstétrique, Uliège, Site du CHU, Avenue de l'Hopital 1, 4000 Liège, Belgium. LA - eng PT - Journal Article PT - Review DEP - 20211130 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC8658421 OTO - NOTNLM OT - fertility restoration OT - mesenchymal stem cells OT - platelet-rich plasma OT - premature ovarian insufficiency OT - primary ovarian insufficiency COIS- The authors declare no conflict of interest. EDAT- 2021/12/11 06:00 MHDA- 2021/12/11 06:01 PMCR- 2021/11/30 CRDT- 2021/12/10 01:03 PHST- 2021/10/10 00:00 [received] PHST- 2021/11/24 00:00 [revised] PHST- 2021/11/27 00:00 [accepted] PHST- 2021/12/10 01:03 [entrez] PHST- 2021/12/11 06:00 [pubmed] PHST- 2021/12/11 06:01 [medline] PHST- 2021/11/30 00:00 [pmc-release] AID - jcm10235647 [pii] AID - jcm-10-05647 [pii] AID - 10.3390/jcm10235647 [doi] PST - epublish SO - J Clin Med. 2021 Nov 30;10(23):5647. doi: 10.3390/jcm10235647. PMID- 18807485 OWN - NLM STAT- MEDLINE DCOM- 20081125 LR - 20131121 IS - 0033-2100 (Print) IS - 0033-2100 (Linking) VI - 62 IP - 2 DP - 2008 TI - [Current opportunities for treatment of chronic hepatitis C in patients with HIV co-infection]. PG - 383-91 AB - Liver diseases, mainly chronic viral hepatitis, recently have become the main cause of hospitalization and death in individuals with HIV infection. As HCV infection is predominant condition in this group of patients, treatment of hepatitis C is extremely important in halting hepatic injury. Large clinical trials (APRICOT, RIBAVIC, ACTG 5071) showed satisfactory efficacy and safety of therapy with pegylated interferon alpha and ribavirin. Other trials, searching ways to improve efficacy of chronic hepatitis C treatment in HIV co-infected individuals, are still running. Management possibilities include higher doses of ribavirin and, prolonged course of treatment. The article summarizes current state of knowledge in the field of chronic hepatitis C treatment in HIV/HCV-coinfected individuals. FAU - Inglot, Małgorzata AU - Inglot M AD - Katedra i Klinika Chorób Zakaźnych, Chorób Watroby i Nabytych Niedoborów, Odpornościowych Akademii Medycznej we Wrocławiu. minglot@k.pl FAU - Szymczak, Aleksandra AU - Szymczak A FAU - Gasiorowski, Jacek AU - Gasiorowski J LA - pol PT - English Abstract PT - Journal Article PT - Review TT - Aktualne mozliwości leczenia przewlekłego wzw typu C u chorych zakazonych HIV. PL - Poland TA - Przegl Epidemiol JT - Przeglad epidemiologiczny JID - 0413725 RN - 0 (Anti-HIV Agents) RN - 49717AWG6K (Ribavirin) RN - 9008-11-1 (Interferons) SB - IM MH - AIDS-Related Opportunistic Infections/*drug therapy/epidemiology MH - Anti-HIV Agents/therapeutic use MH - Comorbidity MH - Evidence-Based Medicine MH - Hepatitis C, Chronic/*drug therapy/epidemiology MH - Humans MH - Interferons/*therapeutic use MH - Poland/epidemiology MH - Primary Health Care/*organization & administration MH - Randomized Controlled Trials as Topic MH - Ribavirin/*therapeutic use MH - Risk Assessment RF - 27 EDAT- 2008/09/24 09:00 MHDA- 2008/12/17 09:00 CRDT- 2008/09/24 09:00 PHST- 2008/09/24 09:00 [pubmed] PHST- 2008/12/17 09:00 [medline] PHST- 2008/09/24 09:00 [entrez] PST - ppublish SO - Przegl Epidemiol. 2008;62(2):383-91. PMID- 34758685 OWN - NLM STAT- MEDLINE DCOM- 20220225 LR - 20220501 IS - 1744-7666 (Electronic) IS - 1465-6566 (Linking) VI - 23 IP - 4 DP - 2022 Mar TI - The evolving atopic dermatitis management landscape. PG - 517-526 LID - 10.1080/14656566.2021.1999412 [doi] AB - INTRODUCTION: Atopic dermatitis is a common dermatologic condition that affects millions of people worldwide, and a standardized approach to treatment was published by the American Academy of Dermatology (AAD) in 2013-14. Since 2014, new FDA-approved treatment options such as dupilumab and crisaborole have changed the landscape of AD management, and future therapies such as JAK inhibitors and anti-interleukin 13 and 31 antibodies appear effective, emphasizing the need for a comprehensive review to give clinicians an updated toolbox to aid in pharmacologic management. AREAS COVERED: In this review, the authors explore the updated efficacy and safety data on established therapeutic options for AD including topical corticosteroids, topical calcineurin inhibitors, cyclosporine, azathioprine, methotrexate, and mycophenolate mofetil. In addition, the authors also explore trial data and studies on dupilumab, crisaborole, omalizumab, tofacitinib, ruxolinitib, abrocitinib, baricitinib, upadacitinib, delgocitinib, nemoliuzumab, and tralokinumab. EXPERT OPINION: The AAD guidelines must be updated in the future to include several new treatment modalities that have revolutionized the pharmacologic management of patients with AD, including dupilumab and crisaborole. The future of AD treatment is also extremely bright, as JAK inhibitors and Il-13/31 antibodies have shown convincing results in the improvement of AD patients' lives in various trials and studies that have been examined in this paper. FAU - Sahni, Vikram N AU - Sahni VN AD - Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. FAU - Balogh, Esther A AU - Balogh EA AD - Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. FAU - Strowd, Lindsay C AU - Strowd LC AD - Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. FAU - Feldman, Steven R AU - Feldman SR AD - Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. AD - Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. AD - Department of Pathology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. AD - Department of Social Sciences & Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA. AD - Department of Dermatology, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article PT - Review DEP - 20211110 PL - England TA - Expert Opin Pharmacother JT - Expert opinion on pharmacotherapy JID - 100897346 RN - 0 (Dermatologic Agents) RN - 0 (Janus Kinase Inhibitors) RN - 83HN0GTJ6D (Cyclosporine) SB - IM EIN - Expert Opin Pharmacother. 2022 Mar;23(4):i. doi: 10.1080/14656566.2021.2016333. PMID: 34986719 MH - Cyclosporine/therapeutic use MH - *Dermatitis, Atopic/drug therapy MH - *Dermatologic Agents/therapeutic use MH - *Eczema/drug therapy MH - Humans MH - *Janus Kinase Inhibitors/therapeutic use OTO - NOTNLM OT - AAD guidelines OT - Atopic dermatitis OT - JAK inhibitor OT - crisaborole OT - dupilumab OT - eczema OT - omalizumab OT - pharmacotherapy OT - treatment OT - update EDAT- 2021/11/12 06:00 MHDA- 2022/02/26 06:00 CRDT- 2021/11/11 05:35 PHST- 2021/11/12 06:00 [pubmed] PHST- 2022/02/26 06:00 [medline] PHST- 2021/11/11 05:35 [entrez] AID - 10.1080/14656566.2021.1999412 [doi] PST - ppublish SO - Expert Opin Pharmacother. 2022 Mar;23(4):517-526. doi: 10.1080/14656566.2021.1999412. Epub 2021 Nov 10. PMID- 24387673 OWN - NLM STAT- MEDLINE DCOM- 20140925 LR - 20220311 IS - 1749-8090 (Electronic) IS - 1749-8090 (Linking) VI - 9 DP - 2014 Jan 3 TI - Hybrid procedure to treat aortic arch aneurysm combined with aortic arch coarctation and left internal carotid artery aneurysm (Case Report). PG - 3 LID - 10.1186/1749-8090-9-3 [doi] AB - Aortic arch aneurysm is a rare condition but carries a high risk of rupture. We report one case of aortic arch aneurysm combined with aortic arch coarctation and left internal carotid artery aneurysm, which is extremely rare. Left internal carotid artery aneurysm resection and revascularization, carotid and carotid graft bypass combined with endovascular stent graft and embolization with coils were successfully performed. There were no any complaints and complications at 8 months follow-up. The follow-up CTA demonstrated thrombus formation in the aneurysm lumen, no endoleak and the aortic arch and bypass graft were all patent. We feel that hybrid procedure may be a valuable therapeutic alternative when treating this type of lesion. However, long-term clinical efficacy and safety have yet to be confirmed. FAU - Zhou, Weimin AU - Zhou W AD - Department of Vascular Surgery, the second affiliated hospital of Nanchang University, No 1#, Minde Road, Nanchang, China. drzwm@sina.com. FAU - Zhou, Wei AU - Zhou W FAU - Qiu, Jiehua AU - Qiu J FAU - Zeng, Qingzhong AU - Zeng Q LA - eng PT - Case Reports PT - Journal Article DEP - 20140103 PL - England TA - J Cardiothorac Surg JT - Journal of cardiothoracic surgery JID - 101265113 SB - IM MH - Aneurysm/complications/diagnostic imaging/*therapy MH - Angiography, Digital Subtraction MH - Aortic Aneurysm, Thoracic/complications/diagnostic imaging/therapy MH - Aortic Coarctation/complications/diagnostic imaging/*therapy MH - Blood Vessel Prosthesis Implantation/*methods MH - *Carotid Artery, Internal MH - Embolization, Therapeutic/*methods MH - Endovascular Procedures/*methods MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - *Stents MH - Time Factors MH - Tomography, X-Ray Computed PMC - PMC3898389 EDAT- 2014/01/07 06:00 MHDA- 2014/09/26 06:00 PMCR- 2014/01/03 CRDT- 2014/01/07 06:00 PHST- 2013/08/12 00:00 [received] PHST- 2013/12/30 00:00 [accepted] PHST- 2014/01/07 06:00 [entrez] PHST- 2014/01/07 06:00 [pubmed] PHST- 2014/09/26 06:00 [medline] PHST- 2014/01/03 00:00 [pmc-release] AID - 1749-8090-9-3 [pii] AID - 10.1186/1749-8090-9-3 [doi] PST - epublish SO - J Cardiothorac Surg. 2014 Jan 3;9:3. doi: 10.1186/1749-8090-9-3. PMID- 16797675 OWN - NLM STAT- MEDLINE DCOM- 20060929 LR - 20240109 IS - 0048-9697 (Print) IS - 0048-9697 (Linking) VI - 366 IP - 2-3 DP - 2006 Aug 1 TI - Radiological consequences of the extreme flooding on the lower course of the Rhone valley (December 2003, south east France). PG - 427-38 AB - In early December 2003 unusual weather conditions led to major flooding of the lower Rhone valley. When it floods, the Rhone carries large masses of solid matter in suspension, which potentially includes associated artificial (anthropogenic) radioactive contaminants from soil drainage in the catchment area and from re-uptake of sedimentary matter that has been contaminated with low-level radioactive liquid effluents from almost twenty nuclear facilities situated along the Rhone valley. A sampling campaign was carried out to investigate the level and spread of both sediment mass and associated radioactive contamination across the flooded areas. An attempt was made to assess the radiological consequences of such an extreme event on contamination of the food chain. Our results show that almost 700,000 tons of sediment was transported onto the floodplain, of which 80% were coarse and fine sands. These materials transferred 6660 MBq of 137Cs, 93 MBq of (239+240)Pu, 13 MBq of 238Pu and 204 MBq of 60Co over a surface area of 60 km2. More than 90% of deposited sediments are concentrated in a 10 km2 area of agricultural soils, and we estimated that 18% were plowed into the soil. Nevertheless, the level of activity measured in the vegetable crops and milk was not significantly different from the level measured in similar samples from regions that were not affected by the December 2003 floods. FAU - Eyrolle, F AU - Eyrolle F AD - Institute for Radioprotection and Nuclear Safety, Division for Environment and Intervention, Continental and Marine Radiological Research Laboratory, BP3, 13115 St Paul Lez Durance cedex, France. frederique.eyrolle@irsn.fr FAU - Duffa, C AU - Duffa C FAU - Antonelli, C AU - Antonelli C FAU - Rolland, B AU - Rolland B FAU - Leprieur, F AU - Leprieur F LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060622 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Cesium Radioisotopes) RN - 0 (Cobalt Radioisotopes) RN - 0 (Radioactive Fallout) RN - 0 (Water Pollutants, Radioactive) RN - 53023GN24M (Plutonium) SB - IM MH - Animals MH - Beta vulgaris/chemistry MH - Cesium Radioisotopes/*analysis MH - Cobalt Radioisotopes/*analysis MH - Disasters MH - Food Contamination, Radioactive MH - France MH - Geologic Sediments MH - Lactuca/chemistry MH - Milk/chemistry MH - Plutonium/*analysis MH - Poaceae/chemistry MH - Power Plants MH - Radiation Monitoring MH - Radioactive Fallout MH - Rivers MH - Spinacia oleracea/chemistry MH - Water Pollutants, Radioactive/*analysis EDAT- 2006/06/27 09:00 MHDA- 2006/09/30 09:00 CRDT- 2006/06/27 09:00 PHST- 2005/07/18 00:00 [received] PHST- 2005/12/08 00:00 [revised] PHST- 2005/12/09 00:00 [accepted] PHST- 2006/06/27 09:00 [pubmed] PHST- 2006/09/30 09:00 [medline] PHST- 2006/06/27 09:00 [entrez] AID - S0048-9697(05)00888-0 [pii] AID - 10.1016/j.scitotenv.2005.12.010 [doi] PST - ppublish SO - Sci Total Environ. 2006 Aug 1;366(2-3):427-38. doi: 10.1016/j.scitotenv.2005.12.010. Epub 2006 Jun 22. PMID- 37003147 OWN - NLM STAT- MEDLINE DCOM- 20230501 LR - 20230501 IS - 1873-3557 (Electronic) IS - 1386-1425 (Linking) VI - 296 DP - 2023 Aug 5 TI - A novel AIE fluorescence probe featuring with high quantum yield for high-fidelity lysosomal targeting and tracking. PG - 122657 LID - S1386-1425(23)00342-6 [pii] LID - 10.1016/j.saa.2023.122657 [doi] AB - High-fidelity imaging and long-term visualization of lysosomes are pivotal factors in the functional assessment of lysosomes, which perform an instrumental role in the physiological activity of cells. However, commercial probes have great limitations in lysosome exploration resulting from the aggregation-caused quenching effect as well as photobleaching instability and small Stokes shift. Therefore, we constructed a novel probe named TTAM with triphenylamine as the matrix and morpholine ring as the targeting group. In contrast with commonly accessible Lyso-tracker Red, TTAM has the merits of aggregation-induced emission effect, extremely high quantum yields (51.57 % solid-state) as well as fluorescence intensity, significant photostability, and high resolution. These properties make it ideal for imaging and activity monitoring lysosomes, which provides a powerful condition for bio-imaging. CI - Copyright © 2023 Elsevier B.V. All rights reserved. FAU - Zhang, Pan AU - Zhang P AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. FAU - Xue, Ke AU - Xue K AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. FAU - Dai, Yanpeng AU - Dai Y AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. FAU - Zhao, Xinxin AU - Zhao X AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. FAU - Zhang, Dongdong AU - Zhang D AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. FAU - Wei, Pengfei AU - Wei P AD - Special Equipment Safety Supervision Inspection Institue of Jiangsu Province, Nanjing, Jiangsu 210003, PR China. FAU - Qi, Zhengjian AU - Qi Z AD - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, PR China. Electronic address: qizhengjian@seu.edu.cn. LA - eng PT - Journal Article DEP - 20230321 PL - England TA - Spectrochim Acta A Mol Biomol Spectrosc JT - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JID - 9602533 RN - 0 (Fluorescent Dyes) SB - IM MH - *Fluorescent Dyes/pharmacology MH - Fluorescence MH - *Lysosomes MH - Diagnostic Imaging OTO - NOTNLM OT - Bio-imaging OT - High quantum yield OT - Lysosome-targeting aggregation-induced emission COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/04/02 06:00 MHDA- 2023/05/01 06:42 CRDT- 2023/04/01 18:08 PHST- 2023/02/25 00:00 [received] PHST- 2023/03/16 00:00 [revised] PHST- 2023/03/18 00:00 [accepted] PHST- 2023/05/01 06:42 [medline] PHST- 2023/04/02 06:00 [pubmed] PHST- 2023/04/01 18:08 [entrez] AID - S1386-1425(23)00342-6 [pii] AID - 10.1016/j.saa.2023.122657 [doi] PST - ppublish SO - Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5;296:122657. doi: 10.1016/j.saa.2023.122657. Epub 2023 Mar 21. PMID- 39597514 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20241130 IS - 2076-2607 (Print) IS - 2076-2607 (Electronic) IS - 2076-2607 (Linking) VI - 12 IP - 11 DP - 2024 Oct 23 TI - Investigating the Potential of L(+)-Lactic Acid as a Green Inhibitor and Eradicator of a Dual-Species Campylobacter spp. Biofilm Formed on Food Processing Model Surfaces. LID - 10.3390/microorganisms12112124 [doi] LID - 2124 AB - Campylobacter spp. are prevalent foodborne bacterial enteric pathogens. Their inclusion in biofilms on abiotic surfaces is considered a strategy that facilitates their extraintestinal survival. Organic acid (OA) treatments could be used in a green approach to decontaminate various surfaces. This work aimed to evaluate the inhibitory and eradicative effects of L(+)-lactic acid (LA), a naturally occurring OA, on a dual-species biofilm formed on two food processing model surfaces (polystyrene and stainless steel) by three selected foodborne Campylobacter spp. isolates (two C. jejuni and one C. coli). The influence of aerobiosis conditions (microaerophilic, aerobic and CO(2) enriched) on the resistance of the established biofilms to the acid was also tested. In parallel, the predominant metabolites contained in the planktonic media of biofilm monocultures and mixed-culture biofilm were comparatively analyzed by an untargeted metabolomics approach. Results revealed that LA inhibited mixed-culture biofilm formation by more than 2 logs (>99%) on both surfaces when this was applied at its highest tested concentration (4096 μg/mL; 0.34% v/v). However, all the preformed mixed-culture biofilms (ca. 10(6-7) CFU/cm(2)) could not be eradicated even when the acid was used at concentrations exceeding 5% v/v, denoting their extremely high recalcitrance which was still influenced by the abiotic substratum, and the biofilm-forming aerobiosis conditions. The metabolic analysis revealed a strain-specific metabolite production which might also be related to the strain-specific biofilm-forming and resistance behaviors and resulted in the distinct clustering of the different samples. Overall, the current findings provide important information on the effectiveness of LA against biofilm campylobacteria and may assist in mitigating their risk in the food chain. FAU - Kostoglou, Dimitra AU - Kostoglou D AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. FAU - Apostolopoulou, Martha AU - Apostolopoulou M AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. FAU - Lagou, Athina AU - Lagou A AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. FAU - Didos, Spyros AU - Didos S AUID- ORCID: 0009-0000-6566-7277 AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. FAU - Argiriou, Anagnostis AU - Argiriou A AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. FAU - Giaouris, Efstathios AU - Giaouris E AUID- ORCID: 0000-0002-6019-5204 AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Myrina, Lemnos, Greece. LA - eng GR - 5046750/EPAnEk-NRSF 2014-2020/ PT - Journal Article DEP - 20241023 PL - Switzerland TA - Microorganisms JT - Microorganisms JID - 101625893 PMC - PMC11596057 OTO - NOTNLM OT - Campylobacter OT - aerobiosis conditions OT - disinfection OT - food safety OT - mixed-culture biofilms OT - natural antimicrobials OT - polystyrene OT - public health OT - stainless steel OT - untargeted metabolomics COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2024/11/27 06:19 MHDA- 2024/11/27 06:20 PMCR- 2024/10/23 CRDT- 2024/11/27 01:30 PHST- 2024/09/13 00:00 [received] PHST- 2024/10/18 00:00 [revised] PHST- 2024/10/22 00:00 [accepted] PHST- 2024/11/27 06:20 [medline] PHST- 2024/11/27 06:19 [pubmed] PHST- 2024/11/27 01:30 [entrez] PHST- 2024/10/23 00:00 [pmc-release] AID - microorganisms12112124 [pii] AID - microorganisms-12-02124 [pii] AID - 10.3390/microorganisms12112124 [doi] PST - epublish SO - Microorganisms. 2024 Oct 23;12(11):2124. doi: 10.3390/microorganisms12112124. PMID- 34168458 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220424 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 14 DP - 2021 TI - Google Glass-Supported Cooperative Training for Health Professionals: A Case Study Based on Using Remote Desktop Virtual Support. PG - 1451-1462 LID - 10.2147/JMDH.S311766 [doi] AB - PURPOSE: Observation of medical trainees' care performance by experts can be extremely helpful for ensuring safety and providing quality care. The advanced technology of smart glasses enables health professionals to video stream their operations to remote supporters for collaboration and cooperation. This study monitored the clinical situation by using smart glasses for remote cooperative training via video streaming and clinical decision-making through simulation based on a scenario of emergency nursing care for patients with arrhythmia. PARTICIPANTS AND METHODS: The clinical operations of bedside trainees, who is Google Glass Enterprise Edition 2(Glass EE2) wearers, were live streamed via their Google Glasses, which were viewed at a remote site by remote supporters via a desktop computer. Data were obtained from 31 nursing students using eight essay questions regarding their experience as desktop-side remote supporters. RESULTS: Most of the participants reported feeling uneasy about identifying clinical situations (84%), patients' condition (72%), and trainees' performance (69%). The current system demonstrated sufficient performance with a satisfactory level of image quality and auditory communication, while network and connectivity are areas that require further improvement. The reported barriers to identifying situations on the remote desktop were predominantly a narrow field of view and motion blur in videos captured by Glass EE2s, and using the customized mirror mode. CONCLUSION: The current commercial Glass EE2 can facilitate enriched communication between remotely located supporters and trainees by sharing live videos and audio during clinical operations. Further improvement of hardware and software user interfaces will ensure better applicability of smart glasses and video streaming functions to clinical practice settings. CI - © 2021 Yoon et al. FAU - Yoon, Hyoseok AU - Yoon H AUID- ORCID: 0000-0002-9907-0775 AD - Division of Computer Engineering, Hanshin University, Osan, Korea. FAU - Kim, Sun Kyung AU - Kim SK AUID- ORCID: 0000-0001-8839-5577 AD - Department of Nursing, and Department of Biomedicine, Health & Life Convergence Sciences, BK21 Four, Biomedical and Healthcare Research Institute, Mokpo National University, Jeonnam, Korea. FAU - Lee, Youngho AU - Lee Y AD - Department of Computer Engineering, Mokpo National University, Jeonnam, Korea. FAU - Choi, Jongmyung AU - Choi J AD - Department of Computer Engineering, Mokpo National University, Jeonnam, Korea. LA - eng PT - Journal Article DEP - 20210617 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC8216757 OTO - NOTNLM OT - cooperation OT - google glass engerprise edition 2 OT - health professional OT - interaction OT - remote support OT - smart glass COIS- The authors report no conflicts of interest in this work. EDAT- 2021/06/26 06:00 MHDA- 2021/06/26 06:01 PMCR- 2021/06/17 CRDT- 2021/06/25 06:48 PHST- 2021/03/22 00:00 [received] PHST- 2021/05/31 00:00 [accepted] PHST- 2021/06/25 06:48 [entrez] PHST- 2021/06/26 06:00 [pubmed] PHST- 2021/06/26 06:01 [medline] PHST- 2021/06/17 00:00 [pmc-release] AID - 311766 [pii] AID - 10.2147/JMDH.S311766 [doi] PST - epublish SO - J Multidiscip Healthc. 2021 Jun 17;14:1451-1462. doi: 10.2147/JMDH.S311766. eCollection 2021. PMID- 33029792 OWN - NLM STAT- MEDLINE DCOM- 20210504 LR - 20210504 IS - 1879-3479 (Electronic) IS - 0020-7292 (Linking) VI - 153 IP - 1 DP - 2021 Apr TI - Stillbirths and neonatal deaths among 18 942 women with postpartum hemorrhage: Analysis of perinatal outcomes in the WOMAN trial. PG - 146-153 LID - 10.1002/ijgo.13413 [doi] AB - OBJECTIVE: To describe the rates and risk factors for stillbirth and pre-discharge neonatal mortality (PDNM), and impact on quality of life (QoL) among women with postpartum hemorrhage (PPH). METHODS: A secondary analysis was conducted of the WOMAN trial, which evaluated the use of tranexamic acid for PPH and collected infant outcome data to assess drug safety. The analysis was restricted to singletons (n=18 942). Overall and country-level rates of stillbirth and PDNM were calculated. Multilevel logistic regression models examined the association of stillbirth and PDNM with selected risks, and the association of mother's QoL at discharge after stillbirth or PDNM. RESULTS: For women with PPH, the rate of stillbirths was 104.42 per 1000 births (n=1978) and the rate of PDNM was 15.56 per 1000 live births (n=264). Cesarean delivery, increasing blood loss, maternal complications, and maternal death were strongly associated with these adverse outcomes. Women with stillbirth and PDNM were significantly more likely to report poorer QoL. CONCLUSION: Women with PPH experience an extremely high rate of stillbirth and slightly elevated PDNM, which is associated with markers of the severity of their condition and impacts on their QoL. CI - © 2020 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Hough, Amy AU - Hough A AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Shakur-Still, Haleema AU - Shakur-Still H AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Roberts, Ian AU - Roberts I AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Koukounari, Artemis AU - Koukounari A AD - London School of Hygiene & Tropical Medicine, London, UK. FAU - Lawn, Joy E AU - Lawn JE AD - London School of Hygiene & Tropical Medicine, London, UK. CN - WOMAN Trial Collaborators LA - eng GR - London School of Hygiene & Tropical Medicine/ GR - Pfizer/ GR - DH_/Department of Health/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - GATES/Bill & Melinda Gates Foundation/United States PT - Journal Article DEP - 20201102 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Adult MH - Cesarean Section/adverse effects MH - Female MH - Humans MH - Infant MH - *Infant Mortality MH - Infant, Newborn MH - Maternal Death MH - Perinatal Death/*etiology MH - Postpartum Hemorrhage/*epidemiology MH - Pregnancy MH - Quality of Life MH - Risk Factors MH - Stillbirth/*epidemiology MH - Young Adult OTO - NOTNLM OT - Neonatal mortality OT - Postpartum hemorrhage OT - Stillbirth EDAT- 2020/10/09 06:00 MHDA- 2021/05/05 06:00 CRDT- 2020/10/08 05:35 PHST- 2020/04/12 00:00 [received] PHST- 2020/08/04 00:00 [revised] PHST- 2020/10/05 00:00 [accepted] PHST- 2020/10/09 06:00 [pubmed] PHST- 2021/05/05 06:00 [medline] PHST- 2020/10/08 05:35 [entrez] AID - 10.1002/ijgo.13413 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2021 Apr;153(1):146-153. doi: 10.1002/ijgo.13413. Epub 2020 Nov 2. PMID- 33361746 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20231110 IS - 1941-5923 (Electronic) IS - 1941-5923 (Linking) VI - 21 DP - 2020 Dec 26 TI - A Case of Lingua Villosa Nigra (Black Hairy Tongue) in a 3-Month-Old Infant. PG - e926362 LID - 10.12659/AJCR.926362 [doi] AB - BACKGROUND Black hairy tongue is a self-limiting, usually asymptomatic, benign lesion that most often affects men and people aged over 30-40 years. The lesion is extremely rare among newborns and infants. Lingua villosa nigra is characterized by the presence of elongated filiform papillae of the dorsum of the tongue, which gives a hairy appearance. The overgrown papillae can accumulate fungi, bacteria, pigments originating from food, or any other debris that can contribute to the discoloration of the tongue. The prognosis for black hairy tongue is positive. Gentle tongue brushing or scraping as well as the elimination of predisposing factors usually leads to cessation of the lesion. CASE REPORT A generally healthy, exclusively breastfed 3-month-old female baby was admitted to the Oral Pathology Department of Wrocław Medical University due to a persistent tongue lesion. Intraorally, dark, blackish, elongated tongue papillae were observed. Three weeks earlier, the baby's pediatrician had diagnosed thrush and prescribed systemic antifungal treatment with Nystatinum, without prior mycological examination. The lesion did not resolve and the girl was referred to the Department of Oral Pathology. A meticulous medical and dietary interview revealed that since the 28th day of life the baby had been supplemented with vitamin C. This, together with an intraoral examination, led to the diagnosis of black hairy tongue. The lesion disappeared partially after 4 weeks of tongue brushing. CONCLUSIONS To prevent infants from undergoing persistent and unnecessary treatment (topical or systemic drugs) or additional diagnostic procedures, such as biopsy, it is essential to be familiar with the characteristics of lingua villosa nigra as well as its origin and management. The consideration of this condition is invaluable for babies' health and safety. FAU - Owczarek-Drabińska, Joanna E AU - Owczarek-Drabińska JE AD - Department of Oral Pathology, Wrocław Medical University, Wrocław, Poland. FAU - Radwan-Oczko, Małgorzata AU - Radwan-Oczko M AD - Department of Oral Pathology, Wrocław Medical University, Wrocław, Poland. LA - eng PT - Case Reports PT - Journal Article DEP - 20201226 PL - United States TA - Am J Case Rep JT - The American journal of case reports JID - 101489566 RN - 0 (Antifungal Agents) RN - Black hairy tongue SB - IM MH - Aged MH - Antifungal Agents MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Tongue MH - *Tongue Diseases MH - *Tongue, Hairy/diagnosis PMC - PMC7774497 COIS- Conflict of interest: None declared Conflict of interest None. EDAT- 2020/12/29 06:00 MHDA- 2021/05/15 06:00 PMCR- 2020/12/26 CRDT- 2020/12/28 11:45 PHST- 2020/12/28 11:45 [entrez] PHST- 2020/12/29 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/12/26 00:00 [pmc-release] AID - 926362 [pii] AID - 10.12659/AJCR.926362 [doi] PST - epublish SO - Am J Case Rep. 2020 Dec 26;21:e926362. doi: 10.12659/AJCR.926362. PMID- 39670491 OWN - NLM STAT- Publisher LR - 20241213 IS - 2212-3946 (Electronic) IS - 1574-888X (Linking) DP - 2024 Dec 12 TI - CT-Guided Foramen Ovale Injection of Mesenchymal Stem Cells: First Human Case Report of Trigeminal Neuralgia Relief. LID - 10.2174/011574888X335230241111061649 [doi] AB - INTRODUCTION/OBJECTIVE: Trigeminal Neuralgia (TN) is an extremely painful condition without an established treatment other than symptom-suppressive medications or temporary relief from corticosteroid injections. Mesenchymal Stem Cells (MSCs) have demonstrated the ability to enhance healing and reduce inflammation and pain without side effects. Our objective was to evaluate the safety and efficacy of CT-guided foramen ovale MSC injection in the treatment of TN. METHODS: A 48-year-old woman presented with a 22-year history of severe TN. Previous treatments, including microvascular decompression, acupuncture, chiropractic adjustment, and hypnotism had failed. Medications decreased pain, but produced severe bothersome mental clouding. After proper informed consent, the patient elected trigeminal nerve injection in the foramen ovale with AlloRx (vitrobiopharma.com Golden Colorado) umbilical cord-derived Mesenchymal Stem Cells (MSCs). An experienced pain specialist with previous experience using CT guidance with sedation to inject the trigeminal nerve in the foramen ovale with corticosteroids performed the injection using 20 million MSCs. The patient reported no adverse events or complications related to the treatment. RESULTS: At 1 month post-treatment, the patient reported dramatically reduced pain/tingling, and no longer needed medication, which resulted in the resolution of her mental clouding. At 12 months post-treatment, some symptoms recurred, but the patient maintained substantial cognitive improvements and required a reduced dose of medication. CONCLUSION: We have demonstrated, for the first time, CT-guided MSC injection into the foramen ovale to result in significant improvement in trigeminal neuralgia without side effects. CI - Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Candido, Kenneth AU - Candido K AD - Advocate Illinois Masonic Medical Center, United States. FAU - Prodromos, Chadwick AU - Prodromos C AD - The Foundation for Orthopaedics and Regenerative Medicine, United States. FAU - Nenchev, Kristian AU - Nenchev K AUID- ORCID: 0009-0000-0374-9576 AD - The Foundation for Orthopaedics and Regenerative Medicine, United States. LA - eng PT - Case Reports PT - Journal Article DEP - 20241212 PL - United Arab Emirates TA - Curr Stem Cell Res Ther JT - Current stem cell research & therapy JID - 101272517 SB - IM OTO - NOTNLM OT - Mesenchymal stem cells OT - case report. OT - trigeminal neuralgia EDAT- 2024/12/13 12:27 MHDA- 2024/12/13 12:27 CRDT- 2024/12/13 06:43 PHST- 2024/06/05 00:00 [received] PHST- 2024/10/11 00:00 [revised] PHST- 2024/10/16 00:00 [accepted] PHST- 2024/12/13 12:27 [medline] PHST- 2024/12/13 12:27 [pubmed] PHST- 2024/12/13 06:43 [entrez] AID - CSCR-EPUB-144873 [pii] AID - 10.2174/011574888X335230241111061649 [doi] PST - aheadofprint SO - Curr Stem Cell Res Ther. 2024 Dec 12. doi: 10.2174/011574888X335230241111061649. PMID- 11107710 OWN - NLM STAT- MEDLINE DCOM- 20010215 LR - 20181130 IS - 8750-7315 (Print) IS - 1930-8264 (Linking) VI - 90 IP - 10 DP - 2000 Nov-Dec TI - Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States. PG - 495-501 AB - Ciclopirox 8% nail lacquer has recently become the first topical antifungal agent to be approved by the US Food and Drug Administration for the treatment of onychomycosis. This article reviews the results of the two pivotal clinical trials of this drug that have been performed in the United States as well as those that have been carried out in other countries. The two US studies were both double-blind, vehicle-controlled, parallel-group, multicenter studies designed to determine the efficacy and safety of ciclopirox nail lacquer in the treatment of mild-to-moderate onychomycosis of the toenails caused by dermatophytes. The combined results show a 34% mycologic cure rate, as compared with 10% for the placebo. Data from the ten studies conducted worldwide show a meta-analytic mean (+/- SE) mycologic cure rate of 52.6% +/- 4.2%. As expected for a topical agent, ciclopirox nail lacquer was found to be extremely safe, with mild, transient irritation at the site of application reported as the most common adverse event. Ciclopirox nail lacquer may also have potential for use in combination or adjunctive therapy. Further studies will help to better position this agent for the treatment of this widespread podiatric condition. FAU - Gupta, A K AU - Gupta AK AD - Department of Medicine, Sunnybrook and Women's College Health Sciences Center (Sunnybrook Site), Toronto, Ontario, Canada. agupta@execulink.com FAU - Joseph, W S AU - Joseph WS LA - eng PT - Clinical Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Am Podiatr Med Assoc JT - Journal of the American Podiatric Medical Association JID - 8501423 RN - 0 (Antifungal Agents) RN - 0 (Pyridones) RN - 19W019ZDRJ (Ciclopirox) SB - IM MH - Administration, Topical MH - Adolescent MH - Adult MH - Aged MH - Antifungal Agents/*therapeutic use MH - Ciclopirox MH - Double-Blind Method MH - Female MH - Foot Dermatoses/drug therapy MH - Humans MH - Male MH - Middle Aged MH - Multicenter Studies as Topic MH - Onychomycosis/*drug therapy MH - Podiatry MH - Pyridones/*therapeutic use MH - United States EDAT- 2000/12/07 11:00 MHDA- 2001/03/03 10:01 CRDT- 2000/12/07 11:00 PHST- 2000/12/07 11:00 [pubmed] PHST- 2001/03/03 10:01 [medline] PHST- 2000/12/07 11:00 [entrez] AID - 10.7547/87507315-90-10-495 [doi] PST - ppublish SO - J Am Podiatr Med Assoc. 2000 Nov-Dec;90(10):495-501. doi: 10.7547/87507315-90-10-495. PMID- 38526526 OWN - NLM STAT- MEDLINE DCOM- 20240326 LR - 20240411 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 11 DP - 2024 Mar 25 TI - Safety in Teletriage by Nurses and Physicians in the United States and Israel: Narrative Review and Qualitative Study. PG - e50676 LID - 10.2196/50676 [doi] LID - e50676 AB - BACKGROUND: The safety of telemedicine in general and telephone triage (teletriage) safety in particular have been a focus of concern since the 1970s. Today, telehealth, now subsuming teletriage, has a basic structure and process intended to promote safety. However, inadequate telehealth systems may also compromise patient safety. The COVID-19 pandemic accelerated rapid but uneven telehealth growth, both technologically and professionally. Within 5-10 years, the field will likely be more technologically advanced; however, these advances may still outpace professional standards. The need for an evidence-based system is crucial and urgent. OBJECTIVE: Our aim was to explore ways that developed teletriage systems produce safe outcomes by examining key system components and questioning long-held assumptions. METHODS: We examined safety by performing a narrative review of the literature using key terms concerning patient safety in teletriage. In addition, we conducted system analysis of 2 typical formal systems, physician led and nurse led, in Israel and the United States, respectively, and evaluated those systems' respective approaches to safety. Additionally, we conducted in-depth interviews with representative physicians and 1 nurse using a qualitative approach. RESULTS: The review of literature indicated that research on various aspects of telehealth and teletriage safety is still sparse and of variable quality, producing conflicting and inconsistent results. Researchers, possibly unfamiliar with this complicated field, use an array of poorly defined terms and appear to design studies based on unfounded assumptions. The interviews with health care professionals demonstrated several challenges encountered during teletriage, mainly making diagnosis from a distance, treating unfamiliar patients, a stressful atmosphere, working alone, and technological difficulties. However, they reported using several measures that help them make accurate diagnoses and reasonable decisions, thus keeping patient safety, such as using their expertise and intuition, using structured protocols, and considering nonmedical factors and patient preferences (shared decision-making). CONCLUSIONS: Remote encounters about acute, worrisome symptoms are time sensitive, requiring decision-making under conditions of uncertainty and urgency. Patient safety and safe professional practice are extremely important in the field of teletriage, which has a high potential for error. This underregulated subspecialty lacks adequate development and substantive research on system safety. Research may commingle terminology and widely different, ill-defined groups of decision makers with wide variation in decision-making skills, clinical training, experience, and job qualifications, thereby confounding results. The rapid pace of telehealth's technological growth creates urgency in identifying safe systems to guide developers and clinicians about needed improvements. CI - ©Motti Haimi, Sheila Quilter Wheeler. Originally published in JMIR Human Factors (https://humanfactors.jmir.org), 25.03.2024. FAU - Haimi, Motti AU - Haimi M AUID- ORCID: 0000-0001-8751-9793 AD - Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. AD - Health Systems Management Department, The Max Stern Yezreel Valley College, Emek Yezreel, Israel. AD - Meuhedet Healthcare Services - North District, Tel Aviv, Israel. FAU - Wheeler, Sheila Quilter AU - Wheeler SQ AUID- ORCID: 0009-0008-9477-6825 AD - TeleTriage Systems, San Anselmo, CA, United States. LA - eng PT - Journal Article PT - Review DEP - 20240325 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - United States MH - Israel MH - *Pandemics/prevention & control MH - *Physicians MH - Health Personnel MH - Qualitative Research PMC - PMC11002740 OTO - NOTNLM OT - human error OT - outcome OT - patient safety OT - safety OT - system error OT - telehealth OT - telemedicine OT - telephone triage OT - teletriage OT - triage COIS- Conflicts of Interest: None declared. EDAT- 2024/03/25 12:45 MHDA- 2024/03/26 06:44 PMCR- 2024/03/25 CRDT- 2024/03/25 11:53 PHST- 2023/07/09 00:00 [received] PHST- 2024/02/28 00:00 [accepted] PHST- 2023/11/25 00:00 [revised] PHST- 2024/03/26 06:44 [medline] PHST- 2024/03/25 12:45 [pubmed] PHST- 2024/03/25 11:53 [entrez] PHST- 2024/03/25 00:00 [pmc-release] AID - v11i1e50676 [pii] AID - 10.2196/50676 [doi] PST - epublish SO - JMIR Hum Factors. 2024 Mar 25;11:e50676. doi: 10.2196/50676. PMID- 23929092 OWN - NLM STAT- MEDLINE DCOM- 20131118 LR - 20211021 IS - 1535-7228 (Electronic) IS - 0002-953X (Print) IS - 0002-953X (Linking) VI - 170 IP - 10 DP - 2013 Oct TI - Response to learned threat: An FMRI study in adolescent and adult anxiety. PG - 1195-204 LID - 10.1176/appi.ajp.2013.12050651 [doi] AB - OBJECTIVE: Poor threat-safety discrimination reflects prefrontal cortex dysfunction in adult anxiety disorders. While adolescent anxiety disorders are impairing and predict high risk for adult anxiety disorders, the neural correlates of threat-safety discrimination have not been investigated in this population. The authors compared prefrontal cortex function in anxious and healthy adolescents and adults following conditioning and extinction, processes requiring threat-safety learning. METHOD: Anxious and healthy adolescents and adults (N=114) completed fear conditioning and extinction in the clinic. The conditioned stimuli (CS+) were neutral faces, paired with an aversive scream. Physiological and subjective data were acquired. Three weeks later, 82 participants viewed the CS+ and morphed images resembling the CS+ in an MRI scanner. During scanning, participants made difficult threat-safety discriminations while appraising threat and explicit memory of the CS+. RESULTS: During conditioning and extinction, the anxious groups reported more fear than the healthy groups, but the anxious adolescent and adult groups did not differ on physiological measures. During imaging, both anxious adolescents and adults exhibited lower activation in the subgenual anterior cingulate cortex than their healthy counterparts, specifically when appraising threat. Compared with their age-matched counterpart groups, anxious adults exhibited reduced activation in the ventromedial prefrontal cortex when appraising threat, whereas anxious adolescents exhibited a U-shaped pattern of activation, with greater activation in response to the most extreme CS+ and CS-. CONCLUSIONS: Two regions of the prefrontal cortex are involved in anxiety disorders. Reduced subgenual anterior cingulate cortex engagement is a shared feature in adult and adolescent anxiety disorders, but ventromedial prefrontal cortex dysfunction is age-specific. The unique U-shaped pattern of activation in the ventromedial prefrontal cortex in many anxious adolescents may reflect heightened sensitivity to threat and safety conditions. How variations in the pattern relate to later risk for adult illness remains to be determined. FAU - Britton, Jennifer C AU - Britton JC FAU - Grillon, Christian AU - Grillon C FAU - Lissek, Shmuel AU - Lissek S FAU - Norcross, Maxine A AU - Norcross MA FAU - Szuhany, Kristin L AU - Szuhany KL FAU - Chen, Gang AU - Chen G FAU - Ernst, Monique AU - Ernst M FAU - Nelson, Eric E AU - Nelson EE FAU - Leibenluft, Ellen AU - Leibenluft E FAU - Shechner, Tomer AU - Shechner T FAU - Pine, Daniel S AU - Pine DS LA - eng GR - K99 MH091183/MH/NIMH NIH HHS/United States GR - R00 MH091183/MH/NIMH NIH HHS/United States GR - Z99 MH999999/Intramural NIH HHS/United States GR - K99-MH-091183/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PL - United States TA - Am J Psychiatry JT - The American journal of psychiatry JID - 0370512 SB - IM MH - Adolescent MH - Adult MH - Anxiety Disorders/diagnosis/*physiopathology/psychology MH - Arousal/*physiology MH - Brain Mapping MH - Conditioning, Classical/*physiology MH - Discrimination, Psychological MH - Extinction, Psychological/physiology MH - Facial Expression MH - Fear/*physiology MH - Female MH - Humans MH - *Image Interpretation, Computer-Assisted MH - *Magnetic Resonance Imaging MH - Male MH - Mental Recall/physiology MH - Pattern Recognition, Visual/physiology MH - Prefrontal Cortex/*physiopathology MH - Young Adult PMC - PMC3790858 MID - NIHMS474482 COIS- Disclosures All authors report no competing interests. EDAT- 2013/08/10 06:00 MHDA- 2013/11/19 06:00 PMCR- 2014/10/01 CRDT- 2013/08/10 06:00 PHST- 2013/08/10 06:00 [entrez] PHST- 2013/08/10 06:00 [pubmed] PHST- 2013/11/19 06:00 [medline] PHST- 2014/10/01 00:00 [pmc-release] AID - 1725885 [pii] AID - 10.1176/appi.ajp.2013.12050651 [doi] PST - ppublish SO - Am J Psychiatry. 2013 Oct;170(10):1195-204. doi: 10.1176/appi.ajp.2013.12050651. PMID- 38043474 OWN - NLM STAT- MEDLINE DCOM- 20240110 LR - 20240116 IS - 1879-3460 (Electronic) IS - 0168-1605 (Linking) VI - 411 DP - 2024 Feb 2 TI - Challenges for estimating human norovirus infectivity by viability RT-qPCR as compared to replication in human intestinal enteroids. PG - 110507 LID - S0168-1605(23)00424-5 [pii] LID - 10.1016/j.ijfoodmicro.2023.110507 [doi] AB - Viability RT-qPCR, a molecular detection method combining viability marker pre-treatment with RT-qPCR, has been proposed to infer infectivity of viruses which is particularly relevant for non-culturable viruses or sophisticated cell culture systems. Being human noroviruses (HuNoV) most frequently associated with foodborne outbreaks, this study compared different viability techniques and infectivity in human intestinal enteroids (HIE) to ultimately determine whether the molecular approaches could serve as rapid assays to predict HuNoV inactivation in high-risk food. To this end, the performance of three viability RT-qPCR assays with different intercalating markers ((Viability PCR Crosslinker Kit (CL), propidium monoazide (PMAxx™), and platinum chloride (PtCl(4))) in estimating survival of HuNoV exposed to thermal and high pressure (HPP) treatments was compared to replication tested in the HIE cell culture model. A nearly full-length genomic molecular assay coupled with PMAxx™ to infer HuNoV thermal inactivation was also assessed. The experimental design included HuNoV genogroup I.3 [P13], GII.4 Sydney [P16], GII.6 [P7], along with Tulane virus (TV) serving as surrogate. Finally, viability RT-qPCR was tested in HPP-treated strawberry puree, selected as a food matrix with high viral contamination risk. PMAxx™ and CL performed evenly, while PtCl(4) affected HuNoV infectivity. Taking all experimental data together, viability RT-qPCR was demonstrated to be an improved method over direct RT-qPCR to estimate viral inactivation at extreme thermal (95 °C) and HPP (450 MPa) exposures, but not under milder conditions as amplification signals were detected. Despite its complexity and limitations, the HIE demonstrated a more robust model than viability RT-qPCR to assess HuNoV infectivity. CI - Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wales, Samantha Q AU - Wales SQ AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD, United States. FAU - Pandiscia, Annamaria AU - Pandiscia A AD - Department of Preservation and Food Safety Technologies, Institute of Agrochemistry and Food Technology, IATA-CSIC, Avda. Catedrático Agustín Escardino 7, Valencia, Paterna 46980, Spain; Department of Veterinary Medicine, University of Bari, Provincial Road to Casamassima Km 3, Bari, Valenzano 70010, Italy. FAU - Kulka, Michael AU - Kulka M AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD, United States. FAU - Sanchez, Gloria AU - Sanchez G AD - Department of Preservation and Food Safety Technologies, Institute of Agrochemistry and Food Technology, IATA-CSIC, Avda. Catedrático Agustín Escardino 7, Valencia, Paterna 46980, Spain. FAU - Randazzo, Walter AU - Randazzo W AD - Department of Preservation and Food Safety Technologies, Institute of Agrochemistry and Food Technology, IATA-CSIC, Avda. Catedrático Agustín Escardino 7, Valencia, Paterna 46980, Spain. Electronic address: wrandazzo@iata.csic.es. LA - eng PT - Journal Article DEP - 20231124 PL - Netherlands TA - Int J Food Microbiol JT - International journal of food microbiology JID - 8412849 SB - IM MH - Humans MH - Real-Time Polymerase Chain Reaction/methods MH - *Norovirus/genetics MH - Intestines MH - *Caliciviridae Infections MH - Virus Inactivation OTO - NOTNLM OT - Cell culture OT - Food safety OT - Molecular methods COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/12/04 00:42 MHDA- 2024/01/10 06:42 CRDT- 2023/12/03 18:14 PHST- 2023/08/22 00:00 [received] PHST- 2023/11/17 00:00 [revised] PHST- 2023/11/20 00:00 [accepted] PHST- 2024/01/10 06:42 [medline] PHST- 2023/12/04 00:42 [pubmed] PHST- 2023/12/03 18:14 [entrez] AID - S0168-1605(23)00424-5 [pii] AID - 10.1016/j.ijfoodmicro.2023.110507 [doi] PST - ppublish SO - Int J Food Microbiol. 2024 Feb 2;411:110507. doi: 10.1016/j.ijfoodmicro.2023.110507. Epub 2023 Nov 24. PMID- 34399240 OWN - NLM STAT- MEDLINE DCOM- 20211018 LR - 20211018 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 157 DP - 2021 Dec TI - The decay of airborne bacteria and fungi in a constant temperature and humidity test chamber. PG - 106816 LID - S0160-4120(21)00441-4 [pii] LID - 10.1016/j.envint.2021.106816 [doi] AB - Despite substantial research to profile the microbial characteristics in the atmosphere, the changing metabolism underpinning microbial successional dynamics remains ambiguous. Herein, we applied qPCR, high-throughput sequencing of the genes encoding 16S and ITS rRNA to render the bacterial/fungal dynamics of ambient PM(2.5) filters maintained at constant conditions of temperature (20 ± 2 °C) and humidity (50 ± 5%). The incubation experiments which lasted for 50 days aim to simulate a metabolic process of microbe in two types PM(2.5) (polluted and non-polluted). The results show that microbial community species in polluted PM(2.5) had faster decay rates, more bacterial diversity and less fungal community compared to the non-polluted ones. For bacteria, the proportion of anaerobic species is higher than aerobic ones, and their performance of contain mobile elements, form-biofilms, and pathogenic risks declined rapidly as times went by. Whereas for fungi, saprotroph species occupied about 70% of the population, resulting in a specified peak of abundance due to the adequacy nutrients supplied by the apoptosis cells. Combining the classified microbial species, we found stable community structure and the volatile ones related to the various metabolic survival strategies during different time. Without the input of peripheral environment, the health risks of airborne microbe descend to a healthy level after 20 days, implying their biologic effectiveness was about 20 days no matter the air is polluted or not. This study provided new insights into the different metabolic survival of airborne microorganisms in ideal and stable conditions. CI - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Xu, Caihong AU - Xu C AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China. FAU - Chen, Hui AU - Chen H AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China. FAU - Liu, Zhe AU - Liu Z AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China. FAU - Sui, Guodong AU - Sui G AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China. FAU - Li, Dan AU - Li D AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China. FAU - Kan, Haidong AU - Kan H AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Zhao, Zhuohui AU - Zhao Z AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China. FAU - Hu, Wei AU - Hu W AD - School of Earth System Science, Tianjin University, Tianjin 300072, China. FAU - Chen, Jianmin AU - Chen J AD - Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP(3)), Department of Environmental Science & Engineering, Fudan Tyndall Centre, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Institute of Atmospheric Sciences, Fudan University, Shanghai 200438, China; Institute of Eco-Chongming (IEC), Shanghai 200062, China. Electronic address: jmchen@fudan.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210813 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Air Pollutants) RN - 0 (Particulate Matter) SB - IM MH - Air Microbiology MH - *Air Pollutants/analysis MH - Bacteria/genetics MH - Environmental Monitoring MH - Fungi/genetics MH - Humidity MH - *Particulate Matter/analysis MH - Seasons MH - Temperature OTO - NOTNLM OT - Airborne bacteria OT - Bioaerosol OT - Decay OT - Function OT - PM(2.5) EDAT- 2021/08/17 06:00 MHDA- 2021/10/21 06:00 CRDT- 2021/08/16 20:16 PHST- 2021/03/05 00:00 [received] PHST- 2021/08/02 00:00 [revised] PHST- 2021/08/03 00:00 [accepted] PHST- 2021/08/17 06:00 [pubmed] PHST- 2021/10/21 06:00 [medline] PHST- 2021/08/16 20:16 [entrez] AID - S0160-4120(21)00441-4 [pii] AID - 10.1016/j.envint.2021.106816 [doi] PST - ppublish SO - Environ Int. 2021 Dec;157:106816. doi: 10.1016/j.envint.2021.106816. Epub 2021 Aug 13. PMID- 29378130 OWN - NLM STAT- MEDLINE DCOM- 20180312 LR - 20180312 IS - 1520-5118 (Electronic) IS - 0021-8561 (Linking) VI - 66 IP - 8 DP - 2018 Feb 28 TI - Alcalase Enzymolysis of Red Bean (adzuki) Ferritin Achieves Nanoencapsulation of Food Nutrients in a Mild Condition. PG - 1999-2007 LID - 10.1021/acs.jafc.7b05656 [doi] AB - Classical methods to fabricate ferritin-nutrients shell-core nanoparticles usually apply extremely acid/alkaline pH transition, which may cause the activity loss of nutrients or the formation of insoluble aggregates. In this work, we prepared an extension peptide (EP) deleted red bean (adzuki) ferritin (apoRBFΔEP) by Alcalase 3.0T enzymolysis. Such enzymolysis could delete the EP domain and remain the typical shell-like structure of the ferritin. Meanwhile, the α-helix content of apoRBFΔEP was decreased by 5.5%, and the transition temperature (T(m)) was decreased by 4.1 °C. Interestingly, the apoRBFΔEP can be disassembled into subunits under a benign condition at pH 4.0 and is assembled to form an intact cage protein when the pH was increased to 6.7. By using this novel route, the epigallocatechin gallate (EGCG) molecules were successfully encapsulated into the apoRBFΔEP cage with an encapsulation ratio of 11.6% (w/w), which was comparable with that by the traditional pH 2.0 transition. The newly prepared EGCG-loaded apoRBFΔEP exhibited a similarly protective effect on the EGCG upon simulated gastrointestinal tract and thermal treatment as compared with the control. In addition, the EGCG-loaded apoRBFΔEP could significantly relieve the ferritin association induced by pH transition, which was superior to traditional method. The thinking of this work will be especially suitable for encapsulating pH-sensitive molecules based on ferritin in a benign condition. FAU - Yang, Rui AU - Yang R AUID- ORCID: 0000-0002-7281-7672 AD - State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology , Tianjin 300457, People's Republic of China. AD - Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU) , Beijing 100048, People's Republic of China. FAU - Liu, Yuqian AU - Liu Y AD - State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology , Tianjin 300457, People's Republic of China. FAU - Meng, Demei AU - Meng D AD - State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology , Tianjin 300457, People's Republic of China. FAU - Blanchard, Christopher L AU - Blanchard CL AD - ARC Industrial Transformation Training Centre for Functional Grains , Wagga Wagga New South Wales 2678, Australia. FAU - Zhou, Zhongkai AU - Zhou Z AD - State Key Laboratory of Food Nutrition and Safety, College of Food Engineering and Biotechnology, Tianjin University of Science and Technology , Tianjin 300457, People's Republic of China. LA - eng PT - Journal Article DEP - 20180215 PL - United States TA - J Agric Food Chem JT - Journal of agricultural and food chemistry JID - 0374755 RN - 0 (Plant Proteins) RN - 9007-73-2 (Ferritins) RN - EC 3.4.21.- (Subtilisins) SB - IM MH - Biocatalysis MH - Fabaceae/*chemistry MH - Ferritins/*chemistry MH - Hydrogen-Ion Concentration MH - Nanoparticles/chemistry MH - Plant Proteins/*chemistry MH - Subtilisins/*chemistry OTO - NOTNLM OT - alcalase OT - enzymolysis OT - ferritin OT - food nutrients OT - shell−core nanoparticle EDAT- 2018/01/30 06:00 MHDA- 2018/03/13 06:00 CRDT- 2018/01/30 06:00 PHST- 2018/01/30 06:00 [pubmed] PHST- 2018/03/13 06:00 [medline] PHST- 2018/01/30 06:00 [entrez] AID - 10.1021/acs.jafc.7b05656 [doi] PST - ppublish SO - J Agric Food Chem. 2018 Feb 28;66(8):1999-2007. doi: 10.1021/acs.jafc.7b05656. Epub 2018 Feb 15. PMID- 38867858 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240614 IS - 1520-765X (Print) IS - 1554-2815 (Electronic) IS - 1520-765X (Linking) VI - 26 IP - Suppl 1 DP - 2024 Apr TI - There are those who would like zero LDL cholesterol. PG - i19-i22 LID - 10.1093/eurheartjsupp/suae012 [doi] AB - The overwhelming evidence that the reduction of LDL cholesterol (LDLc) levels is associated with a parallel reduction in cardiovascular (CV) risk has led the scientific community to progressively and constantly reduce the optimal therapeutic targets of LDLc, both in patients with known CV disease and in patients undergoing primary prevention. The recent introduction of proprotein convertase subtilisin/kexin type 9 inhibitors has allowed clinicians to observe reductions in LDLc levels that go well beyond the limits set by the main international guidelines; following the 'the lower the better' paradigm, it is natural to ask how low LDLc can be reduced, whether this intervention is associated with a further reduction in CV risk and, above all, whether there are no issues related to safety in the use of polypharmacotherapies that determine an extreme reduction in LDLc levels. The purpose of this article is to summarize the main scientific evidence on the topic, trying to provide an answer to all clinicians who 'would like their LDLc to be-almost-zero'. CI - © The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Borghi, Claudio AU - Borghi C AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna. FAU - Bragagni, Alessio AU - Bragagni A AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna. LA - eng PT - Journal Article DEP - 20240417 PL - England TA - Eur Heart J Suppl JT - European heart journal supplements : journal of the European Society of Cardiology JID - 100886647 PMC - PMC11167977 OTO - NOTNLM OT - Cardiovascular risk OT - Dyslipidaemia OT - Ezetimibe OT - LDL cholesterol OT - PCSK9 inhibitors OT - Statins COIS- Conflict of interest: none declared. EDAT- 2024/06/13 06:44 MHDA- 2024/06/13 06:45 PMCR- 2024/04/17 CRDT- 2024/06/13 04:25 PHST- 2024/06/13 06:45 [medline] PHST- 2024/06/13 06:44 [pubmed] PHST- 2024/06/13 04:25 [entrez] PHST- 2024/04/17 00:00 [pmc-release] AID - suae012 [pii] AID - 10.1093/eurheartjsupp/suae012 [doi] PST - epublish SO - Eur Heart J Suppl. 2024 Apr 17;26(Suppl 1):i19-i22. doi: 10.1093/eurheartjsupp/suae012. eCollection 2024 Apr. PMID- 27764178 OWN - NLM STAT- MEDLINE DCOM- 20170613 LR - 20221207 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 10 DP - 2016 TI - Multi-Country Evaluation of Safety of Dihydroartemisinin/Piperaquine Post-Licensure in African Public Hospitals with Electrocardiograms. PG - e0164851 LID - 10.1371/journal.pone.0164851 [doi] LID - e0164851 AB - The antimalarial drug piperaquine is associated with delayed ventricular depolarization, causing prolonged QT interval (time taken for ventricular de-polarisation and re-polarisation). There is a lack of safety data regarding dihydroartemisinin/piperaquine (DHA/PPQ) for the treatment of uncomplicated malaria, which has limited its use. We created a platform where electrocardiograms (ECG) were performed in public hospitals for the safety assessment of DHA/PPQ, at baseline before the use of dihydroartemisinin/piperaquine (Eurartesim®), and on day 3 (before and after administration of the final dose) and day 7 post-administration. Laboratory analyses included haematology and clinical chemistry. The main objective of the ECG assessment in this study was to evaluate the effect of administration of DHA/PPQ on QTc intervals and the association of QTc intervals with changes in blood biochemistry, full and differential blood count over time after the DHA/PPQ administration. A total of 1315 patients gave consent and were enrolled of which 1147 (87%) had complete information for analyses. Of the enrolled patients 488 (42%), 323 (28%), 213 (19%) and 123 (11%) were from Ghana, Burkina Faso, Tanzania and Mozambique, respectively. Median (lower-upper quartile) age was 8 (5-14) years and a quarter of the patients were children under five years of age (n = 287). Changes in blood biochemistry, full and differential blood count were temporal which remained within clinical thresholds and did not require any intervention. The mean QTcF values were significantly higher than on day 1 when measured on day 3 before and after administration of the treatment as well as on day 7, four days after completion of treatment (12, 22 and 4 higher, p < 0.001). In all age groups the values of QT, QTcF and QTcB were highest on day 3 after drug intake. The mean extreme QTcF prolongation from baseline was lowest on day 3 before drug intake (33 ms, SD = 19) and highest on day 3 after the last dose (60 ms, SD = 31). There were 79 (7%) events of extreme mean QTcF prolongation which were not clinically significant. Nearly a half of them (n = 37) were grade 3 and mainly among males (33/37). Patients in Burkina Faso, Mozambique and Tanzania had significantly lower mean QTcF than patients in Ghana by an average of 3, 4 and 11 ms, respectively. We found no evidence that Eurartesim® administered in therapeutic doses in patients with uncomplicated malaria and no predisposing cardiac conditions in Africa was associated with adverse clinically significant QTc prolongation. FAU - Kabanywanyi, Abdunoor M AU - Kabanywanyi AM AUID- ORCID: 0000-0002-2980-0429 AD - Ifakara Health Institute, Dar es Salaam, Tanzania. FAU - Baiden, Rita AU - Baiden R AD - INDEPTH Network, Accra, Ghana. FAU - Ali, Ali M AU - Ali AM AD - Ifakara Health Institute, Dar es Salaam, Tanzania. FAU - Mahende, Muhidin K AU - Mahende MK AD - Ifakara Health Institute, Dar es Salaam, Tanzania. FAU - Ogutu, Bernhards R AU - Ogutu BR AD - INDEPTH Network, Accra, Ghana. FAU - Oduro, Abraham AU - Oduro A AD - Navrongo Health Research Centre, Navrongo, Ghana. FAU - Tinto, Halidou AU - Tinto H AD - Nanoro Health Research Centre, Nanoro, Burkina Faso. FAU - Gyapong, Margaret AU - Gyapong M AD - Dodowa Health Research Centre, Dodowa, Ghana. FAU - Sie, Ali AU - Sie A AD - Nouna Health Research Centre, Nouna, Burkina Faso. FAU - Sevene, Esperanca AU - Sevene E AD - Centro de Investigaçãoem Saúde de Manhiça(CISM), Manhiça, Mozambique. FAU - Macete, Eusebio AU - Macete E AD - Centro de Investigaçãoem Saúde de Manhiça(CISM), Manhiça, Mozambique. FAU - Owusu-Agyei, Seth AU - Owusu-Agyei S AD - Kintampo Health Research Centre, Kintampo, Ghana. FAU - Adjei, Alex AU - Adjei A AD - Dodowa Health Research Centre, Dodowa, Ghana. FAU - Compaoré, Guillaume AU - Compaoré G AD - Nouna Health Research Centre, Nouna, Burkina Faso. FAU - Valea, Innocent AU - Valea I AD - Nanoro Health Research Centre, Nanoro, Burkina Faso. FAU - Osei, Isaac AU - Osei I AD - Navrongo Health Research Centre, Navrongo, Ghana. FAU - Yawson, Abena AU - Yawson A AD - Kintampo Health Research Centre, Kintampo, Ghana. FAU - Adjuik, Martin AU - Adjuik M AD - INDEPTH Network, Accra, Ghana. FAU - Akparibo, Raymond AU - Akparibo R AD - INDEPTH Network, Accra, Ghana. FAU - Kakolwa, Mwaka A AU - Kakolwa MA AD - Ifakara Health Institute, Dar es Salaam, Tanzania. FAU - Abdulla, Salim AU - Abdulla S AD - Ifakara Health Institute, Dar es Salaam, Tanzania. FAU - Binka, Fred AU - Binka F AD - University for Health and Allied Sciences, Ho, Ghana. LA - eng PT - Journal Article DEP - 20161020 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Antimalarials) RN - 0 (Artemisinins) RN - 0 (Quinolines) RN - 6A9O50735X (artenimol) RN - A0HV2Q956Y (piperaquine) SB - IM MH - Adolescent MH - Adult MH - Antimalarials/metabolism/*pharmacology/therapeutic use MH - Artemisinins/metabolism/*pharmacology/therapeutic use MH - Black People MH - Blood Cell Count MH - Blood Chemical Analysis MH - Burkina Faso MH - Child MH - Child, Preschool MH - Data Interpretation, Statistical MH - Electrocardiography MH - Female MH - Ghana MH - Heart/diagnostic imaging/*drug effects MH - Hospitals, Public MH - Humans MH - Malaria/drug therapy MH - Male MH - Mozambique MH - Quinolines/metabolism/*pharmacology/therapeutic use MH - Tanzania MH - Ventricular Dysfunction/etiology MH - Young Adult PMC - PMC5072600 COIS- The authors have declared that no competing interests exist. EDAT- 2016/10/21 06:00 MHDA- 2017/06/14 06:00 PMCR- 2016/10/20 CRDT- 2016/10/21 06:00 PHST- 2015/08/19 00:00 [received] PHST- 2016/09/28 00:00 [accepted] PHST- 2016/10/21 06:00 [pubmed] PHST- 2017/06/14 06:00 [medline] PHST- 2016/10/21 06:00 [entrez] PHST- 2016/10/20 00:00 [pmc-release] AID - PONE-D-15-32365 [pii] AID - 10.1371/journal.pone.0164851 [doi] PST - epublish SO - PLoS One. 2016 Oct 20;11(10):e0164851. doi: 10.1371/journal.pone.0164851. eCollection 2016. PMID- 36535565 OWN - NLM STAT- MEDLINE DCOM- 20230224 LR - 20240210 IS - 1569-8041 (Electronic) IS - 0923-7534 (Linking) VI - 34 IP - 3 DP - 2023 Mar TI - Durvalumab with or without tremelimumab versus the EXTREME regimen as first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck: KESTREL, a randomized, open-label, phase III study. PG - 262-274 LID - S0923-7534(22)04778-0 [pii] LID - 10.1016/j.annonc.2022.12.008 [doi] AB - BACKGROUND: Patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) have a poor prognosis. The phase III KESTREL study evaluated the efficacy of durvalumab [programmed death-ligand 1 (PD-L1) antibody] with or without tremelimumab [cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibody], versus the EXTREME regimen in patients with R/M HNSCC. PATIENTS AND METHODS: Patients with HNSCC who had not received prior systemic treatment for R/M disease were randomized (2 : 1 : 1) to receive durvalumab 1500 mg every 4 weeks (Q4W) plus tremelimumab 75 mg Q4W (up to four doses), durvalumab monotherapy 1500 mg Q4W, or the EXTREME regimen (platinum, 5-fluorouracil, and cetuximab) until disease progression. Durvalumab efficacy, with or without tremelimumab, versus the EXTREME regimen in patients with PD-L1-high tumors and in all randomized patients was assessed. Safety was also assessed. RESULTS: Durvalumab and durvalumab plus tremelimumab were not superior to EXTREME for overall survival (OS) in patients with PD-L1-high expression [median, 10.9 and 11.2 versus 10.9 months, respectively; hazard ratio (HR) = 0.96; 95% confidence interval (CI) 0.69-1.32; P = 0.787 and HR = 1.05; 95% CI 0.80-1.39, respectively]. Durvalumab and durvalumab plus tremelimumab prolonged duration of response versus EXTREME (49.3% and 48.1% versus 9.8% of patients remaining in response at 12 months), correlating with long-term OS for responding patients; however, median progression-free survival was longer with EXTREME (2.8 and 2.8 versus 5.4 months). Exploratory analyses suggested that subsequent immunotherapy use by 24.3% of patients in the EXTREME regimen arm contributed to the similar OS outcomes between arms. Grade 3/4 treatment-related adverse events (TRAEs) for durvalumab, durvalumab plus tremelimumab, and EXTREME were 8.9%, 19.1%, and 53.1%, respectively. CONCLUSIONS: In patients with PD-L1-high expression, OS was comparable between durvalumab and the EXTREME regimen. Durvalumab alone, and with tremelimumab, demonstrated durable responses and reduced TRAEs versus the EXTREME regimen in R/M HNSCC. CI - Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Psyrri, A AU - Psyrri A AD - Department of Internal Medicine, Section of Medical Oncology, Attikon University Hospital, National Kapodistrian University of Athens, Athens, Greece. Electronic address: Psyrri237@yahoo.com. FAU - Fayette, J AU - Fayette J AD - Centre de Lutte Contre le Cancer Léon Bérard, Lyon-I University, Lyon, France. FAU - Harrington, K AU - Harrington K AD - Division of Radiotherapy and Imaging, The Royal Marsden/The Institute of Cancer Research NIHR Biomedical Research Centre, London, UK. FAU - Gillison, M AU - Gillison M AD - Department of Thoracic Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, USA. FAU - Ahn, M-J AU - Ahn MJ AD - Division of Hematology-Oncology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea. FAU - Takahashi, S AU - Takahashi S AD - Department of Medical Oncology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan. FAU - Weiss, J AU - Weiss J AD - Division of Oncology, Department of Medicine, Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill, USA. FAU - Machiels, J-P AU - Machiels JP AD - Department of Medical Oncology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Brussels; Institute for Experimental and Clinical Research (IREC, pôle MIRO), Université Catholique de Louvain (UCLouvain), Brussels, Belgium. FAU - Baxi, S AU - Baxi S AD - Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. FAU - Vasilyev, A AU - Vasilyev A AD - Department of General Physiology, Saint Petersburg State University, Saint Petersburg. FAU - Karpenko, A AU - Karpenko A AD - Department of Oncology, Leningrad Regional Oncology Dispensary, Saint Petersburg. FAU - Dvorkin, M AU - Dvorkin M AD - Budgetary Institution of Healthcare, Omsk Regional Oncology Dispensary, Omsk, Russian Federation. FAU - Hsieh, C-Y AU - Hsieh CY AD - Division of Hematology & Oncology, Department of Internal Medicine, China Medical University Hospital, Taichung City, Taiwan. FAU - Thungappa, S C AU - Thungappa SC AD - Department of Medical Oncology, Healthcare Global Enterprises Limited, Bengaluru, Karnataka, India. FAU - Segura, P P AU - Segura PP AD - Servicio de Oncología Médica, Hospital Clínico San Carlos, Madrid, Spain. FAU - Vynnychenko, I AU - Vynnychenko I AD - Sumy Regional Clinical Oncology Dispensary, Sumy State University, Sumy, Ukraine. FAU - Haddad, R AU - Haddad R AD - Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA. FAU - Kasper, S AU - Kasper S AD - Department of Medical Oncology, West German Cancer Center, University Hospital, Essen. FAU - Mauz, P-S AU - Mauz PS AD - Department of Otolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany. FAU - Baker, V AU - Baker V AD - Oncology R&D, Late-Stage Development, AstraZeneca, Cambridge, UK. FAU - He, P AU - He P AD - Statistics, AstraZeneca, Gaithersburg, USA. FAU - Evans, B AU - Evans B AD - Statistics, AstraZeneca, Gaithersburg, USA. FAU - Wildsmith, S AU - Wildsmith S AD - Oncology R&D, Late-Stage Development, AstraZeneca, Cambridge, UK. FAU - Olsson, R F AU - Olsson RF AD - Oncology R&D, Late-Stage Development, AstraZeneca, Gothenburg, Sweden. FAU - Yovine, A AU - Yovine A AD - Oncology R&D, Late-Stage Development, AstraZeneca, Cambridge, UK. FAU - Kurland, J F AU - Kurland JF AD - Oncology R&D, Late-Stage Development, AstraZeneca, Gaithersburg. FAU - Morsli, N AU - Morsli N AD - Oncology R&D, Late-Stage Development, AstraZeneca, Cambridge, UK. FAU - Seiwert, T Y AU - Seiwert TY AD - Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, USA. Electronic address: tseiwert@jhmi.edu. CN - KESTREL Investigators LA - eng GR - 28724/CRUK_/Cancer Research UK/United Kingdom PT - Clinical Trial, Phase III PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20221216 PL - England TA - Ann Oncol JT - Annals of oncology : official journal of the European Society for Medical Oncology JID - 9007735 RN - 28X28X9OKV (durvalumab) RN - QEN1X95CIX (tremelimumab) RN - 0 (B7-H1 Antigen) SB - IM MH - Humans MH - Squamous Cell Carcinoma of Head and Neck/etiology MH - B7-H1 Antigen MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - Neoplasm Recurrence, Local MH - *Carcinoma, Squamous Cell MH - *Head and Neck Neoplasms/etiology OTO - NOTNLM OT - durvalumab OT - head and neck squamous cell carcinoma OT - immune checkpoint inhibition OT - phase III study OT - programmed death-ligand 1 OT - tremelimumab COIS- Disclosure AP has received research funding from Bristol Myers Squibb, DEMO, KURA Oncology, and Roche and consultant/advisory/honoraria fees from AstraZeneca, Bristol Myers Squibb, HPVtRNA, Merck Serono, MSD, Nanobiotics, and Pfizer companies. JF has served in a consulting or advisory role for Bristol Myers Squibb, Innate Pharma, Merck, Merck Sharp & Dohme, Rakuten, and Roche and has received non-financial support from Bristol Myers Squibb and Merck Sharp & Dohme. KH has received research funding from AstraZeneca, Boehringer Ingelheim, MSD, and Replimune, and consultant/advisory/honoraria fees from AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Codiak, Inzen, Merck Serono, Mersana Therapeutics, MSD, Pfizer, and Replimune. MG has received research funding from Agenus, Bristol Myers Squibb, Cullinan Labs, Genentech, Genocea Biosciences Inc., Kura, LaRoche, NRG, and University of Cincinnati. She has received consulting fees from Amgen Inc., Aspyrian Therapeutics, AstraZeneca Pharmaceuticals, Bayer Healthcare Pharmaceutics, Bicara Therapeutics, Bicara, BioNtech AG, Bristol Myers Squibb, Celgene Corp, Coherus Biosciences, Debiopharm, Eisai Medical Research Inc., EMD Serono, Inc., Genocea Biosciences Inc., Gilead Sciences Inc., Ipsen Biopharmaceuticals Inc., Istari Oncology Inc., iTeos Therapeutics, Kura Oncology, LLX Solutions, LLC, Merck & Co, Mirati Therapeutics, Nektar Therapeutics, NewLink Genetics Corp., OncLive Intellisphere, Roche Diagnostics GmbH, Roche, Seagen, Sensei Biotherapeutics Inc., Shattuck Labs Inc., and TRM Oncology. She received honoraria from OncLive and Roche. She has received support for attending meetings and/or travel from AACR, ASCO, and SITC. She reports an issued patent for NGVL4a-Sig/E7(detox)/HSP70 plasmid DNA for a clinical protocol entitled ‘An open-label phase one study of the safety with stage III or IV HPV16-positive head and neck squamous cell carcinoma’ and pending patents for oral HPV infection detection for oral cancer screening and diagnosis, and for HPV mRNA detection on oral cytology specimens for diagnosis and screening for oral cancer. She reports participation on a data safety monitoring board or advisory board for BioMimetix, Kura, NRG, Seagen, Sensei Biotherapeutics Inc., and SQZBiotech. She reports stock options with Sensei. MJA has received honoraria from AstraZeneca, Bristol Myers Squibb, MSD, ONO, and Roche and is a consultant or advisor for AstraZeneca, Bristol Myers Squibb, Takeda, MSD, Novartis, Roche, and Alpha pharmaceutical. ST reports grants from AstraZeneca, during the conduct of the study; grants and personal fees from Eisai, Novartis, Taiho, MSD, Chugai, Bayer, and Daiichi-Sankyo, outside the submitted work. JW has stock and other ownership interests in Achilles Therapeutics, Nektar Therapeutics, Vesselon, Nuvalent, En Fuego Therapeutics, and Lyell Immunopharma. He has a consulting or advisory role with AstraZeneca, EMD Serono, Genentech, G1 Therapeutics, Jounce Therapeutics, AbbVie, Nanobiotix, Azitra, Eli Lilly, Blueprint Medicines, Pfizer, Saatchi Wellness, Jazz Pharmaceuticals, Boehringer Ingelheim, Regeneron, Genmab, SDP Oncology, and BeiGene. He has received research funding from Mirati Therapeutics, Sumitomo Dainippon Pharma Oncology, Boehringer Ingelheim, and PDS Biotechnology. His institution has received research funding from Amgen, G1 Therapeutics, Immunicum, Inspirna, and Loxo/Lilly. He has had travel, accommodations, or expenses paid by Mirati Therapeutics. JPM is an advisory board member or speaker with honoraria (institution managed) for: Pfizer, Roche, AstraZeneca, Bayer, Innate, Merck Serono, Boehringer Ingelheim, Bristol Myers Squibb, Novartis, Janssen, Incyte, Cue Biopharma, ALX Oncology, iTEOS, eTheRNA, and Nektar Therapeutics. He has accepted travel expenses from: Amgen, Bristol Myers Squibb, Pfizer, and MSD. He is on the data safety monitoring board with honoraria for Psioxus. His institutional conflict of interest (funding to institution for research support) includes all companies. He has an uncompensated advisory role with MSD. SB reports owning stock in Roche Holding AG and is an employee of Verana Health. SCT reports receiving grant or research support from AstraZeneca and Eisai and consultant fees from AstraZeneca. RH is an employee of Dana-Farber Cancer Institute and has a leadership role with NCCN. He is a consultant or advisor for Achilles Therapeutics, AstraZeneca, Bayer, BioNTech AG, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Coherus Biosciences, Eisai, EMD Serono, Genentech, Gilead Sciences, GSK, Immunomic Therapeutics, Loxo, Merck, MIRATI, Pfizer, and Vaccinex. His institution has received research funding from AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Genentech, Kura, Merck, and Pfizer. He has other relationships with ISA Pharmaceuticals and Nanobiotix. SK received honoraria from Merck Serono, MSD, Novartis, Bristol Myers Squibb, Amgen, Roche, Sanofi-Aventis, Servier, Incyte, and Lilly; research funding from Merck Serono, Lilly, Bristol Myers Squibb, and Roche. PSM received advisory/lecture honoraria from BMS, KLS Martin Group, and Roche. He has accepted travel expenses from: AstraZeneca, BMS, GSK, KLS Martin Group, MSD, and Roche. VB is a freelance contractor for, and shareholder in, AstraZeneca. PH, BE, SW, RFO, AY, JFK, and NM are or were employees and shareholders of AstraZeneca. SW and NM report published patent WO2021228988A1. TYS has received grants/research funding from AstraZeneca, Bristol Myers Squibb, CUE biopharma, Kura, Merck/MSD, Nanobiotix, Regeneron, and Roche/Genentech, as well as honoraria from Bayer, BioNTech/Syneos, Coherur Biosciences, Cue Biopharma, Innate, KURA, Merck/MSD, Nanobiotix, Sanofi, Vir Biotechnology. All other authors have declared no conflicts of interest. EDAT- 2022/12/20 06:00 MHDA- 2023/02/25 06:00 CRDT- 2022/12/19 19:26 PHST- 2022/08/12 00:00 [received] PHST- 2022/12/07 00:00 [revised] PHST- 2022/12/13 00:00 [accepted] PHST- 2022/12/20 06:00 [pubmed] PHST- 2023/02/25 06:00 [medline] PHST- 2022/12/19 19:26 [entrez] AID - S0923-7534(22)04778-0 [pii] AID - 10.1016/j.annonc.2022.12.008 [doi] PST - ppublish SO - Ann Oncol. 2023 Mar;34(3):262-274. doi: 10.1016/j.annonc.2022.12.008. Epub 2022 Dec 16. PMID- 35433009 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220507 IS - 2051-3380 (Print) IS - 2051-3380 (Electronic) IS - 2051-3380 (Linking) VI - 10 IP - 5 DP - 2022 May TI - A case of extreme carboxyhaemoglominemia due to vaping. PG - e0942 LID - 10.1002/rcr2.942 [doi] LID - e0942 AB - Acute carbon monoxide (CO) poisoning is known to cause neurological, metabolic and cardiorespiratory sequalae. However, data on chronic CO exposure are scant, particularly in the context of vaping, which recent literature suggests may be a greater source of CO than tobacco cigarette smoking. During a series of admissions at the time of vaping, our patient repeatedly presented with significant CO poisoning and developed pulmonary arterial hypertension with resultant high-output right heart failure. On each occasion, our patient's levels of carboxyhaemoglobin were both higher and took longer to resolve than 12 smokers who underwent arterial blood gas testing at two time points. Our observation may reveal an association between vaping, chronic carboxyhaemoglobinemia and the development of cardiorespiratory disease. Thus, further studies into the safety of vaping and chronic CO exposure are urged. CI - © 2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. FAU - Grech, Audrey K AU - Grech AK AD - Department of Respiratory Medicine Alfred Health Melbourne Victoria Australia. FAU - Keating, Dominic T AU - Keating DT AD - Department of Respiratory Medicine Alfred Health Melbourne Victoria Australia. AD - Department of Medicine Monash University Melbourne Victoria Australia. FAU - Garner, Daniel J AU - Garner DJ AD - Department of Respiratory Medicine Alfred Health Melbourne Victoria Australia. FAU - Naughton, Matthew T AU - Naughton MT AUID- ORCID: 0000-0003-2734-0841 AD - Department of Respiratory Medicine Alfred Health Melbourne Victoria Australia. AD - Department of Medicine Monash University Melbourne Victoria Australia. LA - eng PT - Case Reports PT - Journal Article DEP - 20220413 PL - United States TA - Respirol Case Rep JT - Respirology case reports JID - 101631052 PMC - PMC9008159 OTO - NOTNLM OT - carboxyhaemoglobin OT - e‐cigarette OT - heart failure OT - pulmonary hypertension OT - vaping COIS- None declared. EDAT- 2022/04/19 06:00 MHDA- 2022/04/19 06:01 PMCR- 2022/04/13 CRDT- 2022/04/18 06:36 PHST- 2022/01/29 00:00 [received] PHST- 2022/02/22 00:00 [revised] PHST- 2022/03/15 00:00 [accepted] PHST- 2022/04/18 06:36 [entrez] PHST- 2022/04/19 06:00 [pubmed] PHST- 2022/04/19 06:01 [medline] PHST- 2022/04/13 00:00 [pmc-release] AID - RCR2942 [pii] AID - 10.1002/rcr2.942 [doi] PST - epublish SO - Respirol Case Rep. 2022 Apr 13;10(5):e0942. doi: 10.1002/rcr2.942. eCollection 2022 May. PMID- 21956611 OWN - NLM STAT- MEDLINE DCOM- 20150120 LR - 20191210 IS - 1866-3370 (Print) IS - 1866-3370 (Linking) VI - 9 DP - 2012 TI - Brain processes in discounting: consequences of adolescent methylphenidate exposure. PG - 113-43 LID - 10.1007/7854_2011_156 [doi] AB - Traits of inattention, impulsivity, and motor hyperactivity characterize children diagnosed with attention-deficit/hyperactivity disorder (ADHD), whose inhibitory control is reduced. In animal models, crucial developmental phases or experimental transgenic conditions account for peculiarities, such as sensation-seeking and risk-taking behaviors, and reproduce the beneficial effects of psychostimulants. An "impulsive" behavioral profile appears to emerge more extremely in rats when forebrain dopamine (DA) systems undergo remodeling, as in adolescence, or with experimental manipulation tapping onto the dopamine transporter (DAT). Ritalin(®) (methylphenidate, MPH), a DAT-blocking drug, is prescribed for ADHD therapy but is also widely abused by human adolescents. Administration of MPH during rats' adolescence causes a long-term modulation of their self-control, in terms of reduced intolerance to delay and diminished proneness for risk when reward is uncertain. Exactly the opposite profile emerges when exogenous alteration of DAT levels is achieved via lentiviral transfection. Both adolescent MPH exposure and DAT-targeting transfection lead to enduring hyperfunction of dorsal striatum and hypofunction of ventral striatum. Together with upregulation of prefronto-cortical phospho-creatine, striatal upregulation of selected genes (like serotonin 7 receptor gene) suggests that enhanced inhibitory control is generated by adolescent MPH exposure. Operant tasks, which assess the balance between motivational drives and inhibitory self-control, are thus useful for investigating reward-discounting processes and their modulation by DAT-targeting tools. In summary, due to the complexity of human studies, preclinical investigations of rodent models are necessary to understand better both the neurobiology of ADHD-like symptoms' etiology and the long-term therapeutic safety of adolescent MPH exposure. FAU - Adriani, Walter AU - Adriani W AD - Section of Behavioural Neuroscience, Department of Cell Biology & Neurosciences, Istituto Superiore di Sanitá, Viale Regina Elena 299, I-00161, Rome, Italy, walter.adriani@iss.it. FAU - Zoratto, Francesca AU - Zoratto F FAU - Laviola, Giovanni AU - Laviola G LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - Germany TA - Curr Top Behav Neurosci JT - Current topics in behavioral neurosciences JID - 101535383 RN - 0 (Central Nervous System Stimulants) RN - 0 (Membrane Transport Proteins) RN - 207ZZ9QZ49 (Methylphenidate) SB - IM MH - Adolescent MH - Animals MH - Attention Deficit Disorder with Hyperactivity/drug therapy/*pathology MH - Brain/drug effects/*physiopathology MH - Central Nervous System Stimulants/*therapeutic use MH - Disease Models, Animal MH - Humans MH - Inhibition, Psychological MH - Membrane Transport Proteins/metabolism MH - Methylphenidate/*therapeutic use MH - Up-Regulation/drug effects/genetics EDAT- 2011/10/01 06:00 MHDA- 2015/01/21 06:00 CRDT- 2011/09/30 06:00 PHST- 2011/09/30 06:00 [entrez] PHST- 2011/10/01 06:00 [pubmed] PHST- 2015/01/21 06:00 [medline] AID - 10.1007/7854_2011_156 [doi] PST - ppublish SO - Curr Top Behav Neurosci. 2012;9:113-43. doi: 10.1007/7854_2011_156. PMID- 21196446 OWN - NLM STAT- MEDLINE DCOM- 20120106 LR - 20211020 IS - 1522-9645 (Electronic) IS - 0195-668X (Print) IS - 0195-668X (Linking) VI - 32 IP - 8 DP - 2011 Apr TI - Stock volatility as a risk factor for coronary heart disease death. PG - 1006-11 LID - 10.1093/eurheartj/ehq495 [doi] AB - AIMS: The volatility of financial markets may cause substantial emotional and physical stress among investors. We hypothesize that this may have adverse effects on cardiovascular health. The Chinese stock markets were extremely volatile between 2006 and 2008. We, therefore, examined the relationship between daily change of the Shanghai Stock Exchange (SSE) Composite Index (referred as the Index) and coronary heart disease (CHD) deaths from 1 January 2006 to 31 December 2008 in Shanghai, the financial capital of China. METHODS AND RESULTS: Daily death and stock performance data were collected from the Shanghai Center for Disease Control and Prevention and SSE, respectively. Data were analysed with over-dispersed generalized linear Poisson models, controlling for long-term and seasonal trends of CHD mortality, day of the week, Index closing value, weather conditions, and air pollution levels. We observed a U-shaped relationship between the Index change and CHD deaths: both rising and falling of the Index were associated with more deaths and the fewest deaths coincided with little or no change of the index. We also examined the absolute daily change of the Index in relation to CHD deaths: in a 1-day lag model, each 100-point change of the Index corresponded to 5.17% (95% confidence interval: 1.71, 8.63%) increase in CHD deaths. Further analysis showed that the association was stronger for out-of-hospital CHD death than for in-hospital death. CONCLUSION: We found that CHD deaths fluctuated with daily stock changes in Shanghai, suggesting that stock volatility may adversely affect cardiovascular health. FAU - Ma, Wenjuan AU - Ma W AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China. FAU - Chen, Honglei AU - Chen H FAU - Jiang, Lili AU - Jiang L FAU - Song, Guixiang AU - Song G FAU - Kan, Haidong AU - Kan H LA - eng GR - Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural PT - Research Support, Non-U.S. Gov't DEP - 20101231 PL - England TA - Eur Heart J JT - European heart journal JID - 8006263 SB - IM MH - Adult MH - Aged MH - Cause of Death MH - China/epidemiology MH - Coronary Disease/economics/*mortality/psychology MH - Female MH - Humans MH - Investments/*statistics & numerical data MH - Male MH - Middle Aged MH - Risk Factors MH - Stress, Psychological/economics/*mortality MH - Urban Health PMC - PMC3076666 EDAT- 2011/01/05 06:00 MHDA- 2012/01/10 06:00 PMCR- 2012/04/01 CRDT- 2011/01/04 06:00 PHST- 2011/01/04 06:00 [entrez] PHST- 2011/01/05 06:00 [pubmed] PHST- 2012/01/10 06:00 [medline] PHST- 2012/04/01 00:00 [pmc-release] AID - ehq495 [pii] AID - 10.1093/eurheartj/ehq495 [doi] PST - ppublish SO - Eur Heart J. 2011 Apr;32(8):1006-11. doi: 10.1093/eurheartj/ehq495. Epub 2010 Dec 31. PMID- 33928390 OWN - NLM STAT- MEDLINE DCOM- 20211015 LR - 20211015 IS - 2576-9456 (Print) IS - 2475-7241 (Linking) VI - 6 IP - 3 DP - 2021 Apr 29 TI - Continuation of Over-the-Counter Biotin Supplements in the Inpatient Setting: An Unexpected Source of Laboratory Error. PG - 735-742 LID - 10.1093/jalm/jfaa167 [doi] AB - BACKGROUND: Over the past decade, use of high-dose biotin has increased significantly and can lead to erroneous results on some clinical immunoassays. In collaboration with pharmacists at our institution, we discovered that high biotin doses were being administered to inpatients as a continuation of patient-reported home biotin use. METHODS: This retrospective study evaluated high-dose biotin administration in 226 inpatient encounters from 2009 to 2019 and its potential impact on concurrent immunoassay testing. RESULTS: In 96% of cases, biotin was administered in the inpatient setting as a continuation of patient-reported home use. In total, 322 immunoassays capable of biotin interference were performed across 100 inpatient encounters with high-dose biotin administration. Troponin T and TSH were the most commonly performed immunoassays in this cohort. DISCUSSION: Even though less than 5% of all high-dose biotin orders at our institution are placed for inpatients, hospitalized patients are still at risk for mismanagement due to erroneous immunoassay results. Immunoassay testing susceptible to biotin interference was performed in approximately 45% of inpatient encounters with biotin administration. Laboratories utilizing biotin-susceptible, sensitive cardiac troponin assays should be particularly cautious. Pharmacokinetic data for biotin clearance is especially lacking for certain populations likely to be hospitalized, such as those with renal failure. Given that medical conditions requiring high-dose biotin therapy are extremely rare, we recommend restricting biotin dosing during inpatient encounters for all other patients. CI - © American Association for Clinical Chemistry 2020. All rights reserved. For permissions, please contact journals.permissions@oup.com. FAU - Merrill, Anna E AU - Merrill AE AD - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA. FAU - Malvik, Natalie M AU - Malvik NM AD - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA. AD - Division of Transfusion Medicine, Department of Medicine, UMass Memorial Medical Center, Worcester, MA. FAU - Ford, Diana C AU - Ford DC AD - Department of Pharmaceutical Care, University of Iowa Health Care, Iowa City, IA. FAU - Krasowski, Matthew D AU - Krasowski MD AD - Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA. LA - eng PT - Journal Article PL - England TA - J Appl Lab Med JT - The journal of applied laboratory medicine JID - 101693884 RN - 6SO6U10H04 (Biotin) SB - IM MH - *Biotin MH - Humans MH - Immunoassay MH - Inpatients MH - *Laboratories MH - Retrospective Studies OTO - NOTNLM OT - biotin OT - immunoassay OT - interference OT - patient safety EDAT- 2021/05/01 06:00 MHDA- 2021/10/16 06:00 CRDT- 2021/04/30 07:03 PHST- 2020/05/09 00:00 [received] PHST- 2020/08/24 00:00 [accepted] PHST- 2021/04/30 07:03 [entrez] PHST- 2021/05/01 06:00 [pubmed] PHST- 2021/10/16 06:00 [medline] AID - 6016490 [pii] AID - 10.1093/jalm/jfaa167 [doi] PST - ppublish SO - J Appl Lab Med. 2021 Apr 29;6(3):735-742. doi: 10.1093/jalm/jfaa167. PMID- 33540584 OWN - NLM STAT- MEDLINE DCOM- 20210325 LR - 20210325 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 18 IP - 3 DP - 2021 Feb 2 TI - Considerations in Planning Physical Activity for Older Adults in Hot Climates: A Narrative Review. LID - 10.3390/ijerph18031331 [doi] LID - 1331 AB - Regular physical activity has multiple health benefits for both the prevention and management of disease, including for older adults. However, additional precautions are needed with ageing given physiological changes and the increasing prevalence of comorbidities. Hot ambient temperatures increase the risks of exercise at any age, but are particularly important given thermoregulatory changes in older people. This narrative review informs planning of physical activity programs for older people living in rural areas with very hot climates for a period of the year. A multi-database search of peer-reviewed literature was undertaken with attention to its relevance to Australia, starting with definitions and standard advice in relation to physical activity programming and the incremental limitations imposed by age, rurality, and extreme heat. The enablers of and barriers to increasing physical activities in older adults and how they can be modified for those living in extreme hot climates is described. We describe multiple considerations in program design to improve safety, adherence and sustaining physical activity, including supervision, simple instructions, provision of reminders, social support, encouraging self-efficacy. Group-based activities may be preferred by some and can accommodate special populations, cultural considerations. Risk management is an important consideration and recommendations are provided to assist program planning. FAU - See, Lydia AU - See L AD - Western Australian Centre for Rural Health, School of Population and Global Health, University of Western Australia, Crawley 6009, Australia. AD - Oral Health Centre of Western Australia, School of Dentistry, University of Western Australia, Nedlands 6009, Australia. FAU - Rasiah, Rohan L AU - Rasiah RL AUID- ORCID: 0000-0003-3798-822X AD - Western Australian Centre for Rural Health, School of Population and Global Health, University of Western Australia, Crawley 6009, Australia. FAU - Laing, Rachael AU - Laing R AD - Western Australian Centre for Rural Health, School of Population and Global Health, University of Western Australia, Crawley 6009, Australia. FAU - Thompson, Sandra C AU - Thompson SC AUID- ORCID: 0000-0003-0327-7155 AD - Western Australian Centre for Rural Health, School of Population and Global Health, University of Western Australia, Crawley 6009, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20210202 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Aged MH - Aged, 80 and over MH - Australia MH - *Body Temperature Regulation MH - Climate MH - *Exercise MH - Humans MH - Social Support PMC - PMC7908220 OTO - NOTNLM OT - ageing OT - ambient environment OT - elderly OT - exercise OT - fitness intervention OT - heat OT - temperature OT - thermoregulation COIS- The authors declare no conflict of interest. EDAT- 2021/02/06 06:00 MHDA- 2021/03/26 06:00 PMCR- 2021/02/01 CRDT- 2021/02/05 01:00 PHST- 2021/01/18 00:00 [received] PHST- 2021/01/26 00:00 [accepted] PHST- 2021/02/05 01:00 [entrez] PHST- 2021/02/06 06:00 [pubmed] PHST- 2021/03/26 06:00 [medline] PHST- 2021/02/01 00:00 [pmc-release] AID - ijerph18031331 [pii] AID - ijerph-18-01331 [pii] AID - 10.3390/ijerph18031331 [doi] PST - epublish SO - Int J Environ Res Public Health. 2021 Feb 2;18(3):1331. doi: 10.3390/ijerph18031331. PMID- 31362512 OWN - NLM STAT- MEDLINE DCOM- 20200403 LR - 20200403 IS - 1445-6354 (Electronic) IS - 1445-6354 (Linking) VI - 19 IP - 3 DP - 2019 Jul TI - 'We have to drive everywhere': rural nurses and their precepted students. PG - 5347 LID - 10.22605/RRH5347 [doi] AB - INTRODUCTION: Travel safety culture is a vital aspect of nursing in rural western Canada, where long distances and severe weather are commonplace. However, this culture is poorly understood owing to the absence of official policy, and the tendency of rural nurses to take travel risks and burdens in stride, rather than advocating for change. Travel risks and burdens include extreme weather events such as tornadoes and blizzards; unmarked routes and hazards; distance, time and expense; and driver fatigue. In such rural settings, the safety and health of visitors, novices and students are of particular concern. The researchers sought to elicit the tacit knowledge of rural registered nurses, and their students undertaking rural nursing preceptorships, pertaining to rural travel issues and best practices for safety and wellbeing. METHODS: Through purposive and snowball sampling, the researchers recruited seven senior nursing students and five nurse preceptors. Seven rural acute and community care sites, between 42 km and 416 km distant from the students' primary place of study, were covered by the study. Photovoice, a participant action modality, was employed to collect photographic and qualitative interview data from participants over 10 weeks, between February and April 2016. The data were analyzed thematically, in collaboration with participants, who in turn validated the results. A digital storytelling initiative was attempted, to further involve participants in dissemination of findings, but only one participant took part in this phase of the project. RESULTS: The central finding of the study was that nursing students learn to accept and manage limitations - and to recognize and capitalize on opportunities - when undertaking rural preceptorships. With regard to road safety, the students were found to be particularly vulnerable to long distances, hazardous conditions, fuel and cellular data expenses, and fatigue. These issues were compounded by the students' reluctance to speak up, or to miss shifts, when they felt unsafe or unwell. Their preceptors role modeled autonomy and community ethos as the foundations of a frontline, extemporaneous road safety culture. This entailed personal safety measures borne from rural experience and background, familiarity with the countryside, and community connectedness with other healthcare sites in place of any official public alert system. The preceptors furthermore benefited from strong union protection for occupational health and safety concerns, but students being taught in rural settings had no such advantage. CONCLUSIONS: Nursing students should have the same occupational health and safety protections as their rural preceptors, especially the right to refuse travel, without penalty, in unsafe circumstances. Better travel subsidies and road safety measures during rural preceptorship may help increase the likelihood of students considering a rural career path. Furthermore, the frontline, community-based road safety experience of rural nurses is an untapped source of information for educators and policymakers. Such information will become more and more vital as a diminishing number of rural nurses are called upon to care for an aging client base. FAU - Yonge, Olive AU - Yonge O AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada olive.yonge@ualberta.ca. FAU - Jackman, Deirdre AU - Jackman D AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada deirdre.jackman@ualberta.ca. FAU - Luhanga, Florence AU - Luhanga F AD - Faculty of Nursing, Research and Innovation Centre, Room 508, University of Regina, 3737 Wascana Parkway, Regina, Saskatchewan, S4S 0A2, Canada florence.luhanga@uregina.ca. FAU - Myrick, Florence AU - Myrick F AD - Faculty of Nursing, University of Alberta, Level 3, Edmonton Clinic Health Academy, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada amyrick@ualberta.ca. FAU - Oosterbroek, Tracy AU - Oosterbroek T AD - Faculty of Health Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4, Canada tracy.oosterbroek@uleth.ca. FAU - Foley, Vicki AU - Foley V AD - Association of Registered Nurses of Prince Edward Island, Unit 6 - 161 Maypoint Rd., Charlottetown, Prince Edward Island, C1E 1X6, Canada vfoley@upei.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190731 PL - Australia TA - Rural Remote Health JT - Rural and remote health JID - 101174860 SB - IM MH - Automobile Driving/psychology MH - Canada MH - Geographic Information Systems MH - Humans MH - Interviews as Topic MH - Occupational Health MH - *Preceptorship MH - *Rural Health Services MH - Rural Population MH - *Students, Nursing/psychology MH - Travel OTO - NOTNLM OT - Photovoice OT - occupational health and safety OT - participant action research OT - preceptorship OT - roads OT - rural nursing OT - weather OT - Canada EDAT- 2019/08/01 06:00 MHDA- 2020/04/04 06:00 CRDT- 2019/08/01 06:00 PHST- 2019/08/01 06:00 [entrez] PHST- 2019/08/01 06:00 [pubmed] PHST- 2020/04/04 06:00 [medline] AID - 5347 [pii] AID - 10.22605/RRH5347 [doi] PST - ppublish SO - Rural Remote Health. 2019 Jul;19(3):5347. doi: 10.22605/RRH5347. Epub 2019 Jul 31. PMID- 39654164 OWN - NLM STAT- MEDLINE DCOM- 20241210 LR - 20241212 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 103 IP - 49 DP - 2024 Dec 6 TI - Hypertrophic pachymeningitis with cranial nerve palsy as the initial symptom: A case report. PG - e40903 LID - 10.1097/MD.0000000000040903 [doi] LID - e40903 AB - RATIONALE: Hypertrophic pachymeningitis (HP) is a rare and complex condition marked by inflammation and thickening of the dura mater. It can occur either on its own or as a result of various underlying medical issues. This type of granulomatous meningitis is extremely rare and poorly understood, making diagnosis and treatment particularly challenging. Patients with HP may experience severe headaches and cranial nerve defects, but in some cases, the condition can occur without any symptoms, making it undetected. We detail the case of patient who was diagnosed with HP after presenting with abducens nerve palsy, a condition that significantly affected her vision and quality of life. Remarkably, she showed substantial recovery following a course of methylprednisolone pulse therapy, coupled with careful radiographic diagnosis and follow-up assessments. The decision to report this case stems from its rarity and the diverse clinical manifestations associated with this condition, which can vary widely among patients. PATIENT CONCERNS: A 26-year-old Asian female, sought medical attention at The First Affiliated Hospital of Zhejiang Chinese Medical University, where she reported experiencing diplopia, a troubling symptom indicative of abducens nerve palsy. DIAGNOSIS: To establish a definitive diagnosis, second-generation sequencing biological detection was employed to rule out any infectious causes, while radiographic imaging provided confirmation of HP. INTERVENTIONS: In terms of intervention, the patient was promptly initiated on a regimen of methylprednisolone pulse therapy, followed by a carefully monitored oral sequential reduction of the medication. Throughout her treatment, she underwent regular liver function tests to ensure her safety, and liver protective drugs were also administered as a precautionary measure. OUTCOMES: As of now, the patient has successfully completed her treatment and is reported to be doing well, marking a positive outcome in her recovery journey. LESSONS: This case underscores the critical importance of imaging examinations in the clinical diagnosis of patients presenting with diplopia, as they play a vital role in both diagnosing and differentiating between various diseases. Furthermore, it is essential to rule out any infection-related factors in patients diagnosed with HP before commencing treatment with glucocorticoids, ensuring a comprehensive approach to patient care. CI - Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Xin AU - Zhang X AUID- ORCID: 0000-0001-5008-0879 AD - Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. LA - eng GR - 2023ZL388/the Project of Zhejiang Provincial TCM Science and Technology/ GR - 2022GJYY037/the Research Project of Zhejiang Chinese Medical University/ PT - Case Reports PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - X4W7ZR7023 (Methylprednisolone) RN - 0 (Glucocorticoids) SB - IM MH - Humans MH - Female MH - *Meningitis/diagnosis/complications MH - Adult MH - *Abducens Nerve Diseases/etiology/diagnosis MH - *Methylprednisolone/therapeutic use/administration & dosage MH - Hypertrophy MH - Glucocorticoids/therapeutic use/administration & dosage MH - Magnetic Resonance Imaging PMC - PMC11631007 COIS- The authors have no conflicts of interest to disclose. EDAT- 2024/12/10 06:23 MHDA- 2024/12/10 06:24 PMCR- 2024/12/06 CRDT- 2024/12/10 01:01 PHST- 2024/12/10 06:24 [medline] PHST- 2024/12/10 06:23 [pubmed] PHST- 2024/12/10 01:01 [entrez] PHST- 2024/12/06 00:00 [pmc-release] AID - 00005792-202412060-00007 [pii] AID - MD-D-24-07696 [pii] AID - 10.1097/MD.0000000000040903 [doi] PST - ppublish SO - Medicine (Baltimore). 2024 Dec 6;103(49):e40903. doi: 10.1097/MD.0000000000040903. PMID- 39866544 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20250130 IS - 2042-0986 (Print) IS - 2042-0994 (Electronic) IS - 2042-0986 (Linking) VI - 16 DP - 2025 TI - Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report. PG - 20420986241312484 LID - 10.1177/20420986241312484 [doi] LID - 20420986241312484 AB - The overlap of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome (SJS) caused by antituberculosis drugs represents an extremely rare event. This situation can manifest between 2 and 8 weeks after the first exposure to the medication. The overlap of these conditions can lead to atypical clinical manifestations, thus complicating the early diagnosis and the implementation of early treatment. This report describes the case of a patient who developed the DRESS/SJS overlap 35 days after starting antituberculosis treatment. The patient experienced severe skin and systemic involvement, a situation that required her admission and monitoring in the intensive care unit. From our experience with this case, we conclude the importance of an accurate and timely diagnosis using validated scoring systems such as RegiSCAR to confirm the clinical diagnosis of DRESS/SJS and ALDEN to assess the likelihood of drug causality. Timely intervention with corticosteroids plays a key role in moderating the exaggerated immune response, helping to alleviate dermatological symptoms and prevent long-term organ damage. In addition, the availability of safe therapeutic alternatives for tuberculosis treatment allows for more effective and safer management in these patients. CI - © The Author(s), 2025. FAU - Morán-Mariños, Cristian AU - Morán-Mariños C AUID- ORCID: 0000-0002-1353-0540 AD - Unidad de Investigación en Bibliometría, Vicerrectorado de investigación, Unidad San Ignacio de Loyola, Av. La Fontana 550, Lima, 15024, Perú. AD - Unidad Especializada en Tuberculosis, Servicio de Neumologia, Hospital Nacional Dos de Mayo, Lima, Perú. FAU - Llanos-Tejada, Felix AU - Llanos-Tejada F AD - Unidad Especializada en Tuberculosis, Servicio de Neumologia, Hospital Nacional Dos de Mayo, Lima, Perú. FAU - Huamani-Llantoy, Rebeca AU - Huamani-Llantoy R AD - Servicio de Dermatología, Hospital Nacional Dos de Mayo, Lima, Perú. FAU - Bernal-Turpo, Capriny AU - Bernal-Turpo C AD - Unidad Especializada en Tuberculosis, Servicio de Neumologia, Hospital Nacional Dos de Mayo, Lima, Perú. FAU - López-Pilco, Kimberly AU - López-Pilco K AD - Unidad de Cuidados Intensivos, Hospital Nacional Dos de Mayo, Lima, Perú. FAU - Ventura-Leon, Alex AU - Ventura-Leon A AD - Departamento de Patología, Hospital Nacional Cayetano Heredia, Lima, Perú. FAU - Casanova-Mendoza, Renato AU - Casanova-Mendoza R AD - Unidad Especializada en Tuberculosis, Servicio de Neumologia, Hospital Nacional Dos de Mayo, Lima, Perú. LA - eng PT - Case Reports PT - Journal Article DEP - 20250124 PL - England TA - Ther Adv Drug Saf JT - Therapeutic advances in drug safety JID - 101549074 PMC - PMC11760121 OAB - Antituberculosis drugs can cause two serious skin reactions Why are we talking about this? When a person starts tuberculosis treatment with certain medications, there is a small chance they could develop two serious skin conditions at the same time: DRESS syndrome and Stevens-Johnson syndrome (SJS). Although extremely rare, these conditions can be very dangerous and challenging to manage, especially if not identified early. What happened in this case? In this report, we present the case of a patient who developed both conditions about a month after starting tuberculosis treatment. These problems severely affected the patient’s skin and also caused damage to other organs, requiring intensive care in the hospital. What did we learn from this case? This case highlights the importance of making an early and accurate diagnosis. Tools like the RegiSCAR and ALDEN scoring systems are very helpful for quickly identifying these reactions. We also learned that starting the appropriate treatment as soon as possible is essential to prevent complications. In cases like this, it is crucial to consider safer treatment options for tuberculosis when severe reactions occur. Why is this important? This case reminds us that, while these reactions are very rare, it is essential for doctors to be prepared to identify and manage them appropriately. It also emphasizes the need to adapt tuberculosis treatment to ensure patient safety without compromising its effectiveness. OABL- eng OTO - NOTNLM OT - Stevens-Johnson syndrome OT - antitubercular agents OT - drug hypersensitivity syndrome OT - hypersensitivity OT - tuberculosis EDAT- 2025/01/27 06:20 MHDA- 2025/01/27 06:21 PMCR- 2025/01/24 CRDT- 2025/01/27 05:40 PHST- 2024/04/27 00:00 [received] PHST- 2024/12/18 00:00 [accepted] PHST- 2025/01/27 06:21 [medline] PHST- 2025/01/27 06:20 [pubmed] PHST- 2025/01/27 05:40 [entrez] PHST- 2025/01/24 00:00 [pmc-release] AID - 10.1177_20420986241312484 [pii] AID - 10.1177/20420986241312484 [doi] PST - epublish SO - Ther Adv Drug Saf. 2025 Jan 24;16:20420986241312484. doi: 10.1177/20420986241312484. eCollection 2025. PMID- 36625802 OWN - NLM STAT- MEDLINE DCOM- 20230112 LR - 20230112 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 52 IP - 1 DP - 2023 Jan TI - COVID-19 Vaccines in Children. PG - e4-e7 LID - 10.3928/19382359-20221114-02 [doi] AB - The coronavirus disease 2019 (COVID-19) pandemic has transformed the world. It has highlighted health inequities, the lack of social safety nets, and the limitations of health care systems. But it has also paved the way for medical ingenuity and technological advances in the face of these extreme challenges. One such medical marvel is the COVID-19 vaccine. The ability to rapidly create and mass produce a safe and effective vaccine for both adults and children has been essential to minimizing the harm of COVID-19, reducing the burden on hospitals and ushering in some semblance of return to pre-COVID times. Although vaccine hesitancy and long-standing health inequities have limited the number of children who have received the COVID-19 vaccine, the recommended vaccines remain a vital tool in ensuring healthy growth and development of children. [Pediatr Ann. 2023;52(1):e4-e7.]. FAU - DeZure, Chandani AU - DeZure C LA - eng PT - Journal Article DEP - 20230101 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 RN - 0 (COVID-19 Vaccines) RN - 0 (Vaccines) SB - IM MH - Adult MH - Child MH - Humans MH - COVID-19 Vaccines MH - *COVID-19/epidemiology/prevention & control MH - Health Status MH - Hospitals MH - Pandemics MH - *Vaccines MH - Vaccination EDAT- 2023/01/11 06:00 MHDA- 2023/01/13 06:00 CRDT- 2023/01/10 11:02 PHST- 2023/01/10 11:02 [entrez] PHST- 2023/01/11 06:00 [pubmed] PHST- 2023/01/13 06:00 [medline] AID - 10.3928/19382359-20221114-02 [doi] PST - ppublish SO - Pediatr Ann. 2023 Jan;52(1):e4-e7. doi: 10.3928/19382359-20221114-02. Epub 2023 Jan 1. PMID- 36079076 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220913 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 11 IP - 17 DP - 2022 Aug 31 TI - Physical Agent-Based Treatments for Overactive Bladder: A Review. LID - 10.3390/jcm11175150 [doi] LID - 5150 AB - Almost one-fifth of the people in the world experience a decrease in quality of life due to overactive bladder (OAB) syndrome. The main bothersome symptoms are urgency accompanied by urinary frequency and nocturia. This chronic, disabling condition is first managed by reducing fluid intake and pelvic floor muscle training, supplemented with antimuscarinic drugs, if necessary. However, refractory cases often still occur. In more severe cases, invasive surgical interventions can be considered; yet, the success rate is still inconsistent, and there is a high complication rate. This condition is frustrating for patients and challenging for the medical staff involved. Although its pathophysiology has not been fully elucidated, peripheral autonomic somatic and sensory afferent receptors are considered to be involved in this condition. Hence, currently, physical agent-based treatments such as neuromodulation have taken a significant place in the third-line therapy of OAB. The efficacy and safety profiles of electrical and magnetic stimulation continue to evolve. Physical-based agents provide an appealing option owing to their effectiveness and minimal side effects. In addition, more physical therapies using light and shock energy are currently being investigated. Thus, a comprehensive understanding of these modalities is an extremely important aspect to provide the most suitable modalities for patients. FAU - Khasanah, Nurida AU - Khasanah N AUID- ORCID: 0000-0002-9710-0918 AD - Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. AD - Department of Obstetrics and Gynecology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada-Dr Sardjito General Hospital, Yogyakarta 55281, Indonesia. FAU - Chin, Hung-Yen AU - Chin HY AD - Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei 11031, Taiwan. AD - Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. FAU - Peng, Chih-Wei AU - Peng CW AUID- ORCID: 0000-0001-9744-4094 AD - Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. AD - School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. AD - International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. AD - School of Gerontology and Long-Term Care, College of Nursing, Taipei Medical University, Taipei 11031, Taiwan. AD - Research Center of Biomedical Device, Taipei Medical University, Taipei 11031, Taiwan. LA - eng GR - USTP-NTUT-TMU-111-03/University System of Taipei Joint Research Program of Taiwan/ GR - 110-2314-B-038-001, 110-2811-E-038-500-MY3, 110-2314-B-305-001, 109-2314-B-305-001, 109-2221-E-305-001-MY2, 109-2221-E-038-005-MY3, and 109-2314-B-038-132/Ministry of Science and Technology/ PT - Journal Article PT - Review DEP - 20220831 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC9456779 OTO - NOTNLM OT - electrical stimulation OT - laser OT - low-intensity shock energy OT - magnetic stimulation OT - neuromodulation OT - overactive bladder OT - physical-based agent COIS- All authors declare no conflict of interest. EDAT- 2022/09/10 06:00 MHDA- 2022/09/10 06:01 PMCR- 2022/08/31 CRDT- 2022/09/09 01:20 PHST- 2022/08/15 00:00 [received] PHST- 2022/08/29 00:00 [revised] PHST- 2022/08/29 00:00 [accepted] PHST- 2022/09/09 01:20 [entrez] PHST- 2022/09/10 06:00 [pubmed] PHST- 2022/09/10 06:01 [medline] PHST- 2022/08/31 00:00 [pmc-release] AID - jcm11175150 [pii] AID - jcm-11-05150 [pii] AID - 10.3390/jcm11175150 [doi] PST - epublish SO - J Clin Med. 2022 Aug 31;11(17):5150. doi: 10.3390/jcm11175150. PMID- 34060410 OWN - NLM STAT- MEDLINE DCOM- 20220112 LR - 20220112 IS - 1745-7319 (Electronic) IS - 1745-7300 (Linking) VI - 28 IP - 4 DP - 2021 Dec TI - Injury severity prediction of traffic crashes with ensemble machine learning techniques: a comparative study. PG - 408-427 LID - 10.1080/17457300.2021.1928233 [doi] AB - A better understanding of injury severity risk factors is fundamental to improving crash prediction and effective implementation of appropriate mitigation strategies. Traditional statistical models widely used in this regard have predefined correlation and intrinsic assumptions, which, if flouted, may yield biased predictions. The present study investigates the possibility of using the eXtreme Gradient Boosting (XGBoost) model compared with few traditional machine learning algorithms (logistic regression, random forest, and decision tree) for crash injury severity analysis. The data used in this study was obtained from the traffic safety department, ministry of transport (MOT) at Riyadh, KSA, and contains 13,546 motor vehicle collisions along 15 rural highways reported between January 2017 to December 2019. Empirical results obtained using k-fold (k = 10) for various performance metrics showed that the XGBoost technique outperformed other models in terms of the collective predictive performance as well as injury severity individual class accuracies. XGBoost feature importance analysis indicated that collision type, weather status, road surface conditions, on-site damage type, lighting conditions, and vehicle type are the few sensitive variables in predicting the crash injury severity outcome. Finally, a comparative analysis of XGBoost based on different performance statistics showed that our model outperformed most previous studies. FAU - Jamal, Arshad AU - Jamal A AD - Department of Civil and Environmental Engineering, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia. FAU - Zahid, Muhammad AU - Zahid M AD - College of Metropolitan Transportation, Beijing University of Technology, Beijing, China. FAU - Tauhidur Rahman, Muhammad AU - Tauhidur Rahman M AD - Department of City and Regional Planning, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia. FAU - Al-Ahmadi, Hassan M AU - Al-Ahmadi HM AD - Department of Civil and Environmental Engineering, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia. FAU - Almoshaogeh, Meshal AU - Almoshaogeh M AD - Department of Civil Engineering, College of Engineering, Qassim University, Buraydah, Qassim, Saudi Arabia. FAU - Farooq, Danish AU - Farooq D AD - Department of Transport Technology and Economics, Budapest University of Technology and Economics, Budapest, Hungary. AD - Department of Civil Engineering, University of Engineering and Technology Peshawar (Bannu Campus), Peshawar, Pakistan. FAU - Ahmad, Mahmood AU - Ahmad M AD - Department of Civil Engineering, University of Engineering and Technology Peshawar (Bannu Campus), Peshawar, Pakistan. LA - eng PT - Journal Article DEP - 20210601 PL - England TA - Int J Inj Contr Saf Promot JT - International journal of injury control and safety promotion JID - 101247254 SB - IM MH - *Accidents, Traffic MH - Algorithms MH - Humans MH - Logistic Models MH - *Machine Learning MH - Models, Statistical OTO - NOTNLM OT - Traffic crashes OT - XGBoost OT - crash injury severity prediction OT - feature sensitivity analysis OT - machine learning EDAT- 2021/06/02 06:00 MHDA- 2022/01/13 06:00 CRDT- 2021/06/01 08:42 PHST- 2021/06/02 06:00 [pubmed] PHST- 2022/01/13 06:00 [medline] PHST- 2021/06/01 08:42 [entrez] AID - 10.1080/17457300.2021.1928233 [doi] PST - ppublish SO - Int J Inj Contr Saf Promot. 2021 Dec;28(4):408-427. doi: 10.1080/17457300.2021.1928233. Epub 2021 Jun 1. PMID- 27878313 OWN - NLM STAT- MEDLINE DCOM- 20170828 LR - 20220330 IS - 1432-0428 (Electronic) IS - 0012-186X (Print) IS - 0012-186X (Linking) VI - 60 IP - 2 DP - 2017 Feb TI - Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition. PG - 215-225 LID - 10.1007/s00125-016-4157-3 [doi] AB - Healthy kidneys filter ∼160 g/day of glucose (∼30% of daily energy intake) under euglycaemic conditions. To prevent valuable energy from being lost in the urine, the proximal tubule avidly reabsorbs filtered glucose up to a limit of ∼450 g/day. When blood glucose levels increase to the point that the filtered load exceeds this limit, the surplus is excreted in the urine. Thus, the kidney provides a safety valve that can prevent extreme hyperglycaemia as long as glomerular filtration is maintained. Most of the capacity for renal glucose reabsorption is provided by sodium glucose cotransporter (SGLT) 2 in the early proximal tubule. In the absence or with inhibition of SGLT2, the renal reabsorptive capacity for glucose declines to ∼80 g/day (the residual capacity of SGLT1), i.e. the safety valve opens at a lower threshold, which makes it relevant to glucose homeostasis from day-to-day. Several SGLT2 inhibitors are now approved glucose lowering agents for individuals with type 2 diabetes and preserved kidney function. By inducing glucosuria, these drugs improve glycaemic control in all stages of type 2 diabetes, while their risk of causing hypoglycaemia is low because they naturally stop working when the filtered glucose load falls below ∼80 g/day and they do not otherwise interfere with metabolic counterregulation. Through glucosuria, SGLT2 inhibitors reduce body weight and body fat, and shift substrate utilisation from carbohydrates to lipids and, possibly, ketone bodies. Because SGLT2 reabsorbs sodium along with glucose, SGLT2 blockers are natriuretic and antihypertensive. Also, because they work in the proximal tubule, SGLT2 inhibitors increase delivery of fluid and electrolytes to the macula densa, thereby activating tubuloglomerular feedback and increasing tubular back pressure. This mitigates glomerular hyperfiltration, reduces the kidney's demand for oxygen and lessens albuminuria. For reasons that are less well understood, SGLT2 inhibitors are also uricosuric. These pleiotropic effects of SGLT2 inhibitors are likely to have contributed to the results of the EMPA-REG OUTCOME trial in which the SGLT2 inhibitor, empagliflozin, slowed the progression of chronic kidney disease and reduced major adverse cardiovascular events in high-risk individuals with type 2 diabetes. This review discusses the role of SGLT2 in the physiology and pathophysiology of renal glucose reabsorption and outlines the unexpected logic of inhibiting SGLT2 in the diabetic kidney. FAU - Vallon, Volker AU - Vallon V AD - Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. vvallon@ucsd.edu. AD - Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA. vvallon@ucsd.edu. AD - Divison of Nephrology, VA San Diego Healthcare System, 3350 La Jolla Village Drive (9151), San Diego, CA, 92161, USA. vvallon@ucsd.edu. FAU - Thomson, Scott C AU - Thomson SC AD - Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA, 92093, USA. AD - Divison of Nephrology, VA San Diego Healthcare System, 3350 La Jolla Village Drive (9151), San Diego, CA, 92161, USA. LA - eng GR - P30 DK079337/DK/NIDDK NIH HHS/United States GR - R01 DK056248/DK/NIDDK NIH HHS/United States GR - R01 DK106102/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Review DEP - 20161122 PL - Germany TA - Diabetologia JT - Diabetologia JID - 0006777 RN - 0 (Sodium-Glucose Transporter 2) RN - 0 (Sodium-Glucose Transporter 2 Inhibitors) RN - CU9S17279X (Phlorhizin) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Diabetes Mellitus, Type 2/drug therapy/metabolism MH - Glucose/*metabolism MH - Humans MH - Hyperglycemia/drug therapy/*metabolism MH - Insulin Resistance/physiology MH - Kidney/*metabolism MH - Phlorhizin/therapeutic use MH - Sodium-Glucose Transporter 2/*metabolism MH - *Sodium-Glucose Transporter 2 Inhibitors PMC - PMC5884445 MID - NIHMS954782 OTO - NOTNLM OT - Body weight OT - Cardiovascular outcome OT - Chronic kidney disease OT - Diabetic nephropathy OT - EMPA-REG OUTCOME trial OT - Glomerular hyperfiltration OT - Gluconeogenesis OT - Hypertension OT - Renal glucose reabsorption OT - Review OT - Sodium glucose cotransport EDAT- 2016/11/24 06:00 MHDA- 2017/08/29 06:00 PMCR- 2018/04/04 CRDT- 2016/11/24 06:00 PHST- 2016/09/12 00:00 [received] PHST- 2016/10/17 00:00 [accepted] PHST- 2016/11/24 06:00 [pubmed] PHST- 2017/08/29 06:00 [medline] PHST- 2016/11/24 06:00 [entrez] PHST- 2018/04/04 00:00 [pmc-release] AID - 10.1007/s00125-016-4157-3 [pii] AID - 10.1007/s00125-016-4157-3 [doi] PST - ppublish SO - Diabetologia. 2017 Feb;60(2):215-225. doi: 10.1007/s00125-016-4157-3. Epub 2016 Nov 22. PMID- 19951309 OWN - NLM STAT- MEDLINE DCOM- 20101013 LR - 20220411 IS - 1423-0410 (Electronic) IS - 0042-9007 (Linking) VI - 98 IP - 4 DP - 2010 May TI - Transfusion-transmitted arboviruses. PG - 495-503 LID - 10.1111/j.1423-0410.2009.01286.x [doi] AB - There exists considerable risk for transfusion transmission of arboviruses due to short periods of asymptomatic viraemia in populations with variable and sometimes extremely high incidence of arboviral infections. Aside from West Nile virus, few arbovirus transfusion transmissions have been proven, mostly due to difficulties in ruling out vector-borne transmission in recipients with arbovirus disease. Nevertheless, arbovirus transfusion risk models and assessments of viraemia prevalence in blood donations indicate substantial transfusion transmission of dengue and Chikungunya viruses in epidemic areas. Many other arboviruses, several of which are importation risks in the Americas, Europe and Asia, also cause large outbreaks and threaten transfusion safety. Prevention largely depends on excluding donors from outbreak areas or implementation of highly sensitive nucleic acid amplification tests. Because of the increasing emergence of arboviral disease globally, it is prudent to prepare for both endemic and exotic arboviruses capable of producing large epidemics and subsequent transfusion transmission risk. FAU - Petersen, L R AU - Petersen LR AD - Division of Vector-borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA. lxp2@cdc.gov FAU - Busch, M P AU - Busch MP LA - eng PT - Journal Article PT - Review DEP - 20091125 PL - England TA - Vox Sang JT - Vox sanguinis JID - 0413606 SB - IM MH - Arbovirus Infections/blood/*transmission MH - Humans MH - Risk Factors MH - *Transfusion Reaction MH - Viremia/blood/*transmission RF - 61 EDAT- 2009/12/03 06:00 MHDA- 2010/10/14 06:00 CRDT- 2009/12/03 06:00 PHST- 2009/12/03 06:00 [entrez] PHST- 2009/12/03 06:00 [pubmed] PHST- 2010/10/14 06:00 [medline] AID - VOX1286 [pii] AID - 10.1111/j.1423-0410.2009.01286.x [doi] PST - ppublish SO - Vox Sang. 2010 May;98(4):495-503. doi: 10.1111/j.1423-0410.2009.01286.x. Epub 2009 Nov 25. PMID- 36109091 OWN - NLM STAT- MEDLINE DCOM- 20220919 LR - 20240915 IS - 1757-790X (Electronic) IS - 1757-790X (Linking) VI - 15 IP - 9 DP - 2022 Sep 15 TI - Pain management of pemphigus vulgaris. LID - 10.1136/bcr-2022-250803 [doi] LID - e250803 AB - Pemphigus is a rare autoimmune bullous disease which affects the mucous membranes and skin. Pemphigus vulgaris (PV) is the most prevalent type of pemphigus. PV presents with extremely painful, non-healing oral erosions. However, there are only a handful of reports addressing the pain management of PV. We would like to present a case of a painful PV, which was successfully managed. CI - © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Muniandy, Rajesh Kumar AU - Muniandy RK AUID- ORCID: 0000-0002-5554-2769 AD - Department of Anaesthesia and Intensive Care, University of Malaysia Sabah, Kota Kinabalu, Malaysia rajeshkumar@ums.edu.my. FAU - Nagalingam, Nagarajan AU - Nagalingam N AD - Anaesthesia and Intensive Care, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia. FAU - Liew, Sat Lin AU - Liew SL AD - Department of Anaesthesia and Intensive Care, University of Malaysia Sabah, Kota Kinabalu, Malaysia. FAU - Michelle Voo, Sook Yee AU - Michelle Voo SY AD - Department of Dermatology, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia. LA - eng PT - Case Reports PT - Journal Article DEP - 20220915 PL - England TA - BMJ Case Rep JT - BMJ case reports JID - 101526291 SB - IM MH - Humans MH - Mucous Membrane MH - Pain/etiology MH - Pain Management MH - *Pemphigus/complications/drug therapy MH - Skin PMC - PMC9478788 OTO - NOTNLM OT - Dermatological OT - Healthcare improvement and patient safety OT - Pain COIS- Competing interests: None declared. EDAT- 2022/09/16 06:00 MHDA- 2022/09/20 06:00 PMCR- 2024/09/14 CRDT- 2022/09/15 20:52 PHST- 2022/09/15 20:52 [entrez] PHST- 2022/09/16 06:00 [pubmed] PHST- 2022/09/20 06:00 [medline] PHST- 2024/09/14 00:00 [pmc-release] AID - 15/9/e250803 [pii] AID - bcr-2022-250803 [pii] AID - 10.1136/bcr-2022-250803 [doi] PST - epublish SO - BMJ Case Rep. 2022 Sep 15;15(9):e250803. doi: 10.1136/bcr-2022-250803. PMID- 33916354 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210502 IS - 1996-1944 (Print) IS - 1996-1944 (Electronic) IS - 1996-1944 (Linking) VI - 14 IP - 7 DP - 2021 Apr 5 TI - Influence of Silica-Aerogel on Mechanical Characteristics of Polyurethane-Based Composites: Thermal Conductivity and Strength. LID - 10.3390/ma14071790 [doi] LID - 1790 AB - Polyurethane foam (PUF) has generally been used in liquefied natural gas (LNG) carrier cargo containment systems (CCSs) owing to its excellent mechanical and thermal properties over a wide range of temperatures. An LNG CCS must be designed to withstand extreme environmental conditions. However, as the insulation material for LNGC CCSs, PUF has two major limitations: its strength and thermal conductivity. In the present study, PUFs were synthesized with various weight percentages of porous silica aerogel to reinforce the characteristics of PUF used in LNG carrier insulation systems. To evaluate the mechanical strength of the PUF-silica aerogel composites considering LNG loading/unloading environmental conditions, compressive tests were conducted at room temperature (20 °C) and a cryogenic temperature (-163 °C). In addition, the thermal insulation performance and cellular structure were identified to analyze the effects of silica aerogels on cell morphology. The cell morphology of PUF-silica aerogel composites was relatively homogeneous, and the cell shape remained closed at 1 wt.% in comparison to the other concentrations. As a result, the mechanical and thermal properties were significantly improved by the addition of 1 wt.% silica aerogel to the PUF. The mechanical properties were reduced by increasing the silica aerogel content to 3 wt.% and 5 wt.%, mainly because of the pores generated on the surface of the composites. FAU - Kim, Jeong-Hyeon AU - Kim JH AD - Hydrogen Ship Technology Center, Pusan National University, Busan 36241, Korea. FAU - Ahn, Jae-Hyeok AU - Ahn JH AD - Hyundai Heavy Industries Co., Ltd., Ulsan 44032, Korea. FAU - Kim, Jeong-Dae AU - Kim JD AD - Department of Naval Architecture and Ocean Engineering, Pusan National University, Busan 46241, Korea. FAU - Lee, Dong-Ha AU - Lee DH AD - Department of Naval Architecture and Ocean Engineering, Pusan National University, Busan 46241, Korea. FAU - Kim, Seul-Kee AU - Kim SK AD - Hydrogen Ship Technology Center, Pusan National University, Busan 36241, Korea. FAU - Lee, Jae-Myung AU - Lee JM AD - Hydrogen Ship Technology Center, Pusan National University, Busan 36241, Korea. AD - Department of Naval Architecture and Ocean Engineering, Pusan National University, Busan 46241, Korea. LA - eng GR - Development of the safety standards for marine hydrogen storage vessels and fuel supply systems/Ministry of Oceans and Fisheries of Korea/ GR - 20006644/Ministry of Trade, Industry & Energy of Korea/ PT - Journal Article DEP - 20210405 PL - Switzerland TA - Materials (Basel) JT - Materials (Basel, Switzerland) JID - 101555929 PMC - PMC8038616 OTO - NOTNLM OT - cryogenics OT - mechanical properties OT - polyurethane foam OT - silica aerogel OT - thermal conductivity COIS- The authors declare no conflict of interest. EDAT- 2021/05/01 06:00 MHDA- 2021/05/01 06:01 PMCR- 2021/04/05 CRDT- 2021/04/30 01:03 PHST- 2021/02/23 00:00 [received] PHST- 2021/03/30 00:00 [revised] PHST- 2021/04/02 00:00 [accepted] PHST- 2021/04/30 01:03 [entrez] PHST- 2021/05/01 06:00 [pubmed] PHST- 2021/05/01 06:01 [medline] PHST- 2021/04/05 00:00 [pmc-release] AID - ma14071790 [pii] AID - materials-14-01790 [pii] AID - 10.3390/ma14071790 [doi] PST - epublish SO - Materials (Basel). 2021 Apr 5;14(7):1790. doi: 10.3390/ma14071790. PMID- 33044643 OWN - NLM STAT- MEDLINE DCOM- 20220203 LR - 20220203 IS - 1432-1254 (Electronic) IS - 0020-7128 (Linking) VI - 66 IP - 2 DP - 2022 Feb TI - Characterizing observed surface wind speed in the Hudson Bay and Labrador regions of Canada from an aviation perspective. PG - 411-425 LID - 10.1007/s00484-020-02021-9 [doi] AB - Wind speed analysis is important for informing airport operation and safety. Many communities in the Hudson Bay and Labrador regions (Canada) are remote communities that rely heavily on aircraft for passenger and freight movement. Historical trends in average daily wind speed and maximum daily wind speed from 1971 to 2010 were examined to identify patterns of change and determine how these changes may influence aviation in six northern communities across Hudson Bay and Labrador in Canada. Significant increases in average wind speed and maximum wind speed were found for some of the months and seasons of the year for the Hudson Bay region, along with a significant decrease in those variables for the Labrador communities. Average wind speeds at multiple locations are approaching the threshold (18.5 km/h or 10 knots) when take-off and landing would be restricted to one direction. The results of this study agree with previous research that examined historical patterns for wind speed in these regions but calls into question climate change impact assessments that suggest wind speeds will continue to increase under future climatic conditions for this study area. Future research is needed to further analyse shifts in prevailing wind directions and changes in the frequency of extreme wind conditions, to better understand the potential impacts of projected climate change on this climatic variable and the implications these changes may have on applied sectors, such as aviation. CI - © 2020. ISB. FAU - Leung, Andrew C W AU - Leung ACW AUID- ORCID: 0000-0001-6681-7273 AD - Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. andrewc.leung@mail.utoronto.ca. FAU - Gough, William A AU - Gough WA AUID- ORCID: 0000-0003-0618-8967 AD - Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. FAU - Butler, Ken A AU - Butler KA AD - Department of Computer & Mathematical Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. FAU - Mohsin, Tanzina AU - Mohsin T AUID- ORCID: 0000-0001-7402-8899 AD - Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. FAU - Hewer, Micah J AU - Hewer MJ AUID- ORCID: 0000-0003-4524-8184 AD - Department of Physical & Environmental Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, Ontario, M1C 1A4, Canada. LA - eng PT - Journal Article DEP - 20201012 PL - United States TA - Int J Biometeorol JT - International journal of biometeorology JID - 0374716 SB - IM MH - *Aviation MH - Climate Change MH - Newfoundland and Labrador MH - Seasons MH - *Wind OTO - NOTNLM OT - Air transportation OT - Airports OT - Climate change OT - Northern Canada OT - Nunavik OT - Time series analysis EDAT- 2020/10/13 06:00 MHDA- 2022/02/04 06:00 CRDT- 2020/10/12 12:12 PHST- 2020/03/06 00:00 [received] PHST- 2020/09/07 00:00 [accepted] PHST- 2020/08/26 00:00 [revised] PHST- 2020/10/13 06:00 [pubmed] PHST- 2022/02/04 06:00 [medline] PHST- 2020/10/12 12:12 [entrez] AID - 10.1007/s00484-020-02021-9 [pii] AID - 10.1007/s00484-020-02021-9 [doi] PST - ppublish SO - Int J Biometeorol. 2022 Feb;66(2):411-425. doi: 10.1007/s00484-020-02021-9. Epub 2020 Oct 12. PMID- 30520621 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20191120 IS - 1944-8252 (Electronic) IS - 1944-8244 (Linking) VI - 11 IP - 1 DP - 2019 Jan 9 TI - Robustly Superhydrophobic Conductive Textile for Efficient Electromagnetic Interference Shielding. PG - 1680-1688 LID - 10.1021/acsami.8b18459 [doi] AB - Superhydrophobic electromagnetic interference (EMI) shielding textile (EMIST) is of great significance to the safety and long-term service of all-weather outdoor equipment. However, it is still challenging to achieve long-term durability and stability under external mechanical deformations or other harsh service conditions. Herein, by designing and implementing silver nanowire (AgNW) networks and a superhydrophobic coating onto a commercial textile, we demonstrate a highly robust superhydrophobic EMIST. The resultant EMIST shows a synergy of high water contact angle (160.8°), low sliding angle (2.9°), and superior EMI shielding effectiveness (51.5 dB). Remarkably, the EMIST still maintains its superhydrophobic feature and high EMI shielding level (42.6 dB) even after 5000 stretching-releasing cycles. Moreover, the EMIST exhibits strong resistance to ultrasonic treatment up to 60 min, peeling test up to 100 cycles, strong acidic/alkaline solutions, and different organic solvents, indicating its outstanding mechanical robustness and chemical durability. These attractive features of the EMIST are mainly a result of the joint action of AgNWs, carbon nanotubes, polytetrafluoroethylene nanoparticles, and fluoroacrylic polymer. This work offers a promising approach for the design of future durable, superhydrophobic EMISTs, which are capable of remaining fully functional against long-time exposure to extreme conditions, for example, wet and corrosive environments. FAU - Jia, Li-Chuan AU - Jia LC FAU - Zhang, Guoqiang AU - Zhang G AUID- ORCID: 0000-0002-7734-0236 AD - Department of Macromolecular Science and Engineering , Case Western Reserve University , Cleveland , Ohio 44106-7202 , United States. FAU - Xu, Ling AU - Xu L FAU - Sun, Wen-Jin AU - Sun WJ FAU - Zhong, Gan-Ji AU - Zhong GJ AUID- ORCID: 0000-0002-8540-7293 FAU - Lei, Jun AU - Lei J AUID- ORCID: 0000-0001-6803-5216 FAU - Yan, Ding-Xiang AU - Yan DX AUID- ORCID: 0000-0002-9563-2910 FAU - Li, Zhong-Ming AU - Li ZM AUID- ORCID: 0000-0001-7203-1453 LA - eng PT - Journal Article DEP - 20181219 PL - United States TA - ACS Appl Mater Interfaces JT - ACS applied materials & interfaces JID - 101504991 OTO - NOTNLM OT - EMI shielding OT - chemical durability OT - conductive textile OT - mechanical robustness OT - superhydrophobic EDAT- 2018/12/07 06:00 MHDA- 2018/12/07 06:01 CRDT- 2018/12/07 06:00 PHST- 2018/12/07 06:00 [pubmed] PHST- 2018/12/07 06:01 [medline] PHST- 2018/12/07 06:00 [entrez] AID - 10.1021/acsami.8b18459 [doi] PST - ppublish SO - ACS Appl Mater Interfaces. 2019 Jan 9;11(1):1680-1688. doi: 10.1021/acsami.8b18459. Epub 2018 Dec 19. PMID- 21214351 OWN - NLM STAT- MEDLINE DCOM- 20110421 LR - 20211020 IS - 1938-162X (Electronic) IS - 1062-6050 (Print) IS - 1062-6050 (Linking) VI - 46 IP - 1 DP - 2011 Jan-Feb TI - Core temperature and sweat responses in professional women's tennis players during tournament play in the heat. PG - 55-60 LID - 10.4085/1062-6050-46.1.55 [doi] AB - CONTEXT: Tennis is often played in hot, humid environments, intensifying the thermoregulatory strain placed on the athletes. As a safety measure, some tennis organizations allow for a 10-minute break in play between the second and third sets when environmental conditions are extreme. However, the actual effect of these breaks in reducing core temperature is unknown. OBJECTIVE: To determine change in core temperature after a 10-minute break in play and assess fluid balance in professional female tennis players during tournament matches in the heat. DESIGN: Cross-sectional study. SETTING: A Women's Tennis Association Tour-sanctioned outdoor tournament on hard courts under hot conditions (30.3°C ± 2.3°C). PATIENTS OR OTHER PARTICIPANTS: Seven professional tennis players. MAIN OUTCOME MEASURE(S): Change in core temperature after a 10-minute break in tournament play, fluid intake, and sweat losses during match play. RESULTS: Core temperature was reduced from 38.92°C to 38.67°C (change of -0.25°C ± 0.20°C) when a break was taken (P  =  .02). Mean sweat rate during match play was 2.0 ± 0.5 L/h. During that time, mean fluid intake was 1.5 ± 0.5 L/h, resulting in a 1.2% ± 1.0% reduction in body mass. CONCLUSIONS: Female professional tennis players are subjected to high heat loads during match play in hot environments. However, a 10-minute break in play decreased core temperature in 6 of 7 players by an average of 0.25°C, indicating that the break provides practical benefits in the field. Furthermore, although mean sweat rate in this group of female tennis players was high, most athletes were still able to minimize mass loss to less than 2% of their prematch weight. FAU - Tippet, Melissa L AU - Tippet ML AD - Gatorade Sports Science Institute, Barrington, IL 60010, USA. Melissa.Tippet@pepsico.com FAU - Stofan, John R AU - Stofan JR FAU - Lacambra, Magie AU - Lacambra M FAU - Horswill, Craig A AU - Horswill CA LA - eng PT - Journal Article PL - United States TA - J Athl Train JT - Journal of athletic training JID - 9301647 SB - IM MH - Adolescent MH - Adult MH - *Athletes MH - *Body Temperature MH - *Body Temperature Regulation MH - Dehydration MH - Female MH - *Hot Temperature MH - Humans MH - Physical Exertion MH - Rest MH - *Sweating MH - *Tennis MH - Water-Electrolyte Balance MH - Young Adult PMC - PMC3017490 EDAT- 2011/01/11 06:00 MHDA- 2011/04/22 06:00 PMCR- 2012/01/01 CRDT- 2011/01/11 06:00 PHST- 2011/01/11 06:00 [entrez] PHST- 2011/01/11 06:00 [pubmed] PHST- 2011/04/22 06:00 [medline] PHST- 2012/01/01 00:00 [pmc-release] AID - 10.4085/1062-6050-46.1.55 [doi] PST - ppublish SO - J Athl Train. 2011 Jan-Feb;46(1):55-60. doi: 10.4085/1062-6050-46.1.55. PMID- 35199198 OWN - NLM STAT- MEDLINE DCOM- 20220517 LR - 20220517 IS - 1432-1041 (Electronic) IS - 0031-6970 (Linking) VI - 78 IP - 6 DP - 2022 Jun TI - Desmopressin therapy in children and adults: pharmacological considerations and clinical implications. PG - 907-917 LID - 10.1007/s00228-022-03297-z [doi] AB - PURPOSE: This review aims to provide prescribing clinicians a deeper appreciation of desmopressin's clinical indications and formulation types, to better balance efficacy and safety through proper formulation selection. BACKGROUND: Since its discovery 50 years ago, desmopressin's antidiuretic properties have been used for central diabetes insipidus, primary monosymptomatic nocturnal enuresis and adult nocturnal polyuria, while its coagulant effects are useful for mild hemophilia A and von Willebrand Disease. During this time, newer formulations of desmopressin have also been introduced to the market raising questions on interchangeability, dose conversion and safety. The wide array of clinical indications and variable pharmacokinetic properties of different desmopressin preparations raises the possibility of medication error, especially the risk of hyponatraemia. METHODOLOGY: A narrative review to explore clinically relevant aspects of desmopressin therapy, synthesising information obtained from searches of published literature. RESULTS: We identified that the risk factors for developing hyponatremia include extremes of age, existing comorbidity, drug interaction, intranasal formulations and intercurrent illness. We describe the dose equivalence between all formulations to facilitate conversion. We highlight that in view of inter-subject variability, close monitoring is recommended when switching preparations. We found that paediatric data remains limited, leading to recent proposals for age- and weight-based dosing regimens. CONCLUSION: The risk of hyponatremia, albeit small, can be reduced by adhering to the indication-specific doses and taking steps to govern the safe prescription of the drug. Further paediatric clinical trials are awaited to expand the evidence base of childhood desmopressin therapy. CI - © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Chin, Xinyi AU - Chin X AUID- ORCID: 0000-0002-6010-0930 AD - Department of Paediatrics, Endocrinology Service, KK Women's and Children's Hospital, Singapore, Singapore. chin.xinyi@singhealth.com.sg. FAU - Teo, Shao Wei AU - Teo SW AD - Pharmacy Department, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Lim, Soo Ting AU - Lim ST AD - Nursing Specialist Service, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ng, Yong Hong AU - Ng YH AUID- ORCID: 0000-0001-8884-1805 AD - Department of Paediatrics, Nephrology Service, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Han, How Chuan AU - Han HC AD - Department of Urogynaecology, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AUID- ORCID: 0000-0003-1083-7958 AD - Department of Paediatrics, Endocrinology Service, KK Women's and Children's Hospital, Singapore, Singapore. LA - eng PT - Journal Article PT - Review DEP - 20220223 PL - Germany TA - Eur J Clin Pharmacol JT - European journal of clinical pharmacology JID - 1256165 RN - 0 (Antidiuretic Agents) RN - ENR1LLB0FP (Deamino Arginine Vasopressin) SB - IM MH - Administration, Intranasal MH - Administration, Oral MH - Adult MH - *Antidiuretic Agents/adverse effects MH - Child MH - Deamino Arginine Vasopressin/adverse effects MH - Humans MH - *Hyponatremia/chemically induced/drug therapy OTO - NOTNLM OT - Children OT - DDAVP OT - Desmopressin OT - Intranasal OT - MELT OT - Oral lyophilisates OT - PD OT - PK OT - Paediatric OT - Pharmacodynamics OT - Pharmacokinetics EDAT- 2022/02/25 06:00 MHDA- 2022/05/18 06:00 CRDT- 2022/02/24 05:46 PHST- 2021/12/08 00:00 [received] PHST- 2022/02/15 00:00 [accepted] PHST- 2022/02/25 06:00 [pubmed] PHST- 2022/05/18 06:00 [medline] PHST- 2022/02/24 05:46 [entrez] AID - 10.1007/s00228-022-03297-z [pii] AID - 10.1007/s00228-022-03297-z [doi] PST - ppublish SO - Eur J Clin Pharmacol. 2022 Jun;78(6):907-917. doi: 10.1007/s00228-022-03297-z. Epub 2022 Feb 23. PMID- 35811205 OWN - NLM STAT- MEDLINE DCOM- 20220816 LR - 20220921 IS - 1873-2518 (Electronic) IS - 0264-410X (Linking) VI - 40 IP - 33 DP - 2022 Aug 5 TI - Pneumococcal and influenza vaccination coverage among at-risk adults: A 5-year French national observational study. PG - 4911-4921 LID - S0264-410X(22)00841-6 [pii] LID - 10.1016/j.vaccine.2022.06.071 [doi] AB - INTRODUCTION: The risk of developing pneumococcal infections increases with certain chronic conditions and in immunocompromised patients. We aimed to monitor pneumococcal vaccination coverage in at-risk patients and to examine factors associated with pneumococcal vaccination in France. MATERIAL AND METHODS: In this annual cross-sectional study, at-risk patients were extracted between 2014 and 2018 from the National Health Insurance's (NHI) General scheme's claims database with their vaccine reimbursements. Descriptive analyses and a logistic model were performed to assess the influence of healthcare use and medical and demographic factors on pneumococcal vaccination. RESULTS AND DISCUSSION: In 2018, 4.5% of 4,045,021 at-risk adults were up to date with their pneumococcal vaccination. During the study period, the number of patients with chronic medical conditions (86% of 4,045,021) increased by 10.1%, but vaccination coverage decreased from 12.9% to 2.9%. The population with immunocompromised status (14% of 4,045,021) increased by 16.2% and vaccination coverage from 10.3% to 18.8%. Influenza vaccination coverage was much higher and stable (around 45.0%). Factors associated with pneumococcal vaccination were: immunocompromised status vs. having a chronic medical condition (odds ratio [OR] 4.72), influenza vaccination (OR 2.36-3.42), hepatitis B vaccination (OR 2.82), DTPolio vaccination (OR 1.52), ≥5 specialist physicians' visits (OR 1.17), and age above 74 (OR 1.12). Pneumococcal vaccine dispensing was extremely low (median of 9per GP,1per specialist over 9 years) despite frequent healthcare visits. CONCLUSION: Pneumococcal and influenza vaccination coverage of adults at risk of pneumococcal disease fell well below public health expectations. Invitations for pneumococcal vaccination should be sent by the NHI to high-risk patients. Patient management protocols should include pneumococcal vaccination. Patients with multiple comorbidities are a high-priority population given the large potential health gains offered by pneumococcal vaccination. Commitment of both scientific societies and health authorities is urgently needed to increase vaccination coverage in at-risk populations. CI - Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Wyplosz, Benjamin AU - Wyplosz B AD - AP-HP, Bicêtre University Hospital, Service de maladies infectieuses et tropicales, Centre de vaccinations internationales et de l'immunodéprimé, Le Kremlin-Bicêtre, France. Electronic address: benjamin.wyplosz@aphp.fr. FAU - Fernandes, Jérôme AU - Fernandes J AD - Medical Information Department, Bayonne Hospital, Bayonne, France. Electronic address: jerome.fernandes@lilo.org. FAU - Sultan, Ariane AU - Sultan A AD - PhyMedExp, University Montpellier, CNRS, INSERM, Endocrinology-Diabetology-Nutrition Department, University Montpellier, 34295 Montpellier, France. Electronic address: a-sultan@chu-montpellier.fr. FAU - Roche, Nicolas AU - Roche N AD - Pneumology, AP-HP, Cochin Hospital, Paris, France. Electronic address: nicolas.roche@aphp.fr. FAU - Roubille, François AU - Roubille F AD - Cardiology, Montpellier University Hospital, Montpellier, France. Electronic address: francois.roubille@gmail.com. FAU - Loubet, Paul AU - Loubet P AD - Service des Maladies infectieuses et Tropicales, CHU de Nîmes - INSERM U1047 - Université de Montpellier, Nîmes (France). Electronic address: paul.loubet@chu-nimes.fr. FAU - Fougère, Bertrand AU - Fougère B AD - Division of Geriatric Medicine, Tours University Hospital, Tours, France. Electronic address: bertrand.fougere@univ-tours.fr. FAU - Moulin, Bruno AU - Moulin B AD - Nephrology and Transplantation, Strasbourg University Hospital, Strasbourg, France. Electronic address: bmoulin@me.com. FAU - Duhot, Didier AU - Duhot D AD - Société Française de Médecine Générale, Issy les Moulineaux, France. Electronic address: d.duhot@sfmg.org. FAU - Vainchtock, Alexandre AU - Vainchtock A AD - HEVA, Lyon, France. Electronic address: avainchtock@hevaweb.com. FAU - Raguideau, Fanny AU - Raguideau F AD - HEVA, Lyon, France. Electronic address: fraguideau@hevaweb.com. FAU - Lortet-Tieulent, Joannie AU - Lortet-Tieulent J AD - HEVA, Lyon, France. Electronic address: jtieulent@hevaweb.com. FAU - Blanc, Emmanuelle AU - Blanc E AD - Pfizer Vaccines, Paris, France. Electronic address: emmanuelle.blanc@pfizer.com. FAU - Moïsi, Jennifer AU - Moïsi J AD - Pfizer Vaccines, Paris, France. Electronic address: jennifer.moisi@pfizer.com. FAU - Goussiaume, Gwenaël AU - Goussiaume G AD - Pfizer Vaccines, Paris, France. Electronic address: gwenael.goussiaume@pfizer.com. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20220707 PL - Netherlands TA - Vaccine JT - Vaccine JID - 8406899 RN - 0 (Influenza Vaccines) RN - 0 (Pneumococcal Vaccines) SB - IM MH - Adult MH - Cross-Sectional Studies MH - Humans MH - *Influenza Vaccines MH - *Influenza, Human/epidemiology/prevention & control MH - *Pneumococcal Infections/epidemiology/prevention & control MH - Pneumococcal Vaccines MH - Streptococcus pneumoniae MH - Vaccination MH - Vaccination Coverage OTO - NOTNLM OT - Immunocompromised OT - Influenza OT - Pneumococcal infection OT - SNDS OT - Vaccine COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Benjamin Wyplosz reports consulting fees from Pfizer; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Pfizer, GSK, and Sanofi-Pasteur; Support for attending meetings and/or travel from Pfizer. Jérôme Fernandes reports support for the present manuscript (e.g., funding, provision of study materials, medical writing, article processing charges, etc.) from HEVA (personal fees); consulting fees from Astellas Pharma and Takeda. Ariane Sultan reports consulting fees (honoraria) from Pfizer, MSD, Lilly, Novo, Amgen, Sanofi, Servier, Urgo, Astra-Zeneca; honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Pfizer, MSD, Lilly, Novo, Amgen, Sanofi, Servier, Urgo, Astra-Zeneca; Support for attending meetings and/or travel from Lilly, Novo, Sanofi, MSD; Participation on a Data Safety Monitoring Board or Advisory Board (honoraria) from Pfizer, MSD, Lilly, Novo, GSK, Sanofi, Amgen. Nicolas Roche reports grants or contracts (to his research institute) from GSK, Boehringer Ingelheim, Pfizer, Novartis; consulting fees from Boehringer Ingelheim, Novartis, Pfizer, Teva, GSK, AstraZeneca, Chiesi, Sanofi, Zambon; Payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events from Boehringer Ingelheim, Novartis, Pfizer, Teva, GSK, AstraZeneca, Chiesi, Sanofi, Zambon. EDAT- 2022/07/11 06:00 MHDA- 2022/08/17 06:00 CRDT- 2022/07/10 22:05 PHST- 2022/02/14 00:00 [received] PHST- 2022/06/24 00:00 [revised] PHST- 2022/06/26 00:00 [accepted] PHST- 2022/07/11 06:00 [pubmed] PHST- 2022/08/17 06:00 [medline] PHST- 2022/07/10 22:05 [entrez] AID - S0264-410X(22)00841-6 [pii] AID - 10.1016/j.vaccine.2022.06.071 [doi] PST - ppublish SO - Vaccine. 2022 Aug 5;40(33):4911-4921. doi: 10.1016/j.vaccine.2022.06.071. Epub 2022 Jul 7. PMID- 21389853 OWN - NLM STAT- MEDLINE DCOM- 20111013 LR - 20220309 IS - 1536-4798 (Electronic) IS - 0277-3740 (Linking) VI - 30 IP - 8 DP - 2011 Aug TI - Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea. PG - 917-9 LID - 10.1097/ICO.0b013e31820143d1 [doi] AB - PURPOSE: We report a case of failure of corneal collagen cross-linking (CXL) for progressive keratoconus after preoperative stromal swelling with hypoosmolar riboflavin solution in an extremely thin cornea. METHODS: CXL was performed using the protocol established for the treatment of thin corneas. Preoperative minimal thickness after abrasion was 268 μm and increased to 406 μm after swelling with hypoosmolar riboflavin solution. RESULTS: Despite CXL, a distinct progression of up to 1.9 diopters was observed at 3 months after the procedure on the anterior corneal surface. At 6 months after CXL, progression had increased to 2.3 diopters. Although swelling with hypoosmolar riboflavin solution was effective and led to a preoperative thickness of more than 400 μm, the increase in biomechanical resistance was not sufficient to arrest the progression of the disease. CONCLUSIONS: Little is known about the minimal stromal thickness required for effective CXL to occur. Although swelling with hypoosmolar riboflavin solution over 400 μm and safety of the procedure can be achieved in even thinner corneas, the outcome of this case suggests that a minimal preoperative stromal thickness of 330 μm needs to be respected for a successful CXL procedure. FAU - Hafezi, Farhad AU - Hafezi F AD - Geneva University Hospitals, Geneva, Switzerland. farhad@hafezi.ch LA - eng PT - Case Reports PT - Journal Article PL - United States TA - Cornea JT - Cornea JID - 8216186 RN - 0 (Cross-Linking Reagents) RN - 0 (Hypotonic Solutions) RN - 0 (Photosensitizing Agents) RN - 9007-34-5 (Collagen) RN - TLM2976OFR (Riboflavin) SB - IM MH - Collagen/*metabolism MH - Corneal Stroma/metabolism/*pathology MH - Corneal Topography MH - *Cross-Linking Reagents MH - Disease Progression MH - Humans MH - Hypotonic Solutions/*therapeutic use MH - Keratoconus/*drug therapy/metabolism MH - Male MH - Middle Aged MH - Osmolar Concentration MH - Photosensitizing Agents/*therapeutic use MH - Riboflavin/*therapeutic use MH - Treatment Failure MH - Ultraviolet Rays MH - Visual Acuity/physiology EDAT- 2011/03/11 06:00 MHDA- 2011/10/14 06:00 CRDT- 2011/03/11 06:00 PHST- 2011/03/11 06:00 [entrez] PHST- 2011/03/11 06:00 [pubmed] PHST- 2011/10/14 06:00 [medline] AID - 10.1097/ICO.0b013e31820143d1 [doi] PST - ppublish SO - Cornea. 2011 Aug;30(8):917-9. doi: 10.1097/ICO.0b013e31820143d1. PMID- 33317356 OWN - NLM STAT- MEDLINE DCOM- 20210901 LR - 20210901 IS - 1747-4094 (Electronic) IS - 1747-4094 (Linking) VI - 14 IP - 1 DP - 2021 Jan TI - An evaluation of ferric derisomaltose as a treatment for anemia. PG - 7-29 LID - 10.1080/17474086.2021.1858406 [doi] AB - Introduction: Originally approved in Europe in 2009, ferric derisomaltose is the most recently authorized intravenous iron compound in the United States of America (2020). Ferric derisomaltose given as a rapid high-dose infusion can allow complete iron repletion in a single dose and it is now widely used in the treatment of iron deficiency. Areas covered: The chemistry, pharmacodynamics and pharmacokinetics of ferric derisomaltose are reviewed. Results from phase II, III and IV trials regarding efficacy and safety are presented. Mechanisms behind minor infusion reactions, hypersensitivity and hypophosphatemia are discussed. The economic impact of ferric derisomaltose use is presented. Data pertaining to the use of ferric derisomaltose in iron deficiency anemia, chronic kidney disease, inflammatory bowel disease, chronic heart failure, perioperative care and other patient groups are comprehensively covered. Expert opinion: Ferric derisomaltose is an effective intravenous iron formulation with a good safety profile, providing rapid, cost-effective iron repletion. Ferric derisomaltose releases low quantities of labile iron relative to older compounds. Anaphylaxis is extremely rare, and 'Fishbane' reactions are uncommon. Hypophosphatemia following ferric derisomaltose administration is infrequent in comparison to other intravenous irons such as ferric carboxymaltose. The scope of ferric derisomaltose use is growing with increasing research in these areas. FAU - Kassianides, Xenophon AU - Kassianides X AD - Academic Renal Department, Hull University Teaching Hospitals NHS Trust and Hull York Medical School , Hull, UK. FAU - Bodington, Richard AU - Bodington R AD - Academic Renal Department, Hull University Teaching Hospitals NHS Trust and Hull York Medical School , Hull, UK. FAU - Bhandari, Sunil AU - Bhandari S AUID- ORCID: 0000-0002-0996-9622 AD - Academic Renal Department, Hull University Teaching Hospitals NHS Trust and Hull York Medical School , Hull, UK. LA - eng PT - Journal Article PT - Review DEP - 20201214 PL - England TA - Expert Rev Hematol JT - Expert review of hematology JID - 101485942 RN - 0 (Disaccharides) RN - 0 (Ferric Compounds) RN - AHU547PI9H (ferric derisomaltose) SB - IM MH - Anemia/*drug therapy MH - Animals MH - Clinical Trials as Topic MH - Disaccharides/adverse effects/pharmacokinetics/pharmacology/*therapeutic use MH - Drug and Narcotic Control MH - Ferric Compounds/adverse effects/pharmacokinetics/pharmacology/therapeutic use MH - Humans MH - Treatment Outcome OTO - NOTNLM OT - Anemia OT - chronic kidney disease OT - efficacy OT - ferric derisomaltose OT - hypersensitivity OT - hypophosphatemia OT - inflammatory bowel disease OT - intravenous iron OT - safety EDAT- 2020/12/16 06:00 MHDA- 2021/09/02 06:00 CRDT- 2020/12/15 05:38 PHST- 2020/12/16 06:00 [pubmed] PHST- 2021/09/02 06:00 [medline] PHST- 2020/12/15 05:38 [entrez] AID - 10.1080/17474086.2021.1858406 [doi] PST - ppublish SO - Expert Rev Hematol. 2021 Jan;14(1):7-29. doi: 10.1080/17474086.2021.1858406. Epub 2020 Dec 14. PMID- 29330184 OWN - NLM STAT- MEDLINE DCOM- 20190802 LR - 20190802 IS - 1098-5336 (Electronic) IS - 0099-2240 (Print) IS - 0099-2240 (Linking) VI - 84 IP - 5 DP - 2018 Mar 1 TI - Microbial Diversity and Putative Opportunistic Pathogens in Dishwasher Biofilm Communities. LID - 10.1128/AEM.02755-17 [doi] LID - e02755-17 AB - Extreme habitats are not only limited to natural environments, but also exist in manmade systems, for instance, household appliances such as dishwashers. Limiting factors, such as high temperatures, high and low pHs, high NaCl concentrations, presence of detergents, and shear force from water during washing cycles, define microbial survival in this extreme system. Fungal and bacterial diversity in biofilms isolated from rubber seals of 24 different household dishwashers was investigated using next-generation sequencing. Bacterial genera such as Pseudomonas, Escherichia, and Acinetobacter, known to include opportunistic pathogens, were represented in most samples. The most frequently encountered fungal genera in these samples belonged to Candida, Cryptococcus, and Rhodotorula, also known to include opportunistic pathogenic representatives. This study showed how specific conditions of the dishwashers impact the abundance of microbial groups and investigated the interkingdom and intrakingdom interactions that shape these biofilms. The age, usage frequency, and hardness of incoming tap water of dishwashers had significant impact on bacterial and fungal community compositions. Representatives of Candida spp. were found at the highest prevalence (100%) in all dishwashers and are assumed to be one of the first colonizers in recently purchased dishwashers. Pairwise correlations in tested microbiomes showed that certain bacterial groups cooccur, as did the fungal groups. In mixed bacterial-fungal biofilms, early adhesion, contact, and interactions were vital in the process of biofilm formation, where mixed complexes of bacteria and fungi could provide a preliminary biogenic structure for the establishment of these biofilms.IMPORTANCE Worldwide demand for household appliances, such as dishwashers and washing machines, is increasing, as is the number of immunocompromised individuals. The harsh conditions in household dishwashers should prevent the growth of most microorganisms. However, our research shows that persisting polyextremotolerant groups of microorganisms in household appliances are well established under these unfavorable conditions and supported by the biofilm mode of growth. The significance of our research is in identifying the microbial composition of biofilms formed on dishwasher rubber seals, how diverse abiotic conditions affect microbiota, and which key microbial members were represented in early colonization and contamination of dishwashers, as these appliances can present a source of domestic cross-contamination that leads to broader medical impacts. CI - Copyright © 2018 Raghupathi et al. FAU - Raghupathi, Prem Krishnan AU - Raghupathi PK AD - Molecular Microbial Ecology Group, Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. AD - Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. FAU - Zupančič, Jerneja AU - Zupančič J AD - Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia. FAU - Brejnrod, Asker Daniel AU - Brejnrod AD AD - Molecular Microbial Ecology Group, Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. FAU - Jacquiod, Samuel AU - Jacquiod S AD - Molecular Microbial Ecology Group, Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. FAU - Houf, Kurt AU - Houf K AUID- ORCID: 0000-0002-0909-7756 AD - Department of Veterinary Public Health and Food Safety, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. FAU - Burmølle, Mette AU - Burmølle M AD - Molecular Microbial Ecology Group, Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark. FAU - Gunde-Cimerman, Nina AU - Gunde-Cimerman N AD - Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia nina.gunde-cimerman@bf.uni-lj.si sjs@bio.ku.dk. FAU - Sørensen, Søren J AU - Sørensen SJ AUID- ORCID: 0000-0001-6227-9906 AD - Molecular Microbial Ecology Group, Section of Microbiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark nina.gunde-cimerman@bf.uni-lj.si sjs@bio.ku.dk. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180214 PL - United States TA - Appl Environ Microbiol JT - Applied and environmental microbiology JID - 7605801 MH - Bacteria/growth & development/isolation & purification MH - *Bacterial Physiological Phenomena MH - Biofilms/*growth & development MH - Fungi/growth & development/isolation & purification/*physiology MH - *Household Articles MH - Microbiota/*physiology PMC - PMC5812945 OTO - NOTNLM OT - abiotic conditions OT - biofilms OT - dishwasher OT - fungal-bacterial interactions OT - opportunistic fungi OT - putative pathogens EDAT- 2018/01/14 06:00 MHDA- 2019/08/03 06:00 PMCR- 2018/02/14 CRDT- 2018/01/14 06:00 PHST- 2017/12/12 00:00 [received] PHST- 2017/12/12 00:00 [accepted] PHST- 2018/01/14 06:00 [pubmed] PHST- 2019/08/03 06:00 [medline] PHST- 2018/01/14 06:00 [entrez] PHST- 2018/02/14 00:00 [pmc-release] AID - AEM.02755-17 [pii] AID - 02755-17 [pii] AID - 10.1128/AEM.02755-17 [doi] PST - epublish SO - Appl Environ Microbiol. 2018 Feb 14;84(5):e02755-17. doi: 10.1128/AEM.02755-17. Print 2018 Mar 1. PMID- 30689365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20200407 LR - 20200408 IS - 1520-6890 (Electronic) IS - 0009-2665 (Linking) VI - 119 IP - 3 DP - 2019 Feb 13 TI - Polytetrafluoroethylene: Synthesis and Characterization of the Original Extreme Polymer. PG - 1763-1805 LID - 10.1021/acs.chemrev.8b00458 [doi] AB - This Review aims to be a comprehensive, authoritative, and critical review of general interest to the chemistry community (both academia and industry) as it contains an extensive overview of all published data on the homopolymerization of tetrafluoroethylene (TFE), detailing the TFE homopolymerization process and the resulting chemical and physical properties. Several reviews and encyclopedia chapters on the properties and applications of fluoropolymers in general have been published, including various reviews that extensively report copolymers of TFE (listed below). Despite this, a thorough review of the specific methods of synthesis of the homopolymer, and the relationships between synthesis conditions and the physicochemical properties of the material prepared, has not been available. This Review intends to fill that gap. As known, PTFE and its marginally modified derivatives comprise some 60-65% of the total international fluoropolymer market with a global increase of ca. 7% per annum of its production. Numerous companies, such as Asahi Glass, Solvay Specialty Polymers, Daikin, DuPont/Chemours, Juhua, 3F, 3M/Dyneon, etc., produce TFE homopolymers. Such polymers, both high-molecular-mass materials and waxes, are chemically inert and hydrophobic and exhibit an excellent thermal stability as well as an exceptionally low coefficient of friction. These polymers find use in applications ranging from coatings and lubrication to pyrotechnics, and an extensive industry (electronic, aerospace, wires and cables, and textiles) has been built around them. South Africa, being the third largest producer of fluorspar (CaF(2)), the precursor to hydrogen fluoride and fluorine, has embarked on an industrial initiative to locally beneficiate its fluorspar reserves, with the local production of fluoropolymers being one projected outcome. As our manuscript focuses specifically on the homopolymerization of TFE (the starting point for all fluoropolymer industries), it will be of considerable use to start-up companies and other commercial entities looking to enter the fluoropolymer market, as well as to end-user companies. The manuscript commences with a short discussion on the synthesis and production of TFE (both at industrial and laboratory scales), including the safety aspects surrounding handling (because that monomer is regarded as explosive if brought into contact with oxygen due to the formation of peroxides), transport, and storage, and then expands into detailed discussions dealing with aspects such as the various additives used (buffers, chain transfer agents, surfactants, etc.), the solvent environment, and the reaction conditions. A further section reports the properties of PTFE with respect to the polymerization conditions as well as an overview on the specialized techniques used to characterize PTFE. Finally, the applications of PTFE in various fields, ranging from electrical insulation to tribological to medical applications, as well as chemically resistant coatings and pyrotechnics, are discussed. FAU - Puts, Gerard J AU - Puts GJ AD - Department of Chemical Engineering , University of Pretoria , Pretoria 0002 , South Africa. FAU - Crouse, Philip AU - Crouse P AD - Department of Chemical Engineering , University of Pretoria , Pretoria 0002 , South Africa. FAU - Ameduri, Bruno M AU - Ameduri BM AUID- ORCID: 0000-0003-4217-6664 AD - Ingenierie et Architectures Macromoléculaires , Institut Charles Gerhardt , UMR 5253 CNRS, UM, ENSCM, Place Eugène Bataillon , 34095 Montpellier , Cedex 5 , France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190128 PL - United States TA - Chem Rev JT - Chemical reviews JID - 2985134R SB - IM EDAT- 2019/01/29 06:00 MHDA- 2019/01/29 06:01 CRDT- 2019/01/29 06:00 PHST- 2019/01/29 06:00 [pubmed] PHST- 2019/01/29 06:01 [medline] PHST- 2019/01/29 06:00 [entrez] AID - 10.1021/acs.chemrev.8b00458 [doi] PST - ppublish SO - Chem Rev. 2019 Feb 13;119(3):1763-1805. doi: 10.1021/acs.chemrev.8b00458. Epub 2019 Jan 28. PMID- 36116255 OWN - NLM STAT- MEDLINE DCOM- 20221019 LR - 20221019 IS - 1095-8630 (Electronic) IS - 0301-4797 (Linking) VI - 323 DP - 2022 Dec 1 TI - Rhodococcus: A promising genus of actinomycetes for the bioremediation of organic and inorganic contaminants. PG - 116220 LID - S0301-4797(22)01793-5 [pii] LID - 10.1016/j.jenvman.2022.116220 [doi] AB - Rhodococcus is a genus of actinomycetes that has been explored by the scientific community for different purposes, especially for bioremediation uses. However, the mechanisms governing Rhodococcus-mediated bioremediation processes are far from being fully elucidated. In this sense, this work aimed to compile the recent advances in the use of Rhodococcus for the bioremediation of organic and inorganic contaminants present in different environmental compartments. We reviewed the bioremediation capacity and mechanisms of Rhodococcus spp. in the treatment of polycyclic aromatic hydrocarbons, phenolic substances, emerging contaminants, heavy metals, and dyes given their human health risks and environmental concern. Different bioremediation techniques were discussed, including experimental conditions, treatment efficiencies, mechanisms, and degradation pathways. The use of Rhodococcus strains in the bioremediation of several compounds is a promising approach due to their features, primarily the presence of appropriate enzyme systems, which result in high decontamination efficiencies; but that vary according to experimental conditions. Besides, the genus Rhodococcus contains a small number of opportunistic species and pathogens, representing an advantage from the point of view of safety. Advances in analytical detection techniques and Molecular Biology have been collaborating to improve the understanding of the mechanisms and pathways involved in bioremediation processes. In the context of using Rhodococcus spp. as bioremediation agents, there is a need for more studies that 1) evaluate the role of these actinomycetes on a pilot and field scale; 2) use genetic engineering tools and consortia with other microorganisms to improve the bioremediation efficiency; and 3) isolate new Rhodococcus strains from environments with extreme and/or contaminated conditions aiming to explore their adaptive capabilities for bioremediation purposes. CI - Copyright © 2022 Elsevier Ltd. All rights reserved. FAU - Nazari, Mateus Torres AU - Nazari MT AD - Graduate Program in Civil and Environmental Engineering, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. FAU - Simon, Viviane AU - Simon V AD - Graduate Program in Civil and Environmental Engineering, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. FAU - Machado, Bruna Strieder AU - Machado BS AD - Faculty of Engineering and Architecture, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. FAU - Crestani, Larissa AU - Crestani L AD - Graduate Program in Chemical Engineering (PPGEQ), Federal University of Santa Maria (UFSM), Santa Maria, RS, Brazil. FAU - Marchezi, Giovana AU - Marchezi G AD - Faculty of Engineering and Architecture, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. FAU - Concolato, Gustavo AU - Concolato G AD - Faculty of Engineering and Architecture, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. FAU - Ferrari, Valdecir AU - Ferrari V AD - Graduate Program in Mining, Metallurgical and Materials Engineering (PPGE3M), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. FAU - Colla, Luciane Maria AU - Colla LM AD - Graduate Program in Civil and Environmental Engineering, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. Electronic address: lmcolla@upf.br. FAU - Piccin, Jeferson Steffanello AU - Piccin JS AD - Graduate Program in Civil and Environmental Engineering, University of Passo Fundo (UPF), Passo Fundo, RS, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20220915 PL - England TA - J Environ Manage JT - Journal of environmental management JID - 0401664 RN - 0 (Coloring Agents) RN - 0 (Metals, Heavy) RN - 0 (Polycyclic Aromatic Hydrocarbons) SB - IM MH - *Actinobacteria/metabolism MH - Actinomyces/metabolism MH - Biodegradation, Environmental MH - Coloring Agents/metabolism MH - Humans MH - *Metals, Heavy/metabolism MH - *Polycyclic Aromatic Hydrocarbons/metabolism MH - *Rhodococcus/genetics/metabolism OTO - NOTNLM OT - Dyes OT - Emerging contaminants OT - Heavy metals OT - Phenolic substances OT - Polycyclic aromatic hydrocarbons OT - Rhodococcus COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/09/19 06:00 MHDA- 2022/10/20 06:00 CRDT- 2022/09/18 18:13 PHST- 2022/06/15 00:00 [received] PHST- 2022/08/16 00:00 [revised] PHST- 2022/09/06 00:00 [accepted] PHST- 2022/09/19 06:00 [pubmed] PHST- 2022/10/20 06:00 [medline] PHST- 2022/09/18 18:13 [entrez] AID - S0301-4797(22)01793-5 [pii] AID - 10.1016/j.jenvman.2022.116220 [doi] PST - ppublish SO - J Environ Manage. 2022 Dec 1;323:116220. doi: 10.1016/j.jenvman.2022.116220. Epub 2022 Sep 15. PMID- 7488536 OWN - NLM STAT- MEDLINE DCOM- 19960104 LR - 20191031 IS - 0278-145X (Print) IS - 0278-145X (Linking) VI - 14 IP - 3 DP - 1995 Sep TI - Risk of acquiring AIDS from salivary exchange through cardiopulmonary resuscitation courses and mouth-to-mouth resuscitation. PG - 205-11 AB - In summary, the risk of transmission of HIV and other infectious diseases by saliva during CPR training practice is extremely low because of low infectious virus titers and properties of saliva that inhibit HIV. However, it is necessary to perform decontaminations of mannequins, by application of a suitable disinfectant and by a mechanical wipe-down with a sponge, to cleanse the external buccal area of the mannequin after contact with each CPR trainee. For health care and public safety professionals training and performance of MTM ventilation during CPR should be carried out with barrier devices such as the bag-valve-mask or face shield. Guidelines and standards of the AHA, American Red Cross, and the CDC for prevention of infection during CPR and emergency cardiac care are more fully available elsewhere. If the recommended procedures are followed, the risk of acquiring HIV from saliva during MTM should be extremely low. FAU - Sun, D AU - Sun D AD - Department of Oral Pathology, Dental School, University of Maryland at Baltimore, USA. FAU - Bennett, R B AU - Bennett RB FAU - Archibald, D W AU - Archibald DW LA - eng GR - DE10594/DE/NIDCR NIH HHS/United States GR - NS26665/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - United States TA - Semin Dermatol JT - Seminars in dermatology JID - 8211646 SB - IM MH - Acquired Immunodeficiency Syndrome/*etiology/transmission MH - Cardiopulmonary Resuscitation/*adverse effects MH - HIV/isolation & purification MH - Humans MH - Infectious Disease Transmission, Patient-to-Professional/prevention & control MH - Risk MH - Saliva/*virology RF - 76 EDAT- 1995/09/01 00:00 MHDA- 1995/09/01 00:01 CRDT- 1995/09/01 00:00 PHST- 1995/09/01 00:00 [pubmed] PHST- 1995/09/01 00:01 [medline] PHST- 1995/09/01 00:00 [entrez] AID - 10.1016/s1085-5629(05)80020-3 [doi] PST - ppublish SO - Semin Dermatol. 1995 Sep;14(3):205-11. doi: 10.1016/s1085-5629(05)80020-3. PMID- 36916993 OWN - NLM STAT- MEDLINE DCOM- 20230330 LR - 20231010 IS - 1793-6462 (Electronic) IS - 0129-0657 (Print) IS - 0129-0657 (Linking) VI - 33 IP - 4 DP - 2023 Apr TI - Electrical Stimulation Induced Current Distribution in Peripheral Nerves Varies Significantly with the Extent of Nerve Damage: A Computational Study Utilizing Convolutional Neural Network and Realistic Nerve Models. PG - 2350022 LID - 10.1142/S0129065723500223 [doi] AB - Electrical stimulation of the peripheral nervous system is a promising therapeutic option for several conditions; however, its effects on tissue and the safety of the stimulation remain poorly understood. In order to devise stimulation protocols that enhance therapeutic efficacy without the risk of causing tissue damage, we constructed computational models of peripheral nerve and stimulation cuffs based on extremely high-resolution cross-sectional images of the nerves using the most recent advances in computing power and machine learning techniques. We developed nerve models using nonstimulated (healthy) and over-stimulated (damaged) rat sciatic nerves to explore how nerve damage affects the induced current density distribution. Using our in-house computational, quasi-static, platform, and the Admittance Method (AM), we estimated the induced current distribution within the nerves and compared it for healthy and damaged nerves. We also estimated the extent of localized cell damage in both healthy and damaged nerve samples. When the nerve is damaged, as demonstrated principally by the decreased nerve fiber packing, the current penetrates deeper into the over-stimulated nerve than in the healthy sample. As safety limits for electrical stimulation of peripheral nerves still refer to the Shannon criterion to distinguish between safe and unsafe stimulation, the capability this work demonstrated is an important step toward the development of safety criteria that are specific to peripheral nerve and make use of the latest advances in computational bioelectromagnetics and machine learning, such as Python-based AM and CNN-based nerve image segmentation. FAU - Du, Jinze AU - Du J AD - Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA. AD - Institute for Technology and Medical Systems (ITEMS), Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. FAU - Morales, Andres AU - Morales A AD - Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA. AD - Institute for Technology and Medical Systems (ITEMS), Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. FAU - Kosta, Pragya AU - Kosta P AD - Institute for Technology and Medical Systems (ITEMS), Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. FAU - Bouteiller, Jean-Marie C AU - Bouteiller JC AD - Institute for Technology and Medical Systems (ITEMS), Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. AD - Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. FAU - Martinez-Navarrete, Gema AU - Martinez-Navarrete G AD - Institute of Bioengineering, University Miguel Hernandez, Elche and CIBER-BBN, Spain. FAU - Warren, David J AU - Warren DJ AD - Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA. AD - Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT 84112, USA. FAU - Fernandez, Eduardo AU - Fernandez E AD - Institute of Bioengineering, University Miguel Hernandez, Elche and CIBER-BBN, Spain. FAU - Lazzi, Gianluca AU - Lazzi G AD - Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089, USA. AD - Institute for Technology and Medical Systems (ITEMS), Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. AD - Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA. AD - Department of Ophthalmology, University of Southern California, Los Angeles, CA 90089, USA. LA - eng GR - R01 EB029271/EB/NIBIB NIH HHS/United States PT - Journal Article DEP - 20230315 PL - Singapore TA - Int J Neural Syst JT - International journal of neural systems JID - 9100527 SB - IM MH - Rats MH - Animals MH - *Sciatic Nerve/physiology MH - Electric Stimulation/methods MH - *Neural Networks, Computer PMC - PMC10561898 MID - NIHMS1934853 OTO - NOTNLM OT - Computational model OT - electrical stimulation OT - peripheral nerve OT - tissue safety EDAT- 2023/03/15 06:00 MHDA- 2023/03/30 06:11 PMCR- 2023/10/09 CRDT- 2023/03/14 10:13 PHST- 2023/03/30 06:11 [medline] PHST- 2023/03/15 06:00 [pubmed] PHST- 2023/03/14 10:13 [entrez] PHST- 2023/10/09 00:00 [pmc-release] AID - 10.1142/S0129065723500223 [doi] PST - ppublish SO - Int J Neural Syst. 2023 Apr;33(4):2350022. doi: 10.1142/S0129065723500223. Epub 2023 Mar 15. PMID- 2023435 OWN - NLM STAT- MEDLINE DCOM- 19910531 LR - 20220317 IS - 0022-5223 (Print) IS - 0022-5223 (Linking) VI - 101 IP - 5 DP - 1991 May TI - The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. PG - 783-94 AB - Cardiopulmonary bypass management in neonates, infants, and children often requires the use of deep hypothermia at 18 degrees C with occasional periods of circulatory arrest and represents marked physiologic extremes of temperature and perfusion. The safety of these techniques is largely dependent on the reduction of metabolism, particularly cerebral metabolism. We studied the effect of hypothermia on cerebral metabolism during cardiac surgery and quantified the changes. Cerebral metabolism was measured before, during, and after hypothermic cardiopulmonary bypass in 46 pediatric patients, aged 1 day to 14 years. Patients were grouped on the basis of the different bypass techniques commonly used in children: group A--moderate hypothermic bypass at 28 degrees C; group B--deep hypothermic bypass at 18 degrees to 20 degrees C with maintenance of continuous flow; and group C--deep hypothermic circulatory arrest at 18 degrees C. Cerebral metabolism significantly decreased under hypothermic conditions in all groups compared with control levels at normothermia, the data demonstrating an exponential relationship between temperature and cerebral metabolism and an average temperature coefficient of 3.65. There was no significant difference in the rate of metabolism reduction (temperature coefficient) in patients cooled to 28 degrees and 18 degrees C. From these data we were able to derive an equation that numerically expresses a hypothermic metabolic index, which quantitates duration of brain protection provided by reduction of cerebral metabolism owing to hypothermic bypass over any temperature range. Based on this index, patients cooled to 28 degrees C have a predicted ischemic tolerance of 11 to 19 minutes. The predicted duration that the brain can tolerate ischemia ("safe" period of deep hypothermic circulatory arrest) in patients cooled to 18 degrees C, based on our metabolic index, is 39 to 65 minutes, similar to the safe period of deep hypothermic circulatory arrest known to be tolerated clinically. In groups A and B (no circulatory arrest), cerebral metabolism returned to control in the rewarming phase of bypass and after bypass. In group C (circulatory arrest), cerebral metabolism and oxygen extraction remained significantly reduced during rewarming and after bypass, suggesting disordered cerebral metabolism and oxygen utilization after deep hypothermic circulatory arrest. The results of this study suggest that cerebral metabolism is exponentially related to temperature during hypothermic bypass with a temperature coefficient of 3.65 in neonates infants and children. Deep hypothermic circulatory arrest changes cerebral metabolism and blood flow after the arrest period despite adequate hypothermic suppression of metabolism. FAU - Greeley, W J AU - Greeley WJ AD - Department of Anesthesiology, Duke University Medical Center, Durham, N.C. 27710. FAU - Kern, F H AU - Kern FH FAU - Ungerleider, R M AU - Ungerleider RM FAU - Boyd, J L 3rd AU - Boyd JL 3rd FAU - Quill, T AU - Quill T FAU - Smith, L R AU - Smith LR FAU - Baldwin, B AU - Baldwin B FAU - Reves, J G AU - Reves JG LA - eng PT - Journal Article PL - United States TA - J Thorac Cardiovasc Surg JT - The Journal of thoracic and cardiovascular surgery JID - 0376343 SB - IM MH - Adolescent MH - Brain/*metabolism MH - *Cardiopulmonary Bypass MH - Cerebrovascular Circulation MH - Child MH - Child, Preschool MH - *Heart Arrest, Induced MH - Humans MH - *Hypothermia, Induced MH - Infant MH - Infant, Newborn MH - Oxygen Consumption EDAT- 1991/05/01 00:00 MHDA- 1991/05/01 00:01 CRDT- 1991/05/01 00:00 PHST- 1991/05/01 00:00 [pubmed] PHST- 1991/05/01 00:01 [medline] PHST- 1991/05/01 00:00 [entrez] PST - ppublish SO - J Thorac Cardiovasc Surg. 1991 May;101(5):783-94. PMID- 26535329 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20151104 LR - 20200930 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 2 IP - 5 DP - 2014 May TI - Single-Leg Balance Impairments Persist in Fully Operational Military Special Forces Operators With a Previous History of Low Back Pain. PG - 2325967114532780 LID - 10.1177/2325967114532780 [doi] LID - 2325967114532780 AB - BACKGROUND: Single-leg balance (SLB) can be chronically impaired after low back pain (LBP). Impaired SLB is a risk factor for recurrent LBP and lower extremity injury. In the United States military, the special forces operator (SFO) deploys on high-risk missions under extreme conditions, and impaired SLB can potentially threaten SFO safety and mission success. PURPOSE: To compare SLB in fully operational SFOs with and without a history of LBP. The hypothesis was that SLB deficits would be present in SFOs with a history of LBP. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: A total of 226 SFOs were included in this analysis. Comparisons were made between SFOs with and without medical chart documented history of LBP (LBP group [n = 43]: mean age = 31.2 ± 10.3 years, mean height = 177.3 ± 7.2 cm, mean mass = 87.3 ± 11.8 kg; healthy group [n = 183]: mean age = 28.0 ± 6.0 years, mean height = 177.9 ± 6.0 cm, mean mass = 84.9 ± 8.8 kg). Bilateral SLB was tested (eyes open and eyes closed) in both groups using a force plate. The variability in the ground-reaction forces was averaged across 3 trials for each leg for both conditions. Comparisons were made between legs in the LBP and between the LBP and healthy group (α = .05). RESULTS: There were significant between-group differences for each leg for both conditions, with the healthy group demonstrating better SLB compared with the LBP group. P values ranged from .01 to .03. CONCLUSION: Impaired SLB persists in SFOs with previously reported LBP. Balance assessments of individuals who report LBP may assist with designing targeted interventions to address potential deficits that may increase the risk of future injury. CLINICAL RELEVANCE: SFOs with a known history of LBP would benefit from examination of SLB and may benefit from balance training to resolve any deficits that may be present to lower the potential risk for future injury. FAU - Sell, Timothy C AU - Sell TC AD - Neuromuscular Research Laboratory, Department of Sports Medicine and Nutrition, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Clark, Nicholas C AU - Clark NC AD - Neuromuscular Research Laboratory, Department of Sports Medicine and Nutrition, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Wood, Dallas AU - Wood D AD - United States Navy, Norfolk, Virginia, USA. FAU - Abt, John P AU - Abt JP AD - Neuromuscular Research Laboratory, Department of Sports Medicine and Nutrition, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Lovalekar, Mita AU - Lovalekar M AD - Neuromuscular Research Laboratory, Department of Sports Medicine and Nutrition, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Lephart, Scott M AU - Lephart SM AD - Neuromuscular Research Laboratory, Department of Sports Medicine and Nutrition, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. LA - eng PT - Journal Article DEP - 20140512 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC4555543 OTO - NOTNLM OT - balance OT - low back pain OT - military OT - postural stability OT - special forces COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: This work was supported by the Office of Naval Research, Grant No. N00014071190/N000140810412. EDAT- 2014/05/01 00:00 MHDA- 2014/05/01 00:01 PMCR- 2014/05/01 CRDT- 2015/11/05 06:00 PHST- 2015/11/05 06:00 [entrez] PHST- 2014/05/01 00:00 [pubmed] PHST- 2014/05/01 00:01 [medline] PHST- 2014/05/01 00:00 [pmc-release] AID - 10.1177_2325967114532780 [pii] AID - 10.1177/2325967114532780 [doi] PST - epublish SO - Orthop J Sports Med. 2014 May 12;2(5):2325967114532780. doi: 10.1177/2325967114532780. eCollection 2014 May. PMID- 38740182 OWN - NLM STAT- MEDLINE DCOM- 20240621 LR - 20240621 IS - 1876-4754 (Electronic) IS - 1876-4754 (Linking) VI - 17 IP - 3 DP - 2024 May-Jun TI - Thresholds and mechanisms of human magnetophosphene perception induced by low f